UK Announces Intention to Join ESO

Science.gov (United States)

2000-11-01

Summary The Particle Physics and Astronomy Research Council (PPARC) , the UK's strategic science investment agency, today announced that the government of the United Kingdom is making funds available that provide a baseline for this country to join the European Southern Observatory (ESO) . The ESO Director General, Dr. Catherine Cesarsky , and the ESO Community warmly welcome this move towards fuller integration in European astronomy. "With the UK as a potential member country of ESO, our joint opportunities for front-line research and technology will grow significantly", she said. "This announcement is a clear sign of confidence in ESO's abilities, most recently demonstrated with the construction and operation of the unique Very Large Telescope (VLT) on Paranal. Together we will look forward with confidence towards new, exciting projects in ground-based astronomy." It was decided earlier this year to place the 4-m UK Visible and Infrared Survey Telescope (VISTA) at Paranal, cf. ESO Press Release 03/00. Following negotiations between ESO and PPARC, a detailed proposal for the associated UK/ESO Agreement with the various entry modalities will now be presented to the ESO Council for approval. Before this Agreement can enter into force, the ESO Convention and associated protocols must also be ratified by the UK Parliament. Research and key technologies According to the PPARC press release, increased funding for science, announced by the UK government today, will enable UK astronomers to prepare for the next generation of telescopes and expand their current telescope portfolio through membership of the European Southern Observatory (ESO). The uplift to its baseline budget will enable PPARC to enter into final negotiations for UK membership of the ESO. This will ensure that UK astronomers, together with their colleagues in the ESO member states, are actively involved in global scale preparations for the next generation of astronomy facilities. among these are ALMA

REOSC Delivers the Best Astronomical Mirror in the World to ESO

Science.gov (United States)

1999-12-01

employs about 15,500 people - more information is available at URL: www.sagem.com. Information about the ESO and the VLT project is available via the ESO website: www.eso.org. Some Key Dates The polishing at REOSC of the main mirrors for the four VLT Unit Telescopes has been a major industrial feat. Here are some of the main dates: July 1989 ESO and REOSC sign contract for the polishing of the four 8.2-m and various associated activities July 1989 - April 1992 Design activities, construction of REOSC production plant April 1992 Mirror Container and concrete dummy mirror blank completed - test transport May 1992 Inauguration of REOSC production plant July 1993 Delivery of first 8.2-m mirror blank to ESO at Schott Glaswerke AG (Mainz, Germany) October 1994 Delivery of second 8.2-m mirror blank to ESO at Schott Glaswerke AG September 1995 Delivery of third 8.2-m mirror blank to ESO at Schott Glaswerke AG May 1996 Acceptance by ESO of first polished mirror at REOSC September 1996 Delivery of fourth 8.2-m mirror blank to ESO at Schott Glaswerke AG October 1996 Acceptance by ESO of second polished mirror at REOSC June 1997 Acceptance by ESO of third polished mirror at REOSC October - December 1997 Transport and delivery of first mirror to Paranal by Gondrand (France) August - September 1998 Transport and delivery of second mirror to Paranal by Gondrand December 1998 - January 1999 Transport and delivery of third mirror to Paranal by Gondrand December 1999 Acceptance by ESO of fourth polished mirror at REOSC February 1999 - April 2000 Transport and delivery of fourth mirror to Paranal by Gondrand Note [1] A Press Release on the REOSC event and the delivery of the fourth VLT main mirror to ESO is also published by SAGEM (in French and English). How to obtain ESO Press Information ESO Press Information is made available on the World-Wide Web (URL: http://www.eso.org../ ). ESO PR Photo 44/99 may be reproduced, if credit is given to SAGEM and the European Southern Observatory.

ESO Receives Computerworld Honors Program 21st Century Achievement Award in Science Category

Science.gov (United States)

2005-06-01

In a ceremony held in Washington, D.C. (USA) on June 6, 2005, ESO, the European Organisation for Astronomical Research in the southern Hemisphere, received the coveted 21st Century Achievement Award from the Computerworld Honors Program for its visionary use of information technology in the Science category. Sybase, a main database server vendor and member of the Chairmen's Committee, nominated ESO's Data Flow System in recognition of its contributions to the global information technology revolution and its positive impact on society. The citations reads: "ESO has revolutionized the operations of ground-based astronomical observatories with a new end-to-end data flow system, designed to improve the transmission and management of astronomical observations and data over transcontinental distances." This year's awards, in 10 categories, were presented at a gala event at the National Building Museum, attended by over 250 guests, including leaders of the information technology industry, former award recipients, judges, scholars, and diplomats representing many of the 54 countries from which the 17-year-old program's laureates have come. "The Computerworld Honors Program 21st Century Achievement Awards are presented to companies from around the world whose visionary use of information technology promotes positive social, economic and educational change," said Bob Carrigan, president and CEO of Computerworld and chairman of the Chairmen's Committee of the Computerworld Honors Program. "The recipients of these awards are the true heroes of the information age and have been appropriately recognized by the leading IT industry chairmen as true revolutionaries in their fields." ESO PR Photo 18/05 ESO PR Photo 18/05 ESO Receives the Award in the Science Category [Preview - JPEG: 400 x 496 pix - 53k] [Normal - JPEG: 800 x 992 pix - 470k] [Full Res - JPEG: 1250 x 1550 pix - 1.1M] Caption: ESO PR Photo 18/05: Receiving the Computerworld 21st Century Achievement Award for Science

Current Discussions Between ESO and Chile

Science.gov (United States)

1995-04-01

[Joint Press Release by the Government of the Republic of Chile and the European Southern Observatory. The text is issued simultaneously in Santiago de Chile (in Spanish) and at the ESO Headquarters in Garching (in English).] Today, Tuesday, 18 April 1995, at the ESO Headquarters in Garching (Germany), Mr. Roberto Cifuentes, Plenipotentiary Ambassador representing the Government of the Republic of Chile, and the Director General of the European Southern Observatory, Professor Riccardo Giacconi, have signed a Supplementary, Interpretative and Amending Agreement to the Convention of 6 November 1963 which governs the relations between Chile and this International Organisation. This Agreement which in practice signifies a widening and strengthening of the cooperative relations between the Organisation and the Chilean scientific community will hereafter be submitted for ratification by the National Congress of the Republic of Chile (the Parliament) and by the ESO Council. According to the Agreement signed today, Chilean astronomers will have privileged access within up to 10 percent observing time on all present and future ESO telescopes in Chile. Moreover, ESO accepts to incorporate into its labour regulations for Chilean personnel concepts like freedom of association and collective bargaining. This signing of the Supplementary, Interpretative and Amending Agreement to the original Convention of 1963 follows after months of constructive dialogue between the parties. It constitutes an important step towards a solution of some of the pending points on the current agenda for discussions between the Government of Chile and ESO. Among the issues still pending, ESO has informed the Government of Chile that respect for its immunities by the Chilean State is of vital importance for the continuation of the construction of the world's largest telescope at Paranal, as well as the continued presence of the Organisation in Chile. The Chilean Government, on its side, and concerning

IUE observations of the hot components in two symbiotic stars. [R Agr and RW Hya, 1200 to 3200 A

Energy Technology Data Exchange (ETDEWEB)

Michalitsianos, A G [National Aeronautics and Space Administration, Greenbelt, MD (USA). Goddard Space Flight Center; Kafatos, M; Hobbs, R W; Maran, S P

1980-03-13

Ultraviolet measurements in the 1,200 - 3,200 A range are reported on two symbiotic stars, R Agr and RW Hya. The results indicate the presence of a hot component in each star, supporting the view that each is a binary system with a luminous red primary and a hot, sub-luminous companion. In the case of RW Hya the hot companion manifests itself by exciting a compact nebulosity while in the case of R Agr it is believed that the continuous spectrum of the hot star is directly detected, while the continuum of nebulosity excited by the hot star is detected at longer wavelengths.

Predicting Complex Organic Molecule Emission from TW Hya

Science.gov (United States)

Vissapragada, Shreyas; Walsh, Catherine

2017-01-01

The Atacama Large Millimeter/submillimeter Array (ALMA) has significantly increased our ability to observe the rich chemical inventory of star and planet formation. ALMA has recently been used to detect CH3OH (methanol) and CH3CN (methyl cyanide) in protoplanetary disks; these molecules may be vital indicators of the complex organic ice reservoir in the comet-forming zone. We have constructed a physiochemical model of TW Hya, a well-studied protoplanetary disk, to explore the different formation mechanisms of complex ices. By running our model through a radiative transfer code and convolving with beam sizes appropriate for ALMA, we have obtained synthetic observations of methanol and methyl cyanide. Here, we compare and comment on these synthetic observations, and provide astrochemical justification for their spatial distributions.

Blockbuster starring ESO Paranal opens tomorrow

Science.gov (United States)

2008-10-01

The 22nd James Bond adventure is due for release tomorrow, 31 October 2008, in the UK and a week later in the rest of the world. A key location in the movie is the Residencia, the hotel for astronomers and staff at ESO's Paranal Observatory. Blockbuster starring ESO Paranal opens tomorrow ESO PR Photo 38/08 The James Bond "Quantum of Solace" filmmakers Quantum of Solace is the latest film in one of most successful movie franchises -- that of renowned 007 Agent James Bond of the British Secret Service MI6. The agent "on Her Majesty's secret service" is once again played by Daniel Craig. Key scenes of the movie were filmed at Paranal, the home of ESO's Very Large Telescope, and the most advanced optical telescope in the world. Usually occupied by no more than 100 astronomers, engineers and technicians, Paranal welcomed the 300-strong film crew for several days of shooting at the end of March 2008. The crew travelled from their hotel base in Antofagasta for up to two hours each morning to reach the filming locations. "We are delighted to have a movie like this filmed at Paranal and it was extremely good to see how careful the crew were with the surroundings and how mindful they were of the fact that they were in an operating, working observatory", says Tim de Zeeuw, ESO Director General. "Paranal is a unique observatory in a unique setting and it is no real surprise that it plays a major part in a James Bond movie", he adds. The filmmakers were mostly interested in filming exterior scenes at the Paranal Residencia, the accommodation for staff operating the Very Large Telescope. In the movie, the Residencia is supposedly the "Perla de Las Dunas", a unique hotel in the desert. Cerro Paranal is a 2600 m high mountain in the Chilean Atacama Desert, perhaps the driest on Earth. The high altitude site and extreme dryness make excellent conditions for astronomical observations. To make it possible for people to live and work here, a hotel, or Residencia, was built at the

ESO's Two Observatories Merge

Science.gov (United States)

2005-02-01

On February 1, 2005, the European Southern Observatory (ESO) has merged its two observatories, La Silla and Paranal, into one. This move will help Europe's prime organisation for astronomy to better manage its many and diverse projects by deploying available resources more efficiently where and when they are needed. The merged observatory will be known as the La Silla Paranal Observatory. Catherine Cesarsky, ESO's Director General, comments the new development: "The merging, which was planned during the past year with the deep involvement of all the staff, has created unified maintenance and engineering (including software, mechanics, electronics and optics) departments across the two sites, further increasing the already very high efficiency of our telescopes. It is my great pleasure to commend the excellent work of Jorge Melnick, former director of the La Silla Observatory, and of Roberto Gilmozzi, the director of Paranal." ESO's headquarters are located in Garching, in the vicinity of Munich (Bavaria, Germany), and this intergovernmental organisation has established itself as a world-leader in astronomy. Created in 1962, ESO is now supported by eleven member states (Belgium, Denmark, Finland, France, Germany, Italy, The Netherlands, Portugal, Sweden, Switzerland, and the United Kingdom). It operates major telescopes on two remote sites, all located in Chile: La Silla, about 600 km north of Santiago and at an altitude of 2400m; Paranal, a 2600m high mountain in the Atacama Desert 120 km south of the coastal city of Antofagasta. Most recently, ESO has started the construction of an observatory at Chajnantor, a 5000m high site, also in the Atacama Desert. La Silla, north of the town of La Serena, has been the bastion of the organization's facilities since 1964. It is the site of two of the most productive 4-m class telescopes in the world, the New Technology Telescope (NTT) - the first major telescope equipped with active optics - and the 3.6-m, which hosts HARPS

ESO's Hidden Treasures Brought to Light

Science.gov (United States)

2011-01-01

ESO's Hidden Treasures 2010 astrophotography competition attracted nearly 100 entries, and ESO is delighted to announce the winners. Hidden Treasures gave amateur astronomers the opportunity to search ESO's vast archives of astronomical data for a well-hidden cosmic gem. Astronomy enthusiast Igor Chekalin from Russia won the first prize in this difficult but rewarding challenge - the trip of a lifetime to ESO's Very Large Telescope at Paranal, Chile. The pictures of the Universe that can be seen in ESO's releases are impressive. However, many hours of skilful work are required to assemble the raw greyscale data captured by the telescopes into these colourful images, correcting them for distortions and unwanted signatures of the instrument, and enhancing them so as to bring out the details contained in the astronomical data. ESO has a team of professional image processors, but for the ESO's Hidden Treasures 2010 competition, the experts decided to give astronomy and photography enthusiasts the opportunity to show the world what they could do with the mammoth amount of data contained in ESO's archives. The enthusiasts who responded to the call submitted nearly 100 entries in total - far exceeding initial expectations, given the difficult nature of the challenge. "We were completely taken aback both by the quantity and the quality of the images that were submitted. This was not a challenge for the faint-hearted, requiring both an advanced knowledge of data processing and an artistic eye. We are thrilled to have discovered so many talented people," said Lars Lindberg Christensen, Head of ESO's education and Public Outreach Department. Digging through many terabytes of professional astronomical data, the entrants had to identify a series of greyscale images of a celestial object that would reveal the hidden beauty of our Universe. The chance of a great reward for the lucky winner was enough to spur on the competitors; the first prize being a trip to ESO's Very Large

ESO Reflex: A Graphical Workflow Engine for Data Reduction

Science.gov (United States)

Hook, R.; Romaniello, M.; Péron, M.; Ballester, P.; Gabasch, A.; Izzo, C.; Ullgrén, M.; Maisala, S.; Oittinen, T.; Solin, O.; Savolainen, V.; Järveläinen, P.; Tyynelä, J.

2008-08-01

Sampo {http://www.eso.org/sampo} (Hook et al. 2005) is a project led by ESO and conducted by a software development team from Finland as an in-kind contribution to joining ESO. The goal is to assess the needs of the ESO community in the area of data reduction environments and to create pilot software products that illustrate critical steps along the road to a new system. Those prototypes will not only be used to validate concepts and understand requirements but will also be tools of immediate value for the community. Most of the raw data produced by ESO instruments can be reduced using CPL {http://www.eso.org/cpl} recipes: compiled C programs following an ESO standard and utilizing routines provided by the Common Pipeline Library. Currently reduction recipes are run in batch mode as part of the data flow system to generate the input to the ESO VLT/VLTI quality control process and are also made public for external users. Sampo has developed a prototype application called ESO Reflex {http://www.eso.org/sampo/reflex/} that integrates a graphical user interface and existing data reduction algorithms. ESO Reflex can invoke CPL-based recipes in a flexible way through a dedicated interface. ESO Reflex is based on the graphical workflow engine Taverna {http://taverna.sourceforge.net} that was originally developed by the UK eScience community, mostly for work in the life sciences. Workflows have been created so far for three VLT/VLTI instrument modes ( VIMOS/IFU {http://www.eso.org/instruments/vimos/}, FORS spectroscopy {http://www.eso.org/instruments/fors/} and AMBER {http://www.eso.org/instruments/amber/}), and the easy-to-use GUI allows the user to make changes to these or create workflows of their own. Python scripts and IDL procedures can be easily brought into workflows and a variety of visualisation and display options, including custom product inspection and validation steps, are available.

High-resolution Optical Spectroscopic Observations of Four Symbiotic Stars: AS 255, MWC 960, RW Hya, and StH α 32

Energy Technology Data Exchange (ETDEWEB)

Pereira, C. B.; Drake, N. A.; Roig, F. [Observatório Nacional/MCTIC, Rua Gen. José Cristino 77, Rio de Janeiro, 20921-400 (Brazil); Baella, N. O. [Unidad de Astronomía, Instituto Geofísico del Perú, Lima, Per (Peru); Miranda, L. F., E-mail: claudio@on.br, E-mail: drake@on.br, E-mail: froig@on.br, E-mail: nobar.baella@gmail.com, E-mail: lfm@iaa.es [Instituto de Astrofísica de Andalucía - CSIC, C/Glorieta de la Astronomía s/n, E-18008 Granada (Spain)

2017-05-20

We report on the analysis of high-resolution optical spectra of four symbiotic stars: AS 255, MWC 960, RW Hya, and StH α 32. We employ the local-thermodynamic-equilibrium model atmospheres of Kurucz and the spectral analysis code moog to analyze the spectra. The abundance of barium and carbon was derived using the spectral synthesis technique. The chemical composition of the atmospheres of AS 255 and MWC 960 show that they are metal-poor K giants with metallicities of −1.2 and −1.7 respectively. StH α 32 is a CH star and also a low-metallicity object (−1.4). AS 255 and MWC 960 are yellow symbiotic stars and, like other previously studied yellow symbiotics, are s -process enriched. StH α 32, like other CH stars, is also an s -process and carbon-enriched object. RW Hya has a metallicity of −0.64, a value in accordance with previous determinations, and is not s -process enriched. Based on its position in the 2MASS diagram, we suggest that RW Hya is at an intermediate position between yellow symbiotics and classical S-type symbiotics. We also discuss whether the dilution effect was the mechanism responsible for the absence of the s -process elements overabundance in RW Hya. The luminosity obtained for StH α 32 is below the luminosity of the asymptotic giant branch (AGB) stars that started helium burning (via thermal pulses) and became self-enriched in neutron-capture elements. Therefore, its abundance peculiarities are due to mass transfer from the previous thermally pulsing AGB star (now the white dwarf) that was overabundant in s -process elements. For the stars AS 255 and MWC 960, the determination of their luminosities was not possible due to uncertainties in their distance and interstellar absorption. AS 255 and MWC 960 have a low galactic latitude and could be bulge stars or members of the inner halo population. The heavy-element abundance distribution of AS 255 and MWC 960 is similar to that of the other yellow symbiotics previously analyzed. Their

High-resolution Optical Spectroscopic Observations of Four Symbiotic Stars: AS 255, MWC 960, RW Hya, and StH α 32

International Nuclear Information System (INIS)

Pereira, C. B.; Drake, N. A.; Roig, F.; Baella, N. O.; Miranda, L. F.

2017-01-01

We report on the analysis of high-resolution optical spectra of four symbiotic stars: AS 255, MWC 960, RW Hya, and StH α 32. We employ the local-thermodynamic-equilibrium model atmospheres of Kurucz and the spectral analysis code moog to analyze the spectra. The abundance of barium and carbon was derived using the spectral synthesis technique. The chemical composition of the atmospheres of AS 255 and MWC 960 show that they are metal-poor K giants with metallicities of −1.2 and −1.7 respectively. StH α 32 is a CH star and also a low-metallicity object (−1.4). AS 255 and MWC 960 are yellow symbiotic stars and, like other previously studied yellow symbiotics, are s -process enriched. StH α 32, like other CH stars, is also an s -process and carbon-enriched object. RW Hya has a metallicity of −0.64, a value in accordance with previous determinations, and is not s -process enriched. Based on its position in the 2MASS diagram, we suggest that RW Hya is at an intermediate position between yellow symbiotics and classical S-type symbiotics. We also discuss whether the dilution effect was the mechanism responsible for the absence of the s -process elements overabundance in RW Hya. The luminosity obtained for StH α 32 is below the luminosity of the asymptotic giant branch (AGB) stars that started helium burning (via thermal pulses) and became self-enriched in neutron-capture elements. Therefore, its abundance peculiarities are due to mass transfer from the previous thermally pulsing AGB star (now the white dwarf) that was overabundant in s -process elements. For the stars AS 255 and MWC 960, the determination of their luminosities was not possible due to uncertainties in their distance and interstellar absorption. AS 255 and MWC 960 have a low galactic latitude and could be bulge stars or members of the inner halo population. The heavy-element abundance distribution of AS 255 and MWC 960 is similar to that of the other yellow symbiotics previously analyzed. Their

Using ESO Reflex with Web Services

Science.gov (United States)

Järveläinen, P.; Savolainen, V.; Oittinen, T.; Maisala, S.; Ullgrén, M. Hook, R.

2008-08-01

ESO Reflex is a prototype graphical workflow system, based on Taverna, and primarily intended to be a flexible way of running ESO data reduction recipes along with other legacy applications and user-written tools. ESO Reflex can also readily use the Taverna Web Services features that are based on the Apache Axis SOAP implementation. Taverna is a general purpose Web Service client, and requires no programming to use such services. However, Taverna also has some restrictions: for example, no numerical types such integers. In addition the preferred binding style is document/literal wrapped, but most astronomical services publish the Axis default WSDL using RPC/encoded style. Despite these minor limitations we have created simple but very promising test VO workflow using the Sesame name resolver service at CDS Strasbourg, the Hubble SIAP server at the Multi-Mission Archive at Space Telescope (MAST) and the WESIX image cataloging and catalogue cross-referencing service at the University of Pittsburgh. ESO Reflex can also pass files and URIs via the PLASTIC protocol to visualisation tools and has its own viewer for VOTables. We picked these three Web Services to try to set up a realistic and useful ESO Reflex workflow. They also demonstrate ESO Reflex abilities to use many kind of Web Services because each of them requires a different interface. We describe each of these services in turn and comment on how it was used

ESO Reflex: a graphical workflow engine for data reduction

Science.gov (United States)

Hook, Richard; Ullgrén, Marko; Romaniello, Martino; Maisala, Sami; Oittinen, Tero; Solin, Otto; Savolainen, Ville; Järveläinen, Pekka; Tyynelä, Jani; Péron, Michèle; Ballester, Pascal; Gabasch, Armin; Izzo, Carlo

ESO Reflex is a prototype software tool that provides a novel approach to astronomical data reduction by integrating a modern graphical workflow system (Taverna) with existing legacy data reduction algorithms. Most of the raw data produced by instruments at the ESO Very Large Telescope (VLT) in Chile are reduced using recipes. These are compiled C applications following an ESO standard and utilising routines provided by the Common Pipeline Library (CPL). Currently these are run in batch mode as part of the data flow system to generate the input to the ESO/VLT quality control process and are also exported for use offline. ESO Reflex can invoke CPL-based recipes in a flexible way through a general purpose graphical interface. ESO Reflex is based on the Taverna system that was originally developed within the UK life-sciences community. Workflows have been created so far for three VLT/VLTI instruments, and the GUI allows the user to make changes to these or create workflows of their own. Python scripts or IDL procedures can be easily brought into workflows and a variety of visualisation and display options, including custom product inspection and validation steps, are available. Taverna is intended for use with web services and experiments using ESO Reflex to access Virtual Observatory web services have been successfully performed. ESO Reflex is the main product developed by Sampo, a project led by ESO and conducted by a software development team from Finland as an in-kind contribution to joining ESO. The goal was to look into the needs of the ESO community in the area of data reduction environments and to create pilot software products that illustrate critical steps along the road to a new system. Sampo concluded early in 2008. This contribution will describe ESO Reflex and show several examples of its use both locally and using Virtual Observatory remote web services. ESO Reflex is expected to be released to the community in early 2009.

Pricing Employee Stock Options (ESOs) with Random Lattice

Science.gov (United States)

Chendra, E.; Chin, L.; Sukmana, A.

2018-04-01

Employee Stock Options (ESOs) are stock options granted by companies to their employees. Unlike standard options that can be traded by typical institutional or individual investors, employees cannot sell or transfer their ESOs to other investors. The sale restrictions may induce the ESO’s holder to exercise them earlier. In much cited paper, Hull and White propose a binomial lattice in valuing ESOs which assumes that employees will exercise voluntarily their ESOs if the stock price reaches a horizontal psychological barrier. Due to nonlinearity errors, the numerical pricing results oscillate significantly so they may lead to large pricing errors. In this paper, we use the random lattice method to price the Hull-White ESOs model. This method can reduce the nonlinearity error by aligning a layer of nodes of the random lattice with a psychological barrier.

ESO takes the public on an astronomical journey "Around the World in 80 Telescopes"

Science.gov (United States)

2009-03-01

A live 24-hour free public video webcast, "Around the World in 80 Telescopes", will take place from 3 April 09:00 UT/GMT to 4 April 09:00 UT/GMT, chasing day and night around the globe to let viewers "visit" some of the most advanced astronomical telescopes on and off the planet. The webcast, organised by ESO for the International Year of Astronomy 2009 (IYA2009), is the first time that so many large observatories have been linked together for a public event. ESO PR Photo 13a/09 Map of Participating Observatories ESO PR Photo 13b/09 100 Hours of Astronomy logo Viewers will see new images of the cosmos, find out what observatories in their home countries or on the other side of the planet are discovering, send in questions and messages, and discover what astronomers are doing right now. Participating telescopes include those at observatories in Chile such as ESO's Very Large Telescope and La Silla, the Hawaii-based telescopes Gemini North and Keck, the Anglo-Australian Telescope, telescopes in the Canary Islands, the Southern African Large Telescope, space-based telescopes such as the NASA/ESA Hubble Space Telescope, ESA XMM-Newton and Integral, and many more. "Around the World in 80 Telescopes" will take viewers to every continent, including Antarctica! The webcast production will be hosted at ESO's headquarters near Munich, Germany, with live internet streaming by Ustream.tv. Anyone with a web browser supporting Adobe Flash will be able to follow the show, free of charge, from the website www.100hoursofastronomy.org and be a part of the project by sending messages and questions. The video player can be freely embedded on other websites. TV stations, web portals and science centres can also use the high quality feed. Representatives of the media who wish to report from the "front-line" and interview the team should get in touch. "Around the World in 80 Telescopes" is a major component of the 100 Hours of Astronomy (100HA), a Cornerstone project of the International

ESO celebrates 50 years of “Euro-astronomy”

CERN Multimedia

Anaïs Schaeffer

2012-01-01

Today the European Southern Observatory is celebrating its 50th anniversary. This article retraces the story of one of Europe's greatest laboratories, which came into being with CERN's support and assistance.   La Silla, June 1968. The three telescopes in the background are (from left to right): the Grand Prism Objectif (GPO, first light in 1968), the ESO 1 metre telescope (1966), and the ESO 1.5 metre telescope (1968). They have been decommissioned. The white dome closest to the viewer is the ESO 1 metre Schmidt telescope, which began work in 1971. Image: ESO/E. Maurice. In the spring of 1953, in Leiden in the Netherlands, a group of astronomers including Walter Baade, Jan Oort, Adriaan Blaauw, Otto Heckmann and Jan Bannier (who was then President of CERN's Provisional Council) for the first time discussed the possibility of founding a European space observatory. The objective was to build it in the southern hemisphere where there were very few observatories with pow...

ESO Science Outreach Network in Poland during 2011-2013

Science.gov (United States)

Czart, Krzysztof

2014-12-01

ESON Poland works since 2010. One of the main tasks of the ESO Science Outreach Network (ESON) is translation of various materials at ESO website, as well as contacts with journalists. We support also science festivals, conferences, contests, exhibitions, astronomy camps and workshops and other educational and outreach activities. During 2011-2013 we supported events like ESO Astronomy Camp 2013, ESO Industry Days in Warsaw, Warsaw Science Festival, Torun Festival of Science and Art, international astronomy olympiad held in Poland and many others. Among big tasks there was also translation of over 60 ESOcast movies.

ESO telbib: Linking In and Reaching Out

Science.gov (United States)

Grothkopf, U.; Meakins, S.

2015-04-01

Measuring an observatory's research output is an integral part of its science operations. Like many other observatories, ESO tracks scholarly papers that use observational data from ESO facilities and uses state-of-the-art tools to create, maintain, and further develop the Telescope Bibliography database (telbib). While telbib started out as a stand-alone tool mostly used to compile lists of papers, it has by now developed into a multi-faceted, interlinked system. The core of the telbib database is links between scientific papers and observational data generated by the La Silla Paranal Observatory residing in the ESO archive. This functionality has also been deployed for ALMA data. In addition, telbib reaches out to several other systems, including ESO press releases, the NASA ADS Abstract Service, databases at the CDS Strasbourg, and impact scores at Altmetric.com. We illustrate these features to show how the interconnected telbib system enhances the content of the database as well as the user experience.

Thirty-Seven Years of Service with ESO!

Science.gov (United States)

Breysacher, J.

2002-12-01

On December 1st, 2002, after thirty- seven years of service, first in Chile and then in Garching, Ms. Christa Euler will leave ESO to enjoy a welldeserved retirement. Among the current staff, she is probably the only person who started her career at ESO just four years after the Organization was founded.

The Strategic Partnership between ESO and Australia

Science.gov (United States)

Comendador Frutos, L.; de Zeeuw, T..; Geeraert, P.

2017-09-01

On 11 July 2017, ESO and the Australian government signed a ten-year Strategic Partnership arrangement giving Australian astronomers access to the La Silla Paranal facilities. The path towards this arrangement is briefly outlined and the details of the Partnership and its implications for both the Australian and ESO astronomical communities are summarised.

The ESO Survey of Non-Publishing Programmes

Science.gov (United States)

Patat, F.; Boffin, H. M. J.; Bordelon, D.; Grothkopf, U.; Meakins, S.; Mieske, S.; Rejkuba, M.

2017-12-01

One of the classic ways to measure the success of a scientific facility is the publication return, which is defined as the refereed papers produced per unit of allocated resources (for example, telescope time or proposals). The recent studies by Sterzik et al. (2015, 2016) have shown that 30–50 % of the programmes allocated time at ESO do not produce a refereed publication. While this may be inherent to the scientific process, this finding prompted further investigation. For this purpose, ESO conducted a Survey of Non-Publishing Programmes (SNPP) within the activities of the Time Allocation Working Group, similar to the monitoring campaign that was recently implemented at ALMA (Stoehr et al., 2016). The SNPP targeted 1278 programmes scheduled between ESO Periods 78 and 90 (October 2006 to March 2013) that had not published a refereed paper as of April 2016. The poll was launched on 6 May 2016, remained open for four weeks, and returned 965 valid responses. This article summarises and discusses the results of this survey, the first of its kind at ESO.

The 2007 ESO Instrument Calibration Workshop

CERN Document Server

Kaufer, Andreas; ESO Workshop

2008-01-01

The 2007 ESO Instrument Calibration workshop brought together more than 120 participants with the objective to a) foster the sharing of information, experience and techniques between observers, instrument developers and instrument operation teams, b) review the actual precision and limitations of the applied instrument calibration plans, and c) collect the current and future requirements by the ESO users. These present proceedings include the majority of the workshop’s contributions and document the status quo of instrument calibration at ESO in large detail. Topics covered are: Optical Spectro-Imagers, Optical Multi-Object Spectrographs, NIR and MIR Spectro-Imagers, High-Resolution Spectrographs, Integral Field Spectrographs, Adaptive Optics Instruments, Polarimetric Instruments, Wide Field Imagers, Interferometric Instruments as well as other crucial aspects such as data flow, quality control, data reduction software and atmospheric effects. It was stated in the workshop that "calibration is a life-long l...

Vaccination with NY-ESO-1 overlapping peptides mixed with Picibanil OK-432 and montanide ISA-51 in patients with cancers expressing the NY-ESO-1 antigen.

Science.gov (United States)

Wada, Hisashi; Isobe, Midori; Kakimi, Kazuhiro; Mizote, Yu; Eikawa, Shingo; Sato, Eiichi; Takigawa, Nagio; Kiura, Katsuyuki; Tsuji, Kazuhide; Iwatsuki, Keiji; Yamasaki, Makoto; Miyata, Hiroshi; Matsushita, Hirokazu; Udono, Heiichiro; Seto, Yasuyuki; Yamada, Kazuhiro; Nishikawa, Hiroyoshi; Pan, Linda; Venhaus, Ralph; Oka, Mikio; Doki, Yuichiro; Nakayama, Eiichi

2014-01-01

We conducted a clinical trial of an NY-ESO-1 cancer vaccine using 4 synthetic overlapping long peptides (OLP; peptides #1, 79-108; #2, 100-129; #3, 121-150; and #4, 142-173) that include a highly immunogenic region of the NY-ESO-1 molecule. Nine patients were immunized with 0.25 mg each of three 30-mer and a 32-mer long NY-ESO-1 OLP mixed with 0.2 KE Picibanil OK-432 and 1.25 mL Montanide ISA-51. The primary endpoints of this study were safety and NY-ESO-1 immune responses. Five to 18 injections of the NY-ESO-1 OLP vaccine were well tolerated. Vaccine-related adverse events observed were fever and injection site reaction (grade 1 and 2). Two patients showed stable disease after vaccination. An NY-ESO-1-specific humoral immune response was observed in all patients and an antibody against peptide #3 (121-150) was detected firstly and strongly after vaccination. NY-ESO-1 CD4 and CD8 T-cell responses were elicited in these patients and their epitopes were identified. Using a multifunctional cytokine assay, the number of single or double cytokine-producing cells was increased in NY-ESO-1-specific CD4 and CD8 T cells after vaccination. Multiple cytokine-producing cells were observed in PD-1 (-) and PD-1 (+) CD4 T cells. In conclusion, our study indicated that the NY-ESO-1 OLP vaccine mixed with Picibanil OK-432 and Montanide ISA-51 was well tolerated and elicited NY-ESO-1-specific humoral and CD4 and CD8 T-cell responses in immunized patients.

Overview of ESO Large Single Dish Study

Science.gov (United States)

Testi, Leonardo

2018-01-01

In this talk I will briefly summarize the motivation, methodology and outcome of the ESO Submm Single Dish Strategy WG. The WG was established by the ESO Director for Science and completed its work at the end of 2015. I will summarize the status of the report recommendations, which, among other things, led to the organization of the AtLAST workshop.

The ESO S-3000 measuring machine

CERN Document Server

West, R M

1975-01-01

The ESO S-3000 measuring machine which was installed in 1974 in the Sky Atlas Laboratory is capable of measuring photographic plates up to 14*14 inch/sup 2/ with a formal accuracy of +or-1 mu m and +or-.02 D in position and density. It is controlled by a 8 k Alpha 16 minicomputer. Software has been written for the ESO-TP HP 2100 computer system, that permits recognition and accurate measurement of stellar and extended images and filtering of plate faults. (1 refs).

NY-ESO-1 Based Immunotherapy of Cancer: Current Perspectives

Directory of Open Access Journals (Sweden)

Remy Thomas

2018-05-01

Full Text Available NY-ESO-1 or New York esophageal squamous cell carcinoma 1 is a well-known cancer-testis antigen (CTAs with re-expression in numerous cancer types. Its ability to elicit spontaneous humoral and cellular immune responses, together with its restricted expression pattern, have rendered it a good candidate target for cancer immunotherapy. In this review, we provide background information on NY-ESO-1 expression and function in normal and cancerous tissues. Furthermore, NY-ESO-1-specific immune responses have been observed in various cancer types; however, their utility as biomarkers are not well determined. Finally, we describe the immune-based therapeutic options targeting NY-ESO-1 that are currently in clinical trial. We will highlight the recent advancements made in NY-ESO-1 cancer vaccines, adoptive T cell therapy, and combinatorial treatment with checkpoint inhibitors and will discuss the current trends for future NY-ESO-1 based immunotherapy. Cancer treatment has been revolutionized over the last few decades with immunotherapy emerging at the forefront. Immune-based interventions have shown promising results, providing a new treatment avenue for durable clinical responses in various cancer types. The majority of successful immunotherapy studies have been reported in liquid cancers, whereas these approaches have met many challenges in solid cancers. Effective immunotherapy in solid cancers is hampered by the complex, dynamic tumor microenvironment that modulates the extent and phenotype of the antitumor immune response. Furthermore, many solid tumor-associated antigens are not private but can be found in normal somatic tissues, resulting in minor to detrimental off-target toxicities. Therefore, there is an ongoing effort to identify tumor-specific antigens to target using various immune-based modalities. CTAs are considered good candidate targets for immunotherapy as they are characterized by a restricted expression in normal somatic tissues

ESO science data product standard for 1D spectral products

Science.gov (United States)

Micol, Alberto; Arnaboldi, Magda; Delmotte, Nausicaa A. R.; Mascetti, Laura; Retzlaff, Joerg

2016-07-01

The ESO Phase 3 process allows the upload, validation, storage, and publication of reduced data through the ESO Science Archive Facility. Since its introduction, 2 million data products have been archived and published; 80% of them are one-dimensional extracted and calibrated spectra. Central to Phase3 is the ESO science data product standard that defines metadata and data format of any product. This contribution describes the ESO data standard for 1d-spectra, its adoption by the reduction pipelines of selected instrument modes for in-house generation of reduced spectra, the enhanced archive legacy value. Archive usage statistics are provided.

Impact of anthropogenic ocean acidification on thermal tolerance of the spider crab Hyas araneus

Directory of Open Access Journals (Sweden)

H. O. Pörtner

2009-10-01

Full Text Available Future scenarios for the oceans project combined developments of CO2 accumulation and global warming and their impact on marine ecosystems. The synergistic impact of both factors was addressed by studying the effect of elevated CO2 concentrations on thermal tolerance of the cold-eurythermal spider crab Hyas araneus from the population around Helgoland. Here ambient temperatures characterize the southernmost distribution limit of this species. Animals were exposed to present day normocapnia (380 ppm CO2, CO2 levels expected towards 2100 (710 ppm and beyond (3000 ppm. Heart rate and haemolymph PO2 (PeO2 were measured during progressive short term cooling from 10 to 0°C and during warming from 10 to 25°C. An increase of PeO2 occurred during cooling, the highest values being reached at 0°C under all three CO2 levels. Heart rate increased during warming until a critical temperature (Tc was reached. The putative Tc under normocapnia was presumably >25°C, from where it fell to 23.5°C under 710 ppm and then 21.1°C under 3000 ppm. At the same time, thermal sensitivity, as seen in the Q10 values of heart rate, rose with increasing CO2 concentration in the warmth. Our results suggest a narrowing of the thermal window of Hyas araneus under moderate increases in CO2 levels by exacerbation of the heat or cold induced oxygen and capacity limitation of thermal tolerance.

The Potential of ESO for Asteroseismology

Science.gov (United States)

Aerts, Conny

2017-08-01

The research field of asteroseismology is currently undergoing its first revolution. We start with a brief history of how this field of stellar physics evolved from dream to reality, including ESO's role in it. Subsequently, we highlight how asteroseismology can serve various topics in astrophysics and focus on the current status. We discuss recent findings on the rotation and chemical mixing inside stars. Finally, we look at the perspectives of the second and third revolution in this area and highlight how ESO can play an optimal role in it.

Shaping ESO2020+ Together: Feedback from the Community Poll

Science.gov (United States)

Primas, F.; Ivison, R.; Berger, J.-P.; Caselli, P.; De Gregorio-Monsalvo, I.; Alonso Herrero, A.; Knudsen, K. K.; Leibundgut, B.; Moitinho, A.; Saviane, I.; Spyromilio, J.; Testi, L.; Vennes, S.

2015-09-01

A thorough evaluation and prioritisation of the ESO science programme into the 2020+ timeframe took place under the auspices of a working group, comprising astronomers drawn from ESO’s advisory structure and from within ESO. This group reported to ESO’s Scientific Technical Committee, and to ESO Council, concluding the exercise with the publication of a report, “Science Priorities at ESO”. A community poll and a dedicated workshop, held in January 2015, formed part of the information gathering process. The community poll was designed to probe the demographics of the user community, its scientific interests, use of observing facilities and plans for use of future telescopes and instruments, its views on types of observing programmes and on the provision of data processing and archiving. A total of 1775 full responses to the poll were received and an analysis of the results is presented here. Foremost is the importance of regular observing programmes on all ESO observing facilities, in addition to Large Programmes and Public Surveys. There was also a strong community requirement for ESO to process and archive data obtained at ESO facilities. Other aspects, especially those related to future facilities, are more challenging to interpret because of biases related to the distribution of science expertise and favoured wavelength regime amongst the targeted audience. The results of the poll formed a fundamental component of the report and pro-vide useful data to guide the evolution of ESO’s science programme.

Mechanical thrombectomy in acute ischemic stroke: Consensus statement by ESO-Karolinska Stroke Update 2014/2015, supported by ESO, ESMINT, ESNR and EAN.

Science.gov (United States)

Wahlgren, Nils; Moreira, Tiago; Michel, Patrik; Steiner, Thorsten; Jansen, Olav; Cognard, Christophe; Mattle, Heinrich P; van Zwam, Wim; Holmin, Staffan; Tatlisumak, Turgut; Petersson, Jesper; Caso, Valeria; Hacke, Werner; Mazighi, Mikael; Arnold, Marcel; Fischer, Urs; Szikora, Istvan; Pierot, Laurent; Fiehler, Jens; Gralla, Jan; Fazekas, Franz; Lees, Kennedy R

2016-01-01

The original version of this consensus statement on mechanical thrombectomy was approved at the European Stroke Organisation (ESO)-Karolinska Stroke Update conference in Stockholm, 16-18 November 2014. The statement has later, during 2015, been updated with new clinical trials data in accordance with a decision made at the conference. Revisions have been made at a face-to-face meeting during the ESO Winter School in Berne in February, through email exchanges and the final version has then been approved by each society. The recommendations are identical to the original version with evidence level upgraded by 20 February 2015 and confirmed by 15 May 2015. The purpose of the ESO-Karolinska Stroke Update meetings is to provide updates on recent stroke therapy research and to discuss how the results may be implemented into clinical routine. Selected topics are discussed at consensus sessions, for which a consensus statement is prepared and discussed by the participants at the meeting. The statements are advisory to the ESO guidelines committee. This consensus statement includes recommendations on mechanical thrombectomy after acute stroke. The statement is supported by ESO, European Society of Minimally Invasive Neurological Therapy (ESMINT), European Society of Neuroradiology (ESNR), and European Academy of Neurology (EAN). © 2016 World Stroke Organization.

Aprendizaje significativo de la clasificación de los seres vivos en primero de la ESO

OpenAIRE

Grajeras Cid, Miriam

2013-01-01

En este trabajo fin de máster voy a abordar el tema de los seres vivos en 1º de la ESO ya que este fue el tema que impartí en el IESO Pedro de Atarrabia durante mi estancia en prácticas. En otras asignaturas del máster hemos visto como el alumnado de secundaria tiene muchos errores conceptuales, los cuales hay que corregir para que el alumnado tenga un aprendizaje significativo. Ante la dificultad de corregir estos errores, voy a desarrollar una propuesta didáctica en la que el alumnado apren...

ESO: The CERN Years

CERN Multimedia

Schaeffer, A

2012-01-01

In 1970, CERN and ESO signed a collaboration agreement for the construction of the Observatory’s first telescope. That same year, ESO’s Telescope Division and Sky Atlas laboratory settled on the CERN site in Meyrin. Let’s turn back to the beginnings of this lasting and fruitful alliance.

KINEMATICS OF THE CO GAS IN THE INNER REGIONS OF THE TW Hya DISK

Energy Technology Data Exchange (ETDEWEB)

Rosenfeld, Katherine A.; Qi Chunhua; Andrews, Sean M.; Wilner, David J. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Corder, Stuartt A. [National Radio Astronomy Observatory, 520 Edgemont Road, Charlottesville, VA 22903 (United States); Dullemond, C. P. [Institut fuer Theoretische Astrophysik, Universitaet Heidelberg, Albert-Ueberle-Str. 2, D-69120 Heidelberg (Germany); Lin Shinyi [Department of Physics, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 (United States); Hughes, A. M. [Department of Astronomy, University of California at Berkeley, 601 Campbell Hall, Berkeley, CA 94720 (United States); D' Alessio, Paola [Centro de Radioastronomia y Astrofisica, Universidad Nacional Autonoma de Mexico, Apartado Postal 72-3 (Xangari), 58089 Morelia, Michoacan (Mexico); Ho, P. T. P. [Academia Sinica Institute of Astronomy and Astrophysics, P.O. Box 23-141, Taipei 106, Taiwan (China)

2012-10-01

We present a detailed analysis of the spatially and spectrally resolved {sup 12}CO J = 2-1 and J = 3-2 emission lines from the TW Hya circumstellar disk, based on science verification data from the Atacama Large Millimeter/submillimeter Array (ALMA). These lines exhibit substantial emission in their high-velocity wings (with projected velocities out to 2.1 km s{sup -1}, corresponding to intrinsic orbital velocities >20 km s{sup -1}) that trace molecular gas as close as 2 AU from the central star. However, we are not able to reproduce the intensity of these wings and the general spatio-kinematic pattern of the lines with simple models for the disk structure and kinematics. Using three-dimensional non-local thermodynamic equilibrium molecular excitation and radiative transfer calculations, we construct some alternative models that successfully account for these features by modifying either (1) the temperature structure of the inner disk (inside the dust-depleted disk cavity; r < 4 AU), (2) the intrinsic (Keplerian) disk velocity field, or (3) the distribution of disk inclination angles (a warp). The latter approach is particularly compelling because a representative warped disk model qualitatively reproduces the observed azimuthal modulation of optical light scattered off the disk surface. In any model scenario, the ALMA data clearly require a substantial molecular gas reservoir located inside the region where dust optical depths are known to be substantially diminished in the TW Hya disk, in agreement with previous studies based on infrared spectroscopy. The results from these updated model prescriptions are discussed in terms of their potential physical origins, which might include dynamical perturbations from a low-mass companion with an orbital separation of a few AU.

A phase I study of vaccination with NY-ESO-1f peptide mixed with Picibanil OK-432 and Montanide ISA-51 in patients with cancers expressing the NY-ESO-1 antigen.

Science.gov (United States)

Kakimi, Kazuhiro; Isobe, Midori; Uenaka, Akiko; Wada, Hisashi; Sato, Eiichi; Doki, Yuichiro; Nakajima, Jun; Seto, Yasuyuki; Yamatsuji, Tomoki; Naomoto, Yoshio; Shiraishi, Kenshiro; Takigawa, Nagio; Kiura, Katsuyuki; Tsuji, Kazuhide; Iwatsuki, Keiji; Oka, Mikio; Pan, Linda; Hoffman, Eric W; Old, Lloyd J; Nakayama, Eiichi

2011-12-15

We conducted a phase I clinical trial of a cancer vaccine using a 20-mer NY-ESO-1f peptide (NY-ESO-1 91-110) that includes multiple epitopes recognized by antibodies, and CD4 and CD8 T cells. Ten patients were immunized with 600 μg of NY-ESO-1f peptide mixed with 0.2 KE Picibanil OK-432 and 1.25 ml Montanide ISA-51. Primary end points of the study were safety and immune response. Subcutaneous injection of the NY-ESO-1f peptide vaccine was well tolerated. Vaccine-related adverse events observed were fever (Grade 1), injection-site reaction (Grade 1 or 2) and induration (Grade 2). Vaccination with the NY-ESO-1f peptide resulted in an increase or induction of NY-ESO-1 antibody responses in nine of ten patients. The sera reacted with recombinant NY-ESO-1 whole protein as well as the NY-ESO-1f peptide. An increase in CD4 and CD8 T cell responses was observed in nine of ten patients. Vaccine-induced CD4 and CD8 T cells responded to NY-ESO-1 91-108 in all patients with various HLA types with a less frequent response to neighboring peptides. The findings indicate that the 20-mer NY-ESO-1f peptide includes multiple epitopes recognized by CD4 and CD8 T cells with distinct specificity. Of ten patients, two with lung cancer and one with esophageal cancer showed stable disease. Our study shows that the NY-ESO-1f peptide vaccine was well tolerated and elicited humoral, CD4 and CD8 T cell responses in immunized patients. Copyright © 2011 UICC.

ESTUDIO SOBRE PRÁCTICAS DOCENTES EN EVALUACIÓN DE LA LENGUA INGLESA EN LA ESO

Directory of Open Access Journals (Sweden)

Fernando D. Rubio

2012-01-01

Full Text Available Se critica la enseñanza del inglés en España y los resultados de aprendizaje. En este artículo se advierte que en parte se debe a la ausencia de evaluación oral en la ESO, y para ello se han analizado las prácticas docentes de evaluación. Se recogieron instrumentos de evaluación utilizados, en nuestro caso exámenes, y se analizaron sus contenidos. Los resultados obtenidos indican que las destrezas orales apenas se evalúan, que los elementos comunicativos son casi inexistentes y que no se siguen algunos criterios de evaluación marcados por la ley.

La física de la próxima década

OpenAIRE

Paz, Juan Pablo

2015-01-01

Esta frase, atribuida a Niels Bohr, es apropiada para encabezar un artículo que intenta predecir las cuestiones centrales de la física de la próxima década. Hoy, muchos problemas relevantes, tal vez los más relevantes, requieren de un enfoque interdisciplinario. No son problemas exclusivos de la física y por eso no los mencionaré aquí. Presentaré, en cambio, una selección subjetiva y discrecional de los temas centrales de la física que, a mi juicio, serán los protagonistas de la década. Mi pr...

The VANDELS ESO spectroscopic survey

Science.gov (United States)

McLure, R. J.; Pentericci, L.; Cimatti, A.; Dunlop, J. S.; Elbaz, D.; Fontana, A.; Nandra, K.; Amorin, R.; Bolzonella, M.; Bongiorno, A.; Carnall, A. C.; Castellano, M.; Cirasuolo, M.; Cucciati, O.; Cullen, F.; De Barros, S.; Finkelstein, S. L.; Fontanot, F.; Franzetti, P.; Fumana, M.; Gargiulo, A.; Garilli, B.; Guaita, L.; Hartley, W. G.; Iovino, A.; Jarvis, M. J.; Juneau, S.; Karman, W.; Maccagni, D.; Marchi, F.; Mármol-Queraltó, E.; Pompei, E.; Pozzetti, L.; Scodeggio, M.; Sommariva, V.; Talia, M.; Almaini, O.; Balestra, I.; Bardelli, S.; Bell, E. F.; Bourne, N.; Bowler, R. A. A.; Brusa, M.; Buitrago, F.; Caputi, K. I.; Cassata, P.; Charlot, S.; Citro, A.; Cresci, G.; Cristiani, S.; Curtis-Lake, E.; Dickinson, M.; Fazio, G. G.; Ferguson, H. C.; Fiore, F.; Franco, M.; Fynbo, J. P. U.; Galametz, A.; Georgakakis, A.; Giavalisco, M.; Grazian, A.; Hathi, N. P.; Jung, I.; Kim, S.; Koekemoer, A. M.; Khusanova, Y.; Le Fèvre, O.; Lotz, J. M.; Mannucci, F.; Maltby, D. T.; Matsuoka, K.; McLeod, D. J.; Mendez-Hernandez, H.; Mendez-Abreu, J.; Mignoli, M.; Moresco, M.; Mortlock, A.; Nonino, M.; Pannella, M.; Papovich, C.; Popesso, P.; Rosario, D. P.; Salvato, M.; Santini, P.; Schaerer, D.; Schreiber, C.; Stark, D. P.; Tasca, L. A. M.; Thomas, R.; Treu, T.; Vanzella, E.; Wild, V.; Williams, C. C.; Zamorani, G.; Zucca, E.

2018-05-01

VANDELS is a uniquely-deep spectroscopic survey of high-redshift galaxies with the VIMOS spectrograph on ESO's Very Large Telescope (VLT). The survey has obtained ultra-deep optical (0.48 studies. Using integration times calculated to produce an approximately constant signal-to-noise ratio (20 motivation, survey design and target selection.

Photometry of the long period dwarf nova GY Hya

Science.gov (United States)

Bruch, Albert; Monard, Berto

2017-08-01

Although comparatively bright, the cataclysmic variable GY Hya has not attracted much attention in the past. As part of a project to better characterize such systems photometrically, we observed light curves in white light, each spanning several hours, at Bronberg Observatory, South Africa, in 2004 and 2005, and at the Observatório do Pico dos Dias, Brazil, in 2014 and 2016. These data permit to study orbital modulations and their variations from season to season. The orbital period, already known from spectroscopic observations of Peters and Thorstensen (2005), is confirmed through strong ellipsoidal variations of the mass donor star in the system and the presence of eclipses of both components. A refined period of 0.34723972 (6) days and revised ephemeries are derived. Seasonal changes in the average orbital light curve can qualitatively be explained by variations of the contribution of a hot spot to the system light together with changes of the disk radius. The amplitude of the ellipsoidal variations and the eclipse contact phases permit to put some constraints on the mass ratio, orbital inclination and the relative brightness of the primary and secondary components. There are some indications that the disk radius during quiescence, expressed in units of the component separation, is smaller than in other dwarf novae.

ESO Catalogue Facility Design and Performance

Science.gov (United States)

Moins, C.; Retzlaff, J.; Arnaboldi, M.; Zampieri, S.; Delmotte, N.; Forchí, V.; Klein Gebbinck, M.; Lockhart, J.; Micol, A.; Vera Sequeiros, I.; Bierwirth, T.; Peron, M.; Romaniello, M.; Suchar, D.

2013-10-01

The ESO Phase 3 Catalogue Facility provides investigators with the possibility to ingest catalogues resulting from ESO public surveys and large programs and to query and download their content according to positional and non-positional criteria. It relies on a chain of tools that covers the complete workflow from submission to validation and ingestion into the ESO archive and catalogue repository and a web application to browse and query catalogues. This repository consists of two components. One is a Sybase ASE relational database where catalogue meta-data are stored. The second one is a Sybase IQ data warehouse where the content of each catalogue is ingested in a specific table that returns all records matching a user's query. Spatial indexing has been implemented in Sybase IQ to speed up positional queries and relies on the Spherical Geometry Toolkit from the Johns Hopkins University which implements the Hierarchical Triangular Mesh (HTM) algorithm. It is based on a recursive decomposition of the celestial sphere in spherical triangles and the assignment of an index to each of them. It has been complemented with the use of optimized indexes on the non-positional columns that are likely to be frequently used as query constraints. First tests performed on catalogues such as 2MASS have confirmed that this approach provides a very good level of performance and a smooth user experience that are likely to facilitate the scientific exploitation of catalogues.

News from the ESO Science Archive Facility

Science.gov (United States)

Dobrzycki, A.; Arnaboldi, M.; Bierwirth, T.; Boelter, M.; Da Rocha, C.; Delmotte, N.; Forchì, V.; Fourniol, N.; klein Gebbinck, M.; Lange, U.; Mascetti, L.; Micol, A.; Moins, C.; Munte, C.; Pluciennik, C.; Retzlaff, J.; Romaniello, M.; Rosse, N.; Sequeiros, I. V.; Vuong, M.-H.; Zampieri, S.

2015-09-01

ESO Science Archive Facility (SAF) - one of the world's biggest astronomical archives - combines two roles: operational (ingest, tallying, safekeeping and distribution to observers of raw data taken with ESO telescopes and processed data generated both internally and externally) and scientific (publication and delivery of all flavours of data to external users). This paper presents the “State of the SAF.” SAF, as a living entity, is constantly implementing new services and upgrading the existing ones. We present recent and future developments related to the Archive's Request Handler and metadata handling as well as performance and usage statistics and trends. We also discuss the current and future datasets on offer at SAF.

ESO Telescope Designer Raymond Wilson Wins Prestigious Kavli Award for Astrophysics

Science.gov (United States)

2010-06-01

Raymond Wilson, whose pioneering optics research at ESO made today's giant telescopes possible thanks to "active optics" technology, has been awarded the 2010 Kavli Prize in astrophysics. The founder and original leader of the Optics and Telescopes Group at ESO, Wilson shares the million-dollar prize with two American scientists, Jerry Nelson and Roger Angel. The biennial prize, presented by the Norwegian Academy of Science and Letters, the Kavli Foundation, and the Norwegian Ministry of Education and Research, was instituted in 2008 and is given to researchers who significantly advance knowledge in the fields of nanoscience, neuroscience, and astrophysics, acting as a complement to the Nobel Prize. The award is named for and funded by Fred Kavli, the Norwegian entrepreneur and phi­lanthropist who later founded the Kavlico Corpora­tion in the US - today one of the world's largest suppliers of sensors for aeronautic, automotive and industrial applications. Wilson, who joined ESO in 1972, strived to achieve optical perfection, developing the concept of active optics as a way to enhance the size of telescopic primary mirrors. It is the size of these mirrors that determines the ability of a telescope to gather light and study faint and distant objects. Before active optics, mirrors over six metres in diameter were impossible, being too heavy, costly, and likely to bend from gravity and temperature changes. The use of active optics, which preserves optimal image quality by continually adjusting the mirror's shape during observations, made lighter, thinner so-called "meniscus mirrors" possible. Wilson first led the implementation of active optics in the revolutionary New Technology Telescope at ESO's La Silla Observatory, and continued to develop and improve the technology until his retirement in 1993. Since then, active optics have become a standard part of modern astronomy, applied in every big telescope including ESO's Very Large Telescope (VLT), a telescope array

Participant Perspectives on the ESO Astronomy Camp Programme

Science.gov (United States)

Olivotto, C.; Cenadelli, D.; Gamal, M.; Grossmann, D.; Teller, L. A. I.; Marta, A. S.; Matoni, C. L.; Taillard, A.

2015-09-01

This article describes the experience of attending the European Southern Observatory (ESO) Astronomy Camp from the perspective of its participants - students aged between 16 and 18 years old from around the world. The students shared a week together during the winter of 2014 in the Alpine village of Saint-Barthelemy, Italy. The camp was organised by ESO in collaboration with Sterrenlab and the Astronomical Observatory of the Autonomous Region of the Aosta Valley and offered a rich programme of astronomy and leisure activities. This article focuses on the concept of astronomy camps, and their role as a unique tool to complement formal classroom education, rather than on the astronomy activities and the scientific programme. Thus, it is not an academic review of the implemented methodologies, but rather a reflection on the overall experience. The article was brought together from collaborative accounts by some of the participants who were asked to reflect on the experience. The participants who contributed to this article represent the diversity of the ESO Astronomy Camp's alumni community.

ESO Council Visits First VLT Unit Telescope Structure in Milan

Science.gov (United States)

1995-12-01

As the ESO Very Large Telescope (VLT) rapidly takes on shape, Europe has just come one step closer to the realisation of its 556 million DEM astronomical showcase project. Last week, the ESO Council held its semi-annual meeting in Milan (Italy) [1]. During a break in the long agenda list, Council members had the opportunity to visit the Ansaldo factory in the outskirts of this city and to see for the first time the assembled mechanical structure of one of the four 8.2-metre VLT Unit telescopes. This Press Release is accompanied by a photo that shows the ESO Council delegates in front of the giant telescope. After a long climb up the steep staircase to the large Nasmyth platform at the side of the telescope where the astronomical instruments will later be placed, Dr. Peter Creola (Switzerland) , President of the ESO Council and a mechanics expert, grabbed the handrail and surveyed the structure with a professional eye: `I knew it was going to be big, but not that enormous!', he said. Other delegates experienced similar feelings, especially when they watched the 430 tonnes of steel in the 24-metre tall and squat structure turn smoothly and silently around the vertical axis. The Chairman of the ESO Scientific Technical Committee (STC), Dr. Johannes Andersen (Denmark) , summarized his first, close encounter with the VLT by `This is great fun!' and several of his colleague astronomers were soon seen in various corners of the vast structure, engaged in elated discussions about the first scientific investigations to be done with the VLT in two years' time. The VLT Main Structures The visit by Council took place at the invitation of Ansaldo Energia S.p.A. (Genova), EIE-European Industrial Engineering S.r.I. (Venice) and SOIMI-Societa Impianti Industriale S.p.A. (Milan), the three Italian enterprises responsible for the construction of the main structures of the VLT 8.2-metre Unit telescopes. Short speeches were given on this occasion by Drs. Ferruccio Bressani (Ansaldo

Increased NY-ESO-1 Expression and Reduced Infiltrating CD3+ T Cells in Cutaneous Melanoma

Directory of Open Access Journals (Sweden)

Mara Giavina-Bianchi

2015-01-01

Full Text Available NY-ESO-1 is a cancer-testis antigen aberrantly expressed in melanomas, which may serve as a robust and specific target in immunotherapy. NY-ESO-1 antigen expression, tumor features, and the immune profile of tumor infiltrating lymphocytes were assessed in primary cutaneous melanoma. NY-ESO-1 protein was detected in 20% of invasive melanomas (16/79, rarely in in situ melanoma (1/10 and not in benign nevi (0/20. Marked intratumoral heterogeneity of NY-ESO-1 protein expression was observed. NY-ESO-1 expression was associated with increased primary tumor thickness (P=0.007 and inversely correlated with superficial spreading melanoma (P<0.02. NY-ESO-1 expression was also associated with reduced numbers and density of CD3+ tumor infiltrating lymphocytes (P=0.017. When NY-ESO-1 protein was expressed, CD3+ T cells were less diffusely infiltrating the tumor and were more often arranged in small clusters (P=0.010 or as isolated cells (P=0.002 than in large clusters of more than five lymphocytes. No correlation of NY-ESO-1 expression with gender, age, tumor site, ulceration, lymph node sentinel status, or survival was observed. NY-ESO-1 expression in melanoma was associated with tumor progression, including increased tumor thickness, and with reduced tumor infiltrating lymphocytes.

Europe to the stars ESO's first 50 years of exploring the southern sky

CERN Document Server

Schilling, Govert

2012-01-01

The creation of the European Southern Observatory (ESO) in 1962 was the culmination of the dream of leading astronomers from five European countries. Over the years, as more member states joined, ESO constructed the La Silla and Paranal observatories, as well as the Atacama Large Millimeter/submillimeter Array (ALMA) together with partners. ESO is now starting to build the world′s biggest eye on the sky, the European Extremely Large Telescope. At the dawn of 2012, its 50th anniversary year, ESO is ready to enter a new era. One that not even its founding members could have anticipated in their boldest dreams. Constantly at the technological forefront, ESO is ready to tackle new and as yet unimaginable territories of high–precision technology and scientific discovery. Produced especially for ESO′s 50th anniversary, this sumptuously illustrated book takes the reader behind the scenes of the most productive ground–based observatory in the world. It contains the best 300 of ESO′s images, hand–picked fr...

Deep Imaging Search for Planets Forming in the TW Hya Protoplanetary Disk with the Keck/NIRC2 Vortex Coronagraph

Science.gov (United States)

Ruane, G.; Mawet, D.; Kastner, J.; Meshkat, T.; Bottom, M.; Femenía Castellá, B.; Absil, O.; Gomez Gonzalez, C.; Huby, E.; Zhu, Z.; Jenson-Clem, R.; Choquet, É.; Serabyn, E.

2017-08-01

Distinct gap features in the nearest protoplanetary disk, TW Hya (distance of 59.5 ± 0.9 pc), may be signposts of ongoing planet formation. We performed long-exposure thermal infrared coronagraphic imaging observations to search for accreting planets, especially within dust gaps previously detected in scattered light and submillimeter-wave thermal emission. Three nights of observations with the Keck/NIRC2 vortex coronagraph in L‧ (3.4-4.1 μm) did not reveal any statistically significant point sources. We thereby set strict upper limits on the masses of non-accreting planets. In the four most prominent disk gaps at 24, 41, 47, and 88 au, we obtain upper mass limits of 1.6-2.3, 1.1-1.6, 1.1-1.5, and 1.0-1.2 Jupiter masses (M J), assuming an age range of 7-10 Myr for TW Hya. These limits correspond to the contrast at 95% completeness (true positive fraction of 0.95) with a 1% chance of a false positive within 1″ of the star. We also approximate an upper limit on the product of the planet mass and planetary accretion rate of {M}{{p}}\\dot{M}≲ {10}-8 {M}{{J}}2 {{yr}}-1 implying that any putative ˜0.1 M J planet, which could be responsible for opening the 24 au gap, is presently accreting at rates insufficient to build up a Jupiter mass within TW Hya’s pre-main-sequence lifetime.

Implantes dentales para mejorar la biomecánica y estética de la prótesis parcial removible

OpenAIRE

Rengifo Alarcón, Carlos Alberto; Balarezo Razzeto, José Antonio; Matta Morales, Carlos; Vicente Zamudio, Eduardo Gregorio

2014-01-01

Existe un alto porcentaje de la población mundial que presenta algún grado de edentulismo parcial; es por eso que han surgido diferentes alternativas de tratamiento para poder solucionar y dar calidad de vida a estos pacientes. La prótesis parcial removible convencional surgieron en un inicio, para ayudar a estos pacientes, pero presentaban algunos inconvenientes en retención, soporte y estabilidad sobre todo en prótesis dentomucosoportadas, con la introducción de los implantes estos inconven...

The Gaia-ESO Public Spectroscopic Survey

DEFF Research Database (Denmark)

Gilmore, G.; Randich, S.; Asplund, M.

2012-01-01

The Gaia-ESO Public Spectroscopic Survey has begun and will obtain high quality spectroscopy of some 100000 Milky Way stars, in the field and in open clusters, down to magnitude 19, systematically covering all the major components of the Milky Way. This survey will provide the first homogeneous o...

First Giant Mirror for the ESO VLT Ready at REOSC

Science.gov (United States)

1995-11-01

The REOSC Contract In 1989, the European Southern Observatory (ESO), the European Organisation for Astronomy, awarded to REOSC, a subsidiary of the SFIM Group and located in Saint Pierre du Perray (France), a comprehensive contract for the polishing of four 8.2-metre diameter mirrors for the unit telescopes of the ESO Very Large Telescope (VLT) project. These mirrors are the largest ever manufactured and polished. This contract comprises not only the polishing and high-precision optical testing of each giant mirror, but also the safe condition of transportation of the blanks which were manufactured by Schott Glaswerke in Mainz (Germany). In order to fulfill the contract, REOSC conceived, built and equipped a novel, high-tech workshop which would allow to polish and test the mirrors, each of which has a surface area of more than 50 square metres. First 8.2-Metre Mirror is Ready and within Specifications The REOSC polishing facility for giant mirrors was built in Saint Pierre du Perray, just south of Paris. It is equipped with two machines: one for grinding and the other for polishing the mirrors, and both with 150-actuator systems that support the thin and flexible mirrors. All equipment is computer controlled. State-of-the-art interferometers probe the accuracy of the mirror surface as the polishing proceeds; they are installed at the top level of the facility in a 30-metre high tower, at the centre of the mirror's radius of curvature. The success of the work at REOSC is now evident by the fact that careful measurements of the first mirror earlier this month have shown that the final optical surface is correct to within 0.00005 millimetres. For illustration, this corresponds to an accuracy of only 1 millimetre deviation over a surface with a diameter of 165 kilometres (equivalent to the entire Paris area)! ESO Receives the First VLT Mirror After having been carefully placed in a special transport box designed by REOSC, the first mirror blank, weighing 23.5 tons and

The VANDELS ESO public spectroscopic survey

Science.gov (United States)

McLure, R. J.; Pentericci, L.; Cimatti, A.; Dunlop, J. S.; Elbaz, D.; Fontana, A.; Nandra, K.; Amorin, R.; Bolzonella, M.; Bongiorno, A.; Carnall, A. C.; Castellano, M.; Cirasuolo, M.; Cucciati, O.; Cullen, F.; De Barros, S.; Finkelstein, S. L.; Fontanot, F.; Franzetti, P.; Fumana, M.; Gargiulo, A.; Garilli, B.; Guaita, L.; Hartley, W. G.; Iovino, A.; Jarvis, M. J.; Juneau, S.; Karman, W.; Maccagni, D.; Marchi, F.; Mármol-Queraltó, E.; Pompei, E.; Pozzetti, L.; Scodeggio, M.; Sommariva, V.; Talia, M.; Almaini, O.; Balestra, I.; Bardelli, S.; Bell, E. F.; Bourne, N.; Bowler, R. A. A.; Brusa, M.; Buitrago, F.; Caputi, K. I.; Cassata, P.; Charlot, S.; Citro, A.; Cresci, G.; Cristiani, S.; Curtis-Lake, E.; Dickinson, M.; Fazio, G. G.; Ferguson, H. C.; Fiore, F.; Franco, M.; Fynbo, J. P. U.; Galametz, A.; Georgakakis, A.; Giavalisco, M.; Grazian, A.; Hathi, N. P.; Jung, I.; Kim, S.; Koekemoer, A. M.; Khusanova, Y.; Fèvre, O. Le; Lotz, J. M.; Mannucci, F.; Maltby, D. T.; Matsuoka, K.; McLeod, D. J.; Mendez-Hernandez, H.; Mendez-Abreu, J.; Mignoli, M.; Moresco, M.; Mortlock, A.; Nonino, M.; Pannella, M.; Papovich, C.; Popesso, P.; Rosario, D. P.; Salvato, M.; Santini, P.; Schaerer, D.; Schreiber, C.; Stark, D. P.; Tasca, L. A. M.; Thomas, R.; Treu, T.; Vanzella, E.; Wild, V.; Williams, C. C.; Zamorani, G.; Zucca, E.

2018-05-01

VANDELS is a uniquely-deep spectroscopic survey of high-redshift galaxies with the VIMOS spectrograph on ESO's Very Large Telescope (VLT). The survey has obtained ultra-deep optical (0.48 studies. Using integration times calculated to produce an approximately constant signal-to-noise ratio (20 motivation, survey design and target selection.

ESO Observations of New Moon of Jupiter

Science.gov (United States)

2000-08-01

" this object and "secure" its orbit. Recovery of S/1999 J 1 at La Silla Jupiter and its moons would again become visible in the early morning hours in late July with telescopes in the southern hemisphere. By a fortunate coincidence, observing time for observations of comets and asteroids had been allocated to Brett Gladman and his collaborators at two ESO telescopes in exactly this period. Just before sunrise on July 25, he used the Wide Field Imager (WFI) on the MPG/ESO 2.2-m telescope at La Silla to search for S/1999 J 1 . This camera has a comparatively large field-of-view, about 0.5 x 0.5 deg 2 , or about the size of the full moon. This was comfortably larger than the estimated uncertainty in the object's predicted position at the time of the observation. And indeed, S/1999 J 1 was spotted not too far from that location, weakly visible in the glare of the nearby waning moon. Detailed observations of S/1999 J 1 at Paranal Only three days later, in the early morning hours of July 28, the small object was again imaged, this time from the 8.2-m VLT ANTU telescope at Paranal. Brett Gladman and Hermann Boehnhardt , now knowing exactly where to look in the sky, used the FORS-1 multi-mode instrument to obtain exposures of S/1999 J 1 through several optical filters. The great light-collecting power of this telescope resulted in excellent images while S/1999 J 1 was moving across the sky, cf. PR Photos 19a-b/00 . These observations definitively confirmed the "recovery" of the object and also provided an accurate determination of its brightness and colour, cf. IAU Circular 7472 , published on August 3. From accurate positional measurements on these exposures and the earlier ones from La Silla, Gareth Williams of the Minor Planet Center was able to substantially improve the computation of the orbit of S/1999 J 1 around Jupiter. It was found ( IAU Circular 7469 ) to move in a somewhat elliptical orbit around Jupiter with a period of just over 2 years (768 days) and at a mean

Radio-continuum jets around the peculiar galaxy pair ESO 295-IG022

Directory of Open Access Journals (Sweden)

Filipović M.D.

2010-01-01

Full Text Available We report new radio-continuum observations with the Australia Telescope Compact Array (ATCA of the region surrounding the peculiar galaxy pair ESO 295-IG022 at the centre of the poor cluster Abell S0102. We observed this cluster at wavelengths of λ=20/13 and 6/3 cm with the ATCA 6 km array. With these configurations, we achieved a resolution of ~2'' at 3 cm which is sufficient to resolve the jet-like structure of ~3' length detected at 20 cm. From our new high resolution images at 6 and 3 cm we confirm the presence of a double jet structure, most likely originating from the northern galaxy (ESO 295-IG022-N, bent and twisted towards the south. We found the spectral index of the jet to be very steep (α=-1.32. No point source was detected that could be associated with the core of ESO 295-IG022-N. On the other hand, ESO 295-IG022-S does not show any jet structure, but does show a point radio source. This source has variable flux and spectral index, and appears to be superposed on the line-of-sight of the jets (seen at 20-cm originating from the northern galaxy ESO 295-IG022-N. Finally, regions of very high and somewhat well ordered polarization were detected at the level of 70%.

A psf-fitting pipeline for VVV-ESO: The star cluster Pismis 24

Science.gov (United States)

Dias, R. A. G.; Bonatto, C.

2014-10-01

Este trabalho apresenta um algoritmo para a extração de dados fotométricos do catálogo "VISTA Variables in the Via Láctea" (VVV) do ESO. A principal característica do algoritmo é evitar a interação com o usuário mantendo precisão e profundidade fotométrica, de fato o algoritmo foi capaz de gerar dados mais precisos para as estrelas menos brilhantes (J gtrsim 16, H gtrsim 15,5 e H gtrsim 15) e confiável fotometria para estrelas mais de uma magnitude mais fracas do que as detectáveis com outras técnicas. Embora o algoritmo obtenha resultados menos precisos para as estrelas mais brilhantes, este provou ser o método mais adequado, uma vez que queremos trabalhar com aglomerados abertos jovens, onde a pré-sequência principal é de maior importância. Além disso, podemos combinar 2MASS e VVV para substituir as estrelas saturadas do VVV.

The AstroMundus-ESO Connection

Science.gov (United States)

Humphreys, E.; Hussain, G.; Biggs, A.; Lu, H.-Y.; Emsellem, E.; De Cia, A.; Lavail, A.; Spyromilio, J.

2016-03-01

The AstroMundus Programme is an E+ Erasmus Mundus Joint Masters Degree course in astronomy and astrophysics offered by a consortium of European universities and research institutes. In 2014 and 2016, AstroMundus Masters students visited ESO and participated in proposal-writing sessions, during which groups of students speed-wrote complete ALMA proposals, before presenting them to a pseudo Time Allocation Committee providing on-the-spot feedback. The AstroMundus visit of 25-26 January 2016 is described.

NASA and ESA astronauts visit ESO. Hubble repair team meets European astronomers in Garching.

Science.gov (United States)

1994-02-01

On Wednesday, February 16, 1994, seven NASA and ESA astronauts and their spouses will spend a day at the Headquarters of the European Southern Observatory. They are the members of the STS-61 crew that successfully repaired the Hubble Space Telescope during a Space Shuttle mission in December 1993. This will be the only stop in Germany during their current tour of various European countries. ESO houses the Space Telescope European Coordinating Facility (ST/ECF), a joint venture by the European Space Agency and ESO. This group of astronomers and computer specialists provide all services needed by European astronomers for observations with the Space Telescope. Currently, the European share is about 20 of the total time available at this telescope. During this visit, a Press Conference will be held on Wednesday, February 16, 11:45 - 12:30 at the ESO Headquarters Karl-Schwarzschild-Strasse 2 D-85748 Garching bei Munchen. Please note that participation in this Press Conference is by invitation only. Media representatives may obtain invitations from Mrs. E. Volk, ESO Information Service at this address (Tel.: +49-89-32006276; Fax.: +49-89-3202362), until Friday, February 11, 1994. After the Press Conference, between 12:30 - 14:00, a light refreshment will be served at the ESO Headquarters to all participants. >From 14:00 - 15:30, the astronauts will meet with students and teachers from the many scientific institutes in Garching in the course of an open presentation at the large lecture hall of the Physics Department of the Technical University. It is a 10 minute walk from ESO to the hall. Later the same day, the astronauts will be back at ESO for a private discussion of various space astronomy issues with their astronomer colleagues, many of whom are users of the Hubble Space Telescope, as well as ground-based telescopes at the ESO La Silla Observatory and elsewhere. The astronauts continue to Switzerland in the evening.

Strategy for monitoring T cell responses to NY-ESO-1 in patients with any HLA class I allele

Science.gov (United States)

Gnjatic, Sacha; Nagata, Yasuhiro; Jäger, Elke; Stockert, Elisabeth; Shankara, Srinivas; Roberts, Bruce L.; Mazzara, Gail P.; Lee, Sang Yull; Dunbar, P. Rod; Dupont, Bo; Cerundolo, Vincenzo; Ritter, Gerd; Chen, Yao-Tseng; Knuth, Alexander; Old, Lloyd J.

2000-01-01

NY-ESO-1 elicits frequent antibody responses in cancer patients, accompanied by strong CD8+ T cell responses against HLA-A2-restricted epitopes. To broaden the range of cancer patients who can be assessed for immunity to NY-ESO-1, a general method was devised to detect T cell reactivity independent of prior characterization of epitopes. A recombinant adenoviral vector encoding the full cDNA sequence of NY-ESO-1 was used to transduce CD8-depleted peripheral blood lymphocytes as antigen-presenting cells. These modified antigen-presenting cells were then used to restimulate memory effector cells against NY-ESO-1 from the peripheral blood of cancer patients. Specific CD8+ T cells thus sensitized were assayed on autologous B cell targets infected with a recombinant vaccinia virus encoding NY-ESO-1. Strong polyclonal responses were observed against NY-ESO-1 in antibody-positive patients, regardless of their HLA profile. Because the vectors do not cross-react immunologically, only responses to NY-ESO-1 were detected. The approach described here allows monitoring of CD8+ T cell responses to NY-ESO-1 in the context of various HLA alleles and has led to the definition of NY-ESO-1 peptides presented by HLA-Cw3 and HLA-Cw6 molecules. PMID:11005863

Los hospitales de soporte combativo para la práctica quirúrgica contemporánea en escenarios de acciones combativas

OpenAIRE

Velázquez Pupo, Alejandro; Martínez Alvarado, Miguel Vicente; Escalona Blanchey, Yanet; Menéndez López, José Rogelio

2016-01-01

Las demandas de la práctica quirúrgica contemporánea en los escenarios de acciones combativas crecen tanto por la cantidad de las heridas de guerra que ameritan una intervención quirúrgica, como por la calidad y destrucción que los agentes vulnerantes contemporáneos disponibles producen. Eso provoca que los servicios médicos procuren proporcionar buenas prácticas quirúrgicas en los escenarios más hostiles imaginables. Para ello, fue necesario dotar a las instituciones médicas desplegadas de u...

New Parallaxes and a Convergence Analysis for the TW Hya Association

Science.gov (United States)

Donaldson, J. K.; Weinberger, A. J.; Gagné, J.; Faherty, J. K.; Boss, A. P.; Keiser, S. A.

2016-12-01

The TW Hya Association (TWA) is a nearby stellar association with an age of ˜5-10 Myr. This is an important age for studying the late stages of star and planet formation. We measure the parallaxes of 14 candidate members of TWA. That brings to 38 the total number of individual stars with fully measured kinematics, I.e., proper motion, radial velocity, and parallax, to describe their motions through the Galaxy. We analyze these kinematics to search for convergence to a smaller volume in the past, but we find that the association is never much more compact than it is at present. We show that it is difficult to measure traceback ages for associations such as TWA that have expected velocity dispersions of 1-2 km s-1 with typical measurement uncertainties. We also use our stellar distances and pre-main-sequence evolutionary tracks to find the average age of the association of 7.9 ± 1.0 Myr. Additionally, our parallax measurement of TWA 32 indicates that it should be considered a bona fide member of TWA. Two new candidate members have high membership probabilities, and we assign them TWA numbers: TWA 45 for 2MASS J11592786-4510192 and TWA 46 for 2MASS J12354615-4115531.

Shaping ESO2020+ Together: Feedback from the Community Poll

Czech Academy of Sciences Publication Activity Database

Primas, F.; Ivison, R.; Berger, J.-P.; Caselli, P.; De Gregorio-Monsalvo, I.; Alonso Herrero, A.; Knudsen, K.K.; Leibundgut, B.; Moitinho, A.; Saviane, I.; Spyromilio, J.; Testi, L.; Vennes, Stephane

2015-01-01

Roč. 161, September (2015), s. 6-14 ISSN 0722-6691 Institutional support: RVO:67985815 Keywords : ESO * observing programmes * data archiving Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics

A novel murine T-cell receptor targeting NY-ESO-1.

Science.gov (United States)

Rosati, Shannon F; Parkhurst, Maria R; Hong, Young; Zheng, Zhili; Feldman, Steven A; Rao, Mahadev; Abate-Daga, Daniel; Beard, Rachel E; Xu, Hui; Black, Mary A; Robbins, Paul F; Schrump, David A; Rosenberg, Steven A; Morgan, Richard A

2014-04-01

Cancer testis antigens, such as NY-ESO-1, are expressed in a variety of prevalent tumors and represent potential targets for T-cell receptor (TCR) gene therapy. DNA encoding a murine anti-NY-ESO-1 TCR gene (mTCR) was isolated from immunized HLA-A*0201 transgenic mice and inserted into a γ-retroviral vector. Two mTCR vectors were produced and used to transduce human PBL. Transduced cells were cocultured with tumor target cell lines and T2 cells pulsed with the NY-ESO-1 peptide, and assayed for cytokine release and cell lysis activity. The most active TCR construct was selected for production of a master cell bank for clinical use. mTCR-transduced PBL maintained TCR expression in short-term and long-term culture, ranging from 50% to 90% efficiency 7-11 days after stimulation and 46%-82% 10-20 days after restimulation. High levels of interferon-γ secretion were observed (1000-12000 pg/mL), in tumor coculture assays and recognition of peptide-pulsed cells was observed at 0.1 ng/mL, suggesting that the new mTCR had high avidity for antigen recognition. mTCR-transduced T cells also specifically lysed human tumor targets. In all assays, the mTCR was equivalent or better than the comparable human TCR. As the functional activity of TCR-transduced cells may be affected by the formation of mixed dimers, mTCRs, which are less likely to form mixed dimers with endogenous hTCRs, may be more effective in vivo. This new mTCR targeted to NY-ESO-1 represents a novel potential therapeutic option for adoptive cell-transfer therapy for a variety of malignancies.

Europe's Astronomy Teachers Meet at ESO

Science.gov (United States)

1994-12-01

European Association for Astronomy Education Formed A joint EU/ESO Workshop (1) on the Teaching of Astronomy in Europe was held at the ESO Headquarters from November 25-30, 1994, under the auspices of the 1994 European Week for Scientific Culture. More than 100 teachers from secondary schools in 17 European countries participated together with representatives of national ministries and local authorities, as well as professional astronomers. This meeting was the first of its kind ever held and was very successful. As a most visible and immediate outcome, the participants agreed to form the "European Association for Astronomy Education (EAAE)", uniting astronomy educators all over Europe into one network. A provisional Executive Committee of the EAAE was elected which will work towards the organisation of a constitutional conference within the next year. The participants unanimously adopted a "Declaration on the Teaching of Astronomy in Europe", specifying the overall aims and initial actions needed to achieve them. Astronomy: Science, Technology and Culture At the beginning of the Workshop the participants listened to lectures by several specialists about some of the most active fields of astronomy. The scientific sessions included topics as diverse as minor bodies in the solar system, nucleosynthesis, interstellar chemistry and cosmology. Then followed overviews of various recent advances in astronomical technology, some of which are already having direct impact on highly specialized sectors of European industry. They included the advanced use of computers in astronomy, for instance within image processing and data archiving, as well as a demonstration of remote observing. Discussing the cultural aspects, Nigel Calder (UK) and Hubert Reeves (France) emphasized the important role of astronomy in modern society, in particular its continuing influence on our perceptions of mankind's unique location in time and space. Teaching of Astronomy in European Countries

Britain Approaches ESO about Installation of Major New Telescope at Paranal

Science.gov (United States)

2000-02-01

The Executive Board of the UK Visible and Infrared Survey Telescope (VISTA) project announced today [1] that it is aiming at the installation of a new and powerful astronomical telescope at the ESO Paranal Observatory (Chile). This 4-metre telescope is a specialised wide-angle facility equipped with powerful cameras and efficient detectors that will enable it to obtain deep images of large sky areas in short time. These survey observations will be made in several wavebands in the optical and, in particular, the near-infrared region of the electromagnetic spectrum. VISTA will become the largest and most effective telescope of its type when it enters into operation in 2004. It is a project of a consortium of 18 UK universities [2]. Construction is expected to start in spring 2000. Funding of the project was announced in May 1999, as one of the first allocations from the "Joint Infrastructure Fund (JIF)", an initiative of the UK Government's Department of Trade and Industry, the Wellcome Trust, and the Higher Education Funding Council for England. ESO's Director General, Dr. Catherine Cesarsky , is very pleased with this decision. She received a mandate from the ESO Council in December 1999 to negotiate a contract with the UK Particle Physics and Astronomy Research Council (PPARC) , acting on behalf of the VISTA Executive Board, for the installation of VISTA at Paranal and now looks forward to settle the associated legal and operational details with her British counterparts at good pace. "The installation of VISTA at Paranal will be of great benefit to all European astronomers", she says. "The placement of a survey telescope of this size next to ESO's VLT, the world's largest optical telescope, opens a plethora of exciting opportunities for joint research projects. Deep observations with VISTA, especially in infrared wavebands, will provide a most valuable, first census of large regions of space. This will most certainly lead to the discoveries of many new and

ESO & NOT photometric monitoring of the Cloverleaf quasar

NARCIS (Netherlands)

Ostensen, R; Remy, M; Lindblad, PO; Refsdal, S; Stabell, R; Surdej, J; Barthel, PD; Emanuelsen, PI; Festin, L; Gosset, E; Hainaut, O; Hakala, P; Hjelm, M; Hjorth, J; Hutsemekers, D; Jablonski, M; Kaas, AA; Kristen, H; Larsson, S; Magain, P; Pettersson, B; Pospieszalska-Surdej, A; Smette, A; Teuber, J; Thomsen, B; Van Drom, E

1997-01-01

The Cloverleaf quasar, H1413+117, has been photometrically monitored at ESO (La Silla, Chile) and with the NOT (La Palma, Spain) during the period 1987-1994. All good quality CCD frames have been successfully analysed using two independent methods (i.e. an automatic image decomposition technique and

The ESO Observing Programmes Committee

Science.gov (United States)

Westerlund, B. E.

1982-06-01

Since 1978 the ESO Observing Programmes Committee (OPC) has "the function to inspect and rank the proposals made for observing programmes at La Silla, and thereby to advise the Director General on the distribution of observing time". The members (one from each member country) and their alternates are nominated by the respective national committees for five-year terms (not immediately renewable). The terms are staggered so that each year one or two persons are replaced. The Chairman is appointed annually by the Council. He is invited to attend Council meetings and to report to its members.

La Investigación en Educación Matemática y Práctica Pedagógica, perspectiva de Licenciados en matemáticas en formación.

Directory of Open Access Journals (Sweden)

Robinson Junior Conde Carmona

2017-12-01

que no se sienten con las suficientes competencias para hacer un trabajo de investigación, además de eso no ven necesario tenerlas porque no consideran la investigación un componente importante dentro de sus práctica pedagógica.

The ESO Scientific and Technical Committee.

Science.gov (United States)

Léna, P.

1982-03-01

Since 1978, the structure of ESO involves a Scientific and Technical Committee (STC) which advises the Council on scientific and technical matters. This committee meets twice a year, usually at Garehing; its members are nominated by the Council and their term is 4 years. The STC has 10 members, who are as evenly distributed as possible among member countries, although indeed mainly chosen for their scientific abilities. The chairman is invited to attend Council meetings and to report to the members.

Avaliação pré-operatória do pneumopata Evaluación pré-operatoria del pneumopata Preoperative assessment of lung disease patients

Directory of Open Access Journals (Sweden)

Gilson Ramos

2003-02-01

Full Text Available JUSTIFICATIVA E OBJETIVOS: As complicações pulmonares são as causas mais freqüentes de morbimortalidade pós-operatória, especialmente nos pneumopatas. Por essa razão, esses pacientes devem ser criteriosamente avaliados e preparados no pré-operatório, tanto do ponto de vista clínico como laboratorial. O objetivo da presente revisão é determinar o risco cirúrgico e estabelecer condutas pré-operatórias para minimizar a morbimortalidade per e pós-operatórias, nos portadores de doenças respiratórias. CONTEÚDO: As principais repercussões do ato anestésico-cirúrgico na função pulmonar foram relatadas. Da mesma forma, procurou-se selecionar os pacientes de maior risco, envolvidos ou não em ressecção pulmonar. Para esse fim, utilizou-se da propedêutica clínica e laboratorial. Finalmente, foi apresentada uma proposta de algoritmo pré-operatório para os procedimentos com ressecção pulmonar. CONCLUSÕES: O portador de doença respiratória, especialmente as de evolução crônica, necessita ser rigorosamente avaliado no pré-operatório. A classificação do estado físico (ASA e o índice de Goldman são fatores de previsão de risco importantes nos pneumopatas não-candidatos à ressecção pulmonar. Somando-se a esses critérios, nos candidatos à ressecção pulmonar, o VO2 max, o VEF1e capacidade de difusão estimados para o pós-operatório, são imprescindíveis, em algumas situações. Os beta2-agonistas e corticóides devem ser considerados nos pré-operatórios desses pacientes.JUSTIFICATIVA Y OBJETIVOS: Las complicaciones pulmonares son las causas más frecuentes de morbi-mortalidad pós-operatoria, especialmente en los pneumopatas. Por esa razón, esos pacientes deben ser criteriosamente evaluados y preparados en el pré-operatorio, tanto del punto de vista clínico como laboratorial. El objetivo de la presente revisión es determinar el riesgo quirúrgico y establecer conductas pré-operatorias para minimizar

A Gaia DR2 Confirmation that 2MASS J12074836–3900043 is a Member of the TW HYA Association

Science.gov (United States)

Gagné, Jonathan; Gonzales, Eileen C.; Faherty, Jacqueline K.

2018-05-01

We use new data from Gaia DR2 to confirm that the young L1 $\\gamma$ candidate member of the TW Hya association (TWA) is now a bona fide member with a model-dependent mass estimate of ~15 $M_{Jup}$. The ambiguous M9 $\\gamma$ candidate member 2MASS J12474428---3816464 also gets a higher Bayesian membership probability for TWA membership as a result of Gaia DR2 data and a new radial velocity measurement, but it remains unclear whether it is a true member of TWA or if it is an unrelated young interloper, because it is separated by 4.6 km/s from the locus of TWA members in UVW space.

The 0.5 micrometer-2.2 micrometer Scattered Light Spectrum of the Disk Around TW Hya

Science.gov (United States)

Debes, John H.; Jang-Condell, Hannah; Weinberger, Alycia J.; Roberg, Aki; Schneider, Glenn

2012-01-01

We present a 0.5-2.2micron scattered light spectrum of the circumstellar disk around TW Hya from a combination of spatially resolved HST STIS spectroscopy and NICMOS coronagraphic images of the disk. \\Ve investigate the morphology at the disk at distances> 40 AU over this wide range of wavelengths. We measure the surface brightness, azimuthal symmetry, and spectral character of the disk as a function of radius. We find that the scattering efficiency of the dust is largely neutral to blue over the observed wavelengths. We find a good fit to the data over a wide range of distances from the star if we use a model disk with a partial gap of 30% depth at 80 AU and with steep disk truncation exterior to 100 AU. If the gap is caused by a planetary companion in the process of accreting disk gas, it must be less than 20 Solar mass.

CERN, ESA and ESO Launch "Physics On Stage"

Science.gov (United States)

2000-03-01

Physics is everywhere . The laws of physics govern the Universe, the Sun, the Earth and even our own lives. In today's rapidly developing society, we are becoming increasingly dependent on high technology - computers, transport, and communication are just some of the key areas that are the result of discoveries by scientists working in physics. But how much do the citizens of Europe really know about physics? Here is a unique opportunity to learn more about this elusive subject! [Go to Physics On Stage Website] Beginning in February 2000, three major European research organisations are organising a unique Europe-wide programme to raise the public awareness of physics and related sciences. "Physics on Stage" is launched by the European Laboratory for Particle Physics (CERN) , the European Space Agency (ESA) and the European Southern Observatory (ESO) , with support from the European Union. Other partners are the European Physical Society (EPS) and the European Association for Astronomy Education (EAAE). This exciting programme is part of the European Week for Science and Technology and will culminate in a Science Festival during November 6-11, 2000, on the CERN premises at the French-Swiss border near Geneva. Why "Physics on Stage"? The primary goal of "Physics on Stage" is to counteract the current decline in interest and knowledge about physics among Europe's citizens by means of a series of highly visible promotional activities. It will bring together leading scientists and educators, government bodies and the media, to confront the diminishing attraction of physics to young people and to develop strategies to reverse this trend. The objective in the short term is to infuse excitement and to provide new educational materials. In the longer term, "Physics on Stage" will generate new developments by enabling experts throughout Europe to meet, exchange and innovate. "Physics on Stage" in 22 European Countries "Physics on Stage" has been initiated in 22 European

ESO unveils an amazing, interactive, 360-degree panoramic view of the entire night sky

Science.gov (United States)

2009-09-01

The first of three images of ESO's GigaGalaxy Zoom project - a new magnificent 800-million-pixel panorama of the entire sky as seen from ESO's observing sites in Chile - has just been released online. The project allows stargazers to explore and experience the Universe as it is seen with the unaided eye from the darkest and best viewing locations in the world. This 360-degree panoramic image, covering the entire celestial sphere, reveals the cosmic landscape that surrounds our tiny blue planet. This gorgeous starscape serves as the first of three extremely high-resolution images featured in the GigaGalaxy Zoom project, launched by ESO within the framework of the International Year of Astronomy 2009 (IYA2009). GigaGalaxy Zoom features a web tool that allows users to take a breathtaking dive into our Milky Way. With this tool users can learn more about many different and exciting objects in the image, such as multicoloured nebulae and exploding stars, just by clicking on them. In this way, the project seeks to link the sky we can all see with the deep, "hidden" cosmos that astronomers study on a daily basis. The wonderful quality of the images is a testament to the splendour of the night sky at ESO's sites in Chile, which are the most productive astronomical observatories in the world. The plane of our Milky Way Galaxy, which we see edge-on from our perspective on Earth, cuts a luminous swath across the image. The projection used in GigaGalaxy Zoom place the viewer in front of our Galaxy with the Galactic Plane running horizontally through the image - almost as if we were looking at the Milky Way from the outside. From this vantage point, the general components of our spiral galaxy come clearly into view, including its disc, marbled with both dark and glowing nebulae, which harbours bright, young stars, as well as the Galaxy's central bulge and its satellite galaxies. The painstaking production of this image came about as a collaboration between ESO, the renowned

New Paranal Views

Science.gov (United States)

2001-01-01

Last year saw very good progress at ESO's Paranal Observatory , the site of the Very Large Telescope (VLT). The third and fourth 8.2-m Unit Telescopes, MELIPAL and YEPUN had "First Light" (cf. PR 01/00 and PR 18/00 ), while the first two, ANTU and KUEYEN , were busy collecting first-class data for hundreds of astronomers. Meanwhile, work continued towards the next phase of the VLT project, the combination of the telescopes into the VLT Interferometer. The test instrument, VINCI (cf. PR 22/00 ) is now being installed in the VLTI Laboratory at the centre of the observing platform on the top of Paranal. Below is a new collection of video sequences and photos that illustrate the latest developments at the Paranal Observatory. The were obtained by the EPR Video Team in December 2000. The photos are available in different formats, including "high-resolution" that is suitable for reproduction purposes. A related ESO Video News Reel for professional broadcasters will soon become available and will be announced via the usual channels. Overview Paranal Observatory (Dec. 2000) Video Clip 02a/01 [MPEG - 4.5Mb] ESO PR Video Clip 02a/01 "Paranal Observatory (December 2000)" (4875 frames/3:15 min) [MPEG Video+Audio; 160x120 pix; 4.5Mb] [MPEG Video+Audio; 320x240 pix; 13.5 Mb] [RealMedia; streaming; 34kps] [RealMedia; streaming; 200kps] ESO Video Clip 02a/01 shows some of the construction activities at the Paranal Observatory in December 2000, beginning with a general view of the site. Then follow views of the Residencia , a building that has been designed by Architects Auer and Weber in Munich - it integrates very well into the desert, creating a welcome recreational site for staff and visitors in this harsh environment. The next scenes focus on the "stations" for the auxiliary telescopes for the VLTI and the installation of two delay lines in the 140-m long underground tunnel. The following part of the video clip shows the start-up of the excavation work for the 2.6-m VLT Survey

Treatment with 5-Aza-2'-Deoxycytidine Induces Expression of NY-ESO-1 and Facilitates Cytotoxic T Lymphocyte-Mediated Tumor Cell Killing.

Directory of Open Access Journals (Sweden)

Agnes S Klar

Full Text Available NY-ESO-1 belongs to the cancer/testis antigen (CTA family and represents an attractive target for cancer immunotherapy. Its expression is induced in a variety of solid tumors via DNA demethylation of the promoter of CpG islands. However, NY-ESO-1 expression is usually very low or absent in some tumors such as breast cancer or multiple myeloma. Therefore, we established an optimized in vitro treatment protocol for up-regulation of NY-ESO-1 expression by tumor cells using the hypomethylating agent 5-aza-2'-deoxycytidine (DAC.We demonstrated de novo induction of NY-ESO-1 in MCF7 breast cancer cells and significantly increased expression in U266 multiple myeloma cells. This effect was time- and dose-dependent with the highest expression of NY-ESO-1 mRNA achieved by the incubation of 10 μM DAC for 72 hours. NY-ESO-1 activation was also confirmed at the protein level as shown by Western blot, flow cytometry, and immunofluorescence staining. The detection and quantification of single NY-ESO-1 peptides presented at the tumor cell surface in the context of HLA-A*0201 molecules revealed an increase of 100% and 50% for MCF7 and U266 cells, respectively. Moreover, the enhanced expression of NY-ESO-1 derived peptides at the cell surface was accompanied by an increased specific lysis of MCF7 and U266 cells by HLA-A*0201/NY-ESO-1(157-165 peptide specific chimeric antigen receptor (CAR CD8+ T cells. In addition, the killing activity of CAR T cells correlated with the secretion of higher IFN-gamma levels.These results indicate that NY-ESO-1 directed immunotherapy with specific CAR T cells might benefit from concomitant DAC treatment.

libros de texto de 3° de la eso?*

Directory of Open Access Journals (Sweden)

Sergio Montañés Bayonas

2015-01-01

Full Text Available El presente estudio centra su atención sobre como los libros de texto abordan las diferentes problemáticas ambientales en la ESO, ya que se trata de un recurso importante utilizado por la mayoría de los profesores. Se parte de las orientaciones metodológicas propuestas desde el ámbito de la investigación educativa en Educación para la Sostenibilidad. El análisis se ha realizado en los temas sobre problemas ambientales presentes en los libros de 3° de ESO. El estudio incluye indagar sobre los contenidos, el papel de las ilustraciones y las actividades. Nos ha interesado conocer si las ilustraciones facilitan la comprensión de los contenidos y si las actividades propuestas podrían fomentar cambios en sus valores, actitudes y comportamientos. Los resultados indican que los libros de texto son mejorables y en general, abordan la crisis ambiental global desde planteamientos educativos tradicionales caracterizados por contenidos excesivamente teóricos, simplificadores y reduccionistas.

TNO Photometry and Spectroscopy at ESO and Calar Alto

Science.gov (United States)

Boehnhardt, H.; Sekiguchi, T.; Vair, M.; Hainaut, O.; Delahodde, C.; West, R. M.; Tozzi, G. P.; Barrera, L.; Birkle, K.; Watanabe, J.; Meech, K.

New photometry and spectroscopy of Transneptunian objects (TNO) has been obtained at ESO (VLT+FORS1, NTT+SOFI) and the Calar Alto (3.5m+MOSCA) observatory. BVRI photometry of more than 10 objects confirms the general colour-colour distribution of TNOs found previously. Quasi-simultaneous spectroscopy in the visible wavelength range of 5 TNOs did not reveal any spectral signature apart from the spetral gradients which are in agreement with the broadband colours. JHK filter photometry of 3 objects indicates that the reddening may only occur in the near-IR at least in some cases. Using new observations from the ESO VLT the lightcurve, colours and spectrum of 1996TO66 are investigated: the rotation period of 6.25h is confirmed, also the change in the lightcurve between 1997 and 1998 which indicates an exceptional behaviour in this object (temporary cometary activity ?). The 1999 photometry and spectroscopy in the visible revealed solar colours, no reddening and no spectral features. V-R colour changes over the rotation phase are not found. This works is done in colaboration with:

Immunohistochemical assessment of NY-ESO-1 expression in esophageal adenocarcinoma resection specimens.

Science.gov (United States)

Hayes, Stephen J; Hng, Keng Ngee; Clark, Peter; Thistlethwaite, Fiona; Hawkins, Robert E; Ang, Yeng

2014-04-14

To assess NY-ESO-1 expression in a cohort of esophageal adenocarcinomas. A retrospective search of our tissue archive for esophageal resection specimens containing esophageal adenocarcinoma was performed, for cases which had previously been reported for diagnostic purposes, using the systematised nomenclature of human and veterinary medicine coding system. Original haematoxylin and eosin stained sections were reviewed, using light microscopy, to confirm classification and tumour differentiation. A total of 27 adenocarcinoma resection specimens were then assessed using immunohistochemistry for NY-ESO-1 expression: 4 well differentiated, 14 moderately differentiated, 4 moderate-poorly differentiated, and 5 poorly differentiated. Four out of a total of 27 cases of esophageal adenocarcinoma examined (15%) displayed diffuse cytoplasmic and nuclear expression for NY-ESO-1. They displayed a heterogeneous and mosaic-type pattern of diffuse staining. Diffuse cytoplasmic staining was not identified in any of these structures: stroma, normal squamous epithelium, normal submucosal gland and duct, Barrett's esophagus (goblet cell), Barrett's esophagus (non-goblet cell) and high grade glandular dysplasia. All adenocarcinomas showed an unexpected dot-type pattern of staining at nuclear, paranuclear and cytoplasmic locations. Similar dot-type staining, with varying frequency and size of dots, was observed on examination of Barrett's metaplasia, esophageal submucosal gland acini and the large bowel negative control, predominantly at the crypt base. Furthermore, a prominent pattern of apical (luminal) cytoplasmic dot-type staining was observed in some cases of Barrett's metaplasia and also adenocarcinoma. A further morphological finding of interest was noted on examination of haematoxylin and eosin stained sections, as aggregates of lymphocytes were consistently noted to surround submucosal glands. We have demonstrated for the first time NY-ESO-1 expression by esophageal

ESO and Fokker Space Sign Contract about VLTI Delay Line

Science.gov (United States)

1998-03-01

The European Southern Observatory is building the world's largest optical telescope, the Very Large Telescope (VLT) , at the ESO Paranal Observatory in Chile. The VLT consists of four 8.2-m unit telescopes and several smaller, moveable Auxiliary Telescopes. When coupled as the giant VLT Interferometer (VLTI) , they will together provide the sharpest images ever obtained by any optical telescope. It will in principle be able to see an astronaut on the surface of the Moon, 400,000 km away. The VLTI Delay Lines Fokker Space (Leiden, The Netherlands) has been awarded a contract for the delivery of the Delay Line of the VLTI. This is a mechanical-optical system that will compensate the optical path differences of the light beams from the individual telescopes. Such a system is necessary to ensure that the light from all telescopes arrive in the same phase at the focal point of the interferometer. Otherwise, the very sharp interferometric images cannot be obtained. ESO PR Photo 08/98 [JPEG, 102k] Schematic representation of the VLTI Delay Line, showing the retro-reflector on its moving base. For more details, please consult the technical explanation below. This highly accurate system will be developed in close co-operation with the Dutch institute TNO-TPD (Netherlands Organization for Applied Scientific Research - Institute of Applied Physics) . The most innovative feature of the Delay Line is the new control strategy, a two-stage control system, based on linear motor technology, combined with high accuracy piezo-electric control elements. This enables the system to position the so-called cat's eye reflector system with an accuracy of only a few nanometers (millionth of a millimetre (nm)) over a stroke length of 60 metres. Within radio astronomy, interferometric techniques have been applied by Dutch astronomers since many years. They will now be able to contribute with their extensive knowledge of such systems to the next generation of astronomical interferometric

Prácticas, representaciones y discursos de corporalidad. La ambigüedad en los cuerpos circenses

Directory of Open Access Journals (Sweden)

Julieta Infantino

2010-07-01

Full Text Available En este artículo trabajaremos con las prácticas de los artistas circenses contemporáneos en la ciudad de Buenos Aires. Abordaremos los modos en los que la corporalidad se constituye en uno de los medios de expresión identitaria en tanto un grupo social puede componer, a través de sus experiencias corporales, sus propios estilos artísticos, su propia definición de práctica artístico-laboral, su propio cuerpo legítimo. Mostraremos la manera en que esos cuerpos pueden por momentos disputar y/o reproducir concepciones hegemónicas de corporalidad, proponiendo la necesidad de pensar estos procesos de manera dinámica, prestando atención tanto a los mecanismos de poder como a su contraparte, los sujetos que negocian, cuestionan y/o resisten.

De la literatura misógina medieval a la igualdad de oportunidades entre hombres y mujeres. Descripción de una unidad didáctica para 3º de la ESO

OpenAIRE

Bataller Català, Alexandre

2009-01-01

Se explica y comenta los contenidos y secuenciación de una unidad didáctica que contiene como tema transversal la igualdad de oportunidades entre homes y mujeres, preparada para la asignatura de "Valencià. Llengua i literatura" para el curso de 3º de la ESO (que hemos publicado dentro de un proyecto editorial, Ediciones SM, 2007). Los contenidos literarios, tanto teóricos como prácticos, tratan tanto de la obra más celebrada de temática misógina del siglo XV, la novela en verso l'Spill, escri...

ESO Signs Largest-Ever European Industrial Contract For Ground-Based Astronomy Project ALMA

Science.gov (United States)

2005-12-01

ESO, the European Organisation for Astronomical Research in the Southern Hemisphere, announced today that it has signed a contract with the consortium led by Alcatel Alenia Space and composed also of European Industrial Engineering (Italy) and MT Aerospace (Germany), to supply 25 antennas for the Atacama Large Millimeter Array (ALMA) project, along with an option for another seven antennas. The contract, worth 147 million euros, covers the design, manufacture, transport and on-site integration of the antennas. It is the largest contract ever signed in ground-based astronomy in Europe. The ALMA antennas present difficult technical challenges, since the antenna surface accuracy must be within 25 microns, the pointing accuracy within 0.6 arc seconds, and the antennas must be able to be moved between various stations on the ALMA site. This is especially remarkable since the antennas will be located outdoor in all weather conditions, without any protection. Moreover, the ALMA antennas can be pointed directly at the Sun. ALMA will have a collecting area of more than 5,600 square meters, allowing for unprecedented measurements of extremely faint objects. The signing ceremony took place on December 6, 2005 at ESO Headquarters in Garching, Germany. "This contract represents a major milestone. It allows us to move forward, together with our American and Japanese colleagues, in this very ambitious and unique project," said ESO's Director General, Dr. Catherine Cesarsky. "By building ALMA, we are giving European astronomers access to the world's leading submillimetre facility at the beginning of the next decade, thereby fulfilling Europe's desire to play a major role in this field of fundamental research." Pascale Sourisse, Chairman and CEO of Alcatel Alenia Space, said: "We would like to thank ESO for trusting us to take on this new challenge. We are bringing to the table not only our recognized expertise in antenna development, but also our long-standing experience in

Recombinant Lactobacillus plantarum induces immune responses to cancer testis antigen NY-ESO-1 and maturation of dendritic cells

Science.gov (United States)

Mobergslien, Anne; Vasovic, Vlada; Mathiesen, Geir; Fredriksen, Lasse; Westby, Phuong; Eijsink, Vincent GH; Peng, Qian; Sioud, Mouldy

2015-01-01

Given their safe use in humans and inherent adjuvanticity, Lactic Acid Bacteria may offer several advantages over other mucosal delivery strategies for cancer vaccines. The objective of this study is to evaluate the immune responses in mice after oral immunization with Lactobacillus (L) plantarum WCFS1 expressing a cell-wall anchored tumor antigen NY-ESO-1. And to investigate the immunostimulatory potency of this new candidate vaccine on human dendritic cells (DCs). L. plantarum displaying NY-ESO-1 induced NY-ESO-1 specific antibodies and T-cell responses in mice. By contrast, L. plantarum displaying conserved proteins such as heat shock protein-27 and galectin-1, did not induce immunity, suggesting that immune tolerance to self-proteins cannot be broken by oral administration of L. plantarum. With respect to immunomodulation, immature DCs incubated with wild type or L. plantarum-NY-ESO-1 upregulated the expression of co-stimulatory molecules and secreted a large amount of interleukin (IL)-12, TNF-α, but not IL-4. Moreover, they upregulated the expression of immunosuppressive factors such as IL-10 and indoleamine 2,3-dioxygenase. Although L. plantarum-matured DCs expressed inhibitory molecules, they stimulated allogeneic T cells in-vitro. Collectively, the data indicate that L. plantarum-NY-ESO-1 can evoke antigen-specific immunity upon oral administration and induce DC maturation, raising the potential of its use in cancer immunotherapies. PMID:26185907

Measurement of serum antibodies against NY-ESO-1 by ELISA: A guide for the treatment of specific immunotherapy for patients with advanced colorectal cancer.

Science.gov (United States)

Long, Yan-Yan; Wang, Yu; Huang, Qian-Rong; Zheng, Guang-Shun; Jiao, Shun-Chang

2014-10-01

NY-ESO-1 has been identified as one of the most immunogenic antigens; thus, is a highly attractive target for cancer immunotherapy. The present study analyzed the expression of serum antibodies (Abs) against NY-ESO-1 in patients with advanced colorectal cancer (CRC), with the aim of guiding the treatment of NY-ESO-1-based specific-immunotherapy for these patients. Furthermore, the present study was the first to evaluate the kinetic expression of anti-NY-ESO-1 Abs and investigate the possible influencing factors. A total of 239 serum samples from 155 pathologically confirmed patients with advanced CRC (stages III and IV) were collected. The presence of spontaneous Abs against NY-ESO-1 was analyzed using an enzyme-linked immunosorbent assay (ELISA). The results demonstrated that 24.5% (38/155) of the investigated patients were positive for NY-ESO-1-specific Abs. No statistically significant correlations were identified between the expression of anti-NY-ESO-1 Abs and clinicopathological parameters, including age and gender, location, grading, local infiltration, lymph node status, metastatic status and K-ras mutation status (P>0.05). In 59 patients, the kinetic expression of anti-NY-ESO-1 Abs was analyzed, of which 14 patients were initially positive and 45 patients were initially negative. Notably, 16/59 (27.1%) patients changed their expression status during the study period, and the initially positive patients were more likely to change compared with the initially negative patients (85.7 vs. 8.8%; Pguide the treatment of NY-ESO-1-based specific immunotherapy for patients with advanced CRC.

N° 15-2000: ESA, CERN and ESO launch "Physics on Stage"

Science.gov (United States)

2000-03-01

But how much do the citizens of Europe really know about physics? Here is a unique opportunity to learn more about this elusive subject! Beginning in February 2000, three major European research establishments [1] are organising a unique Europe-wide programme to raise the public awareness of physics and related sciences. "Physics on Stage" is launched by the European Space Agency (ESA), the European Laboratory for Particle Physics (CERN), and the European Southern Observatory (ESO), with support from the European Union (EU). Other partners include the European Physical Society (EPS) and the European Association for Astronomy Education (EAAE). This exciting programme is part of the European Week for Science and Technology and will culminate in a Science Festival during November 6-11, 2000, at CERN, Geneva. Why "Physics on Stage"? The primary goal of "Physics on Stage" is to counteract the current decline in interest and knowledge of physics among Europe's citizens by means of a series of highly visible promotional activities. It will bring together leading scientists and educators, government bodies and the media, to confront the diminishing attraction of physics to young people and to develop strategies to reverse this trend. The objective in the short term is to infuse excitement and to provide new educational materials. In the longer term, "Physics on Stage" will generate new developments by enabling experts throughout Europe to meet, exchange and innovate. "Physics on Stage" in 22 European Countries. "Physics on Stage" has been initiated in 22 European countries [2]. In each country, a dedicated National Steering Committee (NSC) is being formed which will be responsible for their own national programme. A list of contact addresses is attached below. "Physics on Stage" is based on a series of high-profile physics-related activities that will inform the European public in general, and European high school physics teachers and media representatives in particular

The Gaia-ESO Survey: the Galactic thick to thin disc transition

Science.gov (United States)

Recio-Blanco, A.; de Laverny, P.; Kordopatis, G.; Helmi, A.; Hill, V.; Gilmore, G.; Wyse, R.; Adibekyan, V.; Randich, S.; Asplund, M.; Feltzing, S.; Jeffries, R.; Micela, G.; Vallenari, A.; Alfaro, E.; Allende Prieto, C.; Bensby, T.; Bragaglia, A.; Flaccomio, E.; Koposov, S. E.; Korn, A.; Lanzafame, A.; Pancino, E.; Smiljanic, R.; Jackson, R.; Lewis, J.; Magrini, L.; Morbidelli, L.; Prisinzano, L.; Sacco, G.; Worley, C. C.; Hourihane, A.; Bergemann, M.; Costado, M. T.; Heiter, U.; Joffre, P.; Lardo, C.; Lind, K.; Maiorca, E.

2014-07-01

Aims: The nature of the thick disc and its relation to the thin disc is presently an important subject of debate. In fact, the structural and chemo-dynamical transition between disc populations can be used as a test of the proposed models of Galactic disc formation and evolution. Methods: We used the atmospheric parameters, [α/Fe] abundances, and radial velocities, which were determined from the Gaia-ESO Survey GIRAFFE spectra of FGK-type stars (first nine months of observations) to provide a chemo-kinematical characterisation of the disc stellar populations. We focussed on a subsample of 1016 stars with high-quality parameters, covering the volume | Z | contamination by thin disc stars suggests a gradient up to 64 ± 9 km s-1 dex-1. The distributions of azimuthal velocity, vertical velocity, and orbital parameters are also analysed for the chemically separated samples. Concerning the gradients with galactocentric radius, we find, for the thin disc, a flat behaviour of the azimuthal velocity, a metallicity gradient equal to -0.058 ± 0.008 dex kpc-1 and a very small positive [α/Fe] gradient. For the thick disc, flat gradients in [M/H] and [α/Fe] are derived. Conclusions: Our chemo-kinematical analysis suggests a picture where the thick disc seems to have experienced a settling process, during which its rotation increased progressively and, possibly, the azimuthal velocity dispersion decreased. At [M/H] ≈ -0.25 dex and [α/Fe]≈ 0.1 dex, the mean characteristics of the thick disc in vertical distance to the Galactic plane, rotation, rotational dispersion, and stellar orbits' eccentricity agree with that of the thin disc stars of the same metallicity, suggesting a possible connection between these two populations at a certain epoch of the disc evolution. Finally, the results presented here, based only on the first months of the Gaia ESO Survey observations, confirm how crucial large high-resolution spectroscopic surveys outside the solar neighbourhood are today

THE NARROW X-RAY TAIL AND DOUBLE Hα TAILS OF ESO 137-002 IN A3627

International Nuclear Information System (INIS)

Zhang, B.; Lin, X. B.; Kong, X.; Sun, M.; Ji, L.; Sarazin, C.; Nulsen, P. E. J.; Forman, W.; Jones, C.; Roediger, E.; Donahue, M.; Voit, G. M.

2013-01-01

We present the analysis of a deep Chandra observation of a ∼2 L * late-type galaxy, ESO 137-002, in the closest rich cluster A3627. The Chandra data reveal a long (∼>40 kpc) and narrow tail with a nearly constant width (∼3 kpc) to the southeast of the galaxy, and a leading edge ∼1.5 kpc from the galaxy center on the upstream side of the tail. The tail is most likely caused by the nearly edge-on stripping of ESO 137-002's interstellar medium (ISM) by ram pressure, compared to the nearly face-on stripping of ESO 137-001 discussed in our previous work. Spectral analysis of individual regions along the tail shows that the gas throughout it has a rather constant temperature, ∼1 keV, very close to the temperature of the tails of ESO 137-001, if the same atomic database is used. The derived gas abundance is low (∼0.2 solar with the single-kT model), an indication of the multiphase nature of the gas in the tail. The mass of the X-ray tail is only a small fraction (<5%) of the initial ISM mass of the galaxy, suggesting that the stripping is most likely at an early stage. However, with any of the single-kT, double-kT, and multi-kT models we tried, the tail is always 'over-pressured' relative to the surrounding intracluster medium (ICM), which could be due to the uncertainties in the abundance, thermal versus non-thermal X-ray emission, or magnetic support in the ICM. The Hα data from the Southern Observatory for Astrophysical Research show a ∼21 kpc tail spatially coincident with the X-ray tail, as well as a secondary tail (∼12 kpc long) to the east of the main tail diverging at an angle of ∼23° and starting at a distance of ∼7.5 kpc from the nucleus. At the position of the secondary Hα tail, the X-ray emission is also enhanced at the ∼2σ level. We compare the tails of ESO 137-001 and ESO 137-002, and also compare the tails to simulations. Both the similarities and differences of the tails pose challenges to the simulations. Several implications are

News from ESO Archive Services: Next Generation Request Handler and Data Access Delegation

Science.gov (United States)

Fourniol, N.; Lockhart, J.; Suchar, D.; Tacconi-Garman, L. E.; Moins, C.; Bierwirth, T.; Eglitis, P.; Vuong, M.; Micol, A.; Delmotte, N.; Vera, I.; Dobrzycki, A.; Forchì, V.; Lange, U.; Sogni, F.

2012-09-01

We present the new ESO Archive services which improve the electronic data access via the Download Manager and also provide PIs with the option to delegate data access to their collaborators via the Data Access Control.

Analysis of GAGE, NY-ESO-1 and SP17 cancer/testis antigen expression in early stage non-small cell lung carcinoma

International Nuclear Information System (INIS)

Gjerstorff, Morten F; Pøhl, Mette; Olsen, Karen E; Ditzel, Henrik J

2013-01-01

The unique expression pattern and immunogenic properties of cancer/testis antigens make them ideal targets for immunotherapy of cancer. The MAGE-A3 cancer/testis antigen is frequently expressed in non-small cell lung cancer (NSCLC) and vaccination with MAGE-A3 in patients with MAGE-A3-positive NSCLC has shown promising results. However, little is known about the expression of other cancer/testis antigens in NSCLC. In the present study the expression of cancer/testis antigens GAGE, NY-ESO-1 and SP17 was investigated in patients with completely resected, early stage, primary NSCLC. Tumor biopsies from normal lung tissue and from a large cohort (n = 169) of NSCLC patients were examined for GAGE, NY-ESO-1 and SP17 protein expression by immunohistochemical analysis. The expression of these antigens was further matched to clinical and pathological features using univariate cox regression analysis. GAGE and NY-ESO-1 cancer/testis antigens were not expressed in normal lung tissue, while SP17 was expressed in ciliated lung epithelia. The frequency of GAGE, NY-ESO-1 and SP17 expression in NSCLC tumors were 26.0% (44/169), 11.8% (20/169) and 4.7% (8/169), respectively, and 33.1% (56/169) of the tumors expressed at least one of these antigens. In general, the expression of GAGE, NY-ESO-1 and SP17 was not significantly associated with a specific histotype (adenocarcinoma vs. squamous cell carcinoma), but high-level GAGE expression (>50%) was more frequent in squamous cell carcinoma (p = 0.02). Furthermore, the frequency of GAGE expression was demonstrated to be significantly higher in stage II-IIIa than stage I NSCLC (17.0% vs. 35.8%; p = 0.02). Analysis of the relation between tumor expression of GAGE and NY-ESO-1 and survival endpoints revealed no significant associations. Our study demonstrates that GAGE, NY-ESO-1 and SP17 cancer/testis antigens are candidate targets for immunotherapy of NSCLC and further suggest that multi-antigen vaccines may be beneficial

PR-PR: cross-platform laboratory automation system.

Science.gov (United States)

Linshiz, Gregory; Stawski, Nina; Goyal, Garima; Bi, Changhao; Poust, Sean; Sharma, Monica; Mutalik, Vivek; Keasling, Jay D; Hillson, Nathan J

2014-08-15

To enable protocol standardization, sharing, and efficient implementation across laboratory automation platforms, we have further developed the PR-PR open-source high-level biology-friendly robot programming language as a cross-platform laboratory automation system. Beyond liquid-handling robotics, PR-PR now supports microfluidic and microscopy platforms, as well as protocol translation into human languages, such as English. While the same set of basic PR-PR commands and features are available for each supported platform, the underlying optimization and translation modules vary from platform to platform. Here, we describe these further developments to PR-PR, and demonstrate the experimental implementation and validation of PR-PR protocols for combinatorial modified Golden Gate DNA assembly across liquid-handling robotic, microfluidic, and manual platforms. To further test PR-PR cross-platform performance, we then implement and assess PR-PR protocols for Kunkel DNA mutagenesis and hierarchical Gibson DNA assembly for microfluidic and manual platforms.

The Gaia-ESO Survey: open clusters in Gaia-DR1 . A way forward to stellar age calibration

Science.gov (United States)

Randich, S.; Tognelli, E.; Jackson, R.; Jeffries, R. D.; Degl'Innocenti, S.; Pancino, E.; Re Fiorentin, P.; Spagna, A.; Sacco, G.; Bragaglia, A.; Magrini, L.; Prada Moroni, P. G.; Alfaro, E.; Franciosini, E.; Morbidelli, L.; Roccatagliata, V.; Bouy, H.; Bravi, L.; Jiménez-Esteban, F. M.; Jordi, C.; Zari, E.; Tautvaišiene, G.; Drazdauskas, A.; Mikolaitis, S.; Gilmore, G.; Feltzing, S.; Vallenari, A.; Bensby, T.; Koposov, S.; Korn, A.; Lanzafame, A.; Smiljanic, R.; Bayo, A.; Carraro, G.; Costado, M. T.; Heiter, U.; Hourihane, A.; Jofré, P.; Lewis, J.; Monaco, L.; Prisinzano, L.; Sbordone, L.; Sousa, S. G.; Worley, C. C.; Zaggia, S.

2018-05-01

Context. Determination and calibration of the ages of stars, which heavily rely on stellar evolutionary models, are very challenging, while representing a crucial aspect in many astrophysical areas. Aims: We describe the methodologies that, taking advantage of Gaia-DR1 and the Gaia-ESO Survey data, enable the comparison of observed open star cluster sequences with stellar evolutionary models. The final, long-term goal is the exploitation of open clusters as age calibrators. Methods: We perform a homogeneous analysis of eight open clusters using the Gaia-DR1 TGAS catalogue for bright members and information from the Gaia-ESO Survey for fainter stars. Cluster membership probabilities for the Gaia-ESO Survey targets are derived based on several spectroscopic tracers. The Gaia-ESO Survey also provides the cluster chemical composition. We obtain cluster parallaxes using two methods. The first one relies on the astrometric selection of a sample of bona fide members, while the other one fits the parallax distribution of a larger sample of TGAS sources. Ages and reddening values are recovered through a Bayesian analysis using the 2MASS magnitudes and three sets of standard models. Lithium depletion boundary (LDB) ages are also determined using literature observations and the same models employed for the Bayesian analysis. Results: For all but one cluster, parallaxes derived by us agree with those presented in Gaia Collaboration (2017, A&A, 601, A19), while a discrepancy is found for NGC 2516; we provide evidence supporting our own determination. Inferred cluster ages are robust against models and are generally consistent with literature values. Conclusions: The systematic parallax errors inherent in the Gaia DR1 data presently limit the precision of our results. Nevertheless, we have been able to place these eight clusters onto the same age scale for the first time, with good agreement between isochronal and LDB ages where there is overlap. Our approach appears promising

The big comet crash of 1994. Intensive observational campaign at ESO

Science.gov (United States)

1994-01-01

-based radio telescopes, as well as from several spacecraft, including Ulysses, now en route towards its first pass below the Sun. There may also be changes in the plasma torus that girdles Jupiter near the orbit of the volcanic moon Io, and some cometary dust particles may collect in Jupiter's faint ring. All in all, this spectacular event offers a unique opportunity to study Jupiter and its atmosphere. It may also provide a first ``look'' into its hitherto unobservable inner regions. Nobody knows for sure, how dramatic the effects of the impacts will actually be, but unless we are prepared to observe them, we may lose a great chance that is unlikely to come back in many years, if ever. WHICH PREPARATIONS HAVE BEEN MADE AT ESO ? In November of last year, a group of 25 cometary and planetary specialists from Europe and the U.S.A. met at ESO to discuss possible observations from the ESO La Silla observatory in connection with the cometary impacts at Jupiter. In a resulting report, they emphazised that ESO is in a particularly advantageous situation in this respect, because the excellent site of this observatory is located in the south and Jupiter will be 12 degrees south of the celestial equator at the time of the event and therefore well observable from here; the time available from observatories in the northern hemisphere will be much more restricted. Moreover, many different observing techniques are available at La Silla; this provides optimal conditions for effective coordination of the various programmes, in particular what concerns imaging and spectral observations in the infrared and submillimetre wavebands. A joint request for a coordinated observing programme was submitted by the group to the ESO Observing Programmes Committee. During its meeting at the end of November 1993, this committee reacted very positively and a substantial number of observing nights at the major telescopes at La Silla was granted at the time of the impacts in July 1994. The total amount of

Cambio climático en 4° de ESO

OpenAIRE

Rodriguez, Francisco

2007-01-01

La utilización de herramientas informáticas permite utilizar conceptos matemáticos sencillos para describir y estudiar problemas complejos. Este artículo es una propuesta para el aula de 4° de ESO (16 años) en la que se aplican algunos contenidos matemáticos de este curso al estudio, con rigor científico, de un problema real: la existencia de un cambio climático originado por las actividades humanas (calentamiento global antropogénico). Los contenidos matemáticos empleados son: lectura e inte...

ESO Advanced Data Products for the Virtual Observatory

Science.gov (United States)

Retzlaff, J.; Delmotte, N.; Rite, C.; Rosati, P.; Slijkhuis, R.; Vandame, B.

2006-07-01

Advanced Data Products, that is, completely reduced, fully characterized science-ready data sets, play a crucial role for the success of the Virtual Observatory as a whole. We report on on-going work at ESO towards the creation and publication of Advanced Data Products in compliance with present VO standards on resource metadata. The new deep NIR multi-color mosaic of the GOODS/CDF-S region is used to showcase different aspects of the entire process: data reduction employing our MVM-based reduction pipeline, calibration and data characterization procedures, standardization of metadata content, and, finally, a prospect of the scientific potential illustrated by new results on deep galaxy number counts.

Little Brother Joins the Large Family

Science.gov (United States)

2006-12-01

On the night of 15 December 2006, the fourth and last-to-be-installed VLTI Auxiliary Telescope (AT4) obtained its 'First Light'. The first images demonstrate that AT4 will be able to deliver the excellent image quality already delivered by the first three ATs. It will soon join its siblings to perform routinely interferometric measurements. ESO PR Photo 51a/06 ESO PR Photo 51a/06 VLT Auxiliary Telescope The VLT is composed of four 8.2-m Unit Telescope (Antu, Kueyen, Melipal and Yepun). They have been progressively put into service together with a vast suite of the most advanced astronomical instruments and are operated every night in the year. Contrary to other large astronomical telescopes, the VLT was designed from the beginning with the use of interferometry as a major goal. The VLT Interferometer (VLTI) combines starlight captured by two or three 8.2- VLT Unit Telescopes, dramatically increasing the spatial resolution and showing fine details of a large variety of celestial objects. ESO PR Photo 51b/06 ESO PR Photo 51b/06 One AT Under the Sky However, most of the time the large telescopes are used for other research purposes. They are therefore only available for interferometric observations during a limited number of nights every year. Thus, in order to exploit the VLTI each night and to achieve the full potential of this unique setup, some other (smaller), dedicated telescopes were included into the overall VLT concept. These telescopes, known as the VLTI Auxiliary Telescopes (ATs), are mounted on tracks and can be placed at precisely defined "parking" observing positions on the observatory platform. From these positions, their light beams are fed into the same common focal point via a complex system of reflecting mirrors mounted in an underground system of tunnels. The Auxiliary Telescopes are real technological jewels. They are placed in ultra-compact enclosures, complete with all necessary electronics, an air conditioning system and cooling liquid for

WISEA J114724.10-204021.3: A FREE-FLOATING PLANETARY MASS MEMBER OF THE TW HYA ASSOCIATION

Energy Technology Data Exchange (ETDEWEB)

Schneider, Adam C.; Windsor, James; Cushing, Michael C. [Department of Physics and Astronomy, University of Toledo, 2801 W. Bancroft Street, Toledo, OH 43606 (United States); Kirkpatrick, J. Davy [Infrared Processing and Analysis Center, California Institute of Technology, MS 100-22, Pasadena, CA 91125 (United States); Wright, Edward L., E-mail: Adam.Schneider@Utoledo.edu [Department of Physics and Astronomy, University of California, Los Angeles, 430 Portola Plaza, Box 951547, Los Angeles, CA 90095-1547 (United States)

2016-05-01

We present WISEA J114724.10-204021.3, a young, low-mass, high-probability member of the TW Hya association (TWA). WISEA J114724.10-204021.3 was discovered based on its red AllWISE color ( W 1 − W 2 = 0.63 mag) and extremely red 2MASS J − K {sub S} color (>2.64 mag), the latter of which is confirmed with near-infrared photometry from the Visible and Infrared Survey Telescope for Astronomy Hemisphere Survey ( J − K {sub S} = 2.57 ± 0.03). Follow-up near-infrared spectroscopy shows a spectral type of L7 ± 1 as well as several spectroscopic indicators of youth. These include a peaked H -band shape and a steeper K -band slope, traits typically attributed to low surface gravity. The sky position, proper motion, and distance estimates of WISEA J114724.10-204021.3 are all consistent with membership in the ∼10 Myr old TWA. Using the age of the TWA and evolutionary models, we estimate the mass of WISEA J114724.10-204021.3 to be 5–13 M {sub Jup}, making it one of the youngest and lowest-mass free-floating objects yet discovered in the Solar neighborhood.

A SIGNIFICANTLY LOW CO ABUNDANCE TOWARD THE TW Hya PROTOPLANETARY DISK: A PATH TO ACTIVE CARBON CHEMISTRY?

International Nuclear Information System (INIS)

Favre, Cécile; Cleeves, L. Ilsedore; Bergin, Edwin A.; Qi, Chunhua; Blake, Geoffrey A.

2013-01-01

In this Letter we report the CO abundance relative to H 2 derived toward the circumstellar disk of the T-Tauri star TW Hya from the HD (1 – 0) and C 18 O (2 – 1) emission lines. The HD (1 – 0) line was observed by the Herschel Space Observatory Photodetector Array Camera and Spectrometer whereas C 18 O (2 – 1) observations were carried out with the Submillimeter Array at a spatial resolution of 2.''8 × 1.''9 (corresponding to ∼151 × 103 AU). In the disk's warm molecular layer (T > 20 K) we measure a disk-averaged gas-phase CO abundance relative to H 2 of χ(CO) = (0.1-3) × 10 –5 , substantially lower than the canonical value of χ(CO) = 10 –4 . We infer that the best explanation of this low χ(CO) is the chemical destruction of CO followed by rapid formation of carbon chains, or perhaps CO 2 , that can subsequently freeze-out, resulting in the bulk mass of carbon locked up in ice grain mantles and oxygen in water. As a consequence of this likely time-dependent carbon sink mechanism, CO may be an unreliable tracer of H 2 gas mass

Acciones tutoriales a implantar para incidir en la relación entre práctica de botellón y resultados académicos en 3º de ESO

OpenAIRE

Berguilla Andión, Iker

2013-01-01

RESUMEN Se ha llevado a cabo una investigación acerca de la relación existente entre practicar botellón y el rendimiento académico en los alumnos de los dos grupos de 3º ESO de un I.E.S de Cantabria. Se trata de un estudio descriptivo de tipo cuantitativo con un tamaño de muestra de 52 alumnos para el que se ha empleado un cuestionario como instrumento de recogida de datos y que tiene como objetivo poder planificar de un modo más eficaz las actividades a desarrollar en la asignatura de tutorí...

The ESA/ESO/NASA Photoshop FITS Liberator 3: Have your say on new features

Science.gov (United States)

Nielsen, L. H.; Christensen, L. L.; Hurt, R. L.; Nielsen, K.; Johansen, T.

2008-06-01

The popular, free ESA/ESO/NASA Photoshop FITS Liberator image processing software (a plugin for Adobe Photoshop) is about to get simpler, faster and more user-friendly! Here we would like to solicit inputs from the community of users.

The Cosmic Christmas Ghost - Two Stunning Pictures of Young Stellar Clusters

Science.gov (United States)

2005-12-01

Just like Charles Dickens' Christmas Carol takes us on a journey into past, present and future in the time of only one Christmas Eve, two of ESO' s telescopes captured various stages in the life of a star in a single image. ESO PR Photo 42a/05 shows the area surrounding the stellar cluster NGC 2467, located in the southern constellation of Puppis (" The Stern" ). With an age of a few million years at most, it is a very active stellar nursery, where new stars are born continuously from large clouds of dust and gas. The image, looking like a colourful cosmic ghost or a gigantic celestial Mandrill [1] , contains the open clusters Haffner 18 (centre) and Haffner 19 (middle right: it is located inside the smaller pink region - the lower eye of the Mandrill), as well as vast areas of ionised gas. The bright star at the centre of the largest pink region on the bottom of the image is HD 64315, a massive young star that is helping shaping the structure of the whole nebular region. ESO PR Photo 42a/05 was taken with the Wide-Field Imager camera at the 2.2m MPG/ESO telescope located at La Silla, in Chile. Another image of the central part of this area is shown as ESO PR Photo 42b/05. It was obtained with the FORS2 instrument at ESO' s Very Large Telescope on Cerro Paranal, also in Chile. ESO PR Photo 42b/05 zooms in on the open stellar cluster Haffner 18, perfectly illustrating three different stages of this process of star formation: In the centre of the picture, Haffner 18, a group of mature stars that have already dispersed their birth nebulae, represents the completed product or immediate past of the star formation process. Located at the bottom left of this cluster, a very young star, just come into existence and, still surrounded by its birth cocoon of gas, provides insight into the very present of star birth. Finally, the dust clouds towards the right corner of the image are active stellar nurseries that will produce more new stars in the future. Haffner 18 contains

The line-of-sight warp of the spiral galaxy ESO 123-G23

NARCIS (Netherlands)

Gentile, G; Fraternali, F; Klein, U; Salucci, P

We present 3-D modelling of the distribution and kinematics of the neutral hydrogen in the spiral galaxy ESO 123- G23. The optical appearance of this galaxy is an almost perfectly edge-on disk, while the neutral hydrogen is found to extend vertically out to about 15 kpc on either side of the

Report on the ESO Workshop ''Satellites and Streams in Santiago''

Science.gov (United States)

Küpper, A. H. W.; Mieske, S.

2015-09-01

Galactic satellites and tidal streams are arguably the two most direct imprints of hierarchical structure formation in the haloes of galaxies. At this ESO workshop we sought to create the big picture of the galactic accretion process, and shed light on the interplay between satellites and streams in the Milky Way, Andromeda and beyond. The Scientific Organising Committee prepared a well-balanced programme with 60 talks and 30 poster contributions, resulting in a meeting which was greatly enjoyed by the more than 110 participants at the venue, and worldwide via Twitter (#SSS15).

First Kepler results on compact pulsators - II. KIC 010139564, a new pulsating subdwarf B (V361 Hya) star with an additional low-frequency mode

DEFF Research Database (Denmark)

Kawaler, Stephen; Reed, M.D.; Quint, A.C.

2010-01-01

We present the discovery of non-radial pulsations in a hot subdwarf B star based on 30.5 d of nearly continuous time series photometry using the Kepler spacecraft. KIC 010139564 is found to be a short-period pulsator of the V361 Hya (EC 14026) class with more than 10 independent pulsation modes...... whose periods range from 130 to 190 s. It also shows one periodicity at a period of 3165 s. If this periodicity is a high-order g-mode, then this star may be the hottest member of the hybrid DW Lyn stars. In addition to the resolved pulsation frequencies, additional periodic variations in the light...... are independent stellar oscillation modes. We find that most of the identified periodicities are indeed stable in phase and amplitude, suggesting a rotation period of 2-3 weeks for this star, but further observations are needed to confirm this suspicion....

Optical Detectors for Astronomy II : State-of-the-art at the Turn of the Millennium : 4th ESO CCD Workshop

CERN Document Server

Beletic, James

2000-01-01

th The 4 ESO CCO Workshop, Optical Detectors for Astronomy, was held during September 13-16, 1999 at its usual location, the headquarters of the European Southern Observatory in Garching, Germany. We prefer to remember this workshop as a "meeting of friends", who came to Garching to visit ESO and to present their work, rather than a formal meeting. Based on our experience with the 1996 ESO CCO workshop, we deliberately put emphasis on creating an environment that encouraged the participants to stay together and informally exchange ideas. These informal events began with a tour of the BWM auto factory and continued with a reception at "SchloB Beletic", the conference dinner at a real SchloB of the Bavarian International School (where the participants enjoyed basket, baseball, table soccer, rock climbing and eventually dancing) and concluded with a tour of the Paulaner Brewery and dinner at the Seehaus in the Englisher Garten. The lunch "Biergarten", adjacent to the poster session area, was a daily meeting poin...

And Then There Were Three...!

Science.gov (United States)

2000-01-01

VLT MELIPAL Achieves Successful "First Light" in Record Time This was a night to remember at the ESO Paranal Observatory! For the first time, three 8.2-m VLT telescopes were observing in parallel, with a combined mirror surface of nearly 160 m 2. In the evening of January 26, the third 8.2-m Unit Telescope, MELIPAL ("The Southern Cross" in the Mapuche language), was pointed to the sky for the first time and successfully achieved "First Light". During this night, a number of astronomical exposures were made that served to evaluate provisionally the performance of the new telescope. The ESO staff expressed great satisfaction with MELIPAL and there were broad smiles all over the mountain. The first images ESO PR Photo 04a/00 ESO PR Photo 04a/00 [Preview - JPEG: 400 x 352 pix - 95k] [Normal - JPEG: 800 x 688 pix - 110k] Caption : ESO PR Photo 04a/00 shows the "very first light" image for MELIPAL . It is that of a relatively bright star, as recorded by the Guide Probe at about 21:50 hrs local time on January 26, 2000. It is a 0.1 sec exposure, obtained after preliminary adjustment of the optics during a few iterations with the computer controlled "active optics" system. The image quality is measured as 0.46 arcsec FWHM (Full-Width at Half Maximum). ESO PR Photo 04b/00 ESO PR Photo 04b/00 [Preview - JPEG: 400 x 429 pix - 39k] [Normal - JPEG: 885 x 949 pix - 766k] Caption : ESO PR Photo 04b/00 shows the central region of the Crab Nebula, the famous supernova remnant in the constellation Taurus (The Bull). It was obtained early in the night of "First Light" with the third 8.2-m VLT Unit Telescope, MELIPAL . It is a composite of several 30-sec exposures with the VLT Test Camera in three broad-band filters, B (here rendered as blue; most synchrotron emission), V (green) and R (red; mostly emission from hydrogen atoms). The Crab Pulsar is visible to the left; it is the lower of the two brightest stars near each other. The image quality is about 0.9 arcsec, and is completely

MOSE: A Demonstrator for an Automatic Operational System for the Optical Turbulence Forecast for ESO Sites

Science.gov (United States)

Masciadri, Elena; Lascaux, F.; Turchi, A.; Fini, L.

2017-09-01

"Most of the observations performed with new-generation ground-based telescopes are employing the Service Mode. To optimize the flexible-scheduling of scientific programs and instruments, the optical turbulence (OT) forecast is a must, particularly when observations are supported by adaptive optics (AO) and Interferometry. Reliable OT forecast are crucial to optimize the usage of AO and interferometric facilities which is not possible when using only optical measurements. Numerical techniques are the best placed to achieve such a goal. The MOSE project (MOdeling ESO Sites), co-funded by ESO, aimed at proving the feasibility of the forecast of (1) all the classical atmospheric parameters (such as temperature, wind speed and direction, relative humidity) and (2) the optical turbulence i.e. the CN 2 profiles and all the main integrated astro-climatic parameters derived from the CN 2 (the seeing, the isoplanatic angle, the wavefront coherence time) above the two ESO sites of Cerro Paranal and Cerro Armazones. The proposed technique is based on the use of a non-hydrostatic atmospheric meso-scale model and a dedicated code for the optical turbulence. The final goal of the project aimed at implementing an automatic system for the operational forecasts of the aforementioned parameters to support the astronomical observations above the two sites. MOSE Phase A and B have been completed and a set of dedicated papers have been published on the topic. Model performances have been extensively quantified with several dedicated figures of merit and we proved that our tool is able to provide reliable forecasts of optical turbulence and atmospheric parameters with very satisfactory score of success. This should guarantee us to make a step ahead in the framework of the Service Mode of new generation telescopes. A conceptual design as well as an operational plan of the automatic system has been submitted to ESO as integral part of the feasibility study. We completed a negotiation with

Práticas de profissionais de Psicologia em situações de abuso sexual

Directory of Open Access Journals (Sweden)

Cátula da Luz Pelisoli

2015-01-01

Full Text Available El objetivo de este trabajo fue estudiar las experiencias y prácticas de profesionales de psicología en situaciones de abuso sexual infantil, ASI, en Brasil. Participaron 95 psicólogos (un 86,3% del sexo femenino de diferentes regiones del país, seleccionados a partir del procedimiento Snow Ball. Los participantes respondieron a un cuestionario, elaborado por el equipo de investigación profesional, en una encuesta en línea y biosociodemográfico. Los resultados indicaron que los psicólogos presentan formación predominantemente posgrado, se sienten calificados tanto para actuar en la evaluación cuanto en la atención clínica de esos casos, y se consideran familiarizados con el tema del abuso sexual. Sin embargo, algunos temas relacionados a la cuestión del abuso sexual aún son desconocidos de los psicólogos y nuevos instrumentos aún son poco utilizados. La mayoría de estos psicólogos ya envió documentos a la justicia y considera que sus documentos tuvieron gran importancia para el caso. Se discuten las repercusiones y posibles aplicaciones prácticas de estos resultados para el área.

"Diversidad de estilos de aprendizaje en el aula de música de ESO" [Diversity of learning styles in the music classrroom of ESO

Directory of Open Access Journals (Sweden)

Vicente Simón Simón

2011-01-01

Full Text Available RESUMEN:El presente artículo pretende mostrar los resultados de una investigación llevada a cabo en un centro de enseñanzas medias de Castilla-La Mancha, el IES Airén de Tomelloso (Ciudad Real. En él se trata de relacionar los estilos de aprendizaje del alumnado de 1º ciclo de ESO con sus aplicaciones e implicaciones en el campo académico de una materia determinada, la Música. El trabajo se sustenta en los datos obtenidos a través de dos cuestionarios, uno de reconocido prestigio (CHAEA y otro de creación propia (ESTMUS que pretenden determinar las relaciones existentes entre los aprendizajes musicales y los estilos de aprendizaje. Los resultados confirmaron la validez de nuestro cuestionario al reconocerle cerca de un 75 % de coincidencia entre las respuestas de los alumnos de nuestra muestra. Aunque no se observó un estilo de aprendizaje claramente predominante, destacan las personas en las que predomina el estilo de aprendizaje reflexivo en ambos casos.ABSTRACT:This article aims to show the results of research conducted in secondary schools of Castilla-La Mancha, IES Airen of Tomelloso (Ciudad Real. It seeks to relate the learning styles of students of 1 cycle of ESO with its applications and implications in the academic field of a specific subject Music. The work is based on data obtained through two questionnaires, a prestigious (CHAE and one own creation (ESTMUS seeking to determine the relationship between music learning and learning styles. The results confirmed the validity of our questionnaire to recognize about 75% overlap between the responses of students in our sample. Although not observed clearly predominant learning style, outstanding people in the predominantly reflexive learning style in both cases.

Nuclei of dwarf spheroidal galaxies KKs 3 and ESO 269-66 and their counterparts in our Galaxy

Science.gov (United States)

Sharina, M. E.; Shimansky, V. V.; Kniazev, A. Y.

2017-10-01

We present the analysis of medium-resolution spectra obtained at the Southern African Large Telescope for nuclear globular clusters (GCs) in two dwarf spheroidal galaxies (dSphs). The galaxies have similar star formation histories, but they are situated in completely different environments. ESO 269-66 is a close neighbour of the giant S0 NGC 5128. KKs 3 is one of the few truly isolated dSphs within 10 Mpc. We estimate the helium abundance Y = 0.3, age = 12.6 ± 1 Gyr, [Fe/H] = -1.5, -1.55 ± 0.2 dex, and abundances of C, N, Mg, Ca, Ti, and Cr for the nuclei of ESO 269-66 and KKs 3. Our surface photometry results using Hubble Space Telescope images yield the half-light radius of the cluster in KKs 3, rh = 4.8 ± 0.2 pc. We demonstrate the similarities of medium-resolution spectra, ages, chemical compositions, and structure for GCs in ESO 269-66 and KKs 3 and for several massive Galactic GCs with [Fe/H] ∼ -1.6 dex. All Galactic GCs posses Extended Blue Horizontal Branches and multiple stellar populations. Five of the selected Galactic objects are iron-complex GCs. Our results indicate that the sample GCs observed now in different environments had similar conditions of their formation ∼1 Gyr after the Big Bang.

ESO 113-IG45 galaxy and/or quasar?

CERN Document Server

West, R M; Danks, A C

1978-01-01

Spectroscopy, UBV photometry and photography have been obtained of the extraordinary 13th magnitude object ESO 113-IG45 identified as a Seyfert galaxy by Fairall (1977); R.A.=01/sup h/ 21/sup m/.9; Decl .=-59 degrees 04' (1950). V/sub 0/=13630+or-50 km s/sup -1/; M/sub V /=-24/sup m/.0; largest diameter 75 kpc or more (with H/sub 0/=55 km s /sup -1/ Mpc/sup -1/). The nucleus is stellar-like and several times more luminous than the surrounding envelope which has a well-developed lane-structure. It is the intrinsically most luminous Seyfert nuclear yet known, and may be described as a 'quasar in the center of a (spiral) galaxy'. It is probably associated with the X-ray source 2A0120-591. (14 refs).

First Images and Spectra from ISAAC on UT1

Science.gov (United States)

1998-11-01

New VLT Instrument Delivers Spectacular Infrared Views of the Southern Sky The VLT Infrared Spectrometer And Array Camera (ISAAC) [1] was installed at the first 8.2-m VLT Unit Telescope (UT1) on November 14, 1998, cf. ESO PR Photos 42a-h/98. ISAAC is the second major VLT instrument to be installed at the VLT and the first to be fully designed and developed at ESO within its Instrumentation Division. Following evacuation of its large vacuum vessel, cooling to cryogenic temperature and alignment with the telescope according to the planned schedule, it successfully achieved technical first light during the night between November 16 and 17, 1998. ESO PR Photo 46a/98 ESO PR Photo 46a/98 [JPEG: 800 x 847 pix - 432k] [High-Res - JPEG: 3000 x 3175 pix - 2.9Mb] PR Photo 46a/98 shows ISAAC as it is now mounted at the UT1 Nasmyth B adaptor-rotator (right; blue colour). The co-rotator system (left) through which the various cables are fed to the instrument, is also well visible. (Photo obtained on November 16, 1998). The first focus tests on stars yielded images of excellent sharpness, around 0.45 arcsec full-width-half-maximum (FWHM). During the following nights, even better images, as small as 0.25 arcsec in relatively short exposures, were obtained, testifying to the quality of the site as well as the optical quality of both the telescope and instrument. Observations were executed using the new VLT Control and Data Flow Systems which are driven by Observation Blocks that define all details of the required astronomical exposures. In addition to direct images in various infrared colours (selected with different optical filters), spectroscopic observations were also made during the first few nights of operation. This Press Release is accompanied by several images and spectra which illustrate some of the exceptional new astronomical capabilities offered by this instrument. Star-Forming Region RCW38 in the Milky Way ESO PR Photo 46b/98 ESO PR Photo 46b/98 [Preview - JPEG: 800 x

Una experiencia de indagación cooperativa para aprender ciencias en educación secundaria participando en las prácticas científicas

Directory of Open Access Journals (Sweden)

Beatriz Crujeiras-Pérez

2018-01-01

Full Text Available En este trabajo se describe una experiencia de indagación cooperativa encaminada a promover la participación del alumnado de secundaria en las prácticas científicas y se analizan los desempeños del alumnado relativos a la práctica de indagación. La actividad consiste en averiguar cuál sería la mejor pelota saltarina para ganar un concurso y se lleva a cabo en un aula de 4º de ESO durante tres sesiones de 50 minutos encaminadas a la preparación de la experiencia, su realización y la comunicación de los resultados. Para el análisis se examinan las producciones escritas de los estudiantes utilizando una rúbrica. Los resultados principales muestran bajos niveles de desempeño en los grupos, especialmente aquéllos relacionados con la planificación de la investigación y el establecimiento de conclusiones.

VLTI First Fringes with Two Auxiliary Telescopes at Paranal

Science.gov (United States)

2005-03-01

World's Largest Interferometer with Moving Optical Telescopes on Track Summary The Very Large Telescope Interferometer (VLTI) at Paranal Observatory has just seen another extension of its already impressive capabilities by combining interferometrically the light from two relocatable 1.8-m Auxiliary Telescopes. Following the installation of the first Auxiliary Telescope (AT) in January 2004 (see ESO PR 01/04), the second AT arrived at the VLT platform by the end of 2004. Shortly thereafter, during the night of February 2 to 3, 2005, the two high-tech telescopes teamed up and quickly succeeded in performing interferometric observations. This achievement heralds an era of new scientific discoveries. Both Auxiliary Telescopes will be offered from October 1, 2005 to the community of astronomers for routine observations, together with the MIDI instrument. By the end of 2006, Paranal will be home to four operational ATs that may be placed at 30 different positions and thus be combined in a very large number of ways ("baselines"). This will enable the VLTI to operate with enormous flexibility and, in particular, to obtain extremely detailed (sharp) images of celestial objects - ultimately with a resolution that corresponds to detecting an astronaut on the Moon. PR Photo 07a/05: Paranal Observing Platform with AT1 and AT2 PR Photo 07b/05: AT1 and AT2 with Open Domes PR Photo 07c/05: Evening at Paranal with AT1 and AT2 PR Photo 07d/05: AT1 and AT2 under the Southern Sky PR Photo 07e/05: First Fringes with AT1 and AT2 PR Video Clip 01/05: Two ATs at Paranal (Extract from ESO Newsreel 15) A Most Advanced Device ESO PR Video 01/05 ESO PR Video 01/05 Two Auxiliary Telescopes at Paranal [QuickTime: 160 x 120 pix - 37Mb - 4:30 min] [QuickTime: 320 x 240 pix - 64Mb - 4:30 min] ESO PR Photo 07a/05 ESO PR Photo 07a/05 [Preview - JPEG: 493 x400 pix - 44k] [Normal - JPEG: 985 x 800 pix - 727k] [HiRes - JPEG: 5000 x 4060 pix - 13.8M] Captions: ESO PR Video Clip 01/05 is an extract from

The OmegaCAM 16K x 16K CCD detector system for the ESO VLT Survey Telescope (VST)

Science.gov (United States)

Iwert, Olaf; Baade, D.; Balestra, A.; Baruffolo, A.; Bortolussi, A.; Christen, F.; Cumani, C.; Deiries, S.; Downing, M.; Geimer, C.; Hess, G.; Hess, J.; Kuijken, K.; Lizon, J.; Muschielok, B.; Nicklas, H.; Reiss, R.; Reyes, J.; Silber, A.; Thillerup, J.; Valentijn, E.

2006-06-01

A 16K x 16K, 1 degree x 1 degree field, detector system was developed by ESO for the OmegaCAM instrument for use on the purpose built ESO VLT Survey Telescope (VST). The focal plane consists of an 8 x 4 mosaic of 2K x 4K 15um pixel e2v CCDs and four 2K x 4K CCDs on the periphery for the opto-mechanical control of the telescope. The VST is a single instrument telescope. This placed stringent reliability requirements on the OmegaCAM detector system such as 10 years lifetime and maximum downtime of 1.5 %. Mounting at Cassegrain focus required a highly autonomous self-contained cooling system that could deliver 65 W of cooling power. Interface space for the detector head was severely limited by the way the instrument encloses the CCD cryostat. The detector system features several novel ideas tailored to meet these requirements and described in this paper: Key design drivers of the detector head were the easily separable but precisely aligned connections to the optical field flattener on the top and the cooling system at the bottom. Material selection, surface treatment, specialized coatings and in-situ plasma cleaning were crucial to prevent contamination of the detectors. Inside the cryostat, cryogenic and electrical connections were disentangled to keep the configuration modular, integration friendly and the detectors in a safe condition during all mounting steps. A compact unit for logging up to 125 Pt100 temperature sensors and associated thermal control loops was developed (ESO's new housekeeping unit PULPO 2), together with several new modular Pt100 packaging and mounting concepts. The electrical grouping of CCDs based on process parameters and test results is explained. Three ESO standardized FIERA CCD controllers in different configurations are used. Their synchronization mechanism for read-out is discussed in connection with the CCD grouping scheme, the shutter, and the integrated guiding and image analysis facility with four independent 2K x 4K CCDs. An

X-shooter, the new wide band intermediate resolution spectrograph at the ESO Very Large Telescope

DEFF Research Database (Denmark)

Vernet, J.; Dekker, H.; D'Odorico, S.

2011-01-01

X-shooter is the first 2nd generation instrument of the ESO Very Large Telescope (VLT). It is a very efficient, single-target, intermediate-resolution spectrograph that was installed at the Cassegrain focus of UT2 in 2009. The instrument covers, in a single exposure, the spectral range from 300 t...

X-shooter, the new wide band intermediate resolution spectrograph at the ESO Very Large Telescope

NARCIS (Netherlands)

Vernet, J.; Dekker, H.; D'Odorico, S.; Kaper, L.; Kjaergaard, P.; Hammer, F.; Randich, S.; Zerbi, F.; Groot, P.J.; Hjorth, J.; Guinouard, I.; Navarro, R.; Adolfse, T.; Albers, P.W.; Amans, J.-P.; Andersen, J.J.; Andersen, M.I.; Binetruy, P.; Bristow, P.; Castillo, R.; Chemla, F.; Christensen, L.; Conconi, P.; Conzelmann, R.; Dam, J.; De Caprio, V.; de Ugarte Postigo, A.; Delabre, B.; Di Marcantonio, P.; Downing, M.; Elswijk, E.; Finger, G.; Fischer, G.; Flores, H.; François, P.; Goldoni, P.; Guglielmi, L.; Haigron, R.; Hanenburg, H.; Hendriks, I.; Horrobin, M.; Horville, D.; Jessen, N.C.; Kerber, F.; Kern, L.; Kiekebusch, M.; Kleszcz, P.; Klougart, J.; Kragt, J.; Larsen, H.H.; Lizon, J.-L.; Lucuix, C.; Mainieri, V.; Manuputy, R.; Martayan, C.; Mason, E.; Mazzoleni, R.; Michaelsen, N.; Modigliani, A.; Moehler, S.; Møller, P.; Norup Sørensen, A.; Nørregaard, P.; Péroux, C.; Patat, F.; Pena, E.; Pragt, J.; Reinero, C.; Rigal, F.; Riva, M.; Roelfsema, R.; Royer, F.; Sacco, G.; Santin, P.; Schoenmaker, T.; Spano, P.; Sweers, E.; ter Horst, R.; Tintori, M.; Tromp, N.; van Dael, P.; van Vliet, H.; Venema, L.; Vidali, M.; Vinther, J.; Vola, P.; Winters, R.; Wistisen, D.; Wulterkens, G.; Zacchei, A.

2011-01-01

X-shooter is the first 2nd generation instrument of the ESO Very Large Telescope (VLT). It is a very efficient, single-target, intermediate-resolution spectrograph that was installed at the Cassegrain focus of UT2 in 2009. The instrument covers, in a single exposure, the spectral range from 300 to

The Atacama Large Millimeter Array (ALMA)

Science.gov (United States)

1999-06-01

The Atacama Large Millimeter Array (ALMA) is the new name [2] for a giant millimeter-wavelength telescope project. As described in the accompanying joint press release by ESO and the U.S. National Science Foundation , the present design and development phase is now a Europe-U.S. collaboration, and may soon include Japan. ALMA may become the largest ground-based astronomy project of the next decade after VLT/VLTI, and one of the major new facilities for world astronomy. ALMA will make it possible to study the origins of galaxies, stars and planets. As presently envisaged, ALMA will be comprised of up to 64 12-meter diameter antennas distributed over an area 10 km across. ESO PR Photo 24a/99 shows an artist's concept of a portion of the array in a compact configuration. ESO PR Video Clip 03/99 illustrates how all the antennas will move in unison to point to a single astronomical object and follow it as it traverses the sky. In this way the combined telescope will produce astronomical images of great sharpness and sensitivity [3]. An exceptional site For such observations to be possible the atmosphere above the telescope must be transparent at millimeter and submillimeter wavelengths. This requires a site that is high and dry, and a high plateau in the Atacama desert of Chile, probably the world's driest, is ideal - the next best thing to outer space for these observations. ESO PR Photo 24b/99 shows the location of the chosen site at Chajnantor, at 5000 meters altitude and 60 kilometers east of the village of San Pedro de Atacama, as seen from the Space Shuttle during a servicing mission of the Hubble Space Telescope. ESO PR Photo 24c/99 and ESO PR Photo 24d/99 show a satellite image of the immediate vicinity and the site marked on a map of northern Chile. ALMA will be the highest continuously operated observatory in the world. The stark nature of this extreme site is well illustrated by the panoramic view in ESO PR Photo 24e/99. High sensitivity and sharp images ALMA

Dos prólogos para un mismo informe: El Nunca Más y la memoria de las desapariciones

Directory of Open Access Journals (Sweden)

Emilio Crenzel

2007-12-01

Full Text Available En este artículo se analizarán dos prólogos al informe Nunca Más, elaborado por la Comisión Nacional sobre la Desaparición de Personas en 1984. El primero, escrito por la Comisión, expuso la interpretación del gobierno de Alfonsín sobre el pasado de violencia política y horror y postuló una nueva lectura sobre la identidad de los desaparecidos y el papel de la sociedad argentina en esos hechos. El segundo, elaborado por la Secretaría de Derechos Humanos de la Nación fue añadido en 2006. Su comparación ilustrará los cambios y continuidades en la memoria del pasado reciente en el país.

Extinction in the Galaxy from surface brightnesses of ESO-LV galaxies : Testing "standard" extinction maps

NARCIS (Netherlands)

Choloniewski, J.; Valentijn, E. A.

A new method for the determination of the extinction in the Galaxy is proposed. The method uses surface brightnesses of external galaxies in the B and R-bands. The observational data have been taken from the ESO-LV galaxy catalog. As a first application of our model we derive the ratio of R-band to

The Gaia-ESO Survey: the present-day radial metallicity distribution of the Galactic disc probed by pre-main-sequence clusters

Science.gov (United States)

Spina, L.; Randich, S.; Magrini, L.; Jeffries, R. D.; Friel, E. D.; Sacco, G. G.; Pancino, E.; Bonito, R.; Bravi, L.; Franciosini, E.; Klutsch, A.; Montes, D.; Gilmore, G.; Vallenari, A.; Bensby, T.; Bragaglia, A.; Flaccomio, E.; Koposov, S. E.; Korn, A. J.; Lanzafame, A. C.; Smiljanic, R.; Bayo, A.; Carraro, G.; Casey, A. R.; Costado, M. T.; Damiani, F.; Donati, P.; Frasca, A.; Hourihane, A.; Jofré, P.; Lewis, J.; Lind, K.; Monaco, L.; Morbidelli, L.; Prisinzano, L.; Sousa, S. G.; Worley, C. C.; Zaggia, S.

2017-05-01

Context. The radial metallicity distribution in the Galactic thin disc represents a crucial constraint for modelling disc formation and evolution. Open star clusters allow us to derive both the radial metallicity distribution and its evolution over time. Aims: In this paper we perform the first investigation of the present-day radial metallicity distribution based on [Fe/H] determinations in late type members of pre-main-sequence clusters. Because of their youth, these clusters are therefore essential for tracing the current interstellar medium metallicity. Methods: We used the products of the Gaia-ESO Survey analysis of 12 young regions (age ages is not easily explained by the models. Our results reveal a complex interplay of several processes (e.g. star formation activity, initial mass function, supernova yields, gas flows) that controlled the recent evolution of the Milky Way. Based on observations made with the ESO/VLT, at Paranal Observatory, under program 188.B-3002 (The Gaia-ESO Public Spectroscopic Survey).Full Table 1 is only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/601/A70

Young Astronomers' Observe with ESO Telescopes

Science.gov (United States)

1995-11-01

Today, forty 16-18 year old students and their teachers are concluding a one-week, educational `working visit' to the ESO Headquarters in Garching (See ESO Press Release 14/95 of 8 November 1995). They are the winners of the Europe-wide contest `Europe Towards the Stars', organised by ESO with the support of the European Union, under the auspices of the Third European Week for Scientific and Technological Culture. From November 14-20, they have worked with professional ESO astronomers in order to get insight into the methods and principles of modern astronomy and astrophysics, as carried out at one of the world's foremost international centres. This included very successful remote observations with the ESO 3.5-m New Technology Telescope (NTT) and the 1.4-m Coude Auxiliary Telescope (CAT) via a satellite link between the ESO Headquarters and the La Silla observatory in Chile, 12,000 kilometres away. After a general introduction to modern astronomy on the first day of the visit, the participants divided into six teams, according to their interests. Some chose to observe distant galaxies, others prefered to have a closer look on binary stars, and one team decided to investigate a star which is thought to be surrounded by a proto-planetary system. Each team was supported by an experienced ESO astronomer. Then followed the observations at the remote consoles during three nights, the first at the NTT and the following at the CAT. Each team had access to the telescope during half a night. Although the work schedule - exactly as in `real' science - was quite hard, especially during the following data reduction and interpretative phase, all teams managed extremely well and in high spirits. The young astronomers' observations were favoured by excellent atmospheric conditions. At the NTT, the seeing was better than 0.5 arcsecond during several hours, an exceptional value that allows very good images to be obtained. All observations represent solid and interesting science, and

Desigualdad de género en las relaciones conyugales y prácticas sexuales de los hombres mexicanos

Directory of Open Access Journals (Sweden)

Ivonne Szasz

2008-01-01

Full Text Available El objetivo de este trabajo es explorar, con base en los resultados de la Encuesta de Salud Reproductiva con Población Derechohabiente del Instituto Mexicano del Seguro Social (imssIMSS de 1998, las hipótesis que se desprenden de los estudios cualitativos. Esos estudios exploratorios sugieren importantes conexiones entre la construcción de las identidades masculinas y las prácticas anticonceptivas, de relacionamiento sexual y de prevención de las infecciones de transmisión sexual. También advierten de la existencia de marcadas diferencias generacionales y por clase social en las desigualdades de género que se expresan en las relaciones conyugales.Tomando en cuenta lo anterior, buscamos poner a prueba la hipótesis de que cuando las relaciones de género son más autoritarias en la pareja, los hombres están más expuestos a ejercer prácticas sexuales que pueden representar riesgo para la salud de ellos o sus parejas. Para ello ajustamos tres modelos de regresión logística teniendo como variables dependientes algunas que indican prácticas sexuales que pueden implicar riesgos, y revisamos si se mantiene la relación esperada al incluir la influencia conjunta de las variables indicativas de la supremacía masculina en las relaciones conyugales, así como el estrato socioeconómico y edad de los hombres estudiados.

Fourth Light at Paranal!

Science.gov (United States)

2000-09-01

mirror system. At 21:44 hrs (01:44 UT), the Test Camera at the Cassegrain focus within the M1 mirror cell was opened for 30 seconds, with the planetary nebula Hen 2-428 in the field. The resulting "First Light" image was immediately read out and appeared on the computer screen at 21:45:53 hrs (01:45:53 UT). "Not bad! - "Very nice!" were the first, "business-as-usual"-like comments in the room. The zenith distance during this observation was 44° and the image quality was measured as 0.9 arcsec, exactly the same as that registered by the Seeing Monitoring Telescope outside the telescope building. There was some wind. ESO PR Photo 22a/00 ESO PR Photo 22a/00 [Preview - JPEG: 374 x 400 pix - 128k] [Normal - JPEG: 978 x 1046 pix - 728k] Caption : ESO PR Photo 22a/00 shows a colour composite of some of the first astronomical exposures obtained by YEPUN . The object is the planetary nebula Hen 2-428 that is located at a distance of 6,000-8,000 light-years and seen in a dense sky field, only 2° from the main plane of the Milky Way. As other planetary nebulae, it is caused by a dying star (the bluish object at the centre) that shreds its outer layers. The image is based on exposures through three optical filtres: B(lue) (10 min exposure, seeing 0.9 arcsec; here rendered as blue), V(isual) (5 min; 0.9 arcsec; green) and R(ed) (3 min; 0.9 arcsec; red). The field measures 88 x 78 arcsec 2 (1 pixel = 0.09 arcsec). North is to the lower right and East is to the lower left. The 5-day old Moon was about 90° away in the sky that was accordingly bright. The zenith angle was 44°. The ESO staff then proceeded to take a series of three photos with longer exposures through three different optical filtres. They have been combined to produce the image shown in ESO PR Photo 22a/00 . More astronomical images were obtained in sequence, first of the dwarf galaxy NGC 6822 in the Local Group (see PR Photo 22f/00 below) and then of the spiral galaxy NGC 7793 . All 8.2-m telescopes now in operation

MAGE-A1, GAGE and NY-ESO-1 cancer/testis antigen expression during human gonadal development

DEFF Research Database (Denmark)

Gjerstorff, Morten F; Kock, Kirsten; Nielsen, Ole

2007-01-01

BACKGROUND: Cancer/testis antigens (CTAs) are expressed in several cancers and during normal adult male germ cell differentiation. Little is known about their role in fetal development of human germ cells. METHODS: We examined expression of the CTAs MAGE-A1, GAGE and NY-ESO-1 in fetal gonads...

Utilización de videojuegos como elemento motivador y de mejora del rendimiento académico en 1º de ESO

OpenAIRE

Andrio-Balado, Vicent

2013-01-01

En este trabajo se estudia las opiniones de los docentes y los alumnos de 1º de ESO de Escuelas Pías de Castelló sobre las el uso de las TIC y de videojuegos como herramientas didácticas. Después, se calculan los costes de un aula TIC y el de sustituir los libros de texto en papel por libros digitales. Además, se propone una serie de videojuegos para explicar, reforzar o profundizar en todas las unidades didácticas de la asignatura de matemáticas de 1º de ESO de este centro.

PrP Knockout Cells Expressing Transmembrane PrP Resist Prion Infection.

Science.gov (United States)

Marshall, Karen E; Hughson, Andrew; Vascellari, Sarah; Priola, Suzette A; Sakudo, Akikazu; Onodera, Takashi; Baron, Gerald S

2017-01-15

Glycosylphosphatidylinositol (GPI) anchoring of the prion protein (PrP C ) influences PrP C misfolding into the disease-associated isoform, PrP res , as well as prion propagation and infectivity. GPI proteins are found in cholesterol- and sphingolipid-rich membrane regions called rafts. Exchanging the GPI anchor for a nonraft transmembrane sequence redirects PrP C away from rafts. Previous studies showed that nonraft transmembrane PrP C variants resist conversion to PrP res when transfected into scrapie-infected N2a neuroblastoma cells, likely due to segregation of transmembrane PrP C and GPI-anchored PrP res in distinct membrane environments. Thus, it remained unclear whether transmembrane PrP C might convert to PrP res if seeded by an exogenous source of PrP res not associated with host cell rafts and without the potential influence of endogenous expression of GPI-anchored PrP C To further explore these questions, constructs containing either a C-terminal wild-type GPI anchor signal sequence or a nonraft transmembrane sequence containing a flexible linker were expressed in a cell line derived from PrP knockout hippocampal neurons, NpL2. NpL2 cells have physiological similarities to primary neurons, representing a novel and advantageous model for studying transmissible spongiform encephalopathy (TSE) infection. Cells were infected with inocula from multiple prion strains and in different biochemical states (i.e., membrane bound as in brain microsomes from wild-type mice or purified GPI-anchorless amyloid fibrils). Only GPI-anchored PrP C supported persistent PrP res propagation. Our data provide strong evidence that in cell culture GPI anchor-directed membrane association of PrP C is required for persistent PrP res propagation, implicating raft microdomains as a location for conversion. Mechanisms of prion propagation, and what makes them transmissible, are poorly understood. Glycosylphosphatidylinositol (GPI) membrane anchoring of the prion protein (PrP C

Peruanos en Córdoba: migraciones, talleres textiles y prácticas comunitarias

Directory of Open Access Journals (Sweden)

María José Magliano

2017-04-01

Full Text Available A partir de los resultados de un trabajo de campo etnográfico, este artículo se propone indagar en las trayectorias laborales en talleres textiles “informales” de migrantes peruanos que viven en territorios de relegación urbana de Córdoba (Argentina, en el marco de las estrategias de acceso a la ciudad y de reproducción familiar. Asimismo, reflexiona sobre las prácticas comunitarias, en tanto recursos de organización barrial tendientes a la autogestión, que se despliegan en esos territorios en relación con el desarrollo de los talleres textiles. Este estudio muestra cómo ciertos procesos que exceden la migración en sí misma –como la presencia/ausencia del Estado, las redes de trabajo informal y la dificultad para el acceso a la vivienda– se relacionan con las movilidades e inserciones laborales de la población migrante de forma tal que posibilitan y estimulan la existencia y proliferación de talleres textiles informales en zonas concretas de la ciudad.

Astrometric positions of minor planets in September 1983; four discoveries; ESO, La Silla, Chile

International Nuclear Information System (INIS)

Debehogne, H.; Mourao, R.R.

1985-01-01

84 astronomical positions of asteroids, 420 stars residuals and dependences are given as obtained from photographic observations made at the GPO, Grand Prisme Objectif (D = 40 cm, f = 4 m) - ESO, La Silla, Chile, during September 1983. The reductions of the observations were obtained by means of five reference stars (SAO Catalogue) using two methods: dependences (to have...the dependences) and least squares (for stellar residuals). 2 tabs. (author)

NY-ESO-1- and survivin-specific T-cell responses in the peripheral blood from patients with glioma

DEFF Research Database (Denmark)

Liu, Zhenjiang; Poiret, Thomas; Persson, Oscar

2018-01-01

The prognosis for patients with glioblastoma is grim. Ex vivo expanded tumor-associated antigen (TAA)-reactive T-cells from patients with glioma may represent a viable source for anticancer-directed cellular therapies. Immunohistochemistry was used to test the survivin (n = 40 samples) and NY-ESO...

Highlights from the CERN/ESO/NordForsk ''Gender in Physics Day''

Science.gov (United States)

Primas, F.; Guinot, G.; Strandberg, L.

2017-03-01

In their role as observers on the EU Gender Equality Network in the European Research Area (GENERA) project, funded under the Horizon 2020 framework, CERN, ESO and NordForsk joined forces and organised a Gender in Physics Day at the CERN Globe of Science and Innovation. The one-day conference aimed to examine innovative activities promoting gender equality, and to discuss gender-oriented policies and best practice in the European Research Area (with special emphasis on intergovernmental organisations), as well as the importance of building solid networks. The event was very well attended and was declared a success. The main highlights of the meeting are reported.

STRESS a SN survey at ESO

Science.gov (United States)

Botticella, M. T.

We performed the Southern inTermediate Redshift ESO Supernova Search (STRESS), a survey specifically designed to measure the rate of both SNe Ia and CC SNe, in order to obtain a direct comparison of the high redshift and local rates and to investigate the dependence of the rates on specific galaxy properties, most notably their colour. We found that the type Ia SN rate, at mean redshift z = 0.3, is 0.22+0.10+0.16-0.08-0.14 h270 SNu, while the CC SN rate, at z = 0.21, is 0.82+0.31+0.300.24-0.26 h270 SNu. The quoted errors are the statistical and systematic uncertainties. With respect to the local value, the CC SN rate at z = 0.2 is higher by a factor of ˜ 2, whereas the type Ia SN rate remains almost constant. We also measured the SN rates in the red and blue galaxies and found that the SN Ia rate seems to be constant in galaxies of different colour, whereas the CC SN rate seems to peak in blue galaxies, as in the local Universe. Finally we exploited the link between SFH and SN rates to predict the evolutionary behaviour of the SN rates and compare it with the path indicated by observations.

Live Webcasts from CERN and ESO for European Science and Technology Week

Science.gov (United States)

2002-10-01

Visit http://www.cern.ch/sci-tech on 7 - 8 November to find out what modern Europeans can't live without. Seven of Europe's leading Research Organizations [1] are presenting three live Webcasts from CERN in a joint outreach programme for the European Science and Technology Week . The aim of Sci-Tech... couldn't be without it! is to show how today's society couldn't be without cutting-edge scientific research. See also ESO Press Release 05/02. Northern Europeans can't imagine their households without ovens, whereas Southern Europeans identify the refrigerator as the most essential household appliance. In the area of communications, cars and motorbikes are clearly the technologies of choice in Italy, but are regarded as less important in countries like Norway and Germany. For entertainment, the personal computer is a clear winner as the device is considered most essential by all Europeans, followed by the TV and the Internet. This hit parade of technological marvels is the result of a phone and online survey conducted by the Sci-Tech... couldn't be without it! team for this year's European Science and Technology Week on 4-10 November. The technologies Europeans could not be without, form the starting point of three entertaining and informative Webcast shows in Italian (Thursday 7 November at 10:00 CET), French (Thursday 7 November at 15:00 CET) and English (Friday 8 November at 15:00 CET), broadcast live on the Internet from a studio at CERN. During these Webcasts scientists from the seven research Organizations and their industrial partners Sun Microsystems, Siemens, L'Oreal and Luminex will engage - from the CERN studio or from remote locations through teleconference links - an audience of Internauts all over the world. The public will be taken inside their most popular gadgets to discover the science that made them possible and how vital fundamental research has been in the creation of modern technology. Fundamental science will be brought as close as possible to

Sharpest Ever VLT Images at NAOS-CONICA "First Light"

Science.gov (United States)

2001-12-01

demonstration of the value of international collaboration. ESO and its partner institutes and companies in France and Germany have worked a long time towards this goal - with the first, extremely promising results, we shall soon be able to offer a new and fully tuned instrument to our wide research community." The NAOS adaptive optics corrector was built, under an ESO contract, by Office National d'Etudes et de Recherches Aérospatiales (ONERA) , Laboratoire d'Astrophysique de Grenoble (LAOG) and the DESPA and DASGAL laboratories of the Observatoire de Paris in France, in collaboration with ESO. The CONICA infra-red camera was built, under an ESO contract, by the Max-Planck-Institut für Astronomie (MPIA) (Heidelberg) and the Max-Planck Institut für Extraterrestrische Physik (MPE) (Garching) in Germany, in collaboration with ESO. The present event happens less than four weeks after "First Fringes" were achieved for the VLT Interferometer (VLTI) with two of the 8.2-m Unit Telescopes. No wonder that a spirit of great enthusiasm reigns at Paranal! Information for the media: ESO is producing a Video News Release ( ESO Video News Reel No. 13 ) with sequences from the NAOS-CONICA "First Light" event at Paranal, a computer animation illustrating the principle of adaptive optics in NAOS-CONICA, as well as the first astronomical images obtained. In addition to the usual distribution, this VNR will also be transmitted via satellite Friday 7 December 2001 from 09:00 to 09:15 CET (10:00 to 10:15 UT) on "Europe by Satellite" . These video images may be used free of charge by broadcasters. Satellite details, the script and the shotlist will be on-line from 6 December on the ESA TV Service Website http://television.esa.int. Also a pre-view Real Video Stream of the video news release will be available as of that date from this URL. Video Clip 07/01 : Various video scenes related to the NAOS-CONICA "First Light" Event ( ESO Video News Reel No. 13 ). PR Photo 33a/01 : NAOS-CONICA "First light

The VLT Opening Symposium

Science.gov (United States)

1999-02-01

. The text below summarizes the individual projects. Comprehensive texts with all photos and diagrammes are available in nine separate web documents ( ESO PR Photos 08/99 to 16/99 ) that may be accessed via the links at the top of each section. The degree of detail and level of complexity of the texts depend on the subject and the available materials. 1. Dwarf Galaxies in the Local Group ESO PR Photo 10a/99 ESO PR Photo 10a/99 The Antlia Galaxy (FORS1 colour composite) . Access full text and PR Photos 10a-d/99 In addition to large spiral galaxies like the Milky Way Galaxy, the Andromeda Galaxy and Messier 33, the Local Group of Galaxies contains many dwarf galaxies. The VLT has observed two of these, Antlia and NGC 6822 . Antlia is a low-surface brightness, spheroidal dwarf galaxy that was only discovered in 1997. While it contains a large amount of atomic hydrogen at its centre, no young stars are found, and it appears that most of its stars are old. This is unlike other dwarf galaxies in the Milky Way neighbourhood, as star formation is expected to occur within dense hydrogen clouds. Further observations will be necessary to understand this unusual characteristics. The VLT also obtained images of an irregular dwarf galaxy in the Local Group, NGC 6822, as well as spectra of some of its stars. This galaxy is of the "irregular" type and is situated at a distance of about 2 million light-years. A comparison of the spectra of supergiant stars in NGC 6822 shows that many spectral lines are much weaker than in stars of similar type in the Milky Way, but of similar strength as in stars in the Small Magellanic Cloud. This confirms an earlier finding that NGC 6822 has chemical composition (a lower "metallicity") that is different from what is observed in our Galaxy. 2. The Double Stellar Cluster NGC 1850 in the LMC ESO PR Photo 15/99 ESO PR Photo 15/99 NGC 1850 (FORS1 colour composite) . Access full text and PR Photo 15/99 NGC 1850 is a double cluster in the Large Magellanic

On PR group classes and PR algebra membership

International Nuclear Information System (INIS)

Lebedenko, V.M.

1978-01-01

The necessary and sufficient conditions are found for the membership of Lee algebras to PR algebra class, to algebras with commutation relations of [Hsub(i), Hsub(j)]=rsub(ij)Hsub(i) (i< j) type. Due to this, a criterion is obtained for the membership of the Lee froups to PR group classes, connected and simply connected Lee groups, which Lee algebras are PR algebras

Declaración sobre los índices de citación y las prácticas editoriales

Directory of Open Access Journals (Sweden)

Desde el Jardín de Freud

2016-01-01

Full Text Available Por iniciativa de la Revista chilena de literatura, de la Universidad de Chile, los editores de algunas revistas latinoamericanas nos reunimos el 29 de septiembre del 2014 en Santiago de Chile para discutir políticas comunes y formas de apoyo en nuestra actividad. Los asistentes coincidimos en expresar nuestra inconformidad frente a las formas predominantes de medición de la calidad académica de las publicaciones que, en primer lugar, privilegian criterios administrativos y cuantitativos sobre los contenidos y, en segundo lugar, tienden a ignorar las prácticas académicas propias de las humanidades, que son diferentes a las de las ciencias exactas y aplicadas. Por eso, hemos decidido firmar la siguiente declaración pública, en cuya redacción hemos trabajado durante el primer semestre del 2015.

Neutron Scattering from fcc Pr and Pr3Tl

DEFF Research Database (Denmark)

Birgeneau, R. J.; Als-Nielsen, Jens Aage; Bucher, E.

1972-01-01

Elastic-neutron-scattering measurements on the singlet-ground-state ferromagnets fcc Pr and Pr3 Tl are reported. Both exhibit magnetic phase transitions, possibly to a simple ferromagnetic state at 20 and 11.6 °K, respectively. The transitions appear to be of second order although that in fcc Pr...

UNA PROPUESTA PARA LA MEJORA DE LA ADECUACIÓN EN LA EXPRESIÓN ESCRITA EN LA E.S.O.

Directory of Open Access Journals (Sweden)

Mª del Pilar Mesa Arroyo

2012-01-01

Full Text Available Partiendo de los malos resultados obtenidos por el alumnado andaluz en competencia en comunicación lingüística en las pruebas de diagnóstico efectuadas por la Consejería de Educación de la Junta de Andalucía, y teniendo en cuenta la escasa presencia de actividades de expresión escrita adecuadas en los libros de texto utilizados actualmente en los institutos de educación secundaria de Andalucía; planteamos una propuesta didáctica que, basada en el análisis microfuncional, pretende la mejora de la adecuación de los textos compuestos por alumnado de la ESO. La efectividad de nuestra propuesta se ha comprobado mediante la evaluación de textos compuestos por 40 alumnos de 3º de ESO de dos centros de secundaria andaluces.

A tip / tilt mirror with large dynamic range for the ESO VLT Four Laser Guide Star Facility

NARCIS (Netherlands)

Rijnveld, N.; Henselmans, R.; Nijland, B.A.H.

2011-01-01

One of the critical elements in the Four Laser Guide Star Facility (4LGSF) for the ESO Very Large Telescope (VLT) is the Optical Tube Assembly (OTA), consisting of a stable 20x laser beam expander and an active tip/tilt mirror, the Field Selector Mechanism (FSM). This paper describes the design and

The ESO Diffuse Interstellar Band Large Exploration Survey (EDIBLES)

Science.gov (United States)

Cami, J.; Cox, N. L.; Farhang, A.; Smoker, J.; Elyajouri, M.; Lallement, R.; Bacalla, X.; Bhatt, N. H.; Bron, E.; Cordiner, M. A.; de Koter, A..; Ehrenfreund, P.; Evans, C.; Foing, B. H.; Javadi, A.; Joblin, C.; Kaper, L.; Khosroshahi, H. G.; Laverick, M.; Le Petit, F..; Linnartz, H.; Marshall, C. C.; Monreal-Ibero, A.; Mulas, G.; Roueff, E.; Royer, P.; Salama, F.; Sarre, P. J.; Smith, K. T.; Spaans, M.; van Loon, J. T..; Wade, G.

2018-03-01

The ESO Diffuse Interstellar Band Large Exploration Survey (EDIBLES) is a Large Programme that is collecting high-signal-to-noise (S/N) spectra with UVES of a large sample of O and B-type stars covering a large spectral range. The goal of the programme is to extract a unique sample of high-quality interstellar spectra from these data, representing different physical and chemical environments, and to characterise these environments in great detail. An important component of interstellar spectra is the diffuse interstellar bands (DIBs), a set of hundreds of unidentified interstellar absorption lines. With the detailed line-of-sight information and the high-quality spectra, EDIBLES will derive strong constraints on the potential DIB carrier molecules. EDIBLES will thus guide the laboratory experiments necessary to identify these interstellar “mystery molecules”, and turn DIBs into powerful diagnostics of their environments in our Milky Way Galaxy and beyond. We present some preliminary results showing the unique capabilities of the EDIBLES programme.

"First Light" for HARPS at La Silla

Science.gov (United States)

2003-03-01

"First Light" for HARPS at La Silla Advanced Planet-Hunting Spectrograph Passes First Tests With Flying Colours Summary The initial commissioning period of the new HARPS spectrograph (High Accuracy Radial Velocity Planet Searcher) of the 3.6-m telescope at the ESO La Silla Observatory has been successfully accomplished in the period February 11 - 27, 2003. This new instrument is optimized to detect planets in orbit around other stars ("exoplanets") by means of accurate (radial) velocity measurements with an unequalled precision of 1 meter per second . This high sensitivity makes it possible to detect variations in the motion of a star at this level, caused by the gravitational pull of one or more orbiting planets, even relatively small ones. "First Light" occurred on February 11, 2003, during the first night of tests. The instrument worked flawlessly and was fine-tuned during subsequent nights, achieving the predicted performance already during this first test run. The measurement of accurate stellar radial velocities is a very efficient way to search for planets around other stars. More than one hundred extrasolar planets have so far been detected , providing an increasingly clear picture of a great diversity of exoplanetary systems . However, current technical limitations have so far prevented the discovery around solar-type stars of exoplanets that are much less massive than Saturn, the second-largest planet in the solar system. HARPS will break through this barrier and will carry this fundamental exploration towards detection of exoplanets with masses like Uranus and Neptune. Moreover, in the case of low-mass stars - like Proxima Centauri, cf. ESO PR 05/03 - HARPS will have the unique capability to detect big "telluric" planets with only a few times the mass of the Earth . The HARPS instrument is being offered to the research community in the ESO member countries, already from October 2003 . PR Photo 08a/03 : The large optical grating of the HARPS spectrograph

Another Look at an Enigmatic New World

Science.gov (United States)

2005-02-01

VLT NACO Performs Outstanding Observations of Titan's Atmosphere and Surface On January 14, 2005, the ESA Huygens probe arrived at Saturn's largest satellite, Titan. After a faultless descent through the dense atmosphere, it touched down on the icy surface of this strange world from where it continued to transmit precious data back to the Earth. Several of the world's large ground-based telescopes were also active during this exciting event, observing Titan before and near the Huygens encounter, within the framework of a dedicated campaign coordinated by the members of the Huygens Project Scientist Team. Indeed, large astronomical telescopes with state-of-the art adaptive optics systems allow scientists to image Titan's disc in quite some detail. Moreover, ground-based observations are not restricted to the limited period of the fly-by of Cassini and landing of Huygens. They hence complement ideally the data gathered by this NASA/ESA mission, further optimising the overall scientific return. A group of astronomers [1] observed Titan with ESO's Very Large Telescope (VLT) at the Paranal Observatory (Chile) during the nights from 14 to 16 January, by means of the adaptive optics NAOS/CONICA instrument mounted on the 8.2-m Yepun telescope [2]. The observations were carried out in several modes, resulting in a series of fine images and detailed spectra of this mysterious moon. They complement earlier VLT observations of Titan, cf. ESO Press Photos 08/04 and ESO Press Release 09/04. The highest contrast images ESO PR Photo 04a/05 ESO PR Photo 04a/05 Titan's surface (NACO/VLT) [Preview - JPEG: 400 x 712 pix - 64k] [Normal - JPEG: 800 x 1424 pix - 524k] ESO PR Photo 04b/05 ESO PR Photo 04b/05 Map of Titan's Surface (NACO/VLT) [Preview - JPEG: 400 x 651 pix - 41k] [Normal - JPEG: 800 x 1301 pix - 432k] Caption: ESO PR Photo 04a/05 shows Titan's trailing hemisphere [3] with the Huygens landing site marked as an "X". The left image was taken with NACO and a narrow-band filter

Isothermal sections of the state diagram for the Pr-Ni-Ge system at 870 (0-0,5Pr) and 670 K (0,5-1Pr)

International Nuclear Information System (INIS)

Fedyna, M.F.; Pecharskij, V.K.; Bodak, O.I.

1987-01-01

Method of X-ray phase and microstructural analyses were used to study Pr-Ni-Ge ternary system at 870K (0-0.50 at.fractions of Pr) and 670K (0.50-1.00 at.fractions of Pr). 11 ternary compounds exist in the system: Pr 1-x (NiGe) 13 (x=0.24), PrNi 2 Ge 2 , Pr 2 Ni 3 Ge 5 , PrNiGe 3 , Pr 2 NiGe 6 , Pr 3 Ni 4 Ge 4 , PrNi (1-x) Ge 2 (x=0.33), PrNiGe, Pr(NiGe) 2-x (x=0.14), Pr 3 NiGe 2 , ∼Pr 5 NiGe 4 . Crystal structure was determined for seven ternary compounds

The Gaia-ESO Survey: double-, triple-, and quadruple-line spectroscopic binary candidates

Science.gov (United States)

Merle, T.; Van Eck, S.; Jorissen, A.; Van der Swaelmen, M.; Masseron, T.; Zwitter, T.; Hatzidimitriou, D.; Klutsch, A.; Pourbaix, D.; Blomme, R.; Worley, C. C.; Sacco, G.; Lewis, J.; Abia, C.; Traven, G.; Sordo, R.; Bragaglia, A.; Smiljanic, R.; Pancino, E.; Damiani, F.; Hourihane, A.; Gilmore, G.; Randich, S.; Koposov, S.; Casey, A.; Morbidelli, L.; Franciosini, E.; Magrini, L.; Jofre, P.; Costado, M. T.; Jeffries, R. D.; Bergemann, M.; Lanzafame, A. C.; Bayo, A.; Carraro, G.; Flaccomio, E.; Monaco, L.; Zaggia, S.

2017-12-01

Context. The Gaia-ESO Survey (GES) is a large spectroscopic survey that provides a unique opportunity to study the distribution of spectroscopic multiple systems among different populations of the Galaxy. Aims: Our aim is to detect binarity/multiplicity for stars targeted by the GES from the analysis of the cross-correlation functions (CCFs) of the GES spectra with spectral templates. Methods: We developed a method based on the computation of the CCF successive derivatives to detect multiple peaks and determine their radial velocities, even when the peaks are strongly blended. The parameters of the detection of extrema (DOE) code have been optimized for each GES GIRAFFE and UVES setup to maximize detection. The DOE code therefore allows to automatically detect multiple line spectroscopic binaries (SBn, n ≥ 2). Results: We apply this method on the fourth GES internal data release and detect 354 SBn candidates (342 SB2, 11 SB3, and even one SB4), including only nine SBs known in the literature. This implies that about 98% of these SBn candidates are new because of their faint visual magnitude that can reach V = 19. Visual inspection of the SBn candidate spectra reveals that the most probable candidates have indeed a composite spectrum. Among the SB2 candidates, an orbital solution could be computed for two previously unknown binaries: CNAME 06404608+0949173 (known as V642 Mon) in NGC 2264 and CNAME 19013257-0027338 in Berkeley 81 (Be 81). A detailed analysis of the unique SB4 (four peaks in the CCF) reveals that CNAME 08414659-5303449 (HD 74438) in the open cluster IC 2391 is a physically bound stellar quadruple system. The SB candidates belonging to stellar clusters are reviewed in detail to discard false detections. We suggest that atmospheric parameters should not be used for these system components; SB-specific pipelines should be used instead. Conclusions: Our implementation of an automatic detection of spectroscopic binaries within the GES has allowed the

Entre la autonomía y la heteronomía.Socialización universitaria y prácticas profesionales de los sociólogos en la Argentina

Directory of Open Access Journals (Sweden)

Juan Pedro Blois

2013-01-01

Full Text Available Este artículo analiza la relación entre socialización universitaria y prácticas profesionales de los sociólogos en Argentina desde el regreso de la democracia. Por un lado, examina las orientaciones y formas de entender la disciplina transmitidas por la Carrera de Sociología de la Universidad de Buenos Aires y, por el otro, reconstruye los principales cambios ocurridos en el mercado de trabajo. A partir del examen de la noción de autonomía (y su par opuesto, la heteronomía, se propone mostrar que las prácticas profesionales de los sociólogos están fuertemente condicionadas por el conjunto de esquemas de percepción y clasificación incorporados durante la socialización universitaria. En la medida en que esos esquemas operan a partir de una serie de oposiciones, contribuyen a la producción de un conjunto de “oficios” o modos de practicar la sociología claramente diferenciados según el área o esfera de inserción.

Photoemission of heavy fermion superconductor PrOs4Sb12 and other Pr compounds

International Nuclear Information System (INIS)

Imada, S.; Yamasaki, A.; Sekiyama, A.; Settai, R.; Onuki, Y.; Suga, S.; Sugawara, H.; Sato, H.; Ochiai, A.

2004-01-01

Full text: Strongly correlated electronic states due to Pr 4f electrons found in several Pr compounds have recently been attracting much attention. The Pr 4f electrons are much more localized than in Ce due to the lanthanoid contraction. Therefore, the number of the Pr systems that show strong electron correlation is much smaller than Ce systems. We will present a comparative study of Pr 4f electronic states in such systems as the heavy fermion superconductor PrOs 4 Sb 12 , the Kondo system PrSn 3 and the localized 4f systems Pr 4 X 3 (X = Sb and Bi). The Pr 4f electronic state was probed by means of the Pr 3d → 4f resonant photoemission (RPES). Because the kinetic energy (E K ) of the photoelectrons is as high as ∼ 900 eV, this method is much more bulk sensitive than the 4d → 4f RPES with E K ∼ 100 eV. The energy resolution could be set to about 100 meV by utilizing the soft X-rays from BL25SU in SPring-8 and the SCIENTA SES-200 analyzer. The Pr 4f excitation spectrum of PrSn 3 was found to show a very strong intensity at the Fermi level (E F ). This can be interpreted as the Kondo resonance which has been observed in the Kondo Ce and Yb compounds. In the Pr 4f spectrum of the heavy fermion superconductor PrOs 4 Sb 12 , the intensity at E F was smaller than in PrSn 3 . This clearly shows that the Kondo temperature (T K ) is much lower in PrOs 4 Sb 12 than in PrSn 3 . We have further found a strong excitation energy dependence in the RPES line shape. In the case of Pr 4 X 3 (X = Sb and Bi), the intensity at E B was much smaller than PrSn 3 and PrOs 4 Sb 12 , which is consistent with the localized character of Pr 4f electrons in Pr 4 X 3 . The Pr 4f spectra of these localized systems are qualitatively well reproduced by a cluster model calculation that takes into account the hybridization between the Pr 4f orbital and the conduction and valence bands made up by the X p and Pr 5d states

A new mix of power for the ESO installations in Chile: greener, more reliable, cheaper

Science.gov (United States)

Filippi, G.; Tamai, R.; Kalaitzoglou, D.; Wild, W.; Delorme, A.; Rioseco, D.

2016-07-01

The highest sky quality demands for astronomical research impose to locate observatories often in areas not easily reached by the existing power infrastructures. At the same time, availability and cost of power is a primary factor for sustainable operations. Power may also be a potential source for CO2 pollution. As part of its green initiatives, ESO is in the process of replacing the power sources for its own, La Silla and Paranal-Armazones, and shared, ALMA, installations in Chile in order to provide them with more reliable, affordable, and smaller CO2 footprint power solutions. The connectivity to the Chilean interconnected power systems (grid) which is to extensively use Non-Conventional Renewable Energy (NCRE) as well as the use of less polluting fuels wherever self-generation cannot be avoided are key building blocks for the solutions selected for every site. In addition, considerations such as the environmental impact and - if required - the partnership with other entities have also to be taken into account. After years of preparatory work to which the Chilean Authorities provided great help and support, ESO has now launched an articulated program to upgrade the existing agreements/facilities in i) the La Silla Observatory, from free to regulated grid client status due to an agreement with a Solar Farm private initiative, in ii) the Paranal-Armazones Observatory, from local generation using liquefied petroleum gas (LPG) to connection to the grid which is to extensively use NCRE, and last but not least, in iii) the ALMA Observatory where ESO participates together with North American and East Asian partners, from replacing the LPG as fuel for the turbine local generation system with the use of less polluting natural gas (NG) supplied by a pipe connection to eliminate the pollution caused by the LPG trucks (currently 1 LPG truck from the VIII region, Bio Bio, to the II region, ALMA and back every day, for a total of 3000km). The technologies used and the status

Suured prügifirmad valmistuvad prügipuuduseks / Mirko Ojakivi

Index Scriptorium Estoniae

Ojakivi, Mirko

2010-01-01

Ragn-Sells ja Adelan Prügiveod soovivad luba jäätmete pikaajaliseks vaheladestamiseks Tallinna piiril. Ragn-Sells saaks jäätmekütusetehase planeerimise ja ehitamise ajal endale koguda ligi 35 000 t segaolmejäätmeid aastas, Adelan Prügiveod sooviks ladestada ligi 50 000 t prügi aastas

Characterizing TW Hydra

Science.gov (United States)

Sokal, Kimberly R.; Deen, Casey P.; Mace, Gregory N.; Lee, Jae-Joon; Oh, Heeyoung; Kim, Hwihyun; Kidder, Benjamin T.; Jaffe, Daniel T.

2018-02-01

At 60 pc, TW Hydra (TW Hya) is the closest example of a star with a gas-rich protoplanetary disk, though TW Hya may be relatively old (3–15 Myr). As such, TW Hya is especially appealing for testing our understanding of the interplay between stellar and disk evolution. We present a high-resolution near-infrared spectrum of TW Hya obtained with the Immersion GRating INfrared Spectrometer (IGRINS) to re-evaluate the stellar parameters of TW Hya. We compare these data to synthetic spectra of magnetic stars produced by MoogStokes, and use sensitive spectral line profiles to probe the effective temperature, surface gravity, and magnetic field. A model with {T}{eff}=3800 K, {log} g=4.2, and B=3.0 kG best fits the near-infrared spectrum of TW Hya. These results correspond to a spectral type of M0.5 and an age of 8 Myr, which is well past the median life of gaseous disks.

Multiple Eyes for the VLT

Science.gov (United States)

2002-01-01

First System of Deployable Multi-Integral Field Units Ready Summary The ESO Very Large Telescope (VLT) at the Paranal Observatory is being equipped with many state-of-the-art astronomical instruments that will allow observations in a large number of different modes and wavebands. Soon to come is the Fibre Large Array Multi-Element Spectrograph (FLAMES) , a project co-ordinated by ESO. It incorporates several complex components, now being constructed at various research institutions in Europe and Australia. One of these, a true technological feat, is a unique system of 15 deployable fibre bundles, the so-called Integral Field Units (IFUs) . They can be accurately positioned within a sky field-of-view measuring no less that 25 arcmin in diameter, i.e., almost as large as the full Moon . Each of the IFUs looks like an insect's eye and images a small sky area (3 x 2 arcsec 2 ) with a multiple microlens. From each IFU, 20 narrow light beams are sent via optical fibres to an advanced spectrograph. All 300 spectra are recorded simultaneously by a sensitive digital camera. A major advantage of this technique is that, contrary usual spectroscopic observations in which spectral information is obtained along a (one-dimensional) line on the sky, it now allows (two-dimensional) area spectroscopy . This will permit extremely efficient spectral observations of many celestial objects, including faint galaxies, providing detailed information about their internal structure and motions. Such studies will have an important impact on our understanding, e.g., of the early evolution of galaxies , the main building blocks in the Universe. The IFUs have been developed by a team of astronomers and engineers [2] at the Observatoire de Paris-Meudon. All IFU components are now at the ESO Headquarters in Garching (Germany) where they are being checked and integrated into the instrument [3]. PR Photo 03a/02 : The GIRAFFE spectrograph in the ESO Assembly Hall (Garching, Germany) . PR Photo 03b/02

Crystal Field Levels of Pr3+ in PrFeO3 and PrGaO3 Determined by Inelastic Neutron Scattering

DEFF Research Database (Denmark)

Feldmann, K.; Henning, K.; Kaun, L.

1975-01-01

The crystal field splitting of the 3H4 ground state of the Pr ion in PrFeO3 and PrGaO3 has been investigated by inelastic scattering of thermal neutrons. At several temperatures the transitions have been measured by TAS and TOF methods for polycrystalline PrFeO3 and by the TOF method...... for polycrystalline PrGaO3. Energy level schemes which are different for these materials are given....

PrP N-terminal domain triggers PrPSc-like aggregation of Dpl

International Nuclear Information System (INIS)

Erlich, Paul; Cesbron, Jean-Yves; Lemaire-Vieille, Catherine; Curt, Aurelie; Andrieu, Jean-Pierre; Schoehn, Guy; Jamin, Marc; Gagnon, Jean

2008-01-01

Transmissible spongiform encephalopathies are fatal neurodegenerative disorders thought to be transmitted by self-perpetuating conformational conversion of a neuronal membrane glycoprotein (PrP C , for 'cellular prion protein') into an abnormal state (PrP Sc , for 'scrapie prion protein'). Doppel (Dpl) is a protein that shares significant biochemical and structural homology with PrP C . In contrast to its homologue PrP C , Dpl is unable to participate in prion disease progression or to achieve an abnormal PrP Sc -like state. We have constructed a chimeric mouse protein, composed of the N-terminal domain of PrP C (residues 23-125) and the C-terminal part of Dpl (residues 58-157). This chimeric protein displays PrP-like biochemical and structural features; when incubated in presence of NaCl, the α-helical monomer forms soluble β-sheet-rich oligomers which acquire partial resistance to pepsin proteolysis in vitro, as do PrP oligomers. Moreover, the presence of aggregates akin to protofibrils is observed in soluble oligomeric species by electron microscopy

Bi3+–Pr3+ energy transfer processes and luminescent properties of LuAG:Bi,Pr and YAG:Bi,Pr single crystalline films

International Nuclear Information System (INIS)

Zorenko, Y.; Gorbenko, V.; Savchyn, V.; Zorenko, T.; Nikl, M.; Mares, J.A.; Beitlerova, A.; Jary, V.

2013-01-01

Absorption, cathodoluminescence, excitation spectra of photoluminescence (PL) and PL decay kinetics were studied at 300 K for the double doped with Bi 3+ –Pr 3+ and separately doped with Bi 3+ and Pr 3+ Lu 3 Al 5 O 12 (LuAG) and Y 3 Al 5 O 12 (YAG) single crystalline film (SCF) phosphors grown by the liquid phase epitaxy method. The emission bands in the UV range arising from the intrinsic radiative transitions of Bi 3+ based centers, and emission bands in the visible range, related to the luminescence of excitons localized around Bi 3+ based centers, were identified both in Bi–Pr and Bi-doped LuAG and YAG SCFs. The energy transfer processes from the host lattice simultaneously to Bi 3+ and Pr 3+ ions and from Bi 3+ to Pr 3+ ions were investigated. Competition between Pr 3+ and Bi 3+ ions in the energy transfer processes from the LuAG and YAG hosts was evidenced. The strong decrease of the intensity of Pr 3+ luminescence both in LuAG:Pr and YAG:Pr SCFs phosphors, grown from Bi 2 O 3 flux, is observed due to the quenching influence of Bi 3+ flux related impurity. Due to overlap of the UV emission band of Bi 3+ centers with the f–d absorption bands of Pr 3+ ions in the UV range and the luminescence of excitons localized around Bi ions with the f–f absorption bands of Pr 3+ ions in the visible range, an effective energy transfer from Bi 3+ ions to Pr 3+ ions takes place in LuAG:Bi,Pr and YAG:Bi,Pr SCFs, resulting in the appearance of slower component in the decay kinetics of the Pr 3+ d–f luminescence. -- Highlights: • Bi and Pr doped film phosphor grown by liquid phase epitaxy method. • Energy transfer from Bi 3+ to Pr 3+ ions. • Strong quenching of the Pr 3+ luminescence by Bi 3+ co-dopant

Feeling the Heat

Science.gov (United States)

2004-05-01

Successful "First Light" for the Mid-Infrared VISIR Instrument on the VLT Summary Close to midnight on April 30, 2004, intriguing thermal infrared images of dust and gas heated by invisible stars in a distant region of our Milky Way appeared on a computer screen in the control room of the ESO Very Large Telescope (VLT). These images mark the successful "First Light" of the VLT Imager and Spectrometer in the InfraRed (VISIR), the latest instrument to be installed on this powerful telescope facility at the ESO Paranal Observatory in Chile. The event was greeted with a mixture of delight, satisfaction and some relief by the team of astronomers and engineers from the consortium of French and Dutch Institutes and ESO who have worked on the development of VISIR for around 10 years [1]. Pierre-Olivier Lagage (CEA, France), the Principal Investigator, is content : "This is a wonderful day! A result of many years of dedication by a team of engineers and technicians, who can today be proud of their work. With VISIR, astronomers will have at their disposal a great instrument on a marvellous telescope. And the gain is enormous; 20 minutes of observing with VISIR is equivalent to a whole night of observing on a 3-4m class telescope." Dutch astronomer and co-PI Jan-Willem Pel (Groningen, The Netherlands) adds: "What's more, VISIR features a unique observing mode in the mid-infrared: spectroscopy at a very high spectral resolution. This will open up new possibilities such as the study of warm molecular hydrogen most likely to be an important component of our galaxy." PR Photo 16a/04: VISIR under the Cassegrain focus of the Melipal telescope PR Photo 16b/04: VISIR mounted behind the mirror of the Melipal telescope PR Photo 16c/04: Colour composite of the star forming region G333.6-0.2 PR Photo 16d/04: Colour composite of the Galactic Centre PR Photo 16e/04: The Ant Planetary Nebula at 12.8 μm PR Photo 16f/04: The starburst galaxy He2-10 at 11.3μm PR Photo 16g/04: High

Upgrade of ESO's FIERA CCD Controller and PULPO Subsystem

Science.gov (United States)

Reyes-Moreno, J.; Geimer, C.; Balestra, A.; Haddad, N.

An overview of FIERA is presented with emphasis on its recent upgrade to PCI. The PCI board hosts two DSPs, one for real time control of the camera and another for on-the-fly processing of the incoming video data. In addition, the board is able to make DMA transfers, to synchronize to other boards alike, to be synchronized by a TIM bus and to control PULPO via RS232. The design is based on the IOP480 chip from PLX, for which we have developed a device driver for both Solaris and Linux. One computer is able to host more than one board and therefore can control an array of FIERA detector electronics. PULPO is a multifunctional subsystem widely used at ESO for the housekeeping of CCD cryostat heads and for shutter control. The upgrade of PULPO is based on an embedded PC running Linux. The upgraded PULPO is able to handle 29 temperature sensors, control 8 heaters and one shutter, read out one vacuum sensor and log any combination of parameters.

Structure and Dynamics of the Accretion Process and Wind in TW Hya

Science.gov (United States)

Dupree, A. K.; Brickhouse, N. S.; Cranmer, S. R.; Berlind, P.; Strader, Jay; Smith, Graeme H.

2014-07-01

Time-domain spectroscopy of the classical accreting T Tauri star, TW Hya, covering a decade and spanning the far UV to the near-infrared spectral regions can identify the radiation sources, the atmospheric structure produced by accretion, and properties of the stellar wind. On timescales from days to years, substantial changes occur in emission line profiles and line strengths. Our extensive time-domain spectroscopy suggests that the broad near-IR, optical, and far-uv emission lines, centered on the star, originate in a turbulent post-shock region and can undergo scattering by the overlying stellar wind as well as some absorption from infalling material. Stable absorption features appear in Hα, apparently caused by an accreting column silhouetted in the stellar wind. Inflow of material onto the star is revealed by the near-IR He I 10830 Å line, and its free-fall velocity correlates inversely with the strength of the post-shock emission, consistent with a dipole accretion model. However, the predictions of hydrogen line profiles based on accretion stream models are not well-matched by these observations. Evidence of an accelerating warm to hot stellar wind is shown by the near-IR He I line, and emission profiles of C II, C III, C IV, N V, and O VI. The outflow of material changes substantially in both speed and opacity in the yearly sampling of the near-IR He I line over a decade. Terminal outflow velocities that range from 200 km s-1 to almost 400 km s-1 in He I appear to be directly related to the amount of post-shock emission, giving evidence for an accretion-driven stellar wind. Calculations of the emission from realistic post-shock regions are needed. Data presented herein were obtained at the W. M. Keck Observatory, which is operated as a scientific partnership among the California Institute of Technology, the University of California, and the National Aeronautics and Space Administration. The Observatory was made possible by the generous financial support

Prácticas, representaciones y discursos de corporalidad: La ambigüedad en los cuerpos circenses Práticas, representações e discursos da corporalidade: A ambigüidade nos corpos do circo Practices, representations and discourses of the body: Ambiguity on circus bodies

Directory of Open Access Journals (Sweden)

Julieta Infantino

2010-06-01

Full Text Available En este artículo trabajaremos con las prácticas de los artistas circenses contemporáneos en la ciudad de Buenos Aires. Abordaremos los modos en los que la corporalidad se constituye en uno de los medios de expresión identitaria en tanto un grupo social puede componer, a través de sus experiencias corporales, sus propios estilos artísticos, su propia definición de práctica artístico-laboral, su propio cuerpo legítimo. Mostraremos la manera en que esos cuerpos pueden por momentos disputar y/o reproducir concepciones hegemónicas de corporalidad, proponiendo la necesidad de pensar estos procesos de manera dinámica, prestando atención tanto a los mecanismos de poder como a su contraparte, los sujetos que negocian, cuestionan y/o resisten.Este artigo versa sobre as práticas de artistas de circo contemporâneo na cidade de Buenos Aires. Abordam-se os modos em que as corporalidades se constituem em vias de expressão da identidade de um grupo social que pode criar, através de experiências corporais, seus próprios estilos artísticos, suas definições das práticas artístico-laborais, e seu próprio corpo legítimo. O trabalho busca mostrar como estes corpos podem, às vezes, contestar e/ou reproduzir concepções corporais hegemônicas, propondo a necessidade de se pensar estes processos de modo dinâmico, analisando tanto os mecanismos de poder e sua contrapartida, as práticas de sujeitos que negociam, questionam e/ou resistem.This paper will work the practices of contemporary circus artists in the city of Buenos Aires. We will analyse the way in which corporality can become one of the means of identity expression, given that a social group can compose, through body experiences, its own artistic styles, its own definition of artistic-labour practices, its own legitimate body. We will show how these bodies can at times dispute or reproduce hegemonic conceptions of corporality. We suggest there is a need of thinking these processes in

PillCam ESO in esophageal studies: improved diagnostic yield of 14 frames per second (fps) compared with 4 fps.

Science.gov (United States)

Koslowsky, B; Jacob, H; Eliakim, R; Adler, S N

2006-01-01

Capsule endoscopy, using the PillCam ESO and sending images at a rate of 4 frames per second (fps), has a high sensitivity and specificity in diagnosing gastroesophageal reflux disease (GERD) lesions. We tested a new device which produces images at a rate of 14 fps. The diagnostic performance and esophageal visualization of these two devices were compared. 42 patients with GERD symptoms and eight patients with a history of Barrett's esophagus had an esophagogastroduodenoscopy (EGD). All patients underwent capsule endoscopy of the esophagus within 1 hour prior to EGD. The first 25 patients had a capsule endoscopy examination with the 4-fps device. The following 25 patients underwent capsule endoscopy under identical conditions but using the 14-fps device. The reader of the capsule endoscopy study was blinded to the EGD findings. A diagnosis of GERD or Barrett's esophagus was established with EGD. The findings at capsule endoscopy were compared with the EGD findings. We also examined how frequently the esophagus in its entirety was visualized by these two devices. The 4-fps device diagnosed 16/19 cases of esophageal erosions or ulcers (sensitivity 84 %) and 6/8 cases of Barrett's esophagus (sensitivity 75 %). The 14-fps capsule diagnosed 16/16 cases of esophageal ulcers or erosions and 7/7 cases of Barrett's esophagus (sensitivity 100 %). The total diagnostic miss rate in the 4-fps group was 5/27 (18 %) whereas the diagnostic miss rate in the 14-fps group was 0/23 (0 %) P fps group and in 20/25 patients (80 %) in the 14-fps group ( P fps device and in 19/25 (76 %) by the 14-fps device ( P fps PillCam ESO capsule is consistent with the data obtained from fluoroscopic studies of swallowed PillCam capsules, showing that capsule speed may reach 20 cm/s. For the 14-fps PillCam this means one image transmitted per 3-cm segment at maximal capsule speed, therefore still allowing for full visualization of the entire esophagus. Capsule endoscopy using the 14-fps PillCam ESO

The Gaia-ESO Survey: Exploring the complex nature and origins of the Galactic bulge populations

Science.gov (United States)

Rojas-Arriagada, A.; Recio-Blanco, A.; de Laverny, P.; Mikolaitis, Š.; Matteucci, F.; Spitoni, E.; Schultheis, M.; Hayden, M.; Hill, V.; Zoccali, M.; Minniti, D.; Gonzalez, O. A.; Gilmore, G.; Randich, S.; Feltzing, S.; Alfaro, E. J.; Babusiaux, C.; Bensby, T.; Bragaglia, A.; Flaccomio, E.; Koposov, S. E.; Pancino, E.; Bayo, A.; Carraro, G.; Casey, A. R.; Costado, M. T.; Damiani, F.; Donati, P.; Franciosini, E.; Hourihane, A.; Jofré, P.; Lardo, C.; Lewis, J.; Lind, K.; Magrini, L.; Morbidelli, L.; Sacco, G. G.; Worley, C. C.; Zaggia, S.

2017-05-01

Context. As observational evidence steadily accumulates, the nature of the Galactic bulge has proven to be rather complex: the structural, kinematic, and chemical analyses often lead to contradictory conclusions. The nature of the metal-rich bulge - and especially of the metal-poor bulge - and their relation with other Galactic components, still need to be firmly defined on the basis of statistically significant high-quality data samples. Aims: We used the fourth internal data release of the Gaia-ESO survey to characterize the bulge metallicity distribution function (MDF), magnesium abundance, spatial distribution, and correlation of these properties with kinematics. Moreover, the homogeneous sampling of the different Galactic populations provided by the Gaia-ESO survey allowed us to perform a comparison between the bulge, thin disk, and thick disk sequences in the [Mg/Fe] vs. [Fe/H] plane in order to constrain the extent of their eventual chemical similarities. Methods: We obtained spectroscopic data for 2500 red clump stars in 11 bulge fields, sampling the area -10° ≤ l ≤ + 8° and -10° ≤ b ≤ -4° from the fourth internal data release of the Gaia-ESO survey. A sample of 6300 disk stars was also selected for comparison. Spectrophotometric distances computed via isochrone fitting allowed us to define a sample of stars likely located in the bulge region. Results: From a Gaussian mixture models (GMM) analysis, the bulge MDF is confirmed to be bimodal across the whole sampled area. The relative ratio between the two modes of the MDF changes as a function of b, with metal-poor stars dominating at high latitudes. The metal-rich stars exhibit bar-like kinematics and display a bimodality in their magnitude distribution, a feature which is tightly associated with the X-shape bulge. They overlap with the metal-rich end of the thin disk sequence in the [Mg/Fe] vs. [Fe/H] plane. On the other hand, metal-poor bulge stars have a more isotropic hot kinematics and do

O Psicólogo apoiador matricial: percepções e práticas na atenção básica El Psicólogo apoyador matricial: percepciones y prácticas en la atención básica The matrix support Psychologist: perceptions and practices in primary health care

Directory of Open Access Journals (Sweden)

Francisca Marina de Souza Freire

2013-01-01

Full Text Available Buscando nortear novas práticas em saúde, surge a proposta do apoio matricial como um arranjo organizacional cujo objetivo é fazer que uma equipe multiprofissional leve suporte assistencial e técnicopedagógico às equipes que compõem a Estratégia Saúde da Família. Observa-se a crescente inserção do psicólogo nesses serviços em virtude das dificuldades apresentadas pelos profissionais da Saúde da Família no lidar com as questões que envolvem a saúde mental dos usuários. Este estudo, de caráter descritivo, teve por objetivo verificar a percepção que os psicólogos apoiadores matriciais possuem sobre suas atividades e se estas correspondem às diretrizes estabelecidas pelo SUS. Foram entrevistados 10 psicólogos, com idade entre 23 e 45 anos. Os resultados mostraram que, apesar de haver tendência para adoção de novas práticas, os psicólogos ainda apresentam crenças e práticas enraizadas no modelo biomédico. O apoio matricial como dispositivo de mudança ainda não está bem compreendido por esses profissionais, o que demonstra que ainda há um longo caminho a percorrer nesse sentido.Buscando nortear nuevas prácticas en salud, surge la propuesta del apoyo matricial como un arreglo organizacional cuyo objetivo es hacer que un equipo multiprofesional lleve soporte asistencial y técnico pedagógico a los equipos que componen la Estrategia Salud de la Familia. Se observa la creciente inserción del psicólogo en esos servicios en virtud de las dificultades presentadas por los profesionales de la Salud de la Familia en el lidiar con las cuestiones que involucran la salud mental de los usuarios. Este estudio, de carácter descriptivo, tuvo como objetivo verificar la percepción que los psicólogos apoyadores matriciales poseen sobre sus actividades y si éstas corresponden a las directrices establecidas por el SUS. Fueron entrevistados 10 psicólogos, con edad entre 23 y 45 años. Los resultados mostraron que, a pesar de

Prácticas de Governanza Corporativa Indicadas para Monitorazición: Un Análisis del Nivel de Adopción en Coopertivas Agropecuarias.

Directory of Open Access Journals (Sweden)

Luciana Cardoso Siqueira

2014-03-01

Full Text Available La propiedad dispersa implica la delegación del derecho de tomada de decisión de los diversos propietarios a otros agentes, entre los cuales consejos y gestores. Por el hecho de que los diversos agentes se relacionan por medio de contratos incompletos, las decisiones posteriores al contrato deben ser controladas y monitoreadas con foco en una mejor performance. Es en ese contexto que se hace relevante el análisis de las prácticas que guían el sistema que gobierna las acciones de esos agentes. La presente investigación analiza el nivel de adopción de las prácticas de gobernanza corporativa en 27 cooperativas agropecuarias de los Estados de Minas Gerais y São Paulo. Mediante la aplicación de un cuestionario elaborado a partir de las indicaciones de los códigos de gobernanza del Instituto Brasileño de Gobernanza Corporativa (IBGC y de la Organisation for Economic Cooperation and Development (OECD a los mecanismos de monitoreo, fue posible verificar que no existe una tendencia de adopción de las llamadas mejores prácticas de gobernanza indicadas por los respectivos códigos. Se observó, sin embargo, que la estructura de gobernanza y monitoreo de las cooperativas se limita al modelo establecido legalmente, hecho que puede impactar el estilo de tomada de decisión de los gestores.

European Stroke Organisation (ESO) guidelines for the management of spontaneous intracerebral hemorrhage

DEFF Research Database (Denmark)

Steiner, Thorsten; Al-Shahi Salman, Rustam; Beer, Ronnie

2014-01-01

graduated compression stockings, using intermittent pneumatic compression in immobile patients, and using blood pressure lowering for secondary prevention. We found moderate-quality evidence to support weak recommendations for intensive lowering of systolic blood pressure to ...BACKGROUND: Intracerebral hemorrhage (ICH) accounted for 9% to 27% of all strokes worldwide in the last decade, with high early case fatality and poor functional outcome. In view of recent randomized controlled trials (RCTs) of the management of ICH, the European Stroke Organisation (ESO) has...... Assessment, Development and Evaluation (GRADE) approach. RESULTS: We found moderate- to high-quality evidence to support strong recommendations for managing patients with acute ICH on an acute stroke unit, avoiding hemostatic therapy for acute ICH not associated with antithrombotic drug use, avoiding...

Interaction between Shadoo and PrP Affects the PrP-Folding Pathway.

Science.gov (United States)

Ciric, Danica; Richard, Charles-Adrien; Moudjou, Mohammed; Chapuis, Jérôme; Sibille, Pierre; Daude, Nathalie; Westaway, David; Adrover, Miguel; Béringue, Vincent; Martin, Davy; Rezaei, Human

2015-06-01

Prion diseases are characterized by conformational changes of a cellular prion protein (PrP(C)) into a β-sheet-enriched and aggregated conformer (PrP(Sc)). Shadoo (Sho), a member of the prion protein family, is expressed in the central nervous system (CNS) and is highly conserved among vertebrates. On the basis of histoanatomical colocalization and sequence similarities, it is suspected that Sho and PrP may be functionally related. The downregulation of Sho expression during prion pathology and the direct interaction between Sho and PrP, as revealed by two-hybrid analysis, suggest a relationship between Sho and prion replication. Using biochemical and biophysical approaches, we demonstrate that Sho forms a 1:1 complex with full-length PrP with a dissociation constant in the micromolar range, and this interaction consequently modifies the PrP-folding pathway. Using a truncated PrP that mimics the C-terminal C1 fragment, an allosteric binding behavior with a Hill number of 4 was observed, suggesting that at least a tetramerization state occurs. A cell-based prion titration assay performed with different concentrations of Sho revealed an increase in the PrP(Sc) conversion rate in the presence of Sho. Collectively, our observations suggest that Sho can affect the prion replication process by (i) acting as a holdase and (ii) interfering with the dominant-negative inhibitor effect of the C1 fragment. Since the inception of the prion theory, the search for a cofactor involved in the conversion process has been an active field of research. Although the PrP interactome presents a broad landscape, candidates corresponding to specific criteria for cofactors are currently missing. Here, we describe for the first time that Sho can affect PrP structural dynamics and therefore increase the prion conversion rate. A biochemical characterization of Sho-PrP indicates that Sho acts as an ATP-independent holdase. Copyright © 2015, American Society for Microbiology. All Rights

Recombinant PrPSc shares structural features with brain-derived PrPSc: Insights from limited proteolysis.

Science.gov (United States)

Sevillano, Alejandro M; Fernández-Borges, Natalia; Younas, Neelam; Wang, Fei; R Elezgarai, Saioa; Bravo, Susana; Vázquez-Fernández, Ester; Rosa, Isaac; Eraña, Hasier; Gil, David; Veiga, Sonia; Vidal, Enric; Erickson-Beltran, Melissa L; Guitián, Esteban; Silva, Christopher J; Nonno, Romolo; Ma, Jiyan; Castilla, Joaquín; R Requena, Jesús

2018-01-01

Very solid evidence suggests that the core of full length PrPSc is a 4-rung β-solenoid, and that individual PrPSc subunits stack to form amyloid fibers. We recently used limited proteolysis to map the β-strands and connecting loops that make up the PrPSc solenoid. Using high resolution SDS-PAGE followed by epitope analysis, and mass spectrometry, we identified positions ~116/118, 133-134, 141, 152-153, 162, 169 and 179 (murine numbering) as Proteinase K (PK) cleavage sites in PrPSc. Such sites likely define loops and/or borders of β-strands, helping us to predict the threading of the β-solenoid. We have now extended this approach to recombinant PrPSc (recPrPSc). The term recPrPSc refers to bona fide recombinant prions prepared by PMCA, exhibiting infectivity with attack rates of ~100%. Limited proteolysis of mouse and bank vole recPrPSc species yielded N-terminally truncated PK-resistant fragments similar to those seen in brain-derived PrPSc, albeit with varying relative yields. Along with these fragments, doubly N- and C-terminally truncated fragments, in particular ~89/97-152, were detected in some recPrPSc preparations; similar fragments are characteristic of atypical strains of brain-derived PrPSc. Our results suggest a shared architecture of recPrPSc and brain PrPSc prions. The observed differences, in particular the distinct yields of specific PK-resistant fragments, are likely due to differences in threading which result in the specific biochemical characteristics of recPrPSc. Furthermore, recombinant PrPSc offers exciting opportunities for structural studies unachievable with brain-derived PrPSc.

Pr-magnetism in the quasi-skutterudite compound PrFe2Al8.

Science.gov (United States)

Nair, Harikrishnan S; Ogunbunmi, Michael O; Kumar, C M N; Adroja, D T; Manuel, P; Fortes, D; Taylor, J; Strydom, A M

2017-08-31

The intermetallic compound PrFe 2 Al 8 that possesses a three-dimensional network structure of Al polyhedra centered at the transition metal element Fe and the rare earth Pr is investigated through neutron powder diffraction and inelastic neutron scattering in order to elucidate the magnetic ground state of Pr and Fe and the crystal field effects of Pr. Our neutron diffraction study confirms long-range magnetic order of Pr below [Formula: see text] K in this compound. Subsequent magnetic structure estimation reveals a magnetic propagation vector [Formula: see text] with a magnetic moment value of [Formula: see text]/Pr along the orthorhombic c-axis and evidence the lack of ordering in the Fe sublattice. The inelastic neutron scattering study reveals one crystalline electric field excitation near 19 meV at 5 K in PrFe 2 Al 8 . The energy-integrated intensity of the 19 meV excitation as a function of [Formula: see text] follows the square of the magnetic form factor of [Formula: see text] thereby confirming that the inelastic excitation belongs to the Pr sublattice. The second sum rule applied to the dynamic structure factor indicates only 1.6(2) [Formula: see text] evolving at the 19 meV peak compared to the 3.58 [Formula: see text] for free [Formula: see text], indicating that the crystal field ground state is magnetic and the missing moment is associated with the resolution limited quasi-elastic line. The magnetic order occurring in Pr in PrFe 2 Al 8 is counter-intuitive to the symmetry-allowed crystal field level scheme, hence, is suggestive of exchange-mediated mechanisms of ordering stemming from the magnetic ground state of the crystal field levels.

Successful "First Light" for VLT High-Resolution Spectrograph

Science.gov (United States)

1999-10-01

control system, cf. ESO PR Photos 44/98 , were made in the laboratories of the ESO Headquarters in Garching (Germany) before it was fully dismounted and shipped (some parts by air, others by ship) to the ESO Paranal Observatory, 130 km south of Antofagasta (Chile). Here, the different pieces of UVES (with a total weight of 8 tons) were carefully reassembled on the Nasmyth platform of KUEYEN and made ready for real observations (see ESO PR Photos 36p-t/99 ). UVES is a complex two-channel spectrograph that has been built around two giant optical (echelle diffraction) gratings, each ruled on a 84 cm x 21 cm x 12 cm block of the ceramic material Zerodur (the same that is used for the VLT 8.2-m main mirrors) and weighing more than 60 kg. These echelle gratings finely disperse the light from celestial objects collected by the telescope into its constituent wavelengths (colours). UVES' resolving power (an optical term that indicates the ratio between a given wavelength and the smallest wavelength difference between two spectral lines that are clearly separated by the spectrograph) may reach 110,000, a very high value for an astronomical instrument of such a large size. This means for instance that even comparatively small changes in radial velocity (a few km/sec only) can be accurately measured and also that it is possible to detect the faint spectral signatures of very rare elements in celestial objects. One UVES channel is optimized for the ultraviolet and blue, the other for visual and red light. The spectra are digitally recorded by two highly efficient CCD detectors for subsequent analysis and astrophysical interpretation. By optimizing the transmission of the various optical components in its two channels, UVES has a very high efficiency all the way from the UV (wavelength about 300 nm) to the near-infrared (1000 nm or 1 µm). This guarantees that only a minimum of the precious light that is collected by KUEYEN is lost and that detailed spectra can be obtained of even

State diagram of Pr-Bi system

International Nuclear Information System (INIS)

Abulkhaev, V.L.; Ganiev, I.N.

1994-01-01

By means of thermal differential analysis, X-ray and microstructural analysis the state diagram of Pr-Bi system was studied. Following intermetallic compounds were defined in the system: Pr 2 Bi, Pr 5 Bi 3 , Pr 4 Bi 3 , Pr Bi, PrBi 2 , Pr 2 Bi, Pr 5 Bi 3 , Pr 4 Bi 3 and PrBi 2 . The data analysis on Ln-Bi diagram allowed to determine the regularity of change of properties of intermetallic compounds in the line of rare earth elements of cerium subgroup.

Prion protein (PrP) gene-knockout cell lines: insight into functions of the PrP

Science.gov (United States)

Sakudo, Akikazu; Onodera, Takashi

2015-01-01

Elucidation of prion protein (PrP) functions is crucial to fully understand prion diseases. A major approach to studying PrP functions is the use of PrP gene-knockout (Prnp−/−) mice. So far, six types of Prnp−/− mice have been generated, demonstrating the promiscuous functions of PrP. Recently, other PrP family members, such as Doppel and Shadoo, have been found. However, information obtained from comparative studies of structural and functional analyses of these PrP family proteins do not fully reveal PrP functions. Recently, varieties of Prnp−/− cell lines established from Prnp−/− mice have contributed to the analysis of PrP functions. In this mini-review, we focus on Prnp−/− cell lines and summarize currently available Prnp−/− cell lines and their characterizations. In addition, we introduce the recent advances in the methodology of cell line generation with knockout or knockdown of the PrP gene. We also discuss how these cell lines have provided valuable insights into PrP functions and show future perspectives. PMID:25642423

BANYAN. IX. The Initial Mass Function and Planetary-mass Object Space Density of the TW HYA Association

Science.gov (United States)

Gagné, Jonathan; Faherty, Jacqueline K.; Mamajek, Eric E.; Malo, Lison; Doyon, René; Filippazzo, Joseph C.; Weinberger, Alycia J.; Donaldson, Jessica K.; Lépine, Sébastien; Lafrenière, David; Artigau, Étienne; Burgasser, Adam J.; Looper, Dagny; Boucher, Anne; Beletsky, Yuri; Camnasio, Sara; Brunette, Charles; Arboit, Geneviève

2017-02-01

A determination of the initial mass function (IMF) of the current, incomplete census of the 10 Myr-old TW Hya association (TWA) is presented. This census is built from a literature compilation supplemented with new spectra and 17 new radial velocities from ongoing membership surveys, as well as a reanalysis of Hipparcos data that confirmed HR 4334 (A2 Vn) as a member. Although the dominant uncertainty in the IMF remains census incompleteness, a detailed statistical treatment is carried out to make the IMF determination independent of binning while accounting for small number statistics. The currently known high-likelihood members are fitted by a log-normal distribution with a central mass of {0.21}-0.06+0.11 M ⊙ and a characteristic width of {0.8}-0.1+0.2 dex in the 12 M Jup-2 M ⊙ range, whereas a Salpeter power law with α ={2.2}-0.5+1.1 best describes the IMF slope in the 0.1-2 M ⊙ range. This characteristic width is higher than other young associations, which may be due to incompleteness in the current census of low-mass TWA stars. A tentative overpopulation of isolated planetary-mass members similar to 2MASS J11472421-2040204 and 2MASS J11193254-1137466 is identified: this indicates that there might be as many as {10}-5+13 similar members of TWA with hot-start model-dependent masses estimated at ˜5-7 M Jup, most of which would be too faint to be detected in 2MASS. Our new radial velocity measurements corroborate the membership of 2MASS J11472421-2040204, and secure TWA 28 (M8.5 γ), TWA 29 (M9.5 γ), and TWA 33 (M4.5 e) as members. The discovery of 2MASS J09553336-0208403, a young L7-type interloper unrelated to TWA, is also presented.

Prion protein (PrP) gene-knockout cell lines: insight into functions of the PrP

OpenAIRE

Sakudo, Akikazu; Onodera, Takashi

2015-01-01

Elucidation of prion protein (PrP) functions is crucial to fully understand prion diseases. A major approach to studying PrP functions is the use of PrP gene-knockout (Prnp ?/?) mice. So far, six types of Prnp ?/? mice have been generated, demonstrating the promiscuous functions of PrP. Recently, other PrP family members, such as Doppel and Shadoo, have been found. However, information obtained from comparative studies of structural and functional analyses of these PrP family proteins do not ...

Revisiting progesterone receptor (PR) actions in breast cancer: Insights into PR repressive functions.

Science.gov (United States)

Proietti, Cecilia J; Cenciarini, Mauro E; Elizalde, Patricia V

2018-05-01

Progesterone receptor (PR) is a master regulator in female reproductive tissues that controls developmental processes and proliferation and differentiation during the reproductive cycle and pregnancy. PR also plays a role in progression of endocrine-dependent breast cancer. As a member of the nuclear receptor family of ligand-dependent transcription factors, the main action of PR is to regulate networks of target gene expression in response to binding its cognate steroid hormone, progesterone. Liganded-PR transcriptional activation has been thoroughly studied and associated mechanisms have been described while progesterone-mediated repression has remained less explored. The present work summarizes recent advances in the understanding of how PR-mediated repression is accomplished in breast cancer cells and highlights the significance of fully understanding the determinants of context-dependent PR action. Copyright © 2018 Elsevier Inc. All rights reserved.

Astronomer's new guide to the galaxy: largest map of cold dust revealed

Science.gov (United States)

2009-07-01

Astronomers have unveiled an unprecedented new atlas of the inner regions of the Milky Way, our home galaxy, peppered with thousands of previously undiscovered dense knots of cold cosmic dust -- the potential birthplaces of new stars. Made using observations from the APEX telescope in Chile, this survey is the largest map of cold dust so far, and will prove an invaluable map for observations made with the forthcoming ALMA telescope, as well as the recently launched ESA Herschel space telescope. ESO PR Photo 24a/09 View of the Galactic Plane from the ATLASGAL survey (annotated and in five sections) ESO PR Photo 24b/09 View of the Galactic Plane from the ATLASGAL survey (annotated) ESO PR Photo 24c/09 View of the Galactic Plane from the ATLASGAL survey (in five sections) ESO PR Photo 24d/09 View of the Galactic Plane from the ATLASGAL survey ESO PR Photo 24e/09 The Galactic Centre and Sagittarius B2 ESO PR Photo 24f/09 The NGC 6357 and NGC 6334 nebulae ESO PR Photo 24g/09 The RCW120 nebula ESO PR Video 24a/09 Annotated pan as seen by the ATLASGAL survey This new guide for astronomers, known as the APEX Telescope Large Area Survey of the Galaxy (ATLASGAL) shows the Milky Way in submillimetre-wavelength light (between infrared light and radio waves [1]). Images of the cosmos at these wavelengths are vital for studying the birthplaces of new stars and the structure of the crowded galactic core. "ATLASGAL gives us a new look at the Milky Way. Not only will it help us investigate how massive stars form, but it will also give us an overview of the larger-scale structure of our galaxy", said Frederic Schuller from the Max Planck Institute for Radio Astronomy, leader of the ATLASGAL team. The area of the new submillimetre map is approximately 95 square degrees, covering a very long and narrow strip along the galactic plane two degrees wide (four times the width of the full Moon) and over 40 degrees long. The 16 000 pixel-long map was made with the LABOCA submillimetre

Phase diagram of Pr-P system

International Nuclear Information System (INIS)

Mironov, K.E.

1981-01-01

An area of the Pr-P system, adjoining to the Pr ordinate, is plotted up by the DTA method. Presence of P solid solution in Pr is established. Data on thermal stability of PrP, PrP 2 , PrP 5 and PrP 7 are generalized. The diagram of phase transformations in Pr-P system is plotted up proceeding from the whole complex of the data, presented. A supposition is made on a possible formation of solid solutions between the highest polyphosphide and phosphorus [ru

SINFONI Opens with Upbeat Chords

Science.gov (United States)

2004-08-01

Dutch Institutes and ESO who have worked on the development of SINFONI for nearly 7 years. The work on SINFONI at Paranal included successful commissioning in June 2004 of the Adaptive Optics Module built by ESO, during which exceptional test images were obtained of the main-belt asteroid (22) Kalliope and its moon. Moreover, the ability was demonstrated to correct the atmospheric turbulence by means of even very faint "guide" objects (magnitude 17.5), crucial for the observation of astronomical objects in many parts of the sky. SPIFFI - SPectrometer for Infrared Faint Field Imaging - was developed at the Max Planck Institute for Extraterrestrische Physik (MPE) in Garching (Germany), in a collaboration with the Nederlandse Onderzoekschool Voor Astronomie (NOVA) in Leiden and the Netherlands Foundation for Research in Astronomy (ASTRON), and ESO. PR Photo 24a/04: SINFONI Adaptive Optics Module at VLT Yepun (June 2004) PR Photo 24b/04: SINFONI at VLT Yepun, now fully assembled (July 2004) PR Photo 24c/04: "First Light" image from the SINFONI Adaptive Optics Module PR Photo 24d/04: AO-corrected Image of a 17.5-magnitude Star PR Photo 24e/04: SINFONI undergoing Balancing and Flexure Tests at VLT Yepun PR Photo 24f/04: SINFONI "First Light" Spectrum of HD 130163 PR Photo 24g/04: Members of the SINFONI Adaptive Optics Module Commissioning Team PR Photo 24h/04: Members of the SPIFFI Commissioning Team PR Photo 24i/04: The Principle of Integral Field Spectroscopy (IFS) PR Photo 24j/04: The Orbital Motion of Linus around (22) Kalliope PR Photo 24k/04: SINFONI Observations of the Galactic Centre Region PR Photo 24l/04: SINFONI Observations of the Circinus Galaxy PR Photo 24m/04: SINFONI Observations of the AGN Galaxy NGC 7469 PR Photo 24n/04: SINFONI Observations of NGC 6240 PR Photo 24o/04: SINFONI Observations of the Young Starforming Galaxies BX 404/405 PR Video Clip 07/04: The Orbital Motion of Linus around (22) Kalliope SINFONI: A powerful and complex instrument ESO PR Photo

Gender Systematics in Telescope Time Allocation at ESO

Science.gov (United States)

Patat, F.

2016-09-01

The results of a comprehensive statistical analysis of gender systematics in the time allocation process at ESO are presented. The sample on which the study is based includes more than 13 000 Normal and Short proposals, submitted by about 3000 principal investigators (PI) over eight years. The genders of PIs, and of the panel members of the Observing Programmes Committee (OPC), were used, together with their career level, to analyse the grade distributions and the proposal success rates. Proposals submitted by female PIs show a significantly lower probability of being allocated time. The proposal success rates (defined as number of top ranked runs over requested runs) are 16.0 ± 0.6% and 22.0 ± 0.4% for females and males, respectively. To a significant extent the disparity is related to different input distributions in terms of career level. The seniority of male PIs is significantly higher than that of female PIs, with only 34% of the female PIs being professionally employed astronomers (compared to 53% for male PIs). A small, but statistically significant, gender-dependent behaviour is measured for the OPC referees: both genders show the same systematics, but they are larger for males than females. The PI female/male fraction is very close to 30/70; although far from parity, the fraction is higher than that observed, for instance, among IAU membership.

With the VLT Interferometer towards Sharper Vision

Science.gov (United States)

2000-05-01

The Nova-ESO VLTI Expertise Centre Opens in Leiden (The Netherlands) European science and technology will gain further strength when the new, front-line Nova-ESO VLTI Expertise Centre (NEVEC) opens in Leiden (The Netherlands) this week. It is a joint venture of the Netherlands Research School for Astronomy (NOVA) (itself a collaboration between the Universities of Amsterdam, Groningen, Leiden, and Utrecht) and the European Southern Observatory (ESO). It is concerned with the Very Large Telescope Interferometer (VLTI). The Inauguration of the new Centre will take place on Friday, May 26, 2000, at the Gorlaeus Laboratory (Lecture Hall no. 1), Einsteinweg 55 2333 CC Leiden; the programme is available on the web. Media representatives who would like to participate in this event and who want further details should contact the Nova Information Centre (e-mail: jacques@astro.uva.nl; Tel: +31-20-5257480 or +31-6-246 525 46). The inaugural ceremony is preceded by a scientific workshop on ground and space-based optical interferometry. NEVEC: A Technology Centre of Excellence As a joint project of NOVA and ESO, NEVEC will develop in the coming years the expertise to exploit the unique interferometric possibilities of the Very Large Telescope (VLT) - now being built on Paranal mountain in Chile. Its primary goals are the * development of instrument modeling, data reduction and calibration techniques for the VLTI; * accumulation of expertise relevant for second-generation VLTI instruments; and * education in the use of the VLTI and related matters. NEVEC will develop optical equipment, simulations and software to enable interferometry with VLT [1]. The new Center provides a strong impulse to Dutch participation in the VLTI. With direct involvement in this R&D work, the scientists at NOVA will be in the front row to do observations with this unique research facility, bound to produce top-level research and many exciting new discoveries. The ESO VLTI at Paranal ESO PR Photo 14a/00

Cu4Pr6(MoO4)11-Pr2(MoO4)3 system

International Nuclear Information System (INIS)

Arzumanyan, G.A.

1982-01-01

Existence boundaries and Dalton compositions (CuPr(MoO 4 ) 2 , CuPr 3 (MoO 4 ) 5 ) of solid solutions that in the mojority are of shcheelite dsitored structure have been determined in the Cu 4 Pr 6 (MoO 4 ) 11 -Pr 2 (MoO 4 ) 3 system. It has been revealed that regions of homogeneity near the CuPr(MoO 4 ) 2 composition have a horseshoeshaped profile

Charting the Giants

Science.gov (United States)

2004-06-01

Largest Census Of X-Ray Galaxy Clusters Provides New Constraints on Dark Matter [1] Clusters of galaxies Clusters of galaxies are very large building blocks of the Universe. These gigantic structures contain hundreds to thousands of galaxies and, less visible but equally interesting, an additional amount of "dark matter" whose origin still defies the astronomers, with a total mass of thousands of millions of millions times the mass of our Sun. The comparatively nearby Coma cluster, for example, contains thousands of galaxies and measures more than 20 million light-years across. Another well-known example is the Virgo cluster at a distance of about 50 million light-years, and still stretching over an angle of more than 10 degrees in the sky! Clusters of galaxies form in the densest regions of the Universe. As such, they perfectly trace the backbone of the large-scale structures in the Universe, in the same way that lighthouses trace a coastline. Studies of clusters of galaxies therefore tell us about the structure of the enormous space in which we live. The REFLEX survey ESO PR Photo 18a/04 ESO PR Photo 18a/04 Galaxy Cluster RXCJ 1206.2-0848 (Visible and X-ray) [Preview - JPEG: 400 x 478 pix - 70k] [Normal - JPEG: 800 x 956 pix - 1.2Mk] Caption: PR Photo 18a shows the very massive distant cluster of galaxies RXCJ1206.2-0848, newly discovered during the REFLEX project, and located at a redshift of z = 0.44 [3]. The contours indicate the X-ray surface brightness distribution. Most of the yellowish galaxies are cluster members. A gravitationally lensed galaxy with a distorted, very elongated image is seen, just right of the centre. The image was obtained with the EFOSC multi-mode instrument on the ESO 3.6-m telescope at the La Silla Observatory (Chile). ESO PR Photo 18b/04 ESO PR Photo 18b/04 Galaxy cluster RXCJ1131.9-1955 [Preview - JPEG: 400 x 477 pix - 40k] [Normal - JPEG: 800 x 953 pix - 912k] [FullRes - JPEG: 2251 x 2681 pix - 7.7Mk] Caption: PR Photo 18b displays

The Gaia-ESO Survey: dynamics of ionized and neutral gas in the Lagoon nebula (M 8)

Science.gov (United States)

Damiani, F.; Bonito, R.; Prisinzano, L.; Zwitter, T.; Bayo, A.; Kalari, V.; Jiménez-Esteban, F. M.; Costado, M. T.; Jofré, P.; Randich, S.; Flaccomio, E.; Lanzafame, A. C.; Lardo, C.; Morbidelli, L.; Zaggia, S.

2017-08-01

Aims: We present a spectroscopic study of the dynamics of the ionized and neutral gas throughout the Lagoon nebula (M 8), using VLT-FLAMES data from the Gaia-ESO Survey. The new data permit exploration of the physical connections between the nebular gas and the stellar population of the associated star cluster NGC 6530. Methods: We characterized through spectral fitting emission lines of Hα, [N II] and [S II] doublets, [O III], and absorption lines of sodium D doublet, using data from the FLAMES-Giraffe and UVES spectrographs, on more than 1000 sightlines toward the entire face of the Lagoon nebula. Gas temperatures are derived from line-width comparisons, densities from the [S II] doublet ratio, and ionization parameter from Hα/[N II] ratio. Although doubly-peaked emission profiles are rarely found, line asymmetries often imply multiple velocity components along the same line of sight. This is especially true for the sodium absorption, and for the [O III] lines. Results: Spatial maps for density and ionization are derived, and compared to other known properties of the nebula and of its massive stars 9 Sgr, Herschel 36 and HD 165052 which are confirmed to provide most of the ionizing flux. The detailed velocity fields across the nebula show several expanding shells, related to the cluster NGC 6530, the O stars 9 Sgr and Herschel 36, and the massive protostar M 8East-IR. The origins of kinematical expansion and ionization of the NGC 6530 shell appear to be different. We are able to put constrains on the line-of-sight (relative or absolute) distances between some of these objects and the molecular cloud. The data show that the large obscuring band running through the middle of the nebula is being compressed by both sides, which might explain its enhanced density. We also find an unexplained large-scale velocity gradient across the entire nebula. At larger distances, the transition from ionized to neutral gas is studied using the sodium lines. Based on observations

VLT Data Flow System Begins Operation

Science.gov (United States)

1999-06-01

Building a Terabyte Archive at the ESO Headquarters The ESO Very Large Telescope (VLT) is the sum of many sophisticated parts. The site at Cerro Paranal in the dry Atacama desert in Northern Chile is one of the best locations for astronomical observations from the surface of the Earth. Each of the four 8.2-m telescopes is a technological marvel with self-adjusting optics placed in a gigantic mechanical structure of the utmost precision, continuously controlled by advanced soft- and hardware. A multitude of extremely complex instruments with sensitive detectors capture the faint light from distant objects in the Universe and record the digital data fast and efficiently as images and spectra, with a minimum of induced noise. And now the next crucial link in this chain is in place. A few nights ago, following an extended test period, the VLT Data Flow System began providing the astronomers with a steady stream of high-quality, calibrated image and spectral data, ready to be interpreted. The VLT project has entered into a new phase with a larger degree of automation. Indeed, the first 8.2-m Unit Telescope, ANTU, with the FORS1 and ISAAC instruments, has now become a true astronomy machine . A smooth flow of data through the entire system ESO PR Photo 25a/99 ESO PR Photo 25a/99 [Preview - JPEG: 400 x 292 pix - 104k] [Normal - JPEG: 800 x 584 pix - 264k] [High-Res - JPEG: 3000 x 2189 pix - 1.5M] Caption to ESO PR Photo 25a/99 : Simplified flow diagramme for the VLT Data Flow System . It is a closed-loop software system which incorporates various subsystems that track the flow of data all the way from the submission of proposals to storage of the acquired data in the VLT Science Archive Facility. The DFS main components are: Program Handling, Observation Handling, Telescope Control System, Science Archive, Pipeline and Quality Control. Arrows indicate lines of feedback. Already from the start of this project more than ten years ago, the ESO Very Large Telescope was

Photon cascade luminescence from Pr3+ ions in LiPrP4O12 polyphosphate

International Nuclear Information System (INIS)

Shalapska, T; Stryganyuk, G; Romanyshyn, Yu; Demchenko, P; Voloshinovskii, A; Trots, D; Gektin, A; Dorenbos, P

2010-01-01

The spectral-kinetic properties of luminescence from LiY 1-x Pr x P 4 O 12 (x = 1, 0.1) phosphors are studied in the 10-300 K temperature range upon excitation within the UV-VUV spectral range. The luminescence observed for LiPrP 4 O 12 at low temperatures is attributed to both intra-configurational 4f 2 → 4f 2 and inter-configurational 4f5d → 4f 2 radiative transitions of Pr 3+ . The temperature dependence of emission and the decay kinetics of Pr 3+ luminescence from LiY 1-x Pr x P 4 O 12 (x = 1, 0.1) phosphors are explained by temperature stimulated transitions from the 1 S 0 to the Pr 3+ 4f5d state. At low temperatures, the energy potential barrier between the 1 S 0 and 4f5d states is 0.014 eV for LiPrP 4 O 12 . The spectral overlap of the 1 S 0 and 4f5d states of Pr 3+ in LiY 0.9 Pr 0.1 P 4 O 12 determines the luminescence properties in the entire temperature range studied.

The Growing-up of a Star

Science.gov (United States)

2008-01-01

Using ESO's Very Large Telescope Interferometer, astronomers have probed the inner parts of the disc of material surrounding a young stellar object, witnessing how it gains its mass before becoming an adult. ESO PR Photo 03/08 ESO PR Photo 03a/08 The disc around MWC 147 (Artist's Impression) The astronomers had a close look at the object known as MWC 147, lying about 2,600 light years away towards the constellation of Monoceros ('the Unicorn'). MWC 147 belongs to the family of Herbig Ae/Be objects. These have a few times the mass of our Sun and are still forming, increasing in mass by swallowing material present in a surrounding disc. MWC 147 is less than half a million years old. If one associated the middle-aged, 4.6 billion year old Sun with a person in his early forties, MWC 147 would be a 1-day-old baby [1]. The morphology of the inner environment of these young stars is however a matter of debate and knowledge of it is important to better understand how stars and their cortège of planets form. The astronomers Stefan Kraus, Thomas Preibisch, and Keiichi Ohnaka have used the four 8.2-m Unit Telescopes of ESO's Very Large Telescope to this purpose, combining the light from two or three telescopes with the MIDI and AMBER instruments. "With our VLTI/MIDI and VLTI/AMBER observations of MWC147, we combine, for the first time, near- and mid-infrared interferometric observations of a Herbig Ae/Be star, providing a measurement of the disc size over a wide wavelength range [2]," said Stefan Kraus, lead-author of the paper reporting the results. "Different wavelength regimes trace different temperatures, allowing us to probe the disc's geometry on the smaller scale, but also to constrain how the temperature changes with the distance from the star." The near-infrared observations probe hot material with temperatures of up to a few thousand degrees in the innermost disc regions, while the mid-infrared observations trace cooler dust further out in the disc. The

New Light on Dark Energy

Science.gov (United States)

2008-01-01

Using ESO's Very Large Telescope Interferometer, astronomers have probed the inner parts of the disc of material surrounding a young stellar object, witnessing how it gains its mass before becoming an adult. ESO PR Photo 03/08 ESO PR Photo 03a/08 The disc around MWC 147 (Artist's Impression) The astronomers had a close look at the object known as MWC 147, lying about 2,600 light years away towards the constellation of Monoceros ('the Unicorn'). MWC 147 belongs to the family of Herbig Ae/Be objects. These have a few times the mass of our Sun and are still forming, increasing in mass by swallowing material present in a surrounding disc. MWC 147 is less than half a million years old. If one associated the middle-aged, 4.6 billion year old Sun with a person in his early forties, MWC 147 would be a 1-day-old baby [1]. The morphology of the inner environment of these young stars is however a matter of debate and knowledge of it is important to better understand how stars and their cortège of planets form. The astronomers Stefan Kraus, Thomas Preibisch, and Keiichi Ohnaka have used the four 8.2-m Unit Telescopes of ESO's Very Large Telescope to this purpose, combining the light from two or three telescopes with the MIDI and AMBER instruments. "With our VLTI/MIDI and VLTI/AMBER observations of MWC147, we combine, for the first time, near- and mid-infrared interferometric observations of a Herbig Ae/Be star, providing a measurement of the disc size over a wide wavelength range [2]," said Stefan Kraus, lead-author of the paper reporting the results. "Different wavelength regimes trace different temperatures, allowing us to probe the disc's geometry on the smaller scale, but also to constrain how the temperature changes with the distance from the star." The near-infrared observations probe hot material with temperatures of up to a few thousand degrees in the innermost disc regions, while the mid-infrared observations trace cooler dust further out in the disc. The

Black Hole in Search of a Home

Science.gov (United States)

2005-09-01

Astronomers Discover Bright Quasar Without Massive Host Galaxy An international team of astronomers [1] used two of the most powerful astronomical facilities available, the ESO Very Large Telescope (VLT) at Cerro Paranal and the Hubble Space Telescope (HST), to conduct a detailed study of 20 low redshift quasars. For 19 of them, they found, as expected, that these super massive black holes are surrounded by a host galaxy. But when they studied the bright quasar HE0450-2958, located some 5 billion light-years away, they couldn't find evidence for an encircling galaxy. This, the astronomers suggest, may indicate a rare case of collision between a seemingly normal spiral galaxy and a much more exotic object harbouring a very massive black hole. With masses up to hundreds of millions that of the Sun, "super massive" black holes are the most tantalizing objects known. Hiding in the centre of most large galaxies, including our own Milky Way (see ESO PR 26/03), they sometimes manifest themselves by devouring matter they engulf from their surroundings. Shining up to the largest distances, they are then called "quasars" or "QSOs" (for "quasi-stellar objects"), as they had initially been confused with stars. Decades of observations of quasars have suggested that they are always associated with massive host galaxies. However, observing the host galaxy of a quasar is a challenging work, because the quasar is radiating so energetically that its host galaxy is hard to detect in the flare. ESO PR Photo 28a/05 ESO PR Photo 28a/05 Two Quasars with their Host Galaxy [Preview - JPEG: 400 x 760 pix - 82k] [Normal - JPEG: 800 x 1520 pix - 395k] [Full Res - JPEG: 1722 x 3271 pix - 4.0M] Caption: ESO PR Photo 28a/05 shows two examples of quasars from the sample studied by the astronomers, where the host galaxy is obvious. In each case, the quasar is the bright central spot. The host of HE1239-2426 (left), a z=0.082 quasar, displays large spiral arms, while the host of HE1503+0228 (right

Feeding the Monster

Science.gov (United States)

2005-10-01

Near-infrared images of the active galaxy NGC 1097, obtained with the NACO adaptive optics instrument on ESO's Very Large Telescope, disclose with unprecedented detail a complex central network of filamentary structure spiralling down to the centre of the galaxy. These observations provide astronomers with new insights on how super-massive black holes lurking inside galaxies get fed. "This is possibly the first time that a detailed view of the channelling process of matter, from the main part of the galaxy down to the very end in the nucleus is released," says Almudena Prieto (Max-Planck Institute, Heidelberg, Germany), lead author of the paper describing these results. Located at a distance of about 45 million light-years in the southern constellation Fornax (the Furnace), NGC 1097 is a relatively bright, barred spiral galaxy seen face-on. At magnitude 9.5, and thus just 25 times fainter than the faintest object that can be seen with the unaided eye, it appears in small telescopes as a bright, circular disc. NGC 1097 is a very moderate example of an Active Galactic Nucleus (AGN), whose emission is thought to arise from matter (gas and stars) falling into oblivion in a central black hole. However, NGC 1097 possesses a comparatively faint nucleus only, and the black hole in its centre must be on a very strict "diet": only a small amount of gas and stars is apparently being swallowed by the black hole at any given moment. Astronomers have been trying to understand for a long time how the matter is "gulped" down towards the black hole. Watching directly the feeding process requires very high spatial resolution at the centre of galaxies. This can be achieved by means of interferometry as was done with the VLTI MIDI instrument on the central parts of another AGN, NGC 1068 (see ESO PR 17/03), or with adaptive optics [1]. Thus, astronomers [2] obtained images of NGC 1097 with the adaptive optics NACO instrument attached to Yepun, the fourth Unit Telescope of ESO's VLT

A 3000 TNOs Survey Project at ESO La Silla

Science.gov (United States)

Boehnhardt, H.; Hainaut, O.

We propose a wide-shallow TNO search to be done with the Wide Field Imager (WFI) instrument at the 2.2m MPG/ESO telescope in La Silla/Chile. The WFI is a half-deg camera equipped with an 8kx8k CCD (0.24 arcsec/pixel). The telescope can support excellent seeing quality down to 0.5arcsec FWHM. A TNO search pilot project was run with the 2.2m+WFI in 1999: images with just 1.6sdeg sky coverage and typically 24mag limiting brightness revealed 6 new TNOs when processed with our new automatic detection program MOVIE. The project is now continued on a somewhat larger scale in order to find more TNOs and to fine-tune the operational environment for a full automatic on-line detection, astrometry and photometry of the objects at the telescope. The future goal is to perform - with the 2.2m+WFI and in an international colaboration - an even larger TNO survey over a major part of the sky (typically 2000sdeg in and out of Ecliptic) down to 24mag. Follow-up astrometry and photometry of the expected more than 3000 discovered objects will secure their orbital and physical characterisation for synoptic dynamical and taxonomic studies of the Transneptunian population.

PrEP (Pre-Exposure Prophylaxis) 101

Science.gov (United States)

... than 70%. Your risk of getting HIV from sex can be even lower if you combine PrEP with condoms and other prevention methods. Download PrEP 101 Consumer Info Sheet Vital Signs Fact Sheet on Daily Pill Can Prevent HIV (PrEP) Expand All Collapse All Video Introductions to PrEP What is PrEP? A Brief ...

PrP Conformational Transitions Alter Species Preference of a PrP-specific antibody

NARCIS (Netherlands)

Zou, W.Q.; Langeveld, J.P.M.; Xiao, X.; Chen, S.; McGeer, P.L.; Yuan, J.; Payne, M.C.; Kang, H.E.; McGeehan, J.M.; Sy, M.S.; Greenspan, N.S.; Kaplan, D.; Wang, G.X.; Parchi, P.; Hoover, E.A.; Kneale, G.; Telling, G.; Surewicz, W.; Kong, Q.; Guo, J.

2010-01-01

The epitope of the 3F4 antibody most commonly used in human prion disease diagnosis is believed to consist of residues Met-Lys-His-Met (MKHM) corresponding to human PrP-(109–112). This assumption is based mainly on the observation that 3F4 reacts with human and hamster PrP but not with PrP from

The Milky Way above La Silla

Science.gov (United States)

2004-09-01

Anybody who visits a high-altitude astronomical observatory at this time of the year will be impressed by the beauty of the Milky Way band that stretches across the sky. Compared to the poor views from cities and other human conglomerations, the dark and bright nebulae come into view together with an astonishing palette of clear stellar colours. This view above the ESO La Silla Observatory in the southernmost part of the Atacama desert was obtained some evenings ago by ESO Software Engineer Nico Housen. Normally stationed at the Paranal Observatory, he seized the opportunity of a visit to ESO's other observatory site to produce this amazing vista of the early evening scenery. To the left is the decommisioned 15-metre dish of the Swedish-ESO Submillimetre Telescope (SEST), and on the right in the background is the dome of the ESO 3.6-metre telescope, at the highest point of the mountain. The southern Milky Way is seen along the right border of the SEST and above the 3.6 metre telescope. There is an upside-down reflection of the sky and the horizon behind the photographer in the highly polished antenna dish of the SEST. Besides the reflection of the horizon (the darker part in the top of the dish) and the Milky Way (which runs as a thin cloud from the bottom of the dish up to the horizon) there is also a yellow area of light to the right. This is the reflection of the city lights of the city of La Serena, about 100 km away and too faint to disturb observations of celestial objects high above La Silla. The 3.6-m telescope began operations in 1976 and was ESO's largest telescope until the advent of the VLT at Paranal. Never endowed with a fancy name like the VLT Unit telescopes, the "3.6-m" houses several state-of-the-art astronomical instruments, including the ultra-precise HARPS facility that is used to hunt for exoplanets, cf. ESO PR 22/04. The SEST was for a long time the only instrument of its kind in the southern hemisphere. With it, ESO gained invaluable

Deepest Wide-Field Colour Image in the Southern Sky

Science.gov (United States)

2003-01-01

LA SILLA CAMERA OBSERVES CHANDRA DEEP FIELD SOUTH ESO PR Photo 02a/03 ESO PR Photo 02a/03 [Preview - JPEG: 400 x 437 pix - 95k] [Normal - JPEG: 800 x 873 pix - 904k] [HiRes - JPEG: 4000 x 4366 pix - 23.1M] Caption : PR Photo 02a/03 shows a three-colour composite image of the Chandra Deep Field South (CDF-S) , obtained with the Wide Field Imager (WFI) camera on the 2.2-m MPG/ESO telescope at the ESO La Silla Observatory (Chile). It was produced by the combination of about 450 images with a total exposure time of nearly 50 hours. The field measures 36 x 34 arcmin 2 ; North is up and East is left. Technical information is available below. The combined efforts of three European teams of astronomers, targeting the same sky field in the southern constellation Fornax (The Oven) have enabled them to construct a very deep, true-colour image - opening an exceptionally clear view towards the distant universe . The image ( PR Photo 02a/03 ) covers an area somewhat larger than the full moon. It displays more than 100,000 galaxies, several thousand stars and hundreds of quasars. It is based on images with a total exposure time of nearly 50 hours, collected under good observing conditions with the Wide Field Imager (WFI) on the MPG/ESO 2.2m telescope at the ESO La Silla Observatory (Chile) - many of them extracted from the ESO Science Data Archive . The position of this southern sky field was chosen by Riccardo Giacconi (Nobel Laureate in Physics 2002) at a time when he was Director General of ESO, together with Piero Rosati (ESO). It was selected as a sky region towards which the NASA Chandra X-ray satellite observatory , launched in July 1999, would be pointed while carrying out a very long exposure (lasting a total of 1 million seconds, or 278 hours) in order to detect the faintest possible X-ray sources. The field is now known as the Chandra Deep Field South (CDF-S) . The new WFI photo of CDF-S does not reach quite as deep as the available images of the "Hubble Deep Fields

PrP expression, PrPSc accumulation and innervation of splenic compartments in sheep experimentally infected with scrapie.

Directory of Open Access Journals (Sweden)

Randi Sørby

Full Text Available BACKGROUND: In prion disease, the peripheral expression of PrP(C is necessary for the transfer of infectivity to the central nervous system. The spleen is involved in neuroinvasion and neural dissemination in prion diseases but the nature of this involvement is not known. The present study undertook the investigation of the spatial relationship between sites of PrP(Sc accumulation, localisation of nerve fibres and PrP(C expression in the tissue compartments of the spleen of scrapie-inoculated and control sheep. METHODOLOGY/PRINCIPAL FINDINGS: Laser microdissection and quantitative PCR were used to determine PrP mRNA levels and results were compared with immunohistochemical protocols to distinguish PrP(C and PrP(Sc in tissue compartments of the spleen. In sheep experimentally infected with scrapie, the major sites of accumulation of PrP(Sc in the spleen, namely the lymphoid nodules and the marginal zone, expressed low levels of PrP mRNA. Double immunohistochemical labelling for PrP(Sc and the pan-nerve fibre marker, PGP, was used to evaluate the density of innervation of splenic tissue compartments and the intimacy of association between PrP(Sc and nerves. Some nerve fibres were observed to accompany blood vessels into the PrP(Sc-laden germinal centres. However, the close association between nerves and PrP(Sc was most apparent in the marginal zone. Other sites of close association were adjacent to the wall of the central artery of PALS and the outer rim of germinal centres. CONCLUSIONS/SIGNIFICANCE: The findings suggest that the degree of PrP(Sc accumulation does not depend on the expression level of PrP(C. Though several splenic compartments may contribute to neuroinvasion, the marginal zone may play a central role in being the compartment with most apparent association between nerves and PrP(Sc.

ASASSN-18gq: Discovery of A Low-Luminosity Transient Towards Very Nearby ( 3.4 Mpc) Galaxy ESO 325- G?011

Science.gov (United States)

Nicholls, B.; Brimacombe, J.; Vallely, P.; Dong, Subo; Stanek, K. Z.; Kochanek, C. S.; Brown, J. S.; Shields, J.; Thompson, T. A.; Shappee, B. J.; Holoien, T. W.-S.; Prieto, J. L.; Bersier, D.; Bose, S.; Chen, Ping; Stritzinger, M.; Holmbo, S.

2018-04-01

During the ongoing All Sky Automated Survey for SuperNovae (ASAS-SN, Shappee et al. 2014), using data from the quadruple 14-cm "Payne-Gaposchkin" telescope in Sutherland, South Africa, and the quadruple 14-cm "Cassius" and "Paczynski" telescopes in Cerro Tololo, Chile, we discovered a new transient source, most likely a supernova, in the low surface brightness galaxy ESO 325- G?011.

Cancer de la próstata

OpenAIRE

Mendoza, Lupi Alejandro; Fundación Valle de Lili; Gutierrez, María Carolina; López Cardona, Arturo

1997-01-01

¿Qué es la próstata?/¿Qué es la hiperplasia benigna de próstata?/El cáncer de próstata/¿Se hereda el cáncer de próstata?/¿Cómo se presenta y hacia donde se disemina el cáncer de próstata?/¿Cómo de descubre el cáncer de próstata?/¿Qué estudia la ultrasonografía transrectal o ecografía a través de recto?/¿Cómo se analizan los niveles de PSA?/¿Cómo se clasifica el cáncer de próstata?¿Cómo se determina la terapia más adecuada para un cáncer de próstata?/¿Cuáles son las opciones de tratamiento par...

Desarrollo de una actividad grupal, basada en el uso de internet, para alumnos de ESO

OpenAIRE

López de Dios, María Victoria

2015-01-01

El presente trabajo Fin de Master, desarrolla el proceso de creación de una metodología didáctica grupal basada en el uso de internet, en concreto una WebQuest, para alumnos de 3º de la ESO, y para la asignatura de Biología y Geología. El tema elegido ha sido "El Chancro del Castaño", y nos hemos basado en un gestor Web de contenidos, denominado Wix.com. Departamento de Bioquímica y Biología Molecular y Fisiología Máster en Profesor de Educación Secundaria Obligatoria y Bachillerato, Fo...

Spectroscopic study of the elusive globular cluster ESO452-SC11 and its surroundings

Science.gov (United States)

Koch, Andreas; Hansen, Camilla Juul; Kunder, Andrea

2017-08-01

Globular clusters (GCs) have long been recognized as being amongst the oldest objects in the Galaxy. As such, they have the potential of playing a pivotal role in deciphering the Milky Way's early history. Here we present the first spectroscopic study of the low-mass system ESO452-SC11 using the AAOmega multifibre spectrograph at medium resolution. Given the stellar sparsity of this object and the high degree of foreground contamination due to its location toward the Galactic bulge, very few details are known for this cluster - there is no consensus, for instance, about its age, metallicity, or its association with the disk or bulge. We identify five member candidates based on common radial velocity, calcium-triplet metallicity, and position within the GC. Using spectral synthesis, the measurement of accurate Fe-abundances from Fe-lines, and abundances of several α-, Fe-peak, and neutron-capture elements (Si, Ca, Ti,Cr, Co, Ni, Sr, and Eu) is carried out, albeit with large uncertainties. We find that two of the five cluster candidates are likely non-members, as they have deviating iron abundances and [α/Fe] ratios. The cluster mean heliocentric velocity is 19 ± 2 km s-1 with a velocity dispersion of 2.8 ± 3.4 km s-1, a low value in line with its sparse nature and low mass. The mean Fe-abundance from spectral fitting is -0.88 ± 0.03 dex, where the spread is driven by observational errors. Furthermore, the α-elements of the GC candidates are marginally lower than expected for the bulge at similar metallicities. As spectra of hundreds of stars were collected in a 2-degree field centered on ESO452-SC11, a detailed abundance study of the surrounding field was also enabled. The majority of the non-members have slightly higher [α/Fe] ratios, in line with the typical nearby bulge population. A subset of the spectra with measured Fe-peak abundance ratios shows a large scatter around solar values, albeit with large uncertainties. Furthermore, our study provides the

New Inspiring Planetarium Show Introduces ALMA to the Public

Science.gov (United States)

2009-03-01

As part of a wide range of education and public outreach activities for the International Year of Astronomy 2009 (IYA2009), ESO, together with the Association of French Language Planetariums (APLF), has produced a 30-minute planetarium show, In Search of our Cosmic Origins. It is centred on the global ground-based astronomical Atacama Large Millimeter/submillimeter Array (ALMA) project and represents a unique chance for planetariums to be associated with the IYA2009. ESO PR Photo 09a/09 Logo of the ALMA Planetarium Show ESO PR Photo 09b/09 Galileo's first observations with a telescope ESO PR Photo 09c/09 The ALMA Observatory ESO PR Photo 09d/09 The Milky Way band ESO PR Video 09a/09 Trailer in English ALMA is the leading telescope for observing the cool Universe -- the relic radiation of the Big Bang, and the molecular gas and dust that constitute the building blocks of stars, planetary systems, galaxies and life itself. It is currently being built in the extremely arid environment of the Chajnantor plateau, at 5000 metres altitude in the Chilean Andes, and will start scientific observations around 2011. ALMA, the largest current astronomical project, is a revolutionary telescope, comprising a state-of-the-art array of 66 giant 12-metre and 7-metre diameter antennas observing at millimetre and submillimetre wavelengths. In Search of our Cosmic Origins highlights the unprecedented window on the Universe that this facility will open for astronomers. "The show gives viewers a fascinating tour of the highest observatory on Earth, and takes them from there out into our Milky Way, and beyond," says Douglas Pierce-Price, the ALMA Public Information Officer at ESO. Edited by world fulldome experts Mirage3D, the emphasis of the new planetarium show is on the incomparable scientific adventure of the ALMA project. A young female astronomer guides the audience through a story that includes unique animations and footage, leading the viewer from the first observations by Galileo

Production of no-carrier-added 139Pr via precursor decay in the proton bombardment of natPr

International Nuclear Information System (INIS)

Steyn, G.F.; Vermeulen, C.; Nortier, F.M.; Szelecsenyi, F.; Kovacs, Z.; Qaim, S.M.

2006-01-01

Excitation functions and production rates are presented for various Pr and Nd radionuclides formed in the bombardment of Pr with protons, from their respective thresholds up to 100 MeV. The indirect production route 141 Pr(p, 3n) 139m Nd → 139 Pr is investigated as an alternative to the direct production route 140 Ce(p, 2n) 139 Pr for producing no-carrier-added 139 Pr of high radionuclidic purity. The simultaneous production of 139 Pr and 140 Nd using Pr as target is investigated. The advantages and disadvantages of both production routes are discussed. Experimental thick-target production rates are presented for selected Pr radionuclides formed in the bombardment of nat Ce with protons at incident energies of 20, 26 and 32 MeV. All the experimental excitation functions obtained in this work are compared with theoretical predictions by means of the geometry-dependent hybrid (GDH) model as implemented in the code ALICE-IPPE. The results of this work are also compared with previous literature experimental data, if available

Erfolgsfaktoren unternehmerischer Krisen-PR

OpenAIRE

Scharr, Florian

2006-01-01

Ob "Peanuts", "Elchtest" oder "Hoechst-Störfall" - bei diesen bekannten Öffentlichkeitskrisen der letzten Jahre rief die mangelhafte Krisen-PR der betroffenen Unternehmen bei Medien und Bevölkerung mehr Empörung hervor als die originären Auslöser und potenzierte so den entstandenen Vertrauensverlust. Auch die sich gerade erst entwickelnde PR-Forschung bietet noch keine konkrete Hilfestellung zur Gestaltung von Krisen-PR. Mit dem bedeutenden Diskurs- und dadurch Realitätsgestaltungsmittel Pres...

Final binary star results from the ESO VLT Lunar occultations program

Energy Technology Data Exchange (ETDEWEB)

Richichi, A. [National Astronomical Research Institute of Thailand, 191 Siriphanich Bldg., Huay Kaew Road, Suthep, Muang, Chiang Mai 50200 (Thailand); Fors, O. [Departament Astronomia i Meteorologia and Institut de Ciències del Cosmos (ICC), Universitat de Barcelona (UB/IEEC), Martí i Franqués 1, E-08028 Barcelona (Spain); Cusano, F. [INAF-Osservatorio Astronomico di Bologna, Via Ranzani 1, I-40127 Bologna (Italy); Ivanov, V. D., E-mail: andrea4work@gmail.com [European Southern Observatory, Ave. Alonso de Cordova 3107, Casilla 19001, Santiago 19 (Chile)

2014-03-01

We report on 13 subarcsecond binaries, detected by means of lunar occultations in the near-infrared at the ESO Very Large Telescope (VLT). They are all first-time detections except for the visual binary HD 158122, which we resolved for the first time in the near-infrared. The primaries have magnitudes in the range K = 4.5-10.0, and companions in the range K = 6.8-11.1. The magnitude differences have a median value of 2.4, with the largest being 4.6. The projected separations are in the range of 4-168 mas, with a median of 13 mas. We discuss and compare our results with the available literature. With this paper, we conclude the mining for binary star detections in the 1226 occultations recorded at the VLT with the ISAAC instrument. We expect that the majority of these binaries may be unresolvable by adaptive optics on current telescopes, and they might be challenging for long-baseline interferometry. However, they constitute an interesting sample for future larger telescopes and for astrometric missions such as GAIA.

Nuclei of dwarf spheroidal galaxies KKs3 and ESO269-66 and their counterparts in our Galaxy

OpenAIRE

Sharina, M. E.; Shimansky, V. V.; Kniazev, A. Y.

2017-01-01

We present the analysis of medium-resolution spectra obtained at the Southern African Large Telescope (SALT) for nuclear globular clusters (GCs) in two dwarf spheroidal galaxies (dSphs). The galaxies have similar star formation histories, but they are situated in completely different environments. ESO269-66 is a close neighbour of the giant S0 NGC5128. KKs3 is one of the few truly isolated dSphs within 10 Mpc. We estimate the helium abundance $Y=0.3$, $\\rm age=12.6\\pm1$ Gyr, $[Fe/H]=-1.5,-1.5...

Salvinorin A analogues PR-37 and PR-38 attenuate compound 48/80-induced itch responses in mice.

Science.gov (United States)

Salaga, M; Polepally, P R; Zielinska, M; Marynowski, M; Fabisiak, A; Murawska, N; Sobczak, K; Sacharczuk, M; Do Rego, J C; Roth, B L; Zjawiony, J K; Fichna, J

2015-09-01

The opioid system plays a crucial role in several physiological processes in the CNS and in the periphery. It has also been shown that selective opioid receptor agonists exert potent inhibitory action on pruritus and pain. In this study we examined whether two analogues of Salvinorin A, PR-37 and PR-38, exhibit antipruritic properties in mice. To examine the antiscratch effect of PR-37 and PR-38 we used a mouse model of compound 48/80-induced pruritus. In order to elucidate the mechanism of action of tested compounds, specific antagonists of opioid and cannabinoid receptors were used. The effect of PR-37 on the CNS was assessed by measuring motor parameters and exploratory behaviours in mice. PR-37 and PR-38, jnjected s.c., significantly reduced the number of compound 48/80-induced scratching behaviours in mice in a dose- and time-dependent manner. PR-38 was also active when orally administered. The antiscratch activity of PR-37 was blocked by the selective κ opioid receptor antagonist, nor-binaltorphimine, and that of PR-38 by the selective μ opioid receptor antagonist, β-funaltrexamine. In conclusion, a novel framework for the development of new antipruritic drugs derived from salvinorin A has been validated. © 2015 The British Pharmacological Society.

RFA-based 589-nm guide star lasers for ESO VLT: a paradigm shift in performance, operational simplicity, reliability, and maintenance

Science.gov (United States)

Friedenauer, Axel; Karpov, Vladimir; Wei, Daoping; Hager, Manfred; Ernstberger, Bernhard; Clements, Wallace R. L.; Kaenders, Wilhelm G.

2012-07-01

Large telescopes equipped with adaptive optics require 20-25W CW 589-nm sources with emission linewidths of ~5 MHz. These Guide Star (GS) lasers should also be highly reliable and simple to operate and maintain for many years at the top of a mountain facility. Under contract from ESO, industrial partners TOPTICA and MPBC are nearing completion of the development of GS lasers for the ESO VLT, with delivery of the first of four units scheduled for December 2012. We report on the design and performance of the fully-engineered Pre-Production Unit (PPU), including system reliability/availability analysis, the successfully-concluded qualification testing, long-term component and system level tests and long-term maintenance and support planning. The chosen approach is based on ESO's patented narrow-band Raman Fiber Amplifier (EFRA) technology. A master oscillator signal from a linearly-polarized TOPTICA 20-mW, 1178-nm CW diode laser, with stabilized emission frequency and controllable linewidth up to a few MHz, is amplified in an MPBC polarization-maintaining (PM) RFA pumped by a high-power 1120-nm PM fiber laser. With efficient stimulated Brillouin scattering suppression, an unprecedented 40W of narrow-band RFA output has been obtained. This is then mode-matched into a resonant-cavity doubler with a free-spectral-range matching the sodium D2a to D2b separation, allowing simultaneous generation of an additional frequency component (D2b line) to re-pump the sodium atom electronic population. With this technique, the return flux can be increased without having to resort to electro-optical modulators and without the risk of introducing optical wave front distortions. The demonstrated output powers with doubling efficiencies >80% at 589 nm easily exceed the 20W design goal and require less than 700 W of electrical power. In summary, the fiber-based guide star lasers provide excellent beam quality and are modular, turn-key, maintenance-free, reliable, efficient, and ruggedized

A Milestone for the VLT Interferometer

Science.gov (United States)

2000-10-01

Less than one month after "First Light" for the fourth 8.2-m YEPUN telescope ( ESO PR 18/00 ), another special moment occurred at ESO's Paranal Observatory. This time, it was the first truly "underground" event, in the 168-metre long Interferometric Tunnel that has been dug beneath the platform at the top of the mountain. As one staff member remarked on this occasion, it was something like "the first scheduled trip of the Paranal metro"! With the successful integration of the first Delay Line on Monday, September 25th, 2000, ESO has accomplished another important step towards the VLT Interferometer (VLTI). It will be followed by the integration of the second Delay Line by the end of November and the third is scheduled for February 2001; both are now in their final development phase in Europe. "VLTI First Light" is then expected to take place soon thereafter, by means of two small special telescopes ("siderostats"). The combination of the light beams from two of the 8.2-m Unit Telescopes will happen in mid-2001. The VLTI Delay Lines The VLTI Delay Lines form essential parts of this very complicated optical system. They serve to ensure that the light beams from several telescopes arrive in phase at the common interferometric focus. Details about how they function may be found in ESO PR 04/98. In order to achieve the necessary performance, ESO has worked with two Dutch contractors, Fokker Space and TNO-TPD - Netherlands Organization for Applied Scientific Research - Institute of Applied Physics , to arrive at a totally new Delay Line concept. Another Dutch participant in the VLTI project is the Nova-ESO VLTI Expertise Centre (NEVEC) , cf. ESO PR 14/00. The installation at Paranal The last twelve months have been very busy for the integration team, with much preparatory work at the VLTI buildings for the final installation of the Delay Line systems. The assembly of the translation mechanisms for the first two Delay Lines in the tunnel started in mid-2000. This included

Armonización entre proceso de aprendizaje y práctica deportiva en universitarios deportistas de alto nivel

Directory of Open Access Journals (Sweden)

Pedro R. Álvarez Pérez

2012-01-01

Full Text Available Este trabajo se ha centrado en el análisis de las dificultadesque los estudiantes universitarios deportistas de alto nivel encuentran para conciliar su proceso formativo con la práctica deportiva de alta competición. Sin una ayuda adecuada para gestionar la alternancia de esta doble actividad, muchos de estos estudiantes pueden verse abocados a situaciones de estrés, fracaso oabandono de los estudios o del deporte. Por eso, el objetivo de la investigación se orientó al diagnóstico de lascondiciones bajo las cuales se lleva a cabo el proceso de aprendizaje de estos estudiantes deportistas y la evaluación de las necesidades que tienen para compaginar el proceso formativo con la práctica deportiva. Se siguió un método descriptivo y exploratorio, empleándose diferentes estrategias de corte cualitativo: una entrevista en profundidad con los 16 estudiantes deportistas de alto nivel reconocidos por el Consejo Superior de Deportes y matriculados en diversas titulaciones de la Universidad de La Laguna durante el curso 2009-2010 y un grupo de discusión con 8 informantes críticos cuya actividad profesional estaba vinculada a la formación y la práctica deportiva. Después del proceso de análisis de contenido,esencialización y categorización de las proposiciones de respuesta ofrecidas por los participantes, los resultados pusieron de manifiesto que son diversas las variables que condicionan el desarrollo paralelo de estas dos actividades (tiempo, motivación, exigencias formativas, etc.. Del estudio se deriva la necesidad de tener en cuenta la realidad personal de estos estudiantes, introduciendo medidas de apoyo y adaptando la enseñanza a su situación y a sus necesidades específicas para el desarrollo en paralelo de la actividad deportiva y académica.

CONSEIL D'ADMINISTRATION DE LA CAISSE DE PENSIONS - French version only

CERN Multimedia

2003-01-01

Le Conseil d'administration s'est réuni en date du 6 mai 2003. Cette réunion, la cent-seizième, a été consacrée essentiellement à deux présentations, la première par J-P. Matheys, Président du groupe de travail sur la question de l'ESO, qui a fait rapport sur la première réunion du groupe; la seconde par Guy Maurin, Président du Comité de placement, sur la séance tenue le 9 avril. J.-P. Matheys a rappelé que le Conseil d'administration de la Caisse avait été saisi d'une demande de l'ESO portant sur des changements que cette Organisation souhaite apporter aux modalités d'affiliation des membres de son personnel titulaires. Lors de la première réunion du Groupe de travail qui a été spécialement créé pour examiner cette demande, les membres du groupe sont tombés d'accord sur le fait que le groupe devait en priorité veiller à ce que la demande de l'ESO n'ait pas de répercussions financières ou légales pour la Caisse. Le Groupe s'est également rallié à l'opinion du Conseil d'admi...

Práticas cotidianas de acesso às TICs — outro modo de compreender a inclusão digital

Directory of Open Access Journals (Sweden)

Denise Cogo

2015-01-01

Full Text Available El artículo plantea un debate acerca de la inclusión social y digital a partir de la observación de prácticas relacionadas al acceso y uso de las Tecnologías de la Información y la Comunicación (TICs en el cotidiano. Para ello, se desarrolla una reflexión teórica basada en la revisión de literatura sobre investigaciones que analizan proyectos e iniciativas de inclusión digital y prácticas de usos sociales de las TICs. En la segunda parte del texto, se discuten resultados de una investigación empírica acerca de los usos de las TICs por un colectivo en específico, formado por migrantes transnacionales. Como procedimientos metodológicos, se llevaron a cabo entrevistas en profundidad con un conjunto de más de 200 migrantes latinoamericanos en los contextos de las ciudades de Porto Alegre (Brasil y Barcelona (España. Si bien no se hace una comparación entre políticas de inclusión digital y apropiaciones espontáneas de las TICs, con base en los datos obtenidos, postulamos que importantes avances han sido ignorados por evaluaciones de proyectos que buscan reducir la exclusión digital. Eso se debe a la existencia de una disparidad entre las supuestas necesidades y deseos de grupos sociales que pautan esas iniciativas y las experiencias concretas de apropiaciones por los receptores finales de las iniciativas de inclusión digital.

The Gaia-ESO Survey: Sodium and aluminium abundances in giants and dwarfs. Implications for stellar and Galactic chemical evolution

Science.gov (United States)

Smiljanic, R.; Romano, D.; Bragaglia, A.; Donati, P.; Magrini, L.; Friel, E.; Jacobson, H.; Randich, S.; Ventura, P.; Lind, K.; Bergemann, M.; Nordlander, T.; Morel, T.; Pancino, E.; Tautvaišienė, G.; Adibekyan, V.; Tosi, M.; Vallenari, A.; Gilmore, G.; Bensby, T.; François, P.; Koposov, S.; Lanzafame, A. C.; Recio-Blanco, A.; Bayo, A.; Carraro, G.; Casey, A. R.; Costado, M. T.; Franciosini, E.; Heiter, U.; Hill, V.; Hourihane, A.; Jofré, P.; Lardo, C.; de Laverny, P.; Lewis, J.; Monaco, L.; Morbidelli, L.; Sacco, G. G.; Sbordone, L.; Sousa, S. G.; Worley, C. C.; Zaggia, S.

2016-05-01

Context. Stellar evolution models predict that internal mixing should cause some sodium overabundance at the surface of red giants more massive than ~1.5-2.0 M⊙. The surface aluminium abundance should not be affected. Nevertheless, observational results disagree about the presence and/or the degree of Na and Al overabundances. In addition, Galactic chemical evolution models adopting different stellar yields lead to very different predictions for the behavior of [Na/Fe] and [Al/Fe] versus [Fe/H]. Overall, the observed trends of these abundances with metallicity are not well reproduced. Aims: We readdress both issues, using new Na and Al abundances determined within the Gaia-ESO Survey. Our aim is to obtain better observational constraints on the behavior of these elements using two samples: I) more than 600 dwarfs of the solar neighborhood and of open clusters and II) low- and intermediate-mass clump giants in six open clusters. Methods: Abundances were determined using high-resolution UVES spectra. The individual Na abundances were corrected for nonlocal thermodynamic equilibrium effects. For the Al abundances, the order of magnitude of the corrections was estimated for a few representative cases. For giants, the abundance trends with stellar mass are compared to stellar evolution models. For dwarfs, the abundance trends with metallicity and age are compared to detailed chemical evolution models. Results: Abundances of Na in stars with mass below ~2.0 M⊙, and of Al in stars below ~3.0 M⊙, seem to be unaffected by internal mixing processes. For more massive stars, the Na overabundance increases with stellar mass. This trend agrees well with predictions of stellar evolutionary models. For Al, our only cluster with giants more massive than 3.0 M⊙, NGC 6705, is Al enriched. However, this might be related to the environment where the cluster was formed. Chemical evolution models that well fit the observed [Na/Fe] vs. [Fe/H] trend in solar neighborhood dwarfs

Infectivity-associated PrP(Sc) and disease duration-associated PrP(Sc) of mouse BSE prions.

Science.gov (United States)

Miyazawa, Kohtaro; Okada, Hiroyuki; Masujin, Kentaro; Iwamaru, Yoshifumi; Yokoyama, Takashi

2015-01-01

Disease-related prion protein (PrP(Sc)), which is a structural isoform of the host-encoded cellular prion protein, is thought to be a causative agent of transmissible spongiform encephalopathies. However, the specific role of PrP(Sc) in prion pathogenesis and its relationship to infectivity remain controversial. A time-course study of prion-affected mice was conducted, which showed that the prion infectivity was not simply proportional to the amount of PrP(Sc) in the brain. Centrifugation (20,000 ×g) of the brain homogenate showed that most of the PrP(Sc) was precipitated into the pellet, and the supernatant contained only a slight amount of PrP(Sc). Interestingly, mice inoculated with the obtained supernatant showed incubation periods that were approximately 15 d longer than those of mice inoculated with the crude homogenate even though both inocula contained almost the same infectivity. Our results suggest that a small population of fine PrP(Sc) may be responsible for prion infectivity and that large, aggregated PrP(Sc) may contribute to determining prion disease duration.

Videojuegos y diversidad: construyendo una comunidad de práctica en el aula

Directory of Open Access Journals (Sweden)

Natalia Monjelat

2012-01-01

Full Text Available En el presente trabajo mostraremos como los videojuegos comerciales utilizados como recursos educativos, pueden generar en el aula una comunidad de práctica (Lave & Wenger, 1991, Wenger, 1998, Wenger, White & Smith, 2010 modificando las relaciones entre alumnado y profesor y entre alumnos entre sí Basándonos en una investigación de corte etnográfico y cualitativo (Denzin & Lincoln, 2011; Lacasa & Reina, 2004 analizaremos un taller realizado en un aula de 3º ESO Diversificación donde trabajamos con Sim City Creator . Puntualmente, presentaremos ejemplos de las interacciones generadas entre el alumnado y el profesor, que dan cuenta de cómo el contexto del aula se ha modificado gracias a la introducción del videojuego, generando interacciones diferentes entre sus participantes. Nuestros resultados muestran como el profesor asume el rol de guía, ofreciendo los andamiajes necesarios (Bruner, 1975; Wood, Bruner & Ross, 1976 para avanzar en el juego. Por su parte, los alumnos asumen roles activos en este proceso, ayudándose unos a otros a adquirir mayor control sobre la tarea y un mayor dominio sobre las reglas del juego. Este tipo de uso de las tecnologías en contextos de atención a la diversidad resulta novedoso y responde a una perspectiva sociocultural de atención a la diversidad (Méndez, Lacasa & Matusov, 2008.

Thermodynamic assessment of the Pr-Zn binary system

International Nuclear Information System (INIS)

Huang, X.M.; Liu, L.B.; Zhang, L.G.; Jia, B.R.; Jin, Z.P.; Zheng, F.

2008-01-01

On the basis of available experimental data of phase diagram and thermodynamic properties, the Pr-Zn binary system has been optimized using the CALPHAD approach. The phases, including liquid and bcc A 2(βPr) were treated as substitutional solutions, while the intermetallic compounds, including PrZn, PrZn 2 , PrZn 3 , Pr 3 Zn 11 , Pr 13 Zn 58 , Pr 3 Zn 22 , Pr 2 Zn 17 and PrZn 11 were modeled as stoichiometric compounds. As the result of optimization, a set of self-consistent thermodynamic parameters has been obtained, which can be used to reproduce the reported experimental data

La práctica de actividad física entre los adolescentes de las escuelas públicas del estado en Fortaleza (Brasil

Directory of Open Access Journals (Sweden)

Marta Maria Coelho Damasceno

2009-06-01

Full Text Available El objetivo del estudio fue el de conocer los hábitos cotidianos, relacionados a la práctica de actividad física, mostrados por adolescentes de escuelas públicas de Fortaleza – Brasil. Estudio transversal en el cual participaron 720 estudiantes pertenecientes a doce escuelas públicas estatales, cuya edad variaba entre 14 y 19 años y de ambos sexos. Los datos se recogieron durante los meses de febrero y marzo de 2006, a través de entrevista estructurada. Además, se verificó peso y altura y se midió la glucemia capilar. Los resultados mostraron que el 65,8% tenía entre 14 y 17 años; el 81,1% cursaba enseñanza secundaria; el 59,3% era del sexo femenino y el 75,3% adquirió hábitos sedentarios. De esos, el 10% estaba con sobrepeso; el 2,8% era obeso y el 8,5% tenía sus valores de glucemia capilar superior a lo normal. La práctica de actividad física estuvo relacionada al sexo (p = 0,000 y a la edad (p = 0,049. Se concluyó que hay un alto porcentaje de adolescentes sedentarios y que la educación para la salud es el camino indicado para combatir dicho sedentarismo y también ayuda a prevenir enfermedades cardiovasculares y diabetes mellitus tipo 2.

A Powerful Twin Arrives

Science.gov (United States)

1999-11-01

First Images from FORS2 at VLT KUEYEN on Paranal The first, major astronomical instrument to be installed at the ESO Very Large Telescope (VLT) was FORS1 ( FO cal R educer and S pectrograph) in September 1998. Immediately after being attached to the Cassegrain focus of the first 8.2-m Unit Telescope, ANTU , it produced a series of spectacular images, cf. ESO PR 14/98. Many important observations have since been made with this outstanding facility. Now FORS2 , its powerful twin, has been installed at the second VLT Unit Telescope, KUEYEN . It is the fourth major instrument at the VLT after FORS1 , ISAAC and UVES.. The FORS2 Commissioning Team that is busy installing and testing this large and complex instrument reports that "First Light" was successfully achieved already on October 29, 1999, only two days after FORS2 was first mounted at the Cassegrain focus. Since then, various observation modes have been carefully tested, including normal and high-resolution imaging, echelle and multi-object spectroscopy, as well as fast photometry with millisecond time resolution. A number of fine images were obtained during this work, some of which are made available with the present Press Release. The FORS instruments ESO PR Photo 40a/99 ESO PR Photo 40a/99 [Preview - JPEG: 400 x 345 pix - 203k] [Normal - JPEG: 800 x 689 pix - 563kb] [Full-Res - JPEG: 1280 x 1103 pix - 666kb] Caption to PR Photo 40a/99: This digital photo shows the twin instruments, FORS2 at KUEYEN (in the foreground) and FORS1 at ANTU, seen in the background through the open ventilation doors in the two telescope enclosures. Although they look alike, the two instruments have specific functions, as described in the text. FORS1 and FORS2 are the products of one of the most thorough and advanced technological studies ever made of a ground-based astronomical instrument. They have been specifically designed to investigate the faintest and most remote objects in the universe. They are "multi-mode instruments" that

Mechanistic prospective for human PrPC conversion to PrPSc: Molecular dynamic insights

OpenAIRE

Nooshin Azari; Mohammad Reza Dayer; Nematollah Razmi; Mohammad Saaid Dayer

2013-01-01

PrPC conversion to PrPSc isoform is the main known cause for prion diseases including Crutzfeldt-Jakob, Gerstmann-Sträussler-Sheinker syndrome and fatal familial insomnia in human. The precise mechanism underling this conversion is yet to be well understood. In the present work, using the coordinate file of PrPC (available on the Protein Data Bank) as a starting structure, separate molecular dynamic simulations were carried out at neutral and acidic pH in an explicit water box at 37°C and 1 ...

LA EDUCACIÓN PARA LA SALUD EN LA ESO: APORTACIONES DE UN ESTUDIO SOBRE EL PAÍS VASCO

Directory of Open Access Journals (Sweden)

Amando Vega Fuente

2015-01-01

Full Text Available La educación para la salud en las escuelas es una estrategia necesaria para favorecer comportamientos saludables en el alumnado. Este estudio tiene como objetivo disponer de un conocimiento más preciso sobre las conductas de riesgo de los adolescentes y sobre el tratamiento de las cuestiones de salud en los centros de educación secundaria obligatoria. La prevención del consumo de drogas, la educación afectivo-sexual, la formación para la seguridad vial, la promoción de la salud física y mental son algunos de los aspectos clave para el desarrollo integral de los adolescentes. El trabajo de investigación se llevó a cabo en 24 institutos de ESO del País Vasco y han tomado parte 571 estudiantes. Todos ellos han participado en los programas de educación para la salud subvencionados por el Departamento de Educación del Gobierno Vasco durante los cursos 2010-11 y 2011-12. Los datos obtenidos mediante cuestionarios fueron tratados con el paquete informático SPSS 19.0 e ITEMAN realizándose diversos análisis estadísticos (porcentajes y correlaciones de Pearson. Los resultados obtenidos muestran que las conductas no saludables de los alumnos y alumnas no sólo están relacionadas entre sí, sino también con su bienestar personal y escolar. Se constata, por otra parte, una necesidad clara de que los centros escolares asuman un mayor compromiso con la educación y la promoción de la salud en sus proyectos educativos. Se echa en falta la integración de las cuestiones de salud en los proyectos de los centros, por razones varias, como la falta de una política comprometida con este ámbito educativo, las carencias de formación de los profesores y profesoras y posiblemente la insuficiencia de los recursos dedicados en los centros a la práctica educativa en temas de salud.

Piperazine derivatives inhibit PrP/PrP(res) propagation in vitro and in vivo.

Science.gov (United States)

Leidel, Fabienne; Eiden, Martin; Geissen, Markus; Hirschberger, Thomas; Tavan, Paul; Giese, Armin; Kretzschmar, Hans A; Schätzl, Hermann; Groschup, Martin H

2014-02-28

Prion diseases are fatal neurodegenerative disorders, which are not curable and no effective treatment exists so far. The major neuropathological change in diseased brains is the conversion of the normal cellular form of the prion protein PrPc(C) into a disease-associated isoform PrP(Sc). PrP(Sc) accumulates into multimeres and fibrillar aggregates, which leads to the formation of amyloid plaques. Increasing evidence indicates a fundamental role of PrP(Sc) species and its aggregation in the pathogenesis of prion diseases, which initiates the pathological cascade and leads to neurodegeneration accompanied by spongiform changes. In search of compounds that have the potential to interfere with PrP(Sc) formation and propagation, we used a cell based assay for the screening of potential aggregation inhibitors. The assay deals with a permanently prion infected cell line that was adapted for a high-throughput screening of a compound library composed of 10,000 compounds (DIVERset 2, ChemBridge). We could detect six different classes of highly potent inhibitors of PrP(Sc) propagation in vitro and identified piperazine derivatives as a new inhibitory lead structure, which increased incubation time of scrapie infected mice. Copyright © 2014 Elsevier Inc. All rights reserved.

Shadow of a Large Disc Casts New Light on the Formation of High Mass Stars

Science.gov (United States)

2004-05-01

Massive Star Observed that Forms through a Rotating Accretion Disc Summary Based on a large observational effort with different telescopes and instruments, mostly from the European Southern Observatory (ESO), a team of European astronomers [1] has shown that in the M 17 nebula a high mass star [2] forms via accretion through a circumstellar disc, i.e. through the same channel as low-mass stars. To reach this conclusion, the astronomers used very sensitive infrared instruments to penetrate the south-western molecular cloud of M 17 so that faint emission from gas heated up by a cluster of massive stars, partly located behind the molecular cloud, could be detected through the dust. Against the background of this hot region a large opaque silhouette, which resembles a flared disc seen nearly edge-on, is found to be associated with an hour-glass shaped reflection nebula. This system complies perfectly with a newly forming high-mass star surrounded by a huge accretion disc and accompanied by an energetic bipolar mass outflow. The new observations corroborate recent theoretical calculations which claim that stars up to 40 times more massive than the Sun can be formed by the same processes that are active during the formation of stars of smaller masses. PR Photo 15a/04: Stellar cluster and star-forming region M 17 (also available without text inside photo) PR Photo 15b/04: Silhouette disc seen in M 17 PR Photo 15c/04: Rotation of the disc in M 17. PR Photo 15d/04: Bipolar reflection nebula and silhouette disc of a young, massive star in M 17 PR Photo 15e/04: Optical spectrum of the bipolar nebula. PR Video 03/04: Zooming in onto the disc. The M 17 region ESO PR Photo 15a/04 ESO PR Photo 15a/04 [Preview - JPEG: 400 x 497 pix - 271k] [Normal - JPEG: 800 x 958 pix - 604k] ESO PR Photo 15a1/04 ESO PR Photo 15a/04 (without text within photo) [Preview - JPEG: 400 x 480 pix - 275k] [Normal - JPEG: 800 x 959 pix - 634k] [High-Res - JPEG: 3000 x 3597 pix - 3.8M] [Full-Res - JPEG

Prática docente no Ensino Superior: a formação pedagógica como mobilizadora de mudança

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Kelen dos Santos Junges

2015-06-01

practices a source of learning in a perspective of change and innovation. For this puspose, we chose to present in this text one of the questions that comprised a research thesis and that aims to analyze the pedagogical training as a way of mobilizing change in the teaching practice in higher education.The research methodology adopted was the action research on an educational program with professors in a higher education public institution, called Grupo Docência em Reflexão – GDR (Teaching Reflection Group. Semi-structured interviews were used as instrument of data collection, with ten teachers participating in the training process. The categorization of the data collected revealed that changes in the pedagogical practice of the teachers interviewed, from the activities of the GDR, especially focused on the perception of being a university professor, on the relationship with students, on the didactic organization of classes, on the evaluation of the teaching and learning process, on the reflective practice and on the difficulties encountered by them to implement some change in their practice.So, it was considered that a proposal of pedagogical training that is shared and oriented of the university teachers, based on concrete actions and set in a reflexive perspective, besides a more profound and lasting teacher learning, mobilizes changes in the pedagogical practice of these teachers, encouraging an innovative practice Keywords: University Teaching. Pedagogical Training. Pedagogical Practice.   Práctica docente en la educación superior: la formación pedagógica como movilizadora de cambio  Resumen Se entiende que la formación pedagógica permite al profesor universitario mirar hacia su práctica pedagógica, interpretarla y volver a crearla, tornándola también una fuente de aprendizaje en una perspectiva de cambio y de innovación. Para eso, se optó por presentar en este texto una de las preguntas que formaban una investigación de tesis y tiene como objetivo

Identification and expression analysis of a pathogenresponsive PR ...

African Journals Online (AJOL)

related (PR) proteins. PR-1 genes represent the first identified PR gene family. Most members of PR-1 gene family are not inducible by pathogen attacks. In this study, we identified a pathogen-responsive PR-1 gene designated as VqPR-1 ...

PR Crisis Melalui Media Sosial

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Gladys Carlina

2017-07-01

Full Text Available The background of this research is communication, new media, PR and PR Crisis. Fourth of this background has a close relationship, starting from communication, human in everyday life would require communication to receive and convey information, human can not be released from human life. The advancement of the times and the development of technology, causing people to communicate easily and the development of this era caused a new challenge for the PR and PR Crisis of a company, they should be able to maintain a positive image of the company in the minds of people. In this study using descriptive qualitative methodology, it contains many writings and drawings compared to the numbers. The purpose of this research is to know the strategy used by Pizza Hut in dealing with the issue of expired food. Penelitin results, social media is very positive impact on Pizza Hut in the recovery of food issues expired. The strategy used by the Pizza Hut Crisis PR is to utilize social media. Visible from the issue of expired food that disappeared in public and Pizza Hut restaurant until now crowded visited. Latar belakang dari penelitian ini yaitu komunikasi, media baru, PR dan PR Krisis. Keempat dari latar belakang ini mempunyai hubungan yang erat, dimulai dari komunikasi, manusia di dalam kehidupan sehari-hari tentunya memerlukan komunikasi untuk menerima dan menyampaikan informasi, manusia tidak bisa dilepaskan dari kehidupan manusia. Majunya perkembangan zaman dan perkembangan teknologi, menyebabkan manusia melakukan komunikasi dengan mudah dan perkembangan zaman ini menyebabkan adanya tantangan baru bagi para PR dan PR Krisis sebuah perusahaan, mereka harus bisa mempertahankan citra positif perusahaan di benak masyarakat. Dalam penelitian ini menggunakan metodologi kualitatif deksriptif, memuat banyak tulisan dan gambar dibandingkan angka-angka. Tujuan dari penelitian ini untuk mengetahui strategi yang digunakan oleh Pizza Hut dalam menangani isu makanan

Studies in the Crystalline Electric Field in Pr2 Al and Pr Al by the Inelastic Neutron Scattering Method

International Nuclear Information System (INIS)

Slisenko, V.I.; Ivanitskij, P.G.; Vasil'kevich, A.A.; Krotenko, V.T.; Majstrenko, A.N.

1993-01-01

Results of inelastic neutron scattering in polycrystalline Pr 2 Al and Pr Al are reported. The parameters of the crystal field Hamiltonian for the orthorhombic point symmetry of the Pr 3+ ions in Pr 2 Al and Pr Al are derived from neutron spectra. Using These parameters the magnetic contribution to the specific heat is calculated

Tips for the PR Chairman for Education Associations. PR Bookshelf No. 2.

Science.gov (United States)

National Education Association, Washington, DC.

This booklet is intended to aid leaders of local education associations in developing a continuing public relations (PR) program aimed at establishing and maintaining a favorable public image for teachers. Although it offers useful guidelines for developing a PR program, the booklet does not contain lists of specific things to do. Instead, it…

75 FR 44847 - Proposed Collection; Comment Request for Forms 943, 943-PR, 943-A, and 943A-PR

Science.gov (United States)

2010-07-29

... 943, 943-PR, 943- A, and 943A-PR AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice and... comments concerning Forms 943, Employer's Annual Tax Return for Agricultural Employees, 943-PR, Planilla..., Agricultural Employer's Record of Federal Tax Liability, and 943A-PR, Registro De La Obligacion Contributiva...

Small protease sensitive oligomers of PrPSc in distinct human prions determine conversion rate of PrP(C.

Directory of Open Access Journals (Sweden)

Chae Kim

Full Text Available The mammalian prions replicate by converting cellular prion protein (PrP(C into pathogenic conformational isoform (PrP(Sc. Variations in prions, which cause different disease phenotypes, are referred to as strains. The mechanism of high-fidelity replication of prion strains in the absence of nucleic acid remains unsolved. We investigated the impact of different conformational characteristics of PrP(Sc on conversion of PrP(C in vitro using PrP(Sc seeds from the most frequent human prion disease worldwide, the Creutzfeldt-Jakob disease (sCJD. The conversion potency of a broad spectrum of distinct sCJD prions was governed by the level, conformation, and stability of small oligomers of the protease-sensitive (s PrP(Sc. The smallest most potent prions present in sCJD brains were composed only of∼20 monomers of PrP(Sc. The tight correlation between conversion potency of small oligomers of human sPrP(Sc observed in vitro and duration of the disease suggests that sPrP(Sc conformers are an important determinant of prion strain characteristics that control the progression rate of the disease.

In vivo bone regeneration using a novel porous bioactive composite

Energy Technology Data Exchange (ETDEWEB)

Xie En [Department of Orthopaedics and Traumatology, Xijing Hospital, Fourth Military Medical University, Xi' an (China); Hu Yunyu [Department of Orthopaedics and Traumatology, Xijing Hospital, Fourth Military Medical University, Xi' an (China)], E-mail: orth1@fmmn.edu.cn; Chen Xiaofeng [College of Materials Science and Engineering, South China University of Technology University, Guangzhou (China); Bai Xuedong; Li Dan [Department of Orthopaedics and Traumatology, Xijing Hospital, Fourth Military Medical University, Xi' an (China); Ren Li [College of Materials Science and Engineering, South China University of Technology University, Guangzhou (China); Zhang Ziru [Foreign Languages School, Northwest University Xi' an (China)

2008-11-15

Many commercial bone graft substitutes (BGS) and experimental bone tissue engineering scaffolds have been developed for bone repair and regeneration. This study reports the in vivo bone regeneration using a newly developed porous bioactive and resorbable composite that is composed of bioactive glass (BG), collagen (COL), hyaluronic acid (HYA) and phosphatidylserine (PS), BG-COL-HYA-PS. The composite was prepared by a combination of sol-gel and freeze-drying methods. A rabbit radius defect model was used to evaluate bone regeneration at time points of 2, 4 and 8 weeks. Techniques including radiography, histology, and micro-CT were applied to characterize the new bone formation. 8 weeks results showed that (1) nearly complete bone regeneration was achieved for the BG-COL-HYA-PS composite that was combined with a bovine bone morphogenetic protein (BMP); (2) partial bone regeneration was achieved for the BG-COL-HYA-PS composites alone; and (3) control remained empty. This study demonstrated that the novel BG-COL-HYA-PS, with or without the grafting of BMP incorporation, is a promising BGS or a tissue engineering scaffold for non-load bearing orthopaedic applications.

In vivo bone regeneration using a novel porous bioactive composite

International Nuclear Information System (INIS)

Xie En; Hu Yunyu; Chen Xiaofeng; Bai Xuedong; Li Dan; Ren Li; Zhang Ziru

2008-01-01

Many commercial bone graft substitutes (BGS) and experimental bone tissue engineering scaffolds have been developed for bone repair and regeneration. This study reports the in vivo bone regeneration using a newly developed porous bioactive and resorbable composite that is composed of bioactive glass (BG), collagen (COL), hyaluronic acid (HYA) and phosphatidylserine (PS), BG-COL-HYA-PS. The composite was prepared by a combination of sol-gel and freeze-drying methods. A rabbit radius defect model was used to evaluate bone regeneration at time points of 2, 4 and 8 weeks. Techniques including radiography, histology, and micro-CT were applied to characterize the new bone formation. 8 weeks results showed that (1) nearly complete bone regeneration was achieved for the BG-COL-HYA-PS composite that was combined with a bovine bone morphogenetic protein (BMP); (2) partial bone regeneration was achieved for the BG-COL-HYA-PS composites alone; and (3) control remained empty. This study demonstrated that the novel BG-COL-HYA-PS, with or without the grafting of BMP incorporation, is a promising BGS or a tissue engineering scaffold for non-load bearing orthopaedic applications

78 FR 47051 - Proposed Collection; Comment Request for Forms 943, 943-PR, 943-A, and 943A-PR

Science.gov (United States)

2013-08-02

... 943, 943-PR, 943- A, and 943A-PR AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice and..., 943-PR, Planilla Para La Declarcion Anual De La Contribucion Federal Del Patrono De Empleados Agricolas, 943-A, Agricultural Employer's Record of Federal Tax Liability, and 943A-PR, Registro De La...

Die prädikatsergänzung (das prädikatsattribut in der Slovenischen Syntax

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Breda Pogorelec

1972-12-01

Full Text Available In der vorliegenden Abhandlung wird die erwähnte Problematik in der slovenischen grammatischen -Überlieferung behandelt und mit interessanten Ergebnissen vor allem der tschechischen Sprachtheorie ergänzt, es wird der Terminus Prädikatsergänzung gegenüber dem Terminus Prädikatsattribut begründet; auf dieser Grundlage werden auch die bisher behandelten Arten von Prädikatsergänzungen mit neuen ergänzt. Dabei findet wenn nur möglich das einfache Transformationsverfahren Verwendung, das die Veranschaulichung der stufenweisen Determinierung durch das Prädikatsattribut ermöglicht. Das Material entstammt vorwiegend der Sprache der Kunst, der Grund dafür ist vor allem in der Tatsache zu suchen, daß in dieser Sprache dieser Form die Rolle eines natürlichen Kondensators zufällt, weshalb sie verhältnismäßig häufig vorkommt. Die Abhandlung befaßt sich eingehender auch mit dem Problem der Wortfolge und berührt auch die graphische Darstellung der bei der Prädikatsergänzung üblichen Pausen.

Bolonia y la buena práctica de las prácticas

OpenAIRE

García Delgado, Javier

2016-01-01

A propósito de la implantación del controvertido “plan Bolonia” se están difundiendo algunas ideas negativas en relación con una supuesta “mercantilización” de la universidad, algunas relacionadas con la explotación de los estudiantes a través de las prácticas en empresas, o prácticas externas, sobre las cuales se reflexiona en este artículo. ¿Qué hemos aprendido tras las ya casi tres décadas transcurridas desde la promulgación del decreto del año 81 que autorizaba este tipo de prácticas? Ese...

PrPST, a Soluble, Protease Resistant and Truncated PrP Form Features in the Pathogenesis of a Genetic Prion Disease

Science.gov (United States)

Frid, Kati; Binyamin, Orli; Gabizon, Ruth

2013-01-01

While the conversion of PrPC into PrPSc in the transmissible form of prion disease requires a preexisting PrPSc seed, in genetic prion disease accumulation of disease related PrP could be associated with biochemical and metabolic modifications resulting from the designated PrP mutation. To investigate this possibility, we looked into the time related changes of PrP proteins in the brains of TgMHu2ME199K/wt mice, a line modeling for heterozygous genetic prion disease linked to the E200K PrP mutation. We found that while oligomeric entities of mutant E199KPrP exist at all ages, aggregates of wt PrP in the same brains presented only in advanced disease, indicating a late onset conversion process. We also show that most PK resistant PrP in TgMHu2ME199K mice is soluble and truncated (PrPST), a pathogenic form never before associated with prion disease. We next looked into brain samples from E200K patients and found that both PK resistant PrPs, PrPST as in TgMHu2ME199K mice, and “classical” PrPSc as in infectious prion diseases, coincide in the patient's post mortem brains. We hypothesize that aberrant metabolism of mutant PrPs may result in the formation of previously unknown forms of the prion protein and that these may be central for the fatal outcome of the genetic prion condition. PMID:23922744

HIV-negative male couples' attitudes about pre-exposure prophylaxis (PrEP) and using PrEP with a sexual agreement.

Science.gov (United States)

Mitchell, Jason W; Lee, Ji-Young; Woodyatt, Cory; Bauermeister, José; Sullivan, Patrick; Stephenson, Rob

2016-08-01

One efficacious strategy to help prevent HIV is oral pre-exposure prophylaxis (PrEP), a daily regimen of antiretroviral treatment taken by HIV-negative individuals. Two of the recommendations of Centers for Disease Control and Prevention (CDC) guidelines for PrEP pertain to being in a relationship (i.e., male couples). Despite the recognition of how primary partners in male couples' relationships shape HIV risk and CDC's PrEP guidelines, there is a paucity of data that examine HIV-negative male couples' attitudes toward PrEP use and using PrEP with a sexual agreement. A sexual agreement is an explicit agreement made between two individuals about what sex and other related behaviors may occur within and outside of their relationship. In this qualitative study, we examine HIV-negative male couples' attitudes toward PrEP use and whether they thought PrEP could be integrated into a sexual agreement. Data for this study are drawn from couple-level interviews conducted in 2014 with 29 HIV-negative male couples who had a sexual agreement and were from Atlanta or Detroit. Both passive (e.g., flyers) and active (e.g., targeted Facebook advertisements) recruitment methods were used; the sample was stratified by agreement type. Thematic analysis was applied to identify the following themes regarding HIV-negative male couples' attitudes toward PrEP use: (1) PrEP and condom use; (2) concerns about PrEP (e.g., effectiveness, side effects, and promoting sexually risky behavior); and (3) accessibility of PrEP. Some thought PrEP could be a part of couples' agreement because it could help reduce sexual anxiety and sexual risk, and would help keep the couple safe. Others described PrEP use with an agreement as something for "others". Some were also concerned that incorporating PrEP could usurp the need for a sexual agreement in a couples' relationship. These themes highlight the need to improve informational messaging and promotion efforts about PrEP among HIV-negative male couples

The Great Easter Egg Hunt: The Void's Incredible Richness

Science.gov (United States)

2006-04-01

An image made of about 300 million pixels is being released by ESO, based on more than 64 hours of observations with the Wide-Field Camera on the 2.2m telescope at La Silla (Chile). The image covers an 'empty' region of the sky five times the size of the full moon, opening an exceptionally clear view towards the most distant part of our universe. It reveals objects that are 100 million times fainter than what the unaided eye can see. Easter is in many countries a time of great excitement for children who are on the big hunt for chocolate eggs, hidden all about the places. Astronomers, however, do not need to wait this special day to get such an excitement: it is indeed daily that they look for faraway objects concealed in deep images of the sky. And as with chocolate eggs, deep sky objects, such as galaxies, quasars or gravitational lenses, come in the wildest variety of colours and shapes. ESO PR Photo 11/06 ESO PR Photo 14a/06 The Deep 3 'Empty' Field The image presented here is one of such very deep image of the sky. It is the combination of 714 frames for a total exposure time of 64.5 hours obtained through four different filters (B, V, R, and I)! It consists of four adjacent Wide-Field Camera pointings (each 33x34 arcmin), covering a total area larger than one square degree. Yet, if you were to look at this large portion of the firmament with the unaided eye, you would just see... nothing. The area, named Deep 3, was indeed chosen to be a random but empty, high galactic latitude field, positioned in such a way that it can be observed from the La Silla observatory all over the year. Together with two other regions, Deep 1 and Deep 2, Deep 3 is part of the Deep Public Survey (DPS), based on ideas submitted by the ESO community and covering a total sky area of 3 square degrees. Deep 1 and Deep 2 were selected because they overlapped with regions of other scientific interest. For instance, Deep 1 was chosen to complement the deep ATESP radio survey carried out

PrEP Whores and HIV Prevention: The Queer Communication of HIV Pre-Exposure Prophylaxis (PrEP).

Science.gov (United States)

Spieldenner, Andrew

2016-12-01

HIV pre-exposure prophylaxis (PrEP) has been introduced as another biomedical tool in HIV prevention. Whereas other such tools-including post-exposure prophylaxis (PEP) and interruption of perinatal transmission-have been embraced by those impacted by HIV, PrEP has been met with more conflict, especially within the gay community and HIV organizations. The "PrEP whore" has come to designate the social value and personal practices of those taking PrEP. This study examines the "PrEP whore" discourse by using queer theory and quare theory. Within these theoretical vantage points, the study explicates four discursive areas: slut shaming, dirty/clean binaries, mourning the loss of condoms, and reclaiming the inner whore. The study illuminates possible discursive strategies that lie outside of the domains of public health and within the individual and community.

Incorporation of Pr into LuAG ceramics

Science.gov (United States)

Marchewka, M. R.; Chapman, M. G.; Qian, H.; Jacobsohn, L. G.

2017-06-01

An investigation of the effects of Pr in (Lu1-xPrx)3Al5O12 (LuAG:Pr) ceramics was carried out by means of x-ray diffraction (XRD), energy dispersive x-ray spectroscopy (EDX), and attenuated total reflection Fourier transform infrared spectroscopy (ATR FTIR) measurements coupled with luminescence measurements. It was found that the Pr concentration that maximizes luminescence emission depends on the thermal processing conditions. While the calcined LuAG:Pr powder showed maximum luminescence emission for Pr concentrations between 0.18 and 0.33 at.%, maximum emission of ceramic bodies sintered at 1500 °C for 20 h was obtained with Pr concentrations between 0.018 and 0.18 at.%. Further, for short sintering times up to about 3 h, luminescence emission intensity is maximum for Pr concentrations around 0.33 at.%. Longer sintering times lead to the formation of PrAlO3 as a secondary phase, concomitant with a reduction of the intensity of luminescence emission.

PrPC from stem cells to cancer

Directory of Open Access Journals (Sweden)

Séverine eMartin-Lannerée

2014-09-01

Full Text Available The cellular prion protein PrPC was initially discovered as the normal counterpart of the pathological scrapie prion protein PrPSc, the main component of the infectious agent of Transmissible Spongiform Encephalopathies. While clues as to the physiological function of this ubiquitous protein were greatly anticipated from the development of knock-out animals, PrP-null mice turned out to be viable and to develop without major phenotypic abnormalities. Notwithstanding, the discovery that hematopoietic stem cells from PrP-null mice have impaired long-term repopulating potential has set the stage for investigating into the role of PrPC in stem cell biology. A wealth of data have now exemplified that PrPC is expressed in distinct types of stem cells and regulates their self-renewal as well as their differentiation potential. A role for PrPC in the fate restriction of embryonic stem cells has further been proposed. Paralleling these observations, an overexpression of PrPC has been documented in various types of tumours. In line with the contribution of PrPC to stemness and to the proliferation of cancer cells, PrPC was recently found to be enriched in subpopulations of tumour-initiating cells. In the present review, we summarize the current knowledge of the role played by PrPC in stem cell biology and discuss how the subversion of its function may contribute to cancer progression.

PrP-C1 fragment in cattle brains reveals features of the transmissible spongiform encephalopathy associated PrPsc.

Science.gov (United States)

Serra, Fabienne; Müller, Joachim; Gray, John; Lüthi, Ramona; Dudas, Sandor; Czub, Stefanie; Seuberlich, Torsten

2017-03-15

Three different types of bovine spongiform encephalopathy (BSE) are known and supposedly caused by distinct prion strains: the classical (C-) BSE type that was typically found during the BSE epidemic, and two relatively rare atypical BSE types, termed H-BSE and L-BSE. The three BSE types differ in the molecular phenotype of the disease associated prion protein, namely the N-terminally truncated proteinase K (PK) resistant prion protein fragment (PrP res ). In this study, we report and analyze yet another PrP res type (PrP res-2011 ), which was found in severely autolytic brain samples of two cows in the framework of disease surveillance in Switzerland in 2011. Analysis of brain tissues from these animals by PK titration and PK inhibitor assays ruled out the process of autolysis as the cause for the aberrant PrP res profile. Immunochemical characterization of the PrP fragments present in the 2011 cases by epitope mapping indicated that PrP res-2011 corresponds in its primary sequence to the physiologically occurring PrP-C1 fragment. However, high speed centrifugation, sucrose gradient assay and NaPTA precipitation revealed biochemical similarities between PrP res-2011 and the disease-associated prion protein found in BSE affected cattle in terms of detergent insolubility, PK resistance and PrP aggregation. Although it remains to be established whether PrP res-2011 is associated with a transmissible disease, our results point out the need of further research on the role the PrP-C1 aggregation and misfolding in health and disease. Copyright © 2017. Published by Elsevier B.V.

STRATEGIJSKA ULOGA PR U SPORTU

Directory of Open Access Journals (Sweden)

Duško Tomić

2005-05-01

Full Text Available PR in the modern world are developed with rapid speed and become important aspect of strategic management. Modern menagers are very interesting in PR and they observe that there is not successful strategy without experiance theory and practice in PR. The goals must be defined, basic phylosophy to, and managers must take responsability and describe everithing what they have to do. It must be financial fond and evaluation must be done

Progesterone receptors (PR) mediate STAT actions: PR and prolactin receptor signaling crosstalk in breast cancer models.

Science.gov (United States)

Leehy, Katherine A; Truong, Thu H; Mauro, Laura J; Lange, Carol A

2018-02-01

Estrogen is the major mitogenic stimulus of mammary gland development during puberty wherein ER signaling acts to induce abundant PR expression. PR signaling, in contrast, is the primary driver of mammary epithelial cell proliferation in adulthood. The high circulating levels of progesterone during pregnancy signal through PR, inducing expression of the prolactin receptor (PRLR). Cooperation between PR and prolactin (PRL) signaling, via regulation of downstream components in the PRL signaling pathway including JAKs and STATs, facilitates the alveolar morphogenesis observed during pregnancy. Indeed, these pathways are fully integrated via activation of shared signaling pathways (i.e. JAKs, MAPKs) as well as by the convergence of PRs and STATs at target genes relevant to both mammary gland biology and breast cancer progression (i.e. proliferation, stem cell outgrowth, tissue cell type heterogeneity). Thus, rather than a single mediator such as ER, transcription factor cascades (ER>PR>STATs) are responsible for rapid proliferative and developmental programming in the normal mammary gland. It is not surprising that these same mediators typify uncontrolled proliferation in a majority of breast cancers, where ER and PR are most often co-expressed and may cooperate to drive malignant tumor progression. This review will primarily focus on the integration of PR and PRL signaling in breast cancer models and the importance of this cross-talk in cancer progression in the context of mammographic density. Components of these PR/PRL signaling pathways could offer alternative drug targets and logical complements to anti-ER or anti-estrogen-based endocrine therapies. Copyright © 2017 Elsevier Ltd. All rights reserved.

Determination of the differences in oxidation potentials for the Pr3+/Pr2+ and Ce3+/Ce2+ pairs in halide melts

International Nuclear Information System (INIS)

Mikheev, N.B.; Auerman, L.N.; Rumer, I.A.; D'yachkova, R.A.

1983-01-01

Cocrystallization has been used with the (PrOCl)/sub s. ph/ - (PrCl 2 , PrCl 3 , SrCl 2 ) melt system to examine the dependence of the cerium(III) cocrystallization coefficient on the X/sub Pr 2+ /X/sub Pr 3+ / ratio in the melt. Measurement has been made in this way of the difference in oxidation potentials for the pairs Pr 3+ /Pr 2+ and Ce 3+ /Ce 2+ : ΔE/sub Pr 3+ /Pr 2+0 -E/sub Ce 3+ /Ce 2+ / 0 , which is 0.08 +/- 0.04 V for chloride

Electronic structures of PrBa2Cu3O7, Pr2Ba4Cu7O15-y(y=0,1), and PrBa2Cu4O8 based on LSDA+U method

International Nuclear Information System (INIS)

Tavana, A.; Shirazi, M.; Akhavan, M.

2009-01-01

The electronic structures of PrBa 2 Cu 3 O 7 (Pr123), Pr 2 Ba 4 Cu 7 O 15-y (Pr247), and PrBa 2 Cu 4 O 8 (Pr124) cuprates have been obtained using density-functional theory in the local spin density approximation plus onsite Coulomb interaction (LSDA+U). Onsite Hubbard correlation, U, has been considered for Pr-f and Cu-d orbitals and the effects of considering these correlation corrections on the Pr-O hybridizations have been inspected. Results imply that the Pr ionization state in Pr123 system is constituted from two different configurations, and the energy of the f states in these two configurations has an important role in superconductivity properties of the system. Our calculations also show that in both Pr124 and Pr247 systems, suppression of superconductivity is weaker than that in the Pr123 system. This occurs due to the weaker Pr-O bond in both Pr124 and Pr247 systems. The role of the double chain and single chain on the conduction properties of these compounds has been investigated. We have also studied the effect of oxygen deficiency in Pr247 system, which seems to revive superconductivity in this system. Investigating the hole carriers in the CuO 2 plane shows a correlation between superconductivity suppression and hole decrement in the planes. (Abstract Copyright [2009], Wiley Periodicals, Inc.)

On the nature of the dhcp to fcc transition under pressure in Pr and Pr-Th alloys

International Nuclear Information System (INIS)

Vijayakumar, V.; Godwal, B.K.; Sikka, S.K.; Chidambaram, R.

1988-01-01

The results of electrical resistance (R), thermoelectric power (TEP) and X-ray diffraction measurements on praseodymium (Pr) and its alloys with thorium under pressure are reported. The maximum in R vs P curve exhibited by Pr persists only in the dhcp phase of Pr-Th alloy. X-ray measurements confirmed that in the alloys also the maximum in R vs P curve is due to the dhcp → fcc transition. Thus the behaviour of Pr and Pr-Th alloys is different from that of La and its alloys with Ce and Th where the maximum in the R vs P curve is electronic in origin and is exhibited by the dhcp, fcc and dist fcc phases. (author). 14 refs

Molecular insights on analogs of HIV PR inhibitors toward HTLV-1 PR through QM/MM interactions and molecular dynamics studies: comparative structure analysis of wild and mutant HTLV-1 PR.

Science.gov (United States)

Selvaraj, Chandrabose; Singh, Poonam; Singh, Sanjeev Kumar

2014-12-01

Retroviruses HTLV-1 and HIV-1 are the primary causative agents of fatal adult T-cell leukemia and acquired immune deficiency syndrome (AIDS) disease. Both retroviruses are similar in characteristics mechanism, and it encodes for protease that mainly involved in the viral replication process. On the basis of the therapeutic success of HIV-1 PR inhibitors, the protease of HTLV-1 is mainly considered as a potential target for chemotherapy. At the same time, structural similarities in both enzymes that originate HIV PR inhibitors can also be an HTLV-1 PR inhibitor. But the expectations failed because of rejection of HIV PR inhibitors from the HTLV-1 PR binding pocket. In this present study, the reason for the HIV PR inhibitor rejection from the HTLV-1 binding site was identified through sequence analysis and molecular dynamics simulation method. Functional analysis of M37A mutation in HTLV PR clearly shows that the MET37 specificity and screening of potential inhibitors targeting MET37 is performed by using approved 90% similar HIV PR inhibitor compounds. From this approach, we report few compounds with a tendency to accept/donate electron specifically to an important site residue MET37 in HTLV-1 PR binding pocket. Copyright © 2014 John Wiley & Sons, Ltd.

One-Pot Conversion of Epoxidized Soybean Oil (ESO into Soy-Based Polyurethanes by MoCl2O2 Catalysis

Directory of Open Access Journals (Sweden)

Vincenzo Pantone

2017-02-01

Full Text Available An innovative and eco-friendly one-pot synthesis of bio-based polyurethanes is proposed via the epoxy-ring opening of epoxidized soybean oil (ESO with methanol, followed by the reaction of methoxy bio-polyols intermediates with 2,6-tolyl-diisocyanate (TDI. Both synthetic steps, methanolysis and polyurethane linkage formation, are promoted by a unique catalyst, molybdenum(VI dichloride dioxide (MoCl2O2, which makes this procedure an efficient, cost-effective, and environmentally safer method amenable to industrial scale-up.

Pr4N2S3 and Pr4N2Se3: two non-isostructural praseodymium(iii) nitride chalcogenides

International Nuclear Information System (INIS)

Lissner, Falk; Schleid, Thomas

2005-01-01

The non-isostructural nitride chalcogenides of praseodymium, Pr 4 N 2 S 3 and Pr 4 N 2 Se 3 , are formed by the reaction of the praseodymium metal with sodium azide (NaN 3 ), praseodymium trihalide (PrX 3 ; X = Cl, Br, I) and the respective chalcogen (sulfur or selenium) at 900 C in evacuated silica ampoules after seven days. Both crystallize monoclinically in space group C2/c (Pr 4 N 2 S 3 : a = 1788.57(9), b = 986.04(5), c = 1266.49(6) pm, β = 134.546(7) , Z = 8; Pr 4 N 2 Se 3 : a = 1311.76(7), b = 1017.03(5), c = 650.42(3) pm, β = 90.114(6) , Z = 4). The crystal structures of both compounds show a layered construction, dominated by N 3- -centred (Pr 3+ ) 4 tetrahedra which share a common edge first. Continuing linkage of the so resulting bitetrahedral [N 2 Pr 6 ] 12+ units via the non-connected vertices to layers according to [stack ∞ 2 ]{[N(Pr) 2/2 e (Pr') 2/2 v ] 3+ } forms different kinds of tetrahedral nets which can be described as layers consisting of ''four- and eight-rings'' for Pr 4 N 2 S 3 and as layers of ''six-rings'' for Pr 4 N 2 Se 3 . Whereas the crystal structure of Pr 4 N 2 S 3 exhibits four different Pr 3+ cations with coordination numbers of six (2 x) and seven (2 x) against N 3- and S 2- , the number of cations in the nitride selenide (Pr 4 N 2 Se 3 ) is reduced to half (Pr1 and Pr2) also having six- and sevenfold anionic coordination spheres. Further motifs for the connection of [NM 4 ] 9+ tetrahedra in crystal structures of nitride chalcogenides and halides of the rare-earth elements with ratios of N: M = 1: 2 are presented and discussed. (Abstract Copyright [2005], Wiley Periodicals, Inc.) [de

Energy transfer between Pr3+ and Mn2+ in K2YZr(PO4)3: Pr, Mn phosphor

International Nuclear Information System (INIS)

Liang Wei; Wang Yuhua

2011-01-01

Research highlights: → Pr 3+ , Mn 2+ co-doped K 2 YZr(PO 4 ) 3 phosphor is a novel type of practical visible quantum cutting phosphor in promising application. → The optimal quantum efficiency (QE) of this co-doped system K 2 YZr(PO 4 ) 3 : Pr 3+ , Mn 2+ reached to 126.3%. → The Mn 2+6 A 1g → 4 E g - 4 A 1g transition was found to coincide well with the 1 S 0 → 1 I 6 transition of Pr 3+ . → The energy transfer from Pr 3+ to Mn 2+ was also observed, converting the first photon from the PCE of Pr 3+ into the red emission of Mn 2+ , and the QC process occurred in this Pr 3+ , Mn 2+ co-doped K 2 YZr(PO 4 ) 3 phosphor. - Abstract: Pr 3+ , Mn 2+ co-doped K 2 YZr(PO 4 ) 3 samples were prepared by solid-state reaction method and their photoluminescence (PL) properties were investigated in ultra-violet (UV) and vacuum ultra-violet (VUV) region. The results indicated that in Pr 3+ singly doped K 2 YZr(PO 4 ) 3 sample, the first-step transition ( 1 S 0 → 1 I 6 , 3 P J around 405 nm) of Pr 3+ is near the ultraviolet (UV) range, not useful for practical application. When Mn 2+ was doped as a co-activator ion, the energy of 1 S 0 → 1 I 6 , 3 P J transition can be transferred synchronously from Pr 3+ to Mn 2+ and then emit a visible photon. The optimal quantum efficiency (QE) of this co-doped system K 2 YZr(PO 4 ) 3 : Pr 3+ , Mn 2+ reached to 126.3%, suggesting a novel type of practical visible quantum cutting phosphor in promising application.

E-PR technologies in political party activities

OpenAIRE

Tereshchuk Vitaliy Ivanovych

2016-01-01

The article discusses the role of the Internet as an important communicative tool in the field of political PR. The article reviews the characteristics of PR-activities on the Internet and the features of e-PR in the political sphere. Particular attention is paid to the system of political party’s e-PR tools.

Phase diagrams of Pr-C system

International Nuclear Information System (INIS)

Eremenko, V.N.; Velikanova, T.Ya.; Gordijchuk, O.V.

1988-01-01

Results of the X-ray phase, metallographic and high-temperature differential thermal analysis are used for the first time to plot a diagram of the Pr-C system state. Carbides are formed in the system: Pr 2 C 3 with the bcc-structure of the Pu 2 C 3 type and with the period a 0 = 0.85722+-0.00026 within the phase region + 2 C 3 >, a 0 0.86078+-0.00016 nm - within the region 2 C 3 >+α-PrC 2 ; dimorphous PrC 2 : α-PrC 2 with the bct-structure of the CaC 2 type and periods a 0.38517+-0.00011, c 0 = 0.64337+-0.00019 nm; β-PrC 2 with the fcc-structure, probably, of KCN type. Dicarbide melts congruently at 2320 grad. C, forming eutectics with graphite at 2254+-6 grad. C and composition of 71.5% (at.)C. It is polymorphously transformed in the phase region 2 C 3 > + 2 > at 1145+-4 grad. C, and in the region 2 >+C at 1134+-4 grad. C. Sesquicarbide melts incongruently at 1545+-4 grad. C. The eutectic reaction L ↔ + 2 C 3 > occurs at 800+-4 grad. C, the eutectic composition ∼ 15% (at.)C. The temperature of the eutectoid reaction ↔ + 2 C 3 > is 675+-6 grad C. The limiting carbon solubility in β-Pr is about 8 and in α-Pr it is about 5% (at.)

Discovery of a Kiloparsec Extended Hard X-Ray Continuum and Fe-Kα from the Compton Thick AGN ESO 428-G014

Science.gov (United States)

Fabbiano, G.; Elvis, M.; Paggi, A.; Karovska, M.; Maksym, W. P.; Raymond, J.; Risaliti, G.; Wang, Junfeng

2017-06-01

We report the discovery of kiloparsec-scale diffuse emission in both the hard continuum (3-6 keV) and in the Fe-Kα line in the Compton thick (CT) Seyfert galaxy ESO 428-G014. This extended hard component contains at least ˜24% of the observed 3-8 keV emission, and follows the direction of the extended optical line emission (ionization cone) and radio jet. The extended hard component has ˜0.5% of the intrinsic 2-10 keV luminosity within the bi-cones. A uniform scattering medium of density 1 {{cm}}-3 would produce this luminosity in a 1 kpc path length in the bi-cones. Alternatively, higher column density molecular clouds in the disk of ESO 428-G014 may be responsible for these components. The continuum may also be enhanced by the acceleration of charged particles in the radio jet. The steeper spectrum (Γ ˜ 1.7 ± 0.4) of the hard continuum outside of the central 1.″5 radius nuclear region suggests a contribution of scattered/fluorescent intrinsic Seyfert emission. Ultrafast nuclear outflows cannot explain the extended Fe-Kα emission. This discovery suggests that we may need to revise the picture at the base of our interpretation of CT AGN spectra.

Internet innovation in PR management

Directory of Open Access Journals (Sweden)

Ćalasan Veljko B.

2014-01-01

Full Text Available PR Management in the last decade has evolved to unimaginable limits . Its rapid 'evolution ' is directly linked to the development and innovation, above all, of internet communications - Cyber 'world'. Although the genesis of PR management was announced in a way, the changes of the modern PR management have led to a change in the general attitude towards this particular activity. It has become an indispensable factor for the success of every business or social enterprise. In the general run for internet contents with better quality, as an indispensable tool of PR management , for better use of cyberspace , a new generation of PR manager is created, who has almost no resemblance to the earlier managers before two decades. For these reasons, we believe that Internet innovation through the implementation of PR management, changed the world economy and society. Adjusting speed to this, virtual , yet very real world , is proportional to the speed of development of an economic system as a whole, or any company at the micro level , and society in general .Internet is not an important innovation itself to be sufficient to meet the form and define the essence of economic relations. Only its proper exploitation with the constant use of tested and more intense innovation is the only way to the overall success . The absence of the above, in our opinion, is a sure path to failure.

New Portraits of Spiral Galaxies NGC 613, NGC 1792 and NGC 3627

Science.gov (United States)

2003-12-01

Not so long ago, the real nature of the "spiral nebulae", spiral-shaped objects observed in the sky through telescopes, was still unknown. This long-standing issue was finally settled in 1924 when the famous American astronomer Edwin Hubble provided conclusive evidence that they are located outside our own galaxy and are in fact "island universes" of their own. Nowadays, we know that the Milky Way is just one of billions of galaxies in the Universe. They come in vastly different shapes - spiral, elliptical, irregular - and many of them are simply beautiful, especially the spiral ones. Astronomers Mark Neeser from the Universitäts-Sternwarte München (Germany) and Peter Barthel from the Kapteyn Institute in Groningen (The Netherlands) were clearly not insensitive to this when they obtained images of three beautiful spiral galaxies with ESO's Very Large Telescope (VLT). They did this in twilight during the early morning when they had to stop their normal observing programme, searching for very distant and faint quasars. The resulting colour images ( ESO PR Photos 33a-c/03 ) were produced by combining several CCD images in three different wavebands from the FORS multi-mode instruments. The three galaxies are known as NGC 613, NGC 1792 and NGC 3627 . They are characterized by strong far-infrared, as well as radio emission, indicative of substantial ongoing star-formation activity. Indeed, these images all display prominent dust as well as features related to young stars, clear signs of intensive star-formation. NGC 613 ESO PR Photo 33a/03 ESO PR Photo 33a/03 [Preview - JPEG: 470 x 400 pix - 25k] [Normal - JPEG: 939 x 800 pix - 416k] [Full Res - JPEG: 2702 x 2301 pix - 3.4M] PR Photo 33a/03 of the barred spiral galaxy NGC 613 was obtained with the FORS1 and FORS2 multi-mode instruments (at VLT MELIPAL and YEPUN, respectively) on December 16-18, 2001. It is a composite of three exposures in different wavebands, cf. the technical note below. The full-resolution version

KEZKAK: cuestionario bilingüe de estresores de los estudiantes de enfermería en las prácticas clínicas

Directory of Open Access Journals (Sweden)

Zupiria Gorostidi X.

2003-01-01

Full Text Available Objetivo: Construir y validar un cuestionario bilingüe (castellano/euskera para medir los estresores que tienen los estudiantes de enfermería en las prácticas clínicas. Metodos: Se ha partido de las ideas recogidas fundamentalmente en reuniones realizadas con los alumnos. En un primer momento 287 estudiantes de enfermería de la Escuela de Enfermería de San Sebastián respondieron a la versión inicial de 55 ítemes y al cuestionario STAI de ansiedad. Tras la depuración por ítem-análisis, se ha obtenido la versión final de 41 ítemes. Algunos de los sujetos respondieron nuevamente la versión final a los 2 meses (n = 198 y a los 6 meses (n = 211. Resultados: El cuestionario presenta una alta consistencia interna (α de Cronbach, 0,95, una fiabilidad considerable (0,72 a los 2 meses y 0,68 a los 6 meses, y una validez concurrente aceptable (0,39 con ansiedad-rasgo. El anαlisis factorial arroja nueve factores que tienen una alta consistencia interna y explican el 64,4% de la varianza. Segϊn esos factores, los principales estresores para los estudiantes de enfermería en las prácticas clínicas se derivan de la falta de competencia (11,2%, del contacto con el sufrimiento (9,1%, de la relación con tutores y compañeros (8,9%, de la impotencia e incertidumbre (7,7%, de no controlar la relación con el enfermo (7,6%, de la implicación emocional (5,8%, de la relación con el enfermo (dañarse en la relación [5,2%] y el enfermo busca una relación íntima [4,6%] y de la sobrecarga (4,3%. Se discuten aspectos metodológicos y prácticos del cuestionario y su utilidad en la planificación pedagógica de futuras enfermeras. Conclusión: El cuestionario KEZKAK es un instrumento útil para medir los estresores de los estudiantes de enfermería en las prácticas clínicas.

A Portrait of One Hundred Thousand and One Galaxies

Science.gov (United States)

2002-08-01

Rich and Inspiring Experience with NGC 300 Images from the ESO Science Data Archive Summary A series of wide-field images centred on the nearby spiral galaxy NGC 300 , obtained with the Wide-Field Imager (WFI) on the MPG/ESO 2.2-m telescope at the La Silla Observatory , have been combined into a magnificent colour photo. These images have been used by different groups of astronomers for various kinds of scientific investigations, ranging from individual stars and nebulae in NGC 300, to distant galaxies and other objects in the background. This material provides an interesting demonstration of the multiple use of astronomical data, now facilitated by the establishment of extensively documented data archives, like the ESO Science Data Archive that now is growing rapidly and already contains over 15 Terabyte. Based on the concept of Astronomical Virtual Observatories (AVOs) , the use of archival data sets is on the rise and provides a large number of scientists with excellent opportunities for front-line investigations without having to wait for precious observing time. In addition to presenting a magnificent astronomical photo, the present account also illustrates this important new tool of the modern science of astronomy and astrophysics. PR Photo 18a/02 : WFI colour image of spiral galaxy NGC 300 (full field) . PR Photo 18b/02 : Cepheid stars in NGC 300 PR Photo 18c/02 : H-alpha image of NGC 300 PR Photo 18d/02 : Distant cluster of galaxies CL0053-37 in the NGC 300 field PR Photo 18e/02 : Dark matter distribution in CL0053-37 PR Photo 18f/02 : Distant, reddened cluster of galaxies in the NGC 300 field PR Photo 18g/02 : Distant galaxies, seen through the outskirts of NGC 300 PR Photo 18h/02 : "The View Beyond" ESO PR Photo 18a/02 ESO PR Photo 18a/02 [Preview - JPEG: 400 x 412 pix - 112k] [Normal - JPEG: 1200 x 1237 pix - 1.7M] [Hi-Res - JPEG: 4000 x 4123 pix - 20.3M] Caption : PR Photo 18a/02 is a reproduction of a colour-composite image of the nearby spiral galaxy

La préservation, atout essentiel pour contrer la précarité des ...

International Development Research Centre (IDRC) Digital Library (Canada)

La préservation, atout essentiel pour contrer la précarité des moyens de subsistance en ... Union mondiale pour la conservation de la nature et des ressources ... la recherche menée dans les domaines des sciences sociales, des sciences ...

Bruken av nasjonale prøver

DEFF Research Database (Denmark)

Skov, Poul

2010-01-01

Artiklen beskriver resultater fra en omfattende evaluering af brugen af de nationale prøver i norsk grundskole. De nationale prøver er blevet modtaget positivt af mange kommuner og skoleledere og i mindre grad af lærerne. Resultaterne viser også, at prøverne er styrende for undervisningen, at bru...

PrP(ST), a soluble, protease resistant and truncated PrP form features in the pathogenesis of a genetic prion disease.

Science.gov (United States)

Friedman-Levi, Yael; Mizrahi, Michal; Frid, Kati; Binyamin, Orli; Gabizon, Ruth

2013-01-01

While the conversion of PrP(C) into PrP(Sc) in the transmissible form of prion disease requires a preexisting PrP(Sc) seed, in genetic prion disease accumulation of disease related PrP could be associated with biochemical and metabolic modifications resulting from the designated PrP mutation. To investigate this possibility, we looked into the time related changes of PrP proteins in the brains of TgMHu2ME199K/wt mice, a line modeling for heterozygous genetic prion disease linked to the E200K PrP mutation. We found that while oligomeric entities of mutant E199KPrP exist at all ages, aggregates of wt PrP in the same brains presented only in advanced disease, indicating a late onset conversion process. We also show that most PK resistant PrP in TgMHu2ME199K mice is soluble and truncated (PrP(ST)), a pathogenic form never before associated with prion disease. We next looked into brain samples from E200K patients and found that both PK resistant PrPs, PrP(ST) as in TgMHu2ME199K mice, and "classical" PrP(Sc) as in infectious prion diseases, coincide in the patient's post mortem brains. We hypothesize that aberrant metabolism of mutant PrPs may result in the formation of previously unknown forms of the prion protein and that these may be central for the fatal outcome of the genetic prion condition.

PrP(ST, a soluble, protease resistant and truncated PrP form features in the pathogenesis of a genetic prion disease.

Directory of Open Access Journals (Sweden)

Yael Friedman-Levi

Full Text Available While the conversion of PrP(C into PrP(Sc in the transmissible form of prion disease requires a preexisting PrP(Sc seed, in genetic prion disease accumulation of disease related PrP could be associated with biochemical and metabolic modifications resulting from the designated PrP mutation. To investigate this possibility, we looked into the time related changes of PrP proteins in the brains of TgMHu2ME199K/wt mice, a line modeling for heterozygous genetic prion disease linked to the E200K PrP mutation. We found that while oligomeric entities of mutant E199KPrP exist at all ages, aggregates of wt PrP in the same brains presented only in advanced disease, indicating a late onset conversion process. We also show that most PK resistant PrP in TgMHu2ME199K mice is soluble and truncated (PrP(ST, a pathogenic form never before associated with prion disease. We next looked into brain samples from E200K patients and found that both PK resistant PrPs, PrP(ST as in TgMHu2ME199K mice, and "classical" PrP(Sc as in infectious prion diseases, coincide in the patient's post mortem brains. We hypothesize that aberrant metabolism of mutant PrPs may result in the formation of previously unknown forms of the prion protein and that these may be central for the fatal outcome of the genetic prion condition.

Lessons learned from the experiences of informal PrEP users in France: results from the ANRS-PrEPage study.

Science.gov (United States)

Rivierez, I; Quatremere, G; Spire, B; Ghosn, J; Rojas Castro, D

2018-05-30

Before January 2016, Pre-Exposure Prophylaxis (PrEP), a new biomedical HIV-prevention tool, was only available in France via ANRS-Ipergay clinical study but informal use was reported outside this setting. PrEPage qualitative study reports profiles and experiences of participants who used PrEP outside of a biomedical trial before this prevention method was authorized. Between March 2015 and February 2016, a cross-section of twenty-four informal PrEP users, mostly MSM, was recruited to complete in-depth semi-structured interviews. While ANRS-Ipergay was still ongoing (2012-2016), participants described their initiation to PrEP, the way they used it and the difficulties they faced to acquire antiretroviral drugs in an environment where PrEP was still not widely known and often criticized . Through the testimonies, different user profiles and motivation toward informal PrEP use emerged: (a) participants who have increasing difficulties using condoms, (b) "opportunists" who tried PrEP without the intention of using it regularly and (c) participants with a risk aversion who sought additional protection against HIV. Participants chose to use PrEP and/or their usual prevention strategies depending on available supplies, type of partners and individual attitudes toward risk. The feeling of living a safer sex life helped participants to outweigh the fear of possible toxicity and drug resistance. Participants' needs and expectations about PrEP implementation in France were also presented.

Computerbasiert prüfen [Computer-based Assessment

Directory of Open Access Journals (Sweden)

Frey, Peter

2006-08-01

Full Text Available [english] Computer-based testing in medical education offers new perspectives. Advantages are sequential or adaptive testing, integration of movies or sound, rapid feedback to candidates and management of web-based question banks. Computer-based testing can also be implemented in an OSCE examination. In e-learning environments formative self-assessment are often implemented and gives helpful feedbacks to learners. Disadvantages in high-stake exams are the high requirements as well for the quality of testing (e.g. standard setting as additionally for the information technology and especially for security. [german] Computerbasierte Prüfungen im Medizinstudium eröffnen neue Möglichkeiten. Vorteile solcher Prüfungen liegen im sequentiellen oder adaptiven Prüfen, in der Integration von Bewegtbildern oder Ton, der raschen Auswertung und zentraler Verwaltung der Prüfungsfragen via Internet. Ein Einsatzgebiet mit vertretbarem Aufwand sind Prüfungen mit mehreren Stationen wie beispielsweise die OSCE-Prüfung. Computerbasierte formative Selbsttests werden im Bereiche e-learning häufig angeboten. Das hilft den Lernenden ihren Wissensstand besser einzuschätzen oder sich mit den Leistungen anderer zu vergleichen. Grenzen zeigen sich bei den summativen Prüfungen beim Prüfungsort, da zuhause Betrug möglich ist. Höhere ärztliche Kompetenzen wie Untersuchungstechnik oder Kommunikation eigenen sich kaum für rechnergestützte Prüfungen.

On the PR-algebras

International Nuclear Information System (INIS)

Lebedenko, V.M.

1978-01-01

The PR-algebras, i.e. the Lie algebras with commutation relations of [Hsub(i),Hsub(j)]=rsub(ij)Hsub(i)(i< j) type are investigated. On the basis of former results a criterion for the membership of 2-solvable Lie algebras to the PR-algebra class is given. The conditions imposed by the criterion are formulated in the linear algebra language

Comet Tempel 1 Went Back to Sleep

Science.gov (United States)

2005-07-01

Astronomers Having Used ESO Telescopes Start Analysing Unique Dataset on the Comet Following the Deep Impact Mission Ten days after part of the Deep Impact spacecraft plunged onto Comet Tempel 1 with the aim to create a crater and expose pristine material from beneath the surface, astronomers are back in the ESO Offices in Santiago, after more than a week of observing at the ESO La Silla Paranal Observatory. In this unprecedented observing campaign - among the most ambitious ever conducted by a single observatory - the astronomers have collected a large amount of invaluable data on this comet. The astronomers have now started the lengthy process of data reduction and analysis. Being all together in a single place, and in close contacts with the space mission' scientific team, they will try to assemble a clear picture of the comet and of the impact. The ESO observations were part of a worldwide campaign to observe this unique experiment. During the campaign, ESO was connected by phone, email, and videoconference with colleagues in all major observatories worldwide, and data were freely exchanged between the different groups. This unique collaborative spirit provides astronomers with data taken almost around the clock during several days and this, with the largest variety of instruments, making the Deep Impact observing campaign one of the most successful of its kind, and thereby, ensuring the greatest scientific outcome. From the current analysis, it appears most likely that the impactor did not create a large new zone of activity and may have failed to liberate a large quantity of pristine material from beneath the surface. ESO PR Photo 22/05 ESO PR Photo 22/05 Evolution of Comet Tempel 1 (FORS2/VLT) [Preview - JPEG: 400 x 701 pix - 128k] [Normal - JPEG: 800 x 1401 pix - 357k] ESO PR Photo 22/05 Animated Gif Caption: ESO PR Photo 22/05 shows the evolution of Comet Tempel 1 as observed with the FORS2 instrument on Antu (VLT). The images obtained at the VLT show that

PrP aggregation can be seeded by pre-formed recombinant PrP amyloid fibrils without the replication of infectious prions.

Science.gov (United States)

Barron, Rona M; King, Declan; Jeffrey, Martin; McGovern, Gillian; Agarwal, Sonya; Gill, Andrew C; Piccardo, Pedro

2016-10-01

Mammalian prions are unusual infectious agents, as they are thought to consist solely of aggregates of misfolded prion protein (PrP). Generation of synthetic prions, composed of recombinant PrP (recPrP) refolded into fibrils, has been utilised to address whether PrP aggregates are, indeed, infectious prions. In several reports, neurological disease similar to transmissible spongiform encephalopathy (TSE) has been described following inoculation and passage of various forms of fibrils in transgenic mice and hamsters. However, in studies described here, we show that inoculation of recPrP fibrils does not cause TSE disease, but, instead, seeds the formation of PrP amyloid plaques in PrP-P101L knock-in transgenic mice (101LL). Importantly, both WT-recPrP fibrils and 101L-recPrP fibrils can seed plaque formation, indicating that the fibrillar conformation, and not the primary sequence of PrP in the inoculum, is important in initiating seeding. No replication of infectious prions or TSE disease was observed following both primary inoculation and subsequent subpassage. These data, therefore, argue against recPrP fibrils being infectious prions and, instead, indicate that these pre-formed seeds are acting to accelerate the formation of PrP amyloid plaques in 101LL Tg mice. In addition, these data reproduce a phenotype which was previously observed in 101LL mice following inoculation with brain extract containing in vivo-generated PrP amyloid fibrils, which has not been shown for other synthetic prion models. These data are reminiscent of the "prion-like" spread of aggregated forms of the beta-amyloid peptide (Aβ), α-synuclein and tau observed following inoculation of transgenic mice with pre-formed seeds of each misfolded protein. Hence, even when the protein is PrP, misfolding and aggregation do not reproduce the full clinicopathological phenotype of disease. The initiation and spread of protein aggregation in transgenic mouse lines following inoculation with pre

Growth and scintillation properties of Pr doped YAP with different Pr concentrations

International Nuclear Information System (INIS)

Yanagida, Takayuki; Kamada, Kei; Fujimoto, Yutaka; Sugiyama, Makoto; Furuya, Yuki; Yamaji, Akihiro; Yokota, Yuui; Yoshikawa, Akira

2010-01-01

Pr 3+ 0.2, 0.75, and 3 mol% doped YAP single crystalline scintillators were grown by using the micro-pulling down (μ-PD) method. Pr 3+ 0.05 mol% doped YAP was also prepared by using the Czochralski method. In transmittance spectra, 4f-5d absorption line appeared at 230 nm. The μ-PD grown crystals showed intense emission at 290 nm while the Czochralski grown one showed an emission peak at 245 nm in radio luminescence spectra under X-ray excitation. Among them, the Czochralski grown one exhibited the highest light yield under 137 Cs 662 keV excitation and the absolute light yield of this sample was estimated to be 20400±2000 ph/MeV. The decay time constants of these scintillators were around 10 ns due to Pr 3+ 5d-4f transition.

Growth and scintillation properties of Pr doped YAP with different Pr concentrations

Energy Technology Data Exchange (ETDEWEB)

Yanagida, Takayuki, E-mail: t_yanagi@tagen.tohoku.ac.j [Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577 (Japan); Kamada, Kei; Fujimoto, Yutaka; Sugiyama, Makoto; Furuya, Yuki [Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577 (Japan); Yamaji, Akihiro [New Industry Creation Hatchery Center (NICHe), Tohoku University, 6-6-10 Aoba, Aramaki, Aoba-ku, Sendai 980-8579 (Japan); Yokota, Yuui [Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577 (Japan); Yoshikawa, Akira [Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577 (Japan); New Industry Creation Hatchery Center (NICHe), Tohoku University, 6-6-10 Aoba, Aramaki, Aoba-ku, Sendai 980-8579 (Japan)

2010-11-21

Pr{sup 3+} 0.2, 0.75, and 3 mol% doped YAP single crystalline scintillators were grown by using the micro-pulling down ({mu}-PD) method. Pr{sup 3+} 0.05 mol% doped YAP was also prepared by using the Czochralski method. In transmittance spectra, 4f-5d absorption line appeared at 230 nm. The {mu}-PD grown crystals showed intense emission at 290 nm while the Czochralski grown one showed an emission peak at 245 nm in radio luminescence spectra under X-ray excitation. Among them, the Czochralski grown one exhibited the highest light yield under {sup 137}Cs 662 keV excitation and the absolute light yield of this sample was estimated to be 20400{+-}2000 ph/MeV. The decay time constants of these scintillators were around 10 ns due to Pr{sup 3+} 5d-4f transition.

Infrared and optical light curves of EX Hydrae and VW Hydri

International Nuclear Information System (INIS)

Sherrington, M.R.; Lawson, P.A.; King, A.R.; Jameson, R.F.

1980-01-01

Optical and infrared light curves of EX Hya (V and K) and VW Hyi (J and K) are presented. The infrared colours imply very large discs for these systems. It is also found for EX Hya that the structure of the light curves is non-repeatable. (author)

Magnetic properties of Pr ions in perovskite-type oxides

International Nuclear Information System (INIS)

Sekizawa, K.; Kitagawa, M.; Takano, Y.

1998-01-01

Magnetic properties of Pr ions with the controlled valence on the A and B sites of perovskite-type oxides (ABO 3 ) were investigated for two systems. PrSc 1-x Mg x O 3 and BaPr 1-x Bi x O 3 . From the magnetic susceptibility χ versus temperature T curves of PrSc 1-x Mg x O 3 , the χ-T curve for molar Pr 3+ ions on the A site and that of Pr 4+ ions were obtained. The 1/χ-T curves for both ions exhibit the crystalline electric field (CEF) effect and the effective magneticmoment μ eff above 100 K is 3.41 μ B for Pr 3- and 2.58 μ B for Pr 4+ , respectively. The χ-T curve of PrSc 0.8 Mg 0.2 O 3 is similar to that of PrBa 2 Cu 3 O y . In the BaPr 1-x Bi x O 3 system, only one intermediate phase BaPr 0.5 Bi 0.5 O 3 exists, in which Pr and Bi take an ordered arrangement on the B site. The magnetic susceptibility χ for Pr 4+ and that of Pr 3+ in the ordered arrangement with Bi 5- on the B site are much smaller than those for the A site, reflecting the strong CEF effect on the B site. Experimental χ-T curves can be well reproducedby the numerical calculation for Pr 3+ or Pr 4+ ions in the molecular field and the CEF with proper respective parameters. (orig.)

Prévalence, facteurs associés et prédisposant au syndrome ...

African Journals Online (AJOL)

Introduction: Le syndrome métabolique est associé aux maladies cardiovasculaires. L'infection au VIH est devenue aujourd'hui une maladie chronique. L'objectif de cette étude est de déterminer la prévalence, les facteurs associés et prédisposant au syndrome métabolique chez les patients infectés par le VIH sous ...

Aspects of Pr3+ luminescence in solids

International Nuclear Information System (INIS)

Srivastava, A.M.

2016-01-01

A brief perspective on the influence of “host lattice-Pr 3+ ” interactions on the optical properties of the Pr 3+ ion in solids is presented. How the energy position of the Pr 3+ 4f 1 5d 1 configuration relative to the 1 S 0 , 3 P J and host lattice conduction band levels influences the Pr 3+ optical properties is highlighted by considering solids in which the 4f 1 5d 1 configuration (1) is energetically above the 1 S 0 level, (2) is energetically below the 1 S 0 level, (3) is energetically close to the 1 S 0 level, and (4) overlaps with the host lattice conduction band. - Highlights: • Spectroscopic properties of Pr 3+ in solids is examined. • The influence of Pr 3+ 4f 1 5d 1 energy position relative to the 4f 2 levels is discussed. • The effect of interaction between Pr 3+ 4f 1 5d 1 and host conduction level is illustrated. • The paper identifies potential commercial applications.

First Light with a 67-Million-Pixel WFI Camera

Science.gov (United States)

1999-01-01

tests with the WFI in order to arrive at the optimum adjustment of the camera at the telescope. We show here two of these that illustrate the great potential of this new facility. Spiral Galaxy NGC 253 ESO PR Photo 02a/99 ESO PR Photo 02a/99 [Preview - JPEG: 800x850 pix - 205k] [High-Res - JPEG: 4000 x 4252 pix - 3.0Mb] ESO PR Photo 02b/99 ESO PR Photo 02b/99 [Preview - JPEG: 800x870 pix - 353k] [High-Res - JPEG: 2200 x 2393 pix - 2.0Mb] Caption to PR Photos 02a/99 and 02b/99 : These photos show a sky field around the Spiral Galaxy NGC 253 (Type Sc) seen nearly edge-on. It is located in the southern constellation Sculptor at a distance of about 8 million light-years. The image is the sum of five 5-min exposures through a blue (B-band) optical filtre. They were slightly offset with respect to each other so that the small gaps between the eight CCD's of the mosaic are no longer visible. This image also shows the faint trails of 2 artificial satellites. In PR Photo 02a/99 , the full WFI field-of-view is reproduced, while the sub-field in PR Photo 02b/99 contains some fainter and smaller background galaxies. Many of the quite numerous and small, slightly fuzzy objects are undoubtedly globular clusters of NGC 253. Technical information: The image processing consisted of de-biassing, flat-fielding, and removal (by interpolation) of some bad columns. The full-width-half-maximum (FWHM) of stellar images is about 1.0 arcsec. PR Photo 02a/99 was rebinned (2x2) to 4kx4k size and sampling 0.48 arcsec/pixel. PR Photo 02b/99 is a subimage of the former, but at the full original sampling of 0.24 arcsec/pixel. It covers about 2kx2k, or about 1/16 of the full field. North is up and East is left. The observations were made on December 17, 1998. The Waning Moon ESO PR Photo 02c/99 ESO PR Photo 02c/99 [Preview - JPEG: 800 x 1245 pix - 242k] [High-Res - JPEG: 3000 x 4667 pix - 2.3Mb] ESO PR Photo 02d/99 ESO PR Photo 02d/99 [Preview - JPEG: 800 x 1003 pix - 394k] [High-Res - JPEG: 3000 x

Exotic behaviours in the Pr-based filled skutterudites

International Nuclear Information System (INIS)

Sato, H; Sugawara, H; Namiki, T; Saha, S R; Osaki, S; Matsuda, T D; Aoki, Y; Inada, Y; Shishido, H; Settai, R; Onuki, Y

2003-01-01

The exotic features of the Pr-based filled skutterudites are reviewed based on the electronic transport properties, specific heat and de Haas-van Alphen experiments, putting the emphasis on PrFe 4 P 12 and PrOs 4 Sb 12 . As references, the experiments on the related La- and Ce-filled skutterudites are also examined and discussed. Compared to their La reference compounds, the Fermi surface is very similar in PrOs 4 Sb 12 , suggesting the well localized character of 4f electrons, while it looks largely different in PrFe 4 P 12 . For the cyclotron effective mass, both PrFe 4 P 12 and PrOs 4 Sb 12 exhibit a strong enhancement, in reasonable agreement with the large specific heat coefficient

Competency profile of PR professional in sport

OpenAIRE

Gazdíková, Lenka

2013-01-01

Title: Competency profile of PR professional in sport Objective: The objective is to identify competencies required to a position of PR professional in sport. The aim of a survey is to verify the level of competencies which follows compiling competency profile and comparison with existing profile of PR specialist. Methods: The objective is achieved using survey, interview and analysis of competency models database. Results: The result of this paper is competency profile of PR professional in ...

Digitale prøver – et litteraturstudie

Directory of Open Access Journals (Sweden)

Karen Louise Møller

2015-10-01

Full Text Available Digitale prøveformer bliver efterhånden mere og mere udbredte. Denne artikel er baseret på et litteraturstudie foretaget for at få indsigt i primært forskningslitteraturen om digitale prøveformer. I artiklen præsenterer vi de forskellige typer digitale prøver, der omtales og diskuteres i litteraturen, og vi beskriver de potentielle fordele af bl.a. økonomisk, administrativ og pædagogisk karakter, der ifølge litteraturen kan opnås ved at bruge digitale prøver. Vi beskriver endvidere de udfordringer og potentielle ulemper, der kan være forbundet med indførelse af digitale prøver. Det drejer sig bl.a. om udfordringer hvad angår prøvesystem, organisation, teknologi, kompetenceudvikling og uddannelseskultur. Vi beskriver i artiklen en række konkrete eksempler på digitale prøver, og vi præsenterer resultater fra undersøgelser af underviseres og studerendes oplevelser med digitale prøveformer. Against the backdrop of the rapid spread of digitized tests and exams, this article sets out to present some of the results of a literature study carried out with the aim of gaining insight into the research literature on this topic. The article presents different types of tests, focusing on the financial, administrative, and pedagogical advantages described and discussed in the literature as potentially attainable through the use of digitized exams. In addition, the challenges and potential problems connected with the introduction of digitized tests are described. Among these are challenges related to the test system or to competence development as well as organizational, technological, and cultural challenges. Finally, the article provides concrete descriptions of tests and presents results from select studies of teacher and student experiences of digitized tests.

Magnetic and thermodynamic properties of the Pr-based ferromagnet PrGe2-δ

Science.gov (United States)

Matsumoto, Keisuke T.; Morioka, Naoya; Hiraoka, Koichi

2018-03-01

We investigated the magnetization, M, and specific heat, C, of ThSi2-type PrGe2-δ. A polycrystalline sample of PrGe2-δ was prepared by arc-melting. Magnetization divided by magnetic field, M / B, increased sharply and C showed a clear jump at the Curie temperature, TC, of 14.6 K; these results indicate that PrGe2-δ ordered ferromagnetically. The magnetic entropy at TC reached R ln 3, indicating a quasi-triplet crystalline electric field (CEF) ground state. The maximum value of magnetic entropy change was 11.5 J/K kg with a field change of 7 T, which is comparable to those of other right rare-earth based magnetocaloric materials. This large magnetic entropy change was attributed to the quasi-triplet ground state of the CEF.

Microstructure and martensitic transformation of Ni-Ti-Pr alloys

Energy Technology Data Exchange (ETDEWEB)

Zhao, Chunwang [Inner Mongolia University of Technology, College of Science, Hohhot (China); Shanghai Maritime University, College of Arts and Sciences, Shanghai (China); Zhao, Shilei; Jin, Yongjun; Hou, Qingyu [Inner Mongolia University of Technology, College of Science, Hohhot (China); Guo, Shaoqiang [Beihang University, Key Laboratory of Micro-nano Measurement, Manipulation and Physics (Ministry of Education), Department of Physics, Beijing (China)

2017-09-15

The effect of Pr addition on the microstructure and martensitic transformation behavior of Ni{sub 50}Ti{sub 50-x}Pr{sub x} (x = 0, 0.1, 0.3, 0.5, 0.7, 0.9) alloys were investigated experimentally. Results show that the microstructures of Ni-Ti-Pr alloys consist of the NiTi matrix and the NiPr precipitate with the Ti solute. The martensitic transformation start temperature decreases gradually with the increase in Pr fraction. The stress around NiPr precipitates is responsible for the decrease in martensitic transformation temperature with the increase in Pr fraction in Ni-Ti-Pr alloys. (orig.)

The PR Officer's Survival Kit.

Science.gov (United States)

Woodrum, Robert L.

1996-01-01

A former corporate public relations (PR) professional shares strategies for communicating and cooperating with the chief executive officer, and particularly for coping with differences in perceptions of the public relations officer's role. Basic attributes of a successful PR professional are outlined: good communication skills, an analytical…

Distant World in Peril Discovered from La Silla

Science.gov (United States)

2003-01-01

Giant Exoplanet Orbits Giant Star Summary When, in a distant future, the Sun begins to expand and evolves into a "giant" star, the surface temperature on the Earth will rise dramatically and our home planet will eventually be incinerated by that central body. Fortunately for us, this dramatic event is several billion years away. However, that sad fate will befall another planet, just discovered in orbit about the giant star HD 47536, already within a few tens of millions of years. At a distance of nearly 400 light-years from us, it is the second-remotest planetary system discovered to date [1]. This is an interesting side-result of a major research project, now carried out by a European-Brazilian team of astronomers [2]. In the course of a three-year spectroscopic survey, they have observed about 80 giant stars in the southern sky with the advanced FEROS spectrograph on the 1.52-m telescope installed at the ESO La Silla Observatory (Chile). It is one of these stars that has just been found to host a giant planet. This is only the fourth such case known and with a diameter of about 33 million km (or 23.5 times that of our Sun), HD 47536 is by far the largest of those giant stars [1]. The distance of the planet from the star is still of the order of 300 million km (or twice the distance of the Earth from the Sun), a safe margin now, but this will not always be so. The orbital period is 712 days, i.e., somewhat less than two Earth years, and the planet's mass is 5 - 10 times that of Jupiter. The presence of exoplanets in orbit around giant stars, some of which will eventually perish into their central star (be "cannibalized"), provides a possible explanation of the anomalous abundance of certain chemical elements that is observed in the atmospheres of some stars, cf. ESO PR 10/01. This interesting discovery bodes well for coming observations of exoplanetary systems with new, more powerful instruments, like HARPS to be installed next year at the ESO 3.6-m telescope on

Praseodymium valency from crystal structure in Pr-Ba-Cu-O and (Y-Pr)-Ba-Cu-O single crystals

International Nuclear Information System (INIS)

Collin, G.; Albouy, P.A.; Monod, P.; Ribault, M.

1990-01-01

The substitution of Pr to Y leads to materials with a general formula (Y 1-v Pr v ) (Ba 2-x Pr x ) (Cu 3-y vac y ) O 6+x/2-y+z and with a structural transition around v + x' ∼ 0.5. For v + x 0.5 the crystals are tetragonal, La 1.5 Ba 1.5 Cu 3 O 7±z type, with the characteristic tri-twinning of this phase. The Pr valency, in the range 3-3.2 + depending on preparation conditions, is determined from interatomic distances. Orthorhombic crystals of Pr Ba Cu O prepared at high temperatures exhibit a high amount of defects, y ∼ 0.25 on the Cu(1) site and are semiconductors with a T -1/4 activation law attributed to the praseodymium valence fluctuation

Prática de ensino supervisionada em educação pré-escolar

OpenAIRE

Patrício, Linda Cristel

2017-01-01

O presente relatório de estágio desenvolveu-se no âmbito da Prática de Ensino Supervisionada, tendo por finalidade a obtenção do grau de mestre em Educação Pré-Escolar. A prática educativa foi desenvolvida em contexto de Creche e Jardim-de-Infância e a temática que me mereceu particular reflexão foi o desenvolvimento motor, no sentido de saber que oportunidades neste âmbito, são proporcionadas às crianças. Considerando a educação física como um domínio enquadrado nas Orientações Curricular...

Prevalência de aleitamento materno e fatores associados no município de Londrina-PR Prevalencia de lactancia materna y factores asociados en el municipio de Londrina-PR Prevalence of breastfeeding and associated factors in the municipality of Londrina (PR, Brazil

Directory of Open Access Journals (Sweden)

Sarah Nancy Deggau Hegeto de Souza

2012-01-01

Full Text Available OBJETIVO: Descrever a prevalência do aleitamento materno e fatores associados no município de Londrina-PR. MÉTODOS: Estudo quantitativo, descritivo, entrevistando 770 acompanhantes de crianças menores de 12 meses, durante a campanha de vacinação antipoliomielite, em agosto de 2008. RESULTADOS: Na primeira hora, foram amamentadas 72,5% das crianças; 33,8% estavam em aleitamento materno exclusivo de zero a seis meses, no quarto mês, 53,7% e no sexto mês 7,8%; 51,5% em aleitamento materno continuado entre 9 e 12 meses. As mulheres que mais amamentaram tinham idade igual ou superior a 35 anos, escolaridade de terceiro grau, mais de um filho e estavam em licença-maternidade. CONCLUSÃO: os índices de aleitamento materno do município apresentaram evolução, porém faz-se necessário analisar as ações nos serviços de saúde para melhora desses índices.OBJETIVO: Describir la prevalencia de la lactancia materna y factores asociados en el municipio de Londrina-PR. MÉTODOS: Estudio cuantitativo, descriptivo, realizado con la entrevista a 770 acompañantes de niños menores de 12 meses, durante la campaña de vacunación antipoliomielítica, en agosto del 2008. RESULTADOS: En la primera hora, fueron amamantadas el 72,5% de los niños; el 33,8% estaban con lactancia materna exclusiva de cero a seis meses, en el cuarto mes, el 53,7% y en el sexto mes el 7,8%; el 1,5% en lactancia materna continuada entre 9 y 12 meses. Las mujeres que más amamantaron tenían edad igual o superior a 35 años, escolaridad de tercer grado, más de un hijo y estaban con licencia-maternidad. CONCLUSIÓN: los índices de lactancia materna del municipio presentaron evolución, sin embargo se hace necesario analizar las acciones en los servicios de salud para mejorar esos índices.OBJECTIVE: To describe breastfeeding prevalence and associated factors, in the municipality of Londrina, PR, Brazil. METHODS: This quantitative, descriptive study included interviews of

Scintillation properties of μPD-grown Y{sub 4}Al{sub 2}O{sub 9}:Pr (YAM:Pr) crystals

Energy Technology Data Exchange (ETDEWEB)

Drozdowski, Winicjusz, E-mail: wind@fizyka.umk.pl [Institute of Physics, Faculty of Physics, Astronomy and Informatics, Nicolaus Copernicus University, Grudziadzka 5, 87-100 Torun (Poland); Brylew, Kamil [Institute of Physics, Faculty of Physics, Astronomy and Informatics, Nicolaus Copernicus University, Grudziadzka 5, 87-100 Torun (Poland); Malinowski, Michał [Institute of Microelectronics and Optoelectronics, Koszykowa 75, 00-662 Warsaw (Poland); Turczyński, Sebastian [Institute of Electronic Materials Technology, Wolczynska 133, 01-919 Warsaw (Poland)

2015-05-25

Highlights: • YAM:Pr crystals do scintillate and as such deserve further interest. • Fast d–f luminescence of Pr{sup 3+} ions appears in X-ray excited spectra. • Two components (24 and 790 ns) constitute scintillation time profiles. - Abstract: Y{sub 4}Al{sub 2}O{sub 9}:Pr (YAM:Pr) crystals have been grown by the micro-pulling-down method and their scintillation properties have been investigated. YAM:0.1%Pr displays a light yield of about 2000 ph/MeV and its scintillation time profile contains a prompt component with a decay time of 23.5 ns and a contribution of 20%. Radioluminescence spectra show both fast d–f and slow f–f praseodymium emissions. Low temperature glow curves are complex, consisting of discrete peaks and broad bands related to quasi-continuous trap distributions. Overall scintillation performance of YAM:Pr deteriorates with increasing praseodymium concentration.

Der Effekt von Akupunktur in der Prävention von Prüfungsangst

OpenAIRE

Krüger, Peter

2017-01-01

Prüfungsangst ist ein weit verbreitetes gesellschaftliches Phänomen, das bisher in nur wenigen wissenschaftlichen Ansätzen untersucht wurde. Die Zahl der Studenten, die Gehirn - Doping zur Leistungssteigerung und zur Minimierung von Prüfungsangst nutzen, steigt stetig an. In bisherigen Studien wurde Akupunktur an Herz 7 als vielversprechende Behandlungsalternative dargestellt. Basierend auf diesen Ergebnissen, wurde in dieser Arbeit untersucht, ob eine Einzelpunktakupunktur an Herz 7 die ...

PR's involvement in International Cooperation

NARCIS (Netherlands)

Anonymous,

1995-01-01

In The Netherlands, the Research Station for Cattle, Sheep and Horse Husbandry (in Dutch abbreviated as PR) bridges the gap between more basic and disciplinary research done at universities and research institutes on the one hand and the extension service and the farmers on the other hand. The PR

Discursos sobre juventude e práticas psicológicas: a produção dos modos de ser jovem. Brasil

Directory of Open Access Journals (Sweden)

Zuleika Köhler Gonzales

2008-01-01

Full Text Available La persona joven ha sido centro de atención por parte de las instituciones sociales, tanto públicas como privadas. En los discursos de la sociedad sobre esta población, el joven o la joven se asocia, actualmente, a la idea de inserción en los procesos sociales. En el campo académico, se percibe una importante producción de investigaciones y de conocimiento acerca de la juventud. En las producciones del conocimiento sobre la juventud circula un discurso de "preocupación" con relación a los jóvenes y a las jóvenes, en cuanto a su integración en el orden social, económico y familiar. En este artículo, se hace referencia a las concepciones de juventud que fueron legitimadas en diferentes momentos sociales y se pretende comprender cómo se ha visibilizado un determinado discurso sobre esta categoría, generalmente asociado a la noción de problema. En el proceso, se busca discutir las implicaciones de este discurso en las prácticas psicológicas e indagar cómo los jóvenes y las jóvenes están siendo afectados y afectadas por determinadas prácticas sociales contemporáneas, generando diversos modos de subjetivación, que al mismo tiempo son pensados, fomentados y resignificados en relaciones de poder y verdad, sustentadas por saberes como el psicológico. También se pretende evidenciar cómo esos sujetos han sido intervenidos por el mercado capitalista como consumidores y consumidoras en potencia.

Identification of PrP sequences essential for the interaction between the PrP polymers and Aβ peptide in a yeast-based assay

OpenAIRE

Rubel, Aleksandr A; Ryzhova, Tatyana A; Antonets, Kirill S; Chernoff, Yury O; Galkin, Alexey P

2013-01-01

Alzheimer disease is associated with the accumulation of oligomeric amyloid β peptide (Aβ), accompanied by synaptic dysfunction and neuronal death. Polymeric form of prion protein (PrP), PrPSc, is implicated in transmissible spongiform encephalopathies (TSEs). Recently, it was shown that the monomeric cellular form of PrP (PrPC), located on the neuron surface, binds Aβ oligomers (and possibly other β-rich conformers) via the PrP23–27 and PrP90–110 segments, acting as Aβ receptor. On the other...

75 FR 51531 - Proposed Collection; Comment Request for Forms 941, 941-PR, 941-SS, 941-X, 941-X(PR), Schedule B...

Science.gov (United States)

2010-08-20

... 941, 941-PR, 941- SS, 941-X, 941-X(PR), Schedule B (Form 941), Schedule R (Form 941) and Schedule B (Form 941-PR) AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice and request for comments... comments concerning Forms 941 (Employer's Quarterly Federal Tax Return), 941-PR (Planilla Para La...

78 FR 47056 - Proposed Collection; Comment Request for Forms 941, 941-PR, 941-SS, 941-X, 941-X(PR), Schedule B...

Science.gov (United States)

2013-08-02

... 941, 941-PR, 941- SS, 941-X, 941-X(PR), Schedule B (Form 941), Schedule R (Form 941)and Schedule B (Form 941-PR) AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice and request for comments... Forms 941 (Employer's Quarterly Federal Tax Return), 941-PR, 941-SS (Employer's Quarterly Federal Tax...

Magna Carta for Researchers

Science.gov (United States)

2006-12-01

Today, Janez Potočnik, European Commissioner for Science and Research received a statement of support for the European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers from EIROforum. "The EIROforum partners warmly welcome this valuable initiative by the European Commission", said Prof. William G. Stirling, Director General of ESRF and present Chairman of EIROforum."This is an important step towards the implementation of the European Research Area." ESO PR Photo 47/06 ESO PR Photo 47a/06 Janez Potočnik, European Commissioner for Science and Research receives the statement of support from Bill Stirling, Director General of ESRF and present Chairman of EIROforum. The European Charter for Researchers addresses the roles, responsibilities and entitlements of researchers and their employers or funding organisations. It aims at ensuring that the relationship between these parties contributes to successful performance in the generation, transfer and sharing of knowledge, and to the career development of researchers. The Code of Conduct for the Recruitment of Researchers aims to improve recruitment, to make selection procedures fairer and more transparent and proposes different means of judging merit. Merit should not just be measured on the number of publications but on a wider range of evaluation criteria, such as teaching, supervision, teamwork, knowledge transfer, management and public awareness activities. ESO PR Photo 47/06 ESO PR Photo 47b/06 The signature of the statement of support last November. From left to right: Richard Wagner, Director of the ILL, David Southwood, Scientific Director of ESA, Robert Aymar, Director General of CERN, Bill Stirling, Director General of ESRF, Catherine Cesarsky, Director General of ESO, Francesco Romanelli, EFDA-JET leader and Silke Schumacher, Coordinator International Relations and Communication of the EMBL. In their statement, signed at the EIROforum Assembly on 15 November 2006, the seven

Conditions promoting and restraining agronomic effectiveness of water-insoluble phosphate sources, in particular phosphate rock (PR): III. 32P-aided soil-PR interaction studies aimed at enhancing P bioavailability from PR

International Nuclear Information System (INIS)

Borlan, Z.; Soare, M.; Gavriluta, I.; Alexandrescu, A.; Stefanescu, D.

2002-01-01

Mobilization of PR and bioavailability of PR-P for plants takes place through complex chemical and biochemical processes that occurs during prolonged soil interaction with PR. There is a high probability that certain processes of a biochemical nature are also involved through proteinaceous ion carriers whose concentration and physiological activity in plant roots may be influenced by means of specially formulated foliar fertilizer compositions. 32 P-aided studies have contributed to identify possibilities of enhancing PR-P bioavailability through foliar fertilizer application. (author)

Cytosolic PrP Can Participate in Prion-Mediated Toxicity

Science.gov (United States)

Thackray, Alana M.; Zhang, Chang; Arndt, Tina

2014-01-01

ABSTRACT Prion diseases are characterized by a conformational change in the normal host protein PrPC. While the majority of mature PrPC is tethered to the plasma membrane by a glycosylphosphatidylinositol anchor, topological variants of this protein can arise during its biosynthesis. Here we have generated Drosophila transgenic for cytosolic ovine PrP in order to investigate its toxic potential in flies in the absence or presence of exogenous ovine prions. While cytosolic ovine PrP expressed in Drosophila was predominantly detergent insoluble and showed resistance to low concentrations of proteinase K, it was not overtly detrimental to the flies. However, Drosophila transgenic for cytosolic PrP expression exposed to classical or atypical scrapie prion inocula showed a faster decrease in locomotor activity than similar flies exposed to scrapie-free material. The susceptibility to classical scrapie inocula could be assessed in Drosophila transgenic for panneuronal expression of cytosolic PrP, whereas susceptibility to atypical scrapie required ubiquitous PrP expression. Significantly, the toxic phenotype induced by ovine scrapie in cytosolic PrP transgenic Drosophila was transmissible to recipient PrP transgenic flies. These data show that while cytosolic PrP expression does not adversely affect Drosophila, this topological PrP variant can participate in the generation of transmissible scrapie-induced toxicity. These observations also show that PrP transgenic Drosophila are susceptible to classical and atypical scrapie prion strains and highlight the utility of this invertebrate host as a model of mammalian prion disease. IMPORTANCE During prion diseases, the host protein PrPC converts into an abnormal conformer, PrPSc, a process coupled to the generation of transmissible prions and neurotoxicity. While PrPC is principally a glycosylphosphatidylinositol-anchored membrane protein, the role of topological variants, such as cytosolic PrP, in prion-mediated toxicity and

Home-based pre-exposure prophylaxis (PrEP services for gay and bisexual men: An opportunity to address barriers to PrEP uptake and persistence.

Directory of Open Access Journals (Sweden)

Steven A John

Full Text Available Gay, bisexual, and other men who have sex with men (GBM are disproportionately affected by the HIV epidemic. Despite the promise of pre-exposure prophylaxis (PrEP in reducing HIV transmission risk, barriers for uptake and persistence exist. We sought to identify whether GBM in a nationwide cohort who have not yet initiated PrEP (n = 906 would prefer to get PrEP-related care from a primary care provider (PCP compared to a specialist clinic or provider. We then sought to identify their level of interest and factors associated with preference for using home-based PrEP services (i.e., HB-PrEP, defined to participants as conducting HIV/STI self-testing from home with PrEP prescription mailing after an initial in-person clinic visit. We examined the associations of demographics, sexual HIV transmission risk, concern about frequent medical checkups associated with PrEP, health care access, and PrEP intentions with preferences for healthcare provider type and HB-PrEP. Concern about frequent medical checkups were associated with preferring a PCP for PrEP-related care, but men who perceived a barrier to bringing up the topic of PrEP with a doctor preferred a specialist clinic or provider more than a PCP. HB-PrEP was more appealing for younger men and those engaged in sexual HIV transmission risk, suggesting HB-PrEP could help reach GBM most vulnerable to HIV and in need of PrEP. HB-PrEP expansion has potential to increase PrEP uptake and persistence among GBM, particularly for men with barriers to clinic-based care and higher intentions to initiate PrEP. Clinical guidelines regarding HB-PrEP are needed to expand its use.

Jurnalistikadan gələn PR-çı

OpenAIRE

Mənsimi, Cəfər; Soltan, Arzu (editör)

2017-01-01

Azerbaycan'da ilk online PR derggisi olan PRoloq.az'da PR uzmanı ve "PR labarotoriya"nın başkanı Afet Yaqubova ile röportaj. PR mütəxəssisi və PR laboratoriyanın direktoru Afət Yaqubova ilə müsahibə,

Thermodynamic database for the Co-Pr system

Directory of Open Access Journals (Sweden)

S.H. Zhou

2016-03-01

Full Text Available In this article, we describe data on (1 compositions for both as-cast and heat treated specimens were summarized in Table 1; (2 the determined enthalpy of mixing of liquid phase is listed in Table 2; (3 thermodynamic database of the Co-Pr system in TDB format for the research articled entitle Chemical partitioning for the Co-Pr system: First-principles, experiments and energetic calculations to investigate the hard magnetic phase W. Keywords: Thermodynamic database of Co-Pr, Solution calorimeter measurement, Phase diagram Co-Pr

Prácticas curriculares

OpenAIRE

García-Gordillo, Mar; Checa Godoy, Antonio; Gómez Mompart, Josep Lluis (Coordinador); Herrero Subías, Mónica (Coordinador)

2015-01-01

Esta ponencia pretende analizar, sucintamente, la situacion presente de las prácticas externas en las facultades de Comunicacion españolas. En una coyuntura sumamente peculiar, no solo para las prácticas de los titulos de Comunicacion, sino para todas las practicas universitarias, por los numerosos y a veces contradictorios cambios acaecidos en la legislacion reciente y los vaivenes normativos de las universidades; por la profunda crisis que viene atravesando el sector de la...

The 0.5-2.22 micrometer Scattered Light Spectrum of the Disk around TW Hya: Detection of a Partially Filled Disk Gap at 80 AU*

Science.gov (United States)

Debes, John H.; Jang-Condell, Hannah; Weinberger, Alycia J.; Roberge, Aki; Schneider, Glenn

2013-01-01

We present a 0.5-2.2 micrometer scattered light spectrum of the circumstellar disk around TW Hya from a combination of spatially resolved Hubble Space Telescope STIS spectroscopy and NICMOS coronagraphic images of the disk. We investigate the morphology of the disk at distances greater than 40 AU over this wide range of wavelengths, and identify the presence of a depression in surface brightness at approximately 80 AU that could be caused by a gap in the disk. Additionally, we quantify the surface brightness, azimuthal symmetry, and spectral character of the disk as a function of radius. Our analysis shows that the scattering efficiency of the dust is largely neutral to blue over the observed wavelengths. We model the disk as a steady a-disk with an ad hoc gap structure. The thermal properties of the disk are selfconsistently calculated using a three-dimensional radiative transfer code that uses ray tracing to model the heating of the disk interior and scattered light images. We find a good fit to the data over a wide range of distances from the star if we use a model disk with a partially filled gap of 30% depth at 80 AU and with a self-similar truncation knee at 100 AU. The origin of the gap is unclear, but it could arise from a transition in the nature of the disk's dust composition or the presence of a planetary companion. Based on scalings to previous hydrodynamic simulations of gap-opening criteria for embedded proto-planets, we estimate that a planetary companion forming the gap could have a mass between 6 and 28 solar mass.

New Fast Lane towards Discoveries of Clusters of Galaxies Inaugurated

Science.gov (United States)

2003-07-01

Space and Ground-Based Telescopes Cooperate to Gain Deep Cosmological Insights Summary Using the ESA XMM-Newton satellite, a team of European and Chilean astronomers [2] has obtained the world's deepest "wide-field" X-ray image of the cosmos to date. This penetrating view, when complemented with observations by some of the largest and most efficient ground-based optical telescopes, including the ESO Very Large Telescope (VLT), has resulted in the discovery of several large clusters of galaxies. These early results from an ambitious research programme are extremely promising and pave the way for a very comprehensive and thorough census of clusters of galaxies at various epochs. Relying on the foremost astronomical technology and with an unequalled observational efficiency, this project is set to provide new insights into the structure and evolution of the distant Universe. PR Photo 19a/03: First image from the XMM-LSS survey. PR Photo 19b/03: Zoom-in on PR Photo 19b/03. PR Photo 19c/03: XMM-Newton contour map of the probable extent of a cluster of galaxies, superimposed upon a CHFT I-band image. PR Photo 19d/03: Velocity distribution in the cluster field shown in PR Photo 19c/03. The universal web Unlike grains of sand on a beach, matter is not uniformly spread throughout the Universe. Instead, it is concentrated into galaxies which themselves congregate into clusters (and even clusters of clusters). These clusters are "strung" throughout the Universe in a web-like structure, cf. ESO PR 11/01. Our Galaxy, the Milky Way, for example, belongs to the so-called Local Group which also comprises "Messier 31", the Andromeda Galaxy. The Local Group contains about 30 galaxies and measures a few million light-years across. Other clusters are much larger. The Coma cluster contains thousands of galaxies and measures more than 20 million light-years. Another well known example is the Virgo cluster, covering no less than 10 degrees on the sky ! Clusters of galaxies are the most

Luminescence dependence of Pr3+ activated SiO2 nanophosphor on Pr3+ concentration, temperature, and ZnO incorporation

CSIR Research Space (South Africa)

Mhlongo, GH

2011-08-01

Full Text Available Green-emitting ZnO nanoparticles were successfully embedded in Pr3+-doped SiO2 by a sol–gel method resulting in a red-emitting ZnO·SiO2:Pr3+ nanocomposite phosphor. The particle morphology and luminescent properties of SiO2:Pr3+ phosphor powders...

Electronic structures of PrBa2Cu3O7 and PrBa2Cu4O8 systems based on LSDA+U approach

International Nuclear Information System (INIS)

Shirazi, M.; Tavana, A.; Akhavan, M.

2007-01-01

Full text: The electronic structures of PrBa 2 Cu 3 O 7 (Pr123) and PrBa 2 Cu 4 O 8 (Pr124) have been obtained by means of the density functional theory in the local spin density approximation plus on-site Coulomb interaction. The correlation correction has been applied to the Cu 3d and Pr 4f states. Calculations show that the localized Pr-O bands form near the Fermi surface and do not cross the Fermi level. Comparison of the hole absorbing ability of pfy and the pdy states shows that pfy state has dominant role in grabbing holes from the system and causes Pr124 to be non-superconducting like Pr123. We suggest that hybridization of Pr and O atoms in Pr124 system is weaker than Pr123 compound and this may be the reason for the higher critical doping of Pr by which the superconductivity is completely suppressed. Displacement of the conduction bands at the Fermi level is the criterion of Cu (3dx2-y2) character, and when Cu (3dx2-y2) character is stronger in a band, the band displaces more intensively under applying the correction Ucu. We estimate the hole-concentration from this displacement, and good agreement with experiment is seen. The displacement of the CuO 2 plane bands in the minority and majority spin channels in Pr124 is less than that in Pr123. Displacement of the double chain bands in Pr124 is higher than the single chain bands in Pr123. This feature is related to a stronger Cu (3dx2-y2) character in the double chain. So, the spin and conduction features of the Pr124 double chains are stronger than Pr123 single chain, which is the origin of metallic behavior of Pr124 at low temperatures.(authors)

Electronic structures of PrBa2Cu3O7 and PrBa2Cu4O8 systems based on LSDA+U approach

International Nuclear Information System (INIS)

Shirazi, M.; Tavana, A.; Akhavan, M.

2007-01-01

Full text: The electronic structures of PrBa 2 Cu 3 O 7 (Pr123) and PrBa 2 Cu 4 O 8 (Pr124) have been obtained by means of the density functional theory in the local spin density approximation plus on-site Coulomb interaction. The correlation correction has been applied to the Cu 3d and Pr 4f states. Calculations show that the localized Pr-O bands form near the Fermi surface and do not cross the Fermi level. Comparison of the hole absorbing ability of pfy and the pdy states shows that pfy state has dominant role in grabbing holes from the system and causes Pr124 to be non-superconducting like Pr123. We suggest that hybridization of Pr and O atoms in Pr124 system is weaker than Pr123 compound and this may be the reason for the higher critical doping of Pr by which the superconductivity is completely suppressed. Displacement of the conduction bands at the Fermi level is the criterion of Cu (3dx2-y2) character, and when Cu (3dx2-y2) character is stronger in a band, the band displaces more intensively under applying the correction Ucu. We estimate the hole-concentration from this displacement, and good agreement with experiment is seen. The displacement of the CuO 2 plane bands in the minority and majority spin channels in Pr124 is less than that in Pr123. Displacement of the double chain bands in Pr124 is higher than the single chain bands in Pr123. This feature is related to a stronger Cu (3dx2-y2) character in the double chain. So, the spin and conduction features of the Pr124 double chains are stronger than Pr123 single chain, which is the origin of metallic behavior of Pr124 at low temperatures. (authors)

Purification and Fibrillation of Full-Length Recombinant PrP.

Science.gov (United States)

Makarava, Natallia; Savtchenko, Regina; Baskakov, Ilia V

2017-01-01

Misfolding and aggregation of prion protein are related to several neurodegenerative diseases in humans such as Creutzfeldt-Jakob disease, fatal familial insomnia, and Gerstmann-Straussler-Scheinker disease. A growing number of applications in the prion field including assays for detection of PrP Sc and methods for production of PrP Sc de novo require recombinant prion protein (PrP) of high purity and quality. Here, we report an experimental procedure for expression and purification of full-length mammalian prion protein. This protocol has been proved to yield PrP of extremely high purity that lacks PrP adducts, oxidative modifications, or truncation, which is typically generated as a result of spontaneous oxidation or degradation. We also describe methods for preparation of amyloid fibrils from recombinant PrP in vitro. Recombinant PrP fibrils can be used as a noninfectious synthetic surrogate of PrP Sc for development of prion diagnostics including generation of PrP Sc -specific antibody.

SUZAKU OBSERVATIONS OF THE X-RAY BRIGHTEST FOSSIL GROUP ESO 3060170

International Nuclear Information System (INIS)

Su, Yuanyuan; White, Raymond E. III; Miller, Eric D.

2013-01-01

'Fossil' galaxy groups, each dominated by a relatively isolated giant elliptical galaxy, have many properties intermediate between groups and clusters of galaxies. We used the Suzaku X-ray observatory to observe the X-ray brightest fossil group, ESO 3060170, out to R 200 , in order to better elucidate the relation between fossil groups, normal groups, and clusters. We determined the intragroup gas temperature, density, and metal abundance distributions and derived the entropy, pressure, and mass profiles for this group. The entropy and pressure profiles in the outer regions are flatter than in simulated clusters, similar to what is seen in observations of massive clusters. This may indicate that the gas is clumpy and/or the gas has been redistributed. Assuming hydrostatic equilibrium, the total mass is estimated to be ∼1.7 × 10 14 M ☉ within a radius R 200 of ∼1.15 Mpc, with an enclosed baryon mass fraction of 0.13. The integrated iron mass-to-light ratio of this fossil group is larger than in most groups and comparable to those of clusters, indicating that this fossil group has retained the bulk of its metals. A galaxy luminosity density map on a scale of 25 Mpc shows that this fossil group resides in a relatively isolated environment, unlike the filamentary structures in which typical groups and clusters are embedded

PrPC displays an essential protective role from oxidative stress in an astrocyte cell line derived from PrPC knockout mice

International Nuclear Information System (INIS)

Bertuchi, Fernanda R.; Bourgeon, Dominique M.G.; Landemberger, Michele C.; Martins, Vilma R.; Cerchiaro, Giselle

2012-01-01

Highlights: ► PrP C in solution acts as a radical scavenger. ► PrP C reduces hydrogen peroxide toxicity in astrocytes. ► Increase in ROS disrupted the cell cycle in the PrP C -knockout astrocytes. ► PrP C prevents the cell death independently of an SOD-like activity. -- Abstract: The PrP C protein, which is especially present in the cellular membrane of nervous system cells, has been extensively studied for its controversial antioxidant activity. In this study, we elucidated the free radical scavenger activity of purified murine PrP C in solution and its participation as a cell protector in astrocytes that were subjected to treatment with an oxidant. In vitro and using an EPR spin-trapping technique, we observed that PrP C decreased the oxidation of the DMPO trap in a Fenton reaction system (Cu 2+ /ascorbate/H 2 O 2 ), which was demonstrated by approximately 70% less DMPO/OH · . In cultured PrP C -knockout astrocytes from mice, the absence of PrP C caused an increase in intracellular ROS (reactive oxygen species) generation during the first 3 h of H 2 O 2 treatment. This rapid increase in ROS disrupted the cell cycle in the PrP C -knockout astrocytes, which increased the population of cells in the sub-G1 phase when compared with cultured wild-type astrocytes. We conclude that PrP C in solution acts as a radical scavenger, and in astrocytes, it is essential for protection from oxidative stress caused by an external chemical agent, which is a likely condition in human neurodegenerative CNS disorders and pathological conditions such as ischemia.

Einstein Ring in Distant Universe

Science.gov (United States)

2005-06-01

Using ESO's Very Large Telescope, Rémi Cabanac and his European colleagues have discovered an amazing cosmic mirage, known to scientists as an Einstein Ring. This cosmic mirage, dubbed FOR J0332-3557, is seen towards the southern constellation Fornax (the Furnace), and is remarkable on at least two counts. First, it is a bright, almost complete Einstein ring. Second, it is the farthest ever found. ESO PR Photo 20a/05 ESO PR Photo 20a/05 Deep Image of a Region in Fornax (FORS/VLT) [Preview - JPEG: 400 x 434 pix - 60k] [Normal - JPEG: 800 x 867 pix - 276k] [Full Res - JPEG: 1859 x 2015 pix - 3.8M] ESO PR Photo 20b/05 ESO PR Photo 20b/05 Zoom-in on the Newly Found Einstein Ring (FORS/VLT) [Preview - JPEG: 400 x 575 pix - 168k] [Normal - JPEG: 630 x 906 pix - 880k] Caption: ESO PR Photo 20a/05 is a composite image taken in two bands (B and R) with VLT/FORS1 of a small portion of the sky (field-of-view 7x7' or 1/15th of the area of the full moon). The faintest object seen in the image has a magnitude 26, that is, it is 100 million times fainter than what can be observed with the unaided eye. The bright elliptical galaxy on the lower-left quadrant is a dwarf galaxy part of a large nearby cluster in the Fornax constellation. As for all deep images of the sky, this field shows a variety of objects, the brightest ponctual sources being stars from our Galaxy. By far the field is dominated by thousands of faint background galaxies the colours of which are related to the age of their dominant stellar population, their dust content and their distance. The newly found Einstein ring is visible in the top right part of the image. ESO PR Photo 20b/05 zooms-in on the position of the newly found cosmic mirage. ESO PR Photo 20c/05 ESO PR Photo 20c/05 Einstein Ring in Distant Universe (FORS/VLT) [Preview - JPEG: 400 x 584 pix - 104k] [Normal - JPEG: 800 x 1168 pix - 292k] [Full Res - JPEG: 1502 x 2192 pix - 684k] Caption of ESO PR Photo 20c/05: The left image is magnified and centred

SOFIA/GREAT Discovery of Terahertz Water Masers

Science.gov (United States)

Neufeld, David A.; Melnick, Gary J.; Kaufman, Michael J.; Wiesemeyer, Helmut; Güsten, Rolf; Kraus, Alex; Menten, Karl M.; Ricken, Oliver; Faure, Alexandre

2017-07-01

We report the discovery of water maser emission at frequencies above 1 THz. Using the GREAT instrument on SOFIA, we have detected emission in the 1.296411 THz {8}27-{7}34 transition of water toward three oxygen-rich evolved stars: W Hya, U Her, and VY CMa. An upper limit on the 1.296 THz line flux was obtained toward R Aql. Near-simultaneous observations of the 22.23508 GHz {6}16-{5}23 water maser transition were carried out toward all four sources using the Effelsberg 100 m telescope. The measured line fluxes imply 22 GHz/1.296 THz photon luminosity ratios of 0.012, 0.12, and 0.83, respectively, for W Hya, U Her, and VY CMa, values that confirm the 22 GHz maser transition to be unsaturated in W Hya and U Her. We also detected the 1.884888 THz {8}45-{7}52 transition toward W Hya and VY CMa, and the 1.278266 THz {7}43-{6}52 transition toward VY CMa. Like the 22 GHz maser transition, all three of the THz emission lines detected here originate from the ortho-H2O spin isomer. Based upon a model for the circumstellar envelope of W Hya, we estimate that stimulated emission is responsible for ˜85% of the observed 1.296 THz line emission, and thus that this transition may be properly described as a terahertz-frequency maser. In the case of the 1.885 THz transition, by contrast, our W Hya model indicates that the observed emission is dominated by spontaneous radiative decay, even though a population inversion exists. GREAT is a development by the MPI für Radioastronomie and the KOSMA/Universität zu Köln, in cooperation with the MPI für Sonnensystemforschung and the DLR Institut für Planetenforschung.

A Glimpse of the Very Early Universal Web

Science.gov (United States)

2001-05-01

The VLT Maps Extremely Distant Galaxies Summary New, trailblazing observations with the ESO Very Large Telescope (VLT) at Paranal lend strong support to current computer models of the early universe: It is "spongy", with galaxies forming along filaments, like droplets along the strands of a spiders web. A group of astronomers at ESO and in Denmark [1] determined the distances to some very faint galaxies in the neighbourhood of a distant quasar. Plotting their positions in a three-dimensional map, they found that these objects are located within a narrow "filament", exactly as predicted by the present theories for the development of the first structures in the young universe . The objects are most likely "building blocks" from which galaxies and clusters of galaxies assemble. This observation shows a very useful way forward for the study of the early evolution of the universe and the emergence of structures soon after the Big Bang. At the same time, it provides yet another proof of the great power of the new class of giant optical telescopes for cosmological studies. PR Photo 19a/01 : Web-like structures in the young Universe (computer model). PR Photo 19b/01 : A group of objects at redshift 3.04 . PR Photo 19c/01 : Animated view of sky field and distant filament . PR Photo 19d/01 : The shape of the filament . PR Photo 19e/01 : Artist's impression of the very distant filament. PR Video Clip 04/01 : Video animation of the very distant filament. The computers are ahead of the telescopes For the past two decades cosmologists have been in the somewhat odd situation that their computers were "ahead" of their telescopes. The rapid evolution of powerful computer hardware and sophisticated software has provided theorists with the ability to build almost any sort of virtual universe they can imagine. Starting with different initial conditions just after the Big Bang, they can watch such fictional worlds evolve over billions of years in their supercomputers - and do so in a

Electrocardiographic PR-interval duration and cardiovascular risk

DEFF Research Database (Denmark)

Rasmussen, Peter Vibe; Nielsen, Jonas Bille; Skov, Morten Wagner

2017-01-01

Background Because of ambiguous reports in the literature, we aimed to investigate the association between PR interval and the risk of all-cause and cardiovascular death, heart failure, and pacemaker implantation, allowing for a nonlinear relationship. MethodsWe included 293,111 individuals...... into 7 groups based on the population PR interval distribution. Cox models were used, with reference to a PR interval between 152 and 161 ms (40th to heart failure...... adjustment. A long PR interval conferred an increased risk of heart failure ( > 200 ms; HR, 1.31; 95% CI, 1.22-1.42; P 200 ms (HR, 3...

Effects of substitute coated with hyaluronic acid or poly-lactic acid on implant fixation. Experimental study in ovariectomized and glucocorticoid treated sheep

DEFF Research Database (Denmark)

Andreasen, Christina M; Ding, Ming; Andersen, Thomas L

2018-01-01

Investigated in healthy animal models, hyaluronic acid (HyA) and poly-D,L -lactic acid (PDLLA) demonstrate osteoconductive properties when coated onto hydroxyapatite (HA) and β-tricalcium phosphate (βTCP) scaffolds. In this study, we examined the efficacy of HA/βTCP granules coated with HyA or PD...... formation, HyA and PDDLA are indeed considered valuable as new coating materials for composite ceramics when tested in a sheep model - even in bones of a compromised quality.......Investigated in healthy animal models, hyaluronic acid (HyA) and poly-D,L -lactic acid (PDLLA) demonstrate osteoconductive properties when coated onto hydroxyapatite (HA) and β-tricalcium phosphate (βTCP) scaffolds. In this study, we examined the efficacy of HA/βTCP granules coated with Hy...... allograft obtained from a healthy donor sheep (control), pure HA/βTCP, HA/βTCP-HyA or HA/βTCP-PDLLA. After 12 weeks, the bone formation adjacent to the implant surface was evaluated by histology and histomorphometry, while the implant fixation was measured by a push-out test. The investigation showed a bone...

Coming Home at Paranal

Science.gov (United States)

2002-02-01

Unique "Residencia" Opens at the VLT Observatory Summary The Paranal Residencia at the ESO VLT Observatory is now ready and the staff and visitors have moved into their new home. This major architectural project has the form of a unique subterranean construction with a facade opening towards the Pacific Ocean , far below at a distance of about 12 km. Natural daylight is brought into the building through a 35-m wide glass-covered dome, a rectangular courtyard roof and various skylight hatches. Located in the middle of the Atacama Desert, one of the driest areas on Earth, the Residencia incorporates a small garden and a swimming pool, allowing the inhabitants to retreat from time to time from the harsh outside environment. Returning from long shifts at the VLT and other installations on the mountain, here they can breathe moist air and receive invigorating sensory impressions. With great originality of the design, it has been possible to create an interior with a feeling of open space - this is a true "home in the desert" . Moreover, with strict ecological power, air and water management , the Paranal Residencia has already become a symbol of innovative architecture in its own right. Constructed with robust, but inexpensive materials, it is an impressively elegant and utilitarian counterpart to the VLT high-tech facilities poised some two hundred meters above, on the top of the mountain. PR Photo 05a/02 : Aerial view of the Paranal Observatory area. PR Photo 05b/02 : Aerial view of the Paranal Residencia . PR Photo 05c/02 : Outside view of the Paranal Residencia . PR Photo 05d/02 : The Entry Hall (fisheye view). PR Photo 05e/02 : The Entry Hall with garden and pool. PR Photo 05f/02 : The Reception Area . PR Photo 05g/02 : The Reception Area - decoration. PR Photo 05h/02 : The Reception Area - decoration. PR Photo 05i/02 : The Reception Area - decoration. PR Photo 05j/02 : View towards the Cantine . PR Photo 05k/02 : View towards the Kitchen . PR Photo 05l/02 : View

Redox induces diverse effects on recombinant human wild-type PrP and mutated PrP with inserted or deleted octarepeats.

Science.gov (United States)

Shi, Qi; Chen, Cao; Zhang, Bao-Yun; Zhou, Wei; Xiao, Kang; Dong, Xiao-Ping

2018-04-01

Normal prion protein (PrP) contains two cysteines at amino acids 179 and 214, which may form intra‑ and interpeptide disulfide bonds. To determine the possible effects of this disulfide bridge on the biochemical features of PrP, prokaryotic recombinant human wild‑type PrP (PG5), and mutated PrPs with seven extra octarepeats (PG12) or with all five octarepeats removed (PG0), were subjected to redox in vitro. Sedimentation assays revealed a large portion of aggregation in redox‑treated PG5, but not in PG0 and PG12. Circular dichroism analysis detected increased β‑sheet and decreased α‑helix in PG5 subjected to redox, increased random‑coil and decreased β‑sheet in PG0, and increased random‑coil, but limited changes to β‑sheet content, in PG12. Thioflavin T fluorescence tests indicated that fluorescent value was increased in PG5 subjected to redox. In addition, proteinase K (PK) digestions indicated that PK resistance was stronger in PG12 and PG0 compared with in PG5; redox enhanced the PK resistance of all three PrP constructs, particularly PG0 and PG12. These data indicated that formation of a disulfide bond induces marked alterations in the secondary structure and biochemical characteristics of PrP. In addition, the octarepeat region within the PrP peptide markedly influences the effects of redox on the biochemical phenotypes of PrP, thus highlighting the importance of the number of octarepeats in the biological functions of PrP.

PrPc Does Not Mediate Internalization of PrPSc but Is Required at an Early Stage for De Novo Prion Infection of Rov Cells▿

Science.gov (United States)

Paquet, Sophie; Daude, Nathalie; Courageot, Marie-Pierre; Chapuis, Jérôme; Laude, Hubert; Vilette, Didier

2007-01-01

We have studied the interactions of exogenous prions with an epithelial cell line inducibly expressing PrPc protein and permissive to infection by a sheep scrapie agent. We demonstrate that abnormal PrP (PrPSc) and prion infectivity are efficiently internalized in Rov cells, whether or not PrPc is expressed. At odds with earlier studies implicating cellular heparan sulfates in PrPSc internalization, we failed to find any involvement of such molecules in Rov cells, indicating that prions can enter target cells by several routes. We further show that PrPSc taken up in the absence of PrPc was unable to promote efficient prion multiplication once PrPc expression was restored in the cells. This observation argues that interaction of PrPSc with PrPc has to occur early, in a specific subcellular compartment(s), and is consistent with the view that the first prion multiplication events may occur at the cell surface. PMID:17626095

Detection of spectroscopic binaries in the Gaia-ESO Survey

Science.gov (United States)

Van der Swaelmen, M.; Merle, T.; Van Eck, S.; Jorissen, A.

2017-12-01

The Gaia-ESO survey (GES) is a ground-based spectroscopic survey, complementing the Gaia mission, in order to obtain high accuracy radial velocities and chemical abundances for 10^5 stars. Thanks to the numerous spectra collected by the GES, the detection of spectroscopic multiple system candidates (SBn, n ≥ 2) is one of the science case that can be tackled. We developed at IAA (Institut d'Astronomie et d'Astrophysique) a novative automatic method to detect multiple components from the cross-correlation function (CCF) of spectra and applied it to the CCFs provided by the GES. Since the bulk of the Milky Way field targets has been observed in both HR10 and HR21 GIRAFFE settings, we are also able to compare the efficiency of our SB detection tool depending on the wavelength range. In particular, we show that HR21 leads to a less efficient detection compared to HR10. The presence of strong and/or saturated lines (Ca II triplet, Mg I line, Paschen lines) in the wavelength domain covered by HR21 hampers the computation of CCFs, which tend to be broadened compared to their HR10 counterpart. The main drawback is that the minimal detectable radial velocity difference is ˜ \\SI{60}km/s for HR21 while it is ˜ \\SI{25}km/s for HR10. A careful design of CCF masks (especially masking Ca triplet lines) can substantially improve the detectability rate of HR21. Since HR21 spectra are quite similar to the one produced by the RVS spectrograph of the Gaia mission, analysis of RVS spectra in the context of spectroscpic binaries can take adavantage of the lessons learned from the GES to maximize the detection rate.

More Saturnian Moons

Science.gov (United States)

2000-10-01

Saturn takes the lead Following the discovery of at least four additional moons of that planet, Saturn has again taken the lead as the planet with the greatest number of known natural satellites. A corresponding announcement was made today by an international team of astronomers [1] at a meeting of the Division for Planetary Sciences (DPS) of the American Astronomical Society (AAS) in Pasadena (California, USA). The four new faint bodies were spotted during observations in August-September 2000 at several astronomical telescopes around the world. Subsequent orbital calculations have indicated that these objects are almost certainly new satellites of the giant planet. Two Saturnian moons found at La Silla ESO PR Photo 29a/00 ESO PR Photo 29a/00 [Preview - JPEG: 263 x 400 pix - 26k] [Normal - JPEG: 525 x 800 pix - 93k] ESO PR Photo 29b/00 ESO PR Photo 29b/00 [Preview - JPG: 289 x 400 pix - 43k] [Normal - JPG: 578 x 800 pix - 432k] ESO PR Photo 29c/00 ESO PR Photo 29c/00 [Animated GIF: 330 x 400 pix - 208k] Captions : The photos show the discovery images of two new Saturnian moons, as registered on August 7, 2000, with the Wide-Field Imager (WFI) camera at the MPG/ESO 2.2-m telescope at the La Silla Observatory. Photo PR 29a/00 displays the faint image of the newly discovered moon S/2000 S 1 in the lower right corner of the field. A spiral galaxy is seen in the upper left corner of this photo. The other objects are (background) stars in the Milky Way. Photo PR 29b/00 is a combination of three successive WFI exposures of the second moon, S/2000 S 2 . Because of its motion, there are three images (to the left). Photo PR 29c/00 is an animated GIF image of the same three exposures that demonstrates this motion. Technical details are found below. The observations of the first two objects are described on a Circular of the International Astronomical Union (IAU) that was issued today [2]. The images of these new moons were first registered on exposures made on August 7, 2000

Bases para la elaboracion de unidades didacticas de calidad en el area de ciencias (Fisica y Quimica 3 deg ESO)

Science.gov (United States)

Maccioni, Elena Lucia

Este Trabajo Fin de Master tiene como objeto, el estudio previo de la educacion de la ciencia en la actualidad y mas destacable, del diseno de las unidades didacticas segun las metodologias mas frecuentes aplicadas por los diferentes sistemas educativos en el area de las Ciencias teniendo en cuenta la importancia y el efecto de la psicologia del alumnado y todo ello como no puede ser de otro modo bajo el corse de la Legislacion aplicable, Estatal, Autonomica y europea. Con estos antecedentes, se extrae cuales son las preguntas que deben contestarse en la elaboracion de una unidad didactica de calidad en el contexto, generacional (edad y sexo), del Proyecto Educativo de Centro, y de la Programacion del Departamento, discutiendo y justificando cada uno de los apartados en que estructuradamente dividiremos dicha Unidad, con un formato manejable, util, y dinamico en el tiempo que sea un verdadero instrumento educativo de aula. Teniendo en cuenta estas premisas, se procede a hacer una recopilacion de una misma unidad didactica publicada por diferentes editoriales, elegidas no al azar, sino en funcion de su penetracion editorial en nuestros centros de ESO, siendo las elegidas (SM y Oxford). Las diferentes unidades seleccionadas son analizadas de forma critica, atendiendo a los criterios generales de calidad bajo parametros cientificos y normativos, concluyendo con la aportacion final que es la redaccion de unas pautas cientifico-pedagogicas, para redactar unidades didacticas de calidad en el area de la Ciencias, en concreto en la Asignatura de Fisica y Quimica de 3º de ESO.

Crystal structure of PrOHSO4

International Nuclear Information System (INIS)

Fahey, J.A.; Williams, G.J.B.; Haschke, J.M.

1979-01-01

PrOHSO 4 was prepared by hydrothermal reaction of Pr(OH) 3 with Pr 2 (SO 4 ) 3 x H 2 O at 450 to 500 0 C and 1,200 +- 200 atm water pressure. The space group is P2 1 /c; the cell parameters are a = 4.488, b = 12.495, c = 7.091 A, β = 111.08, Z = 4, d/sub x/ = 4.49 g/cm 3 . Atomic coordinates and anisotropic thermal parameters are tabulated. A stereoscopic protection of the cation coordination sphere is shown and discussed. 2 figures, 3 tables

Experimental Models of Inherited PrP Prion Diseases.

Science.gov (United States)

Watts, Joel C; Prusiner, Stanley B

2017-11-01

The inherited prion protein (PrP) prion disorders, which include familial Creutzfeldt-Jakob disease, Gerstmann-Sträussler-Scheinker disease, and fatal familial insomnia, constitute ∼10%-15% of all PrP prion disease cases in humans. Attempts to generate animal models of these disorders using transgenic mice expressing mutant PrP have produced variable results. Although many lines of mice develop spontaneous signs of neurological illness with accompanying prion disease-specific neuropathological changes, others do not. Furthermore, demonstrating the presence of protease-resistant PrP species and prion infectivity-two of the hallmarks of the PrP prion disorders-in the brains of spontaneously sick mice has proven particularly challenging. Here, we review the progress that has been made toward developing accurate mouse models of the inherited PrP prion disorders. Copyright © 2017 Cold Spring Harbor Laboratory Press; all rights reserved.

Biro Konsultan PR dan Kompetensi Praktisi PR di Era Industrialisasi Komunikasi dan Pencitraan

Directory of Open Access Journals (Sweden)

Dina Sekar Vusparatih

2013-04-01

Full Text Available The world of communication starts to experience rapid development in various aspects of life, almost all over the world. In Indonesia, it is marked by the emergence of a lot of tv and radio stations, and started the trend of imaging strategy efforts that is used to win the regional election, nasional election, and even to win marketing competition through company’s products or services image branding. This phenomenon is the opportunity for PR consultants to be successful team in designing appropriate communication strategies and appropriate steps to build the image. This opportunity is used by many people which is characterized by the proliferation of consultancies. Competition between consultants becomes so tight considering the companies or organizations that intend to hire consultants also want the best. Competitive bidding process was conducted, to win this, it needs solid team of consultants required in skills and morally. PR competencies of each member are needed to grow into a successful PR consultant. 

Teoria e prática das práticas alternativas

Directory of Open Access Journals (Sweden)

Fernando D. de Avila-Pires

1995-04-01

Full Text Available São abordados, os fundamentos científicos e a ética da utilização das práticas de medicina alternativa em voga no Brasil. Ressalta-se que, em geral, o termo alternativo não é definido e que pode se referir aos princípios básicos ou aos métodos de diagnóstico e tratamento. Sugere-se que a escolha individual de um sistema terapêutico é mais influenciada por fatores culturais, pela tradição familiar e pela moda, do que pela análise racional dos seus fundamentos. Estabelece-se que o que distingue realmente os diferentes sistemas são seus princípios e não suas práticas.

Teoria e prática das práticas alternativas

Directory of Open Access Journals (Sweden)

Avila-Pires Fernando D. de

1995-01-01

Full Text Available São abordados, os fundamentos científicos e a ética da utilização das práticas de medicina alternativa em voga no Brasil. Ressalta-se que, em geral, o termo alternativo não é definido e que pode se referir aos princípios básicos ou aos métodos de diagnóstico e tratamento. Sugere-se que a escolha individual de um sistema terapêutico é mais influenciada por fatores culturais, pela tradição familiar e pela moda, do que pela análise racional dos seus fundamentos. Estabelece-se que o que distingue realmente os diferentes sistemas são seus princípios e não suas práticas.

Na+/K+-ATPase is present in scrapie-associated fibrils, modulates PrP misfolding in vitro and links PrP function and dysfunction.

Directory of Open Access Journals (Sweden)

James F Graham

Full Text Available Transmissible spongiform encephalopathies are characterised by widespread deposition of fibrillar and/or plaque-like forms of the prion protein. These aggregated forms are produced by misfolding of the normal prion protein, PrP(C, to the disease-associated form, PrP(Sc, through mechanisms that remain elusive but which require either direct or indirect interaction between PrP(C and PrP(Sc isoforms. A wealth of evidence implicates other non-PrP molecules as active participants in the misfolding process, to catalyse and direct the conformational conversion of PrP(C or to provide a scaffold ensuring correct alignment of PrP(C and PrP(Sc during conversion. Such molecules may be specific to different scrapie strains to facilitate differential prion protein misfolding. Since molecular cofactors may become integrated into the growing protein fibril during prion conversion, we have investigated the proteins contained in prion disease-specific deposits by shotgun proteomics of scrapie-associated fibrils (SAF from mice infected with 3 different strains of mouse-passaged scrapie. Concomitant use of negative control preparations allowed us to identify and discount proteins that are enriched non-specifically by the SAF isolation protocol. We found several proteins that co-purified specifically with SAF from infected brains but none of these were reproducibly and demonstrably specific for particular scrapie strains. The α-chain of Na(+/K(+-ATPase was common to SAF from all 3 strains and we tested the ability of this protein to modulate in vitro misfolding of recombinant PrP. Na(+/K(+-ATPase enhanced the efficiency of disease-specific conversion of recombinant PrP suggesting that it may act as a molecular cofactor. Consistent with previous results, the same protein inhibited fibrillisation kinetics of recombinant PrP. Since functional interactions between PrP(C and Na(+/K(+-ATPase have previously been reported in astrocytes, our data highlight this molecule as

Political PR is dying. Long live business PR! / Ilyn Oleg

Index Scriptorium Estoniae

Oleg, Ilyn

2005-01-01

Vene suurima suhtekorraldusagentuuri Imageland Public Relations rahvusvaheliste suhete juhi hinnangul on Venemaal peamisteks probleemideks PR professionaalide vähesus, nende kehv haritus oma erialal, samuti vähene teadlikkus suhtekorralduse tähtsusest äris

Profesi PR Identik dengan Perempuan ?

Directory of Open Access Journals (Sweden)

Neni Yulianita

2004-09-01

Full Text Available Profesi Public Relations (PR atau di Indonesia lebih dikenal dengan Humas, seringkali diidentikkan dengan profesi yang pantas dijabat oleh kaum perempuan. Adanya sebagian kalangan masyarakat yang menjudge bahwa profesi ini lebih tepat dijabat oleh kaum perempuan, dengan alasan profesi ini menuntut keterampilan, daya tarik, dan keluwesan. Dengan adanya anggapan tersebut,  tentu saja telah memberikan implikasi pada kaum laki-laki  sehingga menimbulkan keraguan pada mereka untuk menekuni bidang kajian PR/Humas di berbagai Perguruan Tinggi yang memiliki bidang ini. Ironisnya, user masih menganggap kaum laki-lakilah yang lebih tepat menjabat profesi PR, dengan anggapan antara lain bahwa laki-laki lebih energik, aktif, rasional, agresif, memiliki stamina atau fisik yang lebih kuat, dan memiliki kemampuan dalam penguasaan hardware atau teknologi komunikasi mutakhir yang lebih baik dibanding wanita yang dianggap lebih emosional, pasif, dan submisif. Anggapan ini tentu saja sangat merugikan perempuan,  walaupun hasil penelitian Robins dinyatakan bahwa,  “Tidak ada beda  laki-laki dan perempuan yang konsisten dalam kemampuan memecahkan masalah, keterampilan analitis, dorongan kompetitif, motivasi, sosiobilitas, atau kemampuan belajar”.  Untuk itu, dalam tulisan ini, penulis menyajikan jawaban apakah benar Profesi PR lebih tepat dijabat oleh Perempuan?

Prion propagation in cells expressing PrP glycosylation mutants.

Science.gov (United States)

Salamat, Muhammad K; Dron, Michel; Chapuis, Jérôme; Langevin, Christelle; Laude, Hubert

2011-04-01

Infection by prions involves conversion of a host-encoded cell surface protein (PrP(C)) to a disease-related isoform (PrP(Sc)). PrP(C) carries two glycosylation sites variably occupied by complex N-glycans, which have been suggested by previous studies to influence the susceptibility to these diseases and to determine characteristics of prion strains. We used the Rov cell system, which is susceptible to sheep prions, to generate a series of PrP(C) glycosylation mutants with mutations at one or both attachment sites. We examined their subcellular trafficking and ability to convert into PrP(Sc) and to sustain stable prion propagation in the absence of wild-type PrP. The susceptibility to infection of mutants monoglycosylated at either site differed dramatically depending on the amino acid substitution. Aglycosylated double mutants showed overaccumulation in the Golgi compartment and failed to be infected. Introduction of an ectopic glycosylation site near the N terminus fully restored cell surface expression of PrP but not convertibility into PrP(Sc), while PrP(C) with three glycosylation sites conferred cell permissiveness to infection similarly to the wild type. In contrast, predominantly aglycosylated molecules with nonmutated N-glycosylation sequons, produced in cells expressing glycosylphosphatidylinositol-anchorless PrP(C), were able to form infectious PrP(Sc). Together our findings suggest that glycosylation is important for efficient trafficking of anchored PrP to the cell surface and sustained prion propagation. However, properly trafficked glycosylation mutants were not necessarily prone to conversion, thus making it difficult in such studies to discern whether the amino acid changes or glycan chain removal most influences the permissiveness to prion infection.

Thermoelectric power of PrMg3

Science.gov (United States)

Isikawa, Yosikazu; Somiya, Kazuya; Koyanagi, Huruto; Mizushima, Toshio; Kuwai, Tomohiko; Tayama, Takashi

2010-01-01

PrMg3 is supposed to be one of the strongly correlated electron systems originated from the hybridization between the Pr 4f and conduction electrons, because the gigantic electronic specific heat coefficient C/T was observed at low temperatures. However, a typical behaviour of - ln T dependence was not observed in the temperature dependence of the electrical resistivity. The thermoelectric power S is a powerful tool to investigate the density of states at the Fermi energy. We measured carefully the thermoelectric power of PrMg3 in the temperature range between 2 and 300 K. S is extremely small, ranged within ±1 μV/K over the whole temperature. The value of S/T at low temperature limit was also significantly smaller than expected from the specific heat results. We therefore conclude that the density of state at the Fermi level is not enhanced in PrMg3.

Thermoelectric power of PrMg3

International Nuclear Information System (INIS)

Isikawa, Yosikazu; Somiya, Kazuya; Koyanagi, Huruto; Mizushima, Toshio; Kuwai, Tomohiko; Tayama, Takashi

2010-01-01

PrMg 3 is supposed to be one of the strongly correlated electron systems originated from the hybridization between the Pr 4f and conduction electrons, because the gigantic electronic specific heat coefficient C/T was observed at low temperatures. However, a typical behaviour of - ln T dependence was not observed in the temperature dependence of the electrical resistivity. The thermoelectric power S is a powerful tool to investigate the density of states at the Fermi energy. We measured carefully the thermoelectric power of PrMg 3 in the temperature range between 2 and 300 K. S is extremely small, ranged within ±1 μV/K over the whole temperature. The value of S/T at low temperature limit was also significantly smaller than expected from the specific heat results. We therefore conclude that the density of state at the Fermi level is not enhanced in PrMg 3 .

Prépositions et rection verbale étude des prépositions avec, contre, en, par, parmi, pour

CERN Document Server

Ashino, Fumitake; Paillard, Denis

2017-01-01

Cet ouvrage étudie une série de prépositions du français (avec, contre, par, parmi, en et pour) dont la caractéristique commune est d'introduire un terme (Y) constituant un mode d'appréhension particulier du terme (X) avec lequel ces prépositions établissent une relation (X prép Y), et dont un grand nombre d'emplois sont liés à la rection verbale.

THE 0.5-2.22 μm SCATTERED LIGHT SPECTRUM OF THE DISK AROUND TW Hya: DETECTION OF A PARTIALLY FILLED DISK GAP AT 80 AU

International Nuclear Information System (INIS)

Debes, John H.; Jang-Condell, Hannah; Weinberger, Alycia J.; Roberge, Aki; Schneider, Glenn

2013-01-01

We present a 0.5-2.2 μm scattered light spectrum of the circumstellar disk around TW Hya from a combination of spatially resolved Hubble Space Telescope STIS spectroscopy and NICMOS coronagraphic images of the disk. We investigate the morphology of the disk at distances >40 AU over this wide range of wavelengths, and identify the presence of a depression in surface brightness at ∼80 AU that could be caused by a gap in the disk. Additionally, we quantify the surface brightness, azimuthal symmetry, and spectral character of the disk as a function of radius. Our analysis shows that the scattering efficiency of the dust is largely neutral to blue over the observed wavelengths. We model the disk as a steady α-disk with an ad hoc gap structure. The thermal properties of the disk are self-consistently calculated using a three-dimensional radiative transfer code that uses ray tracing to model the heating of the disk interior and scattered light images. We find a good fit to the data over a wide range of distances from the star if we use a model disk with a partially filled gap of 30% depth at 80 AU and with a self-similar truncation knee at 100 AU. The origin of the gap is unclear, but it could arise from a transition in the nature of the disk's dust composition or the presence of a planetary companion. Based on scalings to previous hydrodynamic simulations of gap-opening criteria for embedded proto-planets, we estimate that a planetary companion forming the gap could have a mass between 6 and 28 M ⊕ .

Demographic differences in PrEP–related stereotypes: Implications for implementation

Science.gov (United States)

Golub, Sarit. A.; Gamarel, Kristi E.; Surace, Anthony

2015-01-01

Qualitative interviews about pre-exposure prophylaxis (PrEP) stereotypes were conducted with a subsample of 160 MSM who participated in a PrEP messaging study. Negative stereotypes about PrEP users were identified by 80% of participants. Two types of stereotypes were most common: PrEP users are HIV-infected (and lying about it), and PrEP users are promiscuous and resistant to condom use. Participants’ identification of these stereotype categories differed significantly by demographic factors (i.e. race/ethnicity, education). Expanding access to PrEP requires recognizing potential differences in the experience or anticipation of PrEP-related stereotypes that might impact willingness to discuss PrEP with providers, friends, or partners. PMID:26143247

Interaction between 14-3-3β and PrP influences the dimerization of 14-3-3 and fibrillization of PrP106-126.

Science.gov (United States)

Han, Jun; Song, Qin-Qin; Sun, Peng; Zhang, Jin; Wang, Xu; Song, Juan; Li, Gong-Qi; Liu, Ying-Hui; Mei, Guo-Yong; Shi, Qi; Tian, Chan; Chen, Cao; Gao, Chen; Zhao, Bo; Dong, Xiao-Ping

2014-02-01

Proteins of the 14-3-3 family are universal participate in multiple cellular processes. However, their exact role in the pathogenesis of prion diseases remains unclear. In this study, we proposed that human PrP was able to form molecular complex with 14-3-3β. The domains responsible for the interactions between PrP and 14-3-3β were mapped at the segments of amino acid (aa) residues 106-126 within PrP and aa 1-38 within 14-3-3β. Homology modeling revealed that the key aa residues for molecular interaction were D22 and D23 in 14-3-3β as well as K110 in PrP. Mutations in these aa residues inhibited the interaction between the two proteins in vitro. Our results also showed that recombinant PrP encouraged 14-3-3β dimer formation, whereas PrP106-126 peptide inhibited it. Recombinant 14-3-3β disaggregated the mature PrP106-126 fibrils in vitro. Moreover, the PrP-14-3-3 protein complexes were observed in the brain tissues of normal and scrapie agent 263K infected hamsters. Colocalization of PrP and 14-3-3 was seen in the cytoplasm of human neuroblastoma cell line SH-SY5Y, as well as human cervical cancer cell line HeLa transiently expressing full-length human PrP. Our current data suggest the neuroprotection of PrPC and neuron damage caused by PrPSc may be associated with their functions of 14-3-3 dimerization regulation. Copyright © 2013 Elsevier Ltd. All rights reserved.

Radio- and VUV - Excited Luminescence of YAP:Ce, YAP:Pr and YAG:Pr

Science.gov (United States)

2001-01-01

Pr 3+ ions.", Acta Physica Polonica A, 90 pp.407-10, 1996. 6. C. Pedrini, D. Bouttet, C. Dujardin, B. Moine, I. Dafinei, P. Lecoq, M. Koselja, K...34Spectroscopy and thermoluminescence of LuAIO 3:Ce" Acta Physica Polonica A,.90, pp.377-383, 1996 17. A.J. Wojtowicz, J. Glodo, W. Drozdowski, K.R. Przegietka...Malinowski, M.F. Joubert, B. Jacquier. "Simultaneous laser action at blue and orange wavelengths in YAG:Pr 3+ Physica Status Solidi A, 140, pp.K49-52, 1993 5

Mechanically alloyed PrFeB nanocrystalline magnets

International Nuclear Information System (INIS)

Kaszuwara, W.; Leonowicz, M.

1998-01-01

Mechanically alloyed PrFeB nanocrystalline magnets were prepared by extensive ball milling of Pr, Fe and Fe 80 B 20 powders, followed by diffusion annealing. After milling, the material consisted of nanocrystalline α-Fe crystallites embedded in amorphous Pr-rich matrix. Thermomagnetic and calorimetric investigations of the transformations which occurred during annealing showed that the amorphous phase crystallised at 240 C, leading to the formation of crystalline Pr having lattice constants 10% greater than those shown in the ASTM data. This fact indicated that mechanical alloying and low temperature annealing led to the formation of a solid solution of either Fe or B in Pr, which does not exist in the equilibrium state. The Pr 2 Fe 14 B phase was subsequently formed within a temperature range of 420-620 C. The magnetic properties of magnets depend on the phase structure and grain size. Milling time appears to be a decisive processing parameter for the tailoring of the magnetic properties. Depending on the phase structure, the coercivities varied from 100 to 1200 kA/m and, respectively, the remanences from 0.98 T to 0.6 T. The highest maximum energy product was 80 kJ/m 3 . (orig.)

Effects of FlAsH/Tetracysteine (TC) tag on PrP proteolysis and PrPres formation by TC-scanning

Science.gov (United States)

Taguchi, Yuzuru; Hohsfield, Lindsay A.; Hollister, Jason R.

2014-01-01

The FlAsH/tetracysteine (FlAsH/TC) tag is a powerful tool for fluorescent labeling of proteins. However, even small tags such as FlAsH/TC could alter the behavior of the tagged proteins, especially if the insertion occurs at internal sites. Defining the influence of FlAsH/TC on nearby protein-protein interactions might aid in selecting appropriate positions for internal TC insertions and allow the exploitation of serial FlAsH/TC insertions (TC-scanning) as a probe to characterize sites of protein-protein interaction. To explore this application in the context of substrate-protease interactions, we analyzed the effect of FlAsH/TC insertions on proteolysis of cellular prion protein (PrPsen) in in vitro reactions and generation of the C1 metabolic fragment of PrPsen in live neuroblastoma cells. The influence of FlAsH/TC insertion was evaluated by TC-scanning across the cleavage sites of each protease. The results showed that FlAsH/TC inhibited protease cleavage only within limited ranges of the cleavage sites that varied from about 1 to 6 residues-wide depending on the protease, providing an estimate of the PrP residues interacting with each protease. TC-scanning was also used to probe a different type of protein-protein interaction, the conformational conversion of FlAsH-PrPsen to the prion disease-associated isoform, PrPres. PrP constructs with FlAsH/TC insertions at residues 90–96 but not 97–101 were converted to FlAsH-PrPres, identifying a boundary separating loosely versus compactly folded regions of PrPres. Our observations demonstrate that TC-scanning with the FlAsH/TC tag can be a versatile method for probing protein-protein interactions and folding processes. PMID:23943295

Investigating SLIM Disk Solutions FOR HLX-1 IN ESO 243-49

Science.gov (United States)

Godet, O.; Plazolles, B.; Kawaguchi, T.; Lasota, J.-P; Barret, d.; Farrell, S. A.; Braito, V.; Servillat, M.; Webb, N.; Gehrels, N.

2012-01-01

The hyperluminous X-ray source HLX-1 in the galaxy ESO 243-49, currently the best intermediate-mass blackhole (BH) candidate, displays spectral transitions similar to those observed in Galactic BH binaries, but with aluminosity 100-1000 times higher. We investigated the X-ray properties of this unique source by fitting multiepochdata collected by Swift, XMM-Newton, and Chandra with a disk model computing spectra for a wide rangeof sub- and super-Eddington accretion rates assuming a non-spinning BH and a face-on disk (i=0 deg.). Under theseassumptions we find that the BH in HLX-1 is in the intermediate-mass range (approximately 2 x 10(exp 4) solar mass) and the accretionflow is in the sub-Eddington regime. The disk radiation efficiency is eta = 0.11 plus or minus 0.03. We also show that the source does follow the LX is proportional to T(exp 4) relation for our mass estimate. At the outburst peaks, the source radiates near the Eddington limit. The accretion rate then stays constant around 4 x 10(exp 4) solar mass yr (sup -1) for several days and then decreases exponentially. Such plateaus in the accretion rate could be evidence that enhanced mass-transfer rateis the driving outburst mechanism in HLX-1. We also report on the new outburst observed in 2011 August by theSwift X-Ray Telescope. The time of this new outburst further strengthens the approximately 1 year recurrence timescale.

Study of PrP - I heterogeneous equilibrium

International Nuclear Information System (INIS)

Vasil'eva, I.G.; Mironov, K.E.; Tarasenko, A.D.

1976-01-01

Using static methods the authors have measured the equilibrium vapor pressure in the system PrP+I 2 at different temperatures and different initial iodine concentrations. The equilibrium reactions in the system have been determined. The reaction of PrP with iodine is irreversible. The content of PrI 3 and I 2 in the gas phase is negligible. The pressure in the system is determined by the partial pressure of phosphorus

Préface

Science.gov (United States)

Chardonnet, Christian; Millot, Guy

2006-10-01

COLOQ, réunion nationale biennale initiée en 1988 par la communauté française des lasers, de l'optique non linéaire et de l'optique quantique atteint sa neuvième édition. Depuis sa création, les objectifs poursuivis sont les suivants : - réunir la communauté française des lasers, de l'optique non linéaire et de l'optique quantique, en dépassant les clivages fondamental/appliqué, recherche publique/industrielle, - faire le point sur les avancées récentes, - permettre aux jeunes chercheurs de se rencontrer, de s'exprimer et de s'aguerrir au plan national. Le but est que tout thésard du domaine de l'optique puisse participer à COLOQ une fois durant sa thèse, présenter son travail et de se confronter à la communauté de l'optique. COLOQ9 s'est tenu, pour sa 9e édition, sur le campus universitaire de Dijon, du 7 au 9 septembre 2005. Il a été une grande réussite : nombre de participants (255) et de présentations scientifiques record (148 affiches), forte représentation des industriels (15) et participation d'environ 200 lycéens aux conférences grand public. Le nombre plus élevé que prévu d'affiches a rendu un peu serrée leur présentation : une attention particulière sera portée à cet aspect lors des prochaines éditions. Ces journées ont été consacrées à des conférences invitées données par des scientifiques de haut niveau et à des présentations sous forme d'affiches. Une plage de temps importante a été réservée pour des discussions autour des affiches. À proximité immédiate de la salle de conférence, l'exposition de matériels spécialisés pour les lasers, l'optique et l'optoélectronique a été une occasion pour les jeunes participants de découvrir et contacter les industriels et les autres grands acteurs de l'optique. L'année 2005 ayant été l'année mondiale de la physique, COLOQ9 a retenu comme thème central ”1905-2005 : à propos d'Einstein". Plusieurs grandes conférences ont été dédiées à ce th

Singlet ground-state fluctuations in praseodymium observed by muon spin relaxation in PrP and PrP0.9

International Nuclear Information System (INIS)

Noakes, D R; Waeppling, R; Kalvius, G M; Jr, M F White; Stronach, C E

2005-01-01

Muon spin relaxation (μSR) in the singlet ground-state compounds PrP and PrP 0.9 reveals the unusual situation of a Lorentzian local field distribution with fast-fluctuation-limit strong-collision dynamics, a case that does not show motional narrowing. Contrary to publications by others, where PrP 0.9 was asserted to have vacancy-induced spin-glass freezing, no spin-glass freezing is seen in PrP 0.9 or PrP down to ≤100mK. This was confirmed by magnetization measurements on these same samples. In both compounds, the muon spin relaxation rate does increase as temperature decreases, demonstrating increasing strength of the paramagnetic response. A Monte Carlo model of fluctuations of Pr ions out of their crystalline-electric-field singlet ground states into their magnetic excited states (and back down again) produces the strong-collision-dynamic Lorentzian relaxation functions observed at each individual temperature but not the observed temperature dependence. This model contains no exchange interaction, and so predicts decreasing paramagnetic response as the temperature decreases, contrary to the temperature dependence observed. Comparison of the simulations to the data suggests that the exchange interaction is causing the system to approach magnetic freezing (by mode softening), but fails to complete the process

Cathodoluminescence properties of SiO2:Pr3+and ZnO.SiO2:Pr3+ phosphor nanopowders

CSIR Research Space (South Africa)

Mhlongo, GH

2010-10-01

Full Text Available regardless of the incorporation of Pr3+ and nanocrystalline ZnO or annealing at 600 °C. The particles were mostly spherical and agglomerated as confirmed by Field Emission Scanning Electron Microscopy. Thermogravimetric analysis of dried gels performed... Science, vol. 45(19): 5228-5236 Cathodoluminescence properties of SiO2:Pr 3+and ZnO·SiO2:Pr 3+ phosphor nanopowders G. H. Mhlongo, O. M. Ntwaeaborwa, M. S. Dhlamini, H. C. Swart, K. T. Hillie ABSTRACT: The successful incorporation of Zn...

Modelos de atención de los padecimientos: de exclusiones teóricas y articulaciones prácticas

Directory of Open Access Journals (Sweden)

Menéndez Eduardo L.

2003-01-01

Full Text Available En las sociedades latinoamericanas existen diversos modelos de atención de los padecimientos que son considerados en forma aislada y hasta antagónica por el sector salud, en lugar de observar las estrechas relaciones que se dan entre esos modelos a través de las prácticas y representaciones de los sujetos que los utilizan. En este trabajo se describen las relaciones que existen entre la biomedicina y la autoatención, para evidenciar el continuo proceso de transacciones que operan entre las mismas. Primero se describen algunas características básicas de la biomedicina y de la autoatención, para luego observar las transacciones que existen entre ambas, especialmente a través de la prescripción de fármacos y de la automedicación. Este proceso transaccional tiende a ser ignorado por la biomedicina, que critica los procesos de automedicación, lo que resulta paradojal dado que la biomedicina y sobre todo el sector salud impulsan procesos de autoatención que incluyen la automedicación, sin reflexionar sobre la articulación y sobre las consecuencias que estas transacciones tienen para el proceso salud/enfermedad/atención. Se propone la necesidad no sólo de reflexionar sobre estos procesos transaccionales, sino de utilizarlos intencionalemnte desde el sector salud.

Ghosts of Milky Way's past: the globular cluster ESO 37-1 (E 3)

Science.gov (United States)

de la Fuente Marcos, R.; de la Fuente Marcos, C.; Moni Bidin, C.; Ortolani, S.; Carraro, G.

2015-09-01

Context. In the Milky Way, most globular clusters are highly conspicuous objects that were found centuries ago. However, a few dozen of them are faint, sparsely populated systems that were identified largely during the second half of the past century. One of the faintest is ESO 37-1 (E 3) and as such it remains poorly studied, with no spectroscopic observations published so far although it was discovered in 1976. Aims: We investigate the globular cluster E 3 in an attempt to better constrain its fundamental parameters. Spectroscopy of stars in the field of E 3 is shown here for the first time. Methods: Deep, precise VI CCD photometry of E 3 down to V ~ 26 mag is presented and analysed. Low-resolution, medium signal-to-noise ratio spectra of nine candidate members are studied to derive radial velocity and metallicity. Proper motions from the UCAC4 catalogue are used to explore the kinematics of the bright members of E 3. Results: Isochrone fitting indicates that E 3 is probably very old, with an age of about 13 Gyr; its distance from the Sun is nearly 10 kpc. It is also somewhat metal rich with [Fe/H] = -0.7. Regarding its kinematics, our tentative estimate for the proper motions is (μα cosδ,μδ) = (-7.0 ± 0.8, 3.5 ± 0.3) mas yr-1 (or a tangential velocity of 382 ± 79 km s-1) and for the radial velocity 45 ± 5 km s-1 in the solar rest frame. Conclusions: E 3 is one of the most intriguing globular clusters in the Galaxy. Having an old age and being metal rich is clearly a peculiar combination, only seen in a handful of objects like the far more conspicuous NGC 104 (47 Tucanae). In addition, its low luminosity and sparse population make it a unique template for the study of the final evolutionary phases in the life of a star cluster. Unfortunately, E 3 is among the most elusive and challenging known globular clusters because field contamination severely hampers spectroscopic studies. This research note is based on observations made with the ESO VLT at the

Novel receptor-like kinases in cacao contain PR-1 extracellular domains.

Science.gov (United States)

Teixeira, Paulo José Pereira Lima; Costa, Gustavo Gilson Lacerda; Fiorin, Gabriel Lorencini; Pereira, Gonçalo Amarante Guimarães; Mondego, Jorge Maurício Costa

2013-08-01

Members of the pathogenesis-related protein 1 (PR-1) family are well-known markers of plant defence responses, forming part of the arsenal of the secreted proteins produced on pathogen recognition. Here, we report the identification of two cacao (Theobroma cacao L.) PR-1s that are fused to transmembrane regions and serine/threonine kinase domains, in a manner characteristic of receptor-like kinases (RLKs). These proteins (TcPR-1f and TcPR-1g) were named PR-1 receptor kinases (PR-1RKs). Phylogenetic analysis of RLKs and PR-1 proteins from cacao indicated that PR-1RKs originated from a fusion between sequences encoding PR-1 and the kinase domain of a LecRLK (Lectin Receptor-Like Kinase). Retrotransposition marks surround TcPR-1f, suggesting that retrotransposition was involved in the origin of PR-1RKs. Genes with a similar domain architecture to cacao PR-1RKs were found in rice (Oryza sativa), barrel medic (Medicago truncatula) and a nonphototrophic bacterium (Herpetosiphon aurantiacus). However, their kinase domains differed from those found in LecRLKs, indicating the occurrence of convergent evolution. TcPR-1g expression was up-regulated in the biotrophic stage of witches' broom disease, suggesting a role for PR-1RKs during cacao defence responses. We hypothesize that PR-1RKs transduce a defence signal by interacting with a PR-1 ligand. © 2013 BSPP AND JOHN WILEY & SONS LTD.

Dancing around the Black Hole

Science.gov (United States)

2001-08-01

, however, and will soon disrupt. At some moment, many of those young stars may get too close to the monster in the centre and suffer an unhappy fate... PR Photo 25a/01 : The active galaxy NGC 1097 (R-band image) PR Photo 25b/01 : The active galaxy NGC 1808 (H-band image) PR Photo 25c/01 : The active galaxy NGC 5728 (K-band image) PR Photo 25d/01 : Schematic drawing of the various structural components mentioned in the text. PR Photo 25e/01 : ISAAC spectrum (2.3 µm) of the central region of NGC 1808 PR Photo 25f/01 : Stellar motions at the centre of NGC 1808 Central black holes in galaxies ESO PR Photo 25a/01 ESO PR Photo 25a/01 [Preview - JPEG: 400 x 489 pix - 39k] [Normal - JPEG: 800 x 977 pix - 296k] ESO PR Photo 25b/01 ESO PR Photo 25b/01 [Preview - JPEG: 400 x 499 pix - 40k] [Normal - JPEG: 800 x 997 pix - 168k] ESO PR Photo 25c/01 ESO PR Photo 25c/01 [Preview - JPEG: 400 x 488 pix - 47k] [Normal - JPEG: 800 x 975 pix - 384k] Caption : Photos of three active galaxies that were observed with ISAAC during the present programme. They show NGC 1097 (R-band; Photo 25a/01) and the central areas of NGC 1808 (H-band; Photo 25b/01) and NGC 5728 (K-band; Photo 25c/01). The bar-like structures and the luminous centres where the Black Holes are located are well visible - they are discussed in the text. The distances to these galaxies are approximately 55, 35 and 120 million light-years, respectively; the local scales are indicated in the photos. Technical information about these photos is available below. Recent research with space- and ground-based astronomical telescopes indicate that there are very heavy Black Holes at the centres of most galaxies. There is also general agreement among scientists that many of the closest neighbours of our own Milky Way Galaxy, for example the large spiral Andromeda Galaxy and the peculiar Centaurus A galaxy (cf. ESO PR 04/01 ), do contain central black holes with masses from millions to billions of solar masses [2]. Black Holes have an

77 FR 68102 - Foreign-Trade Zone 163-Ponce, PR; Application for Subzone; Zimmer Manufacturing BV; Ponce, PR

Science.gov (United States)

2012-11-15

... DEPARTMENT OF COMMERCE Foreign-Trade Zones Board [B-81-2012] Foreign-Trade Zone 163--Ponce, PR; Application for Subzone; Zimmer Manufacturing BV; Ponce, PR An application has been submitted to the Foreign-Trade Zones Board (the Board) by CODEZOL, C.D., grantee of FTZ 163, requesting special- purpose subzone...

An outflow in the Seyfert ESO 362-G18 revealed by Gemini-GMOS/IFU observations

Science.gov (United States)

Humire, Pedro K.; Nagar, Neil M.; Finlez, Carolina; Firpo, Verónica; Slater, Roy; Lena, Davide; Soto-Pinto, Pamela; Muñoz-Vergara, Dania; Riffel, Rogemar A.; Schmitt, Henrique R.; Kraemer, Steven B.; Schnorr-Müller, Allan; Fischer, Travis C.; Robinson, Andrew; Storchi-Bergmann, Thaisa; Crenshaw, Mike; Elvis, Martin S.

2018-06-01

We present two-dimensional stellar and gaseous kinematics of the inner 0.7 × 1.2 kpc2 of the Seyfert 1.5 galaxy ESO 362-G18, derived from optical (4092-7338 Å) spectra obtained with the GMOS integral field spectrograph on the Gemini South telescope at a spatial resolution of ≈170 pc and spectral resolution of 36 km s-1. ESO 362-G18 is a strongly perturbed galaxy of morphological type Sa or S0/a, with a minor merger approaching along the NE direction. Previous studies have shown that the [O III] emission shows a fan-shaped extension of ≈10'' to the SE. We detect the [O III] doublet, [N II] and Hα emission lines throughout our field of view. The stellar kinematics is dominated by circular motions in the galaxy plane, with a kinematic position angle of ≈137° and is centred approximately on the continuum peak. The gas kinematics is also dominated by rotation, with kinematic position angles ranging from 122° to 139°, projected velocity amplitudes of the order of 100 km s-1, and a mean velocity dispersion of 100 km s-1. A double-Gaussian fit to the [O III]λ5007 and Hα lines, which have the highest signal to noise ratios of the emission lines, reveal two kinematic components: (1) a component at lower radial velocities which we interpret as gas rotating in the galactic disk; and (2) a component with line of sight velocities 100-250 km s-1 higher than the systemic velocity, interpreted as originating in the outflowing gas within the AGN ionization cone. We estimate a mass outflow rate of 7.4 × 10-2 M⊙ yr-1 in the SE ionization cone (this rate doubles if we assume a biconical configuration), and a mass accretion rate on the supermassive black hole (SMBH) of 2.2 × 10-2 M⊙ yr-1. The total ionized gas mass within 84 pc of the nucleus is 3.3 × 105 M⊙; infall velocities of 34 km s-1 in this gas would be required to feed both the outflow and SMBH accretion. The reduced datacube (FITS file) is only available at the CDS via anonymous ftp to http

Family planning providers' role in offering PrEP to women.

Science.gov (United States)

Seidman, Dominika; Weber, Shannon; Carlson, Kimberly; Witt, Jacki

2018-03-09

Pre-exposure prophylaxis (PrEP) provides a radically different HIV prevention option for women. Not only is PrEP the first discrete, woman-controlled method that is taken in advance of exposure, but it is both safe and highly effective, offering over 90% protection if taken daily. While multiple modalities of PrEP are in development ranging from vaginal rings to injectables and implants, only PrEP with oral tenofovir/emtricitabine is currently FDA-approved. Family planning clinics provide key access points for many women to learn about and obtain PrEP. By incorporating PrEP services into family planning care, family planning providers have the opportunity to meet women's expectations, ensure women are aware of and offered comprehensive HIV prevention options, and reverse emerging disparities in PrEP access. Despite real and perceived barriers to integrating PrEP into family planning care, providing PrEP services, ranging from education to onsite provision, is not only possible but an important component of providing high-quality sexual and reproductive healthcare to women. Lessons learned from early adopters will help guide those in family planning settings initiating or enhancing PrEP services. Copyright © 2018. Published by Elsevier Inc.

Assistência pré-natal no Brasil

Directory of Open Access Journals (Sweden)

Elaine Fernandes Viellas

2014-08-01

Full Text Available O estudo tem por objetivo analisar a assistência pré-natal oferecida às gestantes usuárias de serviços de saúde públicos e/ou privados utilizando dados da pesquisa Nascer no Brasil, realizada em 2011 e 2012. As informações foram obtidas por meio de entrevista com a puérpera durante a internação hospitalar e dados do cartão de pré- natal. Os resultados mostram cobertura elevada da assistência pré-natal (98,7% tendo 75,8% das mulheres iniciado o pré-natal antes da 16a semana gestacional e 73,1% compareceram a seis ou mais consultas. O pré-natal foi realizado, sobretudo, em unidades básicas (89,6%, públicas (74,6%, pelo mesmo profissional (88,4%, em sua maioria médicos (75,6%, e 96% receberam o cartão de pré-natal. Um quarto das gestantes foi considerado de risco. Do total das entrevistadas, apenas 58,7% foram orientadas sobre a maternidade de referência, e 16,2% procuraram mais de um serviço para a admissão para o parto. Desafios persistem para a melhoria da qualidade dessa assistência, com a realização de procedimentos efetivos para a redução de desfechos desfavoráveis.

Study on GIF PR/PP evaluation methodology

Energy Technology Data Exchange (ETDEWEB)

Lee, B. H.; Kwon, E. H.; Kim, H. D. [KAERI, Daejeon (Korea, Republic of)

2012-10-15

Proliferation resistance (PR) and physical protection (PP) is one of the four technology goals of generation IV nuclear energy systems (NESs). The PR component of the goal focuses on providing strong assurance that generation IV NESs are the least desirable sources for the diversion or undeclared production of nuclear materials, whereas the PP portion of the goal ensures that generation IV NESs are robust against theft and sabotage. In 2002, the road map of the Generation IV International Forum (GIF) envisioned that the R and D program for PR and PP would have three areas: 1) safeguards and physical protection technology R and D for each GIF system; 2) formulation of PR and PP criteria and metrics; and 3) evaluation of the criteria and metrics. To cover these R and D items, the PR and PP Working Group (PRPPWG) was formed in late 2002 and has since developed a methodology for PR and PP evaluation. In a succession of revisions beginning in 2004, consensus was achieved amongst all participating GIF countries and related organizations (i.e., IAEA and EU), and Revision 6 of the methodology report was approved by GIF for open distribution in 2011. The paper describes in detail the methodology developed by the PRPPWG and discusses its applicability to the sodium-cooled fast reactor (SFR) fuel cycle with pyro processing currently under development in Korea.

Familial CJD Associated PrP Mutants within Transmembrane Region Induced Ctm-PrP Retention in ER and Triggered Apoptosis by ER Stress in SH-SY5Y Cells

Science.gov (United States)

Wang, Xin; Shi, Qi; Xu, Kun; Gao, Chen; Chen, Cao; Li, Xiao-Li; Wang, Gui-Rong; Tian, Chan; Han, Jun; Dong, Xiao-Ping

2011-01-01

Background Genetic prion diseases are linked to point and inserted mutations in the prion protein (PrP) gene that are presumed to favor conversion of the cellular isoform of PrP (PrPC) to the pathogenic one (PrPSc). The pathogenic mechanisms and the subcellular sites of the conversion are not completely understood. Here we introduce several PRNP gene mutations (such as, PrP-KDEL, PrP-3AV, PrP-A117V, PrP-G114V, PrP-P102L and PrP-E200K) into the cultured cells in order to explore the pathogenic mechanism of familial prion disease. Methodology/Principal Findings To address the roles of aberrant retention of PrP in endoplasmic reticulum (ER), the recombinant plasmids expressing full-length human PrP tailed with an ER signal peptide at the COOH-terminal (PrP-KDEL) and PrP with three amino acids exchange in transmembrane region (PrP-3AV) were constructed. In the preparations of transient transfections, 18-kD COOH-terminal proteolytic resistant fragments (Ctm-PrP) were detected in the cells expressing PrP-KDEL and PrP-3AV. Analyses of the cell viabilities in the presences of tunicamycin and brefeldin A revealed that expressions of PrP-KDEL and PrP-3AV sensitized the transfected cells to ER stress stimuli. Western blots and RT-PCR identified the clear alternations of ER stress associated events in the cells expressing PrP-KDEL and PrP-3AV that induced ER mediated apoptosis by CHOP and capase-12 apoptosis pathway. Moreover, several familial CJD related PrP mutants were transiently introduced into the cultured cells. Only the mutants within the transmembrane region (G114V and A117V) induced the formation of Ctm-PrP and caused the ER stress, while the mutants outside the transmembrane region (P102L and E200K) failed. Conclusions/Significance The data indicate that the retention of PrP in ER through formation of Ctm-PrP results in ER stress and cell apoptosis. The cytopathic activities caused by different familial CJD associated PrP mutants may vary, among them the mutants

Familial CJD associated PrP mutants within transmembrane region induced Ctm-PrP retention in ER and triggered apoptosis by ER stress in SH-SY5Y cells.

Directory of Open Access Journals (Sweden)

Xin Wang

Full Text Available BACKGROUND: Genetic prion diseases are linked to point and inserted mutations in the prion protein (PrP gene that are presumed to favor conversion of the cellular isoform of PrP (PrP(C to the pathogenic one (PrP(Sc. The pathogenic mechanisms and the subcellular sites of the conversion are not completely understood. Here we introduce several PRNP gene mutations (such as, PrP-KDEL, PrP-3AV, PrP-A117V, PrP-G114V, PrP-P102L and PrP-E200K into the cultured cells in order to explore the pathogenic mechanism of familial prion disease. METHODOLOGY/PRINCIPAL FINDINGS: To address the roles of aberrant retention of PrP in endoplasmic reticulum (ER, the recombinant plasmids expressing full-length human PrP tailed with an ER signal peptide at the COOH-terminal (PrP-KDEL and PrP with three amino acids exchange in transmembrane region (PrP-3AV were constructed. In the preparations of transient transfections, 18-kD COOH-terminal proteolytic resistant fragments (Ctm-PrP were detected in the cells expressing PrP-KDEL and PrP-3AV. Analyses of the cell viabilities in the presences of tunicamycin and brefeldin A revealed that expressions of PrP-KDEL and PrP-3AV sensitized the transfected cells to ER stress stimuli. Western blots and RT-PCR identified the clear alternations of ER stress associated events in the cells expressing PrP-KDEL and PrP-3AV that induced ER mediated apoptosis by CHOP and caspase-12 apoptosis pathway. Moreover, several familial CJD related PrP mutants were transiently introduced into the cultured cells. Only the mutants within the transmembrane region (G114V and A117V induced the formation of Ctm-PrP and caused the ER stress, while the mutants outside the transmembrane region (P102L and E200K failed. CONCLUSIONS/SIGNIFICANCE: The data indicate that the retention of PrP in ER through formation of Ctm-PrP results in ER stress and cell apoptosis. The cytopathic activities caused by different familial CJD associated PrP mutants may vary, among them

ALUMNADO INMIGRANTE EN LA ESO: VULNERABILIDAD PEDAGÓGICA DEL SISTEMA EDUCATIVO

Directory of Open Access Journals (Sweden)

Juan Fernández Sierra

2017-01-01

Full Text Available Es preocupante el alto porcentaje de alumnado inmigrante que no culmina con éxito la enseñanza obligatoria, extendiéndose una tendencia de pensamiento docente que identifica las causas con cuestiones de índole personal, sociofamiliar o cultural. Sin embargo, parece razonable indagar en qué yerra nuestro sistema educativo que no logra superar esa situación. En esa línea, el objetivo esencial de esta investigación ha sido indagar en los puntos débiles o vulnerabilidad del sistema (Reimer, 1973 para responder a este escenario, enfocándolo desde la perspectiva de los planteamientos de política curricular y examinando las raíces institucionales y pedagógicas que inciden en la deserción y fracaso escolar. Para ello, hemos realizado un diseño de corte naturalista basado en ocho estudios instrumentales de caso, llevados a cabo en otros tantos institutos de diversas características, desarrollándolos al modo de lo que Stake (2007 denomina estudio colectivo de casos. En cuanto a los resultados y conclusiones, damos especial relevancia al tándem formado por la que podríamos denominar vulnerabilidad intrínseca —actitudes y prácticas hegemónicas mediatizadas por la cultura profesional instalada en este nivel educativo— y la vulnerabilidad estructural —políticas educativas y curriculares—, que se retroalimentan mutuamente, construyendo una resistencia simbólica, normativa y de práctica pedagógica, inhibidora de los intentos innovadores para reorientar la acción educativa hacia dimensiones más inclusivas, multiculturales e interculturales. Los estereotipos y la cultura académica previa experimentada por las familias y prole, también se muestran como factores significativos de vulnerabilidad. El diseño empleado, por su propia naturaleza, no permite generalizar los hallazgos, pero sí posee un alto poder de transferibilidad y de aportación de interpretaciones y asertos para seguir comprendiendo las complejidades de la

Electronic structures of PrBa{sub 2}Cu{sub 3}O{sub 7}, Pr{sub 2}Ba{sub 4}Cu{sub 7}O{sub 15-y}(y=0,1), and PrBa{sub 2}Cu{sub 4}O{sub 8} based on LSDA+U method

Energy Technology Data Exchange (ETDEWEB)

Tavana, A. [Magnet Research Laboratory (MRL), Department of Physics, Sharif University of Technology, Tehran (Iran); Department of Physics, University of Mohaghegh Ardabili, Ardabil (Iran); Shirazi, M.; Akhavan, M. [Magnet Research Laboratory (MRL), Department of Physics, Sharif University of Technology, Tehran (Iran)

2009-10-15

The electronic structures of PrBa{sub 2}Cu{sub 3}O{sub 7} (Pr123), Pr{sub 2}Ba{sub 4}Cu{sub 7}O{sub 15-y} (Pr247), and PrBa{sub 2}Cu{sub 4}O{sub 8} (Pr124) cuprates have been obtained using density-functional theory in the local spin density approximation plus onsite Coulomb interaction (LSDA+U). Onsite Hubbard correlation, U, has been considered for Pr-f and Cu-d orbitals and the effects of considering these correlation corrections on the Pr-O hybridizations have been inspected. Results imply that the Pr ionization state in Pr123 system is constituted from two different configurations, and the energy of the f states in these two configurations has an important role in superconductivity properties of the system. Our calculations also show that in both Pr124 and Pr247 systems, suppression of superconductivity is weaker than that in the Pr123 system. This occurs due to the weaker Pr-O bond in both Pr124 and Pr247 systems. The role of the double chain and single chain on the conduction properties of these compounds has been investigated. We have also studied the effect of oxygen deficiency in Pr247 system, which seems to revive superconductivity in this system. Investigating the hole carriers in the CuO{sub 2} plane shows a correlation between superconductivity suppression and hole decrement in the planes. (Abstract Copyright [2009], Wiley Periodicals, Inc.)

PrP mRNA and protein expression in brain and PrP(c) in CSF in Creutzfeldt-Jakob disease MM1 and VV2.

Science.gov (United States)

Llorens, Franc; Ansoleaga, Belén; Garcia-Esparcia, Paula; Zafar, Saima; Grau-Rivera, Oriol; López-González, Irene; Blanco, Rosi; Carmona, Margarita; Yagüe, Jordi; Nos, Carlos; Del Río, José Antonio; Gelpí, Ellen; Zerr, Inga; Ferrer, Isidre

2013-01-01

Creutzfeldt-Jakob disease (CJD) is a heterogenic neurodegenerative disorder associated with abnormal post-translational processing of cellular prion protein (PrP(c)). CJD displays distinctive clinical and pathological features which correlate with the genotype at the codon 129 (methionine or valine: M or V respectively) in the prion protein gene and with size of the protease-resistant core of the abnormal prion protein PrP(sc) (type 1: 20/21 kDa and type 2: 19 kDa). MM1 and VV2 are the most common sporadic CJD (sCJD) subtypes. PrP mRNA expression levels in the frontal cortex and cerebellum are reduced in sCJD in a form subtype-dependent. Total PrP protein levels and PrP(sc) levels in the frontal cortex and cerebellum accumulate differentially in sCJD MM1 and sCJD VV2 with no relation between PrP(sc) deposition and spongiform degeneration and neuron loss, but with microgliosis, and IL6 and TNF-α response. In the CSF, reduced PrP(c), the only form present in this compartment, occurs in sCJD MM1 and VV2. PrP mRNA expression is also reduced in the frontal cortex in advanced stages of Alzheimer disease, Lewy body disease, progressive supranuclear palsy, and frontotemporal lobe degeneration, but PrP(c) levels in brain varies from one disease to another. Reduced PrP(c) levels in CSF correlate with PrP mRNA expression in brain, which in turn reflects severity of degeneration in sCJD.

ER and PR expression and survival after endometrial cancer.

Science.gov (United States)

Smith, Deborah; Stewart, Colin J R; Clarke, Edward M; Lose, Felicity; Davies, Claire; Armes, Jane; Obermair, Andreas; Brennan, Donal; Webb, Penelope M; Nagle, Christina M; Spurdle, Amanda B

2018-02-01

To measure association between endometrial carcinoma ER and PR status and endometrial cancer (EC) survival, accounting for inter-observer variation. The intensity and proportion of tumor cell expression of ER and PR in ECs were assessed independently and semi-quantitatively by two pathologists using digital images of duplicate tumor tissue microarrays (TMAs). Cases with inconsistent initial assessment were reviewed and final scoring agreed. The association between overall and EC-specific survival and hormone receptor expression (intensity, proportion and combined) was assessed using Cox regression analysis. The C-index was used to evaluate model discrimination with addition of ER and PR status. Tumor ER and PR analysis was possible in 659 TMAs from 255 patients, and in 459 TMAs from 243 patients, respectively. Initial ER and PR scoring was consistent in 82% and 80% of cases, respectively. In multivariate analyses decreased ER and PR expression was associated with increased tumor-related mortality. Associations reached statistical significance for ER proportion score (P=0.05), ER intensity score (P=0.003), and PR combined score (P=0.04). Decreased expression of combined ER/PR expression was associated with poorer EC-specific survival than decreased expression of either hormone receptor alone (P=0.005). However, hormone receptor status did not significantly improve mortality prediction in individual cases. ER and PR expression combined, using cut-points that capture variation in scoring and across cores, is significantly associated with EC-specific survival in analyses adjusting for known prognostic factors. However, at the individual level, ER and PR expression does not improve mortality prediction. Copyright © 2017 Elsevier Inc. All rights reserved.

Acetylcholinesterase triggers the aggregation of PrP 106-126

International Nuclear Information System (INIS)

Pera, M.; Roman, S.; Ratia, M.; Camps, P.; Munoz-Torrero, D.; Colombo, L.; Manzoni, C.; Salmona, M.; Badia, A.; Clos, M.V.

2006-01-01

Acetylcholinesterase (AChE), a senile plaque component, promotes amyloid-β-protein (Aβ) fibril formation in vitro. The presence of prion protein (PrP) in Alzheimer's disease (AD) senile plaques prompted us to assess if AChE could trigger the PrP peptides aggregation as well. Consequently, the efficacy of AChE on the PrP peptide spanning-residues 106-126 aggregation containing a coumarin fluorescence probe (coumarin-PrP 106-126) was studied. Kinetics of coumarin-PrP 106-126 aggregation showed a significant increase of maximum size of aggregates (MSA), which was dependent on AChE concentration. AChE-PrP 106-126 aggregates showed the tinctorial and optical amyloid properties as determined by polarized light and electronic microscopy analysis. A remarkable inhibition of MSA was obtained with propidium iodide, suggesting that AChE triggers PrP 106-126 and Aβ aggregation through a similar mechanism. Huprines (AChE inhibitors) also significantly decreased MSA induced by AChE as well, unveiling the potential interest for some AChE inhibitors as a novel class of potential anti-prion drugs

Purification and Fibrillation of Full-Length Recombinant PrP

OpenAIRE

Makarava, Natallia; Baskakov, Ilia V.

2012-01-01

Misfolding and aggregation of prion protein (PrP) is related to several neurodegenerative diseases in humans such as Creutzfeldt–Jacob disease, fatal familial insomnia, and Gerstmann–Straussler–Sheinker disease. Certain applications in prion area require recombinant PrP of high purity and quality. Here, we report an experimental procedure for expression and purification of full-length mammalian PrP. This protocol has been proved to yield PrP of extremely high purity that lac...

Los riesgos para los niños que usan internet

OpenAIRE

Instituto Argentino de Computación IAC

2015-01-01

Los niños que navegan por Internet pueden ser víctimas de hechos criminales, explotación y pornografía. No hay restricciones para publicar cualquier material por eso es responsabilidad de padres y maestros, así como personal la responsabilidad de asegurarse que los sitios de Internet sean seguros y apropiados. Relata los riesgos que existen, da consejos prácticos a los padres y reglas familiares porque no resulta práctico prohibirles a los niños el uso del Internet.

The Drifting Star

Science.gov (United States)

2008-04-01

By studying in great detail the 'ringing' of a planet-harbouring star, a team of astronomers using ESO's 3.6-m telescope have shown that it must have drifted away from the metal-rich Hyades cluster. This discovery has implications for theories of star and planet formation, and for the dynamics of our Milky Way. ESO PR Photo 09a/08 ESO PR Photo 09a/08 Iota Horologii The yellow-orange star Iota Horologii, located 56 light-years away towards the southern Horologium ("The Clock") constellation, belongs to the so-called "Hyades stream", a large number of stars that move in the same direction. Previously, astronomers using an ESO telescope had shown that the star harbours a planet, more than 2 times as large as Jupiter and orbiting in 320 days (ESO 12/99). But until now, all studies were unable to pinpoint the exact characteristics of the star, and hence to understand its origin. A team of astronomers, led by Sylvie Vauclair from the University of Toulouse, France, therefore decided to use the technique of 'asteroseismology' to unlock the star's secrets. "In the same way as geologists monitor how seismic waves generated by earthquakes propagate through the Earth and learn about the inner structure of our planet, it is possible to study sound waves running through a star, which forms a sort of large, spherical bell," says Vauclair. The 'ringing' from this giant musical instrument provides astronomers with plenty of information about the physical conditions in the star's interior. And to 'listen to the music', the astronomers used one of the best instruments available. The observations were conducted in November 2006 during 8 consecutive nights with the state-of-the-art HARPS spectrograph mounted on the ESO 3.6-m telescope at La Silla. Up to 25 'notes' could be identified in the unique dataset, most of them corresponding to waves having a period of about 6.5 minutes. These observations allowed the astronomers to obtain a very precise portrait of Iota Horologii: its

Prion Propagation in Cells Expressing PrP Glycosylation Mutants ▿

Science.gov (United States)

Salamat, Muhammad K.; Dron, Michel; Chapuis, Jérôme; Langevin, Christelle; Laude, Hubert

2011-01-01

Infection by prions involves conversion of a host-encoded cell surface protein (PrPC) to a disease-related isoform (PrPSc). PrPC carries two glycosylation sites variably occupied by complex N-glycans, which have been suggested by previous studies to influence the susceptibility to these diseases and to determine characteristics of prion strains. We used the Rov cell system, which is susceptible to sheep prions, to generate a series of PrPC glycosylation mutants with mutations at one or both attachment sites. We examined their subcellular trafficking and ability to convert into PrPSc and to sustain stable prion propagation in the absence of wild-type PrP. The susceptibility to infection of mutants monoglycosylated at either site differed dramatically depending on the amino acid substitution. Aglycosylated double mutants showed overaccumulation in the Golgi compartment and failed to be infected. Introduction of an ectopic glycosylation site near the N terminus fully restored cell surface expression of PrP but not convertibility into PrPSc, while PrPC with three glycosylation sites conferred cell permissiveness to infection similarly to the wild type. In contrast, predominantly aglycosylated molecules with nonmutated N-glycosylation sequons, produced in cells expressing glycosylphosphatidylinositol-anchorless PrPC, were able to form infectious PrPSc. Together our findings suggest that glycosylation is important for efficient trafficking of anchored PrP to the cell surface and sustained prion propagation. However, properly trafficked glycosylation mutants were not necessarily prone to conversion, thus making it difficult in such studies to discern whether the amino acid changes or glycan chain removal most influences the permissiveness to prion infection. PMID:21248032

Glycan-deficient PrP stimulates VEGFR2 signaling via glycosaminoglycan.

Science.gov (United States)

Gao, Zhenxing; Zhang, Huixia; Hu, Fei; Yang, Liheng; Yang, Xiaowen; Zhu, Ying; Sy, Man-Sun; Li, Chaoyang

2016-06-01

Whether the two N-linked glycans are important in prion, PrP, biology is unresolved. In Chinese hamster ovary (CHO) cells, the two glycans are clearly not important in the cell surface expression of transfected human PrP. Compared to fully-glycosylated PrP, glycan-deficient PrP preferentially partitions to lipid raft. In CHO cells glycan-deficient PrP also interacts with glycosaminoglycan (GAG) and vascular endothelial growth factor receptor 2 (VEGFR2), resulting in VEGFR2 activation and enhanced Akt phosphorylation. Accordingly, CHO cells expressing glycan-deficient PrP lacking the GAG binding motif or cells treated with heparinase to remove GAG show diminished Akt signaling. Being in lipid raft is critical, chimeric glycan-deficient PrP with CD4 transmembrane and cytoplasmic domains is absent in lipid raft and does not activate Akt signaling. CHO cells bearing glycan-deficient PrP also exhibit enhanced cellular adhesion and migration. Based on these findings, we propose a model in which glycan-deficient PrP, GAG, and VEGFR2 interact, activating VEGFR2 and resulting in changes in cellular behavior. Copyright © 2016 Elsevier Inc. All rights reserved.

Pathogenesis of PR3-ANCA associated vasculitis

NARCIS (Netherlands)

Kallenberg, C. G. M.

2008-01-01

Wegener's Granulomatosis (WG) is closely associated with antineutrophil cytoplasmic autoantibodies (ANCA), particularly those directed to proteinase 3 (PR3). ANCA directed to myeloperoxidase (MPO) are associated with microscopic polyangiitis (MPA) and the Churg Strauss syndrome. PR3-ANCA associated

A Tale of Two Populations

Science.gov (United States)

2005-03-01

ESO PR Photo 08a/05 ESO PR Photo 08a/05 The Omega Centauri Globular Cluster and the Area Surveyed [Preview - JPEG: 400 x 704 pix - 73k] [Normal - JPEG: 800 x 1408 pix - 750k] [HiRes - JPEG: 1875 x 3300 pix - 3.5M] Caption: ESO PR Photo 08a/05 shows an image of the Omega Centauri globular cluster from the the Digital Sky Survey (left). The image covers a region of 2.1 x 1.1 degrees on the sky, illustrating the very large extent of this cluster of stars. The right image is the ACS exposure taken with the Hubble Space Telescope which the astronomers used to detect and study the two distinct populations of hydrogen core-burning stars. The position of the ACS field with respect to the full globular cluster is shown as the red box. This field was chosen to lie in the outskirts of the cluster in order to ensure that there won't be any "crowding" problems and that there would be only one star in each FLAMES/VLT fiber. ESO PR Photo 08b/05 ESO PR Photo 08b/05 The Double Main Sequence of Omega Centauri [Preview - JPEG: 400 x 484 pix - 35k] [Normal - JPEG: 800 x 967 pix - 289k] [Full Res - JPEG: 2392 x 2890 pix - 1.6M] Caption: ESO PR Photo 08b/05 shows the two distinct populations of stars present in the globular cluster Omega Centauri, recognisable in this colour-brightness diagram that is based on data obtained via the HST image shown in ESO PR photo 08a/05. The stars coloured in blue and in red are those for which a spectrum was acquired with the VLT. Globular clusters are large stellar clusters some of which contain hundreds of thousands of stars. It is generally believed that all stars belonging to the same globular cluster were born together, from the same interstellar cloud and at the same time. Strangely, however, this seems not to be the case for the large southern globular cluster Omega Centauri. Omega Centauri is the galactic globular cluster with the most complex stellar population. Its large mass may represent an intermediate type of object, between globular

Second Announcement - ESO/ST-ECF Workshop on NICMOS and the VLT: A New Era of High-Resolution Near-Infrared Imaging and Spectroscopy - May 26-27, 1998 - Hotel Baia di Nora, Pula, Sardinia, Italy

Science.gov (United States)

1998-03-01

ST-ECF and ESO are organising in collaboration with the NICMOS IDT and STScI a workshop on near infrared imaging from space and ground. The purpose of the workshop is to review what has been achieved with the Near Infrared and Multi Object Spectrograph (NICMOS) on board of HST, what can be achieved in the remaining lifetime of the instrument, and how NICMOS observations can be optimised taking into account the availability of IR imaging and spectroscopy on ESO's Very large Telescope (VLT) in the near future. The meeting will be held in May 1998, about one year after science observations started with NICMOS, and about half a year before the Infrared Spectrometer and Array Camera (ISAAC) starts to operate on the VLT. Currently, it is expected that NICMOS will operate until the end of 1998.

Estudio sobre la evolución de los modelos mentales de estudiantes de 4º de ESO cuando observan, reflexionan y discuten sobre la combustión

Directory of Open Access Journals (Sweden)

Vanessa Sesto

2017-01-01

Full Text Available El propósito de este estudio fue analizar la evolución de los modelos mentales de estudiantes de secundaria sobre fenómenos que implican cambios en la materia al tener la oportunidad de observar, reflexionar y discutir sobre ellos. En trabajos anteriores ya se han identificado los modelos de los estudiantes sobre esta temática; sin embargo, aún se tiene poco conocimiento de cómo esos modelos evolucionan con la interacción social. Para alcanzar este objetivo se propuso como actividad la combustión de una vela dentro de un recipiente de cristal. Los participantes eran ocho estudiantes de 4º de ESO. La recogida de datos se realizó por medio de cuestionarios y grabaciones en audio y vídeo al realizar la actividad en pequeño grupo. Los resultados muestran una cierta evolución en los modelos. Al principio, los estudiantes utilizan los modelos de desaparición y transmutación. Después de la discusión, algunos estudiantes ya utilizan el modelo de reacción química.

Comparative NMR study of nPrBTP and iPrBTP

Energy Technology Data Exchange (ETDEWEB)

Adam, C.; Muellich, U.; Geist, A.; Geckeis, H. [Karlsruhe Institute of Technology - KIT, Institute for Nuclear Waste Disposal - INE, Herrmann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen (Germany); Rohde, V. [Fraunhofer Institute for Chemical Technology - ICT, Environmental Engineering, Joseph-von-Fraunhofer-Str. 7, 76327 Pfinztal (Germany); Kaden, P. [Helmholtz-Zentrum Dresden - Rossendorf e. V., Institute of Resource Ecology, Bautzner Landstrasse 400, 01328 Dresden (Germany); Panak, P.J. [Karlsruhe Institute of Technology - KIT, Institute for Nuclear Waste Disposal - INE, Herrmann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen (Germany); University of Heidelberg, Department of Physical Chemistry, Im Neuenheimer Feld 253, 69120 Heidelberg (Germany)

2016-07-01

Bis-triazinyl-pyridine type ligands are important extracting agents for separating trivalent actinide ions from trivalent lanthanides. The alkyl substituents on the lateral triazine rings have a significant effect on the stability of the ligand against hydrolysis and radiolysis. Furthermore they influence solubility, extraction behaviour and selectivity. TRLFS and extraction studies suggest differences in complexation and extraction behaviour of BTP ligands bearing iso-propyl or n-propyl substituents, respectively. As NMR studies allow insight into the metal-ligand bonding, we conducted NMR studies on a range of {sup 15}N-labelled nPrBTP and iPrBTP Ln(III) and Am(III) complexes. Our results show that no strong change in the metal-ligand bonding occurs, thus excluding electronic reasons for differences in complexation behaviour, extraction kinetics and selectivity. This supports mechanistic reasons for the observed differences. (authors)

Advancing tendencies? PR leadership, general leadership, and leadership pedagogy

OpenAIRE

McKie, D; Willis, P

2014-01-01

What are the best ways to advance PR leadership? In exploring answers, we consider the last two decades of PR literature and identify two main tendencies. We link those two with general leadership literature and practices, as well as with literature on leadership pedagogy. We conclude that, rather than recent moves to look within the field, without self-reflection, to existing PR perspectives and figures for solutions, looking outwards has greater potential to transform not only the PR leader...

Ten years experience of PR

International Nuclear Information System (INIS)

Dobak, Dobroslav

2002-01-01

This paper is an effort to summarize the way Slovak Bohunice NPP has gone through since the historical change in the Middle and Eastern European countries. Milestones on the way were: 1989 - change of political system; increasing interest of the public appearance; creation of work capacities - personnel and technical; education/exchange with Western countries; 1994 - establishment of Foreign Affairs and PR Department reporting directly to the NPP manager; application of various approaches, some observed from other countries; creation of utility policy - place of PR in the company; establishment of QA system - description of PR activities, goals, interlinks etc.; annual planning process including activities, finance, education (training). Lessons learned are: the NPP managers were not prepared; the public was not (and still is not) prepared to obtain specific information; education is crucial in opinion winning; simple overtake of methods from others is not always applicable; strategy and feedback are necessary. Special case was the early closure Bohunice V1 NPP

A phase I trial of PR-104, a pre-prodrug of the bioreductive prodrug PR-104A, given weekly to solid tumour patients

International Nuclear Information System (INIS)

McKeage, Mark J; Gu, Yongchuan; Wilson, William R; Hill, Andrew; Amies, Karen; Melink, Teresa J; Jameson, Michael B

2011-01-01

The phosphate ester PR-104 is rapidly converted in vivo to the alcohol PR-104A, a nitrogen mustard prodrug that is metabolised to hydroxylamine (PR-104H) and amine (PR-104M) DNA crosslinking agents by one-electron reductases in hypoxic cells and by aldo-keto reductase 1C3 independently of oxygen. In a previous phase I study using a q 3 week schedule of PR-104, the maximum tolerated dose (MTD) was 1100 mg/m 2 and fatigue, neutropenic fever and infection were dose-limiting. The primary objective of the current study was to determine the dose-limiting toxicity (DLT) and MTD of weekly PR-104. Patients with advanced solid tumours received PR-104 as a 1-hour intravenous infusion on days 1, 8 and 15 every 28 days with assessment of pharmacokinetics on cycle 1 day 1. Twenty-six patients (pts) were enrolled (16 male/10 female; median age 58 yrs, range 30 to 70 yrs) who had received a median of two prior chemotherapy regimens (range, 0 to 3) for melanoma (8 pts), colorectal or anal cancer (3 pts), NSCLC (3 pts), sarcoma (3 pts), glioblastoma (2 pts), salivary gland tumours (2 pts) or other solid tumours (5 pts). PR-104 was administered at 135 mg/m 2 (3 pts), 270 mg/m 2 (6 pts), 540 mg/m 2 (6 pts), 675 mg/m 2 (7 pts) and 900 mg/m 2 (4 pts) for a median of two treatment cycles (range, 1 to 7 cycles) and five infusions (range, 1 to 18) per patient. Dose-limiting toxicities (DLTs) during cycle one included grade four thrombocytopenia at 540 mg/m 2 (1 of 6 pts) and grade four thrombocytopenia and neutropenia at 900 mg/m 2 (2 of 4 pts). At an intermediate dose of 675 mg/m 2 , there were no DLTs among a total of seven patients given 12 treatment cycles but all experienced moderate to severe (grade 2 to 4) haematological toxicity. Thrombocytopenia was delayed in its onset and nadir, and its recovery was protracted and incomplete in many patients. There were no complete or partial tumour responses. PR-104-induced thrombocytopenia and neutropenia correlated with plasma AUC of PR-104

Automated data reduction workflows for astronomy. The ESO Reflex environment

Science.gov (United States)

Freudling, W.; Romaniello, M.; Bramich, D. M.; Ballester, P.; Forchi, V.; García-Dabló, C. E.; Moehler, S.; Neeser, M. J.

2013-11-01

Context. Data from complex modern astronomical instruments often consist of a large number of different science and calibration files, and their reduction requires a variety of software tools. The execution chain of the tools represents a complex workflow that needs to be tuned and supervised, often by individual researchers that are not necessarily experts for any specific instrument. Aims: The efficiency of data reduction can be improved by using automatic workflows to organise data and execute a sequence of data reduction steps. To realize such efficiency gains, we designed a system that allows intuitive representation, execution and modification of the data reduction workflow, and has facilities for inspection and interaction with the data. Methods: The European Southern Observatory (ESO) has developed Reflex, an environment to automate data reduction workflows. Reflex is implemented as a package of customized components for the Kepler workflow engine. Kepler provides the graphical user interface to create an executable flowchart-like representation of the data reduction process. Key features of Reflex are a rule-based data organiser, infrastructure to re-use results, thorough book-keeping, data progeny tracking, interactive user interfaces, and a novel concept to exploit information created during data organisation for the workflow execution. Results: Automated workflows can greatly increase the efficiency of astronomical data reduction. In Reflex, workflows can be run non-interactively as a first step. Subsequent optimization can then be carried out while transparently re-using all unchanged intermediate products. We found that such workflows enable the reduction of complex data by non-expert users and minimizes mistakes due to book-keeping errors. Conclusions: Reflex includes novel concepts to increase the efficiency of astronomical data processing. While Reflex is a specific implementation of astronomical scientific workflows within the Kepler workflow

Genetic determinants of P wave duration and PR segment

NARCIS (Netherlands)

Verweij, Niek; Mateo Leach, Irene; van den Boogaard, Malou; van Veldhuisen, Dirk J.; Christoffels, Vincent M.; Hillege, Hans L.; van Gilst, Wiek H.; Barnett, Phil; de Boer, Rudolf A.; van der Harst, Pim

2014-01-01

The PR interval on the ECG reflects atrial depolarization and atrioventricular nodal delay which can be partially differentiated by P wave duration and PR segment, respectively. Genome-wide association studies have identified several genetic loci for PR interval, but it remains to be determined

Genetic Determinants of P Wave Duration and PR Segment

NARCIS (Netherlands)

Verweij, Niek; Mateo Leach, Irene; van den Boogaard, Malou; van Veldhuisen, Dirk J.; Christoffels, Vincent M.; Hillege, Hans L.; van Gilst, Wiek H.; Barnett, Phil; de Boer, Rudolf A.; van der Harst, Pim

Background-The PR interval on the ECG reflects atrial depolarization and atrioventricular nodal delay which can be partially differentiated by P wave duration and PR segment, respectively. Genome-wide association studies have identified several genetic loci for PR interval, but it remains to be

Antimicrobial and immunomodulatory activities of PR-39 derived peptides.

Directory of Open Access Journals (Sweden)

Edwin J A Veldhuizen

Full Text Available The porcine cathelicidin PR-39 is a host defence peptide that plays a pivotal role in the innate immune defence of the pig against infections. Besides direct antimicrobial activity, it is involved in immunomodulation, wound healing and several other biological processes. In this study, the antimicrobial- and immunomodulatory activity of PR-39, and N- and C-terminal derivatives of PR-39 were tested. PR-39 exhibited an unexpected broad antimicrobial spectrum including several Gram positive strains such as Bacillus globigii and Enterococcus faecalis. Of organisms tested, only Staphylococcus aureus was insensitive to PR-39. Truncation of PR-39 down to 15 (N-terminal amino acids did not lead to major loss of activity, while peptides corresponding to the C-terminal part of PR-39 were hampered in their antimicrobial activity. However, shorter peptides were all much more sensitive to inhibition by salt. Active peptides induced ATP leakage and loss of membrane potential in Bacillus globigii and Escherichia coli, indicating a lytic mechanism of action for these peptides. Finally, only the mature peptide was able to induce IL-8 production in porcine macrophages, but some shorter peptides also had an effect on TNF-α production showing differential regulation of cytokine induction by PR-39 derived peptides. None of the active peptides showed high cytotoxicity highlighting the potential of these peptides for use as an alternative to antibiotics.

Antimicrobial and Immunomodulatory Activities of PR-39 Derived Peptides

Science.gov (United States)

Veldhuizen, Edwin J. A.; Schneider, Viktoria A. F.; Agustiandari, Herfita; van Dijk, Albert; Tjeerdsma-van Bokhoven, Johanna L. M.; Bikker, Floris J.; Haagsman, Henk P.

2014-01-01

The porcine cathelicidin PR-39 is a host defence peptide that plays a pivotal role in the innate immune defence of the pig against infections. Besides direct antimicrobial activity, it is involved in immunomodulation, wound healing and several other biological processes. In this study, the antimicrobial- and immunomodulatory activity of PR-39, and N- and C-terminal derivatives of PR-39 were tested. PR-39 exhibited an unexpected broad antimicrobial spectrum including several Gram positive strains such as Bacillus globigii and Enterococcus faecalis. Of organisms tested, only Staphylococcus aureus was insensitive to PR-39. Truncation of PR-39 down to 15 (N-terminal) amino acids did not lead to major loss of activity, while peptides corresponding to the C-terminal part of PR-39 were hampered in their antimicrobial activity. However, shorter peptides were all much more sensitive to inhibition by salt. Active peptides induced ATP leakage and loss of membrane potential in Bacillus globigii and Escherichia coli, indicating a lytic mechanism of action for these peptides. Finally, only the mature peptide was able to induce IL-8 production in porcine macrophages, but some shorter peptides also had an effect on TNF-α production showing differential regulation of cytokine induction by PR-39 derived peptides. None of the active peptides showed high cytotoxicity highlighting the potential of these peptides for use as an alternative to antibiotics. PMID:24755622

Programa Pró-Letramento : interface entre formação continuada, prática docente e ensino da leitura

OpenAIRE

Lúcia da Silva Cabral, Maria

2009-01-01

Essa pesquisa visa analisar os impactos da Formação Continuada na prática docente dos professores das séries iniciais do Ensino Fundamental no eixo do ensino da leitura, no Programa Pró-Letramento Alfabetização e Linguagem. Para realizar, então, esta investigação qualitativa, observamos os processos de Formação Continuada dos orientadores de estudos e também dos professores no programa mencionado. Realizamos também observação da prática de duas professoras em turmas iniciais ...

A Forceful Demonstration by FORS

Science.gov (United States)

1998-09-01

.). In addition, detailed computer software was provided to prepare the complex astronomical observations with FORS in advance and to monitor the instrument performance by quality checks of the scientific data accumulated. In return for building FORS for the community of European astrophysicists, the scientists in the three institutions of the FORS Consortium have received a certain amount of Guaranteed Observing Time at the VLT. This time will be used for various research projects concerned, among others, with minor bodies in the outer solar system, stars at late stages of their evolution and the clouds of gas they eject, as well as galaxies and quasars at very large distances, thereby permitting a look-back towards the early epoch of the universe. First tests of FORS1 at the VLT UT1: a great success After careful preparation, the FORS consortium has now started the so-called commissioning of the instrument. This comprises the thorough verification of the specified instrument properties at the telescope, checking the correct functioning under software control from the Paranal control room and, at the end of this process, a demonstration that the instrument fulfills its scientific purpose as planned. While performing these tests, the commissioning team at Paranal were able to obtain images of various astronomical objects, some of which are shown here. Two of these were obtained on the night of "FORS First Light". The photos demonstrate some of the impressive posibilities with this new instrument. They are based on observations with the FORS standard resolution collimator (field size 6.8 x 6.8 armin = 2048 x 2048 pixels; 1 pixel = 0.20 arcsec). Spiral galaxy NGC 1288 ESO PR Photo 37a/98 ESO PR Photo 37a/98 [Preview - JPEG: 800 x 908 pix - 224k] [High-Res - JPEG: 3000 x 3406 pix - 1.5Mb] A colour image of spiral galaxy NGC 1288, obtained on the night of "FORS First Light". The first photo shows a reproduction of a colour composite image of the beautiful spiral galaxy NGC

Desnutrição e práticas pré-escolares de leitura e escrita

Directory of Open Access Journals (Sweden)

Sandra Maria Sawaya

2013-01-01

Full Text Available O presente artigo procura dar conta de alguns dos resultados de uma pesquisa realizada com um grupo de treze crianças de três a cinco anos em uma instituição de educação infantil que atende crianças com desnutrição primária. Um dos objetivos do estudo foi verificar que relações e práticas de leitura e escrita se desenvolvem entre esse grupo de crianças e seu professor na pré-escola. Os dados obtidos corroboram estudos que apontam a necessidade de revisar os pressupostos das políticas educacionais de que as crianças de camadas populares trazem para a instituição de ensino problemas de aprendizagem devido a atrasos no desenvolvimento linguístico e cognitivo em decorrência da ausência de práticas de leitura e escrita em seu universo sociocultural.

Aprendizagem como/na prática

Directory of Open Access Journals (Sweden)

Jean Lave

2015-12-01

Full Text Available ResumoEste artigo considera como o estudo da cultura e da aprendizagem pode ser de particular relevância para o campo da antropologia sociocultural em geral. O termo mais importante na expressão “cultura & aprendizagem” talvez seja o logograma “&” – ou seja, coloca-se a questão sobre o que conecta cultura e aprendizagem, perguntando-se como esses termos estão relacionados. Como devemos compreender cultura e aprendizagem como instâncias produtoras delas próprias, e uma da outra, na prática? Recalibrando em termos relacionais, podemos dizer que não é possível abordar a “aprendizagem” ou “cultura e aprendizagem” sem o seu emaranhamento na vida político-econômica, nas lutas e disputas históricas, em suas coerências e incoerências, e na produção relacional e histórica da vida cotidiana. Através das lentes da teoria da prática social, os estudos etnográficos sobre aprendizagem na prática oferecem diferentes entendimentos sobre como certa vida e certas disputas e incoerências são produzidas.

Prôtegis data

Directory of Open Access Journals (Sweden)

María Fernanda De la Ossa Archila

2013-12-01

Full Text Available El suministro de datos personales por los particulares se realiza casi a diario, por lo que es básico conocer quién tiene esos datos, cuáles son las medidas que adopta este sujeto para que dichos datos sean utilizados de manera correcta y para unos fines precisos para los cuales se han suministrado. La pregunta concreta que debe uno formularse es cómo se protegen los datos personales. Teniendo en cuenta lo anterior, en este artículo se hará un recuento de lo que ocurre en el contexto colombiano, en donde el legislador, por medio de la Ley 1581 de 2012 que fue sometida a control previo de constitucionalidad, reguló los derechos de los titulares de la información, los deberes de los responsables y encargados del tratamiento de la información suministrada y señaló de manera concreta cuál es la autoridad encargada para la vigilancia y control de una efectiva protección de los datos personales.

Interferon-Stimulated Genes Are Transcriptionally Repressed by PR in Breast Cancer.

Science.gov (United States)

Walter, Katherine R; Goodman, Merit L; Singhal, Hari; Hall, Jade A; Li, Tianbao; Holloran, Sean M; Trinca, Gloria M; Gibson, Katelin A; Jin, Victor X; Greene, Geoffrey L; Hagan, Christy R

2017-10-01

The progesterone receptor (PR) regulates transcriptional programs that drive proliferation, survival, and stem cell phenotypes. Although the role of native progesterone in the development of breast cancer remains controversial, PR clearly alters the transcriptome in breast tumors. This study identifies a class of genes, Interferon (IFN)-stimulated genes (ISGs), potently downregulated by ligand-activated PR which have not been previously shown to be regulated by PR. Progestin-dependent transcriptional repression of ISGs was observed in breast cancer cell line models and human breast tumors. Ligand-independent regulation of ISGs was also observed, as basal transcript levels were markedly higher in cells with PR knockdown. PR repressed ISG transcription in response to IFN treatment, the canonical mechanism through which these genes are activated. Liganded PR is robustly recruited to enhancer regions of ISGs, and ISG transcriptional repression is dependent upon PR's ability to bind DNA. In response to PR activation, key regulatory transcription factors that are required for IFN-activated ISG transcription, STAT2 and IRF9, exhibit impaired recruitment to ISG promoter regions, correlating with PR/ligand-dependent ISG transcriptional repression. IFN activation is a critical early step in nascent tumor recognition and destruction through immunosurveillance. As the large majority of breast tumors are PR positive at the time of diagnosis, PR-dependent downregulation of IFN signaling may be a mechanism through which early PR-positive breast tumors evade the immune system and develop into clinically relevant tumors. Implications: This study highlights a novel transcriptional mechanism through which PR drives breast cancer development and potentially evades the immune system. Mol Cancer Res; 15(10); 1331-40. ©2017 AACR . ©2017 American Association for Cancer Research.

O sentido objetivo da prática administrativa

Directory of Open Access Journals (Sweden)

Paulo Tromboni Nascimento

Full Text Available Este artigo examina o sentido da prática administrativa e defende a tese de que é objetivo. A discussão busca a caracterização geral do objeto de investigação. No lugar do objeto das ciências da natureza, inanimado e isolado do sujeito, entra a prática administrativa com sentido objetivo derivado da lógica da situação objetiva do administrador no contexto organizacional. Vale dizer derivado dos propósitos, da rede estruturada de relações sociais e do sistema de práticas da organização. O que torna real a sua axiologia referenciada na eficiência e eficácia da ação, além de fazer da prática administrativa um fator de regulação e mudança controlada da organização. Examinar cientificamente uma prática é criar as condições para mudá-la via uma dialética da descrição, explicação e prescrição. A filosofia da prática é proposta como pressuposto geral da pesquisa científica em administração.

The PR in PN for Education Associations. PR Bookshelf, No. 3.

Science.gov (United States)

National Education Association, Washington, DC.

This booklet presents suggestions and guidelines for the effective use of public relations (PR) techniques during professional negotiations (PN) among teachers, administrators, and boards of education. Introductory sections present the National Education Association (NEA) position regarding professional negotiation and grievance procedures and…

A leitura como prática de (resocialização no Sistema Penitenciário Nacional

Directory of Open Access Journals (Sweden)

Marcio José de Lima Winchuar

2017-08-01

, realizamos una investigación en el banco de disertaciones y tesis del Portal da Capes y en la Biblioteca Digital Brasileña de Tesis y Disertaciones. A partir del levantamiento de datos, identificamos que trabajos que involucran la educación en el sistema penitenciario aún son pocos, principalmente, relacionados a prácticas de lectura. Esa situación puede agravarse, sobretodo, por la pseudoefectivación de políticas que rigen esos contextos. Palabras clave: Lectura. Sistema Penitencioario. Humanización.

Low fraction of the 222K PrP variant in the protease-resistant moiety of PrPres in heterozygous scrapie positive goats.

Science.gov (United States)

Mazza, Maria; Guglielmetti, Chiara; Ingravalle, Francesco; Brusadore, Sonia; Langeveld, Jan P M; Ekateriniadou, Loukia V; Andréoletti, Olivier; Casalone, Cristina; Acutis, Pier Luigi

2017-07-01

The presence of lysine (K) at codon 222 has been associated with resistance to classical scrapie in goats, but few scrapie cases have been identified in 222Q/K animals. To investigate the contribution of the 222K variant to PrPres formation in natural and experimental Q/K scrapie cases, we applied an immunoblotting method based on the use of two different monoclonal antibodies, F99/97.6.1 and SAF84, chosen for their different affinities to 222K and 222Q PrP variants. Our finding that PrPres seems to be formed nearly totally by the 222Q variant provides evidence that the 222K PrP variant confers resistance to conversion to PrPres formation and reinforces the view that this mutation has a protective role against classical scrapie in goats.

Solid state synthesis, characterization, surface and catalytic properties of Pr2CoO4 and Pr2NiO4 catalyst

International Nuclear Information System (INIS)

Sinha, K.K.; Indu, N.K.; Sinha, S.K.; Pankaj, A.K.

2008-01-01

Full text: The most interesting non-stoichiometric oxides are found in transition metal and rare earth oxides at higher temperatures. The role of Solid State properties in the catalysis using mixed metal oxide as catalyst have wide applications in fertilizer, Petro-chemical, Pharmaceutical, cosmetic, paint detergents, plastics and food-stuff industries and these are also resistive towards acids and alkalies. The use of catalyst has opened up new process routes or revolutioned the existing process in terms of economics and efficiency and has radically changed the industrial scenario. The use of catalyst is so pervasive today that nearly 70 % of modern chemical processes are based on it at some stage or other and 90% new processes developed are catalytic nature. A series of non-stoichiometric spinel type of oxide catalyst of Praseodymium with cobalt and nickel were synthesized by their oxalates through Solid State reaction technique at different activation temperatures i.e. 600, 700, 800 and 900 deg C. The characterization of catalyst was done by XRD, FTIR and ESR methods. X-ray powder diffraction study shows that catalysts are made up of well grown crystallinities mostly in single phase crystal and system is of orthorhombic structure. FTIR is related to inadequate decomposition of oxalate ion from the Catalyst. The kinetic decomposition of Urea was employed as a model reaction to study the catalytic potentiality of different catalysts. Surface and Catalytic Properties of catalysts were measured. A relation between activation temperature and surface properties like excess surface oxygen (E.S.O.), surface acidity and surface area was observed. A linear relationship between the surface area of the catalyst and the amount of ammonia gas evolved per gm of the sample was observed also. Nickel containing catalysts were found a bit more catalytic active in comparison to cobalt oxide catalysts. Transition metal ions (i.e. Ni 2+ and Co 2+ ions) are mainly responsible for

PrEP implementation research in Africa: what is new?

Science.gov (United States)

Cowan, Frances M; Delany-Moretlwe, Sinead; Sanders, Eduard J; Mugo, Nelly R; Guedou, Fernand A; Alary, Michel; Behanzin, Luc; Mugurungi, Owen; Bekker, Linda-Gail

2016-01-01

Of the two million new HIV infections in adults in 2014, 70% occurred in sub-Saharan Africa. Several African countries have already approved guidelines for pre-exposure prophylaxis (PrEP) for individuals at substantial risk of HIV as part of combination HIV prevention but key questions remain about how to identify and deliver PrEP to those at greatest need. Throughout the continent, individuals in sero-discordant relationships, and members of key populations (sex workers, men who have sex with men (MSM), transgender women and injection drug users) are likely to benefit from the availability of PrEP. In addition, adolescent girls and young women (AGYW) are at substantial risk in some parts of the continent. It has been estimated that at least three million individuals in Africa are likely to be eligible for PrEP according to WHO's criteria. Tens of demonstration projects are planned or underway across the continent among a range of countries, populations and delivery settings. In each of the target populations, there are overarching issues related to (i) creating demand for PrEP, (ii) addressing supply-side issues and (iii) providing appropriate and tailored adherence support. Critical for creating demand for PrEP is the normalization of HIV prevention. Community-level interventions which engage opinion leaders as well as empowerment interventions for those at highest risk will be key. Critical to supply of PrEP is that services are accessible for all, including for stigmatized populations. Establishing accessible integrated services provides the opportunity to address other public health priorities including the unmet need for HIV testing, contraception and sexually transmitted infections treatment. National policies need to include minimum standards for training and quality assurance for PrEP implementation and to address supply chain issues. Adherence support needs to recognize that social and structural factors are likely to have an important influence

A Closer Look at Racism and Heterosexism in Medical Students' Clinical Decision-Making Related to HIV Pre-Exposure Prophylaxis (PrEP): Implications for PrEP Education.

Science.gov (United States)

Calabrese, Sarah K; Earnshaw, Valerie A; Krakower, Douglas S; Underhill, Kristen; Vincent, Wilson; Magnus, Manya; Hansen, Nathan B; Kershaw, Trace S; Mayer, Kenneth H; Betancourt, Joseph R; Dovidio, John F

2018-04-01

Social biases among healthcare providers could limit PrEP access. In this survey study of 115 US medical students, we examined associations between biases (racism and heterosexism) and PrEP clinical decision-making and explored prior PrEP education as a potential buffer. After viewing a vignette about a PrEP-seeking MSM patient, participants reported anticipated patient behavior (condomless sex, extra-relational sex, and adherence), intention to prescribe PrEP to the patient, biases, and background characteristics. Minimal evidence for racism affecting clinical decision-making emerged. In unadjusted analyses, heterosexism indirectly affected prescribing intention via all anticipated behaviors, tested as parallel mediators. Participants expressing greater heterosexism more strongly anticipated increased risk behavior and adherence problems, which were associated with lower prescribing intention. The indirect effect via condomless sex remained significant adjusting for background characteristics. Prior PrEP education did not buffer any indirect effects. Heterosexism may compromise PrEP provision to MSM and should be addressed in PrEP-related medical education.

Research into the evaluation of PR activities in companies from Serbia

Directory of Open Access Journals (Sweden)

Milan Nikolic

2016-04-01

Full Text Available This paper presents the results of a research into the volume, type and quality of the evaluation of public relations activities in companies in Serbia. The survey was conducted via a web survey. The responses were collected from 50 PR service managers from 50 companies in Serbia. The results are presented through descriptive statistics and correlation analysis where some of the observed sizes of the connection were analyzed. The main conclusions can be summarized as follows: PR functions are often not assigned sufficient importance in companies in Serbia; the evaluation of PR activity is slightly neglected compared to other PR activities; intensive and continuous evaluation of the performances of PR activities increases the likelihood of the complete PR function of the company being successful; companies that are not so successful use evaluation less than successful companies; the evaluation of PR activities is mostly done through a method for measuring quantity; the main problems in the evaluation of PR activities are lack of time and money. The evaluation of PR activities in companies in Serbia can be improved through a greater understanding on the part of top managers, and also by hiring additional PR practitioners.

Paramagnetic probes to study PrNi5?

International Nuclear Information System (INIS)

Hutchinson, W.D.; Harker, S.J.; Stewart, G.A.; Chaplin, D.H.; Kaplan, N.

1996-01-01

The Van-Vleck paramagnet PrNi 5 has been the focus of many studies in the past as a result of its usefulness as a nuclear cooling agent. Extensive continuous wave praseodymium NMR measurements have been carried out on this compound. However pulsed NMR and therefore precise relaxation measurements particularly at mK temperatures have proved elusive. In this work we have proposed to use radiative gamma-ray detection to indirectly measure Pr NMR in PrNi 5 via cross relaxation to suitable paramagnetic impurity probes placed at Ni lattice sites. 57 Co was chosen as the most compatible nuclear orientation isotope with an appropriate nuclear g-factor. The choice of 57 Co also allows the use of Moessbauer spectroscopy to check the site occupancy. This poster details the production of a 57 Co doped PrNi 5 single crystal specimen including the specimen preparation problems encountered, 57 Fe Moessbauer and preliminary nuclear orientation measurements

Los riesgos para los niños que usan internet

Directory of Open Access Journals (Sweden)

Instituto Argentino de Computación IAC

2015-01-01

Full Text Available Los niños que navegan por Internet pueden ser víctimas de hechos criminales, explotación y pornografía. No hay restricciones para publicar cualquier material por eso es responsabilidad de padres y maestros, así como personal la responsabilidad de asegurarse que los sitios de Internet sean seguros y apropiados. Relata los riesgos que existen, da consejos prácticos a los padres y reglas familiares porque no resulta práctico prohibirles a los niños el uso del Internet.

Luminescence of the SrCl2:Pr crystals under high-energy excitation

International Nuclear Information System (INIS)

Antonyak, O.T.; Voloshinovskii, A.S.; Vistovskyy, V.V.; Stryganyuk, G.B.; Kregel, O.P.

2014-01-01

The present research was carried out in order to elucidate the mechanisms of energy transfer from the crystal lattice to Pr 3+ ions in SrCl 2 . The luminescence excitation and emission spectra as well as luminescence kinetics of the SrCl 2 :Pr single crystals containing 0.2 mol% Pr were investigated at 300 and 10 K using the vacuum ultraviolet (VUV) synchrotron radiation. The X-ray excited luminescence spectra of the SrCl 2 :Pr (C Pr =0.2 and 0.5 mol%) and SrCl 2 :Pr, K (C Pr =1.5 mol%; C K =1.5 mol%) crystals were studied at 294 and 80 K. Under optical excitation of the samples in the Pr 3+ absorption bands, there were observed five fast ultraviolet emissions assigned to the 4f 1 5d→4f 2 transitions, and two long-wave bands corresponding to the f–f transitions. Furthermore, the intrinsic emission bands of SrCl 2 were observed at 10 K. The X-ray excited luminescence spectrum of the SrCl 2 :Pr crystal containing 0.2 mol% Pr, besides intrinsic emission band near 400 nm, has got a long-wave band at about 490 nm of the Pr 3+ centers. There were not observed any emission bands of the Pr 3+ centers corresponding to the 4f 1 5d–4f 2 transitions in the X-ray excited luminescence spectrum of the SrCl 2 :Pr crystal. The possible mechanisms of energy transfer from the SrCl 2 matrix to the Pr 3+ centers are discussed. -- Highlights: • Spectral-luminescent properties of SrCl 2 :Pr have been investigated. • The identification of emission 4f–4f and 5d–4f bands of Pr 3+ ions was performed. • Adding of potassium prevents clustering of the Pr 3+ centers in the SrCl 2 :Pr, K crystals. • Under X-ray excitation at 80–300 K only Pr 3+ 4f–4f and intrinsic emission is observed

Comparing the physical properties of Pr/Gd and Pr/Ce substitutions in Ru(Gd1.5Ce0.5)Sr2Cu2O10- δ

Science.gov (United States)

Khajehnezhad, A.; Nikseresht, N.; Hadipour, H.; Akhavan, M.

2008-06-01

We have compared the electrical and magnetic properties of Ru(Gd1.5- x Pr x )Ce0.5Sr2Cu2O10- δ (Pr/Gd samples) with x = 0.0, 0.01, 0.03, 0.033, 0.035, 0.04, 0.05, 0.06, 0.1 and RuGd1.5(Ce0.5- x Pr x ) Sr2 Cu2O10- δ (Pr/Ce samples) with x = 0.0, 0.01, 0.03, 0.05, 0.08, 0.1, 0.15, 0.2 prepared by the standard solid-state reaction technique. We obtained the XRD patterns for different samples with various x. The lattice parameters versus x for different substitutions have been obtained from Rietveld analysis. To determine how the magnetic and superconducting properties of these layered cuprate systems can be affected by Pr substitution, the resistivity, and magnetoresistivity, with H ext varying from 0.0 to 15 kOe, have been measured at various temperatures. Superconducting transition temperature T c and magnetic transition T irr , have been obtained through resistivity and ac susceptibility measurements. The T c suppression due to Pr/Gd and Pr/Ce substitutions show competition between pair breaking by magnetic impurities, hole doping due to different valances of ions, difference in ionic radii, and oxygen stoichiometry. Pr/Gd substitution suppresses superconductivity more rapidly than for Pr/Ce, showing that the effect of hole doping and magnetic impurity pair breaking is stronger than the difference in ionic radii. In Pr/Gd substitution, the small difference between the ionic radii of Pr3+,4+ and Gd3+, and absorption of more oxygen due to the higher valence of Pr with respect to Gd, decreases the mean Ru-Ru distance, and as a result, the magnetic exchange interaction becomes stronger with the increase of x. However, Pr/Ce substitution has the opposite effect. The magnetic parameters such as H c , obtained through magnetization measurements versus applied magnetic field isotherm at 77 K and room temperatures, become stronger with x in Pr/Gd and weaker with x in Pr/Ce substitution.

Early Delivery of Misfolded PrP from ER to Lysosomes by Autophagy

Science.gov (United States)

Cortes, Constanza J.; Qin, Kefeng; Norstrom, Eric M.; Green, William N.; Bindokas, Vytautas P.; Mastrianni, James A.

2013-01-01

Prion diseases are linked to the accumulation of a misfolded isoform (PrPSc) of prion protein (PrP). Evidence suggests that lysosomes are degradation endpoints and sites of the accumulation of PrPSc. We questioned whether lysosomes participate in the early quality control of newly generated misfolded PrP. We found PrP carrying the disease-associated T182A mutation (Mut-PrP) was delivered to lysosomes in a Golgi-independent manner. Time-lapse live cell imaging revealed early formation and uptake of GFP-tagged Mut-PrP aggregates into LysoTracker labeled vesicles. Compared with Wt-PrP, Mut-PrP expression was associated with an elevation in several markers of the autophagy-lysosomal pathway, and it extensively colocalized with the autophagosome-specific marker, LC3B. In autophagy deficient (ATG5−/−) mouse embryonic fibroblasts, or in normal cells treated with the autophagy-inhibitor 3-MA, Mut-PrP colocalization with lysosomes was reduced to a similar extent. Additionally, 3-MA selectively impaired the degradation of insoluble Mut-PrP, resulting in an increase in protease-resistant PrP, whereas the induction of autophagy by rapamycin reduced it. These findings suggest that autophagy might function as a quality control mechanism to limit the accumulation of misfolded PrP that normally leads to the generation of PrPSc. PMID:24454378

On the subgroups of PR groups

International Nuclear Information System (INIS)

Lebedenko, V.M.

1979-01-01

The subgroups of PR-groups are being studied, i.e., the subgroups of connected and simply connected nonabelian Lie groups, their Lie algebras being defined by the commuting relations of the type [Hsub(i), Hsub(j)] = rsub(ij)Hsub(i) (i 1 of PR-group G there exists such complementary subgroup G 2 and that group G is expanded in semidirect product G = G 1 xG 2 [ru

Features of the advertising and PR in tourism

OpenAIRE

M. A. Zubarieva

2015-01-01

The article discusses the use of topical issues of important tools of social communication of applied tactical direction (advertising) and strategic (PR). The main types of advertising in tourism and types of PR ­ activities are characterized.The main difference between advertising and PR in the tourism sector is defined, the main attention is given to correct choice of optimal (most efficient) advertising channel (means). Specific nature, advertising issues as the main tool for the promotion...

On orbits and admissible subalgebras for the PR groups

International Nuclear Information System (INIS)

Lebedenko, V.M.

1977-01-01

The PR-groups (Lie groups with commutation relations of [Hsub(i),Hsub(0)] = rsub(ij)Hsub(i) (i< j)-type) are investigated within the Kirillov orbit method. Orbits for all the PR-groups are constructed in a general form. For some classes of PR-groups orbits and admissible subalgebras are obtained in an explicit form

Pressure dependence of crystal field splitting in Pr pnictides and chalcogenides

International Nuclear Information System (INIS)

Schirber, J.E.; Weaver, H.T.; Ginley, D.S.

1978-01-01

We have measured the pressure dependence of the Pr nuclear magnetic resonance shift in PrN, PrP, PrSb, PrAs, PrS and PrSe. The shifts in all the pnictides increase while in the chalcogenides the shifts decrease with pressure. The rare earth frequency shift is inversely proportional to the crystal field splitting in the context of the point charge model (PCM) so a decrease would be expected for all of these materials at a rate of 5/3 the volume compressibility. Our values for the pnictides tend to be considerably larger than the PCM value as well as the wrong sign. The chalcogenide values are much nearer in magnitude and are of the right sign for the PCM. Contrary to the report of Guertin et al. we see no anomaly in the pressure dependence of the susceptibility of PrS. The fact that PrN which is reported to be non-metallic also shows the wrong sign for the PCM presents difficulties for various conduction electron explanations for this unexpected behavior of the pnictides

Nomes próprios em Paulo Leminski

Directory of Open Access Journals (Sweden)

Olga Kempinska

2011-06-01

Full Text Available Este artigo propõe uma discussão sobre o uso dos nomes próprios na obra de Paulo Leminski. Com especial atenção debruça- se sobre a relação entre o nome próprio e o processo social de identificação e de classificação e sobre o potencial subversivo do humor associado ao uso poético do nome próprio por Leminski. Em conclusão insiste-se na ambiguidade envolvida na recepção do humor, subversivo e, ao mesmo tempo, comprometido devido a seu apelo à empatia do leitor.

Fracasos en prótesis parcial removible

OpenAIRE

Samsó Manzanedo, Jorge; Salsench Cabré, Juan

1986-01-01

Escribir sobre fracasos en prótesis parcial removible entraña ciertas dificultades, entre ellas el especificar qué es un fracaso, qué es un error y lo más difícil, qué es el éxito. Los que esto escriben han visto prótesis parciales removibles ver­daderamente mal realizadas, que han causado un gran daño en el sis­tema estomatognático del portador sin que él se diera cuenta y lo que aún es peor, creyendo que su prótesis satisfacía plenamente los requeri­mientos para poderla considerar un éxito....

An insight to the molecular interactions of the FDA approved HIV PR drugs against L38L↑N↑L PR mutant.

Science.gov (United States)

Sanusi, Zainab K; Govender, Thavendran; Maguire, Glenn E M; Maseko, Sibusiso B; Lin, Johnson; Kruger, Hendrik G; Honarparvar, Bahareh

2018-03-01

The aspartate protease of the human immune deficiency type-1 virus (HIV-1) has become a crucial antiviral target in which many useful antiretroviral inhibitors have been developed. However, it seems the emergence of new HIV-1 PR mutations enhances drug resistance, hence, the available FDA approved drugs show less activity towards the protease. A mutation and insertion designated L38L↑N↑L PR was recently reported from subtype of C-SA HIV-1. An integrated two-layered ONIOM (QM:MM) method was employed in this study to examine the binding affinities of the nine HIV PR inhibitors against this mutant. The computed binding free energies as well as experimental data revealed a reduced inhibitory activity towards the L38L↑N↑L PR in comparison with subtype C-SA HIV-1 PR. This observation suggests that the insertion and mutations significantly affect the binding affinities or characteristics of the HIV PIs and/or parent PR. The same trend for the computational binding free energies was observed for eight of the nine inhibitors with respect to the experimental binding free energies. The outcome of this study shows that ONIOM method can be used as a reliable computational approach to rationalize lead compounds against specific targets. The nature of the intermolecular interactions in terms of the host-guest hydrogen bond interactions is discussed using the atoms in molecules (AIM) analysis. Natural bond orbital analysis was also used to determine the extent of charge transfer between the QM region of the L38L↑N↑L PR enzyme and FDA approved drugs. AIM analysis showed that the interaction between the QM region of the L38L↑N↑L PR and FDA approved drugs are electrostatic dominant, the bond stability computed from the NBO analysis supports the results from the AIM application. Future studies will focus on the improvement of the computational model by considering explicit water molecules in the active pocket. We believe that this approach has the potential to

An insight to the molecular interactions of the FDA approved HIV PR drugs against L38L↑N↑L PR mutant

Science.gov (United States)

Sanusi, Zainab K.; Govender, Thavendran; Maguire, Glenn E. M.; Maseko, Sibusiso B.; Lin, Johnson; Kruger, Hendrik G.; Honarparvar, Bahareh

2018-03-01

The aspartate protease of the human immune deficiency type-1 virus (HIV-1) has become a crucial antiviral target in which many useful antiretroviral inhibitors have been developed. However, it seems the emergence of new HIV-1 PR mutations enhances drug resistance, hence, the available FDA approved drugs show less activity towards the protease. A mutation and insertion designated L38L↑N↑L PR was recently reported from subtype of C-SA HIV-1. An integrated two-layered ONIOM (QM:MM) method was employed in this study to examine the binding affinities of the nine HIV PR inhibitors against this mutant. The computed binding free energies as well as experimental data revealed a reduced inhibitory activity towards the L38L↑N↑L PR in comparison with subtype C-SA HIV-1 PR. This observation suggests that the insertion and mutations significantly affect the binding affinities or characteristics of the HIV PIs and/or parent PR. The same trend for the computational binding free energies was observed for eight of the nine inhibitors with respect to the experimental binding free energies. The outcome of this study shows that ONIOM method can be used as a reliable computational approach to rationalize lead compounds against specific targets. The nature of the intermolecular interactions in terms of the host-guest hydrogen bond interactions is discussed using the atoms in molecules (AIM) analysis. Natural bond orbital analysis was also used to determine the extent of charge transfer between the QM region of the L38L↑N↑L PR enzyme and FDA approved drugs. AIM analysis showed that the interaction between the QM region of the L38L↑N↑L PR and FDA approved drugs are electrostatic dominant, the bond stability computed from the NBO analysis supports the results from the AIM application. Future studies will focus on the improvement of the computational model by considering explicit water molecules in the active pocket. We believe that this approach has the potential to provide

Dos prólogos para un mismo informe: El Nunca Más y la memoria de las desapariciones

Directory of Open Access Journals (Sweden)

Emilio Crenzel

2007-12-01

Full Text Available En este artículo se analizarán dos prólogos al informe Nunca Más, elaborado por la Comisión Nacional sobre la Desaparición de Personas en 1984. El primero, escrito por la Comisión, expuso la interpretación del gobierno de Alfonsín sobre el pasado de violencia política y horror y postuló una nueva lectura sobre la identidad de los desaparecidos y el papel de la sociedad argentina en esos hechos. El segundo, elaborado por la Secretaría de Derechos Humanos de la Nación fue añadido en 2006. Su comparación ilustrará los cambios y continuidades en la memoria del pasado reciente en el país.In this article I analyze two prologues to the report Never Again, elaborated by the National Commission on the Disappearance in 1984. The first written by the commission, exposed the interpretation of the government of Alfonsín about the past of political violence and horror, postulated a new perspective about the identity of the missing persons and the role of the Argentine society in these facts. The second one elaborated by the Secretariat of Human rights of the Nation was added in 2006. The comparison will illustrate the changes and continuities in the memory of the recent past in the country.

Tratamiento del concepto de ser vivo y los reinos monera, protista y fungi en la atención a la diversidad de 1º ESO

OpenAIRE

Nepote Gorriz, Ainara

2012-01-01

Los contenidos que se tratan en este proyecto intentando diseñar unos contenidos y actividades conceptualmente transparentes para el alumnado, se dividen en 2 grandes apartados: primero se trata el concepto de ser vivo con 3 actividades diferentes, y luego los reinos monera, protista y fungi. Los objetivos generales que se establecen para este proyecto son los siguientes: 1. Acercar el concepto de ser vivo a alumnos y a alumnas de atención de la diversidad de 1º ESO ampliand...

33 CFR 161.20 - Position Report (PR).

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Position Report (PR). 161.20 Section 161.20 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED... Report (PR). A vessel must report its name and position: (a) Upon point of entry into a VMRS area; (b) At...

Plant Reliability - an Integrated System for Management (PR-ISM)

International Nuclear Information System (INIS)

Aukeman, M.C.; Leininger, E.G.; Carr, P.

1984-01-01

The Toledo Edison Company, located in Toledo, Ohio, United States of America, recently implemented a comprehensive maintenance management information system for the Davis-Besse Nuclear Power Station. The system is called PR-ISM, meaning Plant Reliability - An Integrated System for Management. PR-ISM provides the tools needed by station management to effectively plan and control maintenance and other plant activities. The PR-ISM system as it exists today consists of four integrated computer applications: equipment data base maintenance, maintenance work order control, administrative activity tracking, and technical specification compliance. PR-ISM is designed as an integrated on-line system and incorporates strong human factors features. PR-ISM provides each responsible person information to do his job on a daily basis and to look ahead towards future events. It goes beyond 'after the fact' reporting. In this respect, PR-ISM is an 'interactive' control system which: captures work requirements and commitments as they are identified, provides accurate and up-to-date status immediately to those who need it, simplifies paperwork and reduces the associated time delays, provides the information base for work management and reliability analysis, and improves productivity by replacing clerical tasks and consolidating maintenance activities. The functional and technical features of PR-ISM, the experience of Toledo Edison during the first year of operation, and the factors which led to the success of the development project are highlighted. (author)

Milky Way Past Was More Turbulent Than Previously Known

Science.gov (United States)

2004-04-01

astronomers who study the birth and evolution of the Milky Way and other galaxies. Now the rich results of a 15 year-long marathon survey by a Danish-Swiss-Swedish research team [2] are providing some of the answers. 1,001 nights at the telescopes ESO PR Photo 10a/04 ESO PR Photo 10a/04 Sky distribution of the observed stars [Preview - JPEG: 518 x 400 pix - 96k] [Normal - JPEG: 1035 x 800 pix - 897k] Caption: ESO PR Photo 10a/04 shows the distribution on the sky of the approx. 14,000 observed stars. The region on the left that is denser than its surroundings is the nearby Hyades star cluster. The team spent more than 1,000 observing nights over 15 years at the Danish 1.5-m telescope of the European Southern Observatory at La Silla (Chile) and at the Swiss 1-m telescope of the Observatoire de Haute-Provence (France). Additional observations were made at the Harvard-Smithsonian Center for Astrophysics in the USA. A total of more than 14,000 solar-like stars (so-called F- and G-type stars) were observed at an average of four times each - a total of no less than 63,000 individual spectroscopic observations! This now complete census of neighbourhood stars provides distances, ages, chemical analysis, space velocities and orbits in the general rotation of the Milky Way. It also identifies those stars (about 1/3 of them all) which the astronomers found to be double or multiple. This very complete data set for the stars in the solar neighbourhood will provide food for thought by astronomers for years to come. A dream come true ESO PR Photo 10b/04 ESO PR Photo 10b/04 Stars in the solar neighbourhood [Preview - JPEG: 459 x 400 pix - 29k] [Normal - JPEG: 918 x 800 pix - 441k] [FullRes - JPEG: 3000 x 2613 pix - 4.4Mb] Caption: ESO PR Photo 10b/04 provides an artist's view of the observed group of stars orbiting the Milky Way together with the Sun, as seen by an imaginary observer outside the Galaxy. The orbit of the Sun is shown. For clarity, the stars surrounding the local volume have

PrP0\\0 mice show behavioral abnormalities that suggest PrPC has a role in maintaining the cytoskeleton.

Science.gov (United States)

Background/Introduction. PrPC is highly conserved among mammals, but its natural function is unclear. Prnp ablated mice (PrP0/0) appear to develop normally and are able to reproduce. These observations seem to indicate that the gene is not essential for viability, in spite of it being highly conse...

Recomendaciones para aumentar la participación ciudadana en ...

International Development Research Centre (IDRC) Digital Library (Canada)

Hubert Linders

IDRC apoya la investigación en los países en desarrollo para promover el crecimiento y el desarrollo. Trabaja con investigadores e innovadores en esos países para encontrar soluciones prácticas y a largo plazo a los problemas sociales, económicos y ambientales que enfrentan sus sociedades. Su objetivo es llevar el ...

PrEP implementation in the Asia-Pacific region: opportunities, implementation and barriers

Science.gov (United States)

Zablotska, Iryna; Grulich, Andrew E; Phanuphak, Nittaya; Anand, Tarandeep; Janyam, Surang; Poonkasetwattana, Midnight; Baggaley, Rachel; van Griensven, Frits; Lo, Ying-Ru

2016-01-01

Introduction HIV epidemics in the Asia-Pacific region are concentrated among men who have sex with men (MSM) and other key populations. Pre-exposure prophylaxis (PrEP) is an effective HIV prevention intervention and could be a potential game changer in the region. We discuss the progress towards PrEP implementation in the Asia-Pacific region, including opportunities and barriers. Discussion Awareness about PrEP in the Asia-Pacific is still low and so are its levels of use. A high proportion of MSM who are aware of PrEP are willing to use it. Key PrEP implementation barriers include poor knowledge about PrEP, limited access to PrEP, weak or non-existent HIV prevention programmes for MSM and other key populations, high cost of PrEP, stigma and discrimination against key populations and restrictive laws in some countries. Only several clinical trials, demonstration projects and a few larger-scale implementation studies have been implemented so far in Thailand and Australia. However, novel approaches to PrEP implementation have emerged: researcher-, facility- and community-led models of care, with PrEP services for fee and for free. The WHO consolidated guidelines on HIV testing, treatment and prevention call for an expanded access to PrEP worldwide and have provided guidance on PrEP implementation in the region. Some countries like Australia have released national PrEP guidelines. There are growing community leadership and consultation processes to initiate PrEP implementation in Asia and the Pacific. Conclusions Countries of the Asia-Pacific region will benefit from adding PrEP to their HIV prevention packages, but for many this is a critical step that requires resourcing. Having an impact on the HIV epidemic requires investment. The next years should see the region transitioning from limited PrEP implementation projects to growing access to PrEP and expansion of HIV prevention programmes. PMID:27760688

Cytosolically expressed PrP GPI-signal peptide interacts with mitochondria.

Science.gov (United States)

Guizzunti, Gianni; Zurzolo, Chiara

2015-01-01

We previously reported that PrP GPI-anchor signal peptide (GPI-SP) is specifically degraded by the proteasome. Additionally, we showed that the point mutation P238S, responsible for a genetic form of prion diseases, while not affecting the GPI-anchoring process, results in the accumulation of PrP GPI-SP, suggesting the possibility that PrP GPI-anchor signal peptide could play a role in neurodegenerative prion diseases. We now show that PrP GPI-SP, when expressed as a cytosolic peptide, is able to localize to the mitochondria and to induce mitochondrial fragmentation and vacuolarization, followed by loss in mitochondrial membrane potential, ultimately resulting in apoptosis. Our results identify the GPI-SP of PrP as a novel candidate responsible for the impairment in mitochondrial function involved in the synaptic pathology observed in prion diseases, establishing a link between PrP GPI-SP accumulation and neuronal death.

Study into non-quasibinary sections of Pr2S3-Bi2S3-Pr2O3 triple system (Bi2S3)0. 45(Pr2O3)0. 55 - (Bi2S3)0. 45(Pr2S3)0. 55 and (Bi2S3)0. 75 (Pr2S3)0. 25 - (Bi2S3)0. 75(Pr2O3)0. 25

OpenAIRE

НЕЙМАТОВА А.В.; МАМЕДОВ Ф.М.; БАХТИЯРЛЫ И.Б.

2016-01-01

Методами дифференциальнo-термическoго (ДТ), рентгенофазового (РФ), микроструктурного (МС) методов анализа исследованы неквазибинарные разрезы (Bi2S3)0.45(Pr2O3)0.55 (Bi2S3)0.45(Pr2S3)0.55 и (Bi2S3)0.75 (Pr2S3)0.25 (Bi2S3)0.75(Pr2O3)0.25 тройной системы Pr2S3-Bi2S3-Pr2O3 построена диаграмма состояния, определены координанты нони моновариантныхравновесий....

Young Stars in Old Galaxies - a Cosmic Hide and Seek Game

Science.gov (United States)

2002-05-01

Surprise Discovery with World's Leading Telescopes [1] Summary Combining data from the NASA/ESA Hubble Space Telescope (HST) and the ESO Very Large Telescope (VLT) , a group of European and American astronomers [2] have made an unexpected, major discovery. They have identified a huge number of "young" stellar clusters , only a few billion years old [3], inside an "old" elliptical galaxy (NGC 4365), probably aged some 12 billion years. For the first time, it has been possible to identify several distinct periods of star-formation in a galaxy as old as this one . Elliptical galaxies like NGC 4365 have until now been considered to have undergone one early star-forming period and thereafter to be devoid of any star formation. However, the combination of the best and largest telescopes in space and on the ground has now clearly shown that there is more than meets the eye. This important new information will help to understand the early history of galaxies and the general theory of star formation in the Universe . PR Photo 15a/02 : Combined HST+VLT image of elliptical galaxy NGC 4365 PR Photo 15b/02 : Same image, with "old" and "young" stellar clusters indicated PR Photo 15c/02 : Animated GIF image, showing the three cluster populations observed in NGC 4365 Do elliptical galaxies only contain old stars? One of the challenges of modern astronomy is to understand how galaxies, those large systems of stars, gas and dust, form and evolve. In this connection, a central question has always been to learn when most of the stars in the Universe formed. Did this happen at a very early stage, within a few billion years after the Big Bang? Or were a significant number of the stars we now observe formed much more recently? Spectacular collisions between galaxies take place all the time, triggering the formation of thousands or even millions of stars, cf. ESO PR Photo 29b/99 of the dramatic encounter between NGC 6872 and IC 4970. However, when looking at the Universe as a whole, most

Application of the GIF PR and PP methodology to a commercial fast reactor system for a preliminary analysis of PR scenarios

International Nuclear Information System (INIS)

Rossi, Fabiana

2015-01-01

The Generation IV International Forum (GIF) Proliferation Resistance and Physical Protection (PR and PP) Working Group has developed a methodology for the PR and PP evaluation of the next generation Nuclear Energy Systems (NESs). Following the methodology proposed by the working group, applicable to assessing the proliferation resistance of an NES and its individual elements, the main objective of this work is to apply the methodology to show an example of how its results could be used by designers to improve the PR of the system. In this study, the reactor site of a hypothetical and commercial sodium‑cooled fast neutron nuclear reactor system (SFR) was used as the target NES for the application of the methodology. The design of this SFR is based on the layout of the Japanese Sodium Fast Reactor (JSFR) with a safeguards design based on the safeguards approach of the Japanese prototype fast breeder reactor Monju. The methodology is applied to all the PR scenarios described in the methodology: diversion, misuse and breakout. The methodology was first applied to the SFR to check if this system meets the target of PR as described in the GIF goal; secondly, a comparison between the SFR and a light water reactor (LWR) with an open fuel cycle was performed to evaluate if and how it would be possible to improve the PR and PP of the SFR. The LWR layout is based on the European Pressurized Water Reactor. The comparison was implemented according to the following example development target: achieving proliferation resistance to material diversion similar or superior to domestic and international advanced LWR. Three main actions were performed: implement the evaluation methodology based on its assumptions; characterize the PR and PP for the nuclear energy system applying the methodology to the SFR; and identify recommendations for system designers through comparing the SFR with the LWR.

RIZ Tumor and Breast Cancer: The PR Domain

National Research Council Canada - National Science Library

Aznar-Derunes, Celine

2005-01-01

.... RIZ is the founding member of the PR-domain family of zinc finger genes. Two protein products are produced from the RIZ gene which differ by the presence or the absence of the PR domain: RIZ1 and RIZ2...

Phase equilibria of the Al-Pr-Zr ternary system at 773 K

International Nuclear Information System (INIS)

She, Jia; Zhan, Yongzhong; Li, Chunliu; Du, Yong; Xu, Honghui; He, Yuehui

2010-01-01

The phase equilibria of the Al-Pr-Zr ternary system at 773 K have been investigated mainly by means of X-ray powder diffraction (XRD), scanning electron microscopy (SEM) and differential thermal analysis (DTA). The 14 binary compounds, i.e. AlZr 3 , AlZr 2 , Al 2 Zr 3 , Al 3 Zr 4 , AlZr, Al 3 Zr 2 , Al 2 Zr, Al 3 Zr, α-Al 11 Pr 3 , Al 3 Pr, Al 2 Pr, β-AlPr, AlPr 2 and β-AlPr 3 were confirmed. No binary compound was found in the Pr-Zr binary system. The result shows that the isothermal section of the Al-Pr-Zr ternary system at 773 K consists of 17 single-phase regions, 31 two-phase regions and 15 three-phase regions. All the intermediate compounds phases in this system have not a remarkable solid solution at 773 K. No ternary compound is found in this work.

Milky Way's super-efficient particle accelerators caught in the act

Science.gov (United States)

2009-06-01

Thanks to a unique "ballistic study" that combines data from ESO's Very Large Telescope and NASA's Chandra X-ray Observatory, astronomers have now solved a long-standing mystery of the Milky Way's particle accelerators. They show in a paper published today on Science Express that cosmic rays from our galaxy are very efficiently accelerated in the remnants of exploded stars. ESO PR Photo 23a/09 The rim of RCW 86 ESO PR Photo 23b/09 DSS + insert, annotated ESO PR Photo 23c/09 DSS image ESO PR Video 23a/09 Zoom-in RCW 86 During the Apollo flights astronauts reported seeing odd flashes of light, visible even with their eyes closed. We have since learnt that the cause was cosmic rays -- extremely energetic particles from outside the Solar System arriving at the Earth, and constantly bombarding its atmosphere. Once they reach Earth, they still have sufficient energy to cause glitches in electronic components. Galactic cosmic rays come from sources inside our home galaxy, the Milky Way, and consist mostly of protons moving at close to the speed of light, the "ultimate speed limit" in the Universe. These protons have been accelerated to energies exceeding by far the energies that even CERN's Large Hadron Collider will be able to achieve. "It has long been thought that the super-accelerators that produce these cosmic rays in the Milky Way are the expanding envelopes created by exploded stars, but our observations reveal the smoking gun that proves it", says Eveline Helder from the Astronomical Institute Utrecht of Utrecht University in the Netherlands, the first author of the new study. "You could even say that we have now confirmed the calibre of the gun used to accelerate cosmic rays to their tremendous energies", adds collaborator Jacco Vink, also from the Astronomical Institute Utrecht. For the first time Helder, Vink and colleagues have come up with a measurement that solves the long-standing astronomical quandary of whether or not stellar explosions produce enough

The thermodynamic characteristics of vaporization in the NaI-PrI3 system

Science.gov (United States)

Motalov, V. B.; Kudin, L. S.; Markus, T.

2009-05-01

The vaporization of the NaI-PrI3 quasi-binary system was studied by high-temperature mass spectrometry over the whole concentration range. At 623-994 K, saturated vapor contained not only (NaI) n and (PrI3) n molecules ( n = 1, 2) and Na+(NaI) n ( n = 0-4) and I-(PrI3) n ( n = 1-2) ions but also mixed molecular and ionic associates recorded for the first time (NaPrI4, Na2PrI5, NaPrI{3/+}, Na2PrI{4/+}, Na3PrI{5/+}, Na4PrI{6/+}, NaPrI{5/-}, and NaPr2I{8/-}). The partial vapor pressures of molecules were calculated, and the equilibrium constants of the dissociation of neutral and charged associates were measured. The enthalpies of molecular and ion-molecular reactions were determined, and the enthalpies of formation of gaseous molecules and ions were obtained.

A "Genetic Study" of the Galaxy

Science.gov (United States)

2006-09-01

Looking in detail at the composition of stars with ESO's VLT, astronomers are providing a fresh look at the history of our home galaxy, the Milky Way. They reveal that the central part of our Galaxy formed not only very quickly but also independently of the rest. "For the first time, we have clearly established a 'genetic difference' between stars in the disc and the bulge of our Galaxy," said Manuela Zoccali, lead author of the paper presenting the results in the journal Astronomy and Astrophysics [1]. "We infer from this that the bulge must have formed more rapidly than the disc, probably in less than a billion years and when the Universe was still very young." ESO PR Photo 34a/06 ESO PR Photo 34a/06 The Field around Baade's Window The Milky Way is a spiral galaxy, having pinwheel-shaped arms of gas, dust, and stars lying in a flattened disc, and extending directly out from a spherical nucleus of stars in the central region. The spherical nucleus is called a bulge, because it bulges out from the disc. While the disc of our Galaxy is made up of stars of all ages, the bulge contains old stars dating from the time the galaxy formed, more than 10 billion years ago. Thus, studying the bulge allows astronomers to know more about how our Galaxy formed. To do this, an international team of astronomers [2] analysed in detail the chemical composition of 50 giant stars in four different areas of the sky towards the Galactic bulge. They made use of the FLAMES/UVES spectrograph on ESO's Very Large Telescope to obtain high-resolution spectra. The chemical composition of stars carries the signature of the enrichment processes undergone by the interstellar matter up to the moment of their formation. It depends on the previous history of star formation and can thus be used to infer whether there is a 'genetic link' between different stellar groups. In particular, comparison between the abundance of oxygen and iron in stars is very illustrative. Oxygen is predominantly produced in

Quantitating PrP Polymorphisms Present in Prions from Heterozygous Scrapie-Infected Sheep.

Science.gov (United States)

Silva, Christopher J; Erickson-Beltran, Melissa L; Hui, Colleen; Badiola, Juan José; Nicholson, Eric M; Requena, Jesús R; Bolea, Rosa

2017-01-03

Scrapie is a prion (PrP Sc ) disease of sheep. The incubation period of sheep scrapie is strongly influenced by polymorphisms at positions 136, 154, and 171 of a sheep's normal cellular prion protein (PrP C ). Chymotrypsin was used to digest sheep recombinant PrP to identify a set of characteristic peptides [M 132 LGSXMSRPL 141 (X = A or V), Y 153 XENMY 158 (X,= H or R), and Y 166 RPVDXY 172 (X = H, K, Q, or R)] that could be used to detect and quantitate polymorphisms at positions 136, 154, and 171 of sheep PrP C or PrP Sc . These peptides were used to develop a multiple reaction monitoring method (MRM) to detect the amounts of a particular polymorphism in a sample of PrP Sc isolated from sheep heterozygous for their PrP C proteins. The limit of detection for these peptides was less than 50 attomole. Spinal cord tissue from heterozygous (ARQ/VRQ or ARH/ARQ) scrapie-infected Rasa Aragonesa sheep was analyzed using this MRM method. Both sets of heterozygotes show the presence of both polymorphisms in PrP Sc . This was true for samples containing both proteinase K (PK)-sensitive and PK-resistant PrP Sc and samples containing only the PK-resistant PrP Sc . These results show that heterozygous animals contain PrP Sc that is composed of significant amounts of both PrP polymorphisms.

Solar Games at Paranal

Science.gov (United States)

2008-05-01

Cerro Paranal, home of ESO's Very Large Telescope, is certainly one of the best astronomical sites on the planet. Stunning images, obtained by ESO staff at Paranal, of the green and blue flashes, as well as of the so-called 'Gegenschein', are real cases in point. Green Flash at Paranal ESO PR Photo 12a/08 Green Flash at Paranal The Earth's atmosphere is a gigantic prism that disperses sunlight. In the most ideal atmospheric conditions, such as those found regularly above Cerro Paranal, this will lead to the appearance of so-called green and blue flashes at sunset. The phenomenon is so popular on the site that it is now the tradition for the Paranal staff to gather daily on the telescope platform to observe the sunset and its possible green flash before starting their long night of observations. The green and blue flashes are fleeting events that require an unobstructed view of the setting Sun, and a very stable atmosphere. These conditions are very often met at Paranal, a 2635m high mountain in the Chilean Atacama Desert, where the sky is cloudless more than 300 days a year. Paranal is home of ESO's Very Large Telescope, an ensemble of four 8.2-m telescopes and four 1.8-m Auxiliary Telescopes that together form the world's most advanced optical telescope. Blue Flash at Paranal ESO PR Photo 12b/08 Blue Flash at Paranal ESO staff Stéphane Guisard has been chasing green flashes for many years and has been able to capture them on many occasions. The picture shown above is one of many examples from his collection. "The most challenging is to capture the green flash while still seeing the rest of the Sun with all its colours," says Guisard. His colleague Guillaume Blanchard was even luckier. On Christmas Eve, as he was one of the few to follow the tradition of looking at the sunset, he had the chance to immortalise a blue flash using his hobby telescope. ESO astronomer Yuri Beletsky also likes to take photographs from Paranal, but he prefers the night views. This allows

A phase III randomized controlled study on the efficacy and improved bowel function of prolonged-release (PR) oxycodone-naloxone (up to 160/80 mg daily) vs oxycodone PR.

Science.gov (United States)

Dupoiron, D; Stachowiak, A; Loewenstein, O; Ellery, A; Kremers, W; Bosse, B; Hopp, M

2017-10-01

Oxycodone/naloxone (OXN PR) is a prolonged-release formulation containing oxycodone and naloxone in a 2:1 ratio. This study aimed to evaluate the tolerability and efficacy of doses up to OXN160/80 mg PR compared with oxycodone prolonged-release formulation (OxyPR) in a randomised controlled trial. Two hundred and forty-three patients were randomised to treatment with OXN PR (n = 123) or OxyPR (n = 120) during the 5-week double-blind study. Measured were: opioid-induced constipation [bowel function index score (BFI)]; analgesic efficacy (NRS 0-10); daily laxative rescue medication use; rescue medication use, and the number of complete spontaneous bowel movements (CSBMs) per week. A subanalysis was conducted in cancer patients. Greater reductions in mean BFI scores were reported for the OXN PR group compared with OxyPR from Week 1 onwards; at Week 5 the mean change from baseline was -32.5 versus -14.2. Average 24-h pain scores were low and remained stable in the range 3-4 in both treatment groups. Analgesic rescue medication use was similar between the groups. Patients receiving OXN PR used significantly lower mean daily doses of laxative rescue medication than those receiving OxyPR (P = 0.006). The number of CSBM in the OXN PR group approximately doubled compared with a 25% decrease in the OxyPR group. Comparable results to the total study population were reported in the cancer patient subgroup. OXN PR in daily doses of up to 160/80 mg significantly improves bowel function compared with equivalent doses of OxyPR while still providing comparable analgesic efficacy. Effective analgesia can be achieved using oxycodone/naloxone PR up to 160/80 mg daily without compromising bowel function. A similar outcome was reported in cancer and non-cancer patients. © 2017 The Authors. European Journal of Pain published by John Wiley & Sons Ltd on behalf of European Pain Federation - EFIC®.

Deletion of Pr130 Interrupts Cardiac Development in Zebrafish

Directory of Open Access Journals (Sweden)

Jie Yang

2016-11-01

Full Text Available Protein phosphatase 2 regulatory subunit B, alpha (PPP2R3A, a regulatory subunit of protein phosphatase 2A (PP2A, is a major serine/threonine phosphatase that regulates crucial function in development and growth. Previous research has implied that PPP2R3A was involved in heart failure, and PR130, the largest transcription of PPP2R3A, functioning in the calcium release of sarcoplasmic reticulum (SR, plays an important role in the excitation-contraction (EC coupling. To obtain a better understanding of PR130 functions in myocardium and cardiac development, two pr130-deletion zebrafish lines were generated using clustered regularly interspaced short palindromic repeats (CRISPR/CRISPR-associated proteins (Cas system. Pr130-knockout zebrafish exhibited cardiac looping defects and decreased cardiac function (decreased fractional area and fractional shortening. Hematoxylin and eosin (H&E staining demonstrated reduced cardiomyocytes. Subsequent transmission electron microscopy revealed that the bright and dark bands were narrowed and blurred, the Z- and M-lines were fogged, and the gaps between longitudinal myocardial fibers were increased. Additionally, increased apoptosis was observed in cardiomyocyte in pr130-knockout zebrafish compared to wild-type (WT. Taken together, our results suggest that pr130 is required for normal myocardium formation and efficient cardiac contractile function.

Las prácticas en el contexto comunicativo

Directory of Open Access Journals (Sweden)

Guillermo Orozco Gómez

2015-01-01

Full Text Available La comunicación debe ser entendida como proceso y producto de diversas prácticas sociales, cuyos componentes básicos son la sociabilidad, la ritualidad y la tecnicidad. Desde una perspectiva democrática, esas prácticas deben ser fortalecidas, especialmente en uno de sus aspectos esenciales: el diálogo y los "escenarios para ese diálogo". Actualmente el desafío radica en el fortalecimiento de las prácticas sociales -autónomas y democráticas- y especialmente de la comunicación, producto y componente de ellas.

Phase equilibria of the Al-Pr-Zr ternary system at 773 K

Energy Technology Data Exchange (ETDEWEB)

She, Jia [Laboratory of Nonferrous Metal Materials and New Processing Technology, Ministry of Education, Guangxi University, Nanning, Guangxi 530004 (China); Zhan, Yongzhong, E-mail: zyzmatres@yahoo.com.c [Laboratory of Nonferrous Metal Materials and New Processing Technology, Ministry of Education, Guangxi University, Nanning, Guangxi 530004 (China); Li, Chunliu [Laboratory of Nonferrous Metal Materials and New Processing Technology, Ministry of Education, Guangxi University, Nanning, Guangxi 530004 (China); Du, Yong; Xu, Honghui; He, Yuehui [State Key Laboratory of Powder Metallurgy, Central South University, Changsha, Hunan 410083 (China)

2010-07-30

The phase equilibria of the Al-Pr-Zr ternary system at 773 K have been investigated mainly by means of X-ray powder diffraction (XRD), scanning electron microscopy (SEM) and differential thermal analysis (DTA). The 14 binary compounds, i.e. AlZr{sub 3}, AlZr{sub 2}, Al{sub 2}Zr{sub 3}, Al{sub 3}Zr{sub 4}, AlZr, Al{sub 3}Zr{sub 2}, Al{sub 2}Zr, Al{sub 3}Zr, {alpha}-Al{sub 11}Pr{sub 3}, Al{sub 3}Pr, Al{sub 2}Pr, {beta}-AlPr, AlPr{sub 2} and {beta}-AlPr{sub 3} were confirmed. No binary compound was found in the Pr-Zr binary system. The result shows that the isothermal section of the Al-Pr-Zr ternary system at 773 K consists of 17 single-phase regions, 31 two-phase regions and 15 three-phase regions. All the intermediate compounds phases in this system have not a remarkable solid solution at 773 K. No ternary compound is found in this work.

Pr2Fe14B/α-Fe nanocomposites for thermal applications

International Nuclear Information System (INIS)

Silva, Suelanny Carvalho da

2012-01-01