WorldWideScience

Sample records for hybrid imaging state-of-the-art

  1. State of the art magnetic resonance imaging

    International Nuclear Information System (INIS)

    Weissman, J.D.

    1987-01-01

    In less than a decade Magnetic Resonance Imaging (MRI) has evolved from a laboratory demonstration to a safe and effective technique for clinical diagnosis. This evolutionary process continues. At this time 2-D and 3-D imaging of the head and body is firmly established in clinical use. Surface coil imaging, two-component chemical shift imaging, in-vivo spectroscopy and flow imaging are currently in various stages of development. The present state of the art of MRI is a function of an array of technologies: magnet, Rf coil, Rf pulse amplifier, gradient coil and driver, pulse programmer, A/D converter, computer system architecture, array processors and mass storage (both magnetic and optical). The overall product design is the result of a complex process which balances the advantages and disadvantages of each component for optimal system performance and flexibility. The author discusses the organization of a state-of-the-art MRI system. Several examples of the kinds of system interactions affecting design choices are given. (Auth.)

  2. Imaging Acute Appendicitis: State of the Art

    Directory of Open Access Journals (Sweden)

    Diana Gaitini

    2011-01-01

    Full Text Available The goal of this review is to present the state of the art in imaging tests for the diagnosis of acute appendicitis. Relevant publications regarding performance and advantages/disadvantages of imaging modalities for the diagnosis of appendicitis in different clinical situations were reviewed. Articles were extracted from a computerized database (MEDLINE with the following activated limits: Humans, English, core clinical journals, and published in the last five years. Reference lists of relevant studies were checked manually to identify additional, related articles. Ultrasound (US examination should be the first imaging test performed, particularly among the pediatric and young adult populations, who represent the main targets for appendicitis, as well as in pregnant patients. A positive US examination for appendicitis or an alternative diagnosis of possible gastrointestinal or urological origin, or a negative US, either showing a normal appendix or presenting low clinical suspicion of appendicitis, should lead to a final diagnosis. A negative or indeterminate examination with a strong clinical suspicion of appendicitis should be followed by a computed tomography (CT scan or alternatively, a magnetic resonanace imaging (MRI scan in a pregnant patient. A second US examination in a patient with persistent symptoms, especially if the first one was performed by a less experienced imaging professional, is a valid alternative to a CT.

  3. CMOS image sensors: State-of-the-art

    Science.gov (United States)

    Theuwissen, Albert J. P.

    2008-09-01

    This paper gives an overview of the state-of-the-art of CMOS image sensors. The main focus is put on the shrinkage of the pixels : what is the effect on the performance characteristics of the imagers and on the various physical parameters of the camera ? How is the CMOS pixel architecture optimized to cope with the negative performance effects of the ever-shrinking pixel size ? On the other hand, the smaller dimensions in CMOS technology allow further integration on column level and even on pixel level. This will make CMOS imagers even smarter that they are already.

  4. Multimodality image registration with software: state-of-the-art

    Energy Technology Data Exchange (ETDEWEB)

    Slomka, Piotr J. [Cedars-Sinai Medical Center, AIM Program/Department of Imaging, Los Angeles, CA (United States); University of California, David Geffen School of Medicine, Los Angeles, CA (United States); Baum, Richard P. [Center for PET, Department of Nuclear Medicine, Bad Berka (Germany)

    2009-03-15

    Multimodality image integration of functional and anatomical data can be performed by means of dedicated hybrid imaging systems or by software image co-registration techniques. Hybrid positron emission tomography (PET)/computed tomography (CT) systems have found wide acceptance in oncological imaging, while software registration techniques have a significant role in patient-specific, cost-effective, and radiation dose-effective application of integrated imaging. Software techniques allow accurate (2-3 mm) rigid image registration of brain PET with CT and MRI. Nonlinear techniques are used in whole-body image registration, and recent developments allow for significantly accelerated computing times. Nonlinear software registration of PET with CT or MRI is required for multimodality radiation planning. Difficulties remain in the validation of nonlinear registration of soft tissue organs. The utilization of software-based multimodality image integration in a clinical environment is sometimes hindered by the lack of appropriate picture archiving and communication systems (PACS) infrastructure needed to efficiently and automatically integrate all available images into one common database. In cardiology applications, multimodality PET/single photon emission computed tomography and coronary CT angiography imaging is typically not required unless the results of one of the tests are equivocal. Software image registration is likely to be used in a complementary fashion with hybrid PET/CT or PET/magnetic resonance imaging systems. Software registration of stand-alone scans ''paved the way'' for the clinical application of hybrid scanners, demonstrating practical benefits of image integration before the hybrid dual-modality devices were available. (orig.)

  5. Multimodality image registration with software: state-of-the-art

    International Nuclear Information System (INIS)

    Slomka, Piotr J.; Baum, Richard P.

    2009-01-01

    Multimodality image integration of functional and anatomical data can be performed by means of dedicated hybrid imaging systems or by software image co-registration techniques. Hybrid positron emission tomography (PET)/computed tomography (CT) systems have found wide acceptance in oncological imaging, while software registration techniques have a significant role in patient-specific, cost-effective, and radiation dose-effective application of integrated imaging. Software techniques allow accurate (2-3 mm) rigid image registration of brain PET with CT and MRI. Nonlinear techniques are used in whole-body image registration, and recent developments allow for significantly accelerated computing times. Nonlinear software registration of PET with CT or MRI is required for multimodality radiation planning. Difficulties remain in the validation of nonlinear registration of soft tissue organs. The utilization of software-based multimodality image integration in a clinical environment is sometimes hindered by the lack of appropriate picture archiving and communication systems (PACS) infrastructure needed to efficiently and automatically integrate all available images into one common database. In cardiology applications, multimodality PET/single photon emission computed tomography and coronary CT angiography imaging is typically not required unless the results of one of the tests are equivocal. Software image registration is likely to be used in a complementary fashion with hybrid PET/CT or PET/magnetic resonance imaging systems. Software registration of stand-alone scans ''paved the way'' for the clinical application of hybrid scanners, demonstrating practical benefits of image integration before the hybrid dual-modality devices were available. (orig.)

  6. PET/MRI in Oncological Imaging: State of the Art

    Science.gov (United States)

    Bashir, Usman; Mallia, Andrew; Stirling, James; Joemon, John; MacKewn, Jane; Charles-Edwards, Geoff; Goh, Vicky; Cook, Gary J.

    2015-01-01

    Positron emission tomography (PET) combined with magnetic resonance imaging (MRI) is a hybrid technology which has recently gained interest as a potential cancer imaging tool. Compared with CT, MRI is advantageous due to its lack of ionizing radiation, superior soft-tissue contrast resolution, and wider range of acquisition sequences. Several studies have shown PET/MRI to be equivalent to PET/CT in most oncological applications, possibly superior in certain body parts, e.g., head and neck, pelvis, and in certain situations, e.g., cancer recurrence. This review will update the readers on recent advances in PET/MRI technology and review key literature, while highlighting the strengths and weaknesses of PET/MRI in cancer imaging. PMID:26854157

  7. PET/MRI in Oncological Imaging: State of the Art

    Directory of Open Access Journals (Sweden)

    Usman Bashir

    2015-07-01

    Full Text Available Positron emission tomography (PET combined with magnetic resonance imaging (MRI is a hybrid technology which has recently gained interest as a potential cancer imaging tool. Compared with CT, MRI is advantageous due to its lack of ionizing radiation, superior soft-tissue contrast resolution, and wider range of acquisition sequences. Several studies have shown PET/MRI to be equivalent to PET/CT in most oncological applications, possibly superior in certain body parts, e.g., head and neck, pelvis, and in certain situations, e.g., cancer recurrence. This review will update the readers on recent advances in PET/MRI technology and review key literature, while highlighting the strengths and weaknesses of PET/MRI in cancer imaging.

  8. Prosthetic joint infections: radionuclide state-of-the-art imaging

    Energy Technology Data Exchange (ETDEWEB)

    Gemmel, Filip [AZ Alma Campus Sijsele, Department of Nuclear Medicine, Sijsele-Damme (Belgium); Wyngaert, Hans van den [AZ Alma Campus Sijsele, Department of Orthopaedic Surgery, Sijsele-Damme (Belgium); Love, Charito [Albert Einstein College of Medicine of Yeshiva University, Division of Nuclear Medicine and Radiology, Bronx, NY (United States); Welling, M.M. [Leiden University Medical Center, Scientist Molecular Imaging, Department of Radiology, Section of Nuclear Medicine C2-203, Leiden (Netherlands); Gemmel, Paul [Ghent University, The Faculty of Economics and Business Administration, Ghent (Belgium); Palestro, Christopher J. [Hofstra North Shore-Long Island Jewish Health System, Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Hempstead, NY (United States)

    2012-05-15

    has been devoted to developing alternative radiotracers, such as radiolabelled HIGs, liposomes, antigranulocyte antibodies and fragments, as well as more investigational tracers such as radiolabelled antibiotics, antimicrobial peptides, bacteriophages and thymidine kinase. On the other hand, positron emission tomography (PET) is still growing in the field of PJI imaging with radiotracers such as {sup 18}F-fluorodeoxyglucose (FDG), {sup 18}F-FDG white blood cells and {sup 18}F-fluoride. But unfortunately this superb tomographic technique will only receive full acceptance when specific PET uptake patterns can be successfully developed. The emergence of hybrid modality imaging using integrated single photon emission computed tomography (SPECT) and PET with computed tomography (SPECT/CT and PET/CT) may also have a contributing role for more accurate assessment of joint replacement complications, especially combined with new radiotracers such as {sup 68}Ga and {sup 64}Cu. Finally, in searching for infection-specific tracers, currently there is no such diagnostic agent available. (orig.)

  9. Prosthetic joint infections: radionuclide state-of-the-art imaging

    International Nuclear Information System (INIS)

    Gemmel, Filip; Wyngaert, Hans van den; Love, Charito; Welling, M.M.; Gemmel, Paul; Palestro, Christopher J.

    2012-01-01

    has been devoted to developing alternative radiotracers, such as radiolabelled HIGs, liposomes, antigranulocyte antibodies and fragments, as well as more investigational tracers such as radiolabelled antibiotics, antimicrobial peptides, bacteriophages and thymidine kinase. On the other hand, positron emission tomography (PET) is still growing in the field of PJI imaging with radiotracers such as 18 F-fluorodeoxyglucose (FDG), 18 F-FDG white blood cells and 18 F-fluoride. But unfortunately this superb tomographic technique will only receive full acceptance when specific PET uptake patterns can be successfully developed. The emergence of hybrid modality imaging using integrated single photon emission computed tomography (SPECT) and PET with computed tomography (SPECT/CT and PET/CT) may also have a contributing role for more accurate assessment of joint replacement complications, especially combined with new radiotracers such as 68 Ga and 64 Cu. Finally, in searching for infection-specific tracers, currently there is no such diagnostic agent available. (orig.)

  10. Interventional MR imaging: state of the art and future perspectives

    International Nuclear Information System (INIS)

    Kahn, T.; Moedder, U.

    1998-01-01

    The concept of MR guidance of invasive diagnostic and minimally invasive therapeutic procedures is based on the excellent morphologic and functional properties of MR imaging. Prerequisites are adequate patient monitoring and adherence to safety guidelines. Fast and ultrafast sequences, temperature quantification, visualization of intravascular devices, thermal stability of contrast media and thermosensitive contrast media are discussed. The spectrum of clinical applications includes biopsies, thermal ablation modalities, vascular applications, MR endoscopy and intraoperative MR imaging. The development of interventional MR imaging is still in its infancy. In the future, MR imaging may play an important role in interventional radiology and minimally invasive therapy. (orig.) [de

  11. Imaging of Brown Adipose Tissue: State of the Art.

    Science.gov (United States)

    Sampath, Srihari C; Sampath, Srinath C; Bredella, Miriam A; Cypess, Aaron M; Torriani, Martin

    2016-07-01

    The rates of diabetes, obesity, and metabolic disease have reached epidemic proportions worldwide. In recent years there has been renewed interest in combating these diseases not only by modifying energy intake and lifestyle factors, but also by inducing endogenous energy expenditure. This approach has largely been stimulated by the recent recognition that brown adipose tissue (BAT)-long known to promote heat production and energy expenditure in infants and hibernating mammals-also exists in adult humans. This landmark finding relied on the use of clinical fluorine 18 fluorodeoxyglucose positron emission tomography/computed tomography, and imaging techniques continue to play a crucial and increasingly central role in understanding BAT physiology and function. Herein, the authors review the origins of BAT imaging, discuss current preclinical and clinical strategies for imaging BAT, and discuss imaging methods that will provide crucial insight into metabolic disease and how it may be treated by modulating BAT activity. (©) RSNA, 2016.

  12. State-of-the-art imaging of peritoneal carcinomatosis

    International Nuclear Information System (INIS)

    Pfannenberg, C.; Schwenzer, N.F.; Bruecher, B.L.

    2012-01-01

    Imaging studies are essential in the evaluation of patients with suspected or known peritoneal malignancy. Despite major advances in imaging technology in the last few years, the early and adequate detection of a peritoneal dissemination remains challenging because of the great variety in size, morphology and location of the peritoneal lesions. New therapeutic approaches in peritoneal-based neoplasms combining cytoreductive surgery and peritonectomy with hyperthermic intraoperative chemotherapy (HIPEC) suggest improved long-term survival, provided that a complete (macroscopic) cytoreduction is achieved. The preoperative radiological assessment of the extent and distribution of peritoneal involvement plays a vital role in the patient selection process. Despite its known limited accuracy in detecting small peritoneal lesions and the involvement of the small bowel/mesentery, contrast-enhanced MDCT remains the standard imaging modality in the assessment of peritoneal carcinomatosis. MRI, especially with diffusion-weighted images, and FDG-PET/CT are promising methods for the evaluation of peritoneal carcinomatosis with superior results in recent studies, but still have a limited role in selected cases because of high costs and limited availability. Generally, to obtain the most precise readings of peritoneal carcinomatosis, an optimized examination protocol and dedicated radiologists with a deep knowledge of peritoneal pathways and variable morphologies of peritoneal disease are required. (orig.)

  13. Practical steganalysis of digital images: state of the art

    Science.gov (United States)

    Fridrich, Jessica; Goljan, Miroslav

    2002-04-01

    Steganography is the art of hiding the very presence of communication by embedding secret messages into innocuous looking cover documents, such as digital images. Detection of steganography, estimation of message length, and its extraction belong to the field of steganalysis. Steganalysis has recently received a great deal of attention both from law enforcement and the media. In our paper, we classify and review current stego-detection algorithms that can be used to trace popular steganographic products. We recognize several qualitatively different approaches to practical steganalysis - visual detection, detection based on first order statistics (histogram analysis), dual statistics methods that use spatial correlations in images and higher-order statistics (RS steganalysis), universal blind detection schemes, and special cases, such as JPEG compatibility steganalysis. We also present some new results regarding our previously proposed detection of LSB embedding using sensitive dual statistics. The recent steganalytic methods indicate that the most common paradigm in image steganography - the bit-replacement or bit substitution - is inherently insecure with safe capacities far smaller than previously thought.

  14. Ultrasound imaging in urogynecology – state of the art 2016

    Directory of Open Access Journals (Sweden)

    Michał Bogusiewicz

    2016-11-01

    Full Text Available The role of ultrasound imaging in urogynecology is not clearly defined. Despite significant developments in visualization techniques and interpretation of images, pelvic ultrasound is still more a tool for research than for clinical practice. Structures of the lower genitourinary tract and pelvic floor can be visualized from different approaches: transperineal, introital, transvaginal, abdominal or endoanal. According to contemporary guidelines and recommendations, the role of ultrasound in urogynecology is limited to the measurement of post-void residue. However, in many instances, including planning and audit of surgical procedures, management of recurrences or complications, ultrasound may be proposed as the initial examination of choice. Ultrasound may be used for assessment of bladder neck mobility before anti-incontinence procedures. On rare occasions it is helpful in recognition of pathologies mimicking vaginal prolapse such as vaginal cyst, urethral diverticula or rectal intussusception. In patients subjected to suburethral slings, causes of surgery failure or postsurgical voiding dysfunctions can be revealed by imaging. Many reports link the location of a tape close to the bladder neck to unfavorable outcomes of sling surgery. Some postoperative complications, such as urinary retention, mesh malposition, hematoma, or urinary tract injury, can be diagnosed by ultrasound. On the other hand, the clinical value of some applications of ultrasound in urogynecology, for example measurement of the bladder wall thickness as a marker of detrusor overactivity, has not been proved.

  15. Image-guided breast biopsy: state-of-the-art

    Energy Technology Data Exchange (ETDEWEB)

    O' Flynn, E.A.M., E-mail: lizoflynn@doctors.org.u [South East London Breast Screening Programme and National Breast Screening Training Centre, Kings College Hospital NHS Foundation Trust, London SE5 9RS (United Kingdom); Wilson, A.R.M.; Michell, M.J. [South East London Breast Screening Programme and National Breast Screening Training Centre, Kings College Hospital NHS Foundation Trust, London SE5 9RS (United Kingdom)

    2010-04-15

    Percutaneous image-guided breast biopsy is widely practised to evaluate predominantly non-palpable breast lesions. There has been steady development in percutaneous biopsy techniques. Fine-needle aspiration cytology was the original method of sampling, followed in the early 1990s by large core needle biopsy. The accuracy of both has been improved by ultrasound and stereotactic guidance. Larger bore vacuum-assisted biopsy devices became available in the late 1990s and are now commonplace in most breast units. We review the different types of breast biopsy devices currently available together with various localization techniques used, focusing on their advantages, limitations and current controversial clinical management issues.

  16. State-of-the-art assessment of electric vehicles and hybrid vehicles

    Science.gov (United States)

    1977-01-01

    The Electric and Hybrid Vehicle Research, Development, and Demonstration Act of 1976 (PL 94-413) requires that data be developed to characterize the state of the art of vehicles powered by an electric motor and those propelled by a combination of an electric motor and an internal combustion engine or other power sources. Data obtained from controlled tests of a representative number of sample vehicles, from information supplied by manufacturers or contained in the literature, and from surveys of fleet operators of individual owners of electric vehicles is discussed. The results of track and dynamometer tests conducted by NASA on 22 electric, 2 hybrid, and 5 conventional vehicles, as well as on 5 spark-ignition-engine-powered vehicles, the conventional counterparts of 5 of the vehicles, are presented.

  17. Thermal imagers: from ancient analog video output to state-of-the-art video streaming

    Science.gov (United States)

    Haan, Hubertus; Feuchter, Timo; Münzberg, Mario; Fritze, Jörg; Schlemmer, Harry

    2013-06-01

    The video output of thermal imagers stayed constant over almost two decades. When the famous Common Modules were employed a thermal image at first was presented to the observer in the eye piece only. In the early 1990s TV cameras were attached and the standard output was CCIR. In the civil camera market output standards changed to digital formats a decade ago with digital video streaming being nowadays state-of-the-art. The reasons why the output technique in the thermal world stayed unchanged over such a long time are: the very conservative view of the military community, long planning and turn-around times of programs and a slower growth of pixel number of TIs in comparison to consumer cameras. With megapixel detectors the CCIR output format is not sufficient any longer. The paper discusses the state-of-the-art compression and streaming solutions for TIs.

  18. State-of-the-art radiation detectors for medical imaging: Demands and trends

    Energy Technology Data Exchange (ETDEWEB)

    Darambara, Dimitra G. [Joint Department of Physics, Royal Marsden Foundation Trust and Institute of Cancer Research, Fulham Road, London SW3 6JJ (United Kingdom)]. E-mail: dimitra.darambara@icr.ac.uk

    2006-12-20

    Over the last half-century a variety of significant technical advances in several scientific fields has been pointing to an exploding growth in the field of medical imaging leading to a better interpretation of more specific anatomical, biochemical and molecular pathways. In particular, the development of novel imaging detectors and readout electronics has been critical to the advancement of medical imaging allowing the invention of breakthrough platforms for simultaneous acquisition of multi-modality images at molecular level. The present paper presents a review of the challenges, demands and constraints on radiation imaging detectors imposed by the nature of the modality and the physics of the imaging source. This is followed by a concise review and perspective on various types of state-of-the-art detector technologies that have been developed to meet these requirements. Trends, prospects and new concepts for future imaging detectors are also highlighted.

  19. State-of-the-art radiation detectors for medical imaging: Demands and trends

    International Nuclear Information System (INIS)

    Darambara, Dimitra G.

    2006-01-01

    Over the last half-century a variety of significant technical advances in several scientific fields has been pointing to an exploding growth in the field of medical imaging leading to a better interpretation of more specific anatomical, biochemical and molecular pathways. In particular, the development of novel imaging detectors and readout electronics has been critical to the advancement of medical imaging allowing the invention of breakthrough platforms for simultaneous acquisition of multi-modality images at molecular level. The present paper presents a review of the challenges, demands and constraints on radiation imaging detectors imposed by the nature of the modality and the physics of the imaging source. This is followed by a concise review and perspective on various types of state-of-the-art detector technologies that have been developed to meet these requirements. Trends, prospects and new concepts for future imaging detectors are also highlighted

  20. Statistical dynamic image reconstruction in state-of-the-art high-resolution PET

    International Nuclear Information System (INIS)

    Rahmim, Arman; Cheng, J-C; Blinder, Stephan; Camborde, Maurie-Laure; Sossi, Vesna

    2005-01-01

    Modern high-resolution PET is now more than ever in need of scrutiny into the nature and limitations of the imaging modality itself as well as image reconstruction techniques. In this work, we have reviewed, analysed and addressed the following three considerations within the particular context of state-of-the-art dynamic PET imaging: (i) the typical average numbers of events per line-of-response (LOR) are now (much) less than unity (ii) due to the physical and biological decay of the activity distribution, one requires robust and efficient reconstruction algorithms applicable to a wide range of statistics and (iii) the computational considerations in dynamic imaging are much enhanced (i.e., more frames to be stored and reconstructed). Within the framework of statistical image reconstruction, we have argued theoretically and shown experimentally that the sinogram non-negativity constraint (when using the delayed-coincidence and/or scatter-subtraction techniques) is especially expected to result in an overestimation bias. Subsequently, two schemes are considered: (a) subtraction techniques in which an image non-negativity constraint has been imposed and (b) implementation of random and scatter estimates inside the reconstruction algorithms, thus enabling direct processing of Poisson-distributed prompts. Both techniques are able to remove the aforementioned bias, while the latter, being better conditioned theoretically, is able to exhibit superior noise characteristics. We have also elaborated upon and verified the applicability of the accelerated list-mode image reconstruction method as a powerful solution for accurate, robust and efficient dynamic reconstructions of high-resolution data (as well as a number of additional benefits in the context of state-of-the-art PET)

  1. Magnetic resonance imaging of the cardiovascular system: present state of the art and future potential

    International Nuclear Information System (INIS)

    Jacobson, H.G.

    1988-01-01

    State-of-the-art magnetic resonance imaging (MRI) generates high-resolution images of the cardiovascular system. Conventional MRI techniques provide images in six to ten minutes per tomographic slice. New strategies have substantially improved the speed of imaging. The technology is relatively expensive, and its cost-effectiveness remains to be defined in relation to other effective, less expensive, and noninvasive technologies, such as echocardiography and nuclear medicine. The ultimate role of MRI will depend on several factors, including the development of specific applications such as (1) noninvasive angiography, especially of the coronary arteries;(2) noninvasive, high-resolution assessment of regional myocardial blood flow distribution (e.g., using paramagnetic contrast agents); (3) characterization of myocardial diseases using proton-relaxation property changes; and (4) evaluation of in vivo myocardial biochemistry. The three-dimensional imaging capability and the ability to image cardiovascular structures without contrast material give MRI a potential advantage over existing noninvasive diagnostic imaging techniques. This report analyzes current applications of MRI to the cardiovascular system and speculates on their future

  2. Perspectives on State-of-the-Art Carbon Nanotube/Polyaniline and Graphene/Polyaniline Composites for Hybrid Supercapacitor Electrodes.

    Science.gov (United States)

    Srikanth, Vadali V S S; Ramana, Gedela Venkata; Kumar, Puttapati Sampath

    2016-03-01

    Supercapacitors are attractive alternative energy storage sources. They offer high energy/power density with other characteristics like fast discharge/charge time, long operation stability, safety etc. In a supercapacitor, working electrode material is the principal constituent. At present there are numerous electrode materials (with properties) suitable for their use in hybrid type supercapacitors. Carbon/polyaniline (PANi) composites are one class of such electrode materials. Here, perspectives on state-of-the-art carbon/PANi composites namely carbon nanotube/polyaniline and graphene/polyaniline composites expedient as hybrid type supercapacitor electrode materials will be presented.

  3. Deep machine learning provides state-of-the-art performance in image-based plant phenotyping.

    Science.gov (United States)

    Pound, Michael P; Atkinson, Jonathan A; Townsend, Alexandra J; Wilson, Michael H; Griffiths, Marcus; Jackson, Aaron S; Bulat, Adrian; Tzimiropoulos, Georgios; Wells, Darren M; Murchie, Erik H; Pridmore, Tony P; French, Andrew P

    2017-10-01

    In plant phenotyping, it has become important to be able to measure many features on large image sets in order to aid genetic discovery. The size of the datasets, now often captured robotically, often precludes manual inspection, hence the motivation for finding a fully automated approach. Deep learning is an emerging field that promises unparalleled results on many data analysis problems. Building on artificial neural networks, deep approaches have many more hidden layers in the network, and hence have greater discriminative and predictive power. We demonstrate the use of such approaches as part of a plant phenotyping pipeline. We show the success offered by such techniques when applied to the challenging problem of image-based plant phenotyping and demonstrate state-of-the-art results (>97% accuracy) for root and shoot feature identification and localization. We use fully automated trait identification using deep learning to identify quantitative trait loci in root architecture datasets. The majority (12 out of 14) of manually identified quantitative trait loci were also discovered using our automated approach based on deep learning detection to locate plant features. We have shown deep learning-based phenotyping to have very good detection and localization accuracy in validation and testing image sets. We have shown that such features can be used to derive meaningful biological traits, which in turn can be used in quantitative trait loci discovery pipelines. This process can be completely automated. We predict a paradigm shift in image-based phenotyping bought about by such deep learning approaches, given sufficient training sets. © The Authors 2017. Published by Oxford University Press.

  4. Imaging Spectrometry of Inland and Coastal Waters: State of the Art, Achievements and Perspectives

    Science.gov (United States)

    Giardino, C.; Brando, V. E.; Gege, P.; Pinnel, N.; Hochberg, E.; Knaeps, E.; Reusen, I.; Doerffer, R.; Bresciani, M.; Braga, F.; Foerster, S.; Champollion, N.; Dekker, A.

    2018-06-01

    Imaging spectrometry of non-oceanic aquatic ecosystems has been in development since the late 1980s when the first airborne hyperspectral sensors were deployed over lakes. Most water quality management applications were, however, developed using multispectral mid-spatial resolution satellites or coarse spatial resolution ocean colour satellites till now. This situation is about to change with a suite of upcoming imaging spectrometers being deployed from experimental satellites or from the International Space Station. We review the science of developing applications for inland and coastal aquatic ecosystems that often are a mixture of optically shallow and optically deep waters, with gradients of clear to turbid and oligotrophic to hypertrophic productive waters and with varying bottom visibility with and without macrophytes, macro-algae, benthic micro-algae or corals. As the spaceborne, airborne and in situ optical sensors become increasingly available and appropriate for aquatic ecosystem detection, monitoring and assessment, the science-based applications will need to be further developed to an operational level. The Earth Observation-derived information products will range from more accurate estimates of turbidity and transparency measures, chlorophyll, suspended matter and coloured dissolved organic matter concentration, to more sophisticated products such as particle size distributions, phytoplankton functional types or distinguishing sources of suspended and coloured dissolved matter, estimating water depth and mapping types of heterogeneous substrates. We provide an overview of past science, current state of the art and future directions so that early career scientists as well as aquatic ecosystem managers and associated industry groups may be prepared for the imminent deluge of imaging spectrometry data.

  5. State-of-the-art assessment of electric and hybrid vehicles

    Science.gov (United States)

    1978-01-01

    Data are presented that were obtained from the electric and hybrid vehicles tested, information collected from users of electric vehicles, and data and information on electric and hybrid vehicles obtained on a worldwide basis from manufacturers and available literature. The data given include: (1) information and data base (electric and hybrid vehicle systems descriptions, sources of vehicle data and information, and sources of component data); (2) electric vehicles (theoretical background, electric vehicle track tests, user experience, literature data, and summary of electric vehicle status); (3) electric vehicle components (tires, differentials, transmissions, traction motors, controllers, batteries, battery chargers, and component summary); and (4) hybrid vehicles (types of hybrid vehicles, operating modes, hybrid vehicles components, and hybrid vehicles performance characteristics).

  6. Denoising of Microscopy Images: A Review of the State-of-the-Art, and a New Sparsity-Based Method.

    Science.gov (United States)

    Meiniel, William; Olivo-Marin, Jean-Christophe; Angelini, Elsa D

    2018-08-01

    This paper reviews the state-of-the-art in denoising methods for biological microscopy images and introduces a new and original sparsity-based algorithm. The proposed method combines total variation (TV) spatial regularization, enhancement of low-frequency information, and aggregation of sparse estimators and is able to handle simple and complex types of noise (Gaussian, Poisson, and mixed), without any a priori model and with a single set of parameter values. An extended comparison is also presented, that evaluates the denoising performance of the thirteen (including ours) state-of-the-art denoising methods specifically designed to handle the different types of noises found in bioimaging. Quantitative and qualitative results on synthetic and real images show that the proposed method outperforms the other ones on the majority of the tested scenarios.

  7. A state-of-the-art review on hybrid heat pipe latent heat storage systems

    International Nuclear Information System (INIS)

    Naghavi, M.S.; Ong, K.S.; Mehrali, M.; Badruddin, I.A.; Metselaar, H.S.C.

    2015-01-01

    The main advantage of latent heat thermal energy storage systems is the capability to store a large quantity of thermal energy in an isothermal process by changing phase from solid to liquid, while the most important weakness of these systems is low thermal conductivity that leads to unsuitable charging/discharging rates. Heat pipes are used in many applications – as one of the most efficient heat exchanger devices – to amplify the charging/discharging processes rate and are used to transfer heat from a source to the storage or from the storage to a sink. This review presents and critically discusses previous investigations and analysis on the incorporation of heat pipe devices into latent heat thermal energy storage with heat pipe devices. This paper categorizes different applications and configurations such as low/high temperature solar, heat exchanger and cooling systems, analytical approaches and effective parameters on the performance of hybrid HP–LHTES systems.

  8. 3D-2D registration in endovascular image-guided surgery: evaluation of state-of-the-art methods on cerebral angiograms.

    Science.gov (United States)

    Mitrović, Uroš; Likar, Boštjan; Pernuš, Franjo; Špiclin, Žiga

    2018-02-01

    Image guidance for minimally invasive surgery is based on spatial co-registration and fusion of 3D pre-interventional images and treatment plans with the 2D live intra-interventional images. The spatial co-registration or 3D-2D registration is the key enabling technology; however, the performance of state-of-the-art automated methods is rather unclear as they have not been assessed under the same test conditions. Herein we perform a quantitative and comparative evaluation of ten state-of-the-art methods for 3D-2D registration on a public dataset of clinical angiograms. Image database consisted of 3D and 2D angiograms of 25 patients undergoing treatment for cerebral aneurysms or arteriovenous malformations. On each of the datasets, highly accurate "gold-standard" registrations of 3D and 2D images were established based on patient-attached fiducial markers. The database was used to rigorously evaluate ten state-of-the-art 3D-2D registration methods, namely two intensity-, two gradient-, three feature-based and three hybrid methods, both for registration of 3D pre-interventional image to monoplane or biplane 2D images. Intensity-based methods were most accurate in all tests (0.3 mm). One of the hybrid methods was most robust with 98.75% of successful registrations (SR) and capture range of 18 mm for registrations of 3D to biplane 2D angiograms. In general, registration accuracy was similar whether registration of 3D image was performed onto mono- or biplanar 2D images; however, the SR was substantially lower in case of 3D to monoplane 2D registration. Two feature-based and two hybrid methods had clinically feasible execution times in the order of a second. Performance of methods seems to fall below expectations in terms of robustness in case of registration of 3D to monoplane 2D images, while translation into clinical image guidance systems seems readily feasible for methods that perform registration of the 3D pre-interventional image onto biplanar intra

  9. The state of the art of medical imaging technology: from creation to archive and back.

    Science.gov (United States)

    Gao, Xiaohong W; Qian, Yu; Hui, Rui

    2011-01-01

    Medical imaging has learnt itself well into modern medicine and revolutionized medical industry in the last 30 years. Stemming from the discovery of X-ray by Nobel laureate Wilhelm Roentgen, radiology was born, leading to the creation of large quantities of digital images as opposed to film-based medium. While this rich supply of images provides immeasurable information that would otherwise not be possible to obtain, medical images pose great challenges in archiving them safe from corrupted, lost and misuse, retrievable from databases of huge sizes with varying forms of metadata, and reusable when new tools for data mining and new media for data storing become available. This paper provides a summative account on the creation of medical imaging tomography, the development of image archiving systems and the innovation from the existing acquired image data pools. The focus of this paper is on content-based image retrieval (CBIR), in particular, for 3D images, which is exemplified by our developed online e-learning system, MIRAGE, home to a repository of medical images with variety of domains and different dimensions. In terms of novelties, the facilities of CBIR for 3D images coupled with image annotation in a fully automatic fashion have been developed and implemented in the system, resonating with future versatile, flexible and sustainable medical image databases that can reap new innovations.

  10. A state-of-the-art review on segmentation algorithms in intravascular ultrasound (IVUS) images.

    Science.gov (United States)

    Katouzian, Amin; Angelini, Elsa D; Carlier, Stéphane G; Suri, Jasjit S; Navab, Nassir; Laine, Andrew F

    2012-09-01

    Over the past two decades, intravascular ultrasound (IVUS) image segmentation has remained a challenge for researchers while the use of this imaging modality is rapidly growing in catheterization procedures and in research studies. IVUS provides cross-sectional grayscale images of the arterial wall and the extent of atherosclerotic plaques with high spatial resolution in real time. In this paper, we review recently developed image processing methods for the detection of media-adventitia and luminal borders in IVUS images acquired with different transducers operating at frequencies ranging from 20 to 45 MHz. We discuss methodological challenges, lack of diversity in reported datasets, and weaknesses of quantification metrics that make IVUS segmentation still an open problem despite all efforts. In conclusion, we call for a common reference database, validation metrics, and ground-truth definition with which new and existing algorithms could be benchmarked.

  11. State of the art in both in vitro and in vivo aspects of small animal imaging

    International Nuclear Information System (INIS)

    Maziere, B.; Lebars, D.

    2002-01-01

    Full text: In vivo imaging for small animals is dramatically expanding due to the coincidence of mainly three technical factors: 1. the explosion in computer power 2. the enhancement in image processing 3. the accessibility and affordability of digital autoradiography systems and small-animal scanners. Among these imaging techniques let us mention the anatomical imaging techniques such as ultrasonography, X-rays and IRM and the functional imaging radioisotopic techniques SPECT and TEP. The main advantage of the first group of imaging techniques is essentially linked to the high resolution of the anatomical images (with the drawback of the necessity of putting the animal at rest using anaesthesia). The main advantages of SPECT and PET are their high sensitivity and the vast number of functions or metabolism they allow to image. The applications for isotopic functional imaging in small animals are increasing rapidly. Factors contributing to this dramatic expansion include the three previous technical factors plus, at least, three methodological factors: 1. the drug discovery process based on receptor / mechanism of action 2. the increasing number of rodent models of human diseases (SCID mice implanted with human tumors, gene knock-out mice, transgene mice) 3. the advances in isotope and validated tracer availability performances Small animal radioisotopic functional imaging for drug development. In vivo quantification of biological processes to measure the mechanism of action of a potential drug and its concentration at the site of action has become mandatory for developing a drug. Rational and efficient means of confirming mechanisms of action are required. For this purpose, PET and/or SPECT functional - biochemical - molecular imaging in small animals are tools of choice for economical reasons (in the domain of drug development, industry is suffering huge opportunity costs by failing to weed out non-performing new active substances until late phases II and III) and

  12. State-of-the-art of small animal imaging with high-resolution SPECT

    International Nuclear Information System (INIS)

    Nikolaus, S.; Wirrwar, A.; Antke, C.; Kley, K.; Mueller, H.W.

    2005-01-01

    During the recent years, in vivo imaging of small animals using SPECT has become of growing relevance. Along with the development of dedicated high-resolution small animal SPECT cameras, an increasing number of conventional clinical scanners has been equipped with single or multipinhole collimators. This paper reviews the small animal tomographs, which are operating at present and compares their performance characteristics. Furthermore, we describe the in vivo imaging studies, which have been performed so far with the individual scanners and survey current approaches to optimize molecular imaging with small animal SPECT. (orig.)

  13. PET and SPECT imaging of melanoma: the state of the art

    Energy Technology Data Exchange (ETDEWEB)

    Wei, Weijun [Shanghai Jiao Tong University Affiliated Sixth People' s Hospital, Department of Nuclear Medicine, Shanghai (China); University of Wisconsin-Madison, Department of Radiology, Madison, WI (United States); Ehlerding, Emily B. [University of Wisconsin-Madison, Department of Medical Physics, Madison, WI (United States); Lan, Xiaoli [Huazhong University of Science and Technology (China); Hubei Key Laboratory of Molecular Imaging, Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Wuhan (China); Luo, Quanyong [Shanghai Jiao Tong University Affiliated Sixth People' s Hospital, Department of Nuclear Medicine, Shanghai (China); Cai, Weibo [University of Wisconsin-Madison, Department of Radiology, Madison, WI (United States); University of Wisconsin-Madison, Department of Medical Physics, Madison, WI (United States); University of Wisconsin Carbone Cancer Center, Madison, WI (United States)

    2018-01-15

    Melanoma represents the most aggressive form of skin cancer, and its incidence continues to rise worldwide. {sup 18}F-FDG PET imaging has transformed diagnostic nuclear medicine and has become an essential component in the management of melanoma, but still has its drawbacks. With the rapid growth in the field of nuclear medicine and molecular imaging, a variety of promising probes that enable early diagnosis and detection of melanoma have been developed. The substantial preclinical success of melanin- and peptide-based probes has recently resulted in the translation of several radiotracers to clinical settings for noninvasive imaging and treatment of melanoma in humans. In this review, we focus on the latest developments in radiolabeled molecular imaging probes for melanoma in preclinical and clinical settings, and discuss the challenges and opportunities for future development. (orig.)

  14. PET and SPECT imaging of melanoma: the state of the art

    International Nuclear Information System (INIS)

    Wei, Weijun; Ehlerding, Emily B.; Lan, Xiaoli; Luo, Quanyong; Cai, Weibo

    2018-01-01

    Melanoma represents the most aggressive form of skin cancer, and its incidence continues to rise worldwide. 18 F-FDG PET imaging has transformed diagnostic nuclear medicine and has become an essential component in the management of melanoma, but still has its drawbacks. With the rapid growth in the field of nuclear medicine and molecular imaging, a variety of promising probes that enable early diagnosis and detection of melanoma have been developed. The substantial preclinical success of melanin- and peptide-based probes has recently resulted in the translation of several radiotracers to clinical settings for noninvasive imaging and treatment of melanoma in humans. In this review, we focus on the latest developments in radiolabeled molecular imaging probes for melanoma in preclinical and clinical settings, and discuss the challenges and opportunities for future development. (orig.)

  15. Information hiding techniques for infrared images: exploring the state-of-the art and challenges

    Science.gov (United States)

    Pomponiu, Victor; Cavagnino, Davide; Botta, Marco; Nejati, Hossein

    2015-10-01

    The proliferation of Infrared technology and imaging systems enables a different perspective to tackle many computer vision problems in defense and security applications. Infrared images are widely used by the law enforcement, Homeland Security and military organizations to achieve a significant advantage or situational awareness, and thus is vital to protect these data against malicious attacks. Concurrently, sophisticated malware are developed which are able to disrupt the security and integrity of these digital media. For instance, illegal distribution and manipulation are possible malicious attacks to the digital objects. In this paper we explore the use of a new layer of defense for the integrity of the infrared images through the aid of information hiding techniques such as watermarking. In this context, we analyze the efficiency of several optimal decoding schemes for the watermark inserted into the Singular Value Decomposition (SVD) domain of the IR images using an additive spread spectrum (SS) embedding framework. In order to use the singular values (SVs) of the IR images with the SS embedding we adopt several restrictions that ensure that the values of the SVs will maintain their statistics. For both the optimal maximum likelihood decoder and sub-optimal decoders we assume that the PDF of SVs can be modeled by the Weibull distribution. Furthermore, we investigate the challenges involved in protecting and assuring the integrity of IR images such as data complexity and the error probability behavior, i.e., the probability of detection and the probability of false detection, for the applied optimal decoders. By taking into account the efficiency and the necessary auxiliary information for decoding the watermark, we discuss the suitable decoder for various operating situations. Experimental results are carried out on a large dataset of IR images to show the imperceptibility and efficiency of the proposed scheme against various attack scenarios.

  16. Ultrasound Imaging of Spine: State of the Art and Utility for Space Flight

    Science.gov (United States)

    Sargsyan, Ashot E.; Bouffard, Antonio J.; Garcia, Kathleen; Hamilton, Douglas R.; Van Holsbeeck, Marnix; Ebert, Douglas J. W.; Dulchavsky, Scott A.

    2010-01-01

    Introduction: Ultrasound imaging (sonography) has been increasingly used for both primary diagnosis and monitoring of musculoskeletal injury, including fractures. In certain injuries, sonography has been shown to equal or surpass Magnetic Resonance Imaging in accuracy. Long-term exposure to reduced gravity may be expected to cause physiological and anatomical changes of the musculoskeletal system, which are not fully described or understood. In a limited-resource environment like space flight, sonography will likely remain the only imaging modality; therefore, further attention to its potential is warranted, including its ability to image anatomical deviations as well as irregularities of vertebrae and the spinal column. Methods: A thorough review of literature was conducted on the subject. A multipurpose ultrasound system was used to identify specific vertebrae, intervertebral disks, and other structures of the cervical spine in healthy volunteers, selected to represent various age, gender, and Body Mass Index (BMI) groups. Sonographic views were sought that would parallel radiographic views and signs used in the diagnosis of cervical spine injuries. Results: While using widely accepted radiographic signs of cervical spine injury, this sonographic protocol development effort resulted in successful identification of scanning planes and imaging protocols that could serve as alternatives for radiography. Some of these views are also applicable to diagnosing degenerative disk and bone disease, and other non-traumatic spine pathology. Strong, preliminary correlation has been demonstrated in a number of clinical cases between sonography and other imaging modalities. Conclusion: In the absence of radiography, sonography can be used to diagnose or rule out certain common types of cervical spine conditions including injury. Clinical validation of the findings appears to be realistic and would facilitate establishment of new sonographic protocols for special environments

  17. State of the art: noninvasive imaging and management of neurovascular trauma

    Directory of Open Access Journals (Sweden)

    Cothren C Clay

    2007-01-01

    Full Text Available Abstract Neurotrauma represents a significant public health problem, accounting for a significant proportion of the morbidity and mortality associated with all traumatic injuries. Both blunt and penetrating injuries to cervicocerebral vessels are significant and are likely more common than previously recognized. Imaging of such injuries is an important component in the evaluation of individuals presenting with such potential injuries, made all the more important since many of the vascular injuries are clinically silent. Management of injuries, particularly those caused by blunt trauma, is constantly evolving. This article addresses the current state of imaging and treatment of such injuries.

  18. Whole-body magnetic resonance imaging in children: state of the art

    Directory of Open Access Journals (Sweden)

    Sara Reis Teixeira

    2015-04-01

    Full Text Available Whole-body imaging in children was classically performed with radiography, positron-emission tomography, either combined or not with computed tomography, the latter with the disadvantage of exposure to ionizing radiation. Whole-body magnetic resonance imaging (MRI, in association with the recently developed metabolic and functional techniques such as diffusion-weighted imaging, has brought the advantage of a comprehensive evaluation of pediatric patients without the risks inherent to ionizing radiation usually present in other conventional imaging methods. It is a rapid and sensitive method, particularly in pediatrics, for detecting and monitoring multifocal lesions in the body as a whole. In pediatrics, it is utilized for both oncologic and non-oncologic indications such as screening and diagnosis of tumors in patients with genetic syndromes, evaluation of disease extent and staging, evaluation of therapeutic response and post-therapy follow-up, evaluation of non neoplastic diseases such as multifocal osteomyelitis, vascular malformations and syndromes affecting multiple regions of the body. The present review was aimed at describing the major indications of whole-body MRI in pediatrics added of technical considerations.

  19. Cardiovascular magnetic resonance imaging in hypertrophic cardiomyopathy: Current state of the art.

    Science.gov (United States)

    Kamal, Muhammad Umar; Riaz, Irbaz Bin; Janardhanan, Rajesh

    2016-01-01

    Hypertrophic cardiomyopathy (HCM) is the most common genetic cardiomyopathy with a prevalence of 1:500 (0.2%) in the general population. Sudden cardiac death (SCD) is the most feared presentation of HCM. Therefore, it is essential to identify individuals at high risk in order to prevent SCD. The absence of conventional risk factors does not nullify the risk of HCM related SCD. Although echocardiography is currently the most widely used imaging modality, cardiac magnetic resonance (CMR) allows detailed characterization of the HCM phenotype, which makes it possible to differentiate HCM from other causes of left ventricular hypertrophy. CMR has the potential to further refine risk stratification. Late gadolinium enhancement (LGE) on CMR is a high-risk feature and there is emerging data to suggest that the presence of LGE should be employed as a marker for major adverse outcomes such as SCD, arrhythmias, systolic and diastolic heart failure. Hence, LGE on CMR may be considered an additional risk factor for SCD in HCM patients and should be incorporated in decision-making for implant-able cardioverter defibrillator implantation to aid primary prevention. Novel markers such as the extent of myocardial fibrosis on CMR must be accounted for comprehensive risk stratifica-tion of HCM patients. The purpose of this review is to discuss the current status and emerging role of CMR in HCM.

  20. State of the Art of X-ray Speckle-Based Phase-Contrast and Dark-Field Imaging

    Directory of Open Access Journals (Sweden)

    Marie-Christine Zdora

    2018-04-01

    Full Text Available In the past few years, X-ray phase-contrast and dark-field imaging have evolved to be invaluable tools for non-destructive sample visualisation, delivering information inaccessible by conventional absorption imaging. X-ray phase-sensing techniques are furthermore increasingly used for at-wavelength metrology and optics characterisation. One of the latest additions to the group of differential phase-contrast methods is the X-ray speckle-based technique. It has drawn significant attention due to its simple and flexible experimental arrangement, cost-effectiveness and multimodal character, amongst others. Since its first demonstration at highly brilliant synchrotron sources, the method has seen rapid development, including the translation to polychromatic laboratory sources and extension to higher-energy X-rays. Recently, different advanced acquisition schemes have been proposed to tackle some of the main limitations of previous implementations. Current applications of the speckle-based method range from optics characterisation and wavefront measurement to biomedical imaging and materials science. This review provides an overview of the state of the art of the X-ray speckle-based technique. Its basic principles and different experimental implementations as well as the the latest advances and applications are illustrated. In the end, an outlook for anticipated future developments of this promising technique is given.

  1. Fuel cells: state of the art

    International Nuclear Information System (INIS)

    Campanari, S.; Casalegno, A.

    2007-01-01

    This paper deals with the main features at present state-of-the-art fuel cell and hybrid cycle technologies, discussing their actual performance, possible applications, market entry perspectives and potential development [it

  2. Current State-of-the-Art 3D Tissue Models and Their Compatibility with Live Cell Imaging.

    Science.gov (United States)

    Bardsley, Katie; Deegan, Anthony J; El Haj, Alicia; Yang, Ying

    2017-01-01

    Mammalian cells grow within a complex three-dimensional (3D) microenvironment where multiple cells are organized and surrounded by extracellular matrix (ECM). The quantity and types of ECM components, alongside cell-to-cell and cell-to-matrix interactions dictate cellular differentiation, proliferation and function in vivo. To mimic natural cellular activities, various 3D tissue culture models have been established to replace conventional two dimensional (2D) culture environments. Allowing for both characterization and visualization of cellular activities within possibly bulky 3D tissue models presents considerable challenges due to the increased thickness and subsequent light scattering features of such 3D models. In this chapter, state-of-the-art methodologies used to establish 3D tissue models are discussed, first with a focus on both scaffold-free and scaffold-based 3D tissue model formation. Following on, multiple 3D live cell imaging systems, mainly optical imaging modalities, are introduced. Their advantages and disadvantages are discussed, with the aim of stimulating more research in this highly demanding research area.

  3. Radiomics and its emerging role in lung cancer research, imaging biomarkers and clinical management: State of the art

    International Nuclear Information System (INIS)

    Lee, Geewon; Lee, Ho Yun; Park, Hyunjin; Schiebler, Mark L.; Beek, Edwin J.R. van; Ohno, Yoshiharu; Seo, Joon Beom; Leung, Ann

    2017-01-01

    Highlights: • Radiomics is the post-processing and analysis of large amounts of quantitative imaging features that can be derived from medical images. • Radiomics features can reflect the spatial complexity, genomic heterogeneity, and subregional identification of lung cancer. • Currently available radiomic features can be divided into four major categories. • The major challenge is to integrate radiomic data with clinical, pathological, and genomic information. - Abstract: With the development of functional imaging modalities we now have the ability to study the microenvironment of lung cancer and its genomic instability. Radiomics is defined as the use of automated or semi-automated post-processing and analysis of large amounts of quantitative imaging features that can be derived from medical images. The automated generation of these analytical features helps to quantify a number of variables in the imaging assessment of lung malignancy. These imaging features include: tumor spatial complexity, elucidation of the tumor genomic heterogeneity and composition, subregional identification in terms of tumor viability or aggressiveness, and response to chemotherapy and/or radiation. Therefore, a radiomic approach can help to reveal unique information about tumor behavior. Currently available radiomic features can be divided into four major classes: (a) morphological, (b) statistical, (c) regional, and (d) model-based. Each category yields quantitative parameters that reflect specific aspects of a tumor. The major challenge is to integrate radiomic data with clinical, pathological, and genomic information to decode the different types of tissue biology. There are many currently available radiomic studies on lung cancer for which there is a need to summarize the current state of the art.

  4. Radiomics and its emerging role in lung cancer research, imaging biomarkers and clinical management: State of the art

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Geewon [Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of); Department of Radiology and Medical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine, Busan (Korea, Republic of); Lee, Ho Yun, E-mail: hoyunlee96@gmail.com [Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of); Park, Hyunjin [School of Electronic and Electrical Engineering and Center for Neuroscience Imaging Research, Sungkyunkwan University, Suwon (Korea, Republic of); Schiebler, Mark L. [Department of Radiology, UW-Madison School of Medicine and Public Health, Madison, WI (United States); Beek, Edwin J.R. van [Clinical Research Imaging Centre, Edinburgh Imaging, Queen' s Medical Research Institute, University of Edinburgh, Edinburgh (United Kingdom); Ohno, Yoshiharu [Division of Functional and Diagnostic Imaging Research, Department of Radiology, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe-shi 650-0017 (Japan); Advanced Biomedical Imaging Research Center, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe-shi 650-0017 (Japan); Seo, Joon Beom [Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul (Korea, Republic of); Leung, Ann [Department of Radiology, Stanford University, Palo Alto, CA (United States)

    2017-01-15

    Highlights: • Radiomics is the post-processing and analysis of large amounts of quantitative imaging features that can be derived from medical images. • Radiomics features can reflect the spatial complexity, genomic heterogeneity, and subregional identification of lung cancer. • Currently available radiomic features can be divided into four major categories. • The major challenge is to integrate radiomic data with clinical, pathological, and genomic information. - Abstract: With the development of functional imaging modalities we now have the ability to study the microenvironment of lung cancer and its genomic instability. Radiomics is defined as the use of automated or semi-automated post-processing and analysis of large amounts of quantitative imaging features that can be derived from medical images. The automated generation of these analytical features helps to quantify a number of variables in the imaging assessment of lung malignancy. These imaging features include: tumor spatial complexity, elucidation of the tumor genomic heterogeneity and composition, subregional identification in terms of tumor viability or aggressiveness, and response to chemotherapy and/or radiation. Therefore, a radiomic approach can help to reveal unique information about tumor behavior. Currently available radiomic features can be divided into four major classes: (a) morphological, (b) statistical, (c) regional, and (d) model-based. Each category yields quantitative parameters that reflect specific aspects of a tumor. The major challenge is to integrate radiomic data with clinical, pathological, and genomic information to decode the different types of tissue biology. There are many currently available radiomic studies on lung cancer for which there is a need to summarize the current state of the art.

  5. Basic pathologies of neurodegenerative dementias and their relevance for state-of-the-art molecular imaging studies

    International Nuclear Information System (INIS)

    Drzezga, Alexander

    2008-01-01

    regarded to be strongly associated with the development of different dementias, will be shortly summarized; it will also be discussed how state-of-the-art imaging technology can assist to visualize these processes now and in the future. (orig.)

  6. Can state-of-the-art HVS-based objective image quality criteria be used for image reconstruction techniques based on ROI analysis?

    Science.gov (United States)

    Dostal, P.; Krasula, L.; Klima, M.

    2012-06-01

    Various image processing techniques in multimedia technology are optimized using visual attention feature of the human visual system. Spatial non-uniformity causes that different locations in an image are of different importance in terms of perception of the image. In other words, the perceived image quality depends mainly on the quality of important locations known as regions of interest. The performance of such techniques is measured by subjective evaluation or objective image quality criteria. Many state-of-the-art objective metrics are based on HVS properties; SSIM, MS-SSIM based on image structural information, VIF based on the information that human brain can ideally gain from the reference image or FSIM utilizing the low-level features to assign the different importance to each location in the image. But still none of these objective metrics utilize the analysis of regions of interest. We solve the question if these objective metrics can be used for effective evaluation of images reconstructed by processing techniques based on ROI analysis utilizing high-level features. In this paper authors show that the state-of-the-art objective metrics do not correlate well with subjective evaluation while the demosaicing based on ROI analysis is used for reconstruction. The ROI were computed from "ground truth" visual attention data. The algorithm combining two known demosaicing techniques on the basis of ROI location is proposed to reconstruct the ROI in fine quality while the rest of image is reconstructed with low quality. The color image reconstructed by this ROI approach was compared with selected demosaicing techniques by objective criteria and subjective testing. The qualitative comparison of the objective and subjective results indicates that the state-of-the-art objective metrics are still not suitable for evaluation image processing techniques based on ROI analysis and new criteria is demanded.

  7. State of the art

    International Nuclear Information System (INIS)

    Lederman, L.M.

    1983-01-01

    There is a large body of experience in high luminosity data taking in fixed target research. We try to consider a wide variety of high rate experiments which were limited by the detector (not by available beam) to a preset number of collisions per second. We then attempt to translate these state-of-the-art experiments to effective collider experiments. To this end, we extend the chosen detector to a comparison 4π collider detector operating near 1 TeV. There are several issues: (1) effective solid angle must be translated to approx. = 4π, (2) environments may be quite different, e.g., beam dump near fixed target or beam halo muons vs. collider backgrounds, (3) the multiplicity varies over the experiments selected and (4) we have to treat open vs closed geometries. The large variety of experiments selected is designed to average over the causes for detector limitation. Finally we chose detectors which have produced physics in order to gauge the state of the art

  8. Dynamic comparison of PET imaging performance between state-of-the-art ToF-PET/CT and ToF-PET/MR scanners

    International Nuclear Information System (INIS)

    Delso, Gaspar; Deller, Tim; Khalighi, Mehdi; Veit-Haibach, Patrick; Schulthess, Gustav von

    2014-01-01

    The goal of the present work was to determine the potential for dose reduction in a new clinical ToF-PET/MR scanner. This was achieved by means of long dynamic phantom acquisitions designed to provide a fair comparison of image quality and lesion detectability, as a function of activity, between the new PET/MR system and a state-of-the art PET/CT.

  9. Digital Airborne Photogrammetry—A New Tool for Quantitative Remote Sensing?—A State-of-the-Art Review On Radiometric Aspects of Digital Photogrammetric Images

    Directory of Open Access Journals (Sweden)

    Nikolaj Veje

    2009-09-01

    Full Text Available The transition from film imaging to digital imaging in photogrammetric data capture is opening interesting possibilities for photogrammetric processes. A great advantage of digital sensors is their radiometric potential. This article presents a state-of-the-art review on the radiometric aspects of digital photogrammetric images. The analysis is based on a literature research and a questionnaire submitted to various interest groups related to the photogrammetric process. An important contribution to this paper is a characterization of the photogrammetric image acquisition and image product generation systems. The questionnaire revealed many weaknesses in current processes, but the future prospects of radiometrically quantitative photogrammetry are promising.

  10. Hybrid systems for transuranic waste transmutation in nuclear power reactors: state of the art and future prospects

    Science.gov (United States)

    Yurov, D. V.; Prikhod'ko, V. V.

    2014-11-01

    The features of subcritical hybrid systems (HSs) are discussed in the context of burning up transuranic wastes from the U-Pu nuclear fuel cycle. The advantages of HSs over conventional atomic reactors are considered, and fuel cycle closure alternatives using HSs and fast neutron reactors are comparatively evaluated. The advantages and disadvantages of two HS types with neutron sources (NSs) of widely different natures -- nuclear spallation in a heavy target by protons and nuclear fusion in magnetically confined plasma -- are discussed in detail. The strengths and weaknesses of HSs are examined, and demand for them for closing the U-Pu nuclear fuel cycle is assessed.

  11. State of the art imaging of multiple myeloma: Comparative review of FDG PET/CT imaging in various clinical settings

    Energy Technology Data Exchange (ETDEWEB)

    Mesguich, Charles, E-mail: charles.mesguich@chu-bordeaux.fr [Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY (United States); Fardanesh, Reza; Tanenbaum, Lawrence [Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY (United States); Chari, Ajai; Jagannath, Sundar [Department of Medicine Division of Hematology and Oncology, Icahn School of Medicine at Mount Sinai, New York, NY (United States); Kostakoglu, Lale, E-mail: lale.kostakoglu@mssm.edu [Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY (United States)

    2014-12-15

    Highlights: • Metabolic changes on FDG PET/CT offer an earlier response evaluation than MRI. • PET/CT is less sensitive than MRI for diffuse bone marrow involvement. • PET/CT is a highly sensitive modality to determine extra-medullary disease. • Red marrow expansion: false positive findings on both FDG PET/CT and MRI. • Compression fractures are best characterized with MRI. - Abstract: 18-Flurodeoxyglucose Positron Emission Tomography with computed tomography (FDG PET/CT) and Magnetic Resonance Imaging (MRI) have higher sensitivity and specificity than whole-body X-ray (WBXR) survey in evaluating disease extent in patients with multiple myeloma (MM). Both modalities are now recommended by the Durie–Salmon Plus classification although the emphasis is more on MRI than PET/CT. The presence of extra-medullary disease (EMD) as evaluated by PET/CT imaging, initial SUV{sub max} and number of focal lesions (FL) are deemed to be strong prognostic parameters at staging. MRI remains the most sensitive technique for the detection of diffuse bone marrow involvement in both the pre and post-therapy setting. Compression fractures are best characterized with MRI signal changes, for determining vertebroplasty candidates. While PET/CT allows for earlier and more specific evaluation of therapeutic efficacy compared to MRI, when signal abnormalities persist years after treatment. PET/CT interpretation, however, can be challenging in the vertebral column and pelvis as well as in cases with post-therapy changes. Hence, a reading approach combining the high sensitivity of MRI and superior specificity of FDG PET/CT would be preferred to increase the diagnostic accuracy. In summary, the established management methods in MM, mainly relying on biological tumor parameters should be complemented with functional imaging data, both at staging and restaging for optimal management of MM.

  12. Cherenkov light imaging tests with state-of-the-art solid state photon counter for the CLAS12 RICH detector

    Science.gov (United States)

    Balossino, Ilaria; Barion, L.; Contalbrigo, M.; Lenisa, P.; Lucherini, V.; Malaguti, R.; Mirazita, M.; Movsisyan, A.; Squerzanti, S.; Turisini, M.

    2017-12-01

    A large area ring-imaging Cherenkov detector will be operated for hadron identification in the 3 GeV / c to 8 GeV / c momentum range at the CLAS12 experiment at the upgraded continuous electron beam accelerator facility of Jefferson Lab. The detector, consisting of aerogel radiator, composite mirrors and photon counters, will be built with a hybrid optics design to allow the detection of Cherenkov light for both forward and large angle hadron tracks. The active area has to be densely packed and highly segmented, covering about 1m2 with pixels of 6mm2 , and to allow a time resolution of 1 ns. A technology that can offer a cost-effective solution and low material budget could be Silicon Photomultipliers (SiPM) thanks to their high gain at low bias voltage, fast timing, good single-photoelectron resolution and insensitivity to magnetic fields. An investigation is ongoing on samples of 3 × 3mm2 SiPM of different micro-cell size to assess the single photon detection capability in the presence of high dark count rate due to thermal generation effects, after-pulses or optical cross-talk and to study the response to the moderate radiation damage expected at CLAS12. In this work, a brief review of the latest and most interesting results from these studies will be shown.

  13. Towards Optimal Power Management of Hybrid Electric Vehicles in Real-Time: A Review on Methods, Challenges, and State-Of-The-Art Solutions

    Directory of Open Access Journals (Sweden)

    Ahmed M. Ali

    2018-02-01

    Full Text Available In light of increasing alerts about limited energy sources and environment degradation, it has become essential to search for alternatives to thermal engine-based vehicles which are a major source of air pollution and fossil fuel depletion. Hybrid electric vehicles (HEVs, encompassing multiple energy sources, are a short-term solution that meets the performance requirements and contributes to fuel saving and emission reduction aims. Power management methods such as regulating efficient energy flow to the vehicle propulsion, are core technologies of HEVs. Intelligent power management methods, capable of acquiring optimal power handling, accommodating system inaccuracies, and suiting real-time applications can significantly improve the powertrain efficiency at different operating conditions. Rule-based methods are simply structured and easily implementable in real-time; however, a limited optimality in power handling decisions can be achieved. Optimization-based methods are more capable of achieving this optimality at the price of augmented computational load. In the last few years, these optimization-based methods have been under development to suit real-time application using more predictive, recognitive, and artificial intelligence tools. This paper presents a review-based discussion about these new trends in real-time optimal power management methods. More focus is given to the adaptation tools used to boost methods optimality in real-time. The contribution of this work can be identified in two points: First, to provide researchers and scholars with an overview of different power management methods. Second, to point out the state-of-the-art trends in real-time optimal methods and to highlight promising approaches for future development.

  14. State-of-the-art

    DEFF Research Database (Denmark)

    Pecher, Arthur; Kofoed, Jens Peter

    This report presents a short overview on the state-of-the-art of wave tank testing of wave energy converters (WEC). Here for, it focuses mainly on the Phase 1 and 2 development phases of wave energy converters, as these are done in the wave tank (WEC), while the other development phases are perfo......This report presents a short overview on the state-of-the-art of wave tank testing of wave energy converters (WEC). Here for, it focuses mainly on the Phase 1 and 2 development phases of wave energy converters, as these are done in the wave tank (WEC), while the other development phases...

  15. Advances in Bio-Imaging From Physics to Signal Understanding Issues State-of-the-Art and Challenges

    CERN Document Server

    Racoceanu, Daniel; Gouaillard, Alexandre

    2012-01-01

    Advances in Imaging Devices and Image processing stem from cross-fertilization between many fields of research such as Chemistry, Physics, Mathematics and Computer Sciences. This BioImaging Community feel the urge to integrate more intensively its various results, discoveries and innovation into ready to use tools that can address all the new exciting challenges that Life Scientists (Biologists, Medical doctors, ...) keep providing, almost on a daily basis. Devising innovative chemical probes, for example, is an archetypal goal in which image quality improvement must be driven by the physics of acquisition, the image processing and analysis algorithms and the chemical skills in order to design an optimal bioprobe. This book offers an overview of the current advances in many research fields related to bioimaging and highlights the current limitations that would need to be addressed in the next decade to design fully integrated BioImaging Device.

  16. Hepatocellular adenoma: findings at state-of-the-art magnetic resonance imaging, ultrasound, computed tomography and pathologic analysis

    International Nuclear Information System (INIS)

    Hussain, Shahid M.; Bos, Indra C. van den; Dwarkasing, Roy S.; Kuiper, Jan-Willem; Hollander, Jan den

    2006-01-01

    The purpose of this paper is to describe the most recent concepts and pertinent findings of hepatocellular adenomas, including clinical presentation, gross pathology and histology, pathogenesis and transformation into hepatocellular carcinoma (HCC), and imaging findings at ultrasound (US), computed tomography (CT), and magnetic resonance (MR) imaging. (orig.)

  17. Performance Evaluation of State-of-the-Art Local Feature Detectors and Descriptors in the Context of Longitudinal Registration of Retinal Images.

    Science.gov (United States)

    Saha, Sajib K; Xiao, Di; Frost, Shaun; Kanagasingam, Yogesan

    2018-02-17

    In this paper we systematically evaluate the performance of several state-of-the-art local feature detectors and descriptors in the context of longitudinal registration of retinal images. Longitudinal (temporal) registration facilitates to track the changes in the retina that has happened over time. A wide number of local feature detectors and descriptors exist and many of them have already applied for retinal image registration, however, no comparative evaluation has been made so far to analyse their respective performance. In this manuscript we evaluate the performance of the widely known and commonly used detectors such as Harris, SIFT, SURF, BRISK, and bifurcation and cross-over points. As of descriptors SIFT, SURF, ALOHA, BRIEF, BRISK and PIIFD are used. Longitudinal retinal image datasets containing a total of 244 images are used for the experiment. The evaluation reveals some potential findings including more robustness of SURF and SIFT keypoints than the commonly used bifurcation and cross-over points, when detected on the vessels. SIFT keypoints can be detected with a reliability of 59% for without pathology images and 45% for with pathology images. For SURF keypoints these values are respectively 58% and 47%. ALOHA descriptor is best suited to describe SURF keypoints, which ensures an overall matching accuracy, distinguishability of 83%, 93% and 78%, 83% for without pathology and with pathology images respectively.

  18. Evaluation of state-of-the-art segmentation algorithms for left ventricle infarct from late Gadolinium enhancement MR images.

    Science.gov (United States)

    Karim, Rashed; Bhagirath, Pranav; Claus, Piet; James Housden, R; Chen, Zhong; Karimaghaloo, Zahra; Sohn, Hyon-Mok; Lara Rodríguez, Laura; Vera, Sergio; Albà, Xènia; Hennemuth, Anja; Peitgen, Heinz-Otto; Arbel, Tal; Gonzàlez Ballester, Miguel A; Frangi, Alejandro F; Götte, Marco; Razavi, Reza; Schaeffter, Tobias; Rhode, Kawal

    2016-05-01

    Studies have demonstrated the feasibility of late Gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) imaging for guiding the management of patients with sequelae to myocardial infarction, such as ventricular tachycardia and heart failure. Clinical implementation of these developments necessitates a reproducible and reliable segmentation of the infarcted regions. It is challenging to compare new algorithms for infarct segmentation in the left ventricle (LV) with existing algorithms. Benchmarking datasets with evaluation strategies are much needed to facilitate comparison. This manuscript presents a benchmarking evaluation framework for future algorithms that segment infarct from LGE CMR of the LV. The image database consists of 30 LGE CMR images of both humans and pigs that were acquired from two separate imaging centres. A consensus ground truth was obtained for all data using maximum likelihood estimation. Six widely-used fixed-thresholding methods and five recently developed algorithms are tested on the benchmarking framework. Results demonstrate that the algorithms have better overlap with the consensus ground truth than most of the n-SD fixed-thresholding methods, with the exception of the Full-Width-at-Half-Maximum (FWHM) fixed-thresholding method. Some of the pitfalls of fixed thresholding methods are demonstrated in this work. The benchmarking evaluation framework, which is a contribution of this work, can be used to test and benchmark future algorithms that detect and quantify infarct in LGE CMR images of the LV. The datasets, ground truth and evaluation code have been made publicly available through the website: https://www.cardiacatlas.org/web/guest/challenges. Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.

  19. State-of-The-Art and Applications of 3D Imaging Sensors in Industry, Cultural Heritage, Medicine, and Criminal Investigation.

    Science.gov (United States)

    Sansoni, Giovanna; Trebeschi, Marco; Docchio, Franco

    2009-01-01

    3D imaging sensors for the acquisition of three dimensional (3D) shapes have created, in recent years, a considerable degree of interest for a number of applications. The miniaturization and integration of the optical and electronic components used to build them have played a crucial role in the achievement of compactness, robustness and flexibility of the sensors. Today, several 3D sensors are available on the market, even in combination with other sensors in a "sensor fusion" approach. An importance equal to that of physical miniaturization has the portability of the measurements, via suitable interfaces, into software environments designed for their elaboration, e.g., CAD-CAM systems, virtual renders, and rapid prototyping tools. In this paper, following an overview of the state-of-art of 3D imaging sensors, a number of significant examples of their use are presented, with particular reference to industry, heritage, medicine, and criminal investigation applications.

  20. State-of-The-Art and Applications of 3D Imaging Sensors in Industry, Cultural Heritage, Medicine, and Criminal Investigation

    Directory of Open Access Journals (Sweden)

    Giovanna Sansoni

    2009-01-01

    Full Text Available 3D imaging sensors for the acquisition of three dimensional (3D shapes have created, in recent years, a considerable degree of interest for a number of applications. The miniaturization and integration of the optical and electronic components used to build them have played a crucial role in the achievement of compactness, robustness and flexibility of the sensors. Today, several 3D sensors are available on the market, even in combination with other sensors in a “sensor fusion” approach. An importance equal to that of physical miniaturization has the portability of the measurements, via suitable interfaces, into software environments designed for their elaboration, e.g., CAD-CAM systems, virtual renders, and rapid prototyping tools. In this paper, following an overview of the state-of-art of 3D imaging sensors, a number of significant examples of their use are presented, with particular reference to industry, heritage, medicine, and criminal investigation applications.

  1. State-of-the-Art Review of Echocardiographic Imaging in the Evaluation and Treatment of Functional Tricuspid Regurgitation.

    Science.gov (United States)

    Hahn, Rebecca T

    2016-12-01

    Functional or secondary tricuspid regurgitation (TR) is the most common cause of severe TR in the Western world. The presence of functional TR, either isolated or in combination with left heart disease, is associated with unfavorable natural history. Surgical mortality for isolated tricuspid valve interventions remains higher than for any other single valve surgery, and surgical options for repair do not have consistent long-term durability. In addition, as more patients undergo transcatheter left valve interventions, developing transcatheter solutions for functional TR has gained greater momentum. Numerous transcatheter devices are currently in early clinical trials. All patients require an assessment of valve morphology and function, and transcatheter devices typically require intraprocedural guidance by echocardiography. The following review will describe tricuspid anatomy, define echocardiographic views for evaluating tricuspid valve morphology and function, and discuss imaging requirements for the current transcatheter devices under development for the treatment of functional TR. © 2016 American Heart Association, Inc.

  2. State-of-the-art HR-US imaging findings of the most frequent musculoskeletal soft-tissue tumors

    International Nuclear Information System (INIS)

    Widmann, Gerlig; Riedl, Andreas; Schoepf, Daniel; Glodny, Bernhard; Peer, Siegfried; Gruber, Hannes

    2009-01-01

    High resolution ultrasound (HR-US) including color Doppler ultrasound (CD-US), power Doppler ultrasound (PD-US), and spectral wave analysis (SWA), is a broadly available, non-invasive and relatively low-cost modality without ionizing radiation. It is increasingly used for initial assessment of an ambiguous musculoskeletal soft-tissue lesion and for sonographically guided core biopsy. The aim of this review is to provide sonographic findings of the most frequent benign and malign soft-tissue lesions. By this essay, we can show that combined with clinical features, with information on tumor-localization and patient age, many musculoskeletal lesions may be successfully characterized by HR-US. In contrast, a mere morphologic assignment of some fibrous tumors and malignant lesions remains often impossible; however, certain CD-US signs such as anarchic vascular architecture or arteriovenous shunting may be very helpful indicators for malignancy. HR-US offers a simple, quick, and reliable first-line examination of musculoskeletal soft-tissue lesions and may have an important role in the diagnostic work-up followed by magnetic resonance or multimodality imaging and guided core biopsy. (orig.)

  3. State of the art in advanced endoscopic imaging for the detection and evaluation of dysplasia and early cancer of the gastrointestinal tract

    Directory of Open Access Journals (Sweden)

    Coda S

    2014-05-01

    Full Text Available Sergio Coda,1,2 Andrew V Thillainayagam1,2 1Section of Gastroenterology and Hepatology, Department of Medicine and Photonics Group, Department of Physics, Imperial College London, London, UK; 2Endoscopy Unit, Charing Cross Hospital, Imperial College Healthcare NHS Trust, London, UK Abstract: Ideally, endoscopists should be able to detect, characterize, and confirm the nature of a lesion at the bedside, minimizing uncertainties and targeting biopsies and resections only where necessary. However, under conventional white-light inspection – at present, the sole established technique available to most of humanity – premalignant conditions and early cancers can frequently escape detection. In recent years, a range of innovative techniques have entered the endoscopic arena due to their ability to enhance the contrast of diseased tissue regions beyond what is inherently possible with standard white-light endoscopy equipment. The aim of this review is to provide an overview of the state-of-the-art advanced endoscopic imaging techniques available for clinical use that are impacting the way precancerous and neoplastic lesions of the gastrointestinal tract are currently detected and characterized at endoscopy. The basic instrumentation and the physics behind each method, followed by the most influential clinical experience, are described. High-definition endoscopy, with or without optical magnification, has contributed to higher detection rates compared with white-light endoscopy alone and has now replaced ordinary equipment in daily practice. Contrast-enhancement techniques, whether dye-based or computed, have been combined with white-light endoscopy to further improve its accuracy, but histology is still required to clarify the diagnosis. Optical microscopy techniques such as confocal laser endomicroscopy and endocytoscopy enable in vivo histology during endoscopy; however, although of invaluable assistance for tissue characterization, they have not

  4. Digital Breast Tomosynthesis: State of the Art

    Science.gov (United States)

    Vedantham, Srinivasan; Vijayaraghavan, Gopal R.; Kopans, Daniel B.

    2015-01-01

    This topical review on digital breast tomosynthesis (DBT) is provided with the intent of describing the state of the art in terms of technology, results from recent clinical studies, advanced applications, and ongoing efforts to develop multimodality imaging systems that include DBT. Particular emphasis is placed on clinical studies. The observations of increase in cancer detection rates, particularly for invasive cancers, and the reduction in false-positive rates with DBT in prospective trials indicate its benefit for breast cancer screening. Retrospective multireader multicase studies show either noninferiority or superiority of DBT compared with mammography. Methods to curtail radiation dose are of importance. © RSNA, 2015 PMID:26599926

  5. Automatic skull segmentation from MR images for realistic volume conductor models of the head: Assessment of the state-of-the-art.

    Science.gov (United States)

    Nielsen, Jesper D; Madsen, Kristoffer H; Puonti, Oula; Siebner, Hartwig R; Bauer, Christian; Madsen, Camilla Gøbel; Saturnino, Guilherme B; Thielscher, Axel

    2018-03-12

    Anatomically realistic volume conductor models of the human head are important for accurate forward modeling of the electric field during transcranial brain stimulation (TBS), electro- (EEG) and magnetoencephalography (MEG). In particular, the skull compartment exerts a strong influence on the field distribution due to its low conductivity, suggesting the need to represent its geometry accurately. However, automatic skull reconstruction from structural magnetic resonance (MR) images is difficult, as compact bone has a very low signal in magnetic resonance imaging (MRI). Here, we evaluate three methods for skull segmentation, namely FSL BET2, the unified segmentation routine of SPM12 with extended spatial tissue priors, and the skullfinder tool of BrainSuite. To our knowledge, this study is the first to rigorously assess the accuracy of these state-of-the-art tools by comparison with CT-based skull segmentations on a group of ten subjects. We demonstrate several key factors that improve the segmentation quality, including the use of multi-contrast MRI data, the optimization of the MR sequences and the adaptation of the parameters of the segmentation methods. We conclude that FSL and SPM12 achieve better skull segmentations than BrainSuite. The former methods obtain reasonable results for the upper part of the skull when a combination of T1- and T2-weighted images is used as input. The SPM12-based results can be improved slightly further by means of simple morphological operations to fix local defects. In contrast to FSL BET2, the SPM12-based segmentation with extended spatial tissue priors and the BrainSuite-based segmentation provide coarse reconstructions of the vertebrae, enabling the construction of volume conductor models that include the neck. We exemplarily demonstrate that the extended models enable a more accurate estimation of the electric field distribution during transcranial direct current stimulation (tDCS) for montages that involve extraencephalic

  6. Digital astrophotography the state of the art

    CERN Document Server

    Ratledge, David

    2005-01-01

    The CCD (Charge-Coupled Device) has revolutionised optical astronomy during the past 20 years, and specialised astronomical CCD cameras are now even more affordable, colour is standard, and they provide spectacular results. "Digital Astrophotography: The State of the Art", provides some examples of the best images, and gives readers hints and tips about how to get the best out of this extraordinary technology. Experts in CCD astronomy from North America and Europe have contributed to this book, illustrating their help and advice with many beautiful colour images - the book is in full colour throughout. Techniques range from using simple webcams to highly technical aspects such as supernovae patrolling. Computer processing, stacking and image-enhancement are detailed, along with many hints and tips from the experts.

  7. State of the art in video system performance

    Science.gov (United States)

    Lewis, Michael J.

    1990-01-01

    The closed circuit television (CCTV) system that is onboard the Space Shuttle has the following capabilities: camera, video signal switching and routing unit (VSU); and Space Shuttle video tape recorder. However, this system is inadequate for use with many experiments that require video imaging. In order to assess the state-of-the-art in video technology and data storage systems, a survey was conducted of the High Resolution, High Frame Rate Video Technology (HHVT) products. The performance of the state-of-the-art solid state cameras and image sensors, video recording systems, data transmission devices, and data storage systems versus users' requirements are shown graphically.

  8. State of the art in semiconductor detectors

    International Nuclear Information System (INIS)

    Rehak, P.; Gatti, E.

    1990-01-01

    The state of the art in semiconductor detectors for elementary particle physics and X-ray astronomy is briefly reviewed. Semiconductor detectors are divided into two groups; i) classical semiconductor diode detectors and ii) semiconductor memory detectors. Principles of signal formation for both groups of detectors are described and their performance is compared. New developments of silicon detectors are reported here. (orig.)

  9. State of the art in semiconductor detectors

    International Nuclear Information System (INIS)

    Rehak, P.; Gatti, E.

    1989-01-01

    The state of the art in semiconductor detectors for elementary particle physics and x-ray astronomy is briefly reviewed. Semiconductor detectors are divided into two groups; classical semiconductor diode detectors; and semiconductor memory detectors. Principles of signal formation for both groups of detectors are described and their performance is compared. New developments of silicon detectors are reported here. 13 refs., 8 figs

  10. State of the art in microfabrication

    NARCIS (Netherlands)

    Schmitz, Jurriaan

    2014-01-01

    In this review paper the state of the art in microfabrication is presented. The focus is on trends in integrated circuit fabrication by mainstream industrial players. The article starts with Moore’s Law, describing its inception as well as the evolution of Moore’s metric of the number of components

  11. Meniscal Allograft Transplantation: State of the Art.

    Science.gov (United States)

    Trentacosta, Natasha; Graham, William C; Gersoff, Wayne K

    2016-06-01

    Meniscal allograft transplantation has evolved over the years to provide a state-of-the-art technique for the sports medicine surgeon to utilize in preserving contact mechanics and function of the knee in irreparable meniscal pathology. However, this procedure continues to spark considerable debate on proper tissue processing techniques, acceptable indications, methods of implantation, and potential long-term outcomes.

  12. Multimodal Dialogue Management - State of the art

    NARCIS (Netherlands)

    Bui Huu Trung, B.H.T.

    This report is about the state of the art in dialogue management. We first introduce an overview of a multimodal dialogue system and its components. Second, four main approaches to dialogue management are described (finite-state and frame-based, information-state based and probabilistic, plan-based,

  13. Platelet kinetics: the state of the art

    International Nuclear Information System (INIS)

    Heyns, A. duP

    1984-01-01

    In this paper an overview of the state of the art of platelet kinetics 1982 is presented. The subjects considered include a discussion of the advantages and disadvantages of some of the many radionuclide platelet labels, viz 51 Cr, 111 In, focussing briefly on models for analysis of platelets survival. (Auth.)

  14. State-of-the-art inventory

    NARCIS (Netherlands)

    Verhagen, H.J.; Van Gerven, K.A.J.; Akkerman, G.J.

    2005-01-01

    The present report provides a state-of-the-art inventory of relevant information and technical concepts for the ComCoast project, being the first phase of the research stages of Work Package 3 (WP3). This project was assigned to Royal Haskoning by CUR. The information scan was set-up in a systematic

  15. Evaluation of state-of-the-art imaging systems for in vivo monitoring of retinal structure in mice: current capabilities and limitations

    Science.gov (United States)

    Zhang, Pengfei; Zam, Azhar; Pugh, Edward N.; Zawadzki, Robert J.

    2014-02-01

    Animal models of human diseases play an important role in studying and advancing our understanding of these conditions, allowing molecular level studies of pathogenesis as well as testing of new therapies. Recently several non-invasive imaging modalities including Fundus Camera, Scanning Laser Ophthalmoscopy (SLO) and Optical Coherence Tomography (OCT) have been successfully applied to monitor changes in the retinas of the living animals in experiments in which a single animal is followed over a portion of its lifespan. Here we evaluate the capabilities and limitations of these three imaging modalities for visualization of specific structures in the mouse eye. Example images acquired from different types of mice are presented. Future directions of development for these instruments and potential advantages of multi-modal imaging systems are discussed as well.

  16. A State of the Art Overview

    DEFF Research Database (Denmark)

    Jahangiri, Tohid; Bak, Claus Leth; Silva, Filipe Miguel Faria da

    2015-01-01

    The first EHV composite cross-arms have been used since late 1990's in Switzerland. It was the first step to the compaction of towers sizes. Since then, significant advances have been made in composite cross-arms technology while the lattice construction technique has not been seriously challenged...... of EHV composite cross-arms and lightning protection methods are reviewed based on the state of the art review and subsequently some solutions are presented to overcome the two main challenges....

  17. Diagnostic performance of state-of-the-art imaging techniques for morphological assessment of vascular abnormalities in patients with chronic thromboembolic pulmonary hypertension (CTEPH)

    Energy Technology Data Exchange (ETDEWEB)

    Ley, Sebastian [University Hospital Heidelberg, Department of Diagnostic and Interventional Radiology, Heidelberg (Germany); Ley-Zaporozhan, Julia [University Hospital Heidelberg, Department of Diagnostic and Interventional Radiology, Heidelberg (Germany); Johannes Gutenberg University, Department of Diagnostic and Interventional Radiology; Universitaetsmedizin, Mainz (Germany); Pitton, Michael B.; Schneider, Jens; Wirth, Gesine M.; Dueber, Christoph; Kreitner, Karl-Friedrich [Johannes Gutenberg University, Department of Diagnostic and Interventional Radiology; Universitaetsmedizin, Mainz (Germany); Mayer, Eckhard [Kerckhoff-Hospital Bad Nauheim, Department of Thoracic Surgery, Bad Nauheim (Germany)

    2012-03-15

    To determine the most comprehensive imaging technique for the assessment of pulmonary arteries in patients with chronic thromboembolic pulmonary hypertension (CTEPH). 24 patients with CTEPH were examined by ECG-gated multi-detector CT angiography (MD-CTA), contrast-enhanced MR angiography (ce-MRA) and selective digital subtraction angiography (DSA) within 3 days. Two readers in consensus separately evaluated each imaging technique (48 main, 144 lobar and 449 segmental arteries) for typical changes like complete obstructions, vessel cut-offs, intimal irregularities, incorporated thrombus formations, and bands and webs. A joint interpretation of all three techniques served as a reference standard. Based on image quality, there was no non-diagnostic examination by either imaging technique. DSA did not sufficiently display 1 main, 3 lobar and 4 segmental arteries. The pulmonary trunk was not assessable by DSA. One patient showed thrombotic material at this level only by MD-CTA and MRA. Sensitivity and specificity of MD-CTA regarding CTEPH-related changes at the main/lobar and at the segmental levels were 100%/100% and 100%/99%, of ce-MRA 83.1%/98.6% and 87.7%/98.1%, and of DSA 65.7%/100% and 75.8%/100%, respectively. ECG-gated MD-CTA proved the most adequate technique for assessment of the pulmonary arteries in the diagnostic work-up of CTEPH patients. (orig.)

  18. Time-of-flight method for positron tomographic imaging and state-of-the-art of detector technology for emission tomography

    International Nuclear Information System (INIS)

    Allemand, R.; Campagnolo, R.; Garderet, P.; Gariod, R.; Laval, M.; Moszynski, M.; Tournier, E.; Vacher, J.

    1981-10-01

    Positron imaging is essentially a method for studying dynamic phenomena and positron emitters are characterized by a short life which allows to inject a high activity. This means that a high counting-rate capability is a major feature of a P.C.T.; furthermore a high resolving time permits to reduce the random coincidence events which yield a low spatial frequency back-ground reducing the contrast of the image and introducing an error for quantitative measurements. For these points of view, CsF appears to be the most suitable scintillator. Its fast light emission allows to reach a time-of-flight information which improves the signal to noise ratio of the image. That advantage is a function of the object size and of the T.O.F. accuracy. Now, a 500 psec time resolution (FWHM) seems to be a realistic characteristics for an operational machine. The comparison between the conventional method and the T.O.F. technique has been expressed in terms of sensitivity gain which is the ratio of the number of events needed to obtain the same signal to noise ratio. A sensitivity gain of 4 has been theoretically estimated with a 500 psec timing and for a 450 mm diameter phantom. This evaluation seems to be in a good ageement with the first experimental results

  19. The analytical calibration in (bio)imaging/mapping of the metallic elements in biological samples--definitions, nomenclature and strategies: state of the art.

    Science.gov (United States)

    Jurowski, Kamil; Buszewski, Bogusław; Piekoszewski, Wojciech

    2015-01-01

    Nowadays, studies related to the distribution of metallic elements in biological samples are one of the most important issues. There are many articles dedicated to specific analytical atomic spectrometry techniques used for mapping/(bio)imaging the metallic elements in various kinds of biological samples. However, in such literature, there is a lack of articles dedicated to reviewing calibration strategies, and their problems, nomenclature, definitions, ways and methods used to obtain quantitative distribution maps. The aim of this article was to characterize the analytical calibration in the (bio)imaging/mapping of the metallic elements in biological samples including (1) nomenclature; (2) definitions, and (3) selected and sophisticated, examples of calibration strategies with analytical calibration procedures applied in the different analytical methods currently used to study an element's distribution in biological samples/materials such as LA ICP-MS, SIMS, EDS, XRF and others. The main emphasis was placed on the procedures and methodology of the analytical calibration strategy. Additionally, the aim of this work is to systematize the nomenclature for the calibration terms: analytical calibration, analytical calibration method, analytical calibration procedure and analytical calibration strategy. The authors also want to popularize the division of calibration methods that are different than those hitherto used. This article is the first work in literature that refers to and emphasizes many different and complex aspects of analytical calibration problems in studies related to (bio)imaging/mapping metallic elements in different kinds of biological samples. Copyright © 2014 Elsevier B.V. All rights reserved.

  20. Where is your state of the art?

    Science.gov (United States)

    Ríos Gaona, Manuel

    2015-04-01

    Beyond the purposes of publishing, questioning and/or hypothesizing, every research has the noble aim to quench the constant human need of pushing farther away the boundaries of knowledge, may such frontier exist. The state of the art is the generic expression coined to limit the whereabouts of any particular knowledge. We use it just like a compass, it tells us how far we are, what has been done and where we should go. Take for instance quantum field theory, the state of the art in particle physics will tell you that everything that exists in this universe is made of bosons, quarks and leptons. What!?. Hold on, I was taught (and luckily maybe you weren't) that the fundamental particles were electrons, neutrons and protons, right?. Indeed, that is the state of the art but from almost one century ago. So, if I may ask... where is your state of the art? This is not about quantum physics; it is not even about hydrology; it is about everything. Today, everybody doing or not a PhD fiercely believes that their research is important, extremely unique, life changing (and help us God if we are wrong); but how can you be so sure that what you do, isn't already done?. We live in a modern world, cool environmental scientists now have tagged this era as the Anthropocene; globalization is everywhere and of course knowledge has not escaped to it. Not only knowledge is now global but is totally diversified, any crazy idea you can think of (or actually you can't) it is very likely that somebody already has his/hers hands on it. Nevertheless, this is a good thing, isn't it?. Well, that is the whole point. Every time I should write my research's state of the art, I always get overwhelmed because it actually is pretty difficult to establish, and later when I think I get it, it seems that I am solving issues that somebody already bothered to solve 30 years ago. Therefore, does it really have some purpose to be swimming in a huge pool of knowledge, not knowing where exactly I am? or

  1. A state-of-the-art pipeline for postmortem CT and MRI visualization: from data acquisition to interactive image interpretation at autopsy

    Energy Technology Data Exchange (ETDEWEB)

    Persson, Anders (Center for Medical Image Science and Visualization (CMIV), Univ. of Linkoeping, Linkoeping (Sweden); Dept. of Radiology of Medical and Health Sciences (IMH), Linkoeping Univ. Hospital, Linkoeping (Sweden)), email: anders.persson@cmiv.liu.se; Lindblom, Maria (Dept. of Radiology of Medical and Health Sciences (IMH), Linkoeping Univ. Hospital, Linkoeping (Sweden)); Jackowski, Christian (Inst. of Legal Medicine, Univ. of Zurich, Zurich (Switzerland))

    2011-06-15

    The importance of autopsy procedures leading to the establishment of the cause of death is well-known. A recent addition to the autopsy work flow is the possibility of conducting postmortem imaging, in its 3D version also called virtual autopsy (VA), using multidetector computed tomography (MDCT) or magnetic resonance imagining (MRI) data from scans of cadavers displayed with direct volume rendering (DVR) 3D techniques. The use of the data and their workflow are presented. Data acquisition was performed and high quality data-sets with submillimeter precision were acquired. New data acquisition techniques such as dual-energy CT (DECT) and quantitative MRI, then were implemented and provided additional information. Particular findings hardly visualized in conventional autopsy can rather easy be seen at the full body CT, such as air distribution, e.g. pneumothorax, pneumopericardium, air embolism, and wound channels. MRI shows natural deaths such as myocardial infarctions. Interactive visualization of these 3D data-sets can provide valuable insight into the corpses and enables non-invasive diagnostic procedures. In postmortem CT imaging, not being limited by a patient depending radiation dose limit the data-sets can, however, be generated with such a high resolution that they become difficult to handle in today's archive retrieval and interactive visualization systems, specifically in the case of full body scans. To take full advantage of these new technologies the postmortem workflow needs to be tailored to the demands and opportunities that the new technologies allow

  2. A state-of-the-art pipeline for postmortem CT and MRI visualization: from data acquisition to interactive image interpretation at autopsy

    International Nuclear Information System (INIS)

    Persson, Anders; Lindblom, Maria; Jackowski, Christian

    2011-01-01

    The importance of autopsy procedures leading to the establishment of the cause of death is well-known. A recent addition to the autopsy work flow is the possibility of conducting postmortem imaging, in its 3D version also called virtual autopsy (VA), using multidetector computed tomography (MDCT) or magnetic resonance imagining (MRI) data from scans of cadavers displayed with direct volume rendering (DVR) 3D techniques. The use of the data and their workflow are presented. Data acquisition was performed and high quality data-sets with submillimeter precision were acquired. New data acquisition techniques such as dual-energy CT (DECT) and quantitative MRI, then were implemented and provided additional information. Particular findings hardly visualized in conventional autopsy can rather easy be seen at the full body CT, such as air distribution, e.g. pneumothorax, pneumopericardium, air embolism, and wound channels. MRI shows natural deaths such as myocardial infarctions. Interactive visualization of these 3D data-sets can provide valuable insight into the corpses and enables non-invasive diagnostic procedures. In postmortem CT imaging, not being limited by a patient depending radiation dose limit the data-sets can, however, be generated with such a high resolution that they become difficult to handle in today's archive retrieval and interactive visualization systems, specifically in the case of full body scans. To take full advantage of these new technologies the postmortem workflow needs to be tailored to the demands and opportunities that the new technologies allow

  3. State of the art in cosmology

    International Nuclear Information System (INIS)

    Zel'dovich, Ya.B.

    1983-01-01

    The present state of the art in cosmology is under discussion. The general picture of the Universe evolution is presented, and its main stages are outlined. The prooess of formation of the large scale Universe structure is considered. The possibility of investigation into the ''inflation'' period of the ''very-very early Universe'' from the view point of theoretical physics is sown. It is noted that cosmology will become a complete science only when physics gives an exhaustive answer to all issues raised by cosmology

  4. Analyst workbenches state of the art report

    CERN Document Server

    Rock-Evans, R

    1987-01-01

    Analyst Workbenches examines various aspects of analyst workbenches and the tasks and data that they should support. The major advances and state of the art in analyst workbenches are discussed. A comprehensive list of the available analyst workbenches, both the experimental and the commercial products, is provided. Comprised of three parts, this book begins by describing International Computers Ltd's approach to automating analysis and design. It then explains what business analysis really means, outlines the principal features of analyst workbenches, and considers the ways in which they can

  5. Can independent coronal multiplanar reformatted images obtained using state-of-the-art MDCT scanners be used for primary interpretation of MDCT of the abdomen and pelvis? A feasibility study

    International Nuclear Information System (INIS)

    Sebastian, Sunit; Kalra, Mannudeep K.; Mittal, Pardeep; Saini, Sanjay; Small, William C.

    2007-01-01

    independent review of coronal reformats as compared with transverse images alone (p < 0.001). Readers' confidence was also found to be higher on coronal evaluations as compared to axial images (p < 0.01). There was good interobserver agreement between the two readers. Conclusion: Independent coronal multiplanar reformatted images obtained using state-of-the-art MDCT scanners show promise as the preferred orientation and can be useful for primary interpretation of MDCT of the abdomen and pelvis

  6. State of the art on bioethanol production

    International Nuclear Information System (INIS)

    Barisano, D.; De Bari, I.; Viola, E.; Zimbardi, F.; Braccio, G.; Cantarella, M.; Gallifuoco, A.

    2001-01-01

    The state of the art, deals with the ethanol production from current processes based on the use of sugar and starch as feedstock and those under development based on lignocellulosic biomass. In the first section are reported the commercially available processes together with hints to the newest technologies. As regard the ethanol production from lignocellulosics, it has been collected data on the biomass availability in Europe as energy crops, industrial crops, agricultural residues and domestic waste. It is provided a bibliographic study on the technologies and processes under development worldwide for the conversion of lignocellulosics into ethanol. Finally, a brief discussion on the economics highlights the near term viability of producing ethanol by this way [it

  7. Mechanical Ventilation: State of the Art.

    Science.gov (United States)

    Pham, Tài; Brochard, Laurent J; Slutsky, Arthur S

    2017-09-01

    Mechanical ventilation is the most used short-term life support technique worldwide and is applied daily for a diverse spectrum of indications, from scheduled surgical procedures to acute organ failure. This state-of-the-art review provides an update on the basic physiology of respiratory mechanics, the working principles, and the main ventilatory settings, as well as the potential complications of mechanical ventilation. Specific ventilatory approaches in particular situations such as acute respiratory distress syndrome and chronic obstructive pulmonary disease are detailed along with protective ventilation in patients with normal lungs. We also highlight recent data on patient-ventilator dyssynchrony, humidified high-flow oxygen through nasal cannula, extracorporeal life support, and the weaning phase. Finally, we discuss the future of mechanical ventilation, addressing avenues for improvement. Copyright © 2017 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.

  8. Digital multicolor printing: state of the art and future challenges

    Science.gov (United States)

    Kipphan, Helmut

    1995-04-01

    During the last 5 years, digital techniques have become extremely important in the graphic arts industry. All sections in the production flow for producing multicolor printed products - prepress, printing and postpress - are influenced by digitalization, in an evolutionary and revolutionary way. New equipment and network techniques bring all the sections closer together. The focus is put on high-quality multicolor printing, together with high productivity. Conventional offset printing technology is compared with the leading nonimpact printing technologies. Computer to press is contrasted with computer to print techniques. The newest available digital multicolor presses are described - the direct imaging offset printing press from HEIDELBERG with new laser imaging technique as well as the INDIGO and XEIKON presses based on electrophotography. Regarding technical specifications, economic calculations and print quality, it is worked out that each technique has its own market segments. An outlook is given for future computer to press techniques and the potential of nonimpact printing technologies for advanced high-speed multicolor computer to print equipment. Synergy effects from the NIP-technologies to the conventional printing technologies and vice versa are possible for building up innovative new products, for example hybrid printing systems. It is also shown that there is potential for improving the print quality, based on special screening algorithms, and a higher number of grey levels per pixel by using NIP-technologies. As an intermediate step in digitalization of the production flow, but also as an economical solution computer to plate equipment is described. By producing printed products totally in a digital way, digital color proofing as well as color management systems are needed. The newest high-tech equipment using NIP-technologies for producing proofs is explained. All in all it is shown that the state of the art in digital multicolor printing has reached

  9. Nuclear Liability, State of the Art

    International Nuclear Information System (INIS)

    Reitsma, S. M. S.

    2010-01-01

    Over fifty years ago states started to introduce legislation protecting the public against the potential magnitude and peculiarity of risks arising from the nuclear energy production. They did so trough a specific liability and compensation regime. Whether legislation was based on national initiatives or, as more frequently, related to international nuclear liability conventions, it was based on a number of principles being applied universally. Furthermore, it at the same time strived for not preventing the development of the nuclear industry because of an unbearable liability. This paper aims at explaining the broad outline of the above legislation, its development since its early years, the state of the art as regards its modernisation as well as the (alleged) problems underlying the delay in its introduction in a number of countries. When dealing with those problems it will be inevitable to touch upon a number of insurance related matters, which, as an insurer I am happy to tell, will lead me to familiar territory.(author).

  10. Entrepreneurship Education: State of the Art

    Directory of Open Access Journals (Sweden)

    José Carlos Sánchez García

    2017-10-01

    Full Text Available Job uncertainty and ambiguity is a reality in many current societies, therefore, the idea of self-employment has taken a more active role, not only out of necessity, but also because it brings innovation and development to societies. In view of this situation, the following question arises: how can we strengthen the entrepreneurial spirit of our students? This article has the objective to collect theoretical information of the state of the art on entrepreneurship education: what it has been, what it is, and what can it be, in order to present the current condition of the topic, both in the psychological and pedagogical field. To achieve this objective, information from 108 research sources, mainly from scientific articles and books was collected, concluding that, although generally, entrepreneurship education has significantly contributed to the creation of businesses, developing countries, specifically, those in Latin America, still require extra effort to fully implement entrepreneurship topic in the curriculums, particularly because of challenges such as political instability, technology and international competition.

  11. MRI Sequences in Head & Neck Radiology - State of the Art.

    Science.gov (United States)

    Widmann, Gerlig; Henninger, Benjamin; Kremser, Christian; Jaschke, Werner

    2017-05-01

    Background  Magnetic resonance imaging (MRI) has become an essential imaging modality for the evaluation of head & neck pathologies. However, the diagnostic power of MRI is strongly related to the appropriate selection and interpretation of imaging protocols and sequences. The aim of this article is to review state-of-the-art sequences for the clinical routine in head & neck MRI and to describe the evidence for which medical question these sequences and techniques are useful. Method  Literature review of state-of-the-art sequences in head & neck MRI. Results and Conclusion  Basic sequences (T1w, T2w, T1wC+) and fat suppression techniques (TIRM/STIR, Dixon, Spectral Fat sat) are important tools in the diagnostic workup of inflammation, congenital lesions and tumors including staging. Additional sequences (SSFP (CISS, FIESTA), SPACE, VISTA, 3D-FLAIR) are used for pathologies of the cranial nerves, labyrinth and evaluation of endolymphatic hydrops in Menière's disease. Vessel and perfusion sequences (3D-TOF, TWIST/TRICKS angiography, DCE) are used in vascular contact syndromes, vascular malformations and analysis of microvascular parameters of tissue perfusion. Diffusion-weighted imaging (EPI-DWI, non-EPI-DWI, RESOLVE) is helpful in cholesteatoma imaging, estimation of malignancy, and evaluation of treatment response and posttreatment recurrence in head & neck cancer. Understanding of MRI sequences and close collaboration with referring physicians improves the diagnostic confidence of MRI in the daily routine and drives further research in this fascinating image modality. Key Points:   · Understanding of MRI sequences is essential for the correct and reliable interpretation of MRI findings.. · MRI protocols have to be carefully selected based on relevant clinical information.. · Close collaboration with referring physicians improves the output obtained from the diagnostic possibilities of MRI.. Citation Format · Widmann G, Henninger B, Kremser C et

  12. Dual color chromogenic in situ hybridization for determination of HER2 status in breast cancer: a large comparative study to current state of the art fluorescence in situ hybridization

    Directory of Open Access Journals (Sweden)

    Mollerup Jens

    2012-02-01

    Full Text Available Abstract Background Chromogenic in situ hybridization (CISH is fast becoming a well established technique for easy and sensitive determination of HER2 gene status in breast cancer. However, for the chromogenic method to achieve status as a safe and reliable technique, the method needs to be validated against already known and validated FISH techniques. Methods Here it is reported from a comparative study where HER2 gene status obtained by HER2 CISH pharmDx™ Kit was compared to HER2 gene status obtained by the FDA approved HER2 FISH pharmDx™ Kit and the PathVysion HER-2 DNA probe Kit. The study included 365 formalin fixed and paraffin-embedded invasive breast cancer tissue specimens collected consecutively at a US reference laboratory. Results The data obtained revealed an overall HER2 status concordance of approximately 98% for comparisons of HER2 CISH pharmDx™ Kit to both HER2 FISH pharmDx™ Kit and PathVysion HER-2 DNA Probe Kit. Conclusions The concordance between results obtained using the recently FDA approved HER2 CISH pharmDx™ Kit with previously FDA approved FISH techniques for HER2 gene status determination indicate that the HER2 CISH pharmDx™ Kit is a reliable chromogenic alternative to fluorescence-based methods.

  13. Dual color chromogenic in situ hybridization for determination of HER2 status in breast cancer: a large comparative study to current state of the art fluorescence in situ hybridization

    Science.gov (United States)

    2012-01-01

    Background Chromogenic in situ hybridization (CISH) is fast becoming a well established technique for easy and sensitive determination of HER2 gene status in breast cancer. However, for the chromogenic method to achieve status as a safe and reliable technique, the method needs to be validated against already known and validated FISH techniques. Methods Here it is reported from a comparative study where HER2 gene status obtained by HER2 CISH pharmDx™ Kit was compared to HER2 gene status obtained by the FDA approved HER2 FISH pharmDx™ Kit and the PathVysion HER-2 DNA probe Kit. The study included 365 formalin fixed and paraffin-embedded invasive breast cancer tissue specimens collected consecutively at a US reference laboratory. Results The data obtained revealed an overall HER2 status concordance of approximately 98% for comparisons of HER2 CISH pharmDx™ Kit to both HER2 FISH pharmDx™ Kit and PathVysion HER-2 DNA Probe Kit. Conclusions The concordance between results obtained using the recently FDA approved HER2 CISH pharmDx™ Kit with previously FDA approved FISH techniques for HER2 gene status determination indicate that the HER2 CISH pharmDx™ Kit is a reliable chromogenic alternative to fluorescence-based methods. PMID:22333181

  14. Virtual microscopy and digital cytology: state of the art.

    Science.gov (United States)

    Giansanti, Daniele; Grigioni, Mauro; D'Avenio, Giuseppe; Morelli, Sandra; Maccioni, Giovanni; Bondi, Arrigo; Giovagnoli, Maria Rosaria

    2010-01-01

    The paper approaches a new technological scenario relevant for the introduction of the digital cytology (D-CYT) in the health service. A detailed analysis of the state of the art on the status of the introduction of D-CYT in the hospital and more in general in the dispersed territory has been conducted. The analysis was conducted in a form of review and was arranged into two parts: the first part focused on the technological tools needed to carry out a successful service (client server architectures, e-learning, quality assurance issues); the second part focused on issues oriented to help the introduction and evaluation of the technology (specific training in D-CYT, health technology assessment in-routine application, data format standards and picture archiving computerized systems (PACS) implementation, image quality assessment, strategies of navigation, 3D-virtual-reality potentialities). The work enlightens future scenarios of actions relevant for the introduction of the technology.

  15. Virtual microscopy and digital cytology: state of the art

    Directory of Open Access Journals (Sweden)

    Daniele Giansanti

    2010-06-01

    Full Text Available The paper approaches a new technological scenario relevant for the introduction of the digital cytology (D-CYT in the health service. A detailed analysis of the state of the art on the status of the introduction of D-CYT in the hospital and more in general in the dispersed territory has been conducted. The analysis was conducted in a form of review and was arranged into two parts: the first part focused on the technological tools needed to carry out a successful service (client server architectures, e-learning, quality assurance issues; the second part focused on issues oriented to help the introduction and evaluation of the technology (specific training in D-CYT, health technology assessment in-routine application, data format standards and picture archiving computerized systems (PACS implementation, image quality assessment, strategies of navigation, 3D-virtual-reality potentialities. The work enlightens future scenarios of actions relevant for the introduction of the technology.

  16. Greenhouse mechanization: State of the art and future perspective

    NARCIS (Netherlands)

    Henten, van E.

    2006-01-01

    This paper reviews the state of the art and future perspective of greenhouse mechanization. Driving forces for mechanization are identified. Dutch greenhouse crop production is used as an example. Analysis of a generic crop production process combined with a review of the state of the art in

  17. State of the Art in the Cramer Classification Scheme and ...

    Science.gov (United States)

    Slide presentation at the SOT FDA Colloquium on State of the Art in the Cramer Classification Scheme and Threshold of Toxicological Concern in College Park, MD. Slide presentation at the SOT FDA Colloquium on State of the Art in the Cramer Classification Scheme and Threshold of Toxicological Concern in College Park, MD.

  18. Digital radiography of the chest: state of the art

    International Nuclear Information System (INIS)

    Souto, M.; Malagari, K.S.; Tucker, D.; Tahoces, P.G.; Correa, J.; Benakis, V.S.; Roussos, C.; Strigaris, K.A.; Vidal, J.J.; Barnes, G.T.; Fraser, R.G.

    1994-01-01

    Digital image acquisition possesses a number of advantages over conventional systems in radiographic examination of the chest, the most important of which is its greater dynamic range. In addition, once digital images are acquired, they can be processed by computer in ways that cannot be rivalled by conventional analog techniques. Finally, digital images can be stored, retrieved and transmitted to local or remote sites. Here the status of the different digital systems employed in chest radiology and commonly used image processing techniques are reviewed. Also discussed are the current clinical applications of integrating digital chest radiography with a picture archiving and communication system (PACS) along with the difficulties typically encountered. Studies with a variety of digital techniques have been carried out on several fronts. Computed radiography based on photostimulable phosphor (CR) has replaced screen-film imaging in certain applications (i.e. bedside imaging). However, CR has limitations, namely its poor X-ray utilisation efficiency at high X-ray tube voltages and sensitivity to scatter; therefore, it is not ideal for all applications. Recently, a dedicated digital chest unit with excellent X-ray utilisation efficiency at high X-ray tube potentials has been introduced. On the basis of the state-of-the-art capabilities and research during the past decade, recommendations are made regarding the most desirable equipment specifications for dedicated and bedside digital chest radiography. (orig.)

  19. Cardiovascular nuclear medicine: state of the art

    International Nuclear Information System (INIS)

    Milcinski, M.

    1994-01-01

    Evaluation of myocardial function: first pass studies can be obtained at time of almost every investigation. Assessment of myocardial function is improved using short living isotopes and repeated stress studies as well as gated tomographic imaging and technetium perfusion agents. Nonimaging probes have limited value in continuous monitoring of cardiac function. Stress-echo (transoesophageal) is competitive to nuclear techniques in assessment of contractility. Myocardial perfusion imaging using knowledge from PET and available tomographic or planar imaging modalities gives unique possibilities to detect viable myocardium. Thallium remains the tracer for myocardial viability evaluation on convenient systems when new imaging protocols are applied. New technetium labeled radiopharmaceuticals allow better imaging possibilities for SPECT techniques. Several pharmacological agents are available in addition to traditional physical stress for assessing hemodynamic importance of coronary artery stenoses for diagnosis and in treatment evaluation. Imaging myocardial necrosis is marginal in conformation of majority of acute myocardial infarctions. It is used to assess area at risk after thrombolytic therapy for evolving myocardial infarction using dual-isotope techniques (perfusion agent with infarct-avid tracer in dual isotope technique). Antimyosin antibodies are useful also for confirmation of subacute or remote infarction, myocarditis or rejection after cardiac transplantation. Metabolic and receptor imaging are promising in evaluation of cardiomyopathies and myocardial viability not only on positron emission tomography but also on available imaging systems. In conclusion, new techniques and new radiopharmaceuticals for cardiovascular imaging allow more accurate answers to clinical problems. As the possibilities for research and clinical PET are limited, further transfer of PET-results to convenient imaging modalities is promising. (author)

  20. Hybrid imaging: Instrumentation and Data Processing

    Science.gov (United States)

    Cal-Gonzalez, Jacobo; Rausch, Ivo; Shiyam Sundar, Lalith K.; Lassen, Martin L.; Muzik, Otto; Moser, Ewald; Papp, Laszlo; Beyer, Thomas

    2018-05-01

    State-of-the-art patient management frequently requires the use of non-invasive imaging methods to assess the anatomy, function or molecular-biological conditions of patients or study subjects. Such imaging methods can be singular, providing either anatomical or molecular information, or they can be combined, thus, providing "anato-metabolic" information. Hybrid imaging denotes image acquisitions on systems that physically combine complementary imaging modalities for an improved diagnostic accuracy and confidence as well as for increased patient comfort. The physical combination of formerly independent imaging modalities was driven by leading innovators in the field of clinical research and benefited from technological advances that permitted the operation of PET and MR in close physical proximity, for example. This review covers milestones of the development of various hybrid imaging systems for use in clinical practice and small-animal research. Special attention is given to technological advances that helped the adoption of hybrid imaging, as well as to introducing methodological concepts that benefit from the availability of complementary anatomical and biological information, such as new types of image reconstruction and data correction schemes. The ultimate goal of hybrid imaging is to provide useful, complementary and quantitative information during patient work-up. Hybrid imaging also opens the door to multi-parametric assessment of diseases, which will help us better understand the causes of various diseases that currently contribute to a large fraction of healthcare costs.

  1. Hybrid Imaging: Instrumentation and Data Processing

    Directory of Open Access Journals (Sweden)

    Jacobo Cal-Gonzalez

    2018-05-01

    Full Text Available State-of-the-art patient management frequently requires the use of non-invasive imaging methods to assess the anatomy, function or molecular-biological conditions of patients or study subjects. Such imaging methods can be singular, providing either anatomical or molecular information, or they can be combined, thus, providing “anato-metabolic” information. Hybrid imaging denotes image acquisitions on systems that physically combine complementary imaging modalities for an improved diagnostic accuracy and confidence as well as for increased patient comfort. The physical combination of formerly independent imaging modalities was driven by leading innovators in the field of clinical research and benefited from technological advances that permitted the operation of PET and MR in close physical proximity, for example. This review covers milestones of the development of various hybrid imaging systems for use in clinical practice and small-animal research. Special attention is given to technological advances that helped the adoption of hybrid imaging, as well as to introducing methodological concepts that benefit from the availability of complementary anatomical and biological information, such as new types of image reconstruction and data correction schemes. The ultimate goal of hybrid imaging is to provide useful, complementary and quantitative information during patient work-up. Hybrid imaging also opens the door to multi-parametric assessment of diseases, which will help us better understand the causes of various diseases that currently contribute to a large fraction of healthcare costs.

  2. State of the art of teledermatopathology.

    Science.gov (United States)

    Massone, Cesare; Brunasso, Alexandra M G; Campbell, Terri M; Soyer, H Peter

    2008-10-01

    Teledermatopathology may involve real-time transmission of images from distant locations to consulting pathologists by the remote manipulation of a robotic microscope. Alternatively, the static store-and-forward option involves the single-file transmission of subjectively preselected and captured areas of microscopic images by a referring physician. The recent introduction of virtual slide systems (VSS) involves the digitization of whole slides at high resolution thus enabling the user to view any part of the specimen at any magnification. Such technology has surmounted previous restrictions caused by the size of preselected areas and specimen sampling for telepathology. In terms of client access, these VSS may be stored on a virtual slide server, made available on the Web for remote consultation by pathologists via an integrated virtual slide client network. Despite store-and-forward teledermatopathology being the most frequently used and less expensive approach to teledermatopathology, VSS represents the future in this discipline. The recent pilot studies suggest that the use of remote expert consultants in diagnostic dermatopathology can be integrated into daily routine, teleconsultation, and teleteaching. The new technology enables rapid and reproducible diagnoses, but despite its usability, VSS is not completely feasible for teledermatopathology of inflammatory skin diseases as the performance seems to be influenced by the availability of complete clinical data. Improvements in the diagnostic facility will no doubt follow from further development of the VSS, the slide processor, and of course training in the use of virtual microscope. Undoubtedly, as technology becomes even more sophisticated in the future, VSS will overcome the present drawbacks and find its place in all facets of teledermatopathology.

  3. Guide to state-of-the-art electron devices

    CERN Document Server

    2013-01-01

    Concise, high quality and comparative overview of state-of-the-art electron device development, manufacturing technologies and applications Guide to State-of-the-Art Electron Devices marks the 60th anniversary of the IEEE Electron Devices Committee and the 35th anniversary of the IEEE Electron Devices Society, as such it defines the state-of-the-art of electron devices, as well as future directions across the entire field. Spans full range of electron device types such as photovoltaic devices, semiconductor manufacturing and VLSI technology and circuits, covered by IEEE Electron and Devices Society Contributed by internationally respected members of the electron devices community A timely desk reference with fully-integrated colour and a unique lay-out with sidebars to highlight the key terms Discusses the historical developments and speculates on future trends to give a more rounded picture of the topics covered A valuable resource R&D managers; engineers in the semiconductor industry; applied scientists...

  4. State of the art undersøgelse

    DEFF Research Database (Denmark)

    Nielsen, Nils

    1998-01-01

    Dette skrift omhandler nogle af de erfaringer der til dato er opnået i forbindelse med standby projektets udførelse. Hovedtemaet er en “State of the art undersøgelse” der omhandler standby-spændingsforsyninger, samt komponenter der kan anvendes til konstruktion af dem......Dette skrift omhandler nogle af de erfaringer der til dato er opnået i forbindelse med standby projektets udførelse. Hovedtemaet er en “State of the art undersøgelse” der omhandler standby-spændingsforsyninger, samt komponenter der kan anvendes til konstruktion af dem...

  5. PARA'04, State-of-the-art in scientific computing

    DEFF Research Database (Denmark)

    Madsen, Kaj; Wasniewski, Jerzy

    This meeting in the series, the PARA'04 Workshop with the title ``State of the Art in Scientific Computing'', was held in Lyngby, Denmark, June 20-23, 2004. The PARA'04 Workshop was organized by Jack Dongarra from the University of Tennessee and Oak Ridge National Laboratory, and Kaj Madsen and J...

  6. The job demands-resources model : state of the art

    NARCIS (Netherlands)

    Bakker, A.B.; Demerouti, E.

    2007-01-01

    Purpose - The purpose of this paper is to give a state-of-the art overview of the Job Demands-Resources (JD-R) model Design/methodology/approach - The strengths and weaknesses of the demand-control model and the effort-reward imbalance model regarding their predictive value for employee well being

  7. State of the art: alumina ceramics for energy applications

    International Nuclear Information System (INIS)

    Hauth, W.E.; Stoddard, S.D.

    1978-01-01

    Prominent ceramic raw materials and products manufacturers were surveyed to determine the state of the art for alumina ceramic fabrication. This survey emphasized current capabilities and limitations for fabrication of large, high-density, high-purity, complex shapes. Some directions are suggested for future needs and development

  8. Augmented Reality and Mobile Learning: The State of the Art

    Science.gov (United States)

    FitzGerald, Elizabeth; Ferguson, Rebecca; Adams, Anne; Gaved, Mark; Mor, Yishay; Thomas, Rhodri

    2013-01-01

    In this paper, the authors examine the state of the art in augmented reality (AR) for mobile learning. Previous work in the field of mobile learning has included AR as a component of a wider toolkit but little has been done to discuss the phenomenon in detail or to examine in a balanced fashion its potential for learning, identifying both positive…

  9. Text Generation: The State of the Art and the Literature.

    Science.gov (United States)

    Mann, William C.; And Others

    This report comprises two documents which describe the state of the art of computer generation of natural language text. Both were prepared by a panel of individuals who are active in research on text generation. The first document assesses the techniques now available for use in systems design, covering all of the technical methods by which…

  10. Flexible AC transmission systems: the state of the art

    Energy Technology Data Exchange (ETDEWEB)

    Edris, Abdel-Aty [Electric Power Research Inst., Palo Alto, CA (United States). Electric Systems Division

    1994-12-31

    Flexible AC transmission systems (FACTS) is a concept promoting the use of power electronic controllers to enhance the controllability and usable capacity of AC transmission. This paper presents the state of the art of FACTS and the status of the current projects for the application of the FACTS controllers in transmission systems. (author) 8 refs., 8 figs.

  11. Sensors and Technologies in Spain: State-of-the-Art

    Directory of Open Access Journals (Sweden)

    Gonzalo Pajares

    2014-08-01

    Full Text Available The aim of this special issue was to provide a comprehensive view on the state-of-the-art sensor technology in Spain. Different problems cause the appearance and development of new sensor technologies and vice versa, the emergence of new sensors facilitates the solution of existing real problems. [...

  12. Three State-of-the-Art Methods for Condition Monitoring

    NARCIS (Netherlands)

    Grimmelius, H.T.; Meiler, P.P.; Maas, H.L.M.M.; Bonnier, B.; Grevink, J.S.; Kuilenburg, R.F. van

    1999-01-01

    This paper describes and compares three different state-of-the-art condition monitoring techniques: first principles, feature extraction, and neural networks. The focus of the paper is on the application of the techniques, not on the underlying theory. Each technique is described briefly and is

  13. The state-of-the-art of HSR in Europe.

    NARCIS (Netherlands)

    Hansen, J.

    2009-01-01

    In this section of the workshop we present an overview based on mapping the current state-of-the-art concerning various fields of health services research, addressing the different levels of analysis in HSR. (1) HSR at the level of health care systems, being national or sometimes regional entities,

  14. Paediatric thoracoscopy: State of the art | Van Niekerk | South ...

    African Journals Online (AJOL)

    Many advanced procedures, including lobectomy, repair of tracheo-oesophageal fistula, excision of mediastinal tumours and diaphragmatic hernia repairs, are being done routinely in paediatric surgery centres around the world. This article reviews the state of the art of thoracoscopic surgery in children. The author selected ...

  15. State of the art report on design for X

    DEFF Research Database (Denmark)

    Papanikolaou, Apostolos; Andersen, Poul; Kristensen, Hans Otto Holmegaard

    2009-01-01

    The present State of the Art report aims at defining and reviewing the curent state of the ship design process in the frame of a holistic approach, accounting for various objectives and constraints. The report addresses mainly the design of transportation carriers, though some covered aspects...

  16. State-of-the-art of home networking

    NARCIS (Netherlands)

    Koonen, A.M.J.; Popov, M.

    2012-01-01

    To introduce the Symposium on "Indoor Optical Networks: a Promising Way to a Converged Service Delivery", this presentation will give a brief overview of state-of-the-art home networking architectures, technologies and applications covering both technical and techno-economic aspects.

  17. State-of-the-Art in Open Courseware Initiatives Worldwide

    Science.gov (United States)

    Vladoiu, Monica

    2011-01-01

    We survey here the state-of-the-art in open courseware initiatives worldwide. First, the MIT OpenCourseWare project is overviewed, as it has been the real starting point of the OCW movement. Usually, open courseware refers to a free and open digital publication of high quality university level educational materials that are organized as courses,…

  18. The state of the art in static and dynamic games

    NARCIS (Netherlands)

    De Giovanni, P.

    2009-01-01

    Purpose - The purpose of this paper is to investigate the state of the art in static and dynamic games (or inter-firm relationships). This research area has changed significantly over the last 25 years through the development of phenomena such as the supply chain and the progressive overcoming of

  19. State of the art Advanced Driver Assistance Systems (ADAS).

    NARCIS (Netherlands)

    OEI, H.-L.

    2017-01-01

    An overview of state-of-the-art ADA Advanced Driver Assistance systems is given. First a main structuring system for the ADA systems is presented, needed for purposes of relevancy, and consistency : the three phases in the accident process, i.e. pre-crash, crash and post-crash; the driving task at

  20. New simulators from old - achieving state-of-the-art simulation without state-of-the-art costs

    International Nuclear Information System (INIS)

    Heilmeier, H.J.; Rosser, R.M.; Fyffe, K.L.; Gaerttner, G.F.; Chulick, E.T.

    1990-01-01

    Achieving a state-of-the-art simulator for operator training requires neither the expensive remodeling of old simulators nor the acquisition of very expensive new machines. In this paper the authors present two distinct cases where older training simulators have been upgraded to meet training requirements with a minimum of inexpensive hardware additions, including plug-in/-out panels, and software changes

  1. State-of-the-art in Heterogeneous Computing

    Directory of Open Access Journals (Sweden)

    Andre R. Brodtkorb

    2010-01-01

    Full Text Available Node level heterogeneous architectures have become attractive during the last decade for several reasons: compared to traditional symmetric CPUs, they offer high peak performance and are energy and/or cost efficient. With the increase of fine-grained parallelism in high-performance computing, as well as the introduction of parallelism in workstations, there is an acute need for a good overview and understanding of these architectures. We give an overview of the state-of-the-art in heterogeneous computing, focusing on three commonly found architectures: the Cell Broadband Engine Architecture, graphics processing units (GPUs, and field programmable gate arrays (FPGAs. We present a review of hardware, available software tools, and an overview of state-of-the-art techniques and algorithms. Furthermore, we present a qualitative and quantitative comparison of the architectures, and give our view on the future of heterogeneous computing.

  2. Modelling and simulation SSM: latest state of the art technology

    CSIR Research Space (South Africa)

    Jahajeeah, N

    2005-10-01

    Full Text Available as one phase ? One Phase model ?Wider volume solid fraction 0 – 1 ? Implementation in Power Law Cut-Off Model (PLCO) of Procast Supporting the Manufacturing and Materials Industry in its quest for global competitiveness Assumptions of the PLCO Model... and Materials Industry in its quest for global competitiveness Modelling and Simulation SSM Latest state of the art technology N Jahajeeah Supporting the Manufacturing and Materials Industry in its quest for global competitiveness BEHAVIOUR OF THIXOTROPIC...

  3. Electron beam melting state-of-the-art 1984

    International Nuclear Information System (INIS)

    Bakish, R.

    1984-01-01

    In 1984 electron beam melting and refining appear poised for an important new growth phase. The driving force for this phase is improved production economics made possible by technological advances. There is also a new and exciting growth application for electron beam melting: its use for surface properties beneficiation. This article is based in part on the content of the Conference on Electron Beam Melting and Refining, The State-of-the-Art 1983, held in November 1983 in Reno, Nevada

  4. Leadership and Fairness: The state of the art.

    OpenAIRE

    van Knippenberg, D.; de Cremer, D.; van Knippenberg, B.M.

    2007-01-01

    textabstractResearch in leadership effectiveness has paid less to the role of leader fairness than probably it should have. More recently, this has started to change. To capture this development, we review the empirical literature in leadership and fairness to define the field of leadership and fairness, to assess the state of the art, and to identify a research agenda for future efforts in the field. The review shows that leader distributive, procedural, and especially interactional fairness...

  5. Exchange rate predictability and state-of-the-art models

    OpenAIRE

    Yeșin, Pınar

    2016-01-01

    This paper empirically evaluates the predictive performance of the International Monetary Fund's (IMF) exchange rate assessments with respect to future exchange rate movements. The assessments of real trade-weighted exchange rates were conducted from 2006 to 2011, and were based on three state-of-the-art exchange rate models with a medium-term focus which were developed by the IMF. The empirical analysis using 26 advanced and emerging market economy currencies reveals that the "diagnosis" of ...

  6. State of the art survey of network operating systems development

    Science.gov (United States)

    1985-01-01

    The results of the State-of-the-Art Survey of Network Operating Systems (NOS) performed for Goddard Space Flight Center are presented. NOS functional characteristics are presented in terms of user communication data migration, job migration, network control, and common functional categories. Products (current or future) as well as research and prototyping efforts are summarized. The NOS products which are revelant to the space station and its activities are evaluated.

  7. Ascertaining the international state of the art of PSA methodology

    International Nuclear Information System (INIS)

    Linden, J. von

    1998-01-01

    Plant-specific PSAs, to be performed within the framework of the Periodic Safety Review of German Nuclear Power Plants require further development of the methodology. For that purpose foreign PSA-guidelines and PSA-reviewes as well as relevant literature are examined and appropriate insights are adopted within task A.2 of project SR 2096. The main goal of these activities is to achieve a comparison of the state of the art of PSA-methodologies applied abroad and in Germany. The German state of the art refers to the extent as is documented in the German PSA Guide (Leitfaden Probabilistische Sicherheitsanalyse /PSUe97/) which has to be used for the Periodic Safety Review of German Nuclear Power Plants. The structure for the evaluation is based on the working steps of a PSA. In total, according to the objectives of the Periodic Safety Review the German approach for plant-specific PSAs based on the German PSA Guide is conform to the state of the art abroad. Identified deviations in some details are evaluated reflecting the view of GRS. Particular aspects resulting from the evaluation should be considered for further development of the German PSA Guide. (orig.) [de

  8. State-of-the-Art Methods for Brain Tissue Segmentation: A Review.

    Science.gov (United States)

    Dora, Lingraj; Agrawal, Sanjay; Panda, Rutuparna; Abraham, Ajith

    2017-01-01

    Brain tissue segmentation is one of the most sought after research areas in medical image processing. It provides detailed quantitative brain analysis for accurate disease diagnosis, detection, and classification of abnormalities. It plays an essential role in discriminating healthy tissues from lesion tissues. Therefore, accurate disease diagnosis and treatment planning depend merely on the performance of the segmentation method used. In this review, we have studied the recent advances in brain tissue segmentation methods and their state-of-the-art in neuroscience research. The review also highlights the major challenges faced during tissue segmentation of the brain. An effective comparison is made among state-of-the-art brain tissue segmentation methods. Moreover, a study of some of the validation measures to evaluate different segmentation methods is also discussed. The brain tissue segmentation, content in terms of methodologies, and experiments presented in this review are encouraging enough to attract researchers working in this field.

  9. Vertebroplasty - state of the art; Vertebroplastie - ''state of the art''

    Energy Technology Data Exchange (ETDEWEB)

    Wilhelm, K. [Akademisches Lehrkrankenhaus der Rheinischen Friedrich-Wilhelms-Universitaet Bonn, Radiologie und Nuklearmedizin, Johanniter-Krankenhaus - Johanniter GmbH, Bonn (Germany)

    2015-10-15

    Percutaneous vertebroplasty (PVP) using PMMA (polymethyl methacrylate) was first described in 1987 by Gallibert and Deramond for the treatment of vertebral body instability in patients with aggressive forms of vertebral hemangioma. Other types of painful osteolytic bone lesions, such as osteoporotic vertebral fractures and vertebral metastasis are in the meantime more commonly treated using this method. Within the last few years, this technique has become widely accepted and it is proposed for osteolytic bone lesions in areas that are more difficult to approach surgically, e.g., the pelvis and sacrum. Rapid pain relief and resulting stability have conferred an important role upon osteoplasty especially in palliative tumor-treatment for patients with shortened expected life spans. In addition, combined treatment of painful osteolytic metastases with image-guided thermoablation and percutaneous cement injection has been shown to be a safe palliative modality in the therapy of nonresectable tumors. (orig.) [German] Die Vertebroplastie ist ein minimal-invasives Verfahren, bei dem unter Durchleuchtung oder im CT Knochenzement mithilfe einer Hohlnadel in einen schmerzhaften Wirbelkoerper eingebracht wird. Die Technik wurde initial zur Behandlung aggressiver Wirbelkoerperhaemangiome beschrieben. Inzwischen stellen andere schmerzhafte Wirbelkoerperprozesse, vornehmlich osteolytische Metastasen sowie osteoporotische Wirbelkoerperfrakturen die haeufigsten Indikationen zur Durchfuehrung einer Vertebroplastie dar. Methode und Technik der Zementapplikation werden zwischenzeitlich erfolgreich auch bei ausserhalb der Wirbelsaeule bestehenden gutartigen Pathologien, z. B. bei Ermuedungsfrakturen des Os sacrum in Form der Sakroplastie sowie insbesondere schmerzhaften, metastatisch-osteolytischen Befunden als palliative Therapiemassnahme (Osteoplastie) eingesetzt. Im Rahmen palliativer Therapiekonzepte wird die Vertebroplastie in der Radiologie zunehmend in Kombination mit

  10. State-of-the-art Versus Time-triggered Object Tracking in Advanced Driver Assistance Systems

    Directory of Open Access Journals (Sweden)

    Moritz Koplin

    2013-04-01

    Full Text Available Most state-of-the-art driver assistance systems cannot guarantee that real-time images of object states are updated within a given time interval, because the object state observations are typically sampled by uncontrolled sensors and transmitted via an indeterministic bus system such as CAN. To overcome this shortcoming, a paradigm shift toward time-triggered advanced driver assistance systems based on a deterministic bus system, such as FlexRay, is under discussion. In order to prove the feasibility of this paradigm shift, this paper develops different models of a state-of-the-art and a time-triggered advanced driver assistance system based on multi-sensor object tracking and compares them with regard to their mean performance. The results show that while the state-of-the-art model is advantageous in scenarios with low process noise, it is outmatched by the time-triggered model in the case of high process noise, i.e., in complex situations with high dynamic.

  11. Geothermal well log interpretation state of the art. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Sanyal, S.K.; Wells, L.E.; Bickham, R.E.

    1980-01-01

    An in-depth study of the state of the art in Geothermal Well Log Interpretation has been made encompassing case histories, technical papers, computerized literature searches, and actual processing of geothermal wells from New Mexico, Idaho, and California. A classification scheme of geothermal reservoir types was defined which distinguishes fluid phase and temperature, lithology, geologic province, pore geometry, salinity, and fluid chemistry. Major deficiencies of Geothermal Well Log Interpretation are defined and discussed with recommendations of possible solutions or research for solutions. The Geothermal Well Log Interpretation study and report has concentrated primarily on Western US reservoirs. Geopressured geothermal reservoirs are not considered.

  12. The state of the art in intrusion prevention and detection

    CERN Document Server

    Pathan, Al-Sakib Khan

    2013-01-01

    The State of the Art in Intrusion Prevention and Detection analyzes the latest trends and issues surrounding intrusion detection systems in computer networks, especially in communications networks. Its broad scope of coverage includes wired, wireless, and mobile networks; next-generation converged networks; and intrusion in social networks.Presenting cutting-edge research, the book presents novel schemes for intrusion detection and prevention. It discusses tracing back mobile attackers, secure routing with intrusion prevention, anomaly detection, and AI-based techniques. It also includes infor

  13. State of the art: two-phase flow calibration techniques

    International Nuclear Information System (INIS)

    Stanley, M.L.

    1977-01-01

    The nuclear community faces a particularly difficult problem relating to the calibration of instrumentation in a two-phase flow steam/water environment. The rationale of the approach to water reactor safety questions in the United States demands that accurate measurements of mass flows in a decompressing two-phase flow be made. An accurate measurement dictates an accurate calibration. This paper addresses three questions relating to the state of the art in two-phase calibration: (1) What do we mean by calibration. (2) What is done now. (3) What should be done

  14. Leadless Pacemakers: State of the Art and Future Perspectives.

    Science.gov (United States)

    Della Rocca, Domenico G; Gianni, Carola; Di Biase, Luigi; Natale, Andrea; Al-Ahmad, Amin

    2018-03-01

    Leadless pacemaker therapy is a new technology that aims at avoiding lead- and pocket-related complications of conventional transvenous and epicardial pacing. To date, 2 self-contained leadless pacemakers for right ventricular pacing have been clinically available: the Nanostim Leadless Pacemaker System and the Micra Transcatheter Pacing System. Additionally, a new multicomponent leadless pacemaker for endocardial left ventricular pacing has been proposed as an alternative choice for cardiac resynchronization therapy. In this review, we describe the state of the art of leadless pacing and compare the currently available devices with traditional transvenous leadless pacemakers. Copyright © 2017 Elsevier Inc. All rights reserved.

  15. Bidirectional Texture Function Modeling: State of the Art Survey

    Czech Academy of Sciences Publication Activity Database

    Filip, Jiří; Haindl, Michal

    2009-01-01

    Roč. 31, č. 11 (2009), s. 1921-1940 ISSN 0162-8828 R&D Projects: GA MŠk 1M0572; GA ČR GA102/08/0593; GA AV ČR 1ET400750407 Grant - others:EC Marie Curie(BE) 41358; GA MŠk(CZ) 2C06019 Institutional research plan: CEZ:AV0Z10750506 Keywords : BTF * surface texture * 3D texture Subject RIV: BD - Theory of Information Impact factor: 4.378, year: 2009 http://library.utia.cas.cz/separaty/2009/RO/filip-bidirectional texture function modeling state of the art survey.pdf

  16. Nuclear power plant decommissioning: state-of-the-art review

    International Nuclear Information System (INIS)

    Williams, D.H.

    1984-01-01

    A brief orientation to the state-of-the-art of nuclear power plant decommissioning discusses the related areas of experience, tools and techniques, and planning. There have been 68 nuclear reactor decommissionings to date, including 9 power plants, some of which were mothballed. The picture suggests that the term art may be misapplied since decommissioning is now more of a mature commercial industrial than a research and development endeavor. It also suggests that the nuclear industry has shown foresight by preparing for it before a crisis situation developed. Some of this has already influenced operators of coal power plants, especially where hazardous materials may be involved. 33 references, 1 table

  17. State-of-the-art report on radioactive waste disposal

    International Nuclear Information System (INIS)

    Larsson, A.

    1989-01-01

    In view of the considerable work required to develop repositories for radioactive waste, an extensive international co-operation has evolved within the area. The work has also engaged the IAEA to a great extent. The Agency has published a number of reports, covering different aspects of waste disposal. Following a recommendation by its Technical Review Committee on Underground Disposal (TRCUD) the Agency will publish a ''state-of-the-art'' report on radioactive waste disposal. The report is still in the preparation stage. In this article the principal subjects of the future report are discussed

  18. State of the art of UO2 fuel fabrication processes

    International Nuclear Information System (INIS)

    Henke, M.; Klemm, U.

    1980-01-01

    Starting from the need of UO 2 for thermal power reactors in the period from 1980 to 1990 and the role of UF 6 conversion into UO 2 within the fuel cycle, the state-of-the-art of the three established industrial processes - ADU process, AUC process, IDR process - is assessed. The number of process stages and requirements on process management are discussed. In particular, the properties of the fabricated UO 2 powders, their influence on the following pellet production and on operational behaviour of the fuel elements under reactor conditions are described. Hence, an evaluation of the three essential conversion processes is derived. (author)

  19. Blade root design a state of the art survey

    Energy Technology Data Exchange (ETDEWEB)

    Sandberg, O

    1988-06-01

    This report was conceived in the wake of recent blade root failures in several horizontal axis turbines. Ten blade root designs are presented. They are considered to represent the state of the art. The information was obtained partly from literature partly from a few important projects with little or no documentation. Suggestions are made how to proceed in the development of the bonded bolt type of root retention. Presently the conclusion is that this type of arrangement seems the most promising. Developments in this field should be closely monitored, however. For this type of very high cycle fatigue designs there is a need for two redundant design principles. (author).

  20. Supplier selection problem: A state-of-the-art review

    Directory of Open Access Journals (Sweden)

    Nilesh R. Ware

    2012-08-01

    Full Text Available In the global competitiveness and growing market environment, “Actual competition is not between firms against firm, than supplier against supplier”. Globally in the fastest market development world gets closer and closer. Consumers prefer fast delivery, economical product, excellent service and high quality product with desired service level. For successful management of this supply chain, supplier considered as the base source for all processes. Therefore, an efficient supplier selection and evaluation process needs to be incorporate. The main purpose of this paper is to provide an extensive state-of-the-art literature review and critique of the studies related to various aspects of supplier selection problem over the past two decades. Research papers appearing in the reputed and leading international journals from 1991 to 2011 are gathered and analyzed. Primary focus is given on more than 200 published and unpublished works. It has been referred extensively to carry out state-of-the-art review for supplier selection problem. Finally, paper provides future perspective based on current research trends available in the published literature.

  1. State-of-the-art MRI techniques in neuroradiology: principles, pitfalls, and clinical applications

    Energy Technology Data Exchange (ETDEWEB)

    Viallon, Magalie [Universite de Lyon, CREATIS, UMR CNRS 5220 - INSERM U1044, INSA de Lyon, Lyon (France); Universite de Lyon-Saint-Etienne, Department of Radiology, Centre Hospitalier Universitaire de Saint-Etienne, Saint Etienne (France); Cuvinciuc, Victor; Barnaure-Nachbar, Isabelle; Lovblad, Karl-Olof; Haller, Sven [University Hospital of Geneva, Department of Neuroradiology, Geneva (Switzerland); Delattre, Benedicte; Toso-Patel, Seema; Becker, Minerva [University Hospital of Geneva, Department of Radiology, Geneva (Switzerland); Merlini, Laura [University Hospital of Geneva, Department of Pediatric Radiology, Geneva (Switzerland)

    2015-05-01

    This article reviews the most relevant state-of-the-art magnetic resonance (MR) techniques, which are clinically available to investigate brain diseases. MR acquisition techniques addressed include notably diffusion imaging (diffusion-weighted imaging (DWI), diffusion tensor imaging (DTI), and diffusion kurtosis imaging (DKI)) as well as perfusion imaging (dynamic susceptibility contrast (DSC), arterial spin labeling (ASL), and dynamic contrast enhanced (DCE)). The underlying models used to process these images are described, as well as the theoretic underpinnings of quantitative diffusion and perfusion MR imaging-based methods. The technical requirements and how they may help to understand, classify, or follow-up neurological pathologies are briefly summarized. Techniques, principles, advantages but also intrinsic limitations, typical artifacts, and alternative solutions developed to overcome them are discussed. In this article, we also review routinely available three-dimensional (3D) techniques in neuro MRI, including state-of-the-art and emerging angiography sequences, and briefly introduce more recently proposed 3D quantitative neuro-anatomy sequences, and new technology, such as multi-slice and multi-transmit imaging. (orig.)

  2. State-of-the-art MRI techniques in neuroradiology: principles, pitfalls, and clinical applications

    International Nuclear Information System (INIS)

    Viallon, Magalie; Cuvinciuc, Victor; Barnaure-Nachbar, Isabelle; Lovblad, Karl-Olof; Haller, Sven; Delattre, Benedicte; Toso-Patel, Seema; Becker, Minerva; Merlini, Laura

    2015-01-01

    This article reviews the most relevant state-of-the-art magnetic resonance (MR) techniques, which are clinically available to investigate brain diseases. MR acquisition techniques addressed include notably diffusion imaging (diffusion-weighted imaging (DWI), diffusion tensor imaging (DTI), and diffusion kurtosis imaging (DKI)) as well as perfusion imaging (dynamic susceptibility contrast (DSC), arterial spin labeling (ASL), and dynamic contrast enhanced (DCE)). The underlying models used to process these images are described, as well as the theoretic underpinnings of quantitative diffusion and perfusion MR imaging-based methods. The technical requirements and how they may help to understand, classify, or follow-up neurological pathologies are briefly summarized. Techniques, principles, advantages but also intrinsic limitations, typical artifacts, and alternative solutions developed to overcome them are discussed. In this article, we also review routinely available three-dimensional (3D) techniques in neuro MRI, including state-of-the-art and emerging angiography sequences, and briefly introduce more recently proposed 3D quantitative neuro-anatomy sequences, and new technology, such as multi-slice and multi-transmit imaging. (orig.)

  3. MRI sequences in head and neck radiology. State of the art

    Energy Technology Data Exchange (ETDEWEB)

    Widmann, Gerlig; Henninger, Benjamin; Kremser, Christian; Jaschke, Werner [Medical Univ. of Innsbruck (Austria). Dept. of Radiology

    2017-05-15

    Magnetic resonance imaging (MRI) has become an essential imaging modality for the evaluation of head and neck pathologies. However, the diagnostic power of MRI is strongly related to the appropriate selection and interpretation of imaging protocols and sequences. The aim of this article is to review state-of-the-art sequences for the clinical routine in head and neck MRI and to describe the evidence for which medical question these sequences and techniques are useful. Literature review of state-of-the-art sequences in head and neck MRI. Basic sequences (T1w, T2w, T1wC+) and fat suppression techniques (TIRM/STIR, Dixon, Spectral Fat sat) are important tools in the diagnostic workup of inflammation, congenital lesions and tumors including staging. Additional sequences (SSFP (CISS, FIESTA), SPACE, VISTA, 3D-FLAIR) are used for pathologies of the cranial nerves, labyrinth and evaluation of endolymphatic hydrops in Meniere's disease. Vessel and perfusion sequences (3D-TOF, TWIST/TRICKS angiography, DCE) are used in vascular contact syndromes, vascular malformations and analysis of microvascular parameters of tissue perfusion. Diffusion-weighted imaging (EPI-DWI, non-EPI-DWI, RESOLVE) is helpful in cholesteatoma imaging, estimation of malignancy, and evaluation of treatment response and posttreatment recurrence in head and neck cancer. Understanding of MRI sequences and close collaboration with referring physicians improves the diagnostic confidence of MRI in the daily routine and drives further research in this fascinating image modality.

  4. MRI sequences in head and neck radiology. State of the art

    International Nuclear Information System (INIS)

    Widmann, Gerlig; Henninger, Benjamin; Kremser, Christian; Jaschke, Werner

    2017-01-01

    Magnetic resonance imaging (MRI) has become an essential imaging modality for the evaluation of head and neck pathologies. However, the diagnostic power of MRI is strongly related to the appropriate selection and interpretation of imaging protocols and sequences. The aim of this article is to review state-of-the-art sequences for the clinical routine in head and neck MRI and to describe the evidence for which medical question these sequences and techniques are useful. Literature review of state-of-the-art sequences in head and neck MRI. Basic sequences (T1w, T2w, T1wC+) and fat suppression techniques (TIRM/STIR, Dixon, Spectral Fat sat) are important tools in the diagnostic workup of inflammation, congenital lesions and tumors including staging. Additional sequences (SSFP (CISS, FIESTA), SPACE, VISTA, 3D-FLAIR) are used for pathologies of the cranial nerves, labyrinth and evaluation of endolymphatic hydrops in Meniere's disease. Vessel and perfusion sequences (3D-TOF, TWIST/TRICKS angiography, DCE) are used in vascular contact syndromes, vascular malformations and analysis of microvascular parameters of tissue perfusion. Diffusion-weighted imaging (EPI-DWI, non-EPI-DWI, RESOLVE) is helpful in cholesteatoma imaging, estimation of malignancy, and evaluation of treatment response and posttreatment recurrence in head and neck cancer. Understanding of MRI sequences and close collaboration with referring physicians improves the diagnostic confidence of MRI in the daily routine and drives further research in this fascinating image modality.

  5. One Step Closer to the Marketplace for State-of-the-Art Wind Turbine

    Science.gov (United States)

    Drivetrain | News | NREL One Step Closer to the Marketplace for State-of-the-Art Wind Turbine Drivetrain One Step Closer to the Marketplace for State-of-the-Art Wind Turbine Drivetrain April 1, 2016 modeling, and testing in state-of-the-art facilities designed to put the drivetrain through its paces

  6. Analysis of Respiratory Sounds: State of the Art

    Directory of Open Access Journals (Sweden)

    Sandra Reichert

    2008-01-01

    Full Text Available Objective This paper describes state of the art, scientific publications and ongoing research related to the methods of analysis of respiratory sounds. Methods and material Review of the current medical and technological literature using Pubmed and personal experience. Results The study includes a description of the various techniques that are being used to collect auscultation sounds, a physical description of known pathologic sounds for which automatic detection tools were developed. Modern tools are based on artificial intelligence and on technics such as artificial neural networks, fuzzy systems, and genetic algorithms… Conclusion The next step will consist in finding new markers so as to increase the efficiency of decision aid algorithms and tools.

  7. State of the art and prospects of nuclear power development

    International Nuclear Information System (INIS)

    Egorov, Yu.V.; Glushenkova, S.Z.

    1984-01-01

    State of the art and prospects of nuclear power development abroad except the COMECON countries and Yugoslavia, are considered. Both average electric power of power units and load factor (LF) are shown to increase. Data on both the total generating capacity and nuclear power generation in certain countries are given. The number of commissioned NPPs in the USA decreases but terms of their construction and licensing are reduced, program of fast breeder reactor construction is being realized, prohibition of nuclear fuel reprocessing in cancelled. France came to the second place in the world as regards the operating NPPs. The nuclear power generation in Japan makes up 13% of the total generating capacity in the country. The LF of the Japan NPPs with BWR and PWR in 1982 made up 70.7 and 69.8%, respectively. A higher reliability of NPPs, decrease in the time for periodical inspections and prolongation of the operating cycle have promoted an increase in the LF

  8. State of the art in perceptual design of hearing aids

    Science.gov (United States)

    Edwards, Brent W.; van Tasell, Dianne J.

    2002-05-01

    Hearing aid capabilities have increased dramatically over the past six years, in large part due to the development of small, low-power digital signal processing chips suitable for hearing aid applications. As hearing aid signal processing capabilities increase, there will be new opportunities to apply perceptually based knowledge to technological development. Most hearing loss compensation techniques in today's hearing aids are based on simple estimates of audibility and loudness. As our understanding of the psychoacoustical and physiological characteristics of sensorineural hearing loss improves, the result should be improved design of hearing aids and fitting methods. The state of the art in hearing aids will be reviewed, including form factors, user requirements, and technology that improves speech intelligibility, sound quality, and functionality. General areas of auditory perception that remain unaddressed by current hearing aid technology will be discussed.

  9. PRA: an evaluation of state-of-the-art

    International Nuclear Information System (INIS)

    Joksimovich, V.

    1985-01-01

    Some elements of the probabilistic risk assessment (PRA) methodology can be characterized as mature and are even ready for some kind of a standardization effort. Other elements are still, however, in a rapid state of evolution. Questions are continuously being asked regarding maturity of PRA techniques vis-a-vis a regulatory decision-making process. Establishing a framework for evaluating state-of-the-art in any technological field is a challenging task. An implementation of a selected framework to a satisfactory conclusion is a monumental task. Of course, these types of issues can be discussed meaningfully only if they are tied to a particular application. The author's participation in the NSF-sponsored risk assessment project is discussed in the paper. The evaluation employed here makes use of the following five evaluation criteria: logical soundness, completeness, accuracy, acceptability, and practicality

  10. [State of the art diagnostic criteria of severe periodontitis].

    Science.gov (United States)

    Ouyang, X Y

    2017-02-09

    Periodontitis could be categorized as mild, moderate, and severe according to the severity of the disease. This categorizing system could also be used together with other classification systems. The present article introduced the status about the case definition of severe periodontitis, including the standard of case definitions for surveillance of periodontitis reported by the Centers for Disease Control and Prevention (CDC) in partnership with the American Academy of Periodontology (AAP) and the consensus report on the definition of periodontitis case for use in risk factor research by Europe workshop. A consensus on the state of the art definition of severe periodontitis for use in clinical work was gained base on the expertise of Chinese Society of Periodontology, Chinese Association of Stomatology. The background of this consensus and the significance of the criteria for the case definition were discussed.

  11. The state-of-the-art port of entry workshop

    Energy Technology Data Exchange (ETDEWEB)

    Godfrey, B.

    1995-05-01

    The increased demand for freight movements through international ports of entry and the signing of the North American Free Trade Agreement (NAFTA) have increased freight traffic at border ports of entry. The State-of-the-Art Port of Entry Workshop initiated a dialogue among technologists and stakeholders to explore the potential uses of technology at border crossings and to set development priorities. International ports of entry are both information and labor intensive, and there are many promising technologies that could be used to provide timely information and optimize inspection resources. Participants universally held that integration of technologies and operations is critical to improving port services. A series of Next Steps was developed to address stakeholder issues and national priorities, such as the National Transportation Policy and National Drug Policy. This report documents the views of the various stakeholders and technologists present at the workshop and outlines future directions of study.

  12. State-of-the-art of biodegradable composite materials

    International Nuclear Information System (INIS)

    Baley, Ch.; Grohens, Y.; Pillin, I.

    2004-01-01

    Nowadays, the market demand for environment friendly materials is in strong growth. The biodegradable composites (biodegradable fibres and polymers) mainly extracted from renewable resources will be a major contributor to the production of new industrial high performance products partially solving the problem of waste management. At the end of the lifetime, a structural bio-composite could be be crushed and recycled through a controlled industrial composting process. This the state-of-the-art report focuses on the biopolymers the vegetable fibres properties, the mechanisms of biodegradation and the examples of biodegradable composites. Eco-design of new products requires these new materials for which a life cycle analysis is nevertheless necessary to validate their environmental benefits. (authors)

  13. State of the Art in Pediatric Lung Transplantation.

    Science.gov (United States)

    Lancaster, Timothy S; Eghtesady, Pirooz

    2018-04-24

    Pediatric lung transplantation is a highly specialized therapy for end stage pulmonary disease in children, performed in only a handful of transplant centers around the world. Advancement in the field has been made on many fronts in recent years, including in public policy and organ allocation strategies, donor selection and management, emerging technologies for donor lung rehabilitation and bridge-to-transplant support of listed candidates, and ongoing refinement of surgical techniques. Despite this progress, children continue to suffer discrepant waitlist mortality and longer waiting times than their adult counterparts, and face special challenges of donor availability and size matching. Here we review the current state of the art in pediatric lung transplantation, reviewing progress made to date and further opportunities to improve care for this unique group of patients. Copyright © 2018 Elsevier Inc. All rights reserved.

  14. State of the art in crystal oscillators - Present and future

    Science.gov (United States)

    Rosati, V. J.; Filler, R. L.; Schodowski, S. S.; Vig, J. R.

    It is pointed out that most military communication, navigation, surveillance and IFF systems which are currently under development require stable oscillators for frequency control and/or timing. Examples of such systems are the Single Channel Ground and Airborne Radio System (SINCGARS), MILSTAR, the Global Positioning System (GPS), the Combat Identification System (CIS), and several radar systems. In 1981, a survey and evaluation program was initiated with the aim to determine the state-of-the-art of both TCXOs (temperature compensated crystal oscillators) and OCXOs (oven controlled crystal oscillators). This program is continuing. The results obtained to date are considered because they can provide useful guidance to system users on the availability of stable oscillators.

  15. State of the art report on aging reliability analysis

    International Nuclear Information System (INIS)

    Choi, Sun Yeong; Yang, Joon Eon; Han, Sang Hoon; Ha, Jae Joo

    2002-03-01

    The goal of this report is to describe the state of the art on aging analysis methods to calculate the effects of component aging quantitatively. In this report, we described some aging analysis methods which calculate the increase of Core Damage Frequency (CDF) due to aging by including the influence of aging into PSA. We also described several research topics required for aging analysis for components of domestic NPPs. We have described a statistical model and reliability physics model which calculate the effect of aging quantitatively by using PSA method. It is expected that the practical use of the reliability-physics model will be increased though the process with the reliability-physics model is more complicated than statistical model

  16. Subliminal Priming—State of the Art and Future Perspectives

    Directory of Open Access Journals (Sweden)

    Mohamed Elgendi

    2018-05-01

    Full Text Available The influence of subliminal priming (behavior outside of awareness in humans is an interesting phenomenon and its understanding is crucial as it can impact behavior, choices, and actions. Given this, research about the impact of priming continues to be an area of investigative interest, and this paper provides a technical overview of research design strengths and issues in subliminal priming research. Efficient experiments and protocols, as well as associated electroencephalographic and eye movement data analyses, are discussed in detail. We highlight the strengths and weaknesses of different priming experiments that have measured affective (emotional and cognitive responses. Finally, very recent approaches and findings are described to summarize and emphasize state-of-the-art methods and potential future directions in research marketing and other commercial applications.

  17. State of the art metrics for aspect oriented programming

    Science.gov (United States)

    Ghareb, Mazen Ismaeel; Allen, Gary

    2018-04-01

    The quality evaluation of software, e.g., defect measurement, gains significance with higher use of software applications. Metric measurements are considered as the primary indicator of imperfection prediction and software maintenance in various empirical studies of software products. However, there is no agreement on which metrics are compelling quality indicators for novel development approaches such as Aspect Oriented Programming (AOP). AOP intends to enhance programming quality, by providing new and novel constructs for the development of systems, for example, point cuts, advice and inter-type relationships. Hence, it is not evident if quality pointers for AOP can be derived from direct expansions of traditional OO measurements. Then again, investigations of AOP do regularly depend on established coupling measurements. Notwithstanding the late reception of AOP in empirical studies, coupling measurements have been adopted as useful markers of flaw inclination in this context. In this paper we will investigate the state of the art metrics for measurement of Aspect Oriented systems development.

  18. Pattern Recognition and Natural Language Processing: State of the Art

    Directory of Open Access Journals (Sweden)

    Mirjana Kocaleva

    2016-05-01

    Full Text Available Development of information technologies is growing steadily. With the latest software technologies development and application of the methods of artificial intelligence and machine learning intelligence embededs in computers, the expectations are that in near future computers will be able to solve problems themselves like people do. Artificial intelligence emulates human behavior on computers. Rather than executing instructions one by one, as theyare programmed, machine learning employs prior experience/data that is used in the process of system’s training. In this state of the art paper, common methods in AI, such as machine learning, pattern recognition and the natural language processing (NLP are discussed. Also are given standard architecture of NLP processing system and the level thatisneeded for understanding NLP. Lastly the statistical NLP processing and multi-word expressions are described.

  19. Apoptosis imaging: current state of the art and future perspective

    International Nuclear Information System (INIS)

    Wang Feng; Wang Zizheng

    2007-01-01

    This review provides a critical and thorough overview of the radionpharmaceutical development and in vivo evaluation of all apoptosis-detecting radioligands that emerged so far, along with these possible applications in nuclear medicine. Radiolabelled annexin bears the promise of becoming a clinically applied radio-pharmaceutical with potential applications in cardiology and oncology. Visualization of cell death is important in pathologies such as myocardial infarction, atherosclerosis, and cancer. Furthermore, radiolabelled annexin may be developed as a tool for monitoring cell death-induceing or cell death-preventing therapies. Some future perspective are presented with the aim of promoting the development of potential new strategies in pursuit of the idealcell death-detecting radioligand. (authors)

  20. Transarterial embolization (TAE) as add-on to percutaneous radiofrequency ablation (RFA) for the treatment of renal tumors: Review of the literature, overview of state-of-the-art embolization materials and further perspective of advanced image-guided tumor ablation

    Energy Technology Data Exchange (ETDEWEB)

    Sommer, C.M., E-mail: christof.sommer@med.uni-heidelberg.de [Clinic for Diagnostic and Interventional Radiology, University Hospital Heidelberg, Heidelberg (Germany); Clinic for Diagnostic and Interventional Radiology, Klinikum Stuttgart, Katharinenhospital, Stuttgart (Germany); Pallwein-Prettner, L., E-mail: leo.pallwein-prettner@bhs.at [Department of Diagnostic and Interventional Radiology, Krankenhaus der Barmherzigen Schwestern Linz, Linz (Austria); Vollherbst, D.F., E-mail: dominik@vollherbst.de [Clinic for Radiology, Minimally-Invasive Therapies and Nuclear Medicine, SLK Kliniken Heilbronn GmbH, Heilbronn (Germany); Seidel, R., E-mail: roland.seidel@uks.eu [Clinic for Diagnostic and Interventional Radiology, Saarland University Medical Center, Homburg/Saar (Germany); Rieder, C., E-mail: christian.rieder@mevis.fraunhofer.de [Fraunhofer MEVIS, Institute for Medical Image Computing, Bremen (Germany); Radeleff, B.A., E-mail: boris.radeleff@med.uni-heidelberg.de [Clinic for Diagnostic and Interventional Radiology, University Hospital Heidelberg, Heidelberg (Germany); Kauczor, H.U., E-mail: hu.kauczor@med.uni-heidelberg.de [Clinic for Diagnostic and Interventional Radiology, University Hospital Heidelberg, Heidelberg (Germany); Wacker, F., E-mail: wacker.frank@mh-hannover.de [Department of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover (Germany); Richter, G.M., E-mail: g.richter@klinikum-stuttgart.de [Clinic for Diagnostic and Interventional Radiology, Klinikum Stuttgart, Katharinenhospital, Stuttgart (Germany); Bücker, A., E-mail: arno.buecker@uks.eu [Clinic for Diagnostic and Interventional Radiology, Saarland University Medical Center, Homburg/Saar (Germany); Rodt, T., E-mail: rodt.thomas@mh-hannover.de [Department of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover (Germany); and others

    2017-01-15

    Highlights: • TAE as add-on to percutaneous RFA is feasible, safe, and very effective. • State-of-the-art embolization materials include tightly-size-calibrated microspheres. • MWA, cryoablation and IRE are TA systems beyond RFA. • Visible beads rank among the most promising innovative embolization materials. • Software-based solutions will be increasingly important for treatment guidance. - Abstract: Percutaneous radiofrequency ablation (RFA) for the treatment of stage I renal cell carcinoma has recently gained significant attention as the now available long-term and controlled data demonstrate that RFA can result in disease-free and cancer-specific survival comparable with partial and/or radical nephrectomy. In the non-controlled single center trials, however, the rates of treatment failure vary. Operator experience and ablation technique may explain some of the different outcomes. In the controlled trials, a major limitation is the lack of adequate randomization. In case reports, original series and overview articles, transarterial embolization (TAE) before percutaneous RFA was promising to increase tumor control and to reduce complications. The purpose of this study was to systematically review the literature on TAE as add-on to percutaneous RFA for renal tumors. Specific data regarding technique, tumor and patient characteristics as well as technical, clinical and oncologic outcomes have been analyzed. Additionally, an overview of state-of-the-art embolization materials and the radiological perspective of advanced image-guided tumor ablation (TA) will be discussed. In conclusion, TAE as add-on to percutaneous RFA is feasible and very effective and safe for the treatment of T1a tumors in difficult locations and T1b tumors. Advanced radiological techniques and technologies such as microwave ablation, innovative embolization materials and software-based solutions are now available, or will be available in the near future, to reduce the limitations of

  1. Dose Reduction and Dose Management in Computed Tomography - State of the Art.

    Science.gov (United States)

    Zinsser, Dominik; Marcus, Roy; Othman, Ahmed E; Bamberg, Fabian; Nikolaou, Konstantin; Flohr, Thomas; Notohamiprodjo, Mike

    2018-03-13

     For years, the number of performed CT examinations has been rising. At the same time, computed tomography became more dose efficient. The aim of this article is to give an overview about the state of the art in dose reduction in CT and to highlight currently available tools in dose management.  By performing a literature research on Pubmed regarding dose reduction in CT, relevant articles were identified and analyzed.  Technical innovations with individual adaptation of tube current and voltage as well as iterative image reconstruction enable a considerable dose reduction with preserved image quality. At the same time, dedicated software tools are able to handle huge amounts of data and allow to optimize existing examination protocols.   · CT examinations are increasingly performed and contribute considerably to non-natural radiation exposure.. · A correct indication is crucial for each CT examination.. · The examination protocol has to be tailored to the medical question and patient.. · Multiple technical innovations enable considerable dose reduction with constant image quality.. · Dose management with dedicated software tools gains importance.. · Zinsser D, Marcus R, Othman AE et al. Dose reduction and dose management in computed tomography - State of the art. Fortschr Röntgenstr 2018; DOI: 10.1055/s-0044-101261. © Georg Thieme Verlag KG Stuttgart · New York.

  2. Cardiac hybrid imaging

    Energy Technology Data Exchange (ETDEWEB)

    Gaemperli, Oliver [University Hospital Zurich, Cardiac Imaging, Zurich (Switzerland); University Hospital Zurich, Nuclear Cardiology, Cardiovascular Center, Zurich (Switzerland); Kaufmann, Philipp A. [University Hospital Zurich, Cardiac Imaging, Zurich (Switzerland); Alkadhi, Hatem [University Hospital Zurich, Institute of Diagnostic and Interventional Radiology, Zurich (Switzerland)

    2014-05-15

    Hybrid cardiac single photon emission computed tomography (SPECT)/CT imaging allows combined assessment of anatomical and functional aspects of cardiac disease. In coronary artery disease (CAD), hybrid SPECT/CT imaging allows detection of coronary artery stenosis and myocardial perfusion abnormalities. The clinical value of hybrid imaging has been documented in several subsets of patients. In selected groups of patients, hybrid imaging improves the diagnostic accuracy to detect CAD compared to the single imaging techniques. Additionally, this approach facilitates functional interrogation of coronary stenoses and guidance with regard to revascularization procedures. Moreover, the anatomical information obtained from CT coronary angiography or coronary artery calcium scores (CACS) adds prognostic information over perfusion data from SPECT. The use of cardiac hybrid imaging has been favoured by the dissemination of dedicated hybrid systems and the release of dedicated image fusion software, which allow simple patient throughput for hybrid SPECT/CT studies. Further technological improvements such as more efficient detector technology to allow for low-radiation protocols, ultra-fast image acquisition and improved low-noise image reconstruction algorithms will be instrumental to further promote hybrid SPECT/CT in research and clinical practice. (orig.)

  3. State of the art in marketing hospital foodservice departments.

    Science.gov (United States)

    Pickens, C W; Shanklin, C W

    1985-11-01

    The purposes of this study were to identify the state of the art relative to the utilization of marketing techniques within hospital foodservice departments throughout the United States and to determine whether any relationships existed between the degree of utilization of marketing techniques and selected demographic characteristics of the foodservice administrators and/or operations. A validated questionnaire was mailed to 600 randomly selected hospital foodservice administrators requesting information related to marketing in their facilities. Forty-five percent of the questionnaires were returned and analyzed for frequency of response and significant relationship between variables. Chi-square was used for nominal data and Spearman rho for ranked data. Approximately 73% of the foodservice administrators stated that marketing was extremely important in the success of a hospital foodservice department. Respondents (79%) further indicated that marketing had become more important in their departments in the past 2 years. Departmental records, professional journals, foodservice suppliers, observation, and surveys were the sources most often used to obtain marketing data, a responsibility generally assumed by the foodservice director (86.2%). Merchandising, public relations, and word-of-mouth reputation were regarded as the most important aspects of marketing. Increased sales, participation, good will, departmental recognition, and employee satisfaction were used most frequently to evaluate the success of implemented marketing techniques. Marketing audits as a means of evaluating the success of marketing were used to a limited extent by the respondents.

  4. State-of-the-art Model M-2 Maintenance System

    International Nuclear Information System (INIS)

    Herndon, J.N.; Martin, H.L.; Satterlee, P.E. Jr.; Jelatis, D.G.; Jennrich, C.E.

    1984-04-01

    The Model M-2 Maintenance System is part of an ongoing program within the Consolidated Fuel Reprocessing Program (CFRP) at Oak Ridge National Laboratory (ORNL) to improve remote manipulation technology for future nuclear fuel reprocessing and other remote applications. Techniques, equipment, and guidelines which can improve the efficiency of remote maintenance are being developed. The Model M-2 Maintenance System, installed in the Integrated Equipment Test (IET) Facility at ORNL, provides a complete, integrated remote maintenance system for the demonstration and development of remote maintenance techniques. The system comprises a pair of force-reflecting servomanipulator arms, television viewing, lighting, and auxiliary lifting capabilities, thereby allowing manlike maintenance operations to be executed remotely within the remote cell mockup area in the IET. The Model M-2 Maintenance System incorporates an upgraded version of the proven Central Research Laboratories' Model M servomanipulator. Included are state-of-the-art brushless dc servomotors for improved performance, remotely removable wrist assemblies, geared azimuth drive, and a distributed microprocessor-based digital control system. 5 references, 8 figures

  5. Discovery Mondays "State-of-the-art technologies for precision"

    CERN Multimedia

    2007-01-01

    Ceramic plate drilled with high precision in CERN’s workshop. The diameter of each hole is only 0.02 millimetres, comparable to the diameter of a hair.Scientists have to be infinitely precise to study the infinitely small. Thus, even though the LHC is the world’s largest accelerator, it has to be aligned to within a tenth of a millimetre. The detectors weigh several thousand tonnes but are capable of detecting the tiniest vibration of the Earth. Join us at the next Discovery Monday to find out about CERN’s state-of-the-art tools for achieving the degrees of resolution required in the field of particle physics. Don’t miss this opportunity to discover the world of precision! The event will be conducted in FrenchCome along to the Microcosm (Reception Building 33, Meyrin site) on Monday 5 November from 7.30 p.m. to 9.00 p.m. Entrance Free http://www.cern.ch/LundisDecouverte/

  6. Technology in precision viticulture: a state of the art review

    Directory of Open Access Journals (Sweden)

    Matese A

    2015-05-01

    Full Text Available Alessandro Matese,1 Salvatore Filippo Di Gennaro1,2 1Institute of Biometeorology, National Research Council (IBIMET-CNR, Florence, Italy; 2Department of Agricultural, Food and Environmental Sciences, University of Perugia, Perugia, Italy Abstract: Precision viticulture aims to maximize the oenological potential of vineyards. This is especially true in regions where the high quality standards of wine production justify the adoption of site-specific management practices to simultaneously increase both quality and yield. The introduction of new technologies for supporting vineyard management allows the efficiency and quality of production to be improved and, at the same time, reduces the environmental impact. The rapid evolution of information communication technologies and geographical science offers enormous potential for the development of optimized solutions for distributed information for precision viticulture. Recent technological developments have allowed useful tools to be elaborated that help in the monitoring and control of many aspects of vine growth. Precision viticulture thus seeks to exploit the widest range of available observations to describe the vineyard spatial variability with high resolution, and provide recommendations to improve management efficiency in terms of quality, production, and sustainability. This review presents a brief outline of state of the art of technologies in precision viticulture. It is divided in two sections, the first focusing on monitoring technologies such as geolocating and remote and proximal sensing; the second focuses on variable-rate technologies and the new agricultural robots. Keywords: remote sensing, proximal sensing, variable-rate technology, robot 

  7. Stored energy calculation: the state of the art

    International Nuclear Information System (INIS)

    Cunningham, M.E.; Lanning, D.D.; Olsen, A.R.; Williford, R.E.; Hann, C.R.

    1978-05-01

    The report is the result of an investigation to determine the current state of the art of fuel temperature, gap conductance, and stored energy calculations. Major emphasis was placed on the propagation of input and model uncertainties. To support this study a comparison was made to the observed variability of experimental data for fuel centerline temperature and gap conductance values. The uncertainty analysis was performed by identifying major thermal models and collecting them into an abstract of a thermal performance code. Uncertainties in the calculations were determined using the method of propagation of uncertainties with a first order Taylor series approximation to the nonlinear functions. Output uncertainty results are presented for the beginning of fuel life, the end of life, and throughout a typical power history. Also presented is an influence and importance analysis for the input parameters. It is concluded that the relative uncertainty in stored energy is approximately +-20 percent at beginning of fuel life, and increases to +-25 to 40 percent contact. The foregoing are 3 sigma (99.9 percent) confidence intervals. The most important contributors to stored energy uncertainty are linear heat rating and fuel thermal conductivity

  8. Fabricating biomedical origami: a state-of-the-art review.

    Science.gov (United States)

    Johnson, Meredith; Chen, Yue; Hovet, Sierra; Xu, Sheng; Wood, Bradford; Ren, Hongliang; Tokuda, Junichi; Tse, Zion Tsz Ho

    2017-11-01

    Origami-based biomedical device design is an emerging technology due to its ability to be deployed from a minimal foldable pattern to a larger volume. This paper aims to review state-of-the-art origami structures applied in the medical device field. Publications and reports of origami structure related to medical device design from the past 10 years are reviewed and categorized according to engineering specifications, including the application field, fabrication material, size/volume, deployment method, manufacturability, and advantages. This paper presents an overview of the biomedical applications of devices based on origami structures, including disposable sterilization covers, cardiac catheterization, stent grafts, encapsulation and microsurgery, gastrointestinal microsurgery, laparoscopic surgical grippers, microgrippers, microfluidic devices, and drug delivery. Challenges in terms of materials and fabrication, assembly, modeling and computation design, and clinical adoptability are discussed at the end of this paper to provide guidance for future origami-based design in the medical device field. Concepts from origami can be used to design and develop novel medical devices. Origami-based medical device design is currently progressing, with researchers improving design methods, materials, fabrication techniques, and folding efficiency.

  9. Modular robotics overview of the 'state of the art'

    International Nuclear Information System (INIS)

    Kress, R.L.; Jansen, J.F.; Hamel, W.R.

    1996-08-01

    The design of a robotic arm processing modular components and reconfigurable links is the general goal of a modular robotics development program. The impetus behind the pursuit of modular design is the remote engineering paradigm of improved reliability and availability provided by the ability to remotely maintain and repair a manipulator operating in a hazardous environment by removing and replacing worn or failed modules. Failed components can service off- line and away from hazardous conditions. The desire to reconfigure an arm to perform different tasks is also an important driver for the development of a modular robotic manipulator. In order to bring to fruition a truly modular manipulator, an array of technical challenges must be overcome. These range from basic mechanical and electrical design considerations such as desired kinematics, actuator types, and signal and transmission types and routings, through controls issues such as the need for control algorithms capable of stable free space and contact control, to computer and sensor design issues like consideration of the use of embedded processors and redundant sensors. This report presents a brief overview of the state of the art of technical issues relevant of modular robotic arm design. The focus is on breadth of coverage, rather than depth, in order to provide a reference frame for future development

  10. State-of-the-Art Beta Detection and Dosimetry

    International Nuclear Information System (INIS)

    David M. Hamby

    2008-01-01

    The research funded by this NEER grant establishes the framework for a detailed understanding of the challenges in beta dosimetry, especially in the presence of a mixed radiation field. The work also stimulated the thinking of the research group which will lead to new concepts in digital signal processing to allow collection of detection signals and real-time analysis such that simultaneous beta and gamma spectroscopy can take place. The work described herein (with detail in the many publications that came out of this research) was conducted in a manner that provided dissertation and thesis topics for three students, one of whom was completely funded by this grant. The overall benefit of the work came in the form of a dramatic shift in signal processing that is normally conducted in analog pulse shape analysis. Analog signal processing was shown not to be feasible for this type of work; digital signal processing was a must. This, in turn, led the research team to a new understanding of pulse analysis, one in which expands the state-of-the-art in simultaneous beta and gamma spectroscopy with a single detector

  11. State of the art of solid state dosimetry

    International Nuclear Information System (INIS)

    Souza, Susana O.; Yamamoto, Takayoshi; D'Errico, Francesco

    2014-01-01

    Passive solid-state detectors still dominate the personal dosimetry field. This article provides state of the art in this field and summarizes the most recent works presented on TL, OSL and RPL during the 17th International Conference on Solid State Dosimetry held in Recife in September 2013. The Article contains in particular the techniques Thermoluminescence (TL), Optically Stimulated Luminescence (OSL), radio photoluminescence (RPL). Thermoluminescence has the biggest advantage of the wide availability of commercial materials for dosimetry, and the nature tissue-equivalent of several of these materials. The limitation of the TL dosimetry presents fading luminance signal and the need for high temperatures to obtain the signal. The Optically Stimulated Luminescence has the advantages of high sensitivity, the possibility of multiple reading, while its limit is the need to use response compensating filters in addition to the high cost of equipment and dosimeters still restricted very few options trading . The radio photoluminescence has a reading that is completely non-destructive, but their dosimeters present lack of tissue-equivalent and a high cost. Presents the details of the techniques and the advantages and limitations of each of these will be discussed

  12. State-of-the-Art Prescriptive Criteria Weight Elicitation

    Directory of Open Access Journals (Sweden)

    Mona Riabacke

    2012-01-01

    Full Text Available Comparatively few of the vast amounts of decision analytical methods suggested have been widely spread in actual practice. Some approaches have nevertheless been more successful in this respect than others. Quantitative decision making has moved from the study of decision theory founded on a single criterion towards decision support for more realistic decision-making situations with multiple, often conflicting, criteria. Furthermore, the identified gap between normative and descriptive theories seems to suggest a shift to more prescriptive approaches. However, when decision analysis applications are used to aid prescriptive decision-making processes, additional demands are put on these applications to adapt to the users and the context. In particular, the issue of weight elicitation is crucial. There are several techniques for deriving criteria weights from preference statements. This is a cognitively demanding task, subject to different biases, and the elicited values can be heavily dependent on the method of assessment. There have been a number of methods suggested for assessing criteria weights, but these methods have properties which impact their applicability in practice. This paper provides a survey of state-of-the-art weight elicitation methods in a prescriptive setting.

  13. The backstroke swimming start: state of the art.

    Science.gov (United States)

    de Jesus, Karla; de Jesus, Kelly; Fernandes, Ricardo J; Vilas-Boas, João Paulo; Sanders, Ross

    2014-09-29

    As sprint swimming events can be decided by margins as small as .01 s, thus, an effective start is essential. This study reviews and discusses the 'state of the art' literature regarding backstroke start biomechanics from 23 documents. These included two swimming specific publications, eight peer-reviewed journal articles, three from the Biomechanics and Medicine in Swimming Congress series, eight from the International Society of Biomechanics in Sports Conference Proceedings, one from a Biomechanics Congress and one academic (PhD) thesis. The studies had diverse aims, including swimmers' proficiency levels and data collection settings. There was no single consensus for defining phase descriptions; and kinematics, kinetics and EMG approaches were implemented in laboratory settings. However, researchers face great challenges in improving methods of quantifying valid, reliable and accurate data between laboratory and competition conditions. For example, starting time was defined from the starting signal to distances as disparate as ∼5 m to 22.86 m in several studies. Due to recent rule changes, some of the research outcomes now refer to obsolete backstroke start techniques, and only a few studies considered the actual international rules. This literature review indicated that further research is required, in both laboratory and competition settings focusing on the combined influences of the current rules and block configuration on backstroke starting performances.

  14. Nanomedicine applications in women's health: state of the art.

    Science.gov (United States)

    Lloyd-Parry, Oliver; Downing, Charlotte; Aleisaei, Eisa; Jones, Celine; Coward, Kevin

    2018-01-01

    State-of-the-art applications of nanomedicine have the potential to revolutionize the diagnosis, prevention, and treatment of a range of conditions and diseases affecting women's health. In this review, we provide a synopsis of potential applications of nanomedicine in some of the most dominant fields of women's health: mental health, sexual health, reproductive medicine, oncology, menopause-related conditions and dementia. We explore published studies arising from in vitro and in vivo experiments, and clinical trials where available, to reveal novel and highly promising therapeutic applications of nanomedicine in these fields. For the first time, we summarize the growing body of evidence relating to the use of nanomaterials as experimental tools for the detection, prevention, and treatment of significant diseases and conditions across the life course of a cisgender woman, from puberty to menopause; revealing the far-reaching and desirable theoretical impact of nanomedicine across different medical disciplines. We also present an overview of potential concerns regarding the therapeutic applications of nanomedicine and the factors currently restricting the growth of applied nanomedicine.

  15. Clinical reappraisal and state of the art of nephropexy.

    Science.gov (United States)

    Mogorovich, Andrea; Selli, Cesare; De Maria, Maurizio; Manassero, Francesca; Durante, Jacopo; Urbani, Lucio

    2018-04-01

    The diffusion of minimally invasive techniques for renal surgery has prompted a renewed interest in nephropexy which is indicated to prevent nephroptosis in symptomatic patients and to mobilize the upper ureter downward in order to bridge a ureteral defect. Recent publications have been reviewed to present the state of the art of the diagnosis and management of these two challenging conditions and to try to foresee the next steps. The evaluation of patients with mobile kidney can be made relying on diagnostic criteria such as ultrasound with color Doppler and measurement of resistive index, conventional upright X-ray frames after a supine uro-computerized tomography scan and both static and dynamic nuclear medicine scans, always with evaluation in the sitting or erect position. Laparoscopic nephropexy emerges as the current treatment option combining both objectively controlled repositioning of the kidney and resolution of symptoms with minimal invasiveness, low morbidity, and short hospital stay. The use of robotics is presently limited by its higher cost, but may increase in the future. Downward renal mobilization and nephropexy is a safe and versatile technique which has been adopted as a unique strategy or more often in combination with other surgical maneuvers in order to cope with complex ureteral reconstruction.

  16. Intracytoplasmic sperm injection: state of the art in humans.

    Science.gov (United States)

    Palermo, G D; O'Neill, C L; Chow, S; Cheung, S; Parrella, A; Pereira, N; Rosenwaks, Z

    2017-12-01

    Among infertile couples, 25% involve both male and female factors, while male factor alone accounts for another 25% due to oligo-, astheno-, teratozoospermia, a combination of the three, or even a complete absence of sperm cells in the ejaculate and can lead to a poor prognosis even with the help of assisted reproductive technology (ART). Intracytoplasmic sperm injection (ICSI) has been with us now for a quarter of a century and in spite of the controversy generated since its inception, it remains in the forefront of the techniques utilized in ART. The development of ICSI in 1992 has drastically decreased the impact of male factor, resulting in millions of pregnancies worldwide for couples who, without ICSI, would have had little chance of having their own biological child. This review focuses on the state of the art of ICSI regarding utility of bioassays that evaluate male factor infertility beyond the standard semen analysis and describes the current application and advances in regard to ICSI, particularly the genetic and epigenetic characteristics of spermatozoa and their impact on reproductive outcome. © 2017 Society for Reproduction and Fertility.

  17. A state of the art on metallic fuel technology development

    International Nuclear Information System (INIS)

    Hwang, Woan; Kang, Hee Young; Nam, Cheol; Kim, Jong Oh

    1997-01-01

    Since worldwide interest turned toward ceramic fuels before the full potential of metallic fuel could be achieved in the late 1960's, the development of metallic fuels continued throughout the 1970's at ANL's experimental breeder reactor II (EBR-II) because EBR-II continued to be fueled with the metallic uranium-fissium alloy, U-5Fs. During this decade the performance limitations of metallic fuel were satisfactorily resolved resolved at EBR-II. The concept of the IFR developed at ANL since 1984. The technical feasibility had been demonstrated and the technology database had been established to support its practicality. One key features of the IFR is that the fuel is metallic, which brings pronounced benefits over oxide in improved inherent safety and lower processing costs. At the outset of the 1980's, it appeared that metallic fuels are recognized as a professed viable option with regard to safety, integral fuel cycle, waste minimization and deployment economics. This paper reviews the key advances in the last score and summarizes the state-of the art on metallic fuel technology development. (author). 29 refs., 1 tab

  18. A state of the art on metallic fuel technology development

    Energy Technology Data Exchange (ETDEWEB)

    Hwang, Woan; Kang, Hee Young; Nam, Cheol; Kim, Jong Oh [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

    1997-12-31

    Since worldwide interest turned toward ceramic fuels before the full potential of metallic fuel could be achieved in the late 1960`s, the development of metallic fuels continued throughout the 1970`s at ANL`s experimental breeder reactor II (EBR-II) because EBR-II continued to be fueled with the metallic uranium-fissium alloy, U-5Fs. During this decade the performance limitations of metallic fuel were satisfactorily resolved resolved at EBR-II. The concept of the IFR developed at ANL since 1984. The technical feasibility had been demonstrated and the technology database had been established to support its practicality. One key features of the IFR is that the fuel is metallic, which brings pronounced benefits over oxide in improved inherent safety and lower processing costs. At the outset of the 1980`s, it appeared that metallic fuels are recognized as a professed viable option with regard to safety, integral fuel cycle, waste minimization and deployment economics. This paper reviews the key advances in the last score and summarizes the state-of the art on metallic fuel technology development. (author). 29 refs., 1 tab.

  19. State-of-the-art report on piping fracture mechanics

    Energy Technology Data Exchange (ETDEWEB)

    Wilkowski, G.M.; Olson, R.J.; Scott, P.M. [Battelle, Columbus, OH (United States)

    1998-01-01

    This report is an in-depth summary of the state-of-the-art in nuclear piping fracture mechanics. It represents the culmination of 20 years of work done primarily in the US, but also attempts to include important aspects from other international efforts. Although the focus of this work was for the nuclear industry, the technology is also applicable in many cases to fossil plants, petrochemical/refinery plants, and the oil and gas industry. In compiling this detailed summary report, all of the equations and details of the analysis procedure or experimental results are not necessarily included. Rather, the report describes the important aspects and limitations, tells the reader where he can go for further information, and more importantly, describes the accuracy of the models. Nevertheless, the report still contains over 150 equations and over 400 references. The main sections of this report describe: (1) the evolution of piping fracture mechanics history relative to the developments of the nuclear industry, (2) technical developments in stress analyses, material property aspects, and fracture mechanics analyses, (3) unresolved issues and technically evolving areas, and (4) a summary of conclusions of major developments to date.

  20. Antiphospholipid Syndrome during pregnancy: the state of the art

    Science.gov (United States)

    Di Prima, Fosca A. F.; Valenti, Oriana; Hyseni, Entela; Giorgio, Elsa; Faraci, Marianna; Renda, Eliana; De Domenico, Roberta; Monte, Santo

    2011-01-01

    Obstetric complications are the hallmark of antiphospholipid syndrome. Recurrent miscarriage, early delivery, oligohydramnios, prematurity, intrauterine growth restriction, fetal distress, fetal or neonatal thrombosis, pre-eclampsia/eclampsia, HELLP syndrome, arterial or venous thrombosis and placental insufficiency are the most severe APS-related complication for pregnant women. Antiphospholipid antibodies promote activation of endothelial cells, monocytes and platelets, causing an overproduction of tissue factor and thromboxane A2. Complement activation might have a central pathogenetic role. These factors, associated with the typical changes in the hemostatic system during normal pregnancy, result in a hypercoagulable state. This is responsible of thrombosis that is presumed to provoke many of the pregnancy complications associated with APS. Obstetric care is based on combined medical-obstetric high-risk management and treatment with the association between aspirin and heparin. This review aims to deter- mine the current state of the art of APS by investigating the knowledge achievements of recent years, to provide the most appropriate diagnostic and therapeutic management for pregnant women suffering from this syndrome. PMID:22439075

  1. State-of-the-art report on piping fracture mechanics

    International Nuclear Information System (INIS)

    Wilkowski, G.M.; Olson, R.J.; Scott, P.M.

    1998-01-01

    This report is an in-depth summary of the state-of-the-art in nuclear piping fracture mechanics. It represents the culmination of 20 years of work done primarily in the US, but also attempts to include important aspects from other international efforts. Although the focus of this work was for the nuclear industry, the technology is also applicable in many cases to fossil plants, petrochemical/refinery plants, and the oil and gas industry. In compiling this detailed summary report, all of the equations and details of the analysis procedure or experimental results are not necessarily included. Rather, the report describes the important aspects and limitations, tells the reader where he can go for further information, and more importantly, describes the accuracy of the models. Nevertheless, the report still contains over 150 equations and over 400 references. The main sections of this report describe: (1) the evolution of piping fracture mechanics history relative to the developments of the nuclear industry, (2) technical developments in stress analyses, material property aspects, and fracture mechanics analyses, (3) unresolved issues and technically evolving areas, and (4) a summary of conclusions of major developments to date

  2. Ecological effects assessment: requirements vs state-of-the-art

    International Nuclear Information System (INIS)

    McKenzie, D.H.; Thomas, J.M.; Eberhardt, L.L.

    1981-05-01

    Concerns for environmental quality, the ecologist's understanding of ecosystems, and the ability to quantitatively sample and evaluate hypotheses have contributed to current requirements and the state-of-the-art in ecological effects assessments in refard to nuclear power plants. The current cooling system approaches, data collection programs, and ecological effects assessments reflect these contributions. Over a decade of experience provides the basis for a timely review and evaluation of current proactice. The magnitude of economic and environmental resources being committed to cooling system alternatives mandates that the decision-making process result in as many optimal choices as possible. In addition, the resources being devoted to environmental data collection and integration provide considerable motivation for providing meaningful input to the decision-making process. It is maintained that the input should be as quantitative and as free from subjective content as is reasonably possible. An alternative viewpoint suggests that the past several decades of experience be considered but a first step, and the current task to be one of designing a second step

  3. Processing emotional body expressions: state-of-the-art.

    Science.gov (United States)

    Enea, Violeta; Iancu, Sorina

    2016-10-01

    Processing emotional body expressions has become recently an important topic in affective and social neuroscience along with the investigation of facial expressions. The objective of the study is to review the literature on emotional body expressions in order to discuss the current state of knowledge on this topic and identify directions for future research. The following electronic databases were searched: PsychINFO, Ebsco, ERIC, ProQuest, Sagepub, and SCOPUS using terms such as "body," "bodily expression," "body perception," "emotions," "posture," "body recognition" and combinations of them. The synthesis revealed several research questions that were addressed in neuroimaging, electrophysiological and behavioral studies. Among them, one important question targeted the neural mechanisms of emotional processing of body expressions to specific subsections regarding the time course for the integration of emotional signals from face and body, as well as the role of context in the perception of emotional signals. Processing bodily expression of emotion is similar to processing facial expressions, and the holistic processing is extended to the whole person. The current state-of-the-art in processing emotional body expressions may lead to a better understanding of the underlying neural mechanisms of social behavior. At the end of the review, suggestions for future research directions are presented.

  4. Non-animal sensitization testing: state-of-the-art.

    Science.gov (United States)

    Vandebriel, Rob J; van Loveren, Henk

    2010-05-01

    Predictive tests to identify the sensitizing properties of chemicals are carried out using animals. In the European Union timelines for phasing out many standard animal tests were established for cosmetics. Following this policy, the new European Chemicals Legislation (REACH) favors alternative methods, if validated and appropriate. In this review the authors aim to provide a state-of-the art overview of alternative methods (in silico, in chemico, and in vitro) to identify contact and respiratory sensitizing capacity and in some occasions give a measure of potency. The past few years have seen major advances in QSAR (quantitative structure-activity relationship) models where especially mechanism-based models have great potential, peptide reactivity assays where multiple parameters can be measured simultaneously, providing a more complete reactivity profile, and cell-based assays. Several cell-based assays are in development, not only using different cell types, but also several specifically developed assays such as three-dimenionally (3D)-reconstituted skin models, an antioxidant response reporter assay, determination of signaling pathways, and gene profiling. Some of these assays show relatively high sensitivity and specificity for a large number of sensitizers and should enter validation (or are indeed entering this process). Integrating multiple assays in a decision tree or integrated testing system is a next step, but has yet to be developed. Adequate risk assessment, however, is likely to require significantly more time and efforts.

  5. Management of infected pancreatic necrosis: state of the art

    Directory of Open Access Journals (Sweden)

    Roberto Rasslan

    Full Text Available ABSTRACT Pancreatic necrosis occurs in 15% of acute pancreatitis. The presence of infection is the most important factor in the evolution of pancreatitis. The diagnosis of infection is still challenging. Mortality in infected necrosis is 20%; in the presence of organic dysfunction, mortality reaches 60%. In the last three decades, there has been a real revolution in the treatment of infected pancreatic necrosis. However, the challenges persist and there are many unsolved questions: antibiotic treatment alone, tomography-guided percutaneous drainage, endoscopic drainage, video-assisted extraperitoneal debridement, extraperitoneal access, open necrosectomy? A step up approach has been proposed, beginning with less invasive procedures and reserving the operative intervention for patients in which the previous procedure did not solve the problem definitively. Indication and timing of the intervention should be determined by the clinical course. Ideally, the intervention should be done only after the fourth week of evolution, when it is observed a better delimitation of necrosis. Treatment should be individualized. There is no procedure that should be the first and best option for all patients. The objective of this work is to critically review the current state of the art of the treatment of infected pancreatic necrosis.

  6. State-of-the-Art Beta Detection and Dosimetry

    Energy Technology Data Exchange (ETDEWEB)

    David M. Hamby

    2008-08-15

    The research funded by this NEER grant establishes the framework for a detailed understanding of the challenges in beta dosimetry, especially in the presence of a mixed radiation field. The work also stimulated the thinking of the research group which will lead to new concepts in digital signal processing to allow collection of detection signals and real-time analysis such that simultaneous beta and gamma spectroscopy can take place. The work described herein (with detail in the many publications that came out of this research) was conducted in a manner that provided dissertation and thesis topics for three students, one of whom was completely funded by this grant. The overall benefit of the work came in the form of a dramatic shift in signal processing that is normally conducted in analog pulse shape analysis. Analog signal processing was shown not to be feasible for this type of work; digital signal processing was a must. This, in turn, led the research team to a new understanding of pulse analysis, one in which expands the state-of-the-art in simultaneous beta and gamma spectroscopy with a single detector.

  7. State of the art on periphyton knowledge in Colombia

    International Nuclear Information System (INIS)

    Montoya Moreno, Yimmy; Aguirre R, Nestor

    2013-01-01

    Periphyton is a component of aquatic communities, composed by microbiota adhered to different substrates; plays a fundamental role in matter, energy and information transferences trough food webs and its study is important both from ecology, to understand ecosystems, as from environmental points of view, as periphyton is a good indicator of environmental processes and conditions, for instance water quality, in those ecosystems. Periphyton research is complex; even periphyton definition is still controversial. In addition to that, the variety of methodologies for comprehensive study, the diversity of peri phytic matrix architectures, the diversity of ecosystems and the absence of taxonomic schools in the country, are causing that few works are being published on the subject, which increases the value and importance of the work outlined in this review. The aim of this paper is to present the state of the art in research on periphyton in Colombia, analyzing different lines of research that has been developed and their progress. In order to do this, we examined 84 papers available to the authors. Most studies surveyed in this study (90%) correspond to the study of phycoperiphyton; the remaining 10% included both components of periphyton; one paper was dedicated exclusively to zooperiphyton. Only 10.5% of investigations (8 papers) have been dedicated to detailed taxonomic study; other publications study the structure and dynamics of the periphytic community.

  8. Desiccant cooling: State-of-the-art assessment

    Energy Technology Data Exchange (ETDEWEB)

    Pesaran, A.A.; Penney, T.R.; Czanderna, A.W.

    1992-10-01

    The objectives of this document are to present an overview of the work accomplished to date on desiccant cooling to provide assessment of the state of the art of desiccant cooling technology in the field of desiccant material dehumidifier components, desiccant systems, and models. The report also discusses the factors that affect the widespread acceptance of desiccant cooling technology. This report is organized as follows. First, a basic description and historical overview of desiccant cooling technology is provided. Then, the recent research and development (R D) program history (focusing on DOE's funded efforts) is discussed. The status of the technology elements (materials, components, systems) is discussed in detail and a preliminary study on the energy impact of desiccant technology is presented. R D needs for advancing the technology in the market are identified. The National Renewable Energy Laboratory's unique desiccant test facilities and their typical outputs are described briefly. Finally, the results of a comprehensive literature search on desiccant cooling are presented in a bibliography. The bibliography contains approximately 900 citations on desiccant cooling.

  9. Desiccant cooling: State-of-the-art assessment

    Energy Technology Data Exchange (ETDEWEB)

    Pesaran, A.A.; Penney, T.R.; Czanderna, A.W.

    1992-10-01

    The objectives of this document are to present an overview of the work accomplished to date on desiccant cooling to provide assessment of the state of the art of desiccant cooling technology in the field of desiccant material dehumidifier components, desiccant systems, and models. The report also discusses the factors that affect the widespread acceptance of desiccant cooling technology. This report is organized as follows. First, a basic description and historical overview of desiccant cooling technology is provided. Then, the recent research and development (R&D) program history (focusing on DOE`s funded efforts) is discussed. The status of the technology elements (materials, components, systems) is discussed in detail and a preliminary study on the energy impact of desiccant technology is presented. R&D needs for advancing the technology in the market are identified. The National Renewable Energy Laboratory`s unique desiccant test facilities and their typical outputs are described briefly. Finally, the results of a comprehensive literature search on desiccant cooling are presented in a bibliography. The bibliography contains approximately 900 citations on desiccant cooling.

  10. A State-of-the-Art Review of Cloud Forensics

    Directory of Open Access Journals (Sweden)

    Sameera Abdulrahman Almulla

    2014-12-01

    Full Text Available Cloud computing and digital forensics are emerging fields of technology. Unlike traditional digital forensics where the target environment can be almost completely acquired, isolated and can be under the investigators control; in cloud environments, the distribution of computation and storage poses unique and complex challenges to the investigators.Recently, the term "cloud forensics" has an increasing presence in the field of digital forensics. In this state-of-the-art review, we included the most recent research efforts that used "cloud forensics" as a keyword and then classify the literature in to three dimensions, (1 survey-based, (2 technology-based and (3 forensics procedural-based.We discuss widely accepted international standard bodies and their efforts to cope with the current trend of cloud forensics. Our aim is not only to reference related work based on the discussed dimensions, but also to analyze them and generate a mind map that will help in identifying research gaps. Finally, we summarize existing digital forensics tools and, the available simulation environments that can be used for evidence acquisition, examination and cloud forensics test purposes.

  11. State of the Art: Embedding Security in Vehicles

    Directory of Open Access Journals (Sweden)

    Weimerskirch André

    2007-01-01

    Full Text Available For new automotive applications and services, information technology (IT has gained central importance. IT-related costs in car manufacturing are already high and they will increase dramatically in the future. Yet whereas safety and reliability have become a relatively well-established field, the protection of vehicular IT systems against systematic manipulation or intrusion has only recently started to emerge. Nevertheless, IT security is already the base of some vehicular applications such as immobilizers or digital tachographs. To securely enable future automotive applications and business models, IT security will be one of the central technologies for the next generation of vehicles. After a state-of-the-art overview of IT security in vehicles, we give a short introduction into cryptographic terminology and functionality. This contribution will then identify the need for automotive IT security while presenting typical attacks, resulting security objectives, and characteristic constraints within the automotive area. We will introduce core security technologies and relevant security mechanisms followed by a detailed description of critical vehicular applications, business models, and components relying on IT security. We conclude our contribution with a detailed statement about challenges and opportunities for the automotive IT community for embedding IT security in vehicles.

  12. State of the Art: Embedding Security in Vehicles

    Directory of Open Access Journals (Sweden)

    André Weimerskirch

    2007-06-01

    Full Text Available For new automotive applications and services, information technology (IT has gained central importance. IT-related costs in car manufacturing are already high and they will increase dramatically in the future. Yet whereas safety and reliability have become a relatively well-established field, the protection of vehicular IT systems against systematic manipulation or intrusion has only recently started to emerge. Nevertheless, IT security is already the base of some vehicular applications such as immobilizers or digital tachographs. To securely enable future automotive applications and business models, IT security will be one of the central technologies for the next generation of vehicles. After a state-of-the-art overview of IT security in vehicles, we give a short introduction into cryptographic terminology and functionality. This contribution will then identify the need for automotive IT security while presenting typical attacks, resulting security objectives, and characteristic constraints within the automotive area. We will introduce core security technologies and relevant security mechanisms followed by a detailed description of critical vehicular applications, business models, and components relying on IT security. We conclude our contribution with a detailed statement about challenges and opportunities for the automotive IT community for embedding IT security in vehicles.

  13. Egg Yolk Antibodies, State of the Art and Future Prospects.

    Science.gov (United States)

    Schade, Rüdiger; Hlinak, Andreas

    1996-01-01

    Immunization of chickens and extraction of antibodies from egg yolk belongs to the alternative methods since the animals suffering is reduced by non-invasive antibody-sampling. Also, the number of animals needed to produce a certain amount of antibody can be reduced since chickens produce a significant higher antibody quantity than rabbits. Despite its several advantages this technology (IgY-technology) is rather scarcely used. Traditional behavior as well as limited or no information at all may hamper a broader acceptance at present. However, significant arguments exist in chicken housing, the choice of appropriate IgY-extraction methods and a lack of information regarding the use of IgY-antibodies. This paper intends to give a short introduction in the IgY-technology, to briefly discuss the state of the art and to inform on recent developments and discussions in this field. The suitability of IgY for special fields of application (as a result of the structural differences between IgY and IgG) is emphasized (e.g. assays combining IgG and IgY, immunization of chickens against highly conserved anti-genes). In addition, it is stressed that the IgY-technology as an alternative method can particularly integrate requirements of animal protection (reduce, replace, refine), science (characteristics of avian immune system and resulting properties of IgY) and economy (amount of IgY produced from one chicken).

  14. Origin, state of the art and some prospects of the diamond CVD

    CERN Document Server

    Spitsyn, B V; Alexenko, A E

    2000-01-01

    A short review on the diamond CVD origin, together with its state of the art and some prospects was given. New hybrid methods of the diamond CVD permit to gain 1.2 to 6 times of growth rate in comparison with ordinary diamond CVD's. Recent results on n-type diamond film synthesis through phosphorus doping in the course of the CVD process are briefly discussed. In comparison with high-pressure diamond synthesis, the CVD processes open new facets of the diamond as ultimate crystal for science and technology evolution. It was stressed that, mainly on the basis of new CVDs of diamond, the properties of natural diamond are not only reproduced, but can be surpassed. As examples, mechanical (fracture resistance), physical (thermal conductivity), and chemical (oxidation stability) properties are mentioned. Some present issues in the field are considered.

  15. State-of-the-Art Materials for Ultrasound-Triggered Drug Delivery

    Science.gov (United States)

    Sirsi, Shashank; Borden, Mark

    2014-01-01

    Ultrasound is a unique and exciting theranostic modality that can be used to track drug carriers, trigger drug release and improve drug deposition with high spatial precision. In this review, we briefly describe the mechanisms of interaction between drug carriers and ultrasound waves, including cavitation, streaming and hyperthermia, and how those interactions can promote drug release and tissue uptake. We then discuss the rational design of some state-of-the-art materials for ultrasound-triggered drug delivery and review recent progress for each drug carrier, focusing on the delivery of chemotherapeutic agents such as doxorubicin. These materials include nanocarrier formulations, such as liposomes and micelles, designed specifically for ultrasound-triggered drug release, as well as microbubbles, microbubble-nanocarrier hybrids, microbubble-seeded hydrogels and phase-change agents. PMID:24389162

  16. Wind power forecasting : state-of-the-art 2009.

    Energy Technology Data Exchange (ETDEWEB)

    Monteiro, C.; Bessa, R.; Miranda, V.; Botterud, A.; Wang, J.; Conzelmann, G.; Decision and Information Sciences; INESC Porto

    2009-11-20

    uncertainty in wind power and to more efficiently operate power systems with large wind power penetrations. Moreover, in a market environment, the wind power contribution to the generation portofolio becomes important in determining the daily and hourly prices, as variations in the estimated wind power will influence the clearing prices for both energy and operating reserves. With the increasing penetration of wind power, WPF is quickly becoming an important topic for the electric power industry. System operators (SOs), generating companies (GENCOs), and regulators all support efforts to develop better, more reliable and accurate forecasting models. Wind farm owners and operators also benefit from better wind power prediction to support competitive participation in electricity markets against more stable and dispatchable energy sources. In general, WPF can be used for a number of purposes, such as: generation and transmission maintenance planning, determination of operating reserve requirements, unit commitment, economic dispatch, energy storage optimization (e.g., pumped hydro storage), and energy trading. The objective of this report is to review and analyze state-of-the-art WPF models and their application to power systems operations. We first give a detailed description of the methodologies underlying state-of-the-art WPF models. We then look at how WPF can be integrated into power system operations, with specific focus on the unit commitment problem.

  17. Hydrogen storage: state-of-the-art and future perspective

    International Nuclear Information System (INIS)

    Tzimas, E.; Filiou, C.; Peteves, S.D.; Veyret, J.B.

    2003-01-01

    The EU aims at establishing a sustainable energy supply, able to provide affordable and clean energy without increasing green house gas emissions. Hydrogen and fuel cells are seen by many as key energy system solutions for the 21. century, enabling clean and efficient production of power and heat from a broad range of primary energy sources. To be effective, there is a crucial need for well-coordinated research, development and deployment at European Level. The particular segment of hydrogen storage is one key element of the full hydrogen chain and it must meet a number of challenges before it is introduced into the global energy system. Regarding its energy characteristics, the gravimetric energy density of hydrogen is about three times higher than gasoline, but its energy content per volume is about a quarter. Therefore, the most significant problem for hydrogen (in particular for on-board vehicles) is to store sufficient -amounts of hydrogen. The volumetric energy density of hydrogen can be increased by compression or liquefaction which are both the most mature technologies. Still the energy required for both compression and liquefaction is one element to be properly assessed in considering the different pathways in particular for distribution. As far as on-board vehicle storage is concerned all possible options (compressed, liquid, metal hydrides and porous structures) have their own advantages and disadvantages with respect to weight, volume, energy efficiency, refuelling times, cost and safety aspects. To address these problems, long-term commitments to scientific excellence in research, coupled with co-ordination between the many different stakeholders, is required. In the current state-of-the-art in hydrogen storage, no single technology satisfies all of the criteria required by manufacturers and end-users, and a large number of obstacles have to be overcome. The current hydrogen storage technologies and their associated limitations/needs for improvement

  18. State of the art in benefit-risk analysis: introduction.

    Science.gov (United States)

    Verhagen, H; Tijhuis, M J; Gunnlaugsdóttir, H; Kalogeras, N; Leino, O; Luteijn, J M; Magnússon, S H; Odekerken, G; Pohjola, M V; Tuomisto, J T; Ueland, Ø; White, B C; Holm, F

    2012-01-01

    Risk-taking is normal in everyday life if there are associated (perceived) benefits. Benefit-Risk Analysis (BRA) compares the risk of a situation to its related benefits and addresses the acceptability of the risk. Over the past years BRA in relation to food and food ingredients has gained attention. Food, and even the same food ingredient, may confer both beneficial and adverse effects. Measures directed at food safety may lead to suboptimal or insufficient levels of ingredients from a benefit perspective. In BRA, benefits and risks of food (ingredients) are assessed in one go and may conditionally be expressed into one currency. This allows the comparison of adverse and beneficial effects to be qualitative and quantitative. A BRA should help policy-makers to make more informed and balanced benefit-risk management decisions. Not allowing food benefits to occur in order to guarantee food safety is a risk management decision much the same as accepting some risk in order to achieve more benefits. BRA in food and nutrition is making progress, but difficulties remain. The field may benefit from looking across its borders to learn from other research areas. The BEPRARIBEAN project (Best Practices for Risk-Benefit Analysis: experience from out of food into food; http://en.opasnet.org/w/Bepraribean) aims to do so, by working together with Medicines, Food Microbiology, Environmental Health, Economics & Marketing-Finance and Consumer Perception. All perspectives are reviewed and subsequently integrated to identify opportunities for further development of BRA for food and food ingredients. Interesting issues that emerge are the varying degrees of risk that are deemed acceptable within the areas and the trend towards more open and participatory BRA processes. A set of 6 'state of the art' papers covering the above areas and a paper integrating the separate (re)views are published in this volume. Copyright © 2011 Elsevier Ltd. All rights reserved.

  19. Biopesticides: state of the art and future opportunities.

    Science.gov (United States)

    Seiber, James N; Coats, Joel; Duke, Stephen O; Gross, Aaron D

    2014-12-03

    The use of biopesticides and related alternative management products is increasing. New tools, including semiochemicals and plant-incorporated protectants (PIPs), as well as botanical and microbially derived chemicals, are playing an increasing role in pest management, along with plant and animal genetics, biological control, cultural methods, and newer synthetics. The goal of this Perspective is to highlight promising new biopesticide research and development (R&D), based upon recently published work and that presented in the American Chemical Society (ACS) symposium "Biopesticides: State of the Art and Future Opportunities," as well as the authors' own perspectives. Although the focus is on biopesticides, included in this Perspective is progress with products exhibiting similar characteristics, namely those naturally occurring or derived from natural products. These are target specific, of low toxicity to nontarget organisms, reduced in persistence in the environment, and potentially usable in organic agriculture. Progress is being made, illustrated by the number of biopesticides and related products in the registration pipeline, yet major commercial opportunities exist for new bioherbicides and bionematicides, in part occasioned by the emergence of weeds resistant to glyphosate and the phase-out of methyl bromide. The emergence of entrepreneurial start-up companies, the U.S. Environmental Protection Agency (EPA) fast track for biopesticides, and the availability of funding for registration-related R&D for biorational pesticides through the U.S. IR-4 program provide incentives for biopesticide development, but an expanded effort is warranted both in the United States and worldwide to support this relatively nascent industry.

  20. Personalizing Medicine Through Hybrid Imaging and Medical Big Data Analysis

    Directory of Open Access Journals (Sweden)

    Laszlo Papp

    2018-06-01

    Full Text Available Medical imaging has evolved from a pure visualization tool to representing a primary source of analytic approaches toward in vivo disease characterization. Hybrid imaging is an integral part of this approach, as it provides complementary visual and quantitative information in the form of morphological and functional insights into the living body. As such, non-invasive imaging modalities no longer provide images only, but data, as stated recently by pioneers in the field. Today, such information, together with other, non-imaging medical data creates highly heterogeneous data sets that underpin the concept of medical big data. While the exponential growth of medical big data challenges their processing, they inherently contain information that benefits a patient-centric personalized healthcare. Novel machine learning approaches combined with high-performance distributed cloud computing technologies help explore medical big data. Such exploration and subsequent generation of knowledge require a profound understanding of the technical challenges. These challenges increase in complexity when employing hybrid, aka dual- or even multi-modality image data as input to big data repositories. This paper provides a general insight into medical big data analysis in light of the use of hybrid imaging information. First, hybrid imaging is introduced (see further contributions to this special Research Topic, also in the context of medical big data, then the technological background of machine learning as well as state-of-the-art distributed cloud computing technologies are presented, followed by the discussion of data preservation and data sharing trends. Joint data exploration endeavors in the context of in vivo radiomics and hybrid imaging will be presented. Standardization challenges of imaging protocol, delineation, feature engineering, and machine learning evaluation will be detailed. Last, the paper will provide an outlook into the future role of hybrid

  1. IEC planning: eight state-of-the-art principles.

    Science.gov (United States)

    Middleton, J

    1983-12-01

    Considerable experience and research has been accumulated in the last 20 years on the ways in which information/education/communication (IEC) programs can be effectively designed, implemented, and evaluated. Possibly more effort has focused on population and family planning IEC than on any other sectoral program of development communication. Several principles have emerged which, taken together, define the state of the art in the field. These principles provide a framework of experience which can guide the development of comprehensive IEC programs. They include: policy and resource assessment; audience analysis; strategy design; message research and pretesting; participation and feedback; management; evaluation; and collaboration. The nature of the national policy base for population and family planning programs will determine the goals and approaches of the IEC program. Strong policies of limitation on popultion growth lead to equally strong and pervasive IEC efforts designed to directly affect contraceptive behavior. Assessment of existing policy is an essential aspect of the design of an effective IEC program. Policies establish the rationale and boundaries for action. Population and family planning programs are concerned with some of the most intimate human behavior. Consequently, structured and sensitive audience analysis has become an integral part of the design of IEC programs. The design of communication strategy requires clearly stated objectives. Principles of human learning are used to structure information appropriately. Message research and pretesting have become integral components of the strategy design process. Small scale research on specific objectives is necessary to establish the basis for message design. Audience participation and feedback in remaining phases of program development and implementation are important. The management of an IEC program requires a specific combination of planning, flexibility, and creativity. Evaluation of program

  2. Selected examples of intelligent (micro) sensor systems: state-of-the-art and tendencies

    Science.gov (United States)

    Hauptmann, Peter R.

    2006-03-01

    The capability of intelligent sensors to have more intelligence built into them continues to drive their application in areas including automotive, aerospace and defense, industrial, intelligent house and wear, medical and homeland security. In principle it is difficult to overestimate the importance of intelligent (micro) sensors or sensor systems within advanced societies but one characteristic feature is the global market for sensors, which is now about 20 billion annually. Therefore sensors or sensor systems play a dominant role in many fields from the macro sensor in manufacturing industry down to the miniaturized sensor for medical applications. The diversity of sensors precludes a complete description of the state-of-the-art; selected examples will illustrate the current situation. MEMS (microelectromechanical systems) devices are of special interest in the context of micro sensor systems. In past the main requirements of a sensor were in terms of metrological performance. The electrical (or optical) signal produced by the sensor needed to match the measure relatively accurately. Such basic functionality is no longer sufficient. Data processing near the sensor, the extraction of more information than just the direct sensor information by signal analysis, system aspects and multi-sensor information are the new demands. A shifting can be observed away from aiming to design perfect single-function transducers and towards the utilization of system-based sensors as system components. In the ideal case such systems contain sensors, actuators and electronics. They can be realized in monolithic, hybrid or discrete form—which kind is used depends on the application. In this article the state-of-the-art of intelligent sensors or sensor systems is reviewed using selected examples. Future trends are deduced.

  3. Harvesting Robots for High-value Crops: State-of-the-art Review and Challenges Ahead

    NARCIS (Netherlands)

    Bac, C.W.; Henten, van E.; Hemming, J.; Edan, Y.

    2014-01-01

    This review article analyzes state-of-the-art and future perspectives for harvesting robots in high-value crops. The objectives were to characterize the crop environment relevant for robotic harvesting, to perform a literature review on the state-of-the-art of harvesting robots using quantitative

  4. 14 CFR 1203.403 - State-of-the-art and intelligence.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false State-of-the-art and intelligence. 1203.403... PROGRAM Guides for Original Classification § 1203.403 State-of-the-art and intelligence. A logical... available from intelligence sources is known or is available to others. It is also important to consider...

  5. 77 FR 5281 - State-of-the-Art Reactor Consequence Analyses Reports

    Science.gov (United States)

    2012-02-02

    ... NUCLEAR REGULATORY COMMISSION [Docket ID: NRC-2012-0022] State-of-the-Art Reactor Consequence... release of Draft NUREG-1935, ``State-of-the-Art Reactor Consequence Analyses (SOARCA) Report,'' for public... offsite radiological health consequences for potential severe reactor accidents for the Peach Bottom...

  6. Hydrogen from biomass: state of the art and research challenges

    Energy Technology Data Exchange (ETDEWEB)

    Milne, Thomas A; Elam, Carolyn C; Evans, Robert J

    2002-02-01

    The report was prepared for the International Energy Agency (IEA) Agreement on the Production and Utilization of Hydrogen, Task 16, Hydrogen from Carbon-Containing Materials. Hydrogen's share in the energy market is increasing with the implementation of fuel cell systems and the growing demand for zero-emission fuels. Hydrogen production will need to keep pace with this growing market. In the near term, increased production will likely be met by conventional technologies, such as natural gas reforming. In these processes, the carbon is converted to CO2 and released to the atmosphere. However, with the growing concern about global climate change, alternatives to the atmospheric release of CO2 are being investigated. Sequestration of the CO2 is an option that could provide a viable near-term solution. Reducing the demand on fossil resources remains a significant concern for many nations. Renewable-based processes like solar- or wind-driven electrolysis and photobiological water splitting hold great promise for clean hydrogen production; however, advances must still be made before these technologies can be economically competitive. For the near-and mid-term, generating hydrogen from biomass may be the more practical and viable, renewable and potentially carbon-neutral (or even carbon-negative in conjunction with sequestration) option. Recently, the IEA Hydrogen Agreement launched a new task to bring together international experts to investigate some of these near- and mid-term options for producing hydrogen with reduced environmental impacts. This review of the state of the art of hydrogen production from biomass was prepared to facilitate in the planning of work that should be done to achieve the goal of near-term hydrogen energy systems. The relevant technologies that convert biomass to hydrogen, with emphasis on thermochemical routes are described. In evaluating the viability of the conversion routes, each must be put in the context of the availability of

  7. ARIA: Delivering state-of-the-art InSAR products to end users

    Science.gov (United States)

    Agram, P. S.; Owen, S. E.; Hua, H.; Manipon, G.; Sacco, G. F.; Bue, B. D.; Fielding, E. J.; Yun, S. H.; Simons, M.; Webb, F.; Rosen, P. A.; Lundgren, P.; Liu, Z.

    2016-12-01

    Advanced Rapid Imaging and Analysis (ARIA) Center for Natural Hazards aims to bring state-of-the-art geodetic imaging capabilities to an operational level in support of local, national, and international hazard response communities. ARIA project's first foray into operational generation of InSAR products was with Calimap Project, in collaboration with ASI-CIDOT, using X-band data from the Cosmo-SkyMed constellation. Over the last year, ARIA's processing infrastructure has been significantly upgraded to exploit the free stream of high quality C-band SAR data from ESA's Sentinel-1 mission and related algorithmic improvements to the ISCE software. ARIA's data system can now operationally generate geocoded unwrapped phase and coherence products in GIS-friendly formats from Sentinel-1 TOPS mode data in an automated fashion, and this capability is currently being exercised various study sites across the United States including Hawaii, Central California, Iceland and South America. The ARIA team, building on the experience gained from handling X-band data and C-band data, has also built an automated machine learning-based classifier to label the auto-generated interferograms based on phase unwrapping quality. These high quality "time-series ready" InSAR products generated using state-of-the-art processing algorithms can be accessed by end users using two different mechanisms - 1) a Faceted-search interface that includes browse imagery for quick visualization and 2) an ElasticSearch-based API to enable bulk automated download, post-processing and time-series analysis. In this talk, we will present InSAR results from various global events that ARIA system has responded to. We will also discuss the set of geospatial big data tools including GIS libraries and API tools, that end users will need to familiarize themselves with in order to maximize the utilization of continuous stream of InSAR products from the Sentinel-1 and NISAR missions that the ARIA project will generate.

  8. Tissue engineering: state of the art in oral rehabilitation.

    Science.gov (United States)

    Scheller, E L; Krebsbach, P H; Kohn, D H

    2009-05-01

    More than 85% of the global population requires repair or replacement of a craniofacial structure. These defects range from simple tooth decay to radical oncologic craniofacial resection. Regeneration of oral and craniofacial tissues presents a formidable challenge that requires synthesis of basic science, clinical science and engineering technology. Identification of appropriate scaffolds, cell sources and spatial and temporal signals (the tissue engineering triad) is necessary to optimize development of a single tissue, hybrid organ or interface. Furthermore, combining the understanding of the interactions between molecules of the extracellular matrix and attached cells with an understanding of the gene expression needed to induce differentiation and tissue growth will provide the design basis for translating basic science into rationally developed components of this tissue engineering triad. Dental tissue engineers are interested in regeneration of teeth, oral mucosa, salivary glands, bone and periodontium. Many of these oral structures are hybrid tissues. For example, engineering the periodontium requires growth of alveolar bone, cementum and the periodontal ligament. Recapitulation of biological development of hybrid tissues and interfaces presents a challenge that exceeds that of engineering just a single tissue. Advances made in dental interface engineering will allow these tissues to serve as model systems for engineering other tissues or organs of the body. This review will begin by covering basic tissue engineering principles and strategic design of functional biomaterials. We will then explore the impact of biomaterials design on the status of craniofacial tissue engineering and current challenges and opportunities in dental tissue engineering.

  9. Development of a state-of-the-art solid waste characterisation facility at JRC ISPRA

    International Nuclear Information System (INIS)

    Huhtiniemi, I.; Anselmi, M.; Hubert, P.; Vassallo, G.

    2003-01-01

    This paper will review the development and construction of a state-of-the-art waste characterisation facility that represents a fundamental element in the JRC's strategy to characterise radioactive wastes originating from four decades of nuclear research activities conducted at the Ispra Site. The state-of-the-art NDA measurement solution selected by JRC-Ispra will be presented in the light of special requirements imposed by applicable Italian legislation, norms and the qualities of the waste packages. The intended plant combines the state-of-the-art-measurement solution with comprehensive process automation in an industrial environment and is therefore of significant interest to the radioactive waste management community. (orig.)

  10. MR tomography in myocardial ischaemia: present state of the art

    International Nuclear Information System (INIS)

    Szolar, D.H.; Saeed, M.; Higgins, C.B.

    1996-01-01

    Recent developments in MR imaging have opened up new avenues in the investigation of ischaemic heart disease. Conventional unenhanced spin-echo sequences have been used to detect and quantify myocardial infarction. Along with the technical advances aimed at reducing motion artifacts and imaging time, the advent of contrast media for MR imaging has further strengthened its diagnostic capacities. The applications of MR contrast media are increasing, and they are becoming more specific, to enable differentiation of occlusive and reperfused myocardial infarctions and to discriminate between reversible and irreversible myocardial injury. Previous studies have also indicated that dual administration of both relaxivity-based and susceptibility-based contrast media can be used to determine whether viable myocardium is present in the reperfused ischaemic area. Magnetic susceptibility MR contrast media have the potential to demonstrate a region of the ischaemically injured myocardium in which myocardial necrosis is present. A cornestone in the MR assessment of ischaemic heart disease has been achieved with the advent of fast MR imaging techniques. Ultrafast gradient-recalled-echo sequences or echoplanar imaging allow to monitor the first passage of the contrast medium through the heart. With the aid of MR contrast media, these techniques may be useful in estimating regional myocardial perfusion and blood volume. Experimental and clinical perfusion studies indicate that perfusion-sensitive MR imaging, particularly in concert with coronary vasodilators, can detect compromised myocardium. Combining myocardial perfusion imaging with the anatomic and functional information provided by other MR imaging techniques such as cine and velocity-encoded sequences could make MR imaging a comprehensive noninvasive diagnostic tool for the assessment of ischaemic heart disease. (orig.) [de

  11. Echocardiography in Infective Endocarditis: State of the Art.

    Science.gov (United States)

    Afonso, Luis; Kottam, Anupama; Reddy, Vivek; Penumetcha, Anirudh

    2017-10-25

    In this review, we examine the central role of echocardiography in the diagnosis, prognosis, and management of infective endocarditis (IE). 2D transthoracic echocardiography (TTE) and transesophageal echocardiography TEE have complementary roles and are unequivocally the mainstay of diagnostic imaging in IE. The advent of 3D and multiplanar imaging have greatly enhanced the ability of the imager to evaluate cardiac structure and function. Technologic advances in 3D imaging allow for the reconstruction of realistic anatomic images that in turn have positively impacted IE-related surgical planning and intervention. CT and metabolic imaging appear to be emerging as promising ancillary diagnostic tools that could be deployed in select scenarios to circumvent some of the limitations of echocardiography. Our review summarizes the indispensable and central role of various echocardiographic modalities in the management of infective endocarditis. The complementary role of 2D TTE and TEE are discussed and areas where 3D TEE offers incremental value highlighted. An algorithm summarizing a contemporary approach to the workup of endocarditis is provided and major societal guidelines for timing of surgery are reviewed.

  12. State-of-the-art in control engineering

    Directory of Open Access Journals (Sweden)

    Štefan Kozák

    2014-05-01

    Full Text Available The paper deals with new trends in research, development and applications of advanced control methods and structures based on the principles of optimality, robustness and intelligence. Present trends in the complex process control design demand an increasing degree of integration of numerical mathematics, control engineering methods, new control structures based of distribution, embedded network control structure and new information and communication technologies. Furthermore, increasing problems with interactions, process non-linearities, operating constraints, time delays, uncertainties, and significant dead-times consequently lead to the necessity to develop more sophisticated control strategies. Advanced control methods and new distributed embedded control structures represent the most effective tools for realizing high performance of many technological processes. Main ideas covered in this paper are motivated namely by the development of new advanced control engineering methods (predictive, hybrid predictive, optimal, adaptive, robust, fuzzy logic, and neural network and new possibilities of their SW and HW realizations and successful implementation in industry.

  13. Combining Brain–Computer Interfaces and Assistive Technologies: State-of-the-Art and Challenges

    Science.gov (United States)

    Millán, J. d. R.; Rupp, R.; Müller-Putz, G. R.; Murray-Smith, R.; Giugliemma, C.; Tangermann, M.; Vidaurre, C.; Cincotti, F.; Kübler, A.; Leeb, R.; Neuper, C.; Müller, K.-R.; Mattia, D.

    2010-01-01

    In recent years, new research has brought the field of electroencephalogram (EEG)-based brain–computer interfacing (BCI) out of its infancy and into a phase of relative maturity through many demonstrated prototypes such as brain-controlled wheelchairs, keyboards, and computer games. With this proof-of-concept phase in the past, the time is now ripe to focus on the development of practical BCI technologies that can be brought out of the lab and into real-world applications. In particular, we focus on the prospect of improving the lives of countless disabled individuals through a combination of BCI technology with existing assistive technologies (AT). In pursuit of more practical BCIs for use outside of the lab, in this paper, we identify four application areas where disabled individuals could greatly benefit from advancements in BCI technology, namely, “Communication and Control”, “Motor Substitution”, “Entertainment”, and “Motor Recovery”. We review the current state of the art and possible future developments, while discussing the main research issues in these four areas. In particular, we expect the most progress in the development of technologies such as hybrid BCI architectures, user–machine adaptation algorithms, the exploitation of users’ mental states for BCI reliability and confidence measures, the incorporation of principles in human–computer interaction (HCI) to improve BCI usability, and the development of novel BCI technology including better EEG devices. PMID:20877434

  14. A State-of-the-Art Survey of Indoor Positioning and Navigation Systems and Technologies

    Directory of Open Access Journals (Sweden)

    Wilson Sakpere

    2017-12-01

    Full Text Available The research and use of positioning and navigation technologies outdoors has seen a steady and exponential growth. Based on this success, there have been attempts to implement these technologies indoors, leading to numerous studies. Most of the algorithms, techniques and technologies used have been implemented outdoors. However, how they fare indoors is different altogether. Thus, several technologies have been proposed and implemented to improve positioning and navigation indoors. Among them are Infrared (IR, Ultrasound, Audible Sound, Magnetic, Optical and Vision, Radio Frequency (RF, Visible Light, Pedestrian Dead Reckoning (PDR/Inertial Navigation System (INS and Hybrid. The RF technologies include Bluetooth, Ultra-wideband (UWB, Wireless Sensor Network (WSN, Wireless Local Area Network (WLAN, Radio-Frequency Identification (RFID and Near Field Communication (NFC. In addition, positioning techniques applied in indoor positioning systems include the signal properties and positioning algorithms. The prevalent signal properties are Angle of Arrival (AOA, Time of Arrival (TOA, Time Difference of Arrival (TDOA and Received Signal Strength Indication (RSSI, while the positioning algorithms are Triangulation, Trilateration, Proximity and Scene Analysis/ Fingerprinting. This paper presents a state-of-the-art survey of indoor positioning and navigation systems and technologies, and their use in various scenarios. It analyses distinct positioning technology metrics such as accuracy, complexity, cost, privacy, scalability and usability. This paper has profound implications for future studies of positioning and navigation.

  15. Shrublands and Soil Erosion. An State-of-the-Art

    Science.gov (United States)

    García Estríngana, Pablo; Dunkerley, David; Cerdà, Artemi

    2014-05-01

    Shrublands and Soil Erosion. An State-of-the-Art Arid and semiarid regions occupy two-fifth of the continents (Reynolds et al., 2007). These regions are characterized by dry climatic conditions, recurrent droughts and a scant rainfall pattern with a marked seasonality and a high inter-annual variability which makes water to be a scant resource and vegetation to follow a high variability spatial distribution pattern (Breshears et al., 1998; Cecchi et al., 2006; Dunkerley, 2008). These conditions make these areas more sensitive to climate change (Rowell, 2005) and to land use change as a consequence of land abandonment (Poyatos et al., 2003; Delgado et al., 2010; García-Ruiz, 2010), increasing the risk of desertification (Puigdefábregas and Mendizabal, 1998; Geeson et al., 2002), in such a way that 65-70% of arid and semiarid areas are vulnerable to this degradation process (UNEP, 1991). Soil Erosion and Land Degradation are closely related to the changes in the vegetation cover (Zhao et al., 2013). Although other factors such as rainfall intensity or slope (Ziadat and Taimeh, 2013) the plant cover is the main factor that controls the soil erosion, controlling the infiltration and runoff generation (Cerdà, 1998a; Kargar Chigani et al., 2012; Haregeweyn, 2013). Soil erosion show non-sustainable rates under these regions, such as under Mediterranean conditions (Cerdà et al., 2010) and on agriculture land (Cerdà et al; 2007; 2009) due to climatic conditions, to parent material and to the roughed terrain (Romero Díaz et al., 2010). The traditional impact of grazing, of extremely intense fires, of ploughing and the widespread use of herbicides on agriculture, the increase of the road and railway embankments and the agricultural land abandonment cause vegetation removal. Canopy cover partitions rainfall reducing the amount of water reaching the soil and the kinetic energy of rainfall drops, protecting the soil against the impact of rainfall drops. Vegetation

  16. State of the art and trends for digital pathology.

    Science.gov (United States)

    García Rojo, Marcial

    2012-01-01

    Anatomic pathology is a medical specialty where both information management systems and digital images systems paly a most important role. Digital pathology is a new concept that considers all uses of this information, including diagnosis, biomedical research and education. Virtual microscopy or whole slide imaging, resulting in digital slides, is an outreaching technology in anatomic pathology. Limiting factors in the expansion of virtual microscopy are formidable storage dimension, scanning speed, quality of image and cultural change. Anatomic pathology data and images should be an important part of the patient electronic health records as well as of clinical data warehouse, epidemiological or biomedical research databases, and platforms dedicated to translational medicine. Integrating anatomic pathology to the "healthcare enterprise" can only be achieved using existing and emerging medical informatics standards like Digital Imaging and Communications in Medicine (DICOM®1), Health Level Seven (HL7®), and Systematized Nomenclature of Medicine-Clinical Terms (SNOMED CT®), following the recommendations of Integrating the Healthcare Enterprise (IHE®). The consequences of the full digitalization of pathology departments are hard to foresee, but short term issues have arisen that imply interesting challenges for health care standards bodies.

  17. Analysis and simulation of emergency departments: state of the art and prospects

    OpenAIRE

    Vanbrabant, Lien; Braekers, Kris; Ramaekers, Katrien

    2017-01-01

    This abstract gives a brief overview of the state of the art on the analysis and simulation of emergency departments in hospitals. Based on this, research opportunities which will be addressed during my PhD are identified.

  18. Assessment of the State of the Art of Flight Control Technologies as Applicable to Adverse Conditions

    Science.gov (United States)

    Reveley, Mary s.; Briggs, Jeffrey L.; Leone, Karen M.; Kurtoglu, Tolga; Withrow, Colleen A.

    2010-01-01

    Literature from academia, industry, and other Government agencies was surveyed to assess the state of the art in current Integrated Resilient Aircraft Control (IRAC) aircraft technologies. Over 100 papers from 25 conferences from the time period 2004 to 2009 were reviewed. An assessment of the general state of the art in adaptive flight control is summarized first, followed by an assessment of the state of the art as applicable to 13 identified adverse conditions. Specific areas addressed in the general assessment include flight control when compensating for damage or reduced performance, retrofit software upgrades to flight controllers, flight control through engine response, and finally test and validation of new adaptive controllers. The state-of-the-art assessment applicable to the adverse conditions include technologies not specifically related to flight control, but may serve as inputs to a future flight control algorithm. This study illustrates existing gaps and opportunities for additional research by the NASA IRAC Project

  19. Nanoimaging in cardiovascular diseases: Current state of the art

    Directory of Open Access Journals (Sweden)

    Suryyani Deb

    2015-01-01

    Full Text Available Nanotechnology has been integrated into healthcare system in terms of diagnosis as well as therapy. The massive impact of imaging nanotechnology has a deeper intervention in cardiology i.e. as contrast agents , to target vulnerable plaques with site specificity and in a theranostic approach to treat these plaques, stem cell delivery in necrotic myocardium, etc. Thus cardiovascular nanoimaging is not limited to simple diagnosis but also can help real time tracking during therapy as well as surgery. The present review provides a comprehensive description of the molecular imaging techniques for cardiovascular diseases with the help of nanotechnology and the potential clinical implications of nanotechnology for future applications.

  20. Symposium Connects Government Problems with State of the Art Network Science Research

    Science.gov (United States)

    2015-10-16

    Symposium Connects Government Problems with State-of-the- Art Network Science Research By Rajmonda S. Caceres and Benjamin A. Miller Network...the US Gov- ernment, and match these with the state-of-the- art models and techniques developed in the network science research community. Since its... science has grown significantly in the last several years as a field at the intersec- tion of mathematics, computer science , social science , and engineering

  1. State-of-the-art computer technologies used to train nuclear specialists and to conduct research

    International Nuclear Information System (INIS)

    Korovin, Yu.A.; Tikhonenko, A.V.

    2011-01-01

    The paper discusses innovative methods used in the process of training nuclear specialists and conducting research which are based on state-of-the-art computer technologies. The approach proposed makes wide use of mathematical modeling and state-of-the-art programming techniques. It is based on the development, improvement and application of problem-oriented computer codes to support the teaching process and to solve fundamental and applied problems of nuclear physics and nuclear engineering.

  2. A quick guide to wind power forecating : state-of-the-art 2009.

    Energy Technology Data Exchange (ETDEWEB)

    Monteiro, C.; Keko, H.; Bessa, R.; Miranda, V.; Botterud, A.; Wang, J.; Conzelmann, G.; Decision and Information Sciences; INESC Porto

    2009-11-20

    This document contains a summary of the main findings from our full report entitled 'Wind Power Forecasting: State-of-the-Art 2009'. The aims of this document are to provide guidelines and a quick overview of the current state-of-the-art in wind power forecasting (WPF) and to point out lines of research in the future development of forecasting systems.

  3. Battery systems. State of the art; Batteriesysteme. Stand der Technik

    Energy Technology Data Exchange (ETDEWEB)

    Jossen, Andreas; Doering, Harry [Zentrum fuer Sonnenenergie- und Wasserstoff-Forschung, Ulm (Germany)

    2009-07-01

    Due to the emergence of electromobility and the increase in the fluctuating supply of renewable energy (wind and PV) electrical storage systems are gaining in importance again. In the area of electromobility they have even become a key technology. In the electromobile sector a clear decision in favour of Li ion batteries has already been evident for some time. None of the other technologies are being discussed any longer with regard to this application. Hybrid vehicles today mostly use NiMH storages, but this area too will see the entry of Li ion batteries. In the microhybrid area the improvements achieved with lead batteries will play an important role. Regarding stationary systems there is as yet no such clear-cut focus on any single technology to be observed, but rather a number of technologies being developed and tested concurrently. Redox flow batteries and high temperature batteries will play an important role here. However, lithium ion systems will try to get a foot in the door in this area as well.

  4. MR angiography in portal hypertension: state of the art

    International Nuclear Information System (INIS)

    Vosshenrich, R.; Fischer, U.; Grabbe, E.

    2001-01-01

    When imaging the portal vascular system colour-coded sonography and CT angiography are used as an alternative to intraarterial DSA. Today fast CE 3D- MRA is the imaging modality of choice in the diagnostic of patients with portal hypertension. It enables a clear picture of the portalvenous vascular system and portalsystemic shunts. Statements regarding velocity and direction of blood flow can be made with additional use of TOF and PC techniques. CE-3D MRA can be used preoperatively before liver transplantation or shunt surgery. In the follow-up of interventional or surgical procedures exact statements concerning haemodynamically significant pathologies e.g. vascular thromboses, stenoses and occlusions can be made. Patient consent is symplify and the numbers of complications can be reduced as well as duration of surgery minimized applying this technique (orig.) [de

  5. Functional MRI: Genesis, State of the art and the Sequel

    International Nuclear Information System (INIS)

    Bharath, Rose Dawn

    2014-01-01

    The last 25 years have seen functional magnetic resonance imaging (fMRI) grow from an interesting experimental imaging technique in the hands of some to a primary investigation of choice in the localization and lateralization of brain function prior to surgery. Developments in the field of computational neurosciences have transformed fMRI analysis from classical subtractive type analysis to dynamic casual modeling, and now to graph theory analysis. This has widened the scope of fMRI, and is therefore finding applications in understanding neural correlates of diseases like autism and Alzheimer's disease, prognostication of diseases like traumatic brain injury, and has the potential to direct therapy. It is unfortunately true that this widened ambit has not received the clinical attention it deserves, probably because fMRI is susceptible to artifacts from skull base and blood products and has reduced sensitivity in patients with vascular malformations, or because a change in medical practice usually lags behind the technological and scientific developments that make it possible. This review focuses on the developmental chronology of fMRI image analysis in the last 25 years with highlights on major milestones like developments in the field of paradigms, analysis methods, resting state fMRI, and functional connectivity. To make the statistical images of brain at work more colorful, the article starts with genesis of fMRI and ends with the hope of a promising bright future. Many inputs for this article are obtained from a series of 103 review articles edited by Bandettini et al., compiling personal experiences of pioneers in this field. Interested readers are encouraged to refer to these for a more complete overview.

  6. Audiodescription Research: State of the Art and Beyond

    OpenAIRE

    Braun, S

    2008-01-01

    Audiodescription (AD) is a growing arts and media access service for visually impaired people. As a practice rooted in intermodal mediation, i.e. ’translating’ visual images into verbal descriptions, it is in urgent need of interdisciplinary research-led grounding. Seeking to stimulate further research in this field, this paper aims to discuss the major dimensions of AD, give an overview of completed an ongoing research relating to each of these dimensions and outline questions for further ac...

  7. Wall thickness measurements using digital radiography - state of the art

    International Nuclear Information System (INIS)

    Wawrzinek, T.; Zscherpel, U.; Bellon, C.

    1997-01-01

    Projection radiography is a method long since used for wall thickness measurements in pipes. Another method sometimes applied is thickness determination based on measuring changes of the optical density by using radioactive isotopes, as in this case the effects of stray radiation are negligible. The two methods hitherto were to be performed manually, and wall thickness data were derived by calculations with a pocket calculator. The required measuring and calculating work can now be automated by way of computerized processing of digitised images. The paper presents the software for automated evaluation of data of a selected location after system calibration. (orig./CB) [de

  8. State-of-the-art Space Telescope Digicon performance data

    Science.gov (United States)

    Ginaven, R. O.; Choisser, J. P.; Acton, L.; Wysoczanski, W.; Alting-Mees, H. R.; Smith, R. D., II; Beaver, E. A.; Eck, H. J.; Delamere, A.; Shannon, J. L.

    1980-01-01

    The Digicon has been chosen as the detector for the High Resolution Spectrograph and the Faint Object Spectrograph of the Space Telescope. Both tubes are 512 channel, parallel-output devices and feature CsTe photocathodes on MgF2 faceplates. Using a computer-assisted test facility, the tubes have been characterized with respect to diode array performance, photocathode response (1100-9000 A), and imaging capability. Data are presented on diode dark current and capacitance distributions, pulse height resolution, photocathode quantum efficiency, uniformity and blemishes, dark count rate, distortion, resolution, and crosstalk.

  9. PEOPLE RETRIEVAL BY MEANS OF COMPOSITE PICTURES: PROBLEM STATE-OF-THE-ART AND TECHNOLOGIES

    Directory of Open Access Journals (Sweden)

    Georgy A. Kukharev

    2014-11-01

    Full Text Available We discuss the problem of people retrieval by means of composite pictures constructed according to descriptive portrait. An overview of the problem state-of-the-art is provided beginning from the basic concepts and terminology to a modern technology for composite picture creation, real-world scenarios and search results. The development history of systems for forming composite portraits (photo robots and sketches and the ideas implemented in these systems are provided. The problem of automatic comparison of composite pictures with the original ones is discussed, and the reasons for unattainability of stable retrieval of originals by a composite picture in real-world scenarios are revealed. Requirements to composite pictures databases in addition to the existing benchmark databases of facial images and also methods for implementation of such databases are formulated. Approaches for generation of sketches population from an initial one that increase effectiveness of identikit-based photo image retrieval systems are proposed. The method of similarity index increasing in the couple identikit-photograph based on computation of an average identikit from the created population is provided. It is shown that such composite pictures are more similar to original portraits and their use in the discussed search problem can lead to good results. Thus the created identikits meet the requirements of the truthful scenario as take into account the possibility of incomplete information in descriptions. Results of experiments on CUHK Face Sketch and CUHK Face Sketch FERET databases and also open access identikits and corresponding photos are discussed.

  10. Exploring the Central Nervous System: methodological state of the art

    International Nuclear Information System (INIS)

    Darcourt, Jacques; Koulibaly, Pierre-Malick; Migneco, Octave

    2005-01-01

    The analysis of the clinical use of brain SPECT demonstrate a defacing between the methodological developments published recently and its current use in clinical practice. We review a description of recent methodological developments that could be useful in three classical clinical application: the diagnosis of Alzheimer's disease, the evaluation of dopaminergic neurotransmission in Parkinson's Disease and the study of epilepsy. In Alzheimer's disease the methods of spatial standardization and the comparison to a normative data base are more useful to observers that have the least experience and for this end methodological approaches that are oriented to routine work better and are simpler than SPM. Quantification is essential in the study of dopaminergic neurotransmission and the measurement of binding potential appears biased due to septal penetration, attenuation, diffusion and partial volume effect. Partial volume effect introduces most error and its correction is difficult because of the co registration precision required with magnetic resonance images. The study of epilepsy by subtraction of ictal and interictal SPECT has demonstrated its clinical value. It is a fusion of images operation that has now very well defined methods (au)

  11. Positron Emission Tomography: state of the art and future developments

    International Nuclear Information System (INIS)

    Pizzichemi, M.

    2016-01-01

    Positron emission tomography (PET) plays a fundamental role in medical imaging, with a wide range of applications covering, among the others, oncology, neurology and cardiology. PET has undergone a steady technological evolution since its introduction in mid 20th century, from the development of 3D PET in the late 1980s, to the invention of PET/CT in the 1990s and more recently with the introduction of PET/MR scanners. The current research topics aiming to develop the next generation of PET scanners are summarized in this paper, focusing on the efforts to increase the sensitivity of the detectors, as long as improving their timing, spatial and energy resolutions, with the final goal of reducing the amount of radioactive dose received by the patients and the duration of the exams while improving at the same time the detectability of lesions.

  12. Brain radioligands. State of the art and new trends

    International Nuclear Information System (INIS)

    Halldin, C.; Gulyas, B.; Langer, O.; Farde, L.

    2001-01-01

    Non-invasive radioligand imaging methods for brain receptor studies use either short-lived positron-emitting radionuclides such as 11 C and 18 F for positron emission tomography (PET) or single photon-emitting radionuclides such as 123 I for single photon emission computed tomography (SPECT). PET and SPECT use radioligands which are injected intravenously into experimental animals, human volunteers or patients. The main applications of radioligands in brain research concern human neuro psychopharmacology and the discovery and development of novel drugs to be used in the therapy of neurological and psychiatric disorders. A basic problem in PET and SPECT brain receptor studies is the lack of useful radioligands with appropriate binding characteristics. Prerequisite criteria need to be satisfied for a radioligand to reveal target binding sites in vivo. This section will discuss these important criteria and also review recent examples in neuro receptor radioligand development such as selective radioligands for brain monoamine transporters

  13. Clinical cardiac positron emission tomography: State of the art

    International Nuclear Information System (INIS)

    Gould, K.L.

    1991-01-01

    Cardiac positron emission tomography (PET) has evolved rapidly from a relatively esoteric research tool into clinical applications providing unique, quantitative information on myocardial perfusion, metabolism, and cell membrane function and having a potentially significant impact on cardiovascular medicine. Although there are many different positron radionuclides for imaging diverse myocardial behavior, three radionuclides have reached accepted clinical utility. Cardiac PET using nitrogen-13-ammonia, rubidium-82, and fluoro-18-deoxyglucose has proved accurate and definitive in multiple university and private-practice sites for diagnosing and assessing severity and location of coronary artery disease in symptomatic or asymptomatic patients, for identifying injured but viable myocardium potentially salvageable by revascularization, and for ruling out clinically significant coronary artery stenosis with a high specificity in patients who might otherwise undergo coronary arteriography to document the absence of significant disease. 89 references

  14. Intensity-modulated radiotherapy -the State of the Art

    International Nuclear Information System (INIS)

    Ling, C.

    2002-01-01

    Full text: In the last two decades of the last century, the development of three-dimensional conformal radiotherapy (3D-CRT) has substantially reduces the volume of critical organs irradiated to high doses, and has permitted the increase of tumor dose without concomitant increase in normal tissue complication. At Memorial Sloan Kettering Cancer Center, a clinical trial in cancer of the prostate has accrued >1600 patient and the prescription dose has been escalated to 81 Gy with 3D-CRT, and to 86.4 Gy using intensity modulated radiotherapy (IMRT), with promising results. 3D-CRT and IMRT involves the delineation of target and non-target structures from patient-specific 3D image data-sets (primarily CT, sometimes supplemented with MRI, PET etc.), the calculation and display of 3D dose distributions, the analysis and evaluation of structure-specific dose-volume data (DVH-dose volume histogram), radiation delivery with computer-controlled multileaf collimators (MLC), and treatment verification with electronic portal images. However, the dose distribution conformality achieved with 3D-CRT can be further improved by the use of computer-optimized IMRT. In addition, the treatment design phase of 3D-CRT involves several iterative steps and can be time-consuming, particularly when the anatomical geometry is complex. Thus, IMRT is an incremental advance from 3D-CRT with two key enhancements: 1) computerized iterative treatment plan optimization, and 2) the use of intensity-modulated radiation beams. To deliver the IM beams, one efficacious approach is to use MLC in the dynamic mode, using the so-called sliding-window technique, i.e. the leaves of the MLC are in motion while the radiation is being delivered. Since 1995, we have treated over 1500 patients with IMRT. This discussion shall describe the physical aspects of IMRT, emphasizing those features and benefits unique to this approach. Pertinent clinical results will also be briefly presented

  15. HyPer Family Probes: State of the Art.

    Science.gov (United States)

    Bilan, Dmitry S; Belousov, Vsevolod V

    2016-05-01

    Hydrogen peroxide (H2O2) is not only a key mediator of oxidative stress but also one of the most important cellular second messengers. This small short-lived molecule is involved in the regulation of a wide range of different biological processes, including regulation of cellular signaling pathways. Studying the role of H2O2 in living systems would be challenging without modern approaches. A genetically encoded fluorescent biosensor, HyPer, is one of the most effective tools for this purpose. HyPer has been used by many investigators of redox signaling in various models of different scales: from cytoplasmic subcompartments and single cells to tissues of whole organisms. In many studies, the results obtained using HyPer have enabled a better understanding of the roles of H2O2 in these biological processes. However, much remains to be learned. In this review, we focus on the uses of HyPer. We provide a general description of HyPer and its improved versions. Separate chapters are devoted to the results obtained by various groups who have used this biosensor for their experiments in living cells and organisms. HyPer is an effective tool for H2O2 imaging in living systems as indicated by the increasing numbers of publications each year since its development. However, this biosensor requires further improvements. In particular, much brighter and more pH-stable versions of HyPer are necessary for imaging in mammalian tissues. Antioxid. Redox Signal. 24, 731-751.

  16. The state-of-the-art in 3D orebody modelling: a case study of KDC East gold mine, South Africa

    CSIR Research Space (South Africa)

    Manzi, MS

    2013-10-01

    Full Text Available The state-of-the-art in 3D modelling of the structurally complex orebody begins with (1) 3D seismic imaging, (2) horizon picking, (3) data conditioning, (4) fault detection, (5) fault-horizon projection, (6) data integration, and (7) statistical...

  17. [Kleine-Levin syndrome: state of the art].

    Science.gov (United States)

    Arnulf, I; Lecendreux, M; Franco, P; Dauvilliers, Y

    2008-01-01

    Kleine-Levin syndrome is a rare neurological disorder (1-2 cases per million inhabitants) primarily affecting young subjects. It is characterized by relapsing-remitting episodes of hypersomnia in association with cognitive and behavioral disturbances. Case-reports, small series, meta-analysis and a recent large, prospective trio study are consistent with a homogeneous, genuine disease entity. Patients are mostly male (68-78%) and adolescents (81%), with mean onset at 15 years (range 4-82 years). The first episode is triggered by an infection in 72% of patients. Patients experience an average of 7-19 episodes of 10-13 days each, relapsing every 3.5 months. Episodes recur more quickly in patients with childhood onset. The median disease course is 8-14 years, with longer course in men, in patients with hypersexuality, and when onset is after age 20. During episodes, all patients have hypersomnia (with sleep lasting 15-21 heures per day), cognitive impairment (apathy, confusion, slowness, amnesia) and a specific feeling of derealization (dreamy state, altered perception). Less frequently, patients experience hyperphagia (66%), hypersexuality (53%, principally men) and depressed mood (53%, predominantly women). Patients are remarkably similar to controls between episodes regarding sleep, vigilance, mood, and eating attitude, but have increased body mass index. Structural brain imaging, evaluation of the cerebrospinal fluid and serological inflammatory markers are unremarkable. EEG slowing is notable in 70% of cases during episodes, without epileptic activity. Sleep structure varies from harmonious hypersomnia to hypo-arousal with low sleep efficiency. The brain scintigraphy may show hypoperfusion, mostly focused on the thalamic, hypothalamic and fronto-temporal areas, especially when contrasted to images obtained between episodes. Newly identified factors include increased birth and developmental problems, Jewish heritage, genetics (5% multiplex families, suggesting

  18. MRI for solitary pulmonary nodule and mass assessment: Current state of the art.

    Science.gov (United States)

    Ohno, Yoshiharu; Kauczor, Hans-Ulrich; Hatabu, Hiroto; Seo, Joon Beom; van Beek, Edwin J R

    2018-03-23

    Since the clinical introduction of magnetic resonance imaging (MRI), the chest has been one of its most challenging applications, and many physicists and radiologists have tried since the 1980s to use MR for assessment of different lung diseases as well as mediastinal and pleural diseases. Since then, however, technical advances in sequencing, scanners, and coils, adaptation of parallel imaging techniques, utilization of contrast media, and development of postprocessing tools have been reported by many basic and clinical researchers. As a result, state-of-the-art thoracic MRI is now substituted for traditional imaging techniques and/or plays a complementary role in the management of patients with various chest diseases, and especially in the detection of pulmonary nodules and in thoracic oncology. In addition, MRI has continued to be developed to help overcome the limitations of computed tomography (CT) and nuclear medicine examinations. It can currently provide not only morphological, but also functional, physiological, pathophysiological, and molecular information at 1.5T with a gradual shift from 1.5T to 3T MR systems. In this review, we focus on these recent advances in MRI for pulmonary nodule detection and pulmonary nodule and mass evaluation by using noncontrast-enhanced and contrast-enhanced techniques as well as new molecular imaging methods such as chemical exchange saturation transfer imaging for a comparison with other modalities such as single or multidetector row CT, 18F-fluoro-2-deoxyglucose positron emission tomography (FDG-PET), and/or PET/CT. 4 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2018. © 2018 International Society for Magnetic Resonance in Medicine.

  19. Myofibrillar myopathies: State of the art, present and future challenges.

    Science.gov (United States)

    Béhin, A; Salort-Campana, E; Wahbi, K; Richard, P; Carlier, R-Y; Carlier, P; Laforêt, P; Stojkovic, T; Maisonobe, T; Verschueren, A; Franques, J; Attarian, S; Maues de Paula, A; Figarella-Branger, D; Bécane, H-M; Nelson, I; Duboc, D; Bonne, G; Vicart, P; Udd, B; Romero, N; Pouget, J; Eymard, B

    2015-10-01

    Myofibrillar myopathies (MFM) have been described in the mid-1990s as a group of diseases sharing common histological features, including an abnormal accumulation of intrasarcoplasmic proteins, the presence of vacuoles and a disorganization of the intermyofibrillar network beginning at the Z-disk. The boundaries of this concept are still uncertain, and whereas six genes (DES, CRYAB, LDB3/ZASP, MYOT, FLNC and BAG3) are now classically considered as responsible for MFM, other entities such as FHL1 myopathy or Hereditary Myopathy with Early Respiratory Failure linked to mutations of titin can now as well be included in this group. The diagnosis of MFM is not always easy; as histological lesions can be focal, and muscle biopsy may be disappointing; this has led to a growing importance of muscle imaging, and the selectivity of muscle involvement has now been described in several disorders. Due to the rarity of these myopathies, if some clinical patterns (such as distal myopathy associated with cardiomyopathy due to desmin mutations) are now well known, surprises remain possible and should lead to systematic testing of the known genes in case of a typical histological presentation. In this paper, we aim at reviewing the data acquired on the six main genes listed above as well as presenting the experience from two French reference centres, Paris and Marseilles. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

  20. State of the art: stem cells in equine regenerative medicine.

    Science.gov (United States)

    Lopez, M J; Jarazo, J

    2015-03-01

    According to Greek mythology, Prometheus' liver grew back nightly after it was removed each day by an eagle as punishment for giving mankind fire. Hence, contrary to popular belief, the concept of tissue and organ regeneration is not new. In the early 20th century, cell culture and ex vivo organ preservation studies by Alexis Carrel, some with famed aviator Charles Lindbergh, established a foundation for much of modern regenerative medicine. While early beliefs and discoveries foreshadowed significant accomplishments in regenerative medicine, advances in knowledge within numerous scientific disciplines, as well as nano- and micromolecular level imaging and detection technologies, have contributed to explosive advances over the last 20 years. Virtually limitless preparations, combinations and applications of the 3 major components of regenerative medicine, namely cells, biomaterials and bioactive molecules, have created a new paradigm of future therapeutic options for most species. It is increasingly clear, however, that despite significant parallels among and within species, there is no 'one-size-fits-all' regenerative therapy. Likewise, a panacea has yet to be discovered that completely reverses the consequences of time, trauma and disease. Nonetheless, there is no question that the promise and potential of regenerative medicine have forever altered medical practices. The horse is a relative newcomer to regenerative medicine applications, yet there is already a large body of work to incorporate novel regenerative therapies into standard care. This review focuses on the current state and potential future of stem cells in equine regenerative medicine. © 2014 EVJ Ltd.

  1. [Principles of Teaching in Surgery - State of the Art].

    Science.gov (United States)

    Busemann, A; Patrzyk, M; Busemann, C; Heidecke, C-D

    2016-06-01

    Ten to 15 years ago the number of applications for a surgical residency position was very much larger than the positions available. Today, this situation has clearly reversed itself as indicated through a noticeable deficit in recruits. The decision to become a surgeon has become more uncommon. This can be blamed upon not only the demotivatingly viewed "work-life imbalance" associated with being a surgeon, but also on the basically non-inspiring training process during medical school. Due to the fact that university educators/instructors are not fundamentally trained teachers, they often fail in their capacity to convey their extensive knowledge to medical students and potentially future surgical residents. The quality of primary as well as postgraduate training is an important central factor in the effort to once again restore the attractive image of surgery within the realm of the medical disciplines. This paper presents an overview of the basic modern training concepts by which every surgeon should be able to effectively convey knowledge and practical skills. Furthermore, this work should inspire a more intensive interest in clinical graduate and postgraduate education. Due to the hand in hand relationship, this manuscript does not differentiate between student teaching and postgraduate training. Georg Thieme Verlag KG Stuttgart · New York.

  2. State-of-the-art of dentistry radiological services

    International Nuclear Information System (INIS)

    Yacovenco, Alejandro; Tauhata, Luiz; Infantosi, Antonio F.C.

    2001-01-01

    There are estimated that the dental X-ray participates today with about 20% of the total number of radiological exams accomplished at the country. According to data of the National Commission of Nuclear Energy (CNEN) more than 80% of the radiological exams are accomplished internationally with superior doses to the limits accepted. That picture, ally to an inefficient acting of X-ray apparels and the obtaining of radiological images of low diagnose quality did not suffer alterations for more than 20 years, in spite of a series of initiatives and attempts of the part of CNEN. Before this problematic one the work of implementation of the Quality Assurance System it was in evidence for the reached results. In an unpublished work, counting with the participation of the private initiative, begun with an understanding work and the surgeon's dentist's motivation, to give support for the procedures be it accomplished and basing on the control of the equipment and in the measure of the radiations in correct metrological way, it was gotten to modify the distribution of the dose absorbed in the entrance of the skin. As more important results stand out the improvement in the processing of the film in more than 46% of the dental clinics, reduction of the time of exhibition in more than 70% of the apparels of X-rays and a reduction of the dose of the order of 76%. (author)

  3. [Robotic assistance in gynaecological surgery: State-of-the-art].

    Science.gov (United States)

    Monsarrat, N; Collinet, P; Narducci, F; Leblanc, E; Vinatier, D

    2009-05-01

    From the Automated Endoscopic System for Optimal Positioning (AESOP), a robotic arm which operates the laparoscope, to the robots Zeus and da Vinci, robotic assistance in gynaecological endoscopic surgery has continuously evolved for the last fifteen years or so. It has brought about new technical advancements: the last generation robots offer a steady three-dimensional image, improved instrument dexterity and precision, higher ergonomics and comfort for the surgeon. The da Vinci robotic system has been used without evincing any specific morbidity in various cases, notably for tubal reanastomosis, myomectomy, hysterectomy, pelvic and para-aortic lymphadenectomy or sacrocolpopexy amongst others. Robotic assistance in gynaecology is thus feasible. Like conventional laparoscopic surgery, it allows decreased blood loss and morbidity as well as shorter hospital stay, as compared to laparotomy. It might indeed allow many surgical teams to perform minimally invasive surgical procedures which they were not used to performing by laparoscopy. Randomized prospective studies are needed to define its indications more precisely. Besides, its medico-financial impact should be evaluated too.

  4. Thermosensitive liposomal drug delivery systems: state of the art review

    Directory of Open Access Journals (Sweden)

    Kneidl B

    2014-09-01

    Full Text Available Barbara Kneidl,1,2 Michael Peller,3 Gerhard Winter,2 Lars H Lindner,1 Martin Hossann11Department of Internal Medicine III, University Hospital Munich, 2Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, 3Institute for Clinical Radiology, University Hospital Munich, Ludwig-Maximilians University, Munich, GermanyAbstract: Thermosensitive liposomes are a promising tool for external targeting of drugs to solid tumors when used in combination with local hyperthermia or high intensity focused ultrasound. In vivo results have demonstrated strong evidence that external targeting is superior over passive targeting achieved by highly stable long-circulating drug formulations like PEGylated liposomal doxorubicin. Up to March 2014, the Web of Science listed 371 original papers in this field, with 45 in 2013 alone. Several formulations have been developed since 1978, with lysolipid-containing, low temperature-sensitive liposomes currently under clinical investigation. This review summarizes the historical development and effects of particular phospholipids and surfactants on the biophysical properties and in vivo efficacy of thermosensitive liposome formulations. Further, treatment strategies for solid tumors are discussed. Here we focus on temperature-triggered intravascular and interstitial drug release. Drug delivery guided by magnetic resonance imaging further adds the possibility of performing online monitoring of a heating focus to calculate locally released drug concentrations and to externally control drug release by steering the heating volume and power. The combination of external targeting with thermosensitive liposomes and magnetic resonance-guided drug delivery will be the unique characteristic of this nanotechnology approach in medicine.Keywords: thermosensitive liposomes, phosphatidyloligoglycerol, hyperthermia, high intensity focused ultrasound, drug delivery, drug targeting

  5. Current State-of-the-Art MRI for Comprehensive Evaluation of Potential Living Liver Donors.

    Science.gov (United States)

    Jhaveri, Kartik S; Guo, Lijun; Guimarães, Luís

    2017-07-01

    This review focuses on the role of state-of-the-art MRI-based techniques for comprehensive evaluation of living donors providing single-visit assessment of the liver vasculature via MR angiography, of the biliary tract via conventional T2-weighted MR cholangiography and T1-weighted gadoxetate disodium-enhanced MR cholangiography, and of hepatic steatosis via T2*-corrected multiecho chemical shift-based water-fat separation MRI and high-speed T2-corrected multiecho MR spectroscopy. By using current state-of-the-art techniques, MRI can provide a one-stop-shop method for evaluation of the potential living liver donors.

  6. State-of-the-art multi-wavelength observations of nearby brightest group/cluster galaxies

    Science.gov (United States)

    Gendron-Marsolais, Marie-Lou; Hlavacek-Larrondo, Julie

    2018-01-01

    Nearby galaxy groups and clusters are crucial to our understanding of the impact of nuclear outbursts on the intracluster medium as their proximity allows us to study in detail the processes of feedback from active galactic nuclei in these systems. In this talk, I will present state-of-the-art multi-wavelength observations signatures of this mechanism.I will first show results on multi-configuration 230-470 MHz observations of the Perseus cluster from the Karl G. Jansky Very Large Array, probing the non-thermal emission from the old particle population of the AGN outflows. These observations reveal a multitude of new structures associated with the “mini-halo” and illustrate the high-quality images that can be obtained with the new JVLA at low radio-frequencies.Second, I will present new observations with the optical imaging Fourier transform spectrometer SITELLE (CFHT) of NGC 1275, the Perseus cluster's brightest galaxy. With its wide field of view, it is the only integral field unit spectroscopy instrument able to cover the large emission-line filamentary nebula in NGC 1275. I will present the first detailed velocity map of this nebula in its entirety and tackle the question of its origin (residual cooling flow or dragged gas).Finally, I will present deep Chandra observations of the nearby early-type massive elliptical galaxy NGC 4472, the most optically luminous galaxy in the local Universe, lying on the outskirts of the Virgo cluster. Enhanced X-ray rims around the radio lobes are detected and interpreted as gas uplifted from the core by the buoyant rise of the radio bubbles. We estimate the energy required to lift the gas to constitute a significant fraction of the total outburst energy.I will thus show how these high-fidelity observations of nearby brightest group/cluster galaxies are improving our understanding of the AGN feedback mechanism taking place in galaxy groups and clusters.

  7. Measuring the State-of-the-Art in Laser Cut Quality

    OpenAIRE

    Pocorni, Jetro; Powell, John; Ilar, Torbjörn; Schwarz, A.; Kaplan, Alexander

    2013-01-01

    This paper discusses the strategy appropriate to investigating the state of the art of laser cutting from an industrial point of view. The importance of creating the samples in a high quality industrial environment is emphasised and preliminary results are presented.

  8. Performance Measurement in Belgian Hospitals : a state-of-the-art

    OpenAIRE

    Van Caillie, Didier; Rouhana, Rima; Santin, Sarah

    2007-01-01

    This communication proposes a global state-of-the-art around the central question : "How is performance measured and controlled in Belgian hospitals. As a first step in a global research project dedicated to the use of Balanced ScoreCard in publics hospitals around the world, it is essentially focused on global economic aspects and on major macroeconomic statistics.

  9. Laser Beam Machining (LBM), State of the Art and New Opportunities

    NARCIS (Netherlands)

    Meijer, J.

    2004-01-01

    An overview is given of the state of the art of laser beam machining in general with special emphasis on applications of short and ultrashort lasers. In laser welding the trend is to apply optical sensors for process control. Laser surface treatment is mostly used to apply corrosion and wear

  10. The emancipatory character of action research, its history and the present state of the art

    NARCIS (Netherlands)

    Boog, B.

    2003-01-01

    Right from the start. action research was intended to be emancipatory research, and it still is. This article will underpin this by outlining its history and the present state of the art. Though a variety of action research approaches have developed along divergent theoretical pathways, it will be

  11. State of the art in power cable design, failure mechanisms and testing

    International Nuclear Information System (INIS)

    Orton, H.

    2005-01-01

    This presentation describes state of the art in power cable design, failure mechanisms and testing. It gives a history of cable usage and design of cables, describes different cable types, assessment of the condition of cables, aging and failures, testing and diagnostics

  12. State of the Art on Alternative Fuels in Aviation. Executive summary

    NARCIS (Netherlands)

    Blakey, S.; Novelli, P.; Costes, P.; Bringtown, S.; Christensen, D.; Sakintuna, B.; Peineke, C.; Jongschaap, R.E.E.; Conijn, J.G.; Rutgers, B.; Valot, L.; Joubert, E.; Perelgritz, J.F.; Filogonio, A.; Roetger, T.; Prieur, A.; Starck, L.; Jeuland, N.; Bogers, P.; Midgley, R.; Bauldreay, J.; Rollin, G.; Rye, L.; Wilson, C.

    2010-01-01

    This paper summarises the findings from the SWAFEA preliminary state of the art study. It covers trends in aspects of future air transport, potential candidate fuels and associated feedstock along with sustainability and economical issues relevant for alternative fuels in aviation..

  13. Conservation physiology of marine fishes: state of the art and prospects for policy

    NARCIS (Netherlands)

    Mckenzie, David J.; Axelsson, Michael; Chabot, Denis; Claireaux, Guy; Cooke, Steven J.; Corner, Richard A.; Boeck, De Gudrun; Domenici, Paolo; Guerreiro, Pedro M.; Hamer, Bojan; Jørgensen, Christian; Killen, Shaun S.; Lefevre, Sjannie; Marras, Stefano; Michaelidis, Basile; Nilsson, Göran E.; Peck, Myron A.; Perez-Ruzafa, Angel; Rijnsdorp, Adriaan D.; Shiels, Holly A.; Steffensen, John F.; Svendsen, Jon C.; Svendsen, Morten B.S.; Teal, Lorna R.; Meer, Van Der Jaap; Wang, Tobias; Wilson, Jonathan M.; Wilson, Rod W.; Metcalfe, Julian D.

    2016-01-01

    The state of the art of research on the environmental physiology of marine fishes is reviewed from the perspective of how it can contribute to conservation of knowledge for conservation of marine fishes is the limited knowledge base; international collaboration is needed to study the environmental

  14. Conservation physiology of marine fishes: state of the art and prospects for policy

    DEFF Research Database (Denmark)

    McKenzie, David J.; Axelsson, Michael; Chabot, Denis

    2016-01-01

    The state of the art of research on the environmental physiology of marine fishes is reviewed from the perspective of how it can contribute to conservation of biodiversity and fishery resources. A major constraint to application of physiological knowledge for conservation of marine fishes is the ...

  15. Electric road vehicles. Technology, state of the art, applications. Elektrische Strassenfahrzeuge. Technik, Entwicklungsstand und Einsatzbereiche

    Energy Technology Data Exchange (ETDEWEB)

    Naunin, D [Technische Univ. Berlin (Germany, F.R.). Inst. fuer Elektronik; Bader, C [Daimler-Benz AG, Stuttgart (Germany, F.R.); Driehorst, F A; Kalberlah, A [Volkswagenwerk AG, Wolfsburg (Germany, F.R.); Fischer, W [Asea Brown Boveri AG, Heidelberg (Germany, F.R.); Kiehne, H A [Zweckverband Elektrotechnik- und Elektronikindustrie e.V. (ZVEI), Hannover (Germany, F.R.). Fachverband Batter

    1989-01-01

    The book discusses (1) economic and traffic policy aspects; (2) new battery systems; (3) different motor concepts; (4) possibilities and problems of serial production; (5) present applications in spas and chances for future applications. The latest state of the art and of the current discussion are presented. (orig./HP) With 139 figs.

  16. EVALUATION OF THE STATE-OF-THE-ART CONTAMINATED SEDIMENT TRANSPORT AND FATE MODELING SYSTEM

    Science.gov (United States)

    Modeling approaches for evaluating the transport and fate of sediment and associated contaminants are briefly reviewed. The main emphasis is on: 1) the application of EFDC (Environmental Fluid Dynamics Code), the state-of-the-art contaminated sediment transport and fate public do...

  17. Some Aspects of the State-of-the-Arts in Biomedical Science ...

    African Journals Online (AJOL)

    Summary: In the biomedical sciences, there is need to generate solutions for Africa's health and economic problems through the impact of university research. To guide organizational transformation, the author here presents some aspects of the state-of-the-arts of biomedical science research in advanced countries using a ...

  18. Dynamic Test of a Collision Post of a State-of-the-Art End Frame Design

    Science.gov (United States)

    2008-09-24

    In support of the Federal Railroad Administration's (FRA) : Railroad Equipment Safety Program, a full-scale dynamic test : of a collision post of a state-of-the-art (SOA) end frame was : conducted on April 16, 2008. The purpose of the test was to : e...

  19. State of the art on historic building insulation materials and retrofit strategies

    DEFF Research Database (Denmark)

    Blumberga, Andra; Kass, Kristaps; Kamendere, Edite

    2016-01-01

    This report provides an analysis and evaluation of a state-of-the-art of internal insulation materials and methods for application in historic buildings, and review on methods, tools and guidelines used as decision making tools for implementation of internal insulation in historic buildings. Hist...

  20. Nuclear scanning microprobe: state of the art, applications and progress trends

    International Nuclear Information System (INIS)

    Ponomarev, A.G.

    2011-01-01

    The physical principles of nuclear scanning microprobe are considered. The analysis of state of the art of the microprobe setup from point of view of its spatial resolution and sensitivity of microanalysis techniques is given. The regions of nuclear microprobe applications are reviewed. The ways of spatial resolution and data acquisition system improvement under consideration of microprobe setup progress trends are considered. (authors)

  1. CEN standards for solar thermal systems - State of the art and expectted impact

    NARCIS (Netherlands)

    Ree, B.G.C. van der; Pauschinger, Th.

    1996-01-01

    Since 1994, the European Committee for Standardization (CEN) Technical Committee TC 312 has been active in producing European Standards for thermal solar energy systems and components. In this paper, an overview of the present State of the Art of the draft standards is presented. These standards

  2. Mathematical E-Learning: State of the Art and Experiences at the Open University of Catalonia

    Science.gov (United States)

    Juan, A.; Huertas, A.; Steegmann, C.; Corcoles, C.; Serrat, C.

    2008-01-01

    In this article we present a review of the state of the art in mathematical e-learning and some personal experiences on this area developed during the last eleven years at the Open University of Catalonia (UOC), a completely online university located in Spain. The article discusses important aspects related to online mathematics courses offered in…

  3. Integrated Simulation for HVAC Performance Prediction: State-of-the-Art Illustration

    NARCIS (Netherlands)

    Hensen, J.L.M.; Clarke, J.A.

    2000-01-01

    This paper aims to outline the current state-of-the-art in integrated building simulation for performance prediction of heating, ventilating and air-conditioning (HVAC) systems. The ESP-r system is used as an example where integrated simulation is a core philosophy behind the development. The

  4. Pragmatics: The State of the Art: An Online Interview with Keith Allan

    Science.gov (United States)

    Allan, Keith; Salmani Nodoushan, Mohammad Ali

    2015-01-01

    This interview was conducted with Professor Keith Allan with the aim of providing a brief but informative summary of the state of the art of pragmatics. In providing answers to the interview questions, Professor Allan begins with a definition of pragmatics as it is practiced today, i.e., the study of the meanings of utterances with attention to…

  5. Solid Waste Processing. A State-of-the-Art Report on Unit Operations and Processes.

    Science.gov (United States)

    Engdahl, Richard B.

    The importance and intricacy of the solid wastes disposal problem and the need to deal with it effectively and economically led to the state-of-the-art survey covered by this report. The material presented here was compiled to be used by those in government and private industry who must make or implement decisions concerning the processing of…

  6. State of the art-hydraulic yaw systems for wind turbines

    DEFF Research Database (Denmark)

    Stubkier, Søren; Pedersen, Henrik C.; Andersen, Torben Ole

    2011-01-01

    This paper addresses the yawing systems of Horizontal Axis Wind Turbines (HAWT’s). HAWT’s represents close to all of the commercial large wind turbines sold today and must be considered state-of-the art within wind turbine technology. Two choices exists when considering components for the active ...

  7. State-of-the-art methodology of forest inventory: a symposium proceedings.

    Science.gov (United States)

    Vernon J. LaBau; Tiberius Cunia

    1990-01-01

    The state-of-the-art of forest inventory methodology, being closely integrated with the fast-moving, high technology computer world, has been changing at a rapid pace over the past decade. Several successful conferences were held during the 1980s with the goal and purpose of staying abreast of such change. This symposium was conceived, not just with the idea of helping...

  8. A Comparative Analysis of Internal Communication and Public Relations Audits. State of the Art.

    Science.gov (United States)

    Dozier, David M.; Hellweg, Susan A.

    A review of current literature regarding the state of the art in the conduct of internal communication and public relations audits by public relations practitioners reveals that these two related measurement activities are of considerable importance to the practice of public relations. Public relations audits are concerned with exploratory…

  9. State-of-the-Art in GPU-Based Large-Scale Volume Visualization

    KAUST Repository

    Beyer, Johanna

    2015-05-01

    This survey gives an overview of the current state of the art in GPU techniques for interactive large-scale volume visualization. Modern techniques in this field have brought about a sea change in how interactive visualization and analysis of giga-, tera- and petabytes of volume data can be enabled on GPUs. In addition to combining the parallel processing power of GPUs with out-of-core methods and data streaming, a major enabler for interactivity is making both the computational and the visualization effort proportional to the amount and resolution of data that is actually visible on screen, i.e. \\'output-sensitive\\' algorithms and system designs. This leads to recent output-sensitive approaches that are \\'ray-guided\\', \\'visualization-driven\\' or \\'display-aware\\'. In this survey, we focus on these characteristics and propose a new categorization of GPU-based large-scale volume visualization techniques based on the notions of actual output-resolution visibility and the current working set of volume bricks-the current subset of data that is minimally required to produce an output image of the desired display resolution. Furthermore, we discuss the differences and similarities of different rendering and data traversal strategies in volume rendering by putting them into a common context-the notion of address translation. For our purposes here, we view parallel (distributed) visualization using clusters as an orthogonal set of techniques that we do not discuss in detail but that can be used in conjunction with what we present in this survey. © 2015 The Eurographics Association and John Wiley & Sons Ltd.

  10. State-of-the-Art in GPU-Based Large-Scale Volume Visualization

    KAUST Repository

    Beyer, Johanna; Hadwiger, Markus; Pfister, Hanspeter

    2015-01-01

    This survey gives an overview of the current state of the art in GPU techniques for interactive large-scale volume visualization. Modern techniques in this field have brought about a sea change in how interactive visualization and analysis of giga-, tera- and petabytes of volume data can be enabled on GPUs. In addition to combining the parallel processing power of GPUs with out-of-core methods and data streaming, a major enabler for interactivity is making both the computational and the visualization effort proportional to the amount and resolution of data that is actually visible on screen, i.e. 'output-sensitive' algorithms and system designs. This leads to recent output-sensitive approaches that are 'ray-guided', 'visualization-driven' or 'display-aware'. In this survey, we focus on these characteristics and propose a new categorization of GPU-based large-scale volume visualization techniques based on the notions of actual output-resolution visibility and the current working set of volume bricks-the current subset of data that is minimally required to produce an output image of the desired display resolution. Furthermore, we discuss the differences and similarities of different rendering and data traversal strategies in volume rendering by putting them into a common context-the notion of address translation. For our purposes here, we view parallel (distributed) visualization using clusters as an orthogonal set of techniques that we do not discuss in detail but that can be used in conjunction with what we present in this survey. © 2015 The Eurographics Association and John Wiley & Sons Ltd.

  11. The LIFE Laser Design in Context: A Comparison to the State-of-the-Art

    International Nuclear Information System (INIS)

    Deri, R.J.; Bayramian, A.J.; Erlandson, A.C.

    2011-01-01

    The current point design for the LIFE laser leverages decades of solid-state laser development in order to achieve the performance and attributes required for inertial fusion energy. This document provides a brief comparison of the LIFE laser point design to other state-of-the-art solid-state lasers. Table I compares the attributes of the current LIFE laser point design to other systems. the state-of-the-art for single-shot performance at fusion-relevant beamline energies is exemplified by performance observed on the National Ignition Facility. The state-of-the-art for high average power is exemplified by the Northrup Grumman JHPSSL laser. Several items in Table I deal with the laser efficiency; a more detailed discussion of efficiency can be found in reference 5. The electrical-to-optical efficiency of the LIFE design exceeds that of reference 4 due to the availability of higher efficiency laser diode pumps (70% vs. ∼50% used in reference 4). LIFE diode pumps are discussed in greater detail in reference 6. The 'beam steering' state of the art is represented by the deflection device that will be used in the LIFE laser, not a laser system. Inspection of Table I shows that most LIFE laser attributes have already been experimentally demonstrated. The two cases where the LIFE design is somewhat better than prior experimental work do not involve the development of new concepts: beamline power is increased simply by increasing aperture (as demonstrated by the power/aperture comparison in Table I), and efficiency increases are achieved by employing state-of-the-art diode pumps. In conclusion, the attributes anticipated for the LIFE laser are consistent with the demonstrated performance of existing solid-state lasers.

  12. Simulation of pollutants transfer in soils - State-of-the-art. State-of-the-art of the simulation of pollutants transfer in soils - Final report

    International Nuclear Information System (INIS)

    Bourgois, J.; Vaillant, Herve; Moszkowicz, P.; Alimi Ichola, Ibrahim; Foret, Suzanne

    1997-02-01

    Industrial companies use and produce numerous substances which can induce a pollution of our environment and especially of soil and groundwater. Thus, it's necessary to estimate the risk of an environmental impact from an accidental or chronic, real or potential pollution. Modelling, which allow the simulation of pollutant migration, can be used as a decision support system, either for the pollution control and prevention of the resource, or for the monitoring of the remediation of polluted sites. In the first part of this study, we established a state of the art on modelling of pollutant migration in soils. In the second part, we focused on the main simulation tools currently available on the market, and on the main agencies or laboratories working on this subject, especially in France. At the end of this study, we drew some conclusions concerning modelling of pollutant migration in soils and the main points which will form the subject of further studies: - sensitivity analysis of model to input parameters and ranking of the main parameters, - achievement of a database on the state of the art of the results on modelling realized on case studies, - development of a mobility indicator of pollutant in soil, - application field and relevance of the models. (authors)

  13. Hybrid Histogram Descriptor: A Fusion Feature Representation for Image Retrieval.

    Science.gov (United States)

    Feng, Qinghe; Hao, Qiaohong; Chen, Yuqi; Yi, Yugen; Wei, Ying; Dai, Jiangyan

    2018-06-15

    Currently, visual sensors are becoming increasingly affordable and fashionable, acceleratingly the increasing number of image data. Image retrieval has attracted increasing interest due to space exploration, industrial, and biomedical applications. Nevertheless, designing effective feature representation is acknowledged as a hard yet fundamental issue. This paper presents a fusion feature representation called a hybrid histogram descriptor (HHD) for image retrieval. The proposed descriptor comprises two histograms jointly: a perceptually uniform histogram which is extracted by exploiting the color and edge orientation information in perceptually uniform regions; and a motif co-occurrence histogram which is acquired by calculating the probability of a pair of motif patterns. To evaluate the performance, we benchmarked the proposed descriptor on RSSCN7, AID, Outex-00013, Outex-00014 and ETHZ-53 datasets. Experimental results suggest that the proposed descriptor is more effective and robust than ten recent fusion-based descriptors under the content-based image retrieval framework. The computational complexity was also analyzed to give an in-depth evaluation. Furthermore, compared with the state-of-the-art convolutional neural network (CNN)-based descriptors, the proposed descriptor also achieves comparable performance, but does not require any training process.

  14. Summary of State-of-the-Art Power Conversion Systems for Energy Storage Applications

    Energy Technology Data Exchange (ETDEWEB)

    Atcitty, S.; Gray-Fenner, A.; Ranade, S.

    1998-09-01

    The power conversion system (PCS) is a vital part of many energy storage systems. It serves as the interface between the storage device, an energy source, and an AC load. This report summarizes the results of an extensive study of state-of-the-art power conversion systems used for energy storage applications. The purpose of the study was to investigate the potential for cost reduction and performance improvement in these power conversion systems and to provide recommendations for fiture research and development. This report provides an overview of PCS technology, a description of several state-of-the-art power conversion systems and how they are used in specific applications, a summary of four basic configurations for l:he power conversion systems used in energy storage applications, a discussion of PCS costs and potential cost reductions, a summary of the stancku-ds and codes relevant to the technology, and recommendations for future research and development.

  15. The state-of-the-art in research on Science teaching for deaf students

    Directory of Open Access Journals (Sweden)

    Ronaldo Santos Santana

    2018-05-01

    Full Text Available This study aimed to highlight the state-of-the-art in research on Science teaching for deaf students from 2012 to 2017, in order to outline an overview of the latest studies in the area, as well as their trends and main considerations. For that, a state-of-the-art research was carried out and, for the construction of the data corpus, abstracts of papers published in scientific journals, course conclusion papers, Masters thesis and Doctoral dissertations were used. From the data analysis, categories were elaborated and trends and challenges in the field were made explicit. The results demonstrate that research in this field is in imminent growth and they are being articulated to the theoretical frameworks that underpin the teaching of Science for hearing students.

  16. Groundwater movements around a repository. Phase 1, State of the art and detailed study plan

    International Nuclear Information System (INIS)

    Lindblom, U.

    1977-02-01

    The report was prepared as the first phase of a study of the groundwater movements around a repository for spent nuclear fuel in the precambrian bedrock of Sweden. The objectives of these studies are to provide a state of the art review of groundwater slow in the region of a repository in granitic rock, in order to provide a basis for long term containment assessments and to prepare a detailed study plan for the continuation of the project. The different processes affecting the groundwater situation for containment are given. A state of the art review of the fluid flow, geochemical, heat transfer and rock mechanics processes as they relate to containment is presented. A detailed study plan to provide a comprehensive assessment of the hydrogeological regime around the repository during its lifetime is also presented. The groundwater flow fields will provide a basis for subsequent long term containment studies. (L.B.)

  17. State-of-the-art report on the theoretical modeling of interfacial area concentration

    International Nuclear Information System (INIS)

    Lee, Won Jae; Euh, Dong Jin

    1998-03-01

    Classical approaches based on experimental correlations and the mechanistic approaches based on the interfacial area concentration were reviewed. The study focuses on the state-of-the-art researches based on the mechanistic modeling of the interfacial area concentration. The investigation is performed by classifying the mechanistic modeling approaches into those using the number density transport equations supported with a simple algebraic relation for obtaining interfacial area concentration and those using the direct interfacial area transport equations. The modeling approaches are subdivided into one group and multi-group models. The state-of-the-art source terms of transport equations are also investigated for their applicability and limitations. (author). 62 refs., 6 tabs., 49 figs

  18. State of the art on construction automation and robotic system in domestic and foreign construction industry

    International Nuclear Information System (INIS)

    Lee, Sung Uk; Seo, Yong Chil; Jung, Seung Ho; Cho, Jai Wan; Choi, Young Soo

    2007-08-01

    In this report, we review the existing concept of construction automation and also survey the state of the art on construction automation and robotic system in domestic and foreign construction industry. On the basis of the result of review and survey, we want to suggest an applicable robotic technology to construction industry and points to be duly considered for activating construction automation. We investigate the state of the art on construction automation and robotic system in domestic and foreign construction industry and also applicable area and direction of domestic construction automation and robotic system. We hope that construction automation and robotic technology, which are improved rapidly nowadays, can contribute to the growth of construction industry

  19. Localized excitations in nonlinear complex systems current state of the art and future perspectives

    CERN Document Server

    Cuevas-Maraver, Jesús; Frantzeskakis, Dimitri; Karachalios, Nikos; Kevrekidis, Panayotis; Palmero-Acebedo, Faustino

    2014-01-01

    The study of nonlinear localized excitations is a long-standing challenge for research in basic and applied science, as well as engineering, due to their importance in understanding and predicting phenomena arising in nonlinear and complex systems, but also due to their potential for the development and design of novel applications. This volume is a compilation of chapters representing the current state-of-the-art on the field of localized excitations and their role in the dynamics of complex physical systems.

  20. Fast reactors in Russia: State of the art and trends of development

    International Nuclear Information System (INIS)

    Poplavsky, V.M.; Ashurko, Yu.M.; Zverev, K.V.; Oshkanov, N.N.; Korol'kov, A.S.; Filin, A.I.

    2002-01-01

    This status report contains the following: facts on nuclear power in Russia from 2001-2002; plans for further development of nuclear power; state of the art on operation of fast reactors in 2002, namely BN-600, experimental reactors BOR-60 and BR-10; construction of NPP BN-800; participation in activities on BN-350 reactor decommissioning; description of trends of design studies in the field of fast reactors and accelerator driven systems

  1. State of the art of numerical modeling of thermohydrologic flow in fractured rock mass

    International Nuclear Information System (INIS)

    Wang, J.S.Y.; Tsang, C.F.; Sterbentz, R.A.

    1983-01-01

    The state of the art of numerical modeling of thermohydrologic flow in fractured rock masses is reviewed and a comparative study is made of several models which have been developed in nuclear waste isolation, geothermal energy, ground-water hydrology, petroleum engineering, and other geologic fields. The general review is followed by separate summaries of the main characteristics of the governing equations, numerical solutions, computer codes, validations, and applications for each model

  2. On the impact of optimisation models in maintenance decision making: the state of the art

    International Nuclear Information System (INIS)

    Dekker, Rommert; Scarf, Philip A.

    1998-01-01

    In this paper we discuss the state of the art in applications of maintenance optimisation models. After giving a short introduction to the area, we consider several ways in which models may be used to optimise maintenance, such as case studies, operational and strategic decision support systems, and give examples of each of them. Next we discuss several areas where the models have been applied successfully. These include civil structure and aeroplane maintenance. From a comparative point of view, we discuss future prospects

  3. State of the art/science: Visual methods and information behavior research

    DEFF Research Database (Denmark)

    Hartel, Jenna; Sonnenwald, Diane H.; Lundh, Anna

    2012-01-01

    This panel reports on methodological innovation now underway as information behavior scholars begin to experiment with visual methods. The session launches with a succinct introduction to visual methods by Jenna Hartel and then showcases three exemplar visual research designs. First, Dianne Sonne...... will have gained: knowledge of the state of the art/science of visual methods in information behavior research; an appreciation for the richness the approach brings to the specialty; and a platform to take new visual research designs forward....

  4. State-of-the-art of fiber-reinforced polymers in additive manufacturing technologies

    DEFF Research Database (Denmark)

    Hofstätter, Thomas; Pedersen, David Bue; Tosello, Guido

    2017-01-01

    Additive manufacturing technologies have received a lot of attention in recent years for their use in multiple materials such as metals, ceramics, and polymers. The aim of this review article is to analyze the technology of fiber-reinforced polymers and its implementation with additive...... manufacturing. This article reviews recent developments, ideas, and state-of-the-art technologies in this field. Moreover, it gives an overview of the materials currently available for fiber-reinforced material technology....

  5. The state of the art of numerical modeling of thermohydrologic flow in fractured rock masses

    International Nuclear Information System (INIS)

    Wang, J.S.Y.; Sterbentz, R.A.; Tsang, C.F.

    1982-01-01

    The state of the art of numerical modeling of thermohydrologic flow in fractured rock masses is reviewed and a comparative study is made of several models which have been developed in nuclear waste isolation, geothermal energy, ground water hydrology, petroleum engineering, and other geologic fields. The general review is followed by individual summaries of each model and the main characteristics of its governing equations, numerical solutions, computer codes, validations, and applications

  6. Curriculum vitae method in science policy and research evaluation: the state-of-the-art

    OpenAIRE

    Carolina Cañibano; Barry Bozeman

    2009-01-01

    This is a state-of-the-art assessment for a small but burgeoning research approach, use of curricula vitae in research evaluation. The accumulated research remains sufficiently modest for us to consider nearly all published studies and the full range of research purposes to which CV analysis has been applied. CV analysis has been theory-driven, and theory and tools have increasingly converged. Advances in method and technique have been abetted especially by the push for a scientific and techn...

  7. The Brazilian state-of-the-art of hydrolysis; Estado da arte da hidrolise no Brasil

    Energy Technology Data Exchange (ETDEWEB)

    Carioca, Jose Osvaldo Beserra; Paula, Haroldo Cesar Beserra de; Lal Arora, Harbans; Selvam, P.V. Pannir [Nucleo de Fontes Nao-Convencionais de Energia, Fortaleza, CE, (Brazil)

    1988-12-31

    This paper presents a study of the state-of-the-art of technologies developed for acid and enzymatic hydrolysis of lignin and cellulose materials in Brazil. The information collected leads us to conclude that Brazil has achieved a high level of technological development. However, the industrial projects for production of alcohol from cassava have not proved successful due mainly to lack of agricultural experience and its low productivity. (author) 26 refs., 13 figs., 2 tabs.

  8. State of the art in HGPT (Heuristically Based Generalized Perturbation) methodology

    International Nuclear Information System (INIS)

    Gandini, A.

    1993-01-01

    A distinctive feature of heuristically based generalized perturbation theory (HGPT) methodology consists in the systematic use of importance conservation concepts. As well known, this use leads to fundamental reciprocity relationships from which perturbation, or sensitivity, expressions can be derived. The state of the art of the HGPT methodology is here illustrated. The application to a number of specific nonlinear fields of interest is commented. (author)

  9. State-of-the art for production of fertilizers with regard to the IPPC-directive

    International Nuclear Information System (INIS)

    Wiesenberger, H.

    2002-01-01

    In the following section general and process-specific measures for the reduction of waste gas and waste water emissions as well as achievable emission levels for the production of fertilizers are summarized, which should be taken into account when considering state-of-the-art. As far as it is not explicitly noted, measures are applicable and emission levels are achievable for both new and existing plants. (author)

  10. Preface: 2nd Workshop on the State of the Art in Nuclear Cluster Physics

    International Nuclear Information System (INIS)

    Descouvemont, P.; Dufour, M.; Sparenberg, J.-M.

    2011-01-01

    The 2nd workshop on the "State of the Art in Nuclear Cluster Physics" (SOTANCP2) took place on May 25-28, 2010, at the Universite Libre de Bruxelles (Brussels, Belgium). The first workshop of this series was held in Strasbourg (France) in 2008. The purpose of SOTANCP2 was to promote the exchange of ideas and to discuss new developments in Clustering Phenomena in Nuclear Physics and Nuclear Astrophysics both from a theoretical and from an experimental point of view

  11. State of the art on hydrogen passive auto-catalytic recombiner (european union Parsoar project)

    International Nuclear Information System (INIS)

    Arnould, F.; Bachellerie, E.; Auglaire, M.; Boeck, B. de; Braillard, O.; Eckardt, B.; Ferroni, F.; Moffett, R.; Van Goethem, G.

    2001-01-01

    This paper presents an overview of the European Union PARSOAR project, which consists in carrying out a state of the art on hydrogen passive auto-catalytic recombiner (PAR) and a handbook guide for implementing these devices in nuclear power plants. This work is performed in the area ''Operational Safety of Existing Installations'' of the key action ''Nuclear Fission'' of the fifth Euratom Framework Programme (1998-2002). (author)

  12. State of the art on hydrogen passive auto-catalytic recombiner (european union Parsoar project)

    Energy Technology Data Exchange (ETDEWEB)

    Arnould, F.; Bachellerie, E. [Technicatome, 13 - Aix en Provence (France); Auglaire, M. [Tractebel Energy Engineering, Brussels (Belgium); Boeck, B. de [Association Vincotte Nuclear, Brussels (Belgium); Braillard, O. [CEA Cadarache, 13 - Saint Paul lez Durance (France); Eckardt, B. [Siemens AG, Offenbach am Main (Germany); Ferroni, F. [Electrowatt Engineering Limited, Zurich (Switzerland); Moffett, R. [Atomic Energy Canada Limited, Pinawa (Canada); Van Goethem, G. [European Commission, Brussels (Belgium)

    2001-07-01

    This paper presents an overview of the European Union PARSOAR project, which consists in carrying out a state of the art on hydrogen passive auto-catalytic recombiner (PAR) and a handbook guide for implementing these devices in nuclear power plants. This work is performed in the area ''Operational Safety of Existing Installations'' of the key action ''Nuclear Fission'' of the fifth Euratom Framework Programme (1998-2002). (author)

  13. INFORMATION STORAGE AND RETRIEVAL, A STATE-OF-THE-ART REPORT

    Science.gov (United States)

    The objective of the study was to compile relevant background and interpretive material and prepare a state-of-the-art report which would put the...to-person communications. Section III presents basic IS and R concepts and techniques. It traces the history of traditional librarianship through...the process of communication between the originators and users of information. Section V categorizes the information system operations required to

  14. Alkali activated materials state-of-the-art report, RILEM TC 224-AAM

    CERN Document Server

    Deventer, Jannie

    2014-01-01

    This is a State of the Art Report resulting from the work of RILEM Technical Committee 224-AAM in the period 2007-2013. The Report summarises research to date in the area of alkali-activated binders and concretes, with a particular focus on the following areas: binder design and characterisation, durability testing, commercialisation, standardisation, and providing a historical context for this rapidly-growing research field.

  15. A state of the art review of vitrification of high level waste in Europe

    International Nuclear Information System (INIS)

    Heimerl, W.

    This paper gives a review of the state-of-the-art of the development and demonstration of vitrification processes for high level radioactive waste solutions on an industrial scale in four European countries (France, United Kingdom, Federal Republic of Germany and Belgium). Historical development, experiences and operations present status and future plans are presented. Three of the processes which seem to be of major importance are described (AVM-France, HARVEST-United Kingdom, PAMELA Germany/Belgium). (author)

  16. Link Prediction in Social Networks: the State-of-the-Art

    OpenAIRE

    Wang, Peng; Xu, Baowen; Wu, Yurong; Zhou, Xiaoyu

    2014-01-01

    In social networks, link prediction predicts missing links in current networks and new or dissolution links in future networks, is important for mining and analyzing the evolution of social networks. In the past decade, many works have been done about the link prediction in social networks. The goal of this paper is to comprehensively review, analyze and discuss the state-of-the-art of the link prediction in social networks. A systematical category for link prediction techniques and problems ...

  17. Security of embedded automotive networks: state of the art and a research proposal

    OpenAIRE

    Studnia , Ivan; Nicomette , Vincent; Alata , Eric; Deswarte , Yves; Kaâniche , Mohamed; Laarouchi , Youssef

    2013-01-01

    International audience; Embedded electronic components are nowadays a prominent part of a car's architecture. Moreover, modern cars are now able to communicate with other devices through many wired or wireless interfaces. As a consequence, the security of embedded systems in cars has become a main concern for the manufacturers. This paper aims at 1) presenting a short overview of the current attacks already known and experimented against vehicles as well as the current state of the art of the...

  18. Seismic response of buried pipelines: a state-of-the-art review

    International Nuclear Information System (INIS)

    Datta, T.K.

    1999-01-01

    A state-of-the-art review of the seismic response of buried pipelines is presented. The review includes modeling of soil-pipe system and seismic excitation, methods of response analysis of buried pipelines, seismic behavior of buried pipelines under different parametric variations, seismic stresses at the bends and intersections of network of pipelines. pipe damage in earthquakes and seismic risk analysis of buried pipelines. Based on the review, the future scope of work on the subject is outlined. (orig.)

  19. Plugging wells for abandonment: a state-of-the-art study and recommended procedures

    International Nuclear Information System (INIS)

    Herndon, J.; Smith, D.K.

    1976-09-01

    The state-of-the-art of borehole plugging of abandoned oil wells and the tools and materials used are discussed. Special problems encountered are considered and several case studies are outlined. The special procedures which must be followed if the plugged borehole is to be considered as a repository for radioactive wastes are discussed and special recommendations are made. A state-by-state summary is given of the regulatory requirements for borehole plugging

  20. Multi-Wave and Hybrid Imaging Techniques: A New Direction for Nondestructive Testing and Structural Health Monitoring

    Directory of Open Access Journals (Sweden)

    Yuhua Cheng

    2013-11-01

    Full Text Available In this article, the state-of-the-art multi-wave and hybrid imaging techniques in the field of nondestructive evaluation and structural health monitoring were comprehensively reviewed. A new direction for assessment and health monitoring of various structures by capitalizing the advantages of those imaging methods was discussed. Although sharing similar system configurations, the imaging physics and principles of multi-wave phenomena and hybrid imaging methods are inherently different. After a brief introduction of nondestructive evaluation (NDE , structure health monitoring (SHM and their related challenges, several recent advances that have significantly extended imaging methods from laboratory development into practical applications were summarized, followed by conclusions and discussion on future directions.

  1. State of the art on the probabilistic safety assessment (P.S.A.)

    International Nuclear Information System (INIS)

    Devictor, N.; Bassi, A.; Saignes, P.; Bertrand, F.

    2008-01-01

    The use of Probabilistic Safety Assessment (PSA) is internationally increasing as a means of assessing and improving the safety of nuclear and non-nuclear facilities. To support the development of a competence on Probabilistic Safety Assessment, a set of states of the art regarding these tools and their use has been made between 2001 and 2005, in particular on the following topics: - Definition of the PSA of level 1, 2 and 3; - Use of PSA in support to design and operation of nuclear plants (risk-informed applications); - Applications to Non Reactor Nuclear Facilities. The report compiled in a single document these states of the art in order to ensure a broader use; this work has been done in the frame of the Project 'Reliability and Safety of Nuclear Facility' of the Nuclear Development and Innovation Division of the Nuclear Energy Division. As some of these states of the art have been made in support to exchanges with international partners and were written in English, a section of this document is written in English. This work is now applied concretely in support to the design of 4. Generation nuclear systems as Sodium-cooled Fast Reactors and especially Gas-cooled Fast Reactor, that have been the subject of communications during the conferences ANS (Annual Meeting 2007), PSA'08, ICCAP'08 and in the journal Science and Technology of Nuclear Installations. (authors)

  2. Grate monitoring systems, state of the art; Metoder foer rosteroevervakning, dagslaegesbestaemning

    Energy Technology Data Exchange (ETDEWEB)

    Blom, Elisabet [Aaf Processdesign AB, Linkoeping (Sweden)

    2001-01-01

    During a number of years research and development projects have been made to present methods of monitoring the grate in a grate fired boiler. The monitoring is interesting in order to be able to increase efficiency, increase burn-out of ash, improve the status of emissions, improve transportation of ash and fuel through the furnace, reduce costs for operation and maintenance, handle greater loads etc. Improvement of the combustion has been concentrated to the development of the gas phase combustion. In the past few years the computer development has progressed rapidly and the use of optical monitoring methods have been made possible for monitoring grates. To analyse state of the art of optical grate monitoring systems three different methods have been used, literature search, inquiry where plant owners were asked if they have used grate monitoring systems and if so what experiences they have, and interviews with scientists and users. The inquiry investigation was made during spring 2000 and supplemented with a few known users of grate monitoring systems in august 2000. The interviews were made during august 2000. The methods which have been examined are: Video monitoring; Computer vision; IR-pyrometry; IR-camera technology; Laser measuring methods; Acoustic pyrometry. The survey showed that video monitoring is useful to monitor the fuel bed and an aid to the operators. A good cooling and cleansing system is essential to make the system reliable. If the system is aided with computer vision the computer will show numbers which can be used in the control system. These have been tried at a couple of sites but the system is still being developed and no sites uses this function fully automated. Infrared measurements have been tried in number of research projects. The IR-pyrometer technique is good for measuring temperature but the reliability is too low for some of the users. IR-cameras are used in several waste incineration plants to control the combustion. The systems

  3. Membrane Separation Processes for Post-Combustion Carbon Dioxide Capture: State of the Art and Critical Overview

    Directory of Open Access Journals (Sweden)

    Belaissaoui Bouchra

    2014-11-01

    Full Text Available Membrane processes have been initially seldom considered within a post-combustion carbon dioxide capture framework. More traditional processes, particularly gas-liquid absorption in chemical solvents, are often considered as the most appropriate solution for the first generation of technologies. In this paper, a critical state of the art of gas separation membranes for CO2 capture is proposed. In a first step, the key performances (selectivity, permeability of different membrane materials such as polymers, inorganic membranes, hybrid matrices and liquid membranes, including recently reported results, are reviewed. In a second step, the process design characteristics of a single stage membrane unit are studied. Purity and energy constraints are analysed as a function of operating conditions and membrane materials performances. The interest of multistage and hybrid systems, two domains which have not sufficiently investigated up to now, are finally discussed. The importance of technico-economical analyses is highlighted in order to better estimate the optimal role of membranes for CCS applications.

  4. Clay-Inspired MXene-Based Electrochemical Devices and Photo-Electrocatalyst: State-of-the-Art Progresses and Challenges.

    Science.gov (United States)

    Wang, Hou; Wu, Yan; Yuan, Xingzhong; Zeng, Guangming; Zhou, Jin; Wang, Xin; Chew, Jia Wei

    2018-03-01

    MXene, an important and increasingly popular category of postgraphene 2D nanomaterials, has been rigorously investigated since early 2011 because of advantages including flexible tunability in element composition, hydrophobicity, metallic nature, unique in-plane anisotropic structure, high charge-carrier mobility, tunable band gap, and favorable optical and mechanical properties. To fully exploit these potentials and further expand beyond the existing boundaries, novel functional nanostructures spanning monolayer, multilayer, nanoparticles, and composites have been developed by means of intercalation, delamination, functionalization, hybridization, among others. Undeniably, the cutting-edge developments and applications of clay-inspired 2D MXene platform as electrochemical electrode or photo-electrocatalyst have conferred superior performance and have made significant impact in the field of energy and advanced catalysis. This review provides an overview of the fundamental properties and synthesis routes of pure MXene, functionalized MXene and their hybrids, highlights the state-of-the-art progresses of MXene-based applications with respect to supercapacitors, batteries, electrocatalysis and photocatalysis, and presents the challenges and prospects in the burgeoning field. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  5. The state of the art of flood forecasting - Hydrological Ensemble Prediction Systems

    Science.gov (United States)

    Thielen-Del Pozo, J.; Pappenberger, F.; Salamon, P.; Bogner, K.; Burek, P.; de Roo, A.

    2010-09-01

    Flood forecasting systems form a key part of ‘preparedness' strategies for disastrous floods and provide hydrological services, civil protection authorities and the public with information of upcoming events. Provided the warning leadtime is sufficiently long, adequate preparatory actions can be taken to efficiently reduce the impacts of the flooding. Because of the specific characteristics of each catchment, varying data availability and end-user demands, the design of the best flood forecasting system may differ from catchment to catchment. However, despite the differences in concept and data needs, there is one underlying issue that spans across all systems. There has been an growing awareness and acceptance that uncertainty is a fundamental issue of flood forecasting and needs to be dealt with at the different spatial and temporal scales as well as the different stages of the flood generating processes. Today, operational flood forecasting centres change increasingly from single deterministic forecasts to probabilistic forecasts with various representations of the different contributions of uncertainty. The move towards these so-called Hydrological Ensemble Prediction Systems (HEPS) in flood forecasting represents the state of the art in forecasting science, following on the success of the use of ensembles for weather forecasting (Buizza et al., 2005) and paralleling the move towards ensemble forecasting in other related disciplines such as climate change predictions. The use of HEPS has been internationally fostered by initiatives such as "The Hydrologic Ensemble Prediction Experiment" (HEPEX), created with the aim to investigate how best to produce, communicate and use hydrologic ensemble forecasts in hydrological short-, medium- und long term prediction of hydrological processes. The advantages of quantifying the different contributions of uncertainty as well as the overall uncertainty to obtain reliable and useful flood forecasts also for extreme events

  6. End-of-life vehicle recycling : state of the art of resource recovery from shredder residue.

    Energy Technology Data Exchange (ETDEWEB)

    Jody, B. J.; Daniels, E. J.; Duranceau, C. M.; Pomykala, J. A.; Spangenberger, J. S. (Energy Systems)

    2011-02-22

    vehicles. Many of these materials increase the percentage of shredder residue that must be disposed of, compared with the percentage of metals that are recovered. In addition, the number of hybrid vehicles and electric vehicles on the road is rapidly increasing. This trend will also introduce new materials for disposal at the end of their useful lives, including batteries. Therefore, as the complexity of automotive materials and systems increases, new technologies will be required to sustain and maximize the ultimate recycling of these materials and systems. Argonne National Laboratory (Argonne), the Vehicle Recycling Partnership, LLC. (VRP) of the United States Council for Automotive Research, LLC. (USCAR), and the American Chemistry Council-Plastics Division (ACC-PD) are working to develop technology for recovering materials from end-of-life vehicles, including separating and recovering polymers and residual metals from shredder residue. Several other organizations worldwide are also working on developing technology for recycling materials from shredder residue. Without a commercially viable shredder industry, our nation and the world will most likely face greater environmental challenges and a decreased supply of quality scrap, and thereby be forced to turn to primary ores for the production of finished metals. This will result in increased energy consumption and increased damage to the environment, including increased greenhouse gas emissions. The recycling of polymers, other organics, and residual metals in shredder residue saves the equivalent of over 23 million barrels of oil annually. This results in a 12-million-ton reduction in greenhouse gas emissions. This document presents a review of the state-of-the-art in the recycling of automotive materials.

  7. [Health professionals facing hand hygiene improvement: state-of-the-art strategies versus extended strategies].

    Science.gov (United States)

    Herrera-Usagre, Manuel; Pérez-Pérez, Pastora; Vázquez-Vázquez, Marta; Santana-López, Vicente

    2014-10-01

    The hand hygiene (HH) is one of the preventive practices more .widely and effectively implemented in the control of healthcare associated infections. However, there are several barriers to compliance. To assess which strategy, state-of-the-art strategies (availability of alcohol-based preparations, posters, instructions and training) or extended strategies (feedbacks, formal and informal leadership), are seen as more effective to improve hand hygiene (HH) compliance. Analytical study using a self-completed questionnaire developed by the World Health Organization. 2,068 questionnaires, completed by healthcare professionals (HP) in Andalusia (Spain), were received from 2010 to 2012. Analytical technique: Structural equation modeling and multi group measurement invariance. Once the reliability of the proposed constructs was achieved (Cronbach α=0.73, 0.84, 0.70), it was found that those HP working in centers with the highest level of commitment with HH are those who see extended strategies as more effective (χ2=298.3, df=39, CFI=0.972, TLI=0.961, RMSEA=0.057, SRMR=0.028). Our results have shown that hospitals' HP, compared to primary care HP, see state-of-the-art strategies as more effective, as well as they give less importance to HH, meanwhile nurses, compared to physicians, see effective both strategies. HP contemplate the combination of state-of-the-art and extended strategies as an effective way to improve the HH compliance. In addition, extended strategies are considered more effective amongst the most "advanced" healthcare settings in terms of their commitment to HH. The results highlight the need for commitment at management, collective and individual level in order to maintain patient safety.

  8. A-State-of-the-Art Report on Application of Radiation Technology to Environmental Pollution Control

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jae Kwang; Lee, Myun Joo

    2004-06-15

    Radiation technology has been rapidly developed for decades and its applicability also enlarged to many fields such as environmental protection, medical care, manufacturing industry, agriculture, and bio technology. In this report, we focused on the present situation of the development of radiation facilities and state-of-the-art on application of radiation to environmental pollution control including purification of flue gas, waste water treatment, and recycling of biological waste. We especially discussed the radiation technology for environmental pollution control and described the capability of its application to the industrial plants in Korea.

  9. State-of-the-art techniques for inventory of Great Lakes aquatic habitats and resources

    Science.gov (United States)

    Edsall, Thomas A.; Brock, R.H.; Bukata, R.P.; Dawson, J.J.; Horvath, F.J.; Busch, W.-Dieter N.; Sly, Peter G.

    1992-01-01

    This section of the Classification and Inventory of Great Lakes Aquatic Habitat report was prepared as a series of individually authored contributions that describe, in various levels of detail, state-of-the-art techniques that can be used alone or in combination to inventory aquatic habitats and resources in the Laurentian Great Lakes system. No attempt was made to review and evaluate techniques that are used routinely in limnological and fisheries surveys and inventories because it was felt that users of this document would be familiar with them.

  10. Life cycle impacts and costs of photovoltaic systems: Current state of the art and future outlooks

    Energy Technology Data Exchange (ETDEWEB)

    Raugei, Marco [Environmental Management Research Group, Escola Superior de Commerc Internacional-Universitat Pompeu Fabra, Passeig Pujades 1, 08003 Barcelona (Spain); Frankl, Paolo [Renewable Energy Unit, International Energy Agency, Rue de la Federation 9, 75739 Paris Cedex 15 (France)

    2009-03-15

    The photovoltaic energy sector is rapidly expanding and technological specification for PV has improved dramatically in the last two decades. This paper sketches the current state of the art and drafts three alternative scenarios for the future, in terms of costs, market penetration and environmental performance. According to these scenarios, if economic incentives are supported long enough into the next ten to twenty years, PV looks set for a rosy future, and is likely to play a significant role in the future energy mix, while at the same time contributing to reduce the environmental impact of electricity supply. (author)

  11. Wireless Sensor Network Security Enhancement Using Directional Antennas: State of the Art and Research Challenges.

    Science.gov (United States)

    Curiac, Daniel-Ioan

    2016-04-07

    Being often deployed in remote or hostile environments, wireless sensor networks are vulnerable to various types of security attacks. A possible solution to reduce the security risks is to use directional antennas instead of omnidirectional ones or in conjunction with them. Due to their increased complexity, higher costs and larger sizes, directional antennas are not traditionally used in wireless sensor networks, but recent technology trends may support this method. This paper surveys existing state of the art approaches in the field, offering a broad perspective of the future use of directional antennas in mitigating security risks, together with new challenges and open research issues.

  12. Life cycle impacts and costs of photovoltaic systems: Current state of the art and future outlooks

    International Nuclear Information System (INIS)

    Raugei, Marco; Frankl, Paolo

    2009-01-01

    The photovoltaic energy sector is rapidly expanding and technological specification for PV has improved dramatically in the last two decades. This paper sketches the current state of the art and drafts three alternative scenarios for the future, in terms of costs, market penetration and environmental performance. According to these scenarios, if economic incentives are supported long enough into the next ten to twenty years, PV looks set for a rosy future, and is likely to play a significant role in the future energy mix, while at the same time contributing to reduce the environmental impact of electricity supply. (author)

  13. The state of the art of the impact of sampling uncertainty on measurement uncertainty

    Science.gov (United States)

    Leite, V. J.; Oliveira, E. C.

    2018-03-01

    The measurement uncertainty is a parameter that marks the reliability and can be divided into two large groups: sampling and analytical variations. Analytical uncertainty is a controlled process, performed in the laboratory. The same does not occur with the sampling uncertainty, which, because it faces several obstacles and there is no clarity on how to perform the procedures, has been neglected, although it is admittedly indispensable to the measurement process. This paper aims at describing the state of the art of sampling uncertainty and at assessing its relevance to measurement uncertainty.

  14. The fifth generation computer project state of the art report 111

    CERN Document Server

    Scarrott

    1983-01-01

    The Fifth Generation Computer Project is a two-part book consisting of the invited papers and the analysis. The invited papers examine various aspects of The Fifth Generation Computer Project. The analysis part assesses the major advances of the Fifth Generation Computer Project and provides a balanced analysis of the state of the art in The Fifth Generation. This part provides a balanced and comprehensive view of the development in Fifth Generation Computer technology. The Bibliography compiles the most important published material on the subject of The Fifth Generation.

  15. Seismic design spectra for nuclear power plants, state-of-the-art

    International Nuclear Information System (INIS)

    Michalopoulos, A.P.; Shukla, D.K.

    1976-01-01

    The State-of-the-Art of nuclear power plant design involves the use of design response spectra together with a modal analysis of a mathematical idealization of the actual structure. The design response spectra give the maximum response to ground shaking for a family of single degree-of-freedom viscously damped oscillators. These spectra are usually described as an accelerogram giving ground acceleration as a function of time. The definition of a 'standard' design response spectra is reviewed and illustrated by data relevant to 'hard' or rock sites. Finally, the paper recommends a set of design response spectra applicable to rock sites

  16. State-of-the-art report for solar water heaters in the Netherlands 2008

    International Nuclear Information System (INIS)

    Bosselaar, L.; Blezer, I.

    2009-01-01

    This state-of-the-art report addresses the implementation of solar heat in the Netherlands. The main appliance is the solar boiler for production of warm tap water in households. Other appliances are production of warm tap water in large buildings (e.g. homes for the elderly), heating of dwellings and heating of swimming pools. The aim of this report is to provide an overview of the market and techniques for this technology. Emphasis will be put on solar boilers, but other appliances will also be addressed [nl

  17. State-of-the-art report of spent fuel management technology

    International Nuclear Information System (INIS)

    Ro, S. G.; Park, S. W.; Shin, Y. J. and others

    1998-06-01

    Essential technologies for a long-term management of domestic nuclear fuel have been described in this report. The technologies of interest are advanced processes for spent fuel management, spent fuel examination technology, evaluation of radiation effect on equipment, chemical characterization of spent fuel, and hot cell-related technology state of the art for the above-mentioned technologies has been reviewed and analyzed in detail. As a result, a future R and D direction that seems to be appropriate for us is drawn up in due consideration of in- and out-circumstances encountered with. (author). 304 refs., 28 tabs., 43 figs

  18. Endovascular Interventions for Acute and Chronic Lower Extremity Deep Venous Disease: State of the Art.

    Science.gov (United States)

    Sista, Akhilesh K; Vedantham, Suresh; Kaufman, John A; Madoff, David C

    2015-07-01

    The societal and individual burden caused by acute and chronic lower extremity venous disease is considerable. In the past several decades, minimally invasive endovascular interventions have been developed to reduce thrombus burden in the setting of acute deep venous thrombosis to prevent both short- and long-term morbidity and to recanalize chronically occluded or stenosed postthrombotic or nonthrombotic veins in symptomatic patients. This state-of-the-art review provides an overview of the techniques and challenges, rationale, patient selection criteria, complications, postinterventional care, and outcomes data for endovascular intervention in the setting of acute and chronic lower extremity deep venous disease. Online supplemental material is available for this article.

  19. State-of-the-art Review : Vol. 2A. Responsive Building Elements

    DEFF Research Database (Denmark)

    Blümel, Ernst; Haghighat, Fariborz; Li, Yuguo

    This report resumes and presents the activity done in Subtask A of IEA-ECBCS Annex 44 “Integrating Environmentally Responsive Elements in Buildings” concerning the state of the art review of Responsive Building Elements. It is based on the contributions from the participating countries...... at researchers in the field and gives an overview of how these elements work together with available performance data. It is hoped, that this report will be helpful for researchers in their search for new solutions to the problem of designing and constructing sustainable buildings....

  20. State of the Art Review on Theoretical Tribology of Fluid Power Displacement Machines

    DEFF Research Database (Denmark)

    Cerimagic, Remzija; Johansen, Per; Andersen, Torben O.

    2016-01-01

    machines, and also the work done to validate the theoretical models. This review is not a complete historical account, but aim to describe current trends in fluid power displacement machine tribology. The review considers the rheological models used in the theoretical approaches, the modeling...... and wear mechanisms in the lubricating gaps in fluid power machines is confined to simulation models, as experimental treatments of these mechanisms are very difficult. The aim of this paper is a state of the art review on the theoretical work for the design and optimization of fluid power displacement...... of elastohydrodynamic effects, the modeling of thermal effects, and finally the experimental validation of the theoretical models....

  1. Fractal-Based Methods and Inverse Problems for Differential Equations: Current State of the Art

    Directory of Open Access Journals (Sweden)

    Herb E. Kunze

    2014-01-01

    Full Text Available We illustrate, in this short survey, the current state of the art of fractal-based techniques and their application to the solution of inverse problems for ordinary and partial differential equations. We review several methods based on the Collage Theorem and its extensions. We also discuss two innovative applications: the first one is related to a vibrating string model while the second one considers a collage-based approach for solving inverse problems for partial differential equations on a perforated domain.

  2. An Overview of the State of the Art in Atomistic and Multiscale Simulation of Fracture

    Science.gov (United States)

    Saether, Erik; Yamakov, Vesselin; Phillips, Dawn R.; Glaessgen, Edward H.

    2009-01-01

    The emerging field of nanomechanics is providing a new focus in the study of the mechanics of materials, particularly in simulating fundamental atomic mechanisms involved in the initiation and evolution of damage. Simulating fundamental material processes using first principles in physics strongly motivates the formulation of computational multiscale methods to link macroscopic failure to the underlying atomic processes from which all material behavior originates. This report gives an overview of the state of the art in applying concurrent and sequential multiscale methods to analyze damage and failure mechanisms across length scales.

  3. MECHANISMS IN ENDOCRINOLOGY: Diabetic cardiomyopathy: pathophysiology and potential metabolic interventions state of the art review.

    Science.gov (United States)

    Levelt, Eylem; Gulsin, Gaurav; Neubauer, Stefan; McCann, Gerry P

    2018-04-01

    Heart failure is a major cause of morbidity and mortality in type 2 diabetes. Type 2 diabetes contributes to the development of heart failure through a variety of mechanisms, including disease-specific myocardial structural, functional and metabolic changes. This review will focus on the contemporary contributions of state of the art non-invasive technologies to our understanding of diabetic cardiomyopathy, including data on cardiac disease phenotype, cardiac energy metabolism and energetic deficiency, ectopic and visceral adiposity, diabetic liver disease, metabolic modulation strategies and cardiovascular outcomes with new classes of glucose-lowering therapies. © 2018 The authors.

  4. On the state of the art: risk communication to decision-makers

    International Nuclear Information System (INIS)

    Bier, V.M.

    2001-01-01

    This paper reviews the state of the art on risk communication to decision-makers, with an emphasis on issues involved in communicating technical results. In particular, the paper discusses the treatment of uncertainty, variability, and dependence. It also reviews suggestions from the literature regarding the appropriate format of risk communication messages to decision-makers. Due to the lack of detailed empirical investigations and definitive results about this topic, the paper is not intended to be a comprehensive review, but rather as an exploration of key issues in this area

  5. Flow-induced vibration in LMFBR steam generators: a state-of-the-art review

    International Nuclear Information System (INIS)

    Shin, Y.S.; Wambsganss, M.W.

    1975-05-01

    This state-of-the-art review identifies and discusses existing methods of flow-induced vibration analysis applicable to steam generators, their limitations, and base-technology needs. Also included are discussions of five different LMFBR steam-generator configurations and important design considerations, failure experiences, possible flow-induced excitation mechanisms, vibration testing, and available methods of vibration analysis. The objectives are to aid LMFBR steam-generator designers in making the best possible evaluation of potential vibration in steam-generator internals, and to provide the basis for development of design guidelines to avoid detrimental flow-induced vibration

  6. Thermal solar energy in Spain. State of the art and objectives

    International Nuclear Information System (INIS)

    Glenn, Jaouen

    2006-01-01

    According the Kyoto protocol, Spain has to reduce its CO 2 emissions at 330 millions of tons (a decrease of 18 % from the level of 2003). From the european commission policy, the energy resources will be of 12 % of renewable energies. In this context, Spain developed an energy policy in favor of the solar energy. This document provides information on: the energy market in Spain, the thermal solar energy operating, the CO 2 emissions, the state of the art in the domain in spain, the 2010 objectives, the programs and the assistance, some data on the solar market in comparison with the Europe. (A.L.B.)

  7. Calcific tendinitis of the rotator cuff: state of the art in diagnosis and treatment.

    Science.gov (United States)

    Merolla, Giovanni; Singh, Sanjay; Paladini, Paolo; Porcellini, Giuseppe

    2016-03-01

    Calcific tendinitis is a painful shoulder disorder characterised by either single or multiple deposits in the rotator cuff tendon. Although the disease subsides spontaneously in most cases, a subpopulation of patients continue to complain of pain and shoulder dysfunction and the deposits do not show any signs of resolution. Although several treatment options have been proposed, clinical results are controversial and often the indication for a given therapy remains a matter of clinician choice. Herein, we report on the current state of the art in the pathogenesis, diagnosis and treatment of calcific tendinitis of the rotator cuff.

  8. State of the art of parallel scientific visualization applications on PC clusters

    International Nuclear Information System (INIS)

    Juliachs, M.

    2004-01-01

    In this state of the art on parallel scientific visualization applications on PC clusters, we deal with both surface and volume rendering approaches. We first analyze available PC cluster configurations and existing parallel rendering software components for parallel graphics rendering. CEA/DIF has been studying cluster visualization since 2001. This report is part of a study to set up a new visualization research platform. This platform consisting of an eight-node PC cluster under Linux and a tiled display was installed in collaboration with Versailles-Saint-Quentin University in August 2003. (author)

  9. Panel session on the state of the art in nuclear reactor technology

    International Nuclear Information System (INIS)

    Roche, R.

    1977-01-01

    The state of the art in the technology of pressure vessels and piping of the primary cooling circuit of nuclear steam supply systems is discussed. Design and analysis are considered in the frame of the two types of nuclear reactor retained in France (PWR and the pool type LMFBR). Designing nuclear pressure vessels asks for some more specific Codes and Standards than for conventional vessels, and the stress analysis complementing by a direct comparison between operating loads and failure loads is a mandatory practice in France. As for pool type LMFBR, the structural problems of the nuclear vessel are essentially due to component shape, small thickness, and large stress range

  10. A state-of-the-art passive gamma-ray assay system

    International Nuclear Information System (INIS)

    Sampson, T.E.; Parker, J.L.; Cowder, L.R.; Kern, E.A.; Garcia, D.L.; Ensslin, N.

    1987-01-01

    We report details of the development of a high-accuracy, high-precision system for the non-destructive assay of 235 U in solution. The system can measure samples with concentrations ranging from 0.0001 to 500 g 235 U/l using 200-ml samples at low concentrations, 30-ml samples at high concentrations, and 1000-s measurement times. The accuracy and precision goals of 0.1% were essentially attained for concentrations above 100 g/l. This at-line system, designed for a production plant environment, represents a significant improvement in the state of the art

  11. Massive parallel sequencing in sarcoma pathobiology: state of the art and perspectives.

    Science.gov (United States)

    Brenca, Monica; Maestro, Roberta

    2015-01-01

    Sarcomas are an aggressive and highly heterogeneous group of mesenchymal malignancies with different morphologies and clinical behavior. Current therapeutic strategies remain unsatisfactory. Cytogenetic and molecular characterization of these tumors is resulting in the breakdown of the classical histopathological categories into molecular subgroups that better define sarcoma pathobiology and pave the way to more precise diagnostic criteria and novel therapeutic opportunities. The purpose of this short review is to summarize the state-of-the-art on the exploitation of massive parallel sequencing technologies, also known as next generation sequencing, in the elucidation of sarcoma pathobiology and to discuss how these applications may impact on diagnosis, prognosis and therapy of these tumors.

  12. Building Energy Benchmarking in India: an Action Plan for Advancing the State-of-the-Art

    Energy Technology Data Exchange (ETDEWEB)

    Sarraf, Saket [Centre for Environmental Planning and Technology (CEPT) Univ., Ahmedabad (India); Anand, Shilpi [Centre for Environmental Planning and Technology (CEPT) Univ., Ahmedabad (India); Shukla, Yash [Centre for Environmental Planning and Technology (CEPT) Univ., Ahmedabad (India); Mathew, Paul [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Singh, Reshma [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2014-06-01

    This document describes an action plan for advancing the state of the art of commercial building energy benchmarking in the Indian context. The document is primarily intended for two audiences: (a) Research and development (R&D) sponsors and researchers can use the action plan to frame, plan, prioritize and scope new energy benchmarking R&D in order to ensure that their research is market relevant; (b) Policy makers and program implementers engaged in the deployment of benchmarking and building efficiency rating programmes can use the action plan for policy formulation and enforcement .

  13. Solar water detoxification: state of the art of the research in Spain

    International Nuclear Information System (INIS)

    Perez Martinez, M.; Cuesta Santianes, J.; Cabrera Jimenez, J. A.; Garcia Garcia, D.; Trevino Sanchez, A. C.; Berges Garcia, A.

    2010-01-01

    The CIEMAT's Foresight and Technology Watch Unit, whose technology watch management system is certified by Aenor as per standards UNE 16006:2006, has developed this study in order to review the state of the art of national research on solar water detoxification. to reach this goal, data bases of scientific publications, research projects and patents have been used. The technology watch information management solution VICUBO, developed by E-intelligent, was used as support tool for the afore-mentioned standard. (Author) 3 refs.

  14. Preliminary power train design for a state-of-the-art electric vehicle

    Science.gov (United States)

    Ross, J. A.; Wooldridge, G. A.

    1978-01-01

    The state-of-the-art (SOTA) of electric vehicles built since 1965 was reviewed to establish a base for the preliminary design of a power train for a SOTA electric vehicle. The performance of existing electric vehicles were evaluated to establish preliminary specifications for a power train design using state-of-the-art technology and commercially available components. Power train components were evaluated and selected using a computer simulation of the SAE J227a Schedule D driving cycle. Predicted range was determined for a number of motor and controller combinations in conjunction with the mechanical elements of power trains and a battery pack of sixteen lead-acid batteries - 471.7 kg at 0.093 MJ/Kg (1040 lbs. at 11.7 Whr/lb). On the basis of maximum range and overall system efficiency using the Schedule D cycle, an induction motor and 3 phase inverter/controller was selected as the optimum combination when used with a two-speed transaxle and steel belted radial tires. The predicted Schedule D range is 90.4 km (56.2 mi). Four near term improvements to the SOTA were identified, evaluated, and predicted to increase range approximately 7%.

  15. The state of the art of wind energy conversion systems and technologies: A review

    International Nuclear Information System (INIS)

    Cheng, Ming; Zhu, Ying

    2014-01-01

    Highlights: • This paper reviews the state of the art of wind energy conversion systems. • Different types of common wind energy conversion systems are classified and compared. • The four most popular MPPT control methods are reviewed and compared. • The latest development of wind energy conversion technologies is introduced. • Future trends of the wind energy conversion technologies are discussed. - Abstract: This paper gives a comprehensive review of the state of the art of wind energy conversion systems (WECS) and technologies, with an emphasis on wind power generator and control. First, different types of common WECSs are classified according to their features and drive train types. The WECSs are compared on the basis of the volume, weight, cost, efficiency, system reliability and fault ride through capability. The maximum power point tracking (MPPT) control, which aims to make the generator speed meet an optimum value to ensure the maximum energy yield, plays a key role in the variable speed WECSs. A comprehensive review and comparison of the four most popular MPPT control methods are carried out and improvements for each method are presented. Furthermore, the latest development of wind energy conversion technologies is introduced, such as the brushless doubly fed induction generator (BDFIG), the stator permanent magnet synchronous generators, the magnetic-geared generators, dual power flow WECS with the electrical variable transmission (EVT) machine, and direct grid-connected WECS. Finally, the future trends of the technologies are discussed

  16. Fine pitch thermosonic wire bonding: analysis of state-of-the-art manufacturing capability

    Science.gov (United States)

    Cavasin, Daniel

    1995-09-01

    A comprehensive process characterization was performed at the Motorola plastic package assembly site in Selangor, Malaysia, to document the current fine pitch wire bond process capability, using state-of-the-art equipment, in an actual manufacturing environment. Two machines, representing the latest technology from two separate manufacturers, were operated one shift per day for five days, bonding a 132 lead Plastic Quad Flat Pack. Using a test device specifically designed for fine pitch wire bonding, the bonding programs were alternated between 107 micrometers and 92 micrometers pad pitch, running each pitch for a total of 1600 units per machine. Wire, capillary type, and related materials were standardized and commercially available. A video metrology measurement system, with a demonstrated six sigma repeatability band width of 0.51 micrometers , was utilized to measure the bonded units for bond dimensions and placement. Standard Quality Assurance (QA) metrics were also performed. Results indicate that state-of-the-art thermosonic wire bonding can achieve acceptable assembly yields at these fine pad pitches.

  17. State-of-the-art management of low back pain in athletes: Instructional lecture.

    Science.gov (United States)

    Sairyo, Koichi; Nagamachi, Akihiro

    2016-05-01

    In this paper, we describe "state of the art" on the diagnosis and treatment for low back pain in athletes. Lumbar motion that induces specific pain would be a clue to the exact diagnosis. In the flexion pain group, lumbar herniated nucleus pulposus is the most common disorder. Discogenic pain and type 1 Modic endplate inflammation may also cause flexion pain; however, the diagnosis is sometimes difficult. In children and adolescents, apophyseal ring fracture is prevalent. In the extension pain group, lumbar spondylolysis is very common, especially in pediatric athletes. In adults, facet pain due to overloading would be the pathology, while low back pain with trunk rotation is not common. However, throwing athletes, such as pitchers and hammer throwers, may experience this kind of pain; facet arthritis contralateral to the throwing arm would be the origin of the pain. Low back pain on lumbar lateral bending is rare, but we experienced some cases in golfers in whom type 1 Modic change at the lateral corner was the source of pain. In this article, we explained strategies for state-of-the-art diagnosis and minimally invasive treatment. Copyright © 2016 The Japanese Orthopaedic Association. Published by Elsevier B.V. All rights reserved.

  18. Airway clearance techniques in neuromuscular disorders: A state of the art review.

    Science.gov (United States)

    Chatwin, Michelle; Toussaint, Michel; Gonçalves, Miguel R; Sheers, Nicole; Mellies, Uwe; Gonzales-Bermejo, Jesus; Sancho, Jesus; Fauroux, Brigitte; Andersen, Tiina; Hov, Brit; Nygren-Bonnier, Malin; Lacombe, Matthieu; Pernet, Kurt; Kampelmacher, Mike; Devaux, Christian; Kinnett, Kathy; Sheehan, Daniel; Rao, Fabrizio; Villanova, Marcello; Berlowitz, David; Morrow, Brenda M

    2018-03-01

    This is a unique state of the art review written by a group of 21 international recognized experts in the field that gathered during a meeting organized by the European Neuromuscular Centre (ENMC) in Naarden, March 2017. It systematically reports the entire evidence base for airway clearance techniques (ACTs) in both adults and children with neuromuscular disorders (NMD). We not only report randomised controlled trials, which in other systematic reviews conclude that there is a lack of evidence base to give an opinion, but also include case series and retrospective reviews of practice. For this review, we have classified ACTs as either proximal (cough augmentation) or peripheral (secretion mobilization). The review presents descriptions; standard definitions; the supporting evidence for and limitations of proximal and peripheral ACTs that are used in patients with NMD; as well as providing recommendations for objective measurements of efficacy, specifically for proximal ACTs. This state of the art review also highlights how ACTs may be adapted or modified for specific contexts (e.g. in people with bulbar insufficiency; children and infants) and recommends when and how each technique should be applied. Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.

  19. Fluidelastic vibration of cylinder arrays in axial and cross flow--state of the art

    International Nuclear Information System (INIS)

    Paidoussis, M.P.

    1981-01-01

    A critical assessment of the state of the art for flow-induced vibrations of cylinder arrays in cross and axial flow is presented. An historical review highlights the contributions which advanced understanding of the flow-induced vibration phenomena involved and/or predictive ability. In the case of axial-flow-induced vibration, the absence of separated flow regions has contributed towards the development of analytical predictive tools. The designer may predict the onset of fluidelastic instabilities, which generally occur at very high flow velocities, with greater confidence. In contrast, in the case of cross-flow-induced vibration, the complexity of the flow has encouraged more heuristic approaches to be adopted. The state of the art in this case is discussed with the aid of a new classification of the flow-induced vibration phenomena involved, to unify and clarify the contradictory claims facing the designer. It is concluded that, although the physical understanding of cross-flow-induced vibration phenomena is not good, useful design guidelines do exist. These are capable of predicting vibration characteristics to within a factor of 2 to 10. A comprehensive bibliography is included. 115 refs

  20. Thermoluminescence dosimetry: State-of-the-art and frontiers of future research

    International Nuclear Information System (INIS)

    Horowitz, Y.S.

    2014-01-01

    The state-of-the-art in the use of thermoluminescence for the measurement of energy imparted by ionizing radiation is discussed. Emphasis is on the advantages obtainable by the use of computerized glow curve analysis in (i) quality control, (ii) low dose environmental dosimetry, (iii) medical applications (especially precision) and microdosimetric applications, and (iv) mixed field ionization-density–dosimetry. Possible frontiers of future research are highlighted: (i) vector representation in glow curve analysis, (ii) combined OSL/TL measurements, (iii) detection of sub-ionization electrons, (iv) requirements for new TL materials and (v) theoretical subjects involving kinetic modeling invoking localized/delocalized recombination applied to dose response and track structure theory including creation of defects. - Highlights:: • State of the art in thermoluminescence dosimetry. • Benefits of computerized glow curve deconvolution. • Frontiers of future research:new materials, mixed-field dosimetry. • Localized/delocalized kinetic theory:ionization density dependence. • Kinetic theory:creation of defects:track structure theory

  1. Review of the state-of-the-art of exhaust particulate filter technology in internal combustion engines.

    Science.gov (United States)

    Guan, Bin; Zhan, Reggie; Lin, He; Huang, Zhen

    2015-05-01

    The increasingly stringent emission regulations, such as US 2010, Tier 2 Bin 5 and beyond, off-road Tier 4 final, and Euro V/5 for particulate matter (PM) reduction applications, will mandate the use of the diesel particulate filters (DPFs) technology, which is proven to be the only way that can effectively control the particulate emissions. This paper covers a comprehensive overview of the state-of-the-art DPF technologies, including the advanced filter substrate materials, the novel catalyst formulations, the highly sophisticated regeneration control strategies, the DPF uncontrolled regenerations and their control methodologies, the DPF soot loading prediction, and the soot sensor for the PM on-board diagnostics (OBD) legislations. Furthermore, the progress of the highly optimized hybrid approaches, which involves the integration of diesel oxidation catalyst (DOC) + (DPF, NOx reduction catalyst), the selective catalytic reduction (SCR) catalyst coated on DPF, as well as DPF in the high-pressure exhaust gas recirculation (EGR) loop systems, is well discussed. Besides, the impacts of the quality of fuel and lubricant on the DPF performance and the maintenance and retrofit of DPF are fully elaborated. Meanwhile, the high efficiency gasoline particulate filter (GPF) technology is being required to effectively reduce the PM and particulate number (PN) emissions from the gasoline direct injection (GDI) engines to comply with the future increasingly stricter emissions regulations. Copyright © 2015 Elsevier Ltd. All rights reserved.

  2. State of the Art High-Throughput Approaches to Genotoxicity: Flow Micronucleus, Ames II, GreenScreen and Comet

    Science.gov (United States)

    State of the Art High-Throughput Approaches to Genotoxicity: Flow Micronucleus, Ames II, GreenScreen and Comet (Presented by Dr. Marilyn J. Aardema, Chief Scientific Advisor, Toxicology, Dr. Leon Stankowski, et. al. (6/28/2012)

  3. Aircraft wake vortices : a state-of-the-art review of the United States R&D program

    Science.gov (United States)

    1977-02-28

    The report summarizes the current state-of-the-art understanding : of the aircraft wake vortex phenomenon and the results of the United : States program to minimize the restrictions caused by aircraft wake : vortices in the terminal environment. The ...

  4. Hybrid Imaging for Extended Depth of Field Microscopy

    Science.gov (United States)

    Zahreddine, Ramzi Nicholas

    An inverse relationship exists in optical systems between the depth of field (DOF) and the minimum resolvable feature size. This trade-off is especially detrimental in high numerical aperture microscopy systems where resolution is pushed to the diffraction limit resulting in a DOF on the order of 500 nm. Many biological structures and processes of interest span over micron scales resulting in significant blurring during imaging. This thesis explores a two-step computational imaging technique known as hybrid imaging to create extended DOF (EDF) microscopy systems with minimal sacrifice in resolution. In the first step a mask is inserted at the pupil plane of the microscope to create a focus invariant system over 10 times the traditional DOF, albeit with reduced contrast. In the second step the contrast is restored via deconvolution. Several EDF pupil masks from the literature are quantitatively compared in the context of biological microscopy. From this analysis a new mask is proposed, the incoherently partitioned pupil with binary phase modulation (IPP-BPM), that combines the most advantageous properties from the literature. Total variation regularized deconvolution models are derived for the various noise conditions and detectors commonly used in biological microscopy. State of the art algorithms for efficiently solving the deconvolution problem are analyzed for speed, accuracy, and ease of use. The IPP-BPM mask is compared with the literature and shown to have the highest signal-to-noise ratio and lowest mean square error post-processing. A prototype of the IPP-BPM mask is fabricated using a combination of 3D femtosecond glass etching and standard lithography techniques. The mask is compared against theory and demonstrated in biological imaging applications.

  5. Hybrid imaging labels

    NARCIS (Netherlands)

    Buckle, Tessa; Wal, Der Steffen Van; Malderen, Van Stijn J.M.; Müller, Larissa; Kuil, Joeri; Unen, Vincent Van; Peters, Ruud J.B.; Bemmel, van Greet; McDonnell, Liam A.; Velders, Aldrik H.; Koning, Frits; Vanhaeke, Frank; Leeuwen, Van Fijs W.B.

    2017-01-01

    Development of theranostic concepts that include inductively coupled plasma mass spectrometry (ICP-MS) and laser ablation ICP-MS (LA-ICP-MS) imaging can be hindered by the lack of a direct comparison to more standardly used methods for in vitro and in vivo evaluation; e.g. fluorescence or nuclear

  6. Proceedings of B Factories, the state of the art in accelerators, detectors and physics

    International Nuclear Information System (INIS)

    Hitlin, D.

    1992-11-01

    The conference B Factories, The State of the Art in Accelerators, Detectors and Physics was held at Stanford Linear Accelerator Center on April 6-10, 1992. The guiding principle of the conference was to bring together accelerator physicists and high energy experimentalists and theorists at the same time, with the goal of encouraging communication in defining and solving problems in a way which cut across narrow areas of specialization. Thus the conference was, in large measure, two distinct conferences, one involving accelerator specialists, the other theorists and experimentalists. There were initial and closing plenary sessions, and three separate tracks of parallel sessions, called Accelerator, Detector/Physics and Joint Interest sessions. This report contains the papers of this conference, the general topics of these cover: vacuum system, lattice design, beam-beam interactions, rf systems, feedback systems, measuring instrumentation, the interaction region, radiation background, particle detectors, particle tracking and identification, data acquisition, and computing system, and particle theory

  7. Preliminary state-of-the-art survey: mining techniques for salt and other rock types

    Energy Technology Data Exchange (ETDEWEB)

    1976-12-01

    This is a systematic review of the state-of-the-art of underground mining and excavation technology in the U.S. as applied to salt, limestone, shale, and granite. Chapter 2 covers the basic characteristics of these rock types, the most frequently used underground mining methods, shaft and slope entry construction, equipment, and safety and productivity data. Chapters 3 and 4 summarize underground salt and limestone mining in the U.S. Chapter 5 shows that large amounts of thick shale exist in the U.S., but little is mined. Chapter 6 discusses underground excavations into granite-type rocks. Suggestions are given in the last chapter for further study. (DLC)

  8. Efficient thermal desalination technologies with renewable energy systems: A state-of-the-art review

    International Nuclear Information System (INIS)

    Esfahani, Iman Janghorban; Rashidi, Jouan; Ifaei, Pouya; Yoo, ChangKyoo

    2016-01-01

    Due to the current fossil fuel crisis and associated adverse environmental impacts, renewable energy sources (RES) have drawn interest as alternatives to fossil fuels for powering water desalination systems. Over the last few decades the utility of renewable energy sources such as solar, geothermal, and wind to run desalination processes has been explored. However, the expansion of these technologies to larger scales is hampered by techno-economic and thermo-economic challenges. This paper reviews the state-of-the-art in the field of renewable energy-powered thermal desalination systems (RE-PTD) to compare their productivity and efficiency through thermodynamic, economic, and environmental analyses. We performed a comparative study using published data to classify RE-PTD systems technologies on the basis of the energy collection systems that they use. Among RE-PTD systems, solar energy powered-thermal desalination systems demonstrate high thermo-environ-economic efficiency to produce fresh water to meet various scales of demand.

  9. State of the art review of biofuels production from lignocellulose by thermophilic bacteria.

    Science.gov (United States)

    Jiang, Yujia; Xin, Fengxue; Lu, Jiasheng; Dong, Weiliang; Zhang, Wenming; Zhang, Min; Wu, Hao; Ma, Jiangfeng; Jiang, Min

    2017-12-01

    Biofuels, including ethanol and butanol, are mainly produced by mesophilic solventogenic yeasts and Clostridium species. However, these microorganisms cannot directly utilize lignocellulosic materials, which are abundant, renewable and non-compete with human demand. More recently, thermophilic bacteria show great potential for biofuels production, which could efficiently degrade lignocellulose through the cost effective consolidated bioprocessing. Especially, it could avoid contamination in the whole process owing to its relatively high fermentation temperature. However, wild types thermophiles generally produce low levels of biofuels, hindering their large scale production. This review comprehensively summarizes the state of the art development of biofuels production by reported thermophilic microorganisms, and also concludes strategies to improve biofuels production including the metabolic pathways construction, co-culturing systems and biofuels tolerance. In addition, strategies to further improve butanol production are proposed. Copyright © 2017 Elsevier Ltd. All rights reserved.

  10. Management and prevention of chronic obstructive pulmonary disease exacerbations: a state of the art review

    Directory of Open Access Journals (Sweden)

    Wedzicha Jadwiga A

    2009-08-01

    Full Text Available Abstract Exacerbations of chronic obstructive pulmonary disease (COPD are important events in the natural history of this prevalent and devastating condition. This review provides a concise, state of the art summary on prevention and management of exacerbations. Considerable new data underpins evidence in support of many preventative interventions, pharmacological and non-pharmacological, that are now available. Challenges remain in developing new approaches, and delivering those that already exist to the right patient at the right time. Management of an exacerbation remains stepwise according to clinical severity, but there is now additional focus on addressing comorbidities and taking the opportunity at acute events to optimise preventative strategies for the future. Ultimately, exacerbations are heterogeneous events in a heterogeneous disease, and an individualised approach is paramount.

  11. State of the art review of radioactive waste volume reduction techniques for commercial nuclear power plants

    International Nuclear Information System (INIS)

    1980-04-01

    A review is made of the state of the art of volume reduction techniques for low level liquid and solid radioactive wastes produced as a result of: (1) operation of commercial nuclear power plants, (2) storage of spent fuel in away-from-reactor facilities, and (3) decontamination/decommissioning of commercial nuclear power plants. The types of wastes and their chemical, physical, and radiological characteristics are identified. Methods used by industry for processing radioactive wastes are reviewed and compared to the new techniques for processing and reducing the volume of radioactive wastes. A detailed system description and report on operating experiences follow for each of the new volume reduction techniques. In addition, descriptions of volume reduction methods presently under development are provided. The Appendix records data collected during site surveys of vendor facilities and operating power plants. A Bibliography is provided for each of the various volume reduction techniques discussed in the report

  12. Pressure Sensor: State of the Art, Design, and Application for Robotic Hand

    Directory of Open Access Journals (Sweden)

    Ahmed M. Almassri

    2015-01-01

    Full Text Available We survey the state of the art in a variety of force sensors for designing and application of robotic hand. Most of the force sensors are examined based on tactile sensing. For a decade, many papers have widely discussed various sensor technologies and transducer methods which are based on microelectromechanical system (MEMS and silicon used for improving the accuracy and performance measurement of tactile sensing capabilities especially for robotic hand applications. We found that transducers and materials such as piezoresistive and polymer, respectively, are used in order to improve the sensing sensitivity for grasping mechanisms in future. This predicted growth in such applications will explode into high risk tasks which requires very precise purposes. It shows considerable potential and significant levels of research attention.

  13. Plume rise from stacks with scrubbers: a state-of-the-art review

    International Nuclear Information System (INIS)

    Schatzmann, M.; Policastro, A.J.

    1984-01-01

    The state of the art of predicting plume rise from stacks with scrubbers is evaluated critically. The significant moisture content of the scrubbed plume upon exit leads to important thermodynamic effects during plume rise that are unaccounted for in the usual dry plume rise theories. For example, under conditionally unstable atmospheres, a wet scrubbed plume treated as completely dry acts as if the atmosphere were stable, whereas in reality the scrubbed plume behaves instead as if the atmosphere were unstable. Even the use of moist plume models developed for application to cooling tower plume rise is not valid since these models 1) employ the Boussinesq approximation, 2) use a number of additional simplifying approximations that require small exit temperature differences between tower exit and ambient temperatures, and 3) are not calibrated to stack data

  14. A Webcast of Bird Nesting as a State-of-the-Art Citizen Science.

    Science.gov (United States)

    Zárybnická, Markéta; Sklenicka, Petr; Tryjanowski, Piotr

    2017-01-01

    The quality of people's knowledge of nature has always had a significant influence on their approach to wildlife and nature conservation. However, direct interactions of people with nature are greatly limited nowadays, especially because of urbanization and modern lifestyles. As a result, our isolation from the natural world has been growing. Here, we present an example of a state-of-the-art Citizen Science project with its educational, scientific, and popularizing benefits. We conclude that modern media and new forms of education offer an effective opportunity for inspiring children and others to have fun learning to act like scientists. This approach provides broad opportunities for developing the hitherto neglected educational potential of Citizen Science.

  15. The self-consistent multiparticle-multihole configuration mixing. Motivations, state of the art and perspectives

    Energy Technology Data Exchange (ETDEWEB)

    Pillet, N.; Dupuis, M.; Hupin, G.; Berger, J.F. [DAM, CEA, Arpajon (France); Robin, C. [Western Michigan University, Department of Physics, Kalamazoo, MI (United States)

    2017-03-15

    The main objective of this paper is to review the state of the art of the multiparticle-multihole configuration mixing approach which was proposed and implemented using the Gogny interaction ∝ 10 years ago. Various theoretical aspects are re-analyzed when a Hamiltonian description is chosen: the link with exact many-body theories, the impact of truncations in the multiconfigurational space, the importance of defining single-particle orbitals which are consistent with the correlations introduced in the many-body wave function, the role of the self-consistency, and more practically the numerical convergence algorithm. Several applications done with the phenomenological effective Gogny interaction are discussed. Finally, future directions to extend and generalize the method are discussed. (orig.)

  16. The SESAME project. State of the art liquid metal thermal hydraulics and beyond

    Energy Technology Data Exchange (ETDEWEB)

    Roelofs, F.; Shams, A.; Batta, A.; Moreau, V.; Di Piazza, I.; Gerschenfeld, A.; Planquart, P.; Tarantino, M. [Nuclear Research and Consultancy Group (NRG), Petten (Netherlands)

    2017-08-15

    The European Sustainable Nuclear Industry Initiative (ESNII) aims at industrial application of fast reactor technology for a sustainable nuclear energy production. Currently four demonstration projects have a promising outlook in Europe, i.e. the ASTRID project in France, the MYRRHA project in Belgium, the ALFRED pan-European project to be realized in Romania, and SEALER in Sweden. Sodium and lead(-alloys) are envisaged as coolants for these reactors. Obviously, in the development of these reactors, thermal-hydraulics is recognized as a key challenge with emphasis on safety issues. This paper discusses the state-of-the-art knowledge with respect to experiments and simulation techniques as pursued in the Horizon 2020 SESAME (thermal hydraulics Simulations and Experiments for the Safety Assessment of MEtal cooled reactors) project.

  17. Electrostatic Discharge (ESD and Electrical Overstress (EOS: The state of the art in components to systems

    Directory of Open Access Journals (Sweden)

    Steven H. Voldman

    2017-06-01

    Full Text Available Electrostatic Discharge (ESD, Electrical Overstress (EOS and electromagnetic compatibility (EMC continue to impact semiconductor manufacturing, semiconductor components and systems as technologies scale from micro- to nano-electronics. The range of concern for components include semiconductor components, magnetic recording industry, MEMs, and for products from disk drives, cell phones, notebooks, tablets, laptops, and desktop computers. The objective of this lecture is to address the state of the art of electrostatic discharge (ESD and electrical overstress (EOS in today’s electronic components and systems. The tutorial provides a clear picture of ESD, EOS and EMC phenomena, sources, physics, failure mechanisms, testing and qualification of components and systems. The conclusion of this talk is that ESD and EOS continue to be a concern in technologies from micro-electronics to nano-structures, and will remain a reliability and quality issue in the future.

  18. State of the art on cyanotoxins in water and their behaviour towards chlorine.

    Science.gov (United States)

    Merel, Sylvain; Clément, Michel; Thomas, Olivier

    2010-04-01

    The occurrence of cyanobacterial blooms is drastically increasing in temperate countries and drinking water resources are threatened. As a result, cyanotoxins should be considered in water treatment to protect human health. This study presents a state of the art on cyanotoxins in water and their behaviour towards chlorination, a common drinking water disinfection process. Chlorination efficiency on cyanotoxins alteration depends on pH, chlorine dose and oxidant nature. Microcystins and cylindrospermopsin are efficiently transformed by chlorine, with respectively 6 and 2 by-products identified. In addition, chlorination of microcystins and cylindrospermopsin is associated with a loss of acute toxicity. Even though they have been less investigated, saxitoxins and nodularins are also altered by chlorine. For these toxins, no by-products have been identified, but the chlorinated mixture does not show acute toxicity. On the contrary, the fact that anatoxin-a has a very slow reaction kinetics suggests that this toxin resists chlorination. Copyright 2009 Elsevier Ltd. All rights reserved.

  19. State-of-the-art and research needs for oil spill impact assessment modelling

    International Nuclear Information System (INIS)

    French-McCay, D.

    2009-01-01

    Many oil spill models focus on trajectory and fate in aquatic environments. Models designed to address subsurface oil concentrations typically overlay fates model concentration results on maps or grids of biological distributions to assess impacts. This paper discussed a state-of-the-art biological effects model designed to evaluate the impacts and dose of oil spill hydrocarbons on aquatic biota including birds, mammals, reptiles, fish, invertebrates and plants. The biological effects model was coupled to an oil trajectory and fates spill impact model application package (SIMAP) in order to obtain accurate spatial and temporal quantifications of oil distributions and hydrocarbon component concentrations. Processes simulated in the model included slick spreading, evaporation of volatiles from surface oil, transport on the water surface, and various types of oil dispersion and emulsification. The design of the model was discussed, as well as strategies used for applying the model for hindcasts and risk assessments. 204 refs., 3 tabs., 5 figs

  20. Advanced robotics for medical rehabilitation current state of the art and recent advances

    CERN Document Server

    Xie, Shane

    2016-01-01

    Focussing on the key technologies in developing robots for a wide range of medical rehabilitation activities – which will include robotics basics, modelling and control, biomechanics modelling, rehabilitation strategies, robot assistance, clinical setup/implementation as well as neural and muscular interfaces for rehabilitation robot control – this book is split into two parts; a review of the current state of the art, and recent advances in robotics for medical rehabilitation. Both parts will include five sections for the five key areas in rehabilitation robotics: (i) the upper limb; (ii) lower limb for gait rehabilitation (iii) hand, finger and wrist; (iv) ankle for strains and sprains; and (v) the use of EEG and EMG to create interfaces between the neurological and muscular functions of the patients and the rehabilitation robots. Each chapter provides a description of the design of the device, the control system used, and the implementation and testing to show how it fulfils the needs of that specific ...

  1. State of the Art Power-in Tube Niobium-Tin Superconductors

    Energy Technology Data Exchange (ETDEWEB)

    Godeke, A.; Ouden, A. Den; Nijhuis, A.; ten Kate, H.H.J.

    2008-06-01

    Powder-in-Tube (PIT) processed Niobium-Tin wires are commercially manufactured for nearly three decades and have demonstrated a combination of very high current density (presently up to 2500 A mm{sup -2} non-Cu at 12 T and 4.2 K) with fine (35 {micro}m), well separated filaments. We review the developments that have led to the present state of the art PIT Niobium-Tin wires, discuss the wire manufacturing and A15 formation processes, and describe typical superconducting performance in relation to magnetic field and strain. We further highlight successful applications of PIT wires and conclude with an outlook on possibilities for further improvements in the performance of PIT Niobium-Tin wires.

  2. Ionic Liquids Beyond Simple Solvents: Glimpses at the State of the Art in Organic Chemistry.

    Science.gov (United States)

    Kuchenbuch, Andrea; Giernoth, Ralf

    2015-12-01

    Within the last 25 years ionic liquids have written a tremendous success story, which is documented in a nearly uncountable amount of original research papers, reviews, and numerous applications in research and industry. These days, ionic liquids can be considered as a mature class of compounds for many different applications. Frequently, they are used as neoteric solvents for chemical tansformations, and the number of reviews on this field of research is huge. In this focused review, though, we are trying to evaluate the state of the art of ionic liquid chemistry beyond using them simply as solvents for chemical transformations. It is not meant to be a comprehensive overview on the topic; the choice of emphasis and examples rather refects the authors' personal view on the field. We are especially highlighting fields in which we believe the most fundamental developments within the next five years will take place: biomass processing, (chiral) ionic liquids from natural sources, biotransformations, and organic synthesis.

  3. Asset Management The State of the Art in Europe from a Life Cycle Perspective

    CERN Document Server

    Herder, Paulien; Wijnia, Ype

    2012-01-01

    In the past decades asset intensive companies have witnessed a number of regulatory changes and especially industry is facing ever increasing competitiveness. To overcome these challenges different asset management methods have been developed aimed to improve the asset life cycle. Especially the design phase and operation and maintenance phase have seen a rise in tools and methods. Smarter design can lead to improved operation. Likewise, improved operation and maintenance leads to lower replacement costs and may provide the basis for better design.   This book brings together and coherently presents the current state of the art in asset management research and practice in Europe from a life cycle perspective. Each chapter  focuses on specific parts of this life cycle and explains how the methods and techniques described are connected and how they improve the asset life cycle, thus treating this important subject from a unique perspective.

  4. State of the art on defenses against wormhole attacks in wireless sensor networks

    DEFF Research Database (Denmark)

    Prasad, Neeli R.; Giannetsos, T.; Dimitriou, T.

    2009-01-01

    describe the wormhole attack, a severe routing attack against sensor networks that is particularly challenging to defend against. We detail its characteristics and study its effects on the successful operation of a sensor network. We present state-of-the-art research for addressing wormhole related...... the possibility of using more sophisticated methods, like intrusion detection systems, to achieve a more complete and autonomic defense mechanism against wormhole attackers. We present our work on intrusion detection and introduce a lightweight IDS framework, called LIDeA, designed for wireless sensor networks....... LIDeA is based on a distributed architecture, in which nodes overhear their neighboring nodes and collaborate with each other in order to successfully detect an intrusion. We conclude by highlighting how such a system can be used for defending against wormhole attackers....

  5. A state-of-the-art plasma polymerization coater for ICF targets

    International Nuclear Information System (INIS)

    Devine, G.; Letts, S.; Cook, R.; Brusasco, R.

    1992-01-01

    Increasingly stringent demands on the characteristics of plasma polymer coatings for use in Inertial Confinement Fusion (ICF) experiments have created a need for a plasma Polymerization coating system with the capability of producing a wide variety of different types of coatings as well as one that can be used to do fundamental investigations of the process conditions leading to desirable films. We report on the construction and use of just such a coating instrument. We have recognized the usefulness of computer assisted process monitoring and control, currently being developed by the semiconductor industry, in designing our own, State-of-the-art plasma polymerization device. Our system is fully computer interfaced to provide the user with the capability of collecting system parameter data over the length of the deposition experiment. The system is also designed to allow for any degree of computer control of the deposition process in the future

  6. Efficient thermal desalination technologies with renewable energy systems: A state-of-the-art review

    Energy Technology Data Exchange (ETDEWEB)

    Esfahani, Iman Janghorban; Rashidi, Jouan; Ifaei, Pouya; Yoo, ChangKyoo [Center for Environmental Studies, Kyung Hee University, Yongin (Korea, Republic of)

    2016-02-15

    Due to the current fossil fuel crisis and associated adverse environmental impacts, renewable energy sources (RES) have drawn interest as alternatives to fossil fuels for powering water desalination systems. Over the last few decades the utility of renewable energy sources such as solar, geothermal, and wind to run desalination processes has been explored. However, the expansion of these technologies to larger scales is hampered by techno-economic and thermo-economic challenges. This paper reviews the state-of-the-art in the field of renewable energy-powered thermal desalination systems (RE-PTD) to compare their productivity and efficiency through thermodynamic, economic, and environmental analyses. We performed a comparative study using published data to classify RE-PTD systems technologies on the basis of the energy collection systems that they use. Among RE-PTD systems, solar energy powered-thermal desalination systems demonstrate high thermo-environ-economic efficiency to produce fresh water to meet various scales of demand.

  7. Evaluation of State-of-the-Art Acoustic Feedback Cancellation Systems for Hearing Aids

    DEFF Research Database (Denmark)

    Guo, Meng; Jensen, Søren Holdt; Jensen, Jesper

    2013-01-01

    This research evaluates four state-of-the-art acoustic feedback cancellation systems in hearing aids in terms of the cancellation performance, sound quality degradation, and computational complexity. The authors compared a traditional full-band system to a system with a prediction error method...... in a full band, a subband system, a subband system with frequency shifting, and a recently proposed subband system with a novel probe noise deployment. All systems outperformed the traditional full-band system in cancellation performance, especially the subband system with probe noise is most effective...... for cancellation. However, in all cases there was a trade-off between performance and computational cost. With a 3-times increase in computation load, the probe noise based cancellation system can be realized that functions even in the most challenging feedback situation....

  8. Wastewater treatment modelling in practice: a collaborative discussion of the state of the art.

    Science.gov (United States)

    Phillips, H M; Sahlstedt, K E; Frank, K; Bratby, J; Brennan, W; Rogowski, S; Pier, D; Anderson, W; Mulas, M; Copp, J B; Shirodkar, N

    2009-01-01

    Three consulting teams conducted independent modelling projects for three different wastewater treatment plants ranging in size from approximately 113,800 m(3)/d (30 mgd) to 530,000 m(3)/d (140 mgd), in different parts of the world (USA and Finland). The plants have different treatment objectives ranging from nitrification and partial denitrification (nitrate plus nitrite BioWin), and a variation of the Dold model methanol degradation capabilities (NGmeth within GPS-X). The authors compare and contrast the modelling approaches taken, including calibration and validation approaches, sensitivity analyses, and the application of results to full-scale studies, designs and operations. Despite several differences between the approaches, there are many similarities which are discussed in light of the IWA draft uniform protocol for activated sludge modelling. The authors also discuss current modelling limitations and offer suggestions to improve the state of the art.

  9. Deep Learning for Brain MRI Segmentation: State of the Art and Future Directions.

    Science.gov (United States)

    Akkus, Zeynettin; Galimzianova, Alfiia; Hoogi, Assaf; Rubin, Daniel L; Erickson, Bradley J

    2017-08-01

    Quantitative analysis of brain MRI is routine for many neurological diseases and conditions and relies on accurate segmentation of structures of interest. Deep learning-based segmentation approaches for brain MRI are gaining interest due to their self-learning and generalization ability over large amounts of data. As the deep learning architectures are becoming more mature, they gradually outperform previous state-of-the-art classical machine learning algorithms. This review aims to provide an overview of current deep learning-based segmentation approaches for quantitative brain MRI. First we review the current deep learning architectures used for segmentation of anatomical brain structures and brain lesions. Next, the performance, speed, and properties of deep learning approaches are summarized and discussed. Finally, we provide a critical assessment of the current state and identify likely future developments and trends.

  10. The State of the Art of the Borehole Disposal Concept for High Level Radioactive Waste

    International Nuclear Information System (INIS)

    Ji, Sung Hoon; Koh, Yong Kwon; Choi, Jong Won

    2012-01-01

    As an alternative of the high-level radioactive waste disposal in the subsurface repository, a deep borehole disposal is reviewed by several nuclear advanced countries. In this study, the state of the art on the borehole disposal researches was reviewed, and the possibility of borehole disposal in Korean peninsula was discussed. In the deep borehole disposal concept radioactive waste is disposed at the section of 3 - 5 km depth in a deep borehole, and it has known that it has advantages in performance and cost due to the layered structure of deep groundwater and small surface disposal facility. The results show that it is necessary to acquisite data on deep geologic conditions of Korean peninsula, and to research the engineering barrier system, numerical modeling tools and disposal techniques for deep borehole disposal.

  11. Multilingual Sentiment Analysis: State of the Art and Independent Comparison of Techniques.

    Science.gov (United States)

    Dashtipour, Kia; Poria, Soujanya; Hussain, Amir; Cambria, Erik; Hawalah, Ahmad Y A; Gelbukh, Alexander; Zhou, Qiang

    With the advent of Internet, people actively express their opinions about products, services, events, political parties, etc., in social media, blogs, and website comments. The amount of research work on sentiment analysis is growing explosively. However, the majority of research efforts are devoted to English-language data, while a great share of information is available in other languages. We present a state-of-the-art review on multilingual sentiment analysis. More importantly, we compare our own implementation of existing approaches on common data. Precision observed in our experiments is typically lower than the one reported by the original authors, which we attribute to the lack of detail in the original presentation of those approaches. Thus, we compare the existing works by what they really offer to the reader, including whether they allow for accurate implementation and for reliable reproduction of the reported results.

  12. State-of-the-art review of sodium fire analysis and current notions for improvements

    International Nuclear Information System (INIS)

    Tasi, S.S.

    1978-01-01

    Sodium releases from postulated pipe ruptures, as well as failures of sodium handling equipment in liquid metal fast breeder reactors, may lead to substantial pressure-temperature transients in the sodium system cells, as well as in the reactor containment building. Sodium fire analyses are currently performed with analytical tools, such as the SPRAY, SOMIX, SPOOL-FIRE and SOFIRE-II codes. A review and evaluation of the state-of-the-art in sodium fire analysis is presented, and suggestions for further improvements are made. This work is based, in part, on studies made at Brookhaven National Laboratory during the past several years in the areas of model development and improvement associated with the accident analyses of LMFBRs

  13. Additive manufacturing of titanium alloys state of the art, challenges and opportunities

    CERN Document Server

    Dutta, Bhaskar

    2016-01-01

    Additive Manufacturing of Titanium Alloys: State of the Art, Challenges and Opportunities provides alternative methods to the conventional approach for the fabrication of the majority of titanium components produced via the cast and wrought technique, a process which involves a considerable amount of expensive machining. In contrast, the Additive Manufacturing (AM) approach allows very close to final part configuration to be directly fabricated minimizing machining cost, while achieving mechanical properties at least at cast and wrought levels. In addition, the book offers the benefit of significant savings through better material utilization for parts with high buy-to-fly ratios (ratio of initial stock mass to final part mass before and after manufacturing). As titanium additive manufacturing has attracted considerable attention from both academicians and technologists, and has already led to many applications in aerospace and terrestrial systems, as well as in the medical industry, this book explores the un...

  14. Fatigue of Nitinol: The state-of-the-art and ongoing challenges.

    Science.gov (United States)

    Mahtabi, M J; Shamsaei, Nima; Mitchell, M R

    2015-10-01

    Nitinol, a nearly equiatomic alloy of nickel and titanium, has been considered for a wide range of applications including medical and dental devices and implants as well as aerospace and automotive components and structures. The realistic loading condition in many of these applications is cyclic; therefore, fatigue is often the main failure mode for such components and structures. The fatigue behavior of Nitinol involves many more complexities compared with traditional metal alloys arising from its uniqueness in material properties such as superelasticity and shape memory effects. In this paper, a review of the present state-of-the-art on the fatigue behavior of superelastic Nitinol is presented. Various aspects of fatigue of Nitinol are discussed and microstructural effects are explained. Effects of material preparation and testing conditions are also reviewed. Finally, several conclusions are made and recommendations for future works are offered. Copyright © 2015 Elsevier Ltd. All rights reserved.

  15. Solar heating systems: state-of-the-art and prospects for the future

    International Nuclear Information System (INIS)

    Frei, U.

    2001-01-01

    This article discusses the development of the use of solar collectors over their past 30 years of history and describes today's state-of-the-art for solar installations that are used for hot water preparation and space heating. Advances made in storage technology, in the dimensioning of installations and in the operation of the systems are discussed in detail. The importance of low-flow operation for hot water installations is emphasised. Also, the integration of solar and conventional heating systems is looked at and questions regarding further factors such as those encountered in low-energy-consumption buildings are discussed. Future developments in the product and market areas are looked at, including new forms of storage as well as solar cooling and air-conditioning

  16. The History of Liquid Ear Acupuncture and the Current Scientific State of the Art

    Directory of Open Access Journals (Sweden)

    Daniela Litscher

    2016-06-01

    Full Text Available This short review article presents a current overview of existing publications and scientific results regarding liquid (ear acupuncture. The injection of liquids into defined acupuncture points of the ear is not a method commonly used in the Western world. The term liquid acupuncture has different definitions, which makes understanding each definition and differentiating one from the other difficult. General terms like pharmacopuncture, homeosiniatry, and liquid acupuncture, which all describe the method of injecting different kinds of drugs into a defined body acupuncture point, are used. This article presents the history of liquid acupuncture, as well as the current scientific state of the art, from the point of view of two European researchers. Some articles are discussed and a few practical examples are presented.

  17. Endovascular Interventions for Acute and Chronic Lower Extremity Deep Venous Disease: State of the Art

    Science.gov (United States)

    Sista, Akhilesh K.; Vedantham, Suresh; Kaufman, John A.

    2015-01-01

    The societal and individual burden caused by acute and chronic lower extremity venous disease is considerable. In the past several decades, minimally invasive endovascular interventions have been developed to reduce thrombus burden in the setting of acute deep venous thrombosis to prevent both short- and long-term morbidity and to recanalize chronically occluded or stenosed postthrombotic or nonthrombotic veins in symptomatic patients. This state-of-the-art review provides an overview of the techniques and challenges, rationale, patient selection criteria, complications, postinterventional care, and outcomes data for endovascular intervention in the setting of acute and chronic lower extremity deep venous disease. Online supplemental material is available for this article. © RSNA, 2015 PMID:26101920

  18. Giant magnetoresistance (GMR) sensors from basis to state-of-the-art applications

    CERN Document Server

    Reig, Candid; Mukhopadhyay, Subhas Chandra

    2013-01-01

    Since the discovery of the giant magnetoresistance (GMR) effect in 1988, spintronics has been presented as a new technology paradigm, awarded by the Nobel Prize in Physics in 2007. Initially used in read heads of hard disk drives, and while disputing a piece of the market to the flash memories, GMR devices have broadened their range of usage by growing towards magnetic field sensing applications in a huge range of scenarios. Potential applications at the time of the discovery have become real in the last two decades. Definitively, GMR was born to stand. In this sense, selected successful approaches of GMR based sensors in different applications: space, automotive, microelectronics, biotechnology … are collected in the present book. While keeping a practical orientation, the fundamentals as well as the current trends and challenges of this technology are also analyzed. In this sense, state of the art contributions from academy and industry can be found through the contents. This book can be used by starting ...

  19. The separation and recycling of actinides: a review of the state of the art

    International Nuclear Information System (INIS)

    McKay, H.A.C.; Sowerby, M.G.; Bustraan, M.; Montizaan, J.; Dalen, A. van; Verkerk, B.

    1977-01-01

    The principal objective of this study is to assess the state of the art of separating the actinides and recycling them to reactors. To this end, the literature has been surveyed, discussions have been held at the contractors' laboratories, AERE, Harwell, UK and ECN, Petten, Netherlands, and visits have been paid to the establishments where relevant work is in progress. The study does not include any new experimental work, but a certain amount of computation has been carried out to support it. A programme of installation of reactors within the European Communities was supplied for the purposes of this study. The prospective generating facilities in GW(e) are given. The situation in the various areas of investigation involved is as follows: nuclear physics: favourable; chemical separations: difficult, but probably feasible; nuclear incineration strategies: little studied so far; fuel and fuel elements containing recycled actinides: little development so far

  20. Trends in Mobile Computing: State-of-the-Art and Next Steps

    CERN Document Server

    CERN. Geneva

    2006-01-01

    Computing is moving to the edge of the network. It is becoming increasingly personal and allowing people to enjoy and express themselves in unprecedented ways. The same development allows professionals and enterprises to increase quality and productivity through improved mobility. The seminar discusses the underlying technical and societal trends and the state-of-the-art of mobile computing. Examples of current developments include the transformation of mobile devices into servers, augmented reality in mobile devices and the opportunities offered by wireless sensor networks. The fusion of the physical and digital worlds enabled by mobile computing is driving industry and society to adopt new uses of digital technologies and causing the focus of development to shift from hardware products to new services. Bio:Since 2004 Prof. Jan Bosch is working as Vice President and Head of the Software and Application Technology Laboratory of Nokia Research Centre in Helsinki, Finland. The Software & Application Tec...

  1. State-of-the-art review of some artificial intelligence applications in pile foundations

    Directory of Open Access Journals (Sweden)

    Mohamed A. Shahin

    2016-01-01

    Full Text Available Geotechnical engineering deals with materials (e.g. soil and rock that, by their very nature, exhibit varied and uncertain behavior due to the imprecise physical processes associated with the formation of these materials. Modeling the behavior of such materials in geotechnical engineering applications is complex and sometimes beyond the ability of most traditional forms of physically-based engineering methods. Artificial intelligence (AI is becoming more popular and particularly amenable to modeling the complex behavior of most geotechnical engineering applications because it has demonstrated superior predictive ability compared to traditional methods. This paper provides state-of-the-art review of some selected AI techniques and their applications in pile foundations, and presents the salient features associated with the modeling development of these AI techniques. The paper also discusses the strength and limitations of the selected AI techniques compared to other available modeling approaches.

  2. A project based learning experience through best use of state-of-the-art technology

    Directory of Open Access Journals (Sweden)

    Juan José López Berrio

    2016-01-01

    Full Text Available Our proposal consists in activating the most important talent in the education institutions (their students, converting them in the change movement they need. How do we do that? We attract them through an enriching and disruptive programme, that suggest them a real entrepreneurship challenge, guiding and empowering them to reach the goals planned. Our vehicle is the Innovation Lab, a permanent program, where through a project based learning and working as a real and modern startup, the students work and collaborate using state of the art technology and methodologies, such as cloud computing, design thinking, flipped classroom, gamification, etc., by combining on-line work and sessions at school. The idea is revolutionary and innovative but also perfectly aligned with the content of the Horizon 2020-Schools Edition. We have achieved great results, both qualitative and quantitative, as you would be able to see along the article.

  3. State-of-the-art and research needs for oil spill impact assessment modelling

    Energy Technology Data Exchange (ETDEWEB)

    French-McCay, D. [Applied Science Associates Inc., South Kingstown, RI (United States)

    2009-07-01

    Many oil spill models focus on trajectory and fate in aquatic environments. Models designed to address subsurface oil concentrations typically overlay fates model concentration results on maps or grids of biological distributions to assess impacts. This paper discussed a state-of-the-art biological effects model designed to evaluate the impacts and dose of oil spill hydrocarbons on aquatic biota including birds, mammals, reptiles, fish, invertebrates and plants. The biological effects model was coupled to an oil trajectory and fates spill impact model application package (SIMAP) in order to obtain accurate spatial and temporal quantifications of oil distributions and hydrocarbon component concentrations. Processes simulated in the model included slick spreading, evaporation of volatiles from surface oil, transport on the water surface, and various types of oil dispersion and emulsification. The design of the model was discussed, as well as strategies used for applying the model for hindcasts and risk assessments. 204 refs., 3 tabs., 5 figs.

  4. Global Software Development: A Review of the State-Of-The-Art (2007-2011)

    DEFF Research Database (Denmark)

    Ali Babar, Muhammad; Zahedi, Mansooreh

    a state-of-the-art review of the GSD research literature published in the main venue of Global Software Engineering in order to identify the main research trends and gaps that needs to be filled by future research. We were also interested placing the findings of our review with respect to a practice......-driven GSD research agenda. Method: We used structured literature review methodology for which we decided to select and review the recently published research papers (i.e., 2007 - 2011) from the International Conference in Global Software Engineering (ICGSE). We used a framework for organizing GSD research...... challenges and threats and a practice-driven research agenda for extracting and organizing the data from the reviewed papers. We used theoretical reasoning for classifying the reviewed papers under different categories, which were mainly based on the framework, a decision that also enabled us to propose...

  5. The new science of moral cognition: the state of the art

    Directory of Open Access Journals (Sweden)

    Antonio Olivera La Rosa

    2014-10-01

    Full Text Available The need for multidisciplinary approaches to the scientific study of human nature is a widely supported academic claim. This assumption has proved to be especially successful in the field of moral psychology. Although studies of moral topics have been ubiquitous in both humanities and social sciences, it is not until the integration of different scientific disciplines in the convergent science of moral psychology that the study of morality seems to start its flourishing age. Thus, in the last ten years, a growing body of research from cognitive sciences, experimental philosophy, primatology, clinical and developmental psychology, economy and anthropology have made possible a "new era" on the study of morality. In this paper, we review the most striking findings that constitute the "state of the art' of moral psychology, with the aim to facilitate a better understanding of how the mind functions in the moral domain.

  6. State-of-the-art review of some artificial intelligence applications in pile foundations

    Institute of Scientific and Technical Information of China (English)

    Mohamed A. Shahin

    2016-01-01

    Geotechnical engineering deals with materials (e.g. soil and rock) that, by their very nature, exhibit varied and uncertain behavior due to the imprecise physical processes associated with the formation of these materials. Modeling the behavior of such materials in geotechnical engineering applications is complex and sometimes beyond the ability of most traditional forms of physically-based engineering methods. Artificial intelligence (AI) is becoming more popular and particularly amenable to modeling the complex behavior of most geotechnical engineering applications because it has demonstrated superior predictive ability compared to traditional methods. This paper provides state-of-the-art review of some selected AI techniques and their applications in pile foundations, and presents the salient features associated with the modeling development of these AI techniques. The paper also discusses the strength and limitations of the selected AI techniques compared to other available modeling approaches.

  7. [Hyperbaric oxygen treatment of musculoskeletal disorders on the sports medicine. State of the art].

    Science.gov (United States)

    Drobnic, Franchek; Turmo, Antonio

    2010-03-13

    Hyperbaric oxygen therapy (OHB) is a therapeutic modality based on the properties of partial pressure of oxygen, when breathing pure oxygen under hyperbaric conditions in a chamber designed for that purpose. Its indications in medicine are considered as primary, complementary or experimental depending on the evidence based effects. From different sectors of medicine, OHB has been recently proposed as a new tool for other pathologies, primarily in musculoskeletal disorders. In this paper, the state of the art of the influence from experimental studies is reviewed. Some considerations based on these studies are hypothesized as the minimum required to obtain good results when this therapy is decided to be used as co adjuvant to standard treatment. Copyright 2009 Elsevier España, S.L. All rights reserved.

  8. A state-of-the art on decommissioning of nuclear facilities in Japan

    International Nuclear Information System (INIS)

    Park, Seung Kook; Kim, Hee Reyoung; Chung, Un Soo; Jung, Ki Jung

    2002-05-01

    While proceeding the KRR-1 and 2 decommissioning project, we are carried out study for the state of the art on decommissioning of nuclear facilities in Japan. Also, we are studied for the research reactors and commercial power plant that has the object of decommissioning, and for the government and the organization related on decommissioning operation. We are investigated for decommissioning activities of nuclear facilities achieved by JAERI, and collected the information and data for decommissioning techniques and computational system through the JPDR(Japan Power Demonstration Reactor) decommissioning activities. Such techniques are applying for Tokai Power Station began the decommissioning project from last year, and for Fugen Nuclear Power Station to be planned the decommissioning from 2003. Recent techniques for decommissioning was acquired by direct contact. The status of the treatment for decommissioning waste and the disposal facility for the very low-level radioactive concrete wastes was grasped

  9. Base technology development enhances state-of-the-art in meeting performance requirements

    International Nuclear Information System (INIS)

    Freedman, J.M.; Allen, G.C. Jr.; Luna, R.E.

    1987-01-01

    Sandia National Laboratories (SNL) has responsibility to the United States Department of Energy (DOE) for baseline technology to support the design of radioactive material transportation packages. To fulfill this responsibility, SNL works with industry, government agencies, and national laboratories to identify and develop state-of-the-art technology required to design and test safe, cost-effective radioactive materials packages. Principal elements of the base technology program include: 1) analysis techniques, 2) testing, 3) subsystem and component development, 4) packaging systems development support, and 5) technical support for policy development. These program elements support a systems approach for meeting performance requirements and assure that there is a sound underlying technical basis for both transportation packaging design and associated policy decisions. Highlights from the base technology program included in this paper are testing, design and analysis methods, advanced materials, risk assessment and logistics models, and transportation package support

  10. Text mining for adverse drug events: the promise, challenges, and state of the art.

    Science.gov (United States)

    Harpaz, Rave; Callahan, Alison; Tamang, Suzanne; Low, Yen; Odgers, David; Finlayson, Sam; Jung, Kenneth; LePendu, Paea; Shah, Nigam H

    2014-10-01

    Text mining is the computational process of extracting meaningful information from large amounts of unstructured text. It is emerging as a tool to leverage underutilized data sources that can improve pharmacovigilance, including the objective of adverse drug event (ADE) detection and assessment. This article provides an overview of recent advances in pharmacovigilance driven by the application of text mining, and discusses several data sources-such as biomedical literature, clinical narratives, product labeling, social media, and Web search logs-that are amenable to text mining for pharmacovigilance. Given the state of the art, it appears text mining can be applied to extract useful ADE-related information from multiple textual sources. Nonetheless, further research is required to address remaining technical challenges associated with the text mining methodologies, and to conclusively determine the relative contribution of each textual source to improving pharmacovigilance.

  11. Wind turbines and seismic hazard: a state-of-the-art review

    DEFF Research Database (Denmark)

    Katsanos, Evangelos; Thöns, Sebastian; Georgakis, Christos T.

    2016-01-01

    , India, Southern Europe and East Asia) highlight the necessity for thorough consideration of the seismic implications on these energy harnessing systems. Along these lines, this state-of-the-art paper presents a comparative survey of the published research relevant to the seismic analysis, design......Wind energy is a rapidly growing field of renewable energy, and as such, intensive scientific and societal interest has been already attracted. Research on wind turbine structures has been mostly focused on the structural analysis, design and/or assessment of wind turbines mainly against normal...... and assessment of wind turbines. Based on numerical simulation, either deterministic or probabilistic approaches are reviewed, because they have been adopted to investigate the sensitivity of wind turbines’ structural capacity and reliability in earthquake-induced loading. The relevance of seismic hazard...

  12. SAR interferometry applications on active volcanoes. State of the art and perspectives for volcano monitoring

    Energy Technology Data Exchange (ETDEWEB)

    Puglisi, G.; Coltelli, M. [Istituto Nazionale di Geofisica e Vulcanologia, Catania (Italy)

    2001-02-01

    In this paper the application of the Synthetic Aperture Radar Interferometry (INSAR) on volcanology is analysed. Since it is not a real novelty among the different applications of INSAR in Earth Observation activities, at the beginning of this paper it is analysed the state of the art of the researches in this field. During the discussion, the point of view of volcanologists is favoured because it is considered that the first applications were often badly aimed. Consequently, the initial INSAR performances in volcanology were overrated with respect to the real capabilities of this technique. This fact lead to discover some unexpected limitations in INSAR usage in volcano monitoring, but, at the same time, spurred on scientists to overcome these drawbacks. The results achieved recently allow to better apply SAR to volcanology; in the paper a possible operative work-plan aimed at introducing INSAR in the volcano monitoring system is presented.

  13. Remote and continuous gamma spectrometry for environmental radiation protection: state of the art technology and perspectives

    International Nuclear Information System (INIS)

    Van Put, Ph.; Lellis, C.; Debauche, A.; Lacroix, J-P.

    2004-01-01

    The instruments technologies for radiological protection of the environment have been considerably enhanced since the last 20 years. From very simple warning bells in the early 80s, the instruments have been sophisticated nowadays to a degree where their performances can be compared to the performances achieved in low level laboratories. This presentation will briefly overview the evolution of these instruments by comparing their technology, their methodology and their performances. Next, it will present the concepts of the state of the art technology in the field of continuous monitoring of the environment. A discussion will follow on the performances and the limitations of this technology. Finally, the presentation will highlight the future perspective of developments by taking into account recent progress in the field of radiation detectors, telecommunication and computer sciences among others. (authors)

  14. Ionic liquids in protein amyloidogenesis: a brief screenshot of the state-of-the-art.

    Science.gov (United States)

    Pillai, Visakh V S; Benedetto, Antonio

    2018-05-03

    Ionic liquids (ILs) are a vast class of organic non-aqueous electrolytes whose interaction with biomolecules is receiving great attention for potential applications in bio-nano-technology. Recently, it has been shown that ILs can affect protein amyloidogenesis. Whereas some ILs favour the aggregation of proteins into amyloids, others inhibit their formation. Moreover, ILs can dissolve mature fibrils and restore the protein biochemical function. In this letter, we present a brief state-of-the-art summary of this emerging field that holds the promise of important developments both in basic science and in applications from bio-medicine to material science, and bio-nano-technology. The huge variety of ILs offers a vast playground for future studies and potential applications.

  15. Ex vivo lung perfusion in clinical lung transplantation--state of the art.

    Science.gov (United States)

    Andreasson, Anders S I; Dark, John H; Fisher, Andrew J

    2014-11-01

    Ex vivo lung perfusion (EVLP) has emerged as a new technique for assessing and potentially reconditioning human donor lungs previously unacceptable for clinical transplantation with the potential to dramatically push the limits of organ acceptability. With the recent introduction of portable EVLP, a new era in lung preservation may be upon us with the opportunity to also limit organ ischaemic times and potentially improve the outcome of donor lungs already deemed acceptable for transplantation. It took over half a century for the technique to evolve from basic theory to semi-automated circuits fit for clinical use that are now rapidly being adopted in transplant centres across the globe. With this field in constant evolution and many unanswered questions remaining, our review serves as an update on the state of the art of EVLP in clinical lung transplantation. © The Author 2014. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.

  16. Aeroelastic Tailoring of Transport Aircraft Wings: State-of-the-Art and Potential Enabling Technologies

    Science.gov (United States)

    Jutte, Christine; Stanford, Bret K.

    2014-01-01

    This paper provides a brief overview of the state-of-the-art for aeroelastic tailoring of subsonic transport aircraft and offers additional resources on related research efforts. Emphasis is placed on aircraft having straight or aft swept wings. The literature covers computational synthesis tools developed for aeroelastic tailoring and numerous design studies focused on discovering new methods for passive aeroelastic control. Several new structural and material technologies are presented as potential enablers of aeroelastic tailoring, including selectively reinforced materials, functionally graded materials, fiber tow steered composite laminates, and various nonconventional structural designs. In addition, smart materials and structures whose properties or configurations change in response to external stimuli are presented as potential active approaches to aeroelastic tailoring.

  17. Sonic Interactions in Virtual Reality: State of the Art, Current Challenges, and Future Directions.

    Science.gov (United States)

    Serafin, Stefania; Geronazzo, Michele; Erkut, Cumhur; Nilsson, Niels C; Nordahl, Rolf

    2018-03-01

    A high-fidelity but efficient sound simulation is an essential element of any VR experience. Many of the techniques used in virtual acoustics are graphical rendering techniques suitably modified to account for sound generation and propagation. In recent years, several advances in hardware and software technologies have been facilitating the development of immersive interactive sound-rendering experiences. In this article, we present a review of the state of the art of such simulations, with a focus on the different elements that, combined, provide a complete interactive sonic experience. This includes physics-based simulation of sound effects and their propagation in space together with binaural rendering to simulate the position of sound sources. We present how these different elements of the sound design pipeline have been addressed in the literature, trying to find the trade-off between accuracy and plausibility. Recent applications and current challenges are also presented.

  18. The Consensus of Strategic Consensus: A Study of the State of the Art about the Theme

    Directory of Open Access Journals (Sweden)

    Marcelo Curth

    2018-04-01

    Full Text Available This paper aims to present the state of the art regarding the strategic consensus, emphasizing the approaches and the nature of the research methods used, the results obtained and the future agenda for this theme studies. Analyzing beyond the last four decades of publications, it was understood that relating the strategic consensus only with the performance and strategic levels can be seen as something limited, suggesting the need to bring to the researching field new aspects and backgrounds as innovation, the methods for generating new ideas, the occurrence beyond the Top Management Team level (TMT, among others. Moreover, concludes that the predominant approach the strategic consensus is a process and the methodology used is based on quantitative techniques. As a suggestion for future studies, this study indicates the investigation of situations in which the strategic consensus is not positive.

  19. State-of-the-art in modeling solute and sediment transport in rivers

    International Nuclear Information System (INIS)

    Sayre, W.W.

    1980-01-01

    This overview is structured around a comprehensive general model based on the conservation of mass principle as applied to dissolved and particulate constituents in rivers, with a few restricted but more specific examples that illustrate the state-of-the-art in modeling typical physical, chemical, and biological processes undergone by selected constituents in rivers. These examples include: simplified one- and two-dimensional formulations focusing on the hydrodynamic advection and dispersion mechanisms; a two-dimensional biochemial oxygen demand-dissolved oxygen model; a one-dimensional polychlorinated biphenyl model that includes uptake and release of constituent by suspended sediment, and deposition and erosion of contaminated particles; and a one-dimensional sediment transport model that accounts for interactions between the flow and the bed, and is capable of tracking dispersing slugs of sediment through cycles of erosion, entrainment, transport in suspension and as bed load, and burial and storage in the bed

  20. State of the Art of HVAC Technology in Europe and America

    DEFF Research Database (Denmark)

    Olesen, Bjarne W.; Kazanci, Ongun Berk

    2015-01-01

    of energy sources and energy generators are very much similar. This paper will present state-of the art-off energy efficient systems that will provide a good indoor environmental quality at a decreased energy use. Low Temperature Heating and High Temperature Cooling systems are an important requirement...... mechanisms and media to emit and remove heat or moisture from indoor spaces (e.g. hydronic radiant heating and cooling systems, fan-coil units, and active beams). The main differences between HVAC systems in Europe, North America and other parts of the world are often the indoor terminal units. Type...... for increasing the energy efficiency of HVAC (heating, ventilation and air-conditioning) systems and for increasing the amount of renewable energy used. Especially these types of systems are getting increasing attention in Europe and North-America. In the present study, operation characteristics, possibilities...

  1. Conservation physiology of marine fishes: state of the art and prospects for policy

    DEFF Research Database (Denmark)

    McKenzie, David J.; Axelsson, Michael; Chabot, Denis

    2016-01-01

    The state of the art of research on the environmental physiology of marine fishes is reviewed from the perspective of how it can contribute to conservation of biodiversity and fishery resources. A major constraint to application of physiological knowledge for conservation of marine fishes...... broad applications for conservation physiology research if it provides a universal mechanism to link physiological function with ecological performance and population dynamics of fishes, through effects of abiotic conditions on aerobic metabolic scope. The available data indicate, however......, that the paradigm is not universal, so further research is required on a wide diversity of species. Fish physiologists should interact closely with researchers developing ecological models, in order to investigate how integrating physiological information improves confidence in projecting effects of global change...

  2. State-of-the-art research: optimal investment in market-based electric power systems

    Energy Technology Data Exchange (ETDEWEB)

    Hope, Einar; Skjeret, Frode

    2008-04-15

    The purpose of this state-of-the-art research paper is to surveying the literature on investment in market based electric power systems as a background for identifying and discussing some important issues in the optimal design and operation of such systems. A fundamental distinction has to be made between investment in the competitive part of the power system (generation and trading) on the one hand and the natural monopoly part (network infrastructure) on the other. The paper starts with a listing and discussion on market characteristics and properties of electric power and goes on to discussing performance criteria and potential sources of market failure for optimal electric power investment. After the literature survey there is a discussion of conditions under which optimal investment may occur. (author). 78 refs., figs

  3. State-of-the-art technologies of gallium oxide power devices

    Science.gov (United States)

    Higashiwaki, Masataka; Kuramata, Akito; Murakami, Hisashi; Kumagai, Yoshinao

    2017-08-01

    Gallium oxide (Ga2 O3 ) has gained increased attention for power devices due to its superior material properties and the availability of economical device-quality native substrates. This review illustrates recent advances in Ga2 O3 device technologies, beginning with an overview of the social circumstances that motivate the development of new-generation switching devices. Following an introduction to the material properties of Ga2 O3 from the viewpoint of power electronics, growth technologies of Ga2 O3 bulk single crystals and epitaxial thin films are discussed. The fabrication and performance of state-of-the-art Ga2 O3 transistors and diodes are then described. We conclude by identifying the directions and challenges of Ga2 O3 power device development in the near future.

  4. The self-consistent multiparticle-multihole configuration mixing. Motivations, state of the art and perspectives

    Science.gov (United States)

    Pillet, N.; Robin, C.; Dupuis, M.; Hupin, G.; Berger, J.-F.

    2017-03-01

    The main objective of this paper is to review the state of the art of the multiparticle-multihole configuration mixing approach which was proposed and implemented using the Gogny interaction ˜ 10 years ago. Various theoretical aspects are re-analyzed when a Hamiltonian description is chosen: the link with exact many-body theories, the impact of truncations in the multiconfigurational space, the importance of defining single-particle orbitals which are consistent with the correlations introduced in the many-body wave function, the role of the self-consistency, and more practically the numerical convergence algorithm. Several applications done with the phenomenological effective Gogny interaction are discussed. Finally, future directions to extend and generalize the method are discussed.

  5. The self-consistent multiparticle-multihole configuration mixing. Motivations, state of the art and perspectives

    International Nuclear Information System (INIS)

    Pillet, N.; Dupuis, M.; Hupin, G.; Berger, J.F.; Robin, C.

    2017-01-01

    The main objective of this paper is to review the state of the art of the multiparticle-multihole configuration mixing approach which was proposed and implemented using the Gogny interaction ∝ 10 years ago. Various theoretical aspects are re-analyzed when a Hamiltonian description is chosen: the link with exact many-body theories, the impact of truncations in the multiconfigurational space, the importance of defining single-particle orbitals which are consistent with the correlations introduced in the many-body wave function, the role of the self-consistency, and more practically the numerical convergence algorithm. Several applications done with the phenomenological effective Gogny interaction are discussed. Finally, future directions to extend and generalize the method are discussed. (orig.)

  6. State-of-the-art and problems of X-ray diffraction analysis of biomacromolecules

    International Nuclear Information System (INIS)

    Andreeva, N. S.

    2006-01-01

    The state-of-the-art of X-ray diffraction studies of biomacromolecules is briefly characterized, and the challenge imposed by science is discussed. These studies are characterized by a wide scope and extensive use. This field of science is of great interest and is developed in many countries. The main purpose is to solve practical problems in medicine consisting in the design of drugs against various diseases. X-ray diffraction analysis of enzymes brought the pharmaceutical industry to a new level, thus allowing the rational design of drugs against formerly untreatable diseases. Modern X-ray diffraction studies of biomacromolecules laid the basis for a new science called structural biology. This method allows one to solve fundamental problems of physical chemistry for a new state of matter existing in living systems. Here, science poses numerous problems in analysis of X-ray diffraction data on biological macromolecules. Many of theses problems are in their infancy

  7. The state-of-the-art and prospects for the development of rechargeable lithium batteries

    International Nuclear Information System (INIS)

    Skundin, Aleksandr M; Efimov, Oleg N; Yarmolenko, Ol'ga V

    2002-01-01

    The state-of-the-art of investigations into the development and perfection of the most promising class of chemical power sources, namely, rechargeable lithium batteries, is considered. The main problems of designing the batteries with a metallic lithium electrode are formulated and the use of alternative negative electrodes is substantiated. Special attention is paid to the studies dealing with the principles of the performance of lithium-ion batteries as well as the key directions for the perfection of these devices, which mainly concern the elaboration of new materials for lithium-ion batteries. A separate section is devoted to the consideration of polymeric electrolytes for lithium and lithium-ion batteries. The bibliography includes 390 references.

  8. Optimizing the use of the "state-of-the-art" performance criteria.

    Science.gov (United States)

    Haeckel, Rainer; Wosniok, Werner; Streichert, Thomas

    2015-05-01

    The organizers of the first EFLM Strategic Conference "Defining analytical performance goals" identified three models for defining analytical performance goals in laboratory medicine. Whereas the highest level of model 1 (outcome studies) is difficult to implement, the other levels are more or less based on subjective opinions of experts, with models 2 (based on biological variation) and 3 (defined by the state-of-the-art) being more objective. A working group of the German Society of Clinical Chemistry and Laboratory Medicine (DGKL) proposes a combination of models 2 and 3 to overcome some disadvantages inherent to both models. In the new model, the permissible imprecision is not defined as a constant proportion of biological variation but by a non-linear relationship between permissible analytical and biological variation. Furthermore, the permissible imprecision is referred to the target quantity value. The biological variation is derived from the reference interval, if appropriate, after logarithmic transformation of the reference limits.

  9. Background and state of the art of near infrared spectroscopy in the forest sector base

    International Nuclear Information System (INIS)

    Muñiz, G.I.B. de; Magalhães, W.L.E.; Carneiro, M.E.; Viana, L.C.

    2012-01-01

    The knowledge of wood properties is the fundamental importance for the indication of the potential and use of this material. In the search for new alternatives for a fast, simple and reliable characterization, there are the non-destructive evaluations of wood. The near infrared spectroscopy (NIRS) has been used as a non-destructive method that allows qualitative and quantitative information of the constituents of biomass through the interaction of electromagnetic waves with near-infrared next to the sample. This work aims to provide a review of the technique of near infrared spectroscopy and its application in forestry. The technique is used in virtually all areas due to the level of development that this technology has reached in recent years. NIR spectroscopy has proved a quick and efficient replacement of several tests that determine the quality of the wood. This is a literature review and state of the art on the theme [pt

  10. Electric automation history and state of the art; Historia da automacao eletrica e estado da arte

    Energy Technology Data Exchange (ETDEWEB)

    Mendes, M.F. [Itaipu Binacional, Foz do Iguacu, PR (Brazil). Div. de Engenharia Eletronica e Sistemas de Controle], E-mail: mendes@ieee.org; Jardini, J.A. [Universidade de Sao Paulo (PEA/EP/USP), SP (Brazil). Escola Politecnica. Dept. de Engenharia de Energia e Automacao Eletricas], E-mail: jardini@pea.usp.br

    2009-07-01

    The article summarizes the history of electric systems automation, used in hydroelectric power plants, since the rise to the present day. Technologies are presented employed at various times, developments, the difference and the reasons for evolution. The emphasis is on today's modern systems technology, covering: communication, standardization, hardware, software, architecture, maintenance, operation and challenges. This work pretend to give subsidies for the design and implementation of automation systems electricity using state of the art. The scope are the new plants as well as those being modernized. Knowledge of history is important to investigate, to plan and evaluate the costs and benefits of automation systems for new electric plants and those that are undergoing processes technological upgrading.

  11. The study of urban systems by indicators. State of the art and implementation problems

    International Nuclear Information System (INIS)

    Del Ciello, R.; Napoleoni, S.

    2001-01-01

    The purpose of this work is to define the state of the art about the problem of the indicators and their capability in reading and foreseeing the urban complexity. Therefore, the theoretical elaborations and the suggestions developed in the report try to convert the different contributions in the Italian and international literature in a frame-work, focusing on those arguments which assume a key role in the study of the urban areas: (a) the problematic definition of the administrative, physics and functional boarders of the cities; (b) the selection of the indicators that describe the urban areas; (c) the description and quality of life and of environment quality in the cities; (d) the sustainability in urban areas [it

  12. Near-infrared sub-bandgap all-silicon photodetectors: state of the art and perspectives.

    Science.gov (United States)

    Casalino, Maurizio; Coppola, Giuseppe; Iodice, Mario; Rendina, Ivo; Sirleto, Luigi

    2010-01-01

    Due to recent breakthroughs, silicon photonics is now the most active discipline within the field of integrated optics and, at the same time, a present reality with commercial products available on the market. Silicon photodiodes are excellent detectors at visible wavelengths, but the development of high-performance photodetectors on silicon CMOS platforms at wavelengths of interest for telecommunications has remained an imperative but unaccomplished task so far. In recent years, however, a number of near-infrared all-silicon photodetectors have been proposed and demonstrated for optical interconnect and power-monitoring applications. In this paper, a review of the state of the art is presented. Devices based on mid-bandgap absorption, surface-state absorption, internal photoemission absorption and two-photon absorption are reported, their working principles elucidated and their performance discussed and compared.

  13. Near-Infrared Sub-Bandgap All-Silicon Photodetectors: State of the Art and Perspectives

    Directory of Open Access Journals (Sweden)

    Luigi Sirleto

    2010-11-01

    Full Text Available Due to recent breakthroughs, silicon photonics is now the most active discipline within the field of integrated optics and, at the same time, a present reality with commercial products available on the market. Silicon photodiodes are excellent detectors at visible wavelengths, but the development of high-performance photodetectors on silicon CMOS platforms at wavelengths of interest for telecommunications has remained an imperative but unaccomplished task so far. In recent years, however, a number of near-infrared all-silicon photodetectors have been proposed and demonstrated for optical interconnect and power-monitoring applications. In this paper, a review of the state of the art is presented. Devices based on mid-bandgap absorption, surface-state absorption, internal photoemission absorption and two-photon absorption are reported, their working principles elucidated and their performance discussed and compared.

  14. State of the art of durability-performance evaluation of hardened cement based on phase compositions

    International Nuclear Information System (INIS)

    Kurashige, Isao; Imoto, Harutake; Yamamoto, Takeshi; Hironaga, Michihiko

    2006-01-01

    Upgrading durability-performance evaluation technique for concrete is urgently demanded in connection to its application to radio-active waste repository which needs ultra long-term durability. Common concrete structures also require an advanced method for minimizing the life-cycle cost. The purpose of this research is to investigate current problems and future tasks on durability-performance evaluation of hardened cement from the view point of phase composition. Although the phase composition of hardened cement has not fully been reflected to durability-performance evaluation, it influences concrete durability as well as its pore structure. This report reviews state of the art of the factors affecting phase composition, analytical and experimental evaluation techniques for phase composition, and durability-performance evaluation methods of hardened cement based on phase composition. (author)

  15. Assessment of state-of-the-art dust emission scheme in GEOS

    Science.gov (United States)

    Darmenov, A.; Liu, X.; Prigent, C.

    2017-12-01

    The GEOS modeling system has been extended with state-of-the-art parameterization of dust emissions based on the vertical flux formulation described in Kok et al., 2014. The new dust scheme was coupled with the GOCART and MAM aerosol models. In the present study we compared dust emissions, aerosol optical depth (AOD) and radiative fluxes from GEOS experiments with the standard and new dust emissions. AOD from the model experiments were also compared with AERONET and satellite based AOD product. Based on this comparative analysis we concluded that the new parameterization improved the GEOS capability to model dust aerosols originating from African sources, however it led to overestimation of dust emissions from Asian and Middle-Eastern sources. Further regional tuning of key parameters controlling the threshold friction velocity may be required in order to attain more definitive and uniform improvement in the dust modeling skill with the newly implemented dust emissions scheme.

  16. Web mining in soft computing framework: relevance, state of the art and future directions.

    Science.gov (United States)

    Pal, S K; Talwar, V; Mitra, P

    2002-01-01

    The paper summarizes the different characteristics of Web data, the basic components of Web mining and its different types, and the current state of the art. The reason for considering Web mining, a separate field from data mining, is explained. The limitations of some of the existing Web mining methods and tools are enunciated, and the significance of soft computing (comprising fuzzy logic (FL), artificial neural networks (ANNs), genetic algorithms (GAs), and rough sets (RSs) are highlighted. A survey of the existing literature on "soft Web mining" is provided along with the commercially available systems. The prospective areas of Web mining where the application of soft computing needs immediate attention are outlined with justification. Scope for future research in developing "soft Web mining" systems is explained. An extensive bibliography is also provided.

  17. Proceedings of B Factories, the state of the art in accelerators, detectors and physics

    Energy Technology Data Exchange (ETDEWEB)

    Hitlin, D. (ed.) (California Inst. of Tech., Pasadena, CA (United States))

    1992-11-01

    The conference B Factories, The State of the Art in Accelerators, Detectors and Physics was held at Stanford Linear Accelerator Center on April 6-10, 1992. The guiding principle of the conference was to bring together accelerator physicists and high energy experimentalists and theorists at the same time, with the goal of encouraging communication in defining and solving problems in a way which cut across narrow areas of specialization. Thus the conference was, in large measure, two distinct conferences, one involving accelerator specialists, the other theorists and experimentalists. There were initial and closing plenary sessions, and three separate tracks of parallel sessions, called Accelerator, Detector/Physics and Joint Interest sessions. This report contains the papers of this conference, the general topics of these cover: vacuum system, lattice design, beam-beam interactions, rf systems, feedback systems, measuring instrumentation, the interaction region, radiation background, particle detectors, particle tracking and identification, data acquisition, and computing system, and particle theory.

  18. Automatic liquid handling for life science: a critical review of the current state of the art.

    Science.gov (United States)

    Kong, Fanwei; Yuan, Liang; Zheng, Yuan F; Chen, Weidong

    2012-06-01

    Liquid handling plays a pivotal role in life science laboratories. In experiments such as gene sequencing, protein crystallization, antibody testing, and drug screening, liquid biosamples frequently must be transferred between containers of varying sizes and/or dispensed onto substrates of varying types. The sample volumes are usually small, at the micro- or nanoliter level, and the number of transferred samples can be huge when investigating large-scope combinatorial conditions. Under these conditions, liquid handling by hand is tedious, time-consuming, and impractical. Consequently, there is a strong demand for automated liquid-handling methods such as sensor-integrated robotic systems. In this article, we survey the current state of the art in automatic liquid handling, including technologies developed by both industry and research institutions. We focus on methods for dealing with small volumes at high throughput and point out challenges for future advancements.

  19. Theory and state-of-the-art technology of software reliability

    International Nuclear Information System (INIS)

    Suzudo, Tomoaki; Watanabe, Norio

    1999-11-01

    Since FY 1997 , the Japan Atomic Energy Research Institute has been conducting a project , Study on Reliability of Digital I and C Systems. As part of the project , the methodologies and tools to improve software reliability were reviewed in order to examine the theory and the state-of-the-art technology in this field. It is surmised, as results from the review, that computerized software design and implementation tool (CASE tool), algebraic analysis to ensure the consistency between software requirement framework and its detailed design specification, and efficient test method using the internal information of the software (white-box test) at the validation phase just before the completion of the development will play a key role to enhance software reliability in the future. (author)

  20. Wind turbine siting: A summary of the state of the art

    Science.gov (United States)

    Hiester, T. R.

    1982-01-01

    The process of siting large wind turbines may be divided into two broad steps: site selection, and site evaluation. Site selection is the process of locating windy sites where wind energy development shows promise of economic viability. Site evaluation is the process of determining in detail for a given site the economic potential of the site. The state of the art in the first aspect of siting, site selection is emphasized. Several techniques for assessing the wind resource were explored or developed in the Federal Wind Energy Program. Local topography and meteorology will determine which of the techniques should be used in locating potential sites. None of the techniques can do the job alone, none are foolproof, and all require considerable knowledge and experience to apply correctly. Therefore, efficient siting requires a strategy which is founded on broad based application of several techniques without relying solely on one narrow field of expertise.

  1. Ceramic dental biomaterials and CAD/CAM technology: state of the art.

    Science.gov (United States)

    Li, Raymond Wai Kim; Chow, Tak Wah; Matinlinna, Jukka Pekka

    2014-10-01

    Ceramics are widely used as indirect restorative materials in dentistry because of their high biocompatibility and pleasing aesthetics. The objective is to review the state of the arts of CAD/CAM all-ceramic biomaterials. CAD/CAM all-ceramic biomaterials are highlighted and a subsequent literature search was conducted for the relevant subjects using PubMed followed by manual search. Developments in CAD/CAM technology have catalyzed researches in all-ceramic biomaterials and their applications. Feldspathic glass ceramic and glass infiltrated ceramic can be fabricated by traditional laboratory methods or CAD/CAM. The advent of polycrystalline ceramics is a direct result of CAD/CAM technology without which the fabrication would not have been possible. The clinical uses of these ceramics have met with variable clinical success. Multiple options are now available to the clinicians for the fabrication of aesthetic all ceramic restorations. Copyright © 2014 Japan Prosthodontic Society. Published by Elsevier Ltd. All rights reserved.

  2. State-of-the art of dc components for secondary power distribution of Space Station Freedom

    International Nuclear Information System (INIS)

    Krauthamer, S.; Gangal, M.; Das, R.

    1991-01-01

    The National Aeronautics and Space Administration has selected 120-Vdc secondary power distribution for Space Station Freedom. Although this high voltage level is new for space applications, it is well within the bounds for components and subsystems being developed and in some cases being used in aerospace, defense, and terrestrial applications. In this paper state-of-the-art components and subsystems for Space Station Freedom in terms of performance, size, and topology are examined. One objective is to inform the users of Space Station Freedom about what is available in power supplies and power control devices. The other objective is to stimulate the interest in the component industry so that more focused product development can be started. Based on results of this study, it is estimated that, with some redesign, modifications, and space qualification, many of these components may be applied to Space Station Freedom needs

  3. State of the art of large combustion plants and reference plants in Austria

    International Nuclear Information System (INIS)

    Boehmer, S.; Schindler, I.; Szednyj, I.; Winter, B.

    2003-01-01

    The aim of this study is to describe the state of the art of large combustion plants with respect to the European directive on integrated pollution prevention and control (IPPC-Directive 96/61/EG). For this purpose 10 sites where one or more thermal power or district heating plants with a rated thermal input of > 50 MW are operated were selected and described in detail. Only coal and oil fired power plants were chosen because of the larger environmental impacts compared to gas fired combustion units. Large industrial combustion plants, where in addition to regular fuels also special fuels and wastes are combusted (e.g. power plants from refineries and from the pulp and paper industry), and waste incineration plants are not treated in this study. The depiction of power plants comprises the whole chain of operation, starting from the description of the type and composition of fuels, the pretreatment and introduction into the boiler, the firing technology, measures for emission reduction (both into air and water) and treatment of solid waste and residues from combustion. Furthermore possibilities to increase energy efficiency and economic aspects are examined in this study. Also legal aspects are shortly described at the beginning of the respective chapters. An actual topic is co-combustion of biomass and waste in thermal power plants. Results of trial operation in Austrian power plants are summarized and conclusions were drawn with respect to environmental impacts of co-incineration, such as emissions into air and water, quality of solid wastes and residues from co-incineration. Important aspects such as shifting of pollutants and dilution effects are discussed. The study concludes with the chapter 'State of the art for power plants', which gives a survey of the relevant measures with particular attention to above mentioned crucial points. (author)

  4. A state of the art on penetration failure estimation under external vessel cooling

    International Nuclear Information System (INIS)

    Min, B. T.; Park, R. J.; Kang, K. H.; Cho, Y. R.; Kim, J. W.; Kim, S. B.; Park, S. Y.; Lee, K. Y.

    2000-04-01

    A state of the art on penetration failure was reviewed and analyzed to establish the direction of the experimental program in the KNGR and to decide the test section design. The interaction between the corium and the reactor vessel and the corium behavior in the lower plenum of the reactor vessel were analyzed to investigate the penetration effect on severe accident progression, and the TMI-2 accident was investigated in the point of penetration failure. Theoretical model and experiment results on penetration failure under the severe accident were investigated and reviewed to establish the direction of the experimental program on the estimation of the penetration failure in the KNGR. These results were compared with the TMI-2 results. The existing test facilities on penetration failure were investigated and reviewed to decide the test section design. It can be said from the state of the art review that penetration in the lower plenum of the reactor vessel is a week point in the reactor vessel failure under the severe accident, but the reactor vessel may not be failed by penetration failure in condition with the coolant supply to the penetration. Since the penetration is different with reactor types and there is no study on estimation of the penetration welding, it is necessary to investigate failure or not of the penetration in condition with external vessel cooling to maintain the reactor vessel integrity in KNGR. In the present experimental program on the integrity estimation of the KNGR penetration, the aluminum oxide melt by thermite reaction and the test section with one penetration of the real size and real material were selected. The melt mass, the pressure of the system, and the vessel geometry were selected as an experimental parameter. (author)

  5. State of the art in atomic resolution off-axis electron holography

    International Nuclear Information System (INIS)

    Linck, Martin; Freitag, Bert; Kujawa, Stephan; Lehmann, Michael; Niermann, Tore

    2012-01-01

    As proposed by Hannes Lichte, to resolve structure–property relations not only the question “Which atom is where?” but also the question “Which fields are around?” has to be answered. High-resolution off-axis electron holography opens up an access to these key questions in that it allows accessing the complete exit-wave of the object provided within the information limit of the microscope, i.e. amplitude and phase including atomic details such as position and species, and moreover, information about large area electric potentials and magnetic fields, which a conventional transmission electron microscope is blind for—also when using a Cs-corrector. For an excellent object exit-wave reconstruction, special care has to be taken on the hologram quality, i.e. interference fringe contrast and electron dose. Severe restrictions are given to signal resolution by the limited brightness of the electron source. Utilizing a new high-brightness Schottky field electron emitter in a state-of-the-art transmission electron microscope operated at 300 kV, the phase signal resolution at atomic resolution can significantly be enhanced. An improvement by at least a factor of 2.88 compared to the most recently reported single hologram at atomic resolution is found. To proof the applicability of this setup to real materials science problems, a grain boundary of gold has been investigated holographically. -- Highlights: ► Impact of the brightness on the reconstructed signal in electron holography. ► Factor 2.8 gain in signal quality by setup with a high brightness electron gun. ► Investigation of a grain boundary in gold with a state-of-the-art holography setup. ► A-posteriori aberration fine-tuning for true one Angstrom resolution in the object wave. ► Mistilt analysis on the atomic scale by numerical wave optics.

  6. Environmental impacts and benefits of state-of-the-art technologies for E-waste management.

    Science.gov (United States)

    Ikhlayel, Mahdi

    2017-10-01

    This study aims to evaluate the environmental impacts and benefits of state-of-the-art technologies for proper e-waste handling using Jordan as a case study. Life Cycle Assessment (LCA) was employed to evaluate five advanced management systems represent state-of-the-art treatment technologies, including sanitary landfilling; proper recycling of metals, materials, and precious metals (PMs); and incineration of plastic and the hazardous portion of printed circuit boards (PCBs). Six e-waste products that contribute the most to the e-waste in Jordan were included in the assessment of each scenario, which resulted in 30 total cases of e-waste management. The findings indicated that landfills for the entire components of the e-waste stream are the worst option and should be avoided. The most promising e-waste management scenario features integrated e-waste processes based on the concept of Integrated Waste Management (IWM), including recycling materials such as non-PMs and PMs, incinerating plastic and the hazardous content of PCBs using the energy recovered from incineration, and using sanitary landfills of residues. For this scenario, the best environmental performance was obtained for the treatment of mobile phones. Incineration of the portion of hazardous waste using energy recovery is an option that deserves attention. Because scenario implementation depends on more than just the environmental benefits (e.g., economic cost and technical aspects), the study proposes a systematic approach founded on the IWM concept for e-waste management scenario selection. Copyright © 2017 Elsevier Ltd. All rights reserved.

  7. State of the art vs biological variability: Comparison on hematology parameters using Spanish EQAS data.

    Science.gov (United States)

    Molina, A; Guiñon, L; Perez, A; Segurana, A; Bedini, J L; Reverter, J C; Merino, A

    2018-02-05

    It is important for clinical laboratories to maintain under control the possible sources of error in its analytical determinations. The objective of this work is to perform an analysis of the total error committed by laboratories using the data extracted from the Spanish External Quality Assessment Program in Hematology and to compare them with the specifications based on the biological variability proposed by the Ricós group. We analyzed a total of 3 89 000 results during the period 2015-2016 from the following quantitative schemes of Spanish External Quality Assessment Program: complete blood count, blood coagulation tests, differential leukocyte count, reticulocytes, hemoglobin A 2 , antithrombin, factor VIII, protein C, and von Willebrand factor. It has been considered as an indicator of the current performance the value of total error that 90% of laboratories are able to achieve, taking into account 75% of their results. We found some magnitudes whose biological variability specifications are achievable by most of the laboratories for either minimum, desirable, or optimum criteria: white blood cells, red blood cells, hemoglobin, hematocrit, mean corpuscular volume, mean corpuscular hemoglobin, platelets, fibrinogen, neutrophils, lymphocytes, eosinophils, von Willebrand factor, and protein C. However, current performance for mean corpuscular hemoglobin concentration and hemoglobin A 2 only allows to meet the specifications based on the state of the art. Our results reflect the feasibility of establishing specifications based on biological variability criteria or the state of the art, which may help to select the proper criteria for each parameter. © 2018 John Wiley & Sons Ltd.

  8. Fall prevention intervention technologies: A conceptual framework and survey of the state of the art.

    Science.gov (United States)

    Hamm, Julian; Money, Arthur G; Atwal, Anita; Paraskevopoulos, Ioannis

    2016-02-01

    In recent years, an ever increasing range of technology-based applications have been developed with the goal of assisting in the delivery of more effective and efficient fall prevention interventions. Whilst there have been a number of studies that have surveyed technologies for a particular sub-domain of fall prevention, there is no existing research which surveys the full spectrum of falls prevention interventions and characterises the range of technologies that have augmented this landscape. This study presents a conceptual framework and survey of the state of the art of technology-based fall prevention systems which is derived from a systematic template analysis of studies presented in contemporary research literature. The framework proposes four broad categories of fall prevention intervention system: Pre-fall prevention; Post-fall prevention; Fall injury prevention; Cross-fall prevention. Other categories include, Application type, Technology deployment platform, Information sources, Deployment environment, User interface type, and Collaborative function. After presenting the conceptual framework, a detailed survey of the state of the art is presented as a function of the proposed framework. A number of research challenges emerge as a result of surveying the research literature, which include a need for: new systems that focus on overcoming extrinsic falls risk factors; systems that support the environmental risk assessment process; systems that enable patients and practitioners to develop more collaborative relationships and engage in shared decision making during falls risk assessment and prevention activities. In response to these challenges, recommendations and future research directions are proposed to overcome each respective challenge. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

  9. Why does cervical cancer occur in a state-of-the-art screening program?

    Science.gov (United States)

    Castle, Philip E; Kinney, Walter K; Cheung, Li C; Gage, Julia C; Fetterman, Barbara; Poitras, Nancy E; Lorey, Thomas S; Wentzensen, Nicolas; Befano, Brian; Schussler, John; Katki, Hormuzd A; Schiffman, Mark

    2017-09-01

    The goal of cervical screening is to detect and treat precancers before some become cancer. We wanted to understand why, despite state-of-the-art methods, cervical cancers occured in relationship to programmatic performance at Kaiser Permanente Northern California (KPNC), where >1,000,000 women aged ≥30years have undergone cervical cancer screening by triennial HPV and cytology cotesting since 2003. We reviewed clinical histories preceding cervical cancer diagnoses to assign "causes" of cancer. We calculated surrogate measures of programmatic effectiveness (precancers/(precancers and cancers)) and diagnostic yield (precancers and cancers per 1000 cotests), overall and by age at cotest (30-39, 40-49, and ≥50years). Cancer was rare and found mainly in a localized (treatable) stage. Of 623 cervical cancers with at least one preceding or concurrent cotest, 360 (57.8%) were judged to be prevalent (diagnosed at a localized stage within one year or regional/distant stage within two years of the first cotest). Non-compliance with recommended screening and management preceded 9.0% of all cancers. False-negative cotests/sampling errors (HPV and cytology negative), false-negative histologic diagnoses, and treatment failures preceded 11.2%, 9.0%, and 4.3%, respectively, of all cancers. There was significant heterogeneity in the causes of cancer by histologic category (p<0.001 for all; p=0.002 excluding prevalent cases). Programmatic effectiveness (95.3%) and diagnostic yield were greater for squamous cell versus adenocarcinoma histology (p<0.0001) and both decreased with older ages (p trend <0.0001). A state-of-the-art intensive screening program results in very few cervical cancers, most of which are detected early by screening. Screening may become less efficient at older ages. Copyright © 2017 Elsevier Inc. All rights reserved.

  10. Translating state-of-the-art spinal cord MRI techniques to clinical use: A systematic review of clinical studies utilizing DTI, MT, MWF, MRS, and fMRI

    Directory of Open Access Journals (Sweden)

    Allan R. Martin

    2016-01-01

    Conclusions: State-of-the-art spinal cord MRI techniques are emerging with great potential to improve the diagnosis and management of various spinal pathologies, but the current body of evidence has only showed limited clinical utility to date. Among these imaging tools DTI is the most mature, but further work is necessary to standardize and validate its use before it will be adopted in the clinical realm. Large, well-designed studies with a priori hypotheses, standardized acquisition methods, detailed clinical data collection, and robust automated analysis techniques are needed to fully demonstrate the potential of these rapidly evolving techniques.

  11. Progressive image denoising through hybrid graph Laplacian regularization: a unified framework.

    Science.gov (United States)

    Liu, Xianming; Zhai, Deming; Zhao, Debin; Zhai, Guangtao; Gao, Wen

    2014-04-01

    Recovering images from corrupted observations is necessary for many real-world applications. In this paper, we propose a unified framework to perform progressive image recovery based on hybrid graph Laplacian regularized regression. We first construct a multiscale representation of the target image by Laplacian pyramid, then progressively recover the degraded image in the scale space from coarse to fine so that the sharp edges and texture can be eventually recovered. On one hand, within each scale, a graph Laplacian regularization model represented by implicit kernel is learned, which simultaneously minimizes the least square error on the measured samples and preserves the geometrical structure of the image data space. In this procedure, the intrinsic manifold structure is explicitly considered using both measured and unmeasured samples, and the nonlocal self-similarity property is utilized as a fruitful resource for abstracting a priori knowledge of the images. On the other hand, between two successive scales, the proposed model is extended to a projected high-dimensional feature space through explicit kernel mapping to describe the interscale correlation, in which the local structure regularity is learned and propagated from coarser to finer scales. In this way, the proposed algorithm gradually recovers more and more image details and edges, which could not been recovered in previous scale. We test our algorithm on one typical image recovery task: impulse noise removal. Experimental results on benchmark test images demonstrate that the proposed method achieves better performance than state-of-the-art algorithms.

  12. Fragment-based approaches to anti-HIV drug discovery: state of the art and future opportunities.

    Science.gov (United States)

    Huang, Boshi; Kang, Dongwei; Zhan, Peng; Liu, Xinyong

    2015-12-01

    The search for additional drugs to treat HIV infection is a continuing effort due to the emergence and spread of HIV strains resistant to nearly all current drugs. The recent literature reveals that fragment-based drug design/discovery (FBDD) has become an effective alternative to conventional high-throughput screening strategies for drug discovery. In this critical review, the authors describe the state of the art in FBDD strategies for the discovery of anti-HIV drug-like compounds. The article focuses on fragment screening techniques, direct fragment-based design and early hit-to-lead progress. Rapid progress in biophysical detection and in silico techniques has greatly aided the application of FBDD to discover candidate agents directed at a variety of anti-HIV targets. Growing evidence suggests that structural insights on key proteins in the HIV life cycle can be applied in the early phase of drug discovery campaigns, providing valuable information on the binding modes and efficiently prompting fragment hit-to-lead progression. The combination of structural insights with improved methodologies for FBDD, including the privileged fragment-based reconstruction approach, fragment hybridization based on crystallographic overlays, fragment growth exploiting dynamic combinatorial chemistry, and high-speed fragment assembly via diversity-oriented synthesis followed by in situ screening, offers the possibility of more efficient and rapid discovery of novel drugs for HIV-1 prevention or treatment. Though the use of FBDD in anti-HIV drug discovery is still in its infancy, it is anticipated that anti-HIV agents developed via fragment-based strategies will be introduced into the clinic in the future.

  13. Implementation and Use of State-of-the-Art, Cell-Based In Vitro Assays.

    Science.gov (United States)

    Langer, Gernot

    2016-01-01

    The impressive advances in the generation and interpretation of functional omics data have greatly contributed to a better understanding of the (patho-)physiology of many biological systems and led to a massive increase in the number of specific targets and phenotypes to investigate in both basic and applied research. The obvious complexity revealed by these studies represents a major challenge to the research community and asks for improved target characterisation strategies with the help of reliable, high-quality assays. Thus, the use of living cells has become an integral part of many research activities because the cellular context more closely represents target-specific interrelations and activity patterns. Although still predominant, the use of traditional two-dimensional (2D) monolayer cell culture models has been gradually complemented by studies based on three-dimensional (3D) spheroid (Sutherland 1988) and other 3D tissue culture systems (Santos et al. 2012; Matsusaki et al. 2014) in an attempt to employ model systems more closely representing the microenvironment of cells in the body. Hence, quite a variety of state-of-the-art cell culture models are available for the generation of novel chemical probes or the identification of starting points for drug development in translational research and pharma drug discovery. In order to cope with these information-rich formats and their increasing technical complexity, cell-based assay development has become a scientific research topic in its own right and is used to ensure the provision of significant, reliable and high-quality data outlasting any discussions related to the current "irreproducibility epidemic" (Dolgin 2014; Prinz et al. 2011; Schatz 2014). At the same time the use of cells in microplate assay formats has become state of the art and greatly facilitates rigorous cell-based assay development by providing the researcher with the opportunity to address the multitude of factors affecting the actual

  14. Performance of office workers under various enclosure conditions in state-of-the-art open workplaces

    Science.gov (United States)

    Yoon, Heakyung Cecilia

    The objective of this thesis is to more firmly establish the importance of physical attributes of workstations on the performance of workers undertaking a range of complex tasks while subjected to the visual and noise distractions prevalent in state-of-the-art North American office settings. This study investigates objective and subjective evaluations of noise and performance given a range of current physical work environments. The study provides criteria for architects, interior designers and managers, to select distraction-free office environments to deliver better performance. The concluding chapter helps to establish the importance of designing more acoustically responsible work settings in state-of-the-art office projects. With 102 subjects (23 native speakers of English per each of three workstation types), controlled experiments were completed over a six month testing period in three different work settings---four foot partitions on two sides, seated privacy with six foot partitions on three sides, and a closed office with eight foot partitions, a door and a ceiling, with two acoustic environments (office sounds with and without speech at a controlled 45 dBA level at the receiver), the experimental results were statistically significant. Another finding was the lack of a significant effect of background sound variations on simple or complex task performance. That implies the current acoustical evaluation tool, the Articulation Index, may not be an appropriate tool to adequately and conclusively assess the acoustic impact of open workplaces on individual performance. Concerning the impact of acoustic conditions on occupant performance from the experiments, Articulation Index values do not reflect the potential relation of workstation designs and subjects' performance and moods. However, NIC connected with speech privacy rating has the potential to be a better evaluation tool than AI for open workplaces. From the results of this thesis, it is predicted that

  15. Knowledge discovery in traditional Chinese medicine: state of the art and perspectives.

    Science.gov (United States)

    Feng, Yi; Wu, Zhaohui; Zhou, Xuezhong; Zhou, Zhongmei; Fan, Weiyu

    2006-11-01

    As a complementary medical system to Western medicine, traditional Chinese medicine (TCM) provides a unique theoretical and practical approach to the treatment of diseases over thousands of years. Confronted with the increasing popularity of TCM and the huge volume of TCM data, historically accumulated and recently obtained, there is an urgent need to explore these resources effectively by the techniques of knowledge discovery in database (KDD). This paper aims at providing an overview of recent KDD studies in TCM field. A literature search was conducted in both English and Chinese publications, and major studies of knowledge discovery in TCM (KDTCM) reported in these materials were identified. Based on an introduction to the state of the art of TCM data resources, a review of four subfields of KDTCM research was presented, including KDD for the research of Chinese medical formula, KDD for the research of Chinese herbal medicine, KDD for TCM syndrome research, and KDD for TCM clinical diagnosis. Furthermore, the current state and main problems in each subfield were summarized based on a discussion of existing studies, and future directions for each subfield were also proposed accordingly. A series of KDD methods are used in existing KDTCM researches, ranging from conventional frequent itemset mining to state of the art latent structure model. Considerable interesting discoveries are obtained by these methods, such as novel TCM paired drugs discovered by frequent itemset analysis, functional community of related genes discovered under syndrome perspective by text mining, the high proportion of toxic plants in the botanical family Ranunculaceae disclosed by statistical analysis, the association between M-cholinoceptor blocking drug and Solanaceae revealed by association rule mining, etc. It is particularly inspiring to see some studies connecting TCM with biomedicine, which provide a novel top-down view for functional genomics research. However, further developments

  16. Maximizing kinetic performance in supercritical fluid chromatography using state-of-the-art instruments.

    Science.gov (United States)

    Grand-Guillaume Perrenoud, Alexandre; Hamman, Chris; Goel, Meenakshi; Veuthey, Jean-Luc; Guillarme, Davy; Fekete, Szabolcs

    2013-11-01

    Recently, there has been a renewed interest in supercritical fluid chromatography (SFC), due to the introduction of state-of-the-art instruments and dedicated columns packed with small particles. However, the achievable kinetic performance and practical possibilities of such modern SFC instruments and columns has not been described in details until now. The goal of the present contribution was to provide some information about the optimal column dimensions (i.e. length, diameter and particle size) suitable for such state-of the-art systems, with respect to extra-column band broadening and system upper pressure limit. In addition, the reliability of the kinetic plot methodology, successfully applied in RPLC, was also evaluated under SFC conditions. Taking into account the system variance, measured at ∼85μL(2), on modern SFC instruments, a column of 3mm I.D. was ideally suited for the current technology, as the loss in efficiency remained reasonable (i.e. less than 10% decrease for k>6). Conversely, these systems struggle with 2.1mm I.D. columns (55% loss in N for k=5). Regarding particle size, columns packed with 5μm particles provided unexpectedly high minimum reduced plate height values (hmin=3.0-3.4), while the 3.5 and 1.7μm packing provided lower reduced plate heights hmin=2.2-2.4 and hmin=2.7-3.2, respectively. Considering the system upper pressure limit, it appears that columns packed with 1.7μm particles give the lowest analysis time for efficiencies up to 40,000-60,000 plates, if the mobile phase composition is in the range of 2-19% MeOH. The 3.5μm particles were attractive for higher efficiencies, particularly when the modifier percentage was above 20%, while 5μm was never kinetically relevant with modern SFC instruments, due to an obvious limitation in terms of upper flow rate value. The present work also confirms that the kinetic plot methodology could be successfully applied to SFC, without the need for isopycnic measurements, as the difference

  17. Conference Report: The Hunt for the Nibelungen Treasure. BVM Conference: "Qualitative Market Research—State of the Art and Prospects"

    OpenAIRE

    Thomas Kühn

    2005-01-01

    On March 9th, 2005, a conference entitled "Qualitative Market Research—State of the Art and Prospects" was held in Frankfurt/M., organized by the Association of German Social and Market Researchers (BVM e.V.). Because of the great interest generated by the conference it was repeated on April 20th, 2005. The aim of the conference was to bring together market research professionals from the supply and demand sector to discuss the state of the art of qualitative market research in Germany. Withi...

  18. State of the Art in Transfer Functions for Direct Volume Rendering

    KAUST Repository

    Ljung, Patric; Krü ger, Jens; Groller, Eduard; Hadwiger, Markus; Hansen, Charles D.; Ynnerman, Anders

    2016-01-01

    A central topic in scientific visualization is the transfer function (TF) for volume rendering. The TF serves a fundamental role in translating scalar and multivariate data into color and opacity to express and reveal the relevant features present in the data studied. Beyond this core functionality, TFs also serve as a tool for encoding and utilizing domain knowledge and as an expression for visual design of material appearances. TFs also enable interactive volumetric exploration of complex data. The purpose of this state-of-the-art report (STAR) is to provide an overview of research into the various aspects of TFs, which lead to interpretation of the underlying data through the use of meaningful visual representations. The STAR classifies TF research into the following aspects: dimensionality, derived attributes, aggregated attributes, rendering aspects, automation, and user interfaces. The STAR concludes with some interesting research challenges that form the basis of an agenda for the development of next generation TF tools and methodologies. © 2016 The Author(s) Computer Graphics Forum © 2016 The Eurographics Association and John Wiley & Sons Ltd. Published by John Wiley & Sons Ltd.

  19. Microwave ablation of renal tumors: state of the art and development trends.

    Science.gov (United States)

    Floridi, Chiara; De Bernardi, Irene; Fontana, Federico; Muollo, Alessandra; Ierardi, Anna Maria; Agostini, Andrea; Fonio, Paolo; Squillaci, Ettore; Brunese, Luca; Fugazzola, Carlo; Carrafiello, Gianpaolo

    2014-07-01

    In the last decades an increased incidence of new renal tumor cases has been for clinically localized, small tumors elderly patients, with medical comorbidities whom the risk of surgical complications may pose a greater risk of death than that due to the tumor itself. In these patients, unsuitable for surgical approach, thermal ablation represents a valid alternative to traditional surgery. Thermal ablation is a less invasive, less morbid treatment option thanks to reduced blood loss, lower incidence of complications during the procedure and a less long convalescence. At present, the most widely used thermal ablative techniques are cryoablation, radiofrequency ablation and microwave ablation (MWA). MWA offers many benefits of other ablation techniques and offers several other advantages: higher intratumoral temperatures, larger tumor ablation volumes, faster ablation times, the ability to use multiple applicators simultaneously, optimal heating of cystic masses and tumors close to the vessels and less procedural pain. This review aims to provide the reader with an overview about the state of the art of microwave ablation for renal tumors and to cast a glance on the new development trends of this technique.

  20. State-of-the-art and needs for jet instability and direct contact condensation model improvements

    International Nuclear Information System (INIS)

    Bousbia-Salah, A.; Moretti, F.; D'auria, F.; Bousbia-Salah, A.)

    2007-01-01

    There is a common understanding among thermal-hydraulic experts that the system analysis codes have currently reached an acceptable degree of maturity. Reliable application, however, is still limited to the validated domain. There is a growing need for qualified codes in assessing the safety of the existing reactors and for developing advanced reactor systems. Under conditions involving multi-phase flow simulations, the use of classical methods, mainly based upon the one dimensional approach, is not appropriate at all. The use of new computational models, such as the direct numerical simulation, large-eddy simulation or other advanced computational fluid dynamics methods, seems to be more suitable for more complex events. For this purpose, the European Commission financed NURESIM Integrated Project (as a part of the FP6 programme), was adopted to provide the initial step towards a Common European Standard Software Platform for modelling, recording and recovering computer data for nuclear reactor simulations. Some of the studies carried out at the University of Pisa within the framework of the NURESIM project are presented in this paper. They mainly concern the investigation of two critical phenomena connected with jet instabilities and direct contact condensation that occur during emergency core cooling. Through these examples, the state-of-the-art and the need for model improvements and validation against new experimental data for the sake of getting a better understanding and more accurate predictions are discussed. (author)

  1. Exploration of dual supply voltage logic synthesis in state-of-the-art ASIC design flows

    Directory of Open Access Journals (Sweden)

    T. Mahnke

    2003-01-01

    Full Text Available Dual supply voltage scaling (DSVS for logiclevel power optimization at the has increasingly attracted attention over the last few years. However, mainly due to the fact that the most widely used design tools do not support this new technique, it has still not become an integral part of real-world design flows. In this paper, a novel logic synthesis methodology that enables DSVS while relying entirely on standard tools is presented. The key to this methodology is a suitably modeled dual supply voltage (DSV standard cell library. A basic evaluation of the methodology has been carried out on a number of MCNC benchmark circuits. In all these experiments, the results of state-of-the-art powerdriven single supply voltage (SSV logic synthesis have been used as references in order to determine the true additional benefit of DSVS. Compared with the results of SSV power optimization, additional power reductions of 10% on average have been achieved. The results prove the feasibility of the new approach and reveal its greater efficiency in comparison with a well-known dedicated DSVS algorithm. Finally, the methodology has been applied to an embedded microcontroller core in order to further explore the potentials and limitations of DSVS in an existing industrial design environment.

  2. Techniques and Emerging Trends for State of the Art Equipment Maintenance Systems—A Bibliometric Analysis

    Directory of Open Access Journals (Sweden)

    Burkhard Hoppenstedt

    2018-06-01

    Full Text Available The increasing interconnection of machines in industrial production on one hand, and the improved capabilities to store, retrieve, and analyze large amounts of data on the other, offer promising perspectives for maintaining production machines. Recently, predictive maintenance has gained increasing attention in the context of equipment maintenance systems. As opposed to other approaches, predictive maintenance relies on machine behavior models, which offer several advantages. In this highly interdisciplinary field, there is a lack of a literature review of relevant research fields and realization techniques. To obtain a comprehensive overview on the state of the art, large data sets of relevant literature need to be considered and, best case, be automatically partitioned into relevant research fields. A proper methodology to obtain such an overview is the bibliometric analysis method. In the presented work, we apply a bibliometric analysis to the field of equipment maintenance systems. To be more precise, we analyzed clusters of identified literature with the goal to obtain deeper insight into the related research fields. Moreover, cluster metrics reveal the importance of a single paper and an investigation of the temporal cluster development indicates the evolution of research topics. In this context, we introduce a new measure to compare results from different time periods in an appropriate way. In turn, among others, this simplifies the analysis of topics, with a vast amount of subtopics. Altogether, the obtained results particularly provide a comprehensive overview of established techniques and emerging trends for equipment maintenance systems.

  3. State-of-the-Art Pediatric Hypnosis Training: Remodeling Curriculum and Refining Faculty Development.

    Science.gov (United States)

    Kohen, Daniel P; Kaiser, Pamela; Olness, Karen

    2017-01-01

    Training in pediatric hypnosis has been part of clinical hypnosis education in the United States since 1976. Workshops expanded over time and are now taught by highly experienced pediatric clinicians across the globe. In 1987, a small vanguard of North American faculty, academic pediatricians, and pediatric psychologists taught a 3-day pediatric hypnosis workshop at the national meeting of the Society for Developmental and Behavioral Pediatrics (SDBP). This model of annual tri-level concurrent workshops (introductory, intermediate, and advanced) was sponsored by the SDBP for 24 years. In 2009, the National Pediatric Hypnosis Training Institute (NPHTI) assembled, and in 2010, offered its first annual workshops. This article documents this history of pediatric hypnosis education and describes NPHTI's remodeling and ongoing refinement toward a state-of-the-art curriculum with innovative methodology based upon (1) current research about adult experiential and small group learning; (2) design principles for presentations that maximize adult learning and memory; and (3) evaluations by participants and faculty. These underpinnings-including clinical training videos, individualized learning choices, emphasis on personalized, goal-oriented sessions, and advances in faculty selection, and ongoing development-are applicable to adult training models. Integration of developmental and self-regulation strategies may be more unique to pediatric hypnosis skills training programs. The conclusion proposes expansion of pediatric hypnosis education and elimination of related barriers toward goals that all children learn self-hypnosis (SH) for mind-body health.

  4. The state-of-the-art in the rehabilitation of a PIONEER Crane

    Directory of Open Access Journals (Sweden)

    Cosmin Bledea

    2005-10-01

    Full Text Available The paper is focused on the analysis about the state of stress in the girder of a PIONEER crane with a prescribed vertical loading of 0,75 tones belonging to the thermal power-station Timisoara. The analysis has been performed with a FEA software (COSMOS/M which is able to conduct to important results regarding the map of stress, especially in areas where high stress concentration are present. There have been automatically combined a wide range of finite elements: shell, brick, beam,truss-cable simulating the different zones of the girder. The combination of the most advanced standard components as well the implementation of the modular product concepts and the state-of-the-art regarding the design of cranes must be in a perfect agreement with the state of stress in the metallic structure. In the end, a comparison between the FEA results and the classical calculus with the strength of materials theory has been performed.

  5. Suicide in the Kurdistan Region of Iraq, state of the art.

    Science.gov (United States)

    Hanna, Vian Nissan; Ahmad, Abdulbaghi

    2009-01-01

    In recent years the, incidence of suicide in Kurdistan has been increasing, especially among females, to a degree it cannot be neglected. Consequently, attention was given to this phenomena and the aggressive method of suicide used by young peoples, especially females, in Kurdistan. In attempt to obtain an objective picture of the frequently media-reported suicide among youths and women in the Kurdistan Region of Iraq. The responsible authorities and medical service units in the region were visited to collect information, and the available data were explored to produce a state-of-the-art overview on the subject. Because of insufficient documentation and lack of systematic registration, the data on suicide were scattered and difficult to evaluate. However, the findings did confirm that suicide exists as a serious problem in the society in Kurdistan, particularly among females. Urgent attention is demanded from the responsible authorities and organizations concerned in the region. Further research is needed to investigate the exact extent of suicide and its correlates in the society in Kurdistan, in order to plan for effective preventive measures.

  6. Corrected and republished: Suicide in the Kurdistan Region of Iraq, state of the art.

    Science.gov (United States)

    Hanna, Vian Nissan; Ahmad, Abdulbaghi

    2013-04-01

    In recent years the, incidence of suicide in Kurdistan has been increasing, especially among females, to a degree it cannot be neglected. Consequently, attention was given to this phenomena and the aggressive method of suicide used by young peoples, especially females, in Kurdistan. In attempt to obtain an objective picture of the frequently media-reported suicide among youths and women in the Kurdistan Region of Iraq. The responsible authorities and medical service units in the region were visited to collect information, and the available data were explored to produce a state-of-the-art overview on the subject. Because of insufficient documentation and lack of systematic registration, the data on suicide were scattered and difficult to evaluate. However, the findings did confirm that suicide exists as a serious problem in the society in Kurdistan, particularly among females. Urgent attention is demanded from the responsible authorities and organizations concerned in the region. Further research is needed to investigate the exact extent of suicide and its correlates in the society in Kurdistan, in order to plan for effective preventive measures. Burn, Iraq, Kurdistan, Suicide, Young.

  7. Biological network extraction from scientific literature: state of the art and challenges.

    Science.gov (United States)

    Li, Chen; Liakata, Maria; Rebholz-Schuhmann, Dietrich

    2014-09-01

    Networks of molecular interactions explain complex biological processes, and all known information on molecular events is contained in a number of public repositories including the scientific literature. Metabolic and signalling pathways are often viewed separately, even though both types are composed of interactions involving proteins and other chemical entities. It is necessary to be able to combine data from all available resources to judge the functionality, complexity and completeness of any given network overall, but especially the full integration of relevant information from the scientific literature is still an ongoing and complex task. Currently, the text-mining research community is steadily moving towards processing the full body of the scientific literature by making use of rich linguistic features such as full text parsing, to extract biological interactions. The next step will be to combine these with information from scientific databases to support hypothesis generation for the discovery of new knowledge and the extension of biological networks. The generation of comprehensive networks requires technologies such as entity grounding, coordination resolution and co-reference resolution, which are not fully solved and are required to further improve the quality of results. Here, we analyse the state of the art for the extraction of network information from the scientific literature and the evaluation of extraction methods against reference corpora, discuss challenges involved and identify directions for future research. © The Author 2013. Published by Oxford University Press. For Permissions, please email: journals.permissions@oup.com.

  8. Whole abdomen irradiation in epithelial ovarian cancer - state of the art

    International Nuclear Information System (INIS)

    Gocheva, L.

    2009-01-01

    Epithelial ovarian cancer (OC) as a malignancy which poses multiple challenges has led to growing attention and concern during recent years. The not very noteworthy treatment results achieved during the last three decades with contemporary chemotherapeutic schemes have led to the need for research and development of new therapeutic approaches, as well as to a resurgence of interest in radiotherapy (RT) as part of a combined modality approach and as salvage therapy for patients with small volume persistent disease after primary cytoreductive surgery and chemotherapy. This article reviews the state of the art of whole abdomen irradiation (WAI) (excluding the moving strip field technique) as part of the complex treatment of epithelial OC. The prognostic factors and risk groups of epithelial OC are discussed as indicators for WAI, giving in detail the applied treatment modalities, fractionation and total doses. Toxicity and second primary malignancies following WAI are analyzed. The clinical experience accumulated during the last decades, as adjuvant, consolidative, salvage and palliative WAI in combined treatment of epithelial OC, is presented. Current issues in the radiotherapeutic management are discussed along with ideas for future clinical research directions. (author)

  9. Radiations FR of telephone antennas and Public health: the state of the art

    International Nuclear Information System (INIS)

    Ubeda Maeso, A.; Trillo Ruiz, M. A.

    1999-01-01

    Today, mobile telephone is envisioned as one of the most significant innovations in communication. The growing development of this system asks for increasing amounts of antennas, installed in base transceiver stations (BTS) connection mobile stations (MS, hand held phones) to each other and to the conventional telephone network. Depending on the area, antennas are generally mounted in BTS located either on the top of buildings (in urban areas) or in towers (in rural or less populated areas). In both of the cases, the visual impact of BTS is significant for people living or working close to them. This visual evidence, together with some information, usually inconsistent or incomplete, released in media other than the scientific literature, have generated increasing feelings of phobia to alleged detrimental consequences of the uncontrolled exposure to radio waves emitted by the antennas. Such feelings, identified previously in countries where mobile telephony has been used for years in a regular basis, are now significantly growing in Spain and motivate many of the questions asked to information services of public agencies and institutions. The aim of the present article is to address some of the most frequently asked questions on the topic and to review the state of the art of our knowledge on the putative effects of the exposure to the electromagnetic radiation emitted by the aerials. Also, elementary notions are provided on the functioning of mobile telephony that may help the reader to better understand some technical aspects concerning the topic. (Author) 54 refs

  10. West Nile Virus State of the Art Report of MALWEST Project

    Science.gov (United States)

    Marka, Andriani; Diamantidis, Alexandros; Papa, Anna; Valiakos, George; Chaintoutis, Serafeim C.; Doukas, Dimitrios; Tserkezou, Persefoni; Giannakopoulos, Alexios; Papaspyropoulos, Konstantinos; Patsoula, Eleni; Badieritakis, Evangelos; Baka, Agoritsa; Tseroni, Maria; Pervanidou, Danai; Papadopoulos, Nikos T.; Koliopoulos, George; Tontis, Dimitrios; Dovas, Chrysostomos I.; Billinis, Charalambos; Tsakris, Athanassios; Kremastinou, Jenny; Hadjichristodoulou, Christos

    2013-01-01

    During the last three years Greece is experiencing the emergence of West Nile virus (WNV) epidemics. Within this framework, an integrated surveillance and control programme (MALWEST project) with thirteen associate partners was launched aiming to investigate the disease and suggest appropriate interventions. One out of seven work packages of the project is dedicated to the State of the Art report for WNV. Three expert working groups on humans, animals and mosquitoes were established. Medical databases (PubMed, Scopus) were searched together with websites: e.g., WHO, CDC, ECDC. In total, 1,092 relevant articles were initially identified and 258 of them were finally included as references regarding the current knowledge about WNV, along with 36 additional sources (conference papers, reports, book chapters). The review is divided in three sections according to the fields of interest: (1) WNV in humans (epidemiology, molecular characteristics, transmission, diagnosis, treatment, prevention, surveillance); (2) WNV in animals (epidemiological and transmission characteristics concerning birds, horses, reptiles and other animal species) and (3) WNV in mosquitoes (control, surveillance). Finally, some examples of integrated surveillance programmes are presented. The introduction and establishment of the disease in Greece and other European countries further emphasizes the need for thorough research and broadening of our knowledge on this viral pathogen. PMID:24317379

  11. Combined Antimicrobial Activity of Photodynamic Inactivation and Antimicrobials–State of the Art

    Directory of Open Access Journals (Sweden)

    Agata Wozniak

    2018-05-01

    Full Text Available Antimicrobial photodynamic inactivation (aPDI is a promising tool for the eradication of life-threatening pathogens with different profiles of resistance. This study presents the state-of-the-art published studies that have been dedicated to analyzing the bactericidal effects of combining aPDI and routinely applied antibiotics in in vitro (using biofilm and planktonic cultures and in vivo experiments. Furthermore, the current paper reviews the methodology used to obtain the published data that describes the synergy between these antimicrobial approaches. The authors are convinced that even though the combined efficacy of aPDI and antimicrobials could be investigated with the wide range of methods, the use of a unified experimental methodology that is in agreement with antimicrobial susceptibility testing (AST is required to investigate possible synergistic cooperation between aPDI and antimicrobials. Conclusions concerning the possible synergistic activity between the two treatments can be drawn only when appropriate assays are employed. It must be noticed that some of the described papers were just aimed at determination if combined treatments exert enhanced antibacterial outcome, without following the standard methodology to evaluate the synergistic effect, but in most of them (18 out of 27 authors indicated the existence of synergy between described antibacterial approaches. In general, the increase in bacterial inactivation was observed when both therapies were used in combination.

  12. Building Extraction from Airborne Laser Scanning Data: An Analysis of the State of the Art

    Directory of Open Access Journals (Sweden)

    Ivan Tomljenovic

    2015-03-01

    Full Text Available This article provides an overview of building extraction approaches applied to Airborne Laser Scanning (ALS data by examining elements used in original publications, such as data set area, accuracy measures, reference data for accuracy assessment, and the use of auxiliary data. We succinctly analyzed the most cited publication for each year between 1998 and 2014, resulting in 54 ISI-indexed articles and 14 non-ISI indexed publications. Based on this, we position some built-in features of ALS to create a comprehensive picture of the state of the art and the progress through the years. Our analyses revealed trends and remaining challenges that impact the community. The results show remaining deficiencies, such as inconsistent accuracy assessment measures, limitations of independent reference data sources for accuracy assessment, relatively few documented applications of the methods to wide area data sets, and the lack of transferability studies and measures. Finally, we predict some future trends and identify some gaps which existing approaches may not exhaustively cover. Despite these deficiencies, this comprehensive literature analysis demonstrates that ALS data is certainly a valuable source of spatial information for building extraction. When taking into account the short civilian history of ALS one can conclude that ALS has become well established in the scientific community and seems to become indispensable in many application fields.

  13. Analogue scale modelling of extensional tectonic processes using a large state-of-the-art centrifuge

    Science.gov (United States)

    Park, Heon-Joon; Lee, Changyeol

    2017-04-01

    Analogue scale modelling of extensional tectonic processes such as rifting and basin opening has been numerously conducted. Among the controlling factors, gravitational acceleration (g) on the scale models was regarded as a constant (Earth's gravity) in the most of the analogue model studies, and only a few model studies considered larger gravitational acceleration by using a centrifuge (an apparatus generating large centrifugal force by rotating the model at a high speed). Although analogue models using a centrifuge allow large scale-down and accelerated deformation that is derived by density differences such as salt diapir, the possible model size is mostly limited up to 10 cm. A state-of-the-art centrifuge installed at the KOCED Geotechnical Centrifuge Testing Center, Korea Advanced Institute of Science and Technology (KAIST) allows a large surface area of the scale-models up to 70 by 70 cm under the maximum capacity of 240 g-tons. Using the centrifuge, we will conduct analogue scale modelling of the extensional tectonic processes such as opening of the back-arc basin. Acknowledgement This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (grant number 2014R1A6A3A04056405).

  14. Nanoscale surface modifications of medically relevant metals: state-of-the art and perspectives

    Science.gov (United States)

    Variola, Fabio; Brunski, John B.; Orsini, Giovanna; Tambasco de Oliveira, Paulo; Wazen, Rima; Nanci, Antonio

    2011-02-01

    Evidence that nanoscale surface properties stimulate and guide various molecular and biological processes at the implant/tissue interface is fostering a new trend in designing implantable metals. Cutting-edge expertise and techniques drawn from widely separated fields, such as nanotechnology, materials engineering and biology, have been advantageously exploited to nanoengineer surfaces in ways that control and direct these processes in predictable manners. In this review, we present and discuss the state-of-the-art of nanotechnology-based approaches currently adopted to modify the surface of metals used for orthopedic and dental applications, and also briefly consider their use in the cardiovascular field. The effects of nanoengineered surfaces on various in vitro molecular and cellular events are firstly discussed. This review also provides an overview of in vivo and clinical studies with nanostructured metallic implants, and addresses the potential influence of nanotopography on biomechanical events at interfaces. Ultimately, the objective of this work is to give the readership a comprehensive picture of the current advances, future developments and challenges in the application of the infinitesimally small to biomedical surface science. We believe that an integrated understanding of the in vitro and particularly of the in vivo behavior is mandatory for the proper exploitation of nanostructured implantable metals and, indeed, of all biomaterials.

  15. Sensitivity study of state-of-the-art common cause failure analysis

    International Nuclear Information System (INIS)

    Guey, Ching

    2004-01-01

    Common cause failures (CCFs) have been touted as one of the major contributors of plant risk due to its pervasive nature and somewhat conservative approaches taken in most Probabilistic Risk Assessment (PRA) studies. The objectives of this study are twofold: First, to gain a better understanding on the impact of various CCF failure probability on the overall plant risk. Secondly, to appreciate the state-of-the-art CCF modelling and data limitations for applications to a full-scale plant risk assessment. The sensitivity study of varying the CCF parameters for different cases indicates that CCF data differences based on the various cases commonly adopted in the PRAs yield core damage frequency variations between 8.5% to -25.6% of the baseline case. It appears that only if CCFs are guaranteed to occur, the core damage frequency would change significantly, by approximately a factor of 5. This suggests that prevention of CCFs is more important than dwelling on the analytical differences in the finer interpretation of the operating experience to develop the CCF parameters. (author)

  16. Soft Robotics: Biological Inspiration, State of the Art, and Future Research

    Directory of Open Access Journals (Sweden)

    Deepak Trivedi

    2008-01-01

    Full Text Available Traditional robots have rigid underlying structures that limit their ability to interact with their environment. For example, conventional robot manipulators have rigid links and can manipulate objects using only their specialised end effectors. These robots often encounter difficulties operating in unstructured and highly congested environments. A variety of animals and plants exhibit complex movement with soft structures devoid of rigid components. Muscular hydrostats (e.g. octopus arms and elephant trunks are almost entirely composed of muscle and connective tissue and plant cells can change shape when pressurised by osmosis. Researchers have been inspired by biology to design and build soft robots. With a soft structure and redundant degrees of freedom, these robots can be used for delicate tasks in cluttered and/or unstructured environments. This paper discusses the novel capabilities of soft robots, describes examples from nature that provide biological inspiration, surveys the state of the art and outlines existing challenges in soft robot design, modelling, fabrication and control.

  17. Communication of emergency public warnings: A social science perspective and state-of-the-art assessment

    Energy Technology Data Exchange (ETDEWEB)

    Mileti, D.S. (Colorado State Univ., Fort Collins, CO (USA)); Sorensen, J.H. (Oak Ridge National Lab., TN (USA))

    1990-08-01

    More than 200 studies of warning systems and warning response were reviewed for this social science perspective and state-of-the-art assessment of communication of emergency public warnings. The major findings are as follows. First, variations in the nature and content of warnings have a large impact on whether or not the public heeds the warning. Relevant factors include the warning source; warning channel; the consistency, credibility, accuracy, and understandability of the message; and the warning frequency. Second, characteristics of the population receiving the warning affect warning response. These include social characteristics such as gender, ethnicity and age, social setting characteristics such as stage of life or family context, psychological characteristics such as fatalism or risk perception, and knowledge characteristics such as experience or training. Third, many current myths about public response to emergency warning are at odds with knowledge derived from field investigations. Some of these myths include the keep it simple'' notion, the cry wolf'' syndrome, public panic and hysteria, and those concerning public willingness to respond to warnings. Finally, different methods of warning the public are not equally effective at providing an alert and notification in different physical and social settings. Most systems can provide a warning given three or more hours of available warning time. Special systems such as tone-alert radios are needed to provide rapid warning. 235 refs., 8 figs., 2 tabs.

  18. Methodologies and applications for critical infrastructure protection: State-of-the-art

    International Nuclear Information System (INIS)

    Yusta, Jose M.; Correa, Gabriel J.; Lacal-Arantegui, Roberto

    2011-01-01

    This work provides an update of the state-of-the-art on energy security relating to critical infrastructure protection. For this purpose, this survey is based upon the conceptual view of OECD countries, and specifically in accordance with EU Directive 114/08/EC on the identification and designation of European critical infrastructures, and on the 2009 US National Infrastructure Protection Plan. The review discusses the different definitions of energy security, critical infrastructure and key resources, and shows some of the experie'nces in countries considered as international reference on the subject, including some information-sharing issues. In addition, the paper carries out a complete review of current methodologies, software applications and modelling techniques around critical infrastructure protection in accordance with their functionality in a risk management framework. The study of threats and vulnerabilities in critical infrastructure systems shows two important trends in methodologies and modelling. A first trend relates to the identification of methods, techniques, tools and diagrams to describe the current state of infrastructure. The other trend accomplishes a dynamic behaviour of the infrastructure systems by means of simulation techniques including systems dynamics, Monte Carlo simulation, multi-agent systems, etc. - Highlights: → We examine critical infrastructure protection experiences, systems and applications. → Some international experiences are reviewed, including EU EPCIP Plan and the US NIPP programme. → We discuss current methodologies and applications on critical infrastructure protection, with emphasis in electric networks.

  19. State-of-the-art risk-based approach to spill contingency planning and risk management

    International Nuclear Information System (INIS)

    Schmidt Etkin, Dagmar; Reilly, Timothy; French McCay, Deborah

    2011-01-01

    The paper proposes incorporating a comprehensive examination of spill risk into risk management and contingency planning, and applying state-of-the-art modeling tools to evaluate various alternatives for appropriate spill response measures and optimize protective responses. The approach allows spill contingency planners and decision-makers to determine the types of spill scenarios that may occur in a particular location or from a particular source and calculate the probability distribution of the various scenarios. The spill probability information is useful in assessing and putting into perspective the various costs options for spill control systems that will be recommended ultimately. Using advanced modeling tools helps in estimating the potential environmental and socioeconomic consequences of each spill scenario based on location-specific factors over a range of stochastic possibilities, simulating spill scenarios and determining optimal responses and protection strategies. The benefits and costs of various response alternatives and variations in response time can be calculated and modeling tools for training and risk allocation/transfer purposes used.

  20. Neurofeedback therapy for enhancing visual attention: state-of-the-art and challenges

    Directory of Open Access Journals (Sweden)

    Mehdi Ordikhani-Seyedlar

    2016-08-01

    Full Text Available We have witnessed a rapid development of brain-computer interfaces (BCIs linking the brain to external devices. BCIs can be utilized to treat neurological conditions and even to augment brain functions. BCIs offer a promising treatment for mental disorders, including disorders of attention. Here we review the current state of the art and challenges of attention-based BCIs, with a focus on visual attention. Attention-based BCIs utilize electroencephalograms (EEGs or other recording techniques to generate neurofeedback, which patients use to improve their attention, a complex cognitive function. Although progress has been made in the studies of neural mechanisms of attention, extraction of attention-related neural signals needed for BCI operations is a difficult problem. To attain good BCI performance, it is important to select the features of neural activity that represent attentional signals. BCI decoding of attention-related activity may be hindered by the presence of different neural signals. Therefore, BCI accuracy can be improved by signal processing algorithms that dissociate signals of interest from irrelevant activities. Notwithstanding recent progress, optimal processing of attentional neural signals remains a fundamental challenge for the development of efficient therapies for disorders of attention.

  1. State of the art on fault-tolerant real time distributed systems

    International Nuclear Information System (INIS)

    Levkov, V.

    1992-06-01

    The integration of new computerized functions in power plant, and especially nuclear power plant, control and instrumentation systems implies more and more stringent requirements as to communication system reliability. For if an item of equipment, or even a computer program, can be validated and qualified, no formal qualification procedure is presently imposed on communication networks. This is certainly due to the relative immaturity of these networks, but also to their complexity. It is for this reason that, in the context of preparation for the future PWR 2000 standardized nuclear plants, it would seem appropriate to take a look at fault-tolerant communication systems. Since C and I type applications (in the control room) are divided between several computers and are required to contend with extremely severe time constraints, EDF has undertaken investigation of fault-tolerant, real time distributed systems. This paper summarized the state of the art in the field as it appears from discussion with computer manufacturers, academics and research workers on related projects. The results obtained were then used to determine trends as to ''promising'' solutions. The paper concludes with recommended study programs for the PCC department of EDF/R and DD for the next few years. (author), 9 figs., 10 refs., 2 annexes

  2. State of the art of solid state dosimetry; Estado da arte em dosimetria do estado solido

    Energy Technology Data Exchange (ETDEWEB)

    Souza, Susana O., E-mail: sosouza@ufs.br [Universidade Federal de Sergipe (UFS), Sao Cristovao, SE (Brazil); Yamamoto, Takayoshi [Radioisotope Research Center, Osaka University (Japan); D' Errico, Francesco, E-mail: francesco.derrico@yale.edu [Yale University, School of Medicine, CT (United States)

    2014-07-01

    Passive solid-state detectors still dominate the personal dosimetry field. This article provides state of the art in this field and summarizes the most recent works presented on TL, OSL and RPL during the 17th International Conference on Solid State Dosimetry held in Recife in September 2013. The Article contains in particular the techniques Thermoluminescence (TL), Optically Stimulated Luminescence (OSL), radio photoluminescence (RPL). Thermoluminescence has the biggest advantage of the wide availability of commercial materials for dosimetry, and the nature tissue-equivalent of several of these materials. The limitation of the TL dosimetry presents fading luminance signal and the need for high temperatures to obtain the signal. The Optically Stimulated Luminescence has the advantages of high sensitivity, the possibility of multiple reading, while its limit is the need to use response compensating filters in addition to the high cost of equipment and dosimeters still restricted very few options trading . The radio photoluminescence has a reading that is completely non-destructive, but their dosimeters present lack of tissue-equivalent and a high cost. Presents the details of the techniques and the advantages and limitations of each of these will be discussed.

  3. Waste management state-of-the-art review for mixed-oxide fuel fabrication facilities

    International Nuclear Information System (INIS)

    Woodsum, H.C.; Goodman, J.

    1977-11-01

    This report provides a state-of-the-art review of the waste management for mixed-oxide (MOX) fuel fabrication facilities. The intent of this report is to focus on those processes and regulatory issues which have a direct bearing on existing and anticipated future management of transuranic (TRU) wastes from a commercial MOX fuel fabrication faciity. Recent government agency actions are reviewed with regard to their impact on existing and projected waste management regulations; and it is concluded that acceleration in the development of regulations, standards, and criteria is one of the most important factors in the implementation of improved MOX plant waste management techniques. ERDA development programs pertaining to the management of TRU wastes have been reviewed and many promising methods for volume reduction of both solid and liquid wastes are discussed. For solid wastes, these methods include compaction, shredding and baling, combustion, acid digestion, and decontamination by electropolishing or by electrolytic treatment. For liquid wastes, treatment options include evaporation, drying, calcination, flocculation, ion exchange, filtration, reverse osmosis, combustion (of combustible organics), and bioprocessing. Based on this review, it is recommended that ERDA continue with its combustible solid waste volume reduction program and complete these development activities by 1979. Following this, a critical evaluation of solid waste volume reduction techniques should be made to select the most promising systems for a commercial MOX fuel facility

  4. State-of-the-Art Report on Pilot Operated Safety Relief Valve

    International Nuclear Information System (INIS)

    Lee, Jun; Yoon, Ju Hyeon

    2003-12-01

    The pilot operated safety relief valve(POSRV) is a overpressure protection device. But the POSRV is additionally designed to be functioned as a fast depressurization device differently from the pressurizer safety valve(PSV). So, the POSRV assembly takes on the complicated configuration differently from the PSV, and also its configuration and component parts are much different according to its manufacturers. The objective of the study is to investigate the state of the art for POSRV. We want that the findings of the study are put to practical use as a selection guide to the utilities or system designers which want to purchase the POSRV. In this study, we selected the SEBIM and CCI made goods as the subject of investigation, and have investigated the technical characteristics and operating principles of the goods. However, in this report, the comparative contents with other company which were issued by one company were not handled. Also the advantages or disadvantages between two companies were not handled. Only the technical characteristics and operating principles with each company were described. For reference, the main considerations to select the POSRV' type are follows. - the characteristics of the system that the POSRV is to be installed - the fitness of the POSRV for the system - the requirements related to the function and operation of the POSRV - the vender's opinion

  5. Non-invasive techniques for measuring body composition: state of the art and future prospects

    Energy Technology Data Exchange (ETDEWEB)

    Cohn, S.H.

    1985-01-01

    In the past 20 years, in vivo analysis of body elements by neutron activation has become an important tool in medical research. In particular, it provides a much needed means to make quantitative assessments of body composition of human beings in vivo. The data are useful both for basic physiological understanding and for diagnosis and management of a variety of diseases and disorders. This paper traces the development of the in vivo neutron activation technique from basic systems to the present state of the art facilities. A scan of some of the numerous clinical applications that have been made with this technique, reveals the broad potentialities of in vivo neutron activation. The paper also considers alternative routes of future development and raises some of the questions now faced in making the techniques more widely available to both medical practitioners and medical investigators. In vivo neutron activation has opened a new era of both clinical diagnosis and therapy evaluation, and investigation into the modelling of body composition. The techniques are new, but it is already clear that considerable strides can be made in increasing accuracy and precision, increasing the number of elements susceptible to measurement, and reducing the dose required for the measurement. 18 refs., 7 figs.

  6. White biotechnology: State of the art strategies for the development of biocatalysts for biorefining.

    Science.gov (United States)

    Heux, S; Meynial-Salles, I; O'Donohue, M J; Dumon, C

    2015-12-01

    White biotechnology is a term that is now often used to describe the implementation of biotechnology in the industrial sphere. Biocatalysts (enzymes and microorganisms) are the key tools of white biotechnology, which is considered to be one of the key technological drivers for the growing bioeconomy. Biocatalysts are already present in sectors such as the chemical and agro-food industries, and are used to manufacture products as diverse as antibiotics, paper pulp, bread or advanced polymers. This review proposes an original and global overview of highly complementary fields of biotechnology at both enzyme and microorganism level. A certain number of state of the art approaches that are now being used to improve the industrial fitness of biocatalysts particularly focused on the biorefinery sector are presented. The first part deals with the technologies that underpin the development of industrial biocatalysts, notably the discovery of new enzymes and enzyme improvement using directed evolution techniques. The second part describes the toolbox available by the cell engineer to shape the metabolism of microorganisms. And finally the last part focuses on the 'omic' technologies that are vital for understanding and guide microbial engineering toward more efficient microbial biocatalysts. Altogether, these techniques and strategies will undoubtedly help to achieve the challenging task of developing consolidated bioprocessing (i.e. CBP) readily available for industrial purpose. Copyright © 2015 Elsevier Inc. All rights reserved.

  7. A state-of-the-art report on the development of liquid metal reactor materials

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Yung Suk; Noh, Kye Hoh; Han, Jung Hoh; Park, Jee Yun; Lee, Duk Hyun; Suh, Jung Hoon; Park, Kee Sung; Jung, Choong Hwan [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

    1993-09-01

    A state-of-the are survey on the LMR materials - core and structural materials and the others - has been conducted. For core materials, ferritic steels with superior swelling resistance such as HT-9 or PNC-FMS and the ODS steels are found to be one of the best candidates for the cladding and wrapper tubes, respectively. As boron carbide presently used for a neutron absorber also needs to extend its life time, much attention is now being paid to the development of a coated pellets and a kind of cermet made of boron carbide and metal in order to eliminate the control rod failure. As structural materials for pressure vessel, pipe and steam generator, the 316 MN SS with lower carbon and medium nitrogen compared to the 316 SS and 9Cr-1Mo ferritic steels are well recommended, respectively. The inelastic analytical model and the evaluation methodology to predict creep fatigue life time have been reviewed. On the other hand, a state of the art survey on the EMP coil/insulator materials has been conducted and the feasibility of the functionally gradient materials such as ZrO2-304 SS has also been investigated. 89 figs., 34 tabs., 131 refs. (Author).

  8. The geography of maternal and newborn health: the state of the art.

    Science.gov (United States)

    Ebener, Steeve; Guerra-Arias, Maria; Campbell, James; Tatem, Andrew J; Moran, Allisyn C; Amoako Johnson, Fiifi; Fogstad, Helga; Stenberg, Karin; Neal, Sarah; Bailey, Patricia; Porter, Reid; Matthews, Zoe

    2015-05-27

    As the deadline for the millennium development goals approaches, it has become clear that the goals linked to maternal and newborn health are the least likely to be achieved by 2015. It is therefore critical to ensure that all possible data, tools and methods are fully exploited to help address this gap. Among the methods that are under-used, mapping has always represented a powerful way to 'tell the story' of a health problem in an easily understood way. In addition to this, the advanced analytical methods and models now being embedded into Geographic Information Systems allow a more in-depth analysis of the causes behind adverse maternal and newborn health (MNH) outcomes. This paper examines the current state of the art in mapping the geography of MNH as a starting point to unleashing the potential of these under-used approaches. Using a rapid literature review and the description of the work currently in progress, this paper allows the identification of methods in use and describes a framework for methodological approaches to inform improved decision-making. The paper is aimed at health metrics and geography of health specialists, the MNH community, as well as policy-makers in developing countries and international donor agencies.

  9. State of the art on power performance assessments for wind energy conversion systems

    Energy Technology Data Exchange (ETDEWEB)

    Maribo Pedersen, B. [ed.

    1997-12-31

    It is the intention of this meeting to clarify the status of power performance verification and assessment and identify the future needs in terms of applications, research fields and standardization actions, putting emphasis on the following items: Power performance verification for wind farms; Power performance verification for large wind turbines; Power performance verification for wind turbines operating in complex terrain; Assessment of the available international and national standards; Assessment of developed, applied and verified tools for WECS power performance. This Experts Meeting had gathered 14 participants from 6 different countries. 12 presentations were given and although countries with a sizeable wind program, ie. Italy, UK and Spain were not present, it is felt that the meeting gave a fair impression of the contemporary state of the art world wide. Specific problems concerning accurate definition and measurement of wind speed by cup-anemometers were dealt with. Different sources of errors were analysed and valuable new experimental results were presented. Other instruments for wind-speed measurements than cup-anemometers were discussed as well. (EG)

  10. State of the art and new developments in molecular diagnostics for hemoglobinopathies in multiethnic societies.

    Science.gov (United States)

    Harteveld, C L

    2014-02-01

    For detecting carriers of thalassemia traits, the basic part of diagnostics consists of measurement of the hematological indices followed by mostly automatic separation and measurement of the Hb fractions, while direct Hb separation either on high pressure liquid chromatography or capillary electrophoresis is sufficient to putatively identify carriers of the common Hb variants like HbS, C, E, D, and O-Arab. A putative positive result is reported together with an advice for parents, partner, or family analysis. For couples, presumed at-risk confirmation at the DNA level is essential. In general, this part of diagnostics is done in specialized centers provided with sufficient experience and the technical tools needed to combine hematological and biochemical interpretation with identification of the mutations at the molecular level. State-of-the-art tools are usually available in centers that also provide prenatal diagnosis and should consist of gap-PCR for the common deletions, direct DNA sequencing for all kind of point-mutations and the capacity to uncover novel or rare mutations or disease mechanisms. New developments are MLPA for large and eventually unknown deletion defects and microarray technology for fine mapping and primer design for breakpoint analysis. Gap-PCR primers designed in the region flanking the deletion breakpoints can subsequently be used to facilitate carrier detection of uncommon deletions in family members or isolated populations in laboratories where no microarray technology or MLPA is available. © 2013 John Wiley & Sons Ltd.

  11. Non-invasive techniques for measuring body composition: state of the art and future prospects

    International Nuclear Information System (INIS)

    Cohn, S.H.

    1985-01-01

    In the past 20 years, in vivo analysis of body elements by neutron activation has become an important tool in medical research. In particular, it provides a much needed means to make quantitative assessments of body composition of human beings in vivo. The data are useful both for basic physiological understanding and for diagnosis and management of a variety of diseases and disorders. This paper traces the development of the in vivo neutron activation technique from basic systems to the present state of the art facilities. A scan of some of the numerous clinical applications that have been made with this technique, reveals the broad potentialities of in vivo neutron activation. The paper also considers alternative routes of future development and raises some of the questions now faced in making the techniques more widely available to both medical practitioners and medical investigators. In vivo neutron activation has opened a new era of both clinical diagnosis and therapy evaluation, and investigation into the modelling of body composition. The techniques are new, but it is already clear that considerable strides can be made in increasing accuracy and precision, increasing the number of elements susceptible to measurement, and reducing the dose required for the measurement. 18 refs., 7 figs

  12. A state-of-the-art report on the formulation and characterization of synroc

    International Nuclear Information System (INIS)

    Jung, C. H.; Park, J. Y.; Oh, S. J.; Kim, H. Y.; Kim, I. T.

    1998-09-01

    Synroc (Synthetic Rock), a titanate-based ceramic originally proposed by Prof. A. Ringwood (ANU) and designed for the immobilization of high level nuclear waste (HLW), consists of three principal phases such as hollandite, zirconolite and perovskite. Nearly all the fission products and actinides in HLW can be incorporated as solid-solution in at least one of these phase. The preferred form of Synroc can be obtained up to 20 % of high level waste calcine to form dilute solid solution. The constituent minerals, or close structural analogues, have survived in a wide range of geochemical environments for periods of 20-2000 Myr while immobilizing the same elements present in nuclear waste. A dense, compact, and mechanically strong form of Synroc can be formed by hot pressing reactive precursor powders at about 1200 dg C and 20 MPa. In this state-of-the-art report, formulation method and characterization of Syroc with respect to the crystal structure, the consisting substances, types, etc. were reviewed. Additionally, a new promising powder process, C ombustion Process , was proposed and the properties of the combustion-synthesized powder were described. An international cooperative program between JAERI and ANSTO, and US patents for early Synroc research in Australia were also introduced. From the literatures review, Synroc is expected to have advantages in using as an immobilizer of HLW. Therefore, a systematic research to develop the Synroc is needed. (author). 53 refs., 2 tabs., 16 figs

  13. State of the art and the dark side of amyotrophic lateral sclerosis

    Institute of Scientific and Technical Information of China (English)

    Antonio; Musarò

    2010-01-01

    Amyotrophic lateral sclerosis(ALS) is a disorder that involves the degeneration of motor neurons,muscle atrophy,and paralysis.In a few familiar forms of ALS,mutations in the superoxide dismutase-1(SOD1) gene have been held responsible for the degeneration of motor neurons.Nevertheless,after the discovery of the SOD1 mutations no consensus has emerged as to which cells,tissues and pathways are primarily implicated in the pathogenic events that lead to ALS.Ubiquitous overexpression of mutant SOD1 in transgenic animals recapitulates the pathological features of ALS.However,the toxicity of mutant SOD1 is not necessarily limited to the central nervous system.Views about ALS pathogenesis are now enriched by the recent discovery of mutations in a pair of DNA/RNA-binding proteins called TDP-43 and FUS/TLS as causes of familial and sporadic forms of ALS.Although the steps that lead to the pathological state are well defined,several fundamental issues are still controversial:are the motor neurons the first direct targets of ALS;and what is the contribution of non-neuronal cells,if any,to the pathogenesis of ALS?The state of the art of ALS pathogenesis and the open questions are discussed in this review.

  14. A State-of-the-Art Review: Personalization of Tinnitus Sound Therapy.

    Science.gov (United States)

    Searchfield, Grant D; Durai, Mithila; Linford, Tania

    2017-01-01

    Background: There are several established, and an increasing number of putative, therapies using sound to treat tinnitus. There appear to be few guidelines for sound therapy selection and application. Aim: To review current approaches to personalizing sound therapy for tinnitus. Methods: A "state-of-the-art" review (Grant and Booth, 2009) was undertaken to answer the question: how do current sound-based therapies for tinnitus adjust for tinnitus heterogeneity? Scopus, Google Scholar, Embase and PubMed were searched for the 10-year period 2006-2016. The search strategy used the following key words: "tinnitus" AND "sound" AND "therapy" AND "guidelines" OR "personalized" OR "customized" OR "individual" OR "questionnaire" OR "selection." The results of the review were cataloged and organized into themes. Results: In total 165 articles were reviewed in full, 83 contained sufficient details to contribute to answering the study question. The key themes identified were hearing compensation, pitched-match therapy, maskability, reaction to sound and psychosocial factors. Although many therapies mentioned customization, few could be classified as being personalized. Several psychoacoustic and questionnaire-based methods for assisting treatment selection were identified. Conclusions: Assessment methods are available to assist clinicians to personalize sound-therapy and empower patients to be active in therapy decision-making. Most current therapies are modified using only one characteristic of the individual and/or their tinnitus.

  15. Microbiological Surveillance and State of the Art Technological Strategies for the Prevention of Dialysis Water Pollution

    Directory of Open Access Journals (Sweden)

    Andrea Galfrè

    2012-08-01

    Full Text Available Methods: The present report attempts to illustrate the positive impact on the microbiological quality of dialysis patients over a 15-year period through the progressive implementation of state-of-the-art technological strategies and the optimization of microbiological surveillance procedures in five dialysis units in Sardinia. Results: Following on better microbiological, quality controls of dialysis water and improvement of procedures and equipment, a drastic improvement of microbiological water quality was observed in a total of 945 samples. The main aim was to introduce the use of microbiological culture methods as recommended by the most important guidelines. The microbiological results obtained have led to a progressive refining of controls and introduction of new materials and equipment, including two-stage osmosis and piping distribution rings featuring a greater capacity to prevent biofilm adhesion. The actions undertaken have resulted in unexpected quality improvements. Conclusions: Dialysis water should be viewed by the nephrologist as a medicinal product exerting a demonstrable positive impact on microinflammation in dialysis patients. A synergic effort between nephrologists and microbiologists undoubtedly constitutes the most effective means of preventing dialysis infections.

  16. u-Healthcare system: state-of-the-art review and challenges.

    Science.gov (United States)

    Touati, Farid; Tabish, Rohan

    2013-06-01

    With the increase of an ageing population and chronic diseases, society becomes more health conscious and patients become "health consumers" looking for better health management. People's perception is shifting towards patient-centered, rather than the classical, hospital-centered health services which has been propelling the evolution of telemedicine research from the classic e-Health to m-Health and now is to ubiquitous healthcare (u-Health). It is expected that mobile & ubiquitous Telemedicine, integrated with Wireless Body Area Network (WBAN), have a great potential in fostering the provision of next-generation u-Health. Despite the recent efforts and achievements, current u-Health proposed solutions still suffer from shortcomings hampering their adoption today. This paper presents a comprehensive review of up-to-date requirements in hardware, communication, and computing for next-generation u-Health systems. It compares new technological and technical trends and discusses how they address expected u-Health requirements. A thorough survey on various worldwide recent system implementations is presented in an attempt to identify shortcomings in state-of-the art solutions. In particular, challenges in WBAN and ubiquitous computing were emphasized. The purpose of this survey is not only to help beginners with a holistic approach toward understanding u-Health systems but also present to researchers new technological trends and design challenges they have to cope with, while designing such systems.

  17. Passive Optical Access Networks: State of the Art and Future Evolution

    Directory of Open Access Journals (Sweden)

    Tommaso Muciaccia

    2014-10-01

    Full Text Available In the very last years, optical access networks are growing very rapidly, from both the network operators and the research interests points of view. Fiber To The Home (FTTH is already a reality in plenty of real contexts and there has been a further stimulus to the proposal of new solutions and the investigation of new possibilities, in order to optimize network performance and reduce capital and operational expenditure. A complete and systematic overview of passive optical access networks is presented in this paper, concerning both the hot research topics and the main operative issues about the design guidelines and the deployment of Passive Optical Networks (PON architectures, nowadays the most commonly implemented approach to realize optical fiber links in the access networks. A comparison of advantages and disadvantages of different multiplexing techniques is discussed, with specific reference to WDM-based networks, almost universally considered as the enabling technology for future proof bandwidth requirements. An exhaustive summary is also given about the-state-of-the-art of modulation and encoding techniques recently proposed by the scientific community, as well as the open challenges (such as colorless and coolerless ONUs for telecom companies and international standardization compliance.

  18. Myoelectric control of prosthetic hands: state-of-the-art review

    Directory of Open Access Journals (Sweden)

    Geethanjali P

    2016-07-01

    Full Text Available Purushothaman Geethanjali School of Electrical Engineering Department of Control and Automation VIT University, Vellore, Tamil Nadu, India Abstract: Myoelectric signals (MES have been used in various applications, in particular, for identification of user intention to potentially control assistive devices for amputees, orthotic devices, and exoskeleton in order to augment capability of the user. MES are also used to estimate force and, hence, torque to actuate the assistive device. The application of MES is not limited to assistive devices, and they also find potential applications in teleoperation of robots, haptic devices, virtual reality, and so on. The myoelectric control-based prosthetic hand aids to restore activities of daily living of amputees in order to improve the self-esteem of the user. All myoelectric control-based prosthetic hands may not have similar operations and exhibit variation in sensing input, deciphering the signals, and actuating prosthetic hand. Researchers are focusing on improving the functionality of prosthetic hand in order to suit the user requirement with the different operating features. The myoelectric control differs in operation to accommodate various external factors. This article reviews the state of the art of myoelectric prosthetic hand, giving description of each control strategy. Keywords: EMG, assistive device, amputee, myoelectric control, electric powered, body ­powered, bioelectric signal control

  19. Non-invasive brain stimulation of the aging brain: State of the art and future perspectives.

    Science.gov (United States)

    Tatti, Elisa; Rossi, Simone; Innocenti, Iglis; Rossi, Alessandro; Santarnecchi, Emiliano

    2016-08-01

    Favored by increased life expectancy and reduced birth rate, worldwide demography is rapidly shifting to older ages. The golden age of aging is not only an achievement but also a big challenge because of the load of the elderly on social and medical health care systems. Moreover, the impact of age-related decline of attention, memory, reasoning and executive functions on self-sufficiency emphasizes the need of interventions to maintain cognitive abilities at a useful degree in old age. Recently, neuroscientific research explored the chance to apply Non-Invasive Brain Stimulation (NiBS) techniques (as transcranial electrical and magnetic stimulation) to healthy aging population to preserve or enhance physiologically-declining cognitive functions. The present review will update and address the current state of the art on NiBS in healthy aging. Feasibility of NiBS techniques will be discussed in light of recent neuroimaging (either structural or functional) and neurophysiological models proposed to explain neural substrates of the physiologically aging brain. Further, the chance to design multidisciplinary interventions to maximize the efficacy of NiBS techniques will be introduced as a necessary future direction. Copyright © 2016 Elsevier B.V. All rights reserved.

  20. Processing and Analysis of Multichannel Extracellular Neuronal Signals: State-of-the-art and Challenges

    Directory of Open Access Journals (Sweden)

    Mufti eMahmud

    2016-06-01

    Full Text Available In recent years multichannel neuronal signal acquisition systems have allowed scientists to focus on research questions which were otherwise impossible. They act as a powerful means to study brain (dysfunctions in in-vivo and in in-vitro animal models. Typically, each session of electrophysiological experiments with multichannel data acquisition systems generate large amount of raw data. For example, a 128 channel signal acquisition system with 16 bits A/D conversion and 20 kHz sampling rate will generate approximately 17 GB data per hour (uncompressed. This poses an important and challenging problem of inferring conclusions from the large amounts of acquired data. Thus, automated signal processing and analysis tools are becoming a key component in neuroscience research, facilitating extraction of relevant information from neuronal recordings in a reasonable time. The purpose of this review is to introduce the reader to the current state-of-the-art of open-source packages for (semiautomated processing and analysis of multichannel extracellular neuronal signals (i.e., neuronal spikes, local field potentials, electroencephalogram, etc., and the existing Neuroinformatics infrastructure for tool and data sharing. The review is concluded by pinpointing some major challenges that are to be faced, which include the development of novel benchmarking techniques, cloud-based distributed processing and analysis tools, as well as defining novel means to share and standardize data.

  1. West Nile Virus State of the Art Report of MALWEST Project

    Directory of Open Access Journals (Sweden)

    Andriani Marka

    2013-12-01

    Full Text Available During the last three years Greece is experiencing the emergence of West Nile virus (WNV epidemics. Within this framework, an integrated surveillance and control programme (MALWEST project with thirteen associate partners was launched aiming to investigate the disease and suggest appropriate interventions. One out of seven work packages of the project is dedicated to the State of the Art report for WNV. Three expert working groups on humans, animals and mosquitoes were established. Medical databases (PubMed, Scopus were searched together with websites: e.g., WHO, CDC, ECDC. In total, 1,092 relevant articles were initially identified and 258 of them were finally included as references regarding the current knowledge about WNV, along with 36 additional sources (conference papers, reports, book chapters. The review is divided in three sections according to the fields of interest: (1 WNV in humans (epidemiology, molecular characteristics, transmission, diagnosis, treatment, prevention, surveillance; (2 WNV in animals (epidemiological and transmission characteristics concerning birds, horses, reptiles and other animal species and (3 WNV in mosquitoes (control, surveillance. Finally, some examples of integrated surveillance programmes are presented. The introduction and establishment of the disease in Greece and other European countries further emphasizes the need for thorough research and broadening of our knowledge on this viral pathogen.

  2. Glucocorticoids at the Olympic Games: state-of-the-art review.

    Science.gov (United States)

    Fitch, Ken

    2016-10-01

    In this state-of-the-art review, the author discusses the history of prohibiting glucocorticoids (GCs) and how this has occurred over nearly three decades at the Olympic Games. He relates how prohibiting systemic GCs in sport was a major factor in the development of therapeutic use exemptions and the fluctuating status of non-systemic GCs (banned, not banned). Concern is expressed that for 2017, the World Anti-Doping Agency (WADA) is proposing to prohibit injecting GCs shortly prior to competition. The author notes that in 1986, when GCs were first prohibited, analytical chemistry techniques could not distinguish the route of GC administration from its urinary concentration. Thirty years later, this remains the case. Importantly, this article discusses how the desired pharmacological effects of injecting GCs locally and intra-articularly can be achieved and why exercising vigorously immediately or shortly after a GC injection is therapeutically unsound. The review concludes by agreeing that injecting GCs shortly prior to strenuous training or competition is medically unwise but stresses that this is a clinical matter that sport-not WADA-needs to address. Cycling and rowing have managed this successfully for the past 5 years. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  3. Salter-Harris type II proximal humerus injuries: state-of-the-art treatment.

    Science.gov (United States)

    Verdano, Michele Arcangelo; Pellegrini, Andrea; Lunini, Enricomaria; Porcellini, Giuseppe; Ceccarelli, Francesco

    2012-12-01

    Proximal epiphyseal injuries of the humerus represent a very low percentage of traumatic growth pathologies, 5 % of all fractures during childhood. In the literature, there have been only a limited number of clinical studies investigating these injuries, basically from an epidemiological point of view, focusing on the incidence of the different types of fractures. We report our experience of 6 young patients with Salter-Harris type II proximal humerus epiphyseal injuries adopting a minimally invasive surgical technique consisting of closed reduction and percutaneous fixation with Kirschner wires. At 2 years of follow-up, the results consisting in constant; disabilities of the arm, shoulder, and hand; simple shoulder test; and Visual Analogue Scale scores obtained have been excellent and all the patients come back to a normal life with sports practice and normal daily activities. The range of motion was completely restored without any deficit in abduction-adduction, flection-extension, or intra-extra rotation. No differences in anthropometric parameters were found with no case of malangulation, vascular, or neurological complications. Our data support with evidence how the close reduction internal fixation with K-wires treatment can give to the surgeons and the patients a better security about the correct fracture healing. Furthermore, with this article, we will provide a detailed review of the literature in order to define the state-of-the-art treatment to better face such a challenging skeletal injury.

  4. Moving Towards a State of the Art Charge-Exchange Reaction Code

    Science.gov (United States)

    Poxon-Pearson, Terri; Nunes, Filomena; Potel, Gregory

    2017-09-01

    Charge-exchange reactions have a wide range of applications, including late stellar evolution, constraining the matrix elements for neutrinoless double β-decay, and exploring symmetry energy and other aspects of exotic nuclear matter. Still, much of the reaction theory needed to describe these transitions is underdeveloped and relies on assumptions and simplifications that are often extended outside of their region of validity. In this work, we have begun to move towards a state of the art charge-exchange reaction code. As a first step, we focus on Fermi transitions using a Lane potential in a few body, Distorted Wave Born Approximation (DWBA) framework. We have focused on maintaining a modular structure for the code so we can later incorporate complications such as nonlocality, breakup, and microscopic inputs. Results using this new charge-exchange code will be shown compared to the analysis in for the case of 48Ca(p,n)48Sc. This work was supported in part by the National Nuclear Security Administration under the Stewardship Science Academic Alliances program through the U.S. DOE Cooperative Agreement No. DE- FG52-08NA2855.

  5. Catalytic Reforming of Oxygenates: State of the Art and Future Prospects.

    Science.gov (United States)

    Li, Di; Li, Xinyu; Gong, Jinlong

    2016-10-12

    This Review describes recent advances in the design, synthesis, reactivity, selectivity, structural, and electronic properties of the catalysts for reforming of a variety of oxygenates (e.g., from simple monoalcohols to higher polyols, then to sugars, phenols, and finally complicated mixtures like bio-oil). A comprehensive exploration of the structure-activity relationship in catalytic reforming of oxygenates is carried out, assisted by state-of-the-art characterization techniques and computational tools. Critical emphasis has been given on the mechanisms of these heterogeneous-catalyzed reactions and especially on the nature of the active catalytic sites and reaction pathways. Similarities and differences (reaction mechanisms, design and synthesis of catalysts, as well as catalytic systems) in the reforming process of these oxygenates will also be discussed. A critical overview is then provided regarding the challenges and opportunities for research in this area with a focus on the roles that systems of heterogeneous catalysis, reaction engineering, and materials science can play in the near future. This Review aims to present insights into the intrinsic mechanism involved in catalytic reforming and provides guidance to the development of novel catalysts and processes for the efficient utilization of oxygenates for energy and environmental purposes.

  6. Robotic-Assisted Unicompartmental Knee Arthroplasty: State-of-the Art and Review of the Literature.

    Science.gov (United States)

    Christ, Alexander B; Pearle, Andrew D; Mayman, David J; Haas, Steven B

    2018-03-16

    Unicompartmental knee arthroplasty is a successful treatment for unicompartmental knee osteoarthritis that has lower complication rates, faster recovery, and a more natural feeling knee compared to total knee arthroplasty. However, long-term survival has been a persistent concern. As more surgeon-controlled variables have been linked to survival, interest in robotic-assisted surgery has continued to grow. A review and synthesis of the literature on the subject of robotic-assisted unicompartmental knee arthroplasty was performed. We present the driving factors behind the development of robotic-assisted techniques in unicompartmental knee arthroplasty and the current state-of-the art. The ability of surgeons to achieve intraoperative targets with robotic assistance and the outcomes of robotic-assisted surgery are also described. Robotic-assisted surgery has become increasingly popular in unicompartmental knee arthroplasty, as it allows surgeons to more accurately and reproducibly plan and achieve operative targets during surgery. Cost remains a concern, and it remains to be seen whether robotic-assisted surgery will improve long-term survivorship after unicompartmental knee arthroplasty. Copyright © 2018 Elsevier Inc. All rights reserved.

  7. Laboratory diagnosis of Lyme borreliosis: Current state of the art and future perspectives.

    Science.gov (United States)

    Lohr, Benedikt; Fingerle, Volker; Norris, Douglas E; Hunfeld, Klaus-Peter

    2018-06-01

    This review is directed at physicians and laboratory personnel in private practice and clinics who treat and diagnose Lyme borreliosis (LB) in patients as part of their daily work. A major objective of this paper is to bring together background information on Borrelia (B.) burgdorferi sensu lato (s.l.) and basic clinical knowledge of LB, which is one of the most frequently reported vector-borne diseases in the Northern Hemisphere. The goal is to provide practical guidance for clinicians and for laboratory physicians, and scientists for a better understanding of current achievements and ongoing obstacles in the laboratory diagnosis of LB, an infectious disease that still remains one of the diagnostic chameleons of modern clinical medicine. Moreover, in bringing together current scientific information from guidelines, reviews, and original papers, this review provides recommendations for selecting the appropriate tests in relation to the patient's stage of disease to achieve effective, stage-related application of current direct and indirect laboratory methods for the detection of B. burgdorferi s.l. Additionally, the review aims to discuss the current state of the art concerning the diagnostic potential and limitations of the assays and test methods currently in use to optimize LB patient management and provide insight into the possible future prospects of this rapidly changing area of laboratory medicine.

  8. Implementing Reliability Centered Maintenance (RCM) with State of the Art PT&I Technologies

    Science.gov (United States)

    Hollis, Sean; Sasser, Chase

    2016-01-01

    Building on the work that was started two decades ago, Jacobs Space Operations Group has utilized state of the art PTI technologies to assess the current condition of the assets they manage under the Test and Operations Support Contract (TOSC). Specifically, the Asset Management department leveraged the benefits of ultrasound technology to quantify a motor issue in the Liquid Oxygen Storage Area, and troubleshoot the sources prior to loading the tank to perform Verification and Validation (VV) activities. This technology was efficient, easy to implement, and provided system engineers with data on a possible source of the problem. In situations where legacy motors are exhibiting unexpected noises, it may seem easier to remove and refurbish the motor and replace the bearings because that solution resolves most of the common causes of the noise. However, that solution would have involved additional spending and may not have solved issues stemming from the foundation, if those existed. By utilizing the ultrasound equipment provided by UE Systems, the sound profiles allowed Jacobs TOSC team to determine that the issue resembled a faulty bearing. After replacing the bearing, the unexpected noise ceased.

  9. [State-of-the-art status on airborne antibiotic resistant bacteria and antibiotic resistance genes].

    Science.gov (United States)

    Li, J; Yao, M S

    2018-04-06

    The world is facing more deaths due to increasing antibiotic-resistant bacterial infections and the shortage of new highly effective antibiotics, however the air media as its important transmission route has not been adequately studied. Based on the latest literature acquired in this work, we have discussed the state-of-the-art research progress of the concentration, distribution and spread of antibiotic resistant bacteria (ARB) and antibiotic resistance genes (ARGs) in different environmental air media, and also analyzed some future prevention and control measures. The large use of antibiotics in the medical settings and animal husbandry places has resulted in higher abundances of ARB and ARGs in the relevant and surrounding atmosphere than in urban and general indoor air environments. ARGs can be spread by adhering to airborne particles, and researchers have also found that air media contain more abundant ARGs than other environmental media such as soil, water and sediment. It was suggested in this review that strengthening the monitoring, study on spreading factors and biological toxicity, and also research and development on pathogen accurate diagnosis and new green antibiotic are expected to help effectively monitor, prevent and control of the impacts of airborne resistant bacteria and resistance genes on both human and ecologies.

  10. Comparative study of state-of-the-art myoelectric controllers for multigrasp prosthetic hands.

    Science.gov (United States)

    Segil, Jacob L; Controzzi, Marco; Weir, Richard F ff; Cipriani, Christian

    2014-01-01

    A myoelectric controller should provide an intuitive and effective human-machine interface that deciphers user intent in real-time and is robust enough to operate in daily life. Many myoelectric control architectures have been developed, including pattern recognition systems, finite state machines, and more recently, postural control schemes. Here, we present a comparative study of two types of finite state machines and a postural control scheme using both virtual and physical assessment procedures with seven nondisabled subjects. The Southampton Hand Assessment Procedure (SHAP) was used in order to compare the effectiveness of the controllers during activities of daily living using a multigrasp artificial hand. Also, a virtual hand posture matching task was used to compare the controllers when reproducing six target postures. The performance when using the postural control scheme was significantly better (p state machines during the physical assessment when comparing within-subject averages using the SHAP percent difference metric. The virtual assessment results described significantly greater completion rates (97% and 99%) for the finite state machines, but the movement time tended to be faster (2.7 s) for the postural control scheme. Our results substantiate that postural control schemes rival other state-of-the-art myoelectric controllers.

  11. Attractive PHHP interactions revealed by state-of-the-art ab initio calculations.

    Science.gov (United States)

    Yourdkhani, Sirous; Jabłoński, Mirosław; Echeverría, Jorge

    2017-10-25

    We report in this work a combined structural and state-of-the-art computational study of homopolar P-HH-P intermolecular contacts. Database surveys have shown the abundance of such surprisingly unexplored contacts, which are usually accompanied by other weak interactions in the solid state. By means of a detailed theoretical study utilizing SAPT(DFT), MP2, SCS-MP2, MP2C and CCSD(T) methods and both aug-cc-pVXZ and aug-cc-pCVXZ (X = D, T, Q, 5) basis sets as well as extrapolation to the CBS limit, we have shown that P-HH-P contacts are indeed attractive and considerably strong. SAPT(DFT) calculations have revealed the dispersive nature of the P-HH-P interaction with only minor contribution of the inductive term, whereas the first-order electrostatic term is clearly overbalanced by the first-order exchange energy. In general the computed interaction energies follow the trend: E ≈ E < E < E. Our results have also shown that the aug-cc-pVDZ (or aug-cc-pCVDZ) basis set is not yet well balanced and that the second-order dispersion energy term is the slowest converging among all SAPT(DFT) energy components. Compared to aug-cc-pVXZ basis sets, their core-correlation counterparts have a modest influence on all supermolecular interaction energies and a negligible influence on both the SAPT(DFT) interaction energy and its components.

  12. State-of-the-Art Techniques in Treating Peripheral Nerve Injury.

    Science.gov (United States)

    Kubiak, Carrie A; Kung, Theodore A; Brown, David L; Cederna, Paul S; Kemp, Stephen W P

    2018-03-01

    Peripheral nerve injuries remain a major clinical concern, as they often lead to chronic disability and significant health care expenditures. Despite advancements in microsurgical techniques to enhance nerve repair, biological approaches are needed to augment nerve regeneration and improve functional outcomes after injury. Presented herein is a review of the current literature on state-of-the-art techniques to enhance functional recovery for patients with nerve injury. Four categories are considered: (1) electroceuticals, (2) nerve guidance conduits, (3) fat grafting, and (4) optogenetics. Significant study results are highlighted, focusing on histologic and functional outcome measures. This review documents the current state of the literature. Advancements in neuronal stimulation, tissue engineering, and cell-based therapies demonstrate promise with regard to augmenting nerve regeneration and appropriate rehabilitation. The future of treating peripheral nerve injury will include multimodality use of electroconductive conduits, fat grafting, neuronal stimulation, and optogenetics. Further clinical investigation is needed to confirm the efficacy of these technologies on peripheral nerve recovery in humans, and how best to implement this treatment for a diverse population of nerve-injured patients.

  13. SSAT State-of-the-Art Conference: Current Surgical Management of Gastric Tumors.

    Science.gov (United States)

    Norton, Jeffrey A; Kim, Teresa; Kim, Joseph; McCarter, Martin D; Kelly, Kaitlyn J; Wong, Joyce; Sicklick, Jason K

    2018-01-01

    The current era of gastric surgery is marked by low morbidity and mortality rates, innovative strategies to approach resections with a minimally invasive fashion or hyperthermic intraperitoneal chemotherapy (HIPEC), as well as improved understanding of the biology of sporadic and hereditary stromal, neuroendocrine, and epithelial malignancies. In 2017, the Society for Surgery of the Alimentary Tract convened a State-of-the-Art Conference on Current Surgical Management of Gastric Tumors with both international experts and emerging leaders in the field of gastric surgery. Martin D. McCarter, MD of the University of Colorado discussed the current management of gastric gastrointestinal stromal tumors (GIST). Kaitlyn J. Kelly, MD of the University of California, San Diego discussed the management of gastric carcinoid tumors. Jeffrey A. Norton of Stanford University discussed recent advances in the management of gastric adenocarcinoma including a focus on hereditary diffuse gastric cancer (HDGC). Joseph Kim, MD of Stony Brook University discussed a systematic approach to minimally invasive gastrectomy for cancer. Joyce Wong, MD of Pennsylvania State University discussed the role for cytoreductive surgery (CRS) and HIPEC for gastric adenocarcinoma. This review provides gastrointestinal surgeons with a concise update on the current surgical management of gastric tumors.

  14. Congenital pulmonary airway malformations: state-of-the-art review for pediatrician's use.

    Science.gov (United States)

    Leblanc, Claire; Baron, Marguerite; Desselas, Emilie; Phan, Minh Hanh; Rybak, Alexis; Thouvenin, Guillaume; Lauby, Clara; Irtan, Sabine

    2017-12-01

    Congenital pulmonary airway malformations or CPAM are rare developmental lung malformations, leading to cystic and/or adenomatous pulmonary areas. Nowadays, CPAM are diagnosed prenatally, improving the prenatal and immediate postnatal care and ultimately the knowledge on CPAM pathophysiology. CPAM natural evolution can lead to infections or malignancies, whose exact prevalence is still difficult to assess. The aim of this "state-of-the-art" review is to cover the recently published literature on CPAM management whether the pulmonary lesion was detected during pregnancy or after birth, the current indications of surgery or surveillance and finally its potential evolution to pleuro-pulmonary blastoma. Surgery remains the cornerstone treatment of symptomatic lesions but the postnatal management of asymptomatic CPAM remains controversial. There are pros and cons of surgical resection, as increasing rate of infections over time renders the surgery more difficult after months or years of evolution, as well as risk of malignancy, though exact incidence is still unknown. What is known: • Congenital pulmonary airway malformations (CPAM) are rare developmental lung malformations mainly antenatally diagnosed. • While the neonatal management of symptomatic CPAM is clear and includes prompt surgery, controversies remain for asymptomatic CPAM due to risk of infections and malignancies. What is new: • Increased rate of infection over time renders the surgery more difficult after months or years of evolution and pushes for recommendation of early elective surgery. • New molecular or pathological pathways may help in the distinction of type 4 CPAM from type I pleuropulmonary blastoma.

  15. Stochastic programming the state of the art in honor of George B. Dantzig

    CERN Document Server

    2011-01-01

    From the Preface… The preparation of this book started in 2004, when George B. Dantzig and I, following a long-standing invitation by Fred Hillier to contribute a volume to his International Series in Operations Research and Management Science, decided finally to go ahead with editing a volume on stochastic programming. The field of stochastic programming (also referred to as optimization under uncertainty or planning under uncertainty) had advanced significantly in the last two decades, both theoretically and in practice. George Dantzig and I felt that it would be valuable to showcase some of these advances and to present what one might call the state-of- the-art of the field to a broader audience. We invited researchers whom we considered to be leading experts in various specialties of the field, including a few representatives of promising developments in the making, to write a chapter for the volume. Unfortunately, to the great loss of all of us, George Dantzig passed away on May 13, 2005. Encouraged by...

  16. State of the Art and Recent Research Advances in Software Defined Networking

    Directory of Open Access Journals (Sweden)

    Taimur Bakhshi

    2017-01-01

    Full Text Available Emerging network services and subsequent growth in the networking infrastructure have gained tremendous momentum in recent years. Application performance requiring rapid real-time network provisioning, optimized traffic management, and virtualization of shared resources has induced the conceptualization and adoption of new networking models. Software defined networking (SDN, one of the predominant and relatively new networking paradigms, seeks to simplify network management by decoupling network control logic from the underlying hardware and introduces real-time network programmability enabling innovation. The present work reviews the state of the art in software defined networking providing a historical perspective on complementary technologies in network programmability and the inherent shortcomings which paved the way for SDN. The SDN architecture is discussed along with popular protocols, platforms, and existing simulation and debugging solutions. Furthermore, a detailed analysis is presented around recent SDN development and deployment avenues ranging from mobile communications and data centers to campus networks and residential environments. The review concludes by highlighting implementation challenges and subsequent research directions being pursued in academia and industry to address issues related to application performance, control plane scalability and design, security, and interdomain connectivity in the context of SDN.

  17. State of the Art Study on Aging of Asphalt Mixtures and Use of Antioxidant Additives

    Directory of Open Access Journals (Sweden)

    Okan Sirin

    2018-01-01

    Full Text Available The detrimental effects of hardening in asphalt pavements were first recognized by pioneering pavement engineers in the 1900s and have been studied extensively during the last 70 years. This hardening process, referred to as asphalt aging, is generally defined as change in the rheological properties of asphalt binders/mixtures due to changes in chemical composition during construction and its service life period. Aging causes the asphalt material to stiffen and embrittle, which affects the durability and leads to a high potential for cracking. This paper presents the state of the art on asphalt and asphalt mixture aging and use of antioxidant additives to retard the aging. A picture of complex molecular structure of asphalt and its changes due to atmospheric condition and various protocols used to simulate aging in laboratory environment are also discussed. Emphasis is given on recent studies on simulation of aging of asphalt mixtures as there has been limited research on mixtures compared to the asphalt binder. Finally, this paper presents the application of antiaging techniques and its mechanism, use of various types of antioxidant additives to retard aging of asphalt and, hence, improve the performance of asphalt pavements.

  18. Immunosuppression for in vivo research: state-of-the-art protocols and experimental approaches

    Institute of Scientific and Technical Information of China (English)

    Rita Diehl; Fabienne Ferrara; Claudia Müller; Antje Y Dreyer; Damian D McLeod; Stephan Fricke; Johannes Boltze

    2017-01-01

    Almost every experimental treatment strategy using non-autologous cell,tissue or organ transplantation is tested in small and large animal models before clinical translation.Because these strategies require immunosuppression in most cases,immunosuppressive protocols are a key element in transplantation experiments.However,standard immunosuppressive protocols are often applied without detailed knowledge regarding their efficacy within the particular experimental setting and in the chosen model species.Optimization of such protocols is pertinent to the translation of experimental results to human patients and thus warrants further investigation.This review summarizes current knowledge regarding immunosuppressive drug classes as well as their dosages and application regimens with consideration of species-specific drug metabolization and side effects.It also summarizes contemporary knowledge of novel immunomodulatory strategies,such as the use of mesenchymal stem cells or antibodies.Thus,this review is intended to serve as a state-of-the-art compendium for researchers to refine applied experimental immunosuppression and immunomodulation strategies to enhance the predictive value of preclinical transplantation studies.

  19. Review: Semen sexing - current state of the art with emphasis on bovine species.

    Science.gov (United States)

    Vishwanath, R; Moreno, J F

    2018-06-01

    It is approaching three decades since the first public evidence of sex-sorting of semen. The technology has progressed considerably since then with a number of institutions and researchers collaborating to eventually bring this to application. The technical challenges have been quite substantial and in the early years the application was limited to only heifer inseminations. Comparable fertility of sex-sorted semen with conventional semen has been an aspirational benchmark for the industry for many years. Significant investment in research in the primary biology of sex-sorted sperm and associated sorting equipment ensured steady progress over the years and current methods particularly the new SexedULTRA-4M™ seems to have now mostly bridged this fertility gap. The dairy and beef industry have adopted this technology quite rapidly. Other animal industries are progressively testing it for application in their specific niches and environments. The current state of the art in the fundamentals of sex-sorting, the biology of the process as well as new developments in machinery are described in this review.

  20. STATE OF THE ART TECHNIQUES USED FOR NOISE SOURCE IDENTIFICATION ON COMPLEX BODIES

    Directory of Open Access Journals (Sweden)

    Corneliu STOICA

    2010-03-01

    Full Text Available Over the last few decades, many approaches have been undertaken in order to asses detailed noise source identification on complex bodies, i.e. aircrafts, cars, machinery. Noise source identification implies to accurately obtain the position and frequency of the dominant noise sources. There are cases where traditional testing methods can not be applied at all or their use involves some limitations. Optical systems used for near field analysis require a line of sight that may not be available. The state-of-the-art technology for this purpose is the use of a large number of microphones whose signals are acquired simultaneously, i.e. microphone phased array. Due to the excessive cost of the instruments and the data acquisition system required, the implementation of this technology was restricted to governmental agencies (NASA, DLR and big companies such as Boeing and Airbus. During the past years, this technique was developed in wind tunnels and some universities to perform noise source identification on scale airframes, main landing gear models, and aerodynamic profiles (used on airplanes, helicopter rotors and wind mills.