WorldWideScience

Sample records for hybridization profile test

  1. Comparative Transcriptional Profiling of Three Super-Hybrid Rice Combinations

    Directory of Open Access Journals (Sweden)

    Yonggang Peng

    2014-03-01

    Full Text Available Utilization of heterosis has significantly increased rice yields. However, its mechanism remains unclear. In this study, comparative transcriptional profiles of three super-hybrid rice combinations, LY2163, LY2186 and LYP9, at the flowering and filling stages, were created using rice whole-genome oligonucleotide microarray. The LY2163, LY2186 and LYP9 hybrids yielded 1193, 1630 and 1046 differentially expressed genes (DGs, accounting for 3.2%, 4.4% and 2.8% of the total number of genes (36,926, respectively, after using the z-test (p < 0.01. Functional category analysis showed that the DGs in each hybrid combination were mainly classified into the carbohydrate metabolism and energy metabolism categories. Further analysis of the metabolic pathways showed that DGs were significantly enriched in the carbon fixation pathway (p < 0.01 for all three combinations. Over 80% of the DGs were located in rice quantitative trait loci (QTLs of the Gramene database, of which more than 90% were located in the yield related QTLs in all three combinations, which suggested that there was a correlation between DGs and rice heterosis. Pathway Studio analysis showed the presence of DGs in the circadian regulatory network of all three hybrid combinations, which suggested that the circadian clock had a role in rice heterosis. Our results provide information that can help to elucidate the molecular mechanism underlying rice heterosis.

  2. Comparative gene expression profiles between heterotic and non-heterotic hybrids of tetraploid Medicago sativa

    Directory of Open Access Journals (Sweden)

    Nettleton Dan

    2009-08-01

    Full Text Available Abstract Background Heterosis, the superior performance of hybrids relative to parents, has clear agricultural value, but its genetic control is unknown. Our objective was to test the hypotheses that hybrids expressing heterosis for biomass yield would show more gene expression levels that were different from midparental values and outside the range of parental values than hybrids that do not exhibit heterosis. Results We tested these hypotheses in three Medicago sativa (alfalfa genotypes and their three hybrids, two of which expressed heterosis for biomass yield and a third that did not, using Affymetrix M. truncatula GeneChip arrays. Alfalfa hybridized to approximately 47% of the M. truncatula probe sets. Probe set signal intensities were analyzed using MicroArray Suite v.5.0 (MAS and robust multi-array average (RMA algorithms. Based on MAS analysis, the two heterotic hybrids performed similarly, with about 27% of genes showing differential expression among the parents and their hybrid compared to 12.5% for the non-heterotic hybrid. At a false discovery rate of 0.15, 4.7% of differentially expressed genes in hybrids (~300 genes showed nonadditive expression compared to only 0.5% (16 genes in the non-heterotic hybrid. Of the nonadditively expressed genes, approximately 50% showed expression levels that fell outside the parental range in heterotic hybrids, but only one of 16 showed a similar profile in the non-heterotic hybrid. Genes whose expression differed in the parents were three times more likely to show nonadditive expression than genes whose parental transcript levels were equal. Conclusion The higher proportions of probe sets with expression level that differed from the parental midparent value and that were more extreme than either parental value in the heterotic hybrids compared to a non-heterotic hybrid were also found using RMA. We conclude that nonadditive expression of transcript levels may contribute to heterosis for biomass

  3. Hybrid Capture-Based Comprehensive Genomic Profiling Identifies Lung Cancer Patients with Well-Characterized Sensitizing Epidermal Growth Factor Receptor Point Mutations That Were Not Detected by Standard of Care Testing.

    Science.gov (United States)

    Suh, James H; Schrock, Alexa B; Johnson, Adrienne; Lipson, Doron; Gay, Laurie M; Ramkissoon, Shakti; Vergilio, Jo-Anne; Elvin, Julia A; Shakir, Abdur; Ruehlman, Peter; Reckamp, Karen L; Ou, Sai-Hong Ignatius; Ross, Jeffrey S; Stephens, Philip J; Miller, Vincent A; Ali, Siraj M

    2018-03-14

    In our recent study, of cases positive for epidermal growth factor receptor ( EGFR ) exon 19 deletions using comprehensive genomic profiling (CGP), 17/77 (22%) patients with prior standard of care (SOC) EGFR testing results available were previously negative for exon 19 deletion. Our aim was to compare the detection rates of CGP versus SOC testing for well-characterized sensitizing EGFR point mutations (pm) in our 6,832-patient cohort. DNA was extracted from 40 microns of formalin-fixed paraffin-embedded sections from 6,832 consecutive cases of non-small cell lung cancer (NSCLC) of various histologies (2012-2015). CGP was performed using a hybrid capture, adaptor ligation-based next-generation sequencing assay to a mean coverage depth of 576×. Genomic alterations (pm, small indels, copy number changes and rearrangements) involving EGFR were recorded for each case and compared with prior testing results if available. Overall, there were 482 instances of EGFR exon 21 L858R (359) and L861Q (20), exon 18 G719X (73) and exon 20 S768I (30) pm, of which 103 unique cases had prior EGFR testing results that were available for review. Of these 103 cases, CGP identified 22 patients (21%) with sensitizing EGFR pm that were not detected by SOC testing, including 9/75 (12%) patients with L858R, 4/7 (57%) patients with L861Q, 8/20 (40%) patients with G719X, and 4/7 (57%) patients with S768I pm (some patients had multiple EGFR pm). In cases with available clinical data, benefit from small molecule inhibitor therapy was observed. CGP, even when applied to low tumor purity clinical-grade specimens, can detect well-known EGFR pm in NSCLC patients that would otherwise not be detected by SOC testing. Taken together with EGFR exon 19 deletions, over 20% of patients who are positive for EGFR -activating mutations using CGP are previously negative by SOC EGFR mutation testing, suggesting that thousands of such patients per year in the U.S. alone could experience improved clinical

  4. Fast ion profiles during neutral beam and lower hybrid heating

    International Nuclear Information System (INIS)

    Heidbrink, W.W.; Strachan, J.D.; Bell, R.E.; Cavallo, A.; Motley, R.; Schilling, G.; Stevens, J.; Wilson, J.R.

    1985-07-01

    Profiles of the d(d,p)t fusion reaction are measured in the PLT tokamak using an array of collimated 3 MeV proton detectors. During deuterium neutral beam injection, the emission profile indicates that the beam deposition is at least as narrow as predicted by a bounce-averaged Fokker-Planck code. The fast ion tail formed by lower hybrid waves (at densities above the critical density for current drive) also peaks strongly near the magnetic axis

  5. The impact of hybridization on the volatile and sensorial profile of Ocimum basilicum L.

    Science.gov (United States)

    da Costa, Andréa Santos; Arrigoni-Blank, Maria de Fátima; da Silva, Maria Aparecida Azevedo Pereira; Alves, Mércia Freitas; Santos, Darlisson de Alexandria; Alves, Péricles Barreto; Blank, Arie Fitzgerald

    2014-01-01

    The aim of the present study was to investigate the volatile and sensorial profile of basil (Ocimum basilicum L.) by quantitative descriptive analysis (QDA) of the essential oil of three hybrids ("Cinnamon" × "Maria Bonita," "Sweet Dani" × "Cinnamon," and "Sweet Dani" × "Maria Bonita"). Twelve descriptive terms were developed by a selected panel that also generated the definition of each term and the reference samples. The data were subjected to ANOVA, Tukey's test, and principal component analysis. The hybrid "Cinnamon" × "Maria Bonita" exhibited a stronger global aroma that was less citric than the other samples. Hybridization favored the generation of novel compounds in the essential oil of the hybrid "Sweet Dani" × "Maria Bonita," such as canfora and (E)-caryophyllene; (E)-caryophyllene also was a novel compound in the hybrid "Sweet Dani" × "Cinnamon"; this compound was not present in the essential oils of the parents.

  6. Hybrid Electric Vehicle Testing | Transportation Research | NREL

    Science.gov (United States)

    Hybrid Electric Vehicle Evaluations Hybrid Electric Vehicle Evaluations How Hybrid Electric Vehicles Work Hybrid electric vehicles combine a primary power source, an energy storage system, and an is used to propel the vehicle during normal drive cycles. The batteries supply additional power for

  7. Feedback control of the lower hybrid power deposition profile on Tore Supra

    International Nuclear Information System (INIS)

    Barana, O; Mazon, D; Laborde, L; Turco, F

    2007-01-01

    The Tore Supra facility is well suited to study ITER relevant topics such as the real-time control of plasma current and the sustaining of steady-state discharges. This work describes a tool that was recently developed and implemented on Tore Supra to control in real time, by means of the direct knowledge of the suprathermal electron local emission profile, the width of the lower hybrid power deposition profile. This quantity can be considered to some extent equivalent to the width of the plasma current density profile in case of fully non-inductive discharges. This system takes advantage of an accurate hard x-ray diagnostics, of an efficient lower hybrid additional heating and of a reliable real-time communication network. The successful experiments carried out to test the system employed, as actuators, the parallel refractive index n // and the total power P LH . The control of the suprathermal electron local emission profile through n // was also integrated with the feedback control of the total plasma current I P with P LH and of the loop voltage V loop with the central solenoid flux. These results demonstrate that the system is robust, reliable and able to counterbalance destabilizing events. This tool can be effectively used in the future in fully non-inductive discharges to improve the MHD stability and to maintain internal transport barriers or lower hybrid enhanced performance modes. The real-time control of the lower hybrid power deposition profile could also be used in conjunction with the electron-cyclotron radiofrequency heating for synergy studies

  8. Pressure Drop Test of Hybrid Mixing Vane Spacer Grid

    Energy Technology Data Exchange (ETDEWEB)

    Oh, D. S.; Chang, S. K.; Kim, B. D.; Chun, S. Y.; Chun, T. H

    2007-08-15

    The pressure loss test has been accomplished in the test section containing 5x5 rod bundle with a length of 2 m including 3 spacer grids. The test has been performed for the 5 kinds of spacer grids to compare the pressure loss characteristics: 1. Plain spacer grid which has the same body of the Hybrid but without vane (Plain), 2. Hybrid Vane spacer grid (Hybrid), 3. Hybrid-SC spacer grid which is constructed with coined, chamfered strip and is fabricated by spot welding, 4. Hybrid-LC spacer grid which is constructed with coined, chamfered strip and is fabricated by line welding along intersection line, 5. Westinghouse spacer grid with split vane (Plus-7). The pressure loss coefficient of the Plain, Hybrid, Hybrid-SC, Hybrid-LC, and Plus-7 spacer grid is 0.93, 1.15, 1.02, 1.04, and 1.08, respectively.

  9. A Test Setup for Quality Assurance of Front End Hybrids

    CERN Document Server

    Axer, Markus; Camps, Clemens; Commichau, Volker; Flügge, Günter; Franke, Torsten; Hangarter, Klaus; Ilgin, Can; Mnich, Joachim; Niehusmann, Jan; Poettgens, Michael; Schorn, Peter; Schulte, Reiner; Struczinski, Wolfgang

    2001-01-01

    The APV Readout Control (ARC) Test Setup is a compact, cost efficient test and diagnostic tool which is suited for full operation and characterisation of FE hybrids and Si-Detector modules. This note gives an overview of the construction and the features of the test facility. Based on the ARC setup and the experience gained with one prototype FE hybrid, possible quality assurance scenarios for short and long term tests of FE hybrids are also presented.

  10. Hybrid Testing of Composite Structures with Single-Axis Control

    DEFF Research Database (Denmark)

    Waldbjørn, Jacob Paamand; Høgh, Jacob Herold; Stang, Henrik

    2013-01-01

    Correlation (DIC) is therefore implemented for displacement control of the experimental setup. The hybrid testing setup was verified on a multicomponent structure consisting of a beam loaded in three point bending and a numerical structure of a frame. Furthermore, the stability of the hybrid testing loop......Hybrid testing is a substructuring technique where a structure is emulated by modelling a part of it in a numerical model while testing the remainder experimentally. Previous research in hybrid testing has been performed on multi-component structures e.g. damping fixtures, however in this paper...... a hybrid testing platform is introduced for single-component hybrid testing. In this case, the boundary between the numerical model and experimental setup is defined by multiple Degrees-Of-Freedoms (DOFs) which highly complicate the transferring of response between the two substructures. Digital Image...

  11. Multi-machine transport analysis of hybrid discharges from the ITPA Profile Database

    International Nuclear Information System (INIS)

    Imbreaux, F.; Fujita, T.; Isayama, A.; Joffrin, E.; Kinsey, J.; Litaudon, X.; Luce, T.; Murakami, M.; Na, Y. S.; Sakamoto, Y.; Slips, A. C. C. C.; Wade, M.; Artaud, J. F.; Basiuk, V.

    2005-01-01

    The so-called Hybrid regime is a promising candidate scenario for ITER with a potential for longer inductive pulse at high fusion gain. Hybrid discharges are operated at higher q95 than the conventional H modes, which increases the non-inductive current fraction and the duration of the discharge. Another important characteristics of this regime is the absence of large sawteeth owing toa q-profile generally just above one in the plasma core. This property allows to reach high values of the normalised kinetic to magnetic pressure ratio β N =βaB T /I p of the order of 3, without triggering deleterious Neoclassical Tearing Modes. This work presents results of transport modelling of hybrid discharges from various tokamaks (Asdes Upgrade, DIII-D, JET, JT-60U) which have been submitted recently to the ITPA database. The objective is to assess the commonality of the transport physics in the hybrid regimes obtained by the various machines. The study focuses on the dependence of the transport properties as a function of important parameters like the density and the normalised Larmor radios ρ. Induced, those parameters play a critical role in the extrapolation of the transport characteristics of present day experiments to ITER. Various transport models are used in order to test their capability to reproduce the experimental parametric dependences on density and ρ. The extrapolability of the hybrid regime to ITER is checked using integrated modeling. (Author)

  12. The Impact of Hybridization on the Volatile and Sensorial Profile of Ocimum basilicum L.

    Directory of Open Access Journals (Sweden)

    Andréa Santos da Costa

    2014-01-01

    Full Text Available The aim of the present study was to investigate the volatile and sensorial profile of basil (Ocimum basilicum L. by quantitative descriptive analysis (QDA of the essential oil of three hybrids (“Cinnamon” × “Maria Bonita,” “Sweet Dani” × “Cinnamon,” and “Sweet Dani” × “Maria Bonita”. Twelve descriptive terms were developed by a selected panel that also generated the definition of each term and the reference samples. The data were subjected to ANOVA, Tukey’s test, and principal component analysis. The hybrid “Cinnamon” × “Maria Bonita” exhibited a stronger global aroma that was less citric than the other samples. Hybridization favored the generation of novel compounds in the essential oil of the hybrid “Sweet Dani” × “Maria Bonita,” such as canfora and (E-caryophyllene; (E-caryophyllene also was a novel compound in the hybrid “Sweet Dani” × “Cinnamon”; this compound was not present in the essential oils of the parents.

  13. Suspended Solids Profiler Shop Test Report

    International Nuclear Information System (INIS)

    STAEHR, T.W.

    2000-01-01

    The Suspended Solids Profiler (SSP) Instrument is planned to be installed in the AZ-101 tank to measure suspended solids concentrations during mixer pump testing. The SSP sensor uses a reflectance measurement principle to determine the suspended solids concentrations. The purpose of this test is to provide a documented means of verifying that the functional components of the SSP operate properly

  14. The Impact of Hybridization on the Volatile and Sensorial Profile of Ocimum basilicum L.

    OpenAIRE

    Andréa Santos da Costa; Maria de Fátima Arrigoni-Blank; Maria Aparecida Azevedo Pereira da Silva; Mércia Freitas Alves; Darlisson de Alexandria Santos; Péricles Barreto Alves; Arie Fitzgerald Blank

    2014-01-01

    The aim of the present study was to investigate the volatile and sensorial profile of basil (Ocimum basilicum L.) by quantitative descriptive analysis (QDA) of the essential oil of three hybrids (“Cinnamon” × “Maria Bonita,” “Sweet Dani” × “Cinnamon,” and “Sweet Dani” × “Maria Bonita”). Twelve descriptive terms were developed by a selected panel that also generated the definition of each term and the reference samples. The data were subjected to ANOVA, Tukey's test, and principal component an...

  15. Development and testing of a bipolar lead-acid battery for hybrid electric vehicles

    NARCIS (Netherlands)

    Saakes, M.; Kluiters, E.; Schmal, D.; Mourad, S.; Have, P.T.J.H. ten

    1999-01-01

    An 80 V bipolar lead-acid battery was constructed and tested using hybrid electric vehicle (HEV) drive cycles. Drive cycles with a peak power of 6.7 kW, equal to 1/5 of the total power profile required for the HEV studied, were run successfully. Model calculations showed that the 80 V module

  16. Reduction Methods for Real-time Simulations in Hybrid Testing

    DEFF Research Database (Denmark)

    Andersen, Sebastian

    2016-01-01

    Hybrid testing constitutes a cost-effective experimental full scale testing method. The method was introduced in the 1960's by Japanese researchers, as an alternative to conventional full scale testing and small scale material testing, such as shake table tests. The principle of the method...... is performed on a glass fibre reinforced polymer composite box girder. The test serves as a pilot test for prospective real-time tests on a wind turbine blade. The Taylor basis is implemented in the test, used to perform the numerical simulations. Despite of a number of introduced errors in the real...... is to divide a structure into a physical substructure and a numerical substructure, and couple these in a test. If the test is conducted in real-time it is referred to as real time hybrid testing. The hybrid testing concept has developed significantly since its introduction in the 1960', both with respect...

  17. Dynamic force profile in hydraulic hybrid vehicles: a numerical investigation

    Science.gov (United States)

    Mohaghegh-Motlagh, Amin; Elahinia, Mohammad H.

    2010-04-01

    A hybrid hydraulic vehicle (HHV) combines a hydraulic sub-system with the conventional drivetrain in order to improve fuel economy for heavy vehicles. The added hydraulic module manages the storage and release of fluid power necessary to assist the motion of the vehicle. The power collected by a pump/motor (P/M) from the regenerative braking phase is stored in a high-pressure accumulator and then released by the P/M to the driveshaft during the acceleration phase. This technology is effective in significantly improving fuel-economy for heavy-class vehicles with frequent stop-and-go drive schedules. Despite improved fuel economy and higher vehicle acceleration, noise and vibrations are one of the main problems of these vehicles. The dual function P/Ms are the main source of noise and vibration in a HHV. This study investigates the dynamics of a P/M and particularly the profile and frequency-dependence of the dynamic forces generated by a bent-axis P/M unit. To this end, the fluid dynamics side of the problem has been simplified for investigating the system from a dynamics perspective. A mathematical model of a bent axis P/M has been developed to investigate the cause of vibration and noise in HHVs. The forces are calculated in time and frequency domains. The results of this work can be used to study the vibration response of the chassis and to design effective vibration isolation systems for HHVs.

  18. Hybrid Design, Procurement and Testing for the LHCb Silicon Tracker

    CERN Document Server

    Bay, A; Frei, R; Jiménez-Otero, S; Perrin, A; Tran, MT; Van Hunen, J J; Vervink, K; Vollhardt, A; Agari, M; Bauer, C; Blouw, J; Hofmann, W; Knöpfle, K T; Löchner, S; Schmelling, M; Schwingenheuer, B; Smale, N J; Adeva, B; Esperante-Pereira, D; Lois, C; Vázquez, P; Lehner, F; Bernhard, R P; Bernet, R; Gassner, J; Köstner, S; Needham, M; Steinkamp, O; Straumann, U; Volyanskyy, D; Voss, H; Wenger, A

    2005-01-01

    The Silicon Tracker of the LHCb experiment consists of four silicon detector stations positioned along the beam line of the experiment. The detector modules of each station are constructed from wide pitch silicon microstrip sensors. Located at the module's end, a polyimide hybrid is housing the front-end electronics. The assembly of the more than 600 hybrids has been outsourced to industry. We will report on the design and production status of the hybrids for the LHCb Silicon Tracker and describe the quality assurance tests. Particular emphasis is laid on the vendor qualifying and its impact on our hybrid design that we experienced during the prototyping phase.

  19. Fatigue Testing of Maglev-Hybrid Box Beam

    Science.gov (United States)

    2009-03-02

    04142009 3. DATES COVERED: (From - To) 23052006-14092008 4. TITLE AND SUBTITLE Fatigue Testing of Maglev -Hybrid Box Beam 5a. CONTRACT NUMBER NA...was previously built under collaboration between Maglev Inc. and Lehigh University. The girder was instrumented with strain gages and LVDT’s to monitor...report March 2,2009 Contract N00014-06-1-0872 Project: Fatigue Testing of Maglev -Hybrid Box Beam Prepared by Dr. J.L. Grenestedt and Dr. R. Sause

  20. Nuclear Hybrid Energy System Model Stability Testing

    Energy Technology Data Exchange (ETDEWEB)

    Greenwood, Michael Scott [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Cetiner, Sacit M. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Fugate, David W. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2017-04-01

    A Nuclear Hybrid Energy System (NHES) uses a nuclear reactor as the basic power generation unit, and the power generated is used by multiple customers as combinations of thermal power or electrical power. The definition and architecture of a particular NHES can be adapted based on the needs and opportunities of different localities and markets. For example, locations in need of potable water may be best served by coupling a desalination plant to the NHES. Similarly, a location near oil refineries may have a need for emission-free hydrogen production. Using the flexible, multi-domain capabilities of Modelica, Argonne National Laboratory, Idaho National Laboratory, and Oak Ridge National Laboratory are investigating the dynamics (e.g., thermal hydraulics and electrical generation/consumption) and cost of a hybrid system. This paper examines the NHES work underway, emphasizing the control system developed for individual subsystems and the overall supervisory control system.

  1. Hydraulic Hybrid Parcel Delivery Truck Deployment, Testing & Demonstration

    Energy Technology Data Exchange (ETDEWEB)

    Gallo, Jean-Baptiste [Calstart Incorporated, Pasadena, CA (United States)

    2014-03-07

    Although hydraulic hybrid systems have shown promise over the last few years, commercial deployment of these systems has primarily been limited to Class 8 refuse trucks. In 2005, the Hybrid Truck Users Forum initiated the Parcel Delivery Working Group including the largest parcel delivery fleets in North America. The goal of the working group was to evaluate and accelerate commercialization of hydraulic hybrid technology for parcel delivery vehicles. FedEx Ground, Purolator and United Parcel Service (UPS) took delivery of the world’s first commercially available hydraulic hybrid parcel delivery trucks in early 2012. The vehicle chassis includes a Parker Hannifin hydraulic hybrid drive system, integrated and assembled by Freightliner Custom Chassis Corp., with a body installed by Morgan Olson. With funding from the U.S. Department of Energy, CALSTART and its project partners assessed the performance, reliability, maintainability and fleet acceptance of three pre-production Class 6 hydraulic hybrid parcel delivery vehicles using information and data from in-use data collection and on-road testing. This document reports on the deployment of these vehicles operated by FedEx Ground, Purolator and UPS. The results presented provide a comprehensive overview of the performance of commercial hydraulic hybrid vehicles in parcel delivery applications. This project also informs fleets and manufacturers on the overall performance of hydraulic hybrid vehicles, provides insights on how the technology can be both improved and more effectively used. The key findings and recommendations of this project fall into four major categories: -Performance, -Fleet deployment, -Maintenance, -Business case. Hydraulic hybrid technology is relatively new to the market, as commercial vehicles have been introduced only in the past few years in refuse and parcel delivery applications. Successful demonstration could pave the way for additional purchases of hydraulic hybrid vehicles throughout the

  2. Hybrid microcircuit technology handbook materials, processes, design, testing and production

    CERN Document Server

    Licari, James J

    1998-01-01

    The Hybrid Microcircuit Technology Handbook integrates the many diverse technologies used in the design, fabrication, assembly, and testing of hybrid segments crucial to the success of producing reliable circuits in high yields. Among these are: resistor trimming, wire bonding, die attachment, cleaning, hermetic sealing, and moisture analysis. In addition to thin films, thick films, and assembly processes, important chapters on substrate selections, handling (including electrostatic discharge), failure analysis, and documentation are included. A comprehensive chapter of design guidelines will

  3. Closed-loop thrust and pressure profile throttling of a nitrous oxide/hydroxyl-terminated polybutadiene hybrid rocket motor

    Science.gov (United States)

    Peterson, Zachary W.

    Hybrid motors that employ non-toxic, non-explosive components with a liquid oxidizer and a solid hydrocarbon fuel grain have inherently safe operating characteristics. The inherent safety of hybrid rocket motors offers the potential to greatly reduce overall operating costs. Another key advantage of hybrid rocket motors is the potential for in-flight shutdown, restart, and throttle by controlling the pressure drop between the oxidizer tank and the injector. This research designed, developed, and ground tested a closed-loop throttle controller for a hybrid rocket motor using nitrous oxide and hydroxyl-terminated polybutadiene as propellants. The research simultaneously developed closed-loop throttle algorithms and lab scale motor hardware to evaluate the fidelity of the throttle simulations and algorithms. Initial open-loop motor tests were performed to better classify system parameters and to validate motor performance values. Deep-throttle open-loop tests evaluated limits of stable thrust that can be achieved on the test hardware. Open-loop tests demonstrated the ability to throttle the motor to less than 10% of maximum thrust with little reduction in effective specific impulse and acoustical stability. Following the open-loop development, closed-loop, hardware-in-the-loop tests were performed. The closed-loop controller successfully tracked prescribed step and ramp command profiles with a high degree of fidelity. Steady-state accuracy was greatly improved over uncontrolled thrust.

  4. Towards the development of a hybrid-integrated chip interferometer for online surface profile measurements

    International Nuclear Information System (INIS)

    Kumar, P.; Martin, H.; Jiang, X.

    2016-01-01

    Non-destructive testing and online measurement of surface features are pressing demands in manufacturing. Thus optical techniques are gaining importance for characterization of complex engineering surfaces. Harnessing integrated optics for miniaturization of interferometry systems onto a silicon wafer and incorporating a compact optical probe would enable the development of a handheld sensor for embedded metrology applications. In this work, we present the progress in the development of a hybrid photonics based metrology sensor device for online surface profile measurements. The measurement principle along with test and measurement results of individual components has been presented. For non-contact measurement, a spectrally encoded lateral scanning probe based on the laser scanning microscopy has been developed to provide fast measurement with lateral resolution limited to the diffraction limit. The probe demonstrates a lateral resolution of ∼3.6 μm while high axial resolution (sub-nanometre) is inherently achieved by interferometry. Further the performance of the hybrid tuneable laser and the scanning probe was evaluated by measuring a standard step height sample of 100 nm.

  5. Towards the development of a hybrid-integrated chip interferometer for online surface profile measurements

    Energy Technology Data Exchange (ETDEWEB)

    Kumar, P.; Martin, H.; Jiang, X. [EPSRC Centre for Innovative Manufacturing in Advanced Metrology, University of Huddersfield, Huddersfield HD1 3DH (United Kingdom)

    2016-06-15

    Non-destructive testing and online measurement of surface features are pressing demands in manufacturing. Thus optical techniques are gaining importance for characterization of complex engineering surfaces. Harnessing integrated optics for miniaturization of interferometry systems onto a silicon wafer and incorporating a compact optical probe would enable the development of a handheld sensor for embedded metrology applications. In this work, we present the progress in the development of a hybrid photonics based metrology sensor device for online surface profile measurements. The measurement principle along with test and measurement results of individual components has been presented. For non-contact measurement, a spectrally encoded lateral scanning probe based on the laser scanning microscopy has been developed to provide fast measurement with lateral resolution limited to the diffraction limit. The probe demonstrates a lateral resolution of ∼3.6 μm while high axial resolution (sub-nanometre) is inherently achieved by interferometry. Further the performance of the hybrid tuneable laser and the scanning probe was evaluated by measuring a standard step height sample of 100 nm.

  6. Testing hybrid natural inflation with BICEP2

    Energy Technology Data Exchange (ETDEWEB)

    Carrillo-González, Mariana [Instituto de Ciencias Físicas, Universidad Nacional Autónoma de México, Apdo. Postal 48-3, 62251 Cuernavaca, Morelos (Mexico); Germán, Gabriel, E-mail: gabriel@fis.unam.mx [Instituto de Ciencias Físicas, Universidad Nacional Autónoma de México, Apdo. Postal 48-3, 62251 Cuernavaca, Morelos (Mexico); Herrera-Aguilar, Alfredo [Departamento de Física, Universidad Autónoma Metropolitana Iztapalapa, San Rafael Atlixco 186, CP 09340, México D.F. (Mexico); Instituto de Física y Matemáticas, Universidad Michoacana de San Nicolás de Hidalgo, Edificio C-3, Ciudad Universitaria, CP 58040, Morelia, Michoacán (Mexico); Hidalgo, Juan Carlos [Instituto de Ciencias Físicas, Universidad Nacional Autónoma de México, Apdo. Postal 48-3, 62251 Cuernavaca, Morelos (Mexico); Sussman, Roberto A. [Instituto de Ciencias Nucleares, Universidad Nacional Autónoma de México, Apdo. Postal 70-543, 04510 México D.F. (Mexico)

    2014-06-27

    We analyse Hybrid Natural Inflation in view of the recent results for the tensor index reported by BICEP2. We find that it predicts a large running of the scalar spectrum which is potentially detectable by large scale structure through measurements of clustering of galaxies in combination with CMB data and by 21 cm forest observations. The running of the running is also relatively large becoming close to 10{sup −2}. Along the way, we find general consistency relations at which observables are subject if the slow-roll approximation is imposed. Failure to satisfy these equations by the values obtained for the observables in surveys would be a failure of the slow-roll approximation itself.

  7. Profile control simulations and experiments on TCV : A controller test environment and results using a model-based predictive controller

    NARCIS (Netherlands)

    Maljaars, E.; Felici, F.; Blanken, T.C.; Galperti, C.; Sauter, O.; de Baar, M.R.; Carpanese, F.; Goodman, T.P.; Kim, D.; Kim, S.H.; Kong, M.G.; Mavkov, B.; Merle, A.; Moret, J.M.; Nouailletas, R.; Scheffer, M.; Teplukhina, A.A.; Vu, N.M.T.

    2017-01-01

    The successful performance of a model predictive profile controller is demonstrated in simulations and experiments on the TCV tokamak, employing a profile controller test environment. Stable high-performance tokamak operation in hybrid and advanced plasma scenarios requires control over the safety

  8. Profile control simulations and experiments on TCV: a controller test environment and results using a model-based predictive controller

    NARCIS (Netherlands)

    Maljaars, B.; Felici, F.; Blanken, T. C.; Galperti, C.; Sauter, O.; de Baar, M. R.; Carpanese, F.; Goodman, T. P.; Kim, D.; Kim, S. H.; Kong, M.; Mavkov, B.; Merle, A.; Moret, J.; Nouailletas, R.; Scheffer, M.; Teplukhina, A.; Vu, T.

    2017-01-01

    The successful performance of a model predictive profile controller is demonstrated in simulations and experiments on the TCV tokamak, employing a profile controller test environment. Stable high-performance tokamak operation in hybrid and advanced plasma scenarios requires control over the safety

  9. Design, building and testing of a stand alone fuel cell hybrid system

    Energy Technology Data Exchange (ETDEWEB)

    Segura, F.; Duran, E.; Andujar, J.M. [Department of Electronic, Computer Science and Automatic Engineering, University of Huelva (Spain)

    2009-08-01

    This paper designs, sizes, builds and tests a stand alone fuel cell hybrid system made up of a fuel cell stack and a battery bank. This system has been sized to supply a typical telecommunication load profile, but moreover, the system can supply other profiles. For this purpose, a modular low cost electronic load bank has been designed and built. This load bank allows the power demand to be chosen by selecting different solid state relays. Moreover, a virtual instrument based on NI Labview {sup registered} has been designed to select the load power demand from the computer. (author)

  10. Effects of hybrid and bacterial inoculation on fermentation quality and fatty acid profile of barley silage.

    Science.gov (United States)

    Kim, Dong Hyeon; Amanullah, Sadar M; Lee, Hyuk Jun; Joo, Young Ho; Han, Ouk Kyu; Adesogan, Adegbola T; Kim, Sam Churl

    2018-01-01

    This study estimated the effects of hybrid and bacterial inoculant on fermentation quality and fatty acid profile of barley silages. Yuyeon (Silkless) and Youngyang (Silking) barley hybrids were harvested at 24.9 and 27.1% dry matter, respectively, and chopped to 10 cm lengths. Each hybrid was treated with or without an inoculant (2 × 10 4  colony-forming units/g of Lactobacillus plantarum). A total of 48 silos were prepared in an experiment with a 2 × 2 (hybrid × inoculant) treatment arrangement with four replications and three ensiling durations (2, 7 and 100 days). After 100 days of ensiling, Yuyeon silage had higher (P hybrids and increased (P hybrid might have better potential benefits on animal performances due to its smooth awn and silkless nature, and higher in vitro dry matter digestibility. Its higher C18:3n-3 would be better for improving fatty acid profile of meat or milk than Youngyang hybrid. © 2017 Japanese Society of Animal Science.

  11. Hybrid rocket motor testing at Nammo Raufoss A/S

    Science.gov (United States)

    Rønningen, Jan-Erik; Kubberud, Nils

    2005-08-01

    Hybrid rocket motor technology and the use of hybrid rockets have gained increased interest in recent years in many countries. A typical hybrid rocket consists of a tank containing the oxidizer in either liquid or gaseous state connected to the combustion chamber containing an injector, inert solid fuel grain and nozzle. Nammo Raufoss A/S has for almost 40 years designed and produced high-performance solid propellant rocket motors for many military missile systems as well as solid propellant rocket motors for civil space use. In 2003 an in-house technology program was initiated to investigate and study hybrid rocket technology. On 23 September 2004 the first in-house designed hybrid test rocket motor was static test fired at Nammo Raufoss Test Center. The oxidizer was gaseous oxygen contained in a tank pressurized to 10MPa, flow controlled through a sonic orifice into the combustion chamber containing a multi port radial injector and six bore cartridge-loaded fuel grain containing a modified HTPB fuel composition. The motor was ignited using a non-explosive heated wire. This paper will present what has been achieved at Nammo Raufoss since the start of the program.

  12. Hybrid and plug-in hybrid electric vehicle performance testing by the US Department of Energy Advanced Vehicle Testing Activity

    Science.gov (United States)

    Karner, Donald; Francfort, James

    The Advanced Vehicle Testing Activity (AVTA), part of the U.S. Department of Energy's FreedomCAR and Vehicle Technologies Program, has conducted testing of advanced technology vehicles since August 1995 in support of the AVTA goal to provide benchmark data for technology modeling, and vehicle development programs. The AVTA has tested full size electric vehicles, urban electric vehicles, neighborhood electric vehicles, and hydrogen internal combustion engine powered vehicles. Currently, the AVTA is conducting baseline performance, battery benchmark and fleet tests of hybrid electric vehicles (HEV) and plug-in hybrid electric vehicles (PHEV). Testing has included all HEVs produced by major automotive manufacturers and spans over 2.5 million test miles. Testing is currently incorporating PHEVs from four different vehicle converters. The results of all testing are posted on the AVTA web page maintained by the Idaho National Laboratory.

  13. Phylogenetic tests of a Cercopithecus monkey hybrid reveal X ...

    African Journals Online (AJOL)

    A captive Cercopithecus nictitans × C. cephus male was examined at loci on the X- and Y-chromosomes as a test of previously described phylogenetic methods for identifying hybrid Cercopithecus monkeys. The results confirm the reliability of such assays, indicating that they can be of immediate utility for studies of wild ...

  14. Testing a Fourier Accelerated Hybrid Monte Carlo Algorithm

    OpenAIRE

    Catterall, S.; Karamov, S.

    2001-01-01

    We describe a Fourier Accelerated Hybrid Monte Carlo algorithm suitable for dynamical fermion simulations of non-gauge models. We test the algorithm in supersymmetric quantum mechanics viewed as a one-dimensional Euclidean lattice field theory. We find dramatic reductions in the autocorrelation time of the algorithm in comparison to standard HMC.

  15. Calorimeter Preamplifier Hybrid Circuit Test Jig

    International Nuclear Information System (INIS)

    Abraham, B.M.

    1999-01-01

    There are two ways in which the testing may be initiated, remotely or locally. If the remote operation is desired, an external TTL level signal must be provided to the test jig with the remotellocal switch on the side of the test jig switched to remote. A logic high will initiate the test. A logic low will terminate the test. In the event that an external signal is connected to the test jig while local operation occurs, the local control takes precedence over remote control. Once a DVT has been locked in the ZIF socket and the DIP switches are selected, the Push-to-Test button may be depressed. Momentarily depressing the button will initiate a test with a minimum 400 ms duration. At the same time a PBCLOCK and PBLATCH pulses will be initiated and the power rails +12V, +8V, and -6V will be ramped to full voltage. The time at which the power rails reach the full voltage is about 13 ms and it is synchronized with bypass capacitors placed on COMP input of U20 and U22 and on the output of U23 voltage regulators. The voltage rails are supplied to a ±10% window comparator. A red LED indicates the rail is below or above 10% of the design value. A green LED indicates the rail is within acceptable limits. For DDT with a 5 pF and 10 pF feed back capacitor, the +12V and +8V rails are current-regulated to 19rnA and 22 rnA respectively and the -6V rail is short-circuit protected within the regulator. For DUT with a 22 pF feed back capacitor the current regulation is the same as above except that the +8V rail is current regulated to 43 rnA. The power rails are supplied to the DUT via a 10 (Omega) resistor. The voltage drop across this resistor is sensed by a differential amplifier AD620 and amplified by a gain of 10. An external BNC connection is provided from this point to allow for current measurements by the vendor. The current value for each rail is calculated by measuring the voltage value at this point and divided by (10*10(Omega)). The next stage inverts and amplifies the

  16. Calorimeter Preamplifier Hybrid Circuit Test Jig

    Energy Technology Data Exchange (ETDEWEB)

    Abraham, B.M.; /Fermilab

    1999-04-19

    There are two ways in which the testing may be initiated, remotely or locally. If the remote operation is desired, an external TTL level signal must be provided to the test jig with the remotellocal switch on the side of the test jig switched to remote. A logic high will initiate the test. A logic low will terminate the test. In the event that an external signal is connected to the test jig while local operation occurs, the local control takes precedence over remote control. Once a DVT has been locked in the ZIF socket and the DIP switches are selected, the Push-to-Test button may be depressed. Momentarily depressing the button will initiate a test with a minimum 400 ms duration. At the same time a PBCLOCK and PBLATCH pulses will be initiated and the power rails +12V, +8V, and -6V will be ramped to full voltage. The time at which the power rails reach the full voltage is about 13 ms and it is synchronized with bypass capacitors placed on COMP input of U20 and U22 and on the output of U23 voltage regulators. The voltage rails are supplied to a {+-}10% window comparator. A red LED indicates the rail is below or above 10% of the design value. A green LED indicates the rail is within acceptable limits. For DDT with a 5 pF and 10 pF feed back capacitor, the +12V and +8V rails are current-regulated to 19rnA and 22 rnA respectively and the -6V rail is short-circuit protected within the regulator. For DUT with a 22 pF feed back capacitor the current regulation is the same as above except that the +8V rail is current regulated to 43 rnA. The power rails are supplied to the DUT via a 10 {Omega} resistor. The voltage drop across this resistor is sensed by a differential amplifier AD620 and amplified by a gain of 10. An external BNC connection is provided from this point to allow for current measurements by the vendor. The current value for each rail is calculated by measuring the voltage value at this point and divided by (10*10{Omega}). The next stage inverts and amplifies

  17. Test Beam Results of Geometry Optimized Hybrid Pixel Detectors

    CERN Document Server

    Becks, K H; Grah, C; Mättig, P; Rohe, T

    2006-01-01

    The Multi-Chip-Module-Deposited (MCM-D) technique has been used to build hybrid pixel detector assemblies. This paper summarises the results of an analysis of data obtained in a test beam campaign at CERN. Here, single chip hybrids made of ATLAS pixel prototype read-out electronics and special sensor tiles were used. They were prepared by the Fraunhofer Institut fuer Zuverlaessigkeit und Mikrointegration, IZM, Berlin, Germany. The sensors feature an optimized sensor geometry called equal sized bricked. This design enhances the spatial resolution for double hits in the long direction of the sensor cells.

  18. Analysis of a Hybrid Wing Body Center Section Test Article

    Science.gov (United States)

    Wu, Hsi-Yung T.; Shaw, Peter; Przekop, Adam

    2013-01-01

    The hybrid wing body center section test article is an all-composite structure made of crown, floor, keel, bulkhead, and rib panels utilizing the Pultruded Rod Stitched Efficient Unitized Structure (PRSEUS) design concept. The primary goal of this test article is to prove that PRSEUS components are capable of carrying combined loads that are representative of a hybrid wing body pressure cabin design regime. This paper summarizes the analytical approach, analysis results, and failure predictions of the test article. A global finite element model of composite panels, metallic fittings, mechanical fasteners, and the Combined Loads Test System (COLTS) test fixture was used to conduct linear structural strength and stability analyses to validate the specimen under the most critical combination of bending and pressure loading conditions found in the hybrid wing body pressure cabin. Local detail analyses were also performed at locations with high stress concentrations, at Tee-cap noodle interfaces with surrounding laminates, and at fastener locations with high bearing/bypass loads. Failure predictions for different composite and metallic failure modes were made, and nonlinear analyses were also performed to study the structural response of the test article under combined bending and pressure loading. This large-scale specimen test will be conducted at the COLTS facility at the NASA Langley Research Center.

  19. ATLAS ABCD Hybrid Fatal Charge Dosage Test

    CERN Document Server

    Kuhl, A; The ATLAS collaboration; Grillo, AA; Martinez-McKinney, F; Nielsen, J; Spencer, E; Wilder, M

    2011-01-01

    The Semi-Conductor Tracker (SCT) in the ATLAS experiment at the Large Hadron Collider (LHC) could be subject to various beam loss scenarios. If a severe beam loss event were to occur, it would be beneficial to know how SCT components would be affected. In the SCT detector modules, a key component is the ABCD application specific integrated circuit (ASIC), the onboard readout electronics of the system. This ASIC has design specifications that it should withstand a 5nC charge injection within 25 ns, which is the period of the LHC bunch crossing. The first test performed is designed to test this limit, reaching a maximum of 10nC deposited in 25 ns. One model for beam loss predicts that a large charge, of the order of 10^6 MIPS, could be incident on the detector. According to detector studies, this causes a local field breakdown between the backplane of the sensor, held at 450V, and the strips. In this case the signal seen on the readout strip has a rise time of about 1μs due to a charge screening effect. A seco...

  20. ATLAS ABCD Hybrid Fatal Charge Dosage Test

    CERN Document Server

    Kuhl, A; Grillo, A A; Martinez-McKinney, F; Nielsen, J; Spencer, E; Wilder, M

    2011-01-01

    The Semi-Conductor Tracker (SCT) in the ATLAS experiment at the Large Hadron Collider (LHC) could be subject to various beam loss scenarios. If a severe beam loss event were to occur, it would be beneficial to know how SCT components would be affected. In the SCT detector modules, a key component is the ABCD application specific integrated circuit (ASIC), the onboard readout electronics of the system. This ASIC has design specifications that it should withstand a 5 nC charge application within 25 ns, which is the period of the LHC bunch crossing. The first test performed is designed to test this limit, reaching a maximum of 10 nC deposited in 25 ns. One model for beam loss predicts that a large charge, of the order of 106 MIPS, could be incident on the detector. According to detector studies, this causes a local field breakdown between the backplane of the sensor, held at 450 V, and the strips. In this case the signal seen on the readout strip has a rise time of about 1 μs due to a charge screening effect. A...

  1. Battery Test Manual For 48 Volt Mild Hybrid Electric Vehicles

    International Nuclear Information System (INIS)

    Walker, Lee Kenneth

    2017-01-01

    This manual details the U.S. Advanced Battery Consortium and U.S. Department of Energy Vehicle Technologies Program goals, test methods, and analysis techniques for a 48 Volt Mild Hybrid Electric Vehicle system. The test methods are outlined stating with characterization tests, followed by life tests. The final section details standardized analysis techniques for 48 V systems that allow for the comparison of different programs that use this manual. An example test plan is included, along with guidance to filling in gap table numbers.

  2. Battery Test Manual For 48 Volt Mild Hybrid Electric Vehicles

    Energy Technology Data Exchange (ETDEWEB)

    Walker, Lee Kenneth [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2017-03-01

    This manual details the U.S. Advanced Battery Consortium and U.S. Department of Energy Vehicle Technologies Program goals, test methods, and analysis techniques for a 48 Volt Mild Hybrid Electric Vehicle system. The test methods are outlined stating with characterization tests, followed by life tests. The final section details standardized analysis techniques for 48 V systems that allow for the comparison of different programs that use this manual. An example test plan is included, along with guidance to filling in gap table numbers.

  3. Variability in coconut (Cocos nucifera L.) germplasm and hybrids for fatty acid profile of oil.

    Science.gov (United States)

    Kumar, S Naresh

    2011-12-28

    Coconut oil, the main product of coconut fruit, is the richest source of glycerol and lauric acid and hence is called lauric oil. This paper reports the fatty acid profile of oil from 60 Talls, 14 Dwarfs, and 34 hybrids. These include collections from 13 countries covering a large coconut-growing area of the world, apart from the indigenous ones. Capillary gas chromatography analysis of oil indicated a wider variation for the fatty acid profile than earlier reported. Apart from this, for the first time other fatty acids such as behenic and lignoceric acids were detected. Oil from cultivars and hybrids of coconut has significantly differed, particularly for commercially important fatty acids such as lauric acid and unsaturated fatty acids. However, coconut oil seems to have a conserved fatty acid profile, mainly because of low unsaturated fatty acids, indicating the possibility of grouping cultivars on the basis of their fatty acid profiles. The cluster analysis based on fatty acid profile indicated grouping together of geographically and typically closely related cultivars. Cultivars with high concentrations of specific fatty acids can be of potential use for industrial exploitation, whereas those with high concentrations of short- and medium-chain fatty acids and unsaturated fatty acids are more suitable for human consumption. Cultivars and hybrids with high and low values for each of the fatty acids are also identified.

  4. Application of the X-in-the-Loop Testing Method in the FCV Hybrid Degree Test

    Directory of Open Access Journals (Sweden)

    Haiyu Gao

    2018-02-01

    Full Text Available With the development of fuel cell vehicle technology, an effective testing method that can be applied to develop and verify the fuel cell vehicle powertrain system is urgently required. This paper presents the X-in-the-Loop (XiL testing method in the fuel cell vehicle (FCV hybrid degree test to resolve the first and key issues for the powertrain system design, and the test process and scenarios were designed. The hybrid degree is redefined into the static hybrid degree for system architecture design and the dynamic hybrid degree for vehicle control strategy design, and an integrated testing platform was introduced and a testing application was implemented by following the designed testing flowchart with two loops. Experimental validations show that the sizing of the FCE (Fuel Cell Engine, battery pack, and traction motor with the powertrain architecture can be determined, the control strategy can be evaluated seamlessly, and a systematic powertrain testing solution can be achieved through the whole development process. This research has developed a new testing platform and proposed a novel testing method on the fuel cell vehicle powertrain system, which will be a contribution to fuel cell vehicle technology and its industrialization.

  5. 75 FR 76636 - Anthropomorphic Test Devices; Hybrid III 6-Year-Old Child Test Dummy, Hybrid III 6-Year-Old...

    Science.gov (United States)

    2010-12-09

    ... provision: ``When a motor vehicle safety standard is in effect under this chapter, a State or a political... [Docket No. NHTSA-2010-0147] RIN 2127-AK34 Anthropomorphic Test Devices; Hybrid III 6-Year-Old Child Test Dummy, Hybrid III 6-Year-Old Weighted Child Test Dummy AGENCY: National Highway Traffic Safety...

  6. Lexical Profiles of Thailand University Admission Tests

    Science.gov (United States)

    Cherngchawano, Wirun; Jaturapitakkul, Natjiree

    2014-01-01

    University Admission Tests in Thailand are important documents which reflect Thailand's education system. To study at a higher education level, all students generally need to take the University Admission Tests designed by the National Institute of Educational Testing Service (NIETS). For the English test, vocabulary and reading comprehension is…

  7. Numerical optimization of actuator trajectories for ITER hybrid scenario profile evolution

    International Nuclear Information System (INIS)

    Dongen, J van; Hogeweij, G M D; Felici, F; Geelen, P; Maljaars, E

    2014-01-01

    Optimal actuator trajectories for an ITER hybrid scenario ramp-up are computed using a numerical optimization method. For both L-mode and H-mode scenarios, the time trajectory of plasma current, EC heating and current drive distribution is determined that minimizes a chosen cost function, while satisfying constraints. The cost function is formulated to reflect two desired properties of the plasma q profile at the end of the ramp-up. The first objective is to maximize the ITG turbulence threshold by maximizing the volume-averaged s/q ratio. The second objective is to achieve a stationary q profile by having a flat loop voltage profile. Actuator and physics-derived constraints are included, imposing limits on plasma current, ramp rates, internal inductance and q profile. This numerical method uses the fast control-oriented plasma profile evolution code RAPTOR, which is successfully benchmarked against more complete CRONOS simulations for L-mode and H-mode mode ITER hybrid scenarios. It is shown that the optimized trajectories computed using RAPTOR also result in an improved ramp-up scenario for CRONOS simulations using the same input trajectories. Furthermore, the optimal trajectories are shown to vary depending on the precise timing of the L–H transition. (paper)

  8. Solid-to-hybrid transitioning armature railgun with non-conforming-to-prejudice bore profile

    Science.gov (United States)

    Solberg, Jerome Michael

    2012-12-04

    An improved railgun, railgun barrel, railgun projectile, and railgun system for accelerating a solid-to-hybrid transitioning armature projectile using a barrel having a bore that does not conform to a cross-sectional profile of the projectile, to contact and guide the projectile only by the rails in a low pressure bore volume so as to minimize damage, failure, and/or underperformance caused by plasma armatures, insulator ablation, and/or restrikes.

  9. Multi-machine transport analysis of hybrid discharges from the ITPA profile database

    International Nuclear Information System (INIS)

    Artaud, J.F.; Bourdelle, C.; Joffrin, E.; Kinsey, J.; Tala, T.J.J.; Fujita, T.; Sakamoto, Y.; Na, Y.S.; Sips, A.C.C.; Na, Y.S.; Parail, V.V.

    2005-01-01

    Current diffusion, heat transport modelling, and linear gyrokinetic stability analysis have been carried out on a set of 7 hybrid discharges from AUG, DIII-D, JET and JT-60U, in order to gain better understanding of the physics underlying this promising candidate scenario for ITER. Within this dataset, the GLF23 model has a higher accuracy than the Weiland model in predicting the temperature profiles in the region 0.3 N on extended duration. (authors)

  10. Interrupter and hybrid-switch testing for fusion devices

    International Nuclear Information System (INIS)

    Parsons, W.M.; Warren, R.W.; Honig, E.M.; Lindsay, J.D.G.; Bellamo, P.; Cassel, R.L.

    1979-01-01

    This paper discusses recent and ongoing switch testing for fusion devices. The first part describes testing for the TFTR ohmic-heating circuit. In this set of tests, which simulated the stresses produced during a plasma initiation pulse, circuit breakers were required to interrupt a current of 24 kA with an associated recovery voltage of 25 kV. Two interrupter systems were tested for over 1000 operations each, and both appear to satisfy TFTR requirements. The second part discusses hybrid-switch development for superconducting coil protection. These switching systems must be capable of carrying large currents on a continuous basis as well as performing interruption duties. The third part presents preliminary results on an early-counterpulse technique applied to vacuum interrupters. Implementation of this technique has resulted in large increases in interruptible current as well as a marked reduction in contact erosion

  11. Finite Element Analysis and Test Results Comparison for the Hybrid Wing Body Center Section Test Article

    Science.gov (United States)

    Przekop, Adam; Jegley, Dawn C.; Rouse, Marshall; Lovejoy, Andrew E.

    2016-01-01

    This report documents the comparison of test measurements and predictive finite element analysis results for a hybrid wing body center section test article. The testing and analysis efforts were part of the Airframe Technology subproject within the NASA Environmentally Responsible Aviation project. Test results include full field displacement measurements obtained from digital image correlation systems and discrete strain measurements obtained using both unidirectional and rosette resistive gauges. Most significant results are presented for the critical five load cases exercised during the test. Final test to failure after inflicting severe damage to the test article is also documented. Overall, good comparison between predicted and actual behavior of the test article is found.

  12. NASA Hybrid Wing Aircraft Aeroacoustic Test Documentation Report

    Science.gov (United States)

    Heath, Stephanie L.; Brooks, Thomas F.; Hutcheson, Florence V.; Doty, Michael J.; Bahr, Christopher J.; Hoad, Danny; Becker, Lawrence; Humphreys, William M.; Burley, Casey L.; Stead, Dan; hide

    2016-01-01

    This report summarizes results of the Hybrid Wing Body (HWB) N2A-EXTE model aeroacoustic test. The N2A-EXTE model was tested in the NASA Langley 14- by 22-Foot Subsonic Tunnel (14x22 Tunnel) from September 12, 2012 until January 28, 2013 and was designated as test T598. This document contains the following main sections: Section 1 - Introduction, Section 2 - Main Personnel, Section 3 - Test Equipment, Section 4 - Data Acquisition Systems, Section 5 - Instrumentation and Calibration, Section 6 - Test Matrix, Section 7 - Data Processing, and Section 8 - Summary. Due to the amount of material to be documented, this HWB test documentation report does not cover analysis of acquired data, which is to be presented separately by the principal investigators. Also, no attempt was made to include preliminary risk reduction tests (such as Broadband Engine Noise Simulator and Compact Jet Engine Simulator characterization tests, shielding measurement technique studies, and speaker calibration method studies), which were performed in support of this HWB test. Separate reports containing these preliminary tests are referenced where applicable.

  13. Hydraulic Hybrid Fleet Vehicle Testing | Transportation Research | NREL

    Science.gov (United States)

    Hydraulic Hybrid Fleet Vehicle Evaluations Hydraulic Hybrid Fleet Vehicle Evaluations How Hydraulic Hybrid Vehicles Work Hydraulic hybrid systems can capture up to 70% of the kinetic energy that would -pressure reservoir to a high-pressure accumulator. When the vehicle accelerates, fluid in the high-pressure

  14. Executive Functioning Profiles and Test Anxiety in College Students

    Science.gov (United States)

    O'Donnell, Patrick S.

    2017-01-01

    The current study attempted to answer whether a specific executive functioning profile for individuals with test anxiety exists and whether deficits in working memory are associated with an earlier onset of test anxiety. Two hundred eighty-four undergraduate students completed a survey on test anxiety and self-report measures of test anxiety and…

  15. Hybrid Wing Body Aircraft Acoustic Test Preparations and Facility Upgrades

    Science.gov (United States)

    Heath, Stephanie L.; Brooks, Thomas F.; Hutcheson, Florence V.; Doty, Michael J.; Haskin, Henry H.; Spalt, Taylor B.; Bahr, Christopher J.; Burley, Casey L.; Bartram, Scott M.; Humphreys, William M.; hide

    2013-01-01

    NASA is investigating the potential of acoustic shielding as a means to reduce the noise footprint at airport communities. A subsonic transport aircraft and Langley's 14- by 22-foot Subsonic Wind Tunnel were chosen to test the proposed "low noise" technology. The present experiment studies the basic components of propulsion-airframe shielding in a representative flow regime. To this end, a 5.8-percent scale hybrid wing body model was built with dual state-of-the-art engine noise simulators. The results will provide benchmark shielding data and key hybrid wing body aircraft noise data. The test matrix for the experiment contains both aerodynamic and acoustic test configurations, broadband turbomachinery and hot jet engine noise simulators, and various airframe configurations which include landing gear, cruise and drooped wing leading edges, trailing edge elevons and vertical tail options. To aid in this study, two major facility upgrades have occurred. First, a propane delivery system has been installed to provide the acoustic characteristics with realistic temperature conditions for a hot gas engine; and second, a traversing microphone array and side towers have been added to gain full spectral and directivity noise characteristics.

  16. Lower hybrid wave accessibility as a means for current profile control

    International Nuclear Information System (INIS)

    Briffod, G.; Gormezano, C.; Parlange, F.; Van Houtte, D.

    1986-01-01

    Powerful ICRH experiments on JET and Neutral Beam Injection of various species on TFTR have recently confirmed the insensitivity of the temperature and safety factor profile shapes to the heating profile and the important role played by the sawtooth activity on the overall performances. In order to overcome these limitations, we propose in this paper, in a Tokamak operating at constant plasma current: to control the resistive part of the current by driving an H.F. current by Lower Hybrid Wave. To act on the current profile, with the constraint that q(o) > 1 by controlling the wave penetration. Constant plasma current Tokamak discharges in which a part of the current is driven by L.H.W. have been extensively studied on PETULA and this mode of operation has proven to be very efficient in stabilizing the sawtooth and M.H.D. activity

  17. The Tore Supra Lower Hybrid Test Bed : improvements and applications

    International Nuclear Information System (INIS)

    Delpech, L.; Achard, J.; Beaumont, B.

    2006-01-01

    Within the CIMES project framework in Tore Supra, a klystron TH2103C (3.7 GHz) is under development at THALES ELECTRON DEVICES. It differs from the previous klystrons used in Tore Supra generator mainly in that it has no modulating anode, the RF output power will reach 700 kW CW, by raising the High Voltage value to 76 kV and a beam current up to 23 A. The Tore Supra test bed is a dedicated facility used for high power tests on RF components or on RF transmitters. It has been improved to integrate the TH2103C klystron and a specific 100 kV solide state switch which control the beam current. Since April 2005, the integration of the first tube (without modulating anode) and the 100 kV switch has been completed in the Test Bed and has allowed the modifications and tests of the interfaces and security system for the devices. Improvements were also made on the cooling loop flow to dissipate a power of 1750 kW CW. With these devices, the RF power routinely available in the Lower Hybrid Test Bed is 400 kW CW. With the development of the TH2103C, detailed studies and tests on RF components which will be used up to 750 kW CW on match load or 700 kW on VSWR = 1.4, are necessary to evaluate their performances and thermal behaviour. The test a crucial component, the recombiner, which adds the RF powers coming from the two RF outputs of the TH2103C and inject the resulted power into one WR284 waveguide to a test load or to the plasma, was completed. Two tests have been performed : a thermal study with 400 kW during 1000 s, and RF pulsed tests on short cuts to increase the value of the electric field inside the component. The experiments and calculations (ANSYS and HFSS codes) validate the use of this device with the TH2103C. A module made with two different Beryllium Oxide RF windows, has been under test. The losses on each window are measured by calorimetric measurements and evaluated by computation with HFSS and ANSYS code. The results are compared. In this paper, the

  18. Adaptation of antenna profiles for control of MR guided hyperthermia (HT) in a hybrid MR-HT system

    International Nuclear Information System (INIS)

    Weihrauch, Mirko; Wust, Peter; Weiser, Martin; Nadobny, Jacek; Eisenhardt, Steffen; Budach, Volker; Gellermann, Johanna

    2007-01-01

    A combined numerical-experimental iterative procedure, based on the Gauss-Newton algorithm, has been developed for control of magnetic resonance (MR)-guided hyperthermia (HT) applications in a hybrid MR-HT system BSD 2000 3D-MRI. In this MR-HT system, composed of a 3-D HT applicator Sigma-Eye placed inside a tunnel-type MR tomograph Siemens MAGNETOM Symphony (1.5 T), the temperature rise due to the HT radiation can be measured on-line in three dimensions by use of the proton resonance frequency shift (PRFS) method. The basic idea of our iterative procedure is the improvement of the system's characterization by a step-by-step modification of the theoretical HT antenna profiles (electric fields radiated by single antennas). The adaptation of antenna profiles is efficient if the initial estimates are radiation fields calculated from a good a priori electromagnetic model. Throughout the iterative procedure, the calculated antenna fields (FDTD) are step-by-step modified by comparing the calculated and experimental data, the latter obtained using the PRFS method. The procedure has been experimentally tested on homogeneous and inhomogeneous phantoms. It is shown that only few comparison steps are necessary for obtaining a dramatic improvement of the general predictability and quality of the specific absorption rate (SAR) inside the MR-HT hybrid system

  19. Nonlinear Analysis and Preliminary Testing Results of a Hybrid Wing Body Center Section Test Article

    Science.gov (United States)

    Przekop, Adam; Jegley, Dawn C.; Rouse, Marshall; Lovejoy, Andrew E.; Wu, Hsi-Yung T.

    2015-01-01

    A large test article was recently designed, analyzed, fabricated, and successfully tested up to the representative design ultimate loads to demonstrate that stiffened composite panels with through-the-thickness reinforcement are a viable option for the next generation large transport category aircraft, including non-conventional configurations such as the hybrid wing body. This paper focuses on finite element analysis and test data correlation of the hybrid wing body center section test article under mechanical, pressure and combined load conditions. Good agreement between predictive nonlinear finite element analysis and test data is found. Results indicate that a geometrically nonlinear analysis is needed to accurately capture the behavior of the non-circular pressurized and highly-stressed structure when the design approach permits local buckling.

  20. Simulation and Test of a Fuel Cell Hybrid Golf Cart

    Directory of Open Access Journals (Sweden)

    Jingming Liang

    2014-01-01

    Full Text Available This paper establishes the simulation model of fuel cell hybrid golf cart (FCHGC, which applies the non-GUI mode of the Advanced Vehicle Simulator (ADVISOR and the genetic algorithm (GA to optimize it. Simulation of the objective function is composed of fuel consumption and vehicle dynamic performance; the variables are the fuel cell stack power sizes and the battery numbers. By means of simulation, the optimal parameters of vehicle power unit, fuel cell stack, and battery pack are worked out. On this basis, GUI mode of ADVISOR is used to select the rated power of vehicle motor. In line with simulation parameters, an electrical golf cart is refitted by adding a 2 kW hydrogen air proton exchange membrane fuel cell (PEMFC stack system and test the FCHGC. The result shows that the simulation data is effective but it needs improving compared with that of the real cart test.

  1. Adaptive Hybrid Control of Vehicle Semiactive Suspension Based on Road Profile Estimation

    Directory of Open Access Journals (Sweden)

    Yechen Qin

    2015-01-01

    Full Text Available A new road estimation based suspension hybrid control strategy is proposed. Its aim is to adaptively change control gains to improve both ride comfort and road handling with the constraint of rattle space. To achieve this, analytical expressions for ride comfort, road handling, and rattle space with respect to road input are derived based on the hybrid control, and the problem is transformed into a MOOP (Multiobjective Optimization Problem and has been solved by NSGA-II (Nondominated Sorting Genetic Algorithm-II. A new road estimation and classification method, which is based on ANFIS (Adaptive Neurofuzzy Inference System and wavelet transforms, is then presented as a means of detecting the road profile level, and a Kalman filter is designed for observing unknown states. The results of simulations conducted with random road excitation show that the efficiency of the proposed control strategy compares favourably to that of a passive system.

  2. Hybrid Lentivirus-transposon Vectors With a Random Integration Profile in Human Cells

    DEFF Research Database (Denmark)

    Staunstrup, Nicklas H; Moldt, Brian; Mátés, Lajos

    2009-01-01

    Gene delivery by human immunodeficiency virus type 1 (HIV-1)-based lentiviral vectors (LVs) is efficient, but genomic integration of the viral DNA is strongly biased toward transcriptionally active loci resulting in an increased risk of insertional mutagenesis in gene therapy protocols. Nonviral...... Sleeping Beauty (SB) transposon vectors have a significantly safer insertion profile, but efficient delivery into relevant cell/tissue types is a limitation. In an attempt to combine the favorable features of the two vector systems we established a novel hybrid vector technology based on SB transposase......-mediated insertion of lentiviral DNA circles generated during transduction of target cells with integrase (IN)-defective LVs (IDLVs). By construction of a lentivirus-transposon hybrid vector allowing transposition exclusively from circular viral DNA substrates, we demonstrate that SB transposase added in trans...

  3. Tailoring double Fano profiles with plasmon-assisted quantum interference in hybrid exciton-plasmon system

    International Nuclear Information System (INIS)

    Zhao, Dongxing; Wu, Jiarui; Gu, Ying; Gong, Qihuang

    2014-01-01

    We propose tailoring of the double Fano profiles via plasmon-assisted quantum interference in a hybrid exciton-plasmon system. Tailoring is performed by the interference between two exciton channels interacting with a common localized surface plasmon. Using an applied field of low intensity, the absorption spectrum of the hybrid system reveals a double Fano lineshape with four peaks. For relatively large field intensity, a broad flat window in the absorption spectrum appears which results from the destructive interference between excitons. Because of strong constructive interference, this window vanishes as intensity is further increased. We have designed a nanometer bandpass optical filter for visible light based on tailoring of the optical spectrum. This study provides a platform for quantum interference that may have potential applications in ultracompact tunable quantum devices.

  4. Hybrid testing of lumbar CHARITE discs versus fusions.

    Science.gov (United States)

    Panjabi, Manohar; Malcolmson, George; Teng, Edward; Tominaga, Yasuhiro; Henderson, Gweneth; Serhan, Hassan

    2007-04-20

    An in vitro human cadaveric biomechanical study. To quantify effects on operated and other levels, including adjacent levels, due to CHARITE disc implantations versus simulated fusions, using follower load and the new hybrid test method in flexion-extension and bilateral torsion. Spinal fusion has been associated with long-term accelerated degeneration at adjacent levels. As opposed to the fusion, artificial discs are designed to preserve motion and diminish the adjacent-level effects. Five fresh human cadaveric lumbar specimens (T12-S1) underwent multidirectional testing in flexion-extension and bilateral torsion with 400 N follower load. Intact specimen total ranges of motion were determined with +/-10 Nm unconstrained pure moments. The intact range of motion was used as input for the hybrid tests of 5 constructs: 1) CHARITE disc at L5-S1; 2) fusion at L5-S1; 3) CHARITE discs at L4-L5 and L5-S1; 4) CHARITE disc at L4-L5 and fusion at L5-S1; and 5) 2-level fusion at L4-L5-S1. Using repeated-measures single factor analysis of variance and Bonferroni statistical tests (P < 0.05), intervertebral motion redistribution of each construct was compared with the intact. In flexion-extension, 1-level CHARITE disc preserved motion at the operated and other levels, while 2-level CHARITE showed some amount of other-level effects. In contrast, 1- and 2-level fusions increased other-level motions (average, 21.0% and 61.9%, respectively). In torsion, both 1- and 2-level discs preserved motions at all levels. The 2-level simulated fusion increased motions at proximal levels (22.9%), while the 1-level fusion produced no significant changes. In general, CHARITE discs preserved operated- and other-level motions. Fusion simulations affected motion redistribution at other levels, including adjacent levels.

  5. Design, test and model of a hybrid magnetostrictive hydraulic actuator

    International Nuclear Information System (INIS)

    Chaudhuri, Anirban; Yoo, Jin-Hyeong; Wereley, Norman M

    2009-01-01

    The basic operation of hybrid hydraulic actuators involves high frequency bi-directional operation of an active material that is converted to uni-directional motion of hydraulic fluid using valves. A hybrid actuator was developed using magnetostrictive material Terfenol-D as the driving element and hydraulic oil as the working fluid. Two different lengths of Terfenol-D rod, 51 and 102 mm, with the same diameter, 12.7 mm, were used. Tests with no load and with load were carried out to measure the performance for uni-directional motion of the output piston at different pumping frequencies. The maximum no-load flow rates were 24.8 cm 3 s −1 and 22.7 cm 3 s −1 with the 51 mm and 102 mm long rods respectively, and the peaks were noted around 325 Hz pumping frequency. The blocked force of the actuator was close to 89 N in both cases. A key observation was that, at these high pumping frequencies, the inertial effects of the fluid mass dominate over the viscous effects and the problem becomes unsteady in nature. In this study, we also develop a mathematical model of the hydraulic hybrid actuator in the time domain to show the basic operational principle under varying conditions and to capture phenomena affecting system performance. Governing equations for the pumping piston and output shaft were obtained from force equilibrium considerations, while compressibility of the working fluid was taken into account by incorporating the bulk modulus. Fluid inertia was represented by a lumped parameter approach to the transmission line model, giving rise to strongly coupled ordinary differential equations. The model was then used to calculate the no-load velocities of the actuator at different pumping frequencies and simulation results were compared with experimental data for model validation

  6. Deducing hybrid performance from parental metabolic profiles of young primary roots of maize by using a multivariate diallel approach.

    Directory of Open Access Journals (Sweden)

    Kristen Feher

    Full Text Available Heterosis, the greater vigor of hybrids compared to their parents, has been exploited in maize breeding for more than 100 years to produce ever better performing elite hybrids of increased yield. Despite extensive research, the underlying mechanisms shaping the extent of heterosis are not well understood, rendering the process of selecting an optimal set of parental lines tedious. This study is based on a dataset consisting of 112 metabolite levels in young roots of four parental maize inbred lines and their corresponding twelve hybrids, along with the roots' biomass as a heterotic trait. Because the parental biomass is a poor predictor for hybrid biomass, we established a model framework to deduce the biomass of the hybrid from metabolite profiles of its parental lines. In the proposed framework, the hybrid metabolite levels are expressed relative to the parental levels by incorporating the standard concept of additivity/dominance, which we name the Combined Relative Level (CRL. Our modeling strategy includes a feature selection step on the parental levels which are demonstrated to be predictive of CRL across many hybrid metabolites. We demonstrate that these selected parental metabolites are further predictive of hybrid biomass. Our approach directly employs the diallel structure in a multivariate fashion, whereby we attempt to not only predict macroscopic phenotype (biomass, but also molecular phenotype (metabolite profiles. Therefore, our study provides the first steps for further investigations of the genetic determinants to metabolism and, ultimately, growth. Finally, our success on the small-scale experiments implies a valid strategy for large-scale experiments, where parental metabolite profiles may be used together with profiles of selected hybrids as a training set to predict biomass of all possible hybrids.

  7. Adjoint optimization scheme for lower hybrid current rampup and profile control in Tokamak

    International Nuclear Information System (INIS)

    Litaudon, X.; Moreau, D.; Bizarro, J.P.; Hoang, G.T.; Kupfer, K.; Peysson, Y.; Shkarofsky, I.P.; Bonoli, P.

    1992-12-01

    The purpose of this work is to take into account and study the effect of the electric field profiles on the Lower Hybrid (LH) current drive efficiency during transient phases such as rampup. As a complement to the full ray-tracing / Fokker Planck studies, and for the purpose of optimization studies, we developed a simplified 1-D model based on the adjoint Karney-Fisch numerical results. This approach allows us to estimate the LH power deposition profile which would be required for ramping the current with prescribed rate, total current density profile (q-profile) and surface loop voltage. For rampup optimization studies, we can therefore scan the whole parameter space and eliminate a posteriori those scenarios which correspond to unrealistic deposition profiles. We thus obtain the time evolution of the LH power, minor radius of the plasma, volt-second consumption and total energy dissipated. Optimization can thus be performed with respect to any of those criteria. This scheme is illustrated by some numerical simulations performed with TORE-SUPRA and NET/ITER parameters. We conclude with a derivation of a simple and general scaling law for the flux consumption during the rampup phase

  8. Power deposition profile during lower hybrid current drive in Tore Supra

    International Nuclear Information System (INIS)

    Pecquet, A.L.; Moreau, D.; Fall, T.; Lasalle, J.; Lecoustey, P.; Mattioli, M.; Peysson, Y.; Auge, N.; Rodriguez, L.; Talvard, M.; Hubbard, A.; Moret, J.M.

    1991-01-01

    Lower hybrid current drive (LHCD) experiments have been performed in Tore Supra in various density regimes. The total power coupled to the plasma reached 4MW and a strong electron heating has been observed. To investigate the power deposition mechanism on the electrons, r.f power modulation experiments have been performed. These experiments allow us to estimate the power deposition profiles on both thermal and non-thermal electrons and also to study their respective time responses. From these studies it is possible to deduce a thermal heating scenario which agrees with the experimental results

  9. Real life testing of a Hybrid PEM Fuel Cell Bus

    Science.gov (United States)

    Folkesson, Anders; Andersson, Christian; Alvfors, Per; Alaküla, Mats; Overgaard, Lars

    Fuel cells produce low quantities of local emissions, if any, and are therefore one of the most promising alternatives to internal combustion engines as the main power source in future vehicles. It is likely that urban buses will be among the first commercial applications for fuel cells in vehicles. This is due to the fact that urban buses are highly visible for the public, they contribute significantly to air pollution in urban areas, they have small limitations in weight and volume and fuelling is handled via a centralised infrastructure. Results and experiences from real life measurements of energy flows in a Scania Hybrid PEM Fuel Cell Concept Bus are presented in this paper. The tests consist of measurements during several standard duty cycles. The efficiency of the fuel cell system and of the complete vehicle are presented and discussed. The net efficiency of the fuel cell system was approximately 40% and the fuel consumption of the concept bus is between 42 and 48% lower compared to a standard Scania bus. Energy recovery by regenerative braking saves up 28% energy. Bus subsystems such as the pneumatic system for door opening, suspension and brakes, the hydraulic power steering, the 24 V grid, the water pump and the cooling fans consume approximately 7% of the energy in the fuel input or 17% of the net power output from the fuel cell system. The bus was built by a number of companies in a project partly financed by the European Commission's Joule programme. The comprehensive testing is partly financed by the Swedish programme "Den Gröna Bilen" (The Green Car). A 50 kW el fuel cell system is the power source and a high voltage battery pack works as an energy buffer and power booster. The fuel, compressed hydrogen, is stored in two high-pressure stainless steel vessels mounted on the roof of the bus. The bus has a series hybrid electric driveline with wheel hub motors with a maximum power of 100 kW. Hybrid Fuel Cell Buses have a big potential, but there are

  10. Seed oil triglyceride profiling of thirty-two hybrid grape varieties.

    Science.gov (United States)

    De Marchi, Fabiola; Seraglia, Roberta; Molin, Laura; Traldi, Pietro; De Rosso, Mirko; Panighel, Annarita; Dalla Vedova, Antonio; Gardiman, Massimo; Giust, Mirella; Flamini, Riccardo

    2012-09-01

    Triglyceride profile of seed oil samples from 32 hybrid grape varieties not studied before was investigated. A new method for the analysis of triacylglycerols (TAGs) has been developed based on the direct infusion in the electrospray ionization (ESI) source and employing tetrahydrofuran/methanol/water (85:10:5 v|v|v) as solvent; the formation of [M + Na](+) ions in high yield has been observed. TAGs were identified by ESI-tandem mass spectrometry analysis, and the matrix-assisted-laser-desorption-ionization and time-of-flight profile of samples was determined. Six were the principal TAGs identified in seed oil: trilinolein (LLL) was the most abundant (43%), followed by dilinoleoyl-oleoylglycerol (LOL, 23%), and dilinoleoyl-palmitoylglycerol (LPL, 15%). Compounds present in lower concentration were LSL and LOO (11%), LOP (6%), and LSP (2%). Compared with seed oils produced from V. Vinifera grapes, some significant differences in the relative abundances of TAGs were found, in particular hybrid grape seed oils showed higher LOL and lower LPL content, respectively. Among the samples studied, a particularly high content of LLL (rich in unsaturated fatty acids) was found in seed oils from two red varieties. Copyright © 2012 John Wiley & Sons, Ltd.

  11. Corrosion Testing of Hybrid Welded Stainless Steel Pot

    DEFF Research Database (Denmark)

    Sondrup, Lars de Caldas; Bagger, Claus; Olsen, Flemming Ove

    2004-01-01

    Investigation of the use of hybrid welding by preparation of tailored blanks for the manufacturing of a deep drawn pot.......Investigation of the use of hybrid welding by preparation of tailored blanks for the manufacturing of a deep drawn pot....

  12. Observations on a hybrid poplar test planting in West Virginia

    Science.gov (United States)

    Arthur R. Eschner

    1960-01-01

    Hybrid poplars, crosses between European and American Aigeiros poplars, have been grown in Europe for about 200 years. The rapid growth and high productivity of some of these hybrids on sites to which they are adapted has stimulated interest in poplar growing in this country. And demand for these poplars is developing in many parts of the United States.

  13. Sled Tests Using the Hybrid III Rail Safety ATD and Workstation Tables for Passenger Trains

    Science.gov (United States)

    2017-08-01

    The Hybrid III Rail Safety (H3-RS) anthropomorphic test device (ATD) is a crash test dummy developed in the United Kingdom to evaluate abdomen and lower thorax injuries that occur when passengers impact workstation tables during train accidents. The ...

  14. Genomic profiling of oral squamous cell carcinoma by array-based comparative genomic hybridization.

    Directory of Open Access Journals (Sweden)

    Shunichi Yoshioka

    Full Text Available We designed a study to investigate genetic relationships between primary tumors of oral squamous cell carcinoma (OSCC and their lymph node metastases, and to identify genomic copy number aberrations (CNAs related to lymph node metastasis. For this purpose, we collected a total of 42 tumor samples from 25 patients and analyzed their genomic profiles by array-based comparative genomic hybridization. We then compared the genetic profiles of metastatic primary tumors (MPTs with their paired lymph node metastases (LNMs, and also those of LNMs with non-metastatic primary tumors (NMPTs. Firstly, we found that although there were some distinctive differences in the patterns of genomic profiles between MPTs and their paired LNMs, the paired samples shared similar genomic aberration patterns in each case. Unsupervised hierarchical clustering analysis grouped together 12 of the 15 MPT-LNM pairs. Furthermore, similarity scores between paired samples were significantly higher than those between non-paired samples. These results suggested that MPTs and their paired LNMs are composed predominantly of genetically clonal tumor cells, while minor populations with different CNAs may also exist in metastatic OSCCs. Secondly, to identify CNAs related to lymph node metastasis, we compared CNAs between grouped samples of MPTs and LNMs, but were unable to find any CNAs that were more common in LNMs. Finally, we hypothesized that subpopulations carrying metastasis-related CNAs might be present in both the MPT and LNM. Accordingly, we compared CNAs between NMPTs and LNMs, and found that gains of 7p, 8q and 17q were more common in the latter than in the former, suggesting that these CNAs may be involved in lymph node metastasis of OSCC. In conclusion, our data suggest that in OSCCs showing metastasis, the primary and metastatic tumors share similar genomic profiles, and that cells in the primary tumor may tend to metastasize after acquiring metastasis-associated CNAs.

  15. EFFECTS OF ACOUSTIC STIMULATION ON BIOPHYSICAL PROFILE TESTING TIME

    Directory of Open Access Journals (Sweden)

    M. Pourissa

    2008-04-01

    Full Text Available Biophysical profile (BPP test is the most commonly used antenatal test of fetal well-being. Purpose of this study is determining the influence of acoustic stimulation (AS on BPP testing time. About 55 pregnant women at 35 to 42 weeks who referred to department of Obstetric & Gynecology at university of medical sciences, Tabriz, Iran, were selected randomly. We used abdominal ultrasound guidance to place buzzer like device with power of 110 dB at the skin surface of the maternal abdomen, close to the fetal head. BPP test performed and BPP mean testing time calculated before and after AS. Data compared and analyzed by paired t-test. The results showed that fetal AS reduces the overall mean testing time from 24 minutes to 5 minutes. This clinical application can be helpful in busy clinics when rapid assessment of fetal health is required.

  16. Control of the current density profile with lower hybrid current drive on PBX-M

    International Nuclear Information System (INIS)

    Bell, R.E.; Bernabei, S.; Chu, T.K.; Gettelfinger, G.; Greenough, N.; Hatcher, R.; Ignat, D.; Jardin, S.; Kaita, R.; Kaye, S.; Kozub, T.; Kugel, H.; LeBlanc, B.; Okabayashi, M.; Paul, S.; Sauthoff, N.; Sesnic, S.; Sun, Y.; Takahashi, H.; Tighe, W.; Valeo, E.; von Goeler, S.; Jones, S.; Kesner, J.; Luckhardt, S.; Paoletti, F.; Levinton, F.; Timini, F.

    1993-07-01

    Lower hybrid current drive (LHCD) is being explored as a means to control the current density profile on PBX-M with the goal of raising the central safety factor q(O) to values of 1.5-2 to facilitate access to a full-volume second stable regime. Initial experiments have been conducted with up to 400 kW of 4.6 GHz LH power in circular and indented plasmas with modest parameters. A tangential-viewing two-dimensional hard x-ray imaging diagnostic has been used to observe the bremsstrahlung emission from the suprathermal electrons generated during LHCD. Hollow hard x-ray images have indicated off-axis localization of the driven current. A serious obstacle to the control of the current density profile with LHCD is the concomitant generation of MHD activity, which can seriously degrade the confinement of suprathermal electrons. By combining neutral beam injection with LHCD, an MHD-free condition has been obtained where q(O) is raised above 1

  17. Profile control simulations and experiments on TCV: a controller test environment and results using a model-based predictive controller

    Science.gov (United States)

    Maljaars, E.; Felici, F.; Blanken, T. C.; Galperti, C.; Sauter, O.; de Baar, M. R.; Carpanese, F.; Goodman, T. P.; Kim, D.; Kim, S. H.; Kong, M.; Mavkov, B.; Merle, A.; Moret, J. M.; Nouailletas, R.; Scheffer, M.; Teplukhina, A. A.; Vu, N. M. T.; The EUROfusion MST1-team; The TCV-team

    2017-12-01

    The successful performance of a model predictive profile controller is demonstrated in simulations and experiments on the TCV tokamak, employing a profile controller test environment. Stable high-performance tokamak operation in hybrid and advanced plasma scenarios requires control over the safety factor profile (q-profile) and kinetic plasma parameters such as the plasma beta. This demands to establish reliable profile control routines in presently operational tokamaks. We present a model predictive profile controller that controls the q-profile and plasma beta using power requests to two clusters of gyrotrons and the plasma current request. The performance of the controller is analyzed in both simulation and TCV L-mode discharges where successful tracking of the estimated inverse q-profile as well as plasma beta is demonstrated under uncertain plasma conditions and the presence of disturbances. The controller exploits the knowledge of the time-varying actuator limits in the actuator input calculation itself such that fast transitions between targets are achieved without overshoot. A software environment is employed to prepare and test this and three other profile controllers in parallel in simulations and experiments on TCV. This set of tools includes the rapid plasma transport simulator RAPTOR and various algorithms to reconstruct the plasma equilibrium and plasma profiles by merging the available measurements with model-based predictions. In this work the estimated q-profile is merely based on RAPTOR model predictions due to the absence of internal current density measurements in TCV. These results encourage to further exploit model predictive profile control in experiments on TCV and other (future) tokamaks.

  18. Development and Testing of an UltraBattery-Equipped Honda Civic Hybrid

    Energy Technology Data Exchange (ETDEWEB)

    Sally (Xiaolei) Sun; Tyler Gray; Pattie Hovorka; Jeffrey Wishart; Donald Karner; James Francfort

    2012-08-01

    The UltraBattery Retrofit Project DP1.8 and Carbon Enriched Project C3, performed by ECOtality North America (ECOtality) and funded by the U.S. Department of Energy and the Advanced Lead Acid Battery Consortium (ALABC), are established to demonstrate the suitability of advanced lead battery technology in hybrid electrical vehicles (HEVs). A profile, termed the “Simulated Honda Civic HEV Profile” (SHCHEVP) has been developed in Project DP1.8 in order to provide reproducible laboratory evaluations of different battery types under real-world HEV conditions. The cycle is based on the Urban Dynamometer Driving Schedule and Highway Fuel Economy Test cycles and simulates operation of a battery pack in a Honda Civic HEV. One pass through the SHCHEVP takes 2,140 seconds and simulates 17.7 miles of driving. A complete nickel metal hydride (NiMH) battery pack was removed from a Honda Civic HEV and operated under SHCHEVP to validate the profile. The voltage behavior and energy balance of the battery during this operation was virtually the same as that displayed by the battery when in the Honda Civic operating on the dynamometer under the Urban Dynamometer Driving Schedule and Highway Fuel Economy Test cycles, thus confirming the efficacy of the simulated profile. An important objective of the project has been to benchmark the performance of the UltraBatteries manufactured by both Furukawa Battery Co., Ltd., Japan (Furakawa) and East Penn Manufacturing Co., Inc. (East Penn). Accordingly, UltraBattery packs from both Furakawa and East Penn have been characterized under a range of conditions. Resistance measurements and capacity tests at various rates show that both battery types are very similar in performance. Both technologies, as well as a standard lead-acid module (included for baseline data), were evaluated under a simple HEV screening test. Both Furakawa and East Penn UltraBattery packs operated for over 32,000 HEV cycles, with minimal loss in performance; whereas the

  19. Testing a hypothesis of unidirectional hybridization in plants: Observations on Sonneratia, Bruguiera and Ligularia

    Directory of Open Access Journals (Sweden)

    Wu Chung-I

    2008-05-01

    Full Text Available Abstract Background When natural hybridization occurs at sites where the hybridizing species differ in abundance, the pollen load delivered to the rare species should be predominantly from the common species. Previous authors have therefore proposed a hypothesis on the direction of hybridization: interspecific hybrids are more likely to have the female parent from the rare species and the male parent from the common species. We wish to test this hypothesis using data of plant hybridizations both from our own experimentation and from the literature. Results By examining the maternally inherited chloroplast DNA of 6 cases of F1 hybridization from four genera of plants, we infer unidirectional hybridization in most cases. In all 5 cases where the relative abundance of the parental species deviates from parity, however, the direction is predominantly in the direction opposite of the prediction based strictly on numerical abundance. Conclusion Our results show that the observed direction of hybridization is almost always opposite of the predicted direction based on the relative abundance of the hybridizing species. Several alternative hypotheses, including unidirectional postmating isolation and reinforcement of premating isolation, were discussed.

  20. Psychometric properties of the Plutchik's EPI test (Emotions Profile Index

    Directory of Open Access Journals (Sweden)

    Ana Trebovc

    2005-04-01

    Full Text Available Authors report a study on psychometric properties of Plutchik's test, called Emotions Profile Index (EPI. A new Slovene translation and adaptation of English version of the test, consisting of combinations (pairs of 12 words reflecting eight different emotional conditions, was prepared and compared to the old one. Both versions as well as the Big Five Questionnaire (BFQ were administered on the sample of 239 participants. Different statistical analyses were performed examining psychometric features of both versions of EPI. Discriminative power was tested by cluster analysis and analysis of frequency distributions, reliability was studied via internal consistency index and correlation between the two versions, and validity was examined by correlating PIE dimensions with BFQ dimensions and subdimensions, by comparing profiles of groups on both versions of EPI and BFQ and by fitting the theoretical model proposed by Plutchik to the data. Discriminative power of EPI seems to be affected by avoiding (not choosing the socially desirable expressions in the test, parallel reliability seems to be susceptible to the use of different words (expressions in the new version of EPI having the same meaning as words in the old version. Dimensions expected to reflect similar constructs in BFQ and EPI do not correlate satisfactory. Data gathered with EPI cannot be fully explained with the model proposed by Plutchik's theory.

  1. Hybrid Test Bed of Wind Electric Generator with Photovoltaic Panels

    OpenAIRE

    G.D.Anbarasi Jebaselvi; S.Paramasivam

    2014-01-01

    Driven by the increasing costs of power production and decreasing fossil fuel reserves with the addition of global environmental concerns, renewable energy is now becoming significant fraction of total electricity production in the world. Advancements in the field of wind electric generator technology and power electronics help to achieve rapid progress in hybrid power system which mainly involves wind, solar and diesel energy with a good battery back-up. Here the discussion brings about the ...

  2. Cross-reactivity profiles of hybrid capture II, cobas, and APTIMA human papillomavirus assays

    DEFF Research Database (Denmark)

    Preisler, Sarah Nørgaard; Rebolj, Matejka; Ejegod, Ditte Møller

    2016-01-01

    evaluated to what extent these can be explained by cross-reactivity, i.e. positive test results without evidence of high-risk HPV genotypes. The patterns of cross-reactivity have been thoroughly studied for hybrid capture II (HC2) but not yet for newer HPV assays although the manufacturers claimed...... no or limited frequency of cross-reactivity. In this independent study we evaluated the frequency of cross-reactivity for HC2, cobas, and APTIMA assays. Methods Consecutive routine cervical screening samples from 5022 Danish women, including 2859 from women attending primary screening, were tested...... with normal cytology and positive high-risk HPV test results were invited for repeated testing in 18 months. Results Cross-reactivity to low-risk genotypes was detected in 109 (2.2 %) out of 5022 samples on HC2, 62 (1.2 %) on cobas, and 35 (0.7 %) on APTIMA with only 10 of the samples cross-reacting on all 3...

  3. Integration profile and safety of an adenovirus hybrid-vector utilizing hyperactive sleeping beauty transposase for somatic integration.

    Directory of Open Access Journals (Sweden)

    Wenli Zhang

    Full Text Available We recently developed adenovirus/transposase hybrid-vectors utilizing the previously described hyperactive Sleeping Beauty (SB transposase HSB5 for somatic integration and we could show stabilized transgene expression in mice and a canine model for hemophilia B. However, the safety profile of these hybrid-vectors with respect to vector dose and genotoxicity remains to be investigated. Herein, we evaluated this hybrid-vector system in C57Bl/6 mice with escalating vector dose settings. We found that in all mice which received the hyperactive SB transposase, transgene expression levels were stabilized in a dose-dependent manner and that the highest vector dose was accompanied by fatalities in mice. To analyze potential genotoxic side-effects due to somatic integration into host chromosomes, we performed a genome-wide integration site analysis using linker-mediated PCR (LM-PCR and linear amplification-mediated PCR (LAM-PCR. Analysis of genomic DNA samples obtained from HSB5 treated female and male mice revealed a total of 1327 unique transposition events. Overall the chromosomal distribution pattern was close-to-random and we observed a random integration profile with respect to integration into gene and non-gene areas. Notably, when using the LM-PCR protocol, 27 extra-chromosomal integration events were identified, most likely caused by transposon excision and subsequent transposition into the delivered adenoviral vector genome. In total, this study provides a careful evaluation of the safety profile of adenovirus/Sleeping Beauty transposase hybrid-vectors. The obtained information will be useful when designing future preclinical studies utilizing hybrid-vectors in small and large animal models.

  4. Measurement of lower-hybrid-driven current profile by Abel inversion of electron-cyclotron wave transmission spectra

    International Nuclear Information System (INIS)

    Fidone, I.; Giruzzi, G.; Caron, X.; Meyer, R.L.

    1991-01-01

    A method for measuring the radial profile of the lower-hybrid-driven current in a low-density tokamak plasma using electron-cyclotron wave attenuation is discussed. This diagnostic scheme is reminiscent of the transmission interferometry approach, commonly used in tokamaks to measure the plasma density, but now the wave amplitude instead of the phase is measured. Wave attenuation of the ordinary mode at ω p much-lt ω c along vertical chords is measured; at these frequencies, the waves are absorbed by the superthermal tail sustained by lower-hybrid waves and the local wave absorption coefficient is proportional to the noninductive current density. The radial profile of this current is obtained from Abel inversion. An application to the Tore Supra tokamak is presented

  5. Genetic profiles of gastroesophageal cancer: combined analysis using expression array and tiling array--comparative genomic hybridization

    DEFF Research Database (Denmark)

    Isinger-Ekstrand, Anna; Johansson, Jan; Ohlsson, Mattias

    2010-01-01

    15, 13q34, and 12q13, whereas different profiles with gains at 5p15, 7p22, 2q35, and 13q34 characterized gastric cancers. CDK6 and EGFR were identified as putative target genes in cancers of the esophagus and the gastroesophageal junction, with upregulation in one quarter of the tumors. Gains......We aimed to characterize the genomic profiles of adenocarcinomas in the gastroesophageal junction in relation to cancers in the esophagus and the stomach. Profiles of gains/losses as well as gene expression profiles were obtained from 27 gastroesophageal adenocarcinomas by means of 32k high......-resolution array-based comparative genomic hybridization and 27k oligo gene expression arrays, and putative target genes were validated in an extended series. Adenocarcinomas in the distal esophagus and the gastroesophageal junction showed strong similarities with the most common gains at 20q13, 8q24, 1q21-23, 5p...

  6. Edge profiles and limiter tests in Extrap T2

    Science.gov (United States)

    Bergsåker, H.; Hedin, G.; Ilyinsky, L.; Larsson, D.; Möller, A.

    New edge profile measurements, including calorimetric measurements of the parallel heat flux, were made in Extrap T2. Test limiters of pure molybdenum and the TZM molybdenum alloy have been exposed in the edge plasma. The surface damage was studied, mainly by microscopy. Tungsten coated graphite probes were also exposed, and the surfaces were studied by microscopy, ion beam analysis and XPS. In this case cracking and mixing of carbon and tungsten at the interface was observed in the most heated areas, whereas carbide formation at the surface was seen in less heated areas. In these tests pure Mo generally fared better than TZM, and thin and cleaner coatings fared better than thicker and less clean.

  7. Simulation of lower hybrid current drive in enhanced reversed shear plasmas in the tokamak fusion test reactor using the lower hybrid simulation code

    International Nuclear Information System (INIS)

    Kaita, R.; Bernabei, S.; Budny, R.

    1996-01-01

    The Enhanced Reversed Shear (ERS) mode has already shown great potential for improving the performance of the Tokamak Fusion Test Reactor (TFTR) and other devices. Sustaining the ERS, however, remains an outstanding problem. Lower hybrid (LH) current drive is a possible method for modifying the current profile and controlling its time evolution. To predict its effectiveness in TFTR, the Lower Hybrid Simulation Code (LSC) model is used in the TRANSP code and the Tokamak Simulation Code (TSC). Among the results from the simulations are the following. (1) Single-pass absorption is expected in TFTR ERS plasmas. The simulations show that the LH current follows isotherms of the electron temperature. The ability to control the location of the minimum in the q profile (q min ) has been demonstrated by varying the phase velocity of the launched LH waves and observing the change in the damping location. (2) LH current drive can been used to sustain the q min location. The tendency of qmin to drift inward, as the inductive current diffuses during the formation phase of the reversed shear discharge, is prevented by the LH current driven at a fixed radial location. If this results in an expanded plasma volume with improved confinement as high power neutral beam injection is applied, the high bootstrap currents induced during this phase can then maintain the larger qmin radius. (3) There should be no LH wave damping on energetic beam particles. The values of perpendicular index of refraction in the calculations never exceed about 20, while ions at TFR injection energies are resonant with waves having values closer to 100. Other issues being addressed in the study include the LH current drive efficiency in the presence of high bootstrap currents, and the effect of fast electron diffusion on LH current localization

  8. Testing the 'hybrid susceptibility' and 'phenological sink' hypotheses using the P. balsamifera - P. deltoides hybrid zone and septoria leaf spot [Septoria musiva].

    Science.gov (United States)

    LeBoldus, Jared M; Isabel, Nathalie; Floate, Kevin D; Blenis, Peter; Thomas, Barb R

    2013-01-01

    Hybrid genotypes that arise between plant species frequently have increased susceptibility to arthropod pests and fungal pathogens. This pattern has been attributed to the breakdown of plant defenses ('Hybrid susceptibility' hypothesis) and (or) to extended periods of susceptibility attributed to plant phenologies in zones of species overlap and (or) hybridization ('phenological sink' hypothesis). We examined these hypotheses by assessing the susceptibility of parental and hybrid Populus host genotypes to a leaf spot disease caused by the fungal pathogen Septoria musiva. For this purpose, 214 genotypes were obtained from morphologically pure zones of P. balsamifera and P. deltoides, and from an intervening zone of overlap and hybridization on the drainage of the Red Deer River, Alberta, Canada. Genotypes were identified as P. balsamifera, P. deltoides, or hybrid using a suite of 27 species-specific SNP markers. Initially the genetic structure of the hybrid zone was characterized with 27.7% of trees classified as admixed individuals. To test the hybrid susceptibility hypothesis, a subset of 52 genotypes was inoculated with four isolates of S. musiva. Levels of susceptibility were P. balsamifera > F1 hybrid > P. deltoides. A further 53 genotypes were grown in a common garden to assess the effect of genotype on variation in leaf phenology. Leaf phenology was more variable within the category of hybrid genotypes than within categories of either parental species. Leaf phenology was also more variable for the category of trees originating in the hybrid (P. balsamifera - P. deltoides [hybrid and parental genotypes combined]) zone than in adjacent pure zones of the parental species. The results from the inoculation experiment support the hybrid intermediacy hypothesis. The results from the common garden experiment support the 'phenological sink' hypothesis. These findings have greatly increased our understanding of the epidemiology and ecology of fungal pathogens in plant

  9. Testing the 'hybrid susceptibility' and 'phenological sink' hypotheses using the P. balsamifera - P. deltoides hybrid zone and septoria leaf spot [Septoria musiva].

    Directory of Open Access Journals (Sweden)

    Jared M LeBoldus

    Full Text Available Hybrid genotypes that arise between plant species frequently have increased susceptibility to arthropod pests and fungal pathogens. This pattern has been attributed to the breakdown of plant defenses ('Hybrid susceptibility' hypothesis and (or to extended periods of susceptibility attributed to plant phenologies in zones of species overlap and (or hybridization ('phenological sink' hypothesis. We examined these hypotheses by assessing the susceptibility of parental and hybrid Populus host genotypes to a leaf spot disease caused by the fungal pathogen Septoria musiva. For this purpose, 214 genotypes were obtained from morphologically pure zones of P. balsamifera and P. deltoides, and from an intervening zone of overlap and hybridization on the drainage of the Red Deer River, Alberta, Canada. Genotypes were identified as P. balsamifera, P. deltoides, or hybrid using a suite of 27 species-specific SNP markers. Initially the genetic structure of the hybrid zone was characterized with 27.7% of trees classified as admixed individuals. To test the hybrid susceptibility hypothesis, a subset of 52 genotypes was inoculated with four isolates of S. musiva. Levels of susceptibility were P. balsamifera > F1 hybrid > P. deltoides. A further 53 genotypes were grown in a common garden to assess the effect of genotype on variation in leaf phenology. Leaf phenology was more variable within the category of hybrid genotypes than within categories of either parental species. Leaf phenology was also more variable for the category of trees originating in the hybrid (P. balsamifera - P. deltoides [hybrid and parental genotypes combined] zone than in adjacent pure zones of the parental species. The results from the inoculation experiment support the hybrid intermediacy hypothesis. The results from the common garden experiment support the 'phenological sink' hypothesis. These findings have greatly increased our understanding of the epidemiology and ecology of fungal

  10. Powertrain instrumentation and test systems development, hybridization, electrification

    CERN Document Server

    Paulweber, Michael

    2016-01-01

    The book deals with the increasingly complex test systems for powertrain components and systems giving an overview of the diverse types of test beds for all components of an advanced powertrain focusing on specific topics such as instrumentation, control, simulation, hardware-in-the-loop, automation or test facility management. This book is intended for powertrain (component) development engineers, test bed planners, test bed operators and beginners.

  11. Transcriptome profiling of mice testes following low dose irradiation

    DEFF Research Database (Denmark)

    Belling, Kirstine C.; Tanaka, Masami; Dalgaard, Marlene Danner

    2013-01-01

    ABSTRACT: BACKGROUND: Radiotherapy is used routinely to treat testicular cancer. Testicular cells vary in radio-sensitivity and the aim of this study was to investigate cellular and molecular changes caused by low dose irradiation of mice testis and to identify transcripts from different cell types...... in the adult testis. METHODS: Transcriptome profiling was performed on total RNA from testes sampled at various time points (n = 17) after 1 Gy of irradiation. Transcripts displaying large overall expression changes during the time series, but small expression changes between neighbouring time points were...... selected for further analysis. These transcripts were separated into clusters and their cellular origin was determined. Immunohistochemistry and in silico quantification was further used to study cellular changes post-irradiation (pi). RESULTS: We identified a subset of transcripts (n = 988) where changes...

  12. READINESS PROFILE OF JUNIOR CYCLISTS DETERMINED BY LEIPZIG TEST

    Directory of Open Access Journals (Sweden)

    Jovan Zlatković

    2010-09-01

    Full Text Available The aim of this paper was to define the readiness profile of junior cyclists determined by the Leipzig test. The second aim was to find out if there were differences in functional performance among cyclists in different disciplines, such as: road cyclists, mountain bikers and sprinters. All cyclists (n=18 were tested with Leipzig test protocol on a bicycle ergometer by increasing the load by 40W per minute, pedalling cadence 90- 100rev/min. The hearth rate was measured at the beginning and at the end of the test, together with the maximal oxygen uptake (VO2max. The results have shown that the maximal oxygen uptake among national junior cyclists in all disciplines was VO2max 56.42±5.82 ml•min-1kg-1, among mountain biking cyclist VO2max was 61.43±4.94, sprinters VO2max 56.78±3.33 and for cross-country cyclists VO2max 53.37±7.82. The statistical analysis of the functional performance results has snown that between subsamples of cyclists there were no significant differences on general level. However, the partial analysis has snown that there is a statistically significant difference between the groups in the hart rate values on an anaerobic threshold (F value 4.547, p=0.032. In conclusion, the tested cyclists were prepared using general training methods even if they had competitions in different disciplines. Therefore, the level of readiness shows that the training process for young cyclists which is used in Serbia is not specific for the competition level and discipline.

  13. In ovo delivery of Newcastle disease virus conjugated hybrid calcium phosphate nanoparticle and to study the cytokine profile induction

    International Nuclear Information System (INIS)

    Viswanathan, Kaliyaperumal; Rathish, P.; Gopinath, V.P.; Janice, R.; Dhinakar Raj, G.

    2014-01-01

    In this report, the hybrid calcium phosphate (CaP) nanoparticles were synthesized and functionalized with Newcastle disease virus (NDV). These nanoparticles were synthesized by a combination of co-precipitation and polymerization process and functionalized with amino propyl triethoxy silane before coupling to NDV. The 5-dimethylthiazol-2-yl-2, 5-diphenyltetrazolium bromide (MTT) assay of chicken spleen cells incubated with these nanoparticles indicated that, these particles did not exert any significant cytotoxicity. The effects of hybrid CaP nanoparticles on cell cycle were assayed using a flow cytometer. The results demonstrated that the cell viability and proliferation capacity of spleen cells were not affected by hybrid CaP nanoparticles compared with their control cells. The hybrid CaP nanoparticles were characterized by scanning/transmission electron microscopy (SEM/TEM); Fourier transformed infrared spectroscopy (FTIR), X-ray diffraction patterns (XRD), Raman spectroscopy and energy-dispersive X-ray spectroscopy (EDX). These methods revealed that NDV was successfully conjugated on nanoparticles. The ability of the hybrid CaP nanoparticles to induce different cytokine mRNAs in the spleen cells of 18-day old embryonated chicken eggs (ECEs) was studied by quantitative real time polymerase chain reaction (qRT-PCR). NDV conjugated particles induced a high expression of Th1 cytokines such as interferon (IFN)-α, tumor necrosis factor (TNF)-α of and Th2 cytokines, interleukin (IL) 6 and IL-10. Uncoupled NDV induced only Th1 cytokines, IFN-α, INF-γ and TNF-α. The hybrid particles alone did not induce any cytokines. This confirmed that nanoparticle coupling could induce differential cytokine profiles and hence can be used as an alternate strategy to direct favorable immune responses in animals or chickens using appropriate vaccination carrier. - Highlights: • NDV conjugated hybrid CaP NP induced differential cytokine profiles in embryonated chicken eggs.

  14. In ovo delivery of Newcastle disease virus conjugated hybrid calcium phosphate nanoparticle and to study the cytokine profile induction

    Energy Technology Data Exchange (ETDEWEB)

    Viswanathan, Kaliyaperumal [Translational Research Platform for Veterinary Biologicals (TRPVB), Tamil Nadu Veterinary and Animal Sciences University, Chennai 600 051, Tamil Nadu (India); Rathish, P.; Gopinath, V.P.; Janice, R. [Department of Animal Biotechnology, Madras Veterinary College, Tamil Nadu Veterinary and Animal Sciences University, Chennai 600 007 (India); Dhinakar Raj, G., E-mail: dhinakarrajg@tanuvas.org.in [Department of Animal Biotechnology, Madras Veterinary College, Tamil Nadu Veterinary and Animal Sciences University, Chennai 600 007 (India); Translational Research Platform for Veterinary Biologicals (TRPVB), Tamil Nadu Veterinary and Animal Sciences University, Chennai 600 051, Tamil Nadu (India)

    2014-12-01

    In this report, the hybrid calcium phosphate (CaP) nanoparticles were synthesized and functionalized with Newcastle disease virus (NDV). These nanoparticles were synthesized by a combination of co-precipitation and polymerization process and functionalized with amino propyl triethoxy silane before coupling to NDV. The 5-dimethylthiazol-2-yl-2, 5-diphenyltetrazolium bromide (MTT) assay of chicken spleen cells incubated with these nanoparticles indicated that, these particles did not exert any significant cytotoxicity. The effects of hybrid CaP nanoparticles on cell cycle were assayed using a flow cytometer. The results demonstrated that the cell viability and proliferation capacity of spleen cells were not affected by hybrid CaP nanoparticles compared with their control cells. The hybrid CaP nanoparticles were characterized by scanning/transmission electron microscopy (SEM/TEM); Fourier transformed infrared spectroscopy (FTIR), X-ray diffraction patterns (XRD), Raman spectroscopy and energy-dispersive X-ray spectroscopy (EDX). These methods revealed that NDV was successfully conjugated on nanoparticles. The ability of the hybrid CaP nanoparticles to induce different cytokine mRNAs in the spleen cells of 18-day old embryonated chicken eggs (ECEs) was studied by quantitative real time polymerase chain reaction (qRT-PCR). NDV conjugated particles induced a high expression of Th1 cytokines such as interferon (IFN)-α, tumor necrosis factor (TNF)-α of and Th2 cytokines, interleukin (IL) 6 and IL-10. Uncoupled NDV induced only Th1 cytokines, IFN-α, INF-γ and TNF-α. The hybrid particles alone did not induce any cytokines. This confirmed that nanoparticle coupling could induce differential cytokine profiles and hence can be used as an alternate strategy to direct favorable immune responses in animals or chickens using appropriate vaccination carrier. - Highlights: • NDV conjugated hybrid CaP NP induced differential cytokine profiles in embryonated chicken eggs.

  15. Comparison of Fluorescence In Situ Hybridization and Chromogenic In Situ Hybridization for Low and High Throughput HER2 Genetic Testing

    Science.gov (United States)

    Poulsen, Tim S.; Espersen, Maiken L. M.; Kofoed, Vibeke; Dabetic, Tanja; Høgdall, Estrid; Balslev, Eva

    2013-01-01

    The purpose was to evaluate and compare 5 different HER2 genetic assays with different characteristics that could affect the performance to analyze the human epidermal growth factor 2 (HER2) gene copy number under low and high throughput conditions. The study included 108 tissue samples from breast cancer patients with HER2 immunohistochemistry (IHC) results scored as 0/1+, 2+, and 3+. HER2 genetic status was analysed using chromogenic in situ hybridization (CISH) and fluorescence in situ hybridization (FISH). Scoring results were documented through digital image analysis. The cancer region of interest was identified from a serial H&E stained slide following tissue cores were transferred to a tissue microarrays (TMA). When using TMA in a routine flow, all patients will be tested for HER2 status with IHC followed by CISH or FISH, thereby providing individual HER2 results. In conclusion, our results show that the differences between the HER2 genetic assays do not have an effect on the analytic performance and the CISH technology is superior to high throughput HER2 genetic testing due to scanning speed, while the IQ-FISH may still be a choice for fast low throughput HER2 genetic testing. PMID:24383005

  16. A compact CMA spectrometer with axially integrated hybrid electron-ion gun for ISS, AES and sputter depth profile analysis

    International Nuclear Information System (INIS)

    Gisler, E.; Bas, E.B.

    1986-01-01

    Until now, the combined application of electrons and ions in surface analysis required two separate sources for electrons and ions with different incidence angles. The newly developed hybrid electron-ion gun, however, allows bombardment of the same sample area both with noble gas ions and with electrons coming from the same direction. By integrating such a hybrid gun axially in a cylindrical mirror energy analyser (CMA) a sensitive compact single flange spectrometer obtains for ion scattering spectroscopy (ISS), Auger electron spectroscopy (AES), and sputtering all within normal beam incidence. This concept makes accurate beam centering very easy. Additionally, the bombardment from the same direction both for sputtering and for surface analysis brings advantages in depth profiling. The scattering angle for ISS has a constant value of about 138 0 . The hybrid gun delivers typically an electron beam current of -20μA at 3keV for AES, and an ion beam current of +40 nA and +1.2μA at 2 keV for ISS and sputtering respectively. The switching time between ISS, AES, and sputtering mode is about 0.1 s. So this system is best suited for automatically controlled depth profile analysis. The design and operation of this new system will be described and some applications will be discussed. (author)

  17. Lipid profiles of blood serum and fatty acid composition of meat of hybrid duck fed diet supplemented with Noni (Morinda citrifolia fruit meal

    Directory of Open Access Journals (Sweden)

    David Kurniawan

    2015-09-01

    Full Text Available Noni fruit is a medicinal plant with biological activity like antioxidant that could potentially be used as a feed additive in poultry. This research investigated the effect of noni fruit powder as feed additive on lipid profiles of blood and meat fatty acid compositions of meat of hybrid duck. One hundred twenty 2-week-old hybrid ducks crossing between Peking and Khaki Campbell duck were subjected. They were randomly allotted to 24 experimental units. Each experimental unit was 70x80x40 cm in size and it was used for 5 ducks up to they reached 56 days of age. Each unit was equipped with waterer and feeder. The ducks were raised on litter-type floor. The basal experimental diet was formulated according to the standards of National Research Council (1994. The method used for this study was experimental with 4 different treatments in 6 replications. The treatments were as follow: P0: basal feed without supplementation of noni fruit powder as control; P1: basal feed + 1 % noni fruit powder; P2: basal feed + 2 % noni fruit powder; P3: basal feed + 3 % noni fruit powder. Data were analyzed by one-way of Completely Randomized Design ANOVA and if there was significant effect followed by Duncan’s Multiple Range Test. Result showed that using noni fruit powder as feed additive had no significant effect (P>0.05 on lipid profiles of blood and fatty acid composition of meat.

  18. Design and RF Test of Broadband Coaxial Hybrid Splitter for ITER ICRF System

    Energy Technology Data Exchange (ETDEWEB)

    Kim, H. J.; Wang, S. J.; Park, B. H.; Yang, H. L.; Kwak, J. G. [National Fusion Research Institute, Daejeon (Korea, Republic of); Choi, J. J. [Kwangwoon Univ., Seoul (Korea, Republic of)

    2013-10-15

    The ICRF system of the ITER is required to couple 20 MW to the plasma in the 40∼55 MHz frequency band for RF heating and current drive operation. The corresponding matching system of ICRF antenna must be load-resilient for a wide range of antenna load variations due to mode transitions or edge localized modes. Indeed the use of hybrid splitters ensures that no reflections occur at the generator when the reflections on the adjacent lines are equal both in magnitude and in phase, in which case all reflected power will not be seen by the generators and will be returned to the dummy loads. Most 3 dB coaxial hybrid circuits installed and implemented on the ICRF system is single section coupler providing best performance at the design frequency with narrow bandwidth. The bandwidth of such a single-section 3 dB hybrid coupler is limited to less than 20% due to the quarter wavelength transmission line requirement. The amplitude balance becomes rapidly degraded away from the center frequency. We designed, fabricated and tested a high power, ultra-wideband two-section 3 dB coaxial hybrid coupler over all frequencies from 40 MHz to 55 MHz for ITER ICRF system by configuring asymmetric impedance matching. We have designed, fabricated, and tested a 3-dB wideband hybrid coupler for stable and load resilient operation of the ITER ICRF system. The wideband two section 3-dB coaxial hybrid coupler was well designed by configuring asymmetric impedance matching using HFSS. In the rf measurements, we found that wideband hybrid splitter has an amplitude imbalance of 0.1 dB over all frequencies from 40 MHz to 55 MHz. We expect that wideband hybrid splitter will be applicable to ITER ICRF matching system for load resilient operation at fusion plasmas.

  19. Data Fusion Modeling for an RT3102 and Dewetron System Application in Hybrid Vehicle Stability Testing

    Directory of Open Access Journals (Sweden)

    Zhibin Miao

    2015-08-01

    Full Text Available More and more hybrid electric vehicles are driven since they offer such advantages as energy savings and better active safety performance. Hybrid vehicles have two or more power driving systems and frequently switch working condition, so controlling stability is very important. In this work, a two-stage Kalman algorithm method is used to fuse data in hybrid vehicle stability testing. First, the RT3102 navigation system and Dewetron system are introduced. Second, a modeling of data fusion is proposed based on the Kalman filter. Then, this modeling is simulated and tested on a sample vehicle, using Carsim and Simulink software to test the results. The results showed the merits of this modeling.

  20. Mountain bicycle frame testing as an example of practical implementation of hybrid simulation using RTFEM

    Science.gov (United States)

    Mucha, Waldemar; Kuś, Wacław

    2018-01-01

    The paper presents a practical implementation of hybrid simulation using Real Time Finite Element Method (RTFEM). Hybrid simulation is a technique for investigating dynamic material and structural properties of mechanical systems by performing numerical analysis and experiment at the same time. It applies to mechanical systems with elements too difficult or impossible to model numerically. These elements are tested experimentally, while the rest of the system is simulated numerically. Data between the experiment and numerical simulation are exchanged in real time. Authors use Finite Element Method to perform the numerical simulation. The following paper presents the general algorithm for hybrid simulation using RTFEM and possible improvements of the algorithm for computation time reduction developed by the authors. The paper focuses on practical implementation of presented methods, which involves testing of a mountain bicycle frame, where the shock absorber is tested experimentally while the rest of the frame is simulated numerically.

  1. Quality assurance testing of acoustic doppler current profiler transform matrices

    Science.gov (United States)

    Armstrong, Brandy; Fulford, Janice M.; Thibodeaux, Kirk G.

    2015-01-01

    The U.S. Geological Survey (USGS) Hydrologic Instrumentation Facility (HIF) is nationally responsible for the design, testing, evaluation, repair, calibration, warehousing, and distribution of hydrologic instrumentation in use within the USGS Water Mission Area (WMA). The HIF's Hydraulic Laboratory has begun routine quality assurance (QA) testing and documenting the performance of every USGS WMA acoustic Doppler current profiler (ADCP) used for making velocity and discharge measurements. All existing ADCPs are being registered and tracked in a database maintained by the HIF, and called for QA checks in the HIF's Hydraulic Laboratory on a 3- year cycle. All new ADCPs purchased directly from the manufacturer as well as ADCPs sent to the HIF or the manufacturer for repair are being registered and tracked in the database and QA checked in the laboratory before being placed into service. Meters failing the QA check are sent directly to the manufacturer for repairs and rechecked by HIF or removed from service. Although this QA program is specific to the SonTek1 and Teledyne RD Instruments1, ADCPs most commonly used within the WMA, it is the intent of the USGS Office of Surface Water and the HIF to expand this program to include all bottom tracking ADCPs as they become available and more widely used throughout the WMA. As part of the HIF QA process, instruments are inspected for physical damage, the instrument must pass the ADCP diagnostic self-check tests, the temperature probe must be within ± 2 degrees Celsius of a National Institute of Standards and Technology traceable reference thermometer and the distance made good over a fixed distance must meet the manufacturer's specifications (+/-0.25% or +/-1% difference). The transform matrix is tested by conducting distance-made-good (DMG) tests comparing the straight-line distance from bottom tracking to the measured tow-track distance. The DMG test is conducted on each instrument twice in the forward and reverse

  2. Operational Test Report for the 241-AZ-101 Suspended Solids Profiler

    International Nuclear Information System (INIS)

    STENKAMP, D.M.

    2000-01-01

    This document comprises the Operational Test Report for the 241-AZ-101 Suspended Solids Profiler. This document presents the results of Operational Testing of the 241-AZ-101 Suspended Solids Profiler (SSP). Testing of the SSP was performed in accordance with OTP-260-005, ''SUSPENDED SOLIDS PROFILER OPERATIONAL TEST PROCEDURE''. The objective of the testing was to verify that all equipment and components functioned as designed, following construction completion and turnover to operations

  3. Automated model-based testing of hybrid systems

    NARCIS (Netherlands)

    Osch, van M.P.W.J.

    2009-01-01

    In automated model-based input-output conformance testing, tests are automati- cally generated from a speci¯cation and automatically executed on an implemen- tation. Input is applied to the implementation and output is observed from the implementation. If the observed output is allowed according to

  4. Novel Field Test Equipment for Lithium-Ion Batteries in Hybrid Electrical Vehicle Applications

    Directory of Open Access Journals (Sweden)

    Goran Lindbergh

    2011-04-01

    Full Text Available Lifetime testing of batteries for hybrid-electrical vehicles (HEV is usually performed in the lab, either at the cell, module or battery pack level. Complementary field tests of battery packs in vehicles are also often performed. There are, however, difficulties related to field testing of battery-packs. Some examples are cost issues and the complexity of continuously collecting battery performance data, such as capacity fade and impedance increase. In this paper, a novel field test equipment designed primarily for lithium-ion battery cell testing is presented. This equipment is intended to be used on conventional vehicles, not hybrid vehicles, as a cheaper and faster field testing method for batteries, compared to full scale HEV testing. The equipment emulates an HEV environment for the tested battery cell by using real time vehicle sensor information and the existing starter battery as load and source. In addition to the emulated battery cycling, periodical capacity and pulse testing capability are implemented as well. This paper begins with presenting some background information about hybrid electrical vehicles and describing the limitations with today’s HEV battery testing. Furthermore, the functionality of the test equipment is described in detail and, finally, results from verification of the equipment are presented and discussed.

  5. Rotating Beam Fatigue Testing and Hybrid Ceramic Bearings.

    Science.gov (United States)

    1994-07-01

    Runout and Fast Fracture ......... 20 FIG.7 Stress-life Plots of Rotating Beam Fatigue Testing ............. 23 FIG.8 Fractograph of Rotating Beam...Chand-Kare Engineering Ceramics, Worcester, MA. Diamond wheels of 600 grits were used with longitudinal grinding applied for the final finishing of...stress in the range of 600-850 MPa. Three test completion modes were encountered, i.e. fast fracture at setup, fatigue fracture and runout (no failure

  6. The system design and performance test of hybrid vertical axis wind turbine

    Science.gov (United States)

    Dwiyantoro, Bambang Arip; Suphandani, Vivien

    2017-04-01

    Vertical axis wind turbine is a tool that is being developed to generate energy from wind. One cause is still little use of wind energy is the design of wind turbines that are less precise. Therefore in this study will be developed the system design of hybrid vertical axis wind turbine and tested performance with experimental methods. The design of hybrid turbine based on a straight bladed Darrieus turbine along with a double step Savonius turbine. The method used to design wind turbines is by studying literature, analyzing the critical parts of a wind turbine and the structure of the optimal design. Wind turbine prototype of the optimal design characteristic tests in the wind tunnel experimentally by varying the speed of the wind. From the experimental results show that the greater the wind speed, the greater the wind turbine rotation and torque is raised. The hybrid vertical axis wind turbine has much better self-starting and better conversion efficiency.

  7. Lack of detection of human papillomavirus infection by hybridization test in prostatic biopsies

    International Nuclear Information System (INIS)

    Gazzaz, Faten S; Mosli, Hisham A

    2009-01-01

    To explore the possibility of finding human papillomavirus (HPV) infection in the prostate tissue of a cohort of Saudi men presenting with benign prostatic hyperplasia (BPH) or prostate cancer. A cohort study on prospectively collected tissue samples was conducted at King Abdulaziz University Hospital (KAUH), Jeddah, Kingdom of Saudi Arabia from March 2007 to December 2008 on a total of 56 male patients, age range 50-93 years (average 68), diagnosed as having BPH or prostate cancer. The HPV DNA hybridization by hybrid capture 2 technology was performed on prostate biopsies of these patients to detect 18 types of HPV infection, and differentiate between 2 HPV DNA groups, the low-risk types, and the high/intermediate risk types.The tissues of all the prostatic biopsies were negative for HPV DNA. Our results, using the hybridization test, indicate that it is unlikely that HPV-16 or HPV-18, or the other tested subtypes, enhance the risk of prostate cancer. (author)

  8. Targeted and untargeted high resolution mass approach for a putative profiling of glycosylated simple phenols in hybrid grapes.

    Science.gov (United States)

    Barnaba, Chiara; Dellacassa, Eduardo; Nicolini, Giorgio; Giacomelli, Mattia; Roman Villegas, Tomas; Nardin, Tiziana; Larcher, Roberto

    2017-08-01

    Vitis vinifera is one of the most widespread grapevines around the world representing the raw material for high quality wine production. The availability of more resistant interspecific hybrid vine varieties, developed from crosses between Vitis vinifera and other Vitis species, has generated much interest, also due to the low environmental effect of production. However, hybrid grape wine composition and varietal differences between interspecific hybrids have not been well defined, particularly for the simple phenols profile. The dynamic of these phenols in wines, where the glycosylated forms can be transformed into the free ones during winemaking, also raises an increasing health interest by their role as antoxidants in wine consumers. In this work an on-line SPE clean-up device, to reduce matrix interference, was combined with ultra-high liquid chromatography-high resolution mass spectrometry in order to increase understanding of the phenolic composition of hybrid grape varieties. Specifically, the phenolic composition of 4 hybrid grape varieties (red, Cabernet Cantor and Prior; white, Muscaris and Solaris) and 2 European grape varieties (red, Merlot; white, Chardonnay) was investigated, focusing on free and glycosidically bound simple phenols and considering compound distribution in pulp, skin, seeds and wine. Using a targeted approach 53 free simple phenols and 7 glycosidic precursors were quantified with quantification limits ranging from 0.001 to 2mgKg -1 and calibration R 2 of 0.99 for over 86% of compounds. The untargeted approach made it possible to tentatively identify 79 glycosylated precursors of selected free simple phenols in the form of -hexoside (N=30), -pentoside (21), -hexoside-hexoside (17), -hexoside-pentoside (4), -pentoside-hexoside (5) and -pentoside-pentoside (2) derivatives on the basis of accurate mass, isotopic pattern and MS/MS fragmentation. Copyright © 2017 Elsevier Ltd. All rights reserved.

  9. CORRELATION BETWEEN SEED TESTS AND FIELD EMERGENCE OF TWO MAIZE HYBRIDS (SC704 AND SC500)

    OpenAIRE

    A.A. ALILOO; B. SHOKATI

    2011-01-01

    Early emergence and stand establishment of maize (Zea mays L.) are considered to be the most important yield-contributing factors. The influence of seed vigor on these factors is vital. Therefore, five laboratory tests and field experiment were conducted on basis of a randomized complete block design (RCBD) with five replications in 2011, to evaluate the correlation among the seed vigor tests and field emergence of two maize hybrids (SC704 and SC500). In laboratory tests, differences between ...

  10. Extensive tests of Hybrid Photon Detectors (HPD) used to collect Cherenkov light

    International Nuclear Information System (INIS)

    Borsato, E.; Buccheri, A.; DalCorso, F.; Ferroni, F.; Iacovella, F.; Mazzoni, M.A.; Morandin, M.; Morganti, S.; Piredda, G.; Posocco, M.; Santacesaria, R.; Stroili, R.; Torassa, E.; Voci, C.

    1997-01-01

    The principle of operation of a newly developed proximity focused Hybrid Photon Detector is described. The HPD characteristics, performance and calibration are reported. Results from beam tests of aerogel threshold counters read out by HPD and the particle identification performance are presented. (orig.)

  11. Hybrid propulsion testing using direct-drive electrical machines for super yacht and inland shipping

    NARCIS (Netherlands)

    Paulides, J.J.H.; Djukic, N.; de Roon, J.A.; Encica, L.

    2016-01-01

    Hybrid or full electric propulsions for inland ships are becoming more popular. In these application, direct-drive PM propulsion motors are a preferred machine configuration. This paper discusses the challenges to determine the losses, as estimated with simulations, during the testing procedures of

  12. Verification of hybrid analysis concept of soil-foundation interaction by field vibration tests. Pt. 2

    International Nuclear Information System (INIS)

    Katayama, I.; Niwa, A.; Kubo, Y.; Penzien, J.

    1987-01-01

    The paper describes the outline of the hybrid analysis code for soil-structure interaction (HASSI) and the results of numerical simulation of the responses obtained at the model 2C in both cases of the forced vibration test and the natural earthquake excitation. (orig./HP)

  13. Substructure hybrid testing of reinforced concrete shear wall structure using a domain overlapping technique

    Science.gov (United States)

    Zhang, Yu; Pan, Peng; Gong, Runhua; Wang, Tao; Xue, Weichen

    2017-10-01

    An online hybrid test was carried out on a 40-story 120-m high concrete shear wall structure. The structure was divided into two substructures whereby a physical model of the bottom three stories was tested in the laboratory and the upper 37 stories were simulated numerically using ABAQUS. An overlapping domain method was employed for the bottom three stories to ensure the validity of the boundary conditions of the superstructure. Mixed control was adopted in the test. Displacement control was used to apply the horizontal displacement, while two controlled force actuators were applied to simulate the overturning moment, which is very large and cannot be ignored in the substructure hybrid test of high-rise buildings. A series of tests with earthquake sources of sequentially increasing intensities were carried out. The test results indicate that the proposed hybrid test method is a solution to reproduce the seismic response of high-rise concrete shear wall buildings. The seismic performance of the tested precast high-rise building satisfies the requirements of the Chinese seismic design code.

  14. Development and Testing of a Two-Stage Hybrid Launcher.

    Science.gov (United States)

    1979-10-31

    more unitorm properties thorough the tuicK section by quencning in a salt batn, thereby minimizing the cooling gradient but pruuucing a bainitic steel ...to to 1990 psig with H2 , then 6 capture (embed) steel diaphragm fragments S-1, 11/28/77 Diaphragm To devise a method to seal drivers without * Built...driver along with nyloi S-2, and (plug) using steel diaphragms, which add significant release system, and plug cato S-3 11/29/77 tests amounts of

  15. Development of a test facility for PV-Wind hybrid energy systems

    Energy Technology Data Exchange (ETDEWEB)

    Engin, Mustafa [Ege Univ., Izmir (Turkey). Ege Tech., Electronics Technolgy; Ege Univ., Izmir (Turkey). Solar Energy Inst.

    2010-07-01

    To quantify the potential for performance improvements of photovoltaic-wind hybrid energy systems, a test facility has been installed at the Solar Energy Institute, Ege University. Hybrid system consist of a wind turbine, PV array, battery, AC and DC loads, inverters, charge regulators and a data logging and control unit. The collected data are first conditioned using precision electronic circuits and then interfaced to a PC using a data logging unit. The LABVIEW program is used to further process, display and store the collected data in the PC disk. The proposed data logging and control unit permits the rapid system development and has the advantage of flexibility in the case of changes, while it can be easily extended for controlling the of photovoltaic-wind hybrid energy system operation. (orig.)

  16. Neuro-Fuzzy Prediction of Cooperation Interaction Profile of Flexible Road Train Based on Hybrid Automaton Modeling

    Directory of Open Access Journals (Sweden)

    Banjanovic-Mehmedovic Lejla

    2016-01-01

    Full Text Available Accurate prediction of traffic information is important in many applications in relation to Intelligent Transport systems (ITS, since it reduces the uncertainty of future traffic states and improves traffic mobility. There is a lot of research done in the field of traffic information predictions such as speed, flow and travel time. The most important research was done in the domain of cooperative intelligent transport system (C-ITS. The goal of this paper is to introduce the novel cooperation behaviour profile prediction through the example of flexible Road Trains useful road cooperation parameter, which contributes to the improvement of traffic mobility in Intelligent Transportation Systems. This paper presents an approach towards the control and cooperation behaviour modelling of vehicles in the flexible Road Train based on hybrid automaton and neuro-fuzzy (ANFIS prediction of cooperation profile of the flexible Road Train. Hybrid automaton takes into account complex dynamics of each vehicle as well as discrete cooperation approach. The ANFIS is a particular class of the ANN family with attractive estimation and learning potentials. In order to provide statistical analysis, RMSE (root mean square error, coefficient of determination (R2 and Pearson coefficient (r, were utilized. The study results suggest that ANFIS would be an efficient soft computing methodology, which could offer precise predictions of cooperative interactions between vehicles in Road Train, which is useful for prediction mobility in Intelligent Transport systems.

  17. Aerogel Hybrid Composite Materials: Designs and Testing for Multifunctional Applications

    Science.gov (United States)

    Williams, Martha K.; Fesmire, James E.

    2016-01-01

    This webinar will introduce the broad spectrum of aerogel composites and their diverse performance properties such as reduced heat transfer to energy storage, and expands specifically on the aerogel/fiber laminate systems and testing methodologies. The multi-functional laminate composite system, AeroFiber, and its construction is designed by varying the type of fiber (e.g. polyester, carbon, Kevlar®, Spectra® or Innegral(TradeMark) and combinations thereof), the aerogel panel type and thickness, and overall layup configuration. The combination and design of materials may be customized and tailored to achieve a range of desired properties in the resulting laminate system. Multi-functional properties include structural strength, impact resistance, reduction in heat transfer, increased fire resistance, mechanical energy absorption, and acoustic energy dampening. Applications include aerospace, aircraft, automotive, boating, building and construction, lightweight portable structures, liquefied natural gas, cryogenics, transportation and energy, sporting equipment, and military protective gear industries.

  18. Tensile and Flexural Test on Kenaf Hybrid Composites

    Science.gov (United States)

    Salleh, Z.; Yunus, S.; Masdek, N. R. N. M.; Taib, Y. M.; Azhar, I. I. S.; Hyie, K. M.

    2018-03-01

    The widely use of synthetic materials like carbon and fiberglass in various industries such as automotive and aircraft has lead to human health and environment problems. Therefore, the use of natural fibres such as kenaf has received higher attention as reinforcement. Kenaf or the scientific name is Hibiscus Cannabinus. L is one of the group of Malvecea plant which in the early days, the application of kenaf served only rope and canvas. However, it has more advantages than synthetic materials such as; widely availaible, renewable, lightweight, non-abbrasiveness during processing, high specific strength, free from health hazard and biodegradeable. This study was carried out to investigate the effects of different arrangement of kenaf and fiberglass composites on Young’s Modulus. The material composite was hardened with polyester resin and their properties was characterized. The tensile and the flexural properties is determined using an Instron universal tensile testing machine and carried out by following ASTM D3039 for tensile and ASTM D790 for a flexural test. The experimental program was designed to correlate the flexural and tensile Young’s Modulus of kenaf and fiberglass composite under the same load condition but different arrangement of kenaf and fiberglass on the mold . The resistance to change in shape was described by the behavior and characteristic of the composite materials. The stiffness or the elastic modulus of the composite material was determined at the end of the experiment. The results obtained show that the [±90FG/0/90/90/0/±90FG] kenaf/fiberglass composite arrangement has the highest elastic value.

  19. Hybrid Wing Body Multi-Bay Test Article Analysis and Assembly Final Report

    Science.gov (United States)

    Velicki, Alexander; Hoffman, Krishna; Linton, Kim A.; Baraja, Jaime; Wu, Hsi-Yung T.; Thrash, Patrick

    2017-01-01

    This report summarizes work performed by The Boeing Company, through its Boeing Research & Technology organization located in Huntington Beach, California, under the Environmentally Responsible Aviation (ERA) project. The report documents work performed to structurally analyze and assemble a large-scale Multi-bay Box (MBB) Test Article capable of withstanding bending and internal pressure loadings representative of a Hybrid Wing Body (HWB) aircraft. The work included fabrication of tooling elements for use in the fabrication and assembly of the test article.

  20. Verification of hybrid analysis concept of soil-foundation interaction by field vibration tests - Analytical phase

    International Nuclear Information System (INIS)

    Katayama, I.; Niwa, A.; Kubo, Y.; Penzien, J.

    1987-01-01

    In connection with the previous paper under the same subject, which describes the results obtained by the field vibration tests of five different models, this paper describes the outline of the hybrid analysis code of soil-structure interaction (HASSI) and the results of numerical simulation of the responses obtained at the model 2C in both cases of the forced vibration test and the natural earthquake excitation

  1. Increased adolescent HIV testing with a hybrid mobile strategy in Uganda and Kenya.

    Science.gov (United States)

    Kadede, Kevin; Ruel, Theodore; Kabami, Jane; Ssemmondo, Emmanuel; Sang, Norton; Kwarisiima, Dalsone; Bukusi, Elizabeth; Cohen, Craig R; Liegler, Teri; Clark, Tamara D; Charlebois, Edwin D; Petersen, Maya L; Kamya, Moses R; Havlir, Diane V; Chamie, Gabriel

    2016-09-10

    We sought to increase adolescent HIV testing across rural communities in east Africa and identify predictors of undiagnosed HIV. Hybrid mobile testing. We enumerated 116 326 adolescents (10-24 years) in 32 communities of Uganda and Kenya ( NCT01864603): 98 694 (85%) reported stable (≥6 months of prior year) residence. In each community we performed hybrid testing: 2-week multidisease community health campaign that included HIV testing, followed by home-based testing of community health campaign nonparticipants. We measured adolescent HIV testing coverage and prevalence, and determined predictors of newly diagnosed HIV among HIV-infected adolescents using multivariable logistic regression. A total of 86 421 (88%) stable adolescents tested for HIV; coverage was 86, 90, and 88% in early (10-14), mid (15-17), and late (18-24) adolescents, respectively. Self-reported prior testing was 9, 26, and 55% in early, mid, and late adolescents tested, respectively. HIV prevalence among adolescents tested was 1.6 and 0.6% in Ugandan women and men, and 7.1 and 1.5% in Kenyan women and men, respectively. Prevalence increased in mid-adolescence for women and late adolescence for men. Among HIV-infected adolescents, 58% reported newly diagnosed HIV. In multivariate analysis of HIV-infected adolescents, predictors of newly diagnosed HIV included male sex [odds ratio (OR) = 1.97 (95% confidence interval (CI): 1.42-2.73)], Ugandan residence [OR = 2.63 (95% CI: 2.08-3.31)], and single status [OR = 1.62 (95% CI: 1.23-2.14) vs. married)]. The SEARCH hybrid strategy tested 88% of stable adolescents for HIV, a substantial increase over the 28% reporting prior testing. The majority (57%) of HIV-infected adolescents were new diagnoses. Mobile HIV testing for adults should be leveraged to reach adolescents for HIV treatment and prevention.

  2. HYBRID CONTINUUM-DISCONTINUUM MODELLING OF ROCK FRACUTRE PROCESS IN BRAZILIAN TENSILE STRENGTH TEST

    Directory of Open Access Journals (Sweden)

    Huaming An

    2017-10-01

    Full Text Available A hybrid continuum-discontinuum method is introduced to model the rock failure process in Brazilian tensile strength (BTS test. The key component of the hybrid continuum-discontinuum method, i.e. transition from continuum to discontinuum through fracture and fragmentation, is introduced in detail. A laboratory test is conducted first to capture the rock fracture pattern in the BTS test while the tensile strength is calculated according to the peak value of the loading forces. Then the proposed method is used to model the rock behaviour during BTS test. The stress propagation is modelled and compared with those modelled by finite element method in literatures. In addition, the crack initiation and propagation are captured and compared with the facture patter in laboratory test. Moreover, the force-loading displacement curve is obtained which represents a typical brittle material failure process. Furthermore, the stress distributions along the vertical direction are compared with the theoretical solution. It is concluded that the hybrid continuum-discontinuum method can model the stress propagation process and the entire rock failure process in BTS test. The proposed method is a valuable numerical tool for studying the rock behaviour involving the fracture and fragmentation processes.

  3. HYBRID DATA APPROACH FOR SELECTING EFFECTIVE TEST CASES DURING THE REGRESSION TESTING

    OpenAIRE

    Mohan, M.; Shrimali, Tarun

    2017-01-01

    In the software industry, software testing becomes more important in the entire software development life cycle. Software testing is one of the fundamental components of software quality assurances. Software Testing Life Cycle (STLC)is a process involved in testing the complete software, which includes Regression Testing, Unit Testing, Smoke Testing, Integration Testing, Interface Testing, System Testing & etc. In the STLC of Regression testing, test case selection is one of the most importan...

  4. Correlating Dynamometer Testing to In-Use Fleet Results of Plug-In Hybrid Electric Vehicles

    Energy Technology Data Exchange (ETDEWEB)

    John G. Smart; Sera White; Michael Duoba

    2009-05-01

    Standard dynamometer test procedures are currently being developed to determine fuel and electrical energy consumption of plug-in hybrid vehicles (PHEV). To define a repeatable test procedure, assumptions were made about how PHEVs will be driven and charged. This study evaluates these assumptions by comparing results of PHEV dynamometer testing following proposed procedures to actual performance of PHEVs operating in the US Department of Energy’s (DOE) North American PHEV Demonstration fleet. Results show PHEVs in the fleet exhibit a wide range of energy consumption, which is not demonstrated in dynamometer testing. Sources of variation in performance are identified and examined.

  5. Comparison of test performance profile for blood tests of liver fibrosis in chronic hepatitis C.

    Science.gov (United States)

    Halfon, Philippe; Bacq, Yannick; De Muret, Anne; Penaranda, Guillaume; Bourliere, Marc; Ouzan, Denis; Tran, Albert; Botta, Danielle; Renou, Christophe; Bréchot, Marie-Claude; Degott, Claude; Paradis, Valérie

    2007-03-01

    We evaluated the test performance profile (TPP) of blood tests of liver fibrosis. Three hundred and fifty-six patients with C chronic hepatitis were included in two centers. Metavir staging of liver specimens by two independent pathologists and the following tests were evaluated: Fibrotest (FT), APRI, FibroMeter (FM), and Hepascore (HS). Metavir stages were: F0: 4%, F1: 55%, F2: 26%, F3: 11%, and F4: 4%. The AUROCs were not significantly different, respectively, FT, FM, APRI, HS: >or=F2: 0.79, 0.78, 0.76, >or=0.76; F3: 0.81, 0.85, 0.81, 0.81; and F4: 0.86, 0.94, 0.92, 0.89. The TPP relies on the paired comparison of blood-test misclassification based on liver specimen, e.g. FT vs FM, respectively: F0+1: 18 vs 28% (p=0.0003), >or=F2: 43 vs 31% (p=0.004). There was no center effect. In those populations, the four blood tests had a similar performance for significant fibrosis (F>or=2), lying in the lower range of published results which is attributable to a low >or=F2 prevalence, and for >or=F3 and F4. However, FM and FT had performance profiles significantly different as a function of fibrosis stages or diagnostic target (fibrosis cut-off). This has to be considered during the interpretation process. Moreover, the performance should be reported with different diagnostic targets.

  6. Inheritance profile of weathered chlordane and p,p'-DDTs accumulation by Cucurbita pepo hybrids.

    Science.gov (United States)

    Isleyen, Mehmet; Sevim, Pinar; Hawthorne, Joseph; Berger, William; White, Jason C

    2013-01-01

    Cucurbita pepo ssp pepo (zucchini) accumulates significant levels of persistent organic pollutants in its roots, followed by unexpectedly high contaminant translocation to the stems. Most other plant species, including the closely related C. pepo ssp ovifera (squash), do not have this ability. To investigate the mechanism of contaminant accumulation, two cultivars each of parental zucchini and squash, as well as previously created first filial (F1) hybrids and F1 backcrosses (BC) of those parental cultivars, were grown under field conditions in a soil contaminated with weathered chlordane (2.29 microg/g) and DDX residues (0.30 microg/g; sum of DDT, DDE, DDD). The parental zucchini had stem-to-soil bioconcentration factors (BCF, contaminant ratio of stem to soil) for chlordane and DDX of 6.23 and 3.10; these values were 2.2 and 3.7 times greater than the squash, respectively. Chlordane and DDX translocation factors, the ratio of contaminant content in the stems to that in the root, were 2.1 and 3.2 times greater for zucchini than for squash. The parental zucchini and squash also differed significantly in chlordane component ratios (relative amounts of trans-nonachlor [TN], cis-chlordane [CC], trans-chlordane [TC]) and enantiomer fractions for the chiral CC and TC. Hybridization of the parental squash and zucchini resulted in significant differences in contaminant uptake. For both the three separate component ratios (CR) and two sets of enantiomer fraction (EF) values, subspecies specific differences in the parental generation became statistically equivalent in the F1 hybrid zucchini and squash. When backcrossed (BC) with the original parental plants, the zucchini and squash F1 BC cultivars reverted to the statistically distinct CR and EF patterns. This pattern of trait segregation upon hybridization suggests either single gene or single locus control for persistent organic pollutant (POP) uptake ability by C. pepo ssp pepo.

  7. Heat-Mirror Spectral Profile Optimization for TSC Hybrid Solar Conversion

    Science.gov (United States)

    Soule, D. E.; Wood, S. E.

    1986-09-01

    The efficiencies for total solar cogeneration (TSC) can be optimized by tailoring the transparent heat-mirror (HM) beam splitter spectral profile shape. The entire output is cogenerated by photovoltaic/photothermal conversions into three energy forms: electricity (PV) 18V d.c./module, high-temperature heat (HT) 400°C, and low-temperature heat (LT) 70°C. The emphasis is to maximize the high-quality energy sum PV + HT, while maintaining PV at a high level. A generalized 5-parameter double Fermi model for the HM spectral profile is investigated allowing for a wide parametric range and profile asymmetry. The projected optimized TSC conversion efficiencies are: PV = 14.3%, HT = 43.5%, and LT = 42.2% with a high-quality energy sum of PV + HT = 57.8%. The approach to this optimum HM spectral profile by experimental HM films such as ITO are discussed.

  8. Voltage Profile Enhancement and Reduction of Real Power loss by Hybrid Biogeography Based Artificial Bee Colony algorithm

    Directory of Open Access Journals (Sweden)

    K. Lenin

    2014-04-01

    Full Text Available This paper presents Hybrid Biogeography algorithm for solving the multi-objective reactive power dispatch problem in a power system. Real Power Loss minimization and maximization of voltage stability margin are taken as the objectives. Artificial bee colony optimization (ABC is quick and forceful algorithm for global optimization. Biogeography-Based Optimization (BBO is a new-fangled biogeography inspired algorithm. It mainly utilizes the biogeography-based relocation operator to share the information among solutions. In this work, a hybrid algorithm with BBO and ABC is projected, and named as HBBABC (Hybrid Biogeography based Artificial Bee Colony Optimization, for the universal numerical optimization problem. HBBABC merge the searching behavior of ABC with that of BBO. Both the algorithms have different solution probing tendency like ABC have good exploration probing tendency while BBO have good exploitation probing tendency.  HBBABC used to solve the reactive power dispatch problem and the proposed technique has been tested in standard IEEE30 bus test system.

  9. Comparison of Fluorescence In Situ Hybridization and Chromogenic In Situ Hybridization for Low and High Throughput HER2 Genetic Testing

    DEFF Research Database (Denmark)

    Poulsen, Tim S; Espersen, Maiken Lise Marcker; Kofoed, Vibeke

    2013-01-01

    cancer patients with HER2 immunohistochemistry (IHC) results scored as 0/1+, 2+, and 3+. HER2 genetic status was analysed using chromogenic in situ hybridization (CISH) and fluorescence in situ hybridization (FISH). Scoring results were documented through digital image analysis. The cancer region...

  10. Development and Testing of a Mobile Robot with Hybrid Legged-Wheeled Locomotion

    Directory of Open Access Journals (Sweden)

    Petre Barbu

    2017-06-01

    Full Text Available In this paper the authors present the development and testing process of a mobile robot with hybrid legged-wheeled locomotion, that can be used for exploring dangerous environments. The robot has a high adaptability to rough terrain by being able to modify its ride height, to overpass step or ditch type obstacles and most of all, being able to operate while overturned or to revert itself into the normal operating position.

  11. Full Scale Model Test of Consolidation Acceleration on Soft Soil deposition with Combination of Timber Pile and PVD (Hybrid Pile)

    OpenAIRE

    Sandyutama, Y.; Samang, L.; Imran, A. M.; Harianto4, T.

    2015-01-01

    This research aims to analyze the effect of composite pile-PVD (hybrid pile) as the reinforcement in embankment on soft soil by the means of numerical simulation and Full-Scale Trial Embankment. The first phase cunducted by numerical analysis and obtained 6-8 meters hybrid pile length effective. Full-Scale trial embankment. was installed hybrid pile of 6 m and preloading of 4,50 height. Full-scale tests were performed to investigate the performances of Hybrid pile reinforcement. This research...

  12. Hybrid III anthropomorphic test device (ATD) response to head impacts and potential implications for athletic headgear testing.

    Science.gov (United States)

    Bartsch, Adam; Benzel, Edward; Miele, Vincent; Morr, Douglas; Prakash, Vikas

    2012-09-01

    The Hybrid III 50th percentile male anthropomorphic test device (ATD) is the most widely used human impact testing surrogate and has historically been used in automotive or military testing. More recently, this ATD is finding use in applications evaluating athletic helmet protectivity, quantifying head impact dosage and estimating injury risk. But ATD head-neck response has not been quantified in omnidirectional athletic-type head impacts absent axial preload. It is probable that headgear injury reduction that can be quantified in a laboratory, including in American football, boxing, hockey, lacrosse and soccer, is related to a number of interrelated kinetic and kinematic factors, such as head center of gravity linear acceleration, head angular acceleration, head angular velocity, occipito-cervical mechanics and neck stiffness. Therefore, we characterized ATD head-neck dynamic response to direct head impacts in a series of front, oblique front and lateral head impacts. Key findings were: (1) impacts producing highest ATD resultant center of gravity linear acceleration resulted in the lowest resultant occipito-cervical spine bending moment/force. (2) Resultant ATD head angular velocity and angular acceleration did not appear coupled to impact direction at lower impact energy levels; these parameters were coupled at higher energy levels. (3) The ATD had progressively increasing occipito-cervical stiffness in extension, torsion and lateral bending, respectively. Because the ATD neck influenced head and neck impact dosage parameters, testing agencies, manufacturers and researchers should consider using the Hybrid III head form attached to a neck as a means to quantify head and neck injury risks as opposed to systems that do not utilize a neck. This heightened understanding of Hybrid III ATD head-neck response, and consideration of order of stiffest axes in the lateral, oblique and extension directions, respectively, should aid in the development of head and neck injury

  13. Use of predefined biochemical admission profiles does not reduce the number of tests or total cost

    DEFF Research Database (Denmark)

    Pareek, Manan; Haidl, Felix; Folkestad, Lars

    2014-01-01

    The objective of this pilot study was to evaluate whether the use of predefined biochemical profiles as an alternative to individually ordered blood tests by the treating physicians resulted in fewer tests or a lower total cost.......The objective of this pilot study was to evaluate whether the use of predefined biochemical profiles as an alternative to individually ordered blood tests by the treating physicians resulted in fewer tests or a lower total cost....

  14. Linkage of cDNA expression profiles of mesencephalic dopaminergic neurons to a genome-wide in situ hybridization database

    Directory of Open Access Journals (Sweden)

    Simon Horst H

    2009-01-01

    Full Text Available Abstract Midbrain dopaminergic neurons are involved in control of emotion, motivation and motor behavior. The loss of one of the subpopulations, substantia nigra pars compacta, is the pathological hallmark of one of the most prominent neurological disorders, Parkinson's disease. Several groups have looked at the molecular identity of midbrain dopaminergic neurons and have suggested the gene expression profile of these neurons. Here, after determining the efficiency of each screen, we provide a linked database of the genes, expressed in this neuronal population, by combining and comparing the results of six previous studies and verification of expression of each gene in dopaminergic neurons, using the collection of in situ hybridization in the Allen Brain Atlas.

  15. Ciprofloxacin-intercalated Zinc Layered Hydroxides Hybrid Material: Synthesis and in Vitro Release Profiles of an Antibiotic Compound

    International Nuclear Information System (INIS)

    Mohd Zobir Hussein; Mohd Zobir Hussein; Stanslas, J.; Abdul Halim Abdullah

    2011-01-01

    The intriguing anion exchange properties of layered hydroxides salts, combined with its high layer charge density have provided strong motivations for the potential use of the inorganic layered host material in drug delivery applications. Ciprofloxacin (CFX), a wide spectrum antibiotic has been anion exchanged with nitrate of zinc hydroxide nitrate (ZHN), which belongs to the LHS family, resulted in the expansion of the basal spacing from 9.92 Amstrom of ZHN to 21.5 Angstrom of ZCFX, the obtained hybrid material. Other characterizations, such as Fourier transform infra red spectroscopy (FTIR), CHNS analysis and TGA/ DTG have further corroborated this finding. Electron microscopy study reveals the plate-like structure of the nano hybrid material. The in vitro release of CFX was performed in phosphate saline buffer at pH 7.4 and it behaves in a slow and sustained release profile over a period of 72 hours. This study suggests that ZHN, which demonstrates a controlled release behavior, could be a potential host material in the drug delivery applications. (author)

  16. Integrated Optimization of Speed Profiles and Power Split for a Tram with Hybrid Energy Storage Systems on a Signalized Route

    Directory of Open Access Journals (Sweden)

    Zhuang Xiao

    2018-02-01

    Full Text Available A tram with on-board hybrid energy storage systems based on batteries and supercapacitors is a new option for the urban traffic system. This configuration enables the tram to operate in both catenary zones and catenary-free zones, and the storage of regenerative braking energy for later usage. This paper presents a multiple phases integrated optimization (MPIO method for the coordination of speed profiles and power split considering the signal control strategy. The objective is to minimize the equivalent total energy consumption of all the power sources, which includes both the energy from the traction substation and energy storage systems. The constraints contain running time, variable gradients and curves, speed limits, power balance and signal time at some intersections. The integrated optimization problem is formulated as a multiple phases model based on the characters of the signalized route. An integrated calculation framework, using hp-adaptive pseudospectral method, is proposed for the integrated optimization problem. The effectiveness of the method is verified under fixed time signal (FTS control strategy and tram priority signal (TPS control strategy. Illustrative results show that this method can be successfully applied for trams with hybrid energy storage systems to improve their energy efficiency.

  17. Dynamic simulation of a fuel cell hybrid vehicle during the federal test procedure-75 driving cycle

    International Nuclear Information System (INIS)

    Kang, Sanggyu; Min, Kyoungdoug

    2016-01-01

    Highlights: • Development of a FCHV dynamic model. • Integration of a PEMFC system dynamic model with the electric vehicle model. • Investigation of the dynamic behavior of the FCEV and PEMFC system during FTP-75. • Capturing the dynamic correlation among components in PEMFC system during FTP-75. - Abstract: The dynamic behavior of a proton exchange membrane fuel cell (PEMFC) system is a crucial factor to ensure the safe and effective operation of fuel cell hybrid vehicles (FCHVs). Specifically, water and thermal management are critical to stabilize the performance of the PEMFC during severe load changes. In the present study, the FCHV dynamic model is developed. The dynamic model of the PEMFC system developed by Matlab–Simulink® is integrated into the electric vehicle model embedded in the Amesim®. The dynamic model of the PEMFC system is composed of a PEMFC stack, an air feeding system, and a thermal management system (TMS). The component models of PEMFC, a shell-and-tube gas-to-gas membrane humidifier, and a heat exchanger are validated via a comparison with the experimental data. The FCHV model is simulated during a federal test procedure (FTP)-75 driving cycle. One system configuration and control strategy is adopted to attain optimal water and thermal management in the PEMFC system. The vehicle speed obtained from the FCHV model aptly tracks the target velocity profile of the FTP-75 cycle within an error of ±0.5%. The dynamic behavior and correlation of each component in the PEMFC system is investigated. The mass and heat transfer in the PEMFC, a humidifier, and a heat exchanger are resolved to determine the species concentration and the temperature more accurately with discretization in the flow’s perpendicular direction. Discretization in the flow parallel direction of humidifier and heat exchanger model makes it possible to capture the distribution of the characteristics. The present model can be used to attain the optimization of the system

  18. Drift Wave Test Particle Transport in Reversed Shear Profile

    International Nuclear Information System (INIS)

    Horton, W.; Park, H.B.; Kwon, J.M.; Stronzzi, D.; Morrison, P.J.; Choi, D.I.

    1998-01-01

    Drift wave maps, area preserving maps that describe the motion of charged particles in drift waves, are derived. The maps allow the integration of particle orbits on the long time scale needed to describe transport. Calculations using the drift wave maps show that dramatic improvement in the particle confinement, in the presence of a given level and spectrum of E x B turbulence, can occur for q(r)-profiles with reversed shear. A similar reduction in the transport, i.e. one that is independent of the turbulence, is observed in the presence of an equilibrium radial electric field with shear. The transport reduction, caused by the combined effects of radial electric field shear and both monotonic and reversed shear magnetic q-profiles, is also investigated

  19. Mechanistic profiling of the siRNA delivery dynamics of lipid-polymer hybrid nanoparticles

    DEFF Research Database (Denmark)

    Colombo, Stefano; Cun, Dongmei; Remaut, Katrien

    2015-01-01

    Understanding the delivery dynamics of nucleic acid nanocarriers is fundamental to improve their design for therapeutic applications. We investigated the carrier structure-function relationship of lipid-polymer hybrid nanoparticles (LPNs) consisting of poly(dl-lactic-co-glycolic acid) (PLGA) nano...... of transfection-competent siRNA-DOTAP lipoplexes from the LPNs. Based on these results, we suggest a model for the nanostructural characteristics of the LPNs, in which the siRNA is organized in lamellar superficial assemblies and/or as complexes entrapped in the polymeric matrix.......Understanding the delivery dynamics of nucleic acid nanocarriers is fundamental to improve their design for therapeutic applications. We investigated the carrier structure-function relationship of lipid-polymer hybrid nanoparticles (LPNs) consisting of poly(dl-lactic-co-glycolic acid) (PLGA......) nanocarriers modified with the cationic lipid dioleoyltrimethyl-ammoniumpropane (DOTAP). A library of siRNA-loaded LPNs was prepared by systematically varying the nitrogen-to-phosphate (N/P) ratio. Atomic force microscopy (AFM) and cryo-transmission electron microscopy (cryo-TEM) combined with small angle X...

  20. Design of Jet lower hybrid current drive generator and operation of high power test bed

    International Nuclear Information System (INIS)

    Dobbing, J.A.; Bosia, G.; Brandon, M.; Gammelin, M.; Gormezano, C.; Jacquinot, J.; Jessop, G.; Lennholm, M.; Pain, M.; Sibley, A.

    1989-01-01

    The JET Lower Hybrid Current Drive (LHCD) generator consists of 24 klystrons each rated for 650 KW operating at 3.7 GHz, giving a nominal generator power of 15.6 MW for 10 seconds or 12 MW for 20 seconds. This power will be transmitted through 24 waveguides to a phased array launcher on one of the main ports of the JET machine. In addition, two klystrons are currently being operated on a high power test bed to establish reliable operation of the generators components and test high power microwave components prior to their installation

  1. ACER Mathematics Profile Series: Number Test. (Test Booklet, Answer and Record Sheet, Score Key, and Teachers Handbook).

    Science.gov (United States)

    Cornish, Greg; Wines, Robin

    The Number Test of the ACER Mathematics Profile Series, contains 30 items, for each of three suggested grade levels: 7-8, 8-9, and 9-10. Raw scores on all tests in the ACER Mathematics Profile Series (Number, Operations, Space and Measurement) are converted to a common scale called MAPS, a major feature of the Series. Based on the Rasch Model,…

  2. High power tests of beryllium oxide windows to the lower hybrid current drive launcher in JET

    International Nuclear Information System (INIS)

    Ekedahl, A.; Brandon, M.; Finburg, P.

    1999-01-01

    The vacuum windows to the 3.70 GHz Lower Hybrid Current Drive (LHCD) system in JET were originally designed to withstand 350 kW for 20 s with VSWR ≤ 1.8. High power RF tests of the windows have been carried out in the LHCD test facility at JET. All windows that were tested could operate at 500 kW for 10 s in a matched load. Two windows passed an endurance test at 250 kW for 20 s with the windows terminated in a short circuit. One window also passed this endurance test without active cooling. The results show that this type of window can be used in a new advanced launcher, as proposed for ITER, in which the output power from each klystron (P ≤ 500 kW) will be transmitted through one waveguide and one vacuum window. (author)

  3. The large-area hybrid-optics CLAS12 RICH detector: Tests of innovative components

    International Nuclear Information System (INIS)

    Contalbrigo, M.; Baltzell, N.; Benmokhtar, F.; Barion, L.; Cisbani, E.; El Alaoui, A.; Hafidi, K.; Hoek, M.; Kubarovsky, V.; Lagamba, L.; Lucherini, V.; Malaguti, R.; Mirazita, M.; Montgomery, R.; Movsisyan, A.; Musico, P.; Orecchini, D.; Orlandi, A.; Pappalardo, L.L.; Pereira, S.

    2014-01-01

    A large area ring-imaging Cherenkov detector has been designed to provide clean hadron identification capability in the momentum range from 3 GeV/c to 8 GeV/c for the CLAS12 experiments at the upgraded 12 GeV continuous electron beam accelerator facility of Jefferson Lab to study the 3D nucleon structure in the yet poorly explored valence region by deep-inelastic scattering, and to perform precision measurements in hadronization and hadron spectroscopy. The adopted solution foresees a novel hybrid optics design based on an aerogel radiator, composite mirrors and densely packed and highly segmented photon detectors. Cherenkov light will either be imaged directly (forward tracks) or after two mirror reflections (large angle tracks). The preliminary results of individual detector component tests and of the prototype performance at test-beams are reported here. - Highlights: • A novel hybrid-optics configuration was proven to work with a large RICH prototype. • Innovative RICH components were studied both in laboratory tests and test-beams. • Aerogel of large Rayleigh scattering length at n=1.05 was characterized. • Novel vs commercially available multi-anode photomultipliers were compared. • The response of SiPM matrices to Cherenkov light was tested at various temperatures

  4. The large-area hybrid-optics CLAS12 RICH detector: Tests of innovative components

    Energy Technology Data Exchange (ETDEWEB)

    Contalbrigo, M., E-mail: contalbrigo@fe.infn.it [INFN Sezione di Ferrara and University of Ferrara (Italy); Baltzell, N. [Argonne National Laboratory, IL (United States); Benmokhtar, F. [Christopher Newport University, VA (United States); Duquesne University, PA (United States); Barion, L. [INFN Sezione di Ferrara and University of Ferrara (Italy); Cisbani, E. [INFN Sezione di Roma – Gruppo Collega to Sanità (Italy); Italian National Institute of Health (Italy); El Alaoui, A. [Universidad Tecnica Federico Santa Maria, Valparaiso (Chile); Argonne National Laboratory, IL (United States); Hafidi, K. [Argonne National Laboratory, IL (United States); Hoek, M. [Glasgow University (United Kingdom); J. Gutenberg Universität, Mainz (Germany); Kubarovsky, V. [Thomas Jefferson National Laboratory, VA (United States); Lagamba, L. [INFN Sezione di Bari, University of Bari (Italy); Lucherini, V. [INFN Laboratori Nazionali di Frascati (Italy); Malaguti, R. [INFN Sezione di Ferrara and University of Ferrara (Italy); Mirazita, M. [INFN Laboratori Nazionali di Frascati (Italy); Montgomery, R. [Glasgow University (United Kingdom); INFN Laboratori Nazionali di Frascati (Italy); Movsisyan, A. [INFN Sezione di Ferrara and University of Ferrara (Italy); Musico, P. [INFN Sezione di Genova (Italy); Orecchini, D.; Orlandi, A. [INFN Laboratori Nazionali di Frascati (Italy); Pappalardo, L.L. [INFN Sezione di Ferrara and University of Ferrara (Italy); Pereira, S. [INFN Laboratori Nazionali di Frascati (Italy); and others

    2014-12-01

    A large area ring-imaging Cherenkov detector has been designed to provide clean hadron identification capability in the momentum range from 3 GeV/c to 8 GeV/c for the CLAS12 experiments at the upgraded 12 GeV continuous electron beam accelerator facility of Jefferson Lab to study the 3D nucleon structure in the yet poorly explored valence region by deep-inelastic scattering, and to perform precision measurements in hadronization and hadron spectroscopy. The adopted solution foresees a novel hybrid optics design based on an aerogel radiator, composite mirrors and densely packed and highly segmented photon detectors. Cherenkov light will either be imaged directly (forward tracks) or after two mirror reflections (large angle tracks). The preliminary results of individual detector component tests and of the prototype performance at test-beams are reported here. - Highlights: • A novel hybrid-optics configuration was proven to work with a large RICH prototype. • Innovative RICH components were studied both in laboratory tests and test-beams. • Aerogel of large Rayleigh scattering length at n=1.05 was characterized. • Novel vs commercially available multi-anode photomultipliers were compared. • The response of SiPM matrices to Cherenkov light was tested at various temperatures.

  5. ORION: a web server for protein fold recognition and structure prediction using evolutionary hybrid profiles.

    Science.gov (United States)

    Ghouzam, Yassine; Postic, Guillaume; Guerin, Pierre-Edouard; de Brevern, Alexandre G; Gelly, Jean-Christophe

    2016-06-20

    Protein structure prediction based on comparative modeling is the most efficient way to produce structural models when it can be performed. ORION is a dedicated webserver based on a new strategy that performs this task. The identification by ORION of suitable templates is performed using an original profile-profile approach that combines sequence and structure evolution information. Structure evolution information is encoded into profiles using structural features, such as solvent accessibility and local conformation -with Protein Blocks-, which give an accurate description of the local protein structure. ORION has recently been improved, increasing by 5% the quality of its results. The ORION web server accepts a single protein sequence as input and searches homologous protein structures within minutes. Various databases such as PDB, SCOP and HOMSTRAD can be mined to find an appropriate structural template. For the modeling step, a protein 3D structure can be directly obtained from the selected template by MODELLER and displayed with global and local quality model estimation measures. The sequence and the predicted structure of 4 examples from the CAMEO server and a recent CASP11 target from the 'Hard' category (T0818-D1) are shown as pertinent examples. Our web server is accessible at http://www.dsimb.inserm.fr/ORION/.

  6. Summary of results from velocity profile tests and wastage tests in support of LLTR series II test A-4

    International Nuclear Information System (INIS)

    Greene, D.A.

    1981-01-01

    The following conclusions were drawn from the experimental program conducted in support of LLTR (Large Leak Test Rig) Series II Test A-4: Fabrication technique for making precise slits was developed. Wastage boundary agrees with velocity profile boundary. Circumferential slit angles would have to be 120 0 to ensure adequate coverage of adjacent tubes. 120 0 circumferential slit weakens tubes such that maintaining desired slit dimensions for LLTI application is not considered practical. Use of intermittent slit geometry would be required. 120 0 slits, precisely machined and precisely aligned with target tubes, produced different penetration rates on adjacent tubes. Production of simultaneous failures in LLTI with 120 0 slit or simulated interrupted slit is not considered credible

  7. Validity and reliability testing of the Prenatal Psychosocial Profile.

    Science.gov (United States)

    Curry, M A; Campbell, R A; Christian, M

    1994-04-01

    Two studies of low-income pregnant women (N = 179) were done to examine the validity and reliability of the Prenatal Psychosocial Profile (PPP). The PPP, a composite of the Rosenberg Self-Esteem Scale, the Support Behaviors Inventory, and a newly developed measure of stress, is a brief, comprehensive clinical assessment of psychosocial risk during pregnancy. Construct validity of the stress scale was supported by theoretically predicted negative correlations with self-esteem, partner support, and support from others (N = 91). Convergent validity of the stress scale was demonstrated by a correlation of .71 with the Difficult Life Circumstances Scale. Adequate levels of internal consistency were found. Interrelationships between the four subscales were consistent with the underlying conceptualization, and there was beginning evidence of the factorial independence of the subscales.

  8. Towards sustainable urban transportation: Test, demonstration and development of fuel cell and hybrid-electric buses

    International Nuclear Information System (INIS)

    Folkesson, Anders

    2008-05-01

    Several aspects make today's transport system non-sustainable: - Production, transport and combustion of fossil fuels lead to global and local environmental problems. - Oil dependency in the transport sector may lead to economical and political instability. - Air pollution, noise, congestion and land-use may jeopardise public health and quality of life, especially in urban areas. In a sustainable urban transport system most trips are made with public transport because high convenience and comfort makes travelling with public transport attractive. In terms of emissions, including noise, the vehicles are environmentally sustainable, locally as well as globally. Vehicles are energy-efficient and the primary energy stems from renewable sources. Costs are reasonable for all involved, from passengers, bus operators and transport authorities to vehicle manufacturers. The system is thus commercially viable on its own merits. This thesis presents the results from three projects involving different concept buses, all with different powertrains. The first two projects included technical evaluations, including tests, of two different fuel cell buses. The third project focussed on development of a series hybrid-bus with internal combustion engine intended for production around 2010. The research on the fuel cell buses included evaluations of the energy efficiency improvement potential using energy mapping and vehicle simulations. Attitudes to hydrogen fuel cell buses among passengers, bus drivers and bus operators were investigated. Safety aspects of hydrogen as a vehicle fuel were analysed and the use of hydrogen compared to electrical energy storage were also investigated. One main conclusion is that a city bus should be considered as one energy system, because auxiliaries contribute largely to the energy use. Focussing only on the powertrain is not sufficient. The importance of mitigating losses far down an energy conversion chain is emphasised. The Scania hybrid fuel cell

  9. Football helmet drop tests on different fields using an instrumented Hybrid III head.

    Science.gov (United States)

    Viano, David C; Withnall, Chris; Wonnacott, Michael

    2012-01-01

    An instrumented Hybrid III head was placed in a Schutt ION 4D football helmet and dropped on different turfs to study field types and temperature on head responses. The head was dropped 0.91 and 1.83 m giving impacts of 4.2 and 6.0 m/s on nine different football fields (natural, Astroplay, Fieldturf, or Gameday turfs) at turf temperatures of -2.7 to 23.9 °C. Six repeat tests were conducted for each surface at 0.3 m (1') intervals. The Hybrid III was instrumented with triaxial accelerometers to determine head responses for the different playing surfaces. For the 0.91-m drops, peak head acceleration varied from 63.3 to 117.1 g and HIC(15) from 195 to 478 with the different playing surfaces. The lowest response was with Astroplay, followed by the engineered natural turf. Gameday and Fieldturf involved higher responses. The differences between surfaces decreased in the 1.83 m tests. The cold weather testing involved higher accelerations, HIC(15) and delta V for each surface. The helmet drop test used in this study provides a simple and convenient means of evaluating the compliance and energy absorption of football playing surfaces. The type and temperature of the playing surface influence head responses.

  10. Results of KEPCO HTS cable system tests and design of hybrid cryogenic system

    International Nuclear Information System (INIS)

    Lim, J.H.; Sohn, S.H.; Yang, H.S.; Hwang, S.D.; Kim, D.L.; Ryoo, H.S.; Choi, H.O.

    2010-01-01

    In order to investigate the compatibility as a power utility facility, Korea Electric Power Corporation (KEPCO) had installed a 22.9 kV, 1250 A, 100 m long high temperature superconducting (HTS) power cable system. Using the HTS cable, various tests have been performed to investigate electrical and thermo-mechanical properties. Since 2005, a series of thermal cycle tests between liquid nitrogen (LN 2 ) and ambient temperatures have been conducted using a vacuum-pump driven open-loop cryogenic system with a capacity of 3 kW. In the tests, although the open-loop cryogenic system was reliable to operate the HTS cable system, it was not effective in economic view point because LN 2 consumption was larger than expected. In order to secure against unexpected emergencies and solve the problem of LN 2 consumption, a hybrid cryogenic system was designed and installed. A stirling cryocooler was employed and combined with the open-loop cryogenic system. Considering the average heat load at rated condition, the cooling capacity of the cryocooler was determined to 4 kW at 77 K. In this paper, results of performance tests and the design of the hybrid cooling system are presented.

  11. US Department of Energy Hybrid Electric Vehicle Battery and Fuel Economy Testing

    Science.gov (United States)

    Karner, Donald; Francfort, James

    The advanced vehicle testing activity (AVTA), part of the US Department of Energy's FreedomCAR and Vehicle Technologies Program, has conducted testing of advanced technology vehicles since August 1995 in support of the AVTA goal to provide benchmark data for technology modelling, and research and development programs. The AVTA has tested over 200 advanced technology vehicles including full-size electric vehicles, urban electric vehicles, neighborhood electric vehicles, and internal combustion engine vehicles powered by hydrogen. Currently, the AVTA is conducting a significant evaluation of hybrid electric vehicles (HEVs) produced by major automotive manufacturers. The results are posted on the AVTA web page maintained by the Idaho National Laboratory. Through the course of this testing, the fuel economy of HEV fleets has been monitored and analyzed to determine the 'real world' performance of their hybrid energy systems, particularly the battery. The initial fuel economy of these vehicles has typically been less than that determined by the manufacturer and also varies significantly with environmental conditions. Nevertheless, the fuel economy and, therefore, battery performance, has remained stable over the life of a given vehicle (160 000 miles).

  12. Lead-acid batteries in micro-hybrid applications. Part II. Test proposal

    Energy Technology Data Exchange (ETDEWEB)

    Schaeck, S.; Stoermer, A.O. [BMW Group, 80788 Muenchen (Germany); Albers, J. [Johnson Controls Power Solutions EMEA, 30419 Hannover (Germany); Weirather-Koestner, D. [ZSW Ulm, 89081 Ulm (Germany); Kabza, H. [Universitaet Ulm, Institut fuer Energiewandlung und -speicherung, 89081 Ulm (Germany)

    2011-02-01

    In the first part of this work selected key parameters for applying lead-acid (LA) batteries in micro-hybrid power systems (MHPS) were investigated. Main results are integrated in an accelerated, comprehensive test proposal presented here. The test proposal aims at a realistic representation of the pSoC operation regime, which is described in Refs. The test is designed to be sensitive with respect to dynamic charge acceptance (DCA) at partially discharged state (critical for regenerative braking) and the internal resistance at high-rate discharge (critical for idling stop applications). First results are presented for up-to-date valve-regulated LA batteries with absorbent glass mat (AGM) separators. The batteries are close to the limits of the first proposal of pass/fail-criteria. Also flooded batteries were tested; the first out of ten units failed already. (author)

  13. Lead-acid batteries in micro-hybrid applications. Part II. Test proposal

    Science.gov (United States)

    Schaeck, S.; Stoermer, A. O.; Albers, J.; Weirather-Koestner, D.; Kabza, H.

    In the first part of this work [1] selected key parameters for applying lead-acid (LA) batteries in micro-hybrid power systems (MHPS) were investigated. Main results are integrated in an accelerated, comprehensive test proposal presented here. The test proposal aims at a realistic representation of the pSoC operation regime, which is described in Refs. [1,6]. The test is designed to be sensitive with respect to dynamic charge acceptance (DCA) at partially discharged state (critical for regenerative braking) and the internal resistance at high-rate discharge (critical for idling stop applications). First results are presented for up-to-date valve-regulated LA batteries with absorbent glass mat (AGM) separators. The batteries are close to the limits of the first proposal of pass/fail-criteria. Also flooded batteries were tested; the first out of ten units failed already.

  14. Testing and comparison of lidars for profile and turbulence measurements in wind energy

    International Nuclear Information System (INIS)

    Courtney, M; Wagner, R; Lindeloew, P

    2008-01-01

    Lidar profilers are beginning to gain a foothold in wind energy. Both of the currently available commercially systems have been extensively tested at the Hovsore facility in Denmark and valuable insights have been gained. The extensively instrumented facility will be described and some examples of the results given, illustrating the strength and weaknesses of the two contrasting profilers

  15. Dish/Stirling Hybrid-Receiver Sub-Scale Tests and Full-Scale Design

    International Nuclear Information System (INIS)

    Andraka, Charles; Bohn, Mark S.; Corey, John; Mehos, Mark; Moreno, James; Rawlinson, Scott

    1999-01-01

    We have designed and tested a prototype dish/Stirling hybrid-receiver combustion system. The system consists of a pre-mixed natural-gas burner heating a pin-finned sodium heat pipe. The design emphasizes simplicity, low cost, and ruggedness. Our test was on a 1/6 th -scale device, with a nominal firing rate of 18kWt, a power throughput of 13kWt, and a sodium vapor temperature of 750 ampersand deg;C. The air/fuel mixture was electrically preheated to 640 ampersand deg;C to simulate recuperation. The test rig was instrumented for temperatures, pressures, flow rates, overall leak rate, and exhaust emissions. The data verify our burner and heat-transfer models. Performance and post-test examinations validate our choice of materials and fabrication methods. Based on the 1/6 th -scale results, we are designing a till-scale hybrid receiver. This is a fully-integrated system, including burner, pin-fin primary heat exchanger, recuperator (in place of the electrical pre-heater used in the prototype system), solar absorber, and sodium heat pipe. The major challenges of the design are to avoid pre-ignition, achieve robust heat-pipe performance, and attain long life of the burner matrix, recuperator, and flue-gas seals. We have used computational fluid dynamics extensively in designing to avoid pre-ignition and for designing the heat-pipe wick, and we have used individual component tests and results of the 1/6 th -scale test to optimize for long life. In this paper, we present our design philosophy and basic details of our design. We describe the sub-scale test rig and compare test results with predictions. Finally, we outline the evolution of our full-scale design, and present its current status

  16. Streptococcus pneumoniae Supragenome Hybridization Arrays for Profiling of Genetic Content and Gene Expression.

    Science.gov (United States)

    Kadam, Anagha; Janto, Benjamin; Eutsey, Rory; Earl, Joshua P; Powell, Evan; Dahlgren, Margaret E; Hu, Fen Z; Ehrlich, Garth D; Hiller, N Luisa

    2015-02-02

    There is extensive genomic diversity among Streptococcus pneumoniae isolates. Approximately half of the comprehensive set of genes in the species (the supragenome or pangenome) is present in all the isolates (core set), and the remaining is unevenly distributed among strains (distributed set). The Streptococcus pneumoniae Supragenome Hybridization (SpSGH) array provides coverage for an extensive set of genes and polymorphisms encountered within this species, capturing this genomic diversity. Further, the capture is quantitative. In this manner, the SpSGH array allows for both genomic and transcriptomic analyses of diverse S. pneumoniae isolates on a single platform. In this unit, we present the SpSGH array, and describe in detail its design and implementation for both genomic and transcriptomic analyses. The methodology can be applied to construction and modification of SpSGH array platforms, as well to other bacterial species as long as multiple whole-genome sequences are available that collectively capture the vast majority of the species supragenome. Copyright © 2015 John Wiley & Sons, Inc.

  17. Mechanistic profiling of the siRNA delivery dynamics of lipid-polymer hybrid nanoparticles.

    Science.gov (United States)

    Colombo, Stefano; Cun, Dongmei; Remaut, Katrien; Bunker, Matt; Zhang, Jianxin; Martin-Bertelsen, Birte; Yaghmur, Anan; Braeckmans, Kevin; Nielsen, Hanne M; Foged, Camilla

    2015-03-10

    Understanding the delivery dynamics of nucleic acid nanocarriers is fundamental to improve their design for therapeutic applications. We investigated the carrier structure-function relationship of lipid-polymer hybrid nanoparticles (LPNs) consisting of poly(DL-lactic-co-glycolic acid) (PLGA) nanocarriers modified with the cationic lipid dioleoyltrimethyl-ammoniumpropane (DOTAP). A library of siRNA-loaded LPNs was prepared by systematically varying the nitrogen-to-phosphate (N/P) ratio. Atomic force microscopy (AFM) and cryo-transmission electron microscopy (cryo-TEM) combined with small angle X-ray scattering (SAXS) and confocal laser scanning microscopy (CLSM) studies suggested that the siRNA-loaded LPNs are characterized by a core-shell structure consisting of a PLGA matrix core coated with lamellar DOTAP structures with siRNA localized both in the core and in the shell. Release studies in buffer and serum-containing medium combined with in vitro gene silencing and quantification of intracellular siRNA suggested that this self-assembling core-shell structure influences the siRNA release kinetics and the delivery dynamics. A main delivery mechanism appears to be mediated via the release of transfection-competent siRNA-DOTAP lipoplexes from the LPNs. Based on these results, we suggest a model for the nanostructural characteristics of the LPNs, in which the siRNA is organized in lamellar superficial assemblies and/or as complexes entrapped in the polymeric matrix. Copyright © 2015 Elsevier B.V. All rights reserved.

  18. Influence of the magnetic field profile on ITER conductor testing

    International Nuclear Information System (INIS)

    Nijhuis, A; Ilyin, Y; Kate, H H J ten

    2006-01-01

    We performed simulations with the numerical CUDI-CICC code on a typical short ITER (International Thermonuclear Experimental Reactor) conductor test sample of dual leg configuration, as usually tested in the SULTAN test facility, and made a comparison with the new EFDA-Dipole test facility offering a larger applied DC field region. The new EFDA-Dipole test facility, designed for short sample testing of conductors for ITER, has a homogeneous high field region of 1.2 m, while in the SULTAN facility this region is three times shorter. The inevitable non-uniformity of the current distribution in the cable, introduced by the joints at both ends, has a degrading effect on voltage-current (VI) and voltage-temperature (VT) characteristics, particularly for these short samples. This can easily result in an underestimation or overestimation of the actual conductor performance. A longer applied DC high field region along a conductor suppresses the current non-uniformity by increasing the overall longitudinal cable electric field when reaching the current sharing mode. The numerical interpretation study presented here gives a quantitative analysis for a relevant practical case of a test of a short sample poloidal field coil insert (PFCI) conductor in SULTAN. The simulation includes the results of current distribution analysis from self-field measurements with Hall sensor arrays, current sharing measurements and inter-petal resistance measurements. The outcome of the simulations confirms that the current uniformity improves with a longer high field region but the 'measured' VI transition is barely affected, though the local peak voltages become somewhat suppressed. It appears that the location of the high field region and voltage taps has practically no influence on the VI curve as long as the transverse voltage components are adequately cancelled. In particular, for a thin conduit wall, the voltage taps should be connected to the conduit in the form of an (open) azimuthally

  19. Global transcriptome profiling analysis of inhibitory effects of paclobutrazol on leaf growth in lily (Lilium Longiflorum-Asiatic hybrid

    Directory of Open Access Journals (Sweden)

    Xiaopei eZhu

    2016-04-01

    Full Text Available As a popular ornamental flower, potted lily is an important object of lily breeding. Paclobutrazol, a chemical growth retardation compound, is often used to dwarf plant in producing potted lilies. However, in recent years, the plants with inherited dwarf traits by using genetic engineer breeding technology are being developed. The studies on molecular basis of lily dwarfism will offer some target genes which have profound dwarf effect for genetic engineer breeding. Here, we confirmed that paclobutrazol inhibited plant height and leaf size in Lilium Longiflorum-Asiatic hybrid, and then RNA-Seq technique was employed to analyze gene transcripts of Lilium Longiflorum-Asiatic hybrid leaves by paclobutrazol treatment in order to get a deeper insight into dwarfism mechanism of lily. Approximately 38.6 Gb data was obtained and assemble into 53,681 unigenes. Annotation, pathways, functional classification and phylogenetic classification of these data were analyzed based on Nr, Nt, Swiss-Prot, KEGG, COG and GO databases. 2,704 differentially expressed genes were screened by comparing paclobutrazol-treated samples with untreated samples and quantitative real-time PCR was performed to validate expression profiles. By analyzing dynamic changes of differentially expressed genes, nine metabolic pathways and signal transduction pathways were significantly enriched and many potentially interesting genes were identified that encoded putative regulators or key components of cell division, cell expansion, GA metabolism and signaling transduction and these genes were highlighted to reveal their importance in regulation of plant size. These results will provide a better understanding of the molecular mechanism on lily dwarfism and some potential genes related to lily organ size, which will lay the foundation for molecular breeding of potted lilies. These transcriptome data will also serve as valuable public genomic resources for other genetic research in lily.

  20. Helminths and skewed cytokine profiles increase tuberculin skin test positivity in Warao Amerindians

    NARCIS (Netherlands)

    Verhagen, L. M.; Hermans, P. W. M.; Warris, A.; de Groot, R.; Maes, M.; Villalba, J. A.; del Nogal, B.; van den Hof, S.; Mughini Gras, L.; van Soolingen, D.; Pinelli, E.; de Waard, J. H.

    2012-01-01

    The immune regulatory mechanisms involved in the acquisition of Mycobacterium tuberculosis infection in children are largely unknown. We investigated the influence of parasitic infections, malnutrition and plasma cytokine profiles on tuberculin skin test (TST) positivity in Warao Amerindians in

  1. Theoretical fringe profiles with crossed Babinet compensators in testing concave aspheric surfaces.

    Science.gov (United States)

    Saxena, A K; Lancelot, J P

    1982-11-15

    This paper presents the theory for the use of crossed Babinet compensators in testing concave aspheric surfaces. Theoretical fringe profiles for a sphere and for an aspheric surface with primary aberration are shown. Advantages of this method are discussed.

  2. Demonstration and field trial of a resilient hybrid NG-PON test-bed

    Science.gov (United States)

    Prat, Josep; Polo, Victor; Schrenk, Bernhard; Lazaro, Jose A.; Bonada, Francesc; Lopez, Eduardo T.; Omella, Mireia; Saliou, Fabienne; Le, Quang T.; Chanclou, Philippe; Leino, Dmitri; Soila, Risto; Spirou, Spiros; Costa, Liliana; Teixeira, Antonio; Tosi-Beleffi, Giorgio M.; Klonidis, Dimitrios; Tomkos, Ioannis

    2014-10-01

    A multi-layer next generation PON prototype has been built and tested, to show the feasibility of extended hybrid DWDM/TDM-XGPON FTTH networks with resilient optically-integrated ring-trees architecture, supporting broadband multimedia services. It constitutes a transparent common platform for the coexistence of multiple operators sharing the optical infrastructure of the central metro ring, passively combining the access and the metropolitan network sections. It features 32 wavelength connections at 10 Gbps, up to 1000 users distributed in 16 independent resilient sub-PONs over 100 km. This paper summarizes the network operation, demonstration and field trial results.

  3. Proficiency testing for sensory profile panels : measuring panel performance

    NARCIS (Netherlands)

    Mcewan, J.A.; Hunter, E.A.; Gemert, L.J. van; Lea, P.

    2002-01-01

    Proficiency testing in sensory analysis is an important step towards demonstrating that results from one sensory panel are consistent with the results of other sensory panels. The uniqueness of sensory analysis poses some specific problems for measuring the proficiency of the human instrument

  4. Plutonium, americium, and uranium concentrations in Nevada Test Site soil profiles

    International Nuclear Information System (INIS)

    Essington, E.H.; Gilbert, R.O.; Eberhardt, L.L.; Fowler, E.B.

    1975-01-01

    Many soil profile samples were collected by the Nevada Applied Ecology Group from five nuclear safety test sites on the Nevada Test Site and Tonopah Test Range in Nevada, U.S.A. The profile samples were analyzed for 239 Pu, 240 Pu, 241 Am, and in some cases 235 U and 238 U, in order to estimate the depth of radionuclide penetration and level of contamination at specific sampling depths after an extended period of time since deposition on the surface. Nearly 70 individual profiles were examined. About one-half of the profiles exhibited a smooth leaching pattern with more than 95 percent of the plutonium in the top 5 cm. Other profile patterns are discussed relative to mechanical disturbance of the profile after the initial deposition, accumulation of plutonium in specific zones within the soil profile, and occurrence of large amounts of plutonium in the deepest parts of the soil profile. The implications of these observations are discussed with respect to redistribution of radioactivity by wind, water, and burrowing animals, ingestion by burrowing and grazing animals, uptake by vegetation, and cleanup operations. (auth)

  5. A comprehensive hybridization model allows whole HERV transcriptome profiling using high density microarray.

    Science.gov (United States)

    Becker, Jérémie; Pérot, Philippe; Cheynet, Valérie; Oriol, Guy; Mugnier, Nathalie; Mommert, Marine; Tabone, Olivier; Textoris, Julien; Veyrieras, Jean-Baptiste; Mallet, François

    2017-04-08

    Human endogenous retroviruses (HERVs) have received much attention for their implications in the etiology of many human diseases and their profound effect on evolution. Notably, recent studies have highlighted associations between HERVs expression and cancers (Yu et al., Int J Mol Med 32, 2013), autoimmunity (Balada et al., Int Rev Immunol 29:351-370, 2010) and neurological (Christensen, J Neuroimmune Pharmacol 5:326-335, 2010) conditions. Their repetitive nature makes their study particularly challenging, where expression studies have largely focused on individual loci (De Parseval et al., J Virol 77:10414-10422, 2003) or general trends within families (Forsman et al., J Virol Methods 129:16-30, 2005; Seifarth et al., J Virol 79:341-352, 2005; Pichon et al., Nucleic Acids Res 34:e46, 2006). To refine our understanding of HERVs activity, we introduce here a new microarray, HERV-V3. This work was made possible by the careful detection and annotation of genomic HERV/MaLR sequences as well as the development of a new hybridization model, allowing the optimization of probe performances and the control of cross-reactions. RESULTS: HERV-V3 offers an almost complete coverage of HERVs and their ancestors (mammalian apparent LTR-retrotransposons, MaLRs) at the locus level along with four other repertoires (active LINE-1 elements, lncRNA, a selection of 1559 human genes and common infectious viruses). We demonstrate that HERV-V3 analytical performances are comparable with commercial Affymetrix arrays, and that for a selection of tissue/pathological specific loci, the patterns of expression measured on HERV-V3 is consistent with those reported in the literature. Given its large HERVs/MaLRs coverage and additional repertoires, HERV-V3 opens the door to multiple applications such as enhancers and alternative promoters identification, biomarkers identification as well as the characterization of genes and HERVs/MaLRs modulation caused by viral infection.

  6. Suppression subtractive hybridization reveals transcript profiling of Chlorella under heterotrophy to photoautotrophy transition.

    Directory of Open Access Journals (Sweden)

    Jianhua Fan

    Full Text Available Microalgae have been extensively investigated and exploited because of their competitive nutritive bioproducts and biofuel production ability. Chlorella are green algae that can grow well heterotrophically and photoautotrophically. Previous studies proved that shifting from heterotrophy to photoautotrophy in light-induced environments causes photooxidative damage as well as distinct physiologic features that lead to dynamic changes in Chlorella intracellular components, which have great potential in algal health food and biofuel production. However, the molecular mechanisms underlying the trophic transition remain unclear.In this study, suppression subtractive hybridization strategy was employed to screen and characterize genes that are differentially expressed in response to the light-induced shift from heterotrophy to photoautotrophy. Expressed sequence tags (ESTs were obtained from 770 and 803 randomly selected clones among the forward and reverse libraries, respectively. Sequence analysis identified 544 unique genes in the two libraries. The functional annotation of the assembled unigenes demonstrated that 164 (63.1% from the forward library and 62 (21.8% from the reverse showed significant similarities with the sequences in the NCBI non-redundant database. The time-course expression patterns of 38 selected differentially expressed genes further confirmed their responsiveness to a diverse trophic status. The majority of the genes enriched in the subtracted libraries were associated with energy metabolism, amino acid metabolism, protein synthesis, carbohydrate metabolism, and stress defense.The data presented here offer the first insights into the molecular foundation underlying the diverse microalgal trophic niche. In addition, the results can be used as a reference for unraveling candidate genes associated with the transition of Chlorella from heterotrophy to photoautotrophy, which holds great potential for further improving its lipid and

  7. Image processing and computer controls for video profile diagnostic system in the ground test accelerator (GTA)

    International Nuclear Information System (INIS)

    Wright, R.; Zander, M.; Brown, S.; Sandoval, D.; Gilpatrick, D.; Gibson, H.

    1992-01-01

    This paper describes the application of video image processing to beam profile measurements on the Ground Test Accelerator (GTA). A diagnostic was needed to measure beam profiles in the intermediate matching section (IMS) between the radio-frequency quadrupole (RFQ) and the drift tube linac (DTL). Beam profiles are measured by injecting puffs of gas into the beam. The light emitted from the beam-gas interaction is captured and processed by a video image processing system, generating the beam profile data. A general purpose, modular and flexible video image processing system, imagetool, was used for the GTA image profile measurement. The development of both software and hardware for imagetool and its integration with the GTA control system (GTACS) is discussed. The software includes specialized algorithms for analyzing data and calibrating the system. The underlying design philosophy of imagetool was tested by the experience of building and using the system, pointing the way for future improvements. (Author) (3 figs., 4 refs.)

  8. Hybrid composite laminates reinforced with Kevlar/carbon/glass woven fabrics for ballistic impact testing.

    Science.gov (United States)

    Randjbaran, Elias; Zahari, Rizal; Jalil, Nawal Aswan Abdul; Majid, Dayang Laila Abang Abdul

    2014-01-01

    Current study reported a facile method to investigate the effects of stacking sequence layers of hybrid composite materials on ballistic energy absorption by running the ballistic test at the high velocity ballistic impact conditions. The velocity and absorbed energy were accordingly calculated as well. The specimens were fabricated from Kevlar, carbon, and glass woven fabrics and resin and were experimentally investigated under impact conditions. All the specimens possessed equal mass, shape, and density; nevertheless, the layers were ordered in different stacking sequence. After running the ballistic test at the same conditions, the final velocities of the cylindrical AISI 4340 Steel pellet showed how much energy was absorbed by the samples. The energy absorption of each sample through the ballistic impact was calculated; accordingly, the proper ballistic impact resistance materials could be found by conducting the test. This paper can be further studied in order to characterise the material properties for the different layers.

  9. Hybrid Composite Laminates Reinforced with Kevlar/Carbon/Glass Woven Fabrics for Ballistic Impact Testing

    Directory of Open Access Journals (Sweden)

    Elias Randjbaran

    2014-01-01

    Full Text Available Current study reported a facile method to investigate the effects of stacking sequence layers of hybrid composite materials on ballistic energy absorption by running the ballistic test at the high velocity ballistic impact conditions. The velocity and absorbed energy were accordingly calculated as well. The specimens were fabricated from Kevlar, carbon, and glass woven fabrics and resin and were experimentally investigated under impact conditions. All the specimens possessed equal mass, shape, and density; nevertheless, the layers were ordered in different stacking sequence. After running the ballistic test at the same conditions, the final velocities of the cylindrical AISI 4340 Steel pellet showed how much energy was absorbed by the samples. The energy absorption of each sample through the ballistic impact was calculated; accordingly, the proper ballistic impact resistance materials could be found by conducting the test. This paper can be further studied in order to characterise the material properties for the different layers.

  10. Manufacturing experience and test results of the PS prototype flexible hybrid circuit for the CMS Tracker Upgrade

    CERN Document Server

    Kovacs, Mark Istvan; Gadek, Tomasz; Honma, Alan; Vasey, Francois

    2017-01-01

    The CMS Tracker Phase-2 Upgrade for HL-LHC requires High Density Interconnect (HDI) flexible hybrid circuits to build modules with low mass and high granularity. The hybrids are carbon fibre reinforced flexible circuits with flip-chips and passives. Three different manufacturers produced prototype hybrids for the Pixel-Strip type modules. The first part of the presentation will focus on the design challenges of this state of the art circuit. Afterwards, the difficulties and experience related to the circuit manufacturing and assembly are presented. The description of quality inspection methods with comprehensive test results will lead to the conclusion.

  11. PROFILE OF HEMATOCRIT LEVEL CAPTURED BY DIGITAL HEMATOCRIT TEST

    Directory of Open Access Journals (Sweden)

    Prihartini Widiyanti

    2015-09-01

    Full Text Available The dengue fever is a disease caused by Dengue virus which is transmitted via Aedes aegypti and Aedes albopictus vector. This Dengue Haemorrhagic Fever (DHF case in Indonesia tend to rise from year to year caused by delayed detection and inadequate handling. The laboratory parameter of hematocrite had regularly been performed using invasive method by taking the blood from the patient. This method is still not been able to monitor patients with DHF by repetitive and accurate measurament. This research project aims is to perform a digital hematocrit test (DHT with non-invasive accurate sensors. Digital Hematocrit Test (DHT is needed to presenting fast, exact, economical and accurate detection methods of hematocrit level. Measureable magnitude by the instrumentation is non-absorb intensity electromagnetic waves 560 nm emitted by transmitter captured by receiver. Signal captured by the receiver then converted into electrical signal. The electrical signal from receiver was the levels of hemoglobin. Levels of hemoglobin then converted to hematocrit. Hematokrit is three times the level of hemoglobin. Technology of hematocrit monitoring is aimed to control DHF patient clinical symptoms continuously and acquisitively.

  12. Profiles

    International Nuclear Information System (INIS)

    2004-01-01

    Profiles is a synthetic overview of more than 100 national energy markets in the world, providing insightful facts and key energy statistics. A Profile is structured around 6 main items and completed by key statistics: Ministries, public agencies, energy policy are concerned; main companies in the oil, gas, electricity and coal sectors, status, shareholders; reserve, production, imports and exports, electricity and refining capacities; deregulation of prices, subsidies, taxes; consumption trends by sector, energy market shares; main energy projects, production and consumption prospects. Statistical Profiles are present in about 3 pages the main data and indicators on oil, gas, coal and electricity. (A.L.B.)

  13. Preliminary test of an imaging probe for nuclear medicine using hybrid pixel detectors

    International Nuclear Information System (INIS)

    Bertolucci, E.; Maiorino, M.; Mettivier, G.; Montesi, M.C.; Russo, P.

    2002-01-01

    We are investigating the feasibility of an intraoperative imaging probe for lymphoscintigraphy with Tc-99m tracer, for sentinel node radioguided surgery, using the Medipix series of hybrid detectors coupled to a collimator. These detectors are pixelated semiconductor detectors bump-bonded to the Medipix1 photon counting read-out chip (64x64 pixel, 170 μm pitch) or to the Medipix2 chip (256x256 pixel, 55 μm pitch), developed by the European Medipix collaboration. The pixel detector we plan to use in the final version of the probe is a semi-insulating GaAs detector or a 1-2 mm thick CdZnTe detector. For the preliminary tests presented here, we used 300-μm thick silicon detectors, hybridized via bump-bonding to the Medipix1 chip. We used a tungsten parallel-hole collimator (7 mm thick, matrix array of 64x64 100 μm circular holes with 170 μm pitch), and a 22, 60 and 122 keV point-like (1 mm diameter) radioactive sources, placed at various distances from the detector. These tests were conducted in order to investigate the general feasibility of this imaging probe and its resolving power. Measurements show the high resolution but low efficiency performance of the detector-collimator set, which is able to image the 122 keV source with <1 mm FWHM resolution

  14. Biomechanical testing of a hybrid locking plate fixation of equine sesamoid osteotomies.

    Science.gov (United States)

    Almeida da Silveira, E; Levasseur, A; Lacourt, M; Elce, Y; Petit, Y

    2014-01-01

    To compare the biomechanical properties of a hybrid locking compression plate (LCP) construct with the compression screw technique as a treatment for transverse mid-body proximal sesamoid bone fractures. Ten paired forelimbs from abattoir horses were used. The medial proximal sesamoid bone of each limb was osteotomized transversely and randomly assigned, to either repair with a two-hole 3.5 mm LCP or a 4.5 mm cortical screw placed in lag fashion. Each limb was tested biomechanically by axial loading in single cycle until failure. The point of failure was evaluated from the load-displacement curves. Then a gross evaluation and radiographs were performed to identify the mode of failure. The loads to failure of limbs repaired with the hybrid LCP construct (4968 N ± 2167) and the limbs repaired with the screw technique (3009 N ± 1091) were significantly different (p fracture of the apical fragment of the proximal sesamoid bone. The LCP technique has potential to achieve a better fracture stability and healing when applied to mid-body fractures of the proximal sesamoid bone. Further testing, particularly fatigue resistance is required to corroborate its potential as a treatment option for mid-body fractures of the proximal sesamoid bone.

  15. CGI: Java software for mapping and visualizing data from array-based comparative genomic hybridization and expression profiling.

    Science.gov (United States)

    Gu, Joyce Xiuweu-Xu; Wei, Michael Yang; Rao, Pulivarthi H; Lau, Ching C; Behl, Sanjiv; Man, Tsz-Kwong

    2007-10-06

    With the increasing application of various genomic technologies in biomedical research, there is a need to integrate these data to correlate candidate genes/regions that are identified by different genomic platforms. Although there are tools that can analyze data from individual platforms, essential software for integration of genomic data is still lacking. Here, we present a novel Java-based program called CGI (Cytogenetics-Genomics Integrator) that matches the BAC clones from array-based comparative genomic hybridization (aCGH) to genes from RNA expression profiling datasets. The matching is computed via a fast, backend MySQL database containing UCSC Genome Browser annotations. This program also provides an easy-to-use graphical user interface for visualizing and summarizing the correlation of DNA copy number changes and RNA expression patterns from a set of experiments. In addition, CGI uses a Java applet to display the copy number values of a specific BAC clone in aCGH experiments side by side with the expression levels of genes that are mapped back to that BAC clone from the microarray experiments. The CGI program is built on top of extensible, reusable graphic components specifically designed for biologists. It is cross-platform compatible and the source code is freely available under the General Public License.

  16. CGI: Java Software for Mapping and Visualizing Data from Array-based Comparative Genomic Hybridization and Expression Profiling

    Directory of Open Access Journals (Sweden)

    Joyce Xiuweu-Xu Gu

    2007-01-01

    Full Text Available With the increasing application of various genomic technologies in biomedical research, there is a need to integrate these data to correlate candidate genes/regions that are identified by different genomic platforms. Although there are tools that can analyze data from individual platforms, essential software for integration of genomic data is still lacking. Here, we present a novel Java-based program called CGI (Cytogenetics-Genomics Integrator that matches the BAC clones from array-based comparative genomic hybridization (aCGH to genes from RNA expression profiling datasets. The matching is computed via a fast, backend MySQL database containing UCSC Genome Browser annotations. This program also provides an easy-to-use graphical user interface for visualizing and summarizing the correlation of DNA copy number changes and RNA expression patterns from a set of experiments. In addition, CGI uses a Java applet to display the copy number values of a specifi c BAC clone in aCGH experiments side by side with the expression levels of genes that are mapped back to that BAC clone from the microarray experiments. The CGI program is built on top of extensible, reusable graphic components specifically designed for biologists. It is cross-platform compatible and the source code is freely available under the General Public License.

  17. Geology along topographic profile for near-surface test facility

    International Nuclear Information System (INIS)

    Fecht, K.R.

    1978-01-01

    The U.S. Department of Energy, through the Basalt Waste Isolation Program within Rockwell Hanford Operations, is investigating the feasibility of terminal storage of radioactive waste in deep caverns constructed in the Columbia River Basalt. A portion of the geological work conducted in support of the Engineering Design Unit to evaluate the west end of Gable Mountain as a site for in situ testing of the thermomechanical behavior of basalt is reported. The surficial geology of the west end of Gable Mountain was mapped in a reconnaissance fashion at a scale of 1:62,500 to identify geologic features which could affect siting of the proposed facilities. A detailed study of the geological conditions was conducted along a traverse across the most probable site for the proposed project

  18. Geographically distributed hybrid testing & collaboration between geotechnical centrifuge and structures laboratories

    Science.gov (United States)

    Ojaghi, Mobin; Martínez, Ignacio Lamata; Dietz, Matt S.; Williams, Martin S.; Blakeborough, Anthony; Crewe, Adam J.; Taylor, Colin A.; Madabhushi, S. P. Gopal; Haigh, Stuart K.

    2018-01-01

    Distributed Hybrid Testing (DHT) is an experimental technique designed to capitalise on advances in modern networking infrastructure to overcome traditional laboratory capacity limitations. By coupling the heterogeneous test apparatus and computational resources of geographically distributed laboratories, DHT provides the means to take on complex, multi-disciplinary challenges with new forms of communication and collaboration. To introduce the opportunity and practicability afforded by DHT, here an exemplar multi-site test is addressed in which a dedicated fibre network and suite of custom software is used to connect the geotechnical centrifuge at the University of Cambridge with a variety of structural dynamics loading apparatus at the University of Oxford and the University of Bristol. While centrifuge time-scaling prevents real-time rates of loading in this test, such experiments may be used to gain valuable insights into physical phenomena, test procedure and accuracy. These and other related experiments have led to the development of the real-time DHT technique and the creation of a flexible framework that aims to facilitate future distributed tests within the UK and beyond. As a further example, a real-time DHT experiment between structural labs using this framework for testing across the Internet is also presented.

  19. Design and RF test result of High Power Hybrid Combiner for Helicon Wave Current Drive in KSTAR Plasmas

    Energy Technology Data Exchange (ETDEWEB)

    Park, S. Y.; Kim, H. J.; Wi, H. H.; Wang, S. J.; Kwak, J. G. [NFRI, Daejeon (Korea, Republic of)

    2016-05-15

    200 kW RF power will be injected to plasmas through the traveling wave antenna after combining four klystrons output powers using three hybrid combiners. Each klystron produces 60 kW output at the frequency of 500 MHz. RF power combiners commonly used to divide or combine output powers for various rf and microwave applications. It is divided into several types according to the design type such as Wilkinson combiner, radial and quadrature hybrid combiner. We designed high power hybrid combiners using 6-1/8 inch coaxial line. The power combiner has many advantages such as high isolation, low insertion loss and high power handling capability. In this paper design and rf test results of high power combiners will be described. High power combiners using three coaxial hybrid couplers will be utilized for effectively combining of 500 MHz, 200 kW output powers generated by four klystrons. We have designed, fabricated, and tested a 6-1/8 inch coaxial hybrid combiners at 500 MHz for efficiently off-axis Helicon wave current drive in KSTAR. Simulation and test results of high power coaxial hybrid combiners are good agreement.

  20. Reproductive endocrine profiles and follicular growth after estrus induction in the riverine water buffalo (Bubalus bubalis, 2n=50 and riverine-swamp hybrid buffalo (2n = 49

    Directory of Open Access Journals (Sweden)

    R.H. BonDurant

    2010-02-01

    Full Text Available Ten adult female water buffalo were used in the present study (5 x [2n = 50] and 5 x [2n= 49] hybrids. Ovarian activity was monitored daily by transrectal ultrasonography between two consecutive ovulations. Observed follicular wave numbers were: 1 (n=1, 2 (n=4, and 3 (n=5. The interovulatory interval ranged 17 to 23 days. Differences in mean follicular diameter between follicles of the normal karyotype (2n=50 and buffalo hybrids (2n=49 were found on the second subordinate group of follicles (P0.05, whereas inhibin profiles were significantly higher in the hybrid group (P<0.05. Understanding the biological meaning of the difference in inhibin concentrations in B. bubalis female reproductive performance will require further investigation.

  1. Performance of Small Bore 60NiTi Hybrid Ball Bearings: Preliminary Life Test Results

    Science.gov (United States)

    Dellacorte, Christopher; Howard, S. Adam

    2016-01-01

    Small bore (R8 size) hybrid ball bearings made with 60NiTi races and silicon nitride balls are under development for highly corrosive aerospace applications that are also exposed to heavy static (shock) loads. The target application is the vacuum pump used inside the wastewater recycling system on the International Space Station. To verify bearing longevity, life tests are run at 2000rpm for time periods up to 5000 hours. Accelerometers with data tracking are used to monitor operation and the bearings are disassembled and inspected at intervals to assess wear. Preliminary tests show that bearings made from 60NiTi are feasible for this aerospace and potentially other industrial applications that must endure similar operating environments.

  2. High RF power test of a lower hybrid module mock-up in carbon fiber composite

    International Nuclear Information System (INIS)

    Goniche, M.; Bibet, P.; Brossaud, J.; Cano, V.; Froissard, P.; Kazarian, F.; Rey, G.; Maebara, S.; Kiyono, K.; Seki, M.; Suganuma, K.; Ikeda, Y.; Imai, T.

    1999-02-01

    A mock-up module of a Lower Hybrid Current Drive antenna module of a Carbon Fiber Composite (CFC) was fabricated for the development of heat resistive front facing the plasma. This module is made from CFC plates and rods which are copper coated to reduce the RF losses. The withstand-voltage, the RF properties and outgassing rates for long pulses and high RF power were tested at the Lower Hybrid test bed facility of Cadarache. After the short pulse conditioning, long pulses with a power density ranging between 50 and 150 MW/m 2 were performed with no breakdowns. During these tests, the module temperature was increasing from 100-200 deg. C to 400-500 deg. C. It was also checked that high power density, up to 150 MW/m 2 , could be transmitted when the waveguides are filled with H 2 at a pressure of 5 x 10 -2 Pa. No significant change in the reflection coefficient is measured after the long pulse operation. During a long pulse, the power reflection increases during the pulse typically from 0.8% to 1.3%. It is concluded that the outgassing rate of Cu-plated CFC is about 6 times larger than of Dispersion Strengthened Copper (DSC) module at the module temperature of 300 deg. C. No significant increase of the global outgassing of the CFC module was measured after hydrogen pre-filling. After the test, visual inspection revealed that peeling of the copper coating occurred at one end of the module only on a very small area (0.2 cm 2 ). It is assessed that a CFC module is an attractive candidate for the hardening of the tip of the LHCD antenna. (authors)

  3. High RF power test of a lower hybrid module mock-up in Carbon Fiber Composite

    International Nuclear Information System (INIS)

    Maebara, Sunao; Kiyono, Kimihiro; Seki, Masami

    1997-11-01

    A mock-up module of a Lower Hybrid Current Drive antenna module of a Carbon Fiber Composite (CFC) was fabricated for the development of heat resistive front facing the plasma. This module is made from CFC plates and rods which are copper coated to reduce the RF losses. The withstand-voltage, the RF properties and outgassing rates for long pulses and high RF power were tested at the Lower Hybrid test bed facility of Cadarache. After the short pulse conditioning, long pulses with a power density ranging between 50 and 150 MW/m 2 were performed with no breakdowns. During these tests, the module temperature was increasing from 100-200degC to 400-500degC. It was also checked that high power density, up to 150 MW/m 2 , could be transmitted when the waveguides are filled with H 2 at a pressure of 5 x 10 -2 Pa. No significant change in the reflection coefficient is measured after the long pulse operation. During a long pulse, the power reflection increases during the pulse typically from 0.8 % to 1.3 %. It is concluded that the outgassing rate of Cu-plated CFC is about 6-7 times larger than of Dispersion Strengthened Copper (DSC) module at the module temperature of 300degC. No significant increase of the global outgassing of the CFC module was measured after hydrogen prefilling. After the test, visual inspection revealed that peeling of the copper coating occurred at one end of the module only on a very small area (0.2 cm 2 ). It is assessed that a CFC module is an attractive candidate for the hardening of the tip of the LHCD antenna. (author)

  4. Model-based framework for multi-axial real-time hybrid simulation testing

    Science.gov (United States)

    Fermandois, Gaston A.; Spencer, Billie F.

    2017-10-01

    Real-time hybrid simulation is an efficient and cost-effective dynamic testing technique for performance evaluation of structural systems subjected to earthquake loading with rate-dependent behavior. A loading assembly with multiple actuators is required to impose realistic boundary conditions on physical specimens. However, such a testing system is expected to exhibit significant dynamic coupling of the actuators and suffer from time lags that are associated with the dynamics of the servo-hydraulic system, as well as control-structure interaction (CSI). One approach to reducing experimental errors considers a multi-input, multi-output (MIMO) controller design, yielding accurate reference tracking and noise rejection. In this paper, a framework for multi-axial real-time hybrid simulation (maRTHS) testing is presented. The methodology employs a real-time feedback-feedforward controller for multiple actuators commanded in Cartesian coordinates. Kinematic transformations between actuator space and Cartesian space are derived for all six-degrees-offreedom of the moving platform. Then, a frequency domain identification technique is used to develop an accurate MIMO transfer function of the system. Further, a Cartesian-domain model-based feedforward-feedback controller is implemented for time lag compensation and to increase the robustness of the reference tracking for given model uncertainty. The framework is implemented using the 1/5th-scale Load and Boundary Condition Box (LBCB) located at the University of Illinois at Urbana- Champaign. To demonstrate the efficacy of the proposed methodology, a single-story frame subjected to earthquake loading is tested. One of the columns in the frame is represented physically in the laboratory as a cantilevered steel column. For realtime execution, the numerical substructure, kinematic transformations, and controllers are implemented on a digital signal processor. Results show excellent performance of the maRTHS framework when six

  5. Performance test of lower hybrid waveguide under long/high-RF power transmission

    International Nuclear Information System (INIS)

    Seki, Masami; Obara, Kenjiro; Maebara, Sunao

    1996-06-01

    Performance tests of a module for lower hybrid waveguides were carried out at the CEA Cadarache RF Test Facility. For the experiments the test module was fabricated by JAERI, the transmission line of the test bed was modified and the connection waveguides were manufactured by CEA. As the results, the thermal treatment by baking at a higher temperature was the most effective for reducing outgassing during injection of high RF power. The outgassing strongly depended on the temperature of the test module, but was independent to initial temperature. The RF injection reduced outgassing. The outgassing rate decreased to a low level of 10 -6 -10 -5 Pa m 3 /sec m 2 (10 -9 -10 -8 Torr 1/sec cm 2 ) at 400degC after 450degC-baking. The gas injection did not affect outgassing before and during RF injection. The baking under H 2 or D 2 gas atmosphere were not so effective for reducing outgassing rate. The outgassing rate did not depend on input RF power densities. The temperature in central part of the test module saturated to be ∼100degC by using of water cooling at a power level of 150 MW/m 2 RF injection, and a neutral gas pressure decreased gradually. In the water cooling case, the outgassing rate was very low less than 10 -7 Pa m 3 /sec m 2 (10 -10 Torr 1/sec cm 2 ). The steady state RF injection was demonstrated with water cooling. (author)

  6. Fluorescence in situ hybridization in combination with the comet assay and micronucleus test in genetic toxicology

    Directory of Open Access Journals (Sweden)

    Hovhannisyan Galina G

    2010-09-01

    Full Text Available Abstract Comet assay and micronucleus (MN test are widely applied in genotoxicity testing and biomonitoring. While comet assay permits to measure direct DNA-strand breaking capacity of a tested agent MN test allows estimating the induced amount of chromosome and/or genome mutations. The potential of these two methods can be enhanced by the combination with fluorescence in situ hybridization (FISH techniques. FISH plus comet assay allows the recognition of targets of DNA damage and repairing directly. FISH combined with MN test is able to characterize the occurrence of different chromosomes in MN and to identify potential chromosomal targets of mutagenic substances. Thus, combination of FISH with the comet assay or MN test proved to be promising techniques for evaluation of the distribution of DNA and chromosome damage in the entire genome of individual cells. FISH technique also permits to study comet and MN formation, necessary for correct application of these methods. This paper reviews the relevant literature on advantages and limitations of Comet-FISH and MN-FISH assays application in genetic toxicology.

  7. Charpy impact test pada kampas rem hybrid komposit phenolic resin matrik dengan penguat serbuk basalt-Alumina-kulit kerang

    Directory of Open Access Journals (Sweden)

    I N. G. Suma Wijaya

    2017-03-01

    Full Text Available Abstrak: Penelitian ini adalah difokuskan untuk mengamati ketahanan impact dari material kampas rem kendaraan bermotor. Kampasrem yang diujikan adalah kampas yang terbuat dari material hybrid komposit dengan penguat serbuk basalt – serbuk kulitkerang dan alumina dan pengikat phenolic resin. Material kampas rem hibrid komposit diproses melalui proses sinteringdengan penekanan 2 ton, temperatur 150ºC selama 30 menit. Tujuan penelitian adalah menginvestigasi kekuatan impact daripada bahan hybrid komposit untuk masing – masing variasi terhadap perlakuan impact charpy yang didasarkan pada standarASTM D6110–04. Pengujian dilakukan dengan menganalisa nilai energy yang mampu diserap oleh bahan akibat bebanimpact, selanjutnya patahan impact charpy dianalisa dengan SEM. Diperoleh hasil pengujian charpy impact untuk masing –masing variasi hybrid komposit adalah nilai kekuatan yang tinggi terjadi pada hibrid komposit variasi 2 (HK2 dengan nilai0,000339547 J/mm2, ini disebabkan karena mempunyai ikatan antara metrik dan basalt yang lebih kuat dan sempurnadibandingkan dengan hibrid komposit lainnya. Untuk nilai hibrid komposit variasi 1 (HK1 adalah 0,000304851 J/mm², hibridkomposit variasi 3 (HK3 adalah 0,000334516 J/mm², hibrid komposit variasi 4 (HK4 adalah 0,000325059 J/mm², hibridkomposit variasi 5 (HK5 adalah 0,0003327 J/mm². (2 Dari perbandingan antara kampas rem dipasaran dengan kampas remhibrid komposit maka didapat nilai kekuatannya berbeda pada hibrid komposit variasi 2 (HK2 dengan kampas pembanding(KP yang memiliki nilai kekuatannya lebih besar yaitu, 0,000374867 J/mm².Kata kunci : Kampas rem, Impact charpy, Hibrid komposit, Basalt, Aluminium, Kulit Kerang Abstract: This research is focused to observe the impact resistance of motor vehicles brake lining material. Brake tested are canvasmade of hybrid composite materials with basalt powder reinforced – seashells, alumina powder, and a phenolic resin matrix.Hybrid composite brake

  8. The Successful Test Taker: Exploring Test-Taking Behavior Profiles through Cluster Analysis

    Science.gov (United States)

    Stenlund, Tova; Lyrén, Per-Erik; Eklöf, Hanna

    2018-01-01

    To be successful in a high-stakes testing situation is desirable for any test taker. It has been found that, beside content knowledge, test-taking behavior, such as risk-taking strategies, motivation, and test anxiety, is important for test performance. The purposes of the present study were to identify and group test takers with similar patterns…

  9. Electron temperature profiles in high power neutral-beam-heated TFTR [Tokamak Fusion Test Reactor] plasmas

    International Nuclear Information System (INIS)

    Taylor, G.; Grek, B.; Stauffer, F.J.; Goldston, R.J.; Fredrickson, E.D.; Wieland, R.M.; Zarnstorff, M.C.

    1987-09-01

    In 1986, the maximum neutral beam injection (NBI) power in the Tokamak Fusion Test Reactor (TFTR) was increased to 20 MW, with three beams co-parallel and one counter-parallel to I/sub p/. TFTR was operated over a wide range of plasma parameters; 2.5 19 19 m -3 . Data bases have been constructed with over 600 measured electron temperature profiles from multipoint TV Thomson scattering which span much of this parameter space. We have also examined electron temperature profile shapes from electron cyclotron emission at the fundamental ordinary mode and second harmonic extraordinary mode for a subset of these discharges. In the light of recent work on ''profile consistency'' we have analyzed these temperature profiles in the range 0.3 < (r/a) < 0.9 to determine if a profile shape exists which is insensitive to q/sub cyl/ and beam-heating profile. Data from both sides of the temperature profile [T/sub e/(R)] were mapped to magnetic flux surfaces [T/sub e/(r/a)]. Although T/sub e/(r/a), in the region where 0.3 < r/a < 0.9 was found to be slightly broader at lower q/sub cyl/, it was found to be remarkably insensitive to β/sub p/, to the fraction of NBI power injected co-parallel to I/sub p/, and to the heating profile going from peaked on axis, to hollow. 10 refs., 8 figs

  10. Electric and Plug-In Hybrid Electric Fleet Vehicle Testing | Transportation

    Science.gov (United States)

    Research | NREL Electric and Plug-In Hybrid Electric Fleet Vehicle Evaluations Electric and Plug-In Hybrid Electric Fleet Vehicle Evaluations How Electric and Plug-In Hybrid Electric Vehicles plugging the vehicle into an electric power source. PHEVs are powered by an internal combustion engine that

  11. Quantum confinement and dielectric profiles of colloidal nanoplatelets of halide inorganic and hybrid organic-inorganic perovskites

    Science.gov (United States)

    Sapori, Daniel; Kepenekian, Mikaël; Pedesseau, Laurent; Katan, Claudine; Even, Jacky

    2016-03-01

    Quantum confinement as well as high frequency ε∞ and static εs dielectric profiles are described for nanoplatelets of halide inorganic perovskites CsPbX3 (X = I, Br, Cl) and hybrid organic-inorganic perovskites (HOP) in two-dimensional (2D) and three-dimensional (3D) structures. 3D HOP are currently being sought for their impressive photovoltaic ability. Prior to this sudden popularity, 2D HOP materials were driving intense activity in the field of optoelectronics. Such developments have been enriched by the recent ability to synthesize colloidal nanostructures of controlled sizes of 2D and 3D HOP. This raises the need to achieve a thorough description of the electronic structure and dielectric properties of these systems. In this work, we go beyond the abrupt dielectric interface model and reach the atomic scale description. We examine the influence of the nature of the halogen and of the cation on the band structure and dielectric constants. Similarly, we survey the effect of dimensionality and shape of the perovskite. In agreement with recent experimental results, we show an increase of the band gap and a decrease of ε∞ when the size of a nanoplatelet reduces. By inspecting 2D HOP, we find that it cannot be described as a simple superposition of independent inorganic and organic layers. Finally, the dramatic impact of ionic contributions on the dielectric constant εs is analysed.Quantum confinement as well as high frequency ε∞ and static εs dielectric profiles are described for nanoplatelets of halide inorganic perovskites CsPbX3 (X = I, Br, Cl) and hybrid organic-inorganic perovskites (HOP) in two-dimensional (2D) and three-dimensional (3D) structures. 3D HOP are currently being sought for their impressive photovoltaic ability. Prior to this sudden popularity, 2D HOP materials were driving intense activity in the field of optoelectronics. Such developments have been enriched by the recent ability to synthesize colloidal nanostructures of controlled

  12. Comparison of the cobas Human Papillomavirus (HPV) Test with the Hybrid Capture 2 and Linear Array HPV DNA Tests

    Science.gov (United States)

    Sadorra, Mark; LaMere, Brandon J.; Kail, Randi; Aldrich, Carrie; Kinney, Walter; Fetterman, Barbara; Lorey, Thomas; Schiffman, Mark; Castle, Philip E.

    2012-01-01

    The cobas human papillomavirus (HPV) test (cobas) was recently approved by the U.S. Food and Drug Administration (FDA) and identifies HPV16 and HPV18 separately as well as detecting a pool of 11 HR-HPV genotypes (HPV31, -33, -35, -39, -45, -51, -52, -56, -58, -59, -68) and also HPV66. We compared cobas, Linear Array (LA), and Hybrid Capture 2 (HC2) assays for detection of carcinogenic HPV DNA, and cobas and LA for detection of HPV16 and HPV18 DNA, among the first 1,852 women enrolled in the HPV Persistence and Progression Cohort (PaP Cohort) study. Specimens were tested by all 3 assays 1 year after an HC2-positive result. In 1,824 specimens with cobas results, cobas had an 85.9% agreement with HC2 and 91.0% agreement with LA for carcinogenic HPV detection. When results between cobas and HC2 disagreed, cobas tended to call more women HPV positive (P < 0.01). Categorizing cobas and LA results hierarchically according to cancer risk (HPV16, HPV18, other carcinogenic HPV genotypes, or carcinogen negative), there was a 90% agreement for all categories of HPV (n = 1,824). We found good agreement between the two U.S. FDA-approved HPV tests, with discrepancies between the two assays due to specific characteristics of the individual assays. Additional studies are needed to compare HC2 and cobas for detecting and predicting CIN3 to understand the clinical implications of the discrepant test results between the two tests. PMID:22075592

  13. OLED Hybrid Integrated Polymer Microfluidic Biosensing for Point of Care Testing

    Directory of Open Access Journals (Sweden)

    Ashwin Acharya

    2015-09-01

    Full Text Available This paper reports a microfluidic platform with external hybrid integration of an organic light emitting diode (OLED as an excitation source. This device can be used as a simple and cost effective biosensing element. The device is capable of rapid in-situ detection of biological elements such as sensing of interaction of antigen with fluorescent tagged antibody conjugates. These portable microfluidic systems have great potential for use an OLED in a single chip with very high accuracy and sensitivity for various point-of-care (POC diagnosis and lab on a chip (LOC applications, as the miniaturization of the biosensor is essential for handling smaller sample volumes in order to achieve high throughput. The biosensing element was successfully tested to detect anti-sheep IgG conjugates tagged to Alexafluor using a fluorescence based immunoassay method.

  14. The Effect of Electric Load Profiles on the Performance of Off-Grid Residential Hybrid Renewable Energy Systems

    Directory of Open Access Journals (Sweden)

    Stephen Treado

    2015-10-01

    Full Text Available This paper investigates the energy performance of off-grid residential hybrid renewable electric power systems, particularly the effect of electric load profiles on the ability to harvest available solar energy and avoid the consumption of auxiliary energy in the form of propane. The concepts are illustrated by an analysis of the energy performance of electric and propane-fired refrigerators. Off-grid electric power systems frequently incorporate a renewable source, such as wind or solar photovoltaic (PV, with a back-up power provided by a propane fueled motor/generator. Among other design decisions, residential consumers face the choice of employing an electric refrigerator with a conventional vapor compression refrigeration system, or a fuel-fired refrigerator operating as an absorption refrigeration system. One interesting question is whether it is more advantageous from an energy perspective to use electricity to run the refrigerator, which might be provided by some combination of the PV and propane motor/generator, thereby taking advantage of the relatively higher electric refrigerator Coefficient of Performance (COP and free solar energy but having to accept a low electrical conversion efficiency of the motor/generator, or use thermal energy from the combustion of propane to produce the refrigeration effect via an absorption system, albeit with a much lower COP. The analysis is complicated by the fact that most off-grid renewable electrical power systems utilize a battery bank to provide electrical power when it is not available from the wind turbine or PV system, so the state of charge of the battery bank will have a noticeable impact on what energy source is available at any moment in time. Daily electric load profiles combined with variable solar energy input determine the state of charge of the battery bank, with the degree of synchronization between the two being a critical factor in determining performance. The annual energy usage

  15. Suppression subtractive hybridization profiles of radial growth phase and metastatic melanoma cell lines reveal novel potential targets

    International Nuclear Information System (INIS)

    Sousa, Josane F; Espreafico, Enilza M

    2008-01-01

    Melanoma progression occurs through three major stages: radial growth phase (RGP), confined to the epidermis; vertical growth phase (VGP), when the tumor has invaded into the dermis; and metastasis. In this work, we used suppression subtractive hybridization (SSH) to investigate the molecular signature of melanoma progression, by comparing a group of metastatic cell lines with an RGP-like cell line showing characteristics of early neoplastic lesions including expression of the metastasis suppressor KISS1, lack of αvβ3-integrin and low levels of RHOC. Two subtracted cDNA collections were obtained, one (RGP library) by subtracting the RGP cell line (WM1552C) cDNA from a cDNA pool from four metastatic cell lines (WM9, WM852, 1205Lu and WM1617), and the other (Met library) by the reverse subtraction. Clones were sequenced and annotated, and expression validation was done by Northern blot and RT-PCR. Gene Ontology annotation and searches in large-scale melanoma expression studies were done for the genes identified. We identified 367 clones from the RGP library and 386 from the Met library, of which 351 and 368, respectively, match human mRNA sequences, representing 288 and 217 annotated genes. We confirmed the differential expression of all genes selected for validation. In the Met library, we found an enrichment of genes in the growth factors/receptor, adhesion and motility categories whereas in the RGP library, enriched categories were nucleotide biosynthesis, DNA packing/repair, and macromolecular/vesicular trafficking. Interestingly, 19% of the genes from the RGP library map to chromosome 1 against 4% of the ones from Met library. This study identifies two populations of genes differentially expressed between melanoma cell lines from two tumor stages and suggests that these sets of genes represent profiles of less aggressive versus metastatic melanomas. A search for expression profiles of melanoma in available expression study databases allowed us to point to a

  16. Formulation and Testing of Paraffin-Based Solid Fuels Containing Energetic Additives for Hybrid Rockets

    Science.gov (United States)

    Larson, Daniel B.; Boyer, Eric; Wachs,Trevor; Kuo, Kenneth K.; Story, George

    2012-01-01

    Many approaches have been considered in an effort to improve the regression rate of solid fuels for hybrid rocket applications. One promising method is to use a fuel with a fast burning rate such as paraffin wax; however, additional performance increases to the fuel regression rate are necessary to make the fuel a viable candidate to replace current launch propulsion systems. The addition of energetic and/or nano-sized particles is one way to increase mass-burning rates of the solid fuels and increase the overall performance of the hybrid rocket motor.1,2 Several paraffin-based fuel grains with various energetic additives (e.g., lithium aluminum hydride (LiAlH4) have been cast in an attempt to improve regression rates. There are two major advantages to introducing LiAlH4 additive into the solid fuel matrix: 1) the increased characteristic velocity, 2) decreased dependency of Isp on oxidizer-to-fuel ratio. The testing and characterization of these solid-fuel grains have shown that continued work is necessary to eliminate unburned/unreacted fuel in downstream sections of the test apparatus.3 Changes to the fuel matrix include higher melting point wax and smaller energetic additive particles. The reduction in particle size through various methods can result in more homogeneous grain structure. The higher melting point wax can serve to reduce the melt-layer thickness, allowing the LiAlH4 particles to react closer to the burning surface, thus increasing the heat feedback rate and fuel regression rate. In addition to the formulation of LiAlH4 and paraffin wax solid-fuel grains, liquid additives of triethylaluminum and diisobutylaluminum hydride will be included in this study. Another promising fuel formulation consideration is to incorporate a small percentage of RDX as an additive to paraffin. A novel casting technique will be used by dissolving RDX in a solvent to crystallize the energetic additive. After dissolving the RDX in a solvent chosen for its compatibility

  17. High RF power test of a CFC antenna module for lower hybrid current drive

    International Nuclear Information System (INIS)

    Maebara, S.; Seki, M.; Ikeda, Y.; Kiyono, K.; Suganuma, K.; Imai, T.; Goniche, M.; Bibet, Ph.; Brossaud, J.; Cano, V.; Kazarian-Vibert, F.; Froissard, P.; Rey, G.

    1998-01-01

    A mock-up of a 3.7 GHz Lower Hybrid Current Drive (LHCD) antenna module was fabricated from Carbon Fibre Composite (CFC) for the development of heat resistive low Z front facing the plasma. This 2 divided waveguide module is made from CFC plates and rods which are Cu-plated to reduce the RF losses. The withstand-voltage, the RF properties and the outgassing rates for long pulses and high RF power were tested at the Lower Hybrid test bed facility of Cadarache. A reference module made from Dispersion Strengthened Copper (DSC) was also fabricated. After the short pulse conditioning, long pulses with a power density ranging between 50 and 150 MW/m 2 were performed with no breakdowns on the CFC module. It was also checked that the highest power density, up to 150 MW/m 2 , could be transmitted when the waveguides are filled with H2 at a pressure of 5 x 10 -2 Pa. During a long pulse, the power reflection coefficient remains low in the 0.8-1.3 % range and no significant change in the reflection coefficient is measured after the thermal cycling provided by the long pulse operation. From thermocouple measurements, RF losses of the copper coated CFC and the DSC modules were compared. No significant differences were measured. From pressure measurements, it was found that the outgassing rate of Cu-plated CFC is about 6-7 times larger than of DSC at 300 deg.C. It is concluded that a CFC module is an attractive candidate for the hardening of the tip of the LHCD antenna. (author)

  18. Performance test of lower hybrid waveguide under long/high-RF power transmission

    Energy Technology Data Exchange (ETDEWEB)

    Seki, Masami; Obara, Kenjiro; Maebara, Sunao [Japan Atomic Energy Research Inst., Naka, Ibaraki (Japan). Naka Fusion Research Establishment; and others

    1996-06-01

    Performance tests of a module for lower hybrid waveguides were carried out at the CEA Cadarache RF Test Facility. For the experiments the test module was fabricated by JAERI, the transmission line of the test bed was modified and the connection waveguides were manufactured by CEA. As the results, the thermal treatment by baking at a higher temperature was the most effective for reducing outgassing during injection of high RF power. The outgassing strongly depended on the temperature of the test module, but was independent to initial temperature. The RF injection reduced outgassing. The outgassing rate decreased to a low level of 10{sup -6}-10{sup -5} Pa m{sup 3}/sec m{sup 2} (10{sup -9}-10{sup -8} Torr 1/sec cm{sup 2}) at 400degC after 450degC-baking. The gas injection did not affect outgassing before and during RF injection. The baking under H{sub 2} or D{sub 2} gas atmosphere were not so effective for reducing outgassing rate. The outgassing rate did not depend on input RF power densities. The temperature in central part of the test module saturated to be {approx}100degC by using of water cooling at a power level of 150 MW/m{sup 2} RF injection, and a neutral gas pressure decreased gradually. In the water cooling case, the outgassing rate was very low less than 10{sup -7} Pa m{sup 3}/sec m{sup 2} (10{sup -10} Torr 1/sec cm{sup 2}). The steady state RF injection was demonstrated with water cooling. (author).

  19. Design, fabrication, and testing of a SMA hybrid composite jet engine chevron

    Science.gov (United States)

    Turner, Travis L.; Cabell, Randolph H.; Cano, Roberto J.; Fleming, Gary A.

    2006-01-01

    Control of jet noise continues to be an important research topic. Exhaust nozzle chevrons have been shown to reduce jet noise, but parametric effects are not well understood. Additionally, thrust loss due to chevrons at cruise suggests significant benefit from deployable chevrons. The focus of this study is development of an active chevron concept for the primary purpose of parametric studies for jet noise reduction in the laboratory and technology development to leverage for full scale systems. The active chevron concept employed in this work consists of a laminated composite structure with embedded shape memory alloy (SMA) actuators, termed a SMA hybrid composite (SMAHC). The actuators are embedded on one side of the middle surface such that thermal excitation generates a moment and deflects the structure. A brief description of the chevron design is given followed by details of the fabrication approach. Results from bench top tests are presented and correlated with numerical predictions from a model for such structures that was recently implemented in MSC.Nastran and ABAQUS. Excellent performance and agreement with predictions is demonstrated. Results from tests in a representative flow environment are also presented. Excellent performance is again achieved for both open- and closed-loop tests, the latter demonstrating control to a specified immersion into the flow. The actuation authority and immersion performance is shown to be relatively insensitive to nozzle pressure ratio (NPR). Very repeatable immersion control with modest power requirements is demonstrated.

  20. NASA ERA Integrated CFD for Wind Tunnel Testing of Hybrid Wing-Body Configuration

    Science.gov (United States)

    Garcia, Joseph A.; Melton, John E.; Schuh, Michael; James, Kevin D.; Long, Kurt R.; Vicroy, Dan D.; Deere, Karen A.; Luckring, James M.; Carter, Melissa B.; Flamm, Jeffrey D.; hide

    2016-01-01

    NASAs Environmentally Responsible Aviation (ERA) Project explores enabling technologies to reduce aviations impact on the environment. One research challenge area for the project has been to study advanced airframe and engine integration concepts to reduce community noise and fuel burn. In order to achieve this, complex wind tunnel experiments at both the NASA Langley Research Centers (LaRC) 14x22 and the Ames Research Centers 40x80 low-speed wind tunnel facilities were conducted on a Boeing Hybrid Wing Body (HWB) configuration. These wind tunnel tests entailed various entries to evaluate the propulsion airframe interference effects including aerodynamic performance and aeroacoustics. In order to assist these tests in producing high quality data with minimal hardware interference, extensive Computational Fluid Dynamic (CFD) simulations were performed for everything from sting design and placement for both the wing body and powered ejector nacelle systems to the placement of aeroacoustic arrays to minimize its impact on the vehicles aerodynamics. This paper will provide a high level summary of the CFD simulations that NASA performed in support of the model integration hardware design as well as some simulation guideline development based on post-test aerodynamic data. In addition, the paper includes details on how multiple CFD codes (OVERFLOW, STAR-CCM+, USM3D, and FUN3D) were efficiently used to provide timely insight into the wind tunnel experimental setup and execution.

  1. Development and Testing of a Green-Propellant Micro-Hybrid Thruster with Electrostatic Ignition

    Science.gov (United States)

    Whitmore, Stephen A.; Judson, Michael D.

    2012-01-01

    , requiring an energy input of 14,850 Joules for catalytic dissociation. The hydrocarbon-seeded micro-hybrid was also adapted as a non-pyrotechnic ignitor for a 900 N (200-lbf) thrust hybrid motor. The motor was successfully ignited 4 consecutive times with no hardware swaps or propellant additions. The amount of ABS seed material that can be fit into the injector cap is the only limit to the number of available repeat firings. This series of tests marks the first time a hybrid motor was ever ignited by other than a solid-propellant pyrotechnic charge or bi-propellant flame ignitor. Nitrous oxide hybrid motors are typically difficult to ignite and usually require multiple solid-propellant charges to initiate combustion, so this nonpyrotechnic ignition is a significant accomplishment. The controlled hydrocarbon-seeding approach is fundamentally different from all other green propellant solutions offered by the aerospace industry. Although the proposed system is more correctly a hybrid technology; the system retains all the simple features of a monopropellant design. To date no optimization study has been performed to identify the best grain geometry for electrostatic ignition. Fortunately, because the grain segments are fabricated using rapid-prototyping technology, changing the grain geometry is as simple as modifying the 3-D printer CAD-file. Vacuum Isp exceeding 270 seconds has been demonstrated (Ref v), a value significantly higher than those offered by competing green monopropellant options. The propellants of choice, N2O/GOX and ABS are 100% non-toxic, non-explosive, and environmentally benign. Because the inert oxidizer and fuel components are mixed only within the combustion chamber, the system retains the inherent safety of a hybrid rocket and can be piggy-backed as a secondary payload with no overall mission risk increase to the primary payload, an excellent characteristic for secondary launch systems.

  2. On-chip multiplexed solid-phase nucleic acid hybridization assay using spatial profiles of immobilized quantum dots and fluorescence resonance energy transfer.

    Science.gov (United States)

    Noor, M Omair; Tavares, Anthony J; Krull, Ulrich J

    2013-07-25

    A microfluidic based solid-phase assay for the multiplexed detection of nucleic acid hybridization using quantum dot (QD) mediated fluorescence resonance energy transfer (FRET) is described herein. The glass surface of hybrid glass-polydimethylsiloxane (PDMS) microfluidic channels was chemically modified to assemble the biorecognition interface. Multiplexing was demonstrated using a detection system that was comprised of two colors of immobilized semi-conductor QDs and two different oligonucleotide probe sequences. Green-emitting and red-emitting QDs were paired with Cy3 and Alexa Fluor 647 (A647) labeled oligonucleotides, respectively. The QDs served as energy donors for the transduction of dye labeled oligonucleotide targets. The in-channel assembly of the biorecognition interface and the subsequent introduction of oligonucleotide targets was accomplished within minutes using a combination of electroosmotic flow and electrophoretic force. The concurrent quantification of femtomole quantities of two target sequences was possible by measuring the spatial coverage of FRET sensitized emission along the length of the channel. In previous reports, multiplexed QD-FRET hybridization assays that employed a ratiometric method for quantification had challenges associated with lower analytical sensitivity arising from both donor and acceptor dilution that resulted in reduced energy transfer pathways as compared to single-color hybridization assays. Herein, a spatial method for quantification that is based on in-channel QD-FRET profiles provided higher analytical sensitivity in the multiplexed assay format as compared to single-color hybridization assays. The selectivity of the multiplexed hybridization assays was demonstrated by discrimination between a fully-complementary sequence and a 3 base pair sequence at a contrast ratio of 8 to 1. Copyright © 2013 Elsevier B.V. All rights reserved.

  3. Testing parasite 'intimacy': the whipworm Trichuris muris in the European house mouse hybrid zone.

    Science.gov (United States)

    Wasimuddin; Bryja, Josef; Ribas, Alexis; Baird, Stuart J E; Piálek, Jaroslav; Goüy de Bellocq, Joëlle

    2016-05-01

    Host-parasite interaction studies across hybrid zones often focus on host genetic variation, treating parasites as homogeneous. 'Intimately' associated hosts and parasites might be expected to show similar patterns of genetic structure. In the literature, factors such as no intermediate host and no free-living stage have been proposed as 'intimacy' factors likely constraining parasites to closely follow the evolutionary history of their hosts. To test whether the whipworm, Trichuris muris, is intimately associated with its house mouse host, we studied its population genetics across the European house mouse hybrid zone (HMHZ) which has a strong central barrier to gene flow between mouse taxa. T. muris has a direct life cycle and nonmobile free stage: if these traits constrain the parasite to an intimate association with its host we expect a geographic break in the parasite genetic structure across the HMHZ. We genotyped 205 worms from 56 localities across the HMHZ and additionally T. muris collected from sympatric woodmice (Apodemus spp.) and allopatric murine species, using mt-COX1, ITS1-5.8S-ITS2 rDNA and 10 microsatellites. We show four haplogroups of mt-COX1 and three clear ITS1-5.8S-ITS2 clades in the HMHZ suggesting a complex demographic/phylogeographic history. Microsatellites show strong structure between groups of localities. However, no marker type shows a break across the HMHZ. Whipworms from Apodemus in the HMHZ cluster, and share mitochondrial haplotypes, with those from house mice. We conclude Trichuris should not be regarded as an 'intimate' parasite of the house mouse: while its life history might suggest intimacy, passage through alternate hosts is sufficiently common to erase signal of genetic structure associated with any particular host taxon.

  4. Henry Agard Wallace, the Iowa Corn Yield Tests, and the Adoption of Hybrid Corn

    OpenAIRE

    Richard C. Sutch

    2008-01-01

    This research report makes the following claims: 1] There was not an unambiguous economic advantage of hybrid corn over the open-pollinated varieties in 1936. 2] The early adoption of hybrid corn before 1937 can be better explained by a sustained propaganda campaign conducted by the U.S. Department of Agriculture at the direction of the Secretary of Agriculture, Henry Agard Wallace. The Department's campaign echoed that of the commercial seed companies. The most prominent hybrid seed company,...

  5. Feasibility study on the demonstrative test on the hybrid mini hydroelectric power generation technology. 2; Hybrid gata mini suiryoku hatsuden gijutsu ni kakawaru jissho shiken kanosei chosa. 2

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-03-01

    A study was made for the purpose of electrification of unelectrified zones of the mountainous areas in developing countries using extremely small hydroelectric power facilities. The target for this project is a development of a micro hydroelectric power system with a size of about 5kW, which is estimated regarding that 1 village has 80 houses and each house needs electricity of 60W. In the study, the low-head system using a weir of irrigation channels in Subang pref. of West Java state was selected by the evaluation of access, stability of flow rate, natural conditions, etc. The hydroelectric power plant is of a flow-in method in which water is taken from the left bank and is injected/discharged to the downstream of the left bank. As the hybrid complementary power source, hybrid battery with a two-hour charging time at peak and a capacity of 3.5kWh was considered. When estimating the construction cost of the hybrid micro hydroelectric power system and equalizing by durable years, the operational cost per kW is 15 times higher than the benefits which local people receive. It was judged to be difficult to say that the micro hydroelectric power system is economically feasible. It was predicted that the financial profit during the demonstrative test is good, according to a trial calculation of income from power rates and the operational cost. 18 refs., 90 figs., 53 tabs.

  6. Testing the capacity of a Multi-Nutrient profiling system to guide food and beverage reformulation

    NARCIS (Netherlands)

    Combet, Emilie; Vlassopoulos, Antonis; Molenberg, Famke; Gressier, Mathilde; Privet, Lisa; Wratten, Craig; Sharif, Sahar; Vieux, Florent; Lehmann, Undine; Masset, Gabriel

    2017-01-01

    Nutrient profiling ranks foods based on their nutrient composition, with applications in multiple aspects of food policy. We tested the capacity of a category-specific model developed for product reformulation to improve the average nutrient content of foods, using five national food composition

  7. Evaluation of the preliminary auditory profile test battery in an international multi-centre study

    NARCIS (Netherlands)

    van Esch, T.E.M.; Kollmeier, B.; Vormann, M.; Lijzenga, J.; Houtgast, T.; Hallgren, M.; Larsby, B.; Athalye, S.P.; Lutman, M.E.; Dreschler, W.A.

    2013-01-01

    Objective: This paper describes the composition and international multi-centre evaluation of a battery of tests termed the preliminary auditory profile. It includes measures of loudness perception, listening effort, speech perception, spectral and temporal resolution, spatial hearing, self-reported

  8. mRMR-ABC: A Hybrid Gene Selection Algorithm for Cancer Classification Using Microarray Gene Expression Profiling

    Directory of Open Access Journals (Sweden)

    Hala Alshamlan

    2015-01-01

    Full Text Available An artificial bee colony (ABC is a relatively recent swarm intelligence optimization approach. In this paper, we propose the first attempt at applying ABC algorithm in analyzing a microarray gene expression profile. In addition, we propose an innovative feature selection algorithm, minimum redundancy maximum relevance (mRMR, and combine it with an ABC algorithm, mRMR-ABC, to select informative genes from microarray profile. The new approach is based on a support vector machine (SVM algorithm to measure the classification accuracy for selected genes. We evaluate the performance of the proposed mRMR-ABC algorithm by conducting extensive experiments on six binary and multiclass gene expression microarray datasets. Furthermore, we compare our proposed mRMR-ABC algorithm with previously known techniques. We reimplemented two of these techniques for the sake of a fair comparison using the same parameters. These two techniques are mRMR when combined with a genetic algorithm (mRMR-GA and mRMR when combined with a particle swarm optimization algorithm (mRMR-PSO. The experimental results prove that the proposed mRMR-ABC algorithm achieves accurate classification performance using small number of predictive genes when tested using both datasets and compared to previously suggested methods. This shows that mRMR-ABC is a promising approach for solving gene selection and cancer classification problems.

  9. mRMR-ABC: A Hybrid Gene Selection Algorithm for Cancer Classification Using Microarray Gene Expression Profiling.

    Science.gov (United States)

    Alshamlan, Hala; Badr, Ghada; Alohali, Yousef

    2015-01-01

    An artificial bee colony (ABC) is a relatively recent swarm intelligence optimization approach. In this paper, we propose the first attempt at applying ABC algorithm in analyzing a microarray gene expression profile. In addition, we propose an innovative feature selection algorithm, minimum redundancy maximum relevance (mRMR), and combine it with an ABC algorithm, mRMR-ABC, to select informative genes from microarray profile. The new approach is based on a support vector machine (SVM) algorithm to measure the classification accuracy for selected genes. We evaluate the performance of the proposed mRMR-ABC algorithm by conducting extensive experiments on six binary and multiclass gene expression microarray datasets. Furthermore, we compare our proposed mRMR-ABC algorithm with previously known techniques. We reimplemented two of these techniques for the sake of a fair comparison using the same parameters. These two techniques are mRMR when combined with a genetic algorithm (mRMR-GA) and mRMR when combined with a particle swarm optimization algorithm (mRMR-PSO). The experimental results prove that the proposed mRMR-ABC algorithm achieves accurate classification performance using small number of predictive genes when tested using both datasets and compared to previously suggested methods. This shows that mRMR-ABC is a promising approach for solving gene selection and cancer classification problems.

  10. Test-beam Results from a RICH Detector Prototype Using Aerogel Radiator and Pixel Hybrid Photon Detectors

    CERN Document Server

    Aglieri-Rinella, G; Van Lysebetten, A; Piedigrossi, D; Wyllie, K; Bellunato, T F; Calvi, M; Matteuzzi, C; Musy, M; Perego, D L; Somerville, L P; Newby, C; Easo, S; Wotton, S

    2006-01-01

    A test-beam study was performed at CERN with a Ring Imaging Cherenkov (RICH) prototype using three pixel Hybrid Photon Detectors. Results on the photon yield and Cherenkov angle resolution are presented here, for the Aerogel radiator and also for reference runs taken with Nitrogen radiator.

  11. Micro-hybrid electric vehicle application of valve-regulated lead-acid batteries in absorbent glass mat technology: Testing a partial-state-of-charge operation strategy

    Energy Technology Data Exchange (ETDEWEB)

    Schaeck, S.; Stoermer, A.O.; Hockgeiger, E. [BMW Group, Powertrain Development, Energy Storage, Hufelandstrasse 4, 80788 Muenchen (Germany)

    2009-05-01

    The BMW Group has launched two micro-hybrid functions in high volume models in order to contribute to reduction of fuel consumption in modern passenger cars. Both the brake energy regeneration (BER) and the auto-start-stop function (ASSF) are based on the conventional 14 V vehicle electrical system and current series components with only little modifications. An intelligent control algorithm of the alternator enables recuperative charging in braking and coasting phases, known as BER. By switching off the internal combustion engine at a vehicle standstill the idling fuel consumption is effectively reduced by ASSF. By reason of economy and package a lead-acid battery is used as electrochemical energy storage device. The BMW Group assembles valve-regulated lead-acid (VRLA) batteries in absorbent glass mat (AGM) technology in the micro-hybrid electrical power system since special challenges arise for the batteries. By field data analysis a lower average state-of-charge (SOC) due to partial state-of-charge (PSOC) operation and a higher cycling rate due to BER and ASSF are confirmed in this article. Similar to a design of experiment (DOE) like method we present a long-term lab investigation. Two types of 90 Ah VRLA AGM batteries are operated with a test bench profile that simulates the micro-hybrid vehicle electrical system under varying conditions. The main attention of this lab testing is focused on capacity loss and charge acceptance over cycle life. These effects are put into context with periodically refresh charging the batteries in order to prevent accelerated battery aging due to hard sulfation. We demonstrate the positive effect of refresh chargings concerning preservation of battery charge acceptance. Furthermore, we observe moderate capacity loss over 90 full cycles both at 25 C and at 3 C battery temperature. (author)

  12. Micro-hybrid electric vehicle application of valve-regulated lead-acid batteries in absorbent glass mat technology: Testing a partial-state-of-charge operation strategy

    Science.gov (United States)

    Schaeck, S.; Stoermer, A. O.; Hockgeiger, E.

    The BMW Group has launched two micro-hybrid functions in high volume models in order to contribute to reduction of fuel consumption in modern passenger cars. Both the brake energy regeneration (BER) and the auto-start-stop function (ASSF) are based on the conventional 14 V vehicle electrical system and current series components with only little modifications. An intelligent control algorithm of the alternator enables recuperative charging in braking and coasting phases, known as BER. By switching off the internal combustion engine at a vehicle standstill the idling fuel consumption is effectively reduced by ASSF. By reason of economy and package a lead-acid battery is used as electrochemical energy storage device. The BMW Group assembles valve-regulated lead-acid (VRLA) batteries in absorbent glass mat (AGM) technology in the micro-hybrid electrical power system since special challenges arise for the batteries. By field data analysis a lower average state-of-charge (SOC) due to partial state-of-charge (PSOC) operation and a higher cycling rate due to BER and ASSF are confirmed in this article. Similar to a design of experiment (DOE) like method we present a long-term lab investigation. Two types of 90 Ah VRLA AGM batteries are operated with a test bench profile that simulates the micro-hybrid vehicle electrical system under varying conditions. The main attention of this lab testing is focused on capacity loss and charge acceptance over cycle life. These effects are put into context with periodically refresh charging the batteries in order to prevent accelerated battery aging due to hard sulfation. We demonstrate the positive effect of refresh chargings concerning preservation of battery charge acceptance. Furthermore, we observe moderate capacity loss over 90 full cycles both at 25 °C and at 3 °C battery temperature.

  13. Characterisation of metal–thermoplastic composite hybrid joints by means of a mandrel peel test

    NARCIS (Netherlands)

    Su, Yibo; de Rooij, Matthias B.; Grouve, Wouter Johannes Bernardus; Warnet, Laurent

    2016-01-01

    Fastener free metal–carbon fibre reinforced thermoplastic composite hybrid joints show potential for application in aerospace structures. The strength of the metal–thermoplastic composite interface is crucial for the performance of the entire hybrid joint. Optimisation of the interface requires an

  14. Testing the Efficacy of MyPsychlab to Replace Traditional Instruction in a Hybrid Course

    Science.gov (United States)

    Powers, Kasey L.; Brooks, Patricia J.; Galazyn, Magdalena; Donnelly, Seamus

    2016-01-01

    Online course-packs are marketed as improving grades in introductory-level coursework, yet it is unknown whether these course-packs can effectively replace, as opposed to supplement, in-class instruction. This study compared learning outcomes for Introductory Psychology students in hybrid and traditional sections, with hybrid sections replacing…

  15. Sandwich nucleic acid hybridization: a method with a universally usable labeled probe for various specific tests

    International Nuclear Information System (INIS)

    Wolf, H.; Leser, U.; Haus, M.; Gu, S.Y.; Pathmanathan, R.

    1986-01-01

    The use of recombinant m13 phages as hybridization probes offers a considerable advantage over the commonly used recombinant plasmids as the preparation of the DNA probe is very simple and it can easily be labeled directly, e.g. with isotopes with long half-life like 125 I and used for hybridization. However, as the application of nucleic acid hybridization for diagnostic and epidemiological purposes becomes almost unavoidable, the logistic problems of keeping numerous individually labeled hybridization probes increase considerably and may reach prohibitory levels in less well-equipped laboratories. In a new sandwich technique, the first step involves hybridization with an unlabeled recombinant m13 DNA carrying an insert of the desired specificity. In a second step a universally usable labeled probe directed against the m13 part of the recombinant phage DNA is applied. This reduces considerably the problem of preparing and keeping multiple labeled probes in stock. (Auth.)

  16. Implementation and Operational Research: Cost and Efficiency of a Hybrid Mobile Multidisease Testing Approach With High HIV Testing Coverage in East Africa.

    Science.gov (United States)

    Chang, Wei; Chamie, Gabriel; Mwai, Daniel; Clark, Tamara D; Thirumurthy, Harsha; Charlebois, Edwin D; Petersen, Maya; Kabami, Jane; Ssemmondo, Emmanuel; Kadede, Kevin; Kwarisiima, Dalsone; Sang, Norton; Bukusi, Elizabeth A; Cohen, Craig R; Kamya, Moses; Havlir, Diane V; Kahn, James G

    2016-11-01

    In 2013-2014, we achieved 89% adult HIV testing coverage using a hybrid testing approach in 32 communities in Uganda and Kenya (SEARCH: NCT01864603). To inform scalability, we sought to determine: (1) overall cost and efficiency of this approach; and (2) costs associated with point-of-care (POC) CD4 testing, multidisease services, and community mobilization. We applied microcosting methods to estimate costs of population-wide HIV testing in 12 SEARCH trial communities. Main intervention components of the hybrid approach are census, multidisease community health campaigns (CHC), and home-based testing for CHC nonattendees. POC CD4 tests were provided for all HIV-infected participants. Data were extracted from expenditure records, activity registers, staff interviews, and time and motion logs. The mean cost per adult tested for HIV was $20.5 (range: $17.1-$32.1) (2014 US$), including a POC CD4 test at $16 per HIV+ person identified. Cost per adult tested for HIV was $13.8 at CHC vs. $31.7 by home-based testing. The cost per HIV+ adult identified was $231 ($87-$1245), with variability due mainly to HIV prevalence among persons tested (ie, HIV positivity rate). The marginal costs of multidisease testing at CHCs were $1.16/person for hypertension and diabetes, and $0.90 for malaria. Community mobilization constituted 15.3% of total costs. The hybrid testing approach achieved very high HIV testing coverage, with POC CD4, at costs similar to previously reported mobile, home-based, or venue-based HIV testing approaches in sub-Saharan Africa. By leveraging HIV infrastructure, multidisease services were offered at low marginal costs.

  17. Human papillomavirus testing in primary cervical screening and the cut-off level for hybrid capture 2 tests

    DEFF Research Database (Denmark)

    Rebolj, Matejka; Bonde, Jesper; Njor, Sisse Helle

    2011-01-01

    To determine the trade-off between the sensitivity and the specificity for high grade cervical intraepithelial neoplasia at hybrid capture 2 cut-off values above the standard = 1 relative light units/cut-off level (rlu/co).......To determine the trade-off between the sensitivity and the specificity for high grade cervical intraepithelial neoplasia at hybrid capture 2 cut-off values above the standard = 1 relative light units/cut-off level (rlu/co)....

  18. Use of Pearson's Chi-Square for Testing Equality of Percentile Profiles across Multiple Populations.

    Science.gov (United States)

    Johnson, William D; Beyl, Robbie A; Burton, Jeffrey H; Johnson, Callie M; Romer, Jacob E; Zhang, Lei

    2015-08-01

    In large sample studies where distributions may be skewed and not readily transformed to symmetry, it may be of greater interest to compare different distributions in terms of percentiles rather than means. For example, it may be more informative to compare two or more populations with respect to their within population distributions by testing the hypothesis that their corresponding respective 10 th , 50 th , and 90 th percentiles are equal. As a generalization of the median test, the proposed test statistic is asymptotically distributed as Chi-square with degrees of freedom dependent upon the number of percentiles tested and constraints of the null hypothesis. Results from simulation studies are used to validate the nominal 0.05 significance level under the null hypothesis, and asymptotic power properties that are suitable for testing equality of percentile profiles against selected profile discrepancies for a variety of underlying distributions. A pragmatic example is provided to illustrate the comparison of the percentile profiles for four body mass index distributions.

  19. Hybrid quantum logic and a test of Bell's inequality using two different atomic isotopes.

    Science.gov (United States)

    Ballance, C J; Schäfer, V M; Home, J P; Szwer, D J; Webster, S C; Allcock, D T C; Linke, N M; Harty, T P; Aude Craik, D P L; Stacey, D N; Steane, A M; Lucas, D M

    2015-12-17

    Entanglement is one of the most fundamental properties of quantum mechanics, and is the key resource for quantum information processing (QIP). Bipartite entangled states of identical particles have been generated and studied in several experiments, and post-selected or heralded entangled states involving pairs of photons, single photons and single atoms, or different nuclei in the solid state, have also been produced. Here we use a deterministic quantum logic gate to generate a 'hybrid' entangled state of two trapped-ion qubits held in different isotopes of calcium, perform full tomography of the state produced, and make a test of Bell's inequality with non-identical atoms. We use a laser-driven two-qubit gate, whose mechanism is insensitive to the qubits' energy splittings, to produce a maximally entangled state of one (40)Ca(+) qubit and one (43)Ca(+) qubit, held 3.5 micrometres apart in the same ion trap, with 99.8 ± 0.6 per cent fidelity. We test the CHSH (Clauser-Horne-Shimony-Holt) version of Bell's inequality for this novel entangled state and find that it is violated by 15 standard deviations; in this test, we close the detection loophole but not the locality loophole. Mixed-species quantum logic is a powerful technique for the construction of a quantum computer based on trapped ions, as it allows protection of memory qubits while other qubits undergo logic operations or are used as photonic interfaces to other processing units. The entangling gate mechanism used here can also be applied to qubits stored in different atomic elements; this would allow both memory and logic gate errors caused by photon scattering to be reduced below the levels required for fault-tolerant quantum error correction, which is an essential prerequisite for general-purpose quantum computing.

  20. Towards Reconfigurable, Separable and Hard Real-Time Hybrid Simulation and Test Systems

    Science.gov (United States)

    Quartier, F.; Delatte, B.; Joubert, M.

    2009-05-01

    Formation flight needs several new technologies, new disciplines, new approaches and above all, more concurrent engineering by more players. One of the problems to be addressed are more complex simulation and test systems that are easy to re-configure to include parts of the target hardware and that can provide sufficient power to handle simulation cores that are requiring one to two orders of magnitude more processing power than the current technology provides. Critical technologies that are already addressed by CNES and Spacebel are study model reuse and simulator reconfigurability (Basiles), model portability (SMP2) and the federation of several simulators using HLA. Two more critical issues are addressed in ongoing R&D work by CNES and Spacebel and are covered by this paper and concern the time engineering and management. The first issue concerns separability (characterisation, identification and handling of separable subsystems) and the consequences on practical systems. Experiments on the Pleiades operational simulator have shown that adding precise simulation of instruments such as Doris and the Star Tracker can be added without significantly impacting overall performance. Improved time analysis leads to better system understanding and testability. The second issue concerns architectures for distributed hybrid simulators systems that provide hard real-time capabilities and can react with a relative time precision and jitter that is in the 10 to 50 µsecond range using mainstream PC's and mainstream Operating Systems. This opens a way to make smaller economic hardware test systems that can be reconfigured to make large hardware test systems without restarting development. Although such systems were considered next to impossible till now, distributed hard real-time systems are getting in reach when modern but mainstream electronics are used and when processor cores can be isolated and reserved for real-time cores. This requires a complete rethinking of the

  1. Gene expression profiles of prohibitin in testes of Octopus tankahkeei (ot-phb) revealing its possible role during spermiogenesis.

    Science.gov (United States)

    Mao, Hai-Tao; Wang, Da-Hui; Lan, Zhou; Zhou, Hong; Yang, Wan-Xi

    2012-05-01

    Prohibitin is essential for intracellular homeostasis and stabilization of mitochondrial respiratory chain complexes. To explore its functions during spermiogenesis of Octopus tankahkeei (O. tankahkeei), we have cloned and sequenced the cDNA of this mammalian PHB homologue (termed ot-PHB) from the testes of O. tankahkeei. The 1165 bp ot-phb cDNA contains a 100 bp 5' UTR, a 882 bp open reading frame and a 183 bp 3' UTR. The putative ot-PHB protein owns a transmembrane domain from 6 to 31 amino acid (aa) and a putative PHB domain from 26 to 178 aa. Protein alignment demonstrated that ot-PHB had 73.3, 73.6, 74.0, 75.1, and 45.4% identity with its homologues in Homo sapiens, Mus muculus, Danio rerio, Xenopus tropicalis and Trypanosoma brucei, respectively. Tissue distribution profile analysis revealed its presence in all the tissues examined. In situ hybridization in spermiogenic cells demonstrated that ot-phb was expressed moderately at the beginning of the spermiogenesis. The abundance of transcripts increased in intermediate spermatids and in drastically remodeling final spermatids. In mature spermatozoa, the residuary transcripts concentrated around the chondriosomal mantle where mitochondria assemble around. In summary, the expression of ot-phb during spermiogenesis implicates a potential function of this protein during mitochondrial ubiquitination. It is the first time to implicate the role of prohibitin in cephalopod spermiogenesis.

  2. Modeling and Experimental Tests of a Mechatronic Device to Measure Road Profiles Considering Impact Dynamics

    DEFF Research Database (Denmark)

    Souza, A.; Santos, Ilmar

    2002-01-01

    of a vehicle and to test its components in laboratory. In this framework a mechanism to measure road profiles is designed and presented. Such a mechanism is composed of two rolling wheels and two long beams attached to the vehicles by means of four Kardan joints. The wheels are kept in contact to the ground...... to highlight that the aim of this device is to independently measure two road profiles, without the influence of the vehicle dynamics where the mechanism is attached. Before the mechatronic mechanism is attached to a real vehicle, its dynamic behavior must be known. A theoretical analysis of the mechanism...... predicts well the mechanism movements. However it was also experimentally observed that the contact between the wheels and the road profile is not permanent. To analyze the non-contact between the wheels and the road, the Newton-Euler´s Method is used to calculate forces and moments of reactions between...

  3. Characteristic Analysis and Simulated Test of Hybrid Bearing with the Introduction of Piezoelectric Controller

    Directory of Open Access Journals (Sweden)

    Runlin Chen

    2016-01-01

    Full Text Available A novel hybrid bearing with the introduction of piezoelectric controller and tilting pads to control vibration actively is proposed in this paper, and the feasibility of this scheme is verified by theoretical calculation and experimental data. This scheme can control the vibration of bearing actively by using the electromechanical characteristics of piezoelectric ceramic transducer (PZT components. The static internal character of PZT and static external characteristic of piezoelectric control component are analyzed, and the calculation equations of preload coefficient and driving force of the new bearing are given. The simulation setup of the new bearing is designed and developed. The data representing the relationship of displacement of pad pivot, driving force, voltage, and the simulation stiffness of liquid film are obtained in the test, and the feature parameters of piezoelectric control component are amended to analyze the relationship between preload coefficient of the bearing and driving voltage. The proposed new bearing has the function of controlling preload actively. The theoretical and experimental research results provide essential guidance for the detail design of this new bearing and also provide a new idea for the vibration control of high speed rotor systems.

  4. Testing Two Nutrient Profiling Models of Labelled Foods and Beverages Marketed in Turkey.

    Science.gov (United States)

    Dikmen, Derya; Kızıl, Mevlüde; Uyar, Muhemmet Fatih; Pekcan, Gülden

    2015-06-01

    The objective of this study was to evaluate the nutrient profile of labelled foods and also understand the application of two international nutrient profiling models of labelled foods and beverages. WXYfm and NRF 9.3 nutrient profiling models were used to evaluate 3,171 labelled foods and beverages of 38 food categories and 500 different brands. According to the WXYfm model, pasta, grains and legumes and frozen foods had the best scores whereas oils had the worst scores. According to the NRF 9.3 model per 100 kcal, the best scores were obtained for frozen foods, grains and legumes and milk products whereas the confectionery foods had the worst scores. According to NRF 9.3 per serving size, grains and legumes had the best scores and flavoured milks had the worst scores. A comparison of WXYfm and NRF 9.3 nutrient profiling models ranked scores showed a high positive correlation (p=0.01). The two nutrient models evaluated yielded similar results. Further studies are needed to test other category specific nutrient profiling models in order to understand how different models behave. Copyright© by the National Institute of Public Health, Prague 2015.

  5. Time-varying Entry Heating Profile Replication with a Rotating Arc Jet Test Article

    Science.gov (United States)

    Grinstead, Jay Henderson; Venkatapathy, Ethiraj; Noyes, Eric A.; Mach, Jeffrey J.; Empey, Daniel M.; White, Todd R.

    2014-01-01

    A new approach for arc jet testing of thermal protection materials at conditions approximating the time-varying conditions of atmospheric entry was developed and demonstrated. The approach relies upon the spatial variation of heat flux and pressure over a cylindrical test model. By slowly rotating a cylindrical arc jet test model during exposure to an arc jet stream, each point on the test model will experience constantly changing applied heat flux. The predicted temporal profile of heat flux at a point on a vehicle can be replicated by rotating the cylinder at a prescribed speed and direction. An electromechanical test model mechanism was designed, built, and operated during an arc jet test to demonstrate the technique.

  6. Diagnose Test-Taker's Profile in Terms of Core Profile Patterns: Principal Component (PC) vs. Profile Analysis via MDS (PAMS) Approaches.

    Science.gov (United States)

    Kim, Se-Kang; Davison, Mark L.

    A study was conducted to examine how principal components analysis (PCA) and Profile Analysis via Multidimensional Scaling (PAMS) can be used to diagnose individuals observed score profiles in terms of core profile patterns identified by each method. The standardization sample from the Wechsler Intelligence Scale for Children, Third Edition…

  7. Fuel Economy and Performance of Mild Hybrids with Ultracapacitors: Simulations and Vehicle Test Results (Presentation)

    Energy Technology Data Exchange (ETDEWEB)

    Gonder, J.; Pesaran, A.; Lustbader, J.; Tataria, H.

    2009-06-01

    NREL worked with GM and demonstrated equivalent performance in the Saturn Vue Belt Alternator Starter (BAS) hybrid vehicle whether running with its stock batteries or a retrofit ultracapacitor system.

  8. evaluation of striga-resistant early maize hybrids and test locations

    African Journals Online (AJOL)

    Prof. Adipala Ekwamu

    to evaluate selected Striga-resistant maize (Zea mays L.) hybrids for grain yield and stability of .... Analysis of variance procedure is useful for ... however, variance components alone do not ... for analysing multi-environment trial MET data.

  9. Transient Lift-Off Test Results for an Experimental Hybrid Bearing in Air

    Science.gov (United States)

    2009-12-01

    bearings. The electric motor designed to drive the rotor is a high speed integral motorized spindle unit manufactured by SKF Precision Technologies and...create pressure that supports the rotor ( shaft ) without rotation. The pressure generated by the flow through an orifice gives the hybrid bearing a...Kettering University; Chair of Advisory Committee: Dr. Dara Childs A hybrid bearing designed for use in a next generation turbo-pump is

  10. Occupant kinematics in low-speed frontal sled tests: Human volunteers, Hybrid III ATD, and PMHS.

    Science.gov (United States)

    Beeman, Stephanie M; Kemper, Andrew R; Madigan, Michael L; Franck, Christopher T; Loftus, Stephen C

    2012-07-01

    A total of 34 dynamic matched frontal sled tests were performed, 17 low (2.5g, Δv=4.8kph) and 17 medium (5.0g, Δv=9.7kph), with five male human volunteers of approximately 50th percentile height and weight, a Hybrid III 50th percentile male ATD, and three male PMHS. Each volunteer was exposed to two impulses at each severity, one relaxed and one braced prior to the impulse. A total of four tests were performed at each severity with the ATD and one trial was performed at each severity with each PMHS. A Vicon motion analysis system, 12 MX-T20 2 megapixel cameras, was used to quantify subject 3D kinematics (±1mm) (1kHz). Excursions of select anatomical regions were normalized to their respective initial positions and compared by test condition and between subject types. The forward excursions of the select anatomical regions generally increased with increasing severity. The forward excursions of relaxed human volunteers were significantly larger than those of the ATD for nearly every region at both severities. The forward excursions of the upper body regions of the braced volunteers were generally significantly smaller than those of the ATD at both severities. Forward excursions of the relaxed human volunteers and PMHSs were fairly similar except the head CG response at both severities and the right knee and C7 at the medium severity. The forward excursions of the upper body of the PMHS were generally significantly larger than those of the braced volunteers at both severities. Forward excursions of the PMHSs exceeded those of the ATD for all regions at both severities with significant differences within the upper body regions. Overall human volunteers, ATD, and PMHSs do not have identical biomechanical responses in low-speed frontal sled tests but all contribute valuable data that can be used to refine and validate computational models and ATDs used to assess injury risk in automotive collisions. Copyright © 2012 Elsevier Ltd. All rights reserved.

  11. Method for determining detailed rod worth profiles at low power in the fast test reactor

    International Nuclear Information System (INIS)

    Sevenich, R.A.

    1975-08-01

    A method for obtaining a detailed rod worth profile at low power for a slow control rod insertion is presented. The accuracy of the method depends on a preparatory experiment in which the test rod is dropped quickly to yield, upon analysis, the magnitude of the rod worth and an effective source value. These numbers are employed to initialize the inverse kinetics analysis for the slow insertion. Corrections for changes in detection efficiency are not included for the simulated experiments. (U.S.)

  12. Logrank Test and Interval Overlap Test for Bactericera cockerelli (Hemiptera: Triozidae) Under Different Fertilization Treatments for 7705 Tomato Hybrid

    Science.gov (United States)

    Vargas-Madríz, Haidel; Bautista-Martínez, Néstor; Vera-Graziano, Jorge; Sánchez-García, Prometeo; García-Gutiérrez, Cipriano; Sánchez-Soto, Saúl; de Jesús García-Avila, Clemente

    2014-01-01

    Abstract It is known that some nutrients can have both negative and positive effects on some populations of insects. To test this, the Logrank test and the Interval Overlap Test were evaluated for two crop cycles (February–May and May–August) of the 7705 tomato hybrid, and the effect on the psyllid, Bactericera cockerelli (Sulc.) (Hemiptera: Triozidae), was examined under greenhouse conditions. Tomato plants were in polythene bags and irrigated with the following solutions: T1—Steiner solution, T2—Steiner solution with nitrogen reduced to 25%, T3—Steiner solution with potassium reduced to 25%, and T4—Steiner solution with calcium reduced to 25%. In the Logrank test, a significant difference was found when comparing the survival parameters of B. cockerelli generated from the treatment cohorts: T1–T2; T1–T3; T1–T4; T2–T3; and T3–T4, while no significant differences were found in the T2–T4 comparison in the February–May cycle. In the May–August cycle, significant differences were found when comparing the survival parameters generated from the treatment cohorts: T1–T2; T1–T3; and T1–T4, while no significant differences were found in the T2–T3; T2–T4; and T3–T4 comparisons of survival parameters of B. cockerelli fed with the 7705 tomato hybrid. Also, the Interval Overlap Test was done on the treatment cohorts (T1, T2, T3, and T4) in the February–May and May–August cycles. T1 and T2 compare similarly in both cycles when feeding on the treatments up to 36 d. Similarly, in T1 and T3, the behavior of the insect is similar when feeding on the treatments up to 40 and 73 d, respectively. Comparisons T2–T3 and T2–T4 are similar when feeding on both treatments up to 42, 38 and 37, 63 d, respectively. Finally, the T3–T4 comparison was similar when feeding in both treatments up to 20 and 46 d, respectively. RESUMEN. Se sabe que algunos nutrientes pueden tener efectos tanto negativos como positivos en algunas poblaciones de

  13. The physical therapy profile questionnaire (PTPQ): development, validation and pilot testing.

    Science.gov (United States)

    Dizon, Janine Margarita R; Grimmer-Somers, Karen; Kumar, Saravana

    2011-09-19

    Country by country similarities and differences in physical therapy practice exists. Therefore, before updates in practice can be provided, such as trainings in evidence-based practice, it is necessary to identify the profile and nature of practice in a given country or setting. Following a search of the international literature, no appropriate tool was identified to collect and establish data to create the profile of physical therapy practice in the Philippines. We therefore developed, validated and pilot tested a survey instrument which would comprehensively describe the practice of physical therapy in the Philippines We used a mixed methods design to answer our study aims. A focus group interview was conducted among a group of physical therapists to establish the content and contexts of items to be included in the survey instrument. Findings were amalgamated with the information from the literature on developing survey instruments/questionnaires. A survey instrument was drafted and named as the Physical Therapy Profile Questionnaire (PTPQ). The PTPQ was then validated and pilot tested to a different group of physical therapists.The final version consisted of five separate parts namely (A) General information and demographics, (B) Practice Profile, (C) Treatment Preferences, (D) Bases for clinical work and (E) Bases for educational/research work. At present the PTPQ is relevant to the Philippines and could be used by any country which has a similar nature of practice with the Philippines. The Physical Therapy Practice Questionnaire (PTPQ) was shown to have good face and content validity among the Filipino physical therapists and their context of practice. It has also been found to be useful, easy to administer tool and in a format appealing to respondents. The PTPQ is expected to assist comprehensive data collection to create a profile of physical therapy practice in the Philippines.

  14. The physical therapy profile questionnaire (PTPQ: development, validation and pilot testing

    Directory of Open Access Journals (Sweden)

    Grimmer-Somers Karen

    2011-09-01

    Full Text Available Abstract Background Country by country similarities and differences in physical therapy practice exists. Therefore, before updates in practice can be provided, such as trainings in evidence-based practice, it is necessary to identify the profile and nature of practice in a given country or setting. Following a search of the international literature, no appropriate tool was identified to collect and establish data to create the profile of physical therapy practice in the Philippines. We therefore developed, validated and pilot tested a survey instrument which would comprehensively describe the practice of physical therapy in the Philippines Findings We used a mixed methods design to answer our study aims. A focus group interview was conducted among a group of physical therapists to establish the content and contexts of items to be included in the survey instrument. Findings were amalgamated with the information from the literature on developing survey instruments/questionnaires. A survey instrument was drafted and named as the Physical Therapy Profile Questionnaire (PTPQ. The PTPQ was then validated and pilot tested to a different group of physical therapists. The final version consisted of five separate parts namely (A General information and demographics, (B Practice Profile, (C Treatment Preferences, (D Bases for clinical work and (E Bases for educational/research work. At present the PTPQ is relevant to the Philippines and could be used by any country which has a similar nature of practice with the Philippines. Conclusion The Physical Therapy Practice Questionnaire (PTPQ was shown to have good face and content validity among the Filipino physical therapists and their context of practice. It has also been found to be useful, easy to administer tool and in a format appealing to respondents. The PTPQ is expected to assist comprehensive data collection to create a profile of physical therapy practice in the Philippines.

  15. An experimental study on the thermal-hydraulic phenomena in the Hybrid Safety Injection Tank using a separate effect test facility

    International Nuclear Information System (INIS)

    Ryu, Sung Uk; Ryu, Hyobong; Park, Hyun-Sik; Yi, Sung-Jae

    2016-01-01

    Highlights: • The experimental study on the pressure balancing between the Hybrid SIT and PZR. • The effects of different variables affecting the pressure balancing are investigated. • A sensitivity analysis on the pressure variations of the Hybrid SIT. - Abstract: This paper reports an experimental research for investigating thermal hydraulic phenomena of Hybrid Safety Injection Tank (Hybrid SIT) using a separate effect test facility in Korea Atomic Energy Research Institute (KAERI). The Hybrid SIT is a passive safety injection system that enables the safety injection water to be injected into the reactor pressure vessel throughout all operating pressures by connecting the top of the SIT and the pressurizer (PZR). The separate effect test (SET) facility of Hybrid SIT, which is designed based on the APR+ power plant, comprises a PZR, Hybrid SIT, pressure balancing line (PBL), injection line (IL), nitrogen gas line, and refueling water tank (RWT). Furthermore, the pressure loss range of the SET facility was analyzed and compared with that of the reference nuclear power plant. In this research, a condition for balancing the pressure between the Hybrid SIT and PZR is examined and the effects of different variables affecting the pressure balancing, which are flow rate, injection velocity of steam and initial water level, are also investigated. The condition for balancing the pressure between the Hybrid SIT and PZR was derived theoretically from a pressure network for the Hybrid SIT, pressurizer, and reactor pressure vessel. Additionally, a sensitivity analysis as a theoretical approach was conducted on the pressure variations in relation to the rate of steam condensation inside the Hybrid SIT. The results showed that pressure of the Hybrid SIT was predominantly determined by the rate of steam condensation. The results showed that if the rate of condensation increased or decreased by 10%, the Hybrid SIT pressure at the pressure balancing point decreased or

  16. Equivalence Testing of Complex Particle Size Distribution Profiles Based on Earth Mover's Distance.

    Science.gov (United States)

    Hu, Meng; Jiang, Xiaohui; Absar, Mohammad; Choi, Stephanie; Kozak, Darby; Shen, Meiyu; Weng, Yu-Ting; Zhao, Liang; Lionberger, Robert

    2018-04-12

    Particle size distribution (PSD) is an important property of particulates in drug products. In the evaluation of generic drug products formulated as suspensions, emulsions, and liposomes, the PSD comparisons between a test product and the branded product can provide useful information regarding in vitro and in vivo performance. Historically, the FDA has recommended the population bioequivalence (PBE) statistical approach to compare the PSD descriptors D50 and SPAN from test and reference products to support product equivalence. In this study, the earth mover's distance (EMD) is proposed as a new metric for comparing PSD particularly when the PSD profile exhibits complex distribution (e.g., multiple peaks) that is not accurately described by the D50 and SPAN descriptor. EMD is a statistical metric that measures the discrepancy (distance) between size distribution profiles without a prior assumption of the distribution. PBE is then adopted to perform statistical test to establish equivalence based on the calculated EMD distances. Simulations show that proposed EMD-based approach is effective in comparing test and reference profiles for equivalence testing and is superior compared to commonly used distance measures, e.g., Euclidean and Kolmogorov-Smirnov distances. The proposed approach was demonstrated by evaluating equivalence of cyclosporine ophthalmic emulsion PSDs that were manufactured under different conditions. Our results show that proposed approach can effectively pass an equivalent product (e.g., reference product against itself) and reject an inequivalent product (e.g., reference product against negative control), thus suggesting its usefulness in supporting bioequivalence determination of a test product to the reference product which both possess multimodal PSDs.

  17. Genetic profiles of gastroesophageal cancer: combined analysis using expression array and tiling array--comparative genomic hybridization

    DEFF Research Database (Denmark)

    Isinger-Ekstrand, Anna; Johansson, Jan; Ohlsson, Mattias

    2010-01-01

    We aimed to characterize the genomic profiles of adenocarcinomas in the gastroesophageal junction in relation to cancers in the esophagus and the stomach. Profiles of gains/losses as well as gene expression profiles were obtained from 27 gastroesophageal adenocarcinomas by means of 32k high......15, 13q34, and 12q13, whereas different profiles with gains at 5p15, 7p22, 2q35, and 13q34 characterized gastric cancers. CDK6 and EGFR were identified as putative target genes in cancers of the esophagus and the gastroesophageal junction, with upregulation in one quarter of the tumors. Gains....../losses and gene expression profiles show strong similarity between cancers in the distal esophagus and the gastroesophageal junction with frequent upregulation of CDK6 and EGFR, whereas gastric cancer displays distinct genetic changes. These data suggest that molecular diagnostics and targeted therapies can...

  18. Results of the mission profile life test. [for J-series mercury ion engines

    Science.gov (United States)

    Bechtel, R. T.; Trump, G. E.; James, E. L.

    1982-01-01

    Seven J series 30-cm diameter thrusters have been tested in segments of up to 5,070 hr, for 14,541 hr in the Mission Profile Life Test facility. Test results have indicated the basic thruster design to be consistent with the lifetime goal of 15,000 hr at 2-A beam. The only areas of concern identified which appear to require additional verification testing involve contamination of mercury propellant isolators, which may be due to facility constituents, and the ability of specially covered surfaces to contain sputtered material and prevent flake formation. The ability of the SCR, series resonant inverter power processor to operate the J series thruster and autonomous computer control of the thruster/processor system were demonstrated.

  19. The impact of shape memory test on degradation profile of a bioresorbable polymer.

    Science.gov (United States)

    Musioł, Marta; Jurczyk, Sebastian; Kwiecień, Michał; Smola-Dmochowska, Anna; Domański, Marian; Janeczek, Henryk; Włodarczyk, Jakub; Klim, Magdalena; Rydz, Joanna; Kawalec, Michał; Sobota, Michał

    2018-05-01

    The semicrystalline poly(L-lactide) (PLLA) belongs to the materials with shape memory effect (SME) and as a bioresorbable and biocompatible polymer it have found many applications in medical and pharmaceutical field. Assessment of the SME impact on the polymer degradation profile plays crucial role in applications such as drug release systems or in regenerative medicine. Herein, the results of in vitro degradation studies of PLLA samples after SME full test cycle are presented. The samples were loaded and deformed in two manners: progressive and non-progressive. The performed experiments illustrate also influence of the material mechanical damages, caused e.g. during incorrect implantation of PLLA product, on hydrolytic degradation profile. Apparently, degradation profiles are significantly different for the material which was not subjected to the deformation and the deformed ones. The materials after deformation of 50% (in SME cycle) was characterized by non-reversible morphology changes. The effect was observed in deformed samples during the SME test which were carried out ten times. Copyright © 2018 Elsevier Ltd. All rights reserved.

  20. Design, testing, and performance of a hybrid micro vehicle---The Hopping Rotochute

    Science.gov (United States)

    Beyer, Eric W.

    The Hopping Rotochute is a new hybrid micro vehicle that has been developed to robustly explore environments with rough terrain while minimizing energy consumption over long periods of time. The device consists of a small coaxial rotor system housed inside a lightweight cage. The vehicle traverses an area by intermittently powering a small electric motor which drives the rotor system, allowing the vehicle to hop over obstacles of various shapes and sizes. A movable internal mass controls the direction of travel while the egg-like exterior shape and low mass center allows the vehicle to passively reorient itself to an upright attitude when in contact with the ground. This dissertation presents the design, fabrication, and testing of a radio-controlled Hopping Rotochute prototype as well as an analytical study of the flight performance of the device. The conceptual design iterations are first outlined which were driven by the mission and system requirements assigned to the vehicle. The aerodynamic, mechanical, and electrical design of a prototype is then described, based on the final conceptual design, with particular emphasis on the fundamental trades that must be negotiated for this type of hopping vehicle. The fabrication and testing of this prototype is detailed as well as experimental results obtained from a motion capture system. Basic flight performance of the prototype are reported which demonstrates that the Hopping Rotochute satisfies all appointed system requirements. A dynamic model of the Hopping Rotochute is also developed in this thesis and employed to predict the flight performance of the vehicle. The dynamic model includes aerodynamic loads from the body and rotor system as well as a soft contact model to estimate the forces and moments during ground contact. The experimental methods used to estimate the dynamic model parameters are described while comparisons between measured and simulated motion are presented. Good correlation between these motions

  1. Dual-colour chromogenic in-situ hybridization is a potential alternative to fluorescence in-situ hybridization in HER2 testing.

    Science.gov (United States)

    Hwang, Cheng-Cheng; Pintye, Mariann; Chang, Liang-Che; Chen, Huang-Yang; Yeh, Kun-Yan; Chein, Hui-Ping; Lee, Nin; Chen, Jim-Ray

    2011-11-01

    Dual-colour chromogenic in-situ hybridization (dc-CISH) is an emerging methodology for characterizing genomic alterations. This study was aimed at evaluating the performance of a dc-CISH kit (ZytoVision) in determining human epidermal growth factor receptor 2 (HER2) status in breast cancer. Two hundred and twenty-eight invasive breast carcinomas arranged in tissue microarrays were analysed in parallel with dc-CISH, fluorescence in-situ hybridization (FISH), and immunohistochemistry. Of 227 tumours with available FISH and dc-CISH results, HER2 amplification and non-amplification were detected in 49 (21.6%) and 178 (78.4%) tumours, respectively, by both assays. The concordance between dc-CISH and FISH results showed 100% agreement (κ-coefficient=1.00). Immunohistochemically, 162 (71%), 25 (11.0%) and 41 (18%) tumours were scored 0/1+, 2+, and 3+, respectively. The corresponding results with both FISH and dc-CISH demonstrated HER2 amplification in two (3.2%), nine (36%) and 38 (93%) tumours, respectively. Complete consensus among these three methods was observed in 197 cases, representing 98% of all 3+ and 0/1+ tumours (κ-coefficient=0.92). Confirmatory testing of 25 2+ tumours showed complete consensus between FISH and dc-CISH. dc-CISH is a promising alternative to FISH in HER2 testing, and the single-institute incidence of HER2 amplification in breast cancer in Taiwan is 21.2%. © 2011 Blackwell Publishing Limited.

  2. Testing a Cloud Provider Network for Hybrid P2P and Cloud Streaming Architectures

    OpenAIRE

    Cerviño Arriba, Javier; Rodríguez, Pedro; Trajkovska, Irena; Mozo Velasco, Alberto; Salvachúa Rodríguez, Joaquín

    2011-01-01

    The number of online real-time streaming services deployed over network topologies like P2P or centralized ones has remarkably increased in the recent years. This has revealed the lack of networks that are well prepared to respond to this kind of traffic. A hybrid distribution network can be an efficient solution for real-time streaming services. This paper contains the experimental results of streaming distribution in a hybrid architecture that consist of mixed connections among P2P and Clou...

  3. Test of the quasi-optical grill for lower hybrid current drive on the CASTOR tokamak

    International Nuclear Information System (INIS)

    Klima, R.; Pavlo, P.; Preinhaelter, J.; Stoeckel, J.; Zacek, F.; Jakubka, K.; Kletecka, P.; Kryska, L.

    1994-03-01

    Feasibility studies of a new diffraction structure for launching lower hybrid waves into a tokamak plasma - of the microwave quasi-optical grill - are reported. The main parameters of the grill designed for the CASTOR tokamak are summarized, and results of preliminary radiation pattern measurements of a non-optimized model antenna are presented. The influence of a relatively great curvature of the plasma surface in the CASTOR tokamak is discussed and the ray tracing of the launched lower-hybrid wave in the actual CASTOR plasma is shown. Finally, the results of probe measurements of the CASTOR plasma core are given. (J.U.) 17 figs., 9 refs

  4. Radioautographic test for genetic cotton transformation by pCaVItoxneo hybrid plasmid

    International Nuclear Information System (INIS)

    Imamkhodjaeva, A.S.

    2006-01-01

    Full text: Search for novel technologies in biology, application of up-to-date methods in gene engineering, manipulation with the recombinant DNA, in particular, open opportunities for experiments with plants. To identify some DNA fragments in an organism's genome, radioautographic methods, such as dot- and blot-hybridization are frequently used. As a rule, genomic DNA is first isolated from the plant's organ. Its purification and subsequent manipulation is followed by hybridization with a probe labeled with radioactive components. The purified DNA, cDNA of RNA reverse transcription or a DNA fragment cloned in E-coli could serve as the probe. Radioautography shows homologically hybridized fragments. We have performed express dot-hybridization analysis on hybrid plasmid transformation of G.Hirsutum L. (108F) and G. Barbadense L. (C-6037) cotton sorts. pCaVItoxneo plasmid obtained on the basis of independently replicated plasmid-like DNA of the G.Hirsutum L. (pGHm2) cotton mitochondria was used (Yusupov T., 1994). There are hybrid two-domain gene of insectotoxin and enzymatically active kanamycine - phosphotransferase in the plasmid. The whole content is controlled by the plant promoter of cauliflower mosaic virus (19 S SFMV). The plasmid in question was added to the pollen sprouting medium followed by the transfer of the suspension on the pistil stigmas of the pre-prepared cotton flowers. The seed budding as the result of the experiment were analyzed by means of dot-hybridization method. DNA probes used for radioactive hybridization were labeled by method of Fainberg and Vagelstein (1990). To perform that DNA was dissolved in Tris-EDTA (10:1), containing 10mM of Tris HCl and 1mM EDTA, denaturated at 100 d eg C for 2 minutes with subsequent addition of oligonucleotide primers and annealing. DNA synthesis in the presence of 32 P labeled dATP and dCTP (Tashkent) was performed in the reaction mixture of potassium-phosphate buffer containing 67mM of MgCl 2 , 1 mg/ml of

  5. Proteomic profiling of eggs from a hybrid abalone and its parental lines: Haliotis discus hannai Ino and Haliotis gigantea.

    Science.gov (United States)

    Di, Guilan; Luo, Xuan; Huang, Miaoqin; Chen, Jun; Kong, Xianghui; Miao, Xiulian; Ke, Caihuan

    2015-12-01

    Proteomic analysis was performed on the eggs of hybrid abalone and their corresponding parental lines. A total of 915 ± 19 stained protein spots were detected from Haliotis discus hannai♀ × H. discus hannai♂ (DD), 935 ± 16 from H. gigantea♀ × H. gigantea♂ (GG) and 923 ± 13 from H. gigantea♀ × H. discus hannai♂ (GD). The spots from DD and GD were clustered together. The distance between DD and GG was maximal by hierarchical cluster analysis. A total of 112 protein gel spots were identified; of these, 59 were abalone proteins. The proteins were involved in major biological processes including energy metabolism, proliferation, apoptosis, signal transduction, immunity, lipid metabolism, electron carrier proteins, protein biosynthesis and decomposition, and cytoskeletal structure. Three of 20 differential expression protein spots involved in energy metabolism exhibited as upregulated in GD, 13 spots exhibited additivity, and four spots exhibited as downregulated in the offspring. Eleven protein spots were expressed at the highest level in DD. The proteins involved in stress responses included superoxide dismutase, peroxiredoxin 6, thioredoxin peroxidase and glutathione-S-transferase. Two of seven differential expression protein spots involved in response to stress exhibited as upregulated in GD, three exhibited additivity, and two exhibited as downregulated. These results might suggest that proteomic approaches are suitable for the analysis of hybrids and the functional prediction of abalone hybridization. © 2015 Stichting International Foundation for Animal Genetics.

  6. Retrieval practice with short-answer, multiple-choice, and hybrid tests.

    Science.gov (United States)

    Smith, Megan A; Karpicke, Jeffrey D

    2014-01-01

    Retrieval practice improves meaningful learning, and the most frequent way of implementing retrieval practice in classrooms is to have students answer questions. In four experiments (N=372) we investigated the effects of different question formats on learning. Students read educational texts and practised retrieval by answering short-answer, multiple-choice, or hybrid questions. In hybrid conditions students first attempted to recall answers in short-answer format, then identified answers in multiple-choice format. We measured learning 1 week later using a final assessment with two types of questions: those that could be answered by recalling information verbatim from the texts and those that required inferences. Practising retrieval in all format conditions enhanced retention, relative to a study-only control condition, on both verbatim and inference questions. However, there were little or no advantages of answering short-answer or hybrid format questions over multiple-choice questions in three experiments. In Experiment 4, when retrieval success was improved under initial short-answer conditions, there was an advantage of answering short-answer or hybrid questions over multiple-choice questions. The results challenge the simple conclusion that short-answer questions always produce the best learning, due to increased retrieval effort or difficulty, and demonstrate the importance of retrieval success for retrieval-based learning activities.

  7. Cooperative test plots produce some promising Chinese and hybrid chestnut trees

    Science.gov (United States)

    Jesse D. Diller; Russell B. Clapper; Richard A. Jaynes

    1964-01-01

    In attempts to find a chestnut tree that is resistant to the blight fungus Endothia parasitica, Asiatic chestnuts have been imported and grown in this country, and tree breeders have worked to produce hybrid trees that might be suitable substitutes for the blight-susceptible American chestnut, Castanea dentate, in timber and nut...

  8. Diamond and cBN hybrid and nanomodified cutting tools with enhanced performance: Development, testing and modelling

    DEFF Research Database (Denmark)

    Loginov, Pavel; Mishnaevsky, Leon; Levashov, Evgeny

    2015-01-01

    with 25% of diamond replaced by cBN grains demonstrate 20% increased performance as compared with pure diamond machining tools, and more than two times higher performance as compared with pure cBN tools. Further, cast iron machining efficiency of the wheels modified by hBN particles was 80% more efficient......The potential of enhancement of superhard steel and cast iron cutting tool performance on the basis of microstuctural modifications of the tool materials is studied. Hybrid machining tools with mixed diamond and cBN grains, as well as machining tool with composite nanomodified metallic binder...... are developed, and tested experimentally and numerically. It is demonstrated that both combination of diamond and cBN (hybrid structure) and nanomodification of metallic binder (with hexagonal boron nitride/hBN platelets) lead to sufficient improvement of the cast iron machining performance. The superhard tools...

  9. Hybrid advection scheme for 3-dimensional atmospheric models. Testing and application for a study of NO{sub x} transport

    Energy Technology Data Exchange (ETDEWEB)

    Zubov, V A; Rozanov, E V [Main Geophysical Observatory, St.Petersburg (Russian Federation); Schlesinger, M E; Andronova, N G [Illinois Univ., Urbana-Champaign, IL (United States). Dept. of Atmospheric Sciences

    1998-12-31

    The problems of ozone depletion, climate change and atmospheric pollution strongly depend on the processes of production, destruction and transport of chemical species. A hybrid transport scheme was developed, consisting of the semi-Lagrangian scheme for horizontal advection and the Prather scheme for vertical transport, which have been used for the Atmospheric Chemical Transport model to calculate the distributions of different chemical species. The performance of the new hybrid scheme has been evaluated in comparison with other transport schemes on the basis of specially designed tests. The seasonal cycle of the distribution of N{sub 2}O simulated by the model, as well as the dispersion of NO{sub x} exhausted from subsonic aircraft, are in a good agreement with published data. (author) 8 refs.

  10. Hybrid advection scheme for 3-dimensional atmospheric models. Testing and application for a study of NO{sub x} transport

    Energy Technology Data Exchange (ETDEWEB)

    Zubov, V.A.; Rozanov, E.V. [Main Geophysical Observatory, St.Petersburg (Russian Federation); Schlesinger, M.E.; Andronova, N.G. [Illinois Univ., Urbana-Champaign, IL (United States). Dept. of Atmospheric Sciences

    1997-12-31

    The problems of ozone depletion, climate change and atmospheric pollution strongly depend on the processes of production, destruction and transport of chemical species. A hybrid transport scheme was developed, consisting of the semi-Lagrangian scheme for horizontal advection and the Prather scheme for vertical transport, which have been used for the Atmospheric Chemical Transport model to calculate the distributions of different chemical species. The performance of the new hybrid scheme has been evaluated in comparison with other transport schemes on the basis of specially designed tests. The seasonal cycle of the distribution of N{sub 2}O simulated by the model, as well as the dispersion of NO{sub x} exhausted from subsonic aircraft, are in a good agreement with published data. (author) 8 refs.

  11. Development and testing of multigroup library with correction of self-shielding effects in fusion-fission hybrid reactor

    International Nuclear Information System (INIS)

    Zou Jun; He Zhaozhong; Zeng Qin; Qiu Yuefeng; Wang Minghuang

    2010-01-01

    A multigroup library HENDL2.1/SS (Hybrid Evaluated Nuclear Data Library/Self-Shielding) based on ENDF/B-VII.0 evaluate data has been generated using Bondarenko and flux calculator method for the correction of self-shielding effect of neutronics analyses. To validate the reliability of the multigroup library HENDL2.1/SS, transport calculations for fusion-fission hybrid system FDS-I were performed in this paper. It was verified that the calculations with the HENDL2.1/SS gave almost the same results with MCNP calculations and were better than calculations with the HENDL2.0/MG which is another multigroup library without self-shielding correction. The test results also showed that neglecting resonance self-shielding caused underestimation of the K eff , neutron fluxes and waste transmutation ratios in the multigroup calculations of FDS-I.

  12. Development and psychometric testing of a trans-professional evidence-based practice profile questionnaire.

    Science.gov (United States)

    McEvoy, Maureen Patricia; Williams, Marie T; Olds, Timothy Stephen

    2010-01-01

    Previous survey tools operationalising knowledge, attitudes or beliefs about evidence-based practice (EBP) have shortcomings in content, psychometric properties and target audience. This study developed and psychometrically assessed a self-report trans-professional questionnaire to describe an EBP profile. Sixty-six items were collated from existing EBP questionnaires and administered to 526 academics and students from health and non-health backgrounds. Principal component factor analysis revealed the presence of five factors (Relevance, Terminology, Confidence, Practice and Sympathy). Following expert panel review and pilot testing, the 58-item final questionnaire was disseminated to 105 subjects on two occasions. Test-retest and internal reliability were quantified using intra-class correlation coefficients (ICCs) and Cronbach's alpha, convergent validity against a commonly used EBP questionnaire by Pearson's correlation coefficient and discriminative validity via analysis of variance (ANOVA) based on exposure to EBP training. The final questionnaire demonstrated acceptable internal consistency (Cronbach's alpha 0.96), test-retest reliability (ICCs range 0.77-0.94) and convergent validity (Practice 0.66, Confidence 0.80 and Sympathy 0.54). Three factors (Relevance, Terminology and Confidence) distinguished EBP exposure groups (ANOVA p profile (EBP(2)) questionnaire is a reliable instrument with the ability to discriminate for three factors, between respondents with differing EBP exposures.

  13. U.S. Department of Energy Vehicle Technologies Program: Battery Test Manual For Plug-In Hybrid Electric Vehicles

    Energy Technology Data Exchange (ETDEWEB)

    Christophersen, Jon P. [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2014-09-01

    This battery test procedure manual was prepared for the United States Department of Energy (DOE), Office of Energy Efficiency and Renewable Energy (EERE), Vehicle Technologies Office. It is based on technical targets for commercial viability established for energy storage development projects aimed at meeting system level DOE goals for Plug-in Hybrid Electric Vehicles (PHEV). The specific procedures defined in this manual support the performance and life characterization of advanced battery devices under development for PHEV’s. However, it does share some methods described in the previously published battery test manual for power-assist hybrid electric vehicles. Due to the complexity of some of the procedures and supporting analysis, future revisions including some modifications and clarifications of these procedures are expected. As in previous battery and capacitor test manuals, this version of the manual defines testing methods for full-size battery systems, along with provisions for scaling these tests for modules, cells or other subscale level devices. The DOE-United States Advanced Battery Consortium (USABC), Technical Advisory Committee (TAC) supported the development of the manual. Technical Team points of contact responsible for its development and revision are Renata M. Arsenault of Ford Motor Company and Jon P. Christophersen of the Idaho National Laboratory. The development of this manual was funded by the Unites States Department of Energy, Office of Energy Efficiency and Renewable Energy, Vehicle Technologies Office. Technical direction from DOE was provided by David Howell, Energy Storage R&D Manager and Hybrid Electric Systems Team Leader. Comments and questions regarding the manual should be directed to Jon P. Christophersen at the Idaho National Laboratory (jon.christophersen@inl.gov).

  14. The structured-objective rorschach test (sort occupational profile for state accountants

    Directory of Open Access Journals (Sweden)

    J. J. Gouws

    1996-06-01

    Full Text Available The objective of this study was to provide an occupational profile of performance on the Structured-Objective Rorschach Test (SORT by state accountants for use in guidance, election and placement of personnel. The sample comprised accountants and auditors from the financial sections in various state institutions who were selected for the Senior Financial Management Course at the University of Stellenbosch. As all participants were considered successful in their occupation and no significant differences were found between the profiles of various age and year groups, the SORT profile obtained for the total group can be used as a predictor to determine and evaluate the personality traits that are important in the profession of state accountant. Opsomming Die doel van hierdie studie was die daarstelling van 'n beroepsprofiel van staatsrekenmeesters se prestasie op die Gestruktureerd-Objektiewe Rorschachtoets (SORT wat vir voorligting/ keuring en plasing van personeel gebruik kan word. Die steekproef is saamgestel uit rekenmeesters en ouditeure van die finansiele afdelings in verskeie staatsinstansies wat geselekteer is vir die Senior Finansiele Bestuurskursus by die Universiteit van Stellenbosch. Aangesien alle deelnemers as suksesvol in hulle beroep beskou is en geen beduidende verskille in die profiele van verskillende ouderdomsgroepe en jaargroepe gevind is nie, kan die SORT profiel van die totale groep as 'n voorspeller gebruik word vir die bepaling en evaluering van die persoonlikheidseienskappe wat belangrik is in die beroep van staatsrekenmeester.

  15. Oilseed rape grain yield productivity increases with hybrid varietal types: a first balance sheet with post registration tests in France and in Europe

    Directory of Open Access Journals (Sweden)

    Pinochet Xavier

    2000-01-01

    Full Text Available Since 1994 several oilseed rape hybrid types were proposed to farmers. Following registration experiments, Cetiom and different equivalent institutions in European Union have tested them in different post registration national networks. Grain yield productivity increases were demonstrated and a first synthesis could be done to check avantages and difficulties which had occurred. For winter types, Hybrid Composits were widely used, mainly in France and in the United Kingdom. Grain yield increases were important in the South and West part of France where their market shares increased up to 50-80%. Nevertheless, many fecondation problems occurred in several places all over Europe. Reasons of such problems were difficult to identify. Several factors, as cold temperatures, nutritionnal competitions, pollen avaibility may be involved to explain low seed sets. Restored Hybrids made with the NPZ hybridation system were successfully tested widely, and has reached significative market shares during 1999-2000 season. Less experiments were carried out with others hybrid types (Ogu-INRA Restored Hybrids, Mixed Hybrids. Ogu-INRA Restored Hybrids reached the highest grain yield levels but users are waiting for lower glucosinolates seed content hybrids which would come in the next future. Performances comparisons among countries have to be done carefully. Productivity increases with hybrid types could have been over estimated depending of pollinic environments or plot size and possible neighbouring effects. For France, results from field trials networks are coherent with results coming from postal surveys. For spring varieties, Polima restored hybrids and varietal associations have demonstrated a significative advantage compared to classical lines.

  16. Changes in the Fatty Acid Profile and Phospholipid Molecular Species Composition of Human Erythrocyte Membranes after Hybrid Palm and Extra Virgin Olive Oil Supplementation.

    Science.gov (United States)

    Pacetti, D; Gagliardi, R; Balzano, M; Frega, N G; Ojeda, M L; Borrero, M; Ruiz, A; Lucci, P

    2016-07-13

    This work aims to evaluate and compare, for the first time, the effects of extra virgin olive oil (EVOO) and hybrid palm oil (HPO) supplementation on the fatty acid profile and phospholipid (PL) molecular species composition of human erythrocyte membranes. Results supported the effectiveness of both HPO and EVOO supplementation (3 months, 25 mL/day) in decreasing the lipophilic index of erythrocytes with no significant differences between HPO and EVOO groups at month 3. On the other hand, the novel and rapid ultraperformance liquid chromatography-tandem mass spectrometry method used for PL analysis reveals an increase in the levels of phosphatidylcholine and phosphatidylethanolamine species esterified with polyunsaturated fatty acids. This work demonstrates the ability of both EVOO and HPO to increase the degree of unsaturation of erythrocyte membrane lipids with an improvement in membrane fluidity that could be associated with a lower risk of developing cardiovascular diseases.

  17. RF design and tests on a broadband, high-power coaxial quadrature hybrid applicable to ITER ICRF transmission line system for load-resilient operations

    International Nuclear Information System (INIS)

    Kim, Hae Jin; Wang, Son Jong; Park, Byoung Ho; Kwak, Jong-Gu; Hillairet, Julien; Choi, Jin Joo

    2015-01-01

    Highlights: • Amplitude balanced 3 dB coaxial hybrid splitter has been designed and rf tested. • The proposed hybrid is applicable to ITER ICRF transmission line for load resilience. • Two-section, broadband coaxial hybrid can be tunable by changing dielectric insulator. - Abstract: RF design and network analyzer tests of broadband, amplitude-balanced coaxial hybrid junctions are presented. We have designed two 3 dB hybrid splitters with 9 and 12 in. coaxial transmission lines applicable to ITER ICRF for load-resilient operations using ANSYS HFSS. Amplitude-balanced broadband responses were obtained with the combination of impedance reductions of longitudinal and transverse branches in unequal proportion, length change of 50 Ω lines and diameter change of high impedance lines connected transversely to the T-section of the hybrid splitter, respectively. We have fabricated and RF tested the 9 in. coaxial hybrid coupler. We obtained an excellent coupling flatness of −3.2 ± 0.2 dB, phase difference of 4 degrees and return loss of 16 dB in 40–55 MHz. The measured data of 9 in. hybrid splitter is highly consistent with HFSS simulations. We found that the proposed 3 dB hybrid splitter can be tunable with amplitude-balanced, broadband response by changing dielectric insulators to keep the inner and outer conductors of coaxial line apart. The proposed 3 dB hybrid splitter can be utilized for load-resilient operations in a wide range of antenna load variations due to mode transitions or edge localized modes (ELMs) in fusion plasmas.

  18. RF design and tests on a broadband, high-power coaxial quadrature hybrid applicable to ITER ICRF transmission line system for load-resilient operations

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Hae Jin, E-mail: haejin@nfri.re.kr [National Fusion Research Institute, Daejeon (Korea, Republic of); Wang, Son Jong; Park, Byoung Ho; Kwak, Jong-Gu [National Fusion Research Institute, Daejeon (Korea, Republic of); Hillairet, Julien [CEA/IRFM, Saint-lez-Durance (France); Choi, Jin Joo [Kwangwoon University, Seoul (Korea, Republic of)

    2015-10-15

    Highlights: • Amplitude balanced 3 dB coaxial hybrid splitter has been designed and rf tested. • The proposed hybrid is applicable to ITER ICRF transmission line for load resilience. • Two-section, broadband coaxial hybrid can be tunable by changing dielectric insulator. - Abstract: RF design and network analyzer tests of broadband, amplitude-balanced coaxial hybrid junctions are presented. We have designed two 3 dB hybrid splitters with 9 and 12 in. coaxial transmission lines applicable to ITER ICRF for load-resilient operations using ANSYS HFSS. Amplitude-balanced broadband responses were obtained with the combination of impedance reductions of longitudinal and transverse branches in unequal proportion, length change of 50 Ω lines and diameter change of high impedance lines connected transversely to the T-section of the hybrid splitter, respectively. We have fabricated and RF tested the 9 in. coaxial hybrid coupler. We obtained an excellent coupling flatness of −3.2 ± 0.2 dB, phase difference of 4 degrees and return loss of 16 dB in 40–55 MHz. The measured data of 9 in. hybrid splitter is highly consistent with HFSS simulations. We found that the proposed 3 dB hybrid splitter can be tunable with amplitude-balanced, broadband response by changing dielectric insulators to keep the inner and outer conductors of coaxial line apart. The proposed 3 dB hybrid splitter can be utilized for load-resilient operations in a wide range of antenna load variations due to mode transitions or edge localized modes (ELMs) in fusion plasmas.

  19. Pharmacokinetic Profiling of Conjugated Therapeutic Oligonucleotides: A High-Throughput Method Based Upon Serial Blood Microsampling Coupled to Peptide Nucleic Acid Hybridization Assay.

    Science.gov (United States)

    Godinho, Bruno M D C; Gilbert, James W; Haraszti, Reka A; Coles, Andrew H; Biscans, Annabelle; Roux, Loic; Nikan, Mehran; Echeverria, Dimas; Hassler, Matthew; Khvorova, Anastasia

    2017-12-01

    Therapeutic oligonucleotides, such as small interfering RNAs (siRNAs), hold great promise for the treatment of incurable genetically defined disorders by targeting cognate toxic gene products for degradation. To achieve meaningful tissue distribution and efficacy in vivo, siRNAs must be conjugated or formulated. Clear understanding of the pharmacokinetic (PK)/pharmacodynamic behavior of these compounds is necessary to optimize and characterize the performance of therapeutic oligonucleotides in vivo. In this study, we describe a simple and reproducible methodology for the evaluation of in vivo blood/plasma PK profiles and tissue distribution of oligonucleotides. The method is based on serial blood microsampling from the saphenous vein, coupled to peptide nucleic acid hybridization assay for quantification of guide strands. Performed with minimal number of animals, this method allowed unequivocal detection and sensitive quantification without the need for amplification, or further modification of the oligonucleotides. Using this methodology, we compared plasma clearances and tissue distribution profiles of two different hydrophobically modified siRNAs (hsiRNAs). Notably, cholesterol-hsiRNA presented slow plasma clearances and mainly accumulated in the liver, whereas, phosphocholine-docosahexaenoic acid-hsiRNA was rapidly cleared from the plasma and preferably accumulated in the kidney. These data suggest that the PK/biodistribution profiles of modified hsiRNAs are determined by the chemical nature of the conjugate. Importantly, the method described in this study constitutes a simple platform to conduct pilot assessments of the basic clearance and tissue distribution profiles, which can be broadly applied for evaluation of new chemical variants of siRNAs and micro-RNAs.

  20. Design and Test of a Soil Profile Moisture Sensor Based on Sensitive Soil Layers

    Science.gov (United States)

    Liu, Cheng; Qian, Hongzhou; Cao, Weixing; Ni, Jun

    2018-01-01

    To meet the demand of intelligent irrigation for accurate moisture sensing in the soil vertical profile, a soil profile moisture sensor was designed based on the principle of high-frequency capacitance. The sensor consists of five groups of sensing probes, a data processor, and some accessory components. Low-resistivity copper rings were used as components of the sensing probes. Composable simulation of the sensor’s sensing probes was carried out using a high-frequency structure simulator. According to the effective radiation range of electric field intensity, width and spacing of copper ring were set to 30 mm and 40 mm, respectively. A parallel resonance circuit of voltage-controlled oscillator and high-frequency inductance-capacitance (LC) was designed for signal frequency division and conditioning. A data processor was used to process moisture-related frequency signals for soil profile moisture sensing. The sensor was able to detect real-time soil moisture at the depths of 20, 30, and 50 cm and conduct online inversion of moisture in the soil layer between 0–100 cm. According to the calibration results, the degree of fitting (R2) between the sensor’s measuring frequency and the volumetric moisture content of soil sample was 0.99 and the relative error of the sensor consistency test was 0–1.17%. Field tests in different loam soils showed that measured soil moisture from our sensor reproduced the observed soil moisture dynamic well, with an R2 of 0.96 and a root mean square error of 0.04. In a sensor accuracy test, the R2 between the measured value of the proposed sensor and that of the Diviner2000 portable soil moisture monitoring system was higher than 0.85, with a relative error smaller than 5%. The R2 between measured values and inversed soil moisture values for other soil layers were consistently higher than 0.8. According to calibration test and field test, this sensor, which features low cost, good operability, and high integration, is qualified for

  1. Very long pulse high-RF power test of a lower hybrid frequency antenna module

    Energy Technology Data Exchange (ETDEWEB)

    Goniche, M; Brossaud, J; Barral, C; Berger-By, G; Bibet, Ph; Poli, S; Rey, G; Tonon, G [Association Euratom-CEA, Centre d` Etudes Nucleaires de Cadarache, 13 - Saint-Paul-lez-Durance (France). Dept. de Recherches sur la Fusion Controlee; Seki, M; Obara, K [Japan Atomic Energy Research Inst., Naka, Ibaraki (Japan). Naka Fusion Research Establishment; and others

    1994-03-01

    Outgassing, induced by very long RF waves injection at high power density was studied in a module, able to be used for a lower hybrid frequency antenna. Good RF properties of the module are reported, however, resonance phenomena with strong absorption of RF power (15%) was observed at high temperature (T>400 deg C). A large outgassing data base is provided by the 75 shots cumulating 27 hours of RF injection. The comparison with previous experiments (Tore Supra and TdV prototype modules) confirm the effect of baking and results are consistent. Outgassing increases exponentially with -1/T, and a desorption model with an activation energy Ed {approx} 0.35 eV fits the data up to 400 deg C. In order to design vacuum pumping system for large lower hybrid frequency antenna, outgassing rates are given for different working temperatures. (author). 11 refs., 55 figs.

  2. Very long pulse high-RF power test of a lower hybrid frequency antenna module

    International Nuclear Information System (INIS)

    Goniche, M.; Brossaud, J.; Barral, C.; Berger-By, G.; Bibet, Ph.; Poli, S.; Rey, G.; Tonon, G.; Seki, M.; Obara, K.

    1994-03-01

    Outgassing, induced by very long RF waves injection at high power density was studied in a module, able to be used for a lower hybrid frequency antenna. Good RF properties of the module are reported, however, resonance phenomena with strong absorption of RF power (15%) was observed at high temperature (T>400 deg C). A large outgassing data base is provided by the 75 shots cumulating 27 hours of RF injection. The comparison with previous experiments (Tore Supra and TdV prototype modules) confirm the effect of baking and results are consistent. Outgassing increases exponentially with -1/T, and a desorption model with an activation energy Ed ∼ 0.35 eV fits the data up to 400 deg C. In order to design vacuum pumping system for large lower hybrid frequency antenna, outgassing rates are given for different working temperatures. (author). 11 refs., 55 figs

  3. Improving the AGR fuel testing power density profile versus irradiation-time in the advanced test reactor

    International Nuclear Information System (INIS)

    Chang, Gray S.; Lillo, Misti A.; Maki, John T.; Petti, David A.

    2009-01-01

    The Very High Temperature gas-cooled Reactor (VHTR), which is currently being developed, achieves simplification of safety through reliance on ceramic-coated fuel particles. Each TRISO-coated fuel particle has its own containment which serves as the principal barrier against radionuclide release under normal operating and accident conditions. These fuel particles, in the form of graphite fuel compacts, are currently undergoing a series of irradiation tests in the Advanced Test Reactor (ATR) at the Idaho National Laboratory (INL) to support the Advanced Gas-Cooled Reactor (AGR) fuel qualification program. A representive coated fuel particle with an 235 U enrichment of 19.8 wt% was used in this analysis. The fuel burnup analysis tool used to perform the neutronics study reported herein, couples the Monte Carlo transport code MCNP, with the radioactive decay and burnup code ORIGEN2. The fuel burnup methodology known as Monte-Carlo with ORIGEN2 (MCWO) was used to evaluate the AGR experiment assembly and demonstrate compliance with ATR safety requirements. For the AGR graphite fuel compacts, the MCWO-calculated fission power density (FPD) due to neutron fission in 235 U is an important design parameter. One of the more important AGR fuel testing requirements is to maintain the peak fuel compact temperature close to 1250degC throughout the proposed irradiation campaign of 550 effective full power days (EFPDs). Based on the MCWO-calculated FPD, a fixed gas gap size was designed to allow regulation of the fuel compact temperatures throughout the entire fuel irradiation campaign by filling the gap with a mixture of helium and neon gases. The chosen fixed gas gap can only regulate the peak fuel compact temperature in the desired range during the irradiation test if the ratio of the peak power density to the time-dependent low power density (P/T) at 550 EFPDs is less than 2.5. However, given the near constant neutron flux within the ATR driver core and the depletion of 235 U

  4. Testing Low-Energy, High-Power Energy Storage Alternatives in a Full-Hybrid Vehicle (Presentation)

    Energy Technology Data Exchange (ETDEWEB)

    Cosgrove, J.; Gonger, J.

    2014-01-01

    Automakers have been mass producing hybrid electric vehicles (HEVs) for well over a decade, and the technology has proven to be very effective at reducing per-vehicle gasoline use. However, the battery cost in HEVs contribute to higher incremental cost of HEVs (a few thousand dollars) than the cost of comparable conventional vehicles, which has limited HEV market penetration. Significant cost reductions/performance improvements to the energy storage system (ESS) can improve the vehicle-level cost vs. benefit relationship for HEVs. Such an improvement could lead to larger HEV market penetration and greater aggregate gasoline savings. After significant analysis by the National Renewable Energy Laboratory (NREL), the United States Advanced Battery Consortium (USABC) and Department of Energy (DOE) Energy Storage program suggested a new set of requirements for ESS for power-assist HEVs for cost reduction without impacting performance and fuel economy significantly. With support from DOE, NREL has developed an HEV test platform for in-vehicle performance and fuel economy validation testing of the hybrid system using such LEESS devices. This poster will describe development of the LEESS HEV test platform, and LEESS laboratory as well as in-vehicle evaluation results. The first LEESS technology tested was lithium-ion capacitors (LICs) - i.e., asymmetric electrochemical energy storage devices possessing one electrode with battery-type characteristics (lithiated graphite) and one with ultracapacitor-type characteristics (carbon). We will discuss the performance and fuel saving results with LIC with comparison with original NiMH battery.

  5. Qualitative analysis of the Clock Drawing Test by educational level and cognitive profile

    Directory of Open Access Journals (Sweden)

    Aline Teixeira Fabricio

    2014-04-01

    Full Text Available The use of a qualitative scale for the Clock Drawing Test (CDT may add information about the pattern of errors committed. Objective: To translate and adapt the Modified Qualitative Error Analysis of Rouleau into Brazilian Portuguese and to examine the pattern of errors according to educational level and cognitive profile. Method: 180 adults (47-82 years completed the CDT. Participants were stratified into age and educational levels and separated between those with and without changes in cognitive screening tests (Mini-Mental State Examination, Verbal Fluency. Results: No significant differences were found in CDT scores among age groups. Among participants without cognitive impairment, those with lower education often presented graphic difficulties, conceptual deficits and spatial deficits. Participants with cognitive deficits, demonstrated more frequently conceptual and spatial errors. Conclusion: The qualitative analysis of the CDT may contribute to the identification of cognitive changes. Education level has to be taken into consideration during the analysis.

  6. Integration, Testing, and Validation of a Small Hybrid-Electric Remotely-Piloted Aircraft

    Science.gov (United States)

    2012-03-22

    unmanned aircraft offers the capability to unrelentingly pursue a target in a way the stamina of a human pilot simply cannot match. Unmanned systems can...electricity in these examples is provided by batteries, other hybrid-electric systems use generators, solar cells , or even hydrogen fuel cells ... cells , or solar panels. Throughout this paper, HE-RPA will refer specifically to the battery and fossil fuel combination. Usually, the secondary energy

  7. Design and Testing of Digitally Manufactured Paraffin Acrylonitrile-Butadiene-Styrene Hybrid Rocket Motors

    OpenAIRE

    McCulley, Jonathan M.

    2013-01-01

    This research investigates the application of additive manufacturing techniques for fabricating hybrid rocket fuel grains composed of porous Acrylonitrile-butadiene-styrene impregnated with paraffin wax. The digitally manufactured ABS substrate provides mechanical support for the paraffin fuel material and serves as an additional fuel component. The embedded paraffin provides an enhanced fuel regression rate while having no detrimental effect on the thermodynamic burn properties of the fuel g...

  8. On-chip transduction of nucleic acid hybridization using spatial profiles of immobilized quantum dots and fluorescence resonance energy transfer.

    Science.gov (United States)

    Tavares, Anthony J; Noor, M Omair; Vannoy, Charles H; Algar, W Russ; Krull, Ulrich J

    2012-01-03

    The glass surface of a glass-polydimethylsiloxane (PDMS) microfluidic channel was modified to develop a solid-phase assay for quantitative determination of nucleic acids. Electroosmotic flow (EOF) within channels was used to deliver and immobilize semiconductor quantum dots (QDs), and electrophoresis was used to decorate the QDs with oligonucleotide probe sequences. These processes took only minutes to complete. The QDs served as energy donors in fluorescence resonance energy transfer (FRET) for transduction of nucleic acid hybridization. Electrokinetic injection of fluorescent dye (Cy3) labeled oligonucleotide target into a microfluidic channel and subsequent hybridization (within minutes) provided the proximity for FRET, with emission from Cy3 being the analytical signal. The quantification of target concentration was achieved by measurement of the spatial length of coverage by target along a channel. Detection of femtomole quantities of target was possible with a dynamic range spanning an order of magnitude. The assay provided excellent resistance to nonspecific interactions of DNA. Further selectivity of the assay was achieved using 20% formamide, which allowed discrimination between a fully complementary target and a 3 base pair mismatch target at a contrast ratio of 4:1. © 2011 American Chemical Society

  9. Profile of Students' Creative Thinking Skills on Quantitative Project-Based Protein Testing using Local Materials

    Directory of Open Access Journals (Sweden)

    D. K. Sari

    2017-04-01

    Full Text Available The purpose of this study is to obtain a profile of students’ creative thinking skills on quantitative project-based protein testing using local materials. Implementation of the research is using quasi-experimental method pre-test post-test control group design with 40 students involved in Biochemistry lab. The research instrument is pre-test and post-test using creative thinking skills in the form of description and students’ questionnaire. The analysis was performed with SPSS 22.0 program to see the significance normality, U Mann-Whitney test for nonparametric statistics, N-Gain score, and the percentage of student responses to the practicum performed. The research result shows that the pretest rate in the experimental group is 8.25 while in the control group is 6.90. After attending a project-based practicum with local materials, the experimental group obtained the mean of posttest is 37.55 while in control class is 11.18. The students’ improvement on creative thinking skills can be seen from the average of N-Gain in the experimental class with 0.32 (medium category and in the control category with 0.05 (low category. The experimental and control class have different creative thinking skills significantly different fluency, flexibility, novelty, and detail. It can be concluded that quantitative project-based protein testing using local materials can improve students’ creative thinking skills. 71% of total students feel that quantitative project-based protein testing using local materials make them more creative in doing a practicum in the laboratory.

  10. Development and application of an actively controlled hybrid proton exchange membrane fuel cell - Lithium-ion battery laboratory test-bed based on off-the-shelf components

    Energy Technology Data Exchange (ETDEWEB)

    Yufit, V.; Brandon, N.P. [Dept. Earth Science and Engineering, Imperial College, London SW7 2AZ (United Kingdom)

    2011-01-15

    The use of commercially available components enables rapid prototyping and assembling of laboratory scale hybrid test-bed systems, which can be used to evaluate new hybrid configurations. The development of such a test-bed using an off-the-shelf PEM fuel cell, lithium-ion battery and DC/DC converter is presented here, and its application to a hybrid configuration appropriate for an unmanned underwater vehicle is explored. A control algorithm was implemented to regulate the power share between the fuel cell and the battery with a graphical interface to control, record and analyze the electrochemical and thermal parameters of the system. The results demonstrate the applicability of the test-bed and control algorithm for this application, and provide data on the dynamic electrical and thermal behaviour of the hybrid system. (author)

  11. Automated processing of fluorescence in-situ hybridization slides for HER2 testing in breast and gastro-esophageal carcinomas.

    Science.gov (United States)

    Tafe, Laura J; Allen, Samantha F; Steinmetz, Heather B; Dokus, Betty A; Cook, Leanne J; Marotti, Jonathan D; Tsongalis, Gregory J

    2014-08-01

    HER2 fluorescence in-situ hybridization (FISH) is used in breast and gastro-esophageal carcinoma for determining HER2 gene amplification and patients' eligibility for HER2 targeted therapeutics. Traditional manual processing of the FISH slides is labor intensive because of multiple steps that require hands on manipulation of the slides and specifically timed intervals between steps. This highly manual processing also introduces inter-run and inter-operator variability that may affect the quality of the FISH result. Therefore, we sought to incorporate an automated processing instrument into our FISH workflow. Twenty-six cases including breast (20) and gastro-esophageal (6) cancer comprising 23 biopsies and three excision specimens were tested for HER2 FISH (Pathvysion, Abbott) using the Thermobrite Elite (TBE) system (Leica). Up to 12 slides can be run simultaneously. All cases were previously tested by the Pathvysion HER2 FISH assay with manual preparation. Twenty cells were counted by two observers for each case; five cases were tested on three separate runs by different operators to evaluate the precision and inter-operator variability. There was 100% concordance in the scoring between the manual and TBE methods as well as among the five cases that were tested on three runs. Only one case failed due to poor probe hybridization. In total, seven cases were positive for HER2 amplification (HER2:CEP17 ratio >2.2) and the remaining 19 were negative (HER2:CEP17 ratio <1.8) utilizing the 2007 ASCO/CAP scoring criteria. Due to the automated denaturation and hybridization, for each run, there was a reduction in labor of 3.5h which could then be dedicated to other lab functions. The TBE is a walk away pre- and post-hybridization system that automates FISH slide processing, improves work flow and consistency and saves approximately 3.5h of technologist time. The instrument has a small footprint thus occupying minimal counter space. TBE processed slides performed

  12. A hybrid model for combining case-control and cohort studies in systematic reviews of diagnostic tests

    Science.gov (United States)

    Chen, Yong; Liu, Yulun; Ning, Jing; Cormier, Janice; Chu, Haitao

    2014-01-01

    Systematic reviews of diagnostic tests often involve a mixture of case-control and cohort studies. The standard methods for evaluating diagnostic accuracy only focus on sensitivity and specificity and ignore the information on disease prevalence contained in cohort studies. Consequently, such methods cannot provide estimates of measures related to disease prevalence, such as population averaged or overall positive and negative predictive values, which reflect the clinical utility of a diagnostic test. In this paper, we propose a hybrid approach that jointly models the disease prevalence along with the diagnostic test sensitivity and specificity in cohort studies, and the sensitivity and specificity in case-control studies. In order to overcome the potential computational difficulties in the standard full likelihood inference of the proposed hybrid model, we propose an alternative inference procedure based on the composite likelihood. Such composite likelihood based inference does not suffer computational problems and maintains high relative efficiency. In addition, it is more robust to model mis-specifications compared to the standard full likelihood inference. We apply our approach to a review of the performance of contemporary diagnostic imaging modalities for detecting metastases in patients with melanoma. PMID:25897179

  13. Sensitization Profile to Allergens in Patients Using Multi-Test II

    Science.gov (United States)

    Maniglia, Sergio Fabricio; Tsuru, Fernanda Miyoko; Santos, Victor Carvalho dos; Ueda, Denis Massatsugu

    2014-01-01

    Introduction Medical intervention in allergies has broadened its perspective, also focusing in the quality of life of patients. Patients are instructed, before using pharmacotherapy agents, to avoid the causal agent. Objective This study aims to analyze the sensitization profile of patients with allergic complaints and identify possible characteristics specific to each age group and gender. Methods A descriptive cross-sectional study included data collected from medical records (from Multi-Test II database, Lincoln Diagnostics Inc. Decatur, Illinois) of 1,912 patients who underwent skin prick test from March to October 2013. Patients were organized and analyzed according to gender, age, and results of the allergens subtypes tested. Results The study was composed of 1,912 patients (60% male and 40% female) of ages between 3 and 87 years. Positive tests were more prevalent in quantity and intensity with the mites Dermatophagoides pteronyssinus and Dermatophagoides farinae, each with 60% of the total analyzed. In second place were pollens, especially Dactylis glomerata and Festuca pratensis. Conclusion The female and male sexes were equally atopic. Fungi and epithelia of dog and cat were not considered potential aeroallergens that could cause symptoms. However, mites are common in Paraná, Brazil. Further studies regarding the pollens are needed, as this study result diverged from the literature. PMID:25992129

  14. Reactor protection system software test-case selection based on input-profile considering concurrent events and uncertainties

    International Nuclear Information System (INIS)

    Khalaquzzaman, M.; Lee, Seung Jun; Cho, Jaehyun; Jung, Wondea

    2016-01-01

    Recently, the input-profile-based testing for safety critical software has been proposed for determining the number of test cases and quantifying the failure probability of the software. Input-profile of a reactor protection system (RPS) software is the input which causes activation of the system for emergency shutdown of a reactor. This paper presents a method to determine the input-profile of a RPS software which considers concurrent events/transients. A deviation of a process parameter value begins through an event and increases owing to the concurrent multi-events depending on the correlation of process parameters and severity of incidents. A case of reactor trip caused by feedwater loss and main steam line break is simulated and analyzed to determine the RPS software input-profile and estimate the number of test cases. The different sizes of the main steam line breaks (e.g., small, medium, large break) with total loss of feedwater supply are considered in constructing the input-profile. The uncertainties of the simulation related to the input-profile-based software testing are also included. Our study is expected to provide an option to determine test cases and quantification of RPS software failure probability. (author)

  15. Test facilities for hybrid and electric drive trains; Stazione di prova sistemi di trazione ibridi ed elettrici

    Energy Technology Data Exchange (ETDEWEB)

    Bernardini, G.; Ciancia, A.; De Andreis, L.; Pagni, G.; Pede, G.; Rossi, E.; Vellone, R. [ENEA, Centro Ricerche Casaccia, Rome (Italy). Dip. Energia

    1998-12-31

    ENEA (Italian National Agency for New Technologies, Energy and the Environment) is conducting a large research and development programme on innovative vehicles with high energy efficiency and low environmental impact. In particular conducts activities on electric and hybrid vehicles. Testing and evaluation activities play a strong role in this programme. A complete characterization chain has been then defined and set up with a network of facilities which covers main testing needs for single components, subsystems and complete vehicles, in simulated and real operating conditions. The test facility which has been realised is able to experiment and fully characterise complete drive-trains (and subsystems) for pure electric and hybrid vehicles. It is composed by a different section for each subsystem: 1) power generation; 2) energy storage and management; 3) driving motors. Each section acts as an experimental island, able to operate alone or jointly with the other sections. In fact, all the sections are remotely controlled and managed in order to create different assembly of the drive-train. The facility has been sized to allow the testing of drive-trains and subsystems of small and medium-sized vehicles (up to minibuses), but an extension to larger vehicles is possible. During 1996 and part of 1997 the Drive train Test Facility has been completed and made operative. This paper mainly presents the final configurations of these novel testing systems with peculiar features and characteristics. [Italiano] ENEA (Ente Nazionale per le nuove tecnologie, l`Energia e l`Ambiente) sta conducendo un vasto programma di ricerca e sviluppo sui veicoli innovativi ad alto rendimento energetico e basso impatto ambientale.

  16. Testing parasite "intimacy": the whipworm Trichuris muris in the European house mouse hybrid zone

    Czech Academy of Sciences Publication Activity Database

    Wasimuddin, Wasimuddin; Bryja, Josef; Ribas, A.; Baird, Stuart J. E.; Piálek, Jaroslav; Goüy de Bellocq, Joëlle

    2016-01-01

    Roč. 6, č. 9 (2016), s. 2688-2701 ISSN 2045-7758 R&D Projects: GA ČR GA206/08/0640; GA MŠk EE2.3.35.0026; GA MŠk EE2.3.20.0303; GA ČR(CZ) GA16-20049S Institutional support: RVO:68081766 Keywords : Hybrid zones * Mus musculus * parasite life history traits * phylogeography * population structure Subject RIV: EG - Zoology OBOR OECD: Ecology Impact factor: 2.440, year: 2016

  17. Energetic Profile of the Basketball Exercise Simulation Test in Junior Elite Players.

    Science.gov (United States)

    Latzel, Richard; Hoos, Olaf; Stier, Sebastian; Kaufmann, Sebastian; Fresz, Volker; Reim, Dominik; Beneke, Ralph

    2017-11-28

    To analyze the energetic profile of the basketball exercise simulation test (BEST). 10 male elite junior basketball players (age: 15.5±0.6yrs, height: 180±9cm, body mass: 66.1±11.2kg) performed a modified BEST (20 circuits consisting of jumping, sprinting, jogging, shuffling, and short breaks) simulating professional basketball game play. Circuit time, sprint time, sprint decrement, oxygen uptake (VO2), heart rate (HR), and blood lactate concentration (BLC) were obtained. Metabolic energy and metabolic power above rest (W tot , P tot ) as well as energy share in terms of aerobic (W aer ), glycolytic (W blc ), and high energy phosphates (W PCr ) were calculated from VO2 during exercise, net lactate production, and the fast component of post-exercise VO2 kinetics, respectively. W aer , W blc , and W PCr reflect 89±2%, 5±1%, and 6±1% of total energy needed, respectively. Assuming an aerobic replenishment of PCr energy stores during short breaks, the adjusted energy share yielded W aer : 66±4%, W blc : 5±1%, and W PCr : 29±1%. W aer and W PCr were negatively correlated (-0.72, -0.59) with sprint time, which was not the case for W blc . Consistent with general findings on energy system interaction during repeated high intensity exercise bouts, the intermittent profile of the BEST relies primarily on aerobic energy combined with repetitive supplementation by anaerobic utilization of high energy phosphates.

  18. A beam-profile monitor for the BNL Accelerator Test Facility (ATF)

    International Nuclear Information System (INIS)

    Russell, D.P.; McDonald, K.T.

    1989-01-01

    A beam-profile monitor has been designed to diagnose the 5-MeV high-brightness electron beam from the rf gun of the BNL Accelerator Test Facility (ATF). The monitor consists of a phosphor screen viewed by a CCD camera. The video images are digitized and stored by a framegrabber and analyzed by an IBM PC-AT to extract the emittance. Details of the hardware configuration are presented, along with the spatial resolution of the system measured as a function of phosphor-screen thickness. The strategies which will be used to measure the transverse and longitudinal emittances are briefly mentioned. The system should be capable of measuring a transverse geometric emittance of around 1 mm-mrad, as will be typical of the ATF beam. 6 refs., 2 figs

  19. Fabrication and Performance Test of Aluminium Alloy-Rice Husk Ash Hybrid Metal Matrix Composite as Industrial and Construction Material

    Directory of Open Access Journals (Sweden)

    Md. Rahat Hossain

    2017-12-01

    Full Text Available Aluminium matrix composites (AMCs used extensively in various engineering fields due to their exceptional mechanical properties. In this present study, aluminium matrix composites (AMCs such as aluminium alloy (A356 reinforced with rice husk ash particles (RHA are made to explore the possibilities of reinforcing aluminium alloy. The stir casting method was applied to produce aluminium alloy (A356 reinforced with various amounts of (2%, 4%, and 6% rice husk ash (RHA particles. Physical treatment was carried out before the rice husk ash manufacturing process. The effect of mechanical strength of the fabricated hybrid composite was investigated. Therefore, impact test, tensile stress, compressive stress, and some other tests were carried out to analyse the mechanical properties. From the experimental results, it was found that maximum tensile, and compressive stress were found at 6% rice husk ash (RHA and aluminium matrix composites (AMCs. In future, the optimum percentages of rice husk ash (RHA to fabricate the hybrid composites will be determined. Also, simulation by finite element method (FEM will be applied for further investigation.

  20. Comparison of RNA expression profiles on generations of Porphyra yezoensis (Rhodophyta, based on suppression subtractive hybridization (SSH

    Directory of Open Access Journals (Sweden)

    Shen Songdong

    2011-10-01

    Full Text Available Abstract Background Porphyra yezoensis Ueda is one of the most important edible seaweed, with a dimorphic life cycle which consists of gametophyte as macroscopical blade and sporophyte as microscopic filamentous. Conspicuous differences exist in the two generations, such as morphology, cell structure, biochemistry, physiology, and so on. The developmental process of Porphyra yezoensis has been studied thoroughly, but the mechanism is still ambiguous and few studies on genetic expression have been carried out. In this study, the suppression subtractive hybridization (SSH method conducted to generate large-scale expressed sequence tags (EST is designed to identify gene candidates related to the morphological and physiological differences between the gametophytic and sporophytic generations of Porphyra yezoensis Ueda. Findings Each 300 clones of sporophyte and gametophyte cells were dipped onto the membrane for hybridization. The result of dot-blot suggested there were 222 positive clones in gametophyte library and 236 positive clones in sporophyte library. 383 positive clones of strongest signals had been sequenced, and 191 EST sequences of gametophyte and 192 of sporophyte were obtained. A total of 196 genes were obtained, within which 104 genes were identified from the gametophyte and 92 from the sporophyte. Thirty-nine genes of the gametophyte and 62 genes of the sporophyte showed sequence similarity to those genes with known or putative functions which were classified according to their putative biological roles and molecular functions. The GO annotation showed about 58% of the cellular component of sporophyte and gametophyte cells were mainly located in cytoplasm and nucleus. The special genes were located in Golgi apparatus, and high expression in plastid, ribosome and endoplasmic reticulum. The main biological functions of gametophyte cells contributed to DNA repair/replication, carbohydrate metabolism, transport and transcription

  1. Seabed resident event driven profiling system (SREP). Concept, design and tests

    Digital Repository Service at National Institute of Oceanography (India)

    Mascarenhas, A.A.M.Q.; Afzulpurkar, S.; Maurya, P.K.; Fernandes, L.; Madhan, R.; Desa, E.S.; Dabolkar, N.A.; Navelkar, G.S.; Naik, L.; Shetye, V.G.; Shetty, N.B.; Prabhudesai, S.P.; Nagvekar, S.; Vimalakumari, D.

    The seabed resident event driven profiling system (SREP) described here offers a novel, optimized approach to profiling in coastal waters from seabed to sea surface during the rough seas encountered in the southwest monsoon season (June...

  2. BEAP profiles as rapid test system for status analysis and early detection of process incidents in biogas plants.

    Science.gov (United States)

    Refai, Sarah; Berger, Stefanie; Wassmann, Kati; Hecht, Melanie; Dickhaus, Thomas; Deppenmeier, Uwe

    2017-03-01

    A method was developed to quantify the performance of microorganisms involved in different digestion levels in biogas plants. The test system was based on the addition of butyrate (BCON), ethanol (ECON), acetate (ACON) or propionate (PCON) to biogas sludge samples and the subsequent analysis of CH 4 formation in comparison to control samples. The combination of the four values was referred to as BEAP profile. Determination of BEAP profiles enabled rapid testing of a biogas plant's metabolic state within 24 h and an accurate mapping of all degradation levels in a lab-scale experimental setup. Furthermore, it was possible to distinguish between specific BEAP profiles for standard biogas plants and for biogas reactors with process incidents (beginning of NH 4 + -N inhibition, start of acidification, insufficient hydrolysis and potential mycotoxin effects). Finally, BEAP profiles also functioned as a warning system for the early prediction of critical NH 4 + -N concentrations leading to a drop of CH 4 formation.

  3. Plug-in hybrid vehicle GHG impacts in California: Integrating consumer-informed recharge profiles with an electricity-dispatch model

    International Nuclear Information System (INIS)

    Axsen, Jonn; Kurani, Kenneth S.; McCarthy, Ryan; Yang, Christopher

    2011-01-01

    This paper explores how Plug-in Hybrid Vehicles (PHEVs) may reduce source-to-wheel Greenhouse Gas (GHG) emissions from passenger vehicles. The two primary advances are the incorporation of (1) explicit measures of consumer interest in and potential use of different types of PHEVs and (2) a model of the California electricity grid capable of differentiating hourly and seasonal GHG emissions by generation source. We construct PHEV emissions scenarios to address inherent relationships between vehicle design, driving and recharging behaviors, seasonal and time-of-day variation in GHG-intensity of electricity, and total GHG emissions. A sample of 877 California new vehicle buyers provide data on driving, time of day recharge access, and PHEV design interests. The elicited data differ substantially from the assumptions used in previous analyses. We construct electricity demand profiles scaled to one million PHEVs and input them into an hourly California electricity supply model to simulate GHG emissions. Compared to conventional vehicles, consumer-designed PHEVs cut marginal (incremental) GHG emissions by more than one-third in current California energy scenarios and by one-quarter in future energy scenarios-reductions similar to those simulated for all-electric PHEV designs. Across the emissions scenarios, long-term GHG reductions depends on reducing the carbon intensity of the grid. - Research highlights: → We estimate California Plug-in Hybrid Vehicle (PHEV) GHGs using consumer data and an electricity supply model. → Consumer-designed (mostly 'blended') PHEVs can reduce GHG emissions compared to conventional vehicles. → These PHEVs can also reduce GHG emissions relative to 'all-electric' PHEV designs. → 'All-electric' designs may further reduce GHG emissions as electricity carbon intensity falls. → Ranking of GHG savings from off-peak versus daytime charging scenarios depends on electricity carbon intensity.

  4. Ranking nano-enabled hybrid media for simultaneous removal of contaminants with different chemistries: Pseudo-equilibrium sorption tests versus column tests.

    Science.gov (United States)

    Custodio, Tomas; Garcia, Jose; Markovski, Jasmina; McKay Gifford, James; Hristovski, Kiril D; Olson, Larry W

    2017-12-15

    The underlying hypothesis of this study was that pseudo-equilibrium and column testing conditions would provide the same sorbent ranking trends although the values of sorbents' performance descriptors (e.g. sorption capacity) may vary because of different kinetics and competition effects induced by the two testing approaches. To address this hypothesis, nano-enabled hybrid media were fabricated and its removal performances were assessed for two model contaminants under multi-point batch pseudo-equilibrium and continuous-flow conditions. Calculation of simultaneous removal capacity indices (SRC) demonstrated that the more resource demanding continuous-flow tests are able to generate the same performance rankings as the ones obtained by conducing the simpler pseudo-equilibrium tests. Furthermore, continuous overlap between the 98% confidence boundaries for each SRC index trend, not only validated the hypothesis that both testing conditions provide the same ranking trends, but also pointed that SRC indices are statistically the same for each media, regardless of employed method. In scenarios where rapid screening of new media is required to obtain the best performing synthesis formulation, use of pseudo-equilibrium tests proved to be reliable. Considering that kinetics induced effects on sorption capacity must not be neglected, more resource demanding column test could be conducted only with the top performing media that exhibit the highest sorption capacity. Copyright © 2017 Elsevier B.V. All rights reserved.

  5. Avoiding pitfalls in molecular genetic testing: case studies of high-resolution array comparative genomic hybridization testing in the definitive diagnosis of Mowat-Wilson syndrome.

    Science.gov (United States)

    Kluk, Michael Joseph; An, Yu; James, Philip; Coulter, David; Harris, David; Wu, Bai-Lin; Shen, Yiping

    2011-05-01

    The molecular testing options available for the diagnosis of genetic disorders are numerous and include a variety of different assay platforms. The consultative input of molecular pathologists and cytogeneticists, working closely with the ordering clinicians, is often important for definitive diagnosis. Herein, we describe two patients who had long histories of unexplained signs and symptoms with a high clinical suspicion of an underlying genetic etiology. Initial molecular testing in both cases was negative, but the application of high-resolution array comparative genomic hybridization technology lead to definitive diagnosis in both cases. We summarize the clinical findings and molecular testing in each case, discuss the differential diagnoses, and review the clinical and pathological findings of Mowat-Wilson syndrome. This report highlights the importance for those involved in molecular testing to know the nature of the underlying genetic abnormalities associated with the suspected diagnosis, to recognize the limitations of each testing platform, and to persistently pursue repeat testing using high-resolution technologies when indicated. This concept is applicable to both germline and somatic molecular genetic testing. Copyright © 2011 American Society for Investigative Pathology and the Association for Molecular Pathology. Published by Elsevier Inc. All rights reserved.

  6. A Comparative Study of the Analysis, Numerical Modelling and Experimental Test on a Sandwich Panel with Plane and Profiled Facings

    Directory of Open Access Journals (Sweden)

    Raluca Hohan

    2010-01-01

    Full Text Available Sandwich panels are remarkable products because they can be as strong as a solid material but with less weight. The analysis that is required to predict the stresses and deflections in panels with flat or lightly profiled facings is that of conventional beam theory but with the addition of shear deformation. Knowing that the profiled sheets bring an increase of the flexural stiffness, formulas showing the calculus of a panel with flat and profiled facings are established. A comparison between the results of a mathematical calculus, an experimental test and a numerical modelling is provided.

  7. Testing and Modeling Fuel Regression Rate in a Miniature Hybrid Burner

    Directory of Open Access Journals (Sweden)

    Luciano Fanton

    2012-01-01

    Full Text Available Ballistic characterization of an extended group of innovative HTPB-based solid fuel formulations for hybrid rocket propulsion was performed in a lab-scale burner. An optical time-resolved technique was used to assess the quasisteady regression history of single perforation, cylindrical samples. The effects of metalized additives and radiant heat transfer on the regression rate of such formulations were assessed. Under the investigated operating conditions and based on phenomenological models from the literature, analyses of the collected experimental data show an appreciable influence of the radiant heat flux from burnt gases and soot for both unloaded and loaded fuel formulations. Pure HTPB regression rate data are satisfactorily reproduced, while the impressive initial regression rates of metalized formulations require further assessment.

  8. Optimization of the stand for test of hybrid rocket engines of solid fuel

    Directory of Open Access Journals (Sweden)

    Zolotorev Nikolay

    2017-01-01

    Full Text Available In the paper the laboratory experimental stand of the hybrid rocket engine of solid fuel to study ballistic parameters of the engine at burning of high-energy materials in flow of hot gas is presented. Mixture of air with nitrogen with a specified content of active oxygen is used as a gaseous oxidizer. The experimental stand has modular design and consists of system of gas supply, system of heating of gas, system for monitoring gas parameters, to which a load cell with a model engine was connected. The modular design of the stand allows to change its configuration under specific objective. This experimental stand allows to conduct a wide range of the pilot studies at interaction of a hot stream of gas with samples high-energy materials.

  9. COMPARISON OF A HEAD MOUNTED IMPACT MEASUREMENT DEVICE TO THE HYBRID III ANTHROPOMORPHIC TESTING DEVICE IN A CONTROLLED LABORATORY SETTING.

    Science.gov (United States)

    Schussler, Eric; Stark, David; Bolte, John H; Kang, Yun Seok; Onate, James A

    2017-08-01

    Reports estimate that 1.6 to 3.8 million cases of concussion occur in sports and recreation each year in the United States. Despite continued efforts to reduce the occurrence of concussion, the rate of diagnosis continues to increase. The mechanisms of concussion are thought to involve linear and rotational head accelerations and velocities. One method of quantifying the kinematics experienced during sport participation is to place measurement devices into the athlete's helmet or directly on the athlete's head. The purpose of this research to determine the accuracy of a head mounted device for measuring the head accelerations experienced by the wearer. This will be accomplished by identifying the error in Peak Linear Acceleration (PLA), Peak Rotational Acceleration (PRA) and Peak Rotational Velocity (PRV) of the device. Laboratory study. A helmeted Hybrid III 50th percentile male headform was impacted via a pneumatic ram from the front, side, rear, front oblique and rear oblique at speeds from 1.5 to 5 m/s. The X2 Biosystems xPatch® (Seattle, WA) sensor was placed on the headform's right side at the approximate location of the mastoid process. Measures of PLA, PRA, PRV from the xPatch ® and Hybrid III were analyzed for Root Mean Square Error (RMSE), and Absolute and Relative Error (AE, RE). Seventy-six impacts were analyzed. All measures of correlation, fixed through the origin, were found to be strong: PLA R 2 =0.967 pstandard yet above the average error of testing devices in both PLA and PRA, but a low error in PRV. PLA measures from the xPatch® system demonstrated a high level of correlation with the PLA data from the Hybrid III mounted data collection system. 3.

  10. Transcriptional profiles of hybrid Eucalyptus genotypes with contrasting lignin content reveal that monolignol biosynthesis-related genes regulate wood composition

    Directory of Open Access Journals (Sweden)

    Tomotaka eShinya

    2016-04-01

    Full Text Available Eucalyptus species constitutes the most widely planted hardwood trees in temperate and subtropical regions. In this study, we compared the transcript levels of genes involved in lignocellulose formation such as cellulose, hemicellulose and lignin biosynthesis in two selected three-year old hybrid Eucalyptus (Eucalyptus urophylla x E. grandis genotypes (AM063 and AM380 that have different lignin content. AM063 and AM380 had 20.2 and 35.5% of Klason lignin content and 59.0% and 48.2%, -cellulose contents, respectively. We investigated the correlation between wood properties and transcript levels of wood formation-related genes using RNA-seq with total RNAs extracted from developing xylem tissues at a breast height. Transcript levels of cell wall construction genes such as cellulose synthase (CesA and sucrose synthase (SUSY were almost the same in both genotypes. However, AM063 exhibited higher transcript levels of UDP-glucose pyrophosphorylase (UGP and xyloglucan endotransglucoxylase (XTH than those in AM380. Most monolignol biosynthesis- related isozyme genes showed higher transcript levels in AM380. These results indicate monolignol biosynthesis-related genes may regulate wood composition in Eucalyptus. Flavonoids contents were also observed at much higher levels in AM380 as a result of the elevated transcript levels of common phenylpropanoid pathway genes, phenylalanine ammonium lyase (PAL, cinnamate-4-hydroxylase (C4H and 4-coumarate-CoA ligase (4CL. Secondary plant cell wall formation is regulated by many transcription factors. We analyzed genes encoding NAC, WRKY, AP2/ERF and KNOX transcription factors and found higher transcript levels of these genes in AM380. We also observed increased transcription of some MYB and LIM domain transcription factors in AM380 compared to AM063. All these results show that genes related to monolignol biosynthesis may regulate the wood composition and help maintain the ratio of cellulose and lignin contents

  11. A theoretical and practical test of geographical profiling with serial vehicle theft in a U.K. context.

    Science.gov (United States)

    Tonkin, Matthew; Woodhams, Jessica; Bond, John W; Loe, Trudy

    2010-01-01

    Geographical profiling is an investigative methodology sometimes employed by the police to predict the residence of an unknown offender from the locations of his/her crimes. The validity of geographical profiling, however, has not been fully explored for certain crime types. This study, therefore, presents a preliminary test of the potential for geographical profiling with a sample of 145 serial vehicle thieves from the U.K. The behavioural assumptions underlying geographical profiling (distance decay and domocentricity) are tested and a simple practical test of profiling using the spatial mean is presented. There is evidence for distance decay but not domocentricity among the spatial behaviour of car thieves from the U.K. A degree of success was achieved when applying the spatial mean on a case-by-case basis. The level of success varied, however, and neither series length in days nor number of crimes could account for the variation. The findings question previously held assumptions regarding geographical profiling and have potential theoretical and practical implications for the study and investigation of vehicle theft in the U.K. 2009 John Wiley & Sons, Ltd.

  12. Resistive flux saving and current profile control during lower hybrid waves assisted current rise in TORE SUPRA

    International Nuclear Information System (INIS)

    van Houtte, D.; Hoang, G.T.; Joffrin, E.; Lecoustey, P.; Moreau, D.; Parlange, F.; Tonon, G.; Vallet, J.C.

    1992-01-01

    Resistive flux saving at densities n e = (1 - 2) x 10 19 m -3 has been studied. High flux saving efficiency (0.7 x 10 13 Wb/J/m -1 ) can be achieved for a low rf power (P LH = 0.5 MW) due to the beneficial effect of the electric field on the suprathermal electrons. However for power higher than 1 MW, the efficiency is 0.25 x 10 13 Wb/J/m -1 . This flux saving efficiency is comparable to the one obtained during the flat top phase. The application of the LH power during a low density current ramp-up tends to peak the electron temperature and current density profiles. The rf power level, the parallel wavenumber and the current ramp rate allow to control the trajectories of the plasma discharges during the current rise inside the MHD stable domain

  13. Bacterial Cytological Profiling (BCP as a Rapid and Accurate Antimicrobial Susceptibility Testing Method for Staphylococcus aureus

    Directory of Open Access Journals (Sweden)

    D.T. Quach

    2016-02-01

    Full Text Available Successful treatment of bacterial infections requires the timely administration of appropriate antimicrobial therapy. The failure to initiate the correct therapy in a timely fashion results in poor clinical outcomes, longer hospital stays, and higher medical costs. Current approaches to antibiotic susceptibility testing of cultured pathogens have key limitations ranging from long run times to dependence on prior knowledge of genetic mechanisms of resistance. We have developed a rapid antimicrobial susceptibility assay for Staphylococcus aureus based on bacterial cytological profiling (BCP, which uses quantitative fluorescence microscopy to measure antibiotic induced changes in cellular architecture. BCP discriminated between methicillin-susceptible (MSSA and -resistant (MRSA clinical isolates of S. aureus (n = 71 within 1–2 h with 100% accuracy. Similarly, BCP correctly distinguished daptomycin susceptible (DS from daptomycin non-susceptible (DNS S. aureus strains (n = 20 within 30 min. Among MRSA isolates, BCP further identified two classes of strains that differ in their susceptibility to specific combinations of beta-lactam antibiotics. BCP provides a rapid and flexible alternative to gene-based susceptibility testing methods for S. aureus, and should be readily adaptable to different antibiotics and bacterial species as new mechanisms of resistance or multidrug-resistant pathogens evolve and appear in mainstream clinical practice.

  14. WWC Review of the Report "Interactive Online Learning on Campus: Testing MOOCs and Other Platforms in Hybrid Formats in the University System of Maryland." What Works Clearinghouse Single Study Review

    Science.gov (United States)

    What Works Clearinghouse, 2015

    2015-01-01

    In the 2014 study, "Interactive Online Learning on Campus: Testing MOOCs and Other Platforms in Hybrid Formats in the University System of Maryland," researchers examined the impact of using hybrid forms of interactive online learning in seven undergraduate courses across seven universities in Maryland. Hybrid forms of interactive online…

  15. 3D hybrid profile order technique in a single breath-hold 3D T2-weighted fast spin-echo sequence: Usefulness in diagnosis of small liver lesions.

    Science.gov (United States)

    Hirata, Kenichiro; Nakaura, Takeshi; Okuaki, Tomoyuki; Tsuda, Noriko; Taguchi, Narumi; Oda, Seitaro; Utsunomiya, Daisuke; Yamashita, Yasuyuki

    2018-01-01

    We compared the efficacy of three-dimensional (3D) isotropic T2-weighted fast spin-echo imaging using a 3D hybrid profile order technique with a single-breath-hold (3D-Hybrid BH) with a two-dimensional (2D) T2-weighted fast spin-echo conventional respiratory-gated (2D-Conventional RG) technique for visualising small liver lesions. This study was approved by our institutional review board. The requirement to obtain written informed consent was waived. Fifty patients with small (≤15mm) hepatocellular carcinomas (HCC) (n=26), or benign cysts (n=24), had undergone hepatic MRI including both 2D-Conventional RG and 3D-Hybrid BH. We calculated the signal-to-noise ratio (SNR) and tumour-to-liver contrast (TLC). The diagnostic performance of the two protocols was analysed. The image acquisition time was 89% shorter with the 3D-Hybrid BH than with 2D-Conventional RG. There was no significant difference in the SNR between the two protocols. The area under the curve (AUC) of the TLC was significantly higher on 3D-Hybrid BH than on 2D-Conventional RG. The 3D-Hybrid BH sequence significantly improved diagnostic performance for small liver lesions with a shorter image acquisition time without sacrificing accuracy. Copyright © 2017. Published by Elsevier B.V.

  16. Lower hybrid wave current ramp-up and plasma equilibrium

    International Nuclear Information System (INIS)

    Gong Xueyu

    1996-01-01

    Questions on lower hybrid driven current and plasma equilibrium are studied. With the induced electric field taken into account, a system of self-consistent equations is obtained. This theory has been applied to some moments of the current ramp-up phase for the Tokamak Engineering Test Breeder (TETB) to study the lower hybrid current drive and MHD equilibrium. So, better electron current and safety factor profiles are obtained

  17. Modelling and Experimental Testing of Hybrid Joints Made of: Aluminium Adherends, Adhesive Layers and Rivets for Aerospace Applications

    Directory of Open Access Journals (Sweden)

    Sadowski T.

    2017-09-01

    Full Text Available The contemporary demands in different branches of engineering require application of new multi-component materials and structural systems. Appropriately chosen joining technology can offer significant enhancement of structural system performance in terms of effectiveness, reliability, safety and other design criteria. The modern applications of complex joints are of great technological interest as they permit to combine and to enhance the individual effects of each kind of joint. This is of great importance for modern applications in different branches of engineering: aerospace, mechanical and civil. Therefore in this paper we will focus on the analysis of mechanical response of adhesive joint of aluminium strips reinforced by rivets. The aim of the paper is to investigate experimentally the mechanical behaviour of adhesive joint of aluminium strips reinforced by rivets for industrial applications in aerospace. The considered joint was subjected to uniaxial loading. The tests in this paper were performed for: • classical adhesive joint in order to investigate material parameters for numerical modelling of the hybrid joint • hybrid joining of the structural elements in order to investigate the reinforcement effect. The experiments with application of digital image ARAMIS system allowed for on-line monitoring of the deformation process of the considered joining elements. The particular distributions of displacement fields at the joint surface were estimated for any stage of loading process. Numerical modelling was performed for experimentally investigated specimens. The materials parameters, necessary for calculation, were estimated from experiments. FEA modelling was done with the help of ABAQUS code.

  18. Hybrid Computerized Adaptive Testing: From Group Sequential Design to Fully Sequential Design

    Science.gov (United States)

    Wang, Shiyu; Lin, Haiyan; Chang, Hua-Hua; Douglas, Jeff

    2016-01-01

    Computerized adaptive testing (CAT) and multistage testing (MST) have become two of the most popular modes in large-scale computer-based sequential testing. Though most designs of CAT and MST exhibit strength and weakness in recent large-scale implementations, there is no simple answer to the question of which design is better because different…

  19. Full Cryogenic Test of 600 A HTS Hybrid Current Leads for the LHC

    CERN Document Server

    Al-Mosawi, MK; Beduz, C; Ballarino, A; Yang, Y

    2007-01-01

    For full cryogenic test of CERN 600 A High Temperature Superconducting (HTS) current leads prior to integration into the Large Hadron Collider (LHC), a ded. facility has been designed, constructed and operated at the University of Southampton. The facility consists of purpose-built test cryostats, 20 K helium gas supply, helium gas flow and temperature control systems and quench protection system. Over 400 such leads have already been successfully tested and qualified for installation at CERN. This paper describes various design and operation aspects of the test facility and presents the detailed cryogenic test results of the CERN 600 A current leads, including steady state 20 K flow rates.

  20. Real Time Hybrid Model Predictive Control for the Current Profile of the Tokamak à Configuration Variable (TCV

    Directory of Open Access Journals (Sweden)

    Izaskun Garrido

    2016-08-01

    Full Text Available Plasma stability is one of the obstacles in the path to the successful operation of fusion devices. Numerical control-oriented codes as it is the case of the widely accepted RZIp may be used within Tokamak simulations. The novelty of this article relies in the hierarchical development of a dynamic control loop. It is based on a current profile Model Predictive Control (MPC algorithm within a multiloop structure, where a MPC is developed at each step so as to improve the Proportional Integral Derivative (PID global scheme. The inner control loop is composed of a PID-based controller that acts over the Multiple Input Multiple Output (MIMO system resulting from the RZIp plasma model of the Tokamak à Configuration Variable (TCV. The coefficients of this PID controller are initially tuned using an eigenmode reduction over the passive structure model. The control action corresponding to the state of interest is then optimized in the outer MPC loop. For the sake of comparison, both the traditionally used PID global controller as well as the multiloop enhanced MPC are applied to the same TCV shot. The results show that the proposed control algorithm presents a superior performance over the conventional PID algorithm in terms of convergence. Furthermore, this enhanced MPC algorithm contributes to extend the discharge length and to overcome the limited power availability restrictions that hinder the performance of advanced tokamaks.

  1. Differential profiling of volatile organic compound biomarker signatures utilizing a logical statistical filter-set and novel hybrid evolutionary classifiers

    Science.gov (United States)

    Grigsby, Claude C.; Zmuda, Michael A.; Boone, Derek W.; Highlander, Tyler C.; Kramer, Ryan M.; Rizki, Mateen M.

    2012-06-01

    A growing body of discoveries in molecular signatures has revealed that volatile organic compounds (VOCs), the small molecules associated with an individual's odor and breath, can be monitored to reveal the identity and presence of a unique individual, as well their overall physiological status. Given the analysis requirements for differential VOC profiling via gas chromatography/mass spectrometry, our group has developed a novel informatics platform, Metabolite Differentiation and Discovery Lab (MeDDL). In its current version, MeDDL is a comprehensive tool for time-series spectral registration and alignment, visualization, comparative analysis, and machine learning to facilitate the efficient analysis of multiple, large-scale biomarker discovery studies. The MeDDL toolset can therefore identify a large differential subset of registered peaks, where their corresponding intensities can be used as features for classification. This initial screening of peaks yields results sets that are typically too large for incorporation into a portable, electronic nose based system in addition to including VOCs that are not amenable to classification; consequently, it is also important to identify an optimal subset of these peaks to increase classification accuracy and to decrease the cost of the final system. MeDDL's learning tools include a classifier similar to a K-nearest neighbor classifier used in conjunction with a genetic algorithm (GA) that simultaneously optimizes the classifier and subset of features. The GA uses ROC curves to produce classifiers having maximal area under their ROC curve. Experimental results on over a dozen recognition problems show many examples of classifiers and feature sets that produce perfect ROC curves.

  2. Development of a Detonation Profile Test for Studying Aging Effects in LX-17

    International Nuclear Information System (INIS)

    Tran, T; Lewis, P; Tarver, C; Maienschein, J; Druce, R; Lee, R; Roeske, F

    2002-01-01

    A new small-scale Detonation Profile Test (DPT) is being developed to investigate aging effects on the detonation behavior of insensitive high explosives. The experiment involves initiating a small LX-17 cylindrical charge (12.7-19.1 mm diameter x 25.4-33 mm long) and measuring the velocity and curvature of the emerging detonation wave using a streak camera. Results for 12.7 mm diameter unconfined LX-17 charges show detonation velocity in the range between 6.79 and 7.06 km/s for parts up to 33 mm long. Since LX-17 can not sustain detonation at less than 7.3 km/s, these waves were definitely failing. Experiments with confined 12.7 mm diameter and unconfined 19.1 mm diameter samples showed wave velocities in the range of 7.4-7.6 km/s, values approaching steady state conditions at infinite diameter. Experiments with unconfined 19.1 mm diameter specimens are expected to provide reproducible and useful range of detonation parameters suitable for studying aging effects

  3. Development of a Detonation Profile Test for Studying Aging Effects in LX-17

    Energy Technology Data Exchange (ETDEWEB)

    Tran, T; Lewis, P; Tarver, C; Maienschein, J; Druce, R; Lee, R; Roeske, F

    2002-03-25

    A new small-scale Detonation Profile Test (DPT) is being developed to investigate aging effects on the detonation behavior of insensitive high explosives. The experiment involves initiating a small LX-17 cylindrical charge (12.7-19.1 mm diameter x 25.4-33 mm long) and measuring the velocity and curvature of the emerging detonation wave using a streak camera. Results for 12.7 mm diameter unconfined LX-17 charges show detonation velocity in the range between 6.79 and 7.06 km/s for parts up to 33 mm long. Since LX-17 can not sustain detonation at less than 7.3 km/s, these waves were definitely failing. Experiments with confined 12.7 mm diameter and unconfined 19.1 mm diameter samples showed wave velocities in the range of 7.4-7.6 km/s, values approaching steady state conditions at infinite diameter. Experiments with unconfined 19.1 mm diameter specimens are expected to provide reproducible and useful range of detonation parameters suitable for studying aging effects.

  4. An Application of CFD to Guide Forced Boundary-Layer Transition for Low-Speed Tests of a Hybrid Wing-Body Configuration

    Science.gov (United States)

    Luckring, James M.; Deere, Karen A.; Childs, Robert E.; Stremel, Paul M.; Long, Kurtis R.

    2016-01-01

    A hybrid transition trip-dot sizing and placement test technique was developed in support of recent experimental research on a hybrid wing-body configuration under study for the NASA Environmentally Responsible Aviation project. The approach combines traditional methods with Computational Fluid Dynamics. The application had three-dimensional boundary layers that were simulated with either fully turbulent or transitional flow models using established Reynolds-Averaged Navier-Stokes methods. Trip strip effectiveness was verified experimentally using infrared thermography during a low-speed wind tunnel test. Although the work was performed on one specific configuration, the process was based on fundamental flow physics and could be applicable to other configurations.

  5. Development and psychometric testing of a breast cancer patient-profiling questionnaire

    Directory of Open Access Journals (Sweden)

    Gorini A

    2015-06-01

    Full Text Available Alessandra Gorini,1,2 Ketti Mazzocco,1,2 Sara Gandini,2 Elisabetta Munzone,2 Gordon McVie,2 Gabriella Pravettoni1,2 1Department of Health Science, University of Milan, Milan, Italy; 2European Institute of Oncology, Milan, Italy Introduction: The advent of “personalized medicine” has been driven by technological advances in genomics. Concentration at the subcellular level of a patient's cancer cells has meant inevitably that the “person” has been overlooked. For this reason, we think there is an urgent need to develop a truly personalized approach focusing on each patient as an individual, assessing his/her unique mental dimensions and tailoring interventions to his/her individual needs and preferences. The aim of this study was to develop and test the psychometric properties of the ALGA-Breast Cancer (ALGA-BC, a new multidimensional questionnaire that assesses the breast cancer patient's physical and mental characteristics in order to provide physicians, prior to the consultation, with a patient's profile that is supposed to facilitate subsequent communication, interaction, and information delivery between the doctor and the patient. Methods: The specific validation processes used were: content and face validity, construct validity using factor analysis, reliability and internal consistency using test–retest reliability, and Cronbach's alpha correlation coefficient. The exploratory analysis included 100 primary breast cancer patients and 730 healthy subjects. Results: The exploratory factor analysis revealed eight key factors: global self-rated health, perceived physical health, anxiety, self-efficacy, cognitive closure, memory, body image, and sexual life. Test–retest reliability and internal consistency were good. Comparing patients with a sample of healthy subjects, we also observed a general ability of the ALGA-BC questionnaire to discriminate between the two. Conclusion: The ALGA-BC questionnaire with 29 items is a valid

  6. Development and testing of a hybrid system with a sub-kW open-cathode type PEM (proton exchange membrane) fuel cell stack

    International Nuclear Information System (INIS)

    Huang, Zhen-Ming; Su, Ay; Liu, Ying-Chieh

    2014-01-01

    In this study, the performance of a polymer electrolyte membrane fuel cell stack has been evaluated for a hybrid power system test platform. To simulate vehicle acceleration, the stack was operated under dynamic-loading, and to demonstrate the exchange of power flow between two power sources the hybrid power system was tested under three different modes. A unit cell was fabricated for high stack performance and the stack was constructed with 18 open-cathode type fuel cells. Air which acts as a coolant as well as an oxidant for electrochemical reactions is provided by a pair of fans. The capabilities of the stack for hybrid power system test platform were validated by successful dynamic-loading tests. The performance of the stack for various air fan voltage was evaluated and an optimal value was concluded. The conditions like inlet temperature of H 2 and the stack current were established for maximum power. It was also found that humidification of hydrogen at anode inlet degrades the stack performance and stability due to flooding. Evidence shows that for the higher overall performance, the fuel cell acts continuously on constant current output. The study contributes to the design of mobility hybrid system to get better performance and reliability. - Highlights: • An open-cathode type PEMFC (polymer electrolyte membrane fuel cell) stack (rated output 300 W) was fabricated. • The open-cathode configuration simplifies the design of a stack system. • Assess the feasibility of combining a fuel cell stack in a hybrid system. • The study contributes to the design of mobility hybrid system to get better performance and reliability

  7. Synthesis of Sine-on-Random vibration profiles for accelerated life tests based on fatigue damage spectrum equivalence

    Science.gov (United States)

    Angeli, Andrea; Cornelis, Bram; Troncossi, Marco

    2018-03-01

    In many real life environments, mechanical and electronic systems are subjected to vibrations that may induce dynamic loads and potentially lead to an early failure due to fatigue damage. Thus, qualification tests by means of shakers are advisable for the most critical components in order to verify their durability throughout the entire life cycle. Nowadays the trend is to tailor the qualification tests according to the specific application of the tested component, considering the measured field data as reference to set up the experimental campaign, for example through the so called "Mission Synthesis" methodology. One of the main issues is to define the excitation profiles for the tests, that must have, besides the (potentially scaled) frequency content, also the same damage potential of the field data despite being applied for a limited duration. With this target, the current procedures generally provide the test profile as a stationary random vibration specified by a Power Spectral Density (PSD). In certain applications this output may prove inadequate to represent the nature of the reference signal, and the procedure could result in an unrealistic qualification test. For instance when a rotating part is present in the system the component under analysis may be subjected to Sine-on-Random (SoR) vibrations, namely excitations composed of sinusoidal contributions superimposed to random vibrations. In this case, the synthesized test profile should preserve not only the induced fatigue damage but also the deterministic components of the environmental vibration. In this work, the potential advantages of a novel procedure to synthesize SoR profiles instead of PSDs for qualification tests are presented and supported by the results of an experimental campaign.

  8. Data Collection, Testing, and Analysis of Hybrid Electric Trucks and Buses Operating in California Fleets. Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Thornton, Matthew [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Duran, Adam [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Ragatz, Adam [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Cosgrove, Jon [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Sindler, Petr [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Russell, Robert [Univ. of California, Riverside, CA (United States); Johnson, Kent [Univ. of California, Riverside, CA (United States)

    2015-06-12

    The objective of this project was to evaluate and quantify the emission impacts of commercially available hybrid medium- and heavy-duty vehicles relative to their non-hybrid counterparts. This effort will allow the California Air Resources Board (CARB) and other agencies to more effectively encourage development and commercial deployment of the most efficient, lowest emitting hybrid technologies needed to meet air quality and climate goals.

  9. Development and experimental testing of a hybrid Stirling engine-adsorption chiller auxiliary power unit for heavy trucks

    International Nuclear Information System (INIS)

    Flannery, Barry; Lattin, Robert; Finckh, Oliver; Berresheim, Harald; Monaghan, Rory F.D.

    2017-01-01

    Highlights: • Free-piston Stirling engine for truck APU. • Waste heat driven adsorption chiller for cab air conditioning. • Reduced-order model comparing proposed system to existing technology. • Experimental test data from prototype test rig. - Abstract: This paper identifies the key technical requirements for a heavy truck auxiliary power unit (APU) and explores a potential alternative technology for use in a next-generation APU which could eliminate key problems related to emissions, noise and maintenance experienced today by conventional diesel engine-vapour compression APUs. The potential performance of a novel hybrid Stirling engine-adsorption chiller concept is investigated and benchmarked against the incumbent technology using a reduced-order model based on experimental data. Experimental results from a Stirling-adsorption system (SAS) prototype test rig are also presented which highlight system integration dynamics and overall performance. The adsorption chiller achieved an average COP of 0.42 ± 0.06 and 2.3 ± 0.1 kW_t of cooling capacity at the baseline test condition. The prototype SAS test rig demonstrates that there appear to be no major technology barriers remaining that would prevent adoption of the SAS concept in a next-generation APU. Such a system could offer a reduction of exhaust emissions, greenhouse gases (GHG), ozone-depleting substances, noise, low maintenance and the potential for fuel flexibility and higher reliability. Preliminary modelling results indicate that the proposed system could offer superior overall electrical and cooling efficiencies compared to incumbent APUs and demonstrate a payback period of 4.6 years.

  10. HPV test by Hybrid Capture II for the diagnosis of HR-HPV persistent infection.

    Science.gov (United States)

    Serour, Y; Bendahmane, M; Abbou Baker, F; Medles, M; Moueddene, B; Kraiba, R

    2017-11-01

    Persistent high-risk HPV (HR-HPV) infection is associated with a greater risk of cervical cancer. Statistical data on the prevalence of HR-HPV infections in the Algerian population is lacking. We conducted a prospective study of 300 women aged between 25 and 50 years, screened for cervical cancer from 2012 to 2015 in Sidi Bel Abbès, a western region of Algeria. We aimed to assess the reliability of the repeated use of the HC II test (three longitudinal HPV tests 9 months apart from each other) in diagnosing the persistence of HR-HPV infection. The prevalence of HR-HPV infection was 7.33% and infected women were aged 37.9±3years. For 90.9% of HR-HPV-positive patients, the infection persisted for a mean of 18.5months [95% CI: 16.9-22.1months]. Among these patients, 55.55% developed CIN1 and 11.11% developed CIN2. The sensitivity of the HC II test was 81.74% [95% CI: 71.3-89.6] and its positive predictive value associated with abnormal cervical biopsy was 27.49% [95% CI: 16.0-33.33]. Repeating the HC II test is a good predictor for identifying women at high risk of cervical cancer. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  11. 77 FR 11651 - Hybrid III 10-Year-Old Child Test Dummy

    Science.gov (United States)

    2012-02-27

    ... words, chin-to- chest contact often caused HIC to exceed the injury assessment reference value (HIC 36... bag tests).\\19\\ \\19\\ The computation of HIC applies a higher signal filter class (CFC 1000 vs. CFC 180... Dorel provided a picture of a torn bib assembly, without further discussion, in its response to the Part...

  12. ITER like lower hybrid passive active multi-junction antenna manufacturing and tests

    International Nuclear Information System (INIS)

    Guilhem, D.; Samaille, F.; Bertrand, B.; Lipa, M.; Achard, J.; Agarici, G.; Argouarch, A.; Armitano, A.; Bej, Z.; Berger-By, G.; Bouquey, F.; Brun, C.; Chantant, M.; Corbel, E.; Delmas, E.; Delpech, L.; Doceul, L.; Ekedahl, A.; Faisse, F.; Fejoz, P.; Goletto, C.; Goniche, M.; Hatchressian, J. C.; Hillairet, J.; Hoang, T.; Houry, M.; Joubert, P.; Lambert, R.; Lombard, G.; Madeleine, S.; Magne, R.; Marfisi, L.; Martinez, A.; Missirlian, M.; Mollard, P.; Poli, S.; Portafaix, C.; Preynas, M.; Prou, M.; Raulin, D.; Saille, A.; Soler, B.; Thouvenin, D.; Verger, J. M.; Volpe, D.; Vulliez, K.; Zago, B.

    2011-01-01

    A new concept of multijunction-type antenna has been developed, the Passive Active Multijunction, which improves the cooling of the waveguides and the damping of the neutron energy (for ITER) compared to Full Active Multijunction. Due to the complexity of the structures, prototypes of the mode converters and of the Passive-Active-Multijunction launcher were fabricated and tested, in order to validate the different manufacturing processes and the manufacturer's capability to face this challenging project. This paper describes the manufacturing process, the tests of the various prototypes and the construction of the final Passive-Active-Multijunction launcher, which entered into operation in October 2009. It has been commissioned and is fully operational on the Tore-Supra tokamak, since design objectives were reached in March 2010: 2.75 MW - 78 s, power density of 25 MW/m 2 in active waveguides, steady-state apparent surface temperatures ≤ 350 degrees C; 10 cm long distance coupling. (authors)

  13. Multiple group radiator and hybrid test heads, possibilities of combining the array technique

    International Nuclear Information System (INIS)

    Wuestenberg, H.

    1993-01-01

    This article is intended to show the important considerations, which led to the development of the multichannel group radiator technique. Trends in development and the advantages and disadvantages of the different possibilities are introduced, against the background of experience now available for these configurative variants of ultrasonic test heads. For this reason, a series of experiences and arguments is reported, from the point of view of the developer of the multi-channel group radiator technique. (orig./HP) [de

  14. Hybrid GPU-CPU adaptive precision ray-triangle intersection tests for robust high-performance GPU dosimetry computations

    International Nuclear Information System (INIS)

    Perrotte, Lancelot; Bodin, Bruno; Chodorge, Laurent

    2011-01-01

    Before an intervention on a nuclear site, it is essential to study different scenarios to identify the less dangerous one for the operator. Therefore, it is mandatory to dispose of an efficient dosimetry simulation code with accurate results. One classical method in radiation protection is the straight-line attenuation method with build-up factors. In the case of 3D industrial scenes composed of meshes, the computation cost resides in the fast computation of all of the intersections between the rays and the triangles of the scene. Efficient GPU algorithms have already been proposed, that enable dosimetry calculation for a huge scene (800000 rays, 800000 triangles) in a fraction of second. But these algorithms are not robust: because of the rounding caused by floating-point arithmetic, the numerical results of the ray-triangle intersection tests can differ from the expected mathematical results. In worst case scenario, this can lead to a computed dose rate dramatically inferior to the real dose rate to which the operator is exposed. In this paper, we present a hybrid GPU-CPU algorithm to manage adaptive precision floating-point arithmetic. This algorithm allows robust ray-triangle intersection tests, with very small loss of performance (less than 5 % overhead), and without any need for scene-dependent tuning. (author)

  15. Advantages of the in-situ LTP distortion profile test on high-heat-load mirrors and applications

    International Nuclear Information System (INIS)

    Qian, S.; Jark, W.; Sostero, G.; Gambitta, A.; Mazzolini, F.; Savoia, A.

    1996-01-01

    The first in-situ distortion profile measurement of a high heat load mirror by use of the penta-prism LTP is presented. A maximum height distortion of 0.47 micron in tangential direction over a length of 180 mm was measured for an internally water-cooled mirror of a undulator beam line at ELETTRA while exposed to a total emitted power of 600 W (undulator gap 30 mm and current 180 mA). The experiment has an accuracy and repeatability of 0.04 micron. The test schematic and the test equipment are presented. Two measuring methods to scan a penta-prism being installed either outside or inside the vacuum chamber are introduced. Advantages and some possible applications of adopting the penta-prism LTP to make the in-situ profile test are explained

  16. Background Pressure Profiles for Sonic Boom Vehicle Testing in the NASA Glenn 8- by 6-Foot Supersonic Wind Tunnel

    Science.gov (United States)

    Castner, Raymond; Shaw, Stephen; Adamson, Eric; Simerly, Stephanie

    2013-01-01

    In an effort to identify test facilities that offer sonic boom measurement capabilities, an exploratory test program was initiated using wind tunnels at NASA research centers. The subject of this report is the sonic boom pressure rail data collected in the Glenn Research Center 8- by 6-Foot Supersonic Wind Tunnel. The purpose is to summarize the lessons learned based on the test activity, specifically relating to collecting sonic boom data which has a large amount of spatial pressure variation. The wind tunnel background pressure profiles are presented as well as data which demonstrated how both wind tunnel Mach number and model support-strut position affected the wind tunnel background pressure profile. Techniques were developed to mitigate these effects and are presented.

  17. Beam Profile Measurement of 300 kV Ion Source Test Stand for 1 MV Electrostatic Accelerator

    International Nuclear Information System (INIS)

    Park, Sae-Hoon; Kim, Yu-Seok; Kim, Dae-Il; Kwon, Hyeok-Jung; Cho, Yong-Sub

    2015-01-01

    In this paper, RF ion source, test stand of the ion source and its test results are presented. Beam profile was measured at the downstream from the accelerating tube and at the beam dump by using BPM and wire scanner. The RF ion source of the test stand is verified by measuring the total beam current with a faraday cup in the chamber. The KOMAC (KOrea Multi-purpose Accelerator Complex) has been developing a 300 kV ion source test stand for a 1 MV electrostatic accelerator. An ion source and accelerating tube will be installed in a high pressure vessel. The ion source in a high pressure vessel requires high reliability. To confirm the stable operation of the ion source, a test stand was proposed and developed. The ion source will be tested at the test stand to verify its long-term operation conditions. The test stand consists of a 300 kV high voltage terminal, a battery for the ion source power, a 60 Hz inverter, a 200 MHz RF power, a 5 kV extraction power supply, a 300 kV accelerating tube, and a vacuum system. The beam profile monitor was installed at the downstream from the accelerating tube. Wire scanner and faraday-cup was installed at the end of the chamber

  18. Beam Profile Measurement of 300 kV Ion Source Test Stand for 1 MV Electrostatic Accelerator

    Energy Technology Data Exchange (ETDEWEB)

    Park, Sae-Hoon; Kim, Yu-Seok [Dongguk University, Gyeonju (Korea, Republic of); Kim, Dae-Il; Kwon, Hyeok-Jung; Cho, Yong-Sub [Korea Multipurpose Accelerator Complex, Gyeongju (Korea, Republic of)

    2015-10-15

    In this paper, RF ion source, test stand of the ion source and its test results are presented. Beam profile was measured at the downstream from the accelerating tube and at the beam dump by using BPM and wire scanner. The RF ion source of the test stand is verified by measuring the total beam current with a faraday cup in the chamber. The KOMAC (KOrea Multi-purpose Accelerator Complex) has been developing a 300 kV ion source test stand for a 1 MV electrostatic accelerator. An ion source and accelerating tube will be installed in a high pressure vessel. The ion source in a high pressure vessel requires high reliability. To confirm the stable operation of the ion source, a test stand was proposed and developed. The ion source will be tested at the test stand to verify its long-term operation conditions. The test stand consists of a 300 kV high voltage terminal, a battery for the ion source power, a 60 Hz inverter, a 200 MHz RF power, a 5 kV extraction power supply, a 300 kV accelerating tube, and a vacuum system. The beam profile monitor was installed at the downstream from the accelerating tube. Wire scanner and faraday-cup was installed at the end of the chamber.

  19. Automation of ALK gene rearrangement testing with fluorescence in situ hybridization (FISH): a feasibility study.

    Science.gov (United States)

    Zwaenepoel, Karen; Merkle, Dennis; Cabillic, Florian; Berg, Erica; Belaud-Rotureau, Marc-Antoine; Grazioli, Vittorio; Herelle, Olga; Hummel, Michael; Le Calve, Michele; Lenze, Dido; Mende, Stefanie; Pauwels, Patrick; Quilichini, Benoit; Repetti, Elena

    2015-02-01

    In the past several years we have observed a significant increase in our understanding of molecular mechanisms that drive lung cancer. Specifically in the non-small cell lung cancer sub-types, ALK gene rearrangements represent a sub-group of tumors that are targetable by the tyrosine kinase inhibitor Crizotinib, resulting in significant reductions in tumor burden. Phase II and III clinical trials were performed using an ALK break-apart FISH probe kit, making FISH the gold standard for identifying ALK rearrangements in patients. FISH is often considered a labor and cost intensive molecular technique, and in this study we aimed to demonstrate feasibility for automation of ALK FISH testing, to improve laboratory workflow and ease of testing. This involved automation of the pre-treatment steps of the ALK assay using various protocols on the VP 2000 instrument, and facilitating automated scanning of the fluorescent FISH specimens for simplified enumeration on various backend scanning and analysis systems. The results indicated that ALK FISH can be automated. Significantly, both the Ikoniscope and BioView system of automated FISH scanning and analysis systems provided a robust analysis algorithm to define ALK rearrangements. In addition, the BioView system facilitated consultation of difficult cases via the internet. Copyright © 2015 Elsevier Inc. All rights reserved.

  20. A Prototype Regional GSI-based EnKF-Variational Hybrid Data Assimilation System for the Rapid Refresh Forecasting System: Dual-Resolution Implementation and Testing Results

    Science.gov (United States)

    Pan, Yujie; Xue, Ming; Zhu, Kefeng; Wang, Mingjun

    2018-05-01

    A dual-resolution (DR) version of a regional ensemble Kalman filter (EnKF)-3D ensemble variational (3DEnVar) coupled hybrid data assimilation system is implemented as a prototype for the operational Rapid Refresh forecasting system. The DR 3DEnVar system combines a high-resolution (HR) deterministic background forecast with lower-resolution (LR) EnKF ensemble perturbations used for flow-dependent background error covariance to produce a HR analysis. The computational cost is substantially reduced by running the ensemble forecasts and EnKF analyses at LR. The DR 3DEnVar system is tested with 3-h cycles over a 9-day period using a 40/˜13-km grid spacing combination. The HR forecasts from the DR hybrid analyses are compared with forecasts launched from HR Gridpoint Statistical Interpolation (GSI) 3D variational (3DVar) analyses, and single LR hybrid analyses interpolated to the HR grid. With the DR 3DEnVar system, a 90% weight for the ensemble covariance yields the lowest forecast errors and the DR hybrid system clearly outperforms the HR GSI 3DVar. Humidity and wind forecasts are also better than those launched from interpolated LR hybrid analyses, but the temperature forecasts are slightly worse. The humidity forecasts are improved most. For precipitation forecasts, the DR 3DEnVar always outperforms HR GSI 3DVar. It also outperforms the LR 3DEnVar, except for the initial forecast period and lower thresholds.

  1. Test beam analysis of ultra-thin hybrid pixel detector assemblies with Timepix readout ASICs

    CERN Document Server

    Alipour Tehrani, Niloufar; Dannheim, Dominik; Firu, Elena; Kulis, Szymon; Redford, Sophie; Sicking, Eva

    2016-01-01

    The requirements for the vertex detector at the proposed Compact Linear Collider imply a very small material budget: less than 0.2% of a radiation length per detection layer including services and mechanical supports. We present here a study using Timepix readout ASICs hybridised to pixel sensors of 50 − 500 μm thickness, including assemblies with 100 μm thick sensors bonded to thinned 100μm thick ASICs. Sensors from three producers (Advacam, Micron Semiconductor Ltd, Canberra) with different edge termination technologies (active edge, slim edge) were bonded to Timepix ASICs. These devices were characterised with the EUDET telescope at the DESY II test beam using 5.6 GeV electrons. Their performance for the detection and tracking of minimum ionising particles was evaluated in terms of charge sharing, detection efficiency, single-point resolution and energy deposition.

  2. Using pathology-specific laboratory profiles in Clinical Pathology to reduce inappropriate test requesting: two completed audit cycles

    Science.gov (United States)

    2012-01-01

    Background Systematic reviews have shown that, although well prepared, the Consensus Guidelines have failed to change clinical practice. In the healthcare district of Castelnovo né Monti (Reggio Emilia, Italy), it became necessary for the GPs and Clinical Pathologists to work together to jointly define laboratory profiles. Methods Observational study with two cycles of retrospective audit on test request forms, in a primary care setting. Objectives of the study were to develop pathology-specific laboratory profiles and to increase the number of provisional diagnoses on laboratory test request forms. A Multiprofessional Multidisciplinary Inter-hospital Work Team developed pathology-specific laboratory profiles for more effective test requesting. After 8 training sessions that used a combined strategy with multifaceted interventions, the 23 General Practitioners (GPs) in the trial district (Castelnovo nè Monti) tested the profiles; the 21 GPs in the Puianello district were the control group; all GPs in both districts participated in the trial. All laboratory tests for both healthcare districts are performed at the Laboratory located in the trial district. A baseline and a 1-year audit were performed in both districts on the GPs’ request forms. Results Seven pathology-specific laboratory profiles for outpatients were developed. In the year after the first audit cycle: 1) the number of tests requested in the trial district was distinctly lower than that in the previous year, with a decrease of about 5% (p < 0.001); 2) the provisional diagnosis on the request forms was 52.8% in the trial district and 42% in the control district (P < 0.001); 3) the decrease of the number of tests on each request form was much more marked in the trial district (8.73 vs. 10.77; p < 0.001). Conclusions The first audit cycle showed a significant decrease in the number of tests ordered only in the trial district. The combined strategy used in this study improved the

  3. Hybrid Propulsion Demonstration Program 250K Hybrid Motor

    Science.gov (United States)

    Story, George; Zoladz, Tom; Arves, Joe; Kearney, Darren; Abel, Terry; Park, O.

    2003-01-01

    The Hybrid Propulsion Demonstration Program (HPDP) program was formed to mature hybrid propulsion technology to a readiness level sufficient to enable commercialization for various space launch applications. The goal of the HPDP was to develop and test a 250,000 pound vacuum thrust hybrid booster in order to demonstrate hybrid propulsion technology and enable manufacturing of large hybrid boosters for current and future space launch vehicles. The HPDP has successfully conducted four tests of the 250,000 pound thrust hybrid rocket motor at NASA's Stennis Space Center. This paper documents the test series.

  4. Energy Management of a Hybrid AC–DC Micro-Grid Based on a Battery Testing System

    Directory of Open Access Journals (Sweden)

    Bo Long

    2015-02-01

    Full Text Available Energy Recovery Battery Testing Systems (ERBTS plays an important role in battery manufacture. The conventional ERBTS configuration contains a fundamental transformer, and a bidirectional Direct Current (DC–DC and Alternating Current (AC–DC converter. All ERBTS are connected in parallel, thus constituting a special and complicated AC micro-grid system. Aiming at addressing their low energy recovery efficiency, complex grid-connected control algorithm issues for islanded detection, and complicated power circuit topology issues, a hierarchical DC-link voltage hybrid AC–DC micro-grid that contains composite energy storing devices is proposed. Moreover, an energy management optimal scheme for the proposed scheme is put forward. The system configuration of the proposed scheme is described in detail. Compared to the conventional scheme, the proposed scheme has the merits of simplified power circuit topology, no need for phase synchronous control, and much higher energy recovery efficiency and reliability. The validity and effectiveness of the proposed technique is verified through numerous experimental results.

  5. JPL's electric and hybrid vehicles project: Project activities and preliminary test results. [power conditioning and battery charge efficiency

    Science.gov (United States)

    Barber, T. A.

    1980-01-01

    Efforts to achieve a 100 mile urban range, to reduce petroleum usage 40% to 70%, and to commercialize battery technology are discussed with emphasis on an all plastic body, four passenger car that is flywheel assisted and battery powered, and on an all metal body, four passenger car with front wheel drive and front motor. For the near term case, a parallel hybrid in which the electric motor and the internal combustion engine may directly power the drive wheels, is preferred to a series design. A five passenger car in which the electric motor and the gasoline engine both feed into the same transmission is discussed. Upgraded demonstration vehicles were tested using advanced lead acid, nickel zinc, nickel iron, and zinc chloride batteries to determine maximum acceleration, constant speed, and battery behavior. The near term batteries demonstrated significant improvement relative to current lead acid batteries. The increase in range was due to improved energy density, and ampere hour capacity, with relatively 1 small weight and volume differences.

  6. The Influences of Arm Resist Motion on a CAR Crash Test Using Hybrid III Dummy with Human-Like Arm

    Science.gov (United States)

    Kim, Yongchul; Youm, Youngil; Bae, Hanil; Choi, Hyeonki

    Safety of the occupant during the crash is very essential design element. Many researches have been investigated in reducing the fatal injury of occupant. They are focusing on the development of a dummy in order to obtain the real human-like motion. However, they have not considered the arm resist motion during the car accident. In this study, we would like to suggest the importance of the reactive force of the arm in a car crash. The influences of reactive force acting on the human upper extremity were investigated using the impedance experimental method with lumped mass model of hand system and a Hybrid III dummy with human-like arm. Impedance parameters (e.g. inertia, spring constant and damping coefficient) of the elbow joint in maximum activation level were measured by free oscillation test using single axis robot. The results showed that without seat belt, the reactive force of human arm reduced the head, chest, and femur injury, and the flexion moment of the neck is higher than that of the conventional dummy.

  7. Performance of ProEx C and PreTect HPV-Proofer E6/E7 mRNA tests in comparison with the hybrid capture 2 HPV DNA test for triaging ASCUS and LSIL cytology.

    Science.gov (United States)

    Alaghehbandan, Reza; Fontaine, Daniel; Bentley, James; Escott, Nicholas; Ghatage, Prafull; Lear, Adrian; Coutlee, Francois; Ratnam, Samuel

    2013-09-01

    The clinical usefulness of the ProEx C (Becton Dickinson) and PreTect HPV-Proofer E6/E7 mRNA tests (Proofer; Norchip) for the triage of ASCUS and LSIL cytology was determined in comparison with the Hybrid Capture 2 HPV DNA test (HC2; Qiagen). The study population consisted of women with a history of abnormal cytology referred to colposcopy. Histology-confirmed CIN 2+ served as the disease endpoint. The study was based on 1,360 women (mean age 30.7 years), of whom 380 had CIN 2+. Among 315 with ASCUS (CIN 2+, n = 67), the sensitivities of ProEx C, Proofer, and HC2 to detect CIN 2+ were, 71.6, 71.6, and 95.5%, respectively, with a corresponding specificity of 74.6, 74.2, and 35.1%. Among 363 with LSIL (CIN 2+, n = 108), the sensitivities of ProEx C, Proofer, and HC2 were, 67.6, 74.1, and 96.3%, respectively, with a corresponding specificity of 60, 68.2, and 18.4%. Among 225 HC2-positive ASCUS (CIN 2+, n = 64), 105 tested positive by ProEx C, reducing colposcopy referral by 53.3% and detecting 71.9% of CIN 2+; Proofer was positive in 112/225, reducing colposcopy referral by 50.2% and detecting 75.0% of CIN 2+. Among 312 HC2-positive LSIL (CIN 2+, n = 104), 160 tested positive by ProEx C, reducing coloposcopy referral by 48.7% and detecting 66.3% of CIN 2+; Proofer was positive in 159/312, reducing colposcopy referral by 49.0% and detecting 75.0% of CIN 2+. In conclusion, both ProEx C and Proofer have a similar performance profile with a significantly higher specificity but lower sensitivity than HC2 for the detection of CIN 2+. Consequently, although they can reduce colposcopy referral, they will miss a proportion of CIN 2+ cases. This is a major limitation and should be taken into account if these tests are considered for ASCUS or LSIL triage. Copyright © 2012 Wiley Periodicals, Inc., a Wiley company.

  8. PIGE - Resonance profiling applied to a clinical test of flouride varnishes

    Science.gov (United States)

    Zschau, H. E.; Plier, F.; Otto, G.; Wyrwich, C.; Treide, A.

    1992-03-01

    A clinical in-vivo experiment had been carried out to compare two caries preventing fluorine varnishes. The fluorine depth profiles in the near surface region of tooth enamel were measured using the 935 keV resonance of the nuclear reaction 19F( p, p' γ) 19F. The results can be understood by studying the flourine anamnese of the patients.

  9. Publishing in Library Science Journals: A Test of the Olsgaard Profile.

    Science.gov (United States)

    Adamson, Martha C.; Zamora, Gloria J.

    1981-01-01

    Replicating to a high degree the results of the Olsgaard profile of authorship characteristics in academic library journals, this study analyzed five journals of interest to special librarians to determine gender, geographic location, and occupation of author contributors. Results indicate that women are consistently underrepresented in the…

  10. Metabolic profiling of the response to an oral glucose tolerance test detects subtle metabolic changes.

    NARCIS (Netherlands)

    Wopereis, S.; Rubingh, C.M. de; Erk, M.J. van; Verheij, E.R.; Vliet, T. van; Cnubben, N.H.; Smilde, A.K.; Greef, J. van der; Ommen, B. van; Hendriks, H.F.

    2009-01-01

    BACKGROUND: The prevalence of overweight is increasing globally and has become a serious health problem. Low-grade chronic inflammation in overweight subjects is thought to play an important role in disease development. Novel tools to understand these processes are needed. Metabolic profiling is one

  11. CLASH-VLT: testing the nature of gravity with galaxy cluster mass profiles

    Energy Technology Data Exchange (ETDEWEB)

    Pizzuti, L.; Sartoris, B.; Borgani, S.; Girardi, M. [Dipartimento di Fisica, Sezione di Astronomia, Università di Trieste, Via Tiepolo 11, I-34143 Trieste (Italy); Amendola, L. [Institut für Theoretische Physik, Universität Heidelberg, Philosophenweg 16, D-69120 Heidelberg (Germany); Umetsu, K. [5 Institute of Astronomy and Astrophysics, Academia Sinica, P.O. Box 23-141, Taipei 10617, Taiwan (China); Biviano, A.; Balestra, I.; Nonino, M. [INAF—Osservatorio Astronomico di Trieste, Via Tiepolo 11, I-34143 Trieste (Italy); Rosati, P. [University Observatory Munich, Scheinerstrasse 1, D-81679 Mu\\' nchen (Germany); Caminha, G.B. [Dipartimento di Fisica e Scienze della Terra, Università di Ferrara, Via Saragat 1, I-44122 Ferrara (Italy); Frye, B. [Steward Observatory/Department of Astronomy, University of Arizona, 933 N Cherry Ave, Tucson, AZ 85721 (United States); Koekemoer, A. [Space Telescope Science Institute, 3700 San Martin Drive, Baltimore, MD 21218 (United States); Grillo, C. [Dark Cosmology Centre, Niels Bohr Institute, University of Copenhagen, Juliane Maries Vej 30, DK-2100 Copenhagen (Denmark); Lombardi, M. [Dipartimento di Fisica, Università degli Studi di Milano, via Celoria 16, I-20133 Milan (Italy); Mercurio, A., E-mail: pizzuti@oats.inaf.it, E-mail: barbara.sartoris@gmail.com, E-mail: borgani@oats.inaf.it, E-mail: l.amendola@thphys.uniheidelberg.de [Osservatorio Astronomico di Capodimonte, Via Moiariello 16, I-80131 Napoli (Italy)

    2016-04-01

    We use high-precision kinematic and lensing measurements of the total mass profile of the dynamically relaxed galaxy cluster MACS J1206.2-0847 at z=0.44 to estimate the value of the ratio η=Ψ/Φ between the two scalar potentials in the linear perturbed Friedmann-Lemaitre-Robertson-Walker metric. An accurate measurement of this ratio, called anisotropic stress, could show possible, interesting deviations from the predictions of the theory of General Relativity, according to which Ψ should be equal to Φ. Complementary kinematic and lensing mass profiles were derived from exhaustive analyses using the data from the Cluster Lensing And Supernova survey with Hubble (CLASH) and the spectroscopic follow-up with the Very Large Telescope (CLASH-VLT). Whereas the kinematic mass profile tracks only the time-time part of the perturbed metric (i.e. only Φ), the lensing mass profile reflects the contribution of both time-time and space-space components (i.e. the sum Φ+Ψ). We thus express η as a function of the mass profiles and perform our analysis over the radial range 0.5 Mpc≤ r≤ r{sub 200}=1.96 Mpc. Using a spherical Navarro-Frenk-White mass profile, which well fits the data, we obtain η(r{sub 200})=1.01 {sub −0.28}{sup +0.31} at the 68% C.L. We discuss the effect of assuming different functional forms for mass profiles and of the orbit anisotropy in the kinematic reconstruction. Interpreting this result within the well-studied f(R) modified gravity model, the constraint on η translates into an upper bound to the interaction length (inverse of the scalaron mass) smaller than 2 Mpc. This tight constraint on the f(R) interaction range is however substantially relaxed when systematic uncertainties in the analysis are considered. Our analysis highlights the potential of this method to detect deviations from general relativity, while calling for the need of further high-quality data on the total mass distribution of clusters and improved control on systematic

  12. Rational Design and Multibiological Profiling of Novel Donepezil-Trolox Hybrids against Alzheimer's Disease, with Cholinergic, Antioxidant, Neuroprotective, and Cognition Enhancing Properties.

    Science.gov (United States)

    Cai, Pei; Fang, Si-Qiang; Yang, Xue-Lian; Wu, Jia-Jia; Liu, Qiao-Hong; Hong, Hao; Wang, Xiao-Bing; Kong, Ling-Yi

    2017-11-15

    A novel series of donepezil-trolox hybrids were designed, synthesized, and evaluated as multifunctional ligands against Alzheimer's disease (AD). Biological assays showed that these derivatives possessed moderate to good inhibitory activities against acetylcholinesterase (AChE) and monoamine oxidase B (MAO-B) as well as remarkable antioxidant effects. The optimal compound 6d exhibited balanced functions with good inhibition against hAChE (IC 50 = 0.54 μM) and hMAO-B (IC 50 = 4.3 μM), significant antioxidant activity (41.33 μM IC 50 by DPPH method, 1.72 and 1.79 trolox equivalent by ABTS and ORAC methods), excellent copper chelation, and Aβ 1-42 aggregation inhibition effect. Furthermore, cellular tests indicated that 6d has very low toxicity and is capable of combating oxidative toxin (H 2 O 2 , rotenone, and oligomycin-A) induced neurotoxicity. Most importantly, oral administration of 6d demonstrated notable improvements on cognition and spatial memory against scopolamine-induced acute memory deficit as well as d-galactose (d-gal) and AlCl 3 induced chronic oxidative stress in a mouse model without acute toxicity and hepatotoxicity. In summary, both in vitro and in vivo results suggested that 6d is a valuable candidate for the development of a safe and effective anti-Alzheimer's drug.

  13. Phenolic content and antioxidant capacity of hybrid variety cocoa beans.

    Science.gov (United States)

    Jonfia-Essien, W A; West, G; Alderson, P G; Tucker, G

    2008-06-01

    Cocoa (Theobroma cacao L.) is a major, economically important, international crop and has been associated with several nutritional benefits including high antioxidant capacity. New cocoa hybrids have been developed in Ghana that exhibit resistance to pest damage during storage. The aim of this work was to assess the phenolic content and antioxidant capacity of these new hybrids in comparison to more traditional cocoa varieties. Total extractable phenolics were similar in all the four hybrids tested ranging from 69.9 to 81.6FAEg(-1). These levels were very similar to that extracted from traditional beans (73.8±2.5FAEg(-1)). The "phenolic profile" was determined by HPLC. A total of 25 peaks was observed but there were only minor differences in this profile between traditional and hybrid bean extracts. Antioxidant capacity was determined using the FRAP assay and traditional beans were found to possess 12.4μmolTEg(-1). In comparison the hybrid beans had antioxidant capacities ranging from 21.6 to 45.5μmolTEg(-1), and these were significantly higher than in the traditional beans for three out of the four hybrids. Since the phenolic and antioxidant levels and in these hybrid varieties were either similar to, or higher than, that obtained from traditional beans, the introduction of these new varieties would be unlikely to impact detrimentally on these nutritional components of the beans. Copyright © 2007 Elsevier Ltd. All rights reserved.

  14. Hybrid optical navigation by crater detection for lunar pin-point landing: trajectories from helicopter flight tests

    Science.gov (United States)

    Trigo, Guilherme F.; Maass, Bolko; Krüger, Hans; Theil, Stephan

    2018-01-01

    Accurate autonomous navigation capabilities are essential for future lunar robotic landing missions with a pin-point landing requirement, since in the absence of direct line of sight to ground control during critical approach and landing phases, or when facing long signal delays the herein before mentioned capability is needed to establish a guidance solution to reach the landing site reliably. This paper focuses on the processing and evaluation of data collected from flight tests that consisted of scaled descent scenarios where the unmanned helicopter of approximately 85 kg approached a landing site from altitudes of 50 m down to 1 m for a downrange distance of 200 m. Printed crater targets were distributed along the ground track and their detection provided earth-fixed measurements. The Crater Navigation (CNav) algorithm used to detect and match the crater targets is an unmodified method used for real lunar imagery. We analyze the absolute position and attitude solutions of CNav obtained and recorded during these flight tests, and investigate the attainable quality of vehicle pose estimation using both CNav and measurements from a tactical-grade inertial measurement unit. The navigation filter proposed for this end corrects and calibrates the high-rate inertial propagation with the less frequent crater navigation fixes through a closed-loop, loosely coupled hybrid setup. Finally, the attainable accuracy of the fused solution is evaluated by comparison with the on-board ground-truth solution of a dual-antenna high-grade GNSS receiver. It is shown that the CNav is an enabler for building autonomous navigation systems with high quality and suitability for exploration mission scenarios.

  15. Test and development of a solar-hybrid vehicle prototype and turbo-compressor model for automotive engines

    OpenAIRE

    Naddeo, Massimo

    2016-01-01

    2014 - 2015 In last decade, Hybrid Electric Vehicles (HEV) have emerged as real alternatives to engine-driven vehicles, in order to reduce fuel consumption and emissions.... [edited by author] XIV n.s.

  16. Genomic profiling using array comparative genomic hybridization define distinct subtypes of diffuse large b-cell lymphoma: a review of the literature

    Directory of Open Access Journals (Sweden)

    Tirado Carlos A

    2012-09-01

    Full Text Available Abstract Diffuse large B-cell lymphoma (DLBCL is the most common type of non-Hodgkin Lymphoma comprising of greater than 30% of adult non-Hodgkin Lymphomas. DLBCL represents a diverse set of lymphomas, defined as diffuse proliferation of large B lymphoid cells. Numerous cytogenetic studies including karyotypes and fluorescent in situ hybridization (FISH, as well as morphological, biological, clinical, microarray and sequencing technologies have attempted to categorize DLBCL into morphological variants, molecular and immunophenotypic subgroups, as well as distinct disease entities. Despite such efforts, most lymphoma remains undistinguishable and falls into DLBCL, not otherwise specified (DLBCL-NOS. The advent of microarray-based studies (chromosome, RNA, gene expression, etc has provided a plethora of high-resolution data that could potentially facilitate the finer classification of DLBCL. This review covers the microarray data currently published for DLBCL. We will focus on these types of data; 1 array based CGH; 2 classical CGH; and 3 gene expression profiling studies. The aims of this review were three-fold: (1 to catalog chromosome loci that are present in at least 20% or more of distinct DLBCL subtypes; a detailed list of gains and losses for different subtypes was generated in a table form to illustrate specific chromosome loci affected in selected subtypes; (2 to determine common and distinct copy number alterations among the different subtypes and based on this information, characteristic and similar chromosome loci for the different subtypes were depicted in two separate chromosome ideograms; and, (3 to list re-classified subtypes and those that remained indistinguishable after review of the microarray data. To the best of our knowledge, this is the first effort to compile and review available literatures on microarray analysis data and their practical utility in classifying DLBCL subtypes. Although conventional cytogenetic methods such

  17. Signal process and profile reconstruction of stress corrosion crack by eddy current test

    International Nuclear Information System (INIS)

    Zhang Siquan; Chen Tiequn; Liu Guixiong

    2008-01-01

    The reconstruction of crack profiles is very important in the NDE (nondestructive evaluation) of critical structures, such as pressure vessel and tubes in heat exchangers. First a wavelet transform signal processing technique is used to reduce noise and other non-defect signals from the signals of crack, and then based on an artificial neural network method, the crack profiles are reconstructed. Although the results reveal that this method is with many advantages such as a short CPU time and precision for reconstruction,it does have some drawbacks, for example, the database generation and network training is a much time consuming work. Moreover, this approach does not expressly reconstruct the distribution of conductivity inside a crack, so the reliability of a reconstructed crack shape is unknown. But in practical application, if we do not consider the multiple cracks, this method can be used to reconstruct the natural crack. (authors)

  18. Cognitive profile in elementary algebra: the PÉPITE test interface

    OpenAIRE

    Jean , Stéphanie; Delozanne , Elisabeth; Jacoboni , Pierre; Grugeon , Brigitte

    1998-01-01

    International audience; The work presented here is part of a multidisciplinary project, called the PÉPITE project. Its aim is to set up a system to diagnose student profiles starting from a multidimensional analysis grid to evaluate their competences in elementary algebra. This paper deals with the design, the making and the evaluation of an interface in Computer Based Learning Environments. In it, we present the method adopted to set up software which proposes tasks to the students and colle...

  19. Resemblance profiles as clustering decision criteria: Estimating statistical power, error, and correspondence for a hypothesis test for multivariate structure.

    Science.gov (United States)

    Kilborn, Joshua P; Jones, David L; Peebles, Ernst B; Naar, David F

    2017-04-01

    Clustering data continues to be a highly active area of data analysis, and resemblance profiles are being incorporated into ecological methodologies as a hypothesis testing-based approach to clustering multivariate data. However, these new clustering techniques have not been rigorously tested to determine the performance variability based on the algorithm's assumptions or any underlying data structures. Here, we use simulation studies to estimate the statistical error rates for the hypothesis test for multivariate structure based on dissimilarity profiles (DISPROF). We concurrently tested a widely used algorithm that employs the unweighted pair group method with arithmetic mean (UPGMA) to estimate the proficiency of clustering with DISPROF as a decision criterion. We simulated unstructured multivariate data from different probability distributions with increasing numbers of objects and descriptors, and grouped data with increasing overlap, overdispersion for ecological data, and correlation among descriptors within groups. Using simulated data, we measured the resolution and correspondence of clustering solutions achieved by DISPROF with UPGMA against the reference grouping partitions used to simulate the structured test datasets. Our results highlight the dynamic interactions between dataset dimensionality, group overlap, and the properties of the descriptors within a group (i.e., overdispersion or correlation structure) that are relevant to resemblance profiles as a clustering criterion for multivariate data. These methods are particularly useful for multivariate ecological datasets that benefit from distance-based statistical analyses. We propose guidelines for using DISPROF as a clustering decision tool that will help future users avoid potential pitfalls during the application of methods and the interpretation of results.

  20. Comparison of aggregate stability within six soil profiles under conventional tillage using various laboratory tests

    Czech Academy of Sciences Publication Activity Database

    Kodešová, R.; Rohošková, M.; Žigová, Anna

    2009-01-01

    Roč. 64, č. 3 (2009), s. 550-554 ISSN 0006-3088 R&D Projects: GA ČR GA526/08/0434 Institutional research plan: CEZ:AV0Z30130516 Keywords : fast wetting test * slow wetting test * shaking after pre-wetting test * wet sewing Subject RIV: DF - Soil Science Impact factor: 0.617, year: 2009

  1. Design, Analysis, Hybrid Testing and Orientation Control of a Floating Platform with Counter-Rotating Vertical-Axis Wind Turbines

    Science.gov (United States)

    Kanner, Samuel Adam Chinman

    The design and operation of two counter-rotating vertical-axis wind turbines on a floating, semi-submersible platform is studied. The technology, called the Multiple Integrated and Synchronized Turbines (MIST) platform has the potential to reduce the cost of offshore wind energy per unit of installed capacity. Attached to the platform are closely-spaced, counter-rotating turbines, which can achieve a higher power density per planform area because of synergistic interaction effects. The purpose of the research is to control the orientation of the platform and rotational speeds of the turbines by modifying the energy absorbed by each of the generators of the turbines. To analyze the various aspects of the platform and wind turbines, the analysis is drawn from the fields of hydrodynamics, electromagnetics, aerodynamics and control theory. To study the hydrodynamics of the floating platform in incident monochromatic waves, potential theory is utilized, taking into account the slow-drift yaw motion of the platform. Steady, second-order moments that are spatially dependent (i.e., dependent on the platform's yaw orientation relative to the incident waves) are given special attention since there are no natural restoring yaw moment. The aerodynamics of the counter-rotating turbines are studied in collaboration with researchers at the UC Berkeley Mathematics Department using a high-order, implicit, large-eddy simulation. An element flipping technique is utilized to extend the method to a domain with counter-rotating turbines and the effects from the closely-spaced turbines is compared with existing experimental data. Hybrid testing techniques on a model platform are utilized to prove the controllability of the platform in lieu of a wind-wave tank. A 1:82 model-scale floating platform is fabricated and tested at the UC Berkeley Physical-Model Testing Facility. The vertical-axis wind turbines are simulated by spinning, controllable actuators that can be updated in real-time of

  2. Performance of a high-work low aspect ration turbine tested with a realistic inlet radial temperature profile

    Science.gov (United States)

    Stabe, R. G.; Whitney, W. J.; Moffitt, T. P.

    1984-01-01

    Experimental results are presented for a 0.767 scale model of the first stage of a two-stage turbine designed for a high by-pass ratio engine. The turbine was tested with both uniform inlet conditions and with an inlet radial temperature profile simulating engine conditions. The inlet temperature profile was essentially mixed-out in the rotor. There was also substantial underturning of the exit flow at the mean diameter. Both of these effects were attributed to strong secondary flows in the rotor blading. There were no significant differences in the stage performance with either inlet condition when differences in tip clearance were considered. Performance was very close to design intent in both cases.

  3. Performance of a high-work low aspect ratio turbine tested with a realistic inlet radial temperature profile

    Science.gov (United States)

    Stabe, R. G.; Whitney, W. J.; Moffitt, T. P.

    1984-01-01

    Experimental results are presented for a 0.767 scale model of the first stage of a two-stage turbine designed for a high by-pass ratio engine. The turbine was tested with both uniform inlet conditions and with an inlet radial temperature profile simulating engine conditions. The inlet temperature profile was essentially mixed-out in the rotor. There was also substantial underturning of the exit flow at the mean diameter. Both of these effects were attributed to strong secondary flows in the rotor blading. There were no significant differences in the stage performance with either inlet condition when differences in tip clearance were considered. Performance was very close to design intent in both cases. Previously announced in STAR as N84-24589

  4. Modeling and Experimental Tests of a Mechatronic Device to Measure Road Profiles Considering Impact Dynamics

    DEFF Research Database (Denmark)

    Souza, A.; Santos, Ilmar

    2002-01-01

    dynamics is led with help of a set of non-linear equations of motion obtained using Newton-Euler-Jourdain´s Method. Such a set of equation is numerically solved and the theoretical results are compared with experimental carried out with a laboratory prototype. Comparisons show that the theoretical model...... predicts well the mechanism movements. However it was also experimentally observed that the contact between the wheels and the road profile is not permanent. To analyze the non-contact between the wheels and the road, the Newton-Euler´s Method is used to calculate forces and moments of reactions between...

  5. Genetic, morphological, and spectral characterization of relictual Niobrara River hybrid aspens (Populus × smithii).

    Science.gov (United States)

    Deacon, Nicholas John; Grossman, Jake Joseph; Schweiger, Anna Katharina; Armour, Isabella; Cavender-Bares, Jeannine

    2017-12-01

    Aspen groves along the Niobrara River in Nebraska have long been a biogeographic curiosity due to morphological differences from nearby remnant Populus tremuloides populations. Pleistocene hybridization between P. tremuloides and P. grandidentata has been proposed, but the nearest P. grandidentata populations are currently several hundred kilometers east. We tested the hybrid-origin hypothesis using genetic data and characterized putative hybrids phenotypically. We compared nuclear microsatellite loci and chloroplast sequences of Niobrara River aspens to their putative parental species. Parental species and putative hybrids were also grown in a common garden for phenotypic comparison. On the common garden plants, we measured leaf morphological traits and leaf-level spectral reflectance profiles, from which chemical traits were derived. The genetic composition of the three unique Niobrara aspen genotypes is consistent with the hybridization hypothesis and with maternal chloroplast inheritance from P. grandidentata . Leaf margin dentition and abaxial pubescence differentiated taxa, with the hybrids showing intermediate values. Spectral profiles allowed statistical separation of taxa in short-wave infrared wavelengths, with hybrids showing intermediate values, indicating that traits associated with internal structure of leaves and water absorption may vary among taxa. However, reflectance values in the visible region did not differentiate taxa, indicating that traits related to pigments are not differentiated. Both genetic and phenotypic results support the hypothesis of a hybrid origin for these genetically unique aspens. However, low genetic diversity and ongoing ecological and climatic threats to the hybrid taxon present a challenge for conservation of these relictual boreal communities. © 2017 Botanical Society of America.

  6. Kaner biodiesel production through hybrid reactor and its performance testing on a CI engine at different compression ratios

    Directory of Open Access Journals (Sweden)

    Ashok Kumar Yadav

    2017-06-01

    Full Text Available The present study deals with development of a hybrid reactor for biodiesel production based on the combined hydrodynamic cavitation and mechanical stirring processes. Biodiesel were produced using Kaner Seed Oil (KSO. The experimental results show that hybrid reactor produces 95% biodiesel yield within 45 min for 0.75% of catalyst and 6:1 M ratio which is significantly higher as compared to mechanical stirring or hydrodynamic cavitation alone. Thus biodiesel production process in hybrid reactor is cheap (high yield, efficient (time saving and environmentally friendly (lower% of catalyst. Performance study on engine shows that an increase in compression ratios (from 16 to 18 improves the engine performance using biodiesel blends as compared to petroleum diesel.

  7. Using Line Profiles to Test the Fraternity of Type Ia Supernovae at High and Low Redshifts

    Science.gov (United States)

    Blondin, Stéphane; Dessart, Luc; Leibundgut, Bruno; Branch, David; Höflich, Peter; Tonry, John L.; Matheson, Thomas; Foley, Ryan J.; Chornock, Ryan; Filippenko, Alexei V.; Sollerman, Jesper; Spyromilio, Jason; Kirshner, Robert P.; Wood-Vasey, W. Michael; Clocchiatti, Alejandro; Aguilera, Claudio; Barris, Brian; Becker, Andrew C.; Challis, Peter; Covarrubias, Ricardo; Davis, Tamara M.; Garnavich, Peter; Hicken, Malcolm; Jha, Saurabh; Krisciunas, Kevin; Li, Weidong; Miceli, Anthony; Miknaitis, Gajus; Pignata, Giuliano; Prieto, Jose Luis; Rest, Armin; Riess, Adam G.; Salvo, Maria Elena; Schmidt, Brian P.; Smith, R. Chris; Stubbs, Christopher W.; Suntzeff, Nicholas B.

    2006-03-01

    Using archival data of low-redshift (z1.7] SNe Ia, which are also subluminous. In addition, we give the first direct evidence in two high-z SN Ia spectra of a double-absorption feature in Ca II λ3945, an event also observed, although infrequently, in low-redshift SN Ia spectra (6 out of 22 SNe Ia in our local sample). Moreover, echoing the recent studies of Dessart & Hillier in the context of Type II supernovae (SNe II), we see similar P Cygni line profiles in our large sample of SN Ia spectra. First, the magnitude of the velocity location at maximum profile absorption may underestimate that at the continuum photosphere, as observed, for example, in the optically thinner line S II λ5640. Second, we report for the first time the unambiguous and systematic intrinsic blueshift of peak emission of optical P Cygni line profiles in SN Ia spectra, by as much as 8000 km s-1. All the high-z SNe Ia analyzed in this paper were discovered and followed up by the ESSENCE collaboration and are now publicly available. Based in part on observations obtained at the Cerro Tololo Inter-American Observatory, which is operated by the Association of Universities for Research in Astronomy (AURA), Inc., under cooperative agreement with the National Science Foundation (NSF); the European Southern Observatory, Chile (ESO program 170.A-0519) the Gemini Observatory, which is operated by AURA under a cooperative agreement with the NSF on behalf of the Gemini partnership (the NSF [United States], the Particle Physics and Astronomy Research Council [United Kingdom], the National Research Council [Canada], CONICYT [Chile], the Australian Research Council [Australia], CNPq [Brazil], and CONICET [Argentina]) (programs GN-2002B-Q-14, GN-2003B-Q-11, and GS-2003B-Q-11) the Magellan Telescopes at Las Campanas Observatory; the MMT Observatory, a joint facility of the Smithsonian Institution and the University of Arizona; and the F. L. Whipple Observatory, which is operated by the Smithsonian

  8. Development of methodology for alternative testing strategies for the assessment of the toxicological profile of nanoparticles used in medical diagnostics. NanoTEST - EC FP7 project

    International Nuclear Information System (INIS)

    Dusinska, Maria; Fjellsbo, Lise Maria; Heimstad, Eldbjorg; Harju, Mikael; Bartonova, Alena; Tran, Lang; Juillerat-Jeanneret, Lucienne; Halamoda, Blanka; Marano, Francelyne; Boland, Sonja; Saunders, Margaret; Cartwright, Laura; Carreira, Sara; Thawley, Susan; Whelan, Maurice; Klein, Christoph; Housiadas, Christos; Volkovova, Katarina; Tulinska, Jana; Beno, Milan

    2009-01-01

    Nanoparticles (NPs) have unique, potentially beneficial properties, but their possible impact on human health is still not known. The area of nanomedicine brings humans into direct contact with NPs and it is essential for both public confidence and the nanotech companies that appropriate risk assessments are undertaken in relation to health and safety. There is a pressing need to understand how engineered NPs can interact with the human body following exposure. The FP7 project NanoTEST (www.nanotest-fp7.eu) addresses these requirements in relation to the toxicological profile of NPs used in medical diagnostics.

  9. Stratum corneum profiles of inflammatory mediators in patch test reactions to common contact allergens and sodium lauryl sulfate.

    Science.gov (United States)

    Koppes, S A; Ljubojevic Hadzavdic, S; Jakasa, I; Franceschi, N; Jurakić Tončić, R; Marinović, B; Brans, R; Gibbs, S; Frings-Dresen, M H W; Rustemeyer, T; Kezic, S

    2017-06-01

    Recent studies have demonstrated allergen-specific differences in the gene expression of inflammatory mediators in patch tested skin. To determine levels of various inflammatory mediators in the stratum corneum (SC) after patch testing with common contact allergens and the skin irritant sodium lauryl sulfate (SLS). In total, 27 individuals who had previously patch tested positive to nickel, chromium, methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) or para-phenylenediamine were retested and then patch tested with SLS and petrolatum, with petrolatum serving as the patch test control. At 72 h, the test sites were clinically graded and the SC samples collected on adhesive tape. The levels of 18 of the 32 quantified mediators differed significantly from that of the control patches for at least one of the tested substances. SLS and MCI/MI induced the largest number of immunomediators. Interleukin (IL)-16 levels were significantly higher in patch test reactions in all allergens than they were in the controls, while no significant difference was detected for SLS. Furthermore, a strong negative correlation was found between strength of patch test reaction and IL-1α levels. Cytokine profiles in the SC of patch tested skin did not show a distinct allergen-specific pattern. However, MCI/MI induced a larger and wider immune response than the other allergens, perhaps due to its potency as an irritant. The levels of IL-16 were significantly increased in patch test reactions to allergens but not to SLS; thus, they may help clinicians to differentiate between allergic contact dermatitis and irritant contact dermatitis. © 2016 British Association of Dermatologists.

  10. Beam profile measurements on the advanced test accelerator using optical techniques

    International Nuclear Information System (INIS)

    Chong, Y.P.; Kalibjian, R.; Cornish, J.P.; Kallman, J.S.; Donnelly, D.

    1986-01-01

    Beam current density profiles of ATA have been measured both spatially and temporally using a number of diagnostics. An extremely important technique involves measuring optical emissions from either a target foil inserted into the beam path or gas atoms and molecules excited by beam electrons. This paper describes the detection of the optical emission. A 2-D gated television camera with a single or dual micro-channel-plate (MCP) detector for high gain provides excellent spatial and temporal resolution. Measurements are routinely made with resolutions of 1 mm and 5 ns respectively. The optical line of sight allows splitting part of the signal to a streak camera or photometer for even higher time resolution

  11. A Test of the Empirical Profile and Coherence of the DSM-5 Psychopathy Specifier.

    Science.gov (United States)

    Miller, Joshua D; Lamkin, Joanna; Maples-Keller, Jessica L; Sleep, Chelsea E; Lynam, Donald R

    2017-11-13

    The Diagnostic and Statistical Manual of Mental Disorders-5th edition (DSM-5; American Psychiatric Association, 2013) introduced a psychopathy specifier (DSM-5 PS) as part of the Section III diagnostic model of antisocial personality disorder. Designed to capture the construct of fearless dominance/boldness, the DSM-5 PS is assessed on the basis of the presence of low scores on traits of withdrawal and anxiousness, and high scores on attention seeking. These constructs have garnered attention in the past decade but are the subject of substantial debate as to their role in the conceptualization and assessment of psychopathy, given their limited relations to the maladaptive outcomes typically associated with this personality disorder. In the current study (N = 340 undergraduates; 170 informants), we examined the DSM-5 PS, both in composite form and its trait subscales, to investigate the degree to which the DSM-5 PS manifested empirical profiles associated with psychopathy and its maladaptive correlates. Consistent with prior fearless dominance/boldness research, the DSM-5 PS manifested limited relations with other components of psychopathy, symptoms of DSM-5 Section II and III antisocial personality disorder, and self- and informant-related impairment scores. When examined at the individual subscale level, the 3 DSM-5 PS subscales manifested only partially overlapping profiles and only 1 of the 3-Attention Seeking-demonstrated an association with maladaptivity (e.g., externalizing behaviors). These findings raise important concerns about the coherence and utility of the DSM-5 PS as a diagnostic specifier included in a psychiatric nosology. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  12. Experimental Tests on Bending Behavior of Profiled Steel Sheeting Dry Board Composite Floor with Geopolymer Concrete Infill

    Directory of Open Access Journals (Sweden)

    Mohd Isa Jaffar

    Full Text Available Abstract Profiled Steel Sheet Dry Board (PSSDB system is a lightweight composite structure comprises Profiled Steel Sheeting and Dry Board connected by self-drilling and self-tapping screws. This study introduced geopolymer concrete, an eco-friendly material without cement content as an infill material in the PSSDB floor system to highlight its effect onto the PSSDB (with full and half-size dry boards floor system's stiffness and strength. Experimental tests on various full scale PSSDB floor specimens were conducted under uniformly distributed transverse loads. Results illustrate that the rigidity of the panel with geopolymer concrete infill with half-size dry board (HBGPC increases by 43% relative to that of the panel with normal concrete infill with full-size dry board (FBNC. The developed finite-element modeling (FEM successfully predicts the behavior of FBGPC model with 94.8% accuracy. Geopolymer concrete infill and dry board size influence the strength panel, infill contact stiffness, and mid-span deflection of the profiled steel sheeting/dry board (PSSDB flooring system.

  13. Profiles of orofacial dysfunction in different diagnostic groups using the Nordic Orofacial Test (NOT-S)--a review.

    Science.gov (United States)

    Bergendal, Birgitta; Bakke, Merete; McAllister, Anita; Sjögreen, Lotta; Åsten, Pamela

    2014-11-01

    The Nordic Orofacial Test-Screening (NOT-S) was developed as a comprehensive method to assess orofacial function. Results from the screening protocol have been presented in 11 international publications to date. This study reviewed these publications in order to compile NOT-S screening data and create profiles of orofacial dysfunction that characterize various age groups and disorders. NOT-S results of nine reports meeting the inclusion criteria were reviewed. Seven of these studies not only provided data on the mean and range of total NOT-S scores, but also on the most common domains of orofacial dysfunction (highest rate of individuals with dysfunction scores), allowing the construction of orofacial dysfunction profiles based on the prevalence of dysfunction in each domain of NOT-S. The compiled data comprised 669 individuals, which included healthy control subjects (n = 333) and various patient groups (n = 336). All studies reported differences between individuals with diagnosed disorders and healthy control subjects. The NOT-S data could measure treatment effects and provided dysfunction profiles characterizing the patterns of orofacial dysfunction in various diagnoses. This review corroborates previous results that the NOT-S differentiates well between patients and healthy controls and can also show changes in individuals after treatment. NOT-S could be used as a standard instrument to assess orofacial dysfunction, evaluate the outcomes of oral habilitation and rehabilitation and improve comparability in clinical practice and research.

  14. Epigenomics: dissecting hybridization and polyploidization.

    Science.gov (United States)

    Jackson, Scott A

    2017-06-19

    Epigenetic profiling in diploid, allopolyploid, and domesticated cotton shows that despite most DNA methylation being conserved and stably inherited, alterations likely due to hybridization and domestication affect gene expression.

  15. Electric/Hybrid Vehicle Simulation

    Science.gov (United States)

    Slusser, R. A.; Chapman, C. P.; Brennand, J. P.

    1985-01-01

    ELVEC computer program provides vehicle designer with simulation tool for detailed studies of electric and hybrid vehicle performance and cost. ELVEC simulates performance of user-specified electric or hybrid vehicle under user specified driving schedule profile or operating schedule. ELVEC performs vehicle design and life cycle cost analysis.

  16. The development of fuel pins and material specimens mixed loading irradiation test rig in the experimental fast reactor Joyo. The development of the fuel-material hybrid rig

    International Nuclear Information System (INIS)

    Oyamatsu, Yasuko; Someya, Hiroyuki

    2013-02-01

    In the experimental fast reactor Joyo, there were many tests using the irradiation rigs that it was possible to be set irradiation conditions for each compartment independently. In case of no alternative fuel element to irradiate after unloading the irradiated compartments, the irradiation test was restarted with the dummy compartment which the fuel elements was not mounted. If the material specimens are mounted in this space, it is possible to use the irradiation space effectively. For these reasons, the irradiation rig (hybrid rig) is developed that is consolidated with material specimens compartment and fuel elements compartment. Fuel elements and material specimens differ greatly with heat generation, so that the most important issue in developing of hybrid rig is being able to distribute appropriately the coolant flow which satisfies irradiation conditions. The following is described by this report. (1) It was confirmed that the flow distribution of loading the same irradiation rig with the compartment from which a flow demand differs could be satisfied. (2) It was confirmed that temperature setting range of hybrid rig could be equivalent to that of irradiation condition. (3) By standardizing the coolant entrance structure of the compartment lower part, the prospect which can perform easily recombination of the compartment from which a type differs between irradiation rigs was acquired. (author)

  17. Test methods for evaluating energy consumption and emissions of vehicles with electric, hybrid and fuel cell power trains

    NARCIS (Netherlands)

    Smokers, R.T.M.; Ploumen, S.; Conte, M.; Buning, L.; Meier-Engel, K.

    2000-01-01

    As part of the MATADOR-project measurement methods have been developed for the evaluation of the energy consumption and emissions of vehicles with advanced propulsion systems, such as battery-electric, hybrid electric and fuel cell vehicles. Based on an inventory of existing and prospective standard

  18. Corrosion Characteristics of Inconel-600 at the NP(Cu)-HYBRID Decontamination Demonstration Test with HANARO FTL Specimen

    Energy Technology Data Exchange (ETDEWEB)

    Jung, Jun Young; Park, Sang Yoon; Won, Hui Jun; Kim, Seon Byeong; Choi, Wang Kyu; Moon, Jei Kwon [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2013-10-15

    An alkaline permanganate (AP) or nitric permanganate (NP) oxidative phase has been generally used to dissolve the chromium-rich oxide. AP is advantageous for the corrosion resistance, but increases the volume of secondary waste during the decontamination procedure. On the other hand, NP has a high corrosion rate but reduces secondary waste. For the safe use of an oxidative decontamination solution with high corrosive resistance and less amount of secondary waste are required. In this study, we modified NP oxidative decontamination solution by adding Cu{sup 2+} to reduce the corrosion rate. To evaluate the general corrosion characteristics, we measured the weight losses of selected specimens in an NP(Cu) and other solutions. The localized corrosion was observed using an optical microscope (OM). To compare the decontamination performance, we measured the contact dose rate of specimens treated in NP-HYBRID and NP(Cu)-HYBRID systems. The reduced corrosion characteristics of the Inconel-600 specimen in a NP(Cu) oxidative solution was observed in terms of generalized corrosion as well as localized corrosion. Less corrosion characteristics do not affect the performance of the overall decontamination compared to the NP-HYBRID process. Therefore, our results support that the NP(Cu)-HYBRID decontamination process is appropriate for the decontamination of the primary coolant system in a nuclear reactor.

  19. Analysis of non-regulated vehicular emissions by extractive FTIR spectrometry: tests on a hybrid car in Mexico City

    Science.gov (United States)

    Reyes, F.; Grutter, M.; Jazcilevich, A.; González-Oropeza, R.

    2006-07-01

    A methodology to acquire valuable information on the chemical composition and evolution of vehicular emissions is presented. The analysis of the gases is performed by passing a constant flow of a sample gas from the tail-pipe into a 10 L multi-pass cell. The absorption spectra within the cell are obtained using an FTIR spectrometer at 0.5 cm-1 resolution along a 13.1 m optical path. Additionally, the total flow from the exhaust is continuously measured from a differential pressure sensor on a Pitot tube installed at the exit of the exhaust. This configuration aims to obtain a good speciation capability by coadding spectra during 30 s and reporting the emission (in g/km) of key and non-regulated pollutants, such as CO2, CO, NO, SO2, NH3, HCHO, NMHC, during predetermined driving routines. The advantages and disadvantages of increasing the acquisition frequency, as well as the effect of other parameters such as spectral resolution, cell volume and flow rate, are discussed. With the aim of testing and evaluating the proposed technique, experiments were performed on a dynamometer running FTP-75 and typical driving cycles of the Mexico City Metropolitan Area (MCMA) on a Toyota Prius hybrid vehicle. This car is an example of recent automotive technology to reach the market dedicated to reduce emissions and therefore pressing the need of low detection techniques. This study shows the potential of the proposed technique to measure and report in real time the emissions of a large variety of pollutants, even from a super ultra-low emission vehicle (SULEV). The emissions of HC's, NOx, CO and CO2 obtained here are similar to experiments performed in other locations with the same vehicle model. Some differences suggest that an inefficient combustion process and type of gasoline used in the MCMA may be partly responsible for lower CO2 and higher CO and NO emission factors. Also, a fast reduction of NO emission to very low values is observed after cold ignition, giving rise to

  20. New Hypervariable SSR Markers for Diversity Analysis, Hybrid Purity Testing and Trait Mapping in Pigeonpea [Cajanus cajan (L.) Millspaugh].

    Science.gov (United States)

    Bohra, Abhishek; Jha, Rintu; Pandey, Gaurav; Patil, Prakash G; Saxena, Rachit K; Singh, Indra P; Singh, D; Mishra, R K; Mishra, Ankita; Singh, F; Varshney, Rajeev K; Singh, N P

    2017-01-01

    Draft genome sequence in pigeonpea offers unprecedented opportunities for genomics assisted crop improvement via enabling access to genome-wide genetic markers. In the present study, 421 hypervariable simple sequence repeat (SSR) markers from the pigeonpea genome were screened on a panel of eight pigeonpea genotypes yielding marker validation and polymorphism percentages of 95.24 and 54.11%, respectively. The SSR marker assay uncovered a total of 570 alleles with three as an average number of alleles per marker. Similarly, the mean values for gene diversity and PIC were 0.44 and 0.37, respectively. The number of polymorphic markers ranged from 39 to 89 for different parental combinations. Further, 60 of these SSRs were assayed on 94 genotypes, and model based clustering using STRUCTURE resulted in the identification of the two subpopulations ( K = 2). This remained in close agreement with the clustering patterns inferred from genetic distance (GD)-based approaches i.e., dendrogram, factorial and principal coordinate analysis (PCoA). The AMOVA accounted majority of the genetic variation within groups (89%) in comparison to the variation existing between the groups (11%). A subset of these markers was implicated for hybrid purity testing. We also demonstrated utility of these SSR markers in trait mapping through association and bi-parental linkage analyses. The general linear (GLM) and mixed linear (MLM) models both detected a single SSR marker (CcGM03681) with R 2 = 16.4 as associated with the resistance to Fusarium wilt variant 2. Similarly, by using SSR data in a segregating backcross population, the corresponding restorer-of-fertility ( Rf ) locus was putatively mapped at 39 cM with the marker CcGM08896. However, The marker-trait associations (MTAs) detected here represent a very preliminary type and hence demand deeper investigations for conclusive evidence. Given their ability to reveal polymorphism in simple agarose gels, the hypervariable SSRs are valuable

  1. Optimal Threshold for a Positive Hybrid Capture 2 Test for Detection of Human Papillomavirus: Data from the ARTISTIC Trial▿

    Science.gov (United States)

    Sargent, A.; Bailey, A.; Turner, A.; Almonte, M.; Gilham, C.; Baysson, H.; Peto, J.; Roberts, C.; Thomson, C.; Desai, M.; Mather, J.; Kitchener, H.

    2010-01-01

    We present data on the use of the Hybrid Capture 2 (HC2) test for the detection of high-risk human papillomavirus (HR HPV) with different thresholds for positivity within a primary screening setting and as a method of triage for low-grade cytology. In the ARTISTIC population-based trial, 18,386 women were screened by cytology and for HPV. Cervical intraepithelial neoplasia lesions of grade two and higher (CIN2+ lesions) were identified for 453 women within 30 months of an abnormal baseline sample. When a relative light unit/cutoff (RLU/Co) ratio of ≥1 was used as the threshold for considering an HC2 result positive, 15.6% of results were positive, and the proportion of CIN2+ lesions in this group was 14.7%. The relative sensitivity for CIN2+ lesion detection was 93.4%. When an RLU/Co ratio of ≥2 was used as the threshold, there was a 2.5% reduction in positivity, with an increase in the proportion of CIN2+ lesions detected. The relative sensitivity decreased slightly, to 90.3%. Among women with low-grade cytology, HPV prevalences were 43.7% and 40.3% at RLU/Co ratios of ≥1 and ≥2, respectively. The proportions of CIN2+ lesions detected were 17.3% and 18.0%, with relative sensitivities of 87.7% at an RLU/Co ratio of ≥1 and 84.2% at an RLU/Co ratio of ≥2. At an RLU/Co ratio of ≥1, 68.3% of HC2-positive results were confirmed by the Roche line blot assay, compared to 77.2% of those at an RLU/Co ratio of ≥2. Fewer HC2-positive results were confirmed for 35- to 64-year-olds (50.3% at an RLU/Co ratio of ≥1 and 63.2% at an RLU/Co ratio of >2) than for 20- to 34-year-olds (78.7% at an RLU/Co ratio of ≥1 and 83.7% at an RLU/Co ratio of >2). If the HC2 test is used for routine screening as an initial test or as a method of triage for low-grade cytology, we would suggest increasing the threshold for positivity from the RLU/Co ratio of ≥1, recommended by the manufacturer, to an RLU/Co ratio of ≥2, since this study has shown that a beneficial balance

  2. Relationship between the COI test and other sensory profiles by statistical procedures

    Directory of Open Access Journals (Sweden)

    Calvente, J. J.

    1994-04-01

    Full Text Available Relationships between 139 sensory attributes evaluated on 32 samples of virgin olive oil have been analysed by a statistical sensory wheel that guarantees the objectiveness and prediction of its conclusions concerning the best clusters of attributes: green, bitter-pungent, ripe fruit, fruity, sweet fruit, undesirable attributes and two miscellanies. The procedure allows the sensory notes evaluated for potential consumers of this edible oil from the point of view of its habitual consumers to be understood with special reference to The European Communities Regulation n-2568/91. Five different panels: Spanish, Greek, Italian, Dutch and British, have been used to evaluate the samples. Analysis of the relationships between stimuli perceived by aroma, flavour, smell, mouthfeel and taste together with Linear Sensory Profiles based on Fuzzy Logic are provided. A 3-dimensional plot indicates the usefulness of the proposed procedure in the authentication of different varieties of virgin olive oil. An analysis of the volatile compounds responsible for most of the attributes gives weight to the conclusions. Directions which promise to improve the E.G. Regulation on the sensory quality of olive oil are also given.

  3. Profiles of Attendees in Voluntary Counseling and Testing Centers of a Medical College Hospital in Coastal Karnataka

    Science.gov (United States)

    Jayarama, S; Shenoy, Shaliny; Unnikrishnan, B; Ramapuram, John; Rao, Manjula

    2008-01-01

    Research Question: What are the socio-demographic profile and risk behavior pattern of seropositive attendees in the voluntary counseling and testing center (VCTC)? Study Design: Retrospective study. Setting: VCTC in the outpatient complex of Kasturba Medical College Hospital, Mangalore, Karnataka. Subjects: Records pertaining to all the 539 and 330 seropositive attendees during the years 2005 and 2006, respectively, were included in the study besides data from 2001 onwards in order to assess the time trend of human immunodeficiency virus (HIV). Study Variables: Age, sex, marital status, religion, educational status, occupation, place of residence and pattern of risk behavior in relation to HIV/AIDS. Statistical Analysis: Analysis was done with SPSS version 11. Statistical test and Chi-square was done, and P profile, about 17-27% were housewives, 19-21% were laborers/hotel workers and 7% were entrepreneurs. About 45% were from urban area and nearly one-third hailing from other districts in the border of Karnataka. About 25% were exposed to commercial sex workers; another 21-23% were involved in premarital sex and nearly 38% were indulging in heterosexual activities. PMID:19966996

  4. Comparison of ring-focus image profile with predictions for the AXAF VETA-I test

    Science.gov (United States)

    Zissa, David E.

    1993-01-01

    The X-ray test of the largest pair of nearly cylindrical mirrors for the Advanced X-ray Astrophysics Facility (AXAF) was completed in October 1991 at Marshall Space Flight Center. The test assembly was named the Verification Engineering Test Article I (VETA-I). The ring-focus portion of the test measured the imaging quality of azimuthal sections of VETA-I. This gives information about the core of the on-orbit image. The finite source distance, VETA-I mirror spacing, and VETA-I structural deformation caused the core of the image to be spread over a diameter of nearly 4 arc seconds at the VETA-I overall focus. The results of a preliminary analysis of the ring-focus data and the implications for the on-orbit image of the telescope are discussed. An upper limit for the on-orbit encircled-energy fraction at 1 arc second diameter was determined to be 0.82 at 0.277 keV X-ray energy. This assumes that the bottoms of the mirrors in the VETA-I arrangement are representative of the mirror surfaces and that the on-orbit system would be aligned using a combination of preliminary measurements and predictions for the mirror surface shapes.

  5. A method for crack profiles identification in eddy current testing by the multi-directional scan

    International Nuclear Information System (INIS)

    Kojima, Fumio; Ikeda, Takuya; Nguyen, Doung

    2006-01-01

    This paper is concerned with a method for identification of crack shape in conducting materials. Multi-directional scanning strategies using Eddy Current Testing is performed for sizing complex natural crackings. Two dimensional measurements by means of multi-directional scan are used in a output least square identifications. (author)

  6. Behavioral profiles of genetically selected aggressive and nonaggressive male wild house mice in two anxiety tests

    NARCIS (Netherlands)

    Hogg, S; Wurbel, H; Steimer, T; de Ruiter, A; Koolhaas, J; Sluyter, F; Driscoll, Peter

    2000-01-01

    Artificially selected aggressive (SAL) and non-aggressive (LAL) male house mice were tested in a hexagonal tunnel maze and light-dark preference (LD) box to determine if the bidirectional selection for aggressive behavior leads to a coselection for different levels of trait anxiety. The tunnel maze

  7. How Informative are the Vertical Buoyancy and the Prone Gliding Tests to Assess Young Swimmers’ Hydrostatic and Hydrodynamic Profiles?

    Science.gov (United States)

    Barbosa, Tiago M.; Costa, Mário J.; Morais, Jorge E; Moreira, Marc; Silva, António J.; Marinho, Daniel A.

    2012-01-01

    The aim of this research was to develop a path-flow analysis model to highlight the relationships between buoyancy and prone gliding tests and some selected anthropometrical and biomechanical variables. Thirty-eight young male swimmers (12.97 ± 1.05 years old) with several competitive levels were evaluated. It were assessed the body mass, height, fat mass, body surface area, vertical buoyancy, prone gliding after wall push-off, stroke length, stroke frequency and velocity after a maximal 25 [m] swim. The confirmatory model included the body mass, height, fat mass, prone gliding test, stroke length, stroke frequency and velocity. All theoretical paths were verified except for the vertical buoyancy test that did not present any relationship with anthropometrical and biomechanical variables nor with the prone gliding test. The good-of-fit from the confirmatory path-flow model, assessed with the standardized root mean square residuals (SRMR), is considered as being close to the cut-off value, but even so not suitable of the theory (SRMR = 0.11). As a conclusion, vertical buoyancy and prone gliding tests are not the best techniques to assess the swimmer’s hydrostatic and hydrodynamic profile, respectively. PMID:23486528

  8. Compression test of cold-formedsteel perforated profile with steel sheathing

    Directory of Open Access Journals (Sweden)

    Shamanin Aleksandr Yur’evich

    2015-05-01

    Full Text Available The subject of this paper is the stability and strength of cold-formed and perforated steel sigma-section columns with steel sheathing of different thickness. Ceilings with and without steel sheathing of different thickness are tested to failure in compression on a laboratory machine, which was based on a manual hydraulic jack. Series of 4 experiments with full-scale walls (2.5 m height were carried out. Also, for examination of the role of boundary conditions, the sheet in a ceiling is either left free or connected to base with screws.In civil engineering there are many experiments and methodologies for calculating the strength and buckling of ceiling with the sheathing of various materials, such as oriented strand board and gypsum board. However, for producing superstructures of ships the materials with high plastic properties and strength characteristics are required. For example steel possesses such properties. It was the main reason for conducting a series of experiments and studying the behavior of cold-formed steel columns with steel sheathing. During the experiments the deformation of the cross-section of three equally spaced cross sections was determined, as well as the axial deformation of the central column in the ceiling with steel sheathing.The test results showed the influence of the thickness of sheathing and boundary condition of a sheet on the strength and buckling of ceiling. According to the results of the tests it is necessary to evaluate the impact of the sheathing made of different materials and if necessary to carry out further tests.

  9. Profile of irritant patch testing with detergents: sodium lauryl sulfate, sodium laureth sulfate and alkyl polyglucoside.

    Science.gov (United States)

    Löffler, H; Happle, R

    2003-01-01

    The cutaneous reaction to detergents follows distinct kinetic rules: the duration of application and the irritant concentration are of major importance. The aim of this study was to evaluate the differences in kinetics of skin reaction between the standard irritant sodium lauryl sulfate (SLS), and 2 modern detergents: sodium laureth sulfate (SLES) and alkyl polyglucoside (APG). We performed patch testing with SLS and SLES (or APG) at different concentrations (0.125, 0.25, 0.5, 1.0 and 2.0%) and with different exposure times (6, 12 and 24 h). Evaluation was conducted by measurement of transepidermal water loss (TEWL) and laser Doppler flowmetry (LD) 24 h, 7 and 10 days after patch removal. We found a pronounced reaction to SLS, and a far milder one to SLES. Even at the highest concentration the skin reaction to APG was hard to detect. During the regeneration period (day 3-10) SLS showed even at day 10 an increased TEWL at all concentrations tested. The irritation due to SLES was convincingly detectable only up to day 7, whereas the APG-tested skin areas showed no significant reaction even at day 3. These results demonstrate the improvement in reduction of skin irritation achieved by development of novel detergents.

  10. Multi-Wave and Hybrid Imaging Techniques: A New Direction for Nondestructive Testing and Structural Health Monitoring

    Directory of Open Access Journals (Sweden)

    Yuhua Cheng

    2013-11-01

    Full Text Available In this article, the state-of-the-art multi-wave and hybrid imaging techniques in the field of nondestructive evaluation and structural health monitoring were comprehensively reviewed. A new direction for assessment and health monitoring of various structures by capitalizing the advantages of those imaging methods was discussed. Although sharing similar system configurations, the imaging physics and principles of multi-wave phenomena and hybrid imaging methods are inherently different. After a brief introduction of nondestructive evaluation (NDE , structure health monitoring (SHM and their related challenges, several recent advances that have significantly extended imaging methods from laboratory development into practical applications were summarized, followed by conclusions and discussion on future directions.

  11. Charging and discharging tests for obtaining an accurate dynamic electro-thermal model of high power lithium-ion pack system for hybrid and EV applications

    DEFF Research Database (Denmark)

    Mihet-Popa, Lucian; Camacho, Oscar Mauricio Forero; Nørgård, Per Bromand

    2013-01-01

    This paper presents a battery test platform including two Li-ion battery designed for hybrid and EV applications, and charging/discharging tests under different operating conditions carried out for developing an accurate dynamic electro-thermal model of a high power Li-ion battery pack system....... The aim of the tests has been to study the impact of the battery degradation and to find out the dynamic characteristics of the cells including nonlinear open circuit voltage, series resistance and parallel transient circuit at different charge/discharge currents and cell temperature. An equivalent...... circuit model, based on the runtime battery model and the Thevenin circuit model, with parameters obtained from the tests and depending on SOC, current and temperature has been implemented in MATLAB/Simulink and Power Factory. A good alignment between simulations and measurements has been found....

  12. NEW CONCEPTS AND TEST METHODS OF CURVE PROFILE AREA DENSITY IN SURFACE: ESTIMATION OF AREAL DENSITY ON CURVED SPATIAL SURFACE

    OpenAIRE

    Hong Shen

    2011-01-01

    The concepts of curve profile, curve intercept, curve intercept density, curve profile area density, intersection density in containing intersection (or intersection density relied on intersection reference), curve profile intersection density in surface (or curve intercept intersection density relied on intersection of containing curve), and curve profile area density in surface (AS) were defined. AS expressed the amount of curve profile area of Y phase in the unit containing surface area, S...

  13. Emotional profiles to the Rorschach test in subjects affected by Central Serous Chorioretinopathy: preliminary observations

    Directory of Open Access Journals (Sweden)

    Giovanna Gioffrè

    2013-05-01

    Full Text Available Psychological variables could be related to disorders of vision with particular interest of depressive feautures, but with little attention to dimensions such as stress and anxiety. Psychological stress associated with hyperactivation of the sympathetic autonomic nervous system, is considered the most important risk factor of a rare disorder of vision, the Central Serous Chorioretinopathy (CSC, whose etiology has not yet been clarified. This study to examine the psychological literature regarding to CSC and explore in a preliminary the projective methods of the Rorschach test, any correlations between personality variables and predisposition to CSC.

  14. COMPARATIVE RESEARCHE REGARDING METABOLIC PROFILE OF THE CALIFORNIAN, NEW ZEALAND WHITE, GRAND CHINCHILLA MEAT RABIT BREEDS AND THE F1 NZCH HYBRIDS

    Directory of Open Access Journals (Sweden)

    DANIELA-MARCELA TOBĂ (GOINA

    2008-10-01

    Full Text Available Precious biological characteristics of rabbits make their breeding a very profitable occupation. The rabbit meat, organoleptically same to the white meat, is rich in proteins, but low in fats. Biological researched done in direction to elucidate the biochemical systems that are the basis for organism physiological processes, have revealed that the level in which this process are develop directly influence the rabbits productivity capacity. 60 rabbit’s heads was used as biological material, distributed in: 15 Californian, 15 New Zeeland White, 15 Grand Chinchilla and 15 F1NZCH hybrids obtained from cross-breeding the New Zeeland White as maternal form and Grand Chinchilla as paternal form. Blood was sampled from the rabbit and was biochemical analyzed. The studied indices were: total protein, albumin, urea, uric acid, creatinine, total bilirubine, cholesterol, triglyceride and glucose. The experimental lot formed from F1 NZCH hybrids registered a concentration of 2.1 mg/dl uric acid, and in the other three lots the concentration was under 2 mg/dl. In all four lots, uric acid value was in normal limits. The determined creatinine registered very low values, under 1 mg/dl, at the low limit of reference values. At hybrids from New Zeeland White as maternal form and Grand Chinchilla as paternal form, in equal environmental conditions, the serum biochemical analysis haven’t registered significant differences compared to pure breeds individuals.

  15. Detection Of Cracks In Composite Materials Using Hybrid Non-Destructive Testing Method Based On Vibro-Thermography And Time-Frequency Analysis Of Ultrasonic Excitation Signal

    Directory of Open Access Journals (Sweden)

    Prokopowicz Wojciech

    2015-09-01

    Full Text Available The theme of the publication is to determine the possibility of diagnosing damage in composite materials using vibrio-thermography and frequency analysis and time-frequency of excitation signal. In order to verify the proposed method experiments were performed on a sample of the composite made in the technology of pressing prepregs. Analysis of the recorded signals and the thermograms were performed in MatLab environment. Hybrid non-destructive testing method based on thermogram and appropriate signal processing algorithm clearly showed damage in the sample composite material.

  16. Définition d’un profil d’apprenant en situation d’auto-évaluation Visualization of Learner’s Profile in Self-Testing Situation

    Directory of Open Access Journals (Sweden)

    Philippe Teutsch

    2000-06-01

    Full Text Available Ce texte présente un projet de recherche pluridisciplinaire (didactique du FLE et EIAO centré sur la modélisation de l’apprenant. Le système GCSE valide les compétences d’un public placé en situation d’évaluation par un environnement multimédia de test des habiletés linguistiques. Le repérage et le classement des erreurs par le système permettent de constituer des corpus de fautes rendus accessibles avec leur contexte de production. On dispose ainsi d’éléments nécessaires à la constitution d’un profil par la mise en forme de différents niveaux : validation de la compétence globale, performances spécifiques dans telle partie du texte, types d’erreurs récurrents, corpus constitués des fautes rencontrées. Les outils mis en place ont pour but d’aider l’utilisateur à construire un parcours d’auto-évaluation : relecture des activités, mise en relation d’éléments originellement séparés. Ils permettent également à un évaluateur de disposer d’indices pertinents quant au niveau de performance atteint par l’apprenant.Our paper will present a pluridisciplinarial research (French as a Foreign Language, AIED centered on learner’s modeling in language learning. The system in development (GSCE validates the competences in a situation of skills evaluation by using an Internet site. The aim of the project is to set an interactive environment to strength motivation of the learner by providing self-evaluation tools. The work of conception and development stress the error analysis, specifically in short answers to open questions, so as their visualization under synthetic forms aiming learners as well as teachers. The localization and the classification of these mistakes by the system allows a visual restitution in the context of their production

  17. Characterisation of aroma profiles of commercial soy sauce by odour activity value and omission test.

    Science.gov (United States)

    Feng, Yunzi; Su, Guowan; Zhao, Haifeng; Cai, Yu; Cui, Chun; Sun-Waterhouse, Dongxiao; Zhao, Mouming

    2015-01-15

    Twenty-seven commercial soy sauces produced through three different fermentation processes (high-salt liquid-state fermentation soy sauce, HLFSS; low-salt solid-state fermentation soy sauce, LSFSS; Koikuchi soy sauce, KSS) were examined to identify the aroma compounds and the effect of fermentation process on the flavour of the soy sauce was investigated. Results showed that 129 volatiles were identified, of which 41 aroma-active components were quantified. The types of odorants occurring in the three soy sauce groups were similar, although their intensities significantly differed. Many esters and phenols were found at relatively high intensities in KSS, whereas some volatile acids only occurred in LSFSS. Furthermore, 23 aroma compounds had average OAVs>1, among which 3-methylbutanal, ethyl acetate, 4-hydroxy-2-ethyl-5-methyl-3(2H)-furanone, 2-methylbutanal and 3-(methylthio)propanal exhibited the highest average OAVs (>100). In addition, omission tests verified the important contribution of the products resulting from amino acid catabolism to the characteristic aroma of soy sauce. Copyright © 2014. Published by Elsevier Ltd.

  18. Comparison of clinical and analytical performance of the Abbott Realtime High Risk HPV test to the performance of hybrid capture 2 in population-based cervical cancer screening.

    Science.gov (United States)

    Poljak, Mario; Ostrbenk, Anja; Seme, Katja; Ucakar, Veronika; Hillemanns, Peter; Bokal, Eda Vrtacnik; Jancar, Nina; Klavs, Irena

    2011-05-01

    The clinical performance of the Abbott RealTime High Risk HPV (human papillomavirus) test (RealTime) and that of the Hybrid Capture 2 HPV DNA test (hc2) were prospectively compared in the population-based cervical cancer screening setting. In women >30 years old (n = 3,129), the clinical sensitivity of RealTime for detection of cervical intraepithelial neoplasia of grade 2 (CIN2) or worse (38 cases) and its clinical specificity for lesions of less than CIN2 (3,091 controls) were 100% and 93.3%, respectively, and those of hc2 were 97.4% and 91.8%, respectively. A noninferiority score test showed that the clinical specificity (P laboratories. RealTime can be considered to be a reliable and robust HPV assay clinically comparable to hc2 for the detection of CIN2+ lesions in a population-based cervical cancer screening setting.

  19. Extended device profiles and testing procedures for the approval process of integrated medical devices using the IEEE 11073 communication standard.

    Science.gov (United States)

    Janß, Armin; Thorn, Johannes; Schmitz, Malte; Mildner, Alexander; Dell'Anna-Pudlik, Jasmin; Leucker, Martin; Radermacher, Klaus

    2018-02-23

    Nowadays, only closed and proprietary integrated operating room systems (IORS) from big manufacturers are available on the market. Hence, the interconnection of components from third-party vendors is only possible with increased time and costs. In the context of the German Federal Ministry of Education and Research (BMBF)-funded project OR.NET (2012-2016), the open integration of medical devices from different manufacturers was addressed. An integrated operating theater based on the open communication standard IEEE 11073 shall give clinical operators the opportunity to choose medical devices independently of the manufacturer. This approach would be advantageous especially for hospital operators and small- and medium-sized enterprises (SME) of medical devices. Actual standards and concepts regarding technical feasibility and the approval process do not cope with the requirements for a modular integration of medical devices in the operating room (OR), based on an open communication standard. Therefore, innovative approval strategies and corresponding certification and test procedures, which cover actual legal and normative standards, have to be developed in order to support the future risk management and the usability engineering process of open integrated medical devices in the OR. The use of standardized device and service profiles and a three-step testing procedure, including conformity, interoperability and integration tests are described in this paper and shall support the manufacturers to integrate their medical devices without disclosing the medical devices' risk analysis and related confidential expertise or proprietary information.

  20. Hybrid choice model to disentangle the effect of awareness from attitudes: Application test of soft measures in medium size city

    DEFF Research Database (Denmark)

    Sottile, Eleonora; Meloni, Italo; Cherchi, Elisabetta

    2017-01-01

    The need to reduce private vehicle use has led to the development of soft measures aimed at re-educating car users through information processes that raise their awareness about the benefits of environmentally friendly modes, encouraging them to voluntarily change their travel choice behaviour......), carried out with the purpose of promoting the use of the light rail in Park and Ride mode. To account for all these effects in the choice between car and Park and Ride we estimate a Hybrid Choice Model where the discrete choice structure allows us to estimate the effect of awareness of environment...

  1. UV irradiation as a tool for obtaining asymmetric somatic hybrids between Nicotiana plumbaginifolia and Lycopersicon esculentum

    International Nuclear Information System (INIS)

    Vlahova, M.; Hinnisdaels, S.; Frulleux, F.; Claeys, M.; Atanassov, A.; Jacobs, M.

    1997-01-01

    UV-irradiated kanamycin-resistant Lycopersicon esculentum leaf protoplasts were fused with wild-type Nicotiana plumbaginifolia leaf protoplasts. Hybrid calli were recovered after selection in kanamycin-containing medium and subsequently regenerated. Cytological analysis of these regenerants showed that several (2–4) tomato chromosomes, or chromosome fragments, were present in addition to a polyploid Nicotiana genome complement. All lines tested had neomycin phosphotransferase (NPTII) activity and the presence of the kanamycin gene was shown by Southern blotting. In two cases a different hybridization profile for the kanamycin gene, compared to the tomato donor partner, was observed, suggesting the occurence of intergenomic recombination events. The hybrid nature of the regenerants was further confirmed by Southernblotting experiments using either a ribosomal DNA sequence or a tomato-specific repeat as probes. The hybrids were partially fertile and some progeny could be obtained. Our results demonstrate that UV irradiation is a valuable alternative for asymmetric cell-hybridization experiments. (author)

  2. Cohort profile: seek, test, treat and retain United States criminal justice cohort.

    Science.gov (United States)

    Chandler, Redonna; Gordon, Michael S; Kruszka, Bridget; Strand, Lauren N; Altice, Frederick L; Beckwith, Curt G; Biggs, Mary L; Cunningham, William; Chris Delaney, J A; Flynn, Patrick M; Golin, Carol E; Knight, Kevin; Kral, Alex H; Kuo, Irene; Lorvick, Jennifer; Nance, Robin M; Ouellet, Lawrence J; Rich, Josiah D; Sacks, Stanley; Seal, David; Spaulding, Anne; Springer, Sandra A; Taxman, Faye; Wohl, David; Young, Jeremy D; Young, Rebekah; Crane, Heidi M

    2017-05-16

    The STTR treatment cascade provides a framework for research aimed at improving the delivery of services, care and outcomes of PLWH. The development of effective approaches to increase HIV diagnoses and engage PLWH in subsequent steps of the treatment cascade could lead to earlier and sustained ART treatment resulting in viral suppression. There is an unmet need for research applying the treatment cascade to improve outcomes for those with criminal justice involvement. The Seek, Test, Treat, and Retain (STTR) criminal justice (CJ) cohort combines data from 11 studies across the HIV treatment cascade that focused on persons involved in the criminal justice system, often but not exclusively for reasons related to substance use. The studies were conducted in a variety of CJ settings and collected information across 11 pre-selected domains: demographic characteristics, CJ involvement, HIV risk behaviors, HIV and/or Hepatitis C infections, laboratory measures of CD4 T-cell count (CD4) and HIV RNA viral load (VL), mental illness, health related quality of life (QoL), socioeconomic status, health care access, substance use, and social support. The STTR CJ cohort includes data on 11,070 individuals with and without HIV infection who range in age from 18 to 77 years, with a median age at baseline of 37 years. The cohort reflects racial, ethnic and gender distributions in the U.S. CJ system, and 64% of participants are African-American, 12% are Hispanic and 83% are men. Cohort members reported a wide range of HIV risk behaviors including history of injection drug use and, among those who reported on pre-incarceration sexual behaviors, the prevalence of unprotected sexual intercourse ranged across studies from 4% to 79%. Across all studies, 53% percent of the STTR CJ cohort reported recent polysubstance use. The STTR CJ cohort is comprised of participants from a wide range of CJ settings including jail, prison, and community supervision who report considerable diversity in

  3. Comparison of global brain gene expression profiles between inbred long-sleep and inbred short-sleep mice by high-density gene array hybridization.

    Science.gov (United States)

    Xu, Y; Ehringer, M; Yang, F; Sikela, J M

    2001-06-01

    Inbred long-sleep (ILS) and short-sleep (ISS) mice show significant central nervous system-mediated differences in sleep time for sedative dose of ethanol and are frequently used as a rodent model for ethanol sensitivity. In this study, we have used complementary DNA (cDNA) array hybridization methodology to identify genes that are differentially expressed between the brains of ILS and ISS mice. To carry out this analysis, we used both the gene discovery array (GDA) and the Mouse GEM 1 Microarray. GDA consists of 18,378 nonredundant mouse cDNA clones on a single nylon filter. Complex probes were prepared from total brain mRNA of ILS or ISS mice by using reverse transcription and 33P labeling. The labeled probes were hybridized in parallel to the gene array filters. Data from GDA experiments were analyzed with SQL-Plus and Oracle 8. The GEM microarray includes 8,730 sequence-verified clones on a glass chip. Two fluorescently labeled probes were used to hybridize a microarray simultaneously. Data from GEM experiments were analyzed by using the GEMTools software package (Incyte). Differentially expressed genes identified from each method were confirmed by relative quantitative reverse transcription-polymerase chain reaction (RT-PCR). A total of 41 genes or expressed sequence tags (ESTs) display significant expression level differences between brains of ILS and ISS mice after GDA, GEM1 hybridization, and quantitative RT-PCR confirmation. Among them, 18 clones were expressed higher in ILS mice, and 23 clones were expressed higher in ISS mice. The individual gene or EST's function and mapping information have been analyzed. This study identified 41 genes that are differentially expressed between brains of ILS and ISS mice. Some of them may have biological relevance in mediation of phenotypic variation between ILS and ISS mice for ethanol sensitivity. This study also demonstrates that parallel gene expression comparison with high-density cDNA arrays is a rapid and

  4. Involvement of an ABI-like protein and a Ca2+-ATPase in drought tolerance as revealed by transcript profiling of a sweetpotato somatic hybrid and its parents Ipomoea batatas (L.) Lam. and I. triloba L.

    Science.gov (United States)

    Yang, Yufeng; Wang, Yannan; Jia, Licong; Yang, Guohong; Xu, Xinzhi; Zhai, Hong; He, Shaozhen; Li, Junxia; Dai, Xiaodong; Qin, Na; Zhu, Cancan; Liu, Qingchang

    2018-01-01

    Previously, we obtained the sweetpotato somatic hybrid KT1 from a cross between sweetpotato (Ipomoea batatas (L.) Lam.) cv. Kokei No. 14 and its drought-tolerant wild relative I. triloba L. KT1 not only inherited the thick storage root characteristic of Kokei No. 14 but also the drought-tolerance trait of I. triloba L. The aim of this study was to explore the molecular mechanism of the drought tolerance of KT1. Four-week-old in vitro-grown plants of KT1, Kokei No. 14, and I. triloba L. were subjected to a simulated drought stress treatment (30% PEG6000) for 0, 6, 12 and 24 h. Total RNA was extracted from samples at each time point, and then used for transcriptome sequencing. The gene transcript profiles of KT1 and its parents were compared to identify differentially expressed genes, and drought-related modules were screened by a weighted gene co-expression network analysis. The functions of ABI-like protein and Ca2+-ATPase, two proteins screened from the cyan and light yellow modules, were analyzed in terms of their potential roles in drought tolerance in KT1 and its parents. These analyses of the drought responses of KT1 and its somatic donors at the transcriptional level provide new annotations for the molecular mechanism of drought tolerance in the somatic hybrid KT1 and its parents.

  5. EFFECTS OF AMLODIPIN AND METOPROLOL ON AUTONOMIC SYSTEM IN EMOTIONAL AND COLD TESTS IN HYPERTENSIVE PATIENTS WITH DIFFERENT PSYCHOLOGICAL PROFILE

    Directory of Open Access Journals (Sweden)

    M. P. Rubanova

    2006-01-01

    Full Text Available Aim. To asses effects of amlodipin and metoprolol on autonomic system in emotional and cold tests in hypertensive patients with different psychological profile (PP Material and methods. 61 patients with arterial hypertension of II grade were observed. Therapy with amlodipin or metoprolol was prescribed and allowed to reach target blood pressure (BP level in all the patients. Patients were divided into 2 groups: 1-st one – patients with normal PP, 2-nd group – patients with subclinical depression. Patients were examined before and 30 days after therapy. Examination included ambulatory BP monitoring, assessment of autonomic status by variational intervalometry and spectral analysis of heart rate variability (HRV in cold and emotional tests. Depression and anxiety levels were determined with Bek’s and HADS scales.  Results. Treatment with amlodipin  and metoprolol can result in improvement, worsening or unchanging of PP.  In hypertensive patients with subclinical depression improving their PP resulted in autonomic reaction change: sympathetic activity increases and reaction on stress becomes more adequate. If subclinical depression occurred in hypertensive patients because of amlodipin and metoprolol therapy, sympathetic system stress-reaction decreased and parasympathetic influence increased. Conclusion. The study results show necessity of psychometric examination of hypertensive patients in order to reveal subclinical depression and anxiety.  

  6. Application of the Aero-Hydro-Elastic Model, HAWC2-WAMIT, to Offshore Data from Floating Power Plants Hybrid Wind- and Wave-Energy Test Platform, P37

    DEFF Research Database (Denmark)

    Bellew, Sarah; Yde, Anders; Verelst, David Robert

    2014-01-01

    numerical models, which can combine the aerodynamic, hydrodynamic, structural exibility and mooring components. Very little oshore data exists, however, in order to validate these numerical models. Floating Power Plant are the developers of a oating, hybrid wind- and wave-energy device. The device uses...... the pitching wave energy devices, not only to increase and smooth the power output from the platform, but also to take the energy from the waves in a controlled manner, resulting in a stable platform for the wind turbine and a safe harbour for O&M. They are currently developing the nal design for their rst...... full-scale prototype, the P80, which has a width of 80 m. As part of the development, Floating Power Plant have completed 4 oshore test-phases (totalling over 2 years oshore operation) on a 37 m wide scaled test device, the P37. This paper focuses on the comparison of one of the leading numerical...

  7. Specification of real-time automation systems with HybridUML; Spezifikation von Echtzeit-Automatisierungssystemen mit HybridUML

    Energy Technology Data Exchange (ETDEWEB)

    Berkenkoetter, K.; Bisanz, S.; Hannemann, U.; Peleska, J. [Univ. Bremen (Germany)

    2004-07-01

    Complex automation systems require specification formalisms supporting the description of real-time requirements with respect to both discrete and time-continuous observables. For this purpose, the authors have designed the HybridUML specification language. Discrete events, communication, and variable assignments are specified by state machines, timers, and invariant conditions. The time-continuous aspects of system behaviour are described by associating differential equations or time-dependent algebraic conditions with system states. The complexity of large systems is controlled by decomposing the specification into parallel components and hierarchical state machines. Instead of inventing a new language syntax, HybridUML is represented as a profile of the Unified Modeling Language UML 2.0. This allows to re-use the syntactic framework of well-accepted graphical UML constructs and development support provided by various UML case tools. The profile is associated with a precise language semantics linking unambiguous meaning to all HybridUML specifications. As a consequence, HybridUML specifications can be compiled into executable code which is suitable for execution in hard realtime on multi-processor computers. This serves both for the development of automation systems and for specification-based testing in real-time. This paper contains an introduction to HybridUML which is illustrated by an example from the field of automated train control. (orig.)

  8. PV-hybrid and mini-grid

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2010-07-01

    photovoltaic - fuel cell - direct storage - power supply units; (11) Djungle power - A more remote AC bus; (12) Quality control tools applied to a PV micro-grid in Ecuador; (13) Integral Evaluation of energy supply systems at Mountain Refuges; (14) Hyress project: Study case of Tunisia. Installation, set-up and first results; (15) PV hybrid systems on Mountain Huts: The experience with the project CAI ENERGIA 2000; (16) Process management in zero-emission communities: Adaptation of consumption and production; (17) TRNSYS simulation of a system consisted of PV panels and H{sub 2} production and storage to feed a Remote Telecom Application (HildrosolarH2); (18) Photovoltaic forecasting: A state of the art; (19) PV*SOL 5.0 standalone - Simulation of a stand-alone AC system; (20) Effect of wind speed and solar irradiation on the optimization of a PV wind battery system to supply a Telecommunications station; (21) Polysun: PV, wind and power-heat cogeneration in one design tool; (22) Comparative study between distributed and centralised PV generation in Island power systems under variable weather conditions; (23) Development of a test facility for PV-wind hybrid energy systems; (24) Evaluation of a micro PV-wind hybrid system in Nordic climate conditions; (25) Prismes: The INES micro-grid platform; (26) Estimation of statistical electric energy demand profiles of non electrified regions in Northern Brazil.

  9. Contribution to design and to integrate a flywheel-based storage system in a test bench for electric vehicles with hybrid source; Contribution a la conception et a l'integration d'un accumulateur cinetique d'energie dans une plate-forme de test pour vehicules electriques a source hybride

    Energy Technology Data Exchange (ETDEWEB)

    Briat, O.

    2002-11-01

    This work deals with the design and the integration of a flywheel-based storage system in a test bench for EV with hybrid source. The flywheel used to supply/recover the peak power during acceleration/braking is associated to a battery which supplies the average power. The main goal is to prove the interest of such a sources hybridization for heavy duty EV. First, a simulation tool has been used for EV studies. Models have been validated thanks to on-board vehicle measurements. Then, a EV test bench has been designed on a reduced power scale. The representativeness of this experimental tool has allowed us to validate simulation models. A flywheel module has been integrated and associated to a battery in order to validate the hybridization principle. Experimental results have shown the performances of the battery power limitation and have proved the interest of a systematic regenerative braking on the battery. In these conditions, an increase of the vehicle payload can be expected. (author)

  10. Raman excitation profiles of hybrid systems constituted by single-layer graphene and free base phthalocyanine: Manifestations of two mechanisms of graphene-enhanced Raman scattering

    Czech Academy of Sciences Publication Activity Database

    Uhlířová, T.; Mojzeš, P.; Melníková Komínková, Zuzana; Kalbáč, Martin; Sutrová, Veronika; Šloufová, I.; Vlčková, B.

    2017-01-01

    Roč. 48, č. 10 (2017), s. 1270-1281 ISSN 0377-0486 R&D Projects: GA ČR(CZ) GA15-01953S Institutional support: RVO:61388955 ; RVO:61389013 Keywords : graphene-enhanced Raman scattering * single-layer graphene * free base phthalocyanine * Raman excitation profiles * photoinduced charge transfer Subject RIV: CF - Physical ; Theoretical Chemistry; CD - Macromolecular Chemistry (UMCH-V) OBOR OECD: Physical chemistry; Polymer science (UMCH-V) Impact factor: 2.969, year: 2016

  11. Analysis of instantaneous profile test data from soils near the Mixed Waste Landfill, Technical Area 3, Sandia National Laboratories/New Mexico

    International Nuclear Information System (INIS)

    Goering, T.J.; McVey, M.D.; Strong, W.R.; Peace, J.L.

    1996-02-01

    This paper presents the results of an instantaneous profile test conducted near the Mixed Waste Landfill at Sandia National Laboratories/New Mexico. The purpose of the test was to measure the unsaturated hydraulic properties of soils near the Mixed Waste Landfill, including the relations between hydraulic conductivity, moisture content, and soil water tension. A 4.7 meter by 4.7 meter plot was saturated with water to a depth of 2 meters, and the wetting and drying responses of the vertical profile were observed. These data were analyzed to obtain in situ measurements of the unsaturated hydraulic properties

  12. A Calibrated Test-Set for Measurement of Access-Point Time Specifications in Hybrid Wired/Wireless Industrial Communication †

    Directory of Open Access Journals (Sweden)

    Federico Tramarin

    2018-05-01

    Full Text Available In factory automation and process control systems, hybrid wired/wireless networks are often deployed to connect devices of difficult reachability such as those mounted on mobile equipment. A widespread implementation of these networks makes use of Access Points (APs to implement wireless extensions of Real-Time Ethernet (RTE networks via the IEEE 802.11 Wireless LAN (WLAN. Unfortunately, APs may introduce random delays in frame forwarding, mainly related to their internal behavior (e.g., queue management, processing times, that clearly impact the overall worst case execution time of real-time tasks involved in industrial process control systems. As a consequence, the knowledge of such delays becomes a crucial design parameter, and their estimation is definitely of utter importance. In this scenario, the paper presents an original and effective method to measure the aforementioned delays introduced by APs, exploiting a hybrid loop-back link and a simple, yet accurate set-up with moderate instrumentation requirements. The proposed method, which requires an initial calibration phase by means of a reference AP, has been successfully tested on some commercial APs to prove its effectiveness. The proposed measurement procedure is proven to be general and, as such, can be profitably adopted in even different scenarios.

  13. Assessing child belt fit, volume II : effect of restraint configuration, booster seat designs, seating procedure, and belt fit on the dynamic response of the hybrid III 10-year-old ATD in sled tests.

    Science.gov (United States)

    2008-09-01

    A total of 49 dynamic sled tests were performed with the Hybrid III 10YO to examine issues relating to child belt fit. The goals of these tests were to evaluate ATD response to realistic belt geometries and belt fit, develop methods for accurate, rep...

  14. A mixed methods protocol for developing and testing implementation strategies for evidence-based obesity prevention in childcare: a cluster randomized hybrid type III trial.

    Science.gov (United States)

    Swindle, Taren; Johnson, Susan L; Whiteside-Mansell, Leanne; Curran, Geoffrey M

    2017-07-18

    Despite the potential to reach at-risk children in childcare, there is a significant gap between current practices and evidence-based obesity prevention in this setting. There are few investigations of the impact of implementation strategies on the uptake of evidence-based practices (EBPs) for obesity prevention and nutrition promotion. This study protocol describes a three-phase approach to developing and testing implementation strategies to support uptake of EBPs for obesity prevention practices in childcare (i.e., key components of the WISE intervention). Informed by the i-PARIHS framework, we will use a stakeholder-driven evidence-based quality improvement (EBQI) process to apply information gathered in qualitative interviews on barriers and facilitators to practice to inform the design of implementation strategies. Then, a Hybrid Type III cluster randomized trial will compare a basic implementation strategy (i.e., intervention as usual) with an enhanced implementation strategy informed by stakeholders. All Head Start centers (N = 12) within one agency in an urban area in a southern state in the USA will be randomized to receive the basic or enhanced implementation with approximately 20 classrooms per group (40 educators, 400 children per group). The educators involved in the study, the data collectors, and the biostastician will be blinded to the study condition. The basic and enhanced implementation strategies will be compared on outcomes specified by the RE-AIM model (e.g., Reach to families, Effectiveness of impact on child diet and health indicators, Adoption commitment of agency, Implementation fidelity and acceptability, and Maintenance after 6 months). Principles of formative evaluation will be used throughout the hybrid trial. This study will test a stakeholder-driven approach to improve implementation, fidelity, and maintenance of EBPs for obesity prevention in childcare. Further, this study provides an example of a systematic process to develop

  15. Preliminary data from an instantaneous profile test conducted near the Mixed Waste Landfill, Technical Area 3, Sandia National Laboratories/New Mexico

    International Nuclear Information System (INIS)

    Bayliss, S.C.; Goering, T.J.; McVey, M.D.; Strong, W.R.; Peace, J.L.

    1996-04-01

    This paper presents data from an instantaneous profile test conducted near the Sandia National Laboratories/New Mexico Mixed Waste Landfill in Technical Area 3. The test was performed from December 1993 through 1995 as part of the environmental Restoration Project's Phase 2 RCRA Facility Investigation of the Mixed Waste Landfill. The purpose of the test was to measure the unsaturated hydraulic properties of soils near the Mixed Waste Landfill. The instantaneous profile test and instrumentation are described, and the pressure and moisture content data from the test are presented. These data may be useful for understanding the unsaturated hydraulic properties of soils in Technical Area 3 and for model validation, verification, and calibration

  16. Field Test and Performance Verification: Integrated Active Desiccant Rooftop Hybrid System Installed in a School - Final Report: Phase 4A

    Energy Technology Data Exchange (ETDEWEB)

    Fischer, J

    2005-12-21

    This report summarizes the results of a field verification pilot site investigation that involved the installation of a hybrid integrated active desiccant/vapor-compression rooftop heating, ventilation, and air-conditioning (HVAC) unit at an elementary school in the Atlanta Georgia area. For years, the school had experienced serious humidity and indoor air quality (IAQ) problems that had resulted in occupant complaints and microbial (mold) remediation. The outdoor air louvers of the original HVAC units had been closed in an attempt to improve humidity control within the space. The existing vapor compression variable air volume system was replaced by the integrated active desiccant rooftop (IADR) system that was described in detail in an Oak Ridge National Laboratory (ORNL) report published in 2004 (Fischer and Sand 2004). The IADR system and all space conditions have been monitored remotely for more than a year. The hybrid system was able to maintain both the space temperature and humidity as desired while delivering the outdoor air ventilation rate required by American Society of Heating, Refrigerating and Air-Conditioning Engineers Standard 62. The performance level of the IADR unit and the overall system energy efficiency was measured and found to be very high. A comprehensive IAQ investigation was completed by the Georgia Tech Research Institute before and after the system retrofit. Before-and-after data resulting from this investigation confirmed a significant improvement in IAQ, humidity control, and occupant comfort. These observations were reported by building occupants and are echoed in a letter to ORNL from the school district energy manager. The IADR system was easily retrofitted in place of the original rooftop system using a custom curb adapter. All work was completed in-house by the school's maintenance staff over one weekend. A subsequent cost analysis completed for the school district by the design engineer of record concluded that the IADR

  17. In Vitro and in Vivo Metabolite Profiling of Valnemulin Using Ultraperformance Liquid Chromatography–Quadrupole/Time-of-Flight Hybrid Mass Spectrometry

    Science.gov (United States)

    2015-01-01

    Valnemulin, a semisynthetic pleuromutilin derivative related to tiamulin, is broadly used to treat bacterial diseases of animals. Despite its widespread use, metabolism in animals has not yet been fully investigated. To better understand valnemulin biotransformation, in this study, metabolites of valnemulinin in in vitro and in vivo rats, chickens, swines, goats, and cows were identified and elucidated using ultraperformance liquid chromatography–quadrupole/time-of-flight hybrid mass spectrometry (UPLC-Q/TOF-MS). As a result, there were totally 7 metabolites of valnemulin identified in vitro and 75, 61, and 74 metabolites detected in in vivo rats, chickens, and swines, respectively, and the majority of metabolites were reported for the first time. The main metabolic pathways of valnemulin were found to be hydroxylation in the mutilin part (the ring system) and the side chain, oxidization on the sulfur of the side chain to form S-oxides, hydrolysis of the amido bond, and acetylization in the amido of the side chain. In addition, hydroxylation in the mutilin part was proposed to be the primary metabolic route. Furthermore, the results revealed that 2β-hydroxyvalnemulin (V1) and 8α-hydroxyvalnemulin (V2) were the major metabolites for rats and swines and S-oxides (V6) in chickens. PMID:25156794

  18. Survival of the most transferable at the top of Jacob's ladder: Defining and testing the ωB97M(2) double hybrid density functional

    Science.gov (United States)

    Mardirossian, Narbe; Head-Gordon, Martin

    2018-06-01

    A meta-generalized gradient approximation, range-separated double hybrid (DH) density functional with VV10 non-local correlation is presented. The final 14-parameter functional form is determined by screening trillions of candidate fits through a combination of best subset selection, forward stepwise selection, and random sample consensus (RANSAC) outlier detection. The MGCDB84 database of 4986 data points is employed in this work, containing a training set of 870 data points, a validation set of 2964 data points, and a test set of 1152 data points. Following an xDH approach, orbitals from the ωB97M-V density functional are used to compute the second-order perturbation theory correction. The resulting functional, ωB97M(2), is benchmarked against a variety of leading double hybrid density functionals, including B2PLYP-D3(BJ), B2GPPLYP-D3(BJ), ωB97X-2(TQZ), XYG3, PTPSS-D3(0), XYGJ-OS, DSD-PBEP86-D3(BJ), and DSD-PBEPBE-D3(BJ). Encouragingly, the overall performance of ωB97M(2) on nearly 5000 data points clearly surpasses that of all of the tested density functionals. As a Rung 5 density functional, ωB97M(2) completes our family of combinatorially optimized functionals, complementing B97M-V on Rung 3, and ωB97X-V and ωB97M-V on Rung 4. The results suggest that ωB97M(2) has the potential to serve as a powerful predictive tool for accurate and efficient electronic structure calculations of main-group chemistry.

  19. Monte Carlo simulation of lower hybrid current drive in tokamaks

    International Nuclear Information System (INIS)

    Sipilae, S.K.; Heikkinen, J.A.

    1994-01-01

    In the report a method for noninductive current drive studies based on three-dimensional simulation of test particle orbits is presented. A Monte Carlo momentum diffusion operator is developed to model the wave-particle interaction. The scheme can be utilised in studies of current drive efficiency as well as in examining the current density profiles caused by waves with a finite parallel wave number spectrum and a nonuniform power deposition profile in a toroidal configuration space of arbitrary shape. Calculations performed with a uniform poorer deposition profile of lower hybrid waves for axisymmetric magnetic configurations having different aspect ratios and poloidal cross-section shape confirm the semianalytic estimates for the current drive efficiency based on the solutions of the flux surface averaged Fokker-Planck equation for configurations with circular poloidal cross section. The consequences of the combined effect of radial diffusion, magnetic trapping and radially nonhomogeneous power deposition and background plasma parameter profiles are investigated

  20. Relations Between the Intelligibility of Speech in Noise and Psychophysical Measures of Hearing Measured in Four Languages Using the Auditory Profile Test Battery

    NARCIS (Netherlands)

    van Esch, T. E. M.; Dreschler, W. A.

    2015-01-01

    The aim of the present study was to determine the relations between the intelligibility of speech in noise and measures of auditory resolution, loudness recruitment, and cognitive function. The analyses were based on data published earlier as part of the presentation of the Auditory Profile, a test

  1. Aging investigations of a lithium-ion battery electrolyte from a field-tested hybrid electric vehicle

    Science.gov (United States)

    Grützke, Martin; Kraft, Vadim; Hoffmann, Björn; Klamor, Sebastian; Diekmann, Jan; Kwade, Arno; Winter, Martin; Nowak, Sascha

    2015-01-01

    The electrolyte of a used lithium-ion battery from a hybrid electric vehicle (HEV) was investigated. The liquid electrolyte was collected through the pressure valve of these 5 Ah cells. It consists of (29.8 ± 0.2) wt.% dimethyl carbonate (DMC), (21.7 ± 0.1) wt.% ethyl methyl carbonate (EMC), (30.3 ± 0.3) wt.% ethylene carbonate (EC) and (2.2 ± 0.1) wt.% cyclohexyl benzene (CHB) which were identified with GC-MS and quantified with GC-FID. Li+ (1.29 ± 0.04) mol L-1 and PF6- were determined with IC as the main ionic species in the solution. Furthermore, BF4- was clearly identified with IC-ESI-MS, IC-ICP-MS and 11B NMR and quantified to a concentration of (120.8 ± 8.3) mg L-1 with ICP-OES. The presence of POF3 (detected with GC-MS), F-, PO2F2-, HPO3F- and H2PO4- (determined with IC-ESI-MS) can be attributed to the reaction of the conducting salt LiPF6 via PF5 with traces of water. HPO3F- and H2PO4- could only be observed in cells which were opened in a laboratory hood under exposure of air humidity. This experiment was done to simulate escaping electrolyte from an HEV battery pack. Furthermore, several alkyl phosphates (identified with GC-MS and IC-ESI-MS) are present in the solution due to further reaction of the different fluorinated phosphates with organic carbonates.

  2. [HPV primary test in the cervical cancer screening: reproducibility assessment and investigation on cytological outcome of Hybrid Capture 2 borderline samples].

    Science.gov (United States)

    Burroni, Elena; Sani, Cristina; Bisanzi, Simonetta; Ocello, Cristina

    2016-01-01

    to evaluate the reproducibility of the High-Risk Hybrid Capture 2 (HC2-HR, Qiagen) test within the frame of cervical cancer screening with HPV, for samples with values very close to the cut-off (borderline), that is 0.80≤RLU/CO≤0.99 (RLU/CO: relative light units/cut-off) and to assess any possible presence of high grade lesions. all borderline samples collected from January 2014 to August 2015 were repeated with HR-HC2 test within two weeks from the first test. For HPV-positive samples, cytology and colposcopy results (if present) were analysed. national and international directions recommend the use of HPV testing as a primary test for cervical cancer screening for women aged 30/34-64 years. In Tuscany Region (Central Italy) the primary screening with HPV test was introduced in 2013 and the HPV test currently used, HR-HC2, has a positive cut-off≥1 RLU/CO. proportion of HPV-positive tests at repetition, then stratified by type of material (ThinPrep, STM) and for the following subclasses of RLU/CO: 0.80-0.89 and 0.90-0.99. 253 samples were borderline at first test with HR-HC2 (about 0.4% of all samples tested). About 83% (209/253) of the samples was confirmed to be negative at the HPV test repetition: 88% for RLU/CO=0.80-0.89 and 76% for RLU/CO=0.90-0.99 (p-value=0.014). Median RLU/CO value of 44 HPV-positive samples at repetition is 1.4, with a maximum RLU/CO value of 16.7. In addition, 90% of HPV-positive samples at repetition has a RLU/CO values below or equal to 3.6. Even the used sampling system affects reproducibility: 26.4% (33/125) of the samples resulted positive at the repetition were in ThinPrep vs. 8.6% (11/128) of those in STM (p-valuecut-off (0.90-0.99), confirming the intrinsic limit to all analytical methods near to the cut-off. Moreover, even if the difference in reproducibility between the two systems of sampling is statistically significant, in samples that resulted positive at repetition high-grade lesions were not found at the time of HPV

  3. Genomic profiling of plasmablastic lymphoma using array comparative genomic hybridization (aCGH: revealing significant overlapping genomic lesions with diffuse large B-cell lymphoma

    Directory of Open Access Journals (Sweden)

    Lu Xin-Yan

    2009-11-01

    Full Text Available Abstract Background Plasmablastic lymphoma (PL is a subtype of diffuse large B-cell lymphoma (DLBCL. Studies have suggested that tumors with PL morphology represent a group of neoplasms with clinopathologic characteristics corresponding to different entities including extramedullary plasmablastic tumors associated with plasma cell myeloma (PCM. The goal of the current study was to evaluate the genetic similarities and differences among PL, DLBCL (AIDS-related and non AIDS-related and PCM using array-based comparative genomic hybridization. Results Examination of genomic data in PL revealed that the most frequent segmental gain (> 40% include: 1p36.11-1p36.33, 1p34.1-1p36.13, 1q21.1-1q23.1, 7q11.2-7q11.23, 11q12-11q13.2 and 22q12.2-22q13.3. This correlated with segmental gains occurring in high frequency in DLBCL (AIDS-related and non AIDS-related cases. There were some segmental gains and some segmental loss that occurred in PL but not in the other types of lymphoma suggesting that these foci may contain genes responsible for the differentiation of this lymphoma. Additionally, some segmental gains and some segmental loss occurred only in PL and AIDS associated DLBCL suggesting that these foci may be associated with HIV infection. Furthermore, some segmental gains and some segmental loss occurred only in PL and PCM suggesting that these lesions may be related to plasmacytic differentiation. Conclusion To the best of our knowledge, the current study represents the first genomic exploration of PL. The genomic aberration pattern of PL appears to be more similar to that of DLBCL (AIDS-related or non AIDS-related than to PCM. Our findings suggest that PL may remain best classified as a subtype of DLBCL at least at the genome level.

  4. Potential for bias in using hybrids between common carp (Cyprinus carpio) and goldfish (Carassius auratus) in endocrine studies: a first report of hybrids in Lake Mead, Nevada, U.S.A

    Science.gov (United States)

    Goodbred, Steven L.; Patino, Reynaldo; Orsak, Erik; Sharma, Prakash; Ruessler, Shane

    2013-01-01

    During a 2008 study to assess endocrine and reproductive health of common carp (Cyprinus carpio) in Lake Mead, Nevada (U.S.A.) we identified two fish, one male and one female, as hybrids with goldfish (Carassius auratus) based on morphology, lateral line scale count, and lack of anterior barbels. Gross examination of the female hybrid ovaries indicated presence of vitellogenic ovarian follicles; whereas histological evaluation of the male hybrid testes showed lobule-like structures with open lumens but without germ cells, suggesting it was sterile. Because common carp/goldfish hybrids are more susceptible to gonadal tumors and may have different endocrine profiles than common carp, researchers using common carp as a model for endocrine/reproductive studies should be aware of the possible presence of hybrids.

  5. Comprehensive Genomic Profiling Facilitates Implementation of the National Comprehensive Cancer Network Guidelines for Lung Cancer Biomarker Testing and Identifies Patients Who May Benefit From Enrollment in Mechanism-Driven Clinical Trials.

    Science.gov (United States)

    Suh, James H; Johnson, Adrienne; Albacker, Lee; Wang, Kai; Chmielecki, Juliann; Frampton, Garrett; Gay, Laurie; Elvin, Julia A; Vergilio, Jo-Anne; Ali, Siraj; Miller, Vincent A; Stephens, Philip J; Ross, Jeffrey S

    2016-06-01

    The National Comprehensive Cancer Network (NCCN) guidelines for patients with metastatic non-small cell lung cancer (NSCLC) recommend testing for EGFR, BRAF, ERBB2, and MET mutations; ALK, ROS1, and RET rearrangements; and MET amplification. We investigated the feasibility and utility of comprehensive genomic profiling (CGP), a hybrid capture-based next-generation sequencing (NGS) test, in clinical practice. CGP was performed to a mean coverage depth of 576× on 6,832 consecutive cases of NSCLC (2012-2015). Genomic alterations (GAs) (point mutations, small indels, copy number changes, and rearrangements) involving EGFR, ALK, BRAF, ERBB2, MET, ROS1, RET, and KRAS were recorded. We also evaluated lung adenocarcinoma (AD) cases without GAs, involving these eight genes. The median age of the patients was 64 years (range: 13-88 years) and 53% were female. Among the patients studied, 4,876 (71%) harbored at least one GA involving EGFR (20%), ALK (4.1%), BRAF (5.7%), ERBB2 (6.0%), MET (5.6%), ROS1 (1.5%), RET (2.4%), or KRAS (32%). In the remaining cohort of lung AD without these known drivers, 273 cancer-related genes were altered in at least 0.1% of cases, including STK11 (21%), NF1 (13%), MYC (9.8%), RICTOR (6.4%), PIK3CA (5.4%), CDK4 (4.3%), CCND1 (4.0%), BRCA2 (2.5%), NRAS (2.3%), BRCA1 (1.7%), MAP2K1 (1.2%), HRAS (0.7%), NTRK1 (0.7%), and NTRK3 (0.2%). CGP is practical and facilitates implementation of the NCCN guidelines for NSCLC by enabling simultaneous detection of GAs involving all seven driver oncogenes and KRAS. Furthermore, without additional tissue use or cost, CGP identifies patients with "pan-negative" lung AD who may benefit from enrollment in mechanism-driven clinical trials. National Comprehensive Cancer Network guidelines for patients with metastatic non-small cell lung cancer (NSCLC) recommend testing for several genomic alterations (GAs). The feasibility and utility of comprehensive genomic profiling were studied in NSCLC and in lung adenocarcinoma

  6. Exploiting the full power of temporal gene expression profiling through a new statistical test: Application to the analysis of muscular dystrophy data

    Directory of Open Access Journals (Sweden)

    Turk Rolf

    2006-04-01

    Full Text Available Abstract Background The identification of biologically interesting genes in a temporal expression profiling dataset is challenging and complicated by high levels of experimental noise. Most statistical methods used in the literature do not fully exploit the temporal ordering in the dataset and are not suited to the case where temporal profiles are measured for a number of different biological conditions. We present a statistical test that makes explicit use of the temporal order in the data by fitting polynomial functions to the temporal profile of each gene and for each biological condition. A Hotelling T2-statistic is derived to detect the genes for which the parameters of these polynomials are significantly different from each other. Results We validate the temporal Hotelling T2-test on muscular gene expression data from four mouse strains which were profiled at different ages: dystrophin-, beta-sarcoglycan and gamma-sarcoglycan deficient mice, and wild-type mice. The first three are animal models for different muscular dystrophies. Extensive biological validation shows that the method is capable of finding genes with temporal profiles significantly different across the four strains, as well as identifying potential biomarkers for each form of the disease. The added value of the temporal test compared to an identical test which does not make use of temporal ordering is demonstrated via a simulation study, and through confirmation of the expression profiles from selected genes by quantitative PCR experiments. The proposed method maximises the detection of the biologically interesting genes, whilst minimising false detections. Conclusion The temporal Hotelling T2-test is capable of finding relatively small and robust sets of genes that display different temporal profiles between the conditions of interest. The test is simple, it can be used on gene expression data generated from any experimental design and for any number of conditions, and it

  7. Principal facts of gravity stations with gravity and magnetic profiles from the southwest Nevada Test Site, Nye County, Nevada, as of January 1982

    International Nuclear Information System (INIS)

    Jansma, P.E.; Snyder, D.B.; Ponce, D.A.

    1983-01-01

    Three gravity profiles and principal facts of 2604 gravity stations in the southwest quadrant of the Nevada Test Site are documented in this data report. The residual gravity profiles show the gravity measurements and the smoothed curves derived from these points that were used in geophysical interpretations. The principal facts include station label, latitude, longitude, elevation, observed gravity value, and terrain correction for each station as well as the derived complete Bouguer and isostatic anomalies, reduced at 2.67 g/cm 3 . Accuracy codes, where available, further document the data

  8. Avoiding Pitfalls in Molecular Genetic Testing: Case Studies of High-Resolution Array Comparative Genomic Hybridization Testing in the Definitive Diagnosis of Mowat-Wilson Syndrome

    OpenAIRE

    Kluk, Michael Joseph; An, Yu; James, Philip; Coulter, David; Harris, David; Wu, Bai-Lin; Shen, Yiping

    2011-01-01

    The molecular testing options available for the diagnosis of genetic disorders are numerous and include a variety of different assay platforms. The consultative input of molecular pathologists and cytogeneticists, working closely with the ordering clinicians, is often important for definitive diagnosis. Herein, we describe two patients who had long histories of unexplained signs and symptoms with a high clinical suspicion of an underlying genetic etiology. Initial molecular testing in both ca...

  9. Determination of hoop direction effective elastic moduli of non-circular profile, fiber reinforced polymer composite sewer liner pipes from lateral ring compression tests

    International Nuclear Information System (INIS)

    Czél, Gergely; Takács, Dénes

    2015-01-01

    A new material property determination method is presented for the calculation of effective elastic moduli of non-circular ring specimens cut from filament wound oval profile polymer composite sewer liner pipes. The hoop direction elastic moduli was determined using the test results obtained from ring compression tests, which is a very basic setup, and requires no special equipment. Calculations were executed for many different oval profiles, and diagrams were constructed, from which the cross section dependent C_e_f_f constants can be taken. The new method was validated by the comparison of tests and finite element analysis results. The calculation method and the diagrams are essential design tools for engineers, and a big step forward in sizing non-circular profile liner pipes. - Highlights: • A simple modulus measurement method is presented for non-circular ring specimens. • The evaluation method is validated against a finite element model. • Profile shape dependent constants are presented for a wide range of cross-sections. • A set of charts with the constants are provided to aid design engineers.

  10. Hybrid reactors

    International Nuclear Information System (INIS)

    Moir, R.W.

    1980-01-01

    The rationale for hybrid fusion-fission reactors is the production of fissile fuel for fission reactors. A new class of reactor, the fission-suppressed hybrid promises unusually good safety features as well as the ability to support 25 light-water reactors of the same nuclear power rating, or even more high-conversion-ratio reactors such as the heavy-water type. One 4000-MW nuclear hybrid can produce 7200 kg of 233 U per year. To obtain good economics, injector efficiency times plasma gain (eta/sub i/Q) should be greater than 2, the wall load should be greater than 1 MW.m -2 , and the hybrid should cost less than 6 times the cost of a light-water reactor. Introduction rates for the fission-suppressed hybrid are usually rapid

  11. Rapid profiling of polymeric phenolic acids in Salvia miltiorrhiza by hybrid data-dependent/targeted multistage mass spectrometry acquisition based on expected compounds prediction and fragment ion searching.

    Science.gov (United States)

    Shen, Yao; Feng, Zijin; Yang, Min; Zhou, Zhe; Han, Sumei; Hou, Jinjun; Li, Zhenwei; Wu, Wanying; Guo, De-An

    2018-04-01

    Phenolic acids are the major water-soluble components in Salvia miltiorrhiza (>5%). According to previous studies, many of them contribute to the cardiovascular effects and antioxidant effects of S. miltiorrhiza. Polymeric phenolic acids can be considered as the tanshinol derived metabolites, e.g., dimmers, trimers, and tetramers. A strategy combined with tanshinol-based expected compounds prediction, total ion chromatogram filtering, fragment ion searching, and parent list-based multistage mass spectrometry acquisition by linear trap quadropole-orbitrap Velos mass spectrometry was proposed to rapid profile polymeric phenolic acids in S. miltiorrhiza. More than 480 potential polymeric phenolic acids could be screened out by this strategy. Based on the fragment information obtained by parent list-activated data dependent multistage mass spectrometry acquisition, 190 polymeric phenolic acids were characterized by comparing their mass information with literature data, and 18 of them were firstly detected from S. miltiorrhiza. Seven potential compounds were tentatively characterized as new polymeric phenolic acids from S. miltiorrhiza. This strategy facilitates identification of polymeric phenolic acids in complex matrix with both selectivity and sensitivity, which could be expanded for rapid discovery and identification of compounds from complex matrix. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  12. Non-hydrostatic semi-elastic hybrid-coordinate SISL extension of HIRLAM. Part II: numerical testing

    OpenAIRE

    Rõõm, Rein; Männik, Aarne; Luhamaa, Andres; Zirk, Marko

    2007-01-01

    The semi-implicit semi-Lagrangian (SISL), two-time-level, non-hydrostatic numerical scheme, based on the non-hydrostatic, semi-elastic pressure-coordinate equations, is tested in model experiments with flow over given orography (elliptical hill, mountain ridge, system of successive ridges) in a rectangular domain with emphasis on the numerical accuracy and non-hydrostatic effect presentation capability. Comparison demonstrates good (in strong primary wave generation) to satisfactory (in weak ...

  13. Subpixel mapping and test beam studies with a HV2FEI4v2 CMOS-Sensor-Hybrid Module for the ATLAS inner detector upgrade

    Science.gov (United States)

    Bisanz, T.; Große-Knetter, J.; Quadt, A.; Rieger, J.; Weingarten, J.

    2017-08-01

    The upgrade to the High Luminosity Large Hadron Collider will increase the instantaneous luminosity by more than a factor of 5, thus creating significant challenges to the tracking systems of all experiments. Recent advancement of active pixel detectors designed in CMOS processes provide attractive alternatives to the well-established hybrid design using passive sensors since they allow for smaller pixel sizes and cost effective production. This article presents studies of a high-voltage CMOS active pixel sensor designed for the ATLAS tracker upgrade. The sensor is glued to the read-out chip of the Insertable B-Layer, forming a capacitively coupled pixel detector. The pixel pitch of the device under test is 33× 125 μm2, while the pixels of the read-out chip have a pitch of 50× 250 μm2. Three pixels of the CMOS device are connected to one read-out pixel, the information of which of these subpixels is hit is encoded in the amplitude of the output signal (subpixel encoding). Test beam measurements are presented that demonstrate the usability of this subpixel encoding scheme.

  14. Pain when walking: individual sensory profiles in the foot soles of torture victims - a controlled study using quantitative sensory testing

    Directory of Open Access Journals (Sweden)

    Prip Karen

    2012-12-01

    Full Text Available Abstract Background With quantitative sensory testing (QST we recently found no differences in sensory function of the foot soles between groups of torture victims with or without exposure to falanga (beatings under the feet. Compared to matched controls the torture victims had hyperalgesia to deep mechano-nociceptive stimuli and hypoesthesia to non-noxious cutaneous stimuli. The purpose of the present paper was to extend the group analysis into individual sensory profiles of victims’ feet to explore possible relations between external violence (torture, reported pain, sensory symptoms and QST data to help clarify the underlying mechanisms. Methods We employed interviews and assessments of the pain and sensory symptoms and QST by investigators blinded to whether the patients, 32 male torture victims from the Middle East, had (n=15, or had not (n=17 been exposed to falanga. Pain intensity, area and stimulus dependence were used to characterize the pain. QST included thresholds for touch, cold, warmth, cold-pain, heat-pain, deep pressure pain and wind-up to cutaneous noxious stimuli. An ethnically matched control group was available.The normality criterion, from our control group data, was set as the mean +/− 1.28SD, thus including 80% of all values.QST data were transformed into three categories in relation to our normality range; hypoesthesia, normoesthesia or hyperesthesia/hyperalgesia. Results Most patients, irrespective of having been exposed to falanga or not, reported severe pain when walking. This was often associated with hyperalgesia to deep mechanical pressure. Hypoesthesia to mechanical stimuli co-occurred with numbness, burning and with deep mechanical hyperalgesia more often than not, but otherwise, a hypoesthesia to cutaneous sensory modalities did not co-occur systematically to falanga, pain or sensory symptoms. Conclusion In torture victims, there seem to be overriding mechanisms, manifested by hyperalgesia to pressure pain

  15. Experimental and numerical studies of hybrid PCM embedded in plastering mortar for enhanced thermal behaviour of buildings

    International Nuclear Information System (INIS)

    Kheradmand, Mohammad; Azenha, Miguel; Aguiar, José L.B. de; Castro-Gomes, João

    2016-01-01

    This paper proposes a methodology for improvement of energy efficiency in buildings through the innovative simultaneous incorporation of three distinct phase change materials (here termed as hybrid PCM) in plastering mortars for façade walls. The thermal performance of a hybrid PCM mortar was experimentally evaluated by comparing the behaviour of a prototype test cell (including hybrid PCM plastering mortar) subjected to realistic daily temperature profiles, with the behaviour of a similar prototype test cell, in which no PCM was added. A numerical simulation model was employed (using ANSYS-FLUENT) to validate the capacity of simulating temperature evolution within the prototype containing hybrid PCM, as well as to understand the contribution of hybrid PCM to energy efficiency. Incorporation of hybrid PCM into plastering mortars was found to have the potential to significantly reduce heating/cooling temperature demands for maintaining the interior temperature within comfort levels when compared to normal mortars (without PCM), or even mortars comprising a single type of PCM. - Highlights: • New concept of incorporation of more than 1 type of PCM in plastering mortars (hybrid PCM). • Assessment of thermal performance of hybrid PCM plastering mortar. • Thermo-physical properties of plastering mortars modified with PCMs incorporation. • Experimental and numerical simulations of thermal behaviour on laboratory scale prototype.

  16. 40 CFR 86.129-94 - Road load power, test weight, inertia weight class determination, and fuel temperature profile.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 18 2010-07-01 2010-07-01 false Road load power, test weight, inertia... Procedures § 86.129-94 Road load power, test weight, inertia weight class determination, and fuel temperature... duty trucks 1,2,3 Test weightbasis 4,5 Test equivalent test weight(pounds) Inertia weight class(pounds...

  17. Non-hydrostatic semi-elastic hybrid-coordinate SISL extension of HIRLAM. Part II: numerical testing

    Science.gov (United States)

    Rõõm, Rein; Männik, Aarne; Luhamaa, Andres; Zirk, Marko

    2007-10-01

    The semi-implicit semi-Lagrangian (SISL), two-time-level, non-hydrostatic numerical scheme, based on the non-hydrostatic, semi-elastic pressure-coordinate equations, is tested in model experiments with flow over given orography (elliptical hill, mountain ridge, system of successive ridges) in a rectangular domain with emphasis on the numerical accuracy and non-hydrostatic effect presentation capability. Comparison demonstrates good (in strong primary wave generation) to satisfactory (in weak secondary wave reproduction in some cases) consistency of the numerical modelling results with known stationary linear test solutions. Numerical stability of the developed model is investigated with respect to the reference state choice, modelling dynamics of a stationary front. The horizontally area-mean reference temperature proves to be the optimal stability warrant. The numerical scheme with explicit residual in the vertical forcing term becomes unstable for cross-frontal temperature differences exceeding 30 K. Stability is restored, if the vertical forcing is treated implicitly, which enables to use time steps, comparable with the hydrostatic SISL.

  18. Novel Platinum (Pt)-Vandetanib Hybrid Compounds: Design, Synthesis and Investigation of Anti-cancer Activity and Mechanism of Action

    Science.gov (United States)

    Fei, Rong

    Purpose: Lung cancer is one of the most common cancers and non-small cell lung cancer (NSCLC) accounts for 80-85% of lung cancers. 70% of individuals with NSCLC harboring somatic mutations in exons of the epidermal growth factor receptor (EGFR) gene that encode tyrosine kinase domain. EGFR tyrosine kinase inhibitors (TKIs) are promising molecular targeted therapy for NSCLC with sensitizing EGFR mutations. However, secondary mutation of EGFR after treatment of TKIs develops resistance. Vandetanib is introduced to overcome erlotinib resistance as a multi-targeted TKI. However, its anticancer effect is still compromised by EGFR T790M mutation. Therefore, new molecular anticancer strategies are necessarily needed. In this study, vandetanib is incorporated with Pt-based anticancer agents as hybrid compounds, aiming to circumvent TKI resistance. Furthermore, hybrid compounds are investigated in cisplatin resistant problem to expect to overcome resistance by introduction of vandetanib. Methods: Three novel Pt-vandetanib hybrid compounds were synthesized and its physicochemical properties were characterized. Anticancer activity and cytotoxicity were evaluated by sulforhodamine B assay and lactate dehydrogenase release. Docking simulation was performed to investigate the interaction of compounds with EGFR harboring different mutations. Inhibition efficacy of hybrids to kinases was evaluated by kinase inhibition profiling service and cell-free kinase inhibition assay. Mechanistic studies on cytotoxicity activity of the hybrid compounds were carried out. DNA damage response of hybrid compounds was further investigated in KB cells. The cytotoxicity of hybrids was tested in cisplatin resistant KB CP20 cells. Mechanistic of anticancer activity was studied to test inhibition on oncoprotein CIP2Aand DNA damage. Results: Platinum-vandetanib hybrid compounds were synthesized and test to be stable under extracellular condition. Hybrids reacted with 5'-GMP2- and glutathione, and both

  19. Hybrid composites

    CSIR Research Space (South Africa)

    Jacob John, Maya

    2009-04-01

    Full Text Available mixed short sisal/glass hybrid fibre reinforced low density polyethylene composites was investigated by Kalaprasad et al [25].Chemical surface modifications such as alkali, acetic anhydride, stearic acid, permanganate, maleic anhydride, silane...

  20. Hybrid intermediaries

    OpenAIRE

    Cetorelli, Nicola

    2014-01-01

    I introduce the concept of hybrid intermediaries: financial conglomerates that control a multiplicity of entity types active in the "assembly line" process of modern financial intermediation, a system that has become known as shadow banking. The complex bank holding companies of today are the best example of hybrid intermediaries, but I argue that financial firms from the "nonbank" space can just as easily evolve into conglomerates with similar organizational structure, thus acquiring the cap...

  1. Concordant or discordant results by the tuberculin skin test and the quantiFERON-TB test in children reflect immune biomarker profiles

    DEFF Research Database (Denmark)

    Dhanasekaran, S; Jenum, S; Stavrum, R

    2014-01-01

    The tuberculin skin test (TST) and QuantiFERON-TB-Gold-In-tube (QFTGIT) are adjunctive tests used in the diagnosis of pediatric tuberculosis (TB). Neither test can rule out TB; however, a positive test usually triggers preventive treatment in TB contacts aged <5 years. TST and QFTGIT can give div...

  2. Dissolution comparisons using a Multivariate Statistical Distance (MSD) test and a comparison of various approaches for calculating the measurements of dissolution profile comparison.

    Science.gov (United States)

    Cardot, J-M; Roudier, B; Schütz, H

    2017-07-01

    The f 2 test is generally used for comparing dissolution profiles. In cases of high variability, the f 2 test is not applicable, and the Multivariate Statistical Distance (MSD) test is frequently proposed as an alternative by the FDA and EMA. The guidelines provide only general recommendations. MSD tests can be performed either on raw data with or without time as a variable or on parameters of models. In addition, data can be limited-as in the case of the f 2 test-to dissolutions of up to 85% or to all available data. In the context of the present paper, the recommended calculation included all raw dissolution data up to the first point greater than 85% as a variable-without the various times as parameters. The proposed MSD overcomes several drawbacks found in other methods.

  3. Occupant kinematics of the Hybrid III, THOR-M, and postmortem human surrogates under various restraint conditions in full-scale frontal sled tests.

    Science.gov (United States)

    Albert, Devon L; Beeman, Stephanie M; Kemper, Andrew R

    2018-02-28

    The objective of this research was to compare the occupant kinematics of the Hybrid III (HIII), THOR-M, and postmortem human surrogates (PMHS) during full-scale frontal sled tests under 3 safety restraint conditions: knee bolster (KB), knee bolster and steering wheel airbag (KB/SWAB), and knee bolster airbag and steering wheel airbag (KBAB/SWAB). A total of 20 frontal sled tests were performed with at least 2 tests performed per restraint condition per surrogate. The tests were designed to match the 2012 Toyota Camry New Car Assessment Program (NCAP) full-scale crash test. Rigid polyurethane foam surrogates with compressive strength ratings of 65 and 19 psi were used to simulate the KB and KBAB, respectively. The excursions of the head, shoulders, hips, knees, and ankles were collected using motion capture. Linear acceleration and angular velocity data were also collected from the head, thorax, and pelvis of each surrogate. Time histories were compared between surrogates and restraint conditions using ISO/TS 18571. All surrogates showed some degree of sensitivity to changes in restraint condition. For example, the use of a KBAB decreased the pelvis accelerations and the forward excursions of the knees and hips for all surrogates. However, these trends were not observed for the thorax, shoulders, and head, which showed more sensitivity to the presence of a SWAB. The average scores computed using ISO/TS 18571 for the HIII/PMHS and THOR-M/PMHS comparisons were 0.527 and 0.518, respectively. The HIII had slightly higher scores than the THOR-M for the excursions (HIII average = 0.574; THOR average = 0.520). However, the THOR-M had slightly higher scores for the accelerations and angular rates (HIII average = 0.471; THOR average = 0.516). The data from the current study showed that both KBABs and SWABs affected the kinematics of all surrogates during frontal sled tests. The results of the objective rating analysis indicated that the HIII and THOR-M had comparable

  4. Field Tests on Hydrodynamic and Hybrid Operation of a Bidirectional Thrust Bearing of a Pump-Turbine

    Directory of Open Access Journals (Sweden)

    Michał Wasilczuk

    2017-12-01

    Full Text Available In vertical shaft pump turbines operating in pumped storage power plants an important role is played by a thrust bearing. Due to the bidirectional character of operation, thrust bearing tilting pads have to be supported symmetrically, which is known to be unfavourable from the point of view of their performance. Large thrust bearings have to be carefully designed so as to minimise excessive thermo-elastic pad deformations. The research into fluid film thrust bearings has been quite extensive over the years, comprising theoretical studies of bearing properties with the use of more and more sophisticated calculation codes. On the other hand, the availability of experimental field data on bearing operation is limited, for obvious reasons. In this paper the authors present part of the results of extensive field tests of a large bearing of a pump-turbine they have conducted in a pumped storage power plant. Hopefully this data will be of interest to other researchers to compare theoretical predictions to measurement data.

  5. Analysis of test-beam data with hybrid pixel detector prototypes for the Compact LInear Collider (CLIC) vertex detectors

    CERN Document Server

    Pequegnot, Anne-Laure

    2013-01-01

    The LHC is currently the most powerful accelerator in the world. This proton-proton collider is now stoppped to increase significantly its luminosity and energy, which would provide a larger discovery potential in 2014 and beyond. A high-energy $e^{+}e^{-}$ collider, such as CLIC, is an option to complement and to extend the LHC physics programme. Indeed, a lepton collider gives access to additional physics processes, beyond those observable at the LHC, and therefore provides new discovery potential. It can also provide complementary and/or more precise information about new physics uncovered at the LHC. Many essential features of a detector are required to deliver the full physics potential of this CLIC machine. In this present report, I present my work on the vertex detector R\\&D for this future linear collider, which aims at developping highly granular and ultra-thin position sensitive detection devices with very low power consumption and fast time-stamping capability. We tested here thin silicon pixel...

  6. Design and test of a hybrid foot force sensing and GPS system for richer user mobility activity recognition.

    Science.gov (United States)

    Zhang, Zelun; Poslad, Stefan

    2013-11-01

    Wearable and accompanied sensors and devices are increasingly being used for user activity recognition. However, typical GPS-based and accelerometer-based (ACC) methods face three main challenges: a low recognition accuracy; a coarse recognition capability, i.e., they cannot recognise both human posture (during travelling) and transportation mode simultaneously, and a relatively high computational complexity. Here, a new GPS and Foot-Force (GPS + FF) sensor method is proposed to overcome these challenges that leverages a set of wearable FF sensors in combination with GPS, e.g., in a mobile phone. User mobility activities that can be recognised include both daily user postures and common transportation modes: sitting, standing, walking, cycling, bus passenger, car passenger (including private cars and taxis) and car driver. The novelty of this work is that our approach provides a more comprehensive recognition capability in terms of reliably recognising both human posture and transportation mode simultaneously during travel. In addition, by comparing the new GPS + FF method with both an ACC method (62% accuracy) and a GPS + ACC based method (70% accuracy) as baseline methods, it obtains a higher accuracy (95%) with less computational complexity, when tested on a dataset obtained from ten individuals.

  7. Electric and hybrid vehicles

    Science.gov (United States)

    1979-01-01

    Report characterizes state-of-the-art electric and hybrid (combined electric and heat engine) vehicles. Performance data for representative number of these vehicles were obtained from track and dynamometer tests. User experience information was obtained from fleet operators and individual owners of electric vehicles. Data on performance and physical characteristics of large number of vehicles were obtained from manufacturers and available literature.

  8. Specific Fluorescence in Situ Hybridization (FISH) Test to Highlight Colonization of Xylem Vessels by Xylella fastidiosa in Naturally Infected Olive Trees (Olea europaea L.)

    Science.gov (United States)

    Cardinale, Massimiliano; Luvisi, Andrea; Meyer, Joana B.; Sabella, Erika; De Bellis, Luigi; Cruz, Albert C.; Ampatzidis, Yiannis; Cherubini, Paolo

    2018-01-01

    The colonization behavior of the Xylella fastidiosa strain CoDiRO, the causal agent of olive quick decline syndrome (OQDS), within the xylem of Olea europaea L. is still quite controversial. As previous literature suggests, even if xylem vessel occlusions in naturally infected olive plants were observed, cell aggregation in the formation of occlusions had a minimal role. This observation left some open questions about the whole behavior of the CoDiRO strain and its actual role in OQDS pathogenesis. In order to evaluate the extent of bacterial infection in olive trees and the role of bacterial aggregates in vessel occlusions, we tested a specific fluorescence in situ hybridization (FISH) probe (KO 210) for X. fastidiosa and quantified the level of infection and vessel occlusion in both petioles and branches of naturally infected and non-infected olive trees. All symptomatic petioles showed colonization by X. fastidiosa, especially in the larger innermost vessels. In several cases, the vessels appeared completely occluded by a biofilm containing bacterial cells and extracellular matrix and the frequent colonization of adjacent vessels suggested a horizontal movement of the bacteria. Infected symptomatic trees had 21.6 ± 10.7% of petiole vessels colonized by the pathogen, indicating an irregular distribution in olive tree xylem. Thus, our observations point out the primary role of the pathogen in olive vessel occlusions. Furthermore, our findings indicate that the KO 210 FISH probe is suitable for the specific detection of X. fastidiosa. PMID:29681910

  9. High Efficiency Water Heating Technology Development Final Report. Part I, Lab/Field Performance Evaluation and Accelerated Life Testing of a Hybrid Electric Heat Pump Water Heater (HPWH)

    Energy Technology Data Exchange (ETDEWEB)

    Baxter, Van D. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Murphy, Richard W. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Rice, C. Keith [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Linkous, Randall Lee [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2016-04-01

    DOE has supported efforts for many years with the objective of getting a water heater that uses heat pump technology (aka a heat pump water heater or HPWH) successfully on the residential equipment market. The most recent previous effort (1999-2002) produced a product that performed very well in ORNL-led accelerated durability and field tests. The commercial partner for this effort, Enviromaster International (EMI), introduced the product to the market under the trade name Watter$aver in 2002 but ceased production in 2005 due to low sales. A combination of high sales price and lack of any significant infrastructure for service after the sale were the principal reasons for the failure of this effort. What was needed for market success was a commercial partner with the manufacturing and market distribution capability necessary to allow economies of scale to lead to a viable unit price together with a strong customer service infrastructure. General Electric certainly meets these requirements, and knowing of ORNL s expertise in this area, approached ORNL with the proposal to partner in a CRADA to produce a high efficiency electric water heater. A CRADA with GE was initiated early in Fiscal Year, 2008. GE initially named its product the Hybrid Electric Water Heater (HEWH).

  10. Hybrid method for consistent model of the Pacific absolute plate motion and a test for inter-hotspot motion since 70Ma

    Science.gov (United States)

    Harada, Y.; Wessel, P.; Sterling, A.; Kroenke, L.

    2002-12-01

    Inter-hotspot motion within the Pacific plate is one of the most controversial issues in recent geophysical studies. However, it is a fact that many geophysical and geological data including ages and positions of seamount chains in the Pacific plate can largely be explained by a simple model of absolute motion derived from assumptions of rigid plates and fixed hotspots. Therefore we take the stand that if a model of plate motion can explain the ages and positions of Pacific hotspot tracks, inter-hotspot motion would not be justified. On the other hand, if any discrepancies between the model and observations are found, the inter-hotspot motion may then be estimated from these discrepancies. To make an accurate model of the absolute motion of the Pacific plate, we combined two different approaches: the polygonal finite rotation method (PFRM) by Harada and Hamano (2000) and the hot-spotting technique developed by Wessel and Kroenke (1997). The PFRM can determine accurate positions of finite rotation poles for the Pacific plate if the present positions of hotspots are known. On the other hand, the hot-spotting technique can predict present positions of hotspots if the absolute plate motion is given. Therefore we can undertake iterative calculations using the two methods. This hybrid method enables us to determine accurate finite rotation poles for the Pacific plate solely from geometry of Hawaii, Louisville and Easter(Crough)-Line hotspot tracks from around 70 Ma to present. Information of ages can be independently assigned to the model after the poles and rotation angles are determined. We did not detect any inter-hotspot motion from the geometry of these Pacific hotspot tracks using this method. The Ar-Ar ages of Pacific seamounts including new age data of ODP Leg 197 are used to test the newly determined model of the Pacific plate motion. The ages of Hawaii, Louisville, Easter(Crough)-Line, and Cobb hotspot tracks are quite consistent with each other from 70 Ma to

  11. Evaluation of adjunctive HPV testing by Hybrid Capture II® in women with minor cytological abnormalities for the diagnosis of CIN2/3 and cost comparison with colposcopy

    Directory of Open Access Journals (Sweden)

    Kyi May S

    2003-09-01

    Full Text Available Abstract Background As a proportion of high grade cervical intraepithelial neoplasia (CIN2/3 are associated with equivocal cervical smears, which show borderline or mild dyskaryosis, follow up with repeat smears, colposcopy and biopsy is required. Since infection with oncogenic Human Papilloma Virus (HR HPV has been found to be associated with the development of cervical cancer, HRHPV testing appears to be an alternative. Objective The present study assesses if HRHPV testing can predict CIN2/3 in women referred for mild dyskaryosis and borderline cytological changes in an health authority with a referral policy to colposcopy after one single mild dyskaryotic Pap smear. Study design The HPV DNA Hybrid Capture II (Digene/Abbott, Maidenhead was evaluated on 110 consenting women with mild dyskaryosis and 23 women with persistent borderline changes, who were referred for colposcopy between May and November 2001. A cost comparison between two referral policies was performed. Results CIN2/3 was diagnosed histologically in 30 of 133 women (22% with minor cytological abnormalities. As the Receiver Operator Characteristics plot suggested a cut-off of 3 pg/ml the HRHPV HCII was evaluated at 3 RLU (relative light units and at the manufacturer's recommendation of 1 RLU. At both cut-offs sensitivity and negative predictive value were high at 97%. Specificity was low at 37% at a cut-off of 1 pg/ml and 46% at a cut-off of 3 RLU. To remain cost neutral in comparison to immediate colposcopy the costs for one HR HPV HC II must not exceed £34.37 per test at a cut off of 3 pg/ml. Conclusion The negative likelihood ratio (NLR was of good diagnostic value with 0.089 at 1 RLU and 0.072 at 3 RLU, which reduces the post-test probability for CIN2/3 to 2% in this population. Women with minor cytological disorders can be excluded from colposcopy on a negative HR HPV result. Specificity can be improved by restricting HR HPV testing to women with persistent borderline

  12. MTU hybrid powerpack for railcars

    Energy Technology Data Exchange (ETDEWEB)

    Lehmann, Ingo; Schmalzing, Claus-Oliver [MTU Friedrichshafen GmbH (Germany); Werner, Claus [DB RegioNetz Verkehrs GmbH (Germany); Bold, Uwe [DB Systemtechnik Engineering Kassel (Germany)

    2011-11-15

    Up to 25 percent lower fuel consumption and emission-free train movements in station areas are possible with the MTU hybrid drive system. First field tests on tracks of the Deutsche Bahn started in autumn 2011. (orig.)

  13. Comparison of the clinical performances of the AdvanSure HPV Screening Real-Time PCR, the Abbott Real-Time High-Risk HPV Test, and the Hybrid Capture High-Risk HPV DNA Test for Cervical Cancer Screening.

    Science.gov (United States)

    Chung, Hae-Sun; Hahm, Chorong; Lee, Miae

    2014-09-01

    The clinical performance of three human papillomavirus (HPV) DNA commercial assays for cervical cancer screening was evaluated; the AdvanSure HPV Screening Real-Time PCR (AdvanSure PCR; LG Life Sciences) that was developed recently for the detection of both high-risk and low-risk genotypes, the Abbott RealTime High-Risk HPV Test (Abbott PCR; Abbott Molecular) and the Hybrid Capture High-Risk HPV DNA test (HC2; Qiagen). The three different HPV DNA tests were compared using cytology samples obtained from 619 women who underwent routine cervical cancer screening. The gold-standard assay was histopathological confirmation of cervical intraepithelial neoplasia of grade 2 or worse. The clinical sensitivities of the AdvanSure PCR, the Abbott PCR and the HC2 for the detection of cervical intraepithelial neoplasia of grade 2 or worse were 95.5%, 95.5% and 100%, respectively, while the clinical specificities were 61.6%, 86.4% and 83.3%, respectively. There were no significant differences in the clinical sensitivities of the Abbott PCR and the AdvanSure PCR compared to the HC2. The clinical specificities of the Abbott PCR and the AdvanSure PCR for the detection of HPV types 16/18 were 97.8% and 98.5%, respectively. For cervical cancer screening, all three tests showed relatively good clinical sensitivities, but the AdvanSure PCR had lower clinical specificity than the Abbott PCR and the HC2. The AdvanSure PCR and the Abbott PCR assays have the advantage of being automated and the ability to distinguish between HPV types 16/18 and other HPV types. The two real-time PCR assays could be useful tools in HPV testing for cervical cancer screening. Copyright © 2014 Elsevier B.V. All rights reserved.

  14. ePHM System Development, Hardware-in-the-Loop Testing, Fault Tree, and FMECA Applied to and Integrated on NASA Hybrid Electric Testbeds, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — Hybrid-Electric distributed propulsion (HEDP) is becoming widely accepted and new tools will be required for future development with validation and demonstrations...

  15. Talinum triangulare Whole wheat meal fortified with soy flour consumed with Talinum triangulare (gbure) soup glycemic index and the test human subjects' lipid profiles.

    Science.gov (United States)

    Emaleku, Sunday Adeola; Omueti, Olusola D; Emaleku, Godsent Oluwakemi

    2017-08-24

    Cardiovascular diseases (CVDs) and diabetes mellitus (DM) are some of the leading causes of death in the world, and diet has roles in their etiology. This research study therefore investigates the glycemic index (GI) of soy flour fortified whole wheat meal (SFFWWM) consumed with Talinum triangulare (gbure) soup and the effects of the meal on the lipid profiles of the test human subjects. The control human subjects and test human subjects were fed D-glucose (DG) and whole wheat meal (WWM) with Talinum triangulare soup respectively on the first day of the experiment, and SFFWWM with the same soup the next day (for test subjects only) after 10-12h overnight fasting. Blood glucose levels of the subjects were taken before and 2h after meals' consumption at 30min interval and blood samples collected for lipid profiles evaluations. The result of the study showed that; SFFWWM consumed with Talinum trianguilare soup has a non-significant lower GI than WWM consumed with the same soup, but a significant lower GI than DG at (P<0.05). Furthermore, there was no significant difference in lipid profiles of the test human subjects between when they consumed WWM and SFFWWM with the soup however, SFFWWM reduced TC, TG, LDL-C and VDL-C and increased HDL-C and TP than WMM at (P<0.05). In addition, GI is positively correlated with TC, TG, LDL-C and VLDL-C, but is negatively correlated with TP and HDL-C. It can therefore be concluded that; fortifying WWM with soy flour would reduce the risk factors of CVDs and DM, the diseases recently claiming thousands of today. Copyright © 2017 Diabetes India. Published by Elsevier Ltd. All rights reserved.

  16. Neurocognitive performance and symptom profiles of Spanish-speaking Hispanic athletes on the ImPACT test.

    Science.gov (United States)

    Ott, Summer; Schatz, Philip; Solomon, Gary; Ryan, Joseph J

    2014-03-01

    This study documented baseline neurocognitive performance of 23,815 athletes on the Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT) test. Specifically, 9,733 Hispanic, Spanish-speaking athletes who completed the ImPACT test in English and 2,087 Hispanic, Spanish-speaking athletes who completed the test in Spanish were compared with 11,955 English-speaking athletes who completed the test in English. Athletes were assigned to age groups (13-15, 16-18). Results revealed a significant effect of language group (p Spanish-speaking athletes completing the test in Spanish scored more poorly than Spanish-speaking and English-speaking athletes completing the test in English, on all Composite scores and Total Symptom scores. Spanish-speaking athletes completing the test in English also performed more poorly than English-speaking athletes completing the test in English on three Composite scores. These differences in performance and reported symptoms highlight the need for caution in interpreting ImPACT test data for Hispanic Americans.

  17. Genetic basis to hybrid inviability is more complex than hybrid male sterility in Caenorhabditis nematodes.

    Science.gov (United States)

    Bundus, Joanna D; Wang, Donglin; Cutter, Asher D

    2018-04-07

    Hybrid male sterility often evolves before female sterility or inviability of hybrids, implying that the accumulation of divergence between separated lineages should lead hybrid male sterility to have a more polygenic basis. However, experimental evidence is mixed. Here, we use the nematodes Caenorhabditis remanei and C. latens to characterize the underlying genetic basis of asymmetric hybrid male sterility and hybrid inviability. We demonstrate that hybrid male sterility is consistent with a simple genetic basis, involving a single X-autosome incompatibility. We also show that hybrid inviability involves more genomic compartments, involving diverse nuclear-nuclear incompatibilities, a mito-nuclear incompatibility, and maternal effects. These findings demonstrate that male sensitivity to genetic perturbation may be genetically simple compared to hybrid inviability in Caenorhabditis and motivates tests of generality for the genetic architecture of hybrid incompatibility across the breadth of phylogeny.

  18. Tecnical Note: Analysis of non-regulated vehicular emissions by extractive FTIR spectrometry: tests on a hybrid car in Mexico City

    Science.gov (United States)

    Reyes, F.; Grutter, M.; Jazcilevich, A.; González-Oropeza, R.

    2006-11-01

    A methodology to acquire valuable information on the chemical composition and evolution of vehicular emissions is presented. The analysis of the gases is performed by passing a constant flow of a sample gas from the tail-pipe into a 10 L multi-pass cell. The absorption spectra within the cell are obtained using an FTIR spectrometer at 0.5 cm-1 resolution along a 13.1 m optical path. Additionally, the total flow from the exhaust is continuously measured from a differential pressure sensor on a textit{Pitot} tube installed at the exit of the exhaust. This configuration aims to obtain a good speciation capability by coadding spectra during 30 s and reporting the emission (in g/km) of both criteria and non-regulated pollutants, such as CO2, CO, NO, SO2, NH3, HCHO and some NMHC, during predetermined driving cycles. The advantages and disadvantages of increasing the measurement frequency, as well as the effect of other parameters such as spectral resolution, cell volume and flow rate, are discussed. To test and evaluate the proposed technique, experiments were performed on a dynamometer running FTP-75 and typical driving cycles for the Mexico City Metropolitan Area (MCMA) on a Toyota Prius hybrid vehicle. This car is an example of recent marketed automotive technology dedicated to reduced emissions, increasing the need for sensitive detection techniques. This study shows the potential of the proposed technique to measure and report in real time the emissions of a large variety of pollutants, even from a super ultra-low emission vehicle (SULEV). The emissions of HC's, NOx, CO and CO2 obtained here were compared to experiments performed in other locations with the same model vehicle. The proposed technique provides a tool for future studies comparing in detail the emissions of vehicles using alternative fuels and emission control systems.

  19. Tecnical Note: Analysis of non-regulated vehicular emissions by extractive FTIR spectrometry: tests on a hybrid car in Mexico City

    Directory of Open Access Journals (Sweden)

    F. Reyes

    2006-01-01

    Full Text Available A methodology to acquire valuable information on the chemical composition and evolution of vehicular emissions is presented. The analysis of the gases is performed by passing a constant flow of a sample gas from the tail-pipe into a 10 L multi-pass cell. The absorption spectra within the cell are obtained using an FTIR spectrometer at 0.5 cm−1 resolution along a 13.1 m optical path. Additionally, the total flow from the exhaust is continuously measured from a differential pressure sensor on a extit{Pitot} tube installed at the exit of the exhaust. This configuration aims to obtain a good speciation capability by coadding spectra during 30 s and reporting the emission (in g/km of both criteria and non-regulated pollutants, such as CO2, CO, NO, SO2, NH3, HCHO and some NMHC, during predetermined driving cycles. The advantages and disadvantages of increasing the measurement frequency, as well as the effect of other parameters such as spectral resolution, cell volume and flow rate, are discussed. To test and evaluate the proposed technique, experiments were performed on a dynamometer running FTP-75 and typical driving cycles for the Mexico City Metropolitan Area (MCMA on a Toyota Prius hybrid vehicle. This car is an example of recent marketed automotive technology dedicated to reduced emissions, increasing the need for sensitive detection techniques. This study shows the potential of the proposed technique to measure and report in real time the emissions of a large variety of pollutants, even from a super ultra-low emission vehicle (SULEV. The emissions of HC's, NOx, CO and CO2 obtained here were compared to experiments performed in other locations with the same model vehicle. The proposed technique provides a tool for future studies comparing in detail the emissions of vehicles using alternative fuels and emission control systems.

  20. Stratum corneum profiles of inflammatory mediators in patch test reactions to common contact allergens and sodium lauryl sulfate

    NARCIS (Netherlands)

    Koppes, S. A.; Ljubojevic Hadzavdic, S.; Jakasa, I.; Franceschi, N.; Jurakić Tončić, R.; Marinović, B.; Brans, R.; Gibbs, S.; Frings-Dresen, M. H. W.; Rustemeyer, T.; Kezic, S.

    2017-01-01

    Background Recent studies have demonstrated allergen-specific differences in the gene expression of inflammatory mediators in patch tested skin. Objectives To determine levels of various inflammatory mediators in the stratum corneum (SC) after patch testing with common contact allergens and the skin

  1. Hybrid stars

    Indian Academy of Sciences (India)

    Hybrid stars. AsHOK GOYAL. Department of Physics and Astrophysics, University of Delhi, Delhi 110 007, India. Abstract. Recently there have been important developments in the determination of neutron ... number and the electric charge. ... available to the system to rearrange concentration of charges for a given fraction of.

  2. Relations Between the Intelligibility of Speech in Noise and Psychophysical Measures of Hearing Measured in Four Languages Using the Auditory Profile Test Battery

    Directory of Open Access Journals (Sweden)

    T. E. M. Van Esch

    2015-12-01

    Full Text Available The aim of the present study was to determine the relations between the intelligibility of speech in noise and measures of auditory resolution, loudness recruitment, and cognitive function. The analyses were based on data published earlier as part of the presentation of the Auditory Profile, a test battery implemented in four languages. Tests of the intelligibility of speech, resolution, loudness recruitment, and lexical decision making were measured using headphones in five centers: in Germany, the Netherlands, Sweden, and the United Kingdom. Correlations and stepwise linear regression models were calculated. In sum, 72 hearing-impaired listeners aged 22 to 91 years with a broad range of hearing losses were included in the study. Several significant correlations were found with the intelligibility of speech in noise. Stepwise linear regression analyses showed that pure-tone average, age, spectral and temporal resolution, and loudness recruitment were significant predictors of the intelligibility of speech in fluctuating noise. Complex interrelationships between auditory factors and the intelligibility of speech in noise were revealed using the Auditory Profile data set in four languages. After taking into account the effects of pure-tone average and age, spectral and temporal resolution and loudness recruitment had an added value in the prediction of variation among listeners with respect to the intelligibility of speech in noise. The results of the lexical decision making test were not related to the intelligibility of speech in noise, in the population studied.

  3. A neutron powder diffraction study of deuterated α-resorcinol: a test of profile refinement using TLS constraints

    International Nuclear Information System (INIS)

    Bacon, G.E.; Lisher, E.J.

    1979-01-01

    Constrained TL, TLX and TLS refinements have been used, with the powder-profile method, in the analysis of accurate neutron powder data for deuterated α-resorcinol at room temperature. There is good agreement between the translational and librational parameters derived from the TL refinement and those obtained from an equivalent analysis of accurate single-crystal neutron measurements. The fine details of the benzene ring are lost in the powder analysis, but the molecular orientation and the OH bond angles are in good agreement with the single-crystal values. No significant improvement could be found in the powder fit by applying the full TLS theory and, therefore, the approximate TLX model appears to be adequate for powder data. (Auth.)

  4. Quantitative sensory testing somatosensory profiles in patients with cervical radiculopathy are distinct from those in patients with nonspecific neck-arm pain.

    Science.gov (United States)

    Tampin, Brigitte; Slater, Helen; Hall, Toby; Lee, Gabriel; Briffa, Noelle Kathryn

    2012-12-01

    The aim of this study was to establish the somatosensory profiles of patients with cervical radiculopathy and patients with nonspecific neck-arm pain associated with heightened nerve mechanosensitivity (NSNAP). Sensory profiles were compared to healthy control (HC) subjects and a positive control group comprising patients with fibromyalgia (FM). Quantitative sensory testing (QST) of thermal and mechanical detection and pain thresholds, pain sensitivity and responsiveness to repetitive noxious mechanical stimulation was performed in the maximal pain area, the corresponding dermatome and foot of 23 patients with painful C6 or C7 cervical radiculopathy, 8 patients with NSNAP in a C6/7 dermatomal pain distribution, 31 HC and 22 patients with FM. For both neck-arm pain groups, all QST parameters were within the 95% confidence interval of HC data. Patients with cervical radiculopathy were characterised by localised loss of function (thermal, mechanical, vibration detection Ppain area and dermatome (thermal detection, vibration detection, pressure pain sensitivity Ppain groups demonstrated increased cold sensitivity in their maximal pain area (Ppain groups differed from patients with FM, the latter characterised by a widespread gain of function in most nociceptive parameters (thermal, pressure, mechanical pain sensitivity Ppain characteristics between the 2 neck-arm pain groups, distinct sensory profiles were demonstrated for each group. Copyright © 2012 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.

  5. Tetraoxane-pyrimidine nitrile hybrids as dual stage antimalarials.

    Science.gov (United States)

    Oliveira, Rudi; Guedes, Rita C; Meireles, Patrícia; Albuquerque, Inês S; Gonçalves, Lídia M; Pires, Elisabete; Bronze, Maria Rosário; Gut, Jiri; Rosenthal, Philip J; Prudêncio, Miguel; Moreira, Rui; O'Neill, Paul M; Lopes, Francisca

    2014-06-12

    The use of artemisinin or other endoperoxides in combination with other drugs is a strategy to prevent development of resistant strains of Plasmodium parasites. Our previous work demonstrated that hybrid compounds, comprising endoperoxides and vinyl sulfones, were capable of high activity profiles comparable to artemisinin and chloroquine while acting through two distinct mechanisms of action: oxidative stress and falcipain inhibition. In this study, we adapted this approach to a novel class of falcipain inhibitors: peptidomimetic pyrimidine nitriles. Pyrimidine tetraoxane hybrids displayed potent nanomolar activity against three strains of Plasmodium falciparum and falcipain-2, combined with low cytotoxicity. In vivo, a decrease in parasitemia and an increase in survival of mice infected with Plasmodium berghei was observed when compared to control. All tested compounds combined good blood stage activity with significant effects on liver stage parasitemia, a most welcome feature for any new class of antimalarial drug.

  6. Amino Acid and Biogenic Amine Profile Deviations in an Oral Glucose Tolerance Test: A Comparison between Healthy and Hyperlipidaemia Individuals Based on Targeted Metabolomics

    Directory of Open Access Journals (Sweden)

    Qi Li

    2016-06-01

    Full Text Available Hyperlipidemia (HLP is characterized by a disturbance in lipid metabolism and is a primary risk factor for the development of insulin resistance (IR and a well-established risk factor for cardiovascular disease and atherosclerosis. The aim of this work was to investigate the changes in postprandial amino acid and biogenic amine profiles provoked by an oral glucose tolerance test (OGTT in HLP patients using targeted metabolomics. We used ultra-high-performance liquid chromatography-triple quadrupole mass spectrometry to analyze the serum amino acid and biogenic amine profiles of 35 control and 35 HLP subjects during an OGTT. The amino acid and biogenic amine profiles from 30 HLP subjects were detected as independent samples to validate the changes in the metabolites. There were differences in the amino acid and biogenic amine profiles between the HLP individuals and the healthy controls at baseline and after the OGTT. The per cent changes of 13 metabolites from fasting to the 2 h samples during the OGTT in the HLP patients were significantly different from those of the healthy controls. The lipid parameters were associated with the changes in valine, isoleucine, creatine, creatinine, dimethylglycine, asparagine, serine, and tyrosine (all p < 0.05 during the OGTT in the HLP group. The postprandial changes in isoleucine and γ-aminobutyric acid (GABA during the OGTT were positively associated with the homeostasis model assessment of insulin resistance (HOMA-IR; all p < 0.05 in the HLP group. Elevated oxidative stress and disordered energy metabolism during OGTTs are important characteristics of metabolic perturbations in HLP. Our findings offer new insights into the complex physiological regulation of metabolism during the OGTT in HLP.

  7. Combustion Performance of a Staged Hybrid Rocket with Boron addition

    Science.gov (United States)

    Lee, D.; Lee, C.

    2018-04-01

    In this paper, the effect of boron on overall system specific impulse was investigated. Additionally, a series of combustion tests was carried out to analyze and evaluate the effect of boron addition on O/F variation and radial temperature profiles. To maintain the hybrid rocket engine advantages, upper limit of boron contents in solid fuel was set to be 10 wt%. The results also suggested that, when adding boron to solid fuel, it helped to provide more uniform radial temperature distribution and also to increase specific impulse by 3.2%.

  8. Understanding the formation and influence of attitudes in patients' treatment choices for lower back pain: Testing the benefits of a hybrid choice model approach

    DEFF Research Database (Denmark)

    Kløjgaard, Mirja Elisabeth; Hess, S.

    2014-01-01

    A growing number of studies across different fields are making use of a new class of choice models, labelled variably as hybrid model structures or integrated choice and latent variable models, and incorporating the role of attitudes in decision making. To date, this technique has not been used...... in spring/summer 2012. We show how the hybrid model structure is able to make a link between attitudinal questions and treatment choices, and also explains variation of these attitudes across key socio-demographic groups. However, we also show how, in this case, only a small share of the overall...

  9. Profile of an HIV Testing and Counseling Unit in Bangladesh: Majority of New Diagnoses among Returning Migrant Workers and Spouses.

    Directory of Open Access Journals (Sweden)

    Arunthia Zaidi Urmi

    Full Text Available Analysis of data from HIV testing and counseling (HTC services provides an opportunity to identify important populations for targeting of HIV prevention efforts. Our primary aim was to describe the demographics of clients presenting to HTC in Bangladesh, a low HIV prevalence country. Our secondary aim was to determine the risk factors for HIV positivity among returning migrant workers who were tested.We performed a cross-sectional study of data collected between 2002 and 2010 from the first HTC service established in Bangladesh, located in three large cities.8973 individuals attended HTC services, with 558 (6.2% of clients testing positive for HIV, including 33 children. The majority of those who tested positive were aged 25-44 (71%, male (70%, and married (68%. Key populations considered at increased risk of HIV, such as female sex workers, people who inject drugs, and males who have sex with males accounted for only 11% of adults who tested positive. Notably, 75% of adults testing positive had a history of migrant work or was the spouse of a migrant worker. In multivariable logistic regression of those with a migrant work history presenting for HTC, we found rural residence, working in the Middle East, and longer duration of migrant work to be independently associated with testing positive, and female gender and higher level of education to be negatively associated.These data suggest that in Bangladesh, in addition to targeting traditional key populations, HIV prevention efforts should also focus on migrant workers and their spouses.

  10. Chromogenic In Situ Hybridization and p16/Ki67 Dual Staining on Formalin-Fixed Paraffin-Embedded Cervical Specimens: Correlation with HPV-DNA Test, E6/E7 mRNA Test, and Potential Clinical Applications

    Directory of Open Access Journals (Sweden)

    Roberta Zappacosta

    2013-01-01

    Full Text Available Although HPV-DNA test and E6/E7 mRNA analyses remain the current standard for the confirmation of human papillomavirus (HPV infections in cytological specimens, no universally adopted techniques exist for the detection of HPV in formalin-fixed paraffin-embedded samples. Particularly, in routine laboratories, molecular assays are still time-consuming and would require a high level of expertise. In this study, we investigated the possible use of a novel HPV tyramide-based chromogenic in situ hybridization (CISH technology to locate HPV on tissue specimens. Then, we evaluate the potential usefulness of p16INK4a/Ki-67 double stain on histological samples, to identify cervical cells expressing HPV E6/E7 oncogenes. In our series, CISH showed a clear signal in 95.2% of the specimens and reached a sensitivity of 86.5%. CISH positivity always matched with HPV-DNA positivity, while 100% of cases with punctated signal joined with cervical intraepithelial neoplasia grade 2 or worse (CIN2+. p16/Ki67 immunohistochemistry gave an interpretable result in 100% of the cases. The use of dual stain significantly increased the agreement between pathologists, which reached 100%. Concordance between dual stain and E6/E7 mRNA test was 89%. In our series, both CISH and p16INK4a/Ki67 dual stain demonstrated high grade of performances. In particular, CISH would help to distinguish episomal from integrated HPV, in order to allow conclusions regarding the prognosis of the lesion, while p16INK4a/Ki67 dual stain approach would confer a high level of standardization to the diagnostic procedure.

  11. Chromogenic In Situ Hybridization and p16/Ki67 Dual Staining on Formalin-Fixed Paraffin-Embedded Cervical Specimens: Correlation with HPV-DNA Test, E6/E7 mRNA Test, and Potential Clinical Applications

    Science.gov (United States)

    Zappacosta, Roberta; Colasante, Antonella; Viola, Patrizia; D'Antuono, Tommaso; Lattanzio, Giuseppe; Capanna, Serena; Gatta, Daniela Maria Pia; Rosini, Sandra

    2013-01-01

    Although HPV-DNA test and E6/E7 mRNA analyses remain the current standard for the confirmation of human papillomavirus (HPV) infections in cytological specimens, no universally adopted techniques exist for the detection of HPV in formalin-fixed paraffin-embedded samples. Particularly, in routine laboratories, molecular assays are still time-consuming and would require a high level of expertise. In this study, we investigated the possible use of a novel HPV tyramide-based chromogenic in situ hybridization (CISH) technology to locate HPV on tissue specimens. Then, we evaluate the potential usefulness of p16INK4a/Ki-67 double stain on histological samples, to identify cervical cells expressing HPV E6/E7 oncogenes. In our series, CISH showed a clear signal in 95.2% of the specimens and reached a sensitivity of 86.5%. CISH positivity always matched with HPV-DNA positivity, while 100% of cases with punctated signal joined with cervical intraepithelial neoplasia grade 2 or worse (CIN2+). p16/Ki67 immunohistochemistry gave an interpretable result in 100% of the cases. The use of dual stain significantly increased the agreement between pathologists, which reached 100%. Concordance between dual stain and E6/E7 mRNA test was 89%. In our series, both CISH and p16INK4a/Ki67 dual stain demonstrated high grade of performances. In particular, CISH would help to distinguish episomal from integrated HPV, in order to allow conclusions regarding the prognosis of the lesion, while p16INK4a/Ki67 dual stain approach would confer a high level of standardization to the diagnostic procedure. PMID:24369532

  12. Identificação de híbridos de citros resistentes à mancha-marrom-de-alternária por meio de fAFLP e testes de patogenicidade Alternaria brown spot resistant citrus hybrid identification by means of fAFLP and pathogenicity tests

    Directory of Open Access Journals (Sweden)

    Edvan Alves Chagas

    2007-07-01

    Full Text Available O objetivo deste trabalho foi identificar híbridos, oriundos de hibridações controladas entre 'Folha Murcha' x 'Ponkan' e testá-los quanto à resistência a Alternaria alternata f. sp. citri. As plântulas foram obtidas via cultura in vitro de embriões. Utilizou-se o marcador molecular fAFLP para identificação dos híbridos e, em seguida, realizou-se o teste de patogenicidade nos híbridos com isolados de Alternaria alternata f. sp. citri, em condições de laboratório. Os pares de primers EcoRI AAG - MseI CAG e EcoRI ACC - MseI CAA foram os mais eficientes na identificação dos híbridos, os quais identificaram 48,5% de híbridos. Os híbridos F64, F108, F111, F113, F131 e F139 são potencialmente resistentes a Alternaria alternata f. sp. citri.The objective of this work was to identify hybrids obtained from controlled crossings between 'Folha Murcha' x 'Ponkan', and to check their resistance to Alternaria alternata f. sp. citri. The seedlings were obtained by in vitro embryo culture. The fAFLP marker technique was used to identify the hybrids, then laboratory pathogenicity test of the hybrids was accomplished with Alternaria alternata f. sp. citri isolates. The pairs of primers EcoRI AAG - Msel CAG and EcoRI ACC - Msel CAA were the most efficient for hybrids identification, and distinguished 48.5% of hybrids. Hybrids F64, F108, F111, F113, F131 and F139 showed potential resistance to the Alternaria alternata f. sp. citri.

  13. Performance Study of Monte Carlo Codes on Xeon Phi Coprocessors — Testing MCNP 6.1 and Profiling ARCHER Geometry Module on the FS7ONNi Problem

    Science.gov (United States)

    Liu, Tianyu; Wolfe, Noah; Lin, Hui; Zieb, Kris; Ji, Wei; Caracappa, Peter; Carothers, Christopher; Xu, X. George

    2017-09-01

    This paper contains two parts revolving around Monte Carlo transport simulation on Intel Many Integrated Core coprocessors (MIC, also known as Xeon Phi). (1) MCNP 6.1 was recompiled into multithreading (OpenMP) and multiprocessing (MPI) forms respectively without modification to the source code. The new codes were tested on a 60-core 5110P MIC. The test case was FS7ONNi, a radiation shielding problem used in MCNP's verification and validation suite. It was observed that both codes became slower on the MIC than on a 6-core X5650 CPU, by a factor of 4 for the MPI code and, abnormally, 20 for the OpenMP code, and both exhibited limited capability of strong scaling. (2) We have recently added a Constructive Solid Geometry (CSG) module to our ARCHER code to provide better support for geometry modelling in radiation shielding simulation. The functions of this module are frequently called in the particle random walk process. To identify the performance bottleneck we developed a CSG proxy application and profiled the code using the geometry data from FS7ONNi. The profiling data showed that the code was primarily memory latency bound on the MIC. This study suggests that despite low initial porting e_ort, Monte Carlo codes do not naturally lend themselves to the MIC platform — just like to the GPUs, and that the memory latency problem needs to be addressed in order to achieve decent performance gain.

  14. Clinical Performance and Management Outcomes with the DecisionDx-UM Gene Expression Profile Test in a Prospective Multicenter Study

    Directory of Open Access Journals (Sweden)

    Kristen Meldi Plasseraud

    2016-01-01

    Full Text Available Uveal melanoma management is challenging due to its metastatic propensity. DecisionDx-UM is a prospectively validated molecular test that interrogates primary tumor biology to provide objective information about metastatic potential that can be used in determining appropriate patient care. To evaluate the continued clinical validity and utility of DecisionDx-UM, beginning March 2010, 70 patients were enrolled in a prospective, multicenter, IRB-approved study to document patient management differences and clinical outcomes associated with low-risk Class 1 and high-risk Class 2 results indicated by DecisionDx-UM testing. Thirty-seven patients in the prospective study were Class 1 and 33 were Class 2. Class 1 patients had 100% 3-year metastasis-free survival compared to 63% for Class 2 (log rank test p=0.003 with 27.3 median follow-up months in this interim analysis. Class 2 patients received significantly higher-intensity monitoring and more oncology/clinical trial referrals compared to Class 1 patients (Fisher’s exact test p=2.1×10-13 and p=0.04, resp.. The results of this study provide additional, prospective evidence in an independent cohort of patients that Class 1 and Class 2 patients are managed according to the differential metastatic risk indicated by DecisionDx-UM. The trial is registered with Clinical Application of DecisionDx-UM Gene Expression Assay Results (NCT02376920.

  15. Pain when walking: individual sensory profiles in the foot soles of torture victims - a controlled study using quantitative sensory testing

    DEFF Research Database (Denmark)

    Prip, K.; Persson, A. L.; Sjolund, B. H.

    2012-01-01

    Background: With quantitative sensory testing (QST) we recently found no differences in sensory function of the foot soles between groups of torture victims with or without exposure to falanga (beatings under the feet). Compared to matched controls the torture victims had hyperalgesia to deep mec...

  16. Building a Robust Tumor Profiling Program: Synergy between Next-Generation Sequencing and Targeted Single-Gene Testing.

    Directory of Open Access Journals (Sweden)

    Matthew C Hiemenz

    Full Text Available Next-generation sequencing (NGS is a powerful platform for identifying cancer mutations. Routine clinical adoption of NGS requires optimized quality control metrics to ensure accurate results. To assess the robustness of our clinical NGS pipeline, we analyzed the results of 304 solid tumor and hematologic malignancy specimens tested simultaneously by NGS and one or more targeted single-gene tests (EGFR, KRAS, BRAF, NPM1, FLT3, and JAK2. For samples that passed our validated tumor percentage and DNA quality and quantity thresholds, there was perfect concordance between NGS and targeted single-gene tests with the exception of two FLT3 internal tandem duplications that fell below the stringent pre-established reporting threshold but were readily detected by manual inspection. In addition, NGS identified clinically significant mutations not covered by single-gene tests. These findings confirm NGS as a reliable platform for routine clinical use when appropriate quality control metrics, such as tumor percentage and DNA quality cutoffs, are in place. Based on our findings, we suggest a simple workflow that should facilitate adoption of clinical oncologic NGS services at other institutions.

  17. The Impact of Emotions on Student Achievement in Synchronous Hybrid Business and Public Administration Programs: A Longitudinal Test of Control-Value Theory

    Science.gov (United States)

    Butz, Nikolaus T.; Stupnisky, Robert H.; Pekrun, Reinhard; Jensen, Jason L.; Harsell, Dana M.

    2016-01-01

    Synchronous hybrid delivery (simultaneously teaching on-campus and online students using Web conferencing) is becoming more common in higher education. However, little is known about students' emotions in these environments. Although often overlooked, emotions are fundamental antecedents of success. This study longitudinally examined the role of…

  18. Removal of the lower hybrid (LH) frequency time scale in test electron simulations of LH-induced tokamak edge electron flow

    Czech Academy of Sciences Publication Activity Database

    Fuchs, Vladimír; Petržílka, Václav; Gunn, J. P.; Goniche, M.

    2002-01-01

    Roč. 52, supplement D (2002), s. 45-50 ISSN 0011-4626. [Symposium on Plasma Physics and Technology/20th./. Prague, 10.06.2002-13.06.2002] Institutional research plan: CEZ:AV0Z2043910 Keywords : tokamak, edge electrons, lower hybrid antenna Subject RIV: BL - Plasma and Gas Discharge Physics Impact factor: 0.311, year: 2002

  19. A cluster randomized Hybrid Type III trial testing an implementation support strategy to facilitate the use of an evidence-based practice in VA homeless programs.

    Science.gov (United States)

    Smelson, David A; Chinman, Matthew; McCarthy, Sharon; Hannah, Gordon; Sawh, Leon; Glickman, Mark

    2015-05-28

    The Housing and Urban Development-Veterans Affairs Supportive Housing (HUD-VASH) program is one of the largest initiatives to end Veteran homelessness. However, mental health and substance use disorders continue to reduce client stability and impede program success. HUD-VASH programs do not consistently employ evidence-based practices that address co-occurring mental health and substance use disorders. This paper presents a study protocol to evaluate the implementation of an evidence-based, co-occurring disorder treatment called Maintaining Independence and Sobriety Through Systems Integration, Outreach, and Networking-Veterans Edition (MISSION-Vet) in HUD-VASH using an implementation strategy called Getting To Outcomes (GTO). In three large VA Medical Centers, this Hybrid Type III trial will randomize case managers and their clients by HUD-VASH sub-teams to receive either MISSION-Vet Implementation as Usual (IU-standard training and access to the MISSION-Vet treatment manuals) or MISSION-Vet implementation augmented by GTO. In addition to testing GTO, effectiveness of the treatment (MISSION-Vet) will be assessed using existing Veteran-level data from the HUD-VASH data monitoring system. This project will compare GTO and IU case managers and their clients on the following variables: (1) fidelity to the MISSION-Vet intervention; (2) proportion of time the Veteran is housed; (3) mental health, substance use, and functional outcomes among Veterans; and (4) factors key to the successful deployment of a new treatment as specified by the Reach, Effectiveness, Adoption, Implementation, and Maintenance (RE-AIM) model. This project is an important step for developing an implementation strategy to increase adoption of evidence-based practice use in VA homeless programs, and to further examine efficacy of MISSION-Vet in HUD-VASH. This project has important implications for program managers, policy makers, and researchers within the homelessness field. VA Central IRB approval

  20. Design and performance test of CPC-PV/TE hybrid power generation system in greenhouse.%温室聚光光伏/温差联合发电系统的设计与性能试验

    Institute of Scientific and Technical Information of China (English)

    王立舒; 李琳; 梁秋艳; 丁修增; 王博林

    2015-01-01

    With the rapid development of agricultural science and technology, various types of environmental testing equipments and production facilities consume a lot of energy in greenhouse. Therefore, it is important to design a high-efficiency greenhouse power supply device. At the same time, the energy crisis in the 21st century and the air pollution caused by burning of fossil fuels become serious. It can not wait to solve the environmental pollution. Therefore, increasing the development and utilization of solar energy is imminent. Solar energy is a kind of clean and renewable energy, and the study of solar energy development and utilization has become a hot issue nowadays, but in general, its efficiency is low. In order to solve the problem of large fossil energy consumption in the greenhouse and the current inefficient use of solar energy, compound parabolic concentrator-photovoltaic / thermoelectric hybrid power generation system (CPC-PV/TE) based on the characteristics of greenhouse in Northeast China is proposed in the present paper. A system contains CPC, PV/TE hybrid system and flat heat pipe. CPC converges light to the surface of photovoltaic cells. It enhances light irradiation intensity. Photovoltaic cells use the photovoltaic effect principle to generate electricity. Attached to photovoltaic cells, thermoelectric power generator modules convert the excess heat generated by photovoltaic cells power generation to electricity power simultaneously. Flat heat pipe is used as heat transfer element, and then a certain amount of water is used to effectively transfer the rest of the heat. In order to express the performance of CPC-PV/TE hybrid power generation system accurately, a comprehensive energy transfer model has been established, and the efficiency of CPC-PV/TE hybrid system and PV or TE module alone under different levels of irradiation and various water flows has been discussed. The results show that the faster the cooling water flows, the higher the

  1. Behavioural profiles in the mouse defence test battery suggest anxiolytic potential of 5-HT(1A) receptor antagonists.

    Science.gov (United States)

    Griebel, G; Rodgers, R J; Perrault, G; Sanger, D J

    1999-05-01

    Compounds varying in selectivity as 5-HT1A receptor antagonists have recently been reported to produce anxiolytic-like effects comparable to those of benzodiazepines in the mouse elevated plus-maze procedure. In view of the potential clinical significance of these findings, the present experiments compared the behavioural effects of diazepam (0.5-3.0 mg/kg) with those of several non-selective 5-HT1A receptor antagonists [NAN-190, 0.1-3.0 mg/kg, MM-77, 0.03-1.0 mg/kg, (S)-UH-301, 0.3-3.0 mg/kg and pindobind-5-HT1A, 0.03-1.0 mg/kg], and three selective 5-HT1A receptor antagonists (WAY100635, 0.01-3.0 mg/kg, p-MPPI, 0.1-3.0 mg/kg and SL88.0338, 0.3-3.0 mg/kg) in the mouse defence test battery (MDTB). In this well-validated anxiolytic screening test, Swiss mice are directly confronted with a natural threat (a rat) as well as situations associated with this threat. Primary measures taken during and after rat confrontation were flight, risk assessment (RA), defensive threat/attack and escape attempts. Diazepam significantly decreased flight reactions after the rat was introduced into the runway, reduced RA activities of mice chased by the rat, increased RA responses displayed when subjects were constrained in a straight alley and reduced defensive upright postures and biting upon forced contact. All the selective 5-HT1A receptor antagonists and NAN-190 also reduced flight, RA in the chase test, and defensive threat and attack behaviours. (S)-UH-301 and pindobind-5-HT1A reduced RA in the chase test, but only partially modified defensive threat and attack. Unlike the other drugs tested, MM-77 produced significant effects only at doses which also markedly reduced spontaneous locomotor activity, suggesting a behaviourally non-specific action. In contrast to diazepam, the 5-HT1A receptor ligands failed to affect RA in the straight alley test. Following removal of the rat from the test area, only diazepam and (S)-UH-301 reduced escape behaviour (contextual defence) at doses

  2. Active and Passive Hybrid Sensor

    Science.gov (United States)

    Carswell, James R.

    2010-01-01

    A hybrid ocean wind sensor (HOWS) can map ocean vector wind in low to hurricane-level winds, and non-precipitating and precipitating conditions. It can acquire active and passive measurements through a single aperture at two wavelengths, two polarizations, and multiple incidence angles. Its low profile, compact geometry, and low power consumption permits installation on air craft platforms, including high-altitude unmanned aerial vehicles (UAVs).

  3. The Curious Case of the "Refrigerator-TV": Similarity and Hybridization

    Science.gov (United States)

    Gibbert, Michael; Hampton, James A.; Estes, Zachary; Mazursky, David

    2012-01-01

    This article examines the role of similarity in the hybridization of concepts, focusing on hybrid products as an applied test case. Hybrid concepts found in natural language, such as "singer songwriter," typically combine similar concepts, whereas dissimilar concepts rarely form hybrids. The hybridization of dissimilar concepts in products such as…

  4. Cost-effectiveness of using a gene expression profiling test to aid in identifying the primary tumour in patients with cancer of unknown primary.

    Science.gov (United States)

    Hannouf, M B; Winquist, E; Mahmud, S M; Brackstone, M; Sarma, S; Rodrigues, G; Rogan, P; Hoch, J S; Zaric, G S

    2017-06-01

    We aimed to investigate the cost-effectiveness of a 2000-gene-expression profiling (GEP) test to help identify the primary tumor site when clinicopathological diagnostic evaluation was inconclusive in patients with cancer of unknown primary (CUP). We built a decision-analytic-model to project the lifetime clinical and economic consequences of different clinical management strategies for CUP. The model was parameterized using follow-up data from the Manitoba Cancer Registry, cost data from Manitoba Health administrative databases and secondary sources. The 2000-GEP-based strategy compared to current clinical practice resulted in an incremental cost-effectiveness ratio (ICER) of $44,151 per quality-adjusted life years (QALY) gained. The total annual-budget impact was $36.2 million per year. A value-of-information analysis revealed that the expected value of perfect information about the test's clinical impact was $4.2 million per year. The 2000-GEP test should be considered for adoption in CUP. Field evaluations of the test are associated with a large societal benefit.

  5. Profile of Students’ Critical Thinking Skill Measured by Science Virtual Test on Living Things and Environmental Sustainability Theme

    Science.gov (United States)

    Maulida, N. I.; Firman, H.; Rusyati, L.

    2017-02-01

    The aims of this study are: (1) to investigate the level of students’ critical thinking skill on living things and environmental sustainability theme for each Inch’ critical thinking elements and overall, (2) to investigate the level of students’ critical thinking skill on living things characteristic, biodiversity, energy resources, ecosystem, environmental pollution, and global warming topics. The research was conducted due to the important of critical thinking measurement to get the current skill description as the basic consideration for further critical thinking skill improvement in lower secondary science. The research method used was descriptive. 331 seventh grade students taken from five lower secondary schools in Cirebon were tested to get the critical thinking skill data by using Science Virtual Test as the instrument. Generally, the mean scores on eight Inch’ critical thinking elements and overall score from descriptive statistic reveals a moderate attainments level. Students’ critical thinking skill on biodiversity, energy resources, ecosystem, environmental pollution, and global warming topics are in moderate level. While students’ critical thinking skill on living things characteristic is identified as high level. Students’ experience in thinking critically during science learning process and the characteristic of the topic are emerged as the reason behind the students’ critical thinking skill level on certain science topic.

  6. Testing a symptom-based surveillance system at high-profile gatherings as a preparatory measure for bioterrorism.

    Science.gov (United States)

    Osaka, K; Takahashi, H; Ohyama, T

    2002-12-01

    We tested symptom-based surveillance during the G8 conference in 2000 as a means of detecting outbreaks, including bio-terrorism attacks, promptly. Five categories of symptoms (skin and haemorrhagic, respiratory, gastrointestinal, neurological and unexplained) were adopted for the case definition of the surveillance. The surveillance began I week before the conference, and continued until 1 week after the conference ended. We could not detect any outbreaks during this surveillance. Compared to the existing diagnosis-based surveillance system, symptom-based surveillance has the advantages of timeliness and simplicity. However, poor specificity and difficulties in determining epidemic threshold were important limitations of this system. To increase the specificity of surveillance, it is essential to incorporate rapid laboratory diagnoses into the system.

  7. Testing the Capacity of a Multi-Nutrient Profiling System to Guide Food and Beverage Reformulation: Results from Five National Food Composition Databases

    Directory of Open Access Journals (Sweden)

    Emilie Combet

    2017-04-01

    Full Text Available Nutrient profiling ranks foods based on their nutrient composition, with applications in multiple aspects of food policy. We tested the capacity of a category-specific model developed for product reformulation to improve the average nutrient content of foods, using five national food composition datasets (UK, US, China, Brazil, France. Products (n = 7183 were split into 35 categories based on the Nestlé Nutritional Profiling Systems (NNPS and were then classified as NNPS ‘Pass’ if all nutrient targets were met (energy (E, total fat (TF, saturated fat (SFA, sodium (Na, added sugars (AS, protein, calcium. In a modelling scenario, all NNPS Fail products were ‘reformulated’ to meet NNPS standards. Overall, a third (36% of all products achieved the NNPS standard/pass (inter-country and inter-category range: 32%–40%; 5%–72%, respectively, with most products requiring reformulation in two or more nutrients. The most common nutrients to require reformulation were SFA (22%–44% and TF (23%–42%. Modelled compliance with NNPS standards could reduce the average content of SFA, Na and AS (10%, 8% and 6%, respectively at the food supply level. Despite the good potential to stimulate reformulation across the five countries, the study highlights the need for better data quality and granularity of food composition databases.

  8. Testing the Capacity of a Multi-Nutrient Profiling System to Guide Food and Beverage Reformulation: Results from Five National Food Composition Databases.

    Science.gov (United States)

    Combet, Emilie; Vlassopoulos, Antonis; Mölenberg, Famke; Gressier, Mathilde; Privet, Lisa; Wratten, Craig; Sharif, Sahar; Vieux, Florent; Lehmann, Undine; Masset, Gabriel

    2017-04-21

    Nutrient profiling ranks foods based on their nutrient composition, with applications in multiple aspects of food policy. We tested the capacity of a category-specific model developed for product reformulation to improve the average nutrient content of foods, using five national food composition datasets (UK, US, China, Brazil, France). Products ( n = 7183) were split into 35 categories based on the Nestlé Nutritional Profiling Systems (NNPS) and were then classified as NNPS 'Pass' if all nutrient targets were met (energy (E), total fat (TF), saturated fat (SFA), sodium (Na), added sugars (AS), protein, calcium). In a modelling scenario, all NNPS Fail products were 'reformulated' to meet NNPS standards. Overall, a third (36%) of all products achieved the NNPS standard/pass (inter-country and inter-category range: 32%-40%; 5%-72%, respectively), with most products requiring reformulation in two or more nutrients. The most common nutrients to require reformulation were SFA (22%-44%) and TF (23%-42%). Modelled compliance with NNPS standards could reduce the average content of SFA, Na and AS (10%, 8% and 6%, respectively) at the food supply level. Despite the good potential to stimulate reformulation across the five countries, the study highlights the need for better data quality and granularity of food composition databases.

  9. Effect of chicory seed extract on glucose tolerance test (GTT and metabolic profile in early and late stage diabetic rats

    Directory of Open Access Journals (Sweden)

    Ali Ahadi

    2012-10-01

    Full Text Available Background and purpose of the study The goal was to evaluate and compare the effects of aqueous extract of the seeds of chicory, Cichorium intybus L., on glucose tolerance test (GTT and blood biochemical indices of experimentally-induced hyperglycemic rats.MethodsLate stage and early stage of Type 2 diabetes mellitus (T2DM were induced in rats by streptozotocin (STZ and a combination of STZ and niacinamide (NIA/STZ, respectively. Within each group, one subgroup received daily i. p. injections of chicory extract (125 mg/kg body weight, for 28 days. Body weight and fasting blood sugar (FBS were measured weekly. Blood was analyzed for glycosylated hemoglobin (HbA1c and sera for alanine aminotransferase (ALT, aspartate aminotransferase (AST, nitric oxide (NO, triacylglycerol (TG, total cholesterol (TC, total protein, and insulin on days 10 and 28 after treatment. Intraperitoneal glucose tolerance test (IPGTT along with insulin determination was performed on a different set of rats in which the chicory-treated groups received the extract for 10 days.ResultsDuring 4 weeks of treatment, chicory prevented body-weight loss and decreased FBS. ALT activities and levels of TG, TC and HbA1c decreased, and concentration of NO increased in the chicory treated groups (p < 0.05. Unlike late-stage diabetes, fasting serum insulin concentrations were higher and GTT pattern approximated to normal in chicory-treated earlystage diabetic rats.ConclusionsChicory appeared to have short-term (about 2 hours, as far as GTT is concerned and longterm (28 days, in this study effects on diabetes. Chicory may be useful as a natural dietary supplement for slowing down the pace of diabetes progress, and delaying the development of its complications.

  10. Effect of chicory seed extract on glucose tolerance test (GTT and metabolic profile in early and late stage diabetic rats

    Directory of Open Access Journals (Sweden)

    Ghamarian Abdolreza

    2012-10-01

    Full Text Available Abstract Background and purpose of the study The goal was to evaluate and compare the effects of aqueous extract of the seeds of chicory, Cichorium intybus L., on glucose tolerance test (GTT and blood biochemical indices of experimentally-induced hyperglycemic rats. Methods Late stage and early stage of Type 2 diabetes mellitus (T2DM were induced in rats by streptozotocin (STZ and a combination of STZ and niacinamide (NIA/STZ, respectively. Within each group, one subgroup received daily i. p. injections of chicory extract (125 mg/kg body weight, for 28 days. Body weight and fasting blood sugar (FBS were measured weekly. Blood was analyzed for glycosylated hemoglobin (HbA1c and sera for alanine aminotransferase (ALT, aspartate aminotransferase (AST, nitric oxide (NO, triacylglycerol (TG, total cholesterol (TC, total protein, and insulin on days 10 and 28 after treatment. Intraperitoneal glucose tolerance test (IPGTT along with insulin determination was performed on a different set of rats in which the chicory-treated groups received the extract for 10 days. Results During 4 weeks of treatment, chicory prevented body-weight loss and decreased FBS. ALT activities and levels of TG, TC and HbA1c decreased, and concentration of NO increased in the chicory treated groups (p Conclusions Chicory appeared to have short-term (about 2 hours, as far as GTT is concerned and long-term (28 days, in this study effects on diabetes. Chicory may be useful as a natural dietary supplement for slowing down the pace of diabetes progress, and delaying the development of its complications.

  11. Stability and economy analysis based on computational fluid dynamics and field testing of hybrid-driven underwater glider with the water quality sensor in Danjiangkou Reservoir

    Directory of Open Access Journals (Sweden)

    Chao Li

    2015-12-01

    Full Text Available Hybrid-driven underwater glider is a new kind of unmanned platform for water quality monitoring. It has advantages such as high controllability and maneuverability, low cost, easy operation, and ability to carry multiple sensors. This article develops a hybrid-driven underwater glider, PETRELII, and integrates a water quality monitoring sensor. Considering stability and economy, an optimal layout scheme is selected from four candidates by simulation using computational fluid dynamics method. Trials were carried out in Danjiangkou Reservoir—important headwaters of the Middle Route of the South-to-North Water Diversion Project. In the trials, a monitoring strategy with polygonal mixed-motion was adopted to make full use of the advantages of the unmanned platform. The measuring data, including temperature, dissolved oxygen, conductivity, pH, turbidity, chlorophyll, and ammonia nitrogen, are obtained. These data validate the practicability of the theoretical layout obtained using computational fluid dynamics method and the practical performance of PETRELII with sensor.

  12. Hybrid Qualifications

    DEFF Research Database (Denmark)

    Against the background of increasing qualification needs there is a growing awareness of the challenge to widen participation in processes of skill formation and competence development. At the same time, the issue of permeability between vocational education and training (VET) and general education...... has turned out as a major focus of European education and training policies and certainly is a crucial principle underlying the European Qualifications Framework (EQF). In this context, «hybrid qualifications» (HQ) may be seen as an interesting approach to tackle these challenges as they serve «two...

  13. Hybrid Gear

    Science.gov (United States)

    Handschuh, Robert F. (Inventor); Roberts, Gary D. (Inventor)

    2016-01-01

    A hybrid gear consisting of metallic outer rim with gear teeth and metallic hub in combination with a composite lay up between the shaft interface (hub) and gear tooth rim is described. The composite lay-up lightens the gear member while having similar torque carrying capability and it attenuates the impact loading driven noise/vibration that is typical in gear systems. The gear has the same operational capability with respect to shaft speed, torque, and temperature as an all-metallic gear as used in aerospace gear design.

  14. Hybrid spacecraft attitude control system

    Directory of Open Access Journals (Sweden)

    Renuganth Varatharajoo

    2016-02-01

    Full Text Available The hybrid subsystem design could be an attractive approach for futurespacecraft to cope with their demands. The idea of combining theconventional Attitude Control System and the Electrical Power System ispresented in this article. The Combined Energy and Attitude ControlSystem (CEACS consisting of a double counter rotating flywheel assemblyis investigated for small satellites in this article. Another hybrid systemincorporating the conventional Attitude Control System into the ThermalControl System forming the Combined Attitude and Thermal ControlSystem (CATCS consisting of a "fluid wheel" and permanent magnets isalso investigated for small satellites herein. The governing equationsdescribing both these novel hybrid subsystems are presented and theironboard architectures are numerically tested. Both the investigated novelhybrid spacecraft subsystems comply with the reference missionrequirements.The hybrid subsystem design could be an attractive approach for futurespacecraft to cope with their demands. The idea of combining theconventional Attitude Control System and the Electrical Power System ispresented in this article. The Combined Energy and Attitude ControlSystem (CEACS consisting of a double counter rotating flywheel assemblyis investigated for small satellites in this article. Another hybrid systemincorporating the conventional Attitude Control System into the ThermalControl System forming the Combined Attitude and Thermal ControlSystem (CATCS consisting of a "fluid wheel" and permanent magnets isalso investigated for small satellites herein. The governing equationsdescribing both these novel hybrid subsystems are presented and theironboard architectures are numerically tested. Both the investigated novelhybrid spacecraft subsystems comply with the reference missionrequirements.

  15. Design, Fabrication, and Testing of the INSTAR [INertial STorage And Recovery] System: A Flywheel-based, High Power Energy Storage System for Improved Hybrid Vehicle Fuel Efficiency

    OpenAIRE

    Talancon, Daniel Raul

    2015-01-01

    This thesis describes the development of the INSTAR system: a high-power, cost-effective energy storage system designed to improve HEV regenerative braking capabilities by combining chemical batteries with an electromechanical flywheel. This combination allows the regenerative braking system in hybrid vehicles to recapture more available braking energy at a lower battery pack charging current, increasing vehicle energy efficiency while also potentially increasing battery life.A prototype flyw...

  16. Hybrid superconducting magnetic suspensions

    International Nuclear Information System (INIS)

    Tixador, P.; Hiebel, P.; Brunet, Y.; Chaud, X.; Gautier-Picard, P.

    1996-01-01

    Superconductors, especially high T c ones, are the most attractive materials to design stable and fully passive magnetic suspensions which have to control five degrees of freedom. The hybrid superconducting magnetic suspensions present high performances and a simple cooling mode. They consist of a permanent magnet bearing, stabilized by a suitable magnet-superconductor structure. Several designs are given and compared in terms of forces and stiffnesses. The design of the magnet bearing plays an important part. The superconducting magnetic bearing participates less in levitation but must provide a high stabilizing stiffness. This is achieved by the magnet configuration, a good material in term of critical current density and field cooling. A hybrid superconducting suspension for a flywheel is presented. This system consists of a magnet thrust bearing stabilized by superconductors interacting with an alternating polarity magnet structure. First tests and results are reported. Superconducting materials are magnetically melt-textured YBaCuO

  17. Saponin profile of green asparagus genotypes.

    Science.gov (United States)

    Vázquez-Castilla, Sara; Jaramillo-Carmona, Sara; Fuentes-Alventosa, Jose María; Jiménez-Araujo, Ana; Rodríguez-Arcos, Rocío; Cermeño-Sacristán, Pedro; Espejo-Calvo, Juan Antonio; Guillén-Bejarano, Rafael

    2013-11-20

    The main goal of this study was to determine the saponin profiles of different "triguero" asparagus genotypes and to compare them to green asparagus commercial hybrids. The samples consisted of 31 commercial hybrids and 58 genotypes from the Huétor-Tájar (HT) population variety ("triguero"). The saponin analysis by high-performance liquid chromatography-mass spectrometry allowed for the determination of 12 saponins derived from a furostan-type steroidal genin, 4 of which had never been described in the edible part of asparagus. The saponin profile of "triguero" asparagus was a combination of these new saponins and protodioscin. Although protodioscin was the major saponin found in commercial hybrids, some of these 12 saponins were detected as major components in some of the commercial hybrids. The total contents of saponins described in some of these HT genotypes reach values as high as 10-100 times higher than those found in commercial hybrids.

  18. Release Profile and Inhibition Test of The Nanoparticles A. Paniculata Extract as Inhibitor of α-Glucosidase in The Process of Carbohydrates Breakdown Into Glucose Diabetes Mellitus

    Science.gov (United States)

    Imansari, Farisa; Sahlan, Muhammad; Arbianti, Rita

    2017-07-01

    Andrographis paniculata (A.paniculata) contain the main active substances Andrographolide which helps lower glucose levels in diabetics by inhibiting the enzyme α-glucosidase. The ability of the extract A.paniculata in lowering glucose levels will increase with the technique encapsulation with a coating of composition Chitosan-STPP as a drug delivery to the target organ. This study aimed to get an overview of A.paniculata release profile of nanoparticles in a synthetic fluid media with various concentrations of coating and inhibition testing nasty shard extract in inhibiting the enzyme α-glucosidase. This research resulted in nanoparticles by coating efficiency and loading capacity of chitosan greatest variation of 2% and 1% STPP 60% and 46.29%. chitosan greatest variation of 2% and 1% STPP 60% and 46.29%. The ability of A.paniculata extracts as α-glucosidase enzyme inhibitors has been demonstrated in this study, the percent inhibition of 33.17%.

  19. Status and test report on the LANL-Boeing APLE/HPO flying-wire beam-profile monitor. Status report

    Energy Technology Data Exchange (ETDEWEB)

    Wilke, M.; Barlow, D.; Fortgang, C.; Gilpatrick, J.; Meyer, R.; Rendon, A.; Warren, D. [Los Alamos National Lab., NM (United States); Greegor, R. [Boeing Co., Seattle, WA (United States)

    1994-07-01

    The High-Power Oscillator (HPO) demonstration of the Average Power Laser Experiment (APLE) is a collaboration by Los Alamos National Laboratory and Boeing to demonstrate a 10 kW average power, 10 {mu}m free electron laser (FEL). As part of the collaboration, Los Alamos National Laboratory (LANL) is responsible for many of the electron beam diagnostics in the linac, transport, and laser sections. Because of the high duty factor and power of the electron beam, special diagnostics are required. This report describes the flying wire diagnostic required to monitor the beam profile during high-power, high-duty operation. The authors describe the diagnostic and prototype tests on the Los Alamos APLE Prototype Experiment (APEX) FEL. They also describe the current status of the flying wires being built for APLE.

  20. DNA methylome profiling of maternal peripheral blood and placentas reveal potential fetal DNA markers for non-invasive prenatal testing.

    Science.gov (United States)

    Xiang, Yuqian; Zhang, Junyu; Li, Qiaoli; Zhou, Xinyao; Wang, Teng; Xu, Mingqing; Xia, Shihui; Xing, Qinghe; Wang, Lei; He, Lin; Zhao, Xinzhi

    2014-09-01

    Utilizing epigenetic (DNA methylation) differences to differentiate between maternal peripheral blood (PBL) and fetal (placental) DNA has been a promising strategy for non-invasive prenatal testing (NIPT). However, the differentially methylated regions (DMRs) have yet to be fully ascertained. In the present study, we performed genome-wide comparative methylome analysis between maternal PBL and placental DNA from pregnancies of first trimester by methylated DNA immunoprecipitation-sequencing (MeDIP-Seq) and Infinium HumanMethylation450 BeadChip assays. A total of 36 931 DMRs and 45 804 differentially methylated sites (DMSs) covering the whole genome, exclusive of the Y chromosome, were identified via MeDIP-Seq and Infinium 450k array, respectively, of which 3759 sites in 2188 regions were confirmed by both methods. Not only did we find the previously reported potential fetal DNA markers in our identified DMRs/DMSs but also we verified fully the identified DMRs/DMSs in the validation round by MassARRAY EpiTYPER. The screened potential fetal DNA markers may be used for NIPT on aneuploidies and other chromosomal diseases, such as cri du chat syndrome and velo-cardio-facial syndrome. In addition, these potential markers may have application in the early diagnosis of placental dysfunction, such as pre-eclampsia. © The Author 2014. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  1. Profile of a drunk driver and risk factors for drunk driving. Findings in roadside testing in the province of Uusimaa in Finland 1990-2008.

    Science.gov (United States)

    Portman, M; Penttilä, A; Haukka, J; Rajalin, S; Eriksson, C J P; Gunnar, T; Koskimaa, H; Kuoppasalmi, K

    2013-09-10

    The aim of the present study was to define the profile of a drunk driver and to determine risk factors for drunk driving by analyzing data on both sober and drunk drivers. Systematic roadside surveys have been carried out in Southern Finland for over 18 years, with 20,000-30,000 drivers breath tested annually. During the study period, 1241 drunk drivers were caught (legal blood alcohol limit 0.50‰). The comparison material consisted of 3407 sober drivers. The surveys were designed to further investigate demographic features and driving habits of drivers. The prevalence of drunk driving has been 0.2% over the time period, with only random variations. According to the data, a typical drunk driver is a man aged 40-49 who has a valid driving license and drives his own car, usually alone, with a blood alcohol concentration (BAC) of 1.0‰. He has a job and is married or cohabiting. The profile remained consistent throughout the study period. The risk of drunk driving was found to be five times higher for men than for women. Divorcees and widow(er)s had a substantially higher risk factor for being caught drunk driving than married drivers. Drunk drivers are most likely to be caught by roadside testing on Saturday mornings. During the study period the blood alcohol limit for aggravated drunk driving was lowered in 1994 from 1.5 to 1.2‰. In 2004 the taxation of alcohol beverages was reduced by 30%. Neither of these measures affected the prevalence of drunk driving or the mean BAC of drunk drivers (p=0.63). Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  2. In vitro and in vivo antifungal activity, liver profile test, and mutagenic activity of five plants used in traditional Mexican medicine

    Directory of Open Access Journals (Sweden)

    Jorge Cornejo-Garrido

    Full Text Available Berberis hartwegii Benth., Berberidaceae, Hamelia patens Jacq., Rubiaceae, Dendropanax arboreus (L. Decne & Planch., Araliaceae, Erythrina herbacea L., Fabaceae, and Zanthoxylum caribaeum Lam., Rutaceae, acetone extracts were selected on the basis of their use in traditional Mexican medicine to treat scabies or skin diseases. Anti-dermatophyte activity in vitro was evaluated using the agar dilution assay, and the therapeutic efficacy of B. hartwegii and Z. caribaeum were tested against experimental tinea pedis. The infected animals were treated intragastrically daily for seven days with 2.5 and 5 mg/kg of acetone extracts. The acetone extract of H. patens exhibited 100% growth inhibition against T. mentagrophytes and E. floccosum at 100.0 and 50.0 µg/ml, respectively, and B. hartwegii inhibited growth of M. canis and T. mentagrophytes at 100.0 µg/ml. Effective treatments with 2.5 mg/kg of Z. caribaeum and B. hartwegii extract were comparable with 1 mg/kg of clotrimazole in mice. Liver profile tests and histological analyses did not exhibit any signs of toxicity and the Ames test indicated that both extracts were safe when evaluated in strains TA98, TA100 and TA102. Our results suggest the potential for the future development of new antifungal drugs from B. hartwegii or Z. caribaeum.

  3. Intuitionistic hybrid logic

    DEFF Research Database (Denmark)

    Braüner, Torben

    2011-01-01

    Intuitionistic hybrid logic is hybrid modal logic over an intuitionistic logic basis instead of a classical logical basis. In this short paper we introduce intuitionistic hybrid logic and we give a survey of work in the area.......Intuitionistic hybrid logic is hybrid modal logic over an intuitionistic logic basis instead of a classical logical basis. In this short paper we introduce intuitionistic hybrid logic and we give a survey of work in the area....

  4. Test

    DEFF Research Database (Denmark)

    Bendixen, Carsten

    2014-01-01

    Bidrag med en kortfattet, introducerende, perspektiverende og begrebsafklarende fremstilling af begrebet test i det pædagogiske univers.......Bidrag med en kortfattet, introducerende, perspektiverende og begrebsafklarende fremstilling af begrebet test i det pædagogiske univers....

  5. Effect profile of paracetamol, Δ9-THC and promethazine using an evoked pain test battery in healthy subjects.

    Science.gov (United States)

    van Amerongen, G; Siebenga, P; de Kam, M L; Hay, J L; Groeneveld, G J

    2018-04-10

    A battery of evoked pain tasks (PainCart) was developed to investigate the pharmacodynamic properties of novel analgesics in early-phase clinical research. As part of its clinical validation, compounds with different pharmacological mechanisms of actions are investigated. The aim was to investigate the analgesic effects of classic and nonclassic analgesics compared to a sedating negative control in a randomized placebo-controlled crossover study in 24 healthy volunteers using the PainCart. The PainCart consisted of pain tasks eliciting electrical, pressure, heat, cold and inflammatory pain. Subjective scales for cognitive functioning and psychotomimetic effects were included. Subjects were administered each of the following oral treatments: paracetamol (1000 mg), Δ9-THC (10 mg), promethazine (50 mg) or matching placebo. Pharmacodynamic measurements were performed at baseline and repeated up to 10 h postdose. Paracetamol did not show a significant reduction in pain sensation or subjective cognitive functioning compared to placebo. Promethazine induced a statistically significant reduction in PTT for cold pressor and pressure stimulation. Furthermore, reduced subjective alertness was observed. Δ9-THC showed a statistically significant decrease in PTT for electrical and pressure stimulation. Δ9-THC also demonstrated subjective effects, including changes in alertness and calmness, as well as feeling high and psychotomimetic effects. This study found a decreased pain tolerance due to Δ9-THC and promethazine, or lack thereof, using an evoked pain task battery. Pain thresholds following paracetamol administration remained unchanged, which may be due to insufficient statistical power. We showed that pain thresholds determined using this pain test battery are not driven by sedation. The multimodal battery of evoked pain tasks utilized in this study may play an important role in early-phase clinical drug development. This battery of pain tasks is not sensitive to the

  6. Profiling spermatogenic failure in adult testes bearing Sox9-deficient Sertoli cells identifies genes involved in feminization, inflammation and stress

    Directory of Open Access Journals (Sweden)

    Barrionuevo Francisco

    2010-12-01

    Full Text Available Abstract Background Sox9 (Sry box containing gene 9 is a DNA-binding transcription factor involved in chondrocyte development and sex determination. The protein's absence in testicular Sertoli nurse cells has been shown to disrupt testicular function in adults but little is known at the genome-wide level about molecular events concomitant with testicular break-down. Methods To determine the genome-wide effect on mRNA concentrations triggered by the absence of Sox9 in Sertoli cells we analysed adult testicular tissue from wild-type versus mutant mice with high-density oligonucleotide microarrays and integrated the output of this experiment with regulatory motif predictions and protein-protein network data. Results We report the genome-wide mRNA signature of adult testes lacking Sox9 in Sertoli cells before and after the onset of late spermatogenic failure as compared to fertile controls. The GeneChip data integrated with evolutionarily conserved Sox9 DNA binding motifs and regulatory network data identified genes involved in feminization, stress response and inflammation. Conclusions Our results extend previous observations that genes required for female gonadogenesis are up-regulated in the absence of Sox9 in fetal Sertoli cells to the adult stage. Importantly, we identify gene networks involved in immunological processes and stress response which is reminiscent of a phenomenon occurring in a sub-group of infertile men. This suggests mice lacking Sox9 in their Sertoli cells to be a potentially useful model for adult human testicular failure.

  7. Insulin resistance and lipid profile during an oral glucose tolerance test in women with and without gestational diabetes mellitus.

    Science.gov (United States)

    Liang, Zx; Wu, Y; Zhu, Xy; Fang, Q; Chen, Dq

    2016-01-01

    We aimed to compare changes in insulin levels during an oral glucose tolerance test (OGTT) between women with normal glucose tolerance (NGT) during pregnancy and those with gestational diabetes mellitus (GDM). Overall, 105 pregnant women between 24 and 28 weeks' gestation, 50 with NGT and 55 with GDM according to NDDG standard, were enrolled into the study. The levels of fasting blood glucose, insulin, triglyceride (TG) and total cholesterol (TC) and the insulin levels, blood glucose levels at 1, 2 and 3 hours post oral glucose administration during an OGTT (5.8, 10.6, 9.2 and 8.1 mmol/L, respectively) were measured. Then, insulin resistance (IR) index was calculated. There was no significant difference in fasting, 3-h insulin levels and 3-h blood glucose levels between those with NGT and those with GDM (P > 0.05). However, 1-h and 2-h insulin levels, fasting and 1-h and 2-h blood glucose levels in women with GDM were significantly higher than those in the NGT group (P < 0.05). Fasting TC and TG levels in the GDM group were significantly higher than those with NGT (P = 0.031 and P = 0.025, respectively). Correlation analysis showed that TG and TC levels were positively correlated with homoeostasis model assessment-IR (HOMA-IR) (r = 0.67 and r = 0.78, respectively; P < 0.05). Our findings suggest that insulin sensitivity in women with GDM was significantly lower than that observed in those with NGT. Reducing IR and blood lipids in women with GDM could potentially improve maternal and foetal outcomes.

  8. The accuracy of prediction of genomic selection in elite hybrid rye populations surpasses the accuracy of marker-assisted selection and is equally augmented by multiple field evaluation locations and test years.

    Science.gov (United States)

    Wang, Yu; Mette, Michael Florian; Miedaner, Thomas; Gottwald, Marlen; Wilde, Peer; Reif, Jochen C; Zhao, Yusheng

    2014-07-04

    Marker-assisted selection (MAS) and genomic selection (GS) based on genome-wide marker data provide powerful tools to predict the genotypic value of selection material in plant breeding. However, case-to-case optimization of these approaches is required to achieve maximum accuracy of prediction with reasonable input. Based on extended field evaluation data for grain yield, plant height, starch content and total pentosan content of elite hybrid rye derived from testcrosses involving two bi-parental populations that were genotyped with 1048 molecular markers, we compared the accuracy of prediction of MAS and GS in a cross-validation approach. MAS delivered generally lower and in addition potentially over-estimated accuracies of prediction than GS by ridge regression best linear unbiased prediction (RR-BLUP). The grade of relatedness of the plant material included in the estimation and test sets clearly affected the accuracy of prediction of GS. Within each of the two bi-parental populations, accuracies differed depending on the relatedness of the respective parental lines. Across populations, accuracy increased when both populations contributed to estimation and test set. In contrast, accuracy of prediction based on an estimation set from one population to a test set from the other population was low despite that the two bi-parental segregating populations under scrutiny shared one parental line. Limiting the number of locations or years in field testing reduced the accuracy of prediction of GS equally, supporting the view that to establish robust GS calibration models a sufficient number of test locations is of similar importance as extended testing for more than one year. In hybrid rye, genomic selection is superior to marker-assisted selection. However, it achieves high accuracies of prediction only for selection candidates closely related to the plant material evaluated in field trials, resulting in a rather pessimistic prognosis for distantly related material

  9. Develop a Hybrid Coordinate Ocean Model with Data Assimilation Capabilities

    National Research Council Canada - National Science Library

    Thacker, W. C

    2003-01-01

    .... The objectives of the research are as follows: (1) to develop a methodology for assimilating temperature and salinity profiles from XBT, CTD, and ARGO float data that accommodates the peculiarities of HYCOM's hybrid vertical coordinates, allowing...

  10. Synthesis and anthelmintic activity of some hybrid Benzimidazolyl ...

    African Journals Online (AJOL)

    Erah

    parasites a major economic and food security issue. In this context ... a new hybrid chemical profile of chalcone and benzimidazole .... standard anthelmintic drugs (fenbendazole ... laboratory according to the classical Claisen-. Schmidt using.

  11. Hybridized Tetraquarks

    CERN Document Server

    Esposito, A.; Polosa, A.D.

    2016-01-01

    We propose a new interpretation of the neutral and charged X, Z exotic hadron resonances. Hybridized-tetraquarks are neither purely compact tetraquark states nor bound or loosely bound molecules. The latter would require a negative or zero binding energy whose counterpart in h-tetraquarks is a positive quantity. The formation mechanism of this new class of hadrons is inspired by that of Feshbach metastable states in atomic physics. The recent claim of an exotic resonance in the Bs pi+- channel by the D0 collaboration and the negative result presented subsequently by the LHCb collaboration are understood in this scheme, together with a considerable portion of available data on X, Z particles. Considerations on a state with the same quantum numbers as the X(5568) are also made.

  12. Test of hybrid power system for electrical vehicles using a lithium-ion battery pack and a reformed methanol fuel cell range extender

    DEFF Research Database (Denmark)

    Andreasen, Søren Juhl; Ashworth, Leanne; Sahlin, Simon Lennart

    2014-01-01

    is delivered by a lithium ion battery pack. In order to increase the run time of the application connected to this battery pack, a high temperature PEM (HTPEM) fuel cell stack acts as an on-board charger able to charge a vehicle during operation as a series hybrid. Because of the high tolerance to carbon...... a down-sized version of the battery pack used in the Mitsubishi iMiEV, which is subjected to power cycles derived from simulations of the vehicle undergoing multiple New European Drive Cycles (NEDC)....

  13. Policy-Led Comparative Environmental Risk Assessment of Genetically Modified Crops: Testing for Increased Risk Rather Than Profiling Phenotypes Leads to Predictable and Transparent Decision-Making

    Directory of Open Access Journals (Sweden)

    Alan Raybould

    2018-04-01

    Full Text Available We describe two contrasting methods of comparative environmental risk assessment for genetically modified (GM crops. Both are science-based, in the sense that they use science to help make decisions, but they differ in the relationship between science and policy. Policy-led comparative risk assessment begins by defining what would be regarded as unacceptable changes when the use a particular GM crop replaces an accepted use of another crop. Hypotheses that these changes will not occur are tested using existing or new data, and corroboration or falsification of the hypotheses is used to inform decision-making. Science-led comparative risk assessment, on the other hand, tends to test null hypotheses of no difference between a GM crop and a comparator. The variables that are compared may have little or no relevance to any previously stated policy objective and hence decision-making tends to be ad hoc in response to possibly spurious statistical significance. We argue that policy-led comparative risk assessment is the far more effective method. With this in mind, we caution that phenotypic profiling of GM crops, particularly with omics methods, is potentially detrimental to risk assessment.

  14. Species hybridization in the genus Pinus

    Science.gov (United States)

    Peter W. Garrett

    1979-01-01

    Results of a breeding program in which a large number of pine species were tested indicate that a number of species and hybrids may be useful in the northeastern United States. Austrian black pine x Japanese black pine and hybrids containing Japanese red pine all had good growth rates. While none of the soft pines grew faster than eastern white pine, a number of...

  15. Somatic hybridization of sexually incompatible petunias: Petunia parodii, Petunia parviflora.

    Science.gov (United States)

    Power, J B; Berry, S F; Chapman, J V; Cocking, E C

    1980-01-01

    Somatic hybrid plants were regenerated following the fusion of leaf mesophyll protoplasts of P. parodii with those isolated from a nuclear-albino mutant of P. parviflora. Attempts at sexual hybridization of these two species repeatedly failed thus confirming their previously established cross-incompatibility. Selection of somatic hybrid plants was possible since protoplasts of P. parodii would not develop beyond the cell colony stage, whilst those of the somatic hybrid and albino P. parviflora produced calluses. Green somatic hybrid calluses were visible against a background of albino cells/calluses, and upon transfer to regeneration media gave rise to shoots. Shoots and the resultant flowering plants were confirmed as somatic hybrids based on their growth habit, floral pigmentation and morphology, leaf hair structure, chromosome number and Fraction 1 protein profiles. The relevance of such hybrid material for the development of new, and extensively modified cultivars, is discussed.

  16. Continuity controlled Hybrid Automata

    NARCIS (Netherlands)

    Bergstra, J.A.; Middelburg, C.A.

    We investigate the connections between the process algebra for hybrid systems of Bergstra and Middelburg and the formalism of hybrid automata of Henzinger et al. We give interpretations of hybrid automata in the process algebra for hybrid systems and compare them with the standard interpretation

  17. Continuity Controlled Hybrid Automata

    NARCIS (Netherlands)

    Bergstra, J.A.; Middelburg, C.A.

    2004-01-01

    We investigate the connections between the process algebra for hybrid systems of Bergstra and Middelburg and the formalism of hybrid automata of Henzinger et al. We give interpretations of hybrid automata in the process algebra for hybrid systems and compare them with the standard interpretation of

  18. Continuity controlled hybrid automata

    NARCIS (Netherlands)

    Bergstra, J.A.; Middelburg, C.A.

    2004-01-01

    We investigate the connections between the process algebra for hybrid systems of Bergstra and Middelburg and the formalism of hybrid automata of Henzinger et al. We give interpretations of hybrid automata in the process algebra for hybrid systems and compare them with the standard interpretation of

  19. Continuity controlled hybrid automata

    NARCIS (Netherlands)

    Bergstra, J.A.; Middelburg, C.A.

    2006-01-01

    We investigate the connections between the process algebra for hybrid systems of Bergstra and Middelburg and the formalism of hybrid automata of Henzinger et al. We give interpretations of hybrid automata in the process algebra for hybrid systems and compare them with the standard interpretation of

  20. Molecular evidence for natural hybridization in the mangrove genus avicennia

    International Nuclear Information System (INIS)

    Huang, L.; Huang Y; Shi, S.; Zhou, R

    2014-01-01

    Hybridization has been observed in several multi-species genera of mangroves; however, there has been no report on hybridization in Avicennia in the Indo-West Pacific region. In this study, we sequenced 5 low-copy nuclear genes of Avicennia marina, A. rumphiana and 2 individuals of their putative hybrid in the Southeast Asia region to test the hypothesis of natural hybridization between these 2 species. We demonstrated that both putative hybrid individuals possessed two types of sequences at each of the 5 genes, perfectly corresponding to those of A. marina and A. rumphiana, confirming the hybridization between these 2 Avicennia species, and the 2 hybrid individuals are most likely F1 hybrids. Sequencing of the chloroplast trnH-psbA regions indicated that A. marina was the maternal parent of the two hybrid individuals. (author)