WorldWideScience

Sample records for hya eso pr

  1. ESO PR Highlights in 2007

    Science.gov (United States)

    2008-01-01

    Another great year went by for ESO, the European Organisation for Astronomical Research in the Southern Hemisphere. From 1 January 2007, with the official joining of the Czech Republic, ESO has 13 member states, and since September, ESO has a new Director General, Tim de Zeeuw (ESO 03/07 and 38/07). Many scientific discoveries were made possible with ESO's telescopes. Arguably, the most important is the discovery of the first Earth-like planet in the habitable zone of a low-mass red dwarf (ESO 22/07). If there is water on this planet, then it should be liquid! ESO PR Highlights 2007 This is a clickable map. These are only some of the press releases issued by ESO in 2007. For a full listing, please go to ESO 2007 page. In our own Solar System also, astronomers made stunning breakthroughs with ESO's telescopes, observing the effect of the light from the Sun on an asteroid's rotation (ESO 11/07), describing in unprecedented detail the double asteroid Antiope (ESO 18/07), peering at the rings of Uranus (ESO 37/07), discovering a warm south pole on Neptune (ESO 41/07), showing a widespread and persistent morning drizzle of methane over the western foothills of Titan's major continent (ESO 47/07), and studying in the greatest details the wonderful Comet McNaught (ESO 05/07 and 07/07). In the study of objects slightly more massive than planets, the VLT found that brown dwarfs form in a similar manner to normal stars (ESO 24/07). The VLT made it also possible to measure the age of a fossil star that was clearly born at the dawn of time (ESO 23/07). Other discoveries included reconstructing the site of a flare on a solar-like star (ESO 53/07), catching a star smoking (ESO 34/07), revealing a reservoir of dust around an elderly star (ESO 43/07), uncovering a flat, nearly edge-on disc of silicates in the heart of the magnificent Ant Nebula (ESO 42/07), finding material around a star before it exploded (ESO 31/07), fingerprinting the Milky Way (ESO 15/07), revealing a rich

  2. ESO PR Highlights in 2005

    Science.gov (United States)

    2006-01-01

    2005 was the year of Physics. It was thus also in part the year of astronomy and this is clearly illustrated by the numerous breakthroughs that were achieved, in particular using ESO's telescopes. One of the highlights was without any doubt the confirmation of the first image of an exoplanet , around the star 2M1207 (see ESO PR 12/05). ESO's telescopes also found a Neptune-mass exoplanet around a small star ( PR 30/05) - a discovery that proves crucial in the census of other planetary systems, and imaged a tiny companion in the close vicinity of the star GQ Lupi, a very young object still surrounded by a disc, with an age between 100,000 and 2 million years ( PR 09/05). Moreover, using a new high-contrast adaptive optics camera on the VLT, the NACO Simultaneous Differential Imager, or NACO SDI, astronomers were able for the first time to image a companion 120 times fainter than its star , very near the star AB Doradus A. This companion appears to be almost twice as heavy as theory predicts it to be ( PR 02/05). ESO's telescopes proved very useful in helping to solve a 30-year old puzzle . Astronomers have for the first time observed the visible light from a short gamma-ray burst (GRB). Using the 1.5m Danish telescope at La Silla (Chile), they showed that these short, intense bursts of gamma-ray emission most likely originate from the violent collision of two merging neutron stars ( PR 26/05). Additional evidence came from witnessing another event with the VLT ( PR 32/05). Also in this field, astronomers found the farthest known gamma-ray burst with ESO's VLT, observing an object with a redshift 6.3, i.e. that is seen when the Universe was less than 900 million years old ( PR 22/05). On July 4, NASA's Deep Impact spacecraft plunged onto Comet 9P/Tempel 1 with the aim to create a crater and expose pristine material from beneath the surface. For two days before and six days after, all major ESO telescopes have been observing the comet, in a coordinated fashion and in

  3. ESO PR Highlights in 2006

    Science.gov (United States)

    2007-01-01

    Last year proved to be another exceptional year for the European organisation for ground-based astronomy. ESO should begin the New Year with two new member states: Spain (PR 05/06) and the Czech Republic (PR 52/06). ESO PR Highlights 2006 2006 was a year of renovation and revolution in the world of planets. A new Earth-like exoplanet has been discovered (PR 03/06) using a network of telescopes from all over the world (including the Danish 1.54-m one at ESO La Silla). It is not the only child of this fruitful year: thanks to the combined use of ESO's Very Large Telescope (VLT) and La Silla instruments, a surprising system of twin giant exoplanets was found (PR 29/06), and a trio of Neptune-like planets hosted by a nearby star were identified (PR 18/06). These results open new perspectives on the search for habitable zones and on the understanding of the mechanism of planet formation. The VISIR instrument on the VLT has been providing unique information to answer this last question, by supplying a high resolution view of a planet-forming disc (PR 36/06). There are not only new members in the planets' register: during the General Assembly of the International Astronomical Union held in Prague (Czech Republic), it was decided that Pluto is not a planet anymore but a 'dwarf planet'. Whatever its status, Pluto still has a satellite, Charon, whose radius and density have been measured more accurately by observing a rare occultation from different sites, including Cerro Paranal (PR 02/06). The scientific community dedicated 2006 to the great physicist James Clerk Maxwell (it was the 175th anniversary of the birth): without his electromagnetic theory of light, none of the astonishing discoveries of modern physics could have been achieved. Nowadays we can look at distant galaxies in great detail: the GIRAFFE spectrograph on the VLT revealed that galaxies 6 billion years ago had the same amount of dark matter relative to stars than nowadays (PR 10/06), while SINFONI gave an

  4. Ultrabass Sounds of the Giant Star xi Hya

    Science.gov (United States)

    2002-05-01

    First Observations of Solar-type Oscillations in a Star Very Different from the Sun Summary About 30 years ago, astronomers realised that the Sun resonates like a giant musical instrument with well-defined periods (frequencies). It forms a sort of large, spherical organ pipe. The energy that excites these sound waves comes from the turbulent region just below the Sun's visible surface. Observations of the solar sound waves (known as " helioseismology ") have resulted in enormous progress in the exploration of the interior of the Sun, otherwise hidden from view. As is the case on Earth, seismic techniques can be applied and the detailed interpretation of the observed oscillation periods has provided quite accurate information about the structure and motions inside the Sun, our central star. It has now also become possible to apply this technique to some solar-type stars. The first observations concerned the northern star eta Bootis (cf. ESO PR 16/94 ). Last year, extensive and much more accurate observations with the 1.2-m Swiss telescope at the ESO La Silla Observatory proved that Alpha Centauri , a solar "twin", behaves very much like the Sun (cf. ESO PR 15/01 ), and that some of the periods are quite similar to those in the Sun. These new observational data were of a superb quality, and that study marked a true break-through in the new research field of " asteroseismology " (seismology of the stars) for solar-type stars. But what about other types of stars, for instance those that are much larger than the Sun? Based on an extremely intensive observing project with the same telescope, an international group of astronomers [1] has found that the giant star xi Hya ("xi" is the small greek letter [2]; "Hya" is an abbreviation of "Hydrae") behaves like a giant sub-ultra-bass instrument . This star is located in the constellation Hydra (the Water-Monster) at a distance of 130 light-years, it has a radius about 10 times that of the Sun and its luminosity is about 60

  5. Spain to Join ESO

    Science.gov (United States)

    2006-02-01

    Today, during a ceremony in Madrid, an agreement was signed by the Spanish Minister of Education and Science, Mrs. María Jesús San Segundo, and the ESO Director General, Dr. Catherine Cesarsky, affirming their commitment to securing Spanish membership of ESO. ESO PR Photo 05a/06 ESO PR Photo 05a/06 Signature Event in Madrid Following approval by the Spanish Council of Ministers and the ratification by the Spanish Parliament of the ESO Convention and the associated protocols, Spain intends to become ESO's 12th member state on 1 July 2006. "Since long Spain was aware that entering ESO was a logical decision and it was even necessary for a country like Spain because Spain is ranked 8th in astrophysical research", said Mrs. María Jesús San Segundo. "The large scientific installations are not only necessary for research in different fields but are also partners and customers for hi-tech companies, helping to increase the funding of R&D." "Spanish Astronomy has made tremendous strides forward and we are delighted to welcome Spain as a new member of ESO. We very much look forward to working together with our excellent Spanish colleagues," said Dr. Cesarsky. "For ESO, the Spanish accession means that we can draw on the scientific and technological competences, some of them unique in Europe, that have been developed in Spain and, of course, for Europe the Spanish membership of ESO is an important milestone in the construction of the European Research Area." ESO PR Photo 05b/06 ESO PR Photo 05b/06 Signature Event in Madrid Indeed, Spain is an important member of the European astronomical community and has developed impressively over the last three decades, reaching maturity with major contributions in virtually all subjects of astronomy. In addition, Spain hosts, operates or owns a number of competitive facilities dedicated to foster astronomical research, among which the Observatorio del Roque de los Muchachos at La Palma, certainly the premier optical

  6. ESO Highlights in 2008

    Science.gov (United States)

    2009-01-01

    As is now the tradition, the European Southern Observatory looks back at the exciting moments of last year. 2008 was in several aspects an exceptionally good year. Over the year, ESO's telescopes provided data for more than 700 scientific publications in refereed journals, making ESO the most productive ground-based observatory in the world. ESO PR Highlights 2008 ESO PR Photo 01a/09 The image above is a clickable map. These are only some of the press releases issued by ESO in 2008. For a full listing, please go to ESO 2008 page. Austria signed the agreement to join the other 13 ESO member states (ESO 11/08 and 20/08), while the year marked the 10th anniversary of first light for ESO's "perfect science machine", the Very Large Telescope (ESO 16/08 and 17/08). The ALMA project, for which ESO is the European partner, had a major milestone in December, as the observatory was equipped with its first antenna (ESO 49/08). Also the Atacama Pathfinder Experiment (APEX) telescope impressed this year with some very impressive and publicly visible results. Highlights came in many fields: Astronomers for instance used the Very Large Telescope (VLT) to discover and image a probable giant planet long sought around the star Beta Pictoris (ESO 42/08). This is now the eighth extrasolar planet to have been imaged since the VLT imaged the first extrasolar planet in 2004 (three of eight were imaged with VLT). The VLT also enabled three students to confirm the nature of a unique planet (ESO 45/08). This extraordinary find, which turned up during their research project, is a planet about five times as massive as Jupiter. This is the first planet discovered orbiting a fast-rotating hot star. The world's foremost planet-hunting instrument, HARPS, located at ESO's La Silla observatory, scored a new first, finding a system of three super-Earths around a star (ESO 19/08). Based on the complete HARPS sample, astronomers now think that one Sun-like star out of three harbours short orbit, low

  7. Estadística pràctica per a alumnes de 4t d’ESO

    OpenAIRE

    Camprodon Masnou, Jordi

    2012-01-01

    Malgrat que l’estadística està en un dels millors moments respecte l’ensenyament universitari, no es pot dir el mateix en el cas de l’ESO; a la gran majoria d’Instituts els alumnes acaben l’ensenyament obligatori havent vist molt poca estadística. Són moltes les possibles causes d’aquest fet, però les més importants podrien ser que la bibliografia existent redueix l’interès dels alumnes i que l’estadística té una escassa aparició a la Selectivitat. En aquest treball presentem un dossier...

  8. Finland to Join ESO

    Science.gov (United States)

    2004-02-01

    Finland will become the eleventh member state of the European Southern Observatory (ESO) [1]. Today, during a ceremony at the ESO Headquarters in Garching (Germany), a corresponding Agreement was signed by the Finnish Minister of Education and Science, Ms. Tuula Haatainen and the ESO Director General, Dr. Catherine Cesarsky, in the presence of other high officials from Finland and the ESO member states (see Video Clip 02/04 below). Following subsequent ratification by the Finnish Parliament of the ESO Convention and the associated protocols [2], it is foreseen that Finland will formally join ESO on July 1, 2004. Uniting European Astronomy ESO PR Photo 03/04 ESO PR Photo 03/04 Caption : Signing of the Finland-ESO Agreement on February 9, 2004, at the ESO Headquarters in Garching (Germany). At the table, the ESO Director General, Dr. Catherine Cesarsky, and the Finnish Minister of Education and Science, Ms. Tuula Haatainen . [Preview - JPEG: 400 x 499 pix - 52k] [Normal - JPEG: 800 x 997 pix - 720k] [Full Res - JPEG: 2126 x 2649 pix - 2.9M] The Finnish Minister of Education and Science, Ms. Tuula Haatainen, began her speech with these words: "On behalf of Finland, I am happy and proud that we are now joining the European Southern Observatory, one of the most successful megaprojects of European science. ESO is an excellent example of the potential of European cooperation in science, and along with the ALMA project, more and more of global cooperation as well." She also mentioned that besides science ESO offers many technological challenges and opportunities. And she added: "In Finland we will try to promote also technological and industrial cooperation with ESO, and we hope that the ESO side will help us to create good working relations. I am confident that Finland's membership in ESO will be beneficial to both sides." Dr. Catherine Cesarsky, ESO Director General, warmly welcomed the Finnish intention to join ESO. "With the accession of their country to ESO, Finnish

  9. Eso's Situation in Chile

    Science.gov (United States)

    1995-02-01

    elements of Chilean labour legislation into its rules and regulations for local staff. These proposed actions are contained in an Amendment to the Convention which was initialled late last year and is now awaiting signature by the Chilean Government and ratification by the Chilean Congress, as well as by the ESO Council. FUTURE INFORMATION In conjunction with the present Press Release ESO has prepared a pre-edited video-news reel with video-clips (approx. 4 minutes) about Paranal and the current work there. It is available for TV channels in the usual formats (Beta-SP and M II). Please fax your request to the ESO Information Service (+4989-3202362). ESO will continue to keep the media informed about further important developments around the VLT Project, in addition to the usual scientific and technological news, available through Press Releases and the ESO house journal, "The Messenger/El Mensajero". ----- Notes: [1] See also the following ESO Press Releases: PR 14/94 of 29 September 1994, PR 13/94 of 9 August 1994; PR 12/94 of 10 June 1994; PR 08/94 of 5 May 1994, and PR 07/94 of 21 April 1994. [2] The Council of ESO consists of two representatives from each of the eight member states. It is the highest legislative authority of the organisation and normally meets twice a year. ----- ESO Press Information is made available on the World-Wide Web (URL: http://www.hq.eso.org/) and on CompuServe (space science and astronomy area, GO SPACE).

  10. Portugal to Accede to ESO

    Science.gov (United States)

    2000-06-01

    The Republic of Portugal will become the ninth member state of the European Southern Observatory (ESO) [1]. Today, during a ceremony at the ESO Headquarters in Garching (Germany), a corresponding Agreement was signed by the Portuguese Minister of Science and Technology, José Mariano Gago and the ESO Director General, Catherine Cesarsky , in the presence of other high officials from Portugal and the ESO member states (see Video Clip 05/00 below). Following subsequent ratification by the Portuguese Parliament of the ESO Convention and the associated protocols [2], it is foreseen that Portugal will formally join this organisation on January 1, 2001. Uniting European Astronomy ESO PR Photo 16/00 ESO PR Photo 16/00 [Preview - JPEG: 400 x 405 pix - 160k] [Normal - JPEG: 800 x 809 pix - 408k] Caption : Signing of the Portugal-ESO Agreement on June 27, 2000, at the ESO Headquarters in Garching (Germany). At the table, the ESO Director General, Catherine Cesarsky , and the Portuguese Minister of Science and Technology, José Mariano Gago . In his speech, the Portuguese Minister of Science and Technology, José Mariano Gago , stated that "the accession of Portugal to ESO is the result of a joint effort by ESO and Portugal during the last ten years. It was made possible by the rapid Portuguese scientific development and by the growth and internationalisation of its scientific community." He continued: "Portugal is fully committed to European scientific and technological development. We will devote our best efforts to the success of ESO". Catherine Cesarsky , ESO Director General since 1999, warmly welcomed the Portuguese intention to join ESO. "With the accession of their country to ESO, Portuguese astronomers will have great opportunities for working on research programmes at the frontiers of modern astrophysics." "This is indeed a good time to join ESO", she added. "The four 8.2-m VLT Unit Telescopes with their many first-class instruments are nearly ready, and the VLT

  11. ESO Delegation to Visit Chile: the Chile-Eso Treaty and Paranal

    Science.gov (United States)

    1994-05-01

    The ESO Council, in its extraordinary session on 28 April 1994, among other matters discussed the relations with the Republic of Chile and the situation around Paranal mountain [1], the designated site for the ESO Very Large Telescope (VLT). Council decided to send a high ranking delegation to Santiago de Chile to discuss with Chilean authorities the pending problems, including the finalisation of the new Treaty between the Republic of Chile and ESO and the legal aspects of the Paranal location. The ESO delegation will consist of Dr. Peter Creola (President of ESO Council), Dr. Catherine Cesarsky (Vice-President of ESO Council), Dr. Henrik Grage (Former Vice-President of ESO Council) and Professor Riccardo Giacconi (ESO Director General), the latter accompanied by his advisers. The delegation will arrive in Chile during the second half of May 1994. The ESO delegation will meet with the Chilean Minister of Foreign Affairs, Mr. Carlos Figueroa, and the Secretary of State in the Ministry of Foreign Affairs, Mr. Jose Miguel Insulza. Other meetings at high level are being planned. The delegation will report about these discussions to the ESO Council during its ordinary session on 7 - 8 June 1994. FOUR PARANAL PHOTOS AVAILABLE A series of four photos which show the current status of the work at Paranal has been prepared. Photographic colour prints for use by the media can be requested from the ESO Information and Photographic Service (please remember to indicate the identification numbers). [1] See ESO Press Release 07/94 of 21 April 1994. PHOTO CAPTIONS ESO PR PHOTO 08/94-1: CERRO PARANAL This aerial photo of the Paranal mountain, the designated site for the ESO Very Large Telescope (VLT), was obtained on 22 March 1994. Paranal is situated in the driest part of the Chilean Atacama desert, approx. 130 km south of the city of Antofagasta, and about 12 km from the Pacific Ocean. In this view towards the West, the ocean is seen in the background. The altitude is 2650 metres

  12. Public surveys at ESO

    Science.gov (United States)

    Arnaboldi, Magda; Delmotte, Nausicaa; Hilker, Michael; Hussain, Gaitee; Mascetti, Laura; Micol, Alberto; Petr-Gotzens, Monika; Rejkuba, Marina; Retzlaff, Jörg; Mieske, Steffen; Szeifert, Thomas; Ivison, Rob; Leibundgut, Bruno; Romaniello, Martino

    2016-07-01

    ESO has a strong mandate to survey the Southern Sky. In this article, we describe the ESO telescopes and instruments that are currently used for ESO Public Surveys, and the future plans of the community with the new wide-field-spectroscopic instruments. We summarize the ESO policies governing the management of these projects on behalf of the community. The on-going ESO Public Surveys and their science goals, their status of completion, and the new projects selected during the second ESO VISTA call in 2015/2016 are discussed. We then present the impact of these projects in terms of current numbers of refereed publications and the scientific data products published through the ESO Science Archive Facility by the survey teams, including the independent access and scientific use of the published survey data products by the astronomical community.

  13. Spitzer Spectroscopy of the Transition Object TW Hya

    Science.gov (United States)

    2010-02-24

    the [NeII] line profile of TW Hya, which shows a 6 km s−1 blueshift in the emission centroid, as indicating an origin in a low-velocity...of high velocity phenomena such as magnetospheric infall would be indicated. If the lines are nar- row (> 30 km s−1) and/or with a small blueshift

  14. W Hya: Molecular inventory by ISO-SWS

    NARCIS (Netherlands)

    Justtanont, K.; de Jong, T.; Tielens, A.G.G.M.; Feuchtgruber, H.; Waters, L.B.F.M.

    2004-01-01

    Infrared spectroscopy is a powerful tool to probe the inventory of solid state and molecular species in circumstellar ejecta. Here we analyse the infrared spectrum of the Asymptotic Giant Branch star W Hya, obtained by the Short and Long Wavelength Spectrometers on board of the Infrared Satellite Ob

  15. W Hya : Molecular inventory by ISO-SWS

    NARCIS (Netherlands)

    Justtanont, K; de Jong, T; Tielens, AGGM; Feuchtgruber, H; Waters, LBFM

    2004-01-01

    Infrared spectroscopy is a powerful tool to probe the inventory of solid state and molecular species in circumstellar ejecta. Here we analyse the infrared spectrum of the Asymptotic Giant Branch star W Hya, obtained by the Short and Long Wavelength Spectrometers on board of the Infrared Satellite Ob

  16. The wind of W Hya as seen by Herschel. II. The molecular envelope of W Hya

    CERN Document Server

    Khouri, T; Decin, L; Waters, L B F M; Maercker, M; Lombaert, R; Alcolea, J; Blommaert, J A D L; Bujarrabal, V; Groenewegen, M A T; Justtanont, K; Kerschbaum, F; Matsuura, M; Menten, K M; Olofsson, H; Planesas, P; Royer, P; Schmidt, M R; Szczerba, R; Teyssier, D; Yates, J

    2014-01-01

    The evolution of low- and intermediate-mass stars on the asymptotic giant branch (AGB) is mainly controlled by the rate at which these stars lose mass in a stellar wind. Understanding the driving mechanism and strength of the stellar winds of AGB stars and the processes enriching their surfaces with products of nucleosynthesis are paramount to constraining AGB evolution and predicting the chemical evolution of galaxies. In a previous paper we have constrained the structure of the outflowing envelope of W Hya using spectral lines of the $^{12}$CO molecule. Here we broaden this study by modelling an extensive set of H$_{2}$O and $^{28}$SiO lines observed by the three instruments on board Herschel using a state-of-the-art molecular excitation and radiative transfer code. The oxygen isotopic ratios and the $^{28}$SiO abundance profile can be connected to the initial stellar mass and to crucial aspects of dust formation at the base of the stellar wind, respectively. The modelling of H$_{2}$O and $^{28}$SiO confirm...

  17. ESO's First Observatory Celebrates 40th Anniversary

    Science.gov (United States)

    2009-03-01

    ESO's La Silla Observatory, which is celebrating its 40th anniversary, became the largest astronomical observatory of its time. It led Europe to the frontline of astronomical research, and is still one of the most scientifically productive in ground-based astronomy. ESO PR Photo 12a/09 La Silla Aerial View ESO PR Photo 12b/09 The ESO New Technology Telescope ESO PR Photo 12c/09 SEST on La Silla ESO PR Photo 12d/09 Looking for the best site ESO PR Video 12a/09 ESOcast 5 With about 300 refereed publications attributable to the work of the observatory per year, La Silla remains at the forefront of astronomy. It has led to an enormous number of scientific discoveries, including several "firsts". The HARPS spectrograph is the world's foremost exoplanet hunter. It detected the system around Gliese 581, which contains what may be the first known rocky planet in a habitable zone, outside the Solar System (ESO 22/07). Several telescopes at La Silla played a crucial role in discovering that the expansion of the Universe is accelerating (ESO 21/98) and in linking gamma-ray bursts -- the most energetic explosions in the Universe since the Big Bang - with the explosions of massive stars (ESO 15/98). Since 1987, the ESO La Silla Observatory has also played an important role in the study and follow-up of the nearest supernova, SN 1987A (ESO 08/07). "The La Silla Observatory continues to offer the astronomical community exceptional capabilities," says ESO Director General, Tim de Zeeuw. "It was ESO's first presence in Chile and as such, it triggered a very long and fruitful collaboration with this country and its scientific community." The La Silla Observatory is located at the edge of the Chilean Atacama Desert, one of the driest and loneliest areas of the world. Like other observatories in this geographical area, La Silla is located far from sources of polluting light and, as the Paranal Observatory that houses the Very Large Telescope, it has one of the darkest and clearest

  18. Southern Fireworks above ESO Telescopes

    Science.gov (United States)

    1999-05-01

    - the PLANET observers turned their telescope and quickly obtained a series of CCD images in visual light of the sky region where the gamma-ray burst was detected, then shipped them off electronically to their Dutch colleagues [3]. Comparing the new photos with earlier ones in the digital sky archive, Vreeswijk, Galama and Rol almost immediately discovered a new, relatively bright visual source in the region of the gamma-ray burst, which they proposed as the optical counterpart of the burst, cf. their dedicated webpage at http://www.astro.uva.nl/~titus/grb990510/. The team then placed a message on the international Gamma-Ray Burster web-noteboard ( GCN Circular 310), thereby alerting their colleagues all over the world. One hour later, the narrow-field instruments on BeppoSax identified a new X-Ray source at the same location ( GCN Circular 311), thus confirming the optical identification. All in all, a remarkable synergy of human and satellite resources! Observations of GRB 990510 at ESO Vreeswijk, Galama and Rol, in collaboration with Nicola Masetti, Eliana Palazzi and Elena Pian of the BeppoSAX GRB optical follow-up team (led by Filippo Frontera ) and the Huntsville optical follow-up team (led by Chryssa Kouveliotou ), also contacted the European Southern Observatory (ESO). Astronomers at this Organization's observatories in Chile were quick to exploit this opportunity and crucial data were soon obtained with several of the main telescopes at La Silla and Paranal, less than 14 hours after the first detection of this event by the satellite. ESO PR Photo 22a/99 ESO PR Photo 22a/99 [Preview - JPEG: 211 x 400 pix - 72k] [Normal - JPEG: 422 x 800 pix - 212k] [High-Res - JPEG: 1582 x 3000 pix - 2.6M] ESO PR Photo 22b/99 ESO PR Photo 22b/99 [Preview - JPEG: 400 x 437 pix - 297k] [Normal - JPEG: 800 x 873 pix - 1.1M] [High-Res - JPEG: 2300 x 2509 pix - 5.9M] Caption to PR Photo 22a/99 : This wide-field photo was obtained with the Wide-Field Imager (WFI) at the MPG/ESO 2.2-m

  19. Volatile-carbon locking and release in protoplanetary disks. A study of TW Hya and HD 100546

    Science.gov (United States)

    Kama, M.; Bruderer, S.; van Dishoeck, E. F.; Hogerheijde, M.; Folsom, C. P.; Miotello, A.; Fedele, D.; Belloche, A.; Güsten, R.; Wyrowski, F.

    2016-08-01

    Aims: The composition of planetary solids and gases is largely rooted in the processing of volatile elements in protoplanetary disks. To shed light on the key processes, we carry out a comparative analysis of the gas-phase carbon abundance in two systems with a similar age and disk mass, but different central stars: HD 100546 and TW Hya. Methods: We combine our recent detections of C0 in these disks with observations of other carbon reservoirs (CO, C+, C2H) and gas-mass and warm-gas tracers (HD, O0), as well as spatially resolved ALMA observations and the spectral energy distribution. The disks are modelled with the DALI 2D physical-chemical code. Stellar abundances for HD 100546 are derived from archival spectra. Results: Upper limits on HD emission from HD 100546 place an upper limit on the total disk mass of ≤0.1 M⊙. The gas-phase carbon abundance in the atmosphere of this warm Herbig disk is, at most, moderately depleted compared to the interstellar medium, with [C]/[H]gas = (0.1-1.5) × 10-4. HD 100546 itself is a λBoötis star, with solar abundances of C and O but a strong depletion of rock-forming elements. In the gas of the T Tauri disk TW Hya, both C and O are strongly underabundant, with [C]/[H]gas = (0.2-5.0) × 10-6 and C / O > 1. We discuss evidence that the gas-phase C and O abundances are high in the warm inner regions of both disks. Our analytical model, including vertical mixing and a grain size distribution, reproduces the observed [C]/[H]gas in the outer disk of TW Hya and allows to make predictions for other systems. Based on observations collected at the European Organisation for Astronomical Research in the Southern Hemisphere under ESO programmes 093.C-0926, 093.F-0015, 077.D-0092, 084.A-9016, and 085.A-9027.Spectra and models are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/592/A83

  20. ESO and Chile: 10 Years of Productive Scientific Collaboration

    Science.gov (United States)

    2006-06-01

    ESO and the Government of Chile launched today the book "10 Years Exploring the Universe", written by the beneficiaries of the ESO-Chile Joint Committee. This annual fund provides grants for individual Chilean scientists, research infrastructures, scientific congresses, workshops for science teachers and astronomy outreach programmes for the public. In a ceremony held in Santiago on 19 June 2006, the European Organisation for Astronomical Research in the Southern Hemisphere (ESO) and the Chilean Ministry of Foreign Affairs marked the 10th Anniversary of the Supplementary Agreement, which granted to Chilean astronomers up to 10 percent of the total observing time on ESO telescopes. This agreement also established an annual fund for the development of astronomy, managed by the so-called "ESO-Chile Joint Committee". ESO PR Photo 21/06 ESO PR Photo 21/06 Ten Years ESO-Chile Agreement Ceremony The celebration event was hosted by ESO Director General, Dr. Catherine Cesarsky, and the Director of Special Policy for the Chilean Ministry of Foreign Affairs, Ambassador Luis Winter. "ESO's commitment is, and always will be, to promote astronomy and scientific knowledge in the country hosting our observatories", said ESO Director General, Dr. Catherine Cesarsky. "We hope Chile and Europe will continue with great achievements in this fascinating joint adventure, the exploration of the universe." On behalf of the Government of Chile, Ambassador Luis Winter outlined the historical importance of the Supplementary Agreement, ratified by the Chilean Congress in 1996. "Such is the magnitude of ESO-Chile Joint Committee that, only in 2005, this annual fund represented 8 percent of all financing sources for Chilean astronomy, including those from Government and universities", Ambassador Winter said. The ESO Representative and Head of Science in Chile, Dr. Felix Mirabel, and the appointed Chilean astronomer for the ESO-Chile Joint Committee, Dr. Leonardo Bronfman, also took part in the

  1. ESO: The CERN Years

    CERN Multimedia

    Schaeffer, A

    2012-01-01

    In 1970, CERN and ESO signed a collaboration agreement for the construction of the Observatory’s first telescope. That same year, ESO’s Telescope Division and Sky Atlas laboratory settled on the CERN site in Meyrin. Let’s turn back to the beginnings of this lasting and fruitful alliance.

  2. Spitzer Spectroscopy of the Transition Object TW Hya

    CERN Document Server

    Najita, Joan R; Strom, Stephen E; Watson, Dan M; Pascucci, Ilaria; Hollenbach, David; Gorti, Uma; Keller, Luke

    2010-01-01

    We report sensitive Spitzer IRS spectroscopy in the 10-20 micron region of TW Hya, a nearby T Tauri star. The unusual spectral energy distribution of the source, that of a transition object, indicates that the circumstellar disk in the system has experienced significant evolution, possibly as a result of planet formation. The spectrum we measure is strikingly different from that of other classical T Tauri stars reported in the literature, displaying no strong emission features of water, acetylene, or HCN. The difference indicates that the inner planet formation region (within 5 AU) of the gaseous disk has evolved physically and/or chemically away from the classical T Tauri norm. Nevertheless, TW Hya does show a rich spectrum of emission features of atoms (HI, [NeII], and [NeIII]) and molecules (H2, OH, CO2, HCO+, and possibly CH3), some of which are also detected in classical T Tauri spectra. The properties of the neon emission are consistent with an origin for the emission in a disk irradiated by X-rays (wit...

  3. ESO's Two Observatories Merge

    Science.gov (United States)

    2005-02-01

    On February 1, 2005, the European Southern Observatory (ESO) has merged its two observatories, La Silla and Paranal, into one. This move will help Europe's prime organisation for astronomy to better manage its many and diverse projects by deploying available resources more efficiently where and when they are needed. The merged observatory will be known as the La Silla Paranal Observatory. Catherine Cesarsky, ESO's Director General, comments the new development: "The merging, which was planned during the past year with the deep involvement of all the staff, has created unified maintenance and engineering (including software, mechanics, electronics and optics) departments across the two sites, further increasing the already very high efficiency of our telescopes. It is my great pleasure to commend the excellent work of Jorge Melnick, former director of the La Silla Observatory, and of Roberto Gilmozzi, the director of Paranal." ESO's headquarters are located in Garching, in the vicinity of Munich (Bavaria, Germany), and this intergovernmental organisation has established itself as a world-leader in astronomy. Created in 1962, ESO is now supported by eleven member states (Belgium, Denmark, Finland, France, Germany, Italy, The Netherlands, Portugal, Sweden, Switzerland, and the United Kingdom). It operates major telescopes on two remote sites, all located in Chile: La Silla, about 600 km north of Santiago and at an altitude of 2400m; Paranal, a 2600m high mountain in the Atacama Desert 120 km south of the coastal city of Antofagasta. Most recently, ESO has started the construction of an observatory at Chajnantor, a 5000m high site, also in the Atacama Desert. La Silla, north of the town of La Serena, has been the bastion of the organization's facilities since 1964. It is the site of two of the most productive 4-m class telescopes in the world, the New Technology Telescope (NTT) - the first major telescope equipped with active optics - and the 3.6-m, which hosts HARPS

  4. Predicting Complex Organic Molecule Emission from TW Hya

    Science.gov (United States)

    Vissapragada, Shreyas; Walsh, Catherine

    2017-01-01

    The Atacama Large Millimeter/submillimeter Array (ALMA) has significantly increased our ability to observe the rich chemical inventory of star and planet formation. ALMA has recently been used to detect CH3OH (methanol) and CH3CN (methyl cyanide) in protoplanetary disks; these molecules may be vital indicators of the complex organic ice reservoir in the comet-forming zone. We have constructed a physiochemical model of TW Hya, a well-studied protoplanetary disk, to explore the different formation mechanisms of complex ices. By running our model through a radiative transfer code and convolving with beam sizes appropriate for ALMA, we have obtained synthetic observations of methanol and methyl cyanide. Here, we compare and comment on these synthetic observations, and provide astrochemical justification for their spatial distributions.

  5. VizieR Online Data Catalog: LQ Hya activity and Li variations (Flores Soriano+, 2015)

    Science.gov (United States)

    Flores Soriano, M.; Strassmeier, K. G.; Weber, M.

    2015-01-01

    We preset in these two tables the observing log and the numerical results of the spectral analysis of LQ Hya. They are a tabular version of the results shown in the figures of the paper. (2 data files).

  6. 1970: ESO arrives at CERN

    CERN Multimedia

    Anaïs Schaeffer

    2012-01-01

    In 1970, CERN and ESO signed a collaboration agreement for the construction of the Observatory’s first telescope. That same year, ESO’s Telescope Division and Sky Atlas laboratory settled on the CERN site in Meyrin. Let’s turn back to the beginnings of this lasting and fruitful alliance.   Martin Cullum, ESO physicist from 1973 to 2009 In 1974, when I attended my first international conference on behalf of ESO, the first thing people asked was: “Where are you from?” “ESO,” I would say. The response: ‘'What on Earth is ESO?” Nowadays, people I meet seem to know more about ESO than I do! It is clear that ESO profited enormously from its sojourn at CERN. The wise decision of the ESO Director General at the time, Adriaan Blaauw, to move to Geneva allowed ESO to build up its technical expertise to be able to build world-beating projects like the VLT, which has undoubtedly been the most exciting scientif...

  7. Acciones tutoriales a implantar para incidir en la relación entre práctica de botellón y resultados académicos en 3º de ESO

    OpenAIRE

    Berguilla Andión, Iker

    2013-01-01

    RESUMEN Se ha llevado a cabo una investigación acerca de la relación existente entre practicar botellón y el rendimiento académico en los alumnos de los dos grupos de 3º ESO de un I.E.S de Cantabria. Se trata de un estudio descriptivo de tipo cuantitativo con un tamaño de muestra de 52 alumnos para el que se ha empleado un cuestionario como instrumento de recogida de datos y que tiene como objetivo poder planificar de un modo más eficaz las actividades a desarrollar en la asignatura de tutorí...

  8. ESO adaptive optics facility

    Science.gov (United States)

    Arsenault, R.; Madec, P.-Y.; Hubin, N.; Paufique, J.; Stroebele, S.; Soenke, C.; Donaldson, R.; Fedrigo, E.; Oberti, S.; Tordo, S.; Downing, M.; Kiekebusch, M.; Conzelmann, R.; Duchateau, M.; Jost, A.; Hackenberg, W.; Bonaccini Calia, D.; Delabre, B.; Stuik, R.; Biasi, R.; Gallieni, D.; Lazzarini, P.; Lelouarn, M.; Glindeman, A.

    2008-07-01

    ESO has initiated in June 2004 a concept of Adaptive Optics Facility. One unit 8m telescope of the VLT is upgraded with a 1.1 m convex Deformable Secondary Mirror and an optimized instrument park. The AO modules GALACSI and GRAAL will provide GLAO and LTAO corrections forHawk-I and MUSE. A natural guide star mode is provided for commissioning and maintenance at the telescope. The facility is completed by a Laser Guide Star Facility launching 4 LGS from the telescope centerpiece used for the GLAO and LTAO wavefront sensing. A sophisticated test bench called ASSIST is being designed to allow an extensive testing and characterization phase of the DSM and its AO modules in Europe. Most sub-projects have entered the final design phase and the DSM has entered Manufacturing phase. First light is planned in the course of 2012 and the commissioning phases should be completed by 2013.

  9. Quality initiative at ESO

    Science.gov (United States)

    Rupprecht, Gero; Arsenault, Robin; Hanuschik, Reinhard; Kraus, Maximilian; Sivera, Paola; Tromp, Arnout; Verzichelli, Gianluca

    2016-08-01

    An initiative is under way at ESO Headquarters to optimise operations, in particular in the engineering, technical and associated management areas. A systematic approach to strengthen the operating processes is in preparation, starting with a mapping of the extensive existing process network. Processes identified as sufficiently important and complex to merit an in-depth analysis will be properly specified and their implementation optimised to strike a sensible balance between organisational overhead (documentation) and efficiency. By applying methods and tools tried and tested in industry we expect to achieve a more unified approach to address recurrent tasks. This will enable staff to concentrate more on new challenges and improvement and avoid spending effort on issues already resolved in the past.

  10. ESO and NSF Sign Agreement on ALMA

    Science.gov (United States)

    2003-02-01

    that we will be able to study and understand our universe in ways that have previously been beyond our vision". The recent Presidential decree from Chile for AUI and the agreement signed in late 2002 between ESO and the Government of the Republic of Chile (cf. ESO PR 18/02) recognize the interest that the ALMA Project has for Chile, as it will deepen and strengthen the cooperation in scientific and technological matters between the parties. A joint ALMA Board has been established which oversees the realisation of the ALMA project via the management structure. This Board meets for the first time on February 24-25, 2003, at NSF in Washington and will witness this historic event. ALMA: Imaging the Light from Cosmic Dawn ESO PR Photo 06a/03 ESO PR Photo 06a/03 [Preview - JPEG: 588 x 400 pix - 52k [Normal - JPEG: 1176 x 800 pix - 192k] [Hi-Res - JPEG: 3300 x 2244 pix - 2.0M] ESO PR Photo 06b/03 ESO PR Photo 06b/03 [Preview - JPEG: 502 x 400 pix - 82k [Normal - JPEG: 1003 x 800 pix - 392k] [Hi-Res - JPEG: 2222 x 1773 pix - 3.0M] ESO PR Photo 06c/03 ESO PR Photo 06c/03 [Preview - JPEG: 474 x 400 pix - 84k [Normal - JPEG: 947 x 800 pix - 344k] [Hi-Res - JPEG: 2272 x 1920 pix - 2.0M] ESO PR Photo 06d/03 ESO PR Photo 06d/03 [Preview - JPEG: 414 x 400 pix - 69k [Normal - JPEG: 828 x 800 pix - 336k] [HiRes - JPEG: 2935 x 2835 pix - 7.4k] Captions: PR Photo 06a/03 shows an artist's view of the Atacama Large Millimeter Array (ALMA), with 64 12-m antennae. PR Photo 06b/03 is another such view, with the array arranged in a compact configuration at the high-altitude Chajnantor site. The ALMA VertexRSI prototype antennae is shown in PR Photo 06c/03 on the Antenna Test Facility (ATF) site at the NRAO Very Large Array (VLA) site near Socorro (New Mexico, USA). The future ALMA site at Llano de Chajnantor at 5000 metre altitude, some 40 km East of the village of San Pedro de Atacama (Chile) is seen in PR Photo 06d/03 - this view was obtained at 11 hrs in the morning on a crisp and clear

  11. TW Hya: Spectral Variability, X-Rays, and Accretion Diagnostics

    CERN Document Server

    Dupree, A K; Cranmer, S R; Luna, G J M; Schneider, E E; Bessell, M S; Bonanos, A; Crause, L A; Lawson, W A; Mallik, S V; Schuler, S C

    2012-01-01

    The nearest accreting T Tauri star, TW Hya was observed with spectroscopic and photometric measurements simultaneous with a long se gmented exposure using the CHANDRA satellite. Contemporaneous optical photometry from WASP-S indicates a 4.74 day period was present during this time. Absence of a similar periodicity in the H-alpha flux and the total X-ray flux points to a different source of photometric variations. The H-alpha emission line appears intrinsically broad and symmetric, and both the profile and its variability suggest an origin in the post-shock cooling region. An accretion event, signaled by soft X-rays, is traced spectroscopically for the first time through the optical emission line profiles. After the accretion event, downflowing turbulent material observed in the H-alpha and H-beta lines is followed by He I (5876A) broadening. Optical veiling increases with a delay of about 2 hours after the X-ray accretion event. The response of the stellar coronal emission to an increase in the veiling follow...

  12. W Hya molecular inventory by ISO-SWS

    CERN Document Server

    Justtanont, K; Tielens, A G G M; Feuchtgruber, H; Waters, L B F M

    2004-01-01

    Infrared spectroscopy is a powerful tool to probe the inventory of solid state and molecular species in circumstellar ejecta. Here we analyse the infrared spectrum of the Asymptotic Giant Branch star W Hya, obtained by the Short and Long Wavelength Spectrometers on board of the Infrared Satellite Observatory. These spectra show evidence for the presence of amorphous silicates, aluminum oxide, and magnesium-iron oxide grains. We have modelled the spectral energy distribution using laboratory measured optical properties of these compounds and derive a total dust mass loss rate of 3E-10 Msol/yr. We find no satisfactory fit to the 13 micron dust emission feature and the identification of its carrier is still an open issue. We have also modelled the molecular absorption bands due to H2O, OH, CO, CO2, SiO, and SO2 and estimated the excitation temperatures for different bands which range from 300 to 3000K. It is clear that different molecules giving rise to these absorption bands originate from different gas layers....

  13. Doppler Imaging of LQ Hya for 1998-2002

    CERN Document Server

    Cole, E M; Käpylä, M J; Ilyin, I; Kochukhov, O; Piskunov, N

    2015-01-01

    We study the spot distribution on the surface of LQ~Hya during the observing seasons October 1998 -- November 2002. We look for persistent active longitudes, trends in the level of spot activity and compare to photometric data, specifically to the derived time epochs of the lightcurve minima. We apply the Doppler Imaging technique on photospheric spectral lines using an inversion code to retrieve images of the surface temperature. We present new temperature maps using multiple spectral lines for a total of 7 seasons. We calculate spot coverage fractions from each map, and as a result we find a general trend that is interpreted to be an indication of a spot cycle. There is a minimum during the observing season of March 1999. After this the activity increases until November 2000, followed by a general decrease in activity again. We find no evidence for active longitudes persisting over multiple observing seasons. The spot activity appears to be concentrated to two latitude regions. The high latitude spots are p...

  14. Time-Variable Accretion in the TW Hya Star/Disk System

    CERN Document Server

    Eisner, J A; Najita, J R; McCarthy, D; Kulesa, C; Swift, B J; Teske, J

    2010-01-01

    We present two epochs of observations of TW Hya from the high-dispersion near-IR spectrograph ARIES at the MMT. We detect strong emission from the Brackett gamma transition of hydrogen, indicating an accretion rate substantially larger than previously estimated using hydrogen line emission. The Brackett gamma line-strength varies across our two observed epochs. We also measure circumstellar-to-stellar flux ratios (i.e., veilings) that appear close to zero in both epochs. These findings suggest that TW Hya experiences episodes of enhanced accretion while the inner disk remains largely devoid of dust. We discuss several physical mechanisms that may explain these observations.

  15. Dutch Minister of Science Visits ESO Facilities in Chile

    Science.gov (United States)

    2005-05-01

    ," expressed Mrs. Maria van der Hoeven during her visit. "An almost unique level of international cooperation is achieved at ESO, and everything is done by those who can do it best, irrespective of their country or institution. This spirit of excellence is an example for all Europe, notably for the new European Research Council." Catherine Cesarsky, ESO Director General, remarked that Dutch astronomers have been part of ESO from the beginning: "The Dutch astronomy community and industry play a major role in various aspects of the Very Large Telescope, and more particularly in its interferometric mode. With their long-based expertise in radio astronomy, Dutch astronomers greatly contribute in this field, and are now also playing a major role in the construction of ALMA. It is thus a particularly great pleasure to receive Her Excellency, Mrs. Maria van der Hoeven." ESO PR Photo 16d/05 ESO PR Photo 16d/05 Dutch Minister Maria van der Hoeven at Chajnantor - I [Preview - JPEG: 400 x 480 pix - 207k] [Normal - JPEG: 800 x 959 pix - 617k] ESO PR Photo 16e/05 ESO PR Photo 16e/05 Dutch Minister Maria van der Hoeven at Chajnantor - II [Preview - JPEG: 400 x 605 pix - 179k] [Normal - JPEG: 800 x 1210 pix - 522k] Caption: ESO PR Photo 16d/05: In front of the APEX antenna at Chajnantor. From left to right: Prof. Piet van der Kruit, Mrs. Maria van der Hoeven, Prof. Tim de Zeeuw, and Prof. Ewine van Dishoeck. ESO PR Photo 16e/05 shows the Delegation on the 5000m high Llano de Chajnantor plateau. From left to right: Dr. Leo Le Duc, Prof. Felix Mirabel, Prof. Tim de Zeeuw, Prof. Ewine van Dishoeck, Dr. Cornelius van Bochove, Mrs. Maria van der Hoeven, Mr. Hans van der Vlies, Dr. Joerg Eschwey, Mr. Hinkinus Nijenhuis, Prof. Piet van der Kruit, Mr. Hans van den Broek, and Mr. Eduardo Donoso. The delegation spent the night at the Observatory before heading further North in the Chilean Andes to San Pedro de Atacama and from there to the Operation Support Facility of the future ALMA Observatory. On

  16. W Hya: Molecular inventory by ISO-SWS

    Science.gov (United States)

    Justtanont, K.; de Jong, T.; Tielens, A. G. G. M.; Feuchtgruber, H.; Waters, L. B. F. M.

    2004-04-01

    Infrared spectroscopy is a powerful tool to probe the inventory of solid state and molecular species in circumstellar ejecta. Here we analyse the infrared spectrum of the Asymptotic Giant Branch star W Hya, obtained by the Short and Long Wavelength Spectrometers on board of the Infrared Satellite Observatory. These spectra show evidence for the presence of amorphous silicates, aluminum oxide, and magnesium-iron oxide grains. We have modelled the spectral energy distribution using laboratory-measured optical properties of these compounds and derive a total dust mass-loss rate of 3× 10-10 M⊙ yr-1. We find no satisfactory fit to the 13 μm dust emission feature and the identification of its carrier is still an open issue. We have also modelled the molecular absorption bands due to H2O, OH, CO, CO2, SiO, and SO2 and estimated the excitation temperatures for different bands which range from 300 to 3000 K. It is clear that different molecules giving rise to these absorption bands originate from different gas layers. We present and analyse high-resolution Fabry-Perot spectra of the three CO2 bands in the 15 μm region. In these data, the bands are resolved into individual Q-lines in emission, which allows the direct determination of the excitation temperature and column density of the emitting gas. This reveals the presence of a warm (≃450 K) extended layer of CO2, somewhere between the photosphere and the dust formation zone. The gas in this layer is cooler than the 1000 K CO2 gas responsible for the low-resolution absorption bands at 4.25 and 15 μm. The rotational and vibrational excitation temperatures derived from the individual Q-branch lines of CO2 are different (˜450 K and 150 K, respectively) so that the CO2 level population is not in LTE. Based on observations with ISO, an ESA project with instruments funded by ESA Member States (especially the PI countries: France, Germany, The Netherlands and the UK) with the participation of ISAS and NASA.

  17. The short-chain oxidoreductase Q9HYA2 from Pseudomonas aeruginosa PAO1 contains an atypical catalytic center.

    Science.gov (United States)

    Huether, Robert; Mao, Qilong; Duax, William L; Umland, Timothy C

    2010-05-01

    The characteristic oxidation or reduction reaction mechanisms of short-chain oxidoreductase (SCOR) enzymes involve a highly conserved Asp-Ser-Tyr-Lys catalytic tetrad. The SCOR enzyme Q9HYA2 from the pathogenic bacterium Pseudomonas aeruginosa was recognized to possess an atypical catalytic tetrad composed of Lys118-Ser146-Thr159-Arg163. Orthologs of Q9HYA2 containing the unusual catalytic tetrad along with conserved substrate and cofactor recognition residues were identified in 27 additional species, the majority of which are bacterial pathogens. However, this atypical catalytic tetrad was not represented within the Protein Data Bank. The crystal structures of unligated and NADPH-complexed Q9HYA2 were determined at 2.3 A resolution. Structural alignment to a polyketide ketoreductase (KR), a typical SCOR, demonstrated that Q9HYA2's Lys118, Ser146, and Arg163 superimposed upon the KR's catalytic Asp114, Ser144, and Lys161, respectively. However, only the backbone of Q9HYA2's Thr159 overlapped KR's catalytic Tyr157. The Thr159 hydroxyl in apo Q9HYA2 is poorly positioned for participating in catalysis. In the Q9HYA2-NADPH complex, the Thr159 side chain was modeled in two alternate rotamers, one of which is positioned to interact with other members of the tetrad and the bound cofactor. A chloride ion is bound at the position normally occupied by the catalytic tyrosine hydroxyl. The putative active site of Q9HYA2 contains a chemical moiety at each catalytically important position of a typical SCOR enzyme. This is the first observation of a SCOR protein with this alternate catalytic center that includes threonine replacing the catalytic tyrosine and an ion replacing the hydroxyl moiety of the catalytic tyrosine.

  18. Blockbuster starring ESO Paranal opens tomorrow

    Science.gov (United States)

    2008-10-01

    The 22nd James Bond adventure is due for release tomorrow, 31 October 2008, in the UK and a week later in the rest of the world. A key location in the movie is the Residencia, the hotel for astronomers and staff at ESO's Paranal Observatory. Blockbuster starring ESO Paranal opens tomorrow ESO PR Photo 38/08 The James Bond "Quantum of Solace" filmmakers Quantum of Solace is the latest film in one of most successful movie franchises -- that of renowned 007 Agent James Bond of the British Secret Service MI6. The agent "on Her Majesty's secret service" is once again played by Daniel Craig. Key scenes of the movie were filmed at Paranal, the home of ESO's Very Large Telescope, and the most advanced optical telescope in the world. Usually occupied by no more than 100 astronomers, engineers and technicians, Paranal welcomed the 300-strong film crew for several days of shooting at the end of March 2008. The crew travelled from their hotel base in Antofagasta for up to two hours each morning to reach the filming locations. "We are delighted to have a movie like this filmed at Paranal and it was extremely good to see how careful the crew were with the surroundings and how mindful they were of the fact that they were in an operating, working observatory", says Tim de Zeeuw, ESO Director General. "Paranal is a unique observatory in a unique setting and it is no real surprise that it plays a major part in a James Bond movie", he adds. The filmmakers were mostly interested in filming exterior scenes at the Paranal Residencia, the accommodation for staff operating the Very Large Telescope. In the movie, the Residencia is supposedly the "Perla de Las Dunas", a unique hotel in the desert. Cerro Paranal is a 2600 m high mountain in the Chilean Atacama Desert, perhaps the driest on Earth. The high altitude site and extreme dryness make excellent conditions for astronomical observations. To make it possible for people to live and work here, a hotel, or Residencia, was built at the

  19. Report on the 2009 ESO Fellows Symposium

    Science.gov (United States)

    Emsellem, Eric; West, Michael; Leibundgut, Bruno

    2009-09-01

    The fourth ESO Fellows Symposium took place in Garching from 8-10 June 2009. This year's symposium brought together 28 ESO Fellows from Chile and Germany to meet their colleagues from across the ocean, discuss their research and provide feedback on ESO's Fellowship programme. This year's symposium also included training workshops to enhance the practical skills of ESO Fellows in today's competitive job market.

  20. 果胶酶高产菌Aspergillus niger HYA4的选育%Breeding of high yield strain Aspergillus nigerHYA4 for pectinase

    Institute of Scientific and Technical Information of China (English)

    田英华; 刘晓兰; 邓永平

    2005-01-01

    采用紫外线处理黑曲霉(Aspergillus niger)HY4孢子,照射剂量为75s.获得一株高产果胶酶突变株HYA4,在优化的固体发酵条件下酶活力达1285U/g物料,比出发菌株提高了2倍,为亚麻脱胶酶的生产提供了良好的菌株.

  1. Rings of C2H in the Molecular Disks Orbiting TW Hya and V4046 Sgr

    CERN Document Server

    Kastner, J H; Gorti, U; Hily-Blant, P; Oberg, K; Forveille, T; Andrews, S; Wilner, D

    2015-01-01

    We have used the Submillimeter Array to image, at ~1" resolution, C2H(3-2) emission from the molecule-rich circumstellar disks orbiting the nearby, classical T Tauri star systems TW Hya and V4046 Sgr. The SMA imaging reveals that the C2H emission exhibits a ring-like morphology within each disk, the inner hole radius of the C2H ring within the V4046 Sgr disk (~70 AU) is somewhat larger than than of its counterpart within the TW Hya disk (~45 AU). We suggest that, in each case, the C2H emission likely traces irradiation of the tenuous surface layers of the outer disks by high-energy photons from the central stars.

  2. Resolving asymmetries along the pulsation cycle of the Mira star X Hya

    CERN Document Server

    Haubois, X; Perrin, G; Kervella, P; Mérand, A; Thiébaut, E; Ridgway, S T; Ireland, M; Scholz, M

    2015-01-01

    The mass-loss process in Mira stars probably occurs in an asymmetric way where dust can form in inhomogeneous circumstellar molecular clumps. Following asymmetries along the pulsation cycle can give us clues about these mass-loss processes. We imaged the Mira star X Hya and its environnement at different epochs to follow the evolution of the morphology in the continuum and in the molecular bands. We observed X Hya with AMBER in J-H-K at low resolution at two epochs. We modelled squared visibilities with geometrical and physical models. We also present imaging reconstruction results obtained with MiRA and based on the physical a priori images. We report on the angular scale change of X Hya between the two epochs. 1D CODEX profiles allowed us to understand and model the spectral variation of squared visibilities and constrain the stellar parameters. Reconstructed model-dependent images enabled us to reproduce closure phase signals and the azimuthal dependence of squared visibilities. They show evidence for mate...

  3. The ESO Educational Office Reaches Out towards Europe's Teachers

    Science.gov (United States)

    2001-12-01

    ESA/ESO Astronomy Exercises Provide a Taste of Real Astronomy [1] Summary The European Southern Observatory (ESO) has been involved in many Europe-wide educational projects during the past years, in particular within European Science Weeks sponsored by the European Commission (EC). In order to further enhance the significant educational potential inherent in the numerous scientific endeavours now carried out by Europe's astronomers with ESO front-line telescope facilities, it has been decided to set up an Educational Office within the ESO EPR Department. It will from now on work closely with astronomy-oriented teachers, in particular at the high-school level , providing support, inspiration and new materials. Much of this interaction will happen via the European Association for Astronomy Education (EAAE) In this context, and in collaboration with the European Space Agency (ESA) , the first instalments of the "ESA/ESO Astronomy Exercise Series" have just been published, on the web ( http://www.astroex.org ) and in print (6 booklets totalling 100 pages; provided free-of-charge to teachers on request). They allow 16-19 year old students to gain exciting hands-on experience in astronomy, making realistic calculations with data obtained from observations by some of the world's best telescopes, the NASA/ESA Hubble Space Telescope (HST) and ESO's Very Large Telescope (VLT) . PR Photo 36/01 : The "ESA/ESO Astronomy Exercise Series" . Educational projects at ESO The European Southern Observatory (ESO) , through its Education and Public Relations Department (EPR) , has long been involved in educational activities, in particular by means of Europe-wide projects during successive European Science Weeks , with support from the European Commission (EC) . A most visible outcome has been the creation of the trailblazing European Association for Astronomy Education (EAAE) - this was first discussed at an international meeting at the ESO Headquarters in November 1994 with the

  4. CCD data reductions at ESO

    Science.gov (United States)

    Grosbol, Preben

    The image-processing and data-reduction functions of the IHAP and MIDAS software packages developed at ESO for CCD astronomy are briefly reviewed. IHAP and MIDAS perform the same basic operations on HP 1000 and VAX computers, respectively, and MIDAS is currently being modified to run in the UNIX operating system as well as in VAX VMS. Consideration is given to the special properties of CCD data, the removal of gross errors (due to bad pixels and cosmic-ray events), photometric correction for dark current and sensitivity variations, digital filtering and Fourier transforms, detection and classification algorithms for direct imaging, surface photometry of extended objects, function fitting, and image deconvolution.

  5. Identification and Studies of a Rice Mutant hya-1 with Semi-dwarf and Aneuploid Traits%一份水稻半矮秆非整倍突变体hya-1的鉴定与研究

    Institute of Scientific and Technical Information of China (English)

    郭涛; 刘永柱; 张建国; 陈志强; 王慧

    2012-01-01

    A semi-dwarfing rice mutant hya-1 , genetically unstable in plant height was obtained through space muta-genesis of Texianzhan 13. Compared to the wild type, hya-1 mutant was featured by semi-dwarfness, fewer tillers, slim culms, reduced grain number per panicle, low seed setting rate and low germination rate. Segregation of plant height in selfed progenies of the mutant was observed. Normal plants of selfed progenies, however, showed genetic stability. Plant height of F, hybrid and F2 progenies generated from the cross between hya-1 mutant and Texianzhan 13 did not follow Mendelian inheritance. Furthermore, selfed-progenies of the mutant had abnormal chromosome numbers (e.g. 2n = 22, 23, 25 and 36 instead of 2n- 24). In addition, there were some pollen mother cells of hya-1 with 11 bivalents at the diakinesis stage of meiosis. Real-time quantitative PCR analysis of normal and semi-dwarf plants from selfed progenies of the mutant along with Texianzhan 13 showed equal copy number of chromosome in normal and wild type plants while the copy number of chromosome 8 and 11 differed in hya-1 and semi-dwarf plants from the selfed progenies. It suggested that hya-1 mutant is a new aneuploid in which abnormal phenotype and genetic instability are caused by abnormal chromosome number and/or varying copy number of certain chromosomes.%通过空间诱变得到半矮秆突变体hya-1,该突变体半矮秆性状遗传稳定性丧失.与其野生型特籼占13相比,hya-1株高显著降低、分蘖少、茎秆细弱、每穗粒数减少、结实率降低、发芽率降低.单株收获半矮株hya-1自交种子,对半矮生性状进行连续选择,发现该性状无法纯合稳定,自交群体株高长期分离(半矮秆和野生型);分离群体中的野生型个体自交,其株高性状稳定.利用hya-1与特籼占13配制杂交组合,其F1及F2株高表型不符合孟德尔分离规律.hya-1自交收获种子根尖细胞染色体数目出现了 2n=22、23、24、25、36的变

  6. ESO Imaging Survey AXAF Field

    CERN Document Server

    Rengelink, R B; Da Costa, L N; Zaggia, S R; Erben, T; Benoist, C; Wicenec, A; Scodeggio, M; Olsen, L F; Guarnieri, D; Deul, E; Hook, R N; Moorwood, A F M; Slijkhuis, R

    1998-01-01

    This paper presents ground-based data obtained from deep optical and infrared observations carried out at the ESO 3.5 New Technology Telescope (NTT) of a field selected for its low HI content for deep observations with AXAF. These data were taken as part of the ESO Imaging Survey (EIS) program, a public survey conducted in preparation for the first year of operation of the VLT. Deep CCD images are available for five optical passbands, reaching 2 sigma limiting magnitudes of U_AB~27.0, B_AB~27, V_AB~26.5, R_AB~26.5 and I_AB~26. An area of ~56 square arcmin is covered by UBVR observations, and ~30 square arcmin also in I. The infrared observations cover a total area of ~83 square arcmin, reaching J_AB~24.5 and K_AB~23.5. This paper describes the observations and data reduction. It also presents images of the surveyed region and lists the optical and infrared photometric parameters of the objects detected on the co-added images of each passband, as well as multicolor optical and infrared catalogs. These catalogs...

  7. Surface differential rotation of IL Hya from time-series Doppler images

    CERN Document Server

    Kővári, Zsolt; Oláh, Katalin; Vida, Krisztián; Bartus, János; Strassmeier, Klaus G; Weber, Michael

    2013-01-01

    We present a time-series Doppler imaging study of the K-subgiant component in the RS CVn-type binary system IL Hya (P orb=12.905 d). From re-processing the unique long-term spectroscopic dataset of 70 days taken in 1996/97, we perform a thorough cross-correlation analysis to derive surface differential rotation. As a result we get solar-type differential rotation with a shear value alpha of 0.05, in agreement with preliminary suggestions from previous attempts. A possible surface pattern of meridional circulation is also detected.

  8. Influence of starvation and feeding on the hepatopancreas of larval Hyas araneus (Decapoda, Majidae)

    Science.gov (United States)

    Storch, V.; Anger, K.

    1983-03-01

    Zoea-1 larvae of Hyas araneus were kept under different nutritional conditions. Their midgut glands were investigated with a transmission electron microscope. The glandular epithelium consists of the cell types known from adult decapods. It is mainly the R-cell type that undergoes ultrastructural alterations which reflect nutritional conditions. R-cells of fed larvae are characterized by large lipid inclusions; after a certain period of food deprivation (point-of-no-return) the original ultrastructure cannot be reestablished. Refeeding results in large glycogen deposits in these cells.

  9. The wind of W Hya as seen by Herschel - I. The CO envelope

    CERN Document Server

    Khouri, T; Decin, L; Waters, L B F M; Lombaert, R; Royer, P; Swinyard, B; Barlow, M J; Alcolea, J; Blommaert, J A D L; Bujarrabal, V; Cernicharo, J; Groenewegen, M A T; Justtanont, K; Kerschbaum, F; Maercker, M; Marston, A; Matsuura, M; Melnick, G; Menten, K M; Olofsson, H; Planesas, P; Polehampton, E; Posch, Th; Schmidt, M; Szczerba, R; Vandenbussche, B; Yates, J

    2014-01-01

    Asymptotic giant branch (AGB) stars lose their envelopes by means of a stellar wind whose driving mechanism is not understood well. Characterizing the composition and thermal and dynamical structure of the outflow provides constraints that are essential for understanding AGB evolution, including the rate of mass loss and isotopic ratios. We modeled the CO emission from the wind of the low mass-loss rate oxygen-rich AGB star W Hya using data obtained by the HIFI, PACS, and SPIRE instruments onboard the Herschel Space Observatory and ground-based telescopes. $^{12}$CO and $^{13}$CO lines are used to constrain the intrinsic $^{12}$C/$^{13}$C ratio from resolved HIFI lines. The acceleration of the outflow up to about 5.5 km/s is quite slow and can be represented by a beta-type velocity law with index 5. Beyond this point, acceleration up the terminal velocity of 7 km/s is faster. Using the J=10-9, 9-8, and 6-5 transitions, we find an intrinsic $^{12}$C/$^{13}$C ratio of $18\\pm10$ for W Hya, where the error bar is...

  10. Chemical abundance analysis of symbiotic giants. RW Hya, SY Mus, BX Mon, and AE Ara

    CERN Document Server

    Galan, Cezary; Hinkle, Kenneth H; Schmidt, Miroslaw R; Gromadzki, Mariusz

    2014-01-01

    Symbiotic stars are the long period, binary systems of strongly interacting stars at the final stages of evolution which can be useful tool to understand the chemical evolution of the Galaxy and the formation of stellar populations. Knowledge of the chemical composition of the symbiotic giants is essential to advancing our understanding of these issues but unfortunately reliably determinations exist only in a few cases. We perform a program for detailed chemical composition analysis in over 30 symbiotic giants, based on the high resolution, near-IR spectra, obtained with Phoenix/Gemini South spectrometer. The methods of the standard LTE analysis is used to obtain photospheric abundances of CNO and elements around iron peak. Here we present results obtained for four objects: RW Hya, SY Mus, BX Mon, and AE Ara. Our analysis revealed a significantly sub-solar metallicity (Me/H ~ -0.75) for RW Hya, a slightly sub-solar metallicities (Me/H ~ 0.2-0.3) in BX Mon and AE Ara, and a near-solar metallicity in SY Mus. 12...

  11. Chasing Shadows: Rotation of the Azimuthal Asymmetry in the TW Hya Disk

    Science.gov (United States)

    Debes, John H.; Poteet, Charles A.; Jang-Condell, Hannah; Gaspar, Andras; Hines, Dean; Kastner, Joel H.; Pueyo, Laurent; Rapson, Valerie; Roberge, Aki; Schneider, Glenn; hide

    2017-01-01

    We have obtained new images of the protoplanetary disk orbiting TW Hya in visible, total intensity light with the Space Telescope Imaging Spectrograph (STIS) on the Hubble Space Telescope (HST), using the newly commissioned BAR5 occulter. These HSTSTIS observations achieved an inner working angle of approximately 0 "2, or11.7 au, probing the system at angular radii coincident with recent images of the disk obtained by ALMA and in polarized intensity near-infrared light. By comparing our new STIS images to those taken with STIS in 2000 and with NICMOS in 1998, 2004, and 2005, we demonstrate that TW Hyas azimuthal surface brightness asymmetry moves coherently in position angle. Between 50 au and 141 au we measure a constant angular velocity in the azimuthal brightness asymmetry of 22.deg7 yr(exp -1) in a counterclockwise direction, equivalent to a period of 15.9yrassuming circular motion. Both the (short) inferred period and lack of radial dependence of the moving shadow pattern are inconsistent with Keplerian rotation at these disk radii. We hypothesize that the asymmetry arises from the fact that the disk interior to 1 au is inclined and precessing owing to a planetary companion, thus partially shadowing the outer disk. Further monitoring of this and other shadows on protoplanetary disks potentially opens anew avenue for indirectly observing the sites of planet formation.

  12. Impact of anthropogenic ocean acidification on thermal tolerance of the spider crab Hyas araneus

    Directory of Open Access Journals (Sweden)

    H. O. Pörtner

    2009-03-01

    Full Text Available Future scenarios project combined developments of elevated CO2 concentrations and global warming and their impact on marine ecosystems. The synergistic impact of both factors was addressed by studying the effect of CO2 accumulation on thermal tolerance of the cold-eurythermal spider crab Hyas araneus. Animals were exposed to present day normocapnia (380 ppm CO2, CO2 levels expected towards 2100 (710 ppm and beyond (3000 ppm. Heart rate and haemolymph PO2 (PeO2 were measured during progressive short term cooling from 10 to 0°C and during warming from 10 to 25°C. An increase of PeO2 occurred during cooling with highest values reached at 0°C under all three CO2 levels. Heart rate increased during warming until a critical temperature (Tc was reached. The putative Tc under normocapnia was presumably >25°C, from where it fell to 23.5°C under 710 ppm and then 21.1°C under 3000 ppm. At the same time, thermal sensitivity, as seen in the Q10 values of heart rate, rose with increasing CO2 concentration in the warmth. Our results suggest a narrowing of the thermal window of Hyas araneus under moderate increases in CO2 levels by exacerbation of the heat or cold induced oxygen and capacity limitation of thermal tolerance.

  13. Urine antibody against human cancer antigen NY-ESO-1

    OpenAIRE

    Jäger, Dirk; Stockert, Elisabeth; Karbach, Julia; Herrlinger, Kristina; Atmaca, Akin; Arand, Michael; Chen, Yao-Tseng; Gnjatic, Sacha; Old, Lloyd J.; Knuth, Alexander; Jäger, Elke

    2002-01-01

    NY-ESO-1 is one of the most immunogenic tumor antigens known to date. Spontaneous humoral and cellular immune responses against NY-ESO-1 are detected in a substantial proportion of patients with NY-ESO-1 positive cancers. NY-ESO-1 serum antibody is dependent on the presence of NY-ESO-1+ cancer cells, and antibody titers correlate with the clinical development of the disease. NY-ESO-1 serum antibody is associated with detectable NY-ESO-1-specific CD8+ T cell reactivity. High titers of NY-ESO-1...

  14. Herschel-PACS observation of the 10 Myr old T Tauri disk TW Hya: Constraining the disk gas mass

    CERN Document Server

    Thi, W F; Ménard, F; Woitke, P; Meeus, G; Riviere-Marichalar, P; Pinte, C; Howard, C D; Roberge, A; Sandell, G; Pascucci, I; Riaz, B; Grady, C A; Dent, W R F; Kamp, I; Duchêne, G; Augereau, J C; Pantin, E; Vandenbussche, B; Tilling, I; Williams, J P; Eiroa, C; Barrado, D; Alacid, J M; Andrews, S; Ardila, D R; Aresu, G; Brittain, S; Ciardi, D R; Danchi, W; Fedele, D; de Gregorio-Monsalvo, I; Heras, A; Huelamo, N; Krivov, A; Lebreton, J; Liseau, R; Martin-Zaidi, C; Mendigutía, I; Montesinos, B; Mora, A; Morales-Calderon, M; Nomura, H; Phillips, N; Podio, L; Poelman, D R; Ramsay, S; Rice, K; Solano, E; Walker, H; White, G J; Wright, G

    2010-01-01

    Planets are formed in disks around young stars. With an age of ~10 Myr, TW Hya is one of the nearest T Tauri stars that is still surrounded by a relatively massive disk. In addition a large number of molecules has been found in the TW Hya disk, making TW Hya the perfect test case in a large survey of disks with Herschel-PACS to directly study their gaseous component. We aim to constrain the gas and dust mass of the circumstellar disk around TW Hya. We observed the fine-structure lines of [OI] and [CII] as part of the Open-time large program GASPS. We complement this with continuum data and ground-based 12CO 3-2 and 13CO 3-2 observations. We simultaneously model the continuum and the line fluxes with the 3D Monte-Carlo code MCFOST and the thermo-chemical code ProDiMo to derive the gas and dust masses. We detect the [OI] line at 63 micron. The other lines that were observed, [OI] at 145 micron and [CII] at 157 micron, are not detected. No extended emission has been found. Preliminary modeling of the photometric...

  15. CCDs at ESO: A Systematic Testing Program

    Science.gov (United States)

    Abbott, T. M. C.; Warmels, R. H.

    ESO currently offers a stable of 12 CCDs for use by visiting astronomers. It is incumbent upon ESO to ensure that these devices perform according to their advertised specifications (Abbott 1994). We describe a systematic, regular testing program for CCDs which is now being applied at La Silla. These tests are designed to expose failures which may not have catastrophic effects but which may compromise observations. The results of these tests are stored in an archive, accessible to visiting astronomers, and will be subject to trend analysis. The test are integrated in the CCD reduction package of the Munich Image Data Analysis System (ESO-MIDAS).

  16. Cloning and molecular characterization of BmHYA1, a novel hyaluronidase from the venom of Chinese red scorpion Buthus martensi Karsch.

    Science.gov (United States)

    Feng, Luo; Gao, Rong; Meng, Jun; Gopalakrishnakone, Ponnampalam

    2010-09-01

    In this communication, the full protein sequence of a novel venom hyaluronidase BmHYA1 was reported. It is the first full hyaluronidase amino acid sequence from scorpion venom. It was deduced from nucleotide sequence by 3' Rapid Amplification of cDNA Ends (RACE) PCR cloning, followed by alignment with the N-terminal amino acid sequence, which was obtained by Edman degradation. BmHYA1 has 385 amino acid residues containing five potential N-glycosylation sites. The phylogenetic analysis indicates early divergence and independent evolution of BmHYA1 from other hyaluronidases.

  17. Report on the ESO Data Simulation Workshop

    Science.gov (United States)

    Ballester, P.

    2016-06-01

    The role of simulated data is increasing rapidly across all phases of instrumentation projects, from design to scientific exploitation. The many commonalities among ESO instruments, their reduction software and archival products, makes it especially worthwhile to exchange knowledge between their instrument teams. The data simulation workshop was the first of its kind to bring together the ESO instrument simulator community and a brief overview of the workshop is presented. The participants expressed strong interest in continuing to exchange knowledge in this area.

  18. Using ESO Reflex with Web Services

    Science.gov (United States)

    Järveläinen, P.; Savolainen, V.; Oittinen, T.; Maisala, S.; Ullgrén, M. Hook, R.

    2008-08-01

    ESO Reflex is a prototype graphical workflow system, based on Taverna, and primarily intended to be a flexible way of running ESO data reduction recipes along with other legacy applications and user-written tools. ESO Reflex can also readily use the Taverna Web Services features that are based on the Apache Axis SOAP implementation. Taverna is a general purpose Web Service client, and requires no programming to use such services. However, Taverna also has some restrictions: for example, no numerical types such integers. In addition the preferred binding style is document/literal wrapped, but most astronomical services publish the Axis default WSDL using RPC/encoded style. Despite these minor limitations we have created simple but very promising test VO workflow using the Sesame name resolver service at CDS Strasbourg, the Hubble SIAP server at the Multi-Mission Archive at Space Telescope (MAST) and the WESIX image cataloging and catalogue cross-referencing service at the University of Pittsburgh. ESO Reflex can also pass files and URIs via the PLASTIC protocol to visualisation tools and has its own viewer for VOTables. We picked these three Web Services to try to set up a realistic and useful ESO Reflex workflow. They also demonstrate ESO Reflex abilities to use many kind of Web Services because each of them requires a different interface. We describe each of these services in turn and comment on how it was used

  19. KINEMATICS OF THE CO GAS IN THE INNER REGIONS OF THE TW Hya DISK

    Energy Technology Data Exchange (ETDEWEB)

    Rosenfeld, Katherine A.; Qi Chunhua; Andrews, Sean M.; Wilner, David J. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Corder, Stuartt A. [National Radio Astronomy Observatory, 520 Edgemont Road, Charlottesville, VA 22903 (United States); Dullemond, C. P. [Institut fuer Theoretische Astrophysik, Universitaet Heidelberg, Albert-Ueberle-Str. 2, D-69120 Heidelberg (Germany); Lin Shinyi [Department of Physics, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 (United States); Hughes, A. M. [Department of Astronomy, University of California at Berkeley, 601 Campbell Hall, Berkeley, CA 94720 (United States); D' Alessio, Paola [Centro de Radioastronomia y Astrofisica, Universidad Nacional Autonoma de Mexico, Apartado Postal 72-3 (Xangari), 58089 Morelia, Michoacan (Mexico); Ho, P. T. P. [Academia Sinica Institute of Astronomy and Astrophysics, P.O. Box 23-141, Taipei 106, Taiwan (China)

    2012-10-01

    We present a detailed analysis of the spatially and spectrally resolved {sup 12}CO J = 2-1 and J = 3-2 emission lines from the TW Hya circumstellar disk, based on science verification data from the Atacama Large Millimeter/submillimeter Array (ALMA). These lines exhibit substantial emission in their high-velocity wings (with projected velocities out to 2.1 km s{sup -1}, corresponding to intrinsic orbital velocities >20 km s{sup -1}) that trace molecular gas as close as 2 AU from the central star. However, we are not able to reproduce the intensity of these wings and the general spatio-kinematic pattern of the lines with simple models for the disk structure and kinematics. Using three-dimensional non-local thermodynamic equilibrium molecular excitation and radiative transfer calculations, we construct some alternative models that successfully account for these features by modifying either (1) the temperature structure of the inner disk (inside the dust-depleted disk cavity; r < 4 AU), (2) the intrinsic (Keplerian) disk velocity field, or (3) the distribution of disk inclination angles (a warp). The latter approach is particularly compelling because a representative warped disk model qualitatively reproduces the observed azimuthal modulation of optical light scattered off the disk surface. In any model scenario, the ALMA data clearly require a substantial molecular gas reservoir located inside the region where dust optical depths are known to be substantially diminished in the TW Hya disk, in agreement with previous studies based on infrared spectroscopy. The results from these updated model prescriptions are discussed in terms of their potential physical origins, which might include dynamical perturbations from a low-mass companion with an orbital separation of a few AU.

  20. Impact of anthropogenic ocean acidification on thermal tolerance of the spider crab Hyas araneus

    Directory of Open Access Journals (Sweden)

    H. O. Pörtner

    2009-10-01

    Full Text Available Future scenarios for the oceans project combined developments of CO2 accumulation and global warming and their impact on marine ecosystems. The synergistic impact of both factors was addressed by studying the effect of elevated CO2 concentrations on thermal tolerance of the cold-eurythermal spider crab Hyas araneus from the population around Helgoland. Here ambient temperatures characterize the southernmost distribution limit of this species. Animals were exposed to present day normocapnia (380 ppm CO2, CO2 levels expected towards 2100 (710 ppm and beyond (3000 ppm. Heart rate and haemolymph PO2 (PeO2 were measured during progressive short term cooling from 10 to 0°C and during warming from 10 to 25°C. An increase of PeO2 occurred during cooling, the highest values being reached at 0°C under all three CO2 levels. Heart rate increased during warming until a critical temperature (Tc was reached. The putative Tc under normocapnia was presumably >25°C, from where it fell to 23.5°C under 710 ppm and then 21.1°C under 3000 ppm. At the same time, thermal sensitivity, as seen in the Q10 values of heart rate, rose with increasing CO2 concentration in the warmth. Our results suggest a narrowing of the thermal window of Hyas araneus under moderate increases in CO2 levels by exacerbation of the heat or cold induced oxygen and capacity limitation of thermal tolerance.

  1. UK Announces Intention to Join ESO

    Science.gov (United States)

    2000-11-01

    Summary The Particle Physics and Astronomy Research Council (PPARC) , the UK's strategic science investment agency, today announced that the government of the United Kingdom is making funds available that provide a baseline for this country to join the European Southern Observatory (ESO) . The ESO Director General, Dr. Catherine Cesarsky , and the ESO Community warmly welcome this move towards fuller integration in European astronomy. "With the UK as a potential member country of ESO, our joint opportunities for front-line research and technology will grow significantly", she said. "This announcement is a clear sign of confidence in ESO's abilities, most recently demonstrated with the construction and operation of the unique Very Large Telescope (VLT) on Paranal. Together we will look forward with confidence towards new, exciting projects in ground-based astronomy." It was decided earlier this year to place the 4-m UK Visible and Infrared Survey Telescope (VISTA) at Paranal, cf. ESO Press Release 03/00. Following negotiations between ESO and PPARC, a detailed proposal for the associated UK/ESO Agreement with the various entry modalities will now be presented to the ESO Council for approval. Before this Agreement can enter into force, the ESO Convention and associated protocols must also be ratified by the UK Parliament. Research and key technologies According to the PPARC press release, increased funding for science, announced by the UK government today, will enable UK astronomers to prepare for the next generation of telescopes and expand their current telescope portfolio through membership of the European Southern Observatory (ESO). The uplift to its baseline budget will enable PPARC to enter into final negotiations for UK membership of the ESO. This will ensure that UK astronomers, together with their colleagues in the ESO member states, are actively involved in global scale preparations for the next generation of astronomy facilities. among these are ALMA

  2. ESO's Hidden Treasures Brought to Light

    Science.gov (United States)

    2011-01-01

    ESO's Hidden Treasures 2010 astrophotography competition attracted nearly 100 entries, and ESO is delighted to announce the winners. Hidden Treasures gave amateur astronomers the opportunity to search ESO's vast archives of astronomical data for a well-hidden cosmic gem. Astronomy enthusiast Igor Chekalin from Russia won the first prize in this difficult but rewarding challenge - the trip of a lifetime to ESO's Very Large Telescope at Paranal, Chile. The pictures of the Universe that can be seen in ESO's releases are impressive. However, many hours of skilful work are required to assemble the raw greyscale data captured by the telescopes into these colourful images, correcting them for distortions and unwanted signatures of the instrument, and enhancing them so as to bring out the details contained in the astronomical data. ESO has a team of professional image processors, but for the ESO's Hidden Treasures 2010 competition, the experts decided to give astronomy and photography enthusiasts the opportunity to show the world what they could do with the mammoth amount of data contained in ESO's archives. The enthusiasts who responded to the call submitted nearly 100 entries in total - far exceeding initial expectations, given the difficult nature of the challenge. "We were completely taken aback both by the quantity and the quality of the images that were submitted. This was not a challenge for the faint-hearted, requiring both an advanced knowledge of data processing and an artistic eye. We are thrilled to have discovered so many talented people," said Lars Lindberg Christensen, Head of ESO's education and Public Outreach Department. Digging through many terabytes of professional astronomical data, the entrants had to identify a series of greyscale images of a celestial object that would reveal the hidden beauty of our Universe. The chance of a great reward for the lucky winner was enough to spur on the competitors; the first prize being a trip to ESO's Very Large

  3. Herschel-PACS observation of the 10 Myr old T Tauri disk TW Hya. Constraining the disk gas mass

    Science.gov (United States)

    Thi, W.-F.; Mathews, G.; Ménard, F.; Woitke, P.; Meeus, G.; Riviere-Marichalar, P.; Pinte, C.; Howard, C. D.; Roberge, A.; Sandell, G.; Pascucci, I.; Riaz, B.; Grady, C. A.; Dent, W. R. F.; Kamp, I.; Duchêne, G.; Augereau, J.-C.; Pantin, E.; Vandenbussche, B.; Tilling, I.; Williams, J. P.; Eiroa, C.; Barrado, D.; Alacid, J. M.; Andrews, S.; Ardila, D. R.; Aresu, G.; Brittain, S.; Ciardi, D. R.; Danchi, W.; Fedele, D.; de Gregorio-Monsalvo, I.; Heras, A.; Huelamo, N.; Krivov, A.; Lebreton, J.; Liseau, R.; Martin-Zaidi, C.; Mendigutía, I.; Montesinos, B.; Mora, A.; Morales-Calderon, M.; Nomura, H.; Phillips, N.; Podio, L.; Poelman, D. R.; Ramsay, S.; Rice, K.; Solano, E.; Walker, H.; White, G. J.; Wright, G.

    2010-07-01

    Planets are formed in disks around young stars. With an age of ~10 Myr, TW Hya is one of the nearest T Tauri stars that is still surrounded by a relatively massive disk. In addition a large number of molecules has been found in the TW Hya disk, making TW Hya the perfect test case in a large survey of disks with Herschel-PACS to directly study their gaseous component. We aim to constrain the gas and dust mass of the circumstellar disk around TW Hya. We observed the fine-structure lines of [O i] and [C ii] as part of the open-time large program GASPS. We complement this with continuum data and ground-based 12 CO 3-2 and 13CO 3-2 observations. We simultaneously model the continuum and the line fluxes with the 3D Monte-Carlo code MCFOST and the thermo-chemical code ProDiMo to derive the gas and dust masses. We detect the [O i] line at 63 μm. The other lines that were observed, [O i] at 145 μm and [C ii] at 157 μm, are not detected. No extended emission has been found. Preliminary modeling of the photometric and line data assuming [ 12CO] /[ 13CO] = 69 suggests a dust mass for grains with radius <1 mm of ~1.9 × 10-4 M⊙ (total solid mass of 3 × 10-3 M⊙) and a gas mass of (0.5-5) × 10-3 M⊙. The gas-to-dust mass may be lower than the standard interstellar value of 100. Herschel is an ESA space observatory with science instruments provided by Principal Investigator consortia. It is open for proposals for observing time from the worldwide astronomical community.Appendix is only available in electronic form at http://www.aanda.org

  4. UVES and X-Shooter spectroscopy of the emission line AM CVn systems GP Com and V396 Hya

    Science.gov (United States)

    Kupfer, T.; Steeghs, D.; Groot, P. J.; Marsh, T. R.; Nelemans, G.; Roelofs, G. H. A.

    2016-04-01

    We present time-resolved spectroscopy of the AM CVn-type binaries GP Com and V396 Hya obtained with VLT/X-Shooter and VLT/UV-Visual Echelle Spectrograph (UVES). We fully resolve the narrow central components of the dominant helium lines and determine radial velocity semi-amplitudes of Kspike = 11.7 ± 0.3 km s-1 for GP Com and Kspike = 5.8 ± 0.3 km s-1 for V396 Hya. The mean velocities of the narrow central components show variations from line to line. Compared to calculated line profiles that include Stark broadening we are able to explain the displacements, and the appearance of forbidden helium lines, by additional Stark broadening of emission in a helium plasma with an electron density ne ≃ 5 × 1015 cm-3. More than 30 nitrogen and more than 10 neon lines emission lines were detected in both systems. Additionally, 20 nitrogen absorption lines are only seen in GP Com. The radial velocity variations of these lines show the same phase and velocity amplitude as the central helium emission components. The small semi-amplitude of the central helium emission component, the consistency of phase and amplitude with the absorption components in GP Com as well as the measured Stark effect shows that the central helium emission component, the so-called central-spike, is consistent with an origin on the accreting white dwarf. We use the dynamics of the bright spot and the central-spike to constrain the binary parameters for both systems and find a donor mass of 9.6-42.8 MJupiter for GP Com and 6.1-30.5 MJupiter for V396 Hya. We find an upper limit for the rotational velocity of the accretor of vrot < 46 km s-1 for GP Com and vrot < 59 km s-1 for V396 Hya which excludes a fast rotating accretor in both systems.

  5. WISEA J114724.10-204021.3: A Free-Floating Planetary Mass Member of the TW Hya Association

    CERN Document Server

    Schneider, Adam C; Cushing, Michael C; Kirkpatrick, J Davy; Wright, Edward L

    2016-01-01

    We present WISEA J114724.10$-$204021.3, a young, low-mass, high probability member of the TW Hya association. WISEA J114724.10$-$204021.3 was discovered based on its red AllWISE color (W1$-$W2 = 0.63 mag) and extremely red 2MASS $J-K_{\\rm S}$ color ($>$ 2.64 mag), the latter of which is confirmed with near-infrared photometry from the VISTA Hemisphere Survey ($J-K_{\\rm S}$ = 2.57$\\pm$0.03). Follow-up near-infrared spectroscopy shows a spectral type of L7 $\\pm$ 1 as well as several spectroscopic indicators of youth. These include a peaked $H$-band shape and a steeper $K$-band slope, traits typically attributed to low surface gravity. The sky position, proper motion, and distance estimates of WISEA J114724.10$-$204021.3 are all consistent with membership in the $\\sim$10 Myr old TW Hya association. Using the age of the TW Hya association and evolutionary models, we estimate the mass of WISEA J114724.10$-$204021.3 to be 5$-$13 $M_{\\rm Jup}$, making it one of the youngest and lowest mass free-floating objects yet ...

  6. ESO-VLT Science Data Processing

    Science.gov (United States)

    Hanuschik, Reinhard; Data Processing; Quality Control Group

    2017-09-01

    "In the past three years the QC group at ESO has installed an efficient process to create science-grade data products from VLT instruments. With the focus on spectroscopic observations, these data products are complementary to the (externally provided) data products from the surveys. The production line combines efficient mass production (more than one million spectra have been generated so far), previews, and quality control. All data products are available to the community through the ESO archive interface. The talk will highlight the most recent addition, the MUSE datacubes."

  7. Catherine Cesarsky - ESO's Next Director General

    Science.gov (United States)

    1999-01-01

    The ESO Council has appointed Dr. Catherine Cesarsky as Director General for a five year period, succeeding Professor Riccardo Giacconi, whose term ends this year. Dr. Cesarsky will take up her duties on September 1, 1999, at the ESO Headquarters in Garching (Germany). Dr. Cesarsky was born in France in 1943. She received a degree in Physical Sciences at the University of Buenos Aires and graduated with a PhD in Astronomy in 1971 from Harvard University (Cambridge, Mass., USA). Afterwards she worked at the California Institute of Technology (CALTECH). In 1974, she became a staff member of the Service d'Astrophysique (SAp) , Direction des Sciences de la Matière (DSM), Commissariat à l'Energie Atomique (CEA) (France). She headed the theoretical group of the SAp (1978-1985), was Head of SAp (1985-1993) and has been Director of DSM since 1994. The DSM encompasses, at the CEA, activities of basic research in physics, chemistry, astrophysics and earth sciences and comprises about 3000 scientists, engineers, technicians, etc. Dr. Cesarsky is known for her successful research activities in several central areas of modern astrophysics. The first part of her career was devoted to the high-energy domain. This has involved studies of the propagation and composition of galactic cosmic rays, of matter and fields in the diffuse interstellar medium, as well as the acceleration of particles in astrophysical shocks, e.g. in connection with supernovae. She then turned to infrared astronomy. She is the Principal Investigator of the ISOCAM camera onboard the Infrared Space Observatory (ISO) of the European Space Agency (ESA) and, as such, she leads the ISOCAM central programme. It studies, in a coordinated way, the infrared emission from a variety of galactic and extragalactic sources and is yielding new and exciting results on star formation and galactic evolution. Dr. Cesarsky received the COSPAR (Committee on Space Research) Space Science Award in 1998. She is a member of many

  8. The Gaia-ESO Public Spectroscopic Survey

    DEFF Research Database (Denmark)

    Gilmore, G.; Randich, S.; Asplund, M.

    2012-01-01

    The Gaia-ESO Public Spectroscopic Survey has begun and will obtain high quality spectroscopy of some 100000 Milky Way stars, in the field and in open clusters, down to magnitude 19, systematically covering all the major components of the Milky Way. This survey will provide the first homogeneous o...

  9. L'ESO au temps du CERN

    CERN Multimedia

    Schaeffer, A

    2012-01-01

    L’Observatoire européen austral (ESO) fête aujourd’hui ses 50 ans. Retour sur l’histoire d’un des plus grands laboratoires européens, qui fut soutenu et accompagné par le CERN dès ses premières heures.

  10. ESO Helps Antofagasta Region after the Earthquake

    Science.gov (United States)

    2007-11-01

    On November 14 at 12:41 local time, a major earthquake with magnitude 7.7 on the Richter scale affected the north of Chile. The epicentre was located 35 km from the city of Tocopilla and 170 km of Antofagasta. Two persons died and tens were injured, while buildings were damaged in several cities. In the Maria Elena-Tocopilla area, several thousand homes were destroyed or damaged. In an act of solidarity with the local community and its authorities, ESO immediately announced a donation of 30 millions Chilean pesos (around 40,000 euros) to Antofagasta's Regional Government to support reconstruction in the Region II. ESO and its staff have been shocked by the earthquake and its impact on local communities, especially on the people of Tocopilla. The ESO Representation in Chile formally contacted the regional authorities to explore with them possible ways to collaborate in this difficult moment. In addition, many of ESO staff are personally cooperating with the victims, under the coordination of Cruz Roja, the organisation currently in charge of implementing individual efforts.

  11. Tragic Car Accident Involves ESO Employees

    Science.gov (United States)

    2000-06-01

    Saturday, May 27, turned into a tragic day for ESO. The team installing TIMMI2 at La Silla, went on an excursion to the Elqui valley, 70 km east of the city of La Serena and suffered a serious car accident, crashing against another car driving from the opposite direction.

  12. The Gaia-ESO Public Spectroscopic Survey

    DEFF Research Database (Denmark)

    Gilmore, G.; Randich, S.; Asplund, M.;

    2012-01-01

    The Gaia-ESO Public Spectroscopic Survey has begun and will obtain high quality spectroscopy of some 100000 Milky Way stars, in the field and in open clusters, down to magnitude 19, systematically covering all the major components of the Milky Way. This survey will provide the first homogeneous o...

  13. X-ray Emission from Young Stars in the TW Hya Association

    CERN Document Server

    Brown, Alexander; Ayres, Thomas R; France, Kevin; Brown, Joanna M

    2014-01-01

    The 9 Myr old TW Hya Association (TWA) is the nearest group (typical distances of $\\sim$50 pc) of pre-main-sequence (PMS) stars with ages less than 10 Myr and contains stars with both actively accreting disks and debris disks. We have studied the coronal X-ray emission from a group of low mass TWA common proper motion binaries using the {\\it{Chandra}} and {\\it{Swift}} satellites. Our aim is to understand better their coronal properties and how high energy photons affect the conditions around young stars and their role in photo-exciting atoms, molecules and dust grains in circumstellar disks and lower density circumstellar gas. Once planet formation is underway, this emission influences protoplanetary evolution and the atmospheric conditions of the newly-formed planets. The X-ray properties for 7 individual stars (TWA 13A, TWA 13B, TWA 9A, TWA 9B, TWA 8A, TWA 8B, and TWA 7) and 2 combined binary systems (TWA 3AB and TWA 2AB) have been measured. All the stars with sufficient signal require two-component fits to...

  14. DI Hya: A Near-contact Binary with a Close-in Companion

    Science.gov (United States)

    Liao, W.-P.; Qian, S.-B.; Li, L.-J.; Zhou, X.; Zhao, E.-G.; Zhang, J.

    2017-03-01

    DI Hya is a short-period eclipsing binary and its classification has been discussed by several authors. New four-color light curves were obtained and have been analyzed together with the data from Manimanis & Niarchos simultaneously using the W–D method. The binary turns out to be a near-contact system where both components are filling or nearly filling their critical Roche lobes. The secondary has a temperature difference of ΔT ≃ ‑2800 K. The orbital period investigation has been ignored so far. All charge-coupled devices (CCD) and pe times of light minima are used for period analysis, showing that a cyclic variation with a short period of 1.46 years and a small semi-amplitude of 0.0034 days and a downward parabolic variation with a rate of \\dot{P}=-2.98(+/- 0.32)× {10}-7 {days} {{yr}}-1. The short period and small semi-amplitude cyclic variations were analyzed for the light-travel time effect via the presence of a close-in tertiary binary with an orbital separation shorter than 1.57(±0.31) au. Orbital properties of this close-in companion should provide valuable information on the formation of this short-period binary and stellar dynamical interaction. The downward parabolic change may be caused by angular momentum loss via an enhanced stellar wind of the more evolved secondary star.

  15. Volatile carbon locking and release in protoplanetary disks. A study of TW Hya and HD 100546

    CERN Document Server

    Kama, M; van Dishoeck, E F; Hogerheijde, M; Folsom, C P; Miotello, A; Fedele, D; Belloche, A; Güsten, R; Wyrowski, F

    2016-01-01

    The composition of planetary solids and gases is largely rooted in the processing of volatile elements in protoplanetary disks. To shed light on the key processes, we carry out a comparative analysis of the gas-phase carbon abundance in two systems with a similar age and disk mass, but different central stars: HD 100546 and TW Hya. We combine our recent detections of C$^{0}$ in these disks with observations of other carbon reservoirs (CO, C$^{+}$, C$_{2}$H) and gas mass and warm gas tracers (HD, O$^{0}$), as well as spatially resolved ALMA observations and the spectral energy distribution. The disks are modelled with the DALI 2D physical-chemical code. Stellar abundances for HD 100546 are derived from archival spectra. Upper limits on HD emission from HD 100546 place an upper limit on the total disk mass of $\\leq0.1\\,M_{\\odot}$. The gas-phase carbon abundance in the atmosphere of this warm Herbig disk is at most moderately depleted compared to the interstellar medium, with [C]/[H]$_{\\rm gas}=(0.1-1.5)\\times 1...

  16. New Parallaxes and a Convergence Analysis for the TW Hya Association

    CERN Document Server

    Donaldson, Jessica K; Gagné, Jonathan; Faherty, Jacqueline K; Boss, Alan P; Keiser, Sandra A

    2016-01-01

    The TW Hya Association (TWA) is a nearby stellar association with an age of $\\sim$ 5-10 Myr. This is an important age for studying the late stages of star and planet formation. We measure the parallaxes of 14 candidate members of TWA. That brings to 38 the total number of individual stars with fully measured kinematics, i.e. proper motion, radial velocity, and parallax, to describe their motions through the Galaxy. We analyze these kinematics to search for convergence to a smaller volume in the past, but we find the association is never much more compact than it is at present. We show that it is difficult to measure traceback ages for associations such as TWA that have expected velocity dispersions of 1-2 km s$^{-1}$ with typical measurement uncertainties. We also use our stellar distances and pre-main-sequence evolutionary tracks to find the average age of the association of 7.9 $\\pm$ 1.0 Myr. Additionally, our parallax measurement of TWA 32 indicates it should be considered a bona fide member of TWA. Two ne...

  17. M Stars in the TW Hya Association: Stellar X-rays and Disk Dissipation

    CERN Document Server

    Kastner, Joel H; Punzi, Kristina; Stelzer, Beate; Gorti, Uma; Pascucci, Ilaria; Argiroffi, Costanza

    2016-01-01

    To investigate the potential connection between the intense X-ray emission from young, low-mass stars and the lifetimes of their circumstellar, planet-forming disks, we have compiled the X-ray luminosities ($L_X$) of M stars in the $\\sim$8 Myr-old TW Hya Association (TWA) for which X-ray data are presently available. Our investigation includes analysis of archival Chandra data for the TWA binary systems TWA 8, 9, and 13. Although our study suffers from poor statistics for stars later than M3, we find a trend of decreasing $L_X/L_{bol}$ with decreasing $T_{eff}$ for TWA M stars wherein the earliest-type (M0--M2) stars cluster near $\\log{(L_X/L_{bol})} \\approx -3.0$ and then $\\log{(L_X/L_{bol})}$ decreases, and its distribution broadens, for types M4 and later. The fraction of TWA stars that display evidence for residual primordial disk material also sharply increases in this same (mid-M) spectral type regime. This apparent anticorrelation between the relative X-ray luminosities of low-mass TWA stars and the lo...

  18. Constraining Accretion Signatures of Exoplanets in the TW Hya Transitional Disk

    Science.gov (United States)

    Uyama, Taichi; Tanigawa, Takayuki; Hashimoto, Jun; Tamura, Motohide; Aoyama, Yuhiko; Brandt, Timothy D.; Ishizuka, Masato

    2017-09-01

    We present a near-infrared direct imaging search for accretion signatures of possible protoplanets around the young stellar object (YSO) TW Hya, a multi-ring disk exhibiting evidence of planet formation. The Paβ line (1.282 μm) is an indication of accretion onto a protoplanet, and its intensity is much higher than that of blackbody radiation from the protoplanet. We focused on the Paβ line and performed Keck/OSIRIS spectroscopic observations. Although spectral differential imaging (SDI) reduction detected no accretion signatures, the results of the present study allowed us to set 5σ detection limits for Paβ emission of 5.8 × 10-18 and 1.5 × 10-18 erg-1 s-1 cm-2 at 0.″4 and 1.″6, respectively. We considered the mass of potential planets using theoretical simulations of circumplanetary disks and hydrogen emission. The resulting masses were 1.45 ± 0.04 M J and {2.29}-0.04+0.03 {M}{{J}} at 25 and 95 au, respectively, which agree with the detection limits obtained from previous broadband imaging. The detection limits should allow for the identification of protoplanets as small as ˜1 M J, which may assist in direct imaging searches around faint YSOs for which extreme adaptive optics instruments are unavailable.

  19. High spatial resolution mid-infrared observations of the low-mass young star TW Hya

    CERN Document Server

    Ratzka, T; Henning, T; Bouwman, J; Dullemond, C P; Jaffe, W

    2007-01-01

    We want to improve knowledge of the structure of the inner few AU of the circumstellar disk around the nearby T Tauri star TW Hya. Earlier studies have suggested the existence of a large inner hole, possibly caused by interactions with a growing protoplanet. We used interferometric observations in the N-band obtained with the MIDI instrument on the Very Large Telescope Interferometer, together with 10 micron spectra recorded by the infrared satellite Spitzer. The fact that we were able to determine N-band correlated fluxes and visibilities for this comparatively faint source shows that MIR interferometry can be applied to a large number of low-mass young stellar objects. The MIR spectra obtained with Spitzer reveal emission lines from HI (6-5), HI (7-6), and [Ne II] and show that over 90% of the dust we see in this wavelength regime is amorphous. According to the correlated flux measured with MIDI, most of the crystalline material is in the inner, unresolved part of the disk, about 1 AU in radius. The visibil...

  20. Evidence for a Snow Line Beyond the Transitional Radius in the TW Hya Protoplanetary Disk

    CERN Document Server

    Zhang, K; Salyk, C; Blake, G A

    2013-01-01

    We present an observational reconstruction of the radial water vapor content near the surface of the TW Hya transitional protoplanetary disk, and report the first localization of the snow line during this phase of disk evolution. The observations are comprised of Spitzer-IRS, Herschel-PACS, and Herschel-HIFI archival spectra. The abundance structure is retrieved by fitting a two-dimensional disk model to the available star+disk photometry and all observed H2O lines, using a simple step-function parameterization of the water vapor content near the disk surface. We find that water vapor is abundant (~10^{-4} per H2) in a narrow ring, located at the disk transition radius some 4AU from the central star, but drops rapidly by several orders of magnitude beyond 4.2 AU over a scale length of no more than 0.5AU. The inner disk (0.5-4AU) is also dry, with an upper limit on the vertically averaged water abundance of 10^{-6} per H2. The water vapor peak occurs at a radius significantly more distant than that expected fo...

  1. Professor Tim de Zeeuw Takes Up Duty as New ESO Director General

    Science.gov (United States)

    2007-09-01

    On 1 September, Tim de Zeeuw became the new ESO Director General, succeeding Catherine Cesarsky. In his first day in office, he kindly agreed to answer a few questions. ESO PR Photo 38/07 ESO PR Video 38/07 Watch the Video! How would you describe the current period for astronomy? Tim de Zeeuw: We are in an extremely exciting time for astronomy and I think this is understood worldwide and not just by astronomers. The technology is now available to look not only at the farthest objects in the Universe, where the light left a long time ago, allowing us to see how the Universe evolved and developed, but we can even detect signatures of planets around other stars, and that answers an age-old question which is a fundamental question in all of science, and really excites the general public. How do you see the role of ESO in this context? Tim de Zeeuw: ESO has a very important role in the context of European and worldwide astronomy because it is one of the leading organisations for ground-based astronomy. You may even say it is the pre-eminent organisation. Therefore, we have both an opportunity and a responsibility to lead the further developments in astronomy. Where do you see ESO developing in the coming years? Tim de Zeeuw: I see three main goals for ESO in the coming years. The first one is to get the best possible science out of the Very Large Telescope, the interferometer and the survey telescopes, all of them on Paranal. The second is to build ALMA, the new observatory at 5 000 metres in the high Andes. Together with our North American and East Asian partners, we need to deliver this on budget and on time, and prepare the European astronomers for leading the science. The third main goal is to design a world-leading Extremely Large Telescope (ELT), which may have a main mirror with a diameter larger than 40 metres and will enable wonderful science. And of course, we don't only want to design it, we also want to construct it. And what about La Silla? Tim de Zeeuw: La

  2. NY-ESO-1 expression in DCIS: A new predictor of good prognosis.

    Science.gov (United States)

    Coombes, R Charles; Caballero, Otavia L; Shousha, Sami; Ghaem-Maghami, Sadaf; Woodley-Barker, Laura; Wilhelm-Benartzi, Charlotte S; Neville, A Munro

    2017-03-01

    At present, it is difficult to predict which patients with ductal carcinoma-in-situ (DCIS) will subsequently develop frank invasive breast cancer (IDC). A recent survey by our group has shown that NY-ESO-1 and MAGEA are both expressed in DCIS. This study was aimed at determining whether expression of these antigens was related to the later development of IDC. 14 of 42 (33%) of patients developed invasive breast cancer during the follow up period. Only one of those DCIS cases that relapsed was positive for NYESO-1 at diagnosis. In contrast, DCIS samples of 15 of the 28 (54%) of those patients who remained disease-free expressed NY-ESO-1. (Permutation chi square p=0.0033). We identified 42 patients with DCIS, and followed them up for more than 10 years. NY-ESO-1 and MAGEA were demonstrated by immunostaining as were CD8+ infiltrates on all sections together with the conventional markers, ER, PR, and HER2. Expression of NY-ESO-1 may predict those patients who will not subsequently develop invasive breast cancer and could therefore potentially be helpful in defining prognosis in patients with DCIS.

  3. Deformable mirrors development program at ESO

    Science.gov (United States)

    Stroebele, Stefan; Vernet, Elise; Brinkmann, Martin; Jakob, Gerd; Lilley, Paul; Casali, Mark; Madec, Pierre-Yves; Kasper, Markus

    2016-07-01

    Over the last decade, adaptive optics has become essential in different fields of research including medicine and industrial applications. With this new need, the market of deformable mirrors has expanded a lot allowing new technologies and actuation principles to be developed. Several E-ELT instruments have identified the need for post focal deformable mirrors but with the increasing size of the telescopes the requirements on the deformable mirrors become more demanding. A simple scaling up of existing technologies from few hundred actuators to thousands of actuators will not be sufficient to satisfy the future needs of ESO. To bridge the gap between available deformable mirrors and the future needs for the E-ELT, ESO started a development program for deformable mirror technologies. The requirements and the path to get the deformable mirrors for post focal adaptive optics systems for the E-ELT is presented.

  4. El operador discursivo ya si eso

    Directory of Open Access Journals (Sweden)

    Elvira Comas Leonés

    2015-12-01

    Full Text Available La pragmática es una ciencia en constante evolución y actualidad, tanto como el estudio del español coloquial, que, en nuestros días, supone enfocar la lengua a estructuras muy utilizadas por los hablantes pero que no poseen análisis exhaustivos por parte de la lingüística. En este uso mayoritariamente oral de la lengua, podemos encontrar determinados marcadores que los hablantes a menudo utilizan y que podemos considerar objetos de estudio. Los operadores discursivos si eso y sus variantes, como ya si eso, son construcciones que aún no se han lexicalizado pero que merecen ser objeto de estudio por cuanto su uso y connotaciones están aumentando en la actualidad. 

  5. Characterization and analysis of a transcriptome from the boreal spider crab Hyas araneus.

    Science.gov (United States)

    Harms, Lars; Frickenhaus, Stephan; Schiffer, Melanie; Mark, Felix C; Storch, Daniela; Pörtner, Hans-Otto; Held, Christoph; Lucassen, Magnus

    2013-12-01

    Research investigating the genetic basis of physiological responses has significantly broadened our understanding of the mechanisms underlying organismic response to environmental change. However, genomic data are currently available for few taxa only, thus excluding physiological model species from this approach. In this study we report the transcriptome of the model organism Hyas araneus from Spitsbergen (Arctic). We generated 20,479 transcripts, using the 454 GS FLX sequencing technology in combination with an Illumina HiSeq sequencing approach. Annotation by Blastx revealed 7159 blast hits in the NCBI non-redundant protein database. The comparison between the spider crab H. araneus transcriptome and EST libraries of the European lobster Homarus americanus and the porcelain crab Petrolisthes cinctipes yielded 3229/2581 sequences with a significant hit, respectively. The clustering by the Markov Clustering Algorithm (MCL) revealed a common core of 1710 clusters present in all three species and 5903 unique clusters for H. araneus. The combined sequencing approaches generated transcripts that will greatly expand the limited genomic data available for crustaceans. We introduce the MCL clustering for transcriptome comparisons as a simple approach to estimate similarities between transcriptomic libraries of different size and quality and to analyze homologies within the selected group of species. In particular, we identified a large variety of reverse transcriptase (RT) sequences not only in the H. araneus transcriptome and other decapod crustaceans, but also sea urchin, supporting the hypothesis of a heritable, anti-viral immunity and the proposed viral fragment integration by host-derived RTs in marine invertebrates. © 2013.

  6. Chasing Shadows: Rotation of the Azimuthal Asymmetry in the TW Hya Disk

    Science.gov (United States)

    Debes, John H.; Poteet, Charles A.; Jang-Condell, Hannah; Gaspar, Andras; Hines, Dean; Kastner, Joel H.; Pueyo, Laurent; Rapson, Valerie; Roberge, Aki; Schneider, Glenn; Weinberger, Alycia J.

    2017-02-01

    We have obtained new images of the protoplanetary disk orbiting TW Hya in visible, total intensity light with the Space Telescope Imaging Spectrograph (STIS) on the Hubble Space Telescope (HST), using the newly commissioned BAR5 occulter. These HST/STIS observations achieved an inner working angle of ∼0.″2, or 11.7 au, probing the system at angular radii coincident with recent images of the disk obtained by ALMA and in polarized intensity near-infrared light. By comparing our new STIS images to those taken with STIS in 2000 and with NICMOS in 1998, 2004, and 2005, we demonstrate that TW Hya’s azimuthal surface brightness asymmetry moves coherently in position angle. Between 50 au and 141 au we measure a constant angular velocity in the azimuthal brightness asymmetry of 22.°7 yr‑1 in a counterclockwise direction, equivalent to a period of 15.9 yr assuming circular motion. Both the (short) inferred period and lack of radial dependence of the moving shadow pattern are inconsistent with Keplerian rotation at these disk radii. We hypothesize that the asymmetry arises from the fact that the disk interior to 1 au is inclined and precessing owing to a planetary companion, thus partially shadowing the outer disk. Further monitoring of this and other shadows on protoplanetary disks potentially opens a new avenue for indirectly observing the sites of planet formation. Based on observations made with the NASA/ESA Hubble Space Telescope, obtained from the data archive at the Space Telescope Science Institute. STScI is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS 5-26555.

  7. X-ray Emission from Young Stars in the TW Hya Association

    Science.gov (United States)

    Brown, Alexander; Herczeg, Gregory J.; Ayres, Thomas R.; France, Kevin; Brown, Joanna M.

    2015-01-01

    The 9 Myr old TW Hya Association (TWA) is the nearest group (typical distances of ˜50 pc) of pre-main-sequence (PMS) stars with ages less than 10 Myr and contains stars with both actively accreting disks and debris disks. We have studied the coronal X-ray emission from a group of low mass TWA common proper motion binaries using the Chandra and Swift satellites. Our aim is to understand better their coronal properties and how high energy photons affect the conditions around young stars and their role in photo-exciting atoms, molecules and dust grains in circumstellar disks and lower density circumstellar gas. Once planet formation is underway, this emission influences protoplanetary evolution and the atmospheric conditions of the newly-formed planets. The X-ray properties for 7 individual stars (TWA 13A, TWA 13B, TWA 9A, TWA 9B, TWA 8A, TWA 8B, and TWA 7) and 2 combined binary systems (TWA 3AB and TWA 2AB) have been measured. All the stars with sufficient signal require two-component fits to their CCD-resolution X-ray spectra, typically with a dominant hot (~2 kev (25 MK)) component and a cooler component at ~0.4 keV (4 MK). The brighter sources all show significant X-ray variability (at a level of 50-100% of quiescence) over the course of 5-15 ksec observations due to flares. We present the X-ray properties for each of the stars and find that the coronal emission is in the super-saturated rotational domain.

  8. ESO's Telescopes In memoriam Daniel Enard

    Science.gov (United States)

    Gilmozzi, Roberto

    2009-06-01

    The contributions of ESO to the art of telescope-making have come a long way since the early years, placing it, by the turn of the millennium, among the acknowledged leaders in the field. In this article I will give a brief history of what are, in my view, the highlights among these developments, from the 3.6-metre telescope through the NTT and VLT/I to the E-ELT.

  9. ESO VLT laser guide star facility

    Science.gov (United States)

    Bonaccini, Domenico; Hackenberg, Wolfgang K.; Cullum, Martin J.; Brunetto, Enzo; Ott, Thomas; Quattri, Marco; Allaert, Eric; Dimmler, Martin; Tarenghi, Massimo; Van Kersteren, A.; Di Chirico, C.; Buzzoni, Bernard; Gray, Peter; Tamai, R.; Tapia, M.

    2002-02-01

    We report in this paper on the design and progress of the ESO Laser Guide Star Facility. The project will create a user facility embedded in UT4, to produce in the Earth's Mesosphere Laser Guide Stars, which extend the sky coverage of Adaptive Optics systems on the VLT UT4 telescope. Embedded into the project are provisions for multiple LGS to cope with second generation MCAO instruments.

  10. On the area of accretion curtains from fast aperiodic time variability of the intermediate polar EX Hya

    CERN Document Server

    Semena, Andrey N; Buckley, David A H; Kotze, Marissa M; Khabibullin, Ildar I; Breytenbach, Hannes; Gulbis, Amanda A S; Coppejans, Rocco; Potter, Stephen B

    2014-01-01

    We present results of a study of the fast timing variability of the magnetic cataclysmic variable (mCV) EX Hya. It was previously shown that one may expect the rapid flux variability of mCVs to be smeared out at timescales shorter than the cooling time of hot plasma in the post shock region of the accretion curtain near the WD surface. Estimates of the cooling time and the mass accretion rate, thus provide us with a tool to measure the density of the post-shock plasma and the cross-sectional area of the accretion funnel at the WD surface. We have probed the high frequencies in the aperiodic noise of one of the brightest mCV EX Hya with the help of optical telescopes, namely SALT and the SAAO 1.9m telescope. We place upper limits on the plasma cooling timescale $\\tau<$0.3 sec, on the fractional area of the accretion curtain footprint $f<1.6\\times10^{-4}$, and a lower limit on the specific mass accretion rate $\\dot{M}/A \\gtrsim $3 g/sec/cm$^{-2}$. We show that measurements of accretion column footprints v...

  11. UVES and X-Shooter spectroscopy of the emission line AM CVn systems GP Com and V396 Hya

    CERN Document Server

    Kupfer, T; Groot, P J; Marsh, T R; Nelemans, G; Roelofs, G H A

    2016-01-01

    We present time-resolved spectroscopy of the AM CVn-type binaries GP Com and V396 Hya obtained with VLT/X-Shooter and VLT/UVES. We fully resolve the narrow central components of the dominant helium lines and determine radial velocity semi-amplitudes of $K_{\\rm spike} = 11.7\\pm0.3$ km s$^{-1}$ for GP Com and $K_{\\rm spike} = 5.8\\pm0.3$ km s$^{-1}$ for V396 Hya. The mean velocities of the narrow central components show variations from line to line. Compared to calculated line profiles that include Stark broadening we are able to explain the displacements, and the appearance of forbidden helium lines, by additional Stark broadening of emission in a helium plasma with an electron density $n_e\\simeq 5\\times 10^{15}$ cm$^{-3}$. More than $30$ nitrogen and more than $10$ neon lines emission lines were detected in both systems. Additionally, $20$ nitrogen absorption lines are only seen in GP Com. The radial velocity variations of these lines show the same phase and velocity amplitude as the central helium emission co...

  12. Dusty wind of W Hya. Multi-wavelength modelling of the present-day and recent mass-loss

    CERN Document Server

    Khouri, T; de Koter, A; Decin, L; Min, M; de Vries, B L; Lombaert, R; Cox, N L J

    2015-01-01

    Low- and intermediate-mass stars go through a period of intense mass-loss at the end of their lives in a phase known as the asymptotic giant branch (AGB). During the AGB a significant fraction of their initial mass is expelled in a stellar wind. This process controls the final stages of their evolution and contributes to the chemical evolution of galaxies. However, the wind-driving mechanism of AGB stars is not yet well understood, especially so for oxygen-rich sources. Characterizing both the present-day mass-loss and wind structure and the evolution of the mass-loss rate of such stars is paramount to advancing our understanding of this processes. We modelled the dust envelope of W Hya using an advanced radiative transfer code. The dust model was analysed in the light of a previously calculated gas-phase wind model and compared to measurements available in the literature, such as infrared spectra, infrared images, and optical scattered light fractions. We find that the dust spectrum of W Hya can partly be ex...

  13. The Radial Distribution of H2 and CO in TW Hya as Revealed by Resolved ALMA Observations of CO Isotopologues

    CERN Document Server

    Schwarz, Kamber R; Cleeves, L Ilsedore; Blake, Geoffrey A; Zhang, Ke; Öberg, Karin I; van Dishoeck, Ewine F; Qi, Chunhua

    2016-01-01

    CO is widely used as a tracer of molecular gas. However, there is now mounting evidence that gas phase carbon is depleted in the disk around TW Hya. Previous efforts to quantify this depletion have been hampered by uncertainties regarding the radial thermal structure in the disk. Here we present resolved ALMA observations of 13CO 3-2, C18O 3-2, 13CO 6-5, and C18O 6-5 emission in TW Hya, which allow us to derive radial gas temperature and gas surface density profiles, as well as map the CO abundance as a function of radius. These observations provide a measurement of the surface CO snowline at ~30 AU and show evidence for an outer ring of CO emission centered at 53 AU, a feature previously seen only in less abundant species. Further, the derived CO gas temperature profile constrains the freeze-out temperature of CO in the warm molecular layer to < 21 K. Combined with the previous detection of HD 1-0, these data constrain the surface density of the warm H2 gas in the inner ~30 AU. We find that CO is depleted...

  14. ESO Receives Computerworld Honors Program 21st Century Achievement Award in Science Category

    Science.gov (United States)

    2005-06-01

    In a ceremony held in Washington, D.C. (USA) on June 6, 2005, ESO, the European Organisation for Astronomical Research in the southern Hemisphere, received the coveted 21st Century Achievement Award from the Computerworld Honors Program for its visionary use of information technology in the Science category. Sybase, a main database server vendor and member of the Chairmen's Committee, nominated ESO's Data Flow System in recognition of its contributions to the global information technology revolution and its positive impact on society. The citations reads: "ESO has revolutionized the operations of ground-based astronomical observatories with a new end-to-end data flow system, designed to improve the transmission and management of astronomical observations and data over transcontinental distances." This year's awards, in 10 categories, were presented at a gala event at the National Building Museum, attended by over 250 guests, including leaders of the information technology industry, former award recipients, judges, scholars, and diplomats representing many of the 54 countries from which the 17-year-old program's laureates have come. "The Computerworld Honors Program 21st Century Achievement Awards are presented to companies from around the world whose visionary use of information technology promotes positive social, economic and educational change," said Bob Carrigan, president and CEO of Computerworld and chairman of the Chairmen's Committee of the Computerworld Honors Program. "The recipients of these awards are the true heroes of the information age and have been appropriately recognized by the leading IT industry chairmen as true revolutionaries in their fields." ESO PR Photo 18/05 ESO PR Photo 18/05 ESO Receives the Award in the Science Category [Preview - JPEG: 400 x 496 pix - 53k] [Normal - JPEG: 800 x 992 pix - 470k] [Full Res - JPEG: 1250 x 1550 pix - 1.1M] Caption: ESO PR Photo 18/05: Receiving the Computerworld 21st Century Achievement Award for Science

  15. The AstroMundus-ESO Connection

    Science.gov (United States)

    Humphreys, E.; Hussain, G.; Biggs, A.; Lu, H.-Y.; Emsellem, E.; De Cia, A.; Lavail, A.; Spyromilio, J.

    2016-03-01

    The AstroMundus Programme is an E+ Erasmus Mundus Joint Masters Degree course in astronomy and astrophysics offered by a consortium of European universities and research institutes. In 2014 and 2016, AstroMundus Masters students visited ESO and participated in proposal-writing sessions, during which groups of students speed-wrote complete ALMA proposals, before presenting them to a pseudo Time Allocation Committee providing on-the-spot feedback. The AstroMundus visit of 25-26 January 2016 is described.

  16. The ESO Large Programme First Stars

    CERN Document Server

    Bonifacio, P; Andrievsky, S; Barbuy, B; Beers, T C; Caffau, E; Cayrel, R; Depagne, E; François, P; Hernandez, J I Gonzalez; Hansen, C J; Herwig, F; Hill, V; Korotin, S A; Ludwig, H -G; Molaro, P; Nordström, B; Plez, B; Primas, F; Sivarani, T; Spite, F; Spite, M

    2008-01-01

    In ESO period 65 (April-September 2000) the large programme 165.N-0276, led by Roger Cayrel, began making use of UVES at the Kueyen VLT telescope. Known within the Team and outside as ``First Stars'', it was aimed at obtaining high resolution, high signal-to-noise ratio spectra in the range 320 nm -- 1000 nm for a large sample of extremely metal-poor (EMP) stars identified from the HK objective prism survey.In this contribution we highlight the main results of the large programme.

  17. Validation of ESO Phase 3 data submissions

    Science.gov (United States)

    Delmotte, N.; Arnaboldi, M.; Mascetti, L.; Micol, A.; Retzlaff, J.

    2016-07-01

    The data validation phase is an essential step of the Phase 3 process at ESO that is defining and providing an infrastructure to deal with interactions between the data producers and the archive. We are using a controlled process to systematically review all Phase 3 data submissions to ensure a homogeneous and consistent science archive with well traceable and characterised data products, to the benefits of archive users. How the Phase 3 data validation plan is defined and how its results are subsequently managed will be described in the presentation. For a description of its technical implementation, please refer to the contribution by L. Mascetti.

  18. The ESO-LV project - Automated parameter extraction for 16000 ESO/Uppsala galaxies

    NARCIS (Netherlands)

    Lauberts, Andris; Valentijn, Edwin A.

    1987-01-01

    A program to extract photometric and morphological parameters of the galaxies in the ESO/Uppsala survey (Lauberts and Valentijn, 1982) is discussed. The completeness and accuracy of the survey are evaluated and compared with other surveys. The parameters obtained in the program are listed.

  19. The ESO-LV project - Automated parameter extraction for 16000 ESO/Uppsala galaxies

    NARCIS (Netherlands)

    Lauberts, Andris; Valentijn, Edwin A.

    1987-01-01

    A program to extract photometric and morphological parameters of the galaxies in the ESO/Uppsala survey (Lauberts and Valentijn, 1982) is discussed. The completeness and accuracy of the survey are evaluated and compared with other surveys. The parameters obtained in the program are listed.

  20. First Kepler results on compact pulsators - II. KIC 010139564, a new pulsating subdwarf B (V361 Hya) star with an additional low-frequency mode

    DEFF Research Database (Denmark)

    Kawaler, Stephen; Reed, M.D.; Quint, A.C.;

    2010-01-01

    We present the discovery of non-radial pulsations in a hot subdwarf B star based on 30.5 d of nearly continuous time series photometry using the Kepler spacecraft. KIC 010139564 is found to be a short-period pulsator of the V361 Hya (EC 14026) class with more than 10 independent pulsation modes...

  1. VLT instrumentation control: the collaboration of OATs with ESO

    Science.gov (United States)

    Santin, P.

    The collaboration of the Astrophysics Technology Group (ATG) of the Astronomical Observatory of Trieste with ESO will be presented. It may be considered as an example of a good practice in the collaboration of a peripheral Institute with ESO. Started in 1985, it spans almost all the time since Italy joined ESO in 1982. The Trieste Astrophysics Technology Group (ATG) participated in many technological enterprise of ESO, from Remote Observing to VLT instrumentation and to ALMA ACS, and is now looking for the challenging E-ELT.

  2. ESO science data product standard for 1D spectral products

    Science.gov (United States)

    Micol, Alberto; Arnaboldi, Magda; Delmotte, Nausicaa A. R.; Mascetti, Laura; Retzlaff, Joerg

    2016-07-01

    The ESO Phase 3 process allows the upload, validation, storage, and publication of reduced data through the ESO Science Archive Facility. Since its introduction, 2 million data products have been archived and published; 80% of them are one-dimensional extracted and calibrated spectra. Central to Phase3 is the ESO science data product standard that defines metadata and data format of any product. This contribution describes the ESO data standard for 1d-spectra, its adoption by the reduction pipelines of selected instrument modes for in-house generation of reduced spectra, the enhanced archive legacy value. Archive usage statistics are provided.

  3. Europe's Astronomy Teachers Meet at ESO

    Science.gov (United States)

    1994-12-01

    European Association for Astronomy Education Formed A joint EU/ESO Workshop (1) on the Teaching of Astronomy in Europe was held at the ESO Headquarters from November 25-30, 1994, under the auspices of the 1994 European Week for Scientific Culture. More than 100 teachers from secondary schools in 17 European countries participated together with representatives of national ministries and local authorities, as well as professional astronomers. This meeting was the first of its kind ever held and was very successful. As a most visible and immediate outcome, the participants agreed to form the "European Association for Astronomy Education (EAAE)", uniting astronomy educators all over Europe into one network. A provisional Executive Committee of the EAAE was elected which will work towards the organisation of a constitutional conference within the next year. The participants unanimously adopted a "Declaration on the Teaching of Astronomy in Europe", specifying the overall aims and initial actions needed to achieve them. Astronomy: Science, Technology and Culture At the beginning of the Workshop the participants listened to lectures by several specialists about some of the most active fields of astronomy. The scientific sessions included topics as diverse as minor bodies in the solar system, nucleosynthesis, interstellar chemistry and cosmology. Then followed overviews of various recent advances in astronomical technology, some of which are already having direct impact on highly specialized sectors of European industry. They included the advanced use of computers in astronomy, for instance within image processing and data archiving, as well as a demonstration of remote observing. Discussing the cultural aspects, Nigel Calder (UK) and Hubert Reeves (France) emphasized the important role of astronomy in modern society, in particular its continuing influence on our perceptions of mankind's unique location in time and space. Teaching of Astronomy in European Countries

  4. TECNICAS DE ESTUDIO: ADQUISICIÓN Y APLICACIÓN EN LA ESO

    OpenAIRE

    Sanz-Hernández, Itzíar

    2012-01-01

    El presente trabajo, realizado con una muestra de 124 alumnos de secundaria, pretende investigar cómo adquieren estos alumnos las técnicas de estudio y cuál es la aplicación práctica de las mismas, además de analizar sus hábitos de estudio. Se considera que estos factores influyen a la hora de adquirir aprendizajes significativos y que están relacionados con las diferencias de rendimiento escolar, existentes entre los alumnos de ESO. Los resultados muestran que los alumnos que pue...

  5. Structure and Dynamics of the Accretion Process and Wind in TW Hya

    Science.gov (United States)

    Dupree, A. K.; Brickhouse, N. S.; Cranmer, S. R.; Berlind, P.; Strader, Jay; Smith, Graeme H.

    2014-07-01

    Time-domain spectroscopy of the classical accreting T Tauri star, TW Hya, covering a decade and spanning the far UV to the near-infrared spectral regions can identify the radiation sources, the atmospheric structure produced by accretion, and properties of the stellar wind. On timescales from days to years, substantial changes occur in emission line profiles and line strengths. Our extensive time-domain spectroscopy suggests that the broad near-IR, optical, and far-uv emission lines, centered on the star, originate in a turbulent post-shock region and can undergo scattering by the overlying stellar wind as well as some absorption from infalling material. Stable absorption features appear in Hα, apparently caused by an accreting column silhouetted in the stellar wind. Inflow of material onto the star is revealed by the near-IR He I 10830 Å line, and its free-fall velocity correlates inversely with the strength of the post-shock emission, consistent with a dipole accretion model. However, the predictions of hydrogen line profiles based on accretion stream models are not well-matched by these observations. Evidence of an accelerating warm to hot stellar wind is shown by the near-IR He I line, and emission profiles of C II, C III, C IV, N V, and O VI. The outflow of material changes substantially in both speed and opacity in the yearly sampling of the near-IR He I line over a decade. Terminal outflow velocities that range from 200 km s-1 to almost 400 km s-1 in He I appear to be directly related to the amount of post-shock emission, giving evidence for an accretion-driven stellar wind. Calculations of the emission from realistic post-shock regions are needed. Data presented herein were obtained at the W. M. Keck Observatory, which is operated as a scientific partnership among the California Institute of Technology, the University of California, and the National Aeronautics and Space Administration. The Observatory was made possible by the generous financial support

  6. Materials didàctics per a la unitat d’electricitat de 2n d’ESO

    OpenAIRE

    Celades Pitarch, Lorena

    2012-01-01

    Els professors del centre on he realitzat el Pràcticum varen decidir no utilitzar cap llibre de Tecnologies per a 2n d’ESO, ja que no quadrava exactament amb les seves necessitats didàctiques. En aquest sentit, aquests professors han desenvolupat el seu propi material didàctic, encara que es tracta d’un desenvolupament inicial molt senzill. A través de l’experiència del Pràcticum, he observat que els professors i les professores del centre van desbordats de feina, i no tenen temps suficien...

  7. Report on the ESO Fellows Days in Chile 2011

    Science.gov (United States)

    West, M.; Emsellem, E.

    2012-03-01

    The 2011 ESO Fellows Days were held in Chile and brought together over 30 ESO Fellows from Garching and Chile. As well as presentations of research and social activities, the Fellows Days included a visit to San Pedro de Atacama and the ALMA site.

  8. Manufacturing of the ESO adaptive optics facility

    Science.gov (United States)

    Arsenault, R.,; Madec, P.-Y.; Hubin, N.; Stroebele, S.; Paufique, J.; Vernet, E.; Hackenberg, W.; Pirard, J.-F.; Jochum, L.; Glindemann, A.; Jost, A.; Conzelmann, R.; Kiekebusch, M.; Tordo, S.; Lizon, J.-L.; Donaldson, R.; Fedrigo, E.; Soenke, C.; Duchateau, M.; Bruton, A.; Delabre, B.; Downing, M.; Reyes, J.; Kolb, J.; Bechet, C.; Lelouarn, M.; Bonaccini Calia, D.; Quattri, M.; Guidolin, I.; Buzzoni, B.; Dupuy, C.; Guzman, R.; Comin, M.; Silber, A.; Quentin, J.; La Penna, P.; Manescau, A.; Jolley, P.; Heinz, V.; Duhoux, P.; Argomedo, J.; Gallieni, D.; Lazzarini, P.; Biasi, R.; Andrighettoni, M.; Angerer, G.; Pescoller, D.; Stuik, R.,; Deep, A.

    2010-07-01

    The ESO Adaptive Optics Facility (AOF) consists in an evolution of one of the ESO VLT unit telescopes to a laser driven adaptive telescope with a deformable mirror in its optical train, in this case the secondary 1.1m mirror, and four Laser Guide Stars (LGSs). This evolution implements many challenging technologies like the Deformable Secondary Mirror (DSM) including a thin shell mirror (1.1 m diameter and 2mm thin), the high power Na lasers (20W), the low Read-Out Noise (RON) WaveFront Sensor (WFS) camera (< 1e-) and SPARTA the new generation of Real Time Computers (RTC) for adaptive control. It also faces many problematic similar to any Extremely Large Telescope (ELT) and as such, will validate many technologies and solutions needed for the European ELT (E-ELT) 42m telescope. The AOF will offer a very large (7 arcmin) Field Of View (FOV) GLAO correction in J, H and K bands (GRAAL+Hawk-I), a visible integral field spectrograph with a 1 arcmin GLAO corrected FOV (GALACSI-MUSE WFM) and finally a LTAO 7.5" FOV (GALACSI-MUSE NFM). Most systems of the AOF have completed final design and are in manufacturing phase. Specific activities are linked to the modification of the 8m telescope in order to accommodate the new DSM and the 4 LGS Units assembled on its Center-Piece. A one year test period in Europe is planned to test and validate all modes and their performance followed by a commissioning phase in Paranal scheduled for 2014.

  9. Recent developments in evolutionary structural optimization (ESO) for continuum structures

    Science.gov (United States)

    Xie, Yi Min; Huang, Xiaodong

    2010-06-01

    Evolutionary Structural Optimization (ESO) and its later version bi-directional ESO (BESO) have gained widespread popularity among researchers in structural optimization and practitioners in engineering and architecture. However, there have also been many critical comments on various aspects of ESO/BESO. To address those criticisms, we have carried out extensive work to improve the original ESO/BESO algorithms in recent years. This paper summarizes some of the latest developments in the BESO method for topology optimization of continuum structures. Numerical results show that the ESO/BESO solutions agree well with those of other well-established topology optimization methods. It indicates that the current BESO method has great potential to become a robust and efficient design tool for practical applications in engineering and architecture.

  10. ESO and Fokker Space Sign Contract about VLTI Delay Line

    Science.gov (United States)

    1998-03-01

    The European Southern Observatory is building the world's largest optical telescope, the Very Large Telescope (VLT) , at the ESO Paranal Observatory in Chile. The VLT consists of four 8.2-m unit telescopes and several smaller, moveable Auxiliary Telescopes. When coupled as the giant VLT Interferometer (VLTI) , they will together provide the sharpest images ever obtained by any optical telescope. It will in principle be able to see an astronaut on the surface of the Moon, 400,000 km away. The VLTI Delay Lines Fokker Space (Leiden, The Netherlands) has been awarded a contract for the delivery of the Delay Line of the VLTI. This is a mechanical-optical system that will compensate the optical path differences of the light beams from the individual telescopes. Such a system is necessary to ensure that the light from all telescopes arrive in the same phase at the focal point of the interferometer. Otherwise, the very sharp interferometric images cannot be obtained. ESO PR Photo 08/98 [JPEG, 102k] Schematic representation of the VLTI Delay Line, showing the retro-reflector on its moving base. For more details, please consult the technical explanation below. This highly accurate system will be developed in close co-operation with the Dutch institute TNO-TPD (Netherlands Organization for Applied Scientific Research - Institute of Applied Physics) . The most innovative feature of the Delay Line is the new control strategy, a two-stage control system, based on linear motor technology, combined with high accuracy piezo-electric control elements. This enables the system to position the so-called cat's eye reflector system with an accuracy of only a few nanometers (millionth of a millimetre (nm)) over a stroke length of 60 metres. Within radio astronomy, interferometric techniques have been applied by Dutch astronomers since many years. They will now be able to contribute with their extensive knowledge of such systems to the next generation of astronomical interferometric

  11. ESO takes the public on an astronomical journey "Around the World in 80 Telescopes"

    Science.gov (United States)

    2009-03-01

    A live 24-hour free public video webcast, "Around the World in 80 Telescopes", will take place from 3 April 09:00 UT/GMT to 4 April 09:00 UT/GMT, chasing day and night around the globe to let viewers "visit" some of the most advanced astronomical telescopes on and off the planet. The webcast, organised by ESO for the International Year of Astronomy 2009 (IYA2009), is the first time that so many large observatories have been linked together for a public event. ESO PR Photo 13a/09 Map of Participating Observatories ESO PR Photo 13b/09 100 Hours of Astronomy logo Viewers will see new images of the cosmos, find out what observatories in their home countries or on the other side of the planet are discovering, send in questions and messages, and discover what astronomers are doing right now. Participating telescopes include those at observatories in Chile such as ESO's Very Large Telescope and La Silla, the Hawaii-based telescopes Gemini North and Keck, the Anglo-Australian Telescope, telescopes in the Canary Islands, the Southern African Large Telescope, space-based telescopes such as the NASA/ESA Hubble Space Telescope, ESA XMM-Newton and Integral, and many more. "Around the World in 80 Telescopes" will take viewers to every continent, including Antarctica! The webcast production will be hosted at ESO's headquarters near Munich, Germany, with live internet streaming by Ustream.tv. Anyone with a web browser supporting Adobe Flash will be able to follow the show, free of charge, from the website www.100hoursofastronomy.org and be a part of the project by sending messages and questions. The video player can be freely embedded on other websites. TV stations, web portals and science centres can also use the high quality feed. Representatives of the media who wish to report from the "front-line" and interview the team should get in touch. "Around the World in 80 Telescopes" is a major component of the 100 Hours of Astronomy (100HA), a Cornerstone project of the International

  12. NY-ESO-1 specific antibody and cellular responses in melanoma patients primed with NY-ESO-1 protein in ISCOMATRIX and boosted with recombinant NY-ESO-1 fowlpox virus.

    Science.gov (United States)

    Chen, Ji-Li; Dawoodji, Amina; Tarlton, Andrea; Gnjatic, Sacha; Tajar, Abdelouahid; Karydis, Ioannis; Browning, Judy; Pratap, Sarah; Verfaille, Christian; Venhaus, Ralph R; Pan, Linda; Altman, Douglas G; Cebon, Jonathan S; Old, Lloyd L; Nathan, Paul; Ottensmeier, Christian; Middleton, Mark; Cerundolo, Vincenzo

    2015-03-15

    Vaccination strategies based on repeated injections of NY-ESO-1 protein formulated in ISCOMATRIX particles (NY-ESO-1 ISCOMATRIX) have shown to elicit combined NY-ESO-1 specific antibody and T cell responses. However, it remains unclear whether heterologous prime-boost strategies based on the combination with NY-ESO-1 ISCOMATRIX with different NY-ESO-1 boosting reagents could be used to increase NY-ESO-1 CD8(+) or CD4(+) T cell responses. To address this question, we carried out a randomized clinical trial in 39 high-risk, resected melanoma patients vaccinated with NY-ESO-1 ISCOMATRIX, and then boosted with repeated injections of either recombinant fowlpox virus encoding full length NY-ESO-1 (rF-NY-ESO-1) (Arm A) or NY-ESO-1 ISCOMATRIX alone (Arm B). We have comprehensively analyzed NY-ESO-1 specific T cells and B cells response in all patients before and after vaccination for a total of seven time points per patient. NY-ESO-1 ISCOMATRIX alone elicited a strong NY-ESO-1 specific CD4(+) T cell and antibody response, which was maintained by both regiments at similar levels. However, CD8(+) T cell responses were significantly boosted in 3 out of 18 patients in Arm A after the first rF-NY-ESO-1 injection and such responses were maintained until the end of the trial, while no patients in Arm B showed similar CD8(+) T cell responses. In addition, our results clearly identified immunodominant regions in the NY-ESO-1 protein: NY-ESO-179-102 and NY-ESO-1115-138 for CD4+ T cells and NY-ESO-185-108 for CD8+ T cells in a large proportion of vaccinated patients. These regions of NY-ESO-1 protein should be considered in future clinical trials as immunodominant epitopes. © 2014 UICC.

  13. La estadística bidimensional en 4º ESO

    OpenAIRE

    Astarriaga Ros, Amaia

    2012-01-01

    Este trabajo fin de máster tiene como objetivo estudiar la enseñanza de la estadística bidimensional en 4º de ESO. El trabajo se estructura en dos partes. En la primera parte se realiza un estudio longitudinal del currículo y en los libros de texto en Primaria, en ESO y en Bachillerato con relación al tema indicado. En la segunda parte se propone un proceso de estudio sobre estadística bidimensional, que se ha puesto en marcha en un aula de 4º de ESO en el marco del Pract...

  14. Thirty years of pulsar studies at ESO. The Italian Contribution

    CERN Document Server

    Mignani, R P

    2012-01-01

    In May 1982, when Italy joined ESO, only two isolated neutron stars (INSs) had been identified in the optical: the Crab and Vela pulsars. Thanks to the ESO telescopes and the perseverance of a few Italian astronomers, now about 30 INSs have been identified in the optical/IR, and a new important channel in their multi-wavelength studies has been opened. In this contribution, I review the major steps in 30 years of INS studies at ESO, highlight the role of Italian astronomers, and introduce future perspectives with the E-ELT.

  15. Linking Publications and Observations: The ESO Telescope Bibliography

    Science.gov (United States)

    Meakins, S.; Grothkopf, U.

    2012-09-01

    Bibliometric studies have become increasingly important in evaluating individual scientists, specific facilities, and entire observatories. In this context, the ESO Library has developed and maintains two tools: FUSE, a full-text search tool, and the Telescope Bibliography (telbib), a content management system that is used to classify and annotate ESO-related scientific papers. The new public telbib interface provides faceted searches and filtering, autosuggest support for author, bibcode and program ID searches, hit highlighting as well as recommendations for other papers of possible interest. It is available at www.eso.org/libraries/telbib.html.

  16. Linking Publications and Observations - the ESO Telescope Bibliography

    CERN Document Server

    Meakins, Silvia

    2011-01-01

    Bibliometric studies have become increasingly important in evaluating individual scientists, specific facilities, and entire observatories. In this context, the ESO Library has developed and maintains two tools: FUSE, a full-text search tool, and the Telescope Bibliography (telbib), a content management system that is used to classify and annotate ESO-related scientific papers. The new public telbib interface provides faceted searches and filtering, autosuggest support for author, bibcode and program ID searches, hit highlighting as well as recommendations for other papers of possible interest. It is available at http://telbib.eso.org

  17. The ESO Adaptive Optics Facility under Test

    Science.gov (United States)

    Arsenault, Robin; Madec, Pierre-Yves; Paufique, Jerome; La Penna, Paolo; Stroebele, Stefan; Vernet, Elise; Pirard, Jean-François; Hackenberg, Wolfgang; Kuntschner, Harald; Kolb, Johann; Muller, Nicolas; Le Louarn, Miska; Amico, Paola; Hubin, Norbert; Lizon, Jean-Louis; Ridings, Rob; Abad, Jose; Fischer, Gert; Heinz, Volker; Kiekebusch, Mario; Argomedo, Javier; Conzelmann, Ralf; Tordo, Sebastien; Donaldson, Rob; Soenke, Christian; Duhoux, Philippe; Fedrigo, Enrico; Delabre, Bernard; Jost, Andrea; Duchateau, Michel; Downing, Mark; Moreno, Javier; Manescau, Antonio; Bonaccini Calia, Domenico; Quattri, Marco; Dupuy, Christophe; Guidolin, Ivan; Comin, Mauro; Guzman, Ronald; Buzzoni, Bernard; Quentin, Jutta; Lewis, Steffan; Jolley, Paul; Kraus, Max; Pfrommer, Thomas; Garcia-Rissmann, Aurea; Biasi, Roberto; Gallieni, Daniele; Stuik, Remko

    2013-12-01

    The Adaptive Optics Facility project has received most of its subsystems in Garching and the ESO Integration Hall has become the central operation location for the next phase of the project. The main test bench ASSIST and the 2nd Generation M2-Unit (hosting the Deformable Secondary Mirror) have been granted acceptance late 2012. The DSM will now undergo a series of tests on ASSIST to qualify its optical performance which launches the System Test Phase of the AOF. The tests will validate the AO modules operation with the DSM: first the GRAAL adaptive optics module for Hawk-I in natural guide star AO mode on-axis and then its Ground Layer AO mode. This will be followed by the GALACSI (for MUSE) Wide-Field-Mode (GLAO) and then the more challenging Narrow-Field-Mode (LTAO). We will report on the status of the subsystems at the time of the conference but also on the performance of the delivered ASSIST test bench, the DSM and the 20 Watt Sodium fiber Laser pre-production unit which has validated all specifications before final manufacturing of the serial units. We will also present some considerations and tools to ensure an efficient operation of the Facility in Paranal.

  18. El sistema ESO 296-IG 11

    Science.gov (United States)

    Agüero, E. L.; Paolantonio, S.

    El objeto ESO 296-IG 11 que se presenta en forma de ``V'' y posee destacadas condensaciones a lo largo de cada una de sus dos ramas, las que son de igual extensión (~ 1'), es estudiado en base a material espectroscópico obtenido en el CASLEO. Así se establecen las principales características espectrales, las condiciones físicas y los mecanismos de excitación dominantes de las zonas más notables de su estructura, como así también la distribución de su extinción interna y la variación del grado de excitación de las mismas. Del análisis de las velocidades radiales se determina que se trata de dos galaxias de tipo disco que se están interpenetrando y que conforman un sistema triple junto con una galaxia de contorno elíptico y tamaño considerablemente menor (0.2') que se encuentra a ~ 1.3' del punto de intersección de las dos primeras, ubicada sobre la dirección que contiene a una de éstas y hacia la que se extienden unas débiles y largas prolongaciones de la otra.

  19. The Gaia-ESO Survey: calibration strategy

    CERN Document Server

    Pancino, E

    2016-01-01

    The Gaia-ESO survey (GES) is now in its fifth and last year of observations, and has already produced tens of thousands of high-quality spectra of stars in all Milky Way components. This paper presents the strategy behind the selection of astrophysical calibration targets, ensuring that all GES results on radial velocities, atmospheric parameters, and chemical abundance ratios will be both internally consistent and easily comparable with other literature results, especially from other large spectroscopic surveys and from Gaia. The calibration of GES is particularly delicate because of: (i) the large space of parameters covered by its targets, ranging from dwarfs to giants, from O to M stars, and with a large range of metallicities, as well as including fast rotators, emission line objects, stars affected by veiling and so on; (ii) the variety of observing setups, with different wavelength ranges and resolution; and (iii) the choice of analyzing the data with many different state-of-the art methods, each stron...

  20. President of Czech Republic visits ESO's Paranal Observatory

    Science.gov (United States)

    2011-04-01

    On 6 April 2011, the ESO Paranal Observatory was honoured with a visit from the President of the Czech Republic, Václav Klaus, and his wife Livia Klausová, who also took the opportunity to admire Cerro Armazones, the future site of the planned E-ELT. The distinguished visitor was shown the technical installations at the observatory, and was present when the dome of one of the four 8.2-metre Unit Telescopes of ESO's Very Large Telescope opened for a night's observing at Cerro Paranal, the world's most advanced visible-light observatory. "I'm delighted to welcome President Klaus to the Paranal Observatory and to show him first-hand the world-leading astronomical facility that ESO has designed, has built, and operates for European astronomy," said ESO's Director General, Tim de Zeeuw. President Klaus replied, "I am very impressed by the remarkable technology that ESO has built here in the heart of the desert. Czech astronomers are already making good use of these facilities and we look forward to having Czech industry and its scientific community contribute to the future E-ELT." From the VLT platform, the President had the opportunity to admire Cerro Armazones as well as other spectacular views of Chile's Atacama Desert surrounding Paranal. Adjacent to Cerro Paranal, Armazones has been chosen as the site for the future E-ELT (see eso1018). ESO is seeking approval from its governing bodies by the end of 2011 for the go-ahead for the 1-billion euro E-ELT. Construction is expected to begin in 2012 and the start of operations is planned for early in the next decade. President Klaus was accompanied by the Minister of Foreign Affairs of the Czech Republic, Karel Schwarzenberg, the Czech Ambassador in Chile, Zdenek Kubánek, dignitaries of the government, and a Czech industrial delegation. The group was hosted at Paranal by the ESO Director General, Tim de Zeeuw, the ESO Representative in Chile, Massimo Tarenghi, the Director of Operations, Andreas Kaufer, and Jan Palous

  1. Young Astronomers' Observe with ESO Telescopes

    Science.gov (United States)

    1995-11-01

    Today, forty 16-18 year old students and their teachers are concluding a one-week, educational `working visit' to the ESO Headquarters in Garching (See ESO Press Release 14/95 of 8 November 1995). They are the winners of the Europe-wide contest `Europe Towards the Stars', organised by ESO with the support of the European Union, under the auspices of the Third European Week for Scientific and Technological Culture. From November 14-20, they have worked with professional ESO astronomers in order to get insight into the methods and principles of modern astronomy and astrophysics, as carried out at one of the world's foremost international centres. This included very successful remote observations with the ESO 3.5-m New Technology Telescope (NTT) and the 1.4-m Coude Auxiliary Telescope (CAT) via a satellite link between the ESO Headquarters and the La Silla observatory in Chile, 12,000 kilometres away. After a general introduction to modern astronomy on the first day of the visit, the participants divided into six teams, according to their interests. Some chose to observe distant galaxies, others prefered to have a closer look on binary stars, and one team decided to investigate a star which is thought to be surrounded by a proto-planetary system. Each team was supported by an experienced ESO astronomer. Then followed the observations at the remote consoles during three nights, the first at the NTT and the following at the CAT. Each team had access to the telescope during half a night. Although the work schedule - exactly as in `real' science - was quite hard, especially during the following data reduction and interpretative phase, all teams managed extremely well and in high spirits. The young astronomers' observations were favoured by excellent atmospheric conditions. At the NTT, the seeing was better than 0.5 arcsecond during several hours, an exceptional value that allows very good images to be obtained. All observations represent solid and interesting science, and

  2. Induction of primary NY-ESO-1 immunity: CD8+ T lymphocyte and antibody responses in peptide-vaccinated patients with NY-ESO-1+ cancers

    OpenAIRE

    Jäger, Elke; Gnjatic, Sacha; Nagata, Yasuhiro; Stockert, Elisabeth; Jäger, Dirk; Karbach, Julia; Neumann, Antje; Rieckenberg, Julia; Chen, Yao-Tseng; Ritter, Gerd; Hoffman, Eric; Arand, Michael; Old, Lloyd J.; Knuth, Alexander

    2000-01-01

    Cancer–testis antigen NY-ESO-1 is one of the most immunogenic tumor antigens defined to date. Spontaneous humoral and CD8+ T-cell responses to NY-ESO-1 are detected in 40–50% of patients with advanced NY-ESO-1-expressing tumors. A clinical trial was initiated to study the immunological effects of intradermal vaccination with 3 HLA-A2-binding NY-ESO-1 peptides in 12 patients with metastatic NY-ESO-1-expressing cancers. Seven patients were NY-ESO-1 serum antibody neg...

  3. Induction of primary NY-ESO-1 immunity: CD8+ T lymphocyte and antibody responses in peptide-vaccinated patients with NY-ESO-1+ cancers

    OpenAIRE

    2000-01-01

    Cancer–testis antigen NY-ESO-1 is one of the most immunogenic tumor antigens defined to date. Spontaneous humoral and CD8+ T-cell responses to NY-ESO-1 are detected in 40–50% of patients with advanced NY-ESO-1-expressing tumors. A clinical trial was initiated to study the immunological effects of intradermal vaccination with 3 HLA-A2-binding NY-ESO-1 peptides in 12 patients with metastatic NY-ESO-1-expressing cancers. Seven patients were NY-ESO-1 serum antibody neg...

  4. Science data management for ESO's La Silla Paranal Observatory

    Science.gov (United States)

    Romaniello, Martino

    2016-07-01

    Providing the best science data is at the core of ESO's mission to enable major science discoveries from its science community. We describe here the steps that ESO undertakes to fulfill this, namely ensuring that instruments are working properly, that the science content can be extracted from the data and, finally, delivering the science data to our users, PIs and archive researchers alike. Metrics and statistics that gauge the results and impact of these efforts are discussed.

  5. The ESO astronomical site monitor upgrade

    Science.gov (United States)

    Chiozzi, Gianluca; Sommer, Heiko; Sarazin, Marc; Bierwirth, Thomas; Dorigo, Dario; Vera Sequeiros, Ignacio; Navarrete, Julio; Del Valle, Diego

    2016-08-01

    Monitoring and prediction of astronomical observing conditions are essential for planning and optimizing observations. For this purpose, ESO, in the 90s, developed the concept of an Astronomical Site Monitor (ASM), as a facility fully integrated in the operations of the VLT observatory[1]. Identical systems were installed at Paranal and La Silla, providing comprehensive local weather information. By now, we had very good reasons for a major upgrade: • The need of introducing new features to satisfy the requirements of observing with the Adaptive Optics Facility and to benefit other Adaptive Optics systems. • Managing hardware and software obsolescence. • Making the system more maintainable and expandable by integrating off-the-shelf hardware solutions. The new ASM integrates: • A new Differential Image Motion Monitor (DIMM) paired with a Multi Aperture Scintillation Sensor (MASS) to measure the vertical distribution of turbulence in the high atmosphere and its characteristic velocity. • A new SLOpe Detection And Ranging (SLODAR) telescope, for measuring the altitude and intensity of turbulent layers in the low atmosphere. • A water vapour radiometer to monitor the water vapour content of the atmosphere. • The old weather tower, which is being refurbished with new sensors. The telescopes and the devices integrated are commercial products and we have used as much as possible the control system from the vendors. The existing external interfaces, based on the VLT standards, have been maintained for full backward compatibility. All data produced by the system are directly fed in real time into a relational database. A completely new web-based display replaces the obsolete plots based on HP-UX RTAP. We analyse here the architectural and technological choices and discuss the motivations and trade-offs.

  6. Efficacy of vaccination with recombinant vaccinia and fowlpox vectors expressing NY-ESO-1 antigen in ovarian cancer and melanoma patients.

    Science.gov (United States)

    Odunsi, Kunle; Matsuzaki, Junko; Karbach, Julia; Neumann, Antje; Mhawech-Fauceglia, Paulette; Miller, Austin; Beck, Amy; Morrison, Carl D; Ritter, Gerd; Godoy, Heidi; Lele, Shashikant; duPont, Nefertiti; Edwards, Robert; Shrikant, Protul; Old, Lloyd J; Gnjatic, Sacha; Jäger, Elke

    2012-04-10

    Recombinant poxviruses (vaccinia and fowlpox) expressing tumor-associated antigens are currently being evaluated in clinical trials as cancer vaccines to induce tumor-specific immune responses that will improve clinical outcome. To test whether a diversified prime and boost regimen targeting NY-ESO-1 will result in clinical benefit, we conducted two parallel phase II clinical trials of recombinant vaccinia-NY-ESO-1 (rV-NY-ESO-1), followed by booster vaccinations with recombinant fowlpox-NY-ESO-1 (rF-NY-ESO-1) in 25 melanoma and 22 epithelial ovarian cancer (EOC) patients with advanced disease who were at high risk for recurrence/progression. Integrated NY-ESO-1-specific antibody and CD4(+) and CD8(+) T cells were induced in a high proportion of melanoma and EOC patients. In melanoma patients, objective response rate [complete and partial response (CR+PR)] was 14%, mixed response was 5%, and disease stabilization was 52%, amounting to a clinical benefit rate (CBR) of 72% in melanoma patients. The median PFS in the melanoma patients was 9 mo (range, 0-84 mo) and the median OS was 48 mo (range, 3-106 mo). In EOC patients, the median PFS was 21 mo (95% CI, 16-29 mo), and median OS was 48 mo (CI, not estimable). CD8(+) T cells derived from vaccinated patients were shown to lyse NY-ESO-1-expressing tumor targets. These data provide preliminary evidence of clinically meaningful benefit for diversified prime and boost recombinant pox-viral-based vaccines in melanoma and ovarian cancer and support further evaluation of this approach in these patient populations.

  7. Autoimmune thyroid disease elicited by NY-ESO-1 vaccination.

    Science.gov (United States)

    Vita, Roberto; Guarneri, Fabrizio; Agah, Ravin; Benvenga, Salvatore

    2014-02-01

    Immunotherapies and targeted therapies are frequently associated with thyroid dysfunction, which is in contrast with the rare thyroid abnormalities induced by cytotoxic agents. Immunotherapy with NY-ESO-1, a tumor-associated antigen expressed by a number of malignancies, was reported to trigger hyperthyroidism or hypothyroidism in two HLA-A2 patients with ovarian cancer. We describe now a case of Graves' disease triggered by NY-ESO-1 in a HLA-A2-negative woman. A 32-year-old woman with a synovial sarcoma received radiotherapy, chemotherapy, and finally NY-ESO-1 vaccine. The patient was found to have HLA A11/A33(19), B13/B56(22), Cw3/-. One month after the beginning of immunotherapy, thyroid dysfunction was clinically suspected and Graves' disease was biochemically confirmed. Fearful of the antithyroid drugs' side effects, the patient was treated with a beta-blocker (propranolol, 80-20 mg/day). As hyperthyroidism progressively worsened, the patient underwent total thyroidectomy. We hypothesized that NY-ESO-1 shared partial homology with thyroid autoantigens (the so-called molecular mimicry mechanism) and that at least one pair of homologous sequences contained amino acid sequence binding motifs to a restricted number of HLA molecules. We used BLAST software to search amino acid sequence homologies between NY-ESO-1 and thyroid autoantigens (thyrotropin receptor [TSH-R], thyroperoxidase, and thyroglobulin), and the HLA ligand/motif database to look for HLA/T-cell receptor binding motifs in the regions of NY-ESO-1 and thyroid autoantigens that were homologous. We found 15 epitopic regions of NY-ESO-1 homologous to 15 regions of thyroid autoantigens, some of which epitopic: 5 of TSH-R, 8 of thyroglobulin, and 2 of thyroperoxidase. These homologous sequences contain binding motifs belonging to several HLA class I antigens, including HLA A2 and the patient's A11 and A33. Genetically predisposed patients who receive NY-ESO-1 vaccination are at risk to develop thyroid

  8. The Far-Ultraviolet Spectra of TW Hya. II. Models of H2 Fluorescence in a Disk

    CERN Document Server

    Herczeg, G J; Linsky, J L; Valenti, J A; Johns-Krull, C M; Herczeg, Gregory J.; Wood, Brian E.; Linsky, Jeffrey L.; Valenti, Jeff A.; Johns-Krull, Chris M.

    2004-01-01

    We measure the temperature of warm gas at planet-forming radii in the disk around the classical T Tauri star (CTTS) TW Hya by modelling the H2 fluorescence observed in HST/STIS and FUSE spectra. Strong Ly-alpha emission irradiates a warm disk surface within 2 AU of the central star and pumps certain excited levels of H2. We simulate a 1D plane-parallel atmosphere to estimate fluxes for the 140 observed H2 emission lines and to reconstruct the Ly-alpha emission profile incident upon the warm H2. The excitation of H2 can be determined from relative line strengths by measuring self-absorption in lines with low-energy lower levels, or by reconstructing the Ly-alpha profile incident upon the warm H2 using the total flux from a single upper level and the opacity in the pumping transition. Based on those diagnostics, we estimate that the warm disk surface has a column density of log N(H2)=18.5^{+1.2}_{-0.8}, a temperature T=2500^{+700}_{-500} K, and a filling factor of H2, as seen by the source of Ly-alpha emission,...

  9. Steepening of the 820 micron continuum surface-brightness profile signals dust evolution in TW Hya's disk

    CERN Document Server

    Hogerheijde, Michiel R; Pinilla, Paola; Salinas, Vachail N; Kama, Mihkel; Andrews, Sean M; Qi, Chunhua; Wilner, David J

    2015-01-01

    Grain growth in planet-forming disks is the first step toward the formation of planets. The growth of grains and their inward drift leaves a distinct imprint on the dust surface-density distribution and the resulting surface-brightness profile of the thermal continuum emission. We determine the surface-brightness profile of the continuum emission using resolved observations at millimeter wavelengths of the disk around TW Hya, and infer the signature of dust evolution on the surface density and dust opacity. Archival ALMA observations at 820 micron on baselines up to 410 kilolambda are compared to parametrized disk models to determine the surface-brightness profile. Under the assumption of a constant dust opacity, a broken radial power law best describes the dust surface density, with a slope of -0.53 +/- 0.01 from the 4.1 au radius of the (already known) inner hole to a turn-over radius of 47.1 +/- 0.2 au, steepening to -8.0 +/- 0.1 at larger radii. The emission drops below the detection limit beyond ~60 au. ...

  10. First Detection of UV emission from a Detached Dust Shell: GALEX Observations of the Carbon AGB Star U Hya

    CERN Document Server

    Sanchez, E; Ramstedt, S; Stassun, K G

    2014-01-01

    We present the discovery of an extended ring of ultraviolet emission surrounding the AGB star U Hya in archival observations performed by the Galaxy Evolution Explorer (GALEX). This is the third discovery of extended UV emission from a carbon AGB star and the first from an AGB star with a detached shell. From imaging and photometric analysis of the FUV and NUV images, we determined that the ultraviolet ring has a radius of $\\sim 110^{\\prime\\prime}$, thus indicating that the emitting material is likely associated with the detached shell seen in the infrared. We find that scattering of the central point source of NUV and FUV emission by the dust shell is negligible. Moreover, we find that scattering of the interstellar radiation field by the dust shell can contribute at most $\\sim10%$ of the FUV flux. Morphological and photometric evidence suggests that shocks caused by the star's motion through space and, possibly, shock-excited H$_2$ molecules are the most likely origins of the UV flux. In contrast to previou...

  11. Herschel/PACS view of disks around low-mass stars and brown dwarfs in the TW Hya association

    CERN Document Server

    Liu, Yao; Gong, Munan; Allers, Katelyn N; Brown, Joanna M; Kraus, Adam L; Liu, Michael C; Shkolnik, Evgenya L; van Dishoeck, Ewine F

    2014-01-01

    We conducted Herschel/PACS observations of five very low-mass stars or brown dwarfs located in the TW Hya association with the goal of characterizing the properties of disks in the low stellar mass regime. We detected all five targets at $70\\,\\mu{\\rm{m}}$ and $100\\,\\mu{\\rm{m}}$ and three targets at $160\\,\\mu{\\rm{m}}$. Our observations, combined with previous photometry from 2MASS, WISE, and SCUBA-2, enabled us to construct SEDs with extended wavelength coverage. Using sophisticated radiative transfer models, we analyzed the observed SEDs of the five detected objects with a hybrid fitting strategy that combines the model grids and the simulated annealing algorithm and evaluated the constraints on the disk properties via the Bayesian inference method. The modelling suggests that disks around low-mass stars and brown dwarfs are generally flatter than their higher mass counterparts, but the range of disk mass extends to well below the value found in T Tauri stars, and the disk scale heights are comparable in both...

  12. A Significantly Low CO Abundance Toward the TW Hya Protoplanetary Disk: A Path to Active Carbon Chemistry?

    CERN Document Server

    Favre, Cécile; Bergin, Edwin A; Qi, Chunhua; Blake, Geoffrey A

    2013-01-01

    In this Letter we report the CO abundance relative to H2 derived toward the circumstellar disk of the T-Tauri star TW Hya from the HD (1-0) and C18O (2-1) emission lines. The HD (1-0) line was observed by the Herschel Space Observatory Photodetector Array Camera and Spectrometer whereas C18O (2-1) observations were carried out with the Submillimeter Array at a spatial resolution of 2.8" x 1.9" (corresponding to 142 x 97 AU). In the disk's warm molecular layer (T>20 K) we measure a disk-averaged gas-phase CO abundance relative to H2 of $\\chi{\\rm(CO)}=(0.1-3)x10^{-5}$, substantially lower than the canonical value of $\\chi{\\rm(CO)}=10^{-4}$. We infer that the best explanation of this low $\\chi$(CO) is the chemical destruction of CO followed by rapid formation of carbon chains, or perhaps CO2, that can subsequently freeze-out, resulting in the bulk mass of carbon locked up in ice grain mantles and oxygen in water. As a consequence of this likely time-dependent carbon sink mechanism, CO may be an unreliable tracer...

  13. Variability of the Spin Period of the White Dwarf in the Magnetic Cataclysmic Binary System EX Hya

    CERN Document Server

    Andronov, Ivan L

    2013-01-01

    The observations of the two-periodic magnetic cataclysmic system EX Hya have been carried out, using the telescopes RC16 and TOA-150 of the Tzec Maun observatory. 6 nights of observations were obtained in 2010-2011 (alternatively changing filters VR). Also the databases of WASP, ASAS and AAVSO have been analyzed. Processing time series was carried out using the program MCV. We analyzed changes in the rotation period of the white dwarf, and based on our own and previously published moments of maximum. The ephemeris was determined for the maxima of the radiation flux associated with the rotation of the magnetic white dwarf: Tmax=2437699.89079(59) +0.0465464808(69).E-6.3(2)*10^{-13}E^2, which corresponds to the characteristic timescale of the rotation spin-up of 4.67(14)*10^6 years. This contradicts the estimated value of the mass of the white dwarf of 0.42M_\\odot, based on X-ray observations made by Yuasa et al (2010), however, is consistent with estimates of the masses of 0.79 M_\\odot (white dwarf) and 0.108 M...

  14. ESO celebrates 50 years of “Euro-astronomy”

    CERN Multimedia

    Anaïs Schaeffer

    2012-01-01

    Today the European Southern Observatory is celebrating its 50th anniversary. This article retraces the story of one of Europe's greatest laboratories, which came into being with CERN's support and assistance.   La Silla, June 1968. The three telescopes in the background are (from left to right): the Grand Prism Objectif (GPO, first light in 1968), the ESO 1 metre telescope (1966), and the ESO 1.5 metre telescope (1968). They have been decommissioned. The white dome closest to the viewer is the ESO 1 metre Schmidt telescope, which began work in 1971. Image: ESO/E. Maurice. In the spring of 1953, in Leiden in the Netherlands, a group of astronomers including Walter Baade, Jan Oort, Adriaan Blaauw, Otto Heckmann and Jan Bannier (who was then President of CERN's Provisional Council) for the first time discussed the possibility of founding a European space observatory. The objective was to build it in the southern hemisphere where there were very few observatories with pow...

  15. ESO Director General to Become President of AUI

    Science.gov (United States)

    1998-11-01

    The appointment of Professor Riccardo Giacconi , Director General of the European Southern Observatory (ESO) since January 1, 1993, to the Presidency of Associated Universities, Inc. ( AUI ) in the USA, has been jointly announced by Professor Paul C. Martin, Chair of AUI's Board of Trustees and Mr. Henrik Grage, President of the ESO Council. Professor Giacconi will assume this new position at the end of his term at ESO as of July 1, 1999. AUI is a not-for-profit science management corporation that operates the National Radio Astronomy Observatory ( NRAO) under a Cooperative Agreement with the National Science Foundation (NSF). Corporate headquarters are located in Washington, D.C. The President is its chief executive officer. Nine northeastern universities joined in founding AUI in 1946: Columbia University, Cornell University, Harvard University, The Johns Hopkins University, Massachusetts Institute of Technology, the University of Pennsylvania, Princeton University, the University of Rochester, and Yale University. Over the years, AUI has taken on a broad national character with a diversified Board of Trustees from universities and other institutions across the United States. ESO is an intergovernmental organization, at present with the following member countries: Belgium, Denmark, France, Germany, Italy, The Netherlands, Sweden and Switzerland. Portugal has an agreement with ESO aiming at full membership. ESO was founded in 1962 to establish and operate an astronomical observatory in the southern hemisphere and to promote and organize co-operation in astronomical research in Europe. While the ESO Headquarters are situated in Europe, the observing facilities are located in Chile (South America). The organization's main administrative and technical departments are located at the ESO Headquarters, in Garching near Munich, Germany. They include a number of highly specialized facilities, e.g. the optical, infrared, detector and instrumentation laboratories, all

  16. Las concepciones de los alumnos sobre el conflicto y la convivencia. Un estudio con alumnado de 4º de ESO

    OpenAIRE

    Pineda Alfonso, José Antonio

    2011-01-01

    Presentamos los resultados parciales de una investigación en curso, inscrita en el marco de una tesis doctoral, que ha partido del diseño de un “ámbito de investigación escolar” para la enseñanza de las Ciencias Sociales de 4º de ESO sobre el “conflicto y la convivencia” y se centra en el seguimiento de su experimentación con un grupo del IES Torreblanca de Sevilla durante el curso 2010- 2011. Ofrecemos una panorámica de las concepciones iniciales de los alumnos como paso pr...

  17. Aprendizaje significativo de la clasificación de los seres vivos en primero de la ESO

    OpenAIRE

    Grajeras Cid, Miriam

    2013-01-01

    En este trabajo fin de máster voy a abordar el tema de los seres vivos en 1º de la ESO ya que este fue el tema que impartí en el IESO Pedro de Atarrabia durante mi estancia en prácticas. En otras asignaturas del máster hemos visto como el alumnado de secundaria tiene muchos errores conceptuales, los cuales hay que corregir para que el alumnado tenga un aprendizaje significativo. Ante la dificultad de corregir estos errores, voy a desarrollar una propuesta didáctica en la que el alumnado apren...

  18. ESO Council Decides to Continue VLT Project at Paranal

    Science.gov (United States)

    1994-08-01

    The Council [1] of the European Southern Observatory has met in extraordinary session at the ESO Headquarters in Garching near Munich on August 8 and 9, 1994. The main agenda items were concerned with the recent developments around ESO's relations with the host state, the Republic of Chile, as well as the status of the organisation's main project, the 16-metre equivalent Very Large Telescope (VLT) which will become the world's largest optical telescope. Council had decided to hold this special meeting [2] because of various uncertainties that have arisen in connection with the implementation of the VLT Project at Cerro Paranal, approx. 130 kilometres south of Antofagasta, capital of the II Region in Chile. Following continued consultations at different levels within the ESO member states and after careful consideration of all aspects of the current situation - including various supportive actions by the Chilean Government as well as the incessive attacks against this international organisation from certain sides reported in the media in that country - Council took the important decision to continue the construction of the VLT Observatory at Paranal, while at the same time requesting the ESO Management to pursue the ongoing studies of alternative solutions. THE COUNCIL DECISIONS In particular, the ESO Council took note of recent positive developments which have occurred since the May 1994 round of discussions with the Chilean authorities in Santiago. The confirmation of ESO's immunities as an International Organization in Chile, contained in a number of important statements and documents, is considered a significant step by the Chilean Government to insure to ESO the unhindered erection and later operation of the VLT on Paranal. Under these circumstances and in order to maintain progress on the VLT project, the ESO Council authorized the ESO Management to continue the on-site work at Paranal. Council also took note of the desire expressed by the Chilean Government

  19. ESO Archive Operations in support of Services in Garching

    Science.gov (United States)

    Fourniol, Nathalie

    2015-12-01

    ESO Science Archive Facility (SAF) is the unique access point to the La Silla Paranal Observatory (LPO) raw data. It also services data products created at ESO with state-of-the-art pipelines, or fed back by the external astronomical community. ESO SAF is a big success in the sense that users access the data every single day, and they want their data fast! A copy of the ALMA Science Archive (ASA) is also accessible at Garching to the European ALMA community via the European ALMA Regional Center. A data portal allows users to get access to the data. In this poster we present the Archive Operations in support of services in Garching, from archiving the data to making them available to the community.

  20. Trabajando con la lengua: ¡Manos a la obra! Programación didáctica de 4º de la ESO

    OpenAIRE

    García Delgado, Mar

    2016-01-01

    Este Trabajo de Fin de Máster va a estar dividido en tres partes: una valoración de los conocimientos aprendidos en la universidad y en las prácticas en los institutos, una programación didáctica para cuarto de la ESO y una innovación docente también para este curso.

  1. Gene expression profiling in gills of the great spider crab Hyas araneus in response to ocean acidification and warming.

    Science.gov (United States)

    Harms, Lars; Frickenhaus, Stephan; Schiffer, Melanie; Mark, Felix Christopher; Storch, Daniela; Held, Christoph; Pörtner, Hans-Otto; Lucassen, Magnus

    2014-09-12

    Hypercapnia and elevated temperatures resulting from climate change may have adverse consequences for many marine organisms. While diverse physiological and ecological effects have been identified, changes in those molecular mechanisms, which shape the physiological phenotype of a species and limit its capacity to compensate, remain poorly understood. Here, we use global gene expression profiling through RNA-Sequencing to study the transcriptional responses to ocean acidification and warming in gills of the boreal spider crab Hyas araneus exposed medium-term (10 weeks) to intermediate (1,120 μatm) and high (1,960 μatm) PCO2 at different temperatures (5°C and 10°C). The analyses reveal shifts in steady state gene expression from control to intermediate and from intermediate to high CO2 exposures. At 5°C acid-base, energy metabolism and stress response related genes were upregulated at intermediate PCO2, whereas high PCO2 induced a relative reduction in expression to levels closer to controls. A similar pattern was found at elevated temperature (10°C). There was a strong coordination between acid-base, metabolic and stress-related processes. Hemolymph parameters at intermediate PCO2 indicate enhanced capacity in acid-base compensation potentially supported by upregulation of a V-ATPase. The likely enhanced energy demand might be met by the upregulation of the electron transport system (ETS), but may lead to increased oxidative stress reflected in upregulated antioxidant defense transcripts. These mechanisms were attenuated by high PCO2, possibly as a result of limited acid-base compensation and metabolic down-regulation. Our findings indicate a PCO2 dependent threshold beyond which compensation by acclimation fails progressively. They also indicate a limited ability of this stenoecious crustacean to compensate for the effects of ocean acidification with and without concomitant warming.

  2. BANYAN. IX. The Initial Mass Function and Planetary-mass Object Space Density of the TW HYA Association

    Science.gov (United States)

    Gagné, Jonathan; Faherty, Jacqueline K.; Mamajek, Eric E.; Malo, Lison; Doyon, René; Filippazzo, Joseph C.; Weinberger, Alycia J.; Donaldson, Jessica K.; Lépine, Sébastien; Lafrenière, David; Artigau, Étienne; Burgasser, Adam J.; Looper, Dagny; Boucher, Anne; Beletsky, Yuri; Camnasio, Sara; Brunette, Charles; Arboit, Geneviève

    2017-02-01

    A determination of the initial mass function (IMF) of the current, incomplete census of the 10 Myr-old TW Hya association (TWA) is presented. This census is built from a literature compilation supplemented with new spectra and 17 new radial velocities from ongoing membership surveys, as well as a reanalysis of Hipparcos data that confirmed HR 4334 (A2 Vn) as a member. Although the dominant uncertainty in the IMF remains census incompleteness, a detailed statistical treatment is carried out to make the IMF determination independent of binning while accounting for small number statistics. The currently known high-likelihood members are fitted by a log-normal distribution with a central mass of {0.21}-0.06+0.11 M ⊙ and a characteristic width of {0.8}-0.1+0.2 dex in the 12 M Jup–2 M ⊙ range, whereas a Salpeter power law with α ={2.2}-0.5+1.1 best describes the IMF slope in the 0.1–2 M ⊙ range. This characteristic width is higher than other young associations, which may be due to incompleteness in the current census of low-mass TWA stars. A tentative overpopulation of isolated planetary-mass members similar to 2MASS J11472421–2040204 and 2MASS J11193254–1137466 is identified: this indicates that there might be as many as {10}-5+13 similar members of TWA with hot-start model-dependent masses estimated at ∼5–7 M Jup, most of which would be too faint to be detected in 2MASS. Our new radial velocity measurements corroborate the membership of 2MASS J11472421–2040204, and secure TWA 28 (M8.5 γ), TWA 29 (M9.5 γ), and TWA 33 (M4.5 e) as members. The discovery of 2MASS J09553336–0208403, a young L7-type interloper unrelated to TWA, is also presented.

  3. PROP: ESO's portal for reporting of operational problematics

    Science.gov (United States)

    Marteau, S.; Rahimpour, S.; Lockhart, J.

    2012-09-01

    The ESO Portal for Reporting of Operational Problematics, aka PROP, allows members of the astronomical community to use a single access point to contact various operational groups at ESO. From the inside, operations staff can use the tool to communicate with their colleagues within the frame of problem resolution while keeping all the information in one place. It also opens the possibility to compile a knowledge base and to easily derive statistics on problem resolution, e.g. to monitor better the quality of service.

  4. Topology Optimization in Damping Structure Based on ESO

    Institute of Scientific and Technical Information of China (English)

    GUO Zhong-ze; CHEN Yu-ze; HOU Qiang

    2008-01-01

    The damping material optimal placement for the structure with damping layer is studied based on evolutionary structural optimization (ESO) to maximize modal loss factors. A mathematical model is constructed with the objective function defined as the maximum of modal loss factors of the structure and design constraints function defined as volume fraction ofdamping material. The optimal placement is found. Several examples are presented for verification. The results demonstratethat the method based on ESO is effective in solving the topology optimization of the structure with uncon-strained damping layer and constrained damping layer. This optimization method suits for free and constrained damping structures.

  5. Novel Fault Diagnosis Scheme for HVDC System via ESO

    Institute of Scientific and Technical Information of China (English)

    YAN Bing-yong; TIAN Zuo-hua; SHI Song-jiao

    2007-01-01

    A novel fault detection and identification (FDI) scheme for HVDC (High Voltage Direct Current Transmission) system was presented. It was based on the unique active disturbance rejection concept, where the HVDC system faults were estimated using an extended states observer (ESO). Firstly, the mathematical model of HVDC system was constructed, where the system states and disturbance were treated as an extended state. An augment HVDC system was established by using the extended state in rectify side and converter side, respectively. Then, a fault diagnosis filter was established to diagnose the HVDC system faults via the ESO theory. The evolution of the extended state in the augment HVDC system can reflect the actual system faults and disturbances, which can be used for the fault diagnosis purpose. A novel feature of this approach is that it can simultaneously detect and identify the shape and magnitude of the HVDC faults and disturbance. Finally, different kinds of HVDC faults were simulated to illustrate the feasibility and effectiveness of the proposed ESO based FDI approach. Compared with the neural network based or support vector machine based FDI approach, the ESO based FDI scheme can reduce the fault detection time dramatically and track the actual system fault accurately. What's more important, it needs not do complex online calculations and the training of neural network so that it can be applied into practice.

  6. Therapeutical solutions for non-malignant eso-bronchial fistulas.

    Science.gov (United States)

    Galie, N; Grigorie, V

    2009-01-01

    We assessed the efficacy of surgical treatment for the patients with eso-respiratory fistulas. The following cases revealed the anesthesic and surgical difficulties, and also intraoperative and postoperative complications that can occur when the esophageal contents get into the respiratory system. In these situations, therapy must be adapted according to fistula's topography and etiology, and also to patients' biological conditions.

  7. Therapeutical solutions for non-malignant eso-bronchial fistulas

    OpenAIRE

    Galie, N; Grigorie, V

    2009-01-01

    We assessed the efficacy of surgical treatment for the patients with eso-respiratory fistulas. The following cases revealed the anesthesic and surgical difficulties, and also intraoperative and postoperative complications that can occur when the esophageal contents get into the respiratory system. In these situations, therapy must be adapted according to fistula’s topography and etiology, and also to patients’ biological conditions.

  8. The ESO Imaging Survey Status Report and Preliminary Results

    CERN Document Server

    Da Costa, L N; Deul, E; Erben, T; Freudling, W; Guarnieri, M D; Hook, I; Hook, R N; Méndez, R; Nonino, M; Olsen, L; Prandoni, I; Renzini, A; Savaglio, S; Scodeggio, M; Silva, D; Slijkhuis, R; Wicenec, A; Wichmann, R; Benoist, C

    1998-01-01

    The ESO Imaging Survey (EIS) presented in early issues of the Messenger, and with up-to-date information on the ongoing observations available on the Web (http://www.eso.org/eis), is a concerted effort by ESO and the Member State community to provide targets for the first year of operation of the VLT. It consists of two parts: a relatively wide-angle survey (EIS-WIDE) to cover four pre-selected patches of sky, 6 square degrees each, spread in right ascension to search for distant clusters and quasars and a deep, multicolor survey of four optical (SUSI-2) and two infrared (SOFI) covering the HST/Hubble Deep Field South (HDFS) and its flanking fields (EIS-DEEP). From the start, the main challenge has been to carry out a public survey in a limited amount of time requiring observations, software development and data reduction with the goal of distributing the survey data products before the call for proposal for the VLT. To cope with this one-year timetable, a novel type of collaboration between ESO and the commu...

  9. ESDIS Standards Office (ESO): Requirements, Standards and Practices

    Science.gov (United States)

    Mitchell, Andrew E.; Mcinerney, Mark Allen; Enloe, Yonsok K.; Conover, Helen T.; Doyle, Allan

    2016-01-01

    The ESDIS Standards Office assists the ESDIS Project in formulating standards policy for NASA Earth Science Data Systems (ESDS), coordinates standards activities within ESDIS, and provides technical expertise and assistance with standards related tasks within the NASA Earth Science Data System Working Groups (ESDSWG). This poster summarizes information found on the earthdata.nasa.gov site that describes the ESO.

  10. ESO Ultra HD Expedition: New clarity for astronomy outreach

    Science.gov (United States)

    Laird, R. J. M.; Christensen, L. L.

    2014-12-01

    In the spring of 2014 a team of ESO Photo Ambassadors embarked on a pioneering expedition to the European Southern Observatory's observing sites in Chile. Their mission was to capture time-lapses, stills, videos and panoramas in crisp Ultra High Definition from some of the darkest night skies on Earth.

  11. Entre las prácticas y los paradigmas

    OpenAIRE

    2006-01-01

    Las descripciones historicistas, sociológicas y antropológicas se han visto sacudidas por procesos rizomáticos, inexplicables y sorprendentes en materia de imaginarios, configuraciones, expresividades, en tanto mundo y en cuanto forma. El arte, en tanto materia comunicante de imposible funcionalismo; sus prácticas siguen poniendo en juego, en jaque, los abordamientos científicos, sin que por eso debamos desestimar las contribuciones parciales, las entregas acotadas y las percepciones particul...

  12. Hubble and ESO's VLT provide unique 3D views of remote galaxies

    Science.gov (United States)

    2009-03-01

    Astronomers have obtained exceptional 3D views of distant galaxies, seen when the Universe was half its current age, by combining the twin strengths of the NASA/ESA Hubble Space Telescope's acute eye, and the capacity of ESO's Very Large Telescope to probe the motions of gas in tiny objects. By looking at this unique "history book" of our Universe, at an epoch when the Sun and the Earth did not yet exist, scientists hope to solve the puzzle of how galaxies formed in the remote past. ESO PR Photo 10a/09 A 3D view of remote galaxies ESO PR Photo 10b/09 Measuring motions in 3 distant galaxies ESO PR Video 10a/09 Galaxies in collision For decades, distant galaxies that emitted their light six billion years ago were no more than small specks of light on the sky. With the launch of the Hubble Space Telescope in the early 1990s, astronomers were able to scrutinise the structure of distant galaxies in some detail for the first time. Under the superb skies of Paranal, the VLT's FLAMES/GIRAFFE spectrograph (ESO 13/02) -- which obtains simultaneous spectra from small areas of extended objects -- can now also resolve the motions of the gas in these distant galaxies (ESO 10/06). "This unique combination of Hubble and the VLT allows us to model distant galaxies almost as nicely as we can close ones," says François Hammer, who led the team. "In effect, FLAMES/GIRAFFE now allows us to measure the velocity of the gas at various locations in these objects. This means that we can see how the gas is moving, which provides us with a three-dimensional view of galaxies halfway across the Universe." The team has undertaken the Herculean task of reconstituting the history of about one hundred remote galaxies that have been observed with both Hubble and GIRAFFE on the VLT. The first results are coming in and have already provided useful insights for three galaxies. In one galaxy, GIRAFFE revealed a region full of ionised gas, that is, hot gas composed of atoms that have been stripped of

  13. Clumpy dust clouds and extended atmosphere of the AGB star W Hya revealed with VLT/SPHERE-ZIMPOL and VLTI/AMBER

    CERN Document Server

    Ohnaka, Keiichi; Hofmann, Karl-Heinz

    2016-01-01

    We present visible polarimetric imaging observations of the well-studied AGB star W Hya taken with VLT/SPHERE-ZIMPOL as well as high spectral resolution long-baseline interferometric observations with the AMBER instrument of the Very Large Telescope Interferometer (VLTI). We observed W Hya with VLT/SPHERE-ZIMPOL at three wavelengths in the continuum (645, 748, and 820 nm), in the Halpha line at 656.3 nm, and in the TiO band at 717 nm. The VLTI/AMBER observations were carried out in the wavelength region of the CO first overtone lines near 2.3 micron with a spectral resolution of 12000. Taking advantage of the polarimetric imaging capability of SPHERE-ZIMPOL combined with the superb adaptive optics performance, we have succeeded in spatially resolving three clumpy dust clouds located at ~50 mas (~2 Rstar) from the central star, revealing dust formation very close to the star. The AMBER data in the individual CO lines suggest a molecular outer atmosphere extending to ~3 Rstar. Furthermore, the SPHERE-ZIMPOL ima...

  14. NY-ESO-1 cancer testis antigen demonstrates high immunogenicity in triple negative breast cancer.

    Science.gov (United States)

    Ademuyiwa, Foluso O; Bshara, Wiam; Attwood, Kristopher; Morrison, Carl; Edge, Stephen B; Karpf, Adam R; James, Smith A; Ambrosone, Christine B; O'Connor, Tracey L; Levine, Ellis G; Miliotto, Anthony; Ritter, Erika; Ritter, Gerd; Gnjatic, Sacha; Odunsi, Kunle

    2012-01-01

    NY-ESO-1 cancer testis (CT) antigen is an attractive candidate for immunotherapy as a result of its high immunogenicity. The aim of this study was to explore the potential for NY-ESO-1 antigen directed immunotherapy in triple negative breast cancer (TNBC) by determining the frequency of expression by immunohistochemistry (IHC) and the degree of inherent immunogenicity to NY-ESO-1. 168 TNBC and 47 ER+/HER2- primary breast cancer specimens were used to determine NY-ESO-1 frequency by IHC. As previous studies have shown that patients with a robust innate humoral immune response to CT antigens are more likely to develop CD8 T-cell responses to NY-ESO-1 peptides, we evaluated the degree to which patients with NY-ESO-1 expression had inherent immunogenicity by measuring antibodies. The relationship between NY-ESO-1 expression and CD8+ T lymphocytes was also examined. The frequency of NY-ESO-1 expression in the TNBC cohort was 16% versus 2% in ER+/HER2- patients. A higher NY-ESO-1 score was associated with a younger age at diagnosis in the TNBC patients with NY-ESO-1 expression (p = 0.026). No differences in OS (p = 0.278) or PFS (p = 0.238) by NY-ESO-1 expression status were detected. Antibody responses to NY-ESO-1 were found in 73% of TNBC patients whose tumors were NY-ESO-1 positive. NY-ESO-1 positive patients had higher CD8 counts than negative patients (p = 0.018). NY-ESO-1 is expressed in a substantial subset of TNBC patients and leads to a high humoral immune response in a large proportion of these individuals. Given these observations, patients with TNBC may benefit from targeted therapies directed against NY-ESO-1.

  15. Photographic photometry of 16000 galaxies on ESO blue and red survey plates

    NARCIS (Netherlands)

    Lauberts, A.; Valentijn, E. A.

    1985-01-01

    An ongoing photometric survey of 16,000 galaxies on ESO red and blue plates is described. The galaxies of the ESO/Uppsala Catalog (Lauberts, 1982) are being PDS scanned, and the results are combined with existing photometry and supplementary observational data obtained at the 1-m ESO telescope to fo

  16. Photographic photometry of 16000 galaxies on ESO blue and red survey plates

    NARCIS (Netherlands)

    Lauberts, A.; Valentijn, E. A.

    1985-01-01

    An ongoing photometric survey of 16,000 galaxies on ESO red and blue plates is described. The galaxies of the ESO/Uppsala Catalog (Lauberts, 1982) are being PDS scanned, and the results are combined with existing photometry and supplementary observational data obtained at the 1-m ESO telescope to

  17. Photographic photometry of 16000 galaxies on ESO blue and red survey plates

    NARCIS (Netherlands)

    Lauberts, A.; Valentijn, E. A.

    1985-01-01

    An ongoing photometric survey of 16,000 galaxies on ESO red and blue plates is described. The galaxies of the ESO/Uppsala Catalog (Lauberts, 1982) are being PDS scanned, and the results are combined with existing photometry and supplementary observational data obtained at the 1-m ESO telescope to fo

  18. If we build it, will they come? Curation and use of the ESO telescope bibliography

    Science.gov (United States)

    Grothkopf, Uta; Meakins, Silvia; Bordelon, Dominic

    2015-12-01

    The ESO Telescope Bibliography (telbib) is a database of refereed papers published by the ESO users community. It links data in the ESO Science Archive with the published literature, and vice versa. Developed and maintained by the ESO library, telbib also provides insights into the organization's research output and impact as measured through bibliometric studies. Curating telbib is a multi-step process that involves extensive tagging of the database records. Based on selected use cases, this talk will explain how the rich metadata provide parameters for reports and statistics in order to investigate the performance of ESO's facilities and to understand trends and developments in the publishing behaviour of the user community.

  19. The Gaia-ESO Survey: Tracing interstellar extinction

    CERN Document Server

    Schultheis, M; Recio-Blanco, A; de Laverny, P; Hill, V; Gilmore, G; Alfaro, E J; Costado, M T; Bensby, T; Damiani, F; Feltzing, S; Flaccomio, E; Lardo, C; Jofre, P; Prisinzano, L; Zaggia, S; Jimenez-Esteban, F; Morbidelli, L; Lanzafame, A C; Hourihane, A; Worley, C; Francois, P

    2015-01-01

    Large spectroscopic surveys have enabled in the recent years the computation of three-dimensional interstellar extinction maps thanks to accurate stellar atmospheric parameters and line-of-sight distances. Such maps are complementary to 3D maps extracted from photometry, allowing a more thorough study of the dust properties. Our goal is to use the high-resolution spectroscopic survey Gaia-ESO in order to obtain with a good distance resolution the interstellar extinction and its dependency as a function of the environment and the Galactocentric position. We use the stellar atmospheric parameters of more than 5000 stars, obtained from the Gaia-ESO survey second internal data release, and combine them with optical (SDSS) and near-infrared (VISTA) photometry as well as different sets of theoretical stellar isochrones, in order to calculate line-of-sight extinction and distances. The extinction coefficients are then compared with the literature to discuss their dependancy on the stellar parameters and position in ...

  20. An Isolated HII Region near ESO 481-G017

    CERN Document Server

    Santiago-Figueroa, N; Werk, J; Ryan-Weber, E; Meurer, G

    2009-01-01

    We obtained VLA 21-cm observations of the galaxy ESO 481-G017 to determine the environment and trigger of remote star formation traced by a HII region found 43 kpc from the galaxy (in projection). ESO 481-G017 is an early type spiral galaxy with a HI mass of 1.1*10^9 Msun and a distance of 55 Mpc. The isolated HII region has a H-alpha luminosity of 10^38.1 erg s^-1 and minimal continuum emission suggesting that new stars have formed where little or no stars previously existed. The difference in velocity between the HI disk of ESO 481-G017 (3840-4000 km s^-1) and the isolated HII region (4701 +/- 80 km s^-1) indicates the origin of the HII region may be stars forming in a tidal feature or newly triggered star formation in a very low luminosity companion galaxy. The VLA observations shed light on the nature of this young object.

  1. Reaching New Heights in Astronomy - ESO Long Term Perspectives

    Science.gov (United States)

    de Zeeuw, T.

    2016-12-01

    A comprehensive description of ESO in the current global astronomical context, and its plans for the next decade and beyond, are presented. This survey covers all aspects of the Organisation, including the optical-infrared programme at the La Silla Paranal Observatory, the submillimetre facilities ALMA and APEX, the construction of the 39-metre European Extremely Large Telescope and the science operation of these facilities. An extension of the current optical/infrared/submillimetre facilities into multi-messenger astronomy has been made with the decision to host the southern Cherenkov Telescope Array at Paranal. The structure of the Organisation is presented and the further development of the staff is described within the scope of the long-range financial planning. The role of Chile is highlighted and expansion of the number of Member States beyond the current 15 is discussed. The strengths of the ESO model, together with challenges as well as possible new opportunities and initiatives, are examined and a strategy for the future of ESO is outlined.

  2. Experimentos de cátedra para los contenidos de Física y Química de 4º de E.S.O.

    OpenAIRE

    Carmona Balea, Antia

    2014-01-01

    Las experiencias de cátedra son experiencias que realiza el profesor en el aula buscando una mayor comprensión de la teoría y de su aplicación práctica por parte del alumnado. En este trabajo se detallan 13 experimentos de cátedra para los contenidos de Física y Química de la asignatura de 4º de E.S.O. La asignatura de Física y Química de 4º de la E.S.O es de carácter optativo por lo que en este trabajo se presupone que el alumnado este motivado respecto a las enseñanzas de ciencias, ...

  3. Tutoría en 1º de la ESO. Necesidad de adultos de referencia en el paso del CEIP al IES en la Comunidad de Madrid

    OpenAIRE

    Agustín MUÑOZ PÉREZ

    2016-01-01

    La elaboración de la presente tesis doctoral encuentra su punto de partida en la práctica docente de más de 30 años como maestro que ha vivido con intensidad la función de tutoría con mis alumnos del ciclo superior de EGB, en Programas de Garantía Social, siendo adjunto a jefatura de estudios encargado de 1º de ESO y, actualmente, como tutor del mismo curso. Considero que 1º de ESO, en la enseñanza pública, es de especial relevancia por la doble transición que vive el alumnado: psicológica, a...

  4. 欧洲南方天文台(ESO)总部扩建%Extension of the ESO Headquarters

    Institute of Scientific and Technical Information of China (English)

    意大利IaN+建筑设计

    2010-01-01

    @@ 设计理念 欧洲南方天文台(ESO)总部扩建方案力求打造一座完全融入周边景观地貌的办公建筑.使工作人员无论工作或是漫步于ESO的办公室中均可享受到周边环境的景观地貌.

  5. Antibody Responses to NY-ESO-1 in Primary Breast Cancer Identify a Subtype Target for Immunotherapy

    OpenAIRE

    2011-01-01

    The highly immunogenic human tumor antigen NY-ESO-1 (ESO) is a target of choice for anti-cancer immune therapy. In this study, we assessed spontaneous antibody (Ab) responses to ESO in a large cohort of patients with primary breast cancer (BC) and addressed the correlation between the presence of anti-ESO Ab, the expression of ESO in the tumors and their characteristics. We found detectable Ab responses to ESO in 1% of the patients. Tumors from patients with circulating Ab to ESO exhibited co...

  6. NY-ESO-1 antibody as a novel tumour marker of gastric cancer.

    Science.gov (United States)

    Fujiwara, S; Wada, H; Kawada, J; Kawabata, R; Takahashi, T; Fujita, J; Hirao, T; Shibata, K; Makari, Y; Iijima, S; Nishikawa, H; Jungbluth, A A; Nakamura, Y; Kurokawa, Y; Yamasaki, M; Miyata, H; Nakajima, K; Takiguchi, S; Nakayama, E; Mori, M; Doki, Y

    2013-03-19

    NY-ESO-1 antibodies are specifically observed in patients with NY-ESO-1-expressing tumours. We analysed whether the NY-ESO-1 humoral immune response is a useful tumour marker of gastric cancer. Sera from 363 gastric cancer patients were screened by enzyme-linked immunosorbent assay (ELISA) to detect NY-ESO-1 antibodies. Serial serum samples were obtained from 25 NY-ESO-1 antibody-positive patients, including 16 patients with curative resection and 9 patients who received chemotherapy alone. NY-ESO-1 antibodies were detected in 3.4% of stage I, 4.4% of stage II, 25.3% of stage III, and 20.0% of stage IV patients. The frequency of antibody positivity increased with disease progression. When the NY-ESO-1 antibody was used in combination with carcinoembryonic antigen and CA19-9 to detect gastric cancer, information gains of 11.2% in stages III and IV, and 5.8% in all patients were observed. The NY-ESO-1 immune response levels of the patients without recurrence fell below the cutoff level after surgery. Two of the patients with recurrence displayed incomplete decreases. The nine patients who received chemotherapy alone continued to display NY-ESO-1 immune responses. When combined with conventional tumour markers, the NY-ESO-1 humoral immune response could be a useful tumour marker for detecting advanced gastric cancer and inferring the post-treatment tumour load in seropositive patients.

  7. NY-ESO-1 expression and immunogenicity in prostate cancer patients.

    Science.gov (United States)

    Gati, Asma; Lajmi, Nesrine; Derouiche, Amine; Marrakchi, Raja; Chebil, Mohamed; Benammar-Elgaaied, Amel

    2011-10-01

    Prostate cancer is the second leading cause of men cancer-related death. Cancer immunotherapy has been investigated as a treatment which might be instituted at the point of detection of androgen-independent metastatic disease. to investigate the expression and humoral response against NYESO-1 in patients with prostate cancer (PC) and to analyze the relationship between expression of NY-ESO-1 and clinicopathological features. NY-ESO-1 mRNA in surgically resected PC and benign prostatic hyperplasia (BPH) were examined by reverse transcriptionpolymerase chain reaction. The antibody response to NY-ESO-1 was examined by enzyme-linked Elisa assay using recombinant NYESO-1 protein. NY-ESO-1 mRNA was detected in 9 of 23 (39%) PC patients. Antibodies against NY-ESO-1 protein were detected in 12 of 23 (52%) sera of PC patients and in 5 of 9 (55%) of NY-ESO-1 expressing tumors. However, no mRNA copy or NY-ESO-1 antibodies were detected in all BPH patients tested. The present study has demonstrated the expression of NY-ESO-1mRNA in prostate Cancer patients and NY-ESO-1 antibody production. Our data suggest that NY-ESO-1 could be used as a tumor marker and constitute a good candidate for vaccine-based immunotherapy for hormonal resistant prostate cancer patients.

  8. NY-ESO-1 expression predicts an aggressive phenotype of ovarian cancer.

    Science.gov (United States)

    Szender, J Brian; Papanicolau-Sengos, Antonios; Eng, Kevin H; Miliotto, Anthony J; Lugade, Amit A; Gnjatic, Sacha; Matsuzaki, Junko; Morrison, Carl D; Odunsi, Kunle

    2017-06-01

    NY-ESO-1 is a cancer testis antigen and a promising target for immunotherapy. The purpose of this study was to determine the expression frequency, immunogenicity, and clinical impact of NY-ESO-1 in ovarian cancer. Immunohistochemistry (IHC), reverse-transcription polymerase chain reaction (RT-PCR), and quantitative-PCR (qRT-PCR) were utilized in an ovarian cancer (including Fallopian tube and primary peritoneal cancers) patient cohort; humoral responses against NY-ESO-1 were determined by ELISA. Clinicopathologic outcomes including progression-free (PFS) and overall (OS) survival were evaluated based on NY-ESO-1 expression. Cohen's kappa (κ) tested agreement between expression tests. NY-ESO-1 expression was detected by any method in 40.7% of 1002 patients' tumors (NY-ESO-1+) and baseline humoral response was identified in 19.0% of 689 tested patients. NY-ESO-1+ patients were older (pESO-1+ patients. A subset analysis of NY-ESO-1+ patients that received immunotherapy demonstrated improved OS by >2years (52.6 vs. 27.2months, pESO-1 expression and an aggressive cancer phenotype. The relatively high expression frequency of NY-ESO-1 in ovarian cancer patients coupled with the poor clinical outcomes in NY-ESO-1+ patients reveals an underappreciated need for targeted therapy against this antigen. In support, our study reveals that NY-ESO-1+ patients enrolled on immunotherapy trials targeting the antigen exhibited an improvement in OS. Copyright © 2017 Elsevier Inc. All rights reserved.

  9. Vaccination with NY-ESO-1 overlapping peptides mixed with Picibanil OK-432 and montanide ISA-51 in patients with cancers expressing the NY-ESO-1 antigen.

    Science.gov (United States)

    Wada, Hisashi; Isobe, Midori; Kakimi, Kazuhiro; Mizote, Yu; Eikawa, Shingo; Sato, Eiichi; Takigawa, Nagio; Kiura, Katsuyuki; Tsuji, Kazuhide; Iwatsuki, Keiji; Yamasaki, Makoto; Miyata, Hiroshi; Matsushita, Hirokazu; Udono, Heiichiro; Seto, Yasuyuki; Yamada, Kazuhiro; Nishikawa, Hiroyoshi; Pan, Linda; Venhaus, Ralph; Oka, Mikio; Doki, Yuichiro; Nakayama, Eiichi

    2014-01-01

    We conducted a clinical trial of an NY-ESO-1 cancer vaccine using 4 synthetic overlapping long peptides (OLP; peptides #1, 79-108; #2, 100-129; #3, 121-150; and #4, 142-173) that include a highly immunogenic region of the NY-ESO-1 molecule. Nine patients were immunized with 0.25 mg each of three 30-mer and a 32-mer long NY-ESO-1 OLP mixed with 0.2 KE Picibanil OK-432 and 1.25 mL Montanide ISA-51. The primary endpoints of this study were safety and NY-ESO-1 immune responses. Five to 18 injections of the NY-ESO-1 OLP vaccine were well tolerated. Vaccine-related adverse events observed were fever and injection site reaction (grade 1 and 2). Two patients showed stable disease after vaccination. An NY-ESO-1-specific humoral immune response was observed in all patients and an antibody against peptide #3 (121-150) was detected firstly and strongly after vaccination. NY-ESO-1 CD4 and CD8 T-cell responses were elicited in these patients and their epitopes were identified. Using a multifunctional cytokine assay, the number of single or double cytokine-producing cells was increased in NY-ESO-1-specific CD4 and CD8 T cells after vaccination. Multiple cytokine-producing cells were observed in PD-1 (-) and PD-1 (+) CD4 T cells. In conclusion, our study indicated that the NY-ESO-1 OLP vaccine mixed with Picibanil OK-432 and Montanide ISA-51 was well tolerated and elicited NY-ESO-1-specific humoral and CD4 and CD8 T-cell responses in immunized patients.

  10. The new SOXS instrument for the ESO NTT

    CERN Document Server

    Schipani, P; Campana, S; Baruffolo, A; Basa, S; Basso, S; Cappellaro, E; Cascone, E; Cosentino, R; DAlessio, F; De Caprio, V; Della Valle, M; Postigo, A de Ugarte; DOrsi, S; Franzen, R; Fynbo, J; Gal-Yam, A; Gardiol, D; Giro, E; Hamuy, M; Iuzzolino, M; Loreggia, D; Mattila, S; Munari, M; Pignata, G; Riva, M; Savarese, S; Schmidt, B; Scuderi, S; Smartt, S; Vitali, F

    2016-01-01

    SOXS (Son Of X-Shooter) will be a unique spectroscopic facility for the ESO-NTT 3.5-m telescope in La Silla (Chile), able to cover the optical/NIR band (350-1750 nm). The design foresees a high-efficiency spectrograph with a resolution-slit product of ~4,500, capable of simultaneously observing the complete spectral range 350 - 1750 nm with a good sensitivity, with light imaging capabilities in the visible band. This paper outlines the status of the project.

  11. Plans for a fast image recording system at ESO

    Science.gov (United States)

    Grosboel, P. J.

    1984-01-01

    A 256 diode-array will be installed as detector on the ESO OPTRONICS S-3000 measuring machine in order to increase the acquisition rate. A high intensity LED will be used as light source in a pulse mode. The data will be stored on a random access mass storage device as density values for later education. The scanning time for a 30 cm x 30 cm plate with a step size of 10 micron will be less than 10 hours while the dynamic range of the data is expected to be 2.5 density units with an offset of at least 1 unit.

  12. NY-ESO-1 — EDRN Public Portal

    Science.gov (United States)

    NY-ESO-1, official name CTAG1B, is an antigen that is expressed in normal testis and ovary and overexpressed in a wide variety of cancers. The CTAG1B gene is found in a duplicated region of the X-chromosome and therefore has a neighboring gene of identical sequence. CTAG1B is expressed from 18 weeks until birth in human fetal testis. In the adult testis, is strongly expressed in spermatogonia and in primary spermatocytes, but not in post-meiotic cells or in testicular somatic cells (at protein level).

  13. Report on the ''ESO Python Boot Camp — Pilot Version''

    Science.gov (United States)

    Dias, B.; Milli, J.

    2017-03-01

    The Python programming language is becoming very popular within the astronomical community. Python is a high-level language with multiple applications including database management, handling FITS images and tables, statistical analysis, and more advanced topics. Python is a very powerful tool both for astronomical publications and for observatory operations. Since the best way to learn a new programming language is through practice, we therefore organised a two-day hands-on workshop to share expertise among ESO colleagues. We report here the outcome and feedback from this pilot event.

  14. A psf-fitting pipeline for VVV-ESO: The star cluster Pismis 24

    Science.gov (United States)

    Dias, R. A. G.; Bonatto, C.

    2014-10-01

    Este trabalho apresenta um algoritmo para a extração de dados fotométricos do catálogo "VISTA Variables in the Via Láctea" (VVV) do ESO. A principal característica do algoritmo é evitar a interação com o usuário mantendo precisão e profundidade fotométrica, de fato o algoritmo foi capaz de gerar dados mais precisos para as estrelas menos brilhantes (J gtrsim 16, H gtrsim 15,5 e H gtrsim 15) e confiável fotometria para estrelas mais de uma magnitude mais fracas do que as detectáveis com outras técnicas. Embora o algoritmo obtenha resultados menos precisos para as estrelas mais brilhantes, este provou ser o método mais adequado, uma vez que queremos trabalhar com aglomerados abertos jovens, onde a pré-sequência principal é de maior importância. Além disso, podemos combinar 2MASS e VVV para substituir as estrelas saturadas do VVV.

  15. Growth patterns, chemical composition and oxygen consumption in early juvenile Hyas araneus (Decapoda: Majidae) reared in the laboratory

    Science.gov (United States)

    Anger, K.; Harms, J.; Christiansen, M. E.; Süsens, U.; Wilmes, B.

    1992-03-01

    Early (instar I and II) juveniles of the spider crab Hyas araneus were reared under constant conditions (12 °C, 32‰S) in the laboratory, and their growth, biochemical composition, and respiration were studied. Every second day, dry weight (W), ash-free dry weight (AFW), and contents of ash, organic and inorganic carbon (C), nitrogen (N), hydrogen (H), protein, chitin, lipid, and carbohydrates were measured, as well as oxygen consumption. Changes in the absolute amounts of W. AFW, and C, N, and H during the moulting cycle are described with various regression equations as functions of age within a given instar. These patterns of growth differ in part from those that have been observed during previous studies in larval stages of the same and some other decapod species, possibly indicating different growth strategies in larvae and juveniles. There were clear periodic changes in ash (% of W) and inorganic C (as % of total C), with initially very low and then steeply increasing values in postmoult, a maximum in intermoult, and decreasing figures during the premoult phase of each moulting cycle. Similar patterns were observed in the chitin fraction, reaching a maximum of 16% of W (31% of AFW). Ash, inorganic C, and chitin represent the major components of the exoskeleton and hence, changes in their amounts are associated with the formation and loss of cuticle material. Consequently, a high percentage of mineral matter was lost with the exuvia (76% of the late premoult [LPM] ash content, 74% of inorganic C), but relatively small fractions of LPM organic matter (15% of AFW, 11% of organic C, 5 6% of N and H). These cyclic changes in the cuticle caused an inverse pattern of variation in the percentage values (% of W) of AFW, organic C, N, H, and biochemical constituents other than chitin. When these measures of living biomass were related to, exclusively, the organic body fraction (AFM), much less variation was found during individual moulting cycles, with values of

  16. NY-ESO-1 expression in synovial sarcoma and other mesenchymal tumors: significance for NY-ESO-1-based targeted therapy and differential diagnosis.

    Science.gov (United States)

    Lai, Jin-Ping; Robbins, Paul F; Raffeld, Mark; Aung, Phyu Phyu; Tsokos, Maria; Rosenberg, Steven A; Miettinen, Markku M; Lee, Chyi-Chia Richard

    2012-06-01

    A promising targeted therapy against NY-ESO-1 (CTAG 1B) using genetically modified T-cells in synovial sarcomas was recently demonstrated in a clinical trial at the NCI. To investigate the role of NY-ESO-1 immunohistochemistry in patient selection and gain better insight into the incidence of NY-ESO-1 expression in synovial sarcomas and other mesenchymal tumors, we evaluated NY-ESO-1 expression by immunohistochemistry in 417 tumors. This collection of samples included: 50 SS18/SSX1/2 fusion positive synovial sarcomas, 155 gastrointestinal stromal tumors (GIST), 135 other spindle cell sarcomas as well as 77 other sarcomas (chondrosarcoma, osteosarcoma, dedifferentiated liposarcoma, alveolar soft part sarcoma, rhabdomyosarcoma, angiosarcoma, malignant mesothelioma, and Ewing's sarcoma). We report that 76% of synovial sarcomas expressed NY-ESO-1 in a strong and diffuse pattern (2-3+, >50-70% of tumor cells). In contrast, only rare cases of other spindle cell mesenchymal tumor expressed NY-ESO-1 (GIST (2/155), malignant peripheral nerve sheath tumors (1/34), and dermatofibrosarcoma protuberans (2/20)). Individual cases of other sarcomas (angiosarcoma, malignant mesothelioma, chondrosarcoma, osteosarcoma, dedifferentiated liposarcoma, alveolar soft part sarcoma, and Ewing's sarcoma) were positive for NY-ESO-1. However, no positive cases were identified amongst our cohort of leiomyosarcomas (0/24), hemangiopericytoma/solitary fibrous tumors (0/40), and cellular schwannomas (0/17). In summary, we find that NY-ESO-1 is strongly and diffusely expressed in a majority of synovial sarcomas, but only rarely in other mesenchymal lesions. Beyond its role in patient selection for targeted therapy, immunohistochemistry for NY-ESO-1 may be diagnostically useful for the distinction of synovial sarcoma from other spindle cell neoplasms.

  17. ESTUDIO SOBRE PRÁCTICAS DOCENTES EN EVALUACIÓN DE LA LENGUA INGLESA EN LA ESO

    Directory of Open Access Journals (Sweden)

    Fernando D. Rubio

    2012-01-01

    Full Text Available Se critica la enseñanza del inglés en España y los resultados de aprendizaje. En este artículo se advierte que en parte se debe a la ausencia de evaluación oral en la ESO, y para ello se han analizado las prácticas docentes de evaluación. Se recogieron instrumentos de evaluación utilizados, en nuestro caso exámenes, y se analizaron sus contenidos. Los resultados obtenidos indican que las destrezas orales apenas se evalúan, que los elementos comunicativos son casi inexistentes y que no se siguen algunos criterios de evaluación marcados por la ley.

  18. Increased NY-ESO-1 Expression and Reduced Infiltrating CD3+ T Cells in Cutaneous Melanoma

    OpenAIRE

    Mara Giavina-Bianchi; Pedro Giavina-Bianchi; Mirian Nacagami Sotto; Alona Muzikansky; Jorge Kalil; Cyro Festa-Neto; Duncan, Lyn M.

    2015-01-01

    NY-ESO-1 is a cancer-testis antigen aberrantly expressed in melanomas, which may serve as a robust and specific target in immunotherapy. NY-ESO-1 antigen expression, tumor features, and the immune profile of tumor infiltrating lymphocytes were assessed in primary cutaneous melanoma. NY-ESO-1 protein was detected in 20% of invasive melanomas (16/79), rarely in in situ melanoma (1/10) and not in benign nevi (0/20). Marked intratumoral heterogeneity of NY-ESO-1 protein expression was observed. N...

  19. Increased NY-ESO-1 Expression and Reduced Infiltrating CD3+ T Cells in Cutaneous Melanoma

    Directory of Open Access Journals (Sweden)

    Mara Giavina-Bianchi

    2015-01-01

    Full Text Available NY-ESO-1 is a cancer-testis antigen aberrantly expressed in melanomas, which may serve as a robust and specific target in immunotherapy. NY-ESO-1 antigen expression, tumor features, and the immune profile of tumor infiltrating lymphocytes were assessed in primary cutaneous melanoma. NY-ESO-1 protein was detected in 20% of invasive melanomas (16/79, rarely in in situ melanoma (1/10 and not in benign nevi (0/20. Marked intratumoral heterogeneity of NY-ESO-1 protein expression was observed. NY-ESO-1 expression was associated with increased primary tumor thickness (P=0.007 and inversely correlated with superficial spreading melanoma (P<0.02. NY-ESO-1 expression was also associated with reduced numbers and density of CD3+ tumor infiltrating lymphocytes (P=0.017. When NY-ESO-1 protein was expressed, CD3+ T cells were less diffusely infiltrating the tumor and were more often arranged in small clusters (P=0.010 or as isolated cells (P=0.002 than in large clusters of more than five lymphocytes. No correlation of NY-ESO-1 expression with gender, age, tumor site, ulceration, lymph node sentinel status, or survival was observed. NY-ESO-1 expression in melanoma was associated with tumor progression, including increased tumor thickness, and with reduced tumor infiltrating lymphocytes.

  20. NY-ESO-1 protein glycosylated by yeast induces enhanced immune responses.

    Science.gov (United States)

    Wadle, Andreas; Mischo, Axel; Strahl, Sabine; Nishikawa, Hiroyoshi; Held, Gerhard; Neumann, Frank; Wullner, Beate; Fischer, Eliane; Kleber, Sascha; Karbach, Julia; Jager, Elke; Shiku, Hiroshi; Odunsi, Kunle; Shrikant, Protul A; Knuth, Alexander; Cerundolo, Vincenzo; Renner, Christoph

    2010-11-01

    Vaccine strategies that target dendritic cells to elicit potent cellular immunity are the subject of intense research. Here we report that the genetically engineered yeast Saccharomyces cerevisiae, expressing the full-length tumour-associated antigen NY-ESO-1, is a versatile host for protein production. Exposing dendritic cells (DCs) to soluble NY-ESO-1 protein linked to the yeast a-agglutinin 2 protein (Aga2p) protein resulted in protein uptake, processing and MHC class I cross-presentation of NY-ESO-1-derived peptides. The process of antigen uptake and cross-presentation was dependent on the glycosylation pattern of NY-ESO-1-Aga2p protein and the presence of accessible mannose receptors. In addition, NY-ESO-1-Aga2p protein uptake by dendritic cells resulted in recognition by HLA-DP4 NY-ESO-1-specific CD4(+) T cells, indicating MHC class II presentation. Finally, vaccination of mice with yeast-derived NY-ESO-1-Aga2p protein led to an enhanced humoral and cellular immune response, when compared to the bacterially expressed NY-ESO-1 protein. Together, these data demonstrate that yeast-derived full-length NY-ESO-1-Aga2p protein is processed and presented efficiently by MHC class I and II complexes and warrants clinical trials to determine the potential value of S. cerevisiae as a host for cancer vaccine development. Copyright © 2010 John Wiley & Sons, Ltd.

  1. Increased NY-ESO-1 expression and reduced infiltrating CD3+ T cells in cutaneous melanoma.

    Science.gov (United States)

    Giavina-Bianchi, Mara; Giavina-Bianchi, Pedro; Sotto, Mirian Nacagami; Muzikansky, Alona; Kalil, Jorge; Festa-Neto, Cyro; Duncan, Lyn M

    2015-01-01

    NY-ESO-1 is a cancer-testis antigen aberrantly expressed in melanomas, which may serve as a robust and specific target in immunotherapy. NY-ESO-1 antigen expression, tumor features, and the immune profile of tumor infiltrating lymphocytes were assessed in primary cutaneous melanoma. NY-ESO-1 protein was detected in 20% of invasive melanomas (16/79), rarely in in situ melanoma (1/10) and not in benign nevi (0/20). Marked intratumoral heterogeneity of NY-ESO-1 protein expression was observed. NY-ESO-1 expression was associated with increased primary tumor thickness (P = 0.007) and inversely correlated with superficial spreading melanoma (P ESO-1 expression was also associated with reduced numbers and density of CD3+ tumor infiltrating lymphocytes (P = 0.017). When NY-ESO-1 protein was expressed, CD3+ T cells were less diffusely infiltrating the tumor and were more often arranged in small clusters (P = 0.010) or as isolated cells (P = 0.002) than in large clusters of more than five lymphocytes. No correlation of NY-ESO-1 expression with gender, age, tumor site, ulceration, lymph node sentinel status, or survival was observed. NY-ESO-1 expression in melanoma was associated with tumor progression, including increased tumor thickness, and with reduced tumor infiltrating lymphocytes.

  2. TNO Photometry and Spectroscopy at ESO and Calar Alto

    Science.gov (United States)

    Boehnhardt, H.; Sekiguchi, T.; Vair, M.; Hainaut, O.; Delahodde, C.; West, R. M.; Tozzi, G. P.; Barrera, L.; Birkle, K.; Watanabe, J.; Meech, K.

    New photometry and spectroscopy of Transneptunian objects (TNO) has been obtained at ESO (VLT+FORS1, NTT+SOFI) and the Calar Alto (3.5m+MOSCA) observatory. BVRI photometry of more than 10 objects confirms the general colour-colour distribution of TNOs found previously. Quasi-simultaneous spectroscopy in the visible wavelength range of 5 TNOs did not reveal any spectral signature apart from the spetral gradients which are in agreement with the broadband colours. JHK filter photometry of 3 objects indicates that the reddening may only occur in the near-IR at least in some cases. Using new observations from the ESO VLT the lightcurve, colours and spectrum of 1996TO66 are investigated: the rotation period of 6.25h is confirmed, also the change in the lightcurve between 1997 and 1998 which indicates an exceptional behaviour in this object (temporary cometary activity ?). The 1999 photometry and spectroscopy in the visible revealed solar colours, no reddening and no spectral features. V-R colour changes over the rotation phase are not found. This works is done in colaboration with:

  3. ESO 207-61: Its Distance and Very Low Luminosity.

    Science.gov (United States)

    Fredrick, L. W.; Ianna, P. A.

    1992-12-01

    A preliminary trigonometric parallax for the very cool star ESO 207--61 places it at a distance of approximately 16 pc, and confirms its suspected low luminosity. From our parallax and published photometry we estimate its visual absolute magnitude to be 19.47, that is about 0.1 mag fainter than LHS 2924. ESO 207-61 (alpha = 7(h) 06(m) , delta = -48deg 56' [1950]) was identified in a faint proper motion star search program by Ruiz, Takamiya, and Roth (ApJ 367, L59, 1991). Its spectrum resembles that of LHS 2924 (M9). Based on the similarity to LHS 2924 they estimated a distance of 15 pc and a visual absolute magnitude of 19.5. The astrometric data is being acquired at Siding Spring Observatory with the 1 meter reflector and GEC 8603 CCD in the I band. This research is supported by the National Science Foundation, Mount Stromlo and Siding Spring Observatories, and the Estate of Leander J. McCormick.

  4. CERN, ESA and ESO Launch "Physics On Stage"

    Science.gov (United States)

    2000-03-01

    Physics is everywhere . The laws of physics govern the Universe, the Sun, the Earth and even our own lives. In today's rapidly developing society, we are becoming increasingly dependent on high technology - computers, transport, and communication are just some of the key areas that are the result of discoveries by scientists working in physics. But how much do the citizens of Europe really know about physics? Here is a unique opportunity to learn more about this elusive subject! [Go to Physics On Stage Website] Beginning in February 2000, three major European research organisations are organising a unique Europe-wide programme to raise the public awareness of physics and related sciences. "Physics on Stage" is launched by the European Laboratory for Particle Physics (CERN) , the European Space Agency (ESA) and the European Southern Observatory (ESO) , with support from the European Union. Other partners are the European Physical Society (EPS) and the European Association for Astronomy Education (EAAE). This exciting programme is part of the European Week for Science and Technology and will culminate in a Science Festival during November 6-11, 2000, on the CERN premises at the French-Swiss border near Geneva. Why "Physics on Stage"? The primary goal of "Physics on Stage" is to counteract the current decline in interest and knowledge about physics among Europe's citizens by means of a series of highly visible promotional activities. It will bring together leading scientists and educators, government bodies and the media, to confront the diminishing attraction of physics to young people and to develop strategies to reverse this trend. The objective in the short term is to infuse excitement and to provide new educational materials. In the longer term, "Physics on Stage" will generate new developments by enabling experts throughout Europe to meet, exchange and innovate. "Physics on Stage" in 22 European Countries "Physics on Stage" has been initiated in 22 European

  5. Report on the ESO Workshop ''Rainbows on the Southern Sky: Science and Legacy Value of the ESO Public Surveys and Large Programmes''

    Science.gov (United States)

    Arnaboldi, M.; Rejkuba, M.; Leibundgut, B.; Beccari, G.

    2015-12-01

    This was the third ESO workshop on the science from Large Programmes and the second on Public Surveys. By design, this workshop covered all areas of research in observational astronomy, providing a forum for the presentation of the most recent scientific results from these programmes and fostering discussions on the planned developments enabled by large and coherent time allocations on ESO telescopes. Several aspects of the legacy value of such programmes —technological, archival content, access to data, time domain and sociological — were evaluated and set a reference for future developments of ESO services to the community.

  6. Application of serum NY-ESO-1 antibody assay for early SCLC diagnosis.

    Science.gov (United States)

    Yang, Jihua; Jiao, Shunchang; Kang, Jingbo; Li, Rong; Zhang, Guanzhong

    2015-01-01

    NY-ESO-1 antibody is one of the cancer-related antibodies. The purpose of this study was to investigate the diagnostic role of the NY-ESO-1 humoral immune response in small cell lung cancer (SCLC). We recombined the recombinant protein of NY-ESO-1 antibody and NSE, analyzed them by Enzyme-linked immunosorbent assay, and then established the Receiver Operating Characteristic (ROC) curve to estimate the diagnostic value of NY-ESO-1 antibody, NSE and their combinations. According to detection, the positive rate of NY-ESO-1 humoral immune response (26.3%), NSE (43.8%) and their combinations (10.5%) were all lower than the negative rate which indicated that the NY-ESO-1 antibody might be down-regulated in SCLC. And the positive rate wasn't related to clinicopathologic characteristics. The ROC curve demonstrated that with a 37.17% sensitivity and a 91.7% specificity along with a AUC of 0.619 for NY-ESO-1ab as well as with a 48.3% sensitivity and a 90.87% specificity along with a AUC value of 0.773 for NSE, their diagnostic value were both high. Besides, the diagnostic value of their combinations was also good for a AUC of 0.83 and a 69.12% sensitivity and a 91.8% specificity. There were significant difference of diagnostic value among three types above (NY-ESO-1 vs. NSE, P ESO-1, P ESO-1ab, NSE and their combinations all were important diagnostic markers for SCLC. Moreover, the diagnostic value of their combinations was higher than any single of them. And NY-ESO-1 humoral immune to NSE might be a potential diagnostic indicator in SCLC.

  7. NY-ESO-1抗原与肿瘤免疫治疗进展%NY-ESO-1 and Cancer Immunotherapy

    Institute of Scientific and Technical Information of China (English)

    彭吉润; 冷希圣

    2008-01-01

    NY-ESO-1抗原是肿瘤-睾丸抗原家族中的重要成员,在多种类型的肿瘤中广泛表达,并且是迄今发现的最具免疫原性的肿瘤抗原,可以在NY-ESO-1表达阳性的肿瘤患者体内引起自发性体液免疫反应和特异性T细胞免疫反应.因此,NY-ESO-1被认为是最好的肿瘤候选疫苗,在肿瘤免疫治疗中最具发展潜力.本文主要介绍了近年来有关NY-ESO-1抗原以及相关疫苗的研究进展.

  8. Progress in NY-ESO-I as cancer vaccines%NY-ESO-1癌症疫苗研究进展

    Institute of Scientific and Technical Information of China (English)

    刘志青

    2006-01-01

    NY-ESO-1抗原是近年来发现的一种肿瘤特异性抗原,在乳腺癌、黑色素瘤、食管癌等20多种肿瘤中均有不同程度的表达.NY-ESO-1的广泛表达使其成为多种实体瘤特异性疫苗免疫治疗的首选抗原.在制备NY-ESO-1癌症疫苗时,目前主要围绕癌症疫苗的类型、抗原的加工提呈两个方面进行研究.现综述近年来NY-ESO-1癌症疫苗在这两方面的研究进展.

  9. Induction of immune response against NY-ESO-1 by CHP-NY-ESO-1 vaccination and immune regulation in a melanoma patient.

    Science.gov (United States)

    Tsuji, Kazuhide; Hamada, Toshitada; Uenaka, Akiko; Wada, Hisashi; Sato, Eiichi; Isobe, Midori; Asagoe, Kenji; Yamasaki, Osamu; Shiku, Hiroshi; Ritter, Gerd; Murphy, Roger; Hoffman, Eric W; Old, Lloyd J; Nakayama, Eiichi; Iwatsuki, Keiji

    2008-10-01

    NY-ESO-1 is a cancer/testis antigen highly immunogenic in cancer patients. Cholesterol-bearing hydrophobized pullulan (CHP) is a nanoparticle-forming antigen-delivery vehicle and CHP complexed with NY-ESO-1 protein (CHP-NY-ESO-1) efficiently activates CD4 and CD8 T cells in vitro. In this study we report on a 50-year-old male melanoma patient with multiple skin and organ metastases (T4N3M1c) who was vaccinated with CHP-NY-ESO-1 at biweekly intervals and who had an unusual disease course. We characterized in this patient humoral and cellular immune responses, immune regulatory cells, and cytokine profiles in the peripheral blood and at local tumor sites. Ten days after the second CHP-NY-ESO-1 vaccination (day 25), blisters appeared on the skin at the metastatic lesions associated with inflammatory changes. A skin biopsy showed the presence of many NY-ESO-1-expressing apoptotic melanoma cells as determined by a terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end labeling (TUNEL) test. However, the tumors continued to grow, and the patient died of pulmonary failure due to multiple metastases on day 48. Serum antibody responses were detected after the second CHP-NY-ESO-1 vaccination and antibody titer increased with subsequent vaccinations. Th1 dependent IgG1 was the predominant immunoglobulin subtype. Both, NY-ESO-1-specific CD4 and CD8 T cell responses were detected in PBMC by IFN-gamma secretion assays. After CHP-NY-ESO-1 vaccination a slight decrease in CD4(+)CD25(+)Foxp3(+) Tregs was observed in PBMC but significantly increased numbers of CD4(+)CD25(+)Foxp3(+) Tregs and CD68(+) immunoregulatory macrophages were detected at the local tumor sites. CD4(+)CD25(+)Foxp3(+) Tregs were also increased in the blister fluid. Cytokines in the serum suggested a polarization towards a Th1 pattern in the PBMC and those in the blister fluid suggested a Th2-type response at the tumor site. Our observations indicate induction of specific humoral and

  10. Mechanical thrombectomy in acute ischemic stroke: Consensus statement by ESO-Karolinska Stroke Update 2014/2015, supported by ESO, ESMINT, ESNR and EAN

    OpenAIRE

    Wahlgren, N; Moreira, T.; Michel, P.; Steiner, T.; Jansen, O; Cognard, C; Mattle, H P; van Zwam, W.; Holmin, S.; Tatlisumak, T.; Petersson, J; Caso, V.; Hacke, W; Mazighi, M.; Arnold, M.

    2016-01-01

    The original version of this consensus statement on mechanical thrombectomy was approved at the European Stroke Organisation (ESO)-Karolinska Stroke Update conference in Stockholm, 16–18 November 2014. The statement has later, during 2015, been updated with new clinical trials data in accordance with a decision made at the conference. Revisions have been made at a face-to-face meeting during the ESO Winter School in Berne in February, through email exchanges and the final version has then bee...

  11. VizieR Online Data Catalog: RR Lyrae variables in ESO294-G010 and ESO410-G005 (Yang+, 2014)

    Science.gov (United States)

    Yang, S.-C.; Wagner-Kaiser, R.; Sarajedini, A.; Kim, S. C.; Kyeong, J.

    2016-08-01

    The science images of ESO294-G010 and ESO410-G005 used in this study were taken with the Advanced Camera for Surveys Wide Field Channel (ACS/WFC) on board Hubble Space Telescope (HST) as a part of GO-10503 (PI: Da Costa). ESO294-G010 (R.A.=00:26:33.40 (J2000), Decl.=-41:51:19.0 (J2000)) was observed on the HJD (+2453000) range 859.27358-861.13659 with the F606W filter, and on the HJD (+2453000) range 859.40613-861.00342 with the F814W filter. ESO410-G005 (R.A.=00:15:31.40 (J2000), Decl.=-32:10:47.0 (J2000)) was observed on the HJD (+2453000) range 861.40425-863.21702 with the F606W filter, and on the HJD (+2453000) range 861.53711-866.08158 with the filter F814W. The central regions of each galaxy were placed on one of WFC chips so that the imaging covers almost the entire visual extent of the targets. ESO294-G010 was imaged 12 times in the F606W and 24 times in the F814W filter with an exposure time of 1160s during the observing baseline of ~1.86days. The same number of exposures were obtained for the observations of ESO410-G005 with an exposure time of 1120s over the observing baseline of 4.55days. The basic properties of each of these RRL candidates are summarized in Tables 2 and 3. We have also uncovered a significant number of Luminous Variable (LV) candidates in both transition-type dwarf galaxies (22 in ESO294-G010; 19 in ESO410-G005). Their photometric and pulsation properties are summarized in Table4. (4 data files).

  12. ESO 113-IG45 galaxy and/or quasar?

    CERN Document Server

    West, R M; Danks, A C

    1978-01-01

    Spectroscopy, UBV photometry and photography have been obtained of the extraordinary 13th magnitude object ESO 113-IG45 identified as a Seyfert galaxy by Fairall (1977); R.A.=01/sup h/ 21/sup m/.9; Decl .=-59 degrees 04' (1950). V/sub 0/=13630+or-50 km s/sup -1/; M/sub V /=-24/sup m/.0; largest diameter 75 kpc or more (with H/sub 0/=55 km s /sup -1/ Mpc/sup -1/). The nucleus is stellar-like and several times more luminous than the surrounding envelope which has a well-developed lane-structure. It is the intrinsically most luminous Seyfert nuclear yet known, and may be described as a 'quasar in the center of a (spiral) galaxy'. It is probably associated with the X-ray source 2A0120-591. (14 refs).

  13. New BVRI photometry results on KBOs from the ESO VLT

    CERN Document Server

    Santos-Sanz, P; Barrera, L; Boehnhardt, H

    2008-01-01

    Photometric surveys of transNeptunian objects (TNOs) and Centaurs have suggested possible correlations between some orbital parameters and surface colors of classical objects, scattered disk objects (SDOs), and Centaurs. However, larger sample sizes are needed in order to corroborate or rule out the possible correlations and find some possible new ones. We use VLT-FORS images through BVRI filters of 32 Kuiper Belt Objects (KBOs) and obtain their colors after proper reduction and calibration. We study the possible correlations merging these new measurements with the VLT published results from the ESO large program and with the latest published results of the Meudon Multicolor Survey via non-parametric statistical tests. We obtain a large dataset of 116 objects (classical, SDOs and Centaurs) and, in addition to confirming most of the correlations and conclusions reached in the literature, some possible new correlations are found. The most interesting ones are some correlations of color vs. orbital parameters fo...

  14. Epigenetic potentiation of NY-ESO-1 vaccine therapy in human ovarian cancer.

    Science.gov (United States)

    Odunsi, Kunle; Matsuzaki, Junko; James, Smitha R; Mhawech-Fauceglia, Paulette; Tsuji, Takemasa; Miller, Austin; Zhang, Wa; Akers, Stacey N; Griffiths, Elizabeth A; Miliotto, Anthony; Beck, Amy; Batt, Carl A; Ritter, Gerd; Lele, Shashikant; Gnjatic, Sacha; Karpf, Adam R

    2014-01-01

    The cancer-testis/cancer-germline antigen NY-ESO-1 is a vaccine target in epithelial ovarian cancer (EOC), but its limited expression is a barrier to vaccine efficacy. As NY-ESO-1 is regulated by DNA methylation, we hypothesized that DNA methyltransferase (DNMT) inhibitors may augment NY-ESO-1 vaccine therapy. In agreement, global DNA hypomethylation in EOC was associated with the presence of circulating antibodies to NY-ESO-1. Pre-clinical studies using EOC cell lines showed that decitabine treatment enhanced both NY-ESO-1 expression and NY-ESO-1-specific CTL-mediated responses. Based on these observations, we performed a phase I dose-escalation trial of decitabine, as an addition to NY-ESO-1 vaccine and doxorubicin liposome (doxorubicin) chemotherapy, in 12 patients with relapsed EOC. The regimen was safe, with limited and clinically manageable toxicities. Both global and promoter-specific DNA hypomethylation occurred in blood and circulating DNAs, the latter of which may reflect tumor cell responses. Increased NY-ESO-1 serum antibodies and T cell responses were observed in the majority of patients, and antibody spreading to additional tumor antigens was also observed. Finally, disease stabilization or partial clinical response occurred in 6/10 evaluable patients. Based on these encouraging results, evaluation of similar combinatorial chemo-immunotherapy regimens in EOC and other tumor types is warranted.

  15. Expression and immunogenicity of NY-ESO-1 in colorectal cancer.

    Science.gov (United States)

    Li, Ya; Song, Ruifeng; Li, Xinqiang; Xu, Feng

    2017-06-01

    Serum assays of NY-ESO-1 antibodies provide a guide to discriminate between patients who suffer from different types of cancer. In the present study, the expression of NY-ESO-1 was detected with the aim to identify a novel tumor antigen in colorectal cancer (CRC). Sera were obtained from 89 healthy individuals and 236 patients with CRC with stage I, II, III and IV tumors. The NY-ESO-1 autoantibody levels were determined using an enzyme-linked immunosorbent assay. The mRNA and protein expression levels of NY-ESO-1 were detected using reverse transcription-polymerase chain reaction and immunohistochemistry, respectively, in 60 CRC and paired adjacent non-tumor tissues. NY-ESO-1 antibody was detected in 40 of the 236 (16.9%) patients with CRC. The NY-ESO-1 antibody combined with carcinoembryonic antigen enhanced the sensitivity, from 52.1 to 62.7%, of the diagnosis of CRC. The frequency of antibody positivity increased with the TNM cancer stage (8.8 vs. 28.3% in stages I+II and III+IV, respectively). The mRNA and protein expression levels of NY-ESO-1 were significantly higher in CRC tissue than in adjacent non-tumor tissue. In conclusion, NY-ESO-1 is frequently expressed in CRC with the capacity of inducing a humoral immune response in CRC patients, exhibiting the potential to be a promising biomarker for CRC.

  16. A deep X-ray spectroscopic survey of the ESO imaging survey fields

    DEFF Research Database (Denmark)

    Nørgaard-Nielsen, Hans Ulrik; Jørgensen, H.E.; Hansen, Lene

    1998-01-01

    V, we propose to perform a spectroscopic survey with SODART and push these telescopes to the limit at the high energies. By selecting the four ESO Imaging Survey fields EIS teach 6 deg(2)) we will take full advantage of the large, systematic effort ESO is putting into the optical survey of these fields...

  17. NY-ESO-1-specific immunological pressure and escape in a patient with metastatic melanoma.

    Science.gov (United States)

    von Boehmer, Lotta; Mattle, Muriel; Bode, Peter; Landshammer, Alexandro; Schäfer, Carolin; Nuber, Natko; Ritter, Gerd; Old, Lloyd; Moch, Holger; Schäfer, Niklaus; Jäger, Elke; Knuth, Alexander; van den Broek, Maries

    2013-01-01

    During cancer progression, malignant cells may evade immunosurveillance. However, evidence for immunological escape in humans is scarce. We report here the clinical course of a melanoma patient whose initial tumor was positive for the antigens NY-ESO-1, MAGE-C1, and Melan-A. Upon immunization with a recombinant vaccinia/fowlpox NY-ESO-1 construct, the patient experienced a mixed clinical response and spreading of the NY-ESO-1 epitopes in the CD4+ T cell compartment. After NY-ESO-1 protein + CpG immunization, the patient's anti-NY-ESO-1 IgG response increased. Over the following years, progressing lesions were resected and found to be NY-ESO-1-negative while being positive for MAGE-C1, Melan-A, and MHC-I. The fatal, inoperable brain metastasis was analyzed after his death and also proved to be NY-ESO-1-negative, while being positive for MAGE-C1 and Melan-A, as well as MHC-I. We propose that cancer control and cancer escape in this patient were governed by NY-ESO-1-specific immunological pressure. Our findings provide evidence for the existence of immunoediting and immunoescape in this cancer patient.

  18. Publication of science data products through the ESO archive: lessons learned and future evolution

    Science.gov (United States)

    Retzlaff, Jörg; Arnaboldi, Magda; Delmotte, Nausicaa A. R.; Mascetti, Laura; Micol, Alberto

    2016-07-01

    Phase 3 denotes the process of preparation, submission, validation and ingestion of science data products for storage in the ESO Science Archive Facility and subsequent publication to the scientific community. In this paper we will review more than four years of Phase 3 operations at ESO and we will discuss the future evolution of the Phase 3 system.

  19. VizieR Online Data Catalog: Surface Photometry of ESO-Uppsala Galaxies (Lauberts+ 1989)

    NARCIS (Netherlands)

    Lauberts, A.; Valentijn, E. A.

    2006-01-01

    The 15467 southern galaxies in this catalog were scanned from 407 blue and 407 red original ESO-Schmidt plates using a PDS microdensitometer. The galaxies were selected from the ESO-Uppsala Catalogue (VII/34). The original selection criterion was a minimum visual angular diameter of 1arcmin. The pla

  20. Antibody responses to NY-ESO-1 in primary breast cancer identify a subtype target for immunotherapy.

    Science.gov (United States)

    Hamaï, Ahmed; Duperrier-Amouriaux, Karine; Pignon, Pascale; Raimbaud, Isabelle; Memeo, Lorenzo; Colarossi, Cristina; Canzonieri, Vincenzo; Perin, Tiziana; Classe, Jean-Marc; Campone, Mario; Jézéquel, Pascal; Campion, Loïc; Ayyoub, Maha; Valmori, Danila

    2011-01-01

    The highly immunogenic human tumor antigen NY-ESO-1 (ESO) is a target of choice for anti-cancer immune therapy. In this study, we assessed spontaneous antibody (Ab) responses to ESO in a large cohort of patients with primary breast cancer (BC) and addressed the correlation between the presence of anti-ESO Ab, the expression of ESO in the tumors and their characteristics. We found detectable Ab responses to ESO in 1% of the patients. Tumors from patients with circulating Ab to ESO exhibited common characteristics, being mainly hormone receptor (HR)⁻ invasive ductal carcinomas of high grade, including both HER2⁻ and HER2⁺ tumors. In line with these results, we detected ESO expression in 20% of primary HR⁻ BC, including both ESO Ab⁺ and Ab⁻ patients, but not in HR⁺ BC. Interestingly, whereas expression levels in ESO⁺ BC were not significantly different between ESO Ab⁺ and Ab⁻ patients, the former had, in average, significantly higher numbers of tumor-infiltrated lymph nodes, indicating that lymph node invasion may be required for the development of spontaneous anti-tumor immune responses. Thus, the presence of ESO Ab identifies a tumor subtype of HR⁻ (HER2⁻ or HER2⁺) primary BC with frequent ESO expression and, together with the assessment of antigen expression in the tumor, may be instrumental for the selection of patients for whom ESO-based immunotherapy may complement standard therapy.

  1. 肿瘤抗原NY-ESO-1研究进展

    Institute of Scientific and Technical Information of China (English)

    王运伟; 顾琴龙; 朱正纲

    2005-01-01

    肿瘤抗原NY-ESO-1是肿瘤-睾丸(cancer-testis,CT)抗原,其编码基因是一基因家族,目前发现的主要包括NY-ESO-1、LAGE-1和ESO3三个成员.NY-ESO-1是迄今发现的最具免疫原性的肿瘤抗原之一,可以在NY-ESO-1表达阳性的肿瘤患者体内引起自发性体液免疫反应和T细胞免疫反应,因此在抗原特异性肿瘤免疫治疗中具有广泛的应用前景.

  2. NY-ESO-1 expression is tightly linked to TMPRSS2-ERG fusion in prostate cancer.

    Science.gov (United States)

    Grupp, Katharina; Ospina-Klinck, Daniel; Tsourlakis, Maria Christina; Koop, Christina; Wilczak, Waldemar; Adam, Meike; Simon, Ronald; Sauter, Guido; Izbicki, Jakob Robert; Graefen, Markus; Huland, Hartwig; Steurer, Stefan; Schlomm, Thorsten; Minner, Sarah; Quaas, Alexander

    2014-07-01

    NY-ESO-1 has been suggested as therapeutic cancer vaccine in prostate cancer. This study was undertaken to explore the relationship of NY-ESO-1 with tumor phenotype, biochemical recurrence, and molecular subgroups in hormone-naive prostate cancers. NY-ESO-1 immunohistochemistry was analyzed on a tissue microarray containing 11,152 prostate cancer samples. Results were compared to clinically follow-up data, ERG status, and deletions on PTEN, 3p13, 5q21, and 6q15. NY-ESO-1 expression was absent in benign prostate glands. In prostate cancer, NY-ESO-1 positivity was found 8.8% of our 8,761 interpretable tumors including 5.8% with weak, 2.5% with moderate, and 0.5% with strong expression. There was a threefold higher rate of NY-ESO-1 expression in ERG fusion positive tumors than in ERG negative cancers (P ESO-1 expression was associated with early biochemical recurrence (P = 0.0002) and high Gleason grade (P ESO-1 expression was also linked to PTEN (P = 0.0012) and 6q15 deletions (P = 0.0005). Our observations indicate a tight link of NY-ESO-1 expression to ERG activation and (to a lesser extent) PTEN- and 6q15-deletions in prostate cancer. The impact of these interactions on the likelihood of response to immunotherapy is unclear. The prognostic impact of NY-ESO-1 expression is little and not independent of histologic variables. © 2014 Wiley Periodicals, Inc.

  3. New Method for Data Treatment Developed at ESO

    Science.gov (United States)

    1996-08-01

    How Future Astronomical Observations Will be Done The past four centuries have seen dramatic improvements in astronomical equipment, in terms of better and larger telescopes, more accurate and sensitive detectors and, not the least, by advanced space instruments with access to new spectral regions. However, until recently there has been little progress on another equally important front, that of quantifying the unavoidable influence of this equipment on the astronomical data they produce . For a long time, astronomers have desired to remove efficiently these `instrumental effects' from their data, in order to give them a clearer understanding of the objects in the Universe and their properties. But it is only now that this fundamental problem can finally be tackled efficiently, with the advent of digital imaging techniques and powerful computers. Two researchers at the ESO Headquarters, Michael R. Rosa of the Space Telescope European Co-ordinating Facility (ST/ECF [1]) and Pascal Ballester of the Data Management Division (DMD) are now developing a new approach to this age-old problem. These results are important for the future use of the ESO Very Large Telescope (VLT) , the Hubble Space Telescope (HST) and other large facilities as well [2]. The observational process Observations are crucial to the progress of all natural sciences, including astronomy. Nevertheless, the properties of the observed objects are rarely revealed directly. First, observational data are gathered at the telescopes with instruments such as cameras and spectrophotometers. Then these `raw' data are processed with advanced computer programmes to produce scientifically meaningful data which are finally scrutinized by the astronomers in order to learn more about the observed celestial objects. A basic problem in this chain is the influence of the telescopes and instruments on the data they produce. The `raw' observational data carries the marks, not only of the celestial objects that are

  4. Multiperiodicity, modulations and flip-flops in variable star light curves III. Carrier fit analysis of LQ Hya photometry for 1982-2014

    CERN Document Server

    Olspert, Nigul; Pelt, Jaan; Cole, Elizabeth M; Hackman, Thomas; Lehtinen, Jyri; Henry, Gregory W

    2014-01-01

    We study LQ Hya photometry for 1982-2014 with the carrier fit (CF) -method and compare our results to earlier photometric analysis and recent Doppler imaging maps. We first utilize different types of statistical methods to estimate various candidates for the carrier period for the CF method. Secondly, a global fit to the whole data set and local fits to shorter segments are computed with the period that is found to be the optimal one. The harmonic least-squares analysis of all the available data reveals a short period close to 1.6 days as a limiting value for a set of significant frequencies. We interpret this as the rotation period of the spots near the equatorial region. In addition, the distribution of the significant periods is found to be bimodal, hinting of a longer-term modulating period, which we set out to study with a two-harmonic CF model. Weak modulation signal is, indeed retrieved, with a period of roughly 6.9 years. The phase dispersion analysis gives a clear symmetric minimum for coherence time...

  5. NY-ESO-1 expression in hepatocellular carcinoma: A potential new marker for early recurrence after surgery.

    Science.gov (United States)

    Xu, Heng; Gu, Na; Liu, Zhao-Bo; Zheng, Min; Xiong, Fang; Wang, Si-Ying; Li, Ning; Lu, Jun

    2012-01-01

    NY-ESO-1 belongs to the cancer testis antigens (CTA) family, and is identified in a variety of tumors. Certain studies have demonstrated that NY-ESO-1 predicts tumor recurrence and treatment response. No reports are currently available regarding the correlation between NY-ESO-1 and the recurrence of hepatocellular carcinoma (HCC) following surgery. The purpose of the present study was to evaluate the association between NY-ESO-1 and relapse of HCC and to explore the possible mechanisms for this correlation. A total of 120 HCC patients were analyzed for the expression of NY-ESO-1 by immunohistochemistry (IHC). A stable NY-ESO-1 over-expressed HepG2 cell line (ESO-HepG2) was established to determine the biological effects of NY-ESO-1 on cell proliferation, cell cycle and migration by using the xCELLigence DP system, flow cytometry and xCELLigence SP system. NY-ESO-1 was positive in 28 of 120 (23.3%) HCC tumor tissues. NY-ESO-1 was not detectable in adjacent normal liver tissues. A close correlation was found between NY-ESO-1 expression and the recurrence of HCC following surgery (P=0.007). Kaplan-Meier analysis showed a shorter recurrence-free survival (RFS) for patients positive for NY-ESO-1 (log-rank test, P=0.003). The Cox regression model demonstrated that NY-ESO-1 expression was a significant independent predictor for the recurrence of HCC following curative surgery (P=0.022). Compared with HepG2 cells, ESO-HepG2 cells have increased migration but not proliferation ability. In conclusion, NY-ESO-1 expression is associated with worse HCC outcome following surgery, and the mechanism for this finding may be that NY-ESO-1 increases tumor cell migration.

  6. VizieR Online Data Catalog: KiDS-ESO-DR3 multi-band source catalog (de Jong+, 2017)

    NARCIS (Netherlands)

    de Jong, J. T. A.; Verdoes Kleijn, G. A.; Erben, T.; Hildebrandt, H.; Kuijken, K.; Sikkema, G.; Brescia, M.; Bilicki, M.; Napolitano, N. R.; Amaro, V.; Begeman, K. G.; Boxhoorn, D. R.; Buddelmeijer, H.; Cavuoti, S.; Getman, F.; Grado, A.; Helmich, E.; Huang, Z.; Irisarri, N.; La Barbera, F.; Longo, G.; McFarland, J. P.; Nakajima, R.; Paolillo, M.; Puddu, E.; Radovich, M.; Rifatto, A.; Tortora, C; Valentijn, E. A.; Vellucci, C.; Vriend, W-J.; Amon, A.; Blake, C.; Choi, A.; Fenech Conti, I.; Herbonnet, R.; Heymans, C.; Hoekstra, H.; Klaes, D.; Merten, J.; Miller, L.; Schneider, P.; Viola, M.

    2017-01-01

    KiDS-ESO-DR3 contains a multi-band source catalogue encompassing all publicly released tiles, a total of 440 survey tiles including the coadded images, weight maps, masks and source lists of 292 survey tiles of KiDS-ESO-DR3, adding to the 148 tiles released previously (50 in KiDS-ESO-DR1 and 98 in

  7. T cells targeting NY-ESO-1 demonstrate efficacy against disseminated neuroblastoma.

    Science.gov (United States)

    Singh, Nathan; Kulikovskaya, Irina; Barrett, David M; Binder-Scholl, Gwendolyn; Jakobsen, Bent; Martinez, Daniel; Pawel, Bruce; June, Carl H; Kalos, Michael D; Grupp, Stephan A

    The cancer-testis antigen NY-ESO-1 is expressed by many solid tumors and has limited expression by mature somatic tissues, making it a highly attractive target for tumor immunotherapy. Targeting NY-ESO-1 using engineered T cells has demonstrated clinical efficacy in the treatment of some adult tumors. Neuroblastoma is a significant cause of cancer mortality in children, and is a tumor type shown to be responsive to immunotherapies. We evaluated a large panel of primarily resected neuroblastoma samples and demonstrated that 23% express NY-ESO-1. After confirming antigen-specific activity of T cells genetically engineered to express an NY-ESO-1 directed high-affinity transgenic T cell receptor in vitro, we performed xenograft mouse studies assessing the efficacy of NY-ESO-1-targeted T cells in both localized and disseminated models of neuroblastoma. Disease responses were monitored by tumor volume measurement and in vivo bioluminescence. After delivery of NY-ESO-1 transgenic TCR T cells, we observed significant delay of tumor progression in mice bearing localized and disseminated neuroblastoma, as well as enhanced animal survival. These data demonstrate that NY-ESO-1 is an antigen target in neuroblastoma and that targeted T cells represent a potential therapeutic option for patients with neuroblastoma.

  8. Expression of MAGE-A and NY-ESO-1 in Primary and Metastatic Cancers.

    Science.gov (United States)

    Park, Tristen S; Groh, Eric M; Patel, Krishna; Kerkar, Sid P; Lee, Chyi-Chia Richard; Rosenberg, Steven A

    2016-01-01

    Melanoma-associated antigen-A (MAGE-A) and New York esophageal squamous cell cancer-1 (NY-ESO-1) are 2 cancer testis antigens (CTA) demonstrating potential for use in targeted immunotherapy. Clinical trials in melanoma and synovial sarcomas targeting these antigens in immune-based therapies have demonstrated durable tumor regression. Although protein expression of NY-ESO-1 has been assessed in a variety of cancer types, the expression of MAGE-A has not been studied in depth. In this study we analyzed MAGE-A and NY-ESO-1 expression in 314 melanoma specimens from 301 melanoma patients, 38 patients with squamous cell cancers and 111 patients with adenocarcinomas. Our results demonstrated higher expression of MAGE-A compared with NY-ESO-1 in melanomas (32% vs. 13%) and squamous cell carcinomas (45% vs. 7.9%), and higher expression of both CTAs in metastatic versus primary tumors. CTA expression in adenocarcinomas was low (MAGE-A: 10%, NY-ESO-1: 0.9%). In addition, we looked at concordance of expression among metastatic melanoma lesions within the same patient and found concordant expression in 38 of 47 patients for MAGE-A and 43 of 47 patients for NY-ESO-1. Our study demonstrated that the MAGE-A family may be of greater utility than NY-ESO-1 for targeted immunotherapy in a variety of cancer histologies, in particular metastatic melanomas and squamous cell carcinomas.

  9. Expression of NY-ESO-1 gene in human hepatocellular carcinoma%人类NY-ESO-1基因编码在肝癌中的表达

    Institute of Scientific and Technical Information of China (English)

    张阳德; 任菲; 彭健

    2013-01-01

    目的 研究NY-ESO-1在肝细胞肝癌中的表达情况并探索其表达与肝癌预后的相关性.方法 我们收集了124例肝癌患者的肝癌组织和相应的癌旁组织,37例肝硬化患者的肝组织,以及43例非肝硬化的肝组织.应用实时荧光定量聚合酶链技术(RT-PCR)检测了上述组织中NY-ESO-1基因的表达水平,并利用DNA免疫杂交技术和测序技术检测RT-PCR产物.收集健康志愿者外周血基因组DNA作为正常对照.结果 在124例肝癌组织中,56例(45.2%)检测到有NY-ESO-1基因的表达,而在癌旁组织中未检测到表达.NY-ESO-1基因的RT-PCR产物长度为329 bp,利用测序方法检测NY-ESO-1基因突变.在56例表达NY-ESO-1的肝癌组织中,有4例检测到位点2的突变.该突变导致一个氨基酸的变异,这种氨基酸的变异对蛋白结构和功能具有决定性的影响.NY-ESO-1基因的表达与临床特征如肿瘤标志物(甲胎蛋白,半乳糖酸苷酶)、转移、复发和肿瘤的大小无显著关联性.结论 NY-ESO-1在肝癌组织中呈高表达,但是与预后无相关性.NY-ESO-1蛋白能否作为肝癌治疗的候选疫苗有待进一步研究.

  10. A novel human-derived antibody against NY-ESO-1 improves the efficacy of chemotherapy.

    Science.gov (United States)

    Gupta, Anurag; Nuber, Natko; Esslinger, Christoph; Wittenbrink, Mareike; Treder, Martin; Landshammer, Alexandro; Noguchi, Takuro; Kelly, Marcus; Gnjatic, Sacha; Ritter, Erika; von Boehmer, Lotta; Nishikawa, Hiroyoshi; Shiku, Hiroshi; Old, Lloyd; Ritter, Gerd; Knuth, Alexander; van den Broek, Maries

    2013-01-01

    We investigated whether antibodies against intracellular tumor-associated antigens support tumor-specific immunity when administered together with a treatment that destroys the tumor. We propose that released antigens form immune complexes with the antibodies, which are then efficiently taken up by dendritic cells. We cloned the first human monoclonal antibodies against the Cancer/Testis (CT) antigen, NY-ESO-1. We tested whether the monoclonal anti-NY-ESO-1 antibody (12D7) facilitates cross-presentation of a NY-ESO-1-derived epitope by dendritic cells to human CD8+ T cells, and whether this results in the maturation of dendritic cells in vitro. We investigated the efficacy of 12D7 in combination with chemotherapy using BALB/c mice bearing syngeneic CT26 tumors that express intracellular NY-ESO-1. Human dendritic cells that were incubated with NY-ESO-1:12D7 immune complexes efficiently stimulated NY-ESO-1(157-165)/HLA-A2-specific human CD8+ T cells to produce interferon-γ, whereas NY-ESO-1 alone did not. Furthermore, the incubation of dendritic cells with NY-ESO-1:12D7 immune complexes resulted in the maturation of dendritic cells. Treatment of BALB/c mice that bear CT26/NY-ESO-1 tumors with 5-fluorouracil (5-FU) plus 12D7 was significantly more effective than chemotherapy alone. We propose systemic injection of monoclonal antibodies (mAbs) against tumor-associated antigens plus a treatment that promotes the local release of those antigens resulting in immune complex formation as a novel therapeutic modality for cancer.

  11. Mechanical thrombectomy in acute ischemic stroke: Consensus statement by ESO-Karolinska Stroke Update 2014/2015, supported by ESO, ESMINT, ESNR and EAN.

    Science.gov (United States)

    Wahlgren, Nils; Moreira, Tiago; Michel, Patrik; Steiner, Thorsten; Jansen, Olav; Cognard, Christophe; Mattle, Heinrich P; van Zwam, Wim; Holmin, Staffan; Tatlisumak, Turgut; Petersson, Jesper; Caso, Valeria; Hacke, Werner; Mazighi, Mikael; Arnold, Marcel; Fischer, Urs; Szikora, Istvan; Pierot, Laurent; Fiehler, Jens; Gralla, Jan; Fazekas, Franz; Lees, Kennedy R

    2016-01-01

    The original version of this consensus statement on mechanical thrombectomy was approved at the European Stroke Organisation (ESO)-Karolinska Stroke Update conference in Stockholm, 16-18 November 2014. The statement has later, during 2015, been updated with new clinical trials data in accordance with a decision made at the conference. Revisions have been made at a face-to-face meeting during the ESO Winter School in Berne in February, through email exchanges and the final version has then been approved by each society. The recommendations are identical to the original version with evidence level upgraded by 20 February 2015 and confirmed by 15 May 2015. The purpose of the ESO-Karolinska Stroke Update meetings is to provide updates on recent stroke therapy research and to discuss how the results may be implemented into clinical routine. Selected topics are discussed at consensus sessions, for which a consensus statement is prepared and discussed by the participants at the meeting. The statements are advisory to the ESO guidelines committee. This consensus statement includes recommendations on mechanical thrombectomy after acute stroke. The statement is supported by ESO, European Society of Minimally Invasive Neurological Therapy (ESMINT), European Society of Neuroradiology (ESNR), and European Academy of Neurology (EAN). © 2016 World Stroke Organization.

  12. Recommendations from the ESO-Karolinska Stroke Update Conference, Stockholm 13–15 November 2016

    DEFF Research Database (Denmark)

    2017-01-01

    About the meeting: The purpose of the European Stroke Organisation (ESO)-Karolinska Stroke Update Conference is to provide updates on recent stroke therapy research and to give an opportunity for the participants to discuss how these results may be implemented into clinical routine. Several......://www.eso-karolinska.org/2016 and http://eso-stroke.org) and recommendations which were prepared by a writing committee consisting of session chair(s), secretary and speakers and presented to the 312 participants of the meeting. In the open meeting, general participants commented on the consensus statement and recommendations...

  13. ESO adaptive optics facility progress and first laboratory test results

    Science.gov (United States)

    Arsenault, Robin; Madec, Pierre-Yves; Paufique, Jérome; La Penna, Paolo; Stroebele, Stefan; Vernet, Elise; Pirard, Jean-Francois; Hackenberg, Wolfgang; Kuntschner, Harald; Kolb, Johann; Muller, Nicolas; Garcia-Rissmann, Aurea; Le Louarn, Miska; Amico, Paola; Hubin, Norbert; Lizon, Jean-Louis; Ridings, Rob; Haguenauer, Pierre; Abad, Jose A.; Fischer, Gerhard; Heinz, Volker; Kiekebusch, Mario; Argomedo, Javier; Conzelmann, Ralf; Tordo, Sebastien; Donaldson, Rob; Soenke, Christian; Duhoux, Philippe; Fedrigo, Enrico; Delabre, Bernard; Jost, Andrea; Duchateau, Michel; Downing, Mark; Reyes Moreno, Javier; Manescau, Antonio; Bonaccini Calia, Domenico; Quattri, Marco; Dupuy, Christophe; Guidolin, Ivan M.; Comin, Mauro; Guzman, Ronald; Buzzoni, Bernard; Quentin, Jutta; Lewis, Steffan; Jolley, Paul; Kraus, Max; Pfrommer, Thomas; Biasi, Roberto; Gallieni, Daniele; Stuik, Remko; Kaenders, Wilhelm; Ernstberger, Bernhard; Friedenauer, Axel

    2014-07-01

    The Adaptive Optics Facility project is completing the integration of its systems at ESO Headquarters in Garching. The main test bench ASSIST and the 2nd Generation M2-Unit (hosting the Deformable Secondary Mirror) have been granted acceptance late 2012. The DSM has undergone a series of tests on ASSIST in 2013 which have validated its optical performance and launched the System Test Phase of the AOF. This has been followed by the performance evaluation of the GRAAL natural guide star mode on-axis and will continue in 2014 with its Ground Layer AO mode. The GALACSI module (for MUSE) Wide-Field-Mode (GLAO) and the more challenging Narrow-Field-Mode (LTAO) will then be tested. The AOF has also taken delivery of the second scientific thin shell mirror and the first 22 Watt Sodium laser Unit. We will report on the system tests status, the performances evaluated on the ASSIST bench and advancement of the 4Laser Guide Star Facility. We will also present the near future plans for commissioning on the telescope and some considerations on tools to ensure an efficient operation of the Facility in Paranal.

  14. A 3000 TNOs Survey Project at ESO La Silla

    Science.gov (United States)

    Boehnhardt, H.; Hainaut, O.

    We propose a wide-shallow TNO search to be done with the Wide Field Imager (WFI) instrument at the 2.2m MPG/ESO telescope in La Silla/Chile. The WFI is a half-deg camera equipped with an 8kx8k CCD (0.24 arcsec/pixel). The telescope can support excellent seeing quality down to 0.5arcsec FWHM. A TNO search pilot project was run with the 2.2m+WFI in 1999: images with just 1.6sdeg sky coverage and typically 24mag limiting brightness revealed 6 new TNOs when processed with our new automatic detection program MOVIE. The project is now continued on a somewhat larger scale in order to find more TNOs and to fine-tune the operational environment for a full automatic on-line detection, astrometry and photometry of the objects at the telescope. The future goal is to perform - with the 2.2m+WFI and in an international colaboration - an even larger TNO survey over a major part of the sky (typically 2000sdeg in and out of Ecliptic) down to 24mag. Follow-up astrometry and photometry of the expected more than 3000 discovered objects will secure their orbital and physical characterisation for synoptic dynamical and taxonomic studies of the Transneptunian population.

  15. Gender Systematics in Telescope Time Allocation at ESO

    Science.gov (United States)

    Patat, F.

    2016-09-01

    The results of a comprehensive statistical analysis of gender systematics in the time allocation process at ESO are presented. The sample on which the study is based includes more than 13 000 Normal and Short proposals, submitted by about 3000 principal investigators (PI) over eight years. The genders of PIs, and of the panel members of the Observing Programmes Committee (OPC), were used, together with their career level, to analyse the grade distributions and the proposal success rates. Proposals submitted by female PIs show a significantly lower probability of being allocated time. The proposal success rates (defined as number of top ranked runs over requested runs) are 16.0 ± 0.6% and 22.0 ± 0.4% for females and males, respectively. To a significant extent the disparity is related to different input distributions in terms of career level. The seniority of male PIs is significantly higher than that of female PIs, with only 34% of the female PIs being professionally employed astronomers (compared to 53% for male PIs). A small, but statistically significant, gender-dependent behaviour is measured for the OPC referees: both genders show the same systematics, but they are larger for males than females. The PI female/male fraction is very close to 30/70; although far from parity, the fraction is higher than that observed, for instance, among IAU membership.

  16. Scisoft -- A Collection of Astronomical Software for ESO Users

    Science.gov (United States)

    Hook, Richard N.; Maguire, Kevin; Pirzkal, Norbert; Filippi, Giorgio

    The European Southern Observatory operates four geographically separated sites, the headquarters in Germany and an office and two observatories at separate remote locations in Chile. Staff astronomers, fellows, students and visitors are active at all four sites and need appropriate software tools. In the past these requirements were addressed by local computer management staff in response to requests. This resulted in different tools being available at different sites, often in different versions and with different levels of support. These differences often resulted in inconvenience, particularly for visitors. In an attempt to address these problems a project called ``Scisoft" was established within ESO. Scisoft has put together a standardized collection of software in three versions covering the supported computer platforms within the organization - Solaris, HP-UX and Linux. The contents of the collection are determined by the demands of users at all sites and standardized for each release which occurs at intervals of about 6 months. External releases of a slightly restricted collection are now also available.

  17. Upgrade of ESO's FIERA CCD Controller and PULPO Subsystem

    Science.gov (United States)

    Reyes-Moreno, J.; Geimer, C.; Balestra, A.; Haddad, N.

    An overview of FIERA is presented with emphasis on its recent upgrade to PCI. The PCI board hosts two DSPs, one for real time control of the camera and another for on-the-fly processing of the incoming video data. In addition, the board is able to make DMA transfers, to synchronize to other boards alike, to be synchronized by a TIM bus and to control PULPO via RS232. The design is based on the IOP480 chip from PLX, for which we have developed a device driver for both Solaris and Linux. One computer is able to host more than one board and therefore can control an array of FIERA detector electronics. PULPO is a multifunctional subsystem widely used at ESO for the housekeeping of CCD cryostat heads and for shutter control. The upgrade of PULPO is based on an embedded PC running Linux. The upgraded PULPO is able to handle 29 temperature sensors, control 8 heaters and one shutter, read out one vacuum sensor and log any combination of parameters.

  18. Gender Systematics in Telescope Time Allocation at ESO

    CERN Document Server

    Patat, Ferdinando

    2016-01-01

    The results of a comprehensive statistical analysis of gender systematics in the time allocation process at European Southern Observatory (ESO) are presented. The sample on which the study is based includes more than 13000 Normal and Short proposals, submitted by about 3000 principal investigators (PI) over eight years. The genders of PIs, and of the panel members of the Observing Programmes Committee (OPC), were used, together with their career level, to analyse the grade distributions and the proposal success rates. Proposals submitted by female PIs show a significantly lower probability of being allocated time. The proposal success rates (defined as number of top ranked runs over requested runs) are 16.0$\\pm$0.6% and 22.0$\\pm$0.4% for females and males, respectively. To a significant extent the disparity is related to different input distributions in terms of career level. The seniority of male PIs is significantly higher than that of female PIs, with only 34% of the female PIs being professionally employe...

  19. The Spanish in-kind contribution to ESO - Pipelines

    Science.gov (United States)

    de Bilbao, L.; Ballester, P.

    2011-11-01

    Ever since entering ESO in 2006, Spain has made an in-kind contribution invarious fields. In the Pipeline Systems Department (PSD), this contribution hasbeen made to a number of projects, in particular to the CPL (Common Pipeline Library), to the pipelines of the instruments ISAAC, SofI and FORS, and to theintegration of the pipeline for the new VISTA telescope into the DFS (Data FlowSystem) at Paranal. Some of these projects started with the VLT a decade ago, and have experiencedan evolution since, as a consequence of standardization processes, of thesearch of elements in common and, especially in the last couple of years, ofthe efforts to provide the astronomy community with 'science-ready' dataproducts. At the same time, the PSD faces new challenges today, as the dramatic increase in the data volume of the Paranal Observatory since the start of operations of VISTA, or the needs of the pipelines of the future instruments of the E-ELT. In the latter, more concretely, the current status of the CPL is being analyzed, with the goal of establishing the necessary changes to meet those future needs.In this article we introduce briefly these projects and detail the Spanish in-kind contribution to them.

  20. Fe I Oscillator Strengths for the Gaia-ESO Survey

    CERN Document Server

    Ruffoni, M P; Lawler, J E; Brewer, N R; Lind, K; Nave, G; Pickering, J C

    2014-01-01

    The Gaia-ESO Public Spectroscopic Survey (GES) is conducting a large-scale study of multi-element chemical abundances of some 100 000 stars in the Milky Way with the ultimate aim of quantifying the formation history and evolution of young, mature and ancient Galactic populations. However, in preparing for the analysis of GES spectra, it has been noted that atomic oscillator strengths of important Fe I lines required to correctly model stellar line intensities are missing from the atomic database. Here, we present new experimental oscillator strengths derived from branching fractions and level lifetimes, for 142 transitions of Fe I between 3526 {\\AA} and 10864 {\\AA}, of which at least 38 are urgently needed by GES. We also assess the impact of these new data on solar spectral synthesis and demonstrate that for 36 lines that appear unblended in the Sun, Fe abundance measurements yield a small line-by-line scatter (0.08 dex) with a mean abundance of 7.44 dex in good agreement with recent publications.

  1. Weak lensing mass reconstructions of the ESO Distant Cluster Survey

    CERN Document Server

    Clowe, D; Aragón-Salamanca, A; Bremer, M; De Lucia, G; Halliday, C; Jablonka, P; Milvang-Jensen, B; Pellò, R; Poggianti, B M; Rudnick, G; Saglia, R; Simard, L; White, S; Zaritsky, D

    2005-01-01

    We present weak lensing mass reconstructions for the 20 high-redshift clusters i n the ESO Distant Cluster Survey. The weak lensing analysis was performed on deep, 3-color optical images taken with VLT/FORS2, using a composite galaxy catalog with separate shape estimators measured in each passband. We find that the EDisCS sample is composed primarily of clusters that are less massive than t hose in current X-ray selected samples at similar redshifts, but that all of the fields are likely to contain massive clusters rather than superpositions of low mass groups. We find that 7 of the 20 fields have additional massive structures which are not associated with the clusters and which can affect the weak lensing mass determination. We compare the mass measurements of the remaining 13 clusters with luminosity measurements from cluster galaxies selected using photometric redshifts and find evidence of a dependence of the cluster mass-to-light ratio with redshift. Finally we determine the noise level in the shear meas...

  2. Science-Grade Imaging Data for HAWK-I, VIMOS, and VIRCAM: The ESO-UK Pipeline Collaboration

    Science.gov (United States)

    Neeser, M.; Lewis, J.; Madsen, G.; Yoldas, A.; Irwin, M.; Gabasch, A.; Coccato, L.; García-Dabó, C. E.; Romaniello, M.; Freudling, W.; Ballester, P.

    2016-12-01

    A new chapter for ESO science-grade data has begun with the implementa-tion of three new pipelines developed for the HAWK-I, VIMOS and VIRCAM instruments. The HAWK-I and VIMOS image archives at ESO have been completely reprocessed using these new pipelines, and these data are now publicly available. This article introduces the work done to bring these pipelines to the level of science-grade, their use in reprocessing ESO archival data, and their dissemination into ESO science operations and to the ESO community.

  3. Advances in the Research of Tumor Antigen NY-ESO-1%肿瘤抗原NY-ESO-1研究进展

    Institute of Scientific and Technical Information of China (English)

    高丹

    2008-01-01

    NY-ESO-1是肿瘤-睾丸(cancer-testis,CT)抗原家族成员之一,在许多不同类型的人类肿瘤中都有表达,是迄今发现的最具免疫原性的肿瘤抗原之一.NY-ESO-1可以在阳性表达肿瘤患者体内诱导自发性体液和T细胞免疫应答,因此在肿瘤疫苗研制中具有非常广泛的前景.

  4. The Gaia-ESO Survey: Probes of the inner disk abundance gradient

    National Research Council Canada - National Science Library

    Jacobson, H. R; Friel, E. D; Jilkova, L; Magrini, L; Bragaglia, A; Vallenari, A; Tosi, M; Randich, S; Donati, P; Cantat-Gaudin, T; Sordo, R; Smiljanic, R; Overbeek, J. C; Carraro, G; Tautvaisiene, G; Roman, I. San; Villanova, S; Geisler, D; Munoz, C; Jimenez-Esteban, F; Tang, B; Gilmore, G; Alfaro, E. J; Bensby, T; Flaccomio, E; Koposov, S. E; Korn, Andreas J; Pancino, E; Recio-Blanco, A; Casey, A. R; Costado, M. T; Franciosini, E; Heiter, Ulrike; Hill, V; Hourihane, A; Lardo, C; de laverny, P; Lewis, J; Monaco, L; Morbidelli, L; Sacco, G. G; Sousa, S. G; Worley, C. C; Zaggia, S

    2016-01-01

    ... characterize the gradient in this part of the disk. Methods. We used the Gaia-ESO Survey (GES) [Fe/H] values and stellar parameters for stars in 12 open clusters in the inner disk from GES-UVES data...

  5. T cells targeting NY-ESO-1 demonstrate efficacy against disseminated neuroblastoma

    OpenAIRE

    Singh, Nathan; Kulikovskaya, Irina; Barrett, David M.; Binder-Scholl, Gwendolyn; Jakobsen, Bent; Martinez, Daniel; Pawel, Bruce; June, Carl H.; Kalos, Michael D.; Grupp, Stephan A.

    2015-01-01

    The cancer-testis antigen NY-ESO-1 is expressed by many solid tumors and has limited expression by mature somatic tissues, making it a highly attractive target for tumor immunotherapy. Targeting NY-ESO-1 using engineered T cells has demonstrated clinical efficacy in the treatment of some adult tumors. Neuroblastoma is a significant cause of cancer mortality in children, and is a tumor type shown to be responsive to immunotherapies. We evaluated a large panel of primarily resected neuroblastom...

  6. PillCam ESO versus esophagogastroduodenoscopy in esophageal variceal screening: A decision analysis.

    Science.gov (United States)

    White, Christopher M; Kilgore, Meredith L

    2009-01-01

    PillCam ESO has been evaluated as a possible strategy to screen patients with cirrhosis for esophageal varices, but current guidelines recommend patients undergo screening with esophagogastroduodenoscopy (EGD), as it is currently the gold standard. Although recent data have suggested that PillCam ESO may be an acceptable alternative for screening, there is limited data on its cost-effectiveness compared with other screening modalities. This study was performed to compare the cost-effectiveness of PillCam ESO versus EGD for esophageal variceal screening. Markov models were constructed to compare 2 screening strategies: PillCam ESO versus EGD. In each arm, patients were followed for a time horizon of 15 years in 1-year transition intervals. All variables, transition probabilities, and costs were derived from the medical literature, and sensitivity analyses were performed on the different variables in the model. Base-case analysis shows that PillCam ESO is associated with an average expected cost of $22,589 and an average expected effectiveness measure of 12.81 life-years. EGD is associated with an average expected cost of $23,083 and an average expected effectiveness measure of 12.67 life-years. PillCam ESO was found to dominate EGD as a screening strategy for patients with cirrhosis. Sensitivity analyses found several variables within the model to have influential effects on the results. PillCam ESO is the dominant strategy for screening patients with cirrhosis for esophageal varices. However, based on a small difference in costs and effectiveness between each strategy, the results would suggest that PillCam ESO and EGD are essentially equivalent strategies.

  7. Diagnostic and therapeutic relevance of NY-ESO-1 expression in oral squamous cell carcinoma.

    Science.gov (United States)

    Ries, Jutta; Mollaoglu, Nur; Vairaktaris, Eleftherios; Neukam, Friedrich W; Nkenke, Emeka

    2009-12-01

    Cancer/testis antigen 1B (NY-ESO-1) is exclusively expressed in various types of tumor but not in healthy normal tissue, except testis, and induces strong cellular and humoral immune responses. Therefore, it represents an ideal target for diagnostic and immunotherapeutic applications. The aim of the study was to investigate the expression of NY-ESO-1 in oral squamous cell carcinoma (OSCC) to determine its impact as a diagnostic parameter or a therapeutic target for oral cancer. A total of 65 OSCC and 20 normal oral mucosal samples of otherwise healthy volunteers were included in this study. Expression of NY-ESO-1 was determined using reverse transcriptase polymerase chain reaction (RT-PCR). The results were correlated to diagnosis and clinicopathological parameters. NY-ESO-1 was expressed in 27.7% of the investigated tumor samples, but not in normal oral mucosal. The correlation between NY-ESO-1 expression and malignancy was significant (p=0.008). The prevalence of NY-ESO-1 expression was significantly associated with tumor size (p=0.033), but not with histological grading, positive lymph node status or clinical stage of disease. NY-ESO-1 expression is restricted to OSCC, clearly indicating malignancy. However, the expression rate of this antigen is too low for clinical application but it might be a useful additional biomarker within a multiple marker system for the diagnosis of OSCC. In addition, NY-ESO-1 might be a candidate for immunotherapy and polyvaccination in patients suffering from OSCC.

  8. NY-ESO-1 (CTAG1B) expression in mesenchymal tumors.

    Science.gov (United States)

    Endo, Makoto; de Graaff, Marieke A; Ingram, Davis R; Lim, Simin; Lev, Dina C; Briaire-de Bruijn, Inge H; Somaiah, Neeta; Bovée, Judith V M G; Lazar, Alexander J; Nielsen, Torsten O

    2015-04-01

    New York esophageal squamous cell carcinoma 1 (NY-ESO-1, CTAG1B) is a cancer-testis antigen and currently a focus of several targeted immunotherapeutic strategies. We performed a large-scale immunohistochemical expression study of NY-ESO-1 using tissue microarrays of mesenchymal tumors from three institutions in an international collaboration. A total of 1132 intermediate and malignant and 175 benign mesenchymal lesions were enrolled in this study. Immunohistochemical staining was performed on tissue microarrays using a monoclonal antibody for NY-ESO-1. Among mesenchymal tumors, myxoid liposarcomas showed the highest positivity for NY-ESO-1 (88%), followed by synovial sarcomas (49%), myxofibrosarcomas (35%), and conventional chondrosarcomas (28%). Positivity of NY-ESO-1 in the remaining mesenchymal tumors was consistently low, and no immunoreactivity was observed in benign mesenchymal lesions. On the basis of these findings, nearly 90% of myxoid liposarcomas, as well as a significant proportion of synovial sarcomas, myxofibrosarcomas, and conventional chondrosarcomas are good candidates for immunotherapy targeting NY-ESO-1.

  9. NY-ESO-1 as a potential immunotherapeutic target in renal cell carcinoma.

    Science.gov (United States)

    Giesen, Eva; Jilaveanu, Lucia B; Parisi, Fabio; Kluger, Yuval; Camp, Robert L; Kluger, Harriet M

    2014-07-30

    Novel immune therapies targeting tumor specific antigens are being developed. Our purpose was to determine expression of the cancer testes antigen NY-ESO-1 in renal cell carcinoma (RCC), as NY-ESO-1 targeting approaches, particularly adoptive cell therapy, have not been evaluated in this disease. We employed tissue microarrays containing >300 unique RCC cases and adjacent benign renal tissue to determine NY-ESO-1 expression using a quantitative immunofluorescence method. In addition, we studied NY-ESO-1 expression in 35 matched primary and metastatic RCC specimens to assess concordance between different tumor sites. NY-ESO-1 was highly expressed in a subset of RCCs. Expression in primary RCC specimens was significantly higher than adjacent normal renal tissue (PESO-1 expression seen in clear cell RCC suggests that NY-ESO-1 targeting approaches should be studied in this disease. Expression is higher in metastatic sites, and discordance between primary and metastatic sites in some patients suggests that patient selection for these therapies should be based on expression in metastatic rather than nephrectomy specimens.

  10. Three novel NY-ESO-1 epitopes bound to DRB1*0803, DQB1*0401 and DRB1*0901 recognized by CD4 T cells from CHP-NY-ESO-1-vaccinated patients.

    Science.gov (United States)

    Mizote, Yu; Taniguchi, Taku; Tanaka, Kei; Isobe, Midori; Wada, Hisashi; Saika, Takashi; Kita, Shoichi; Koide, Yukari; Uenaka, Akiko; Nakayama, Eiichi

    2010-07-19

    Three novel NY-ESO-1 CD4 T cell epitopes were identified using PBMC obtained from patients who were vaccinated with a complex of cholesterol-bearing hydrophobized pullulan (CHP) and NY-ESO-1 protein (CHP-NY-ESO-1). The restriction molecules were determined by antibody blocking and using various EBV-B cells with different HLA alleles as APC to present peptides to CD4 T cells. The minimal epitope peptides were determined using various N- and C-termini truncated peptides deduced from 18-mer overlapping peptides originally identified for recognition. Those epitopes were DRB1*0901-restricted NY-ESO-1 87-100, DQB1*0401-restricted NY-ESO-1 95-107 and DRB1*0803-restricted NY-ESO-1 124-134. CD4 T cells used to determine those epitope peptides recognized EBV-B cells or DC that were treated with recombinant NY-ESO-1 protein or NY-ESO-1-expressing tumor cell lysate, suggesting that the epitope peptides are naturally processed. These CD4 T cells showed a cytokine profile with Th1 characteristics. Furthermore, NY-ESO-1 87-100 peptide/HLA-DRB1*0901 tetramer staining was observed. Multiple Th1-type CD4 T cell responses are beneficial for inducing effective anti-tumor responses after NY-ESO-1 protein vaccination. (c) 2010 Elsevier Ltd. All rights reserved.

  11. [Prokaryotic expression, purification and identification of NY-ESO-1/GST fusion protein in E.coli].

    Science.gov (United States)

    Tang, Lei; Song, Chao-jun; Sun, Yuan-jie; Li, Na; Wei, Yu-ying; Sun, Yi; Yang, Kun

    2012-10-01

    To construct an expression plasmid for NY-ESO-1 gene and identify the expression of recombinant protein NY-ESO-1/GST in E.coli. NY-ESO-1 segment was amplified from the testis cDNA library by RT-PCR and cloned into the prokaryotic expression vector pGEX4T-1 downstream tagged by GST to construct the expression plasmid pGEX-4T1-NY-ESO-1. The recombinant vector was transformed to BL21 (DE3) and NY-ESO-1/GST fusion protein was induced expression by IPTG. The protein was purified by urea elution and identified by SDS-PAGE and Western blotting. The NY-ESO-1 segment was successfully amplified and its sequence was identical with that published in GenBank. The BL21 (DE3) pLysS containing the pGEX-4T1-NY-ESO-1 expressed a M(r); 44 000 fusion protein under the induction of IPTG. The purity of the protein was 90%. Western blotting proved that NY-ESO-1/GST had a specific reaction with anti-GST mAb. The prokaryotic expression vector of NY-ESO-1 has been constructed and the fusion protein NY-ESO-1/GST of high purity is successfully expressed.

  12. Transfection of NY-ESO-1 specific TCR improves the specific cytotoxicity of human PBMC to NY-ESO-1 positive tumor cells%转染NY-ESO-1特异性TCR增强人PBMC对NY-ESO-1阳性肿瘤细胞的特异性细胞毒性

    Institute of Scientific and Technical Information of China (English)

    郭佳; 田洲; 顾娜; 徐珩; 闾军

    2013-01-01

    Objective To study whether NY-ESO-1-specific TCR gene transduced into human PBMC (Peripheral Blood Mononuclear Cell, PBMC) can improve its abilities of specifically recognizing and killing tumor cells. Methods pCDNA3. 1-ESO-TCR plasmid was electroporately transferred into PBMC separated from healthy people in vitro and confirmed by RT-PCR. The phenotype analysis after eletroporation was measured by flow cytometry method. The NY-ESO-1 specific peptide (pl57-165) was added into the culture of electroporated PBMC, the IFN-γ level secreted by electroporated PBMC was detected by ELISPOT assay. The specific cytotoxicity in vitro was detected by real time cell analysis (ACEA biosciences). Results The NY-ESO-1-specific TCR fragments in electroporated PBMC were detected by RT-PCR. The specific expression of NY-ESO-TCR in transferred PBMC was significantly higher than that in PBMC transfered with empty vector (P < 0. 05). The positive dots of IFN-γ secretion in transferred PBMC stimulated by peptide pl57-165 was significantly more than that in PBMC transfered with empty vector (P <0. 05); The specific cytotoxicity of transferred PBMC was obviously enhanced than PBMC transduced with empty vector. Conclusions The specific cytotoxicity of PBMC against NY-ESO-1 positive HepG2 cells is elevated by transduced PBMC with NY-ESO-1 specific TCR, which may stimulate more researches about adoptive immunotherapy of hepatocellular carcinoma.%目的 探讨体外转导NY-ESO-1特异性T细胞受体至人外周血淋巴细胞中,是否可增强转导后细胞体外特异性识别并杀伤肿瘤细胞的能力.方法 将NY-ESO-1特异性TCR质粒(pCDNA3.1-ESO-TCR)体外电转入新分离的正常人PBMC中,RT-PCR法鉴定转导是否成功;采用流式细胞仪分析转导后PBMC表型;用特异性NY-ESO-1b抗原肽(p157-165)刺激转导PBMC后,用ELISPOT法检测PBMC分泌IFN-γ的能力,用实时无标记动态细胞分析仪检测PBMC特异性细胞毒性作用.结果 电转后PBMC

  13. Antibody responses against NY-ESO-1 and HER2 antigens in patients vaccinated with combinations of cholesteryl pullulan (CHP)-NY-ESO-1 and CHP-HER2 with OK-432.

    Science.gov (United States)

    Aoki, Masatoshi; Ueda, Shugo; Nishikawa, Hiroyoshi; Kitano, Shigehisa; Hirayama, Michiko; Ikeda, Hiroaki; Toyoda, Hideki; Tanaka, Kyosuke; Kanai, Michiyuki; Takabayashi, Arimichi; Imai, Hiroshi; Shiraishi, Taizo; Sato, Eiichi; Wada, Hisashi; Nakayama, Eiichi; Takei, Yoshiyuki; Katayama, Naoyuki; Shiku, Hiroshi; Kageyama, Shinichi

    2009-11-16

    Combination vaccines of the NY-ESO-1 protein complexed with cholesteryl pullulan (CHP), CHP-NY-ESO-1, and the truncated 146HER2 protein with CHP, CHP-HER2, were subcutaneously administered with the immuno-adjuvant OK-432 to eight esophageal cancer patients. Vaccination was well-tolerated. NY-ESO-1- and HER2-specific antibody responses were analyzed using the patients' sera and samples from previous single CHP-NY-ESO-1 or CHP-HER2 vaccine trial. The responses to NY-ESO-1 in the combination vaccine study were comparable to the single vaccine. For responses to HER2, there were fewer antibody responses in the combination vaccines. Although there were marked individual variations in the antibody responses to the NY-ESO-1 and HER2 antigens, the reaction patterns to these antigens were comparable within each patient. Antibodies to OK-432 were not augmented. Protein cancer vaccines targeting multiple antigens are feasible.

  14. NY-ESO-1 expression in meningioma suggests a rationale for new immunotherapeutic approaches.

    Science.gov (United States)

    Baia, Gilson S; Caballero, Otavia L; Ho, Janelle S Y; Zhao, Qi; Cohen, Tzeela; Binder, Zev A; Salmasi, Vafi; Gallia, Gary L; Quinones-Hinojosa, Alfredo; Olivi, Alessandro; Brem, Henry; Burger, Peter; Strausberg, Robert L; Simpson, Andrew J G; Eberhart, Charles G; Riggins, Gregory J

    2013-11-01

    Meningiomas are the most common primary intracranial tumors. Surgical resection remains the treatment of choice for these tumors. However, a significant number of tumors are not surgically accessible, recur, or become malignant, necessitating the repetition of surgery and sometimes radiation. Chemotherapy is rarely used and is generally not recognized as an effective treatment. Cancer/testis (CT) genes represent a unique class of genes, which are expressed by germ cells, normally silenced in somatic cells, but activated in various cancers. CT proteins can elicit spontaneous immune responses in patients with cancer and this feature makes them attractive targets for immunotherapy-based approaches. We analyzed mRNA expression of 37 testis-restricted CT genes in a discovery set of 18 meningiomas by reverse transcription PCR. The overall frequency of expression of CT genes ranged from 5.6% to 27.8%. The most frequently expressed was NY-ESO-1, in 5 patients (27.8%). We subsequently analyzed NY-ESO-1 protein expression in a larger set of meningiomas by immunohistochemistry and found expression in 108 of 110 cases. In some cases, NY-ESO-1 expression was diffused and homogenous, but in most instances it was heterogeneous. Importantly, NY-ESO-1 expression was positively correlated with higher grade and patients presenting with higher levels of NY-ESO-1 staining had significantly worse disease-free and overall survival. We have also shown that NY-ESO-1 expression may lead to humoral immune response in patients with meningioma. Considering the limited treatment options for patients with meningioma, the potential of NY-ESO-1-based immunotherapy should be explored. ©2013 AACR.

  15. Efficacy of systemic adoptive transfer immunotherapy targeting NY-ESO-1 for glioblastoma.

    Science.gov (United States)

    Everson, Richard G; Antonios, Joseph P; Lisiero, Dominique N; Soto, Horacio; Scharnweber, Rudi; Garrett, Matthew C; Yong, William H; Li, Ning; Li, Gang; Kruse, Carol A; Liau, Linda M; Prins, Robert M

    2016-03-01

    Immunotherapy is an ideal treatment modality to specifically target the diffusely infiltrative tumor cells of malignant gliomas while sparing the normal brain parenchyma. However, progress in the development of these therapies for glioblastoma has been slow due to the lack of immunogenic antigen targets that are expressed uniformly and selectively by gliomas. We utilized human glioblastoma cell cultures to induce expression of New York-esophageal squamous cell carcinoma (NY-ESO-1) following in vitro treatment with the demethylating agent decitabine. We then investigated the phenotype of lymphocytes specific for NY-ESO-1 using flow cytometry analysis and cytotoxicity against cells treated with decitabine using the xCelligence real-time cytotoxicity assay. Finally, we examined the in vivo application of this immune therapy using an intracranially implanted xenograft model for in situ T cell trafficking, survival, and tissue studies. Our studies showed that treatment of intracranial glioma-bearing mice with decitabine reliably and consistently induced the expression of an immunogenic tumor-rejection antigen, NY-ESO-1, specifically in glioma cells and not in normal brain tissue. The upregulation of NY-ESO-1 by intracranial gliomas was associated with the migration of adoptively transferred NY-ESO-1-specific lymphocytes along white matter tracts to these tumors in the brain. Similarly, NY-ESO-1-specific adoptive T cell therapy demonstrated antitumor activity after decitabine treatment and conferred a highly significant survival benefit to mice bearing established intracranial human glioma xenografts. Transfer of NY-ESO-1-specific T cells systemically was superior to intracranial administration and resulted in significantly extended and long-term survival of animals. These results reveal an innovative, clinically feasible strategy for the treatment of glioblastoma. © The Author(s) 2015. Published by Oxford University Press on behalf of the Society for Neuro

  16. Heteroclitic serological response in esophageal and prostate cancer patients after NY-ESO-1 protein vaccination.

    Science.gov (United States)

    Kawada, Junji; Wada, Hisashi; Isobe, Midori; Gnjatic, Sacha; Nishikawa, Hiroyoshi; Jungbluth, Achim A; Okazaki, Nami; Uenaka, Akiko; Nakamura, Yurika; Fujiwara, Shinichi; Mizuno, Naoaki; Saika, Takashi; Ritter, Erika; Yamasaki, Makoto; Miyata, Hiroshi; Ritter, Gerd; Murphy, Roger; Venhaus, Ralph; Pan, Linda; Old, Lloyd J; Doki, Yuichiro; Nakayama, Eiichi

    2012-02-01

    NY-ESO-1 is a prototypic cancer/testis antigen. In a recent phase I clinical trial, we vaccinated 13 patients bearing NY-ESO-1-expressing tumors with a complex of cholesterol-bearing hydrophobized pullulan (CHP) and NY-ESO-1 protein (CHP-NY-ESO-1) and showed efficient induction of NY-ESO-1 antibody, and CD4 and CD8 T cell responses using peripheral blood from the patients. In our study, we analyzed heteroclitic serological responses in those patients after vaccination. Serological response against 11 tumor antigens including MAGE-A1, MAGE-A3, MAGE-A4, CT7/MAGEC1, CT10/MAGEC2, CT45, CT46/HORMAD1, SOX2, SSX2, XAGE1B and p53 was examined by enzyme-linked immunosorbent assay (ELISA) using sera from ten vaccinated patients. Expression of tumor antigens was determined by reverse transcription-polymerase chain reaction or immunohistochemistry. Eight of nine patients who showed antibody responses against NY-ESO-1 also showed an antibody response against at least 1 of these 11 tumor antigens after vaccination. In one patient, seven tumor antigens were recognized. Specificity analysis of the antibody response by ELISA using control recombinant proteins and synthetic peptides and by Western blot showed that the response was not against His6-tag and/or bacterial products included in a preparation of CHP-NY-ESO-1 used for vaccination. Thus, heteroclitic serological responses appear to be indicative of the overall immune response against the tumor, and their analysis could be useful for immune monitoring in cancer vaccine. Copyright © 2011 UICC.

  17. Clumpy dust clouds and extended atmosphere of the AGB star W Hya revealed with VLT/SPHERE-ZIMPOL and VLTI/AMBER II. Time variations between pre-maximum and minimum light

    CERN Document Server

    Ohnaka, Keiichi; Hofmann, Karl-Heinz

    2016-01-01

    Our recent visible polarimetric images of the well-studied AGB star W Hya taken at pre-maximum light (phase 0.92) with VLT/SPHERE-ZIMPOL have revealed clumpy dust clouds close to the star at ~2 Rstar. We present second-epoch SPHERE-ZIMPOL observations of W Hya at minimum light (phase 0.54) in the continuum (645, 748, and 820 nm), in the Halpha line (656.3 nm), and in the TiO band (717 nm) as well as high-spectral resolution long-baseline interferometric observations in 2.3 micron CO lines with the AMBER instrument at the Very Large Telescope Interferometer (VLTI). The high-spatial resolution polarimetric images have allowed us to detect clear time variations in the clumpy dust clouds as close as 34--50~mas (1.4--2.0 Rstar) to the star. We detected the formation of a new dust cloud and the disappearance of one of the dust clouds detected at the first epoch. The Halpha and TiO emission extends to ~150 mas (~6 Rstar), and the Halpha images reveal time variations. The degree of linear polarization is higher at mi...

  18. Schools Need the PR's.

    Science.gov (United States)

    Palmer, George C.

    1980-01-01

    PR is an acronym standing for philosophic revitalization, planned reactions, proper rhetoric, and personal responsibility. A look at these PRs can challenge school personnel's thinking toward meeting the goals of the district. (Author/MLF)

  19. ESO-Based Fuzzy Sliding-Mode Control for a 3-DOF Serial-Parallel Hybrid Humanoid Arm

    Directory of Open Access Journals (Sweden)

    Yueling Wang

    2014-01-01

    Full Text Available This paper presents a unique ESO-based fuzzy sliding-mode controller (FSMC-ESO for a 3-DOF serial-parallel hybrid humanoid arm (HHA for the trajectory tracking control problem. The dynamic model of the HHA is obtained by Lagrange method and is nonlinear in dynamics with inertia uncertainty and external disturbance. The FSMC-ESO is based on the combination of the sliding-mode control (SMC, extended state observer (ESO theory, and fuzzy control (FC. The SMC is insensitive to both internal parameter uncertainties and external disturbances. The motivation for using ESO is to estimate the disturbance in real-time. The fuzzy parameter self-tuning strategy is proposed to adjust the switching gain on line according to the running state of the system. The stability of the system is guaranteed in the sense of the Lyapunov stability theorem. The effectiveness and robustness of the designed FSMC-ESO are illustrated by simulations.

  20. ESO Telescope Designer Raymond Wilson Wins Prestigious Kavli Award for Astrophysics

    Science.gov (United States)

    2010-06-01

    Raymond Wilson, whose pioneering optics research at ESO made today's giant telescopes possible thanks to "active optics" technology, has been awarded the 2010 Kavli Prize in astrophysics. The founder and original leader of the Optics and Telescopes Group at ESO, Wilson shares the million-dollar prize with two American scientists, Jerry Nelson and Roger Angel. The biennial prize, presented by the Norwegian Academy of Science and Letters, the Kavli Foundation, and the Norwegian Ministry of Education and Research, was instituted in 2008 and is given to researchers who significantly advance knowledge in the fields of nanoscience, neuroscience, and astrophysics, acting as a complement to the Nobel Prize. The award is named for and funded by Fred Kavli, the Norwegian entrepreneur and phi­lanthropist who later founded the Kavlico Corpora­tion in the US - today one of the world's largest suppliers of sensors for aeronautic, automotive and industrial applications. Wilson, who joined ESO in 1972, strived to achieve optical perfection, developing the concept of active optics as a way to enhance the size of telescopic primary mirrors. It is the size of these mirrors that determines the ability of a telescope to gather light and study faint and distant objects. Before active optics, mirrors over six metres in diameter were impossible, being too heavy, costly, and likely to bend from gravity and temperature changes. The use of active optics, which preserves optimal image quality by continually adjusting the mirror's shape during observations, made lighter, thinner so-called "meniscus mirrors" possible. Wilson first led the implementation of active optics in the revolutionary New Technology Telescope at ESO's La Silla Observatory, and continued to develop and improve the technology until his retirement in 1993. Since then, active optics have become a standard part of modern astronomy, applied in every big telescope including ESO's Very Large Telescope (VLT), a telescope array

  1. CTLA-4 blockade enhances polyfunctional NY-ESO-1 specific T cell responses in metastatic melanoma patients with clinical benefit.

    Science.gov (United States)

    Yuan, Jianda; Gnjatic, Sacha; Li, Hao; Powel, Sarah; Gallardo, Humilidad F; Ritter, Erika; Ku, Geoffrey Y; Jungbluth, Achim A; Segal, Neil H; Rasalan, Teresa S; Manukian, Gregor; Xu, Yinyan; Roman, Ruth-Ann; Terzulli, Stephanie L; Heywood, Melanie; Pogoriler, Evelina; Ritter, Gerd; Old, Lloyd J; Allison, James P; Wolchok, Jedd D

    2008-12-23

    Blockade of inhibitory signals mediated by cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) has been shown to enhance T cell responses and induce durable clinical responses in patients with metastatic melanoma. The functional impact of anti-CTLA-4 therapy on human immune responses is still unclear. To explore this, we analyzed immune-related adverse events and immune responses in metastatic melanoma patients treated with ipilimumab, a fully human anti-CTLA-4 monoclonal antibody. Fifteen patients were selected on the basis of availability of suitable specimens for immunologic monitoring, and eight of these showed evidence of clinical benefit. Five of the eight patients with evidence of clinical benefit had NY-ESO-1 antibody, whereas none of seven clinical non-responders was seropositive for NY-ESO-1. All five NY-ESO-1 seropositive patients had clearly detectable CD4(+) and CD8(+) T cells against NY-ESO-1 following treatment with ipilimumab. One NY-ESO-1 seronegative clinical responder also had a NY-ESO-1 CD4(+) and CD8(+) T cell response, possibly related to prior vaccination with NY-ESO-1. Among five clinical non-responders analyzed, only one had a NY-ESO-1 CD4(+) T cell response and this patient did not have detectable anti-NY-ESO-1 antibody. Overall, NY-ESO-1-specific T cell responses increased in frequency and functionality during anti-CTLA-4 treatment, revealing a polyfunctional response pattern of IFN-gamma, MIP-1beta and TNF-alpha. We therefore suggest that CTLA-4 blockade enhanced NY-ESO-1 antigen-specific B cell and T cell immune responses in patients with durable objective clinical responses and stable disease. These data provide an immunologic rationale for the efficacy of anti-CTLA-4 therapy and call for immunotherapeutic designs that combine NY-ESO-1 vaccination with CTLA-4 blockade.

  2. Radio-continuum jets around the peculiar galaxy pair ESO 295-IG022

    Directory of Open Access Journals (Sweden)

    Filipović M.D.

    2010-01-01

    Full Text Available We report new radio-continuum observations with the Australia Telescope Compact Array (ATCA of the region surrounding the peculiar galaxy pair ESO 295-IG022 at the centre of the poor cluster Abell S0102. We observed this cluster at wavelengths of λ=20/13 and 6/3 cm with the ATCA 6 km array. With these configurations, we achieved a resolution of ~2'' at 3 cm which is sufficient to resolve the jet-like structure of ~3' length detected at 20 cm. From our new high resolution images at 6 and 3 cm we confirm the presence of a double jet structure, most likely originating from the northern galaxy (ESO 295-IG022-N, bent and twisted towards the south. We found the spectral index of the jet to be very steep (α=-1.32. No point source was detected that could be associated with the core of ESO 295-IG022-N. On the other hand, ESO 295-IG022-S does not show any jet structure, but does show a point radio source. This source has variable flux and spectral index, and appears to be superposed on the line-of-sight of the jets (seen at 20-cm originating from the northern galaxy ESO 295-IG022-N. Finally, regions of very high and somewhat well ordered polarization were detected at the level of 70%.

  3. Radio-Continuum Jets Around the Peculiar Galaxy Pair ESO 295-IG022

    Science.gov (United States)

    Filipovic, M. D.; Crawford, E. J.; Jones, P. A.; White, G. L.

    2010-12-01

    We report new radio-continuum observations with the Australia Telescope Compact Array (ATCA) of the region surrounding the peculiar galaxy pair ESO 295-IG022 at the centre of the poor cluster Abell S0102. We observed this cluster at wavelengths of λ=20/13 and 6/3 cm with the ATCA 6 km array. With these configurations, we achieved a resolution of ˜2arcsec at 3 cm which is sufficient to resolve the jet-like structure of ˜3 arcmin length detected at 20 cm. From our new high resolution images at 6 and 3 cm we confirm the presence of a double jet structure, most likely originating from the northern galaxy (ESO 295-IG022-N), bent and twisted towards the south. We found the spectral index of the jet to be very steep (α=-1.32). No point source was detected that could be associated with the core of ESO 295-IG022-N. On the other hand, ESO 295-IG022-S does not show any jet structure, but does show a point radio source. This source has variable flux and spectral index, and appears to be superposed on the line-of-sight of the jets (seen at 20-cm) originating from the northern galaxy ESO 295-IG022-N. Finally, regions of very high and somewhat well ordered polarisation were detected at the level of 70 per cent.

  4. Galactic arch{\\ae}ology of the ESO 533-4 thick disc

    CERN Document Server

    Comerón, S; Janz, J; Laurikainen, E; Yoachim, P

    2015-01-01

    The formation mechanisms of thick discs are under discussion. Thick discs might have formed either at high redshift on a short time-scale or might have been built slowly over time. They may have an internal or an external origin. Here we study in detail the kinematics and the stellar populations of the thick disc of ESO533-4. ESO533-4 is a nearby bulgeless galaxy. We present the first ever IFU study of an edge-on galaxy with enough depth to study the thick disc. We exposed ESO533-4 with VIMOS@VLT for 6.5hours. The FOV covered an axial extent 0.1-0.7r_25 (1-7kpc). We used pPXF and the MILES library to obtain velocity and stellar population maps. We compared our kinematic data with simple GADGET-2 models. The apparent rotational lag of the thick disc of ESO533-4 is compatible with that expected from the combinations of two effects: differential asymmetric drift and the projection effects arising from studying a disc a few degrees (2-3) away from edge-on. Thus, ESO533-4 contains little or no retrograde material....

  5. Europe to the stars ESO's first 50 years of exploring the southern sky

    CERN Document Server

    Schilling, Govert

    2012-01-01

    The creation of the European Southern Observatory (ESO) in 1962 was the culmination of the dream of leading astronomers from five European countries. Over the years, as more member states joined, ESO constructed the La Silla and Paranal observatories, as well as the Atacama Large Millimeter/submillimeter Array (ALMA) together with partners. ESO is now starting to build the world′s biggest eye on the sky, the European Extremely Large Telescope. At the dawn of 2012, its 50th anniversary year, ESO is ready to enter a new era. One that not even its founding members could have anticipated in their boldest dreams. Constantly at the technological forefront, ESO is ready to tackle new and as yet unimaginable territories of high–precision technology and scientific discovery. Produced especially for ESO′s 50th anniversary, this sumptuously illustrated book takes the reader behind the scenes of the most productive ground–based observatory in the world. It contains the best 300 of ESO′s images, hand–picked fr...

  6. Blasting away a dwarf galaxy: The "tail" of ESO 324-G024

    CERN Document Server

    Johnson, Megan C; Koribalski, Baerbel S; Wang, Jing; Oh, Se-Heon; Hil, Alex; O'Sullivan, Shane; Haan, Sebastian; Serra, Paolo

    2015-01-01

    We present Australia Telescope Compact Array radio data of the dwarf irregular galaxy ESO 324-G024 which is seen in projection against the giant, northern lobe of the radio galaxy Centaurus A (Cen A, NGC 5128). The distorted morphology and kinematics of ESO 324-G024, as observed in the 21 cm spectral line emission of neutral hydrogen, indicate disruptions by external forces. We investigate whether tidal interactions and/or ram pressure stripping are responsible for the formation of the HI tail stretching to the northeast of ESO 324-G024 with the latter being most probable. Furthermore, we closely analyze the sub-structure of Cen A's polarized radio lobes to ascertain whether ESO 324-G024 is located in front, within or behind the northern lobe. Our multi-wavelength, multi-component approach allows us to determine that ESO 324-G024 is most likely behind the northern radio lobe of Cen A. This result helps to constrain the orientation of the lobe, which is likely inclined to our line of sight by approximately 60 ...

  7. Estimation of an NY-ESO-1 expressing HCC cell line by NY-ESO-1b specific CD8+T cells in vitro induced by HLA-A2 restricted NY-ESO-1b peptide%HLA-A2限制性NY-ESO-1b肽段诱导的CD8+ T细胞对稳定表达NY-ESO-1的HepG2肝癌细胞系的杀伤效应

    Institute of Scientific and Technical Information of China (English)

    乔欢; 钱晓萍; 张华刚; 田婵; 陈慰峰

    2005-01-01

    目的:分析体外诱导的NY-ESO-1特异性杀伤性T淋巴细胞对稳定表达NY-ESO-1蛋白的肝细胞性肝癌(hepatocellular carcinoma,HCC)细胞系的杀伤效应,为进一步分析NY-ESO-1蛋白作为疫苗用于治疗HCC的可能性提供实验支持.方法:从HLA-A2阳性的肝癌患者体内分离出外周血单个核细胞,用NY-ESO-1肽段体外诱导特异性杀伤性T淋巴细胞,并通过酶联免疫斑点法分析特异性杀伤性T淋巴细胞对稳定表达NY-ESO-1蛋白的HCC细胞系HepG2细胞的杀伤效应.结果:转染了NY-ESO-1的HepG2细胞(HLA-A2+)可有效地被NY-ESO-1157-165抗原肽诱导的特异性CD8+ T淋巴细胞所识别.效应细胞中大量GrB的释放表明其对稳定转染了NY-ESO-1基因的HepG2细胞有很强的杀伤作用.结论:HepG2细胞中表达的NY-ESO-1蛋白可被此肝癌细胞有效地加工处理,而且HLA-A2限制性的抗原肽NY-ESO-1157-165也可被有效地提呈到细胞表面,从而被效应T细胞所识别.

  8. NY-ESO-1 expression in hepatocellular carcinoma: A potential new marker for early recurrence after surgery

    OpenAIRE

    Xu, Heng; GU, NA; LIU, ZHAO-BO; Zheng, Min; Xiong, Fang; WANG, SI-YING; Li, Ning; Lu, Jun

    2011-01-01

    NY-ESO-1 belongs to the cancer testis antigens (CTA) family, and is identified in a variety of tumors. Certain studies have demonstrated that NY-ESO-1 predicts tumor recurrence and treatment response. No reports are currently available regarding the correlation between NY-ESO-1 and the recurrence of hepatocellular carcinoma (HCC) following surgery. The purpose of the present study was to evaluate the association between NY-ESO-1 and relapse of HCC and to explore the possible mechanisms for th...

  9. NY-ESO-1 expression in hepatocellular carcinoma: A potential new marker for early recurrence after surgery

    OpenAIRE

    2011-01-01

    NY-ESO-1 belongs to the cancer testis antigens (CTA) family, and is identified in a variety of tumors. Certain studies have demonstrated that NY-ESO-1 predicts tumor recurrence and treatment response. No reports are currently available regarding the correlation between NY-ESO-1 and the recurrence of hepatocellular carcinoma (HCC) following surgery. The purpose of the present study was to evaluate the association between NY-ESO-1 and relapse of HCC and to explore the possible mechanisms for th...

  10. La evaluación en etapas escolares similares a la E.S.O. en algunos países de laUnión Europea

    Directory of Open Access Journals (Sweden)

    Ángel J. Rodríguez

    2012-09-01

    Full Text Available En este trabajo se estudian los procedimientos de calificación, organización de los equipos docentes, promoción, titulación, papel de la inspección educativa, recuperación de materias pendientes, uso de la evaluación inicial, de la evaluación y atención a la diversidad, etc. en las etapas educativas equivalentes a la Educación Secundaria Obligatoria (ESO española, en Alemania, Inglaterra y Francia; a través del análisis de la práctica realizada en tres Colegios bilingües ubicados en la isla de Gran Canaria, mediante una entrevista semiestructurada realizada a sus directores y jefes de estudio, que siguen la normativa de sus respectivos países, así como del análisis de su legislación relativa a la evaluación. De esta comparación surgen algunas propuestas para optimizar la práctica educativa canaria y española en esta etapa educativa.In this paper we study the qualification procedures, organization of teaching staff, promotion, certification, inspection role, pending recovery of materials, use of initial assessment, evaluation and attention to diversity, etc. in the stages of education equivalent to Spanish secondary education (ESO, Germany, England and France; through the analysis of the experience gained from three bilingual schools located in Gran Canaria which follow the rules of its own countries. From this comparison, some new proposals arise to optimize the education in the Canary Islands and Spain during this academic level.

  11. A phase I study of vaccination with NY-ESO-1f peptide mixed with Picibanil OK-432 and Montanide ISA-51 in patients with cancers expressing the NY-ESO-1 antigen.

    Science.gov (United States)

    Kakimi, Kazuhiro; Isobe, Midori; Uenaka, Akiko; Wada, Hisashi; Sato, Eiichi; Doki, Yuichiro; Nakajima, Jun; Seto, Yasuyuki; Yamatsuji, Tomoki; Naomoto, Yoshio; Shiraishi, Kenshiro; Takigawa, Nagio; Kiura, Katsuyuki; Tsuji, Kazuhide; Iwatsuki, Keiji; Oka, Mikio; Pan, Linda; Hoffman, Eric W; Old, Lloyd J; Nakayama, Eiichi

    2011-12-15

    We conducted a phase I clinical trial of a cancer vaccine using a 20-mer NY-ESO-1f peptide (NY-ESO-1 91-110) that includes multiple epitopes recognized by antibodies, and CD4 and CD8 T cells. Ten patients were immunized with 600 μg of NY-ESO-1f peptide mixed with 0.2 KE Picibanil OK-432 and 1.25 ml Montanide ISA-51. Primary end points of the study were safety and immune response. Subcutaneous injection of the NY-ESO-1f peptide vaccine was well tolerated. Vaccine-related adverse events observed were fever (Grade 1), injection-site reaction (Grade 1 or 2) and induration (Grade 2). Vaccination with the NY-ESO-1f peptide resulted in an increase or induction of NY-ESO-1 antibody responses in nine of ten patients. The sera reacted with recombinant NY-ESO-1 whole protein as well as the NY-ESO-1f peptide. An increase in CD4 and CD8 T cell responses was observed in nine of ten patients. Vaccine-induced CD4 and CD8 T cells responded to NY-ESO-1 91-108 in all patients with various HLA types with a less frequent response to neighboring peptides. The findings indicate that the 20-mer NY-ESO-1f peptide includes multiple epitopes recognized by CD4 and CD8 T cells with distinct specificity. Of ten patients, two with lung cancer and one with esophageal cancer showed stable disease. Our study shows that the NY-ESO-1f peptide vaccine was well tolerated and elicited humoral, CD4 and CD8 T cell responses in immunized patients. Copyright © 2011 UICC.

  12. The Gaia-ESO Survey: Kinematics of seven Galactic globular clusters

    CERN Document Server

    Lardo, C; Bellazzini, M; Bragaglia, A; Donati, P; Gilmore, G; Randich, S; Feltzing, S; Jeffries, R D; Vallenari, A; Alfaro, E J; Prieto, C Allende; Flaccomio, E; Koposov, S E; Recio-Blanco, A; Bergemann, M; Carraro, G; Costado, M T; Damiani, F; Hourihane, A; Jofre, P; de Laverny, P; Marconi, G; Masseron, T; Morbidelli, L; Sacco, G G; Worley, C C

    2014-01-01

    The Gaia-ESO survey is a large public spectroscopic survey aimed at investigating the origin and formation history of our Galaxy by collecting spectroscopy of representative samples (about 10^5 Milky Way stars) of all Galactic stellar populations, in the field and in clusters. The survey uses globular clusters as intra- and inter-survey calibrators, deriving stellar atmospheric parameters and abundances of a significant number of stars in clusters, along with radial velocity determinations. We used precise radial velocities of a large number of stars in seven globular clusters (NGC 1851, NGC 2808, NGC 4372, NGC 4833, NGC 5927, NGC 6752, and NGC 7078) to validate pipeline results and to preliminarily investigate the cluster internal kinematics. Radial velocity measurements were extracted from FLAMES/GIRAFFE spectra processed by the survey pipeline as part of the second internal data release of data products to ESO. We complemented our sample with ESO archival data obtained with different instrument configurati...

  13. The AMBRE Project: Parameterisation of FGK-type stars from the ESO:HARPS archived spectra

    CERN Document Server

    De Pascale, Marco; de Laverny, Patrick; Recio-Blanco, Alejandra; Hill, Vanessa; Bijaoui, Albert

    2014-01-01

    The AMBRE project is a collaboration between the European Southern Observatory (ESO) and the Observatoire de la Cote d'Azur (OCA). It has been established to determine the stellar atmospheric parameters (effective temperature, surface gravity, global metallicities and abundance of alpha-elements over iron) of the archived spectra of four ESO spectrographs. The analysis of the ESO:HARPS archived spectra is presented. The sample being analysed (AMBRE:HARPS) covers the period from 2003 to 2010 and is comprised of 126688 scientific spectra corresponding to 17218 different stars. For the analysis of the spectral sample, the automated pipeline developed for the analysis of the AMBRE:FEROS archived spectra has been adapted to the characteristics of the HARPS spectra. Within the pipeline, the stellar parameters are determined by the MATISSE algorithm, developed at OCA for the analysis of large samples of stellar spectra in the framework of galactic archaeology. In the present application, MATISSE uses the AMBRE grid ...

  14. A Fruitful Collaboration between ESO and the Max Planck Computing and Data Facility

    Science.gov (United States)

    Fourniol, N.; Zampieri, S.; Panea, M.

    2016-06-01

    The ESO Science Archive Facility (SAF), contains all La Silla Paranal Observatory raw data, as well as, more recently introduced, processed data created at ESO with state-of-the-art pipelines or returned by the astronomical community. The SAF has been established for over 20 years and its current holding exceeds 700 terabytes. An overview of the content of the SAF and the preservation of its content is provided. The latest development to ensure the preservation of the SAF data, provision of an independent backup copy of the whole SAF at the Max Planck Computing and Data Facility in Garching, is described.

  15. Next Generation Bibliometrics and the Evolution of the ESO Telescope Bibliography

    Science.gov (United States)

    Erdmann, C.; Grothkopf, U.

    2010-10-01

    Bibliometric studies typically focus on citation and publication analysis. Due to recent advances in web technology along with greater access to web content, bibliometric research can include statistics and measures that were once difficult to obtain. The European Southern Observatory's Telescope Bibliography (ESO telbib), a content management system for refereed articles containing ESO data, provides an excellent test-bed for exploring next generation bibliometrics. Through web services provided by the NASA Astrophysics Data System (ADS) Abstract Service among others, previously unavailable information can be imported into telbib where it can be analyzed in further detail. Though some telbib features are still in their infancy, some interesting trends can already be derived.

  16. Heritability of strabismus: genetic influence is specific to eso-deviation and independent of refractive error.

    Science.gov (United States)

    Sanfilippo, Paul G; Hammond, Christopher J; Staffieri, Sandra E; Kearns, Lisa S; Melissa Liew, S H; Barbour, Julie M; Hewitt, Alex W; Ge, Dongliang; Snieder, Harold; Mackinnon, Jane R; Brown, Shayne A; Lorenz, Birgit; Spector, Tim D; Martin, Nicholas G; Wilmer, Jeremy B; Mackey, David A

    2012-10-01

    Strabismus represents a complex oculomotor disorder characterized by the deviation of one or both eyes and poor vision. A more sophisticated understanding of the genetic liability of strabismus is required to guide searches for associated molecular variants. In this classical twin study of 1,462 twin pairs, we examined the relative influence of genes and environment in comitant strabismus, and the degree to which these influences can be explained by factors in common with refractive error. Participants were examined for the presence of latent ('phoria') and manifest ('tropia') strabismus using cover-uncover and alternate cover tests. Two phenotypes were distinguished: eso-deviation (esophoria and esotropia) and exo-deviation (exophoria and exotropia). Structural equation modeling was subsequently employed to partition the observed phenotypic variation in the twin data into specific variance components. The prevalence of eso-deviation and exo-deviation was 8.6% and 20.7%, respectively. For eso-deviation, the polychoric correlation was significantly greater in monozygotic (MZ) (r = 0.65) compared to dizygotic (DZ) twin pairs (r = 0.33), suggesting a genetic role (p = .003). There was no significant difference in polychoric correlation between MZ (r = 0.55) and DZ twin pairs (r = 0.53) for exo-deviation (p = .86), implying that genetic factors do not play a significant role in the etiology of exo-deviation. The heritability of an eso-deviation was 0.64 (95% CI 0.50-0.75). The additive genetic correlation for eso-deviation and refractive error was 0.13 and the bivariate heritability (i.e., shared variance) was less than 1%, suggesting negligible shared genetic effect. This study documents a substantial heritability of 64% for eso-deviation, yet no corresponding heritability for exo-deviation, suggesting that the genetic contribution to strabismus may be specific to eso-deviation. Future studies are now needed to identify the genes associated with eso-deviation and

  17. The Results of ESO/SRC Plates Survey of Southern Hemisphere

    Science.gov (United States)

    Gyulbudaghian, A. L.

    2017-07-01

    We have searched the ESO/SRC (E, B, R, J) charts of Southern Hemisphere for discovering of new star forming regions, cometary nebulae, HH objects, tight trapezium like systems, consisting of late type dwarf stars, jets from the stars, and also of radial systems of dark globules. This work was done in several places: in Estonia (Tartu observatory), in Mexico (Mexico, UNAM, Institute of Astronomy), in Chile (twice: ESO Vitacura, Cerro Calan Observatory, Santiago). As a result of this work several dozens of each mentioned above type of objects were found.

  18. South America Delegation of the European Parliament Visits ESO's Paranal Observatory

    Science.gov (United States)

    2003-10-01

    Chaired by Dr. Rolf Linkohr , Members of the European Parliament Delegation for Relations with the Countries of South America and MERCOSUR visited ESO's Paranal Observatory on October 29-30, 2003. As the world's most advanced optical/infrared astronomical facility, the ESO Very Large Telescope (VLT) at Paranal is the flagship of European astronomy and a powerful expression of Europe's ambitions in this important area of fundamental research. It is also an outstanding example of the capabilities of Europe's high-technology industries. At the same time, the Paranal Observatory provides a model for international, scientific co-operation between Europe and Latin America, based on agreements between ESO and the Republic of Chile. The deputies were accompanied by the ESO Representative in Chile, Mr. Daniel Hofstadt . Upon arrival Wednesday afternoon, the Delegation was welcomed by Dr. Roberto Gilmozzi , Director of ESO Paranal. The distinguished visitors were impressed by the instrumentation park available to astronomical research at Paranal. During a nightly visit to the Control Centre of the observatory, they met with visiting astronomers and ESO staff and experienced some of the exciting research programmes now being carried out with the VLT at the front line of human knowledge. For Dr. Linkohr , Astrophysics means high-tech today and it has many ramifications in other areas of Science and Technology. "Europe cannot be better represented in Latin America - and in Chile in particular - than by such an outstanding scientific and technical achievement as the VLT" , he said. ESO has received support from EU programmes. "Current interactions between ESO and the EU have shown that first-rate windows of opportunities exist in high-tech developments, indispensable for our continued exploration of the unknown" , indicated Dr. Gilmozzi . The deputies are leaving Paranal today (Thursday October 30th), continuing to La Serena before travelling back to Santiago de Chile. The

  19. PR-PR: cross-platform laboratory automation system.

    Science.gov (United States)

    Linshiz, Gregory; Stawski, Nina; Goyal, Garima; Bi, Changhao; Poust, Sean; Sharma, Monica; Mutalik, Vivek; Keasling, Jay D; Hillson, Nathan J

    2014-08-15

    To enable protocol standardization, sharing, and efficient implementation across laboratory automation platforms, we have further developed the PR-PR open-source high-level biology-friendly robot programming language as a cross-platform laboratory automation system. Beyond liquid-handling robotics, PR-PR now supports microfluidic and microscopy platforms, as well as protocol translation into human languages, such as English. While the same set of basic PR-PR commands and features are available for each supported platform, the underlying optimization and translation modules vary from platform to platform. Here, we describe these further developments to PR-PR, and demonstrate the experimental implementation and validation of PR-PR protocols for combinatorial modified Golden Gate DNA assembly across liquid-handling robotic, microfluidic, and manual platforms. To further test PR-PR cross-platform performance, we then implement and assess PR-PR protocols for Kunkel DNA mutagenesis and hierarchical Gibson DNA assembly for microfluidic and manual platforms.

  20. PR-PR: Cross-Platform Laboratory Automation System

    Energy Technology Data Exchange (ETDEWEB)

    Linshiz, G; Stawski, N; Goyal, G; Bi, CH; Poust, S; Sharma, M; Mutalik, V; Keasling, JD; Hillson, NJ

    2014-08-01

    To enable protocol standardization, sharing, and efficient implementation across laboratory automation platforms, we have further developed the PR-PR open-source high-level biology-friendly robot programming language as a cross-platform laboratory automation system. Beyond liquid-handling robotics, PR-PR now supports microfluidic and microscopy platforms, as well as protocol translation into human languages, such as English. While the same set of basic PR-PR commands and features are available for each supported platform, the underlying optimization and translation modules vary from platform to platform. Here, we describe these further developments to PR-PR, and demonstrate the experimental implementation and validation of PR-PR protocols for combinatorial modified Golden Gate DNA assembly across liquid-handling robotic, microfluidic, and manual platforms. To further test PR-PR cross-platform performance, we then implement and assess PR-PR protocols for Kunkel DNA mutagenesis and hierarchical Gibson DNA assembly for microfluidic and manual platforms.

  1. Prokaryotic expression, purification and identification of NY-ESO-1/GST fusion protein in E.coli%NY-ESO-1/GST融合蛋白在大肠杆菌的表达、纯化及鉴定

    Institute of Scientific and Technical Information of China (English)

    汤蕾; 宋朝君; 孙元杰; 李娜; 魏玉英; 孙奕; 杨琨

    2012-01-01

    AIM: To construct an expression plasmid for NY-ESO-1 gene and identify the expression of recombinant protein NY-ESO-1/GST in E. coli. METHODS: NY-ESO-1 segment was amplified from the testis cDNA library by RT-PCR and cloned into the prokaryotic expression vector pGEX4T-l downstream tagged by GST to construct the expression plasmid pGEX4Tl-NY-ESO-l. The recombinant vector was transformed to BL21 ( DE3) and NY-ESO-1/ GST fusion protein was induced expression by IPTG. The protein was purified by urea elution and identified by SDS-PAGE and Western blotting. RESULTS: The NY-ESO-1 segment was successfully amplified and its sequence was identical with that published in GenBank. The BL21 (DE3) pLysS containing the pGEX-Tl-NY-ESO-1 expressed a M, 44 000 fusion protein under the induction of IPTG. The purity of the protein was 90%. Western blotting proved that NY-ESO-1/GST had a specific reaction with anti-GST mAb. CONCLUSION; The prokaryotic expression vector of NY-ESO-1 has been constructed and the fusion protein NY-ESO-1/GST of high purity is successfully expressed.%目的:构建肿瘤-睾丸抗原NY-ESO-1与GST融合基因的原核表达载体,在大肠杆菌中表达并对融合蛋白NY-ESO-1/GST进行纯化和初步鉴定.方法:设计针对NY-ESO-1的特异性引物,采用聚合酶链反应(PCR)从睾丸组织的cDNA文库扩增NY-ESO-1基因片段,经上下游引物所引入的EcoR I和Xho I双酶切后克隆人原核表达载体pGEX-4T1中GST标签的下游,构建重组表达载体pGEX-4T1-NY-ESO-1,并将该载体转化大肠杆菌BL21( DE3) pLysS中,IPTG诱导表达NYESO-1/GST融合蛋白,经不同浓度尿素洗脱纯化后,表达产物通过SDS-PAGE和Western blot法进行鉴定.结果:重组质粒经限制性内切酶EcoR I和Xho I双酶切鉴定和IPTG诱导表达NY-ESO-1/GST的SDS-PAGE分析表明,表达产物的相对分子质量(Mr)为44000,与理论值相符,并主要以包涵体形式存在,灰度扫描分析显示融合蛋白表

  2. La civilización romana como recurso CLIL en el aula de Ciencias Sociales (1º ESO)

    OpenAIRE

    Vergano Villodres, Paola

    2014-01-01

    La civilización romana como recurso CLIL en el aula de Ciencias Sociales (1º ESO)es un proyecto en el cual se desarrollan una serie de actividades para trabajar la Historia de Roma a partir de la metodología CLIL y la lengua inglesa.

  3. The Gaia-ESO Survey: processing of the FLAMES-UVES spectra

    CERN Document Server

    Sacco, G G; Franciosini, E; Maiorca, E; Randich, S; Modigliani, A; Gilmore, G; Asplund, M; Binney, J; Bonifacio, P; Drew, J; Feltzing, S; Ferguson, A; Jeffries, R; Micela, G; Negueruela, I; Prusti, T; Rix, H -W; Vallenari, A; Alfaro, E; Prieto, C Allende; Babusiaux, C; Bensby, T; Blomme, R; Bragaglia, A; Flaccomio, E; Francois, P; Hambly, N; Irwin, M; Koposov, S; Korn, A; Lanzafame, A; Pancino, E; Recio-Blanco, A; Smiljanic, R; Van Eck, S; Walton, N; Bergemann, M; Costado, M T; de Laverny, P; Heiter, U; Hill, V; Hourihane, A; Jackson, R; Jofre, P; Lewis, J; Lind, K; Lardo, C; Magrini, L; Masseron, T; Prisinzano, L; Worley, C

    2014-01-01

    The Gaia-ESO Survey is a large public spectroscopic survey that aims to derive radial velocities and fundamental parameters of about 10^5 Milky Way stars in the field and in clusters. Observations are carried out with the multi-object optical spectrograph FLAMES, using simultaneously the medium resolution (R~20,000) GIRAFFE spectrograph and the high resolution (R~47,000) UVES spectrograph. In this paper, we describe the methods and the software used for the data reduction, the derivation of the radial velocities, and the quality control of the FLAMES-UVES spectra. Data reduction has been performed using a workflow specifically developed for this project. This workflow runs the ESO public pipeline optimizing the data reduction for the Gaia-ESO Survey, performs automatically sky subtraction, barycentric correction and normalisation, and calculates radial velocities and a first guess of the rotational velocities. The quality control is performed using the output parameters from the ESO pipeline, by a visual insp...

  4. Automatic parameter extraction for the 16,000 galaxies in the ESO/Uppsala catalogue

    NARCIS (Netherlands)

    Lauberts, A.; Valentijn, E. A.

    1983-01-01

    Under a restriction for minimum angular diameter of not less than 1 arcmin, corresponding to the 15th magnitude and allowing morphological classification of structure, 16,000 galaxies have been brought together in the single volume of the ESO/Uppsala catalog (1982). Attention is given to the automat

  5. Extinction in the Galaxy from surface brightnesses of ESO-LV galaxies : Testing "standard" extinction maps

    NARCIS (Netherlands)

    Choloniewski, J.; Valentijn, E. A.

    2003-01-01

    A new method for the determination of the extinction in the Galaxy is proposed. The method uses surface brightnesses of external galaxies in the B and R-bands. The observational data have been taken from the ESO-LV galaxy catalog. As a first application of our model we derive the ratio of R-band to

  6. ASASSN-16kz: Discovery of A Probable Supernova in ESO 555-G029

    Science.gov (United States)

    Holoien, T. W.-S.; Stanek, K. Z.; Kochanek, C. S.; Brown, J. S.; Shields, J.; Shappee, B. J.; Prieto, J. L.; Bersier, D.; Dong, Subo; Bose, S.; Chen, Ping; Brimacombe, J.

    2016-09-01

    During the ongoing All Sky Automated Survey for SuperNovae (ASAS-SN or "Assassin"), using data from the quadruple 14-cm "Cassius" telescope in Cerro Tololo, Chile, we discovered a new transient source, most likely a supernova, in the galaxy ESO 555-G029.

  7. X-shooter, the new wide band intermediate resolution spectrograph at the ESO Very Large Telescope

    DEFF Research Database (Denmark)

    Vernet, J.; Dekker, H.; D'Odorico, S.

    2011-01-01

    X-shooter is the first 2nd generation instrument of the ESO Very Large Telescope (VLT). It is a very efficient, single-target, intermediate-resolution spectrograph that was installed at the Cassegrain focus of UT2 in 2009. The instrument covers, in a single exposure, the spectral range from 300 t...

  8. X-shooter, the new wide band intermediate resolution spectrograph at the ESO Very Large Telescope

    NARCIS (Netherlands)

    Vernet, J.; Dekker, H.; D'Odorico, S.; Kaper, L.; Kjaergaard, P.; Hammer, F.; Randich, S.; Zerbi, F.; Groot, P.J.; Hjorth, J.; Guinouard, I.; Navarro, R.; Adolfse, T.; Albers, P.W.; Amans, J.-P.; Andersen, J.J.; Andersen, M.I.; Binetruy, P.; Bristow, P.; Castillo, R.; Chemla, F.; Christensen, L.; Conconi, P.; Conzelmann, R.; Dam, J.; De Caprio, V.; de Ugarte Postigo, A.; Delabre, B.; Di Marcantonio, P.; Downing, M.; Elswijk, E.; Finger, G.; Fischer, G.; Flores, H.; François, P.; Goldoni, P.; Guglielmi, L.; Haigron, R.; Hanenburg, H.; Hendriks, I.; Horrobin, M.; Horville, D.; Jessen, N.C.; Kerber, F.; Kern, L.; Kiekebusch, M.; Kleszcz, P.; Klougart, J.; Kragt, J.; Larsen, H.H.; Lizon, J.-L.; Lucuix, C.; Mainieri, V.; Manuputy, R.; Martayan, C.; Mason, E.; Mazzoleni, R.; Michaelsen, N.; Modigliani, A.; Moehler, S.; Møller, P.; Norup Sørensen, A.; Nørregaard, P.; Péroux, C.; Patat, F.; Pena, E.; Pragt, J.; Reinero, C.; Rigal, F.; Riva, M.; Roelfsema, R.; Royer, F.; Sacco, G.; Santin, P.; Schoenmaker, T.; Spano, P.; Sweers, E.; ter Horst, R.; Tintori, M.; Tromp, N.; van Dael, P.; van Vliet, H.; Venema, L.; Vidali, M.; Vinther, J.; Vola, P.; Winters, R.; Wistisen, D.; Wulterkens, G.; Zacchei, A.

    2011-01-01

    X-shooter is the first 2nd generation instrument of the ESO Very Large Telescope (VLT). It is a very efficient, single-target, intermediate-resolution spectrograph that was installed at the Cassegrain focus of UT2 in 2009. The instrument covers, in a single exposure, the spectral range from 300 to

  9. ASASSN-17hp: Discovery of A Probable Supernova in ESO 575-G066

    Science.gov (United States)

    Fernandez, J. M.; Cacella, P.; Brimacombe, J.; Brown, J. S.; Stanek, K. Z.; Holoien, T. W.-S.; Kochanek, C. S.; Shields, J.; Thompson, T. A.; Shappee, B. J.; Prieto, J. L.; Bersier, D.; Dong, Subo; Bose, S.; Chen, Ping; Nicholls, B.

    2017-06-01

    During the ongoing All Sky Automated Survey for SuperNovae (ASAS-SN, Shappee et al. 2014), using data from the quadruple 14-cm "Cassius" telescope in Cerro Tololo, Chile, we discovered a new transient source, most likely a supernova, in the galaxy ESO 575-G066.

  10. ASASSN-17hk: Discovery of A Bright Nuclear Transient in ESO 092-G014

    Science.gov (United States)

    Brown, J. S.; Stanek, K. Z.; Holoien, T. W.-S.; Kochanek, C. S.; Shields, J.; Thompson, T. A.; Shappee, B. J.; Prieto, J. L.; Bersier, D.; Dong, Subo; Bose, S.; Chen, Ping; Brimacombe, J.

    2017-06-01

    During the ongoing All Sky Automated Survey for SuperNovae (ASAS-SN, Shappee et al. 2014), using data from the quadruple 14-cm "Cassius" telescope in Cerro Tololo, Chile, we discovered a new transient source, most likely a supernova, in the galaxy ESO 092-G014.

  11. European Stroke Organisation (ESO) guidelines for the management of spontaneous intracerebral hemorrhage

    DEFF Research Database (Denmark)

    Steiner, Thorsten; Al-Shahi Salman, Rustam; Beer, Ronnie

    2014-01-01

    BACKGROUND: Intracerebral hemorrhage (ICH) accounted for 9% to 27% of all strokes worldwide in the last decade, with high early case fatality and poor functional outcome. In view of recent randomized controlled trials (RCTs) of the management of ICH, the European Stroke Organisation (ESO) has upd...

  12. Automatic parameter extraction for the 16,000 galaxies in the ESO/Uppsala catalogue

    NARCIS (Netherlands)

    Lauberts, A.; Valentijn, E. A.

    1983-01-01

    Under a restriction for minimum angular diameter of not less than 1 arcmin, corresponding to the 15th magnitude and allowing morphological classification of structure, 16,000 galaxies have been brought together in the single volume of the ESO/Uppsala catalog (1982). Attention is given to the

  13. The Cepheid distance to NGC 5236 (M83) with the ESO Very Large Telescope

    NARCIS (Netherlands)

    Thim, F; Tammann, GA; Saha, A; Dolphin, A; Sandage, A; Tolstoy, E; Labhardt, L

    2003-01-01

    Cepheids have been observed in NGC 5236 (M83) using the Antu (Unit Telescope 1) 8.2 m telescope of the ESO Very Large Telescope with the Focal Reducer/Low Dispersion Spectrograph 1. Repeated imaging observations have been made between 2000 January and 2001 July. Images were obtained in 34 epochs in

  14. Athermal design of the optical tube assemblies for the ESO VLT four laser guidestar facility

    NARCIS (Netherlands)

    Henselmans, R.; Nijkerk, M.D.; Lemmen, M.H.J.; Rijnveld, N.; Kamphues, F.G.

    2011-01-01

    TNO is developing the Optical Tube Asssemblies (OTAs) for the ESO VLT Four Laser Guide Star Facility. The OTAs are Galilean 20x beam expanders, expanding a Ø15 mm input beam to a steerable Ø300 mm output beam with a wavefront quality requirement of 50 nm rms. The allowed defocus under the influence

  15. The Gaia-ESO Survey: A simple explanation for the Li-rich giant problem

    DEFF Research Database (Denmark)

    Casey, Andrew R.; Ruchti, G.; Masseron, T.;

    2016-01-01

    observed through the Gaia-ESO Survey. Our sample is one of the largest in the literature, and includes nine towards the CoRoT fields. We explore all mechanisms proposed to explain Li-rich giants. While the planet accretion scenario was presented to reconcile observations of Li-rich giants across the RGB...

  16. VIDEO AT OSF - Interview to David Rabanus, ESO, on the ALMA OSF site, at 2900 m

    CERN Multimedia

    2015-01-01

    In this interview, recorded on the ALMA OSF (Operations and Support Facilities) site, at 2900 m on the Chajnantor highlands, physicist David Rabanus of ESO/ ALMA takes us inside the heart of the ALMA antennas, to reveal how the antennas detect millimetric and submillimetric radiowaves.

  17. Tumor-infiltrating T cells correlate with NY-ESO-1-specific autoantibodies in ovarian cancer.

    Directory of Open Access Journals (Sweden)

    Katy Milne

    Full Text Available BACKGROUND: Tumor-infiltrating CD8+ T cells are correlated with prolonged progression-free and overall survival in epithelial ovarian cancer (EOC. A significant fraction of EOC patients mount autoantibody responses to various tumor antigens, however the relationship between autoantibodies and tumor-infiltrating T cells has not been investigated in EOC or any other human cancer. We hypothesized that autoantibody and T cell responses may be correlated in EOC and directed toward the same antigens. METHODOLOGY AND PRINCIPAL FINDINGS: We obtained matched serum and tumor tissue from 35 patients with high-grade serous ovarian cancer. Serum samples were assessed by ELISA for autoantibodies to the common tumor antigen NY-ESO-1. Tumor tissue was examined by immunohistochemistry for expression of NY-ESO-1, various T cell markers (CD3, CD4, CD8, CD25, FoxP3, TIA-1 and Granzyme B and other immunological markers (CD20, MHC class I and MHC class II. Lymphocytic infiltrates varied widely among tumors and included cells positive for CD3, CD8, TIA-1, CD25, FoxP3 and CD4. Twenty-six percent (9/35 of patients demonstrated serum IgG autoantibodies to NY-ESO-1, which were positively correlated with expression of NY-ESO-1 antigen by tumor cells (r = 0.57, p = 0.0004. Autoantibodies to NY-ESO-1 were associated with increased tumor-infiltrating CD8+, CD4+ and FoxP3+ cells. In an individual HLA-A2+ patient with autoantibodies to NY-ESO-1, CD8+ T cells isolated from solid tumor and ascites were reactive to NY-ESO-1 by IFN-gamma ELISPOT and MHC class I pentamer staining. CONCLUSION AND SIGNIFICANCE: We demonstrate that tumor-specific autoantibodies and tumor-infiltrating T cells are correlated in human cancer and can be directed against the same target antigen. This implies that autoantibodies may collaborate with tumor-infiltrating T cells to influence clinical outcomes in EOC. Furthermore, serological screening methods may prove useful for identifying clinically relevant

  18. A potential role for immunotherapy in thyroid cancer by enhancing NY-ESO-1 cancer antigen expression.

    Science.gov (United States)

    Gunda, Viswanath; Frederick, Dennie T; Bernasconi, Maria J; Wargo, Jennifer A; Parangi, Sareh

    2014-08-01

    NY-ESO-1 is one of the most immunogenic members of the cancer/testis antigen family and its levels can be increased after exposure to demethylating and deacetylating agents. This cytoplasmic antigen can serve as a potent target for cancer immunotherapy and yet has not been well studied in differentiated thyroid cancer cells. We studied the baseline expression of NY-ESO-1 messenger RNA and protein before and after exposure to 5-aza-2'-deoxycytidine (DAC) (72 hours) in a panel of thyroid cancer cell lines using quantitative polymerase chain reaction and Western blot. HLA-A2+, NY-ESO-1+ thyroid cell lines were then co-cultured with peripheral blood lymphocytes transduced with NY-ESO-1 specific T-cell receptor (TCR) and assayed for interferon-gamma and Granzyme-B release in the medium. SCID mice injected orthotopically with BCPAP cells were treated with DAC to evaluate for NY-ESO-1 gene expression in vivo. None of the thyroid cancer cell lines showed baseline expression of NY-ESO-1. Three cell lines, BCPAP, TPC-1, and 8505c, showed an increase in NY-ESO-1 gene expression with DAC treatment and were found to be HLA-A2 positive. DAC-treated target BCPAP and TPC-1 tumor cells with up-regulated NY-ESO-1 levels were able to mount an appropriate interferon-gamma and Granzyme-B response upon co-culture with the NY-ESO-1-TCR-transduced peripheral blood lymphocytes. In vivo DAC treatment was able to increase NY-ESO-1 expression in an orthotopic mouse model with BCPAP cells. Our data suggest that many differentiated thyroid cancer cells can be pressed to express immune antigens, which can then be utilized in TCR-based immunotherapeutic interventions.

  19. Neutron Scattering from fcc Pr and Pr3Tl

    DEFF Research Database (Denmark)

    Birgeneau, R. J.; Als-Nielsen, Jens Aage; Bucher, E.

    1972-01-01

    Elastic-neutron-scattering measurements on the singlet-ground-state ferromagnets fcc Pr and Pr3 Tl are reported. Both exhibit magnetic phase transitions, possibly to a simple ferromagnetic state at 20 and 11.6 °K, respectively. The transitions appear to be of second order although that in fcc Pr...... is clearly anomalous. Additional information on the inelastic scattering studies of the Γ1-Γ4 excitons in these systems is presented. dhcp Pr is also briefly discussed....

  20. ESO unveils an amazing, interactive, 360-degree panoramic view of the entire night sky

    Science.gov (United States)

    2009-09-01

    The first of three images of ESO's GigaGalaxy Zoom project - a new magnificent 800-million-pixel panorama of the entire sky as seen from ESO's observing sites in Chile - has just been released online. The project allows stargazers to explore and experience the Universe as it is seen with the unaided eye from the darkest and best viewing locations in the world. This 360-degree panoramic image, covering the entire celestial sphere, reveals the cosmic landscape that surrounds our tiny blue planet. This gorgeous starscape serves as the first of three extremely high-resolution images featured in the GigaGalaxy Zoom project, launched by ESO within the framework of the International Year of Astronomy 2009 (IYA2009). GigaGalaxy Zoom features a web tool that allows users to take a breathtaking dive into our Milky Way. With this tool users can learn more about many different and exciting objects in the image, such as multicoloured nebulae and exploding stars, just by clicking on them. In this way, the project seeks to link the sky we can all see with the deep, "hidden" cosmos that astronomers study on a daily basis. The wonderful quality of the images is a testament to the splendour of the night sky at ESO's sites in Chile, which are the most productive astronomical observatories in the world. The plane of our Milky Way Galaxy, which we see edge-on from our perspective on Earth, cuts a luminous swath across the image. The projection used in GigaGalaxy Zoom place the viewer in front of our Galaxy with the Galactic Plane running horizontally through the image - almost as if we were looking at the Milky Way from the outside. From this vantage point, the general components of our spiral galaxy come clearly into view, including its disc, marbled with both dark and glowing nebulae, which harbours bright, young stars, as well as the Galaxy's central bulge and its satellite galaxies. The painstaking production of this image came about as a collaboration between ESO, the renowned

  1. Préface

    Directory of Open Access Journals (Sweden)

    Marguerite Mendell

    2008-12-01

    Full Text Available C’est avec grand plaisir que je contribue la préface de ce numéro d’Interventions économiques dédié à la pertinence de la pensée de Karl Polanyi au début du 21ème siècle. Je suis très reconnaissante aux éditeurs, Diane Gabrielle Tremblay, Jean-Marc Fontan et Jean Louis Laville d’avoir pris l’initiative de préparer ce numéro pour le 11ème colloque international de l’Institut Karl Polanyi, qui correspond aussi au 20ème anniversaire de l’Institut, établi à l’Université Concordia en 1988. Interve...

  2. 重组腺病毒载体pAd-NY-ESO-1-EGFP的构建及鉴定%Construction and Identification of Recombinant Adenovirns Vector Containing NY-ESO-1 Gene

    Institute of Scientific and Technical Information of China (English)

    张又莉; 徐少勇; 王家宁; 黄永章; 王斌; 宋军; 郭凌郧

    2008-01-01

    目的:利用细菌内同源重组法构建含人肿瘤特异性抗原的腺病毒质粒.方法:设计NY-ESO-1 cDNA扩增引物,从pETl5b-NY-ESO-1质粒中扩增NY-ESO-1的DNA序列,与pShuttle-IRES-hrGFP-2进行连接,PCR和EcoRV酶切鉴定重组质粒pShuttle-NY-ESO-1-EGFP,经Pme I酶切线性化后,转化含pAdeasy-1的超感受态BJ5183大肠杆菌,细菌内同源重组法构建腺病毒质粒pAd-NY-ESO-1-EGFP;质粒经Pac I酶切鉴定,DNA测序.结果:线性化的pShuttle-NY-ESO-1-EGFP转化含pAdeasy-1的超感受态BJ5183大肠杆菌,重组质粒经酶切获得一大于23 kb的大片段和4.5kb的片段,PCR反应扩增出了340 bp的片段.结论:用细菌内同源重组法成功地构建了含NY-ESO-1的重组腺病毒质粒,为进行表达NY-ESO-1的重组腺病毒的制备及肿瘤特异性抗原NY-ESO-1的核酸疫苗在肿瘤方面的研究奠定了基础.

  3. Toma de impresiones en prótesis fija: implicaciones periodontales

    OpenAIRE

    2016-01-01

    Uno de los principales éxitos en prostodoncia es la exactitud de la restauración final que garantice la sobrevida de las prótesis, la reproducción precisa de márgenes de la preparación en una impresión es un requisito necesario para lograr una buena calidad marginal. Es por eso que la técnica y material de impresión, así como el manejo de los tejidos periodontales resultan claves en la consecución del éxito. Entender las propiedades de cada uno de los materiales utilizados durante el proceso ...

  4. Toma de impresiones en prótesis fija: implicaciones periodontales

    OpenAIRE

    H. Aldana Sepúlveda; H. Garzón Rayo

    2016-01-01

    Uno de los principales éxitos en prostodoncia es la exactitud de la restauración final que garantice la sobrevida de las prótesis, la reproducción precisa de márgenes de la preparación en una impresión es un requisito necesario para lograr una buena calidad marginal. Es por eso que la técnica y material de impresión, así como el manejo de los tejidos periodontales resultan claves en la consecución del éxito. Entender las propiedades de cada uno de los materiales utilizados durante el proceso ...

  5. Prácticas y comportamientos sexuales de estudiantes de la Universidad de Manizales (Colombia) 2010

    OpenAIRE

    2010-01-01

    Antecedentes: La población universitaria es vulnerable, por eso indagar sobre las prácticas y comportamientos sexuales es una conducta adecuada, ya que comportamientos positivos pueden desarrollar mejores habilidades para la prevención de conductas de alto riesgo, mayor satisfacción sexual y por ende una vida más plena. Mate-riales y métodos: Estudio tipo corte transversal, donde participaron estudiantes de todas las facultades de la universidad de Manizales (Caldas, Colombia), que se encontr...

  6. China PR Industry Report 2005

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    @@ Background The 2005 annual survey on the PR industry in China was conducted by China International Public Relations Association(CIPRA)from January 20the to February 20th ,in order to better reflect the development of the PR service market in China,investigate trends within the PR industry,and promote its continuous development.

  7. 人NY-ESO-1基因的原核表达、纯化和初步应用%The Prokaryotic Expression, Purification and Preliminary Application of Human NY-ESO-1 Gene

    Institute of Scientific and Technical Information of China (English)

    张文敏; 肖刚; 张萌; 谢丹; 郭爱林; 文剑明

    2005-01-01

    目的:克隆人NY-ESO-1基因,进行原核表达和分离纯化,并初步应用于肝癌患者血清NY-ESO-1抗体的检测.方法:通过RT-PCR技术从人肝癌组织中扩增NY-ESO-1基因片段,插入原核表达载体pGEX4T-1(+)中,构建重组表达质粒pGEX/ESO1,导入大肠杆菌BL21(DE3),诱导目的蛋白表达,经包涵体透析复性和GSTrap亲和层析纯化目的蛋白,Western blot鉴定.应用间接ELISA方法初步检测50例肝癌患者血清和20例正常人血清NY-ESO-1抗体的表达.结果:扩增得到NY-ESO-1基因3'端276bp片段,与GeneBank公布序列一致,构建的pGEX/ESO1原核表达质粒经IPTG诱导,在大肠杆菌中表达分子量约36kD的GST-ESO1融合蛋白,纯化后蛋白纯度为90%.50例肝细胞癌患者血清中4例检测到NY-ESO-1抗体(8%),正常人血清均为阴性.结论:成功构建pGEX/ESO1重组表达质粒,得到有活性的NY-ESO-1融合蛋白,对肝癌患者血清NY-ESO-1抗体的检测有一定的应用价值.

  8. Polymeric Structure and Host Toll-like Receptor 4 Dictate Immunogenicity of NY-ESO-1 Antigen in Vivo*

    Science.gov (United States)

    Liu, Yanan; Tian, Xiaoli; Leitner, Wolfgang W.; Aldridge, Michael E.; Zheng, Junying; Yu, Zhiya; Restifo, Nicholas P.; Weiss, Richard; Scheiblhofer, Sandra; Xie, Chong; Sun, Ren; Cheng, Genhong; Zeng, Gang

    2011-01-01

    In search of intrinsic factors that contribute to the distinctively strong immunogenicity of a non-mutated cancer/testis antigen, we found that NY-ESO-1 forms polymeric structures through disulfide bonds. NY-ESO-1 binding to immature dendritic cells was dependent on its polymeric structure and involved Toll-like receptor-4 (TLR4) on the surface of immature dendritic cells in mouse and human. Gene gun-delivered plasmid encoding the wild-type NY-ESO-1 readily induced T cell-dependent antibody (Ab) responses in wild-type C57BL/10 mice but not TLR4-knock-out C57BL/10ScNJ mice. Disrupting polymeric structures of NY-ESO-1 by cysteine-to-serine (Cys-to-Ser) substitutions lead to diminished immunogenicity and altered TLR4-dependence in the induced Ab response. To demonstrate its adjuvant effect, NY-ESO-1 was fused with a major mugwort pollen allergen Art v 1 and a tumor-associated antigen, carbonic anhydrase 9. Plasmid DNA vaccines encoding the fusion genes generated robust immune responses against otherwise non-immunogenic targets in mice. Polymeric structure and TLR4 may play important roles in rendering NY-ESO-1 immunogenic and thus serve as a potent molecular adjuvant. NY-ESO-1 thus represents the first example of a cancer/testis antigen that is a also damage-associated molecular pattern. PMID:21900253

  9. Polymeric structure and host Toll-like receptor 4 dictate immunogenicity of NY-ESO-1 antigen in vivo.

    Science.gov (United States)

    Liu, Yanan; Tian, Xiaoli; Leitner, Wolfgang W; Aldridge, Michael E; Zheng, Junying; Yu, Zhiya; Restifo, Nicholas P; Weiss, Richard; Scheiblhofer, Sandra; Xie, Chong; Sun, Ren; Cheng, Genhong; Zeng, Gang

    2011-10-28

    In search of intrinsic factors that contribute to the distinctively strong immunogenicity of a non-mutated cancer/testis antigen, we found that NY-ESO-1 forms polymeric structures through disulfide bonds. NY-ESO-1 binding to immature dendritic cells was dependent on its polymeric structure and involved Toll-like receptor-4 (TLR4) on the surface of immature dendritic cells in mouse and human. Gene gun-delivered plasmid encoding the wild-type NY-ESO-1 readily induced T cell-dependent antibody (Ab) responses in wild-type C57BL/10 mice but not TLR4-knock-out C57BL/10ScNJ mice. Disrupting polymeric structures of NY-ESO-1 by cysteine-to-serine (Cys-to-Ser) substitutions lead to diminished immunogenicity and altered TLR4-dependence in the induced Ab response. To demonstrate its adjuvant effect, NY-ESO-1 was fused with a major mugwort pollen allergen Art v 1 and a tumor-associated antigen, carbonic anhydrase 9. Plasmid DNA vaccines encoding the fusion genes generated robust immune responses against otherwise non-immunogenic targets in mice. Polymeric structure and TLR4 may play important roles in rendering NY-ESO-1 immunogenic and thus serve as a potent molecular adjuvant. NY-ESO-1 thus represents the first example of a cancer/testis antigen that is a also damage-associated molecular pattern.

  10. Preclinical safety pharmacology study of a novel protein-based cancer vaccine CHP-NY-ESO-1.

    Science.gov (United States)

    Harada, Naozumi; Hoshiai, Kiyotaka; Takahashi, Yoshiyasu; Sakaguchi, Yasue; Kuno, Takayoshi; Hishida, Tadashi; Shiku, Hiroshi

    2008-05-23

    CHP-NY-ESO-1 is a novel therapeutic cancer vaccine consisting of a recombinant protein of cancer antigen NY-ESO-1 and a polysaccharide-based delivery system, cholesteryl pullulan. A pilot clinical study of CHP-NY-ESO-1 in cancer patients was previously conducted, and the adverse events related to this drug were observed to be limited to skin reactions at injection sites. To further establish the safety of CHP-NY-ESO-1, we studied the effects of its subcutaneous injection on vital functions such as the central nervous system, cardiovascular system and respiratory system using preclinical animal models. The effects of CHP-NY-ESO-1 on the cardiovascular system were investigated in dogs using a telemetry system for blood pressure and heart rate and the Holter monitoring for ambulatory electrocardiograms. No drug-related changes were observed in these parameters. The effect of CHP-NY-ESO-1 on the hERG-dependent potassium currents was also examined using in vitro cultured cell system, and no inhibition of hERG currents was observed. The effects of CHP-NY-ESO-1 on the central nervous system were examined in rats using functional observational battery method, and no drug-related changes were observed in home cage observations, open field observations, hand held observations, and perception and motor function observations. The effect of CHP-NY-ESO-1 on the respiratory system was investigated in rats by measuring tidal volume, minute volume and respiratory rate using whole-body plethysmograph method, and no significant changes were found in these parameters. These results indicate that CHP-NY-ESO-1 would not have any pharmacological effects on vital functions and support the safety of this cancer vaccine for clinical use.

  11. Enhancing whole-tumor cell vaccination by engaging innate immune system through NY-ESO-1/dendritic cell interactions.

    Science.gov (United States)

    Xu, Le; Zheng, Junying; Nguyen, David H; Luong, Quang T; Zeng, Gang

    2013-10-01

    NY-ESO-1 is a cancer/germline antigen (Ag) with distinctively strong immunogenicity. We have previously demonstrated that NY-ESO-1 serves as an endogenous adjuvant by engaging dendritic cell (DC)-surface receptors of calreticulin (CRT) and toll-like receptor (TLR) 4. In the present study, NY-ESO-1 was investigated for its immunomodulatory roles as a molecular adjuvant in whole-tumor cell vaccines using the Renca kidney cancer model. Renca cells were genetically engineered to express NY-ESO-1 on the cell surface to enhance direct interactions with DC. The effect of ectopic cell-surface expression of NY-ESO-1 was investigated on tumor immunogenicity, DC activation, cytotoxic T lymphocytes against model tumor-associated Ags, and the effectiveness of the modified tumor cells as a therapeutic whole-cell vaccine. Cell-surface expression of NY-ESO-1 was able to reduce the tumor growth of Renca cells in BALB/c mice, although the modification did not alter cell proliferation rate in vitro. Directly engaging the innate immune system through NY-ESO-1 facilitated the interaction of tumor cells with DC, leading to enhanced DC activation and subsequent tumor-specific T-cell priming. When used as a therapeutic whole-cell vaccine, Renca cells with NY-ESO-1 on the surface mediated stronger inhibitory effects on tumor growth and metastasis compared with parental Renca or Renca cells expressing a control protein GFP on the surface. Augmented antitumor efficacy correlated with increased CD8 T-cell infiltration into tumors and decreased myeloid-derived suppressor cells and regulatory T cells in the spleen. As a cancer/germline Ag and as an immunomodulatory adjuvant through engaging innate immune receptors, NY-ESO-1 offers a unique opportunity for improved whole-tumor cell vaccinations upon the classic GM-CSF-engineered cell vaccines.

  12. NY-ESO-1 is a ubiquitous immunotherapeutic target antigen for patients with myxoid/round cell liposarcoma.

    Science.gov (United States)

    Pollack, Seth M; Jungbluth, Achim A; Hoch, Benjamin L; Farrar, Erik A; Bleakley, Marie; Schneider, David J; Loggers, Elizabeth T; Rodler, Eve; Eary, Janet F; Conrad, Ernest U; Jones, Robin L; Yee, Cassian

    2012-09-15

    Myxoid/round cell liposarcoma (MRCL) is the second most common liposarcoma subtype, accounting for >33% of liposarcomas and approximately 10% of all soft tissue sarcomas. Although MRCL is a chemosensitive subtype, patients with metastatic disease have a poor outcome. NY-ESO-1 is a cancer-testis antigen (also known as cancer germ cell antigen) that has been successfully targeted in vaccine trials and in adoptive T-cell therapy trials for the treatment of several solid tumors. The authors investigated the feasibility of targeting NY-ESO-1 in patients with MRCL by evaluating the prevalence of NY-ESO-1 expression in tumors using immunohistochemistry and quantitative reverse transcriptase-polymerase chain reaction analysis. NY-ESO-1-specific tumor recognition by NY-ESO-1-specific T-cells also was analyzed using a chromium release assay. A search of the University of Washington Sarcoma Tissue Bank identified paraffin-embedded tumor samples from 25 patients with MRCL. NY-ESO-1 expression was observed in every MRCL tumor assessed (100%); in 18 tumors (72%), staining was homogenous. In all but 2 tumors, staining was sufficiently robust (2+) that such patients would be eligible for clinical trials of NY-ESO-1-directed therapy. By using NY-ESO-1 specific, CD8-positive T-cells, the in vitro sensitivity of myxoid liposarcoma cell lines to antigen-specific lysis was demonstrated. The current results establish NY-ESO-1 as an important target antigen for the treatment of patients with MRCL. Copyright © 2012 American Cancer Society.

  13. Effector memory and central memory NY-ESO-1-specific re-directed T cells for treatment of multiple myeloma.

    Science.gov (United States)

    Schuberth, P C; Jakka, G; Jensen, S M; Wadle, A; Gautschi, F; Haley, D; Haile, S; Mischo, A; Held, G; Thiel, M; Tinguely, M; Bifulco, C B; Fox, B A; Renner, C; Petrausch, U

    2013-04-01

    The cancer-testis antigen NY-ESO-1 is a potential target antigen for immune therapy expressed in a subset of patients with multiple myeloma. We generated chimeric antigen receptors (CARs) recognizing the immunodominant NY-ESO-1 peptide 157-165 in the context of HLA-A*02:01 to re-direct autologous CD8(+) T cells towards NY-ESO-1(+) myeloma cells. These re-directed T cells specifically lysed NY-ESO-1(157-165)/HLA-A*02:01-positive cells and secreted IFNγ. A total of 40% of CCR7(-) re-directed T cells had an effector memory phenotype and 5% a central memory phenotype. Based on CCR7 cell sorting, effector and memory CAR-positive T cells were separated and CCR7(+) memory cells demonstrated after antigen-specific re-stimulation downregulation of CCR7 as sign of differentiation towards effector cells accompanied by an increased secretion of memory signature cytokines such as IL-2. To evaluate NY-ESO-1 as potential target antigen, we screened 78 bone marrow biopsies of multiple myeloma patients where NY-ESO-1 protein was found to be expressed by immunohistochemistry in 9.7% of samples. Adoptively transferred NY-ESO-1-specific re-directed T cells protected mice against challenge with endogenously NY-ESO-1-positive myeloma cells in a xenograft model. In conclusion, re-directed effector- and central memory T cells specifically recognized NY-ESO-1(157-165)/ HLA-A*02:01-positive cells resulting in antigen-specific functionality in vitro and in vivo.

  14. ESO 243-49 HLX-1: scaling of X-ray spectral properties and black hole mass determination

    OpenAIRE

    Titarchuk, Lev; Seifina, Elena

    2016-01-01

    We report the results of Swift/XRT observations (2008-2015) of a hyper-luminous X-ray source, ESO 243-49 HLX-1. We found a strong observational evidence that ESO 243-49 HLX-1 underwent spectral transitions from the low/hard state to the high/soft state during these observations. The spectra of ESO 243-49 HLX-1 are well fitted by the so-{called} bulk motion Comptonization model for all spectral states. We have established the photon index Gamma saturation level, Gamma_{sat}$=3.0+/-0.1, in the ...

  15. The ESO-MIM Star Trek: A broadbased public oriented short interactive exhibition for an introduction to contemporary astrophysics

    Science.gov (United States)

    Marco, O.; Miranda, F.

    2005-12-01

    In the course of the European Southern Observatory (ESO) Public Relations work in Chile, we have created a permanent exhibition of astronomy for a broad section of the public in the Museo Interactivo Mirador-MIM (Interactive Museum of science, Chile), a collaboration between ESO and MIM. This Museum is mostly directed towards schoolchildren (7-14 years old), with adult visits at weekends. It is funded by public money and is unique in Chile. We decided to present the most recent questions relative to astronomy, based on pictures taken mostly at ESO observatories, and to skip the basics of astronomy that are taught at school.

  16. MAGE-A3/4 and NY-ESO-1 antigens expression in metastatic esophageal squamous cell carcinoma.

    Science.gov (United States)

    Bujas, T; Marusic, Z; Peric Balja, M; Mijic, A; Kruslin, B; Tomas, D

    2011-03-21

    In the present study we analyzed immunohistochemical expression of MAGE-A 3/4 and NY-ESO-1 in 55 samples of esophageal squamous cell carcinomas (ESCC) and their respective lymph node metastases. To our knowledge this is the first study to assess and compare the expression of these antigens in ESCC lymph node metastases. Fifty (90.9%) primary ESCC were positive for MAGE-A 3/4 and 53 (96.6%) were positive for NY-ESO-1. MAGE-A 3/4 was expressed in all lymph node metastases and the intensity of expression was high in a majority of cases. NY-ESO-1 was negative in 2 (7.1%) lymph nodes metastases, while the reaction was predominantly moderate in the positive group. In primary tumors MAGE-A 3/4 showed a significantly higher intensity of expression compared to NY-ESO-1 (P=0.047), while in lymph node metastases the intensity of expression was not significantly different (P=0.387). Primary tumors with and without lymph node metastases showed no significant differences in MAGE-A 3/4 (P=0.672) and NY-ESO-1 (P=0.444) expression. Intensity of MAGE-A 3/4 (P=0.461) and NY-ESO-1 (P=0.414) expression in primary tumors was not significantly different compared to the expression in their respective lymph nodes metastases. Expression of MAGE-A 3/4 in primary tumors showed significant positive correlation with primary tumor expression of NY-ESO-1 (P=0.021) but no significant correlation with the expression of MAGE-A 3/4 in lymph node metastases (P=0.056). Expression of NY-ESO-1 in primary tumors showed significant positive correlation with the expression of NY-ESO-1 in lymph node metastases (P=0.001) and significant negative correlation with patients’ age (P<0.001). Expression of MAGE-A 3/4 and NY-ESO-1 in primary tumors and lymph node metastases showed no significant correlation with prognostic parameters such as tumor grade and TNM stage (P>0.05). We have shown different levels of MAGE-A 3/4 and NY-ESO-1 expression in almost all specimens of primary tumor and lymph node metastases

  17. Esto/eso, que X/de que X en contraste. Del significado evidencial perceptivo al significado evidencial citativo

    OpenAIRE

    García Negroni, María Marta; Libenson, Manuel

    2014-01-01

    Este artículo busca poner de manifiesto, en primer lugar, el desplazamiento semántico-pragmático que, desde el significado propio de dos pronombres neutros con valor deíctico espacial, esto y eso, se produce hacia un significado evidencial perceptivo directo (esto/eso, que X) y desde allí hacia una lectura evidencial citativa (esto/eso de que X). Para dar cuenta de este movimiento desde la marcación de la evidencialidad directa a la de la evidencialidad indirecta, se realizará un análisis con...

  18. Préface

    Science.gov (United States)

    Chardonnet, Christian; Millot, Guy

    2006-10-01

    COLOQ, réunion nationale biennale initiée en 1988 par la communauté française des lasers, de l'optique non linéaire et de l'optique quantique atteint sa neuvième édition. Depuis sa création, les objectifs poursuivis sont les suivants : - réunir la communauté française des lasers, de l'optique non linéaire et de l'optique quantique, en dépassant les clivages fondamental/appliqué, recherche publique/industrielle, - faire le point sur les avancées récentes, - permettre aux jeunes chercheurs de se rencontrer, de s'exprimer et de s'aguerrir au plan national. Le but est que tout thésard du domaine de l'optique puisse participer à COLOQ une fois durant sa thèse, présenter son travail et de se confronter à la communauté de l'optique. COLOQ9 s'est tenu, pour sa 9e édition, sur le campus universitaire de Dijon, du 7 au 9 septembre 2005. Il a été une grande réussite : nombre de participants (255) et de présentations scientifiques record (148 affiches), forte représentation des industriels (15) et participation d'environ 200 lycéens aux conférences grand public. Le nombre plus élevé que prévu d'affiches a rendu un peu serrée leur présentation : une attention particulière sera portée à cet aspect lors des prochaines éditions. Ces journées ont été consacrées à des conférences invitées données par des scientifiques de haut niveau et à des présentations sous forme d'affiches. Une plage de temps importante a été réservée pour des discussions autour des affiches. À proximité immédiate de la salle de conférence, l'exposition de matériels spécialisés pour les lasers, l'optique et l'optoélectronique a été une occasion pour les jeunes participants de découvrir et contacter les industriels et les autres grands acteurs de l'optique. L'année 2005 ayant été l'année mondiale de la physique, COLOQ9 a retenu comme thème central ”1905-2005 : à propos d'Einstein". Plusieurs grandes conférences ont été dédiées à ce th

  19. Gaia-ESO Survey: The analysis of pre-main sequence stellar spectra

    CERN Document Server

    Lanzafame, A C; Damiani, F; Franciosini, E; Cottaar, M; Sousa, S G; Tabernero, H M; Klutsch, A; Spina, L; Biazzo, K; Prisinzano, L; Sacco, G G; Randich, S; Brugaletta, E; Mena, E Delgado; Adibekyan, V; Montes, D; Bonito, R; Gameiro, J F; Alcalá, J M; Hernández, J I González; Jeffries, R; Messina, S; Meyer, M; Gilmore, G; Asplund, M; Binney, J; Bonifacio, P; Drew, J E; Feltzing, S; Ferguson, A M N; Micela, G; Negueruela, I; Prusti, T; Rix, H-W; Vallenari, A; Alfaro, E J; Prieto, C Allende; Babusiaux, C; Bensby, T; Blomme, R; Bragaglia, A; Flaccomio, E; Francois, P; Hambly, N; Irwin, M; Koposov, S E; Korn, A J; Smiljanic, R; Van Eck, S; Walton, N; Bayo, A; Bergemann, M; Carraro, G; Costado, M T; Edvardsson, B; Heiter, U; Hill, V; Hourihane, A; Jackson, R J; Jofré, P; Lardo, C; Lewis, J; Lind, K; Magrini, L; Marconi, G; Martayan, C; Masseron, T; Monaco, L; Morbidelli, L; Sbordone, L; Worley, C C; Zaggia, S

    2015-01-01

    This paper describes the analysis of UVES and GIRAFFE spectra acquired by the Gaia-ESO Public Spectroscopic Survey in the fields of young clusters whose population includes pre-main sequence (PMS) stars. Both methods that have been extensively used in the past and new ones developed in the contest of the Gaia-ESO survey enterprise are available and used. The internal precision of these quantities is estimated by inter-comparing the results obtained by such different methods, while the accuracy is estimated by comparison with independent external data, like effective temperature and surface gravity derived from angular diameter measurements, on a sample of benchmarks stars. Specific strategies are implemented to deal with fast rotation, accretion signatures, chromospheric activity, and veiling. The analysis carried out on spectra acquired in young clusters' fields during the first 18 months of observations, up to June 2013, is presented in preparation of the first release of advanced data products. Stellar par...

  20. Observing facilities at the European Southern Observatory (ESO) in Chile for cometary observations

    Science.gov (United States)

    Schnur, G. F. O.; Kohoutek, L.; Rahe, J.

    1981-01-01

    The (ESO) is located on the mountain La Silla (geographical coordinates: 4h42m55s10 west, -29 deg 15' 25".8 south, 2400 m elevation. The size of the telescopes ranges from a 40 cm Astrograph to the 3.6 m Richey-Chretien telescope. Future telescopes are discussed: a 2.2 m RC-Telescope which will be identical with the German 2.2 m telescope on Calor Alto in SE-Spain, and a 3.5 m telescope, the New Technology Telescope. In addition to these telescopes, a great number of auxiliary instrumentation are operational. Because ESO has to serve all requests of the visiting astronomers these instruments are designed for very different applications. The telescopes and auxiliary instruments that are especially suited for cometary observations are discussed. The dicussion is divided into three parts: photography, photometry-polarimetry and spectroscopy.

  1. Tendencias nutricionales durante el horario de recreo en alumnos de ESO y Bachillerato

    OpenAIRE

    Granda Álvarez, Jorge

    2015-01-01

    En el presente trabajo se ha analizado la situación actual de los hábitos de alimentación en los snack de media mañana en la población ESO y Bachillerato y los motivos de esta situación. También se ha estudiado la labor de los centros educativos y de los profesores respecto a la educación alimenticia de los estudiantes. Se ha realizado un estudio en dos centros escolares de la Comunidad de Madrid a los alumnos de ESO y Bachillerato, el Colegio Castilla de Torrejón de la Calzada y el IES Manue...

  2. ESO 3060170: A massive fossil galaxy group with a heated gas core?

    DEFF Research Database (Denmark)

    Sun, M.; Forman, W.; Vikhlinin, A.

    2004-01-01

    We present a detailed study of the ESO 3060170 galaxy group, combining Chandra, XMM-Newton, and optical observations. The system is found to be a fossil galaxy group. The group X-ray emission is composed of a central, dense, cool core (10 kpc in radius) and an isothermal medium beyond the central...... 10 kpc. The region between 10 and 50 kpc (the cooling radius) has the same temperature as the gas from 50 to 400 kpc, although the gas cooling time between 10 and 50 kpc (2-6 Gyr) is shorter than the Hubble time. Thus, the ESO 3060170 group does not have a group-sized cooling core. We suggest...

  3. The Gaia-ESO Survey: the inner disk, intermediate-age open cluster Trumpler 23

    CERN Document Server

    Overbeek, J C; Donati, P; Smiljanic, R; Jacobson, H R; Hatzidimitriou, D; Held, E V; Magrini, L; Bragaglia, A; Randich, S; Vallenari, A; Cantat-Gaudin, T; Tautvaisiene, G; Jimenez-Esteban, F; Frasca, A; Geisler, D; Villanova, S; Tang, B; Munoz, C; Marconi, G; Carraro, G; Roman, I San; Drazdauskas, A; Zenoviene, R; Gilmore, G; Jeffries, R D; Flaccomio, E; Pancino, E; Bayo, A; Costado, M T; Damiani, F; Jofre, P; Monaco, L; Prisinzano, L; Sousa, S G; Zaggia, S

    2016-01-01

    Context: Trumpler 23 is a moderately populated, intermediate-age open cluster within the solar circle at a Rgc ~6 kpc. It is in a crowded field very close to the Galactic plane and the color-magnitude diagram shows significant field contamination and possible differential reddening; it is a relatively understudied cluster for these reasons, but its location makes it a key object for determining Galactic abundance distributions. Aims: New data from the Gaia-ESO Survey enable the first ever radial velocity and spectroscopic metallicity measurements for this cluster. We aim to use velocities to isolate cluster members, providing more leverage for determining cluster parameters. Methods: Gaia-ESO Survey data for 167 potential members have yielded radial velocity measurements, which were used to determine the systemic velocity of the cluster and membership of individual stars. Atmospheric parameters were also used as a check on membership when available. Literature photometry was used to re-determine cluster param...

  4. ESO 103-G35 - A new Seyfert galaxy and possible X-ray source

    Science.gov (United States)

    Phillips, M. M.; Feldman, F. R.; Marshall, F. E.; Wamsteker, W.

    1979-01-01

    By means of an objective prism plate, two emission-line galaxies have been identified within the 0.7-sq deg HEAO-A2 error box for the X-ray source H1834-653. Optical spectrophotometric observations are reported for both objects as well as the galaxy NGC 6684, which also lies near the position of H1834-653. These data show that one of the emission-line galaxies, ESO 103-G35, is a Seyfert galaxy with a high-excitation forbidden-line spectrum and weak broad emission wings at H-alpha. Further measurements of this galaxy reveal an infrared excess at wavelengths longer than 2.2 microns. The H-alpha luminosity of ESO 103-G35 is consistent with the X-ray luminosity estimated from the HEAO-A2 data, thus strengthening the likelihood of association of this galaxy with the X-ray emission.

  5. ESO 103-G35 - A new Seyfert galaxy and possible X-ray source

    Science.gov (United States)

    Phillips, M. M.; Feldman, F. R.; Marshall, F. E.; Wamsteker, W.

    1979-01-01

    By means of an objective prism plate, two emission-line galaxies have been identified within the 0.7-sq deg HEAO-A2 error box for the X-ray source H1834-653. Optical spectrophotometric observations are reported for both objects as well as the galaxy NGC 6684, which also lies near the position of H1834-653. These data show that one of the emission-line galaxies, ESO 103-G35, is a Seyfert galaxy with a high-excitation forbidden-line spectrum and weak broad emission wings at H-alpha. Further measurements of this galaxy reveal an infrared excess at wavelengths longer than 2.2 microns. The H-alpha luminosity of ESO 103-G35 is consistent with the X-ray luminosity estimated from the HEAO-A2 data, thus strengthening the likelihood of association of this galaxy with the X-ray emission.

  6. The ESO Distant Cluster Sample: galaxy evolution and environment out to z=1

    CERN Document Server

    Poggianti, Bianca M; Bamford, Steven; Barazza, Fabio; Best, Philip; Clowe, Douglas; Dalcanton, Julianne; De Lucia, Gabriella; Desai, Vandana; Finn, Rose; Halliday, Claire; Jablonka, Pascale; Johnson, Olivia; Milvang-Jensen, Bo; Moustakas, John; Noll, Stefan; Nowak, Nina; Pello, Roser; Poirier, Sebastien; Rudnick, Gregory; Saglia, Roberto; Sanchez-Blazquez, Patricia; Simard, Luc; Varela, Jesus; von der Linden, Anja; Whiley, Ian; White, Simon D M; Zaritsky, Dennis

    2009-01-01

    The ESO Distant Cluster Survey (EDisCS, P.I. Simon D.M. White, LP 166.A-0162) is an ESO large programme aimed at studying clusters and cluster galaxies at z=0.4-1. How different is the evolution of the star formation activity in clusters, in groups and in the field? Does it depend on cluster mass and/or the local galaxy density? How relevant are starburst and post-starburst galaxies in the different environments? Is there an evolution in the galaxies' structures, and if so, is this related to the changes in their star formation activity? These are some of the main questions that have been investigated using the EDisCS dataset.

  7. Early-type massive stars in Carina Nebula within the Gaia-ESO Survey.

    Science.gov (United States)

    Berlanas, S. R.; Herrero, A.; Martins, F.; Simón-Díaz, S.; Mahy, L.; Blomme, R.; GES WG-13

    2017-03-01

    The Gaia-ESO Survey (GES) is obtaining high quality spectra of ˜ 10^5 stars in our Galaxy, providing an homogeneous and unique overview of all the main components of the Milky Way, its formation history and the evolution of young, mature and ancient Galactic populations. Our group is in charge of the early-type massive stars that define the youngest population in the survey. In this contribution, we present the results of the quantitative spectroscopic analysis of O-type stars in the Carina Nebula within the Gaia-ESO Survey. For this aim, we have used FASTWIND and CMFGEN stellar atmosphere codes, providing stellar parameters for the current sample (GES data release iDR4).

  8. ESO 3060170: A massive fossil galaxy group with a heated gas core?

    DEFF Research Database (Denmark)

    Sun, M.; Forman, W.; Vikhlinin, A.

    2004-01-01

    .85). This is direct evidence of the importance of nongravitational processes in group centers. We derive the mass profiles within 1/3r(vir) and find that the ESO 3060170 group is the most massive fossil group known [(1-2)x10(14) M-circle dot]. The M/L ratio of the system, similar to150 at 0.3r(vir), is normal.......We present a detailed study of the ESO 3060170 galaxy group, combining Chandra, XMM-Newton, and optical observations. The system is found to be a fossil galaxy group. The group X-ray emission is composed of a central, dense, cool core (10 kpc in radius) and an isothermal medium beyond the central...

  9. Expression and clinical significance of NY-ESO-1 protein in human laryngeal squamous carcinoma%NY-ESO-1蛋白在喉鳞状细胞癌中表达的意义

    Institute of Scientific and Technical Information of China (English)

    田俊; 王斌全; 李建民; 皇甫辉; 温树信; 张艳廷

    2010-01-01

    目的 检测NY-ESO-1蛋白在喉鳞癌中的表达情况,探讨其作为喉癌免疫治疗靶标的实验依据及其与喉癌生物学行为的关系.方法 免疫组织化学PV-9000两步法检测69例喉鳞癌患者原发灶及其常规病理报告为阳性的121个颈淋巴结中NY-ESO-1的表达,同时采用Western blotting方法检测其在喉鳞癌标本的癌中心区、癌周0.5、1.0 cm及9例全喉切除术患者的喉正常黏膜组织(对照)中的表达.结果 69例喉鳞癌组织中,NY-ESO-1蛋白表达阳性率为43.48%(30/69),在癌中心区、癌周0.5、1.0cm中的表达逐渐下降(P<0.05),NY-ESO-1在对照组喉正常黏膜组织中无表达.NY-ESO-1蛋白在不同T分级、病理分级和不同颈淋巴结转移喉癌中的表达率差异无统计学意义(P>0.05),颈转移淋巴结中NY-ESO-1的表达下调.结论 NY-ESO-1在喉鳞癌患者中特异性高表达,可能以某种方式参与了喉癌的发生、发展,是否能将其作为喉癌免疫治疗靶标有待深入研究.%Objective To detect the expression of Cancer-Testis antigen NY-ESO-1 in human laryngeal squamous carcinoma (LSC) and to explore its significance in immunotherapeutic application. Methods The expressions of NY-ESO-1 protein in the LSC and in the pathologically positive lymph nodes were detected by PV-9000 Immunohistochemistry. Western blotting was also employed to measure the expressions of NY-ESO-1 in the tumor core region(TC), the tissues at the sites of 0.5cm, 1.0cm away from LSC periphery and the distant normal larynx tissues. Results NY-ESO-1 protein expression was positive in 30 out of 69 (43.48 %) cases of LSC. The expression level of NY-ESO-1 protein were found to significantly decrease by tums in TC and corresponding adjacent tissues (P <0.01). None of the nine normal larynx tissues expressed NY-ESO-1 protein.It did not display an obvious correlation between the expression of NY-ESO-1 with T staging, pathological grading and lymph node metastasis (P

  10. Prólogo

    OpenAIRE

    Rodríguez Mejía, Marcela

    2014-01-01

    Presentar esta obra me resulta tremendamente grato. Por un lado, porque el tema de las medidas cautelares en el arbitraje es una de las líneas de investigación que me han preocupado en estos últimos años, tanto desde un punto de vista doctrinal como en la práctica arbitral; y, por otro, porque la autora de esta obra guarda conmigo una estrecha relación personal, fruto de los cuatro años que hemos colaborado y trabajado conjuntamente en la Universitat de València. Para comenzar por el objeto d...

  11. Présentation

    Directory of Open Access Journals (Sweden)

    Stéphane Haber

    2010-08-01

    Full Text Available Les articles réunis dans ce dossier de la revue Astérion portent sur la première génération de la Théorie critique (dont Max Horkheimer, Walter Benjamin, Theodor W. Adorno, Herbert Marcuse et Erich Fromm constituent sans doute les figures principales. Ils se concentrent plus précisément sur les contributions philosophiques qui marquèrent la période ouverte par l’accession de Horkheimer à la direction de l’Institut de recherches sociales (1931 et close par la publication en 1944 de Dialektik...

  12. VizieR Online Data Catalog: R magnitudes in four ESO fields (Infante+, 1996)

    Science.gov (United States)

    Infante, L.; Slezak, E.; Quintana, H.

    1996-04-01

    The tables present a R-band CCD photometric sequence of stars for calibrating ESO/SERC(R) survey plates in the region of the Shapley supercluster of galaxies. The observations were carried out on 1993 Ferbruary 17 to 22 at the 0.6m telescope of the University of Toronto at Las Campanas Observatory in Chile, using a 513x516pix CCD with a resolution of 0.46''. (16 data files).

  13. Radio Detection of SN 2016bas in ESO 163-G011

    Science.gov (United States)

    Ryder, S. D.; Kool, E. C.; Stockdale, C. J.; Kotak, R.

    2016-03-01

    The nearby Type IIb supernova SN 2016bas (ATel #8814) in ESO 163-G011 has been observed with the Australia Telescope Compact Array (ATCA) on 2016 March 17.4 UT. We detected a radio source at a position consistent with that measured optically, and fluxes of 0.56+/-0.03 mJy and 0.21+/-0.02 mJy at 9.0 and 5.5 GHz, respectively.

  14. Immunohistochemical assessment of NY-ESO-1 expression in esophageal adenocarcinoma resection specimens.

    Science.gov (United States)

    Hayes, Stephen J; Hng, Keng Ngee; Clark, Peter; Thistlethwaite, Fiona; Hawkins, Robert E; Ang, Yeng

    2014-04-14

    To assess NY-ESO-1 expression in a cohort of esophageal adenocarcinomas. A retrospective search of our tissue archive for esophageal resection specimens containing esophageal adenocarcinoma was performed, for cases which had previously been reported for diagnostic purposes, using the systematised nomenclature of human and veterinary medicine coding system. Original haematoxylin and eosin stained sections were reviewed, using light microscopy, to confirm classification and tumour differentiation. A total of 27 adenocarcinoma resection specimens were then assessed using immunohistochemistry for NY-ESO-1 expression: 4 well differentiated, 14 moderately differentiated, 4 moderate-poorly differentiated, and 5 poorly differentiated. Four out of a total of 27 cases of esophageal adenocarcinoma examined (15%) displayed diffuse cytoplasmic and nuclear expression for NY-ESO-1. They displayed a heterogeneous and mosaic-type pattern of diffuse staining. Diffuse cytoplasmic staining was not identified in any of these structures: stroma, normal squamous epithelium, normal submucosal gland and duct, Barrett's esophagus (goblet cell), Barrett's esophagus (non-goblet cell) and high grade glandular dysplasia. All adenocarcinomas showed an unexpected dot-type pattern of staining at nuclear, paranuclear and cytoplasmic locations. Similar dot-type staining, with varying frequency and size of dots, was observed on examination of Barrett's metaplasia, esophageal submucosal gland acini and the large bowel negative control, predominantly at the crypt base. Furthermore, a prominent pattern of apical (luminal) cytoplasmic dot-type staining was observed in some cases of Barrett's metaplasia and also adenocarcinoma. A further morphological finding of interest was noted on examination of haematoxylin and eosin stained sections, as aggregates of lymphocytes were consistently noted to surround submucosal glands. We have demonstrated for the first time NY-ESO-1 expression by esophageal

  15. Assembly and test results of the AOF laser guide star units at ESO

    Science.gov (United States)

    Hackenberg, W.; Bonaccini Calia, D.; Buzzoni, B.; Comin, M.; Dupuy, C.; Gago, F.; Guidolin, I. M.; Guzman, R.; Holzloehner, R.; Kern, L.; Kirchbauer, J.-.; Lewis, S.; Lizon, J.-.; McLay, S.; Pfrommer, T.; Quattri, M.; Quentin, J.; Ridings, R.

    2014-08-01

    The Four Laser Guide Star Facility (4LGSF) is part of the ESO Adaptive Optics Facility, in which one of the VLT telescopes, UT4, is transformed in an adaptive telescope-equipped with a deformable secondary mirror, two adaptive optics systems at the Nasmyth focii and four sodium laser guide star modular units. In this paper we present the design, the assembly and validation test performed so far in Europe on the first laser guide star unit.

  16. Very Large Telescope Adaptive Optics Community Days Report on the ESO Workshop

    Science.gov (United States)

    Leibundgut, B.; Kasper, M.; Kuntschner, H.

    2016-12-01

    The future of adaptive optics (AO) instruments at the VLT was discussed during a two-day workshop. Three major directions emerged from these discussions: adaptive optics in the optical; multi-object adaptive optics (MOAO); and extreme adaptive optics (XAO). The science cases for these three options were presented and the discussions are summarised. ESO is now planning to provide detailed science cases for an optical AO system and to prepare upgrade plans for XAO and MOAO.

  17. A novel murine T-cell receptor targeting NY-ESO-1.

    Science.gov (United States)

    Rosati, Shannon F; Parkhurst, Maria R; Hong, Young; Zheng, Zhili; Feldman, Steven A; Rao, Mahadev; Abate-Daga, Daniel; Beard, Rachel E; Xu, Hui; Black, Mary A; Robbins, Paul F; Schrump, David A; Rosenberg, Steven A; Morgan, Richard A

    2014-04-01

    Cancer testis antigens, such as NY-ESO-1, are expressed in a variety of prevalent tumors and represent potential targets for T-cell receptor (TCR) gene therapy. DNA encoding a murine anti-NY-ESO-1 TCR gene (mTCR) was isolated from immunized HLA-A*0201 transgenic mice and inserted into a γ-retroviral vector. Two mTCR vectors were produced and used to transduce human PBL. Transduced cells were cocultured with tumor target cell lines and T2 cells pulsed with the NY-ESO-1 peptide, and assayed for cytokine release and cell lysis activity. The most active TCR construct was selected for production of a master cell bank for clinical use. mTCR-transduced PBL maintained TCR expression in short-term and long-term culture, ranging from 50% to 90% efficiency 7-11 days after stimulation and 46%-82% 10-20 days after restimulation. High levels of interferon-γ secretion were observed (1000-12000 pg/mL), in tumor coculture assays and recognition of peptide-pulsed cells was observed at 0.1 ng/mL, suggesting that the new mTCR had high avidity for antigen recognition. mTCR-transduced T cells also specifically lysed human tumor targets. In all assays, the mTCR was equivalent or better than the comparable human TCR. As the functional activity of TCR-transduced cells may be affected by the formation of mixed dimers, mTCRs, which are less likely to form mixed dimers with endogenous hTCRs, may be more effective in vivo. This new mTCR targeted to NY-ESO-1 represents a novel potential therapeutic option for adoptive cell-transfer therapy for a variety of malignancies.

  18. ASASSN-16mv: Discovery of A Probable Supernova in ESO 563- G 035

    Science.gov (United States)

    Nicholls, B.; Shields, J.; Stanek, K. Z.; Kochanek, C. S.; Brown, J. S.; Holoien, T. W.-S.; Shappee, B. J.; Prieto, J. L.; Bersier, D.; Dong, Subo; Bose, S.; Chen, Ping; Brimacombe, J.; Stone, G.; Post, R. S.; Masi, G.; Koff, R. A.

    2016-11-01

    During the ongoing All Sky Automated Survey for SuperNovae (ASAS-SN or "Assassin"), using data from the quadruple 14-cm "Cassius" telescope in Cerro Tololo, Chile, we discovered a new transient source, most likely a supernova, in the galaxy ESO 563- G 035. ASASSN-16mv was discovered in images obtained on UT 2016-11-04.31 at V 16.8 mag. We also detect the object in images obtained on several previous epochs.

  19. Study on Degradation Performance of Star-Shaped Polymer of ESO and Lactide%ESO-丙交酯星形聚合物的降解性能研究

    Institute of Scientific and Technical Information of China (English)

    张贝; 付春华; 王远亮

    2011-01-01

    环氧大豆油-丙交酯(ESO-丙交酯)星形聚合物是一种新型支化高分子材料,它的应用与其降解性能有着重要关系.影响降解的因素很多,本文选用磷酸缓冲液进行了实时体外降解实验,将聚(D,L-乳酸)( PDLLA)与其支化后得到的ESO-丙交酯星形聚合物的降解实验进行对比,研究发现对于表面形态、pH、分子量及失重率,支化ESO-丙交酯星形聚合物的变化程度慢于PDLLA,这对于ESO-丙交酯进一步应用具有非常重要的指导意义.%Star-Shaped Polymer of epoxidized soybean oil (ESO) and Lactide is a new material. Its degradation function has an importance to its applications. There are many factors affecting its degradation. This paper is mainly aimed at investigation in which the surface morphology, pH, molecular weight and weight loss rate, branching ESO lactide star polymers the degree of change were studied. It was found through the experiments that, the changing rates of the branching ESO-lactide star polymers were slower than the degree of PDLLA change compared to the surface morphology, pH, molecular weight and weight loss rate. This has a guiding significance to the further application of ESO-lactide.

  20. NY-ESO-1 Protein Cancer Vaccine With Poly-ICLC and OK-432: Rapid and Strong Induction of NY-ESO-1-specific Immune Responses by Poly-ICLC.

    Science.gov (United States)

    Takeoka, Tomohira; Nagase, Hirotsugu; Kurose, Koji; Ohue, Yoshihiro; Yamasaki, Makoto; Takiguchi, Shuji; Sato, Eiichi; Isobe, Midori; Kanazawa, Takayuki; Matsumoto, Mitsunobu; Iwahori, Kota; Kawashima, Atsunari; Morimoto-Okazawa, Akiko; Nishikawa, Hiroyoshi; Oka, Mikio; Pan, Linda; Venhaus, Ralph; Nakayama, Eiichi; Mori, Masaki; Doki, Yuichiro; Wada, Hisashi

    2017-03-23

    We conducted a clinical trial of a cancer vaccine using NY-ESO-1 protein with polyinosinic-polycytidylic acid-poly-L-lysine carboxymethylcellulose (poly-ICLC) and/or OK-432 against solid tumors. A total of 15 patients were sequentially enrolled in 4 cohorts. Patients in cohort 1 received NY-ESO-1 protein; cohort 2a received NY-ESO-1 protein+OK-432; cohort 2b received NY-ESO-1 protein+poly-ICLC; cohort 3 received NY-ESO-1 protein+OK-432+poly-ICLC with Montanide ISA-51. The endpoints of this trial were safety, NY-ESO-1 immune responses, and clinical response. Vaccine-related adverse events observed were fever and injection-site reaction (grade 1). Two patients showed stable disease after vaccination. NY-ESO-1 antibodies were observed in 4 patients at the baseline (sero-positive) and augmented in all patients after vaccination. Eleven patients showed a conversion of negative antibody responses at baseline to positive after vaccination (seroconversion). The seroconversions were observed in all 11 sero-negative patients by the fourth immunization; in particular, it was observed by the second immunization in patients with poly-ICLC, and these induced antibody responses were stronger than those in patients immunized without poly-ICLC. The number of NY-ESO-1-specific interferon (IFN)γ-producing T cells was increased in patients immunized with poly-ICLC and/or OK-432, and furthermore, the increase of IFNγ-producing CD8 T cells in patients immunized with poly-ICLC was significantly higher than that in patients without poly-ICLC. Nonspecific activations of T-cell or antigen presenting cells were not observed. Our present study showed that poly-ICLC is a promising adjuvant for cancer vaccines.

  1. Molecular cloning, prokaryotic expression and purification of human CT antigen NY-ESO-1%CT抗原NY-ESO-1基因克隆、表达及纯化

    Institute of Scientific and Technical Information of China (English)

    江华; 郑玉玲; 姜永强

    2007-01-01

    目的:利用大肠杆菌表达人CT抗原NY-ESO-1,对表达产物进行Western印迹鉴定和纯化,为今后利用其进行肿瘤疫苗的研究奠定基础.方法:通过全基因拼接获得NY-ESO-1基因,构建重组表达载体NY-ESO-1-pET28a(+),在大肠杆菌BL21(DE3)中利用IPTG诱导获得表达,利用单克隆抗体进行Western印迹鉴定,通过Ni柱亲和纯化获得纯化蛋白.结果与结论:拼接的NY-ESO-1全基因经测序证明与GenBank中人的NY-ESO-l全基因完全相符;构建的原核表达载体NY-ESO-1-pET28a(+)可稳定地可溶性表达NY-ESO-1蛋白;经Ni柱亲和纯化获得较好的纯化结果;利用鼠抗人单克隆抗体对表达的蛋白进行验证,结果显示阳性.本研究成功利用原核表达系统实现了对CT抗原NY-ESO-1的可溶性表达.

  2. Robust sliding mode control with ESO for dual-control missile

    Institute of Scientific and Technical Information of China (English)

    Wei Shang; Shengjing Tang; Jie Guo; Yueyue Ma; Yuhang Yun

    2016-01-01

    This paper proposes a novel composite dual-control by combing the integral sliding mode control (ISMC) method based on the finite time convergence theory with extended state observer (ESO) for a tracking problem of a missile with tail fins and reaction-jet control system (RCS). First, the ISMC method based on finite time convergence is utilized to design the control law of tail fins and the pulse control of RCS for the dual-control system, ensuring the system with rapid response and high accuracy of tracking. Then, ESO is employed for the estimation of aerodynamic disturbances influenced by the airflow of thruster jets. With the characteristic of high accuracy estimation of ESO, the chattering free tracking performance of the attack angle command and the robustness of the control law are achieved. Meanwhile, the stability of the dual-control system is analyzed based on finite time convergence stability theorem and Lyapunov’s theorem. Final y, numerical sim-ulations demonstrate the effectiveness of the proposed design.

  3. TCS and peripheral robotization and upgrade on the ESO 1-meter telescope at La Silla Observatory

    Science.gov (United States)

    Ropert, S.; Suc, V.; Jordán, A.; Tala, M.; Liedtke, P.; Royo, S.

    2016-07-01

    In this work we describe the robotization and upgrade of the ESO 1m telescope located at La Silla Observatory. The ESO 1m telescope was the first telescope installed in La Silla, in 1966. It now hosts as a main instrument the FIber Dual EchellE Optical Spectrograph (FIDEOS), a high resolution spectrograph designed for precise Radial Velocity (RV) measurements on bright stars. In order to meet this project's requirements, the Telescope Control System (TCS) and some of its mechanical peripherals needed to be upgraded. The TCS was also upgraded into a modern and robust software running on a group of single board computers interacting together as a network with the CoolObs TCS developed by ObsTech. One of the particularities of the CoolObs TCS is that it allows to fuse the input signals of 2 encoders per axis in order to achieve high precision and resolution of the tracking with moderate cost encoders. One encoder is installed on axis at the telescope and the other on axis at the motor. The TCS was also integrated with the FIDEOS instrument system so that all the system can be controlled through the same remote user interface. Our modern TCS unit allows the user to run observations remotely through a secured internet web interface, minimizing the need of an on-site observer and opening a new age in robotic astronomy for the ESO 1m telescope.

  4. Integration of the instrument control electronics for the ESPRESSO spectrograph at ESO-VLT

    Science.gov (United States)

    Baldini, V.; Calderone, G.; Cirami, R.; Coretti, I.; Cristiani, S.; Di Marcantonio, P.; Mégevand, D.; Riva, M.; Santin, P.

    2016-07-01

    ESPRESSO, the Echelle SPectrograph for Rocky Exoplanet and Stable Spectroscopic Observations of the ESO - Very Large Telescope site, is now in its integration phase. The large number of functions of this complex instrument are fully controlled by a Beckhoff PLC based control electronics architecture. Four small and one large cabinets host the main electronic parts to control all the sensors, motorized stages and other analogue and digital functions of ESPRESSO. The Instrument Control Electronics (ICE) is built following the latest ESO standards and requirements. Two main PLC CPUs are used and are programmed through the TwinCAT Beckhoff dedicated software. The assembly, integration and verification phase of ESPRESSO, due to its distributed nature and different geographical locations of the consortium partners, is quite challenging. After the preliminary assembling and test of the electronic components at the Astronomical Observatory of Trieste and the test of some electronics and software parts at ESO (Garching), the complete system for the control of the four Front End Unit (FEU) arms of ESPRESSO has been fully assembled and tested in Merate (Italy) at the beginning of 2016. After these first tests, the system will be located at the Geneva Observatory (Switzerland) until the Preliminary Acceptance Europe (PAE) and finally shipped to Chile for the commissioning. This paper describes the integration strategy of the ICE workpackage of ESPRESSO, the hardware and software tests that have been performed, with an overall view of the experience gained during these project's phases.

  5. The AMBRE Project: Stellar Parameterisation of the ESO:UVES archived spectra

    CERN Document Server

    Worley, C C; Recio-Blanco, A; Hill, V; Bijaoui, A

    2016-01-01

    The AMBRE Project is a collaboration between the European Southern Observatory (ESO) and the Observatoire de la Cote d'Azur (OCA) that has been established in order to carry out the determination of stellar atmospheric parameters for the archived spectra of four ESO spectrographs. The analysis of the UVES archived spectra for their stellar parameters has been completed in the third phase of the AMBRE Project. From the complete ESO:UVES archive dataset that was received covering the period 2000 to 2010, 51921 spectra for the six standard setups were analysed. The AMBRE analysis pipeline uses the stellar parameterisation algorithm MATISSE to obtain the stellar atmospheric parameters. The synthetic grid is currently constrained to FGKM stars only. Stellar atmospheric parameters are reported for 12,403 of the 51,921 UVES archived spectra analysed in AMBRE:UVES. This equates to ~23.9% of the sample and ~3,708 stars. Effective temperature, surface gravity, metallicity and alpha element to iron ratio abundances are ...

  6. ESO Imaging Survey. Hubble Deep Field South Optical-Infrared Observations, Data Reduction and Photometry

    CERN Document Server

    Da Costa, L N; Rengelink, R B; Zaggia, S R; Benoist, C; Erben, T; Wicenec, A; Scodeggio, M; Olsen, L F; Guarnieri, M D; Deul, E; D'Odorico, S; Hook, R N; Moorwood, A F M; Slijkhuis, R

    1998-01-01

    This paper presents ground-based data obtained from deep optical and infrared observations of the HST Hubble Deep Field South (HDF-S) field carried out at the ESO 3.5 New Technology Telescope (NTT). These data were taken as part of the ESO Imaging Survey (EIS) program, a public survey coordinated by ESO and member states, in preparation for the first year of operation of the VLT. Deep CCD images are available for five optical passbands, reaching 2 sigma limiting magnitudes of U_AB~27.0, B_AB~26.5, V_AB~26, R_AB~26, I_AB~25, covering a region of ~25 square arcmin, which includes the HST WPFC2 field. The infrared observations cover a total area of ~42 square arcmin and include both the HST WFPC2 and STIS fields. The observations of the WFPC2 region were conducted in JHKs passbands, reaching J_AB~25, and H_AB and K_AB~24.0. Due to time constraints, the adjacent field, covering the STIS field, has been observed only in R, I and JHKs, while no observations were conducted covering the NIC3 field. This paper describ...

  7. TWO-DIMENSIONAL KINEMATICS OF THE EDGE-ON SPIRAL GALAXY ESO 379-006

    Energy Technology Data Exchange (ETDEWEB)

    Rosado, M.; Gabbasov, R. F.; Repetto, P.; Martos, M. [Instituto de Astronomia, Universidad Nacional Autonoma de Mexico, Apartado Postal 70-264, CP 04510 Mexico, D. F. (Mexico); Fuentes-Carrera, I. [Escuela Superior de Fisica y Matematicas, Instituto Politecnico Nacional, U. P. Adolfo Lopez Mateos, Zacatenco, 07730 Mexico, D. F. (Mexico); Amram, P.; Hernandez, O. [Laboratoire d' Astrophysique de Marseille, Aix-Marseille University (France); CNRS, 38 rue Frederic Joliot-Curie, 13338 Marseille Cedex 13 (France)

    2013-05-15

    We present a kinematical study of the nearly edge-on galaxy ESO 379-006 that shows the existence of extraplanar ionized gas. With Fabry-Perot spectroscopy at H{alpha}, we study the kinematics of ESO 379-006 using velocity maps and position-velocity diagrams parallel to the major and to the minor axis of the galaxy. We build the rotation curve of the disk and discuss the role of projection effects due to the fact of viewing this galaxy nearly edge-on. The twisting of the isovelocities in the radial velocity field of the disk of ESO 379-006 as well as the kinematical asymmetries found in some position-velocity diagrams parallel to the minor axis of the galaxy suggest the existence of deviations to circular motions in the disk that can be modeled and explained with the inclusion of a radial inflow probably generated by a bar or by spiral arms. We succeeded in detecting extraplanar diffuse ionized gas in this galaxy. At the same time, from the analysis of position-velocity diagrams, we found some evidence that the extraplanar gas could lag in rotation velocity with respect to the midplane rotation.

  8. 2D kinematics of the edge-on spiral galaxy ESO 379-G006

    CERN Document Server

    Rosado, M; Repetto, P; Fuentes-Carrera, I; Amram, P; Martos, M; Hernandez, O

    2013-01-01

    We present a kinematical study of the nearly edge-on galaxy ESO 379-G006 that shows the existence of extraplanar ionized gas. With Fabry-Perot spectroscopy at H-alpha, we study the kinematics of ESO 379-G006 using velocity maps and position-velocity diagrams parallel to the major and to the minor axis of the galaxy. We build the rotation curve of the disk and discuss the role of projection effects due to the fact of viewing this galaxy nearly edge-on. The twisting of the isovelocities in the radial velocity field of the disk of ESO 379-G006 as well as the kinematic asymmetries found in some position-velocity diagrams parallel to the minor axis of the galaxy suggest the existence of deviations to circular motions in the disk that can be modeled and explained with the inclusion of a radial inflow probably generated by a bar or by spiral arms. We succeeded in detecting extraplanar Diffuse Ionized Gas in this galaxy. At the same time, from the analysis of position-velocity diagrams, we found some evidence that th...

  9. Resiquimod as an Immunologic Adjuvant for NY-ESO-1 Protein Vaccination in Patients with High Risk Melanoma

    Science.gov (United States)

    Gnjatic, Sacha; Cruz, Crystal M.; Vengco, Isabelita; Hasan, Farah; Spadaccia, Meredith; Darvishian, Farbod; Chiriboga, Luis; Holman, Rose Marie; Escalon, Juliet; Muren, Caroline; Escano, Crystal; Yepes, Ethel; Sharpe, Dunbar; Vasilakos, John P.; Rolnitzsky, Linda; Goldberg, Judith; Mandeli, John; Adams, Sylvia; Jungbluth, Achim; Pan, Linda; Venhaus, Ralph; Ott, Patrick A.; Bhardwaj, Nina

    2015-01-01

    The TLR7/8 agonist, Resiquimod has been used as an immune adjuvant in cancer vaccines. We evaluated the safety and immunogenicity of the cancer testis antigen NY-ESO-1 given in combination with Montanide with or without Resiquimod in high-risk melanoma patients. In Part I of the study, patients received 100ug full length NY-ESO-1 protein emulsified in 1.25mL Montanide (day 1) followed by topical application of 1000mg of 0.2% Resiquimod gel on days 1 and 3 (Cohort 1) versus days 1, 3, and 5 (Cohort 2) of a 21 day cycle. In Part II, patients were randomized to receive 100ug NY-ESO-1 protein plus Montanide (day 1) followed by topical application of placebo gel (Arm-A; N=8) or 1000mg of 0.2% Resiquimod gel (Arm-B; N=12) using the dosing regimen established in Part I. The vaccine regimens were generally well-tolerated. NY-ESO-1-specific humoral responses were induced or boosted in all patients, many of whom had high titer antibodies. In Part II, 16 of 20 patients in both arms had NY-ESO-1-specific CD4+ T-cell responses. CD8+ T-cell responses were only seen in 3 of 12 patients in Arm B. Patients with TLR7 SNP rs179008 had a greater likelihood of developing NY-ESO-1-specific CD8+ responses. In conclusion, NY-ESO-1 protein in combination with Montanide with or without topical Resiquimod is safe and induces both antibody and CD4+ T-cell responses in the majority of patients; the small proportion of CD8+ T-cell responses suggests that the addition of topical Resiquimod to Montanide is not sufficient to induce consistent NY-ESO-1-specific CD8+ T-cell responses. PMID:25633712

  10. The OmegaCAM 16K x 16K CCD detector system for the ESO VLT Survey Telescope (VST)

    NARCIS (Netherlands)

    Iwert, Olaf; Baade, D.; Balestra, A.; Baruffolo, A.; Bortolussi, A.; Christen, F.; Cumani, C.; Deiries, S.; Downing, M.; Geimer, C.; Hess, G.; Hess, J.; Kuijken, K.; Lizon, J.; Muschielok, B.; Nicklas, H.; Reiss, R.; Reyes, J.; Silber, A.; Thillerup, J.; Valentijn, E.; Dorn, David A.; Holland, Andrew D.

    2006-01-01

    A 16K x 16K, 1 degree x 1 degree field, detector system was developed by ESO for the OmegaCAM instrument for use on the purpose built ESO VLT Survey Telescope (VST). The focal plane consists of an 8 x 4 mosaic of 2K x 4K 15um pixel e2v CCDs and four 2K x 4K CCDs on the periphery for the opto-mechani

  11. NY-ESO-1在喉鳞状细胞癌中的表达及意义

    Institute of Scientific and Technical Information of China (English)

    周慧; 凌红阳; 吴文璎; 郑玉双

    2015-01-01

    目的 探讨喉鳞状细胞癌组织中NY-ESO-1蛋白表达及其临床意义.方法 免疫组化方法检测88例喉鳞状细胞癌组织(A组)和10例声带息肉组织(B组)NY-ESO-1蛋白的表达.A组再分为四个亚组,临床分期Ⅰ、Ⅱ期38例(A1组),临床分期Ⅲ、Ⅳ期50例(A2组);病理类型高、中分化60例(A3组),低分化28例(A4组).结果 A组NY-ESO-1蛋白表达水平高于B组(4598±2302 vs.0)(P<0.01).A1组NY-ESO-1表达水平高于A2组(8052±3810 vs.162±107)(P<0.05).A3组NY-ESO-1表达水平高于A4组(5090±1893 vs.211±201) (P<0.05).结论 NY-ESO-1有可能作为喉鳞癌早期诊断的新指标;NY-ESO-1表达阳性的高、中分化喉鳞癌患者可能可以选择NY-ESO-1疫苗作为辅助治疗.

  12. ESO 243-49 HLX-1: scaling of X-ray spectral properties and black hole mass determination

    Science.gov (United States)

    Titarchuk, Lev; Seifina, Elena

    2016-11-01

    We report the results of Swift/XRT observations (2008-2015) of a hyper-luminous X-ray source, ESO 243-49 HLX-1. We demonstrate a strong observational evidence that ESO 243-49 HLX-1 undergoes spectral transitions from the low/hard state to the high/soft state during these observations. The spectra of ESO 243-49 HLX-1 are well fitted by the so-called bulk motion Comptonization model for all spectral states. We have established the photon index (Γ) saturation level, Γsat = 3.0 ± 0.1, in the Γ versus mass accretion rate (Ṁ) correlation. This Γ-Ṁ correlation allows us to estimate black hole (BH) mass in ESO 243-49 HLX-1 to be MBH 7 × 104 M⊙ assuming the distance to ESO 243-49 of 95 Mpc. For the BH mass estimate we use the scaling method taking Galactic BHs XTE J1550-564, H 1743-322 and 4U 1630-472, and an extragalactic BH source, M101 ULX-1 as reference sources. The Γ versus Ṁ correlation revealed in ESO 243-49 HLX-1 is similar to those in a number of Galactic and extragalactic BHs and it clearly shows the correlation along with the strong Γ saturation at ≈3. This is a robust observational evidence for the presence of a BH in ESO 243-49 HLX-1. We also find that the seed (disk) photon temperatures are quite low, of order of 50-140 eV which are consistent with high BH mass in ESO 243-49 HLX-1.

  13. MOSE: A Demonstrator for an Automatic Operational System for the Optical Turbulence Forecast for ESO Sites

    Science.gov (United States)

    Masciadri, Elena; Lascaux, F.; Turchi, A.; Fini, L.

    2017-09-01

    "Most of the observations performed with new-generation ground-based telescopes are employing the Service Mode. To optimize the flexible-scheduling of scientific programs and instruments, the optical turbulence (OT) forecast is a must, particularly when observations are supported by adaptive optics (AO) and Interferometry. Reliable OT forecast are crucial to optimize the usage of AO and interferometric facilities which is not possible when using only optical measurements. Numerical techniques are the best placed to achieve such a goal. The MOSE project (MOdeling ESO Sites), co-funded by ESO, aimed at proving the feasibility of the forecast of (1) all the classical atmospheric parameters (such as temperature, wind speed and direction, relative humidity) and (2) the optical turbulence i.e. the CN 2 profiles and all the main integrated astro-climatic parameters derived from the CN 2 (the seeing, the isoplanatic angle, the wavefront coherence time) above the two ESO sites of Cerro Paranal and Cerro Armazones. The proposed technique is based on the use of a non-hydrostatic atmospheric meso-scale model and a dedicated code for the optical turbulence. The final goal of the project aimed at implementing an automatic system for the operational forecasts of the aforementioned parameters to support the astronomical observations above the two sites. MOSE Phase A and B have been completed and a set of dedicated papers have been published on the topic. Model performances have been extensively quantified with several dedicated figures of merit and we proved that our tool is able to provide reliable forecasts of optical turbulence and atmospheric parameters with very satisfactory score of success. This should guarantee us to make a step ahead in the framework of the Service Mode of new generation telescopes. A conceptual design as well as an operational plan of the automatic system has been submitted to ESO as integral part of the feasibility study. We completed a negotiation with

  14. Immune escape from NY-ESO-1-specific T-cell therapy via loss of heterozygosity in the MHC.

    Science.gov (United States)

    Klippel, Z K; Chou, J; Towlerton, A M; Voong, L N; Robbins, P; Bensinger, W I; Warren, E H

    2014-03-01

    Adoptive immunotherapy of tumors with T cells specific for the cancer-testis antigen NY-ESO-1 has shown great promise in preclinical models and in early stage clinical trials. Tumor persistence or recurrence after NY-ESO-1-specific therapy occurs, however, and the mechanisms of recurrence remain poorly defined. In a murine xenograft model of NY-ESO-1(+) multiple myeloma, we observed tumor recurrence after adoptive transfer of CD8(+) T cells genetically redirected to the prototypic NY-ESO-1157-165 peptide presented by HLA-A*02:01. Analysis of the myeloma cells that had escaped from T-cell control revealed intact expression of NY-ESO-1 and B2M, but selective, complete loss of HLA-A*02:01 expression from the cell surface. Loss of heterozygosity (LOH) in the major histocompatibility complex (MHC) involving the HLA-A locus was identified in the tumor cells, and further analysis revealed selective loss of the allele encoding HLA-A*02:01. Although LOH involving the MHC has not been described in myeloma patients with persistent or recurrent disease after immune therapies such as allogeneic hematopoietic cell transplantation (HCT), it has been described in patients with acute myelogenous leukemia who relapsed after allogeneic HCT. These results suggest that MHC loss should be evaluated in patients with myeloma and other cancers who relapse after adoptive NY-ESO-1-specific T-cell therapy.

  15. A cancer vaccine induces expansion of NY-ESO-1-specific regulatory T cells in patients with advanced melanoma.

    Science.gov (United States)

    Ebert, Lisa M; MacRaild, Sarah E; Zanker, Damien; Davis, Ian D; Cebon, Jonathan; Chen, Weisan

    2012-01-01

    Cancer vaccines are designed to expand tumor antigen-specific T cells with effector function. However, they may also inadvertently expand regulatory T cells (Treg), which could seriously hamper clinical efficacy. To address this possibility, we developed a novel assay to detect antigen-specific Treg based on down-regulation of surface CD3 following TCR engagement, and used this approach to screen for Treg specific to the NY-ESO-1 tumor antigen in melanoma patients treated with the NY-ESO-1/ISCOMATRIX™ cancer vaccine. All patients tested had Treg (CD25(bright) FoxP3(+) CD127(neg)) specific for at least one NY-ESO-1 epitope in the blood. Strikingly, comparison with pre-treatment samples revealed that many of these responses were induced or boosted by vaccination. The most frequently detected response was toward the HLA-DP4-restricted NY-ESO-1(157-170) epitope, which is also recognized by effector T cells. Notably, functional Treg specific for an HLA-DR-restricted epitope within the NY-ESO-1(115-132) peptide were also identified at high frequency in tumor tissue, suggesting that NY-ESO-1-specific Treg may suppress local anti-tumor immune responses. Together, our data provide compelling evidence for the ability of a cancer vaccine to expand tumor antigen-specific Treg in the setting of advanced cancer, a finding which should be given serious consideration in the design of future cancer vaccine clinical trials.

  16. Tetramer guided, cell sorter assisted production of clinical grade autologous NY-ESO-1 specific CD8(+) T cells.

    Science.gov (United States)

    Pollack, Seth M; Jones, Robin L; Farrar, Erik A; Lai, Ivy P; Lee, Sylvia M; Cao, Jianhong; Pillarisetty, Venu G; Hoch, Benjamin L; Gullett, Ashley; Bleakley, Marie; Conrad, Ernest U; Eary, Janet F; Shibuya, Kendall C; Warren, Edus H; Carstens, Jason N; Heimfeld, Shelly; Riddell, Stanley R; Yee, Cassian

    2014-01-01

    Adoptive T cell therapy represents an attractive modality for the treatment of patients with cancer. Peripheral blood mononuclear cells have been used as a source of antigen specific T cells but the very low frequency of T cells recognizing commonly expressed antigens such as NY-ESO-1 limit the applicability of this approach to other solid tumors. To overcome this, we tested a strategy combining IL-21 modulation during in vitro stimulation with first-in-class use of tetramer-guided cell sorting to generate NY-ESO-1 specific cytotoxic T lymphocytes (CTL). CTL generation was evaluated in 6 patients with NY-ESO-1 positive sarcomas, under clinical manufacturing conditions and characterized for phenotypic and functional properties. Following in vitro stimulation, T cells stained with NY-ESO-1 tetramer were enriched from frequencies as low as 0.4% to >90% after single pass through a clinical grade sorter. NY-ESO-1 specific T cells were generated from all 6 patients. The final products expanded on average 1200-fold to a total of 36 billion cells, were oligoclonal and contained 67-97% CD8(+), tetramer(+) T cells with a memory phenotype that recognized endogenous NY-ESO-1. This study represents the first series using tetramer-guided cell sorting to generate T cells for adoptive therapy. This approach, when used to target more broadly expressed tumor antigens such as WT-1 and additional Cancer-Testis antigens will enhance the scope and feasibility of adoptive T cell therapy.

  17. ESO 243-49 HLX-1: scaling of X-ray spectral properties and black hole mass determination

    CERN Document Server

    Titarchuk, Lev

    2016-01-01

    We report the results of Swift/XRT observations (2008-2015) of a hyper-luminous X-ray source, ESO 243-49 HLX-1. We found a strong observational evidence that ESO 243-49 HLX-1 underwent spectral transitions from the low/hard state to the high/soft state during these observations. The spectra of ESO 243-49 HLX-1 are well fitted by the so-{called} bulk motion Comptonization model for all spectral states. We have established the photon index Gamma saturation level, Gamma_{sat}$=3.0+/-0.1, in the correlation of Gamma versus mass accretion rate dot M. This Gamma-dot M correlation allows us to estimate the black hole (BH) mass in ESO 243-49 HLX-1 to be M_{BH}~ 7x 10^4 solar masses, assuming the distance to ESO 243-49 of 95 Mpc. For the BH mass estimate we used the scaling method, taking Galactic BHs XTE~J1550-564, H~1743-322 and 4U~1630-472, and an extragalactic BH source, M101 ULX-1 as reference sources. The Gamma-dot M correlation revealed in ESO 243-49 HLX-1 is similar to those in a number of Galactic and extraga...

  18. Préface

    Directory of Open Access Journals (Sweden)

    Sylvie Duvillard

    2010-09-01

    Full Text Available Le moment est opportun, la question foncière est de retour, légitimée par presque une décennie (2001-2008 d’augmentation continue des prix de l’immobilier. De « sommets » , en articles de presse, la montagne et les Alpes en particulier font l’objet, dans ce domaine, d’une attention toute particulière. Le contexte est ici délicat. Les sociétés alpines sont partagées entre désir de préservation d’une forte identité montagnarde et crainte d’une « déprise » économique (agricole, touristique et/...

  19. Préface

    Directory of Open Access Journals (Sweden)

    Hugues François

    2011-01-01

    Full Text Available Le changement climatique revêt en ce début de millénaire les habits de « mal du siècle » prédisant, à l’horizon 2100, un véritable cataclysme pour les sociétés humaines et leur organisation. Par delà le catastrophisme, les bouleversements induits par l’évolution du climat sur nos pratiques de gestion des territoires sont une réalité. Plus que de céder aux sirènes d’un discours alarmiste, il devient indispensable de se doter d’une meilleure connaissance des mécanismes de ces changements et d’e...

  20. Préface

    Directory of Open Access Journals (Sweden)

    Christian Ménard

    2009-10-01

    Full Text Available La piraterie est un phénomène fort complexe qui remonte à la nuit des temps. Déjà 5 000 ans avant J.-C., des exactions sont mentionnées en mer Egée et Méditerranée. Jules César en sera même l’une des célèbres victimes, mais saura prendre, au moment voulu, sa revanche. Tout au long des siècles, le processus restera récurrent (Atlantique, Antilles…, trouvant son apogée dans le premier quart du XIXe siècle avec l’intervention directe de l’U.S. Navy sous la férule de Thomas Jefferson, Président ...

  1. Présentation

    Directory of Open Access Journals (Sweden)

    Aurore Monod Becquelin

    2010-09-01

    Full Text Available Les recherches présentées dans ce volume sont issues des travaux de chercheurs qui se réunissent régulièrement depuis 2005 sur le thème de l’« Agentivité ». Ce groupe rassemble des ethnologues et des linguistes du Laboratoire d’ethnologie et de sociologie comparative (umr 7186, cnrs/université Paris Ouest Nanterre La Défense, du Laboratoire d’anthropologie sociale (umr 7130, Collège de France/ehess Paris/cnrs, de l’École des hautes études en sciences sociales, de l’Institut des hautes étude...

  2. Présentation

    OpenAIRE

    Anis, Jacques; Kleiber, Georges

    2011-01-01

    Présentation de Jacques Anis Michel Galmiche a toujours manifesté une certaine distance vis-à-vis des rites universitaires. Je ne sais pas s’il aurait apprécié l’idée que dix ans après sa disparition, la revue rende hommage à son cofondateur, qui, dans le trio constitué par Michel Arrivé, Rémy Porquier et lui-même fut chargé de transformer en image ce calembour grapho-phonique – Linguistique Institut Nanterre Paris X – dont est issu ce joli nom qui a provoqué quelques erreurs dans des bibliog...

  3. Présentation

    Directory of Open Access Journals (Sweden)

    Leger Claude-Louis

    2000-05-01

    Full Text Available Ce qui frappe aujourd’hui, c’est une évolution rapide des connaissances sur les quatre vitamines liposolubles qui font l’objet des revues générales présentées dans ce dossier, et plus particulièrement peut-être sur les vitamines A, D et E. On savait ces vitamines indispensables en raison de leur implication dans les réactions cellulaires, pas uniquement métaboliques d’ailleurs, mais on ne pouvait les soupçonner d’intervenir dans des phénomènes complexes touchant aux régulations cellulaires et à l’expression des gènes avant l’explosion des techniques de biologie moléculaire. Ces trois vitamines ont ainsi, entre autres, la capacité de réguler la prolifération et la différenciation cellulaire selon des mécanismes qui peuvent paraître différents aujourd’hui dans certains cas (pour la vitamine E par exemple, ou souvent proches (cas des vitamine A et D. Les quatre vitamines sont capables en revanche d’intervenir dans la mort cellulaire programmée (apoptose. Dans le cas du tissu osseux, ce sont les vitamines A, D et K qui agissent sur l’accrétion calcique. La vitamine E, quant à elle, pourrait prévenir, au moins théoriquement, l’ostéoporose.

  4. "Diversidad de estilos de aprendizaje en el aula de música de ESO" [Diversity of learning styles in the music classrroom of ESO

    Directory of Open Access Journals (Sweden)

    Vicente Simón Simón

    2011-01-01

    Full Text Available RESUMEN:El presente artículo pretende mostrar los resultados de una investigación llevada a cabo en un centro de enseñanzas medias de Castilla-La Mancha, el IES Airén de Tomelloso (Ciudad Real. En él se trata de relacionar los estilos de aprendizaje del alumnado de 1º ciclo de ESO con sus aplicaciones e implicaciones en el campo académico de una materia determinada, la Música. El trabajo se sustenta en los datos obtenidos a través de dos cuestionarios, uno de reconocido prestigio (CHAEA y otro de creación propia (ESTMUS que pretenden determinar las relaciones existentes entre los aprendizajes musicales y los estilos de aprendizaje. Los resultados confirmaron la validez de nuestro cuestionario al reconocerle cerca de un 75 % de coincidencia entre las respuestas de los alumnos de nuestra muestra. Aunque no se observó un estilo de aprendizaje claramente predominante, destacan las personas en las que predomina el estilo de aprendizaje reflexivo en ambos casos.ABSTRACT:This article aims to show the results of research conducted in secondary schools of Castilla-La Mancha, IES Airen of Tomelloso (Ciudad Real. It seeks to relate the learning styles of students of 1 cycle of ESO with its applications and implications in the academic field of a specific subject Music. The work is based on data obtained through two questionnaires, a prestigious (CHAE and one own creation (ESTMUS seeking to determine the relationship between music learning and learning styles. The results confirmed the validity of our questionnaire to recognize about 75% overlap between the responses of students in our sample. Although not observed clearly predominant learning style, outstanding people in the predominantly reflexive learning style in both cases.

  5. Implantes dentales para mejorar la biomecánica y estética de la prótesis parcial removible

    OpenAIRE

    Rengifo Alarcón, Carlos Alberto; Facultad de Estomatología, Universidad Peruana Cayetano Heredia. Lima,; Balarezo Razzeto, José Antonio; Facultad de Estomatología, Universidad Peruana Cayetano Heredia. Lima,; Matta Morales, Carlos; Facultad de Estomatología, Universidad Peruana Cayetano Heredia. Lima,; Vicente Zamudio, Eduardo Gregorio; Facultad de Estomatología, Universidad Peruana Cayetano Heredia. Lima,

    2014-01-01

    Existe un alto porcentaje de la población mundial que presenta algún grado de edentulismo parcial; es por eso que han surgido diferentes alternativas de tratamiento para poder solucionar y dar calidad de vida a estos pacientes. La prótesis parcial removible convencional surgieron en un inicio, para ayudar a estos pacientes, pero presentaban algunos inconvenientes en retención, soporte y estabilidad sobre todo en prótesis dentomucosoportadas, con la introducción de los implantes estos inconven...

  6. MHC class II/ESO tetramer-based generation of in vitro primed anti-tumor T-helper lines for adoptive cell therapy of cancer.

    Science.gov (United States)

    Poli, Caroline; Raffin, Caroline; Dojcinovic, Danijel; Luescher, Immanuel; Ayyoub, Maha; Valmori, Danila

    2013-02-01

    Generation of tumor-antigen specific CD4(+) T-helper (T(H)) lines through in vitro priming is of interest for adoptive cell therapy of cancer, but the development of this approach has been limited by the lack of appropriate tools to identify and isolate low frequency tumor antigen-specific CD4(+) T cells. Here, we have used recently developed MHC class II/peptide tetramers incorporating an immunodominant peptide from NY-ESO-1 (ESO), a tumor antigen frequently expressed in different human solid and hematologic cancers, to implement an in vitro priming platform allowing the generation of ESO-specific T(H) lines. We isolated phenotypically defined CD4(+) T-cell subpopulations from circulating lymphocytes of DR52b(+) healthy donors by flow cytometry cell sorting and stimulated them in vitro with peptide ESO(119-143), autologous APC and IL-2. We assessed the frequency of ESO-specific cells in the cultures by staining with DR52b/ESO(119-143) tetramers (ESO-tetramers) and TCR repertoire of ESO-tetramer(+) cells by co-staining with TCR variable β chain (BV) specific antibodies. We isolated ESO-tetramer(+) cells by flow cytometry cell sorting and expanded them with PHA, APC and IL-2 to generate ESO-specific T(H) lines. We characterized the lines for antigen recognition, by stimulation with ESO peptide or recombinant protein, cytokine production, by intracellular staining using specific antibodies, and alloreactivity, by stimulation with allo-APC. Using this approach, we could consistently generate ESO-tetramer(+) T(H) lines from conventional CD4(+)CD25(-) naïve and central memory populations, but not from effector memory populations or CD4(+)CD25(+) Treg. In vitro primed T(H) lines recognized ESO with affinities comparable to ESO-tetramer(+) cells from patients immunized with an ESO vaccine and used a similar TCR repertoire. In this study, using MHC class II/ESO tetramers, we have implemented an in vitro priming platform allowing the generation of ESO

  7. [Proceedings of the 5th Symposium on Mesozoic and Cenozoic Decapod Crustaceans, Krakow, Poland, 2013: A tribute to Pál Mihály Müller / R.H.B. Fraaije, M. Hyžný, J.W.M. Jagt, M. Krobicki & B.W.M. van Bakel (eds.)]: Two new Early Pliocene species of the crab genus Hyas Leach, 1814 (Majoidea, Oregoniidae) from northeast Japan

    NARCIS (Netherlands)

    Kato, H.; Nakashima, R.; Yanagisawa, Y.

    2014-01-01

    Two new species of the oregoniid crab genus Hyas are described from the Lower Pliocene of northern Japan, H. chippubetsuensis sp. nov. from the Chippubetsu Formation exposed along the Tadoshi River (Fukagawa City, central Hokkaido) and H. tentokujiensis sp. nov. from the Tentokuji Formation at Daise

  8. Dose-dependent effects of NY-ESO-1 protein vaccine complexed with cholesteryl pullulan (CHP-NY-ESO-1) on immune responses and survival benefits of esophageal cancer patients.

    Science.gov (United States)

    Kageyama, Shinichi; Wada, Hisashi; Muro, Kei; Niwa, Yasumasa; Ueda, Shugo; Miyata, Hiroshi; Takiguchi, Shuji; Sugino, Sahoko H; Miyahara, Yoshihiro; Ikeda, Hiroaki; Imai, Naoko; Sato, Eiichi; Yamada, Tomomi; Osako, Masaharu; Ohnishi, Mami; Harada, Naozumi; Hishida, Tadashi; Doki, Yuichiro; Shiku, Hiroshi

    2013-10-05

    Cholesteryl pullulan (CHP) is a novel antigen delivery system for cancer vaccines. This study evaluated the safety, immune responses and clinical outcomes of patients who received the CHP-NY-ESO-1 complex vaccine, Drug code: IMF-001. Patients with advanced/metastatic esophageal cancer were enrolled and subcutaneously vaccinated with either 100 μg or 200 μg of NY-ESO-1 protein complexed with CHP. The primary endpoints were safety and humoral immune responses, and the secondary endpoint was clinical efficacy. A total of 25 patients were enrolled. Thirteen and twelve patients were repeatedly vaccinated with 100 μg or 200 μg of CHP-NY-ESO-1 with a median of 8 or 9.5 doses, respectively. No serious adverse events related to the vaccine were observed. Three out of 13 patients in the 100-μg cohort and 7 out of 12 patients in the 200-μg cohort were positive for anti-NY-ESO-1 antibodies at baseline. In the 100-μg cohort, an antibody response was observed in 5 out of 10 pre-antibody-negatives patients, and the antibody levels were augmented in 2 pre-antibody-positive patients after vaccination. In the 200-μg cohort, all 5 pre-antibody-negative patients became seropositive, and the antibody level was amplified in all 7 pre-antibody-positive patients. No tumor shrinkage was observed. The patients who received 200 μg of CHP-NY-ESO-1 survived longer than patients receiving 100 μg of CHP-NY-ESO-1, even those who exhibited unresponsiveness to previous therapies or had higher tumor burdens. The safety and immunogenicity of CHP-NY-ESO-1 vaccine were confirmed. The 200 μg dose more efficiently induced immune responses and suggested better survival benefits. (Clinical trial registration number NCT01003808).

  9. Induction of CD8 T-cell responses restricted to multiple HLA class I alleles in a cancer patient by immunization with a 20-mer NY-ESO-1f (NY-ESO-1 91-110) peptide.

    Science.gov (United States)

    Eikawa, Shingo; Kakimi, Kazuhiro; Isobe, Midori; Kuzushima, Kiyotaka; Luescher, Immanuel; Ohue, Yoshihiro; Ikeuchi, Kazuhiro; Uenaka, Akiko; Nishikawa, Hiroyoshi; Udono, Heiichiro; Oka, Mikio; Nakayama, Eiichi

    2013-01-15

    Immunogenicity of a long 20-mer NY-ESO-1f peptide vaccine was evaluated in a lung cancer patient TK-f01, immunized with the peptide with Picibanil OK-432 and Montanide ISA-51. We showed that internalization of the peptide was necessary to present CD8 T-cell epitopes on APC, contrasting with the direct presentation of the short epitope. CD8 T-cell responses restricted to all five HLA class I alleles were induced in the patient after the peptide vaccination. Clonal analysis showed that B*35:01 and B*52:01-restricted CD8 T-cell responses were the two dominant responses. The minimal epitopes recognized by A*24:02, B*35:01, B*52:01 and C*12:02-restricted CD8 T-cell clones were defined and peptide/HLA tetramers were produced. NY-ESO-1 91-101 on A*24:02, NY-ESO-1 92-102 on B*35:01, NY-ESO-1 96-104 on B*52:01 and NY-ESO-1 96-104 on C*12:02 were new epitopes first defined in this study. Identification of the A*24:02 epitope is highly relevant for studying the Japanese population because of its high expression frequency (60%). High affinity CD8 T-cells recognizing tumor cells naturally expressing the epitopes and matched HLA were induced at a significant level. The findings suggest the usefulness of a long 20-mer NY-ESO-1f peptide harboring multiple CD8 T-cell epitopes as an NY-ESO-1 vaccine. Characterization of CD8 T-cell responses in immunomonitoring using peptide/HLA tetramers revealed that multiple CD8 T-cell responses comprised the dominant response. Copyright © 2012 UICC.

  10. 靶向克隆法构建NY-ESO-1基因的原核表达载体%Construction of NY-ESO-1 Gene Prokaryotic Expression Vector by LP Recco PCR Cloning

    Institute of Scientific and Technical Information of China (English)

    俞远东; 徐少勇; 王斌; 王家宁; 黄永章

    2009-01-01

    目的:利用PCR产物靶向克隆法构建人癌-睾丸抗原NY-ESO-1的原核表达载体.方法:从人新鲜的食管癌组织中提取总RNA,通过RT-PCR技术扩增NY-ESO-1基因3'端的340 bp片段,采用靶向克隆法将目的基因插入到原核表达载体pET-15b中,得到重组表达质粒pET-15b-NY-ESO-1,经过筛选,挑选出阳性克隆进行Xho Ⅰ和BamHⅠ双酶切图谱分析、PCR检测和扩增产物核苷酸序列分析等,鉴定所构建的原核表达载体.结果:扩增得到NY-ESO-1基因片段,经测序证实与GenBank公布的序列一致,重组的质粒经过PCR,酶切鉴定获得了一个大小为340 bp的特征性片段,证明重组质粒中已成功的插入了目的基因NY-ESO-1.结论:靶向克隆法可快速、高效地构建人NY-ESO-1基因的原核表达载体,为制备pET-15b-NY-ESO-1融合蛋白奠定了基础.

  11. Efficient in vivo priming by vaccination with recombinant NY-ESO-1 protein and CpG in antigen naive prostate cancer patients.

    Science.gov (United States)

    Karbach, Julia; Neumann, Antje; Atmaca, Akin; Wahle, Claudia; Brand, Kathrin; von Boehmer, Lotta; Knuth, Alexander; Bender, Armin; Ritter, Gerd; Old, Lloyd J; Jäger, Elke

    2011-02-15

    NY-ESO-1, one of the most immunogenic tumor antigens, is expressed in 15% to 25% of metastatic prostate cancers. The immunological and clinical effects of vaccination with recombinant NY-ESO-1 protein combined with CpG as adjuvant were evaluated. In a phase I clinical study, patients with advanced prostate cancer were vaccinated with recombinant NY-ESO-1 protein (100 μg) mixed with CpG 7909 (2.5 mg) every 3 weeks intradermally for 4 doses. Objectives of the study were the safety of the vaccine and changes of specific humoral and cellular immunological responses to NY-ESO-1 in relation to detectable NY-ESO-1 expression in the individual tumor. All 12 baseline sero-negative patients developed high-titer NY-ESO-1 antibody responses. B-cell epitope mapping identified NY-ESO-1 p91-110 to be recognized most frequently by vaccine-induced antibodies. Two patients developed significant antibody titers against the adjuvant CpG. NY-ESO-1-specific CD4+ and/or CD8+ T-cell responses were induced in 9 patients (69%). Five of these 9 patients did not express NY-ESO-1 in the autologous tumor. Postvaccine CD8+ T-cell clones recognized and lyzed HLA-matched tumor cell lines in an antigen-specific manner. Our data provide clear evidence for the capacity of NY-ESO-1 protein/CpG vaccine to induce integrated antigen-specific immune responses in vivo and to efficiently prime CD8+ T-cell responses in NY-ESO-1 antigen-negative patients. Our results may also support further clinical vaccination protocols with NY-ESO-1 protein not only focused on the treatment of existing cancer, but also to prevent further development of NY-ESO-1 positive cancers in vivo. ©2010 AACR.

  12. Main: PR2GCNT [PLACE

    Lifescience Database Archive (English)

    Full Text Available PR2GCNT S000089 10-May-1998 (last modified) kehi GC element conserved in the 5' ups...N.t.); tobacco; group 2; pr-protein; GC element; chitinase; beta-1,3-glucanase; tobacco (Nicotiana tabacum); TAARAGCCGCC ...

  13. Definition of key variables for the induction of optimal NY-ESO-1-specific T cells in HLA transgene mice.

    Science.gov (United States)

    Johannsen, Alexandre; Genolet, Raphaël; Legler, Daniel F; Luther, Sanjiv A; Luescher, Immanuel F

    2010-09-15

    An attractive treatment of cancer consists in inducing tumor-eradicating CD8(+) CTL specific for tumor-associated Ags, such as NY-ESO-1 (ESO), a strongly immunogenic cancer germ line gene-encoded tumor-associated Ag, widely expressed on diverse tumors. To establish optimal priming of ESO-specific CTL and to define critical vaccine variables and mechanisms, we used HLA-A2/DR1 H-2(-/-) transgenic mice and sequential immunization with immunodominant DR1- and A2-restricted ESO peptides. Immunization of mice first with the DR1-restricted ESO(123-137) peptide and subsequently with mature dendritic cells (DCs) presenting this and the A2-restriced ESO(157-165) epitope generated abundant, circulating, high-avidity primary and memory CD8(+) T cells that efficiently killed A2/ESO(157-165)(+) tumor cells. This prime boost regimen was superior to other vaccine regimes and required strong Th1 cell responses, copresentation of MHC class I and MHC class II peptides by the same DC, and resulted in upregulation of sphingosine 1-phosphate receptor 1, and thus egress of freshly primed CD8(+) T cells from the draining lymph nodes into circulation. This well-defined system allowed detailed mechanistic analysis, which revealed that 1) the Th1 cytokines IFN-gamma and IL-2 played key roles in CTL priming, namely by upregulating on naive CD8(+) T cells the chemokine receptor CCR5; 2) the inflammatory chemokines CCL4 (MIP-1beta) and CCL3 (MIP-1alpha) chemoattracted primed CD4(+) T cells to mature DCs and activated, naive CD8(+) T cells to DC-CD4 conjugates, respectively; and 3) blockade of these chemokines or their common receptor CCR5 ablated priming of CD8(+) T cells and upregulation of sphingosine 1-phosphate receptor 1. These findings provide new opportunities for improving T cell cancer vaccines.

  14. Combination of autoantibodies against NY-ESO-1 and viral capsid antigen immunoglobulin A for improved detection of nasopharyngeal carcinoma.

    Science.gov (United States)

    Peng, Yu-Hui; Xu, Yi-Wei; Qiu, Si-Qi; Hong, Chao-Qun; Zhai, Tian-Tian; Li, En-Min; Xu, Li-Yan

    2014-09-01

    Nasopharyngeal carcinoma (NPC) is one of the most common malignant tumors in Southern China and Southeast Asia, and early detection remains a challenge. Autoantibodies have been found to precede the manifestations of symptomatic cancer by several months to years, making their identification of particular relevance for early detection. In the present study, the diagnostic value of serum autoantibodies against NY-ESO-1 in NPC patients was evaluated. The study included 112 patients with NPC and 138 normal controls. Serum levels of autoantibodies against NY-ESO-1 and classical Epstein-Barr virus marker, viral capsid antigen immunoglobulin A (VCA-IgA), were measured by enzyme-linked immunosorbent assay. Measurement of autoantibodies against NY-ESO-1 and VCA-IgA demonstrated a sensitivity/specificity of 42.9/94.9% [95% confidence interval (CI), 33.7-52.6/89.4-97.8%] and 55.4/95.7% (95% CI, 45.7-64.7/90.4-98.2%), respectively. The area under receiver operating characteristic curve for autoantibodies against NY-ESO-1 (0.821; 95% CI, 0.771-0.871) was marginally lower than that for VCA-IgA (0.860; 95% CI, 0.810-0.910) in NPC. The combination of autoantibodies against NY-ESO-1 and VCA-IgA yielded an enhanced sensitivity of 80.4% (95% CI, 71.6-87.0%) and a specificity of 90.6% (95% CI, 84.1-94.7%). Moreover, detection of autoantibodies against NY-ESO-1 could differentiate early-stage NPC patients from normal controls. Our results suggest that autoantibodies against NY-ESO-1 may serve as a potential biomarker, as a supplement to VCA-IgA, for the screening and diagnosis of NPC.

  15. Cancer-testis antigen expression in synovial sarcoma: NY-ESO-1, PRAME, MAGEA4, and MAGEA1.

    Science.gov (United States)

    Iura, Kunio; Maekawa, Akira; Kohashi, Kenichi; Ishii, Takeaki; Bekki, Hirofumi; Otsuka, Hiroshi; Yamada, Yuichi; Yamamoto, Hidetaka; Harimaya, Katsumi; Iwamoto, Yukihide; Oda, Yoshinao

    2017-03-01

    Synovial sarcoma (SS) is regarded as a relatively chemosensitive sarcoma, but the prognosis of advanced SSs remains poor. Here we identified highly expressed cancer-testis antigens that could be promising immunotherapy targets for SS, using a previously conducted cDNA microarray, and we assessed the clinicopathological or prognostic relationships of these antigens in SS. We compared the gene expression profiles of 11 SSs with those of 3 normal adipose tissues. Among the up-regulated cancer-testis antigens, we analyzed PRAME, MAGEA1, and MAGEA4 and another cancer-testis antigen (NY-ESO-1) together, by immunohistochemistry and real-time polymerase chain reaction in 108 SSs. Immunohistochemically, NY-ESO-1, PRAME, MAGEA4, and MAGEA1 were positive in 66 (61%), 93 (86%), 89 (82%), and 16 (15%) of 108 SSs, respectively, and 104 (96%) of 108 SSs showed the immunohistochemical expression of at least 1 of NY-ESO-1, PRAME, and MAGEA4. Moreover, the high expression of at least 1 of these 3 antigens was observed in 83% of the SSs. High expression of NY-ESO-1 and MAGEA4 was significantly correlated with the presence of necrosis and advanced clinical stage. The immunohistochemical expression of these cancer-testis antigens was not correlated with prognosis, but the coexpression of NY-ESO-1, PRAME, and MAGEA4 was significantly associated with adverse prognosis. The real-time polymerase chain reaction results were closely related to the immunohistochemical results: NY-ESO-1 (P = .0019), PRAME (P = .039), MAGEA4 (P = .0149), and MAGEA1 (P = .0766). These data support the potential utility of NY-ESO-1, PRAME, and MAGEA4 as immunotherapy targets and ancillary prognostic parameters, suggesting the possible benefit of the combined use of these cancer-testis antigens as an SS immunotherapy target. Copyright © 2016 Elsevier Inc. All rights reserved.

  16. Functional autoantibodies against SSX-2 and NY-ESO-1 in multiple myeloma patients after allogeneic stem cell transplantation.

    Science.gov (United States)

    Luetkens, Tim; Kobold, Sebastian; Cao, Yanran; Ristic, Marina; Schilling, Georgia; Tams, Sinje; Bartels, Britta Marlen; Templin, Julia; Bartels, Katrin; Hildebrandt, York; Yousef, Sara; Marx, Andreas; Haag, Friedrich; Bokemeyer, Carsten; Kröger, Nicolaus; Atanackovic, Djordje

    2014-11-01

    Multiple myeloma (MM) is the malignancy with the most frequent expression of the highly immunogenic cancer-testis antigens (CTA), and we have performed the first analysis of longitudinal expression, immunological properties, and fine specificity of CTA-specific antibody responses in MM. Frequency and characteristics of antibody responses against cancer-testis antigens MAGE-A3, NY-ESO-1, PRAME, and SSX-2 were analyzed using peripheral blood (N = 1094) and bone marrow (N = 200) plasma samples from 194 MM patients. We found that antibody responses against CTA were surprisingly rare, only 2.6 and 3.1 % of patients evidenced NY-ESO-1- and SSX-2-specific antibodies, respectively. NY-ESO-1-specific responses were observed during disease progression, while anti-SSX-2 antibodies appeared after allogeneic stem cell transplantation and persisted during clinical remission. We found that NY-ESO-1- and SSX-2-specific antibodies were both capable of activating complement and increasing CTA uptake by antigen-presenting cells. SSX-2-specific antibodies were restricted to IgG3, NY-ESO-1 responses to IgG1 and IgG3. Remarkably, NY-ESO-1-positive sera recognized various non-contiguous regions, while SSX-2-specific responses were directed against a single 6mer epitope, SSX-2(85-90). We conclude that primary autoantibodies against intracellular MM-specific tumor antigens SSX-2 and NY-ESO-1 are rare but functional. While their contribution to disease control still remains unclear, our data demonstrate their theoretic ability to affect cellular anti-tumor immunity by formation and uptake of mono- and polyvalent immune complexes.

  17. The Gaia-ESO Survey: A globular cluster escapee in the Galactic halo

    Science.gov (United States)

    Lind, K.; Koposov, S. E.; Battistini, C.; Marino, A. F.; Ruchti, G.; Serenelli, A.; Worley, C. C.; Alves-Brito, A.; Asplund, M.; Barklem, P. S.; Bensby, T.; Bergemann, M.; Blanco-Cuaresma, S.; Bragaglia, A.; Edvardsson, B.; Feltzing, S.; Gruyters, P.; Heiter, U.; Jofre, P.; Korn, A. J.; Nordlander, T.; Ryde, N.; Soubiran, C.; Gilmore, G.; Randich, S.; Ferguson, A. M. N.; Jeffries, R. D.; Vallenari, A.; Allende Prieto, C.; Pancino, E.; Recio-Blanco, A.; Romano, D.; Smiljanic, R.; Bellazzini, M.; Damiani, F.; Hill, V.; de Laverny, P.; Jackson, R. J.; Lardo, C.; Zaggia, S.

    2015-03-01

    A small fraction of the halo field is made up of stars that share the light element (Z ≤ 13) anomalies characteristic of second generation globular cluster (GC) stars. The ejected stars shed light on the formation of the Galactic halo by tracing the dynamical history of the clusters, which are believed to have once been more massive. Some of these ejected stars are expected to show strong Al enhancement at the expense of shortage of Mg, but until now no such star has been found. We search for outliers in the Mg and Al abundances of the few hundreds of halo field stars observed in the first eighteen months of the Gaia-ESO public spectroscopic survey. One halo star at the base of the red giant branch, here referred to as 22593757-4648029 is found to have [ Mg/Fe ] = -0.36 ± 0.04 and [ Al/Fe ] = 0.99 ± 0.08, which is compatible with the most extreme ratios detected in GCs so far. We compare the orbit of 22593757-4648029 to GCs of similar metallicity andfind it unlikely that this star has been tidally stripped with low ejection velocity from any of the clusters. However, both chemical and kinematic arguments render it plausible that the star has been ejected at high velocity from the anomalous GC ω Centauri within the last few billion years. We cannot rule out other progenitor GCs, because some may have disrupted fully, and the abundance and orbital data are inadequate for many of those that are still intact. Based on data acquired by the Gaia-ESO Survey, programme ID 188.B-3002. Observations were made with ESO Telescopes at the La Silla Paranal Observatory.Appendix A is available in electronic form at http://www.aanda.org

  18. Préface

    Science.gov (United States)

    Aspect, Alain

    2004-11-01

    COLOQ est une conférence regroupant, tous les deux ans, la communauté scientifique et industrielle nationale travaillant dans les domaines des lasers, de l'optique non-linéaire et de l'optique quantique. Elle s'est tenue pour sa huitième édition à Toulouse, du 3 au 5 septembre 2004, sur le campus de I'INSA. Comme il est de tradition tous les quatre ans, COLOQ était couplé avec Horizons de l'optique, avec en particulier une journée commune dont le programme avait été préparé en concertation par les deux comités scientifiques. Depuis sa création, COLOQ a pour but de favoriser les rencontres entre les chercheurs des différents laboratoires nationaux publics ou privés travaillant sur les lasers et l'optique quantique au sens large. C'est un moyen privilégié de resserrer les liens de cette communauté et d'y intégrer les jeunes chercheurs. Ces derniers y trouvent l'occasion de se connaître, de se faire connaître, de découvrir la communauté à laquelle ils appartiennent et d'élargir leurs connaissances des thèmes qui la structurent. La participation de 230 chercheurs et d'une vingtaine d'exposants de matériels spécialisés dans les lasers et l'optoélectronique témoigne de la vitalité de COLOQ et de son audience dans les laboratoires et chez les industriels de l'optique. Le programme de COLOQ 8 comportait d'une vingtaine de conférences générales données par des chercheurs de renom international, et des séances de communications par affiches, occasions privilégiées de rencontres et d'échanges. Les exposés ont porté sur des sujets particulièrement actifs au niveau national et international, avec un accent sur des thèmes importants pour la région toulousaine : contrôle cohérent, optique et nanosciences, optique et astronomie, sans oublier la traditionnelle rubrique phénomènes fondamentaux, éclectique pour ne pas dire hétéroclite, mais si représentative d'une des ambitions de COLOQ qui est d'offrir à ses participants une

  19. PSN J17484870-6042193 a supernova candidate by TAROT in ESO 139-28

    Science.gov (United States)

    Klotz, A.

    2012-06-01

    From images taken on 2012 June 21.27 with the TAROT La Silla telescope we report the discovery of a supernova candidate located at R.A. = 17h48m48.7s, Decl. = -60o42'19.3" (equinox 2000.0), which is offset of 17" W and 4" N from the nucleus of ESO 139-28. The image was R filtered and magnitude was R=14.7. The presence of the candidate is confirmed on images taken on 2012 June 24.27 with the same telescope.

  20. Gaia benchmark stars and their twins in the Gaia-ESO Survey

    Science.gov (United States)

    Jofré, P.

    2016-09-01

    The Gaia benchmark stars are stars with very precise stellar parameters that cover a wide range in the HR diagram at various metallicities. They are meant to be good representative of typical FGK stars in the Milky Way. Currently, they are used by several spectroscopic surveys to validate and calibrate the methods that analyse the data. I review our recent activities done for these stars. Additionally, by applying our new method to find stellar twins on the Gaia-ESO Survey, I discuss how good representatives of Milky Way stars the benchmark stars are and how they distribute in space.

  1. Strong lens search in the ESO public Survey KiDS

    CERN Document Server

    Napolitano, N R; Roy, N; Tortora, C; La Barbera, F; Radovich, M; Getman, F; Capaccioli, M; Colonna, A; Paolillo, M; Kleijn, G A Verdoes; Koopmans, L V E

    2015-01-01

    We have started a systematic search of strong lens candidates in the ESO public survey KiDS based on the visual inspection of massive galaxies in the redshift range $0.1

  2. Highlights from the CERN/ESO/NordForsk ''Gender in Physics Day''

    Science.gov (United States)

    Primas, F.; Guinot, G.; Strandberg, L.

    2017-03-01

    In their role as observers on the EU Gender Equality Network in the European Research Area (GENERA) project, funded under the Horizon 2020 framework, CERN, ESO and NordForsk joined forces and organised a Gender in Physics Day at the CERN Globe of Science and Innovation. The one-day conference aimed to examine innovative activities promoting gender equality, and to discuss gender-oriented policies and best practice in the European Research Area (with special emphasis on intergovernmental organisations), as well as the importance of building solid networks. The event was very well attended and was declared a success. The main highlights of the meeting are reported.

  3. Gaia Benchmark stars and their twins in the Gaia-ESO Survey

    CERN Document Server

    Jofre, Paula

    2015-01-01

    The Gaia benchmark stars are stars with very precise stellar parameters that cover a wide range in the HR diagram at various metallicities. They are meant to be good representative of typical FGK stars in the Milky Way. Currently, they are used by several spectroscopic surveys to validate and calibrate the methods that analyse the data. I review our recent activities done for these stars. Additionally, by applying our new method to find stellar twins on the Gaia-ESO Survey, I discuss how good representatives of Milky Way stars the benchmark stars are and how they distribute in space.

  4. ASASSN-17ka: Discovery of A Probable Supernova in ESO 244-G 019

    Science.gov (United States)

    Monard, L. A. G.; Brimacombe, J.; Brown, J. S.; Stanek, K. Z.; Holoien, T. W.-S.; Kochanek, C. S.; Shields, J.; Thompson, T. A.; Shappee, B. J.; Prieto, J. L.; Bersier, D.; Dong, Subo; Bose, S.; Chen, Ping; Bock, G.; Fernandez, J. M.; Kiyota, S.; Masi, G.; Post, R. S.

    2017-07-01

    During the ongoing All Sky Automated Survey for SuperNovae (ASAS-SN, Shappee et al. 2014), using data from the quadruple 14-cm "Cassius" telescope in Cerro Tololo, Chile, we discovered a new transient source, most likely a supernova, in the galaxy ESO 244-G 019. ASASSN-17ka (AT 2017frr) was discovered in images obtained on UT 2017-07-27.23 at V 16.5 mag. We also detect the object in images obtained on UT 2017-07-24.24 (V 16.6), UT 2017-07-29.23 (V 16.0), and UT 2017-07-30.23 (V 16.5).

  5. ASASSN-17bu: Discovery of A Probable Supernova in ESO 375-G 018

    Science.gov (United States)

    Bock, G.; Brown, J. S.; Stanek, K. Z.; Holoien, T. W.-S.; Kochanek, C. S.; Shields, J.; Thompson, T. A.; Shappee, B. J.; Prieto, J. L.; Bersier, D.; Dong, Subo; Bose, S.; Chen, Ping; Brimacombe, J.; Cruz, I.; Fernandez, J. M.; Kiyota, S.; Koff, R. A.; Krannich, G.; Masi, G.; Nicholls, B.; Post, R. S.; Stone, G.

    2017-02-01

    During the ongoing All Sky Automated Survey for SuperNovae (ASAS-SN or "Assassin"), using data from the quadruple 14-cm "Cassius" telescope in Cerro Tololo, Chile, we discovered a new transient source, most likely a supernova, in the galaxy ESO 375-G 018. ASASSN-17bu (AT 2017yv) was discovered in images obtained on UT 2017-01-31.19 at V 16.6 mag. We also detect the object in images obtained on UT 2017-01-29.21 (V 17.1).

  6. LA EDUCACIÓN PARA LA SALUD EN LA ESO: APORTACIONES DE UN ESTUDIO SOBRE EL PAÍS VASCO

    Directory of Open Access Journals (Sweden)

    Amando Vega Fuente

    2015-01-01

    Full Text Available La educación para la salud en las escuelas es una estrategia necesaria para favorecer comportamientos saludables en el alumnado. Este estudio tiene como objetivo disponer de un conocimiento más preciso sobre las conductas de riesgo de los adolescentes y sobre el tratamiento de las cuestiones de salud en los centros de educación secundaria obligatoria. La prevención del consumo de drogas, la educación afectivo-sexual, la formación para la seguridad vial, la promoción de la salud física y mental son algunos de los aspectos clave para el desarrollo integral de los adolescentes. El trabajo de investigación se llevó a cabo en 24 institutos de ESO del País Vasco y han tomado parte 571 estudiantes. Todos ellos han participado en los programas de educación para la salud subvencionados por el Departamento de Educación del Gobierno Vasco durante los cursos 2010-11 y 2011-12. Los datos obtenidos mediante cuestionarios fueron tratados con el paquete informático SPSS 19.0 e ITEMAN realizándose diversos análisis estadísticos (porcentajes y correlaciones de Pearson. Los resultados obtenidos muestran que las conductas no saludables de los alumnos y alumnas no sólo están relacionadas entre sí, sino también con su bienestar personal y escolar. Se constata, por otra parte, una necesidad clara de que los centros escolares asuman un mayor compromiso con la educación y la promoción de la salud en sus proyectos educativos. Se echa en falta la integración de las cuestiones de salud en los proyectos de los centros, por razones varias, como la falta de una política comprometida con este ámbito educativo, las carencias de formación de los profesores y profesoras y posiblemente la insuficiencia de los recursos dedicados en los centros a la práctica educativa en temas de salud.

  7. Préface

    Science.gov (United States)

    Ouerdane, Youcef; Laporte, Pierre

    2005-06-01

    L'objectif de la série de colloques UVX est de réunir, au rythme d'une fois tous les deux ans, les scientifiques et industriels travaillant dans le domaine du développement des sources de photon de grande énergie (UV, VUV, et X) et de leurs applications. En particulier cette manifestation est l'occasion de faire se rencontrer une communauté très pluridisciplinaire (physique, chimie, biologie, sciences de l'univers) liée à des domaines en forte évolution technologique (lasers et rayonnement synchrotron notamment). Le colloque UVX 2004 s'est tenu au Palais des Congrès de Saint-Étienne (42000) du 7 au 11 juin 2004. La période écoulée depuis l'édition précédente (Oléron 2002) a été particulièrement active dans tous les domaines concernés : grands projets de sources, méthodes de diagnostic au sens large. Une nouvelle fois on constate que le bref et l'ultra-bref ont une place privilégiée, qu'il s'agisse du travail sur les accélérateurs ou sur les lasers qui, bien sûr, dans la course aux temps courts remportent la palme avec la présence de spécialistes du domaine attoseconde. La communauté représentée a la chance d'être en prise directe avec de très grands projets en phase active de réalisation comme le Laser Megajoule (LMJ), la source SOLEIL, et un projet d'ampleur plus modeste mais remarquable dans son domaine : la source LASERIX d'Orsay/Palaiseau. On pourra citer aussi le projet Arc en Ciel qui, lui, est encore au stade de sa définition. - SOLEIL, source de nouvelle génération de rayonnement synchrotron (plateau de Saclay) est dans une phase active de réalisation : achèvement de l'infrastructure en 2005 et injection du 1o faisceau dans l'anneau de stockage prévu également en 2005. Cette source devrait être la meilleure au monde dans le domaine VUV/X mous, tout en restant très polyvalente (brillance, accordabilité, structure temporelle, polarisation) et complémentaire de l'ESRF. Au final on disposera de 21 lignes de lumi

  8. Préface

    Science.gov (United States)

    Schober, Helmut; Fischer, Henry; Leclercq-Hugeux, Françoise

    2003-09-01

    L'École Thématique “Structure et Dynamique des Systèmes Désordonnés” [1] s'inscrit dans le cadre des écoles organisées sous l'impulsion de la Société Française de la Neutronique (SFN). Elle s'est deroulée en mai 2002 sur la Presqu'île de Giens (Var) en première partie des 11émes Journées de la Diffusion Neutronique. L'Édition de ces cours constitue ainsi le cinquième ouvrage introduisant les techniques neutroniques et leurs apports à differentes thématiques [2]. Le désordre est un facteur déterminant pour pratiquement toutes les propriétés des matériaux. Il est inhérent dans les matériaux amorphes ou liquides, mais il détermine également les propriétés mécaniques et électroniques d'autres composés d'importance technologique comme les matériaux métalliques, dont l'aspect “désordonné” est moins évident. Le désordre enfin joue un rôle essentiel dans tout ce que touche à la vie. En fait, il est difficile d'imaginer des systèmes, à part quelques exceptions rares comme l'hélium ou le silicium de haute pureté, où il n'y ait pas de désordre. En dehors de cet aspect pratique, la description scientifique du désordre atomique pose toujours des problèmes fondamentaux faute de concepts pertinents. Une des tâches importantes du scientifique ou de l'ingenieur est de préciser quel genre de désordre existe à une échelle d'espace et de temps donnée. Un materiau peut très bien être homogène à l'échelle atomique et présenter des défauts ou des hétrogéneité visibles à l'œil et inversement. De même, un système désordonné à un instant donné, peut apparaître ordonné si on moyenne dans le temps. Les techniques de diffusion des neutrons sont idéales pour aborder ces questions. Les neutrons sondent directement les noyaux et ont à la fois des longueurs d'ondes proches des distances inter atomiques et des énergies avoisinant celles des excitations élémentaires de la matière condensée. Ils permettent ainsi

  9. NY-ESO-1 Vaccination in Combination with Decitabine Induces Antigen-Specific T-Lymphocyte Responses in Patients with Myelodysplastic Syndrome.

    Science.gov (United States)

    Griffiths, Elizabeth A; Srivastava, Pragya; Matsuzaki, Junko; Brumberger, Zachary; Wang, Eunice S; Kocent, Justin; Miller, Austin; Roloff, Gregory W; Wong, Hong Yuen; Paluch, Benjamin E; Lutgen-Dunckley, Linda G; Martens, Brandon L; Odunsi, Kunle; Karpf, Adam R; Hourigan, Christopher S; Nemeth, Michael J

    2017-09-25

    Treatment options are limited for patients with high-risk myelodysplastic syndrome (MDS). The azanucleosides, azacitidine and decitabine, are front-line therapy for MDS that induce promoter demethylation and gene expression of the highly immunogenic tumor antigen NY-ESO-1. We demonstrated that AML patients receiving decitabine exhibit induction of NY-ESO-1 expression in circulating blasts. We hypothesized that vaccinating against NY-ESO-1 in MDS patients receiving decitabine would capitalize upon induced NY-ESO-1 expression in malignant myeloid cells to provoke an NY-ESO-1-specific-MDS directed cytotoxic T-cell immune response. In a phase I study, 9 MDS patients received an HLA unrestricted NY-ESO-1 vaccine (CDX-1401 + poly-ICLC) in a non-overlapping schedule every four weeks with standard dose decitabine. Analysis of samples serially obtained from the 7 patients who reached the end-of-study demonstrated induction of NY-ESO-1 expression in 7/7 patients and NY-ESO-1 specific CD4+ and CD8+ T-lymphocyte responses in 6/7 and 4/7 of the vaccinated patients respectively. Myeloid cells expressing NY-ESO-1, isolated from a patient at different time-points during decitabine therapy, were capable of activating a cytotoxic response from autologous NY-ESO-1-specific T-lymphocytes. Vaccine responses were associated with a detectable population of CD141Hi conventional dendritic cells, which are critical for the uptake of NY-ESO-1 vaccine and have a recognized role in anti-tumor immune responses. These data indicate that vaccination against induced NY-ESO-1 expression can produce an antigen-specific immune response in a relatively non-immunogenic myeloid cancer and highlight the potential for induced-antigen directed immunotherapy in a group of patients with limited options. Copyright ©2017, American Association for Cancer Research.

  10. Decitabine immunosensitizes human gliomas to NY-ESO-1 specific T lymphocyte targeting through the Fas/Fas Ligand pathway

    Science.gov (United States)

    2011-01-01

    Background The lack of effective treatments for gliomas makes them a significant health problem and highlights the need for the development of novel and innovative treatment approaches. Immunotherapy is an appealing strategy because of the potential ability for immune cells to traffic to and destroy infiltrating tumor cells. However, the absence of well-characterized, highly immunogenic tumor-rejection antigens (TRA) in gliomas has limited the implementation of targeted immune-based therapies. Methods We hypothesized that treatment with the demethylating agent, decitabine, would upregulate the expression of TRA on tumor cells, thereby facilitating enhanced surveillance by TRA-specific T cells. Results and Discussion Treatment of human glioma cells with decitabine increased the expression of NY-ESO-1 and other well characterized cancer testes antigens. The upregulation of NY-ESO-1 made these tumors susceptible to NY-ESO-1-specific T-cell recognition and lysis. Interestingly, decitabine treatment of T98 glioma cells also sensitized them to Fas-dependent apoptosis with an agonistic antibody, while a Fas blocking antibody could largely prevent the enhanced functional recognition by NY-ESO-1 specific T cells. Thus, decitabine treatment transformed a non-immunogenic glioma cell into an immunogenic target that was efficiently recognized by NY-ESO-1--specific T cells. Conclusions Such data supports the hypothesis that agents which alter epigenetic cellular processes may "immunosensitize" tumor cells to tumor-specific T cell-mediated lysis. PMID:22060015

  11. MAGE-A is More Highly Expressed Than NY-ESO-1 in a Systematic Immunohistochemical Analysis of 3668 Cases.

    Science.gov (United States)

    Kerkar, Sid P; Wang, Zeng-Feng; Lasota, Jerzy; Park, Tristen; Patel, Krishna; Groh, Eric; Rosenberg, Steven A; Miettinen, Markku M

    2016-05-01

    Two cancer testis antigens, the New York esophageal squamous cell carcinoma-1 (NY-ESO-1) and the melanoma-antigen family A (MAGE-A), represent promising immunotherapy targets due to the low expression of these antigens in nonmalignant tissue. To assess overexpression patterns in various cancers, we performed a systematic immunohistochemical analysis for NY-ESO-1 and MAGE-A on tissue array samples of 3668 common epithelial carcinomas (CA) and germ cell tumors of high prevalence and mortality. Here, we find significantly higher expression of MAGE-A (>50% on tumor cells) compared with NY-ESO-1 in several CAs including cutaneous squamous cell carcinomas (SCC) (52.8%/2.8%), esophageal SCC (50%/0%), head and neck SCC (41.1%/ESO-1, was seen in whole slide evaluations of an independent cohort of metastatic SCC (45.5%/3.6%) and metastatic CA (13.5%/0%) of various primaries with significantly higher expression of MAGE-A in metastatic SCC compared with other metastatic CA. MAGE-A is also more highly expressed in germ cell tumors, seminomas (69%/3.5%) and nonseminomas (40.1%/4.7%). In summary, MAGE-A is more highly expressed than NY-ESO-1 in a majority of human malignancies, and targeting MAGE-A may benefit a large number of patients.

  12. Decitabine immunosensitizes human gliomas to NY-ESO-1 specific T lymphocyte targeting through the Fas/Fas Ligand pathway

    Directory of Open Access Journals (Sweden)

    Konkankit Veerauo V

    2011-11-01

    Full Text Available Abstract Background The lack of effective treatments for gliomas makes them a significant health problem and highlights the need for the development of novel and innovative treatment approaches. Immunotherapy is an appealing strategy because of the potential ability for immune cells to traffic to and destroy infiltrating tumor cells. However, the absence of well-characterized, highly immunogenic tumor-rejection antigens (TRA in gliomas has limited the implementation of targeted immune-based therapies. Methods We hypothesized that treatment with the demethylating agent, decitabine, would upregulate the expression of TRA on tumor cells, thereby facilitating enhanced surveillance by TRA-specific T cells. Results and Discussion Treatment of human glioma cells with decitabine increased the expression of NY-ESO-1 and other well characterized cancer testes antigens. The upregulation of NY-ESO-1 made these tumors susceptible to NY-ESO-1-specific T-cell recognition and lysis. Interestingly, decitabine treatment of T98 glioma cells also sensitized them to Fas-dependent apoptosis with an agonistic antibody, while a Fas blocking antibody could largely prevent the enhanced functional recognition by NY-ESO-1 specific T cells. Thus, decitabine treatment transformed a non-immunogenic glioma cell into an immunogenic target that was efficiently recognized by NY-ESO-1--specific T cells. Conclusions Such data supports the hypothesis that agents which alter epigenetic cellular processes may "immunosensitize" tumor cells to tumor-specific T cell-mediated lysis.

  13. Recombinant Lactobacillus plantarum induces immune responses to cancer testis antigen NY-ESO-1 and maturation of dendritic cells.

    Science.gov (United States)

    Mobergslien, Anne; Vasovic, Vlada; Mathiesen, Geir; Fredriksen, Lasse; Westby, Phuong; Eijsink, Vincent G H; Peng, Qian; Sioud, Mouldy

    2015-01-01

    Given their safe use in humans and inherent adjuvanticity, Lactic Acid Bacteria may offer several advantages over other mucosal delivery strategies for cancer vaccines. The objective of this study is to evaluate the immune responses in mice after oral immunization with Lactobacillus (L) plantarum WCFS1 expressing a cell-wall anchored tumor antigen NY-ESO-1. And to investigate the immunostimulatory potency of this new candidate vaccine on human dendritic cells (DCs). L. plantarum displaying NY-ESO-1 induced NY-ESO-1 specific antibodies and T-cell responses in mice. By contrast, L. plantarum displaying conserved proteins such as heat shock protein-27 and galectin-1, did not induce immunity, suggesting that immune tolerance to self-proteins cannot be broken by oral administration of L. plantarum. With respect to immunomodulation, immature DCs incubated with wild type or L. plantarum-NY-ESO-1 upregulated the expression of co-stimulatory molecules and secreted a large amount of interleukin (IL)-12, TNF-α, but not IL-4. Moreover, they upregulated the expression of immunosuppressive factors such as IL-10 and indoleamine 2,3-dioxygenase. Although L. plantarum-matured DCs expressed inhibitory molecules, they stimulated allogeneic T cells in-vitro. Collectively, the data indicate that L. plantarum-NY-ESO-1 can evoke antigen-specific immunity upon oral administration and induce DC maturation, raising the potential of its use in cancer immunotherapies.

  14. Préface

    Science.gov (United States)

    Hamieh, Tayssir

    2005-05-01

    Né simultanément à Mulhouse et à Beyrouth en 1996 dans le cadre d'une collaboraiion franco-libanaise sur une initiative personnelle de Monsieur Tayssir HAMIEH. le Colloque Franco-Libanais sur la Science des Matériaux (CSM), qui s'inscrit dans le cadre des relations étroites entre la France et le Liban, est très vite devenu une occasion très importante de rencontre entre scientifiques de haut niveau, non seulement, du contour méditerranéen mais également des pays européens, américains et arabes. La quatrieme édition CSM4 est une véritable réussite grâce à la participation des chercheurs confirmés dans tous les domaines des sciences de matériaux et venant de plusieurs pays tels que la France, I'Algérie, Le Liban, la Syrie, le Maroc, la Tunisie, l'Italie, l'Espagne, le Portugal, le Royaume Uni, les États-Unis, la Russie, l'Allemagne, le Japon et I'Inde ; pour présenter plus de 350 communications orales et par affiche et couvrant presque toutes les disciplines des systèmes des matériaux. Le choix des diffèrents thèmes du colloque sur la science des matériaux a été dicté par l'importance capitale de cette discipline dans notre civilisation moderne. En fait, les matériaux utilisés pour la fabrication artisanale ou industrielle d'objets, de produits et de systèmes ainsi que pour la réalisation de constructions et d'équipements ont de tout temps défini le niveau de notre civilisation technique. La réalisation des objectifs communs de notre monde en plein développement, pour ne pas dire en pleine mutation, est en grande partie tributaire de la mise au point de nouveaux matériaux et de procédés de transformation et d'assemblages nouveaux, présentant des performances et des qualités améliorées. Le colloque a illustré et traduit, de manière remarquables, l'excellente collaboration entre chercheurs libanais et français. Le partenariat est exemplaire par la qualité des laboratoires impliqués et par le niveau scientifique des r

  15. Political PR is dying. Long live business PR! / Ilyn Oleg

    Index Scriptorium Estoniae

    Oleg, Ilyn

    2005-01-01

    Vene suurima suhtekorraldusagentuuri Imageland Public Relations rahvusvaheliste suhete juhi hinnangul on Venemaal peamisteks probleemideks PR professionaalide vähesus, nende kehv haritus oma erialal, samuti vähene teadlikkus suhtekorralduse tähtsusest äris

  16. Political PR is dying. Long live business PR! / Ilyn Oleg

    Index Scriptorium Estoniae

    Oleg, Ilyn

    2005-01-01

    Vene suurima suhtekorraldusagentuuri Imageland Public Relations rahvusvaheliste suhete juhi hinnangul on Venemaal peamisteks probleemideks PR professionaalide vähesus, nende kehv haritus oma erialal, samuti vähene teadlikkus suhtekorralduse tähtsusest äris

  17. Présentation

    Directory of Open Access Journals (Sweden)

    Marie-Hélène Zérah

    2011-11-01

    Full Text Available Ce court texte présente ce numéro spécial sur les villes indiennes et fournit des éléments de contexte pour situer les cinq contributions qui le composent. Avant d'aborder la période actuelle, un survol des politiques urbaines menées dans les décennies suivant l'indépendance souligne le rôle ambigu de la ville dans le modèle indien de développement ainsi que la relative négligence des questions urbaines jusqu'aux années 1980. Dans les années 1990, l'Inde a adopté deux réformes majeures, qui toutes deux ont eu un fort impact sur les villes : la libéralisation économique, d’une part, et la décentralisation politique via un amendement constitutionnel, d’autre part. La libéralisation économique a catalysé un processus de restructuration importante dans les métropoles, soudain perçues comme des atouts précieux pour l'implication de l'Inde dans l'économie mondiale. Cette évolution a soulevé des questions difficiles de gouvernance, notamment parce que les visions de la ville portées par les décideurs politiques prennent mal en compte la complexité des dynamiques sociales et la persistance d’un taux élevé de pauvreté ; les classes moyennes urbaines ont bénéficié plus directement de la croissance économique rapide, ce qui alimente le consumérisme et le marché immobilier. Quant à la décentralisation politique, elle n'a pas produit les résultats attendus, en partie parce que les gouvernements régionaux rechignent à accroître les capacités financières des municipalités. Une analyse critique de la mission nationale pour le renouvellement urbain (JNNURM montre que, même si cette dernière a indéniablement contribué au financement des infrastructures urbaines, elle a été beaucoup moins efficace pour ce qui est de l’amélioration de la gouvernance urbaine. Enfin, les cinq articles de ce numéro sont présentés et l’attention est attirée sur le fait que trois d’entre eux sont rédigés par

  18. Progress of NY ESO-1 in immunotherapy of hepatocellular carcinoma%NY-ESO-1在原发性肝癌免疫治疗中的研究进展

    Institute of Scientific and Technical Information of China (English)

    夏士珊; 向晓星

    2010-01-01

    NY-ESO-1抗原是CT抗原家族中的重要成员,在原发性肝癌组织中广泛表达,是迄今发现的最具免疫原性的肿瘤抗原,能在NY-ESO-1表达阳性的肝癌患者体内诱导自发性体液免疫反应和特异性T细胞免疫反应.因此,NY-ESO-1被认为是较好的肿瘤候选疫苗,在原发性肝癌免疫治疗中较具发展潜力.

  19. Expression of NY-ESO-1 in Triple-Negative Breast Cancer Is Associated with Tumor-Infiltrating Lymphocytes and a Good Prognosis.

    Science.gov (United States)

    Lee, Hee Jin; Kim, Joo Young; Song, In Hye; Park, In Ah; Yu, Jong Han; Gong, Gyungyub

    2015-01-01

    Accumulating evidence suggests that immunotherapy has great potential for treating triple-negative breast cancer (TNBC). We analyzed the expression of NY-ESO-1, which is a potent immunogenic cancer testis antigen, and its association with clinicopathological factors in large cohorts of breast cancer patients. A total of 623 consecutive breast cancer patients who underwent surgery between 1993 and 1998 and 612 TNBC patients who underwent surgery between 2004 and 2010 at Asan Medical Center were included. Immunohistochemical staining for NY-ESO-1 was performed using tissue microarrays. NY-ESO-1 was expressed in 2.6% of consecutive breast cancers, all of which were TNBC (p ESO-1 expression was identified in 9.7% of the TNBC cohort and was significantly correlated with a higher level of tumor-infiltrating lymphocytes (TIL; p = 0.026). In survival analyses, a lower level of TIL (all, p ESO-1 expression (p = 0.024) were significantly associated with poor disease-free survival. Additionally, positive NY-ESO-1 expression was an independent favorable prognostic factor in TNBC patients (p = 0.046). NY-ESO-1 is specifically expressed in TNBC, and NY-ESO-1 expression is an independent good prognostic factor in TNBC. Evaluation of NY-ESO-1 expression in TNBC might be useful for selecting patients who may benefit from vaccination therapy and also has a prognostic significance in TNBC. © 2015 S. Karger AG, Basel.

  20. ESO Phase 3 automatic data validation: groovy-based tool to assure the compliance of the reduced data with the Science Data Product Standard

    Science.gov (United States)

    Mascetti, L.; Forchı, V.; Arnaboldi, M.; Delmotte, N.; Micol, A.; Retzlaff, J.; Zampieri, S.

    2016-07-01

    The ESO Phase 3 infrastructure provides a channel to submit reduced data products for publication to the astronomical community and long-term data preservation in the ESO Science Archive Facility. To be integrated into Phase 3, data must comply to the ESO Science Data Product Standard regarding format (one unique standard data format is associated to each type of product, like image, spectrum, IFU cube, etc.) and required metadata. ESO has developed a Groovy based tool that carries out an automatic validation of the submitted reduced products that is triggered when data are uploaded and then submitted. Here we present how the tool is structured and which checks are implemented.

  1. Credibility Discourse of PR Agencies

    DEFF Research Database (Denmark)

    Isaksson, Maria; Jørgensen, Poul Erik Flyvholm

    2008-01-01

    This research examines the credibility discourse posted on the corporate websites of 60 British, Danish and Norwegian public relations agencies. The purpose was to determine the nature and patterns of the statements of credibility that PR agencies from different cultures have considered...... instrumental in establishing dependable and likeable images of their ethos. More specifically, the study seeks to establish whether there are distinct cross-cultural preferences in PR credibility discourse. Our assumption was that British and Scandinavian PR agencies assign similar relative importance...

  2. ESO Signs Largest-Ever European Industrial Contract For Ground-Based Astronomy Project ALMA

    Science.gov (United States)

    2005-12-01

    ESO, the European Organisation for Astronomical Research in the Southern Hemisphere, announced today that it has signed a contract with the consortium led by Alcatel Alenia Space and composed also of European Industrial Engineering (Italy) and MT Aerospace (Germany), to supply 25 antennas for the Atacama Large Millimeter Array (ALMA) project, along with an option for another seven antennas. The contract, worth 147 million euros, covers the design, manufacture, transport and on-site integration of the antennas. It is the largest contract ever signed in ground-based astronomy in Europe. The ALMA antennas present difficult technical challenges, since the antenna surface accuracy must be within 25 microns, the pointing accuracy within 0.6 arc seconds, and the antennas must be able to be moved between various stations on the ALMA site. This is especially remarkable since the antennas will be located outdoor in all weather conditions, without any protection. Moreover, the ALMA antennas can be pointed directly at the Sun. ALMA will have a collecting area of more than 5,600 square meters, allowing for unprecedented measurements of extremely faint objects. The signing ceremony took place on December 6, 2005 at ESO Headquarters in Garching, Germany. "This contract represents a major milestone. It allows us to move forward, together with our American and Japanese colleagues, in this very ambitious and unique project," said ESO's Director General, Dr. Catherine Cesarsky. "By building ALMA, we are giving European astronomers access to the world's leading submillimetre facility at the beginning of the next decade, thereby fulfilling Europe's desire to play a major role in this field of fundamental research." Pascale Sourisse, Chairman and CEO of Alcatel Alenia Space, said: "We would like to thank ESO for trusting us to take on this new challenge. We are bringing to the table not only our recognized expertise in antenna development, but also our long-standing experience in

  3. The Gaia-ESO Survey: metallicity of the Chamaeleon I star forming region

    CERN Document Server

    Spina, L; Palla, F; Biazzo, K; Sacco, G G; Alfaro, E J; Franciosini, E; Magrini, L; Morbidelli, L; Frasca, A; Adibekyan, V; Delgado-Mena, E; Sousa, S G; Hernandez, J I Gonzalez; Montes, D; Tabernero, H; Tautvaisiene, G; Bonito, R; Lanzafame, A C; Gilmore, G; Jeffries, R D; Vallenari, A; Bensby, T; Bragaglia, A; Flaccomio, E; Korn, A J; Pancino, E; Recio-Blanco, A; Smiljanic, R; Bergemann, M; Costado, M T; Damiani, F; Hill, V; Hourihane, A; Jofre, P; de Laverny, P; Lardo, C; Masseron, T; Prisinzano, L; Worley, C C

    2014-01-01

    Context. Recent metallicity determinations in young open clusters and star-forming regions suggest that the latter may be characterized by a slightly lower metallicity than the Sun and older clusters in the solar vicinity. However, these results are based on small statistics and inhomogeneous analyses. The Gaia-ESO Survey is observing and homogeneously analyzing large samples of stars in several young clusters and star-forming regions, hence allowing us to further investigate this issue. Aims. We present a new metallicity determination of the Chamaeleon I star-forming region, based on the products distributed in the first internal release of the Gaia-ESO Survey. Methods. 48 candidate members of Chamaeleon I have been observed with the high-resolution spectrograph UVES. We use the surface gravity, lithium line equivalent width and position in the Hertzsprung-Russell diagram to confirm the cluster members and we use the iron abundance to derive the mean metallicity of the region. Results. Out of the 48 targets,...

  4. A monolithic collapse origin for the thin/thick disc structure of ESO~243-49

    CERN Document Server

    Comerón, S; Peletier, R F; Mentz, J

    2016-01-01

    ESO 243-49 is a high-mass (circular velocity $v_{\\rm c}\\approx200\\,{\\rm km\\,s^{-1}}$) edge-on S0 galaxy in the Abell 2877 cluster at a distance of $\\sim95\\,{\\rm Mpc}$. To elucidate the origin of its thick disc, we use MUSE science verification data to study its kinematics and stellar populations. The thick disc emits $\\sim80\\%$ of the light at heights in excess of $3.5^{\\prime\\prime}$ ($1.6\\,{\\rm kpc}$). The rotation velocities of its stars lag by $30-40\\,{\\rm km\\,s^{-1}}$ compared to those in the thin disc, which is compatible with the asymmetric drift. The thick disc is found to be more metal-poor than the thin disc, but both discs have old ages. We suggest an internal origin for the thick disc stars in high-mass galaxies. We propose that the thick disc formed either ${\\rm a)}$ first in a turbulent phase with a high star formation rate and that a thin disc formed shortly afterwards, or ${\\rm b)}$ because of the dynamical heating of a thin pre-existing component. Either way, the star formation in ESO 243-49 ...

  5. Calibrating the lithium-age relation with open clusters observed with GES (Gaia-ESO Survey)

    Science.gov (United States)

    Gutiérrez Albarrán, M. L.; Montes, D.; Gómez Garrido, M.; Tabernero, H. M..; González Hernández, J. I.; GES Survey Builders

    2017-03-01

    Li depletion is strongly age-dependent but currently available data have shown a complex pattern of Li depletion on the pre- and main-sequence stars that is not yet understood. The lithium abundance observed in late-type stars depend not only of the age and the temperature but also on metallicity, mixing mechanisms, convection structure, rotation and magnetic activity. The large number of stars observed within the Gaia-ESO survey (GES - https://www.gaia-eso.eu/) for many open clusters and associations can be used to calibrate the lithium-age relation and its dependence with other parameters that can be derived from the UVES and GIRAFFE spectroscopic observations. We present here the preliminary results of the analysis of membership and Li abundance of the young clusters and associations, as well as of the intermediate-age and old open clusters, observed until now in GES (iDR4) in order to conduct a comparative study. All this information allowed us to characterize the properties of the members of these clusters and identify a series of field contaminant stars, both lithium-rich giants and non-giant outliers.

  6. Shedding light on the nature of ESO 243-49 HLX-1

    CERN Document Server

    Mapelli, M; Zampieri, L

    2013-01-01

    The point-like X-ray source HLX-1, close to the S0 galaxy ESO 243-49, is one of the strongest intermediate-mass black hole candidates. We discuss the hypothesis that ESO 243-49 is undergoing a minor merger with a gas-rich disc galaxy. We propose that the counterpart of HLX-1 coincides with the nucleus of the secondary galaxy. We re-analyze the available photometric HST data, and we compare them with the results of N-body/smoothed particle hydrodynamics simulations. In particular, we derive synthetic surface brightness profiles for the simulated counterpart of HLX-1 in six HST filters, ranging from far ultraviolet (FUV) to infrared wavelengths. Such synthetic profiles include a contribution from the stellar population associated with the simulated disrupted satellite and a contribution from an irradiated disc model. These are in agreement with the observed surface brightness profiles of the HLX-1 counterpart, provided that the merger is at sufficiently late stage (>~2.5 Gyr since the first pericentre passage)....

  7. Operational metrics for the ESO Very Large Telescope: lessons learned and future steps

    Science.gov (United States)

    Primas, F.; Marteau, S.; Tacconi-Garman, L. E.; Mainieri, V.; Mysore, S.; Rejkuba, M.; Hilker, M.; Patat, F.; Sterzik, M.; Kaufer, A.; Mieske, S.

    2016-07-01

    When ESO's Very Large Telescope opened its first dome in April 1999 it was the first ground-based facility to offer to the scientific community access to an 8-10m class telescope with both classical and queue observing. The latter was considered to be the most promising way to ensure the observing flexibility necessary to execute the most demanding scientific programmes under the required, usually very well defined, conditions. Since then new instruments have become operational and 1st generation ones replaced, filling the 12 VLT foci and feeding the VLT Interferometer and its four Auxiliary Telescopes. Operating efficiently such a broad range of instruments installed and available every night of the year on four 8-metre telescopes offers many challenges. Although it may appear that little has changed since 1999, the underlying VLT operational model has evolved in order to accommodate different requirements from the user community and features of new instruments. Did it fulfil its original goal and, if so, how well? How did it evolve? What are the lessons learned after more than 15 years of operations? A careful analysis and monitoring of statistics and trends in Phase 1 and Phase 2 has been deployed under the DOME (Dashboard for Operational Metrics at ESO) project. The main goal of DOME is to provide robust metrics that can be followed with time in a user-friendly manner. Here, we summarize the main findings on the handling of service mode observations and present the most recent developments.

  8. The Gaia-ESO Survey: the selection function of the Milky Way field stars

    Science.gov (United States)

    Stonkutė, E.; Koposov, S. E.; Howes, L. M.; Feltzing, S.; Worley, C. C.; Gilmore, G.; Ruchti, G. R.; Kordopatis, G.; Randich, S.; Zwitter, T.; Bensby, T.; Bragaglia, A.; Smiljanic, R.; Costado, M. T.; Tautvaišienė, G.; Casey, A. R.; Korn, A. J.; Lanzafame, A. C.; Pancino, E.; Franciosini, E.; Hourihane, A.; Jofré, P.; Lardo, C.; Lewis, J.; Magrini, L.; Monaco, L.; Morbidelli, L.; Sacco, G. G.; Sbordone, L.

    2016-07-01

    The Gaia-ESO Survey was designed to target all major Galactic components (i.e. bulge, thin and thick discs, halo and clusters), with the goal of constraining the chemical and dynamical evolution of the Milky Way. This paper presents the methodology and considerations that drive the selection of the targeted, allocated and successfully observed Milky Way field stars. The detailed understanding of the survey construction, specifically the influence of target selection criteria on observed Milky Way field stars is required in order to analyse and interpret the survey data correctly. We present the target selection process for the Milky Way field stars observed with Very Large Telescope/Fibre Large Array Multi Element Spectrograph and provide the weights that characterize the survey target selection. The weights can be used to account for the selection effects in the Gaia-ESO Survey data for scientific studies. We provide a couple of simple examples to highlight the necessity of including such information in studies of the stellar populations in the Milky Way.

  9. The energy source and dynamics of infrared luminous galaxy ESO 148-IG002

    CERN Document Server

    Leslie, Sarah; Kewley, Lisa; Dopita, Michael

    2014-01-01

    ESO 148-IG002 represents a transformative stage of galaxy evolution, containing two galaxies at close separation which are currently coalescing into a single galaxy. We present integral field data of this galaxy from the ANU Wide Field Spectrograph (WiFeS). We analyse our integral field data using optical line ratio maps and velocity maps. We apply active galactic nucleus (AGN), star-burst and shock models to investigate the relative contribution from star-formation, shock excitation and AGN activity to the optical emission in this key merger stage. We find that ESO 148-IG002 has a flat metallicity gradient, consistent with a recent gas inflow. We separate the line emission maps into a star forming region with low velocity dispersion that spatially covers the whole system as well as a southern high velocity dispersion region with a coherent velocity pattern which could either be rotation or an AGN-driven outflow, showing little evidence for pure star formation. We show that the two overlapping galaxies can be...

  10. Electroactive Shape Memory Property of a Cu-decorated CNT Dispersed PLA/ESO Nanocomposite

    Directory of Open Access Journals (Sweden)

    Javed Alam

    2015-09-01

    Full Text Available Shape memory polymer (SMP nanocomposites with a fast electro-actuation speed were prepared by dispersing Cu-decorated carbon nanotubes (CNTs (Cu-CNTs, 1 wt %, 2 wt %, and 3 wt % in a polylactic acid (PLA/epoxidized soybean oil (ESO blend matrix. The shape memory effect (SME induced by an electrical current was investigated by a fold-deploy “U”-shape bending test. In addition, the Cu-CNT dispersed PLA/ESO nanocomposite was characterized by atomic force microscopy (AFM, dynamic mechanical analysis (DMA and tensile and electrical measurements. The results demonstrated that the SME was dependent on the Cu-CNT content in the nanocomposites. When comparing the SMEs of the nanocomposite specimens with different Cu-CNT contents, the 2 wt % Cu-CNT dispersed system exhibited a shape recovery as high as 98% within 35 s due to its higher electrical conductivity that results from uniform Cu-CNT dispersion. However, the nanocomposites that contained 1 wt % and 3 wt % Cu-CNTs required 75 s and 63 s, respectively, to reach a maximum recovery level. In addition, the specimens exhibited better mechanical properties after the addition of Cu-CNTs.

  11. The Gaia-ESO Survey: Metal-rich Bananas in the Bulge

    Science.gov (United States)

    Williams, Angus A.; Evans, N. W.; Molloy, Matthew; Kordopatis, Georges; Smith, M. C.; Shen, J.; Gilmore, G.; Randich, S.; Bensby, T.; Francois, P.; Koposov, S. E.; Recio-Blanco, A.; Bayo, A.; Carraro, G.; Casey, A.; Costado, T.; Franciosini, E.; Hourihane, A.; de Laverny, P.; Lewis, J.; Lind, K.; Magrini, L.; Monaco, L.; Morbidelli, L.; Sacco, G. G.; Worley, C.; Zaggia, S.; Mikolaitis, Š.

    2016-06-01

    We analyze the kinematics of ˜2000 giant stars in the direction of the Galactic bulge, extracted from the Gaia-ESO survey in the region -10^\\circ ≲ {\\ell }≲ 10^\\circ and -11^\\circ ≲ b≲ -3^\\circ . We find distinct kinematic trends in the metal-rich ([{{M}}/{{H}}]\\gt 0) and metal-poor ([{{M}}/{{H}}]\\lt 0) stars in the data. The velocity dispersion of the metal-rich stars drops steeply with latitude, compared to a flat profile in the metal-poor stars, as has been seen previously. We argue that the metal-rich stars in this region are mostly on orbits that support the boxy-peanut shape of the bulge, which naturally explains the drop in their velocity dispersion profile with latitude. The metal-rich stars also exhibit peaky features in their line of sight velocity histograms, particularly along the minor axis of the bulge. We propose that these features are due to stars on resonant orbits supporting the boxy-peanut bulge. This conjecture is strengthened through the comparison of the minor axis data with the velocity histograms of resonant orbits generated in simulations of buckled bars. The “banana” or 2:1:2 orbits provide strongly bimodal histograms with narrow velocity peaks that resemble the Gaia-ESO metal-rich data.

  12. VizieR Online Data Catalog: Surface Photometry of ESO-Uppsala Galaxies (Lauberts+ 1989)

    Science.gov (United States)

    Lauberts, A.; Valentijn, E. A.

    2006-04-01

    The 15467 southern galaxies in this catalog were scanned from 407 blue and 407 red original ESO-Schmidt plates using a PDS microdensitometer. The galaxies were selected from the ESO-Uppsala Catalogue (VII/34). The original selection criterion was a minimum visual angular diameter of 1arcmin. The plates were calibrated using a catalog of photo- electric standards of 1700 standard galaxies transformed to a photometric standard system (Cousins) created by the authors. The result is a catalog acquired in a homogeneous fashion for all types of galaxies in various environments. The extracted parameters include radial surface brightness profiles, magnitudes at several isophotal levels, colors, color gradients, effective radius parameters, structural parameters such as axial ratios, position angles, and profile gradients. The full version of the catalog, made of 190 columns, is available as the file "esolv.fit" in FITS table format. The ascii file "esolv1.dat" contains a subset of these columns which includes those parameters listed in the printed book version. Detailed discussion of the catalog creation is given in the published book version (ISBN 3-923524-31-5) (2 data files).

  13. VLT/X-shooter observations of blue compact galaxies Haro 11 and ESO 338-IG 004

    CERN Document Server

    Guseva, N G; Fricke, K J; Henkel, C

    2012-01-01

    (abridged) Strongly star-forming galaxies of subsolar metallicities are typical of the high-redshift universe. Here we therefore provide accurate data for two low-z analogs, the well-known low-metallicity emission-line galaxies Haro 11 and ESO 338-IG 004. On the basis of Very Large Telescope/X-shooter spectroscopic observations in the wavelength range 3000-24000\\AA, we use standard direct methods to derive physical conditions and element abundances. Furthermore, we use X-shooter data together with Spitzer observations in the mid-infrared range to attempt to find hidden star formation. We derive interstellar oxygen abundances of 12 + log O/H = 8.33+/-0.01, 8.10+/-0.04, and 7.89+/-0.01 in the two HII regions B and C of Haro 11 and in ESO 338-IG 004, respectively. The observed fluxes of the hydrogen lines correspond to the theoretical recombination values after correction for extinction with a single value of the extinction coefficient C(Hbeta) across the entire wavelength range from the near-ultraviolet to the ...

  14. ADOLESCENCIA, TIEMPO LIBRE Y EDUCACIÓN. UN ESTUDIO CON ALUMNOS DE LA ESO

    Directory of Open Access Journals (Sweden)

    José Manuel Muñoz Rodríguez

    2010-01-01

    Full Text Available Presentamos el resultado de una investigación cuyo objetivo ha sido analizar la distribución, usos y valores que sostienen el tiempo libre de los estudiantes de Educación Secundaria Obligatoria (ESO de Salamanca. El instrumento de recogida de datos ha sido la encuesta; el muestreo aleatorio simple de unidades por conglomerados, dispuesto por centros escolares y estratos, según localización geográfica (rural, urbana y pertenencia al sector público o privado. El análisis se efectuó a partir de tres variables: el nivel de estudios (1º, 2º, 3º y 4º ESO, el género, y la ubicación geográfica, si bien el trabajo se centra en la primera de ellas. Los resultados muestran escasez de valores educativos en su tiempo libre y diferencias significativas a tener en cuenta en función del nivel educativo. El tiempo libre es un tiempo crucial en la vida de los adolescentes y presenta procesos análogos a los experimentados en el tiempo escolar.

  15. The Gaia-ESO Survey: Properties of the intermediate age open cluster NGC 4815

    CERN Document Server

    Friel, E D; Bragaglia, A; Jacobson, H R; Magrini, L; Prisinzano, L; Randich, S; Tosi, M; Cantat-Gaudin, T; Vallenari, A; Smiljanic, R; Carraro, G; Sordo, R; Maiorca, E; Tautvaisviene, G; Sestito, P; Zaggia, S; Jimenez-Esteban, F M; Gilmore, G; Jeffries, R D; Alfaro, E; Bensby, T; Koposov, S E; Korn, A J; Pancino, E; Recio-Blanco, A; Franciosini, E; Hill, V; Jackson, R J; de Laverny, P; Morbidelli, L; Sacco, G G; Worley, C C; Hourihane, A; Costado, M T; Jofre, P; Lind, K

    2014-01-01

    NGC 4815 is a populous ~500 Myr open cluster at a Galactocentric radius of 7 kpc observed in the first six months of the Gaia-ESO Survey. Located in the inner Galactic disk, NGC 4815 is an important tracer of the abundance gradient, where few intermediate age open clusters are found. We use the survey derived radial velocities, stellar atmospheric parameters, metallicity, and elemental abundances for stars targeted as potential members of this cluster to carry out an analysis of cluster properties. The radial velocity distribution of stars in the cluster field is used to define the cluster systemic velocity and derive likely cluster membership for stars observed by the Gaia-ESO Survey. We investigate the distributions of Fe and Fe-peak elements, alpha-elements, and the light elements Na and Al and characterize the cluster's internal chemical homogeneity comparing it to the properties of radial velocity non-member stars. Utilizing these cluster properties, the cluster color-magnitude diagram is analyzed and th...

  16. EDisCS -- the ESO Distant Cluster Survey -- Sample Definition and Optical Photometry

    CERN Document Server

    White, S D M; Simard, L; Rudnick, G; De Lucia, G; Aragón-Salamanca, A; Bender, R; Best, P; Bremer, M; Charlot, S; Dalcanton, J; Dantel, M; Desai, V; Fort, B; Halliday, C; Jablonka, P; Kauffmann, G; Mellier, Y; Milvang-Jensen, B; Pellò, R; Poggianti, B M; Poirier, S; Rottgering, H; Saglia, R; Schneider, P; Zaritsky, D

    2005-01-01

    We present the ESO Distant Cluster Survey (EDisCS) a survey of 20 fields containing distant galaxy clusters with redshifts ranging from 0.4 to almost 1.0. Candidate clusters were chosen from among the brightest objects identified in the Las Campanas Distant Cluster Survey, half with estimated redshift z_est~0.5 and half with z_est~0.8. They were confirmed by identifying red sequences in moderately deep two colour data from VLT/FORS2. For confirmed candidates we have assembled deep three-band optical photometry using VLT/FORS2, deep near-infrared photometry in one or two bands using NTT/SOFI, deep optical spectroscopy using VLT/FORS2, wide field imaging in two or three bands using the ESO Wide Field Imager, and HST/ACS mosaic images for 10 of the most distant clusters. This first paper presents our sample and the VLT photometry we have obtained. We present images, colour-magnitude diagrams and richness estimates for our clusters, as well as giving redshifts and positions for the brightest cluster members. Subs...

  17. The Gaia-ESO Survey: the selection function of the Milky Way field stars

    CERN Document Server

    Stonkute, E; Howes, L M; Feltzing, S; Worley, C C; Gilmore, G; Ruchti, G R; Kordopatis, G; Randich, S; Zwitter, T; Bensby, T; Bragaglia, A; Smiljanic, R; Costado, M T; Tautvaisiene, G; Casey, A R; Korn, A J; Lanzafame, A C; Pancino, E; Franciosini, E; Hourihane, A; Jofre, P; Lardo, C; Lewis, J; Magrini, L; Monaco, L; Morbidelli, L; Sacco, G G; Sbordone, L

    2016-01-01

    The Gaia-ESO Survey was designed to target all major Galactic components (i.e., bulge, thin and thick discs, halo and clusters), with the goal of constraining the chemical and dynamical evolution of the Milky Way. This paper presents the methodology and considerations that drive the selection of the targeted, allocated and successfully observed Milky Way field stars. The detailed understanding of the survey construction, specifically the influence of target selection criteria on observed Milky Way field stars is required in order to analyse and interpret the survey data correctly. We present the target selection process for the Milky Way field stars observed with VLT/FLAMES and provide the weights that characterise the survey target selection. The weights can be used to account for the selection effects in the Gaia-ESO Survey data for scientific studies. We provide a couple of simple examples to highlight the necessity of including such information in studies of the stellar populations in the Milky Way.

  18. N° 15-2000: ESA, CERN and ESO launch "Physics on Stage"

    Science.gov (United States)

    2000-03-01

    But how much do the citizens of Europe really know about physics? Here is a unique opportunity to learn more about this elusive subject! Beginning in February 2000, three major European research establishments [1] are organising a unique Europe-wide programme to raise the public awareness of physics and related sciences. "Physics on Stage" is launched by the European Space Agency (ESA), the European Laboratory for Particle Physics (CERN), and the European Southern Observatory (ESO), with support from the European Union (EU). Other partners include the European Physical Society (EPS) and the European Association for Astronomy Education (EAAE). This exciting programme is part of the European Week for Science and Technology and will culminate in a Science Festival during November 6-11, 2000, at CERN, Geneva. Why "Physics on Stage"? The primary goal of "Physics on Stage" is to counteract the current decline in interest and knowledge of physics among Europe's citizens by means of a series of highly visible promotional activities. It will bring together leading scientists and educators, government bodies and the media, to confront the diminishing attraction of physics to young people and to develop strategies to reverse this trend. The objective in the short term is to infuse excitement and to provide new educational materials. In the longer term, "Physics on Stage" will generate new developments by enabling experts throughout Europe to meet, exchange and innovate. "Physics on Stage" in 22 European Countries. "Physics on Stage" has been initiated in 22 European countries [2]. In each country, a dedicated National Steering Committee (NSC) is being formed which will be responsible for their own national programme. A list of contact addresses is attached below. "Physics on Stage" is based on a series of high-profile physics-related activities that will inform the European public in general, and European high school physics teachers and media representatives in particular

  19. The Gaia-ESO Survey: Exploring the complex nature and origins of the Galactic bulge populations

    Science.gov (United States)

    Rojas-Arriagada, A.; Recio-Blanco, A.; de Laverny, P.; Mikolaitis, Š.; Matteucci, F.; Spitoni, E.; Schultheis, M.; Hayden, M.; Hill, V.; Zoccali, M.; Minniti, D.; Gonzalez, O. A.; Gilmore, G.; Randich, S.; Feltzing, S.; Alfaro, E. J.; Babusiaux, C.; Bensby, T.; Bragaglia, A.; Flaccomio, E.; Koposov, S. E.; Pancino, E.; Bayo, A.; Carraro, G.; Casey, A. R.; Costado, M. T.; Damiani, F.; Donati, P.; Franciosini, E.; Hourihane, A.; Jofré, P.; Lardo, C.; Lewis, J.; Lind, K.; Magrini, L.; Morbidelli, L.; Sacco, G. G.; Worley, C. C.; Zaggia, S.

    2017-05-01

    Context. As observational evidence steadily accumulates, the nature of the Galactic bulge has proven to be rather complex: the structural, kinematic, and chemical analyses often lead to contradictory conclusions. The nature of the metal-rich bulge - and especially of the metal-poor bulge - and their relation with other Galactic components, still need to be firmly defined on the basis of statistically significant high-quality data samples. Aims: We used the fourth internal data release of the Gaia-ESO survey to characterize the bulge metallicity distribution function (MDF), magnesium abundance, spatial distribution, and correlation of these properties with kinematics. Moreover, the homogeneous sampling of the different Galactic populations provided by the Gaia-ESO survey allowed us to perform a comparison between the bulge, thin disk, and thick disk sequences in the [Mg/Fe] vs. [Fe/H] plane in order to constrain the extent of their eventual chemical similarities. Methods: We obtained spectroscopic data for 2500 red clump stars in 11 bulge fields, sampling the area -10° ≤ l ≤ + 8° and -10° ≤ b ≤ -4° from the fourth internal data release of the Gaia-ESO survey. A sample of 6300 disk stars was also selected for comparison. Spectrophotometric distances computed via isochrone fitting allowed us to define a sample of stars likely located in the bulge region. Results: From a Gaussian mixture models (GMM) analysis, the bulge MDF is confirmed to be bimodal across the whole sampled area. The relative ratio between the two modes of the MDF changes as a function of b, with metal-poor stars dominating at high latitudes. The metal-rich stars exhibit bar-like kinematics and display a bimodality in their magnitude distribution, a feature which is tightly associated with the X-shape bulge. They overlap with the metal-rich end of the thin disk sequence in the [Mg/Fe] vs. [Fe/H] plane. On the other hand, metal-poor bulge stars have a more isotropic hot kinematics and do

  20. Expression of NY-ESO-1 Gene in Human Bladder Cancer%NY-ESO-1基因在膀胱癌中的表达及临床意义的研究

    Institute of Scientific and Technical Information of China (English)

    王慕文; 毕东滨; 金讯波; 马庆铮

    2010-01-01

    目的 探讨NY-ESO-1的表达与膀胱癌分期分级的关系以及临床意义.方法 回顾性研究2001~2002年膀胱癌组织32例,其中男性24例,女性8例.正常膀胱粘膜对照取自耻骨上经膀胱前列腺切除术的良性前列腺增生的患者.阳性对照为正常睾丸组织.常规行RT-PCR方法检测膀胱癌组织及对照组等NY-ESO-1基因的表达,分析其表达与膀胱癌分期分级的关系以及临床意义.结果 NY-ESO-1 mRNA在32例膀胱癌组织中12例表达(37.5%),在正常膀胱粘膜上没有表达.肿瘤组织中PCR反应的产物与正常睾丸的表达产物一致.NY-ESO-1 mRNA的表达和膀胱癌的病理分级相关,有统计学差异(P<0.05).NY-ESO-1 mRNA的表达率随着肿瘤病理分级的增高而升高:G1期是0/3(0%);G2期是4/16(25%);G3期是8/13(61.54%).浸润性膀胱癌中NY-ESO-1 mRNA的表达与表浅性肿瘤的表达无显著性差异.结论 NY-ESO-1 mRNA在正常膀胱组织上没有表达,仅在正常睾丸组织和病理膀胱癌组织上有表达.NY-ESO-1 mRNA的表达率随着膀胱癌病理分级的增高而升高.

  1. Présentation

    Directory of Open Access Journals (Sweden)

    Gregor Perko

    2011-12-01

    Full Text Available Au cours des dernières décennies où l’on assiste à une refondation de la morphologie, la discipline s’intéresse de plus en plus à des phénomènes « périphériques », « marginaux », « irréguliers » ou « extragrammaticaux », à des phénomènes n’appartenant pas aux « régions nodales » de la morphologie. Le présent numéro de Linguistica, premier numéro thématique de notre revue, réunit des études qui s’intéres- sent aux frontières internes et externes de la morphologie. La diversité et la richesse des thèmes abordés et des approches proposées témoignent d’un intérêt croissant que les linguistes, non pas uniquement les morphologues, portent à cette thématique. Les articles proposés s’articulent autour de cinq axes majeurs. Un premier axe rassemble les articles qui étudient les frontières entre différentes composantes de la morphologie. L’étude de Michel Roché examine les contraintes lexicales et morphophonologiques sur le paradigme des dérivés en –aie. Les résultats de son analyse remettent en question la notion de « règle de construction des lexèmes ». Irena Stramljič Breznik et Ines Voršič se penchent sur les néologismes de sport en slovène et essaient d’évaluer la productivité ou la créativité des procédés morphologiques en jeu. Dans une étude d’inspiration cognitiviste, Alexandra Bagasheva aborde l’hétérogénéité des verbes composés en anglais. En s’appuyant sur les données fournies par les para- digmes verbaux du maltais, Maris Camilleri examine la complexité du phénomène de classes flexionnelles basées sur les radicaux. Trois travaux concernent des procédés typiquement « extragrammaticaux » servant à former le plus souvent des occasionnalismes: Arnaud Léturgie tente de dégager des propriétés prototypiques de l’amalgamation lexicale en français, notamment celles de la création des mots-valises; Silvia Cacchiani analyse, à l

  2. ESO Astronomers Detect a Galaxy at the Edge of the Universe

    Science.gov (United States)

    1995-09-01

    Starlight from the Depths of Time Four European astronomers [1] have taken advantage of the superb imaging quality of the ESO 3.5-metre New Technology Telescope (NTT) at the La Silla observatory, to detect a galaxy at an extremely large distance. They conclude that its redshift [2] is z = 4.4; thus, this galaxy is by far the most remote ever detected. In fact, it has taken its light about 90 percent of the age of the Universe to reach us, and we now observe this early object as it appeared, only 1 - 2 billion years [3] after the Universe was created in the Big Bang. Still, the galaxy contains a considerable amount of elements that must have been produced in stars. This proves that stars were formed in normal galaxies, already before this very early epoch. Galaxies in the Very Early Universe Astronomical observations during the past decade indicate that the age of the Universe is probably somewhere between 13 and 17 billion years. It is expected that further studies at the limit of available telescopes during the next years will make it possible to determine this fundamental parameter more accurately. But whatever the actual age, one of the central questions which must answered in order to understand the evolution of the Universe is the time of formation of the first stars and galaxies; its determination is accordingly a prime goal of current cosmological observations. This early process was crucial for the distribution of matter now observed, but how long after the Big Bang did it actually happen? We do not know yet. In order to cast more light on this important question, we must look back to this very early epoch by detecting and measuring objects at the largest possible distances, i.e. at the highest redshifts. However, this is extremely difficult because of the faintness of such objects and so far, progress in this fundamental research field has been slow. An Enriched Hydrogen Cloud at z = 4.4 In 1994, the ESO team obtained a high-resolution, detailed spectrum

  3. Expression of NY-ESO-1 and LAGE-1 cancer-testis antigens in hepatocellular carcinoma%NY-ESO-1和LAGE-1癌症-睾丸抗原在肝细胞癌的表达

    Institute of Scientific and Technical Information of China (English)

    张文敏; 肖刚; 张萌; 郭爱林; 董愉; 文剑明

    2005-01-01

    目的检测NY-ESO-1和LAGE-1癌症-睾丸抗原在肝细胞癌中的表达,探讨其作为肝细胞癌免疫治疗靶标的可行性及其与肝癌生物学行为的关系.方法逆转录-聚合酶链反应(RT-PCR)和免疫组织化学EnVision二步法检测30例肝细胞癌新鲜标本NY-ESO-1和LAGE-1的表达;另将191例肝癌石蜡组织制成芯片观察NY-ESO-1蛋白在肝癌中的分布和表达.结果NY-ESO-1和LAGE-1基因mRNA在肝癌中的阳性表达率分别是33.3%(10/30)和16.7%(5/30),至少表达1种基因mRNA者为36.7%(11/30);NY-ESO-1蛋白主要分布在肝癌细胞胞质,有效标本中NY-ESO-1表达13.8%(24/174),小肝癌、中晚期肝癌、发生转移肝癌中的阳性表达率逐渐升高,分别为6.8%(3/44)、16.2%(21/130)、23.1%(12/52),不发生转移的肝癌仅为9.8%(12/122),其中转移组与无转移组之间比较差异有统计学意义(P<0.05),全部病例癌组织与癌旁组织比较差异有统计学意义(P<0.01).NY-ESO-1蛋白的阳性表达与肿瘤大小无关,所有癌旁肝组织均未见NY-ESO-1和LAGE-1的mRNA和蛋白的表达.结论 NY-ESO-1/LAGE-1在肝细胞癌组织中的特异性表达提示其可作为肝细胞癌特异性免疫治疗潜在的靶标;NY-ESO-1在肝癌早期出现,随病情进展表达率逐步增高,转移患者最高,提示NY-ESO-1肽疫苗可能作为晚期肝癌患者治疗手段之一.

  4. Resiquimod as an immunologic adjuvant for NY-ESO-1 protein vaccination in patients with high-risk melanoma.

    Science.gov (United States)

    Sabado, Rachel Lubong; Pavlick, Anna; Gnjatic, Sacha; Cruz, Crystal M; Vengco, Isabelita; Hasan, Farah; Spadaccia, Meredith; Darvishian, Farbod; Chiriboga, Luis; Holman, Rose Marie; Escalon, Juliet; Muren, Caroline; Escano, Crystal; Yepes, Ethel; Sharpe, Dunbar; Vasilakos, John P; Rolnitzsky, Linda; Goldberg, Judith D; Mandeli, John; Adams, Sylvia; Jungbluth, Achim; Pan, Linda; Venhaus, Ralph; Ott, Patrick A; Bhardwaj, Nina

    2015-03-01

    The Toll-like receptor (TLR) 7/8 agonist resiquimod has been used as an immune adjuvant in cancer vaccines. We evaluated the safety and immunogenicity of the cancer testis antigen NY-ESO-1 given in combination with Montanide (Seppic) with or without resiquimod in patients with high-risk melanoma. In part I of the study, patients received 100 μg of full-length NY-ESO-1 protein emulsified in 1.25 mL of Montanide (day 1) followed by topical application of 1,000 mg of 0.2% resiquimod gel on days 1 and 3 (cohort 1) versus days 1, 3, and 5 (cohort 2) of a 21-day cycle. In part II, patients were randomized to receive 100-μg NY-ESO-1 protein plus Montanide (day 1) followed by topical application of placebo gel [(arm A; n = 8) or 1,000 mg of 0.2% resiquimod gel (arm B; n = 12)] using the dosing regimen established in part I. The vaccine regimens were generally well tolerated. NY-ESO-1-specific humoral responses were induced or boosted in all patients, many of whom had high titer antibodies. In part II, 16 of 20 patients in both arms had NY-ESO-1-specific CD4⁺ T-cell responses. CD8⁺ T-cell responses were only seen in 3 of 12 patients in arm B. Patients with TLR7 SNP rs179008 had a greater likelihood of developing NY-ESO-1-specific CD8⁺ responses. In conclusion, NY-ESO-1 protein in combination with Montanide with or without topical resiquimod is safe and induces both antibody and CD4⁺ T-cell responses in the majority of patients; the small proportion of CD8⁺ T-cell responses suggests that the addition of topical resiquimod to Montanide is not sufficient to induce consistent NY-ESO-1-specific CD8⁺ T-cell responses.

  5. CalVin 3 — A New Release of the ESO Calibrator Selection Tool for the VLT Interferometer

    Science.gov (United States)

    Wittkowski, M.; Ballester, P.; Bonneau, D.; Chelli, A.; Chesneau, O.; Cruzalèbes, P.; Duvert, G.; Hummel, C.; Lafrasse, S.; Mella, G.; Melnick, J.; Mérand, A.; Mourard, D.; Percheron, I.; Sacuto, S.; Shabun, K.; Stefl, S.; Vinther, J.

    2011-09-01

    Interferometric observations require frequent measurements of calibration stars of known diameter to estimate the instrumental transfer function. ESO offers the preparation tool CalVin to select suitable calibrators from an underlying list of calibrators. The latest version 3, first released in January 2011, offers major improvements in the number of available calibrators, the functionality of the search tool, as well as in terms of performance and ease of use. It has been developed in a collaboration between ESO and the French Jean-Marie Mariotti Center (JMMC).

  6. Análisis de recursos digitales de Matemáticas para el primer ciclo de la ESO

    OpenAIRE

    Fraile-Bravo, María

    2012-01-01

    Este trabajo tiene la intención de crear un lugar dónde se recopilen recursos didácticos de matemáticas para el primer ciclo de la ESO, por el momento, con el propósito de seleccionar y recomendar los más adecuados para cada unidad o tema que se trabaja en esos dos cursos escolares. Existen muchas páginas en la red que contienen catálogos de recursos educativos, quizás demasiadas. Lo que este proyecto intenta aportar es que los recursos didácticos se presenten clasificados segú...

  7. Evaluation of LAGE-1 and NY-ESO-1 expression in multiple myeloma patients to explore possible benefits of their homology for immunotherapy.

    Science.gov (United States)

    de Carvalho, Fabricio; Vettore, Andre L; Inaoka, Riguel J; Karia, Bruno; Andrade, Valéria C C; Gnjatic, Sacha; Jungbluth, Achim A; Colleoni, Gisele W B

    2011-01-20

    Due to the high homology between the LAGE-1 and NY-ESO-1 proteins, we hypothesized that an anti-NY-ESO-1 vaccine might elicit LAGE-1 immunity and hence may be effective in multiple myeloma (MM) patients with LAGE-1-positive/NY-ESO-1-negative tumors. Therefore, we set out to evaluate LAGE-1 and NY-ESO-1 mRNA and protein expression in MM patients in a bid to evaluate possible benefits of their homology for immunotherapy. LAGE-1 (a and b isoforms) and NY-ESO-1 mRNA expression was studied in 18 normal tissues and 50 bone marrow MM samples by RT-PCR. LAGE-1 and NY-ESO-1 protein expression was analyzed by immunohistochemistry (IHC) in 27 MM specimens using mAbs 219-510-23 and E978. Spontaneous serological immune response against both antigens was analyzed by ELISA in sera from 33 MM patients. LAGE-1 (a and b isoforms) was positive in 42% and NY-ESO-1 in 26% of the MM samples analyzed by RT-PCR. Both genes were found to be expressed in 18% of the cases, while at least one of the genes was found to be expressed in 50% of the cases. In LAGE-1 positive samples, 81% were positive for LAGE-1a and 19% were positive for both LAGE-1a and -1b. LAGE-1 and NY-ESO-1 protein expression could only be detected in two cases by IHC and there was a clear strong spontaneous antibody response to LAGE-1 and NY-ESO-1 in only one MM patient. In conclusion, LAGE-1a and NY-ESO-1 homology cannot be easily exploited in an anti-NY-ESO-1 vaccine given the low frequency of protein expression detected by IHC or serum analysis.

  8. Measurement of serum antibodies against NY-ESO-1 by ELISA: A guide for the treatment of specific immunotherapy for patients with advanced colorectal cancer.

    Science.gov (United States)

    Long, Yan-Yan; Wang, Yu; Huang, Qian-Rong; Zheng, Guang-Shun; Jiao, Shun-Chang

    2014-10-01

    NY-ESO-1 has been identified as one of the most immunogenic antigens; thus, is a highly attractive target for cancer immunotherapy. The present study analyzed the expression of serum antibodies (Abs) against NY-ESO-1 in patients with advanced colorectal cancer (CRC), with the aim of guiding the treatment of NY-ESO-1-based specific-immunotherapy for these patients. Furthermore, the present study was the first to evaluate the kinetic expression of anti-NY-ESO-1 Abs and investigate the possible influencing factors. A total of 239 serum samples from 155 pathologically confirmed patients with advanced CRC (stages III and IV) were collected. The presence of spontaneous Abs against NY-ESO-1 was analyzed using an enzyme-linked immunosorbent assay (ELISA). The results demonstrated that 24.5% (38/155) of the investigated patients were positive for NY-ESO-1-specific Abs. No statistically significant correlations were identified between the expression of anti-NY-ESO-1 Abs and clinicopathological parameters, including age and gender, location, grading, local infiltration, lymph node status, metastatic status and K-ras mutation status (P>0.05). In 59 patients, the kinetic expression of anti-NY-ESO-1 Abs was analyzed, of which 14 patients were initially positive and 45 patients were initially negative. Notably, 16/59 (27.1%) patients changed their expression status during the study period, and the initially positive patients were more likely to change compared with the initially negative patients (85.7 vs. 8.8%; PESO-1 by ELISA is an easy and feasible method. The high expression rate of NY-ESO-1-specific Abs in CRC patients indicates that measuring the levels of serum Abs against NY-ESO-1 may guide the treatment of NY-ESO-1-based specific immunotherapy for patients with advanced CRC.

  9. Integrated NY-ESO-1 antibody and CD8+ T-cell responses correlate with clinical benefit in advanced melanoma patients treated with ipilimumab.

    Science.gov (United States)

    Yuan, Jianda; Adamow, Matthew; Ginsberg, Brian A; Rasalan, Teresa S; Ritter, Erika; Gallardo, Humilidad F; Xu, Yinyan; Pogoriler, Evelina; Terzulli, Stephanie L; Kuk, Deborah; Panageas, Katherine S; Ritter, Gerd; Sznol, Mario; Halaban, Ruth; Jungbluth, Achim A; Allison, James P; Old, Lloyd J; Wolchok, Jedd D; Gnjatic, Sacha

    2011-10-04

    Ipilimumab, a monoclonal antibody against cytotoxic T lymphocyte antigen 4 (CTLA-4), has been shown to improve survival in patients with advanced metastatic melanoma. It also enhances immunity to NY-ESO-1, a cancer/testis antigen expressed in a subset of patients with melanoma. To characterize the association between immune response and clinical outcome, we first analyzed NY-ESO-1 serum antibody by ELISA in 144 ipilimumab-treated patients with melanoma and found 22 of 140 (16%) seropositive at baseline and 31 of 144 (22%) seropositive following treatment. These NY-ESO-1-seropositive patients had a greater likelihood of experiencing clinical benefit 24 wk after ipilimumab treatment than NY-ESO-1-seronegative patients (P = 0.02, relative risk = 1.8, two-tailed Fisher test). To understand why some patients with NY-ESO-1 antibody failed to experience clinical benefit, we analyzed NY-ESO-1-specific CD4(+) and CD8(+) T-cell responses by intracellular multicytokine staining in 20 NY-ESO-1-seropositive patients and found a surprising dissociation between NY-ESO-1 antibody and CD8 responses in some patients. NY-ESO-1-seropositive patients with associated CD8(+) T cells experienced more frequent clinical benefit (10 of 13; 77%) than those with undetectable CD8(+) T-cell response (one of seven; 14%; P = 0.02; relative risk = 5.4, two-tailed Fisher test), as well as a significant survival advantage (P = 0.01; hazard ratio = 0.2, time-dependent Cox model). Together, our data suggest that integrated NY-ESO-1 immune responses may have predictive value for ipilimumab treatment and argue for prospective studies in patients with established NY-ESO-1 immunity. The current findings provide a strong rationale for the clinical use of modulators of immunosuppression with concurrent approaches to favor tumor antigen-specific immune responses, such as vaccines or adoptive transfer, in patients with cancer.

  10. Préface

    Science.gov (United States)

    Paulus, Werner; Meinnel, Jean

    2003-02-01

    de vue européen, si les sources de l'ILL et d'ISIS peuvent encore être considérées comme des leaders au point de vue mondial, il est évidemment souhaitable que la nouvelle source neutronique à spallation (European Spallation Source : ESS) soit rapidement réalisée. Aujourd'hui ce projet est bien avancé, cette source devrait dépasser le flux des sources actuelles par près de deux ordres de grandeur et ainsi de maintenir au meilleur niveau les compétences Européennes. Il est évident qu'une utilisation efficace et intelligente des sources existantes, mais aussi de celles de la nouvelle génération, implique une certaine infrastructure nationale tant au niveau de la conception, de la réalisation que du fonctionnement des différents spectromètres. Ceci implique un très fort engagement des universités dans les différents projets de recherche. Le devoir des universités qui en résulte est donc d'intégrer l'utilisation des “grands instruments" dans leur programme d'enseignement. Dans ce sens, nous souhaitons que ce cours, entièrement rédigé en français, contribue à la fois à aider les chercheurs “non spécialistes” à accéder plus facilement au domaine neutronique, mais aussi à servir de base aux enseignants pour l'organisation et la préparation de leurs cours.Nous tenons à remercier tous les collègues qui ont accepté de rédiger de façon détaillée les cours qu'ils avaient présentés oralement dans la grande salle du VVF de Trégastel, ainsi que toutes les personnes qui ont contribué à la réussite du séjour ou à la réalisation de ce fascicule. Nous gardons un excellent souvenir de l'atmosphère de l'École qui a eu lieu à Trégastel, en plein centre de la côte de granite rose en Bretagne, en mai 2001 et était jumelée avec les Journées de la diffusion neutronique, elles aussi organisées sous l'égide de la SFN.Nous souhaitons que la lecture de cet ouvrage soit utile à un maximum de chercheurs.

  11. Vaccination with a recombinant protein encoding the tumor-specific antigen NY-ESO-1 elicits an A2/157-165-specific CTL repertoire structurally distinct and of reduced tumor reactivity than that elicited by spontaneous immune responses to NY-ESO-1-expressing Tumors.

    Science.gov (United States)

    Bioley, Gilles; Guillaume, Philippe; Luescher, Immanuel; Bhardwaj, Nina; Mears, Gregory; Old, Lloyd; Valmori, Danila; Ayyoub, Maha

    2009-01-01

    In a recent vaccination trial assessing the immunogenicity of an NY-ESO-1 (ESO) recombinant protein administered with Montanide and CpG, we have obtained evidence that this vaccine induces specific cytolytic T lymphocytes (CTL) in half of the patients. Most vaccine-induced CTLs were directed against epitopes located in the central part of the protein, between amino acids 81 and 110. This immunodominant region, however, is distinct from another ESO CTL region, 157-165, that is a frequent target of spontaneous CTL responses in A2+ patients bearing ESO tumors. In this study, we have investigated the CTL responses to ESO 157-165 in A2+ patients vaccinated with the recombinant protein. Our data indicate that after vaccination with the protein, CTL responses to ESO 157-165 are induced in some, but not all, A2+ patients. ESO 157-165-specific CTLs induced by vaccination with the ESO protein were functionally heterogeneous in terms of tumor recognition and often displayed decreased tumor reactivity as compared with ESO 157-165-specific CTLs isolated from patients with spontaneous immune responses to ESO. Remarkably, protein-induced CTLs used T-cell receptors similar to those previously isolated from patients vaccinated with synthetic ESO peptides (Vbeta4.1) and distinct from those used by highly tumor-reactive CTLs isolated from patients with spontaneous immune responses (Vbeta1.1, Vbeta8.1, and Vbeta13.1). Together, these results demonstrate that vaccination with the ESO protein elicits a repertoire of ESO 157-165-specific CTLs bearing T-cell receptors that are structurally distinct from those of CTLs found in spontaneous immune responses to the antigen and that are heterogeneous in terms of tumor reactivity, being often poorly tumor reactive.

  12. PR Crisis Melalui Media Sosial

    Directory of Open Access Journals (Sweden)

    Gladys Carlina

    2017-07-01

    Full Text Available The background of this research is communication, new media, PR and PR Crisis. Fourth of this background has a close relationship, starting from communication, human in everyday life would require communication to receive and convey information, human can not be released from human life. The advancement of the times and the development of technology, causing people to communicate easily and the development of this era caused a new challenge for the PR and PR Crisis of a company, they should be able to maintain a positive image of the company in the minds of people. In this study using descriptive qualitative methodology, it contains many writings and drawings compared to the numbers. The purpose of this research is to know the strategy used by Pizza Hut in dealing with the issue of expired food. Penelitin results, social media is very positive impact on Pizza Hut in the recovery of food issues expired. The strategy used by the Pizza Hut Crisis PR is to utilize social media. Visible from the issue of expired food that disappeared in public and Pizza Hut restaurant until now crowded visited. Latar belakang dari penelitian ini yaitu komunikasi, media baru, PR dan PR Krisis. Keempat dari latar belakang ini mempunyai hubungan yang erat, dimulai dari komunikasi, manusia di dalam kehidupan sehari-hari tentunya memerlukan komunikasi untuk menerima dan menyampaikan informasi, manusia tidak bisa dilepaskan dari kehidupan manusia. Majunya perkembangan zaman dan perkembangan teknologi, menyebabkan manusia melakukan komunikasi dengan mudah dan perkembangan zaman ini menyebabkan adanya tantangan baru bagi para PR dan PR Krisis sebuah perusahaan, mereka harus bisa mempertahankan citra positif perusahaan di benak masyarakat. Dalam penelitian ini menggunakan metodologi kualitatif deksriptif, memuat banyak tulisan dan gambar dibandingkan angka-angka. Tujuan dari penelitian ini untuk mengetahui strategi yang digunakan oleh Pizza Hut dalam menangani isu makanan

  13. A new mix of power for the ESO installations in Chile: greener, more reliable, cheaper

    Science.gov (United States)

    Filippi, G.; Tamai, R.; Kalaitzoglou, D.; Wild, W.; Delorme, A.; Rioseco, D.

    2016-07-01

    The highest sky quality demands for astronomical research impose to locate observatories often in areas not easily reached by the existing power infrastructures. At the same time, availability and cost of power is a primary factor for sustainable operations. Power may also be a potential source for CO2 pollution. As part of its green initiatives, ESO is in the process of replacing the power sources for its own, La Silla and Paranal-Armazones, and shared, ALMA, installations in Chile in order to provide them with more reliable, affordable, and smaller CO2 footprint power solutions. The connectivity to the Chilean interconnected power systems (grid) which is to extensively use Non-Conventional Renewable Energy (NCRE) as well as the use of less polluting fuels wherever self-generation cannot be avoided are key building blocks for the solutions selected for every site. In addition, considerations such as the environmental impact and - if required - the partnership with other entities have also to be taken into account. After years of preparatory work to which the Chilean Authorities provided great help and support, ESO has now launched an articulated program to upgrade the existing agreements/facilities in i) the La Silla Observatory, from free to regulated grid client status due to an agreement with a Solar Farm private initiative, in ii) the Paranal-Armazones Observatory, from local generation using liquefied petroleum gas (LPG) to connection to the grid which is to extensively use NCRE, and last but not least, in iii) the ALMA Observatory where ESO participates together with North American and East Asian partners, from replacing the LPG as fuel for the turbine local generation system with the use of less polluting natural gas (NG) supplied by a pipe connection to eliminate the pollution caused by the LPG trucks (currently 1 LPG truck from the VIII region, Bio Bio, to the II region, ALMA and back every day, for a total of 3000km). The technologies used and the status

  14. The Gaia-ESO Survey: Low-α element stars in the Galactic bulge

    Science.gov (United States)

    Recio-Blanco, A.; Rojas-Arriagada, A.; de Laverny, P.; Mikolaitis, S.; Hill, V.; Zoccali, M.; Fernández-Trincado, J. G.; Robin, A. C.; Babusiaux, C.; Gilmore, G.; Randich, S.; Alfaro, E.; Allende Prieto, C.; Bragaglia, A.; Carraro, G.; Jofré, P.; Lardo, C.; Monaco, L.; Morbidelli, L.; Zaggia, S.

    2017-06-01

    We take advantage of the Gaia-ESO Survey iDR4 bulge data to search for abundance anomalies that could shed light on the composite nature of the Milky Way bulge. The α-element (Mg, Si, and whenever available, Ca) abundances, and their trends with Fe abundances have been analysed for a total of 776 bulge stars. In addition, the aluminum abundances and their ratio to Fe and Mg have also been examined. Our analysis reveals the existence of low-α element abundance stars with respect to the standard bulge sequence in the [α/ Fe] versus [Fe/H] plane. Eighteen objects present deviations in [α/ Fe] ranging from 2.1 to 5.3σ with respect to the median standard value. Those stars do not show Mg-Al anti-correlation patterns. Incidentally, this sign of the existence of multiple stellar populations is reported firmly for the first time for the bulge globular cluster NGC 6522. The identified low-α abundance stars have chemical patterns that are compatible with those of the thin disc. Their link with massive dwarf galaxies accretion seems unlikely, as larger deviations in α abundance and Al would be expected. The vision of a bulge composite nature and a complex formation process is reinforced by our results. The approach used, which is a multi-method and model-driven analysis of high resolution data, seems crucial to reveal this complexity. Based on data products from observations made with ESO Telescopes at the La Silla Paranal Observatory under programme ID 188.B-3002. These data products have been processed by the Cambridge Astronomy Survey Unit (CASU) at the Institute of Astronomy, University of Cambridge, and by the FLAMES/UVES reduction team at INAF/Osservatorio Astrofisico di Arcetri. These data have been obtained from the Gaia-ESO Survey Data Archive, and prepared and hosted by the Wide Field Astronomy Unit, Institute for Astronomy, University of Edinburgh, which is funded by the UK Science and Technology Facilities Council.

  15. Gaia-ESO Survey: Gas dynamics in the Carina nebula through optical emission lines

    Science.gov (United States)

    Damiani, F.; Bonito, R.; Magrini, L.; Prisinzano, L.; Mapelli, M.; Micela, G.; Kalari, V.; Maíz Apellániz, J.; Gilmore, G.; Randich, S.; Alfaro, E.; Flaccomio, E.; Koposov, S.; Klutsch, A.; Lanzafame, A. C.; Pancino, E.; Sacco, G. G.; Bayo, A.; Carraro, G.; Casey, A. R.; Costado, M. T.; Franciosini, E.; Hourihane, A.; Lardo, C.; Lewis, J.; Monaco, L.; Morbidelli, L.; Worley, C.; Zaggia, S.; Zwitter, T.; Dorda, R.

    2016-06-01

    Aims: We present observations from the Gaia-ESO Survey in the lines of Hα, [N II], [S II], and He I of nebular emission in the central part of the Carina nebula. Methods: We investigate the properties of the two already known kinematic components (approaching and receding), which account for the bulk of emission. Moreover, we investigate the features of the much less known low-intensity high-velocity (absolute RV >50 km s-1) gas emission. Results: We show that gas giving rise to Hα and He I emission is dynamically well correlated with but not identical to gas seen through forbidden-line emission. Gas temperatures are derived from line-width ratios, and densities from [S II] doublet ratios. The spatial variation of N ionization is also studied, and found to differ between the approaching and receding components. The main result is that the bulk of the emission lines in the central part of Carina arise from several distinct shell-like expanding regions, the most evident found around η Car, the Trumpler 14 core, and the star WR25. These "shells" are non-spherical and show distortions probably caused by collisions with other shells or colder, higher-density gas. Some of them are also partially obscured by foreground dust lanes, while very little dust is found in their interior. Preferential directions, parallel to the dark dust lanes, are found in the shell geometries and physical properties, probably related to strong density gradients in the studied region. We also find evidence that the ionizing flux emerging from η Car and the surrounding Homunculus nebula varies with polar angle. The high-velocity components in the wings of Hα are found to arise from expanding dust reflecting the η Car spectrum. Based on observations collected with the FLAMES spectrograph at VLT/UT2 telescope (Paranal Observatory, ESO, Chile), for the Gaia-ESO Large Public Survey (program 188.B-3002).Full Tables 1-3 are only available at the CDS via anonymous ftp to http

  16. NY-ESO-1抗原的基础与临床研究进展%Current advances in basic and clinical study of NY-ESO-1

    Institute of Scientific and Technical Information of China (English)

    虞淦军

    2015-01-01

    NY-ESO-1是癌-睾丸抗原家族中的重要一员,在多种肿瘤组织中广泛表达,但在正常组织中几乎不表达.目前已经发现了20多个抗原表位,并在多种肿瘤患者体内检测到自发性免疫反应,包括体液和细胞免疫反应,NY-ESO-1的表达及体内自发性免疫应答被证实与肿瘤的诊断和预后有重要关联.NY-ESO-1被认为是肿瘤免疫治疗的理想靶抗原,以NY-ESO-1抗原为靶点的肿瘤治疗性疫苗、TCR基因修饰的T细胞、CAR修饰的T细胞等临床研究相继开展,展示了良好的前景.

  17. The Gaia-ESO Survey: the most metal-poor stars in the Galactic bulge

    CERN Document Server

    Howes, L; Casey, A R; Keller, S C; Yong, D; Gilmore, G; Lind, K; Worley, C; Bessell, M S; Casagrande, L; Marino, A F; Nataf, D M; Owen, C I; Da Costa, G S; Schmidt, B P; Tisserand, P; Randich, S; Feltzing, S; Vallenari, A; Prieto, C Allende; Bensby, T; Flaccomio, E; Korn, A J; Pancino, E; Recio-Blanco, A; Smiljanic, R; Bergemann, M; Costado, M T; Damiani, F; Heiter, U; Hill, V; Hourihane, A; Jofré, P; Lardo, C; de Laverny, P; Magrini, L; Maiorca, E; Masseron, T; Morbidelli, L; Sacco, G G; Minniti, D; Zoccali, M

    2014-01-01

    We present the first results of the EMBLA survey (Extremely Metal-poor BuLge stars with AAOmega), aimed at finding metal-poor stars in the Milky Way bulge, where the oldest stars should now preferentially reside. EMBLA utilises SkyMapper photometry to pre-select metal-poor candidates, which are subsequently confirmed using AAOmega spectroscopy. We describe the discovery and analysis of four bulge giants with -2.72<=[Fe/H]<=-2.48, the lowest metallicity bulge stars studied with high-resolution spectroscopy to date. Using FLAMES/UVES spectra through the Gaia-ESO Survey we have derived abundances of twelve elements. Given the uncertainties, we find a chemical similarity between these bulge stars and halo stars of the same metallicity, although the abundance scatter may be larger, with some of the stars showing unusual [{\\alpha}/Fe] ratios.

  18. The Gaia-ESO Survey: CNO Abundances in Open Clusters of our Galaxy

    Science.gov (United States)

    Drazdauskas, A.; Tautvaišienė, G.; Mikolaitis, Š.; Barisevičius, G.; Puzeras, E.; Stonkutė, E.; Chorniy, Y.; GES Collaborators

    2016-10-01

    We present the current status of CNO abundance investigations in evolved stars of Galactic open clusters observed in the currently ongoing Gaia-ESO survey. The spectra were observed with the VLT UVES spectrograph and analysed using a differential model atmosphere method. The C/N ratios of stars in the investigated open clusters were compared with the ratios predicted by stellar evolutionary models. For the corresponding stellar turn-off masses from 1.15 to 3.3 M⊙, the observed C/N ratio values are close to the predictions of standard first dredge-up and thermohaline extra-mixing models. The recent model in which the thermohaline- and rotation-induced extra-mixing act together seems to provide C/N values that are too low.

  19. ASASSN-16km: Discovery of A Supernova in ESO 197-G 010

    Science.gov (United States)

    Brown, J. S.; Prieto, J. L.; Ricci, C.; Oh, K.; Stanek, K. Z.; Holoien, T. W.-S.; Kochanek, C. S.; Shields, J.; Shappee, B. J.; Bersier, D.; Dong, Subo; Bose, S.; Chen, Ping; Brimacombe, J.

    2016-09-01

    During the ongoing All Sky Automated Survey for SuperNovae (ASAS-SN or "Assassin"), using data from the quadruple 14-cm "Cassius" telescope in Cerro Tololo, Chile, we discovered a Type Ia supernova in the galaxy ESO 197-G 010. ASASSN-16km (AT 2016ggb) was discovered in images obtained on UT 2016-09-12.34 at V~16.3 mag. We also detect the object in images obtained on UT 2016-09-13.15 (V~16.2), UT 2016-09-10.15 (V~16.3), UT 2016-09-09.15 (V~16.6), UT 2016-09-05.110 (V~17.1), and UT 2016-09-02.41 (V~17.6).

  20. A List of Bright Interferometric Calibrators measured at the ESO VLTI

    CERN Document Server

    Richichi, A; Davis, J

    2009-01-01

    In a previous publication (Richichi & Percheron 2005) we described a program of observations of candidate calibrator stars at the ESO Very Large Telescope Interferometer (VLTI), and presented the main results from a statistical point of view. In the present paper, we concentrate on establishing a new homogeneous group of bright interferometric calibrators, based entirely on publicly available K-band VLTI observations carried out with the VINCI instrument up to July 2004. For this, we have defined a number of selection criteria for the quality and volume of the observations, and we have accordingly selected a list of 17 primary and 47 secondary calibrators. We have developed an approach to a robust global fit for the angular diameters using the whole volume of quality-controlled data, largely independent of a priori assumptions. Our results have been compared with direct measurements, and indirect estimates based on spectrophotometric methods, and general agreement is found within the combined uncertaintie...

  1. First Science with SAMI: A Serendipitously Discovered Galactic Wind in ESO 185-G031

    CERN Document Server

    Fogarty, Lisa M R; Croom, Scott M; Green, Andrew W; Bryant, Julia J; Lawrence, Jon S; Richards, Samuel; Allen, James T; Bauer, Amanda E; Birchall, Michael N; Brough, Sarah; Colless, Matthew; Ellis, Simon C; Farrell, Tony; Goodwin, Michael; Heald, Ron; Hopkins, Andrew M; Horton, Anthony; Jones, D Heath; Lee, Steve; Lewis, Geraint; López-Sánchez, Ángel R; Miziarski, Stan; Trowland, Holly; Leon-Saval, Sergio G; Min, Seong-Sik; Trinh, Christopher; Cecil, Gerald; Veilleux, Sylvain; Kreimeyer, Kory

    2012-01-01

    We present the first scientific results from the Sydney-AAO Multi-Object IFS (SAMI) at the Anglo-Australian Telescope. This unique instrument deploys 13 fused fibre bundles (hexabundles) across a one-degree field of view allowing simultaneous spatially-resolved spectroscopy of 13 galaxies. During the first SAMI commissioning run, targeting a single galaxy field, one object (ESO 185-G031) was found to have extended minor axis emission with ionisation and kinematic properties consistent with a large-scale galactic wind. The importance of this result is two-fold: (i) fibre bundle spectrographs are able to identify low-surface brightness emission arising from extranuclear activity; (ii) such activity may be more common than presently assumed because conventional multi-object spectrographs use single-aperture fibres and spectra from these are nearly always dominated by nuclear emission. These early results demonstrate the extraordinary potential of multi-object hexabundle spectroscopy in future galaxy surveys.

  2. PROPUESTA DIDÁCTICA PARA ENSEÑAR POLINOMIOS A 3º ESO UTILIZANDO EDUSLIDE

    OpenAIRE

    Martín-Santaolaya, Rosa Amparo

    2013-01-01

    En este trabajo se elabora una propuesta didáctica interactiva para enseñar polinomios a alumnos cursando 3º de la ESO, con apoyo de Eduslide como metodología para la didáctica de matemáticas. Eduslide es una plataforma interactiva, tecnología Web 2.0., que permite crear cursos de forma gratuita. La intención didáctica con la que se diseña la plataforma es dotar al álgebra de significación y asegurar la correcta transición desde el área de la aritmética. Por tanto, en la primer...

  3. Extinction in SC galaxies - an analysis of the ESO-LV data

    Science.gov (United States)

    Huizinga, J. E.; van Albada, T. S.

    1992-02-01

    The surface photometry of Sc galaxies in the ESO-LV database in view of recent claims by Valentijn that spiral galaxies are opaque over their entire disks is analyzed. Using diameter-limited and magnitude-limited subsamples, it can discriminate between the opaque and transparent cases with the axis-ratio distribution test. Results support the traditional view that Sc galaxies are semitransparent, but the brightness difference between face-on and edge-on can be as large as 1.0 to 1.5 mag. Analyzing surface-brightness profiles at various radii, it is seen that the central regions are essentially opaque, and the outer regions nearly fully transparent. It is shown that conclusions differ from those of Valentijn, because of neglect to take secondary inclination effects into account.

  4. Validation Through Simulations of a Cn2 Profiler for the ESO/VLT Adaptive Optics Facility

    CERN Document Server

    Garcia-Rissmann, A; Kolb, J; Louarn, M Le; Madec, P -Y; Neichel, B

    2015-01-01

    The Adaptive Optics Facility (AOF) project envisages transforming one of the VLT units into an adaptive telescope and providing its ESO (European Southern Observatory) second generation instruments with turbulence corrected wavefronts. For MUSE and HAWK-I this correction will be achieved through the GALACSI and GRAAL AO modules working in conjunction with a 1170 actuators Deformable Secondary Mirror (DSM) and the new Laser Guide Star Facility (4LGSF). Multiple wavefront sensors will enable GLAO and LTAO capabilities, whose performance can greatly benefit from a knowledge about the stratification of the turbulence in the atmosphere. This work, totally based on end-to-end simulations, describes the validation tests conducted on a Cn2 profiler adapted for the AOF specifications. Because an absolute profile calibration is strongly dependent on a reliable knowledge of turbulence parameters r0 and L0, the tests presented here refer only to normalized output profiles. Uncertainties in the input parameters inherent t...

  5. The Gaia-ESO Survey: A simple explanation for the Li-rich giant problem

    DEFF Research Database (Denmark)

    Casey, Andrew R.; Ruchti, G.; Masseron, T.;

    2016-01-01

    of evidence actually predict the existence of Li-rich giants, and suggests they should be preferentially found before the luminosity bump at near-solar metallicities, consistent with observations. This scenario explains (indeed, predicts) the majority properties of Li-rich giants, leaving a minority...... observed through the Gaia-ESO Survey. Our sample is one of the largest in the literature, and includes nine towards the CoRoT fields. We explore all mechanisms proposed to explain Li-rich giants. While the planet accretion scenario was presented to reconcile observations of Li-rich giants across the RGB....../AGB, this is inconsistent with recent studies of close-in giant planets. We highlight recent observations of the difference in hot Jupiter occurrence rates around dwarf and sub-giant stars as evidence for their tidal destruction when the convective envelope expands. Therefore any close-in giant planet is likely...

  6. 经理人股票期权(ESO)的会计确认

    Institute of Scientific and Technical Information of China (English)

    夏营

    2013-01-01

    ESO的会计确认是一个具有争议性和挑战性的财务会计领域.本文在深入分析会计确认问题基础之上,指出ESO的经济实质是经理人参与企业利润索取权分享的重要形式,并选择了“利润分配观”作为ESO会计确认的方法,既反映ESO的经济实质,也是ESO确认的发展趋势.同时对我国的ESO会计确认提出了可行性建议.

  7. ASASSN-16of: Discovery of A Probable Supernova in ESO 087-IG 041

    Science.gov (United States)

    Kiyota, S.; Brown, J. S.; Stanek, K. Z.; Holoien, T. W.-S.; Kochanek, C. S.; Shields, J.; Shappee, B. J.; Prieto, J. L.; Bersier, D.; Dong, Subo; Bose, S.; Chen, Ping; Brimacombe, J.; Masi, G.; Post, R. S.; Stone, G.

    2016-12-01

    During the ongoing All Sky Automated Survey for SuperNovae (ASAS-SN or "Assassin"), using data from the quadruple 14-cm "Cassius" telescope in Cerro Tololo, Chile, we discovered a new transient source, most likely a supernova, in the galaxy ESO 087-IG 041. ASASSN-16of (AT 2016iqx) was discovered in images obtained on UT 2016-12-01.28 at V 16.7 mag. We also detect the object in images obtained on UT 2016-11-30.35 (V 16.8), UT 2016-11-28.28 (V 16.7), UT 2016-11-24.27 (V 17.0), UT 2016-11-22.23 (V 16.6), and UT 2016-11-19.34 (V 17.1).

  8. The old metal-poor open cluster ESO 92-SC05: accreted from a dwarf galaxy?

    CERN Document Server

    ortolani, S; Barbuy, B

    2008-01-01

    The study of old open clusters outside the solar circle can bring constraints on formation scenarios of the outer disk. In particular, accretion of dwarf galaxies has been proposed as a likely mechanism in the area. We use BVI photometry for determining fundamental parameters of the faint open cluster ESO 92-SC05. Colour-Magnitude Diagrams are compared with Padova isochrones, in order to derive age, reddening and distance. We derive a reddening E(B-V)= 0.17, and an old age of $\\sim$6.0 Gyr. It is one of the rare open clusters known to be older than 5 Gyr. A metallicity of Z$\\sim$0.004 or [M/H]$\\sim$-0.7 is found. The rather low metallicity suggests that this cluster might be the result of an accretion episode of a dwarf galaxy.

  9. 5-Aza-CdR induced expression of NY-ESO-1 antigen in tumor cells%5-Aza-CdR诱导肿瘤细胞NY-ESO-1抗原的表达

    Institute of Scientific and Technical Information of China (English)

    陈裕庆; 黄丽; 汪晓军; 张文敏

    2010-01-01

    目的:探讨甲基化抑制剂5-氮杂-2'-脱氧胞苷(5-Aza-2'-deoxycytidine,5-Aza-CdR)对肿瘤细胞中NY-ESO-1抗原表达的诱导作用.方法:常规培养人胃癌细胞株SGC-7901、人肝癌细胞株H2P和MHCC97-H、人结肠癌细胞株HT-29和LoVo及人脑胶质瘤细胞株U251,RT-PCR和免疫细胞化学法检测5-Aza-CdR作用前后肿瘤细胞中NY-ESO-1 mRNA和蛋白的表达.结果:RT-PCR与免疫细胞化学检测仅见胃癌SGC-7901细胞阳性表达NY-ESO-1,其余5株肿瘤细胞不表达NY-ESO-1.NY-ESO-1阴性的肝癌细胞株H2P、结肠癌细胞株LoVo及脑胶质瘤细胞株U251经5-Aza-CdR(终浓度分别为1、5和10 μmol/L)处理6 d后,细胞形态和生长速度均无明显改变,而NY-ESO-1 mRNA和蛋白均被诱导为阳性表达,并随5-Aza-CdR浓度增加而阳性表达逐渐增强.结论:5-Aza-CdR能诱导肝癌、结肠癌、脑胶质瘤等肿瘤细胞中NY-ESO-1抗原的表达,为肿瘤免疫治疗提供了一条新思路.

  10. Antigen-specific in vitro expansion of functional redirected NY-ESO-1-specific human CD8+ T-cells in a cell-free system.

    Science.gov (United States)

    Jakka, Gopinadh; Schuberth, Petra C; Thiel, Markus; Held, Gerhard; Stenner, Frank; Van Den Broek, Maries; Renner, Christoph; Mischo, Axel; Petrausch, Ulf

    2013-10-01

    Tumors can be targeted by the adoptive transfer of chimeric antigen receptor (CAR) redirected T-cells. Antigen-specific expansion protocols are needed to generate large quantities of redirected T-cells. We aimed to establish a protocol to expand functional active NY-ESO-1-specific redirected human CD8(+) T-cells. The anti-idiotypic Fab antibody A4 with specificity for HLA-A 0201/NY-ESO-1157-165 was tested by competition assays using a HLA-A 0201/NY-ESO-1157-165 tetramer. HLA-A 0201/NY-ESO-1157-165 redirected T-cells were generated, expanded and tested for CAR expression, cytokine release, in vitro cytolysis and protection against xenografted HLA-A 0201/NY-ESO-1157-165-positive multiple myeloma cells. A4 demonstrated antigen-specific binding to HLA-A 0201/NY-ESO-1157-165 redirected T-cells. Expansion with A4 resulted in 98% of HLA-A 0201/NY-ESO-1157-165 redirected T-cells. A4 induced strong proliferation, resulting in a 300-fold increase of redirected T-cells. After expansion protocols, redirected T-cells secreted Interleukin-2, (IL-2), interferon gamma (IFNγ) and tumor necrosis factor alpha (TNFα) and lysed target cells in vitro and were protective in vivo. A4 expanded HLA-A 0201/NY-ESO-1157-165 redirected T-cells with preservation of antigen-specific function.

  11. Allorestricted T lymphocytes with a high avidity T-cell receptor towards NY-ESO-1 have potent anti-tumor activity.

    Science.gov (United States)

    Krönig, Holger; Hofer, Kathrin; Conrad, Heinke; Guilaume, Philippe; Müller, Julia; Schiemann, Matthias; Lennerz, Volker; Cosma, Antonio; Peschel, Christian; Busch, Dirk H; Romero, Pedro; Bernhard, Helga

    2009-08-01

    The cancer-testis antigen NY-ESO-1 has been targeted as a tumor-associated antigen by immunotherapeutical strategies, such as cancer vaccines. The prerequisite for a T-cell-based therapy is the induction of T cells capable of recognizing the NY-ESO-1-expressing tumor cells. In this study, we generated human T lymphocytes directed against the immunodominant NY-ESO-1(157-165) epitope known to be naturally presented with HLA-A*0201. We succeeded to isolate autorestricted and allorestricted T lymphocytes with low, intermediate or high avidity TCRs against the NY-ESO-1 peptide. The avidity of the established CTL populations correlated with their capacity of lysing HLA-A2-positive, NY-ESO-1-expressing tumor cell lines derived from different origins, e.g. melanoma and myeloma. The allorestricted NY-ESO-1-specific T lymphocytes displayed TCRs with the highest avidity and best anti-tumor recognition activity. TCRs derived from allorestricted, NY-ESO-1-specific T cells may be useful reagents for redirecting primary T cells by TCR gene transfer and, therefore, may facilitate the development of adoptive transfer regimens based on TCR-transduced T cells for the treatment of NY-ESO-1-expressing hematological malignancies and solid tumors.

  12. The Gaia-ESO Survey: the inner disk, intermediate-age open cluster Trumpler 23

    Science.gov (United States)

    Overbeek, J. C.; Friel, E. D.; Donati, P.; Smiljanic, R.; Jacobson, H. R.; Hatzidimitriou, D.; Held, E. V.; Magrini, L.; Bragaglia, A.; Randich, S.; Vallenari, A.; Cantat-Gaudin, T.; Tautvaišienė, G.; Jiménez-Esteban, F.; Frasca, A.; Geisler, D.; Villanova, S.; Tang, B.; Muñoz, C.; Marconi, G.; Carraro, G.; San Roman, I.; Drazdauskas, A.; Ženovienė, R.; Gilmore, G.; Jeffries, R. D.; Flaccomio, E.; Pancino, E.; Bayo, A.; Costado, M. T.; Damiani, F.; Jofré, P.; Monaco, L.; Prisinzano, L.; Sousa, S. G.; Zaggia, S.

    2017-02-01

    Context. Trumpler 23 is a moderately populated, intermediate-age open cluster within the solar circle at a RGC 6 kpc. It is in a crowded field very close to the Galactic plane and the color-magnitude diagram shows significant field contamination and possible differential reddening; it is a relatively understudied cluster for these reasons, but its location makes it a key object for determining Galactic abundance distributions. Aims: New data from the Gaia-ESO Survey enable the first ever radial velocity and spectroscopic metallicity measurements for this cluster. We aim to use velocities to isolate cluster members, providing more leverage for determining cluster parameters. Methods: Gaia-ESO Survey data for 167 potential members have yielded radial velocity measurements, which were used to determine the systemic velocity of the cluster and membership of individual stars. Atmospheric parameters were also used as a check on membership when available. Literature photometry was used to re-determine cluster parameters based on radial velocity member stars only; theoretical isochrones are fit in the V, V-I diagram. Cluster abundance measurements of ten radial-velocity member stars with high-resolution spectroscopy are presented for 24 elements. These abundances have been compared to local disk stars, and where possible placed within the context of literature gradient studies. Results: We find Trumpler 23 to have an age of 0.80 ± 0.10 Gyr, significant differential reddening with an estimated mean cluster E(V-I) of 1.02, and an apparent distance modulus of 14.15 ± 0.20. We find an average cluster metallicity of [Fe/H] = 0.14 ± 0.03 dex, a solar [α/Fe] abundance, and notably subsolar [s-process/Fe] abundances.

  13. Curva de rotação óptica de ESO-LV 5100550

    Science.gov (United States)

    Carvalho, D. B.; Soares, D. S. L.

    2003-08-01

    ESO-LV 5100550 é o membro mais fraco do par de galáxias austral SBG 357 (Soares et al. 1995). É classificada no catálogo RC3 como uma espiral ordinária de tipo inicial (early-type); porém, uma análise morfológica sugere que ela tenha uma grande barra. O objetivo do estudo é determinar sua cinemática de tal modo que possamos inferir mais a respeito de sua dinâmica, provavelmente perturbada, já que se espera que esteja sob forte influência da companheira ESO-LV 5100560. Apresentarei resultados parciais determinados a partir de espectros obtidos com o instrumento Double Spectrograph montado no telescópio Hale do Monte Palomar, EUA. As observações foram realizadas por D.S.L. Soares, P.M.V. Veiga e T.E. Nordgren, em 1998. Foram tomados espectros de fenda longa posicionada sobre a linha dos nodos do disco e ao longo da suposta barra. Os dados foram reduzidos com uso do pacote IRAF. Obtivemos o perfil de velocidades radiais na linha de visada ao longo das fendas e calculamos o desvio para o vermelho cosmológico do sistema, com base no espectro central. Determinamos as curvas de rotação deprojetadas, com base em cálculos para os valores teóricos esperados das componentes de velocidades puramente circulares em um disco inclinado. A inclinação do disco, dado fundamental nesta deprojeção, foi estimada através da média das elipticidades das isofotas mais externas.

  14. Polarimetric view of the changing type Seyfert galaxy ESO 362-G018.

    Science.gov (United States)

    Agís-González, B.; Bagnulo, S.; Hutsemékers, D.; Montesinos, B.; Miniutti, G.; Sanfrutos, M.

    2017-03-01

    ESO362-G018 is an active galactic nucleus (AGN) which is classified as a Seyfert 1.5 galaxy e.g. by Bennert et al. (2006), (black data set on figure 1). However, Parisi et. al (2009) found an optical spectrum of this source which was taken during the 6dF Galaxy Survey, but it does not show the broad Balmer lines required to classify it as Seyfert 1 galaxy (red data set on figure 1). On the other hand, the results obtained by Agis-Gonzalez et al. (2014❩ in a X-ray analysis of this same source reveal that the inclination of ESO362- G018 i = 53° ± 5° is consistent with the picture of an AGN looked through the upper layers of a clumpy, dusty torus. Thus, according to the Unification Models of AGN and the clumpy nature of the torus, our interpretation of the different spectra is the following one. On 30th of January of 2003 (when the spectrum belonging to the 6dF survey was obtained), our line of sight intercepted a (or several aligned) torus clump(s) with much greater column density than its environment. Accordingly, the nucleus and the broad line region (❨BLR)❩ would be obscured. This allowed only the narrow emission lines to emerge from the narrow line region (NRL). Otherwise, on 18th of September of 2004 (when the spectrum by Bennert et al. 2006 was obtained) there is no clump to intercept and the BLR is not obscured so that the broad Balmer emission lines could be detected.

  15. The Gaia-ESO Survey: Galactic evolution of sulphur and zinc

    Science.gov (United States)

    Duffau, S.; Caffau, E.; Sbordone, L.; Bonifacio, P.; Andrievsky, S.; Korotin, S.; Babusiaux, C.; Salvadori, S.; Monaco, L.; François, P.; Skúladóttir, Á.; Bragaglia, A.; Donati, P.; Spina, L.; Gallagher, A. J.; Ludwig, H.-G.; Christlieb, N.; Hansen, C. J.; Mott, A.; Steffen, M.; Zaggia, S.; Blanco-Cuaresma, S.; Calura, F.; Friel, E.; Jiménez-Esteban, F. M.; Koch, A.; Magrini, L.; Pancino, E.; Tang, B.; Tautvaišienė, G.; Vallenari, A.; Hawkins, K.; Gilmore, G.; Randich, S.; Feltzing, S.; Bensby, T.; Flaccomio, E.; Smiljanic, R.; Bayo, A.; Carraro, G.; Casey, A. R.; Costado, M. T.; Damiani, F.; Franciosini, E.; Hourihane, A.; Jofré, P.; Lardo, C.; Lewis, J.; Morbidelli, L.; Sousa, S. G.; Worley, C. C.

    2017-08-01

    Context. Due to their volatile nature, when sulphur and zinc are observed in external galaxies, their determined abundances represent the gas-phase abundances in the interstellar medium. This implies that they can be used as tracers of the chemical enrichment of matter in the Universe at high redshift. Comparable observations in stars are more difficult and, until recently, plagued by small number statistics. Aims: We wish to exploit the Gaia-ESO Survey (GES) data to study the behaviour of sulphur and zinc abundances of a large number of Galactic stars, in a homogeneous way. Methods: By using the UVES spectra of the GES sample, we are able to assemble a sample of 1301 Galactic stars, including stars in open and globular clusters in which both sulphur and zinc were measured. Results: We confirm the results from the literature that sulphur behaves as an α-element. We find a large scatter in [Zn/Fe] ratios among giant stars around solar metallicity. The lower ratios are observed in giant stars at Galactocentric distances less than 7.5 kpc. No such effect is observed among dwarf stars, since they do not extend to that radius. Conclusions: Given the sample selection, giants and dwarfs are observed at different Galactic locations, and it is plausible, and compatible with simple calculations, that Zn-poor giants trace a younger population more polluted by SN Ia yields. It is necessary to extend observations in order to observe both giants and dwarfs at the same Galactic location. Further theoretical work on the evolution of zinc is also necessary. Based on observations collected at the European Organisation for Astronomical Research in the Southern Hemisphere under ESO programmes 188.B-3002, 193.B-0936.The full table of S abundances is only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/604/A128

  16. pCDNA3.1/NY-ESO-1真核表达质粒的构建及在肝癌细胞系HepG2中稳定高表达%To construct the eukaryotic expression plasmid pCDNA3.1/NY-ESO-1 and to establish a NY-ESO-1 highly expressed HepG2 cell line

    Institute of Scientific and Technical Information of China (English)

    徐珩; 杨硕; 顾娜; 冯丹丹; 闾军; 汪思应

    2010-01-01

    目的 建立癌-睾丸抗原NY-ESO-1稳定表达的HepG2肝癌细胞系.方法 设计NY-ESO-1的引物,PCR法从NY-ESO-1阳性表达的睾丸癌组织中扩增出目的片段,克隆至T载体,双酶切后定向连入pCDNA3.1载体,构建pCDNA3.1/NY-ESO-1真核表达质粒.经酶切、PCR、测序检测其构建的正确性,脂质体转染法将重组质粒转入HepG2细胞,G418药物筛选出稳定转染的细胞系,RT-PCR法、间接免疫荧光法分别检测稳定转染HepG2细胞中NY-ESO-1基因、蛋白的表达水平.结果 构建的pCDNA3.1/NY-ESO-1质粒经酶切、测序等检验表明质粒构建成功,筛选获得稳定高表达NY-ESO-1的HepG2细胞.结论 构建了pCDNA3.1/NY-ESO-1真核表达质粒及稳定高表达NY-ESO-1的HepG2细胞株,为下一步以NY-ESO-1为靶标进行肝癌的抗原特异性免疫治疗研究奠定了实验基础.

  17. Digitale prøver - et litteraturstudie

    DEFF Research Database (Denmark)

    Møller, Karen Louise; Mikkelsen, Thomas

    2015-01-01

    bl.a. om udfordringer hvad angår prøvesystem, organisation, teknologi, kompetenceudvikling og uddannelseskultur. Vi beskriver i artiklen en række konkrete eksempler på digitale prøver, og vi præsenterer resultater fra undersøgelser af underviseres og studerendes oplevelser med digitale prøveformer....

  18. Live Webcasts from CERN and ESO for European Science and Technology Week

    Science.gov (United States)

    2002-10-01

    Visit http://www.cern.ch/sci-tech on 7 - 8 November to find out what modern Europeans can't live without. Seven of Europe's leading Research Organizations [1] are presenting three live Webcasts from CERN in a joint outreach programme for the European Science and Technology Week . The aim of Sci-Tech... couldn't be without it! is to show how today's society couldn't be without cutting-edge scientific research. See also ESO Press Release 05/02. Northern Europeans can't imagine their households without ovens, whereas Southern Europeans identify the refrigerator as the most essential household appliance. In the area of communications, cars and motorbikes are clearly the technologies of choice in Italy, but are regarded as less important in countries like Norway and Germany. For entertainment, the personal computer is a clear winner as the device is considered most essential by all Europeans, followed by the TV and the Internet. This hit parade of technological marvels is the result of a phone and online survey conducted by the Sci-Tech... couldn't be without it! team for this year's European Science and Technology Week on 4-10 November. The technologies Europeans could not be without, form the starting point of three entertaining and informative Webcast shows in Italian (Thursday 7 November at 10:00 CET), French (Thursday 7 November at 15:00 CET) and English (Friday 8 November at 15:00 CET), broadcast live on the Internet from a studio at CERN. During these Webcasts scientists from the seven research Organizations and their industrial partners Sun Microsystems, Siemens, L'Oreal and Luminex will engage - from the CERN studio or from remote locations through teleconference links - an audience of Internauts all over the world. The public will be taken inside their most popular gadgets to discover the science that made them possible and how vital fundamental research has been in the creation of modern technology. Fundamental science will be brought as close as possible to

  19. A pilot study of peripheral blood BDCA-1 (CD1c) positive dendritic cells pulsed with NY-ESO-1 ISCOMATRIX™ adjuvant.

    Science.gov (United States)

    Davis, Ian D; Quirk, Juliet; Morris, Leone; Seddon, Lauren; Tai, Tsin Yee; Whitty, Genevieve; Cavicchiolo, Tina; Ebert, Lisa; Jackson, Heather; Browning, Judy; MacGregor, Duncan; Wittke, Frederick; Winkels, Gregor; Alex, Regina; Miloradovic, Lena; Maraskovsky, Eugene; Chen, Weisan; Cebon, Jonathan

    2017-03-01

    Pilot clinical trial of NY-ESO-1 (ESO) protein in ISCOMATRIX™ adjuvant pulsed onto peripheral blood dendritic cells (PBDC), to ascertain feasibility, evaluate toxicity and assess induction of ESO-specific immune responses. Eligible participants had resected cancers expressing ESO or LAGE-1 and were at high risk of relapse. PBDC were produced using CliniMACS(®)plus, with initial depletion of CD1c(+) B cells followed by positive selection of CD1c(+) PBDC. Patients received three intradermal vaccinations of ESO/IMX-pulsed PBDC at 4-week intervals. The process was feasible and safe. No vaccine-induced immune responses were detected. Assays of immunomodulatory cells did not correlate with outcomes. One patient had a long lasting complete remission. This method was feasible and safe but was minimally immunogenic.

  20. Análisis Cuantitativo del Perfil Emocional Matemático en Alumnos de 4º de ESO.

    OpenAIRE

    Vela Manso, Lucas

    2015-01-01

    En este trabajo se lleva a cabo una investigación cuantitativa, a partir de los datos obtenidos mediante un cuestionario, del perfil emocional matemático de alumnos de 4º de la ESO y su relación con el rendimiento. Se analizan las siguientes variables: actitudes, autoconcepto, metacognición y creencias, junto con el rendimiento.

  1. Extinction in the Galaxy from Surface Brightnesses of ESO-LV Galaxies : Determination of A_R/A_B ratio

    NARCIS (Netherlands)

    Choloniewski, J.; Valentijn, E. A.

    2003-01-01

    A new method for the determination of the extinction in the Galaxy is proposed. The method uses surface brightnesses of external galaxies in the B and R-bands. The observational data have been taken from the ESO-LV galaxy catalog. As a first application of our model we derive the ratio of R-band to

  2. VizieR Online Data Catalog: KiDS-ESO-DR2 multi-band source catalog (de Jong+, 2015)

    NARCIS (Netherlands)

    de Jong, J. T. A.; Verdoes Kleijn, G. A.; Boxhoorn, D. R.; Buddelmeijer, H.; Capaccioli, M.; Getman, F.; Grado, A.; Helmich, E.; Huang, Z.; Irisarri, N.; Kuijken, K.; La Barbera, F.; McFarland, J. P.; Napolitano, N. R.; Radovich, M.; Sikkema, G.; Valentijn, E. A.; Begeman, K. G.; Brescia, M.; Cavuoti, S.; Choi, A.; Cordes, O.-M.; Covone, G.; Dall'Ora, M.; Hildebrandt, H.; Longo, G.; Nakajima, R.; Paolillo, M.; Puddu, E.; Rifatto, A.; Tortora, C.; van Uitert, E.; Buddendiek, A.; Harnois-Deraps, J.; Erben, T.; Eriksen, M. B.; Heymans, C.; Hoekstra, H.; Joachimi, B.; Kitching, T. D.; Klaes, D.; Koopmans, L. V. E.; Koehlinger, F.; Roy, N.; Sifon, C.; Schneider, P.; Sutherland, W. J.; Viola, M.; Vriend, W.-J.

    2017-01-01

    KiDS data releases consist of ~1 square degree tiles that have been successfully observed in all four survey filters (u,g,r,i). The second data release (KiDS-ESO-DR2) was available in February 2015 and contains imaging data, masks and single-band source lists for all tiles observed in all four

  3. A Grid of NLTE Corrections for Sulphur Lines in Atmospheres of Cool Stars for the Gaia-ESO Survey

    Science.gov (United States)

    Korotin, S.; Andrievsky, S.; Caffau, E.; Bonifacio, P.

    2017-06-01

    To derive sulfur abundance in a large amount of the stars from Gaia-ESO survey we calculated grid of theoretical line equivalent widths of 8th multiplet. We show that NLTE effects increase equivalent widths of the sulfur lines. NLTE corrections for this multiplet are not too large (about 0.15 dex) in contrast with corrections for other sulfur multiplets.

  4. Machine-learning-based photometric redshifts for galaxies of the ESO Kilo-Degree Survey data release 2

    NARCIS (Netherlands)

    Cavuoti, S.; Brescia, M.; Tortora, C.; Longo, G.; Napolitano, N. R.; Radovich, M.; Barbera, F. La; Capaccioli, M.; de Jong, J. T. A.; Getman, F.; Grado, A.; Paolillo, M.

    2015-01-01

    We have estimated photometric redshifts (zphot) for more than 1.1 million galaxies of the public European Southern Observatory (ESO) Kilo-Degree Survey (KiDS) data release 2. KiDS is an optical wide-field imaging survey carried out with the Very Large Telescope (VLT) Survey Telescope (VST) and the O

  5. Machine-learning-based photometric redshifts for galaxies of the ESO Kilo-Degree Survey data release 2

    NARCIS (Netherlands)

    Cavuoti, S.; Brescia, M.; Tortora, C.; Longo, G.; Napolitano, N. R.; Radovich, M.; Barbera, F. La; Capaccioli, M.; de Jong, J. T. A.; Getman, F.; Grado, A.; Paolillo, M.

    We have estimated photometric redshifts (zphot) for more than 1.1 million galaxies of the public European Southern Observatory (ESO) Kilo-Degree Survey (KiDS) data release 2. KiDS is an optical wide-field imaging survey carried out with the Very Large Telescope (VLT) Survey Telescope (VST) and the

  6. Back-stepping active disturbance rejection control design for integrated missile guidance and control system via reduced-order ESO.

    Science.gov (United States)

    Xingling, Shao; Honglun, Wang

    2015-07-01

    This paper proposes a novel composite integrated guidance and control (IGC) law for missile intercepting against unknown maneuvering target with multiple uncertainties and control constraint. First, by using back-stepping technique, the proposed IGC law design is separated into guidance loop and control loop. The unknown target maneuvers and variations of aerodynamics parameters in guidance and control loop are viewed as uncertainties, which are estimated and compensated by designed model-assisted reduced-order extended state observer (ESO). Second, based on the principle of active disturbance rejection control (ADRC), enhanced feedback linearization (FL) based control law is implemented for the IGC model using the estimates generated by reduced-order ESO. In addition, performance analysis and comparisons between ESO and reduced-order ESO are examined. Nonlinear tracking differentiator is employed to construct the derivative of virtual control command in the control loop. Third, the closed-loop stability for the considered system is established. Finally, the effectiveness of the proposed IGC law in enhanced interception performance such as smooth interception course, improved robustness against multiple uncertainties as well as reduced control consumption during initial phase are demonstrated through simulations.

  7. MAGE-A1, GAGE and NY-ESO-1 cancer/testis antigen expression during human gonadal development

    DEFF Research Database (Denmark)

    Gjerstorff, Morten F; Kock, Kirsten; Nielsen, Ole;

    2007-01-01

    by single and double immunohistochemical staining. RESULTS: We found that GAGE was expressed in the primordial germ cells of the gonadal primordium, whereas MAGE-A1 and NY-ESO-1 were first detected in germ cells of both testis and ovary after sexual differentiation was initiated. The number of positive germ...

  8. Expression of MAGE-A3, NY-ESO-1, LAGE-1 and PRAME in urothelial carcinoma

    DEFF Research Database (Denmark)

    Andersen, Lars Dyrskjøt; Zieger, K; Kissow Lildal, T;

    2012-01-01

    Background: The potential for cancer-testis (CT) antigens as targets for immunotherapy in cancer patients has been heavily investigated, and currently cancer vaccine trials based on the CT antigens, MAGE-A3 and NY-ESO-1, are being carried out. Methods: We used specific q-RT-PCR assays to analyse...... the expression of the CT genes MAGE-A3, NY-ESO-1 (CTAG1B), LAGE-1 (CTAG2) and PRAME in a panel of bladder tumours from 350 patients with long-term follow-up and detailed treatment information. Results: Overall, 43% of the tumours expressed MAGE-A3, 35% expressed NY-ESO-1, 27% expressed LAGE-1 and 20% expressed...... PRAME. In all, 56% of the tumours expressed at least one of the CT genes analysed. Univariate Cox regression analysis of CT gene expression in non-muscle-invasive tumours showed that expression of MAGE-A3 (P=0.026), LAGE-1 (P=0.001) and NY-ESO-1 (P=0.040) was significantly associated with a shorter...

  9. A monolithic collapse origin for the thin and thick disc structure of the S0 galaxy ESO 243-49

    NARCIS (Netherlands)

    Comerón, S.; Salo, H.; Peletier, R. F.; Mentz, J.

    2016-01-01

    ESO 243-49 is a high-mass (circular velocity vc ≈ 200 km s-1), edge-on S0 galaxy in the Abell 2877 cluster at a distance of ~95 Mpc. To elucidate the origin of the thick disc of this S0 galaxy, we use Multi Unit Spectroscopic Explorer (MUSE) science verification data to study its kinematics and

  10. Design, analysis and testing of the Optical Tube Assemblies for the ESO VLT Four Laser Guide Star Facility

    NARCIS (Netherlands)

    Henselmans, R.; Nijkerk, M.D.; Lemmen, M.H.J.; Rijnveld, N.; Kamphues, F.G.

    2012-01-01

    TNO has developed the Optical Tube Assemblies (OTAs) for the ESO VLT Four Laser Guide Star Facility. The OTAs are Galilean 20x beam expanders, expanding a ∅15 mm input beam (25W, 589 nm CW) to a steerable ∅300 mm output beam. TNO has recently successfully completed acceptance testing of the four uni

  11. Machine-learning-based photometric redshifts for galaxies of the ESO Kilo-Degree Survey data release 2

    NARCIS (Netherlands)

    Cavuoti, S.; Brescia, M.; Tortora, C.; Longo, G.; Napolitano, N. R.; Radovich, M.; Barbera, F. La; Capaccioli, M.; de Jong, J. T. A.; Getman, F.; Grado, A.; Paolillo, M.

    2015-01-01

    We have estimated photometric redshifts (zphot) for more than 1.1 million galaxies of the public European Southern Observatory (ESO) Kilo-Degree Survey (KiDS) data release 2. KiDS is an optical wide-field imaging survey carried out with the Very Large Telescope (VLT) Survey Telescope (VST) and the O

  12. VizieR Online Data Catalog: KiDS-ESO-DR2 multi-band source catalog (de Jong+, 2015)

    NARCIS (Netherlands)

    de Jong, J. T. A.; Verdoes Kleijn, G. A.; Boxhoorn, D. R.; Buddelmeijer, H.; Capaccioli, M.; Getman, F.; Grado, A.; Helmich, E.; Huang, Z.; Irisarri, N.; Kuijken, K.; La Barbera, F.; McFarland, J. P.; Napolitano, N. R.; Radovich, M.; Sikkema, G.; Valentijn, E. A.; Begeman, K. G.; Brescia, M.; Cavuoti, S.; Choi, A.; Cordes, O.-M.; Covone, G.; Dall'Ora, M.; Hildebrandt, H.; Longo, G.; Nakajima, R.; Paolillo, M.; Puddu, E.; Rifatto, A.; Tortora, C.; van Uitert, E.; Buddendiek, A.; Harnois-Deraps, J.; Erben, T.; Eriksen, M. B.; Heymans, C.; Hoekstra, H.; Joachimi, B.; Kitching, T. D.; Klaes, D.; Koopmans, L. V. E.; Koehlinger, F.; Roy, N.; Sifon, C.; Schneider, P.; Sutherland, W. J.; Viola, M.; Vriend, W.-J.

    2017-01-01

    KiDS data releases consist of ~1 square degree tiles that have been successfully observed in all four survey filters (u,g,r,i). The second data release (KiDS-ESO-DR2) was available in February 2015 and contains imaging data, masks and single-band source lists for all tiles observed in all four filte

  13. Prácticas, representaciones y discursos de corporalidad. La ambigüedad en los cuerpos circenses

    Directory of Open Access Journals (Sweden)

    Julieta Infantino

    2010-07-01

    Full Text Available En este artículo trabajaremos con las prácticas de los artistas circenses contemporáneos en la ciudad de Buenos Aires. Abordaremos los modos en los que la corporalidad se constituye en uno de los medios de expresión identitaria en tanto un grupo social puede componer, a través de sus experiencias corporales, sus propios estilos artísticos, su propia definición de práctica artístico-laboral, su propio cuerpo legítimo. Mostraremos la manera en que esos cuerpos pueden por momentos disputar y/o reproducir concepciones hegemónicas de corporalidad, proponiendo la necesidad de pensar estos procesos de manera dinámica, prestando atención tanto a los mecanismos de poder como a su contraparte, los sujetos que negocian, cuestionan y/o resisten.

  14. Cancer-testis antigens PRAME and NY-ESO-1 correlate with tumour grade and poor prognosis in myxoid liposarcoma.

    Science.gov (United States)

    Iura, Kunio; Kohashi, Kenichi; Hotokebuchi, Yuka; Ishii, Takeaki; Maekawa, Akira; Yamada, Yuichi; Yamamoto, Hidetaka; Iwamoto, Yukihide; Oda, Yoshinao

    2015-07-01

    Myxoid liposarcoma is the second most common liposarcoma. Although myxoid liposarcoma is relatively chemosensitive and thus a good candidate for chemotherapy, cases with relapsed or metastatic disease still have poor outcome. Here, we performed a gene microarray analysis to compare the gene expression profiles in six clinical myxoid liposarcoma samples and three normal adipose tissue samples, and to identify molecular biomarkers that would be useful as diagnostic markers or treatment targets in myxoid liposarcoma. This showed that the cancer-testis antigen PRAME was up-regulated in myxoid liposarcoma. We then performed immunohistochemical, western blotting and real-time polymerase chain reaction analyses to quantify the expression of PRAME and another cancer-testis antigen, NY-ESO-1, in clinical samples of myxoid liposarcoma (n = 93), dedifferentiated (n = 46), well-differentiated (n = 32) and pleomorphic liposarcomas (n = 14). Immunohistochemically, positivity for PRAME and NY-ESO-1 was observed in 84/93 (90%) and 83/93 (89%) of the myxoid liposarcomas, and in 20/46 (43%) and 3/46 (7%) of the dedifferentiated, 3/32 (9%) and 1/32 (3%) of the well-differentiated and 7/14 (50%) and 3/21 (21%) of the pleomorphic liposarcomas, respectively. High immunohistochemical expression of PRAME and/or NY-ESO-1 was significantly correlated with tumour diameter, the existence of tumour necrosis, a round-cell component of >5%, higher histological grade and advanced clinical stage. High PRAME and NY-ESO-1 expression correlated significantly with poor prognosis in a univariate analysis. The myxoid liposarcomas showed significantly higher protein and mRNA expression levels of PRAME and NY-ESO-1 (CTAG1B) than the other liposarcomas. In conclusion, PRAME and NY-ESO-1 (CTAG1B) were expressed in the vast majority of myxoid liposarcomas, and their high-level expression correlated with tumour grade and poor prognosis. Our results support the potential use of PRAME and NY-ESO

  15. Comprehensive adipocytic and neurogenic tissue microarray analysis of NY-ESO-1 expression - a promising immunotherapy target in malignant peripheral nerve sheath tumor and liposarcoma.

    Science.gov (United States)

    Shurell, Elizabeth; Vergara-Lluri, Maria E; Li, Yunfeng; Crompton, Joseph G; Singh, Arun; Bernthal, Nicholas; Wu, Hong; Eilber, Fritz C; Dry, Sarah M

    2016-11-08

    Immunotherapy targeting cancer-testis antigen NY-ESO-1 shows promise for tumors with poor response to chemoradiation. Malignant peripheral nerve sheath tumors (MPNSTs) and liposarcomas (LPS) are chemoresistant and have few effective treatment options. Materials Methods: Using a comprehensive tissue microarray (TMA) of both benign and malignant tumors in primary, recurrent, and metastatic samples, we examined NY-ESO-1 expression in peripheral nerve sheath tumor (PNST) and adipocytic tumors. The PNST TMA included 42 MPNSTs (spontaneous n = 26, NF1-associated n = 16), 35 neurofibromas (spontaneous n = 22, NF-1 associated n = 13), 11 schwannomas, and 18 normal nerves. The LPS TMA included 48 well-differentiated/dedifferentiated (WD/DD) LPS, 13 myxoid/round cell LPS, 3 pleomorphic LPS, 8 lipomas, 1 myelolipoma, and 3 normal adipocytic tissue samples. Stained in triplicate, NY-ESO-1 intensity and density were scored. NY-ESO-1 expression was exclusive to malignant tumors. 100% of myxoid/round cell LPS demonstrated NY-ESO-1 expression, while only 6% of WD/DD LPS showed protein expression, one of which was WD LPS. Of MPNST, 4/26 (15%) spontaneous and 2/16 (12%) NF1-associated MPNSTs demonstrated NY-ESO-1 expression. Strong NY-ESO-1 expression was observed in myxoid/round cell and dedifferentiated LPS, and MPNST in primary, neoadjuvant, and metastatic settings. We found higher prevalence of NY-ESO-1 expression in MPNSTs than previously reported, highlighting a subset of MPNST patients who may benefit from immunotherapy. This study expands our understanding of NY-ESO-1 in WD/DD LPS and is the first demonstration of staining in a WD LPS and metastatic/recurrent myxoid/round cell LPS. These results suggest immunotherapy targeting NY-ESO-1 may benefit patients with aggressive tumors resistant to conventional therapy.

  16. Treatment with 5-Aza-2'-Deoxycytidine Induces Expression of NY-ESO-1 and Facilitates Cytotoxic T Lymphocyte-Mediated Tumor Cell Killing.

    Science.gov (United States)

    Klar, Agnes S; Gopinadh, Jakka; Kleber, Sascha; Wadle, Andreas; Renner, Christoph

    2015-01-01

    NY-ESO-1 belongs to the cancer/testis antigen (CTA) family and represents an attractive target for cancer immunotherapy. Its expression is induced in a variety of solid tumors via DNA demethylation of the promoter of CpG islands. However, NY-ESO-1 expression is usually very low or absent in some tumors such as breast cancer or multiple myeloma. Therefore, we established an optimized in vitro treatment protocol for up-regulation of NY-ESO-1 expression by tumor cells using the hypomethylating agent 5-aza-2'-deoxycytidine (DAC). We demonstrated de novo induction of NY-ESO-1 in MCF7 breast cancer cells and significantly increased expression in U266 multiple myeloma cells. This effect was time- and dose-dependent with the highest expression of NY-ESO-1 mRNA achieved by the incubation of 10 μM DAC for 72 hours. NY-ESO-1 activation was also confirmed at the protein level as shown by Western blot, flow cytometry, and immunofluorescence staining. The detection and quantification of single NY-ESO-1 peptides presented at the tumor cell surface in the context of HLA-A*0201 molecules revealed an increase of 100% and 50% for MCF7 and U266 cells, respectively. Moreover, the enhanced expression of NY-ESO-1 derived peptides at the cell surface was accompanied by an increased specific lysis of MCF7 and U266 cells by HLA-A*0201/NY-ESO-1(157-165) peptide specific chimeric antigen receptor (CAR) CD8+ T cells. In addition, the killing activity of CAR T cells correlated with the secretion of higher IFN-gamma levels. These results indicate that NY-ESO-1 directed immunotherapy with specific CAR T cells might benefit from concomitant DAC treatment.

  17. Treatment with 5-Aza-2'-Deoxycytidine Induces Expression of NY-ESO-1 and Facilitates Cytotoxic T Lymphocyte-Mediated Tumor Cell Killing.

    Directory of Open Access Journals (Sweden)

    Agnes S Klar

    Full Text Available NY-ESO-1 belongs to the cancer/testis antigen (CTA family and represents an attractive target for cancer immunotherapy. Its expression is induced in a variety of solid tumors via DNA demethylation of the promoter of CpG islands. However, NY-ESO-1 expression is usually very low or absent in some tumors such as breast cancer or multiple myeloma. Therefore, we established an optimized in vitro treatment protocol for up-regulation of NY-ESO-1 expression by tumor cells using the hypomethylating agent 5-aza-2'-deoxycytidine (DAC.We demonstrated de novo induction of NY-ESO-1 in MCF7 breast cancer cells and significantly increased expression in U266 multiple myeloma cells. This effect was time- and dose-dependent with the highest expression of NY-ESO-1 mRNA achieved by the incubation of 10 μM DAC for 72 hours. NY-ESO-1 activation was also confirmed at the protein level as shown by Western blot, flow cytometry, and immunofluorescence staining. The detection and quantification of single NY-ESO-1 peptides presented at the tumor cell surface in the context of HLA-A*0201 molecules revealed an increase of 100% and 50% for MCF7 and U266 cells, respectively. Moreover, the enhanced expression of NY-ESO-1 derived peptides at the cell surface was accompanied by an increased specific lysis of MCF7 and U266 cells by HLA-A*0201/NY-ESO-1(157-165 peptide specific chimeric antigen receptor (CAR CD8+ T cells. In addition, the killing activity of CAR T cells correlated with the secretion of higher IFN-gamma levels.These results indicate that NY-ESO-1 directed immunotherapy with specific CAR T cells might benefit from concomitant DAC treatment.

  18. Prügi, mis polegi prügi

    Index Scriptorium Estoniae

    2007-01-01

    2007. a. oktoobris oli Tallinna Botaanikaaias avatud jäätmete temaatikale pühendatud näitus, mis valmis koostöös Uuskasutuskeskuse ja Tallinna Loomaaiaga. Avatud oli soome fotograafi Timo Vartiaise ning maastikuarhitekti Henrik Jenseni fotonäitus "Prügimägi, mu arm"

  19. Immunoediting and persistence of antigen-specific immunity in patients who have previously been vaccinated with NY-ESO-1 protein formulated in ISCOMATRIX™.

    Science.gov (United States)

    Nicholaou, Theo; Chen, Weisan; Davis, Ian D; Jackson, Heather M; Dimopoulos, Nektaria; Barrow, Catherine; Browning, Judy; Macgregor, Duncan; Williams, David; Hopkins, Wendie; Maraskovsky, Eugene; Venhaus, Ralph; Pan, Linda; Hoffman, Eric W; Old, Lloyd J; Cebon, Jonathan

    2011-11-01

    NY-ESO-1 protein formulated in ISCOMATRIX™ results in CD4+, CD8+ T cell and antibody-mediated immunity. We evaluated persistence of immunity, relapse-free survival and tumour antigen expression upon relapse in patients vaccinated in an earlier trial. Immunity was measured in 28 patients with resected NY-ESO-1-expressing tumours (melanoma 25, breast 3) 252-1,155 days (median = 681) after vaccination. In the earlier vaccination, trial patients received NY-ESO-1 with ISCOMATRIX™ adjuvant at three protein doses 10 μg, 30 μg or 100 μg (n = 14); 100 μg NY-ESO-1 protein (n = 8) or placebo (n = 6), together with 1 μg of intradermal (ID) NY-ESO-1 protein twice for DTH skin testing. Immune responses assessed in the current study included antibody titres, circulating NY-ESO-1-specific T cells and DTH reactivity 2 days after DTH skin testing with NY-ESO-1 protein (1 μg) or peptides (10 μg). Relapse-free survival was determined for 42 melanoma patients. On relapse NY-ESO-1 and HLA, class I was assessed by immunohistochemistry in 17. Persisting anti-NY-ESO-1 immunity was detected in 10/14 recipients who had previously received vaccine with ISCOMATRIX™ adjuvant. In contrast, immunity only persisted in 3/14 who received 100 μg un-adjuvanted NY-ESO-1 protein (3/8) or 2 μg DTH protein (0/6) P = 0.02. Hence, persisting NY-ESO-1 immunity was associated with prior adjuvant. Tumour NY-ESO-1 or HLA class I was downregulated in participants who relapsed suggesting immunoediting had occurred. Immunoediting suggests that a signal of anti-tumour activity was observed in high-risk resected melanoma patients vaccinated with NY-ESO-1/ISCOMATRIX™. This was associated with measurable persisting immunity in the majority of vaccinated subjects tested. A prospective randomised trial has been undertaken to confirm these results.

  20. Evaluating Your School PR Investment.

    Science.gov (United States)

    Bagin, Rich

    Educational public relations (PR) is a planned and systematic management function designed to help improve the programs and services of an educational organization. The standards and techniques discussed in this guide are based on the nearly 50 years of experience of the National School Public Relations Association (NSPRA). The guidebook offers…

  1. Spectroscopic study of the elusive globular cluster ESO452-SC11 and its surroundings

    Science.gov (United States)

    Koch, Andreas; Hansen, Camilla Juul; Kunder, Andrea

    2017-08-01

    Globular clusters (GCs) have long been recognized as being amongst the oldest objects in the Galaxy. As such, they have the potential of playing a pivotal role in deciphering the Milky Way's early history. Here we present the first spectroscopic study of the low-mass system ESO452-SC11 using the AAOmega multifibre spectrograph at medium resolution. Given the stellar sparsity of this object and the high degree of foreground contamination due to its location toward the Galactic bulge, very few details are known for this cluster - there is no consensus, for instance, about its age, metallicity, or its association with the disk or bulge. We identify five member candidates based on common radial velocity, calcium-triplet metallicity, and position within the GC. Using spectral synthesis, the measurement of accurate Fe-abundances from Fe-lines, and abundances of several α-, Fe-peak, and neutron-capture elements (Si, Ca, Ti,Cr, Co, Ni, Sr, and Eu) is carried out, albeit with large uncertainties. We find that two of the five cluster candidates are likely non-members, as they have deviating iron abundances and [α/Fe] ratios. The cluster mean heliocentric velocity is 19 ± 2 km s-1 with a velocity dispersion of 2.8 ± 3.4 km s-1, a low value in line with its sparse nature and low mass. The mean Fe-abundance from spectral fitting is -0.88 ± 0.03 dex, where the spread is driven by observational errors. Furthermore, the α-elements of the GC candidates are marginally lower than expected for the bulge at similar metallicities. As spectra of hundreds of stars were collected in a 2-degree field centered on ESO452-SC11, a detailed abundance study of the surrounding field was also enabled. The majority of the non-members have slightly higher [α/Fe] ratios, in line with the typical nearby bulge population. A subset of the spectra with measured Fe-peak abundance ratios shows a large scatter around solar values, albeit with large uncertainties. Furthermore, our study provides the

  2. VLT/X-shooter observations of blue compact galaxies Haro 11 and ESO 338-IG 004

    Science.gov (United States)

    Guseva, N. G.; Izotov, Y. I.; Fricke, K. J.; Henkel, C.

    2012-05-01

    Context. Strongly star-forming galaxies of subsolar metallicities are typical of the high-redshift universe. Here we therefore provide accurate data for two low-z analogs, the well-known low-metallicity emission-line galaxies Haro 11 and ESO 338-IG 004. Aims: Our main goal is to derive their spectroscopic properties and to examine whether a previously reported near-infrared (NIR) excess in Haro 11 can be confirmed. Methods: On the basis of Very Large Telescope/X-shooter spectroscopic observations in the wavelength range ~λλ3000-24 000 Å, we use standard direct methods to derive physical conditions and element abundances. Furthermore, we use X-shooter data together with Spitzer observations in the mid-infrared range to attempt to find hidden star formation. Results: We derive interstellar oxygen abundances of 12 + log O/H = 8.33 ± 0.01, 8.10 ± 0.04, and 7.89 ± 0.01 in the two H ii regions B and C of Haro 11 and in ESO 338-IG 004, respectively. The observed fluxes of the hydrogen lines correspond to the theoretical recombination values after correction for extinction with a single value of the extinction coefficient C(Hβ) across the entire wavelength range from the near-ultraviolet to the NIR and mid-infrared for each of the studied H ii regions. Thus, we confirm our previous findings obtained for several low-metallicity emission-line galaxies (Mrk 59, II Zw 40, Mrk 71, Mrk 996, SBS 0335-052E, PHL 293B, and GRB HG 031203) that the extinction coefficient C(Hβ) is not higher in the NIR than in the optical range and therefore that there are no emission-line regions contributing to the line emission in the NIR range, which are hidden in the optical range. The agreement between the extinction-corrected and CLOUDY-predicted fluxes implies that a H ii region model including only stellar photoionisation is able to account for the observed fluxes, in both the optical and NIR ranges. No additional excitation mechanism such as shocks from stellar winds and supernova

  3. Prôtegis data

    Directory of Open Access Journals (Sweden)

    María Fernanda De la Ossa Archila

    2013-12-01

    Full Text Available El suministro de datos personales por los particulares se realiza casi a diario, por lo que es básico conocer quién tiene esos datos, cuáles son las medidas que adopta este sujeto para que dichos datos sean utilizados de manera correcta y para unos fines precisos para los cuales se han suministrado. La pregunta concreta que debe uno formularse es cómo se protegen los datos personales. Teniendo en cuenta lo anterior, en este artículo se hará un recuento de lo que ocurre en el contexto colombiano, en donde el legislador, por medio de la Ley 1581 de 2012 que fue sometida a control previo de constitucionalidad, reguló los derechos de los titulares de la información, los deberes de los responsables y encargados del tratamiento de la información suministrada y señaló de manera concreta cuál es la autoridad encargada para la vigilancia y control de una efectiva protección de los datos personales.

  4. Fine-mapping naturally occurring NY-ESO-1 antibody epitopes in melanoma patients' sera using short overlapping peptides and full-length recombinant protein.

    Science.gov (United States)

    Komatsu, Nobukazu; Jackson, Heather M; Chan, Kok-fei; Oveissi, Sara; Cebon, Jonathan; Itoh, Kyogo; Chen, Weisan

    2013-07-01

    The tumor antigen NY-ESO-1 is one of the most antigenic cancer-testis antigens, first identified by serologic analysis of a recombinant cDNA expression library (SEREX). NY-ESO-1 is expressed in different types of cancers including melanoma. NY-ESO-1-specific spontaneous humoral and cellular immune responses are detected in a large proportion of patients with advanced NY-ESO-1-expressing cancers. Therefore NY-ESO-1 is a good candidate antigen for immunotherapy. Although cellular immune responses to NY-ESO-1 are well characterized, much less is known about the humoral immune responses. In this study, we finely mapped linear antibody epitopes using sera from melanoma patients and shorter overlapping peptide sets. We have shown that melanoma patients' humoral immune systems responded to NY-ESO-1 differently in each individual with widely differing antibody specificity, intensity and antibody subtypes. This knowledge will help us further understand anti-tumor immunity and may also help us to monitor cancer progress and cancer vaccine efficacy in the future. Copyright © 2013 Elsevier Ltd. All rights reserved.

  5. RT—PCR检测胃癌NY—ESO-1抗原的表达及其基因克隆

    Institute of Scientific and Technical Information of China (English)

    黄梅花; 刘磊; 欧阳永忠

    2005-01-01

    目的:研究NY—ESO-1基因在胃癌中的表达,以便了解为胃癌患者是否可以使用NY—ESO-1抗原为基础的疫苗治疗。方法:采用RT—PCR方法检测了NY—ESO-1基因在60例胃癌组织和相应的癌旁正常组织中的表达,采用分子克隆的方法从胃癌组织中克隆了NY-ESO—1cDNA。结果MY—ESO-1基因在胃癌组织中的表达率为55%(33/60),在相应的癌旁正常组织中的未见表达,克隆的NY—ESO-1cDNA序列与GenBank报道一致。结论-NY—ESO-1基因在胃癌中的高表达率,NY—ESO-1抗原可以被具有HLA-1类分子限制性CTL识别。

  6. The cancer-testis antigen NY-ESO-1 is highly expressed in myxoid and round cell subset of liposarcomas.

    Science.gov (United States)

    Hemminger, Jessica A; Ewart Toland, Amanda; Scharschmidt, Thomas J; Mayerson, Joel L; Kraybill, William G; Guttridge, Denis C; Iwenofu, O Hans

    2013-02-01

    Liposarcomas are a heterogenous group of fat-derived sarcomas, and surgery with or without chemoradiation therapy remains the main stay of treatment. NY-ESO-1 is a cancer-testis antigen expressed in various cancers where it can induce both cellular and humoral immunity. Immunotherapy has shown promise in clinical trials involving NY-ESO-1-expressing tumors. Gene expression studies have shown upregulation of the gene for NY-ESO-1, CTAG1B, in myxoid and round cell liposarcomas. Herein, we evaluated the expression of NY-ESO-1 among liposarcoma subtypes by quantitative real-time PCR, western blot analysis, and immunohistochemistry. Frozen tissue for quantitative real-time PCR and western blot analysis was obtained for the following liposarcoma subtypes (n=15): myxoid and round cell (n=8); well-differentiated (n=4), and dedifferentiated (n=3). Formalin-fixed paraffin-embedded blocks were obtained for the following liposarcoma subtypes (n=44): myxoid and round cell (n=18); well-differentiated (n=10); dedifferentiated (n=10); and pleomorphic (n=6). Full sections were stained with monoclonal antibody NY-ESO-1, and staining was assessed for intensity (1-3+), percentage of tumor positivity, and location. In all, 7/8 (88%) and 16/18 (89%) myxoid and round cell expressed CTAG1B and NY-ESO-1 by quantitative real-time PCR and immunohistochemistry, respectively. Western blot correlated with mRNA expression levels. By immunohistochemistry, 94% (15/16) of positive cases stained homogenously with 2-3+ intensity. Also, 3/6 (50%) pleomorphic liposarcomas demonstrated a range of staining: 1+ intensity in 50% of cells; 2+ intensity in 5% of cells; and 3+ intensity in 90% of cells. One case of dedifferentiated liposarcoma showed strong, diffuse staining (3+ intensity in 75% of cells). Our study shows that both CTAG1B mRNA and protein are overexpressed with high frequency in myxoid and round cell liposarcoma, enabling the potential use of targeted immunotherapy in the treatment of this

  7. Immunization of HLA-A*0201 and/or HLA-DPβ1*04 Patients with Metastatic Melanoma Using Epitopes from the NY-ESO-1 Antigen

    Science.gov (United States)

    Khong, Hung T.; Yang, James C.; Topalian, Suzanne L.; Sherry, Richard M.; Mavroukakis, Sharon A.; White, Donald E.; Rosenberg, Steven A.

    2008-01-01

    HLA class I-restricted peptides are often used in peptide vaccine regimens. There is strong evidence that many of these peptides can generate specific CD8+ T-cell responses in vivo; however, only occasional objective clinical responses have been reported. To test whether provision of “help” would enhance antitumor immunity, the authors initiated a clinical trial in which patients with metastatic melanoma were immunized against the NY-ESO-1 tumor antigen, using an HLA-A2-restricted peptide (ESO-1:165V), an HLA-DP4-restricted peptide (NY-ESO-1:161-180), or both peptides given concomitantly. The first cohorts received only ESO-1:165V, using three vaccination schedules. Immunologically, most patients developed immune responses to the HLA-A2-restricted native ESO-1 epitope after vaccination. Peptide vaccine given daily for 4 days appeared to induce immunologic responses more rapidly than if given once a week or once every 3 weeks. In contrast, vaccination using the NY-ESO-1:161-180 peptide induced immune responses in only a few patients. Clinically, one patient who received NY-ESO-1:161-180 peptide alone had a partial response lasing 12 months. Concomitant vaccination with the HLA class II-restricted peptide did not alter the immune response to the HLA class I-restricted peptide form NY-ESO-1. However, vaccination with the HLA-A2-restricted epitope generated primarily T cells that did not recognize tumor after in vitro sensitization. This result raises questions about the use of synthetic peptides derived from NY-ESO-1 as a sole form of immunization. PMID:15534491

  8. The Gaia-ESO Survey: Separating disk chemical substructures with cluster models

    CERN Document Server

    Rojas-Arriagada, A; de Laverny, P; Schultheis, M; Guiglion, G; Mikolaitis, Š; Kordopatis, G; Hill, V; Gilmore, G; Randich, S; Alfaro, E J; Bensby, T; Koposov, S E; Costado, M T; Franciosini, E; Hourihane, A; Jofré, P; Lardo, C; Lewis, J; Lind, K; Magrini, L; Monaco, L; Morbidelli, L; Sacco, G G; Worley, C C; Zaggia, S; Chiappini, C

    2015-01-01

    (Abridged) Recent spectroscopic surveys have begun to explore the Galactic disk system outside the solar neighborhood on the basis of large data samples. In this way, they provide valuable information for testing spatial and temporal variations of disk structure kinematics and chemical evolution. We used a Gaussian mixture model algorithm, as a rigurous mathematical approach, to separate in the [Mg/Fe] vs. [Fe/H] plane a clean disk star subsample from the Gaia-ESO survey internal data release 2. We find that the sample is separated into five groups associated with major Galactic components; the metal-rich end of the halo, the thick disk, and three subgroups for the thin disk sequence. This is confirmed with a sample of red clump stars from the Apache Point Observatory Galactic Evolution Experiment (APOGEE) survey. The two metal-intermediate and metal-rich groups of the thin disk decomposition ([Fe/H]>-0.25 dex) highlight a change in the slope at solar metallicity. This holds true at different radial regions. ...

  9. The Gaia-ESO Survey: Detailed Abundances in the Metal-poor Globular Cluster NGC 4372

    CERN Document Server

    Roman, I San; Geisler, D; Villanova, S; Kacharov, N; Koch, A; Carraro, G; Tautvaišiene, G; Vallenari, A; Alfaro, E J; Bensby, T; Flaccomio, E; Francois, P; Korn, A J; Pancino, E; Recio-Blanco, A; Smiljanic, R; Bergemann, M; Costado, M T; Damiani, F; Heiter, U; Hourihane, A; Jofré, P; Lardo, C; de Laverny, P; Masseron, T; Morbidelli, L; Sbordone, L; Sousa, S G; Worley, C C; Zaggia, S

    2015-01-01

    We present the abundance analysis for a sample of 7 red giant branch stars in the metal-poor globular cluster NGC 4372 based on UVES spectra acquired as part of the Gaia-ESO Survey. This is the first extensive study of this cluster from high resolution spectroscopy. We derive abundances of O, Na, Mg, Al, Si, Ca, Sc, Ti, Fe, Cr, Ni, Y, Ba, and La. We find a metallicity of [Fe/H] = -2.19 $\\pm$ 0.03 and find no evidence for a metallicity spread. This metallicity makes NGC 4372 one of the most metal-poor galactic globular clusters. We also find an {\\alpha}-enhancement typical of halo globular clusters at this metallicity. Significant spreads are observed in the abundances of light elements. In particular we find a Na-O anti-correlation. Abundances of O are relatively high compared with other globular clusters. This could indicate that NGC 4372 was formed in an environment with high O for its metallicity. A Mg-Al spread is also present which spans a range of more than 0.5 dex in Al abundances. Na is correlated wit...

  10. The Gaia-ESO survey: Metal-rich bananas in the bulge

    CERN Document Server

    Williams, Angus A; Molloy, Matthew; Kordopatis, Georges; Smith, M C; Shen, J; Gilmore, G; Randich, S; Bensby, T; Francois, P; Koposov, S E; Recio-Blanco, A; Bayo, A; Carraro, G; Casey, A; Costado, T; Franciosini, E; Hourihane, A; de Laverny, P; Lewis, J; Lind, K; Magrini, L; Monaco, L; Morbidelli, L; Sacco, G G; Worley, C; Zaggia, S; Mikolaitis, S

    2016-01-01

    We analyse the kinematics of $\\sim 2000$ giant stars in the direction of the Galactic bulge, extracted from the Gaia-ESO survey in the region $-10^\\circ \\lesssim \\ell \\lesssim 10^\\circ$ and $-11^\\circ \\lesssim b \\lesssim -3^\\circ$. We find distinct kinematic trends in the metal rich ($\\mathrm{[M/H]}>0$) and metal poor ($\\mathrm{[M/H]}<0$) stars in the data. The velocity dispersion of the metal-rich stars drops steeply with latitude, compared to a flat profile in the metal-poor stars, as has been seen previously. We argue that the metal-rich stars in this region are mostly on orbits that support the boxy-peanut shape of the bulge, which naturally explains the drop in their velocity dispersion profile with latitude. The metal rich stars also exhibit peaky features in their line-of-sight velocity histograms, particularly along the minor axis of the bulge. We propose that these features are due to stars on resonant orbits supporting the boxy-peanut bulge. This conjecture is strengthened through the comparison ...

  11. The Gaia-ESO Survey: membership and Initial Mass Function of the Gamma Velorum cluster

    CERN Document Server

    Prisinzano, L; Micela, G; Jeffries, R D; Franciosini, E; Sacco, G G; Frasca, A; Klutsch, A; Lanzafame, A; Alfaro, E J; Biazzo, K; Bonito, R; Bragaglia, A; Caramazza, M; Vallenari, A; Carraro, G; Costado, M T; Flaccomio, E; Jofre', P; Lardo, C; Monaco, L; Morbidelli, L; Mowlavi, N; Pancino, E; Randich, S; Zaggia, S

    2016-01-01

    Understanding the properties of young open clusters, such as the Initial Mass Function (IMF), star formation history and dynamic evolution, is crucial to obtain reliable theoretical predictions of the mechanisms involved in the star formation process. We want to obtain a list, as complete as possible, of confirmed members of the young open cluster Gamma Velorum, with the aim of deriving general cluster properties such as the IMF. We used all available spectroscopic membership indicators within the Gaia-ESO public archive together with literature photometry and X-ray data and, for each method, we derived the most complete list of candidate cluster members. Then, we considered photometry, gravity and radial velocities as necessary conditions to select a subsample of candidates whose membership was confirmed by using the lithium and H$\\alpha$ lines and X-rays as youth indicators. We found 242 confirmed and 4 possible cluster members for which we derived masses using very recent stellar evolutionary models. The c...

  12. The Gaia-ESO Survey: Kinematic structure in the Gamma Velorum Cluster

    CERN Document Server

    Jeffries, R D; Cottaar, M; Koposov, S E; Lanzafame, A C; Meyer, M R; Prisinzano, L; Randich, S; Sacco, G G; Brugaletta, E; Caramazza, M; Damiani, F; Franciosini, E; Frasca, A; Gilmore, G; Feltzing, S; Micela, G; Alfaro, E; Bensby, T; Pancino, E; Recio-Blanco, A; de Laverny, P; Lewis, J; Magrini, L; Morbidelli, L; Costado, M T; Jofre, P; Klutsch, A; Lind, K; Maiorca, E

    2014-01-01

    Context: A key science goal of the Gaia-ESO survey (GES) is to use the kinematics of low-mass stars in young clusters to probe their dynamical histories and how they populate the field as they become unbound. The clustering of low-mass stars around the massive W-R binary gamma^2 Velorum was one of the first GES targets. Aims: To empirically determine the radial velocity (RV) precision of GES data, construct a kinematically unbiased sample of cluster members and characterise their dynamical state. Methods: Targets were selected from colour-magnitude diagrams and intermediate resolution spectroscopy used to derive RVs and assess membership from the strength of the Li6708A line. The RV distribution was analysed using a maximum likelihood technique that accounts for unresolved binaries. Results: The GES RV precision is about 0.25km/s and sufficient to resolve velocity structure in the low-mass population around gamma^2 Vel. The structure is well fitted by two kinematic components with roughly equal numbers of sta...

  13. The Gaia-ESO Survey: Dynamical Analysis of the L1688 region in Ophiuchus

    CERN Document Server

    Rigliaco, Elisabetta; Meyer, M R; Jeffries, R D; Cottaar, M; Frasca, A; Wright, N J; Bayo, A; Bonito, R; Damiani, F; Jackson, R J; Jiménez-Esteban, F; Kalari, V M; Klutsch, A; Lanzafame, A C; Sacco, G; Gilmore, G; Randich, S; Alfaro, E J; Bragaglia, A; Costado, M T; Franciosini, E; Lardo, C; Monaco, L; Morbidelli, L; Prisinzano, L; Sousa, S G; Zaggia, S

    2016-01-01

    The Gaia ESO Public Spectroscopic Survey (GES) is providing the astronomical community with high-precision measurements of many stellar parameters including radial velocities (RVs) of stars belonging to several young clusters and star-forming regions. One of the main goals of the young cluster observations is to study of their dynamical evolution and provide insight into their future, revealing if they will eventually disperse to populate the field, rather than evolve into bound open clusters. In this paper we report the analysis of the dynamical state of L1688 in the $\\rho$~Ophiuchi molecular cloud using the dataset provided by the GES consortium. We performed the membership selection of the more than 300 objects observed. Using the presence of the lithium absorption and the location in the Hertzspung-Russell diagram, we identify 45 already known members and two new association members. We provide accurate RVs for all 47 confirmed members.A dynamical analysis, after accounting for unresolved binaries and err...

  14. The Gaia-ESO Survey: the Galactic Thick to Thin Disc transition

    CERN Document Server

    Recio-Blanco, A; Kordopatis, G; Helmi, A; Hill, V; Gilmore, G; Wyse, R; Adibekyan, V; Randich, S; Asplund, M; Feltzing, S; Jeffries, R; Micela, G; Vallenari, A; Alfaro, E; Prieto, C Allende; Bensby, T; Bragaglia, A; Flaccomio, E; Koposov, S E; Korn, A; Lanzafame, A; Pancino, E; Smiljanic, R; Jackson, R; Lewis, J; Magrini, L; Morbidelli, L; Prinsinzano, L; Sacco, G; Worley, C C; Hourihane, A; Bergemann, M; Costado, M T; Heiter, U; Joffre, P; Lardo, C; Lind, K; Maiorca, E

    2014-01-01

    (Abridged) We have used the atmospheric parameters, [alpha/Fe] abundances and radial velocities, determined from the Gaia-ESO Survey GIRAFFE spectra of FGK-type stars (iDR1), to provide a chemo-kinematical characterisation of the disc stellar populations. We focuss on a subsample of 1016 stars with high quality parameters, covering the volume |Z|<4.5kpc and R in the range 2-13kpc. We have identified a thin to thick disc separation in the [alpha/Fe] vs [M/H] plane, thanks to the presence of a low-density region in the number density distribution. The thick disc stars seem to lie in progressively thinner layers above the Galactic plane, as metallicity increases and [alpha/Fe] decreases. The thin disc population presents a constant value of the mean distance to the plane at all metallicities. Our data confirm the already known correlations between V_phi and [M/H] for the two discs. For the thick disc sequence, a study of the possible contamination by thin disc stars suggests a gradient up to 64km/s/dex. The d...

  15. The Gaia-ESO Survey: A lithium-rotation connection at 5 Myr?

    CERN Document Server

    Bouvier, J; Venuti, L; Klutsch, A; Jeffries, R; Frasca, A; Moraux, E; Biazzo, K; Messina, S; Micela, G; Randich, S; Stauffer, J; Cody, A M; Flaccomio, E; Gilmore, G; Bayo, A; Bensby, T; Bragaglia, A; Carraro, C; Casey, A; Costado, M T; Damiani, F; Mena, E Delgado; Donati, P; Franciosini, E; Hourihane, A; Koposov, S; Lardo, C; Lewis, J; Magrini, L; Monaco, L; Morbidelli, L; Prisinzano, L; Sacco, G; Sbordone, L; Sousa, S G; Vallenari, A; Worley, C C; Zaggia, S; Zwitter, T

    2016-01-01

    We investigate here the lithium content of young low-mass stars in the 5~Myr-old star forming region NGC~2264 and its relationship with rotation. We combine lithium equivalent width measurements, EW(Li), from the Gaia-ESO Survey with the determination of rotational periods from the CSI~2264 survey. We consider only bona fide non accreting cluster members in order to minimize uncertainties on EW(Li). We report the existence of a relationship between lithium content and rotation in NGC~2264 at an age of 5~Myr. The Li-rotation connection is seen over a restricted temperature range, Teff=3800--4400K, where fast rotators are Li-rich compared to slow ones. This correlation is similar to, albeit of lower amplitude than, the Li-rotation connection previously reported for K dwarfs in the 125 Myr-old Pleiades cluster. We investigate whether the non-standard pre-main sequence models developed so far to explain the Pleiades results, which are based on episodic accretion, pre-main sequence core-envelope decoupling, and/or...

  16. The Gaia-ESO Survey: metallicity and kinematic trends in the Milky Way bulge

    CERN Document Server

    Rojas-Arriagada, A; Hill, V; de Laverny, P; Schultheis, M; Babusiaux, C; Zoccali, M; Minniti, D; Gonzalez, O A; Feltzing, S; Gilmore, G; Randich, S; Vallenari, A; Alfaro, E J; Bensby, T; Bragaglia, A; Flaccomio, E; Lanzafame, A C; Pancino, E; Smiljanic, R; Bergemann, M; Costado, M T; Damiani, F; Hourihane, A; Jofré, P; Lardo, C; Magrini, L; Maiorca, E; Morbidelli, L; Sbordone, L; Worley, C C; Zaggia, S; Wyse, R

    2014-01-01

    (Abridged) We analyzed the stellar parameters and radial velocities of ~1200 stars in five bulge fields as determined from the Gaia-ESO survey data (iDR1). We use VISTA Variables in The Via Lactea (VVV) photometry to obtain reddening values by using a semi-empirical T_eff-color calibration. From a Gaussian decomposition of the metallicity distribution functions, we unveil a clear bimodality in all fields, with the relative size of components depending of the specific position on the sky. In agreement with some previous studies, we find a mild gradient along the minor axis (-0.05 dex/deg between b=-6 and b=-10) that arises from the varying proportion of metal-rich and metal-poor components. The number of metal-rich stars fades in favor of the metal-poor stars with increasing b. The K-magnitude distribution of the metal-rich population splits into two peaks for two of the analyzed fields that intersects the near and far branches of the X-shaped bulge structure. In addition, two lateral fields at (l,b)=(7,-9) an...

  17. The Gaia-ESO Survey: revisiting the Li-rich giant problem

    Science.gov (United States)

    Casey, A. R.; Ruchti, G.; Masseron, T.; Randich, S.; Gilmore, G.; Lind, K.; Kennedy, G. M.; Koposov, S. E.; Hourihane, A.; Franciosini, E.; Lewis, J. R.; Magrini, L.; Morbidelli, L.; Sacco, G. G.; Worley, C. C.; Feltzing, S.; Jeffries, R. D.; Vallenari, A.; Bensby, T.; Bragaglia, A.; Flaccomio, E.; Francois, P.; Korn, A. J.; Lanzafame, A.; Pancino, E.; Recio-Blanco, A.; Smiljanic, R.; Carraro, G.; Costado, M. T.; Damiani, F.; Donati, P.; Frasca, A.; Jofré, P.; Lardo, C.; de Laverny, P.; Monaco, L.; Prisinzano, L.; Sbordone, L.; Sousa, S. G.; Tautvaišienė, G.; Zaggia, S.; Zwitter, T.; Delgado Mena, E.; Chorniy, Y.; Martell, S. L.; Silva Aguirre, V.; Miglio, A.; Chiappini, C.; Montalban, J.; Morel, T.; Valentini, M.

    2016-09-01

    The discovery of lithium-rich giants contradicts expectations from canonical stellar evolution. Here we report on the serendipitous discovery of 20 Li-rich giants observed during the Gaia-ESO Survey, which includes the first nine Li-rich giant stars known towards the CoRoT fields. Most of our Li-rich giants have near-solar metallicities and stellar parameters consistent with being before the luminosity bump. This is difficult to reconcile with deep mixing models proposed to explain lithium enrichment, because these models can only operate at later evolutionary stages: at or past the luminosity bump. In an effort to shed light on the Li-rich phenomenon, we highlight recent evidence of the tidal destruction of close-in hot Jupiters at the sub-giant phase. We note that when coupled with models of planet accretion, the observed destruction of hot Jupiters actually predicts the existence of Li-rich giant stars, and suggests that Li-rich stars should be found early on the giant branch and occur more frequently with increasing metallicity. A comprehensive review of all known Li-rich giant stars reveals that this scenario is consistent with the data. However, more evolved or metal-poor stars are less likely to host close-in giant planets, implying that their Li-rich origin requires an alternative explanation, likely related to mixing scenarios rather than external phenomena.

  18. ESO adaptive optics NGSD/LGSD detector and camera controller for the E-ELT

    Science.gov (United States)

    Reyes-Moreno, Javier; Downing, Mark; Di Lieto, Nicola

    2016-07-01

    This paper presents the development of the ESO prototype detector controller for the Adaptive Optics imager on the E-ELT which is based on the e2v Natural Guide Star Detector (NGSD) and Laser Guide Star Detector (LGSD). Both NGSD and LGSD are prototype detectors aiming at proving the CMOS technology in the context of the requirement for a Large Visible AO WFS Detector for the E-ELT. NGSD is a custom design CMOS array detector of 880×840 pixels organized as 44×42 sub-apertures of 20×20 pixel each. NGSD is exactly 1/4 of the LGSD and therefore it is considered a scaled down demonstrator for the LGSD. The detector controller requirements present important challenges in the design of the electronics due to the low-power, low-noise and high parallel data rate of the detectors involved. The general architecture of the controller, the front-end electronics to drive and read-out the detector along with the camera design are described here. This electronics is based on advanced Xilinx FPGAs.

  19. Final binary star results from the ESO VLT Lunar occultations program

    Energy Technology Data Exchange (ETDEWEB)

    Richichi, A. [National Astronomical Research Institute of Thailand, 191 Siriphanich Bldg., Huay Kaew Road, Suthep, Muang, Chiang Mai 50200 (Thailand); Fors, O. [Departament Astronomia i Meteorologia and Institut de Ciències del Cosmos (ICC), Universitat de Barcelona (UB/IEEC), Martí i Franqués 1, E-08028 Barcelona (Spain); Cusano, F. [INAF-Osservatorio Astronomico di Bologna, Via Ranzani 1, I-40127 Bologna (Italy); Ivanov, V. D., E-mail: andrea4work@gmail.com [European Southern Observatory, Ave. Alonso de Cordova 3107, Casilla 19001, Santiago 19 (Chile)

    2014-03-01

    We report on 13 subarcsecond binaries, detected by means of lunar occultations in the near-infrared at the ESO Very Large Telescope (VLT). They are all first-time detections except for the visual binary HD 158122, which we resolved for the first time in the near-infrared. The primaries have magnitudes in the range K = 4.5-10.0, and companions in the range K = 6.8-11.1. The magnitude differences have a median value of 2.4, with the largest being 4.6. The projected separations are in the range of 4-168 mas, with a median of 13 mas. We discuss and compare our results with the available literature. With this paper, we conclude the mining for binary star detections in the 1226 occultations recorded at the VLT with the ISAAC instrument. We expect that the majority of these binaries may be unresolvable by adaptive optics on current telescopes, and they might be challenging for long-baseline interferometry. However, they constitute an interesting sample for future larger telescopes and for astrometric missions such as GAIA.

  20. Detailed studies om three open clusters from Gaia ESO Survey (GES)

    Science.gov (United States)

    Balaguer-Núnez, L.; Casamiquela, L.; Jordana, N.; Massana, P.; Jordi, C.; Masana, E.

    2017-03-01

    We present results for the intermediate-age and old open clusters NGC 6633, NGC 6705 (M 11) and NGC 2682 (M 67). We have used new Str ̈omgren-Crawford photometry, proper motions from ROA observations and spectral information from Gaia-ESO Survey (GES), to study the physical parameters of the stars in the three cluster's areas. The astrometric studies cover an area of about 1°x2° and down to r' ˜ 17 while our INT-WFC CCD intermediate-band photometry covers an area of about 40'x40' down to V ˜ 19. The stars of those areas selected as cluster members from their proper motions, are classified into photometric regions and their physical parameters determined, using uvbyHβ photometry and standard relations among colour indices for each of the photometric regions of the HR diagram. That allows us to determine reddening, distances, absolute magnitudes, spectral types, effective temperatures, gravities and metallicities, thus providing an astrophysical characterization of the clusters. These results are compared with the physical parameters obtained from GES spectral data as well as radial velocities to confirm membership. All these data lead us to a comparison of photometric and spectroscopic physical parameters.

  1. The Gaia-ESO Survey: A simple explanation for the Li-rich giant problem

    CERN Document Server

    Casey, Andrew R; Masseron, T; Randich, S; Gilmore, G; Lind, K; Kennedy, G M; Smiljanic, R; Jofre, P; Hourihane, A; Bragaglia, A; Donati, P; Koposov, S E; Worley, C C; Lanzafame, A; Franciosini, E; Lewis, J R; Magrini, L; Morbidelli, L; Sacco, G G; Bensby, T; Carraro, G; Damiani, F; Feltzing, S; Jeffries, R D; Korn, A J; Lardo, C; de Laverny, P; Mena, E Delgado; Costado, M T; Flaccomio, E; Frasca, A; Monaco, L; Pancino, E; Prisinzano, L; Recio-Blanco, A; Sbordone, L; Sousa, S G; Tautvaisiene, G; Vallenari, A; Zaggia, S; Zwitter, T; Aguirre, V Silva; Chorniy, Y; Martell, S L; Miglo, A; Chiappini, C; Montalban, J; Morel, T; Valentini, M

    2016-01-01

    The discovery of lithium-rich giants contradicts expectations from canonical stellar evolution. Although multiple scenarios have been proposed to preserve or produce Li, no model can explain the ensemble properties of Li-rich giants. We report on the serendipitous discovery of 20 Li-rich giants observed through the Gaia-ESO Survey. Our sample is one of the largest in the literature, and includes nine towards the CoRoT fields. We explore all mechanisms proposed to explain Li-rich giants. While the planet accretion scenario was presented to reconcile observations of Li-rich giants across the RGB/AGB, this is inconsistent with recent studies of close-in giant planets. We highlight recent observations of the difference in hot Jupiter occurrence rates around dwarf and sub-giant stars as evidence for their tidal destruction when the convective envelope expands. Therefore any close-in giant planet is likely to be engulfed well before the host evolves up the RGB/AGB. When this occurs, simulations indicate a giant pla...

  2. CRIRES+ : A Cross-dispersed High-resolution Infrared Spectrograph for ESO's VLT

    Science.gov (United States)

    Hatzes, Artie; CRIRES+ Team

    2017-06-01

    CRIRES+ is a major upgrade to the former CRyogenic high resolution Infra-Red Echelle Spectrograph of ESO's 8.2m Very Large Telescope. The major science drivers for this upgrade are the confirmation and characterization (e.g. determination of the mass) of rocky planets in the so-called habitable zone of M-dwarf stars via radial velocity measurements, the characterization of exoplanet atmospheres, and the study of magnetic fields in low mass stars and brown dwarfs. CRIRES+ will maintain the high resolving power (R = 100,000) of its predecessor in the Y, J, H, K, L and M bands, but it will include the following improvements: 1) CRIRES+ will be cross-dispersed recording 8-9 diffraction orders at a time, increasing the observing efficiency approximately by an order of magnitude. 2) New detectors with better sensitivity and cosmetics over the old devices. 3) A new gas absorption cell for improved wavelength calibration. This along with the increased wavelength coverage should yield a radial velocity measurement precision to better than 2-5 m/s in K-band. In addition, in Y to K bands, a new Fabry-Perot etalon device will ensure a precision of 100 m/s. 4) A polarimetric unit which will measure both circular and linear polarization. We present the current status and schedule of the project. The instrument is currently scheduled to be installed at the telescope beginning 2018.

  3. Machine Learning based photometric redshifts for the KiDS ESO DR2 galaxies

    CERN Document Server

    Cavuoti, Stefano; Tortora, Crescenzo; Longo, Giuseppe; Napolitano, Nicola R; Radovich, Mario; La Barbera, Francesco; Capaccioli, Massimo; de Jong, Jelte T A; Getman, Fedor; Grado, Aniello; Paolillo, Maurizio

    2015-01-01

    We estimated photometric redshifts (zphot) for more than 1.1 million galaxies of the ESO Public Kilo-Degree Survey (KiDS) Data Release 2. KiDS is an optical wide-field imaging survey carried out with the VLT Survey Telescope (VST) and the OmegaCAM camera, which aims at tackling open questions in cosmology and galaxy evolution, such as the origin of dark energy and the channel of galaxy mass growth. We present a catalogue of photometric redshifts obtained using the Multi Layer Perceptron with Quasi Newton Algorithm (MLPQNA) model, provided within the framework of the DAta Mining and Exploration Web Application REsource (DAMEWARE). These photometric redshifts are based on a spectroscopic knowledge base which was obtained by merging spectroscopic datasets from GAMA (Galaxy And Mass Assembly) data release 2 and SDSS-III data release 9. The overall 1 sigma uncertainty on Delta z = (zspec - zphot) / (1+ zspec) is ~ 0.03, with a very small average bias of ~ 0.001, a NMAD of ~ 0.02 and a fraction of catastrophic outl...

  4. Statistical methods of automatic spectral classification and their application to the Hamburg/ESO Survey

    CERN Document Server

    Christlieb, N; Grasshoff, G; Christlieb, Norbert; Wisotzki, Lutz; Grasshoff, Gerd

    2002-01-01

    We employ classical statistical methods of multivariate classification for the exploitation of the stellar content of the Hamburg/ESO objective prism survey (HES). In a simulation study we investigate the precision of a three-dimensional classification (Teff, log g, [Fe/H]) achievable in the HES for stars in the effective temperature range 520010 (typically corresponding to B_J<16.5). The accuracies in log g and [Fe/H] are better than 0.68dex in the same S/N range. These precisions allow for a very efficient selection of metal-poor stars in the HES. We present a minimum cost rule for compilation of complete samples of objects of a given class, and a rejection rule for identification of corrupted or peculiar spectra. The algorithms we present are being used for the identification of other interesting objects in the HES data base as well, and they are applicable to other existing and future large data sets, such as those to be compiled by the DIVA and GAIA missions.

  5. X-shooter, the new wide band intermediate resolution spectrograph at the ESO Very Large Telescope

    CERN Document Server

    Vernet, Joel; D'Odorico, S; Kaper, L; Kjaergaard, P; Hammer, F; Randich, S; Zerbi, F; Groot, P M; Hjorth, J; Guinouard, I; Navarro, R; Adolfse, T; Albers, P W; Amans, J -P; Andersen, J J; Andersen, M I; Binetruy, P; Bristow, P; Castillo, R; Chemla, F; Christensen, L; Conconi, P; Conzelmann, R; Dam, J; De Caprio, V; Postigo, A De Ugarte; Delabre, B; Di Marcantonio, P; Downing, M; Elswijk, E; Finger, G; Fischer, G; Flores, H; Francois, P; Goldoni, P; Guglielmi, L; Haigron, R; Hanenburg, H; Hendriks, I; Horrobin, M; Horville, D; Jessen, N C; Kerber, F; Kern, L; Kiekebusch, M; Kleszcz, P; Klougart, J; Kragt, J; Larsen, H H; Lizon, J -L; Lucuix, C; Mainieri, V; Manuputy, R; Martayan, C; Mason, E; Mazzoleni, R; Michaelsen, N; Modigliani, A; Moehler, S; Møller, P; Sørensen, A Norup; Nørregaard, P; Peroux, C; Patat, F; Pena, E; Pragt, J; Reinero, C; Riga, F; Riva, M; Roelfsema, R; Royer, F; Sacco, G; Santin, P; Schoenmaker, T; Spano, P; Sweers, E; Ter Horst, R; Tintori, M; Tromp, N; van Dael, P; van der Vliet, H; Venema, L; Vidali, M; Vinther, J; Vola, P; Winters, R; Wistisen, D; Wulterkens, G; Zacchei, A

    2011-01-01

    X-shooter is the first 2nd generation instrument of the ESO Very Large Telescope(VLT). It is a very efficient, single-target, intermediate-resolution spectrograph that was installed at the Cassegrain focus of UT2 in 2009. The instrument covers, in a single exposure, the spectral range from 300 to 2500 nm. It is designed to maximize the sensitivity in this spectral range through dichroic splitting in three arms with optimized optics, coatings, dispersive elements and detectors. It operates at intermediate spectral resolution (R~4,000 - 17,000, depending on wavelength and slit width) with fixed echelle spectral format (prism cross-dispersers) in the three arms. It includes a 1.8"x4" Integral Field Unit as an alternative to the 11" long slits. A dedicated data reduction package delivers fully calibrated two-dimensional and extracted spectra over the full wavelength range. We describe the main characteristics of the instrument and present its performance as measured during commissioning, science verification and ...

  6. HST/ACS Lyman alpha imaging of the nearby starburst ESO338-IG04

    CERN Document Server

    Hayes, M; Mas-Hesse, J M; Kunth, D; Leitherer, C; Petrosian, A

    2005-01-01

    ESO338-IG04 is a well known, local, luminous Blue Compact Galaxy. It has a complex morphology and contains a central young starburst with compact young star clusters. The galaxy was imaged using HST/ACS in the Lyman alpha line and continuum. Using the Starburst99 synthetic spectra and other imaging data from HST/WFPC2 we developed a technique that allows us to make the first photometrically valid continuum subtraction for the LYa line. Our results are in qualitative agreement with the models of LYa escape being regulated by kinematical properties of the interstellar medium. The line-only image shows LYa in both emission and absorption. Notably, emission is seen from central bright young clusters and is in spatial agreement with the features present in a longslit spectrum taken with HST/STIS. Diffuse LYa emission regions are seen surrounding the central starburst where photons escape after one or more resonant scatterings in HI. These regions dominate the total LYa output. Photometry reveals a total LYa flux o...

  7. Bright Metal-Poor Stars from the Hamburg/ESO Survey. II. A Chemodynamical Analysis

    CERN Document Server

    Beers, Timothy C; Carollo, Daniela; Rossi, Silvia; Frebel, Anna; Norris, John E; Dietz, Sarah; Masseron, Thomas

    2016-01-01

    We obtain estimates of stellar atmospheric parameters for a previously published sample of 1777 relatively bright (9 < B < 14) metal-poor candidates from the Hamburg/ESO Survey. The original Frebel et al. analysis of these stars was only able to derive estimates of [Fe/H] and [C/Fe] for a subset of the sample, due to limitations in the methodology then available. A new spectroscopic analysis pipeline has been used to obtain estimates of Teff, log g, [Fe/H], and [C/Fe] for almost the entire dataset. This sample is very local - about 90% of the stars are located within 0.5 kpc of the Sun. We consider the chemodynamical properties of these stars in concert with a similarly local sample of stars from a recent analysis of the Bidelman & MacConnell 'weak-metal' candidates by Beers et al. We use this combined sample to identify possible members of the suggested halo stream of stars by Helmi et al. and Chiba & Beers, as well as stars that may be associated with stripped debris from the putative parent d...

  8. The Gaia-ESO Survey: Catalogue of H$\\alpha$ emission stars

    CERN Document Server

    Traven, Gregor; Van Eck, Sophie; Klutsch, Alexis; Bonito, Rosaria; Lanzafame, Alessandro C; Alfaro, Emilio J; Bayo, Amelia; Bragaglia, Angela; Costado, María Teresa; Damiani, Francesco; Flaccomio, Ettore; Frasca, Antonio; Hourihane, Anna; Jimenez-Esteban, Fran; Lardo, Carmela; Morbidelli, Lorenzo; Pancino, Elena; Prisinzano, Loredana; Sacco, Germano G; Worley, Clare C

    2015-01-01

    We discuss the properties of H$\\alpha$ emission stars across the sample of 22035 spectra from the Gaia-ESO Survey internal data release, observed with the GIRAFFE instrument and largely belonging to stars in young open clusters. Automated fits using two independent Gaussian profiles and a third component that accounts for the nebular emission allow us to discern distinct morphological types of H$\\alpha$ line profiles with the introduction of a simplified classification scheme. All in all we find 3765 stars with intrinsic emission and sort their spectra into eight distinct morphological categories: single--component emission, emission blend, sharp emission peaks, double emission, P-Cygni, inverted P-Cygni, self--absorption, and emission in absorption. We have more than one observation for 1430 stars in our sample, thus allowing a quantitative discussion of the degree of variability of H$\\alpha$ emission profiles, which is expected for young, active objects. We present a catalogue of stars with properties of th...

  9. La modelización matemática en cuarto de la ESO

    Directory of Open Access Journals (Sweden)

    L. Sierra

    2011-06-01

    Full Text Available En este trabajo se presenta un ejemplo de cómo enseñar las matemáticas desde una perspectiva diferente y motivadora para los estudiantes de Educación Secundaria Obligatoria (ESO. La realización de modelos matemáticos es una actividad creativa que, dirigida de forma adecuada, se puede introducir de forma sencilla. Esto implica una renovación tanto de las metodologías en el aula como del tipo de habilidades evaluadas en los estudiantes, especialmente dentro de unos objetivos genéricos que van desde la formación de ciudadanos competentes matemáticamente, hasta los primeros pasos en la formación de los futuros científicos, técnicos y matemáticos. La modelización matemática es una forma diferente de presentar y trabajar las matemáticas en el aula, que permite, además, acercarlos al universo de sus intereses, influyendo en los resultados conseguidos. En este trabajo se presenta la experiencia que ha empezado a llevarse a término en el IES Moixent y el trabajo ya desarrollado hasta ahora.

  10. Deep Impact High Resolution Optical Spectroscopy with the ESO VLT and the Keck 1 telescope

    CERN Document Server

    Jehin, E; Cochran, A L; Hutsemékers, D; Jackson, W M; Manfroid, J; Rauer, H; Schulz, R; Zucconi, J M

    2006-01-01

    We report on observations of comet 9P/Tempel 1 carried out before, during, and after the NASA DEEP IMPACT event (UT July 4), with the optical spectrometers UVES and HIRES mounted on the telescopes Kueyen of the ESO VLT (Chile) and Keck 1 on Mauna Kea (Hawaii), respectively. A total observing time of about 60 hours, distributed over 15 nights around the impact date, allowed us (i) to find a periodic variation of 1.709 +/- 0.009 day in the CN and NH flux, explained by the presence of two major active regions; (ii) to derive a lifetime > ~ 5 x 10^4 s for the parent of the CN radical from a simple modeling of the CN light curve after the impact; (iii) to follow the gas and dust spatial profiles evolution during the 4 hours following the impact and derive the projected velocities (400 m/s and 150 m/s respectively); (iv) to show that the material released by the impact has the same carbon and nitrogen isotopic composition as the surface material (12C/13C = 95 +/- 15 and 14N/15N = 145 +/- 20).

  11. Gaia-ESO Survey: Gas dynamics in the Carina Nebula through optical emission lines

    CERN Document Server

    Damiani, F; Magrini, L; Prisinzano, L; Mapelli, M; Micela, G; Kalari, V; Apellaniz, J Maiz; Gilmore, G; Randich, S; Alfaro, E; Flaccomio, E; Koposov, S; Klutsch, A; Lanzafame, A C; Pancino, E; Sacco, G G; Bayo, A; Carraro, G; Casey, A R; Costado, M T; Franciosini, E; Hourihane, A; Lardo, C; Lewis, J; Monaco, L; Morbidelli, L; Worley, C; Zaggia, S; Zwitter, T; Dorda, R

    2016-01-01

    We present observations from the Gaia-ESO Survey in the lines of H$\\alpha$, [N II], [S II] and He I of nebular emission in the central part of the Carina Nebula. We investigate the properties of the two already known kinematic components (approaching and receding, respectively), which account for the bulk of emission. Moreover, we investigate the features of the much less known low-intensity high-velocity (absolute RV $>$50 km/s) gas emission. We show that gas giving rise to H$\\alpha$ and He I emission is dynamically well correlated, but not identical, to gas seen through forbidden-line emission. Gas temperatures are derived from line-width ratios, and densities from [S II] doublet ratios. The spatial variation of N ionization is also studied, and found to differ between the approaching and receding components. The main result is that the bulk of the emission lines in the central part of Carina arises from several distinct shell-like expanding regions, the most evident found around $\\eta$ Car, the Trumpler 14...

  12. The Gaia-ESO Survey: N-body modelling of the Gamma Velorum cluster

    CERN Document Server

    Mapelli, M; Jeffries, R D; Gavagnin, E; Gaudin, T Cantat; Sacco, G G; Meyer, M R; Alfaro, E J; Costado, M; Damiani, F; Frasca, A; Lanzafame, A C; Randich, S; Sordo, R; Zaggia, S; Micela, G; Flaccomio, E; Pancino, E; Bergemann, M; Hourihane, A; Lardo, C; Magrini, L; Morbidelli, L; Prisinzano, L; Worley, C C

    2015-01-01

    The Gaia-ESO Survey has recently unveiled the complex kinematic signature of the Gamma Velorum cluster: this cluster is composed of two kinematically distinct populations (hereafter, population A and B), showing two different velocity dispersions and a relative ~2 km s^-1 radial velocity (RV) shift. In this paper, we propose that the two populations of the Gamma Velorum cluster originate from two different sub-clusters, born from the same parent molecular cloud. We investigate this possibility by means of direct-summation N-body simulations. Our scenario is able to reproduce not only the RV shift and the different velocity dispersions, but also the different centroid (~0.5 pc), the different spatial concentration and the different line-of-sight distance (~5 pc) of the two populations. The observed 1-2 Myr age difference between the two populations is also naturally explained by our scenario, in which the two sub-clusters formed in two slightly different star formation episodes. Our simulations suggest that po...

  13. The Gaia-ESO Survey: Probes of the inner disk abundance gradient

    CERN Document Server

    Jacobson, H R; Jilkova, L; Magrini, L; Bragaglia, A; Vallenari, A; Tosi, M; Randich, S; Donati, P; Cantat-Gaudin, T; Sordo, R; Smiljanic, R; Overbeek, J C; Carraro, G; Tautvaisiene, G; Roman, I San; Villanova, S; Geisler, D; Munoz, C; Jimenez-Esteban, F; Tang, B; Gilmore, G; Alfaro, E J; Bensby, T; Flaccomio, E; Koposov, S E; Korn, A J; Pancino, E; Recio-Blanco, A; Casey, A R; Costado, M T; Franciosini, E; Heiter, U; Hill, V; Hourihane, A; Lardo, C; de Laverny, P; Lewis, J; Monaco, L; Morbidelli, L; Sacco, G G; Sousa, S G; Worley, C C; Zaggia, S

    2016-01-01

    The nature of the metallicity gradient inside the solar circle (R_GC < 8 kpc) is poorly understood, but studies of Cepheids and a small sample of open clusters suggest that it steepens in the inner disk. We investigate the metallicity gradient of the inner disk using a sample of inner disk open clusters that is three times larger than has previously been studied in the literature to better characterize the gradient in this part of the disk. We used the Gaia-ESO Survey (GES) [Fe/H] values and stellar parameters for stars in 12 open clusters in the inner disk from GES-UVES data. Cluster mean [Fe/H] values were determined based on a membership analysis for each cluster. Where necessary, distances and ages to clusters were determined via comparison to theoretical isochrones. The GES open clusters exhibit a radial metallicity gradient of -0.10+-0.02 dex/kpc, consistent with the gradient measured by other literature studies of field red giant stars and open clusters in the range R_GC ~ 6-12 kpc. We also measure ...

  14. The Gaia-ESO Survey: Stellar content and elemental abundances in the massive cluster NGC\\,6705

    CERN Document Server

    Cantat-Gaudin, T; Zaggia, S; Bragaglia, A; Sordo, R; Drew, J E; Eisloeffel, J; Farnhill, H J; Gonzalez-Solares, E; Greimel, R; Irwin, M J; Kupcu-Yoldas, A; Jordi, C; Blomme, R; Sampedro, L; Costado, M T; Alfaro, E; Smiljanic, R; Magrini, L; Donati, P; Friel, E D; Jacobson, H; Abbas, U; Hatzidimitriou, D; Spagna, A; Vecchiato, A; Balaguer-Nunez, L; Lardo, C; Tosi, M; Pancino, E; Klutsch, A; Tautvaisiene, G; Drazdauskas, A; Puzeras, E; Jimenez-Esteban, F; Maiorca, E; Geisler, D; San, I; Villanova, S; Gilmore, G; Randich, S; Bensby, T; Flaccomio, E; Lanzafame, A; Recio-Blanco, A; Damiani, F; Hourihane, A; Jofre, P; deLaverny, P; Masseron, T; Morbidelli, L; Prisinzano, L; Sacco, G G; Sbordone, L; Worley, C C

    2014-01-01

    Chemically inhomogeneous populations are observed in most globular clusters, but not in open clusters. Cluster mass seems to play a key role in the existence of multiple populations. Studying the chemical homogeneity of the most massive open clusters is necessary to better understand the mechanism of their formation and determine the mass limit under which clusters cannot host multiple populations. Here we studied NGC6705, that is a young and massive open cluster located towards the inner region of the Milky Way. This cluster is located inside the solar circle. This makes it an important tracer of the inner disk abundance gradient. This study makes use of BVI and ri photometry and comparisons with theoretical isochrones to derive the age of NGC6705. We study the density profile of the cluster and the mass function to infer the cluster mass. Based on abundances of the chemical elements distributed in the first internal data release of the Gaia-ESO Survey, we study elemental ratios and the chemical homogeneity ...

  15. The Gaia-ESO Survey: Insights on the inner-disc evolution from open clusters

    CERN Document Server

    Magrini, L; Donati, P; Bragaglia, A; Adibekyan, V; Romano, D; Smiljanic, R; Blanco-Cuaresma, S; Tautvaisiene, G; Friel, E; Overbeek, J; Jacobson, H; Cantat-Gaudin, T; Vallenari, A; Sordo, R; Pancino, E; Geisler, D; Roman, I San; Villanova, S; Casey, A; Hourihane, A; Worley, C C; Francois, P; Gilmore, G; Bensby, T; Flaccomio, E; Korn, A J; Recio-Blanco, A; Carraro, G; Costado, M T; Franciosini, E; Heiter, U; Jofree, P; Lardo, C; de Laverny, P; Monaco, L; Morbidelli, L; Sacco, G; Sousa, S G; Zaggia, S

    2015-01-01

    Context. The inner disc, linking the thin disc with the bulge, has been somehow neglected in the past because of intrinsic difficulties in its study, due, e.g., to crowding and high extinction. Open clusters located in the inner disc are among the best tracers of its chemistry at different ages and distances. Aims. We analyse the chemical patterns of four open clusters located within 7 kpc of the Galactic Centre and of field stars to infer the properties of the inner disc with the Gaia-ESO survey idr2/3 data release. Methods. We derive the parameters of the newly observed cluster, Berkeley 81, finding an age of about 1 Gyr and a Galactocentric distance of 5.4 kpc. We construct the chemical patterns of clusters and we compare them with those of field stars in the Solar neighbourhood and in the inner-disc samples. Results. Comparing the three populations we observe that inner-disc clusters and field stars are both, on average, enhanced in [O/Fe], [Mg/Fe] and [Si/Fe]. Using the idr2/3 results of M67, we estimate...

  16. Ghosts of Milky Way's past: the globular cluster ESO 37-1 (E 3)

    CERN Document Server

    Marcos, R de la Fuente; Bidin, C Moni; Ortolani, S; Carraro, G

    2015-01-01

    Context. In the Milky Way, most globular clusters are highly conspicuous objects that were found centuries ago. However, a few dozen of them are faint, sparsely populated systems identified largely during the second half of the past century. One of the faintest is ESO 37-1 (E 3) and as such it remains poorly studied, with no spectroscopic observations published so far, although it was discovered in 1976. Aims. We investigate the globular cluster E 3 in an attempt to better constrain its fundamental parameters. Spectroscopy of stars in the field of E 3 is shown here for the first time. Methods. Deep, precise VI CCD photometry of E 3 down to V=26 mag is presented and analyzed. Low resolution, medium signal-to-noise ratio spectra of 9 candidate members are studied to derive radial velocity and metallicity. Proper motions from the UCAC4 catalogue are used to explore the kinematics of the bright members of E 3. Results. Isochrone fitting indicates that E 3 is probably very old, with an age of about 13 Gyr; its dis...

  17. Photometric redshifts and cluster tomography in the ESO Distant Cluster Survey

    CERN Document Server

    Pellò, R; De Lucia, G; Simard, L; Clowe, D I; Jablonka, P; Milvang-Jensen, B; Saglia, R P; White, S D M; Aragón-Salamanca, A; Halliday, C; Poggianti, B; Best, P; Dalcanton, J; Dantel-Fort, M; Fort, B; Von der Linden, A; Mellier, Y; Rottgering, H; Zaritsky, D

    2009-01-01

    This paper reports the results obtained on the photometric redshifts measurement and accuracy, and cluster tomography in the ESO Distant Cluster Survey (EDisCS) fields. Photometric redshifts were computed using two independent codes (Hyperz and G. Rudnick's code). The accuracy of photometric redshifts was assessed by comparing our estimates with the spectroscopic redshifts of ~1400 galaxies in the 0.3

  18. Spectroscopy of clusters in the ESO Distant Cluster Survey (EDisCS)

    CERN Document Server

    Halliday, C; Poirier, S; Poggianti, B M; Jablonka, P; Aragón-Salamanca, A; Saglia, R P; De Lucia, G; Pellò, R; Simard, L; Clowe, D I; Rudnick, G; Dalcanton, J J; White, S D M; Zaritsky, D

    2004-01-01

    We present spectroscopic observations of galaxies in 4 clusters at z = 0.7-0.8 and in one cluster at z~0.5 obtained with the FORS2 spectrograph on the VLT as part of the ESO Distant Cluster Survey (EDisCS), a photometric and spectroscopic survey of 20 intermediate to high redshift clusters. We describe our target selection, mask design, observation and data reduction procedures, using these first 5 clusters to demonstrate how our strategies maximise the number of cluster members for which we obtain spectroscopy. We present catalogues containing positions, I-band magnitudes and spectroscopic redshifts for galaxies in the fields of our 5 clusters. These contain 236 cluster members, with the number of members per cluster ranging from 30 to 67. Our spectroscopic success rate, i.e. the fraction of spectroscopic targets which are cluster members, averages 50% and ranges from 30% to 75%. We use a robust biweight estimator to measure cluster velocity dispersions from our spectroscopic redshift samples. We also make a...

  19. Hábitos lectores y competencia literaria al final de la E.S.O.

    Directory of Open Access Journals (Sweden)

    Víctor Latorre Zacarés

    2007-01-01

    Full Text Available Este artículo describe los resultados y las conclusiones de un trabajo de investigación sobre hábitos de lectura y competencia literaria en alumnos de 4º de la E.S.O. El proyecto surgió de la necesidad de obtener datos concretos sobre la competencia literaria de los alumnos. Los profesores hablan muchísimo sobre lo que saben o no saben los alumnos, lo que deben o no hacer, lo que tienen o no que hacer ellos y, también, los responsables de la política educativa. Es decir, los profesores verbalizan sus reflexiones, pero, sólo en contadas ocasiones, lo hacen de manera sistemática. El trabajo aporta datos concretos sobre gustos literarios, hábitos lectores, consumo de ficción, conocimientos literarios, etc.; datos cuya finalidad es la de convertir conceptos espontáneos en conceptos más científicos, que son los que permitirán modificar aquellos aspectos en los que el alumnado presenta deficiencias.

  20. Pathogenesis of PR3-ANCA associated vasculitis

    NARCIS (Netherlands)

    Kallenberg, C. G. M.

    2008-01-01

    Wegener's Granulomatosis (WG) is closely associated with antineutrophil cytoplasmic autoantibodies (ANCA), particularly those directed to proteinase 3 (PR3). ANCA directed to myeloperoxidase (MPO) are associated with microscopic polyangiitis (MPA) and the Churg Strauss syndrome. PR3-ANCA associated