WorldWideScience

Sample records for human exploration activities

  1. Supporting Human Activities - Exploring Activity-Centered Computing

    DEFF Research Database (Denmark)

    Christensen, Henrik Bærbak; Bardram, Jakob

    2002-01-01

    In this paper we explore an activity-centered computing paradigm that is aimed at supporting work processes that are radically different from the ones known from office work. Our main inspiration is healthcare work that is characterized by an extreme degree of mobility, many interruptions, ad-hoc...

  2. Exploring Human Activity Patterns Using Taxicab Static Points

    Directory of Open Access Journals (Sweden)

    Bin Jiang

    2012-06-01

    Full Text Available This paper explores the patterns of human activities within a geographical space by adopting the taxicab static points which refer to the locations with zero speed along the tracking trajectory. We report the findings from both aggregated and individual aspects. Results from the aggregated level indicate the following: (1 Human activities exhibit an obvious regularity in time, for example, there is a burst of activity during weekend nights and a lull during the week. (2 They show a remarkable spatial drifting pattern, which strengthens our understanding of the activities in any given place. (3 Activities are heterogeneous in space irrespective of their drifting with time. These aggregated results not only help in city planning, but also facilitate traffic control and management. On the other hand, investigations on an individual level suggest that (4 activities witnessed by one taxicab will have different temporal regularity to another, and (5 each regularity implies a high level of prediction with low entropy by applying the Lempel-Ziv algorithm.

  3. Collaborative Human Engineering Work in Space Exploration Extravehicular Activities (EVA)

    Science.gov (United States)

    DeSantis, Lena; Whitmore, Mihriban

    2007-01-01

    A viewgraph presentation on extravehicular activities in space exploration in collaboration with other NASA centers, industries, and universities is shown. The topics include: 1) Concept of Operations for Future EVA activities; 2) Desert Research and Technology Studies (RATS); 3) Advanced EVA Walkback Test; 4) Walkback Subjective Results; 5) Integrated Suit Test 1; 6) Portable Life Support Subsystem (PLSS); 7) Flex PLSS Design Process; and 8) EVA Information System; 9)

  4. Exploring Techniques for Vision Based Human Activity Recognition: Methods, Systems, and Evaluation

    Directory of Open Access Journals (Sweden)

    Hong Zhang

    2013-01-01

    Full Text Available With the wide applications of vision based intelligent systems, image and video analysis technologies have attracted the attention of researchers in the computer vision field. In image and video analysis, human activity recognition is an important research direction. By interpreting and understanding human activity, we can recognize and predict the occurrence of crimes and help the police or other agencies react immediately. In the past, a large number of papers have been published on human activity recognition in video and image sequences. In this paper, we provide a comprehensive survey of the recent development of the techniques, including methods, systems, and quantitative evaluation towards the performance of human activity recognition.

  5. Human exploration mission studies

    Science.gov (United States)

    Cataldo, Robert L.

    1989-01-01

    The Office of Exploration has established a process whereby all NASA field centers and other NASA Headquarters offices participate in the formulation and analysis of a wide range of mission strategies. These strategies were manifested into specific scenarios or candidate case studies. The case studies provided a systematic approach into analyzing each mission element. First, each case study must address several major themes and rationale including: national pride and international prestige, advancement of scientific knowledge, a catalyst for technology, economic benefits, space enterprise, international cooperation, and education and excellence. Second, the set of candidate case studies are formulated to encompass the technology requirement limits in the life sciences, launch capabilities, space transfer, automation, and robotics in space operations, power, and propulsion. The first set of reference case studies identify three major strategies: human expeditions, science outposts, and evolutionary expansion. During the past year, four case studies were examined to explore these strategies. The expeditionary missions include the Human Expedition to Phobos and Human Expedition to Mars case studies. The Lunar Observatory and Lunar Outpost to Early Mars Evolution case studies examined the later two strategies. This set of case studies established the framework to perform detailed mission analysis and system engineering to define a host of concepts and requirements for various space systems and advanced technologies. The details of each mission are described and, specifically, the results affecting the advanced technologies required to accomplish each mission scenario are presented.

  6. Cosmochemistry and Human Exploration

    Science.gov (United States)

    Taylor, G. J.

    2004-12-01

    About 125 scientists, engineers, business men and women, and other specialists attended the sixth meeting of the Space Resources Roundtable, held at the Colorado School of Mines in Golden, Colorado. The meeting was co-sponsored by the Space Resources Roundtable, Inc. (a nonprofit organization dedicated to the use of space resources for the benefit of humankind), the Lunar and Planetary Institute, and the Colorado School of Mines. Presentations and discussions during the meeting made it clear that the knowledge gained from cosmochemical studies of the Moon and Mars is central to devising ways to use in situ resources. This makes cosmochemistry central to the human exploration and development of space, which cannot happen without extensive in situ resource utilization (ISRU). Cosmochemists at the meeting reported on an array of topics: the nature of lunar surface materials and our lack of knowledge about surface materials in permanently shadowed regions at the lunar poles; how to make reasonable simulated lunar materials for resource extraction testbeds, vehicle design tests, and construction experiments on Earth; and how to explore for resources on the Moon and Mars.

  7. Exploring associations between gaze patterns and putative human mirror neuron system activity.

    Science.gov (United States)

    Donaldson, Peter H; Gurvich, Caroline; Fielding, Joanne; Enticott, Peter G

    2015-01-01

    The human mirror neuron system (MNS) is hypothesized to be crucial to social cognition. Given that key MNS-input regions such as the superior temporal sulcus are involved in biological motion processing, and mirror neuron activity in monkeys has been shown to vary with visual attention, aberrant MNS function may be partly attributable to atypical visual input. To examine the relationship between gaze pattern and interpersonal motor resonance (IMR; an index of putative MNS activity), healthy right-handed participants aged 18-40 (n = 26) viewed videos of transitive grasping actions or static hands, whilst the left primary motor cortex received transcranial magnetic stimulation. Motor-evoked potentials recorded in contralateral hand muscles were used to determine IMR. Participants also underwent eyetracking analysis to assess gaze patterns whilst viewing the same videos. No relationship was observed between predictive gaze and IMR. However, IMR was positively associated with fixation counts in areas of biological motion in the videos, and negatively associated with object areas. These findings are discussed with reference to visual influences on the MNS, and the possibility that MNS atypicalities might be influenced by visual processes such as aberrant gaze pattern.

  8. Exploring associations between gaze patterns and putative human mirror neuron system activity

    Directory of Open Access Journals (Sweden)

    Peter Hugh Donaldson

    2015-07-01

    Full Text Available The human mirror neuron system (MNS is hypothesised to be crucial to social cognition. Given that key MNS-input regions such as the superior temporal sulcus are involved in biological motion processing, and mirror neuron activity in monkeys has been shown to vary with visual attention, aberrant MNS function may be partly attributable to atypical visual input. To examine the relationship between gaze pattern and interpersonal motor resonance (IMR; an index of putative MNS activity, healthy right-handed participants aged 18-40 (n = 26 viewed videos of transitive grasping actions or static hands, whilst the left primary motor cortex received transcranial magnetic stimulation (TMS. Motor-evoked potentials (MEPs recorded in contralateral hand muscles were used to determine IMR. Participants also underwent eyetracking analysis to assess gaze patterns whilst viewing the same videos. No relationship was observed between predictive gaze (PG and IMR. However, IMR was positively associated with fixation counts in areas of biological motion in the videos, and negatively associated with object areas. These findings are discussed with reference to visual influences on the MNS, and the possibility that MNS atypicalities might be influenced by visual processes such as aberrant gaze pattern.

  9. Human Power Empirically Explored

    Energy Technology Data Exchange (ETDEWEB)

    Jansen, A.J.

    2011-01-18

    Harvesting energy from the users' muscular power to convert this into electricity is a relatively unknown way to power consumer products. It nevertheless offers surprising opportunities for product designers; human-powered products function independently from regular power infrastructure, are convenient and can be environmentally and economically beneficial. This work provides insight into the knowledge required to design human-powered energy systems in consumer products from a scientific perspective. It shows the developments of human-powered products from the first introduction of the BayGen Freeplay radio in 1995 till current products and provides an overview and analysis of 211 human-powered products currently on the market. Although human power is generally perceived as beneficial for the environment, this thesis shows that achieving environmental benefit is only feasible when the environmental impact of additional materials in the energy conversion system is well balanced with the energy demands of the products functionality. User testing with existing products showed a preference for speeds in the range of 70 to 190 rpm for crank lengths from 32 to 95 mm. The muscular input power varied from 5 to 21 W. The analysis of twenty graduation projects from the Faculty of Industrial Design Engineering in the field of human-powered products, offers an interesting set of additional practice based design recommendations. The knowledge based approach of human power is very powerful to support the design of human-powered products. There is substantial potential for improvements in the domains energy conversion, ergonomics and environment. This makes that human power, when applied properly, is environmentally and economically competitive over a wider range of applications than thought previously.

  10. Human Expeditions to Near-Earth Asteroids: An Update on NASA's Status and Proposed Activities for Small Body Exploration

    Science.gov (United States)

    Abell, Paul; Mazanek, Dan; Barbee, Brent; Landis, Rob; Johnson, Lindley; Yeomans, Don; Reeves, David; Drake, Bret; Friedensen, Victoria

    2013-01-01

    Over the past several years, much attention has been focused on the human exploration of near-Earth asteroids (NEAs). Two independent NASA studies examined the feasibility of sending piloted missions to NEAs, and in 2009, the Augustine Commission identified NEAs as high profile destinations for human exploration missions beyond the Earth- Moon system as part of the Flexible Path. More recently the current U.S. presidential administration directed NASA to include NEAs as destinations for future human exploration with the goal of sending astronauts to a NEA in the mid to late 2020s. This directive became part of the official National Space Policy of the United States of America as of June 28, 2010. The scientific and hazard mitigation benefits, along with the programmatic and operational benefits of a human venture beyond the Earth-Moon system, make a mission to a NEA using NASA s proposed exploration systems a compelling endeavor.

  11. Applied Nanotechnology for Human Space Exploration

    Science.gov (United States)

    Yowell, Leonard L.

    2007-01-01

    A viewgraph presentation describing nanotechnology for human space exploration is shown. The topics include: 1) NASA's Strategic Vision; 2) Exploration Architecture; 3) Future Exploration Mission Requirements Cannot be met with Conventional Materials; 4) Nanomaterials: Single Wall Carbon Nanotubes; 5) Applied Nanotechnology at JSC: Fundamentals to Applications; 6) Technology Readiness Levels (TRL); 7) Growth, Modeling, Diagnostics and Production; 8) Characterization: Purity, Dispersion and Consistency; 9) Processing; 10) Nanoelectronics: Enabling Technologies; 11) Applications for Human Space Exploration; 12) Exploration Life Support: Atmosphere Revitalization System; 13) Advanced and Exploration Life Support: Regenerable CO2 Removal; 14) Exploration Life Support: Water Recovery; 15) Advanced Life Support: Water Disinfection/Recovery; 16) Power and Energy: Supercapacitors and Fuel Cells; 17) Nanomaterials for EMI Shielding; 18) Active Radiation Dosimeter; 19) Advanced Thermal Protection System (TPS) Repair; 20) Thermal Radiation and Impact Protection (TRIPS); 21) Nanotechnology: Astronaut Health Management; 22) JSC Nanomaterials Group Collaborations.

  12. Human Missions to Near-Earth Asteroids: An Update on NASA's Current Status and Proposed Activities for Small Body Exploration

    Science.gov (United States)

    Abell, P. A.; Mazanek, D. D.; Barbee, B. W.; Mink, R. G.; Landis, R. R.; Adamo, D. R.; Johnson, L. N.; Yeomans, D. K.; Reeves, D. M.; Larman, K. T.; hide

    2012-01-01

    Over the past several years, much attention has been focused on the human exploration of near-Earth asteroids (NEAs). Two independent NASA studies examined the feasibility of sending piloted missions to NEAs, and in 2009, the Augustine Commission identified NEAs as high profile destinations for human exploration missions beyond the Earth-Moon system as part of the Flexible Path. More recently the current U.S. presidential administration directed NASA to include NEAs as destinations for future human exploration with the goal of sending astronauts to a NEA in the mid to late 2020s. This directive became part of the official National Space Policy of the United States of America as of June 28, 2010.

  13. Robots and humans: synergy in planetary exploration

    Science.gov (United States)

    Landis, Geoffrey A.

    2004-01-01

    How will humans and robots cooperate in future planetary exploration? Are humans and robots fundamentally separate modes of exploration, or can humans and robots work together to synergistically explore the solar system? It is proposed that humans and robots can work together in exploring the planets by use of telerobotic operation to expand the function and usefulness of human explorers, and to extend the range of human exploration to hostile environments. Published by Elsevier Ltd.

  14. Uranium reserves and exploration activity

    International Nuclear Information System (INIS)

    Meehan, R.J.

    1975-01-01

    The strategy that ERDA plans to employ regarding resource appraisal is outlined. All types of uranium occurrences will be evaluated as sources of domestic ore reserves. Industry's exploration efforts will be compiled. These data will include information on land acquisition and costs, footage drilled and costs, estimates of exploration activities and expenditures, exploration for non-sandstone deposits, exploration in non-established areas, and foreign exploration plans and costs. Typical data in each of these areas are given

  15. Human Factors in Space Exploration

    Science.gov (United States)

    Jones, Patricia M.; Fiedler, Edna

    2010-01-01

    The exploration of space is one of the most fascinating domains to study from a human factors perspective. Like other complex work domains such as aviation (Pritchett and Kim, 2008), air traffic management (Durso and Manning, 2008), health care (Morrow, North, and Wickens, 2006), homeland security (Cooke and Winner, 2008), and vehicle control (Lee, 2006), space exploration is a large-scale sociotechnical work domain characterized by complexity, dynamism, uncertainty, and risk in real-time operational contexts (Perrow, 1999; Woods et ai, 1994). Nearly the entire gamut of human factors issues - for example, human-automation interaction (Sheridan and Parasuraman, 2006), telerobotics, display and control design (Smith, Bennett, and Stone, 2006), usability, anthropometry (Chaffin, 2008), biomechanics (Marras and Radwin, 2006), safety engineering, emergency operations, maintenance human factors, situation awareness (Tenney and Pew, 2006), crew resource management (Salas et aI., 2006), methods for cognitive work analysis (Bisantz and Roth, 2008) and the like -- are applicable to astronauts, mission control, operational medicine, Space Shuttle manufacturing and assembly operations, and space suit designers as they are in other work domains (e.g., Bloomberg, 2003; Bos et al, 2006; Brooks and Ince, 1992; Casler and Cook, 1999; Jones, 1994; McCurdy et ai, 2006; Neerincx et aI., 2006; Olofinboba and Dorneich, 2005; Patterson, Watts-Perotti and Woods, 1999; Patterson and Woods, 2001; Seagull et ai, 2007; Sierhuis, Clancey and Sims, 2002). The human exploration of space also has unique challenges of particular interest to human factors research and practice. This chapter provides an overview of those issues and reports on sorne of the latest research results as well as the latest challenges still facing the field.

  16. Domestic uranium exploration activities

    International Nuclear Information System (INIS)

    Chenoweth, W.L.

    1980-01-01

    Uranium exploration in the United States reached its alltime high in 1978 when the chief exploration indicator, surface drilling, totaled 47 million feet. In 1979, however, total drilling declined to 41 million feet, and during the first 8 months of 1980 the trend continued, as surface drilling was 27% less than for the same period in 1979. The total drilling for 1980 now is expected to be below 30 million feet, far less than the 39.4 million feet planned by industry at the beginning of the year. Falling uranium prices, the uncertainties of future uranium demand, rising costs, and the possibility of stiff foreign competition are the prime causes for the current reduction in domestic uranium exploration. Uranium exploration in the United States continues to be concentrated in the vicinity of major producing areas such as the San Juan Basin, Wyoming Basins, Texas Coastal Plain, Paradox Basin, and northeastern Washington, and in areas of recent discoveries including the Henry Mountains, Utah, the McDermitt caldera in Nevada and Oregon, and central Colorado. The distributions, by location, of total surface drilling for 1979 and the first half of 1980 are presented

  17. Desk study of the possible impact of fisheries and other human activities on the marine environment in Mauritania. An exploration

    NARCIS (Netherlands)

    Wal, van der J.T.; Goudswaard, P.C.

    2008-01-01

    Wageningen IMARES has been contracted by Dutch Ministry of Agriculture, Nature and Food Quality with funding from the “BO PPP”-programme to make an inventory of existing and expected future human activities in that part of the Eastern Atlantic Ocean that forms the Economic Exclusive zone of

  18. Social Foundations of Human Space Exploration

    CERN Document Server

    Dator, James A

    2012-01-01

    Social Foundations of Human Space Exploration presents a uniquely human perspective on the quest to explore space and to understand the universe through the lens of the arts, humanities, and social sciences. It considers early stories about the universe in various cultures; recent space fiction; the origins and cultural rationale for the space age; experiences of humans in space and their emerging interactions with robots and artificial intelligence; how humans should treat environments and alien life; and the alternative futures of space exploration and settlement.

  19. Strategies For Human Exploration Leading To Human Colonization of Space

    Science.gov (United States)

    Smitherman, David; Everett, Harmon

    2009-01-01

    Enabling the commercial development of space is key to the future colonization of space and key to a viable space exploration program. Without commercial development following in the footsteps of exploration it is difficult to justify and maintain public interest in the efforts. NASA's exploration program has suffered from the lack of a good commercial economic strategy for decades. Only small advances in commercial space have moved forward, and only up to Earth orbit with the commercial satellite industry. A way to move beyond this phase is to begin the establishment of human commercial activities in space in partnership with the human exploration program. In 2007 and 2008, the authors researched scenarios to make space exploration and commercial space development more feasible as part of their graduate work in the Space Architecture Program at the Sasakawa International Center for Space Architecture at the University of Houston, Houston, Texas. Through this research it became apparent that the problems facing future colonization are much larger than the technology being developed or the international missions that our space agencies are pursuing. These issues are addressed in this paper with recommendations for space exploration, commercial development, and space policy that are needed to form a strategic plan for human expansion into space. In conclusion, the authors found that the current direction in space as carried out by our space agencies around the world is definitely needed, but is inadequate and incapable of resolving all of the issues that inhibit commercial space development. A bolder vision with strategic planning designed to grow infrastructures and set up a legal framework for commercial markets will go a long way toward enabling the future colonization of space.

  20. High-Rate Laser Communications for Human Exploration and Science

    Science.gov (United States)

    Robinson, B. S.; Shih, T.; Khatri, F. I.; King, T.; Seas, A.

    2018-02-01

    Laser communication links has been successfully demonstrated on recent near-Earth and lunar missions. We present a status of this development work and its relevance to a future Deep Space Gateway supporting human exploration and science activities.

  1. Science Driven Human Exploration of Mars

    Science.gov (United States)

    McKay, Christopher P.

    2004-01-01

    Mars appears to be cold dry and dead world. However there is good evidence that early in its history it had liquid water, more active volcanism, and a thicker atmosphere. Mars had this earth-like environment over three and a half billion years ago, during the same time that life appeared on Earth. The main question in the exploration of Mars then is the search for a independent origin of life on that planet. Ecosystems in cold, dry locations on Earth - such as the Antarctic - provide examples of how life on Mars might have survived and where to look for fossils. Fossils are not enough. We will want to determine if life on Mars was a separate genesis from life on Earth. For this determination we need to access intact martian life; possibly frozen in the deep old permafrost. Human exploration of Mars will probably begin with a small base manned by a temporary crew, a necessary first start. But exploration of the entire planet will require a continued presence on the Martian surface and the development of a self sustaining community in which humans can live and work for very long periods of time. A permanent Mars research base can be compared to the permanent research bases which several nations maintain in Antarctica at the South Pole, the geomagnetic pole, and elsewhere. In the long run, a continued human presence on Mars will be the most economical way to study that planet in detail. It is possible that at some time in the future we might recreate a habitable climate on Mars, returning it to the life-bearing state it may have enjoyed early in its history. Our studies of Mars are still in a preliminary state but everything we have learned suggests that it may be possible to restore Mars to a habitable climate. Additional information is contained in the original extended abstract.

  2. Astrobiology and the Human Exploration of Mars

    Science.gov (United States)

    Levine, Joel S.; Garvin, James B.; Drake, B. G.; Beaty, David

    2010-01-01

    In March 2007, the Mars Exploration Program Analysis Group (MEPAG) chartered the Human Exploration of Mars Science Analysis Group (HEM-SAG), co-chaired by J. B. Garvin and J. S. Levine and consisting of about 30 Mars scientists from the U.S. and Europe. HEM-SAG was one of a half dozen teams charted by NASA to consider the human exploration of Mars. Other teams included: Mars Entry, Descent and Landing, Human Health and Performance, Flight and Surface Systems, and Heliospheric/Astrophysics. The results of these Mars teams and the development of an architecture for the human exploration of Mars were summarized in two recent publications: Human Exploration of Mars Design Reference Architecture 5.0, NASA Special Publication-2009-566 (B. G. Drake, Editor), 100 pages, July 2009 and Human Exploration of Mars Design Reference Architecture 5.0, NASA Special Publication-2009-566 Addendum (B. G. Drake, Editor), 406 pages, July 2009. This presentation summarizes the HEM-SAG conclusions on astrobiology and the search for life on Mars by humans.

  3. Report on geologic exploration activities

    International Nuclear Information System (INIS)

    Breslin, J.; Laughon, R.B.; Hall, R.J.; Voss, J.W.

    1980-01-01

    This report provides an overview of the geological exploration activities being carried out as part of the National Waste Terminal Storage (NWTS) Program, which has been established by the US Department of Energy (DOE) to develop the technology and provide the facilities for the safe, environmentally acceptable isolation of civilian high-level and transuranic nuclear wastes, including spent fuel elements, for which the Federal government is responsible. The principal programmatic emphasis is on disposal in mined geologic repositories. Explorations are being conducted or planned in various parts of the country to identify potential sites for such repositories. The work is being undertaken by three separate but coordinated NWTS project elements. Under the Basalt Waste Isolation Project (BWIP), basalt formations underlying DOE's Hanford Reservation are being investigated. Granite, tuff, and shale formations at the DOE Nevada Test Site (NTS) are being similarly studied in the Nevada Nuclear Waste Storage Investigations (NNWSI). The Office of Nuclear Waste Isolation (ONWI) is investigating domed salt formations in several Gulf Coast states and bedded salt formations in Utah and Texas. The ONWI siting studies are being expanded to include areas overlying crystalline rocks, shales, and other geohydrologic systems. The current status of these NWTS efforts, including the projected budgets for FY 1981, is summarized, and the criteria and methodology being employed in the explorations are described. The consistency of the overall effort with the recommendations presented in the Report to the President by the Interagency Review Group on Nuclear Waste Management (IRG), as well as with documents representing the national technical consensus, is discussed

  4. Report on geologic exploration activities

    International Nuclear Information System (INIS)

    1980-01-01

    This report provides an overview of the geological exploration activities being carried out as part of the National Waste Terminal Storage (NWTS) Program, which has been established by the US Department of Energy (DOE) to develop the technology and provide the facilities for the safe, environmentally acceptable isolation of civilian high-level and transuranic nuclear wastes, including spent fuel elements, for which the Federal government is reponsible. The principal programmatic emphasis is on disposal in mined geologic repositories. Explorations are being conducted or planned in various parts of the country to identify potential sites for such repositories. The work is being undertaken by three separate but coordinated NWTS project elements. Under the Basalt Waste Isolation Project (BWIP), basalt formations underlying DOE's Hanford Reservation are being investigated. Granite, tuff, and shale formations at the DOE Nevada Test Site (NTS) are being similarly studied in the Nevada Nuclear Waste Storage Investigations (NNWSI). The Office of Nuclear Waste Isolation (ONWI) is investigating domed salt formations in several Gulf Coast states and bedded salt formations in Utah and Texas. Th ONWI siting studies are being expanded to include areas overlying crystalline rocks, shales, and other geohydrologic systems. The current status of these NWTS efforts, including the projected budgets for FY 1981, is summarized, and the criteria and methodology being employed in the explorations are described. The consistency of the overall effort with the recommendations presented in the Report to the President by the Interagency Review Group on Nuclear Waste Management (IRG), as well as with documents representing the national technical consensus, is discussed

  5. Humanity in God's Image: An Interdisciplinary Exploration

    DEFF Research Database (Denmark)

    Welz, Claudia

    . Claudia Welz offers an interdisciplinary exploration of theological and ethical 'visions' of the invisible. By analysing poetry and art, Welz exemplifies human self-understanding in the interface between the visual and the linguistic. The content of the imago Dei cannot be defined apart from the image......How can we, in our times, understand the biblical concept that human beings have been created in the image of an invisible God? This is a perennial but increasingly pressing question that lies at the heart of theological anthropology. Humanity in God's Image: An Interdisciplinary Exploration...

  6. Human-Robot Planetary Exploration Teams

    Science.gov (United States)

    Tyree, Kimberly

    2004-01-01

    The EVA Robotic Assistant (ERA) project at NASA Johnson Space Center studies human-robot interaction and robotic assistance for future human planetary exploration. Over the past four years, the ERA project has been performing field tests with one or more four-wheeled robotic platforms and one or more space-suited humans. These tests have provided experience in how robots can assist humans, how robots and humans can communicate in remote environments, and what combination of humans and robots works best for different scenarios. The most efficient way to understand what tasks human explorers will actually perform, and how robots can best assist them, is to have human explorers and scientists go and explore in an outdoor, planetary-relevant environment, with robots to demonstrate what they are capable of, and roboticists to observe the results. It can be difficult to have a human expert itemize all the needed tasks required for exploration while sitting in a lab: humans do not always remember all the details, and experts in one arena may not even recognize that the lower level tasks they take for granted may be essential for a roboticist to know about. Field tests thus create conditions that more accurately reveal missing components and invalid assumptions, as well as allow tests and comparisons of new approaches and demonstrations of working systems. We have performed field tests in our local rock yard, in several locations in the Arizona desert, and in the Utah desert. We have tested multiple exploration scenarios, such as geological traverses, cable or solar panel deployments, and science instrument deployments. The configuration of our robot can be changed, based on what equipment is needed for a given scenario, and the sensor mast can even be placed on one of two robot bases, each with different motion capabilities. The software architecture of our robot is also designed to be as modular as possible, to allow for hardware and configuration changes. Two focus

  7. Interaction Challenges in Human-Robot Space Exploration

    Science.gov (United States)

    Fong, Terrence; Nourbakhsh, Illah

    2005-01-01

    In January 2004, NASA established a new, long-term exploration program to fulfill the President's Vision for U.S. Space Exploration. The primary goal of this program is to establish a sustained human presence in space, beginning with robotic missions to the Moon in 2008, followed by extended human expeditions to the Moon as early as 2015. In addition, the program places significant emphasis on the development of joint human-robot systems. A key difference from previous exploration efforts is that future space exploration activities must be sustainable over the long-term. Experience with the space station has shown that cost pressures will keep astronaut teams small. Consequently, care must be taken to extend the effectiveness of these astronauts well beyond their individual human capacity. Thus, in order to reduce human workload, costs, and fatigue-driven error and risk, intelligent robots will have to be an integral part of mission design.

  8. Human-centred automation: an explorative study

    International Nuclear Information System (INIS)

    Hollnagel, Erik; Miberg, Ann Britt

    1999-05-01

    The purpose of the programme activity on human-centred automation at the HRP is to develop knowledge (in the form of models and theories) and tools (in the form of techniques and simulators) to support design of automation that ensures effective human performance and comprehension. This report presents the work done on both the analytical and experimental side of this project. The analytical work has surveyed common definitions of automation and traditional design principles. A general finding is that human-centred automation usually is defined in terms of what it is not. This is partly due to a lack of adequate models and of human-automation interaction. Another result is a clarification of the consequences of automation, in particular with regard to situation awareness and workload. The experimental work has taken place as an explorative experiment in HAMMLAB in collaboration with IPSN (France). The purpose of this experiment was to increase the understanding of how automation influences operator performance in NPP control rooms. Two different types of automation (extensive and limited) were considered in scenarios having two different degrees of complexity (high and low), and involving diagnostic and procedural tasks. Six licensed NPP crews from the NPP at Loviisa, Finland, participated in the experiment. The dependent variables applied were plant performance, operator performance, self-rated crew performance, situation awareness, workload, and operator trust in the automation. The results from the diagnostic scenarios indicated that operators' judgement of crew efficiency was related to their level of trust in the automation, and further that operators trusted automation least and rated crew performance lowest in situations where crew performance was efficient and vice versa. The results from procedural scenarios indicated that extensive automation efficiently supported operators' performance, and further that operator' judgement of crew performance efficiency

  9. Defense Human Resources Activity > PERSEREC

    Science.gov (United States)

    Skip to main content (Press Enter). Toggle navigation Defense Human Resources Activity Search Search Defense Human Resources Activity: Search Search Defense Human Resources Activity: Search Defense Human Resources Activity U.S. Department of Defense Defense Human Resources Activity Overview

  10. Scientific field training for human planetary exploration

    Science.gov (United States)

    Lim, D. S. S.; Warman, G. L.; Gernhardt, M. L.; McKay, C. P.; Fong, T.; Marinova, M. M.; Davila, A. F.; Andersen, D.; Brady, A. L.; Cardman, Z.; Cowie, B.; Delaney, M. D.; Fairén, A. G.; Forrest, A. L.; Heaton, J.; Laval, B. E.; Arnold, R.; Nuytten, P.; Osinski, G.; Reay, M.; Reid, D.; Schulze-Makuch, D.; Shepard, R.; Slater, G. F.; Williams, D.

    2010-05-01

    Forthcoming human planetary exploration will require increased scientific return (both in real time and post-mission), longer surface stays, greater geographical coverage, longer and more frequent EVAs, and more operational complexities than during the Apollo missions. As such, there is a need to shift the nature of astronauts' scientific capabilities to something akin to an experienced terrestrial field scientist. To achieve this aim, the authors present a case that astronaut training should include an Apollo-style curriculum based on traditional field school experiences, as well as full immersion in field science programs. Herein we propose four Learning Design Principles (LDPs) focused on optimizing astronaut learning in field science settings. The LDPs are as follows: LDP#1: Provide multiple experiences: varied field science activities will hone astronauts' abilities to adapt to novel scientific opportunities LDP#2: Focus on the learner: fostering intrinsic motivation will orient astronauts towards continuous informal learning and a quest for mastery LDP#3: Provide a relevant experience - the field site: field sites that share features with future planetary missions will increase the likelihood that astronauts will successfully transfer learning LDP#4: Provide a social learning experience - the field science team and their activities: ensuring the field team includes members of varying levels of experience engaged in opportunities for discourse and joint problem solving will facilitate astronauts' abilities to think and perform like a field scientist. The proposed training program focuses on the intellectual and technical aspects of field science, as well as the cognitive manner in which field scientists experience, observe and synthesize their environment. The goal of the latter is to help astronauts develop the thought patterns and mechanics of an effective field scientist, thereby providing a broader base of experience and expertise than could be achieved

  11. Graphical Visualization of Human Exploration Capabilities

    Science.gov (United States)

    Rodgers, Erica M.; Williams-Byrd, Julie; Arney, Dale C.; Simon, Matthew A.; Williams, Phillip A.; Barsoum, Christopher; Cowan, Tyler; Larman, Kevin T.; Hay, Jason; Burg, Alex

    2016-01-01

    NASA's pioneering space strategy will require advanced capabilities to expand the boundaries of human exploration on the Journey to Mars (J2M). The Evolvable Mars Campaign (EMC) architecture serves as a framework to identify critical capabilities that need to be developed and tested in order to enable a range of human exploration destinations and missions. Agency-wide System Maturation Teams (SMT) are responsible for the maturation of these critical exploration capabilities and help formulate, guide and resolve performance gaps associated with the EMC-identified capabilities. Systems Capability Organization Reporting Engine boards (SCOREboards) were developed to integrate the SMT data sets into cohesive human exploration capability stories that can be used to promote dialog and communicate NASA's exploration investments. Each SCOREboard provides a graphical visualization of SMT capability development needs that enable exploration missions, and presents a comprehensive overview of data that outlines a roadmap of system maturation needs critical for the J2M. SCOREboards are generated by a computer program that extracts data from a main repository, sorts the data based on a tiered data reduction structure, and then plots the data according to specified user inputs. The ability to sort and plot varying data categories provides the flexibility to present specific SCOREboard capability roadmaps based on customer requests. This paper presents the development of the SCOREboard computer program and shows multiple complementary, yet different datasets through a unified format designed to facilitate comparison between datasets. Example SCOREboard capability roadmaps are presented followed by a discussion of how the roadmaps are used to: 1) communicate capability developments and readiness of systems for future missions, and 2) influence the definition of NASA's human exploration investment portfolio through capability-driven processes. The paper concludes with a description

  12. Understanding predictability and exploration in human mobility

    DEFF Research Database (Denmark)

    Cuttone, Andrea; Jørgensen, Sune Lehmann; González, Marta C.

    2018-01-01

    Predictive models for human mobility have important applications in many fields including traffic control, ubiquitous computing, and contextual advertisement. The predictive performance of models in literature varies quite broadly, from over 90% to under 40%. In this work we study which underlying...... strong influence on the accuracy of prediction. Finally we reveal that the exploration of new locations is an important factor in human mobility, and we measure that on average 20-25% of transitions are to new places, and approx. 70% of locations are visited only once. We discuss how these mechanisms...... are important factors limiting our ability to predict human mobility....

  13. Human Exploration Science Office (KX) Overview

    Science.gov (United States)

    Calhoun, Tracy A.

    2014-01-01

    The Human Exploration Science Office supports human spaceflight, conducts research, and develops technology in the areas of space orbital debris, hypervelocity impact technology, image science and analysis, remote sensing, imagery integration, and human and robotic exploration science. NASA's Orbital Debris Program Office (ODPO) resides in the Human Exploration Science Office. ODPO provides leadership in orbital debris research and the development of national and international space policy on orbital debris. The office is recognized internationally for its measurement and modeling of the debris environment. It takes the lead in developing technical consensus across U.S. agencies and other space agencies on debris mitigation measures to protect users of the orbital environment. The Hypervelocity Impact Technology (HVIT) project evaluates the risks to spacecraft posed by micrometeoroid and orbital debris (MMOD). HVIT facilities at JSC and White Sands Test Facility (WSTF) use light gas guns, diagnostic tools, and high-speed imagery to quantify the response of spacecraft materials to MMOD impacts. Impact tests, with debris environment data provided by ODPO, are used by HVIT to predict risks to NASA and commercial spacecraft. HVIT directly serves NASA crew safety with MMOD risk assessments for each crewed mission and research into advanced shielding design for future missions. The Image Science and Analysis Group (ISAG) supports the International Space Station (ISS) and commercial spaceflight through the design of imagery acquisition schemes (ground- and vehicle-based) and imagery analyses for vehicle performance assessments and mission anomaly resolution. ISAG assists the Multi-Purpose Crew Vehicle (MPCV) Program in the development of camera systems for the Orion spacecraft that will serve as data sources for flight test objectives that lead to crewed missions. The multi-center Imagery Integration Team is led by the Human Exploration Science Office and provides

  14. INTEGRITY -- Integrated Human Exploration Mission Simulation Facility

    Science.gov (United States)

    Henninger, D.; Tri, T.; Daues, K.

    It is proposed to develop a high -fidelity ground facil ity to carry out long-duration human exploration mission simulations. These would not be merely computer simulations - they would in fact comprise a series of actual missions that just happen to stay on earth. These missions would include all elements of an actual mission, using actual technologies that would be used for the real mission. These missions would also include such elements as extravehicular activities, robotic systems, telepresence and teleoperation, surface drilling technology--all using a simulated planetary landscape. A sequence of missions would be defined that get progressively longer and more robust, perhaps a series of five or six missions over a span of 10 to 15 years ranging in durat ion from 180 days up to 1000 days. This high-fidelity ground facility would operate hand-in-hand with a host of other terrestrial analog sites such as the Antarctic, Haughton Crater, and the Arizona desert. Of course, all of these analog mission simulations will be conducted here on earth in 1-g, and NASA will still need the Shuttle and ISS to carry out all the microgravity and hypogravity science experiments and technology validations. The proposed missions would have sufficient definition such that definitive requirements could be derived from them to serve as direction for all the program elements of the mission. Additionally, specific milestones would be established for the "launch" date of each mission so that R&D programs would have both good requirements and solid milestones from which to build their implementation plans. Mission aspects that could not be directly incorporated into the ground facility would be simulated via software. New management techniques would be developed for evaluation in this ground test facility program. These new techniques would have embedded metrics which would allow them to be continuously evaluated and adjusted so that by the time the sequence of missions is completed

  15. The Value of Humans in the Biological Exploration of Space

    Science.gov (United States)

    Cockell, C. S.

    2004-06-01

    Regardless of the discovery of life on Mars, or of "no apparent life" on Mars, the questions that follow will provide a rich future for biological exploration. Extraordinary pattern recognition skills, decadal assimilation of data and experience, and rapid sample acquisition are just three of the characteristics that make humans the best means we have to explore the biological potential of Mars and other planetary surfaces. I make the case that instead of seeing robots as in conflict, or even in support, of human exploration activity, from the point of view of scientific data gathering and analysis, we should view humans as the most powerful robots we have, thus removing the separation that dogs discussions on the exploration of space. The narrow environmental requirements of humans, although imposing constraints on the life support systems required, is more than compensated for by their capabilities in biological exploration. I support this view with an example of the "Christmas present effect," a simple demonstration of human data and pattern recognition capabilities.

  16. Human exploration of NEA: why and how?

    Science.gov (United States)

    Viscio, M. A.; Casacci, C.; Ferro, C.

    The human exploration of multiple deep space destinations, and among them Near Earth Asteroids (NEA), in view of the final challenge of sending astronauts to Mars, represents a current and consistent study domain. NEAs represent interesting targets, not only for the high level scientific return of such missions, but also for advanced technologies demonstration. Accordingly, the NEA mission described in this paper is conceived as an intermediate step before a human mission to the Red Planet and, in this regard, several technologies required for Mars are implemented, in order to test and validate them in significant environment, but at a closer and easier destination. Another crucial aspect to be considered, when dealing with asteroids, is related to planetary defense: even if the probability of an impact with the Earth is very low, this possibility does actually exist. A human mission as the one described in this paper would represent a chance for the development and test of technologies and techniques to be used for asteroid collision avoidance. The paper starts discussing the main objectives of a NEA mission, highlighting the benefits of the human presence. A reference human mission is then described, in terms of strategy, architecture and concept of operations, with particular attention to NEA collision avoidance issue. In the last part, the idea of exploiting virtual reality in support of the mission definition and execution is discussed.

  17. Exploring Data in Human Resources Big Data

    Directory of Open Access Journals (Sweden)

    Adela BARA

    2016-01-01

    Full Text Available Nowadays, social networks and informatics technologies and infrastructures are constantly developing and affect each other. In this context, the HR recruitment process became complex and many multinational organizations have encountered selection issues. The objective of the paper is to develop a prototype system for assisting the selection of candidates for an intelligent management of human resources. Such a system can be a starting point for the efficient organization of semi-structured and unstructured data on recruitment activities. The article extends the research presented at the 14th International Conference on Informatics in Economy (IE 2015 in the scientific paper "Big Data challenges for human resources management".

  18. Modeling Operations Costs for Human Exploration Architectures

    Science.gov (United States)

    Shishko, Robert

    2013-01-01

    Operations and support (O&S) costs for human spaceflight have not received the same attention in the cost estimating community as have development costs. This is unfortunate as O&S costs typically comprise a majority of life-cycle costs (LCC) in such programs as the International Space Station (ISS) and the now-cancelled Constellation Program. Recognizing this, the Constellation Program and NASA HQs supported the development of an O&S cost model specifically for human spaceflight. This model, known as the Exploration Architectures Operations Cost Model (ExAOCM), provided the operations cost estimates for a variety of alternative human missions to the moon, Mars, and Near-Earth Objects (NEOs) in architectural studies. ExAOCM is philosophically based on the DoD Architecture Framework (DoDAF) concepts of operational nodes, systems, operational functions, and milestones. This paper presents some of the historical background surrounding the development of the model, and discusses the underlying structure, its unusual user interface, and lastly, previous examples of its use in the aforementioned architectural studies.

  19. Object texture recognition by dynamic tactile sensing using active exploration

    DEFF Research Database (Denmark)

    Drimus, Alin; Børlum Petersen, Mikkel; Bilberg, Arne

    with a dynamic tactile transducer based on polyvinylidene fluoride (PVDF) piezoelectric film. Different test surfaces are actively explored and the signal from the sensor is used for feature extraction, which is subsequently used for classification. A comparison between the significance of different extracted......For both humans and robots, tactile sensing is important for interaction with the environment: it is the core sensing used for exploration and manipulation of objects. In this paper, we present a method for determining object texture by active exploration with a robotic fingertip equipped...

  20. Exploring Human Cognition Using Large Image Databases.

    Science.gov (United States)

    Griffiths, Thomas L; Abbott, Joshua T; Hsu, Anne S

    2016-07-01

    Most cognitive psychology experiments evaluate models of human cognition using a relatively small, well-controlled set of stimuli. This approach stands in contrast to current work in neuroscience, perception, and computer vision, which have begun to focus on using large databases of natural images. We argue that natural images provide a powerful tool for characterizing the statistical environment in which people operate, for better evaluating psychological theories, and for bringing the insights of cognitive science closer to real applications. We discuss how some of the challenges of using natural images as stimuli in experiments can be addressed through increased sample sizes, using representations from computer vision, and developing new experimental methods. Finally, we illustrate these points by summarizing recent work using large image databases to explore questions about human cognition in four different domains: modeling subjective randomness, defining a quantitative measure of representativeness, identifying prior knowledge used in word learning, and determining the structure of natural categories. Copyright © 2016 Cognitive Science Society, Inc.

  1. NASA Technology Area 07: Human Exploration Destination Systems Roadmap

    Science.gov (United States)

    Kennedy, Kriss J.; Alexander, Leslie; Landis, Rob; Linne, Diane; Mclemore, Carole; Santiago-Maldonado, Edgardo; Brown, David L.

    2011-01-01

    This paper gives an overview of the National Aeronautics and Space Administration (NASA) Office of Chief Technologist (OCT) led Space Technology Roadmap definition efforts. This paper will given an executive summary of the technology area 07 (TA07) Human Exploration Destination Systems (HEDS). These are draft roadmaps being reviewed and updated by the National Research Council. Deep-space human exploration missions will require many game changing technologies to enable safe missions, become more independent, and enable intelligent autonomous operations and take advantage of the local resources to become self-sufficient thereby meeting the goal of sustained human presence in space. Taking advantage of in-situ resources enhances and enables revolutionary robotic and human missions beyond the traditional mission architectures and launch vehicle capabilities. Mobility systems will include in-space flying, surface roving, and Extra-vehicular Activity/Extravehicular Robotics (EVA/EVR) mobility. These push missions will take advantage of sustainability and supportability technologies that will allow mission independence to conduct human mission operations either on or near the Earth, in deep space, in the vicinity of Mars, or on the Martian surface while opening up commercialization opportunities in low Earth orbit (LEO) for research, industrial development, academia, and entertainment space industries. The Human Exploration Destination Systems (HEDS) Technology Area (TA) 7 Team has been chartered by the Office of the Chief Technologist (OCT) to strategically roadmap technology investments that will enable sustained human exploration and support NASA s missions and goals for at least the next 25 years. HEDS technologies will enable a sustained human presence for exploring destinations such as remote sites on Earth and beyond including, but not limited to, LaGrange points, low Earth orbit (LEO), high Earth orbit (HEO), geosynchronous orbit (GEO), the Moon, near

  2. Principal tools for exploring the brain and mapping its activity

    International Nuclear Information System (INIS)

    Mazoyer, B.; Mashaal, M.

    1996-01-01

    The electro-encephalography (EEG), magneto-encephalography (MEG), scanner, positron computed tomography, single photon emission computed tomography (SPECT) and NMR imaging are the main methods used to explore human brain and to do a mapping of its activity. These methods are described into details (principle, visualization, uses, advantages, disadvantages). They can be useful to detect the possible anomalies of the human brain. (O.M.)

  3. Robots and Humans in Planetary Exploration: Working Together?

    Science.gov (United States)

    Landis, Geoffrey A.; Lyons, Valerie (Technical Monitor)

    2002-01-01

    Today's approach to human-robotic cooperation in planetary exploration focuses on using robotic probes as precursors to human exploration. A large portion of current NASA planetary surface exploration is focussed on Mars, and robotic probes are seen as precursors to human exploration in: Learning about operation and mobility on Mars; Learning about the environment of Mars; Mapping the planet and selecting landing sites for human mission; Demonstration of critical technology; Manufacture fuel before human presence, and emplace elements of human-support infrastructure

  4. ESA strategy for human exploration and the Lunar Lander Mission

    Science.gov (United States)

    Gardini, B.

    As part of ESAs Aurora Exploration programme, the Agency has defined, since 2001, a road map for exploration in which, alongside robotic exploration missions, the International Space Station (ISS) and the Moon play an essential role on the way to other destinations in the Solar System, ultimately to a human mission to Mars in a more distant future. In the frame of the Human Spaceflight programme the first European Lunar Lander Mission, with a launch date on 2018, has been defined, targeting the lunar South Pole region to capitalize on unique illumination conditions and provide the opportunity to carry out scientific investigations in a region of the Moon not explored so far. The Phase B1 industrial study, recently initiated, will consolidate the mission design and prepare the ground for the approval of the full mission development phase at the 2012 ESA Council at Ministerial. This paper describes the mission options which have been investigated in the past Phase A studies and presents the main activities foreseen in the Phase B1 to consolidate the mission design, including a robust bread-boards and technology development programme. In addition, the approach to overcoming the mission's major technical and environmental challenges and the activities to advance the definition of the payload elements will be described.

  5. Understanding Usability Work as a Human Activity

    DEFF Research Database (Denmark)

    Nørgaard, Mie

    Three core themes are explored in eight papers: Usability work as a human activity, usability practice and methods, and persuasiveness of evaluation results and feedback. We explore how usability work is much more than methods and work procedures, and argue that maturing our understanding...

  6. Exploring the HYDRAtion method for loading siRNA on liposomes: the interplay between stability and biological activity in human undiluted ascites fluid.

    Science.gov (United States)

    Dakwar, George R; Braeckmans, Kevin; Ceelen, Wim; De Smedt, Stefaan C; Remaut, Katrien

    2017-04-01

    Delivery of small interfering RNA (siRNA) is recently gaining tremendous attention for the treatment of ovarian cancer. The present study investigated the potential of different liposomal formulations composed of (2,3-dioleoyloxy-propyl)-trimethylammonium (DOTAP) and 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) encapsulating siRNA (hydration method) for their ability to knockdown luciferase (Luc) activity in human ovarian cancer SKOV-3 cells. Fluorescence single particle tracking (fSPT) and fluorescence correlation spectroscopy (FCS) in human-undiluted ascites fluid obtained from a peritoneal carcinomatosis patient revealed that cationic hydra-lipoplexes (HYDRA-LPXs) and HYDRA-LPXs decorated with stable DSPE-PEG (DSPE HYDRA-LPXs) showed high stability during at least 24 h. HYDRA-LPXs decorated with sheddable C8 and C16 PEG-Ceramides (Cer HYDRA-LPXs) resulted in rapid and premature release of siRNA already in the first hours. Despite their role in preventing aggregation in vivo, liposomes decorated with stable PEG residues resulted in a poor transfection compared to the ones decorated with sheddable PEG residues in reduced serum conditions. Yet, the transfection efficiency of both Cer HYDRA-LPXs significantly decreased following 1 h of incubation in ascites fluid due to a drastic drop in the cellular uptake, while DSPE HYDRA-LPXs are still taken up by cells, but too stable to induce efficient gene silencing.

  7. Benefits of Microalgae for Human Space Exploration

    Science.gov (United States)

    Verrecchia, Angelique; Bebout, Brad M.; Murphy, Thomas

    2015-01-01

    Algae have long been known to offer a number of benefits to support long duration human space exploration. Algae contain proteins, essential amino acids, vitamins, and lipids needed for human consumption, and can be produced using waste streams, while consuming carbon dioxide, and producing oxygen. In comparison with higher plants, algae have higher growth rates, fewer environmental requirements, produce far less "waste" tissue, and are resistant to digestion and/or biodegradation. As an additional benefit, algae produce many components (fatty acids, H2, etc.) which are useful as biofuels. On Earth, micro-algae survive in many harsh environments including low humidity, extremes in temperature, pH, and as well as high salinity and solar radiation. Algae have been shown to survive inmicro-gravity, and can adapt to high and low light intensity while retaining their ability to perform nitrogen fixation and photosynthesis. Studies have demonstrated that some algae are resistant to the space radiation environment, including solar ultraviolet radiation. It remains to be experimentally demonstrated, however, that an algal-based system could fulfil the requirements for a space-based Bioregenerative Life Support System (BLSS) under comparable spaceflight power, mass, and environmental constraints. Two specific challenges facing algae cultivation in space are that (i) conventional growth platforms require large masses of water, which in turn require a large amount of propulsion fuel, and (ii) most nutrient delivery mechanisms (predominantly bubbling) are dependent on gravity. To address these challenges, we have constructed a low water biofilm based bioreactor whose operation is enabled by capillary forces. Preliminary characterization of this Surface Adhering BioReactor (SABR) suggests that it can serve as a platform for cultivating algae in space which requires about 10 times less mass than conventional reactors without sacrificing growth rate. Further work is necessary to

  8. Active Play: Exploring the Influences on Children's School Playground Activities

    Science.gov (United States)

    Hyndman, Brendon; Benson, Amanda; Telford, Amanda

    2016-01-01

    Because children spend so much of their time in schools, their playgrounds offer a good setting for promoting active play in young lives. Teachers, instead of considering active play a taxing demand on their busy day, have begun to develop an informal curriculum for it. The authors review the research on children's active play and explores its…

  9. Active Exploration for Robust Object Detection

    OpenAIRE

    Velez, Javier J.; Hemann, Garrett A.; Huang, Albert S.; Posner, Ingmar; Roy, Nicholas

    2011-01-01

    Today, mobile robots are increasingly expected to operate in ever more complex and dynamic environments. In order to carry out many of the higher-level tasks envisioned a semantic understanding of a workspace is pivotal. Here our field has benefited significantly from successes in machine learning and vision: applications in robotics of off-the-shelf object detectors are plentiful. This paper outlines an online, any-time planning framework enabling the active exploration of such detections. O...

  10. Exploring care for human service profession

    DEFF Research Database (Denmark)

    Høy, Bente

    2016-01-01

    maintain their dignity, it is important to explore, how dignity is maintained in such situations. Views of dignity and factors influencing dignity have been studied from both the nursing homes residents´ and the care providers´ perspective. However, little is known about how the residents’ experience...

  11. Exploring connections between trees and human health

    Science.gov (United States)

    Geoffrey Donovan; Marie. Oliver

    2014-01-01

    Humans have intuitively understood the value of trees to their physical and mental health since the beginning of recorded time. A scientist with the Pacific Northwest Research Station wondered if such a link could be scientifically validated. His research team took advantage of an infestation of emerald ash borer, an invasive pest that kills ash trees, to conduct a...

  12. Estimating the costs of human space exploration

    Science.gov (United States)

    Mandell, Humboldt C., Jr.

    1994-01-01

    The plan for NASA's new exploration initiative has the following strategic themes: (1) incremental, logical evolutionary development; (2) economic viability; and (3) excellence in management. The cost estimation process is involved with all of these themes and they are completely dependent upon the engineering cost estimator for success. The purpose is to articulate the issues associated with beginning this major new government initiative, to show how NASA intends to resolve them, and finally to demonstrate the vital importance of a leadership role by the cost estimation community.

  13. Environmental effects of human exploration of the Moon

    Science.gov (United States)

    Mendell, Wendell

    Aerospace engineers use the term Environment to designate a set of externally imposed bound-ary conditions under which a device must operate. Although the parameters may be time-varying, the engineer thinks of the operating environment as being fixed. Any effect the device might have on the environment generally is neglected. In the case where the device is intended to measure the environment, its effect on the measured quantities must be considered. For example, a magnetometer aboard a spacecraft must be extended on a boom to minimize the disturbing influence of the spacecraft on the magnetic field, particularly if the field is weak. In contrast, Environment has taken on political and even ethical connotations in modern Western society, referring to human-induced alterations to those aspects of the terrestrial environment that are required for a healthy and productive life. The so-called Green Movement takes preservation of the environment as its mantra. Scientists are at the center of the debate on environmental issues. However, the concern of scientists over irreversible consequences of hu-man activity extend beyond ecology to preservation of cultural artifacts and to effects that alter the ability to conduct investigations such as light pollution in astronomy. The policy of Planetary Protection applied to science and exploration missions to other bodies in the solar system arises from the concern for deleterious effects in terrestrial ecology from hypothetical extraterrestrial life forms as well as overprints of extraterrestrial environments by terrestrial biology. Some in the scientific community are advocating extension of the planetary protection concept beyond exobiology to include fragile planetary environments by might be permanently altered by human activity e.g., the lunar exosphere. Beyond the scientific community, some environmentalists argue against any changes to the Moon at all, including formation of new craters or the alteration of the natural

  14. Exploring Human Capital and Hybrid Entrepreneurship

    DEFF Research Database (Denmark)

    Klyver, Kim; Lomberg, Carina; Steffens, Paul

    2016-01-01

    ’s human capital influences entrepreneurial pursuits as a two stage process, first shaping whether nascent entrepreneurship and/or employment enters an individual’s consideration set when they are facing a career transition and second influencing the outcomes of entrepreneurial pursuits. Using a novel...... longitudinal dataset of individuals facing career transition as nascent entrepreneurs, job seekers or both, we find that while hybrid nascent entrepreneurship (trying to start a business while being employed) has a positive influence on outcomes, hybrid search (concurrent job search while trying to start...

  15. Radiation Environments for Future Human Exploration Throughout the Solar System.

    Science.gov (United States)

    Schwadron, N.; Gorby, M.; Linker, J.; Riley, P.; Torok, T.; Downs, C.; Spence, H. E.; Desai, M. I.; Mikic, Z.; Joyce, C. J.; Kozarev, K. A.; Townsend, L. W.; Wimmer-Schweingruber, R. F.

    2016-12-01

    Acute space radiation hazards pose one of the most serious risks to future human and robotic exploration. The ability to predict when and where large events will occur is necessary in order to mitigate their hazards. The largest events are usually associated with complex sunspot groups (also known as active regions) that harbor strong, stressed magnetic fields. Highly energetic protons accelerated very low in the corona by the passage of coronal mass ejection (CME)-driven compressions or shocks and from flares travel near the speed of light, arriving at Earth minutes after the eruptive event. Whether these particles actually reach Earth, the Moon, Mars (or any other point) depends on their transport in the interplanetary magnetic field and their magnetic connection to the shock. Recent contemporaneous observations during the largest events in almost a decade show the unique longitudinal distributions of this ionizing radiation broadly distributed from sources near the Sun and yet highly isolated during the passage of CME shocks. Over the last decade, we have observed space weather events as the solar wind exhibits extremely low densities and magnetic field strengths, representing states that have never been observed during the space age. The highly abnormal solar activity during cycles 23 and 24 has caused the longest solar minimum in over 80 years and continues into the unusually small solar maximum of cycle 24. As a result of the remarkably weak solar activity, we have also observed the highest fluxes of galactic cosmic rays in the space age and relatively small particle radiation events. We have used observations from LRO/CRaTER to examine the implications of these highly unusual solar conditions for human space exploration throughout the inner solar system. While these conditions are not a show-stopper for long-duration missions (e.g., to the Moon, an asteroid, or Mars), galactic cosmic ray radiation remains a significant and worsening factor that limits

  16. Exploring primary care activities in ACT teams.

    Science.gov (United States)

    Vanderlip, Erik R; Williams, Nancy A; Fiedorowicz, Jess G; Katon, Wayne

    2014-05-01

    People with serious mental illness often receive inadequate primary and preventive care services. Federal healthcare reform endorses team-based care that provides high quality primary and preventive care to at risk populations. Assertive community treatment (ACT) teams offer a proven, standardized treatment approach effective in improving mental health outcomes for the seriously mentally ill. Much is known about the effectiveness of ACT teams in improving mental health outcomes, but the degree to which medical care needs are addressed is not established. The purpose of this study was to explore the extent to which ACT teams address the physical health of the population they serve. ACT team leaders were invited to complete an anonymous, web-based survey to explore attitudes and activities involving the primary care needs of their clients. Information was collected regarding the use of health screening tools, physical health assessments, provision of medical care and collaboration with primary care systems. Data was analyzed from 127 team leaders across the country, of which 55 completed the entire survey. Nearly every ACT team leader believed ACT teams have a role in identifying and managing the medical co-morbidities of their clientele. ACT teams report participation in many primary care activities. ACT teams are providing a substantial amount of primary and preventive services to their population. The survey suggests standardization of physical health identification, management or referral processes within ACT teams may result in improved quality of medical care. ACT teams are in a unique position to improve physical health care by virtue of having medically trained staff and frequent, close contact with their clients.

  17. Human activity recognition and prediction

    CERN Document Server

    2016-01-01

    This book provides a unique view of human activity recognition, especially fine-grained human activity structure learning, human-interaction recognition, RGB-D data based action recognition, temporal decomposition, and causality learning in unconstrained human activity videos. The techniques discussed give readers tools that provide a significant improvement over existing methodologies of video content understanding by taking advantage of activity recognition. It links multiple popular research fields in computer vision, machine learning, human-centered computing, human-computer interaction, image classification, and pattern recognition. In addition, the book includes several key chapters covering multiple emerging topics in the field. Contributed by top experts and practitioners, the chapters present key topics from different angles and blend both methodology and application, composing a solid overview of the human activity recognition techniques. .

  18. Space Exploration as a Human Enterprise: The Scientific Interest

    Science.gov (United States)

    Sagan, Carl

    1973-01-01

    Presents examples which illustrate the importance of space exploration in diverse aspects of scientific knowledge. Indicates that human beings are today not wise enough to anticipate the practical benefits of planetary studies. (CC)

  19. Exploring Virtual Enterprises Using Activity Theory

    Directory of Open Access Journals (Sweden)

    Ronald Beckett

    2004-11-01

    Full Text Available From joint Industry – University research into the key success factors that sustain Virtual Enterprises (VE’s, it has been observed that conditions for the establishment of a VE do not necessarily sustain it. Transactions that are valued by the participants, a balance between similarity and complementarity attributes of the participants and effective utilisation of time are seen as important sustaining factors. Different communication and ICT tools are utilised in different circumstances, and successful collaborations develop formal or informal “rules” underlying their operation. Considering such attributes helps us understand what happens within a successful VE, but not necessarily how. Two case studies describing long-standing collaborations – one relating to a manufacturing network, and the other to a professional virtual community are presented. A third case study relating to the development of ICT tools to be used in a VE is also presented. Activity Theory is used as a framework for discussion of the organisational attributes associated with these cases and how they operate. It is suggested that exploration of the nature of tools, communities etc is helpful in understanding VE operations, and applied at multiple levels, Activity Theory is also useful in understanding the evolution of those tools, communities etc.

  20. Exploring differences among illegal activities in the Ugalla Game ...

    African Journals Online (AJOL)

    Exploring differences among illegal activities in the Ugalla Game Reserve of ... This study aimed to explore the differences among various illegal activities occurring in Ugalla Game Reserve, western Tanzania. ... AJOL African Journals Online.

  1. Project origami activities for exploring mathematics

    CERN Document Server

    Hull, Thomas

    2012-01-01

    IntroductionActivity 1 Folding Equilateral Triangles in a Square Activity 2 Origami Trigonometry Activity 3 Dividing a Length into Equal Nths: Fujimoto Approximation Activity 4 Dividing a Length into Equal Nths Exactly Activity 5 Origami Helix Activity 6 Folding a Parabola Activity 7 Can Origami Trisect an Angle?Activity 8 Solving Cubic Equations Activity 9 Lill's Method Activity 10 Folding Strips into Knots Activity 11 Haga's ""Origamics"" Activity 12 Modular Star Ring Activity 13 Folding a Butterfly Bomb Activity 14 Molly's Hexahedron Activity 15 Business Card Modulars Activity 16 Five Inter

  2. Human life support for advanced space exploration

    Science.gov (United States)

    Schwartzkopf, S. H.

    1997-01-01

    The requirements for a human life support system for long-duration space missions are reviewed. The system design of a controlled ecological life support system is briefly described, followed by a more detailed account of the study of the conceptual design of a Lunar Based CELSS. The latter is to provide a safe, reliable, recycling lunar base life support system based on a hybrid physicochemical/biological representative technology. The most important conclusion reached by this study is that implementation of a completely recycling CELSS approach for a lunar base is not only feasible, but eminently practical. On a cumulative launch mass basis, a 4-person Lunar Base CELSS would pay for itself in approximately 2.6 years relative to a physicochemical air/water recycling system with resupply of food from the Earth. For crew sizes of 30 and 100, the breakeven point would come even sooner, after 2.1 and 1.7 years, respectively, due to the increased mass savings that can be realized with the larger plant growth units. Two other conclusions are particularly important with regard to the orientation of future research and technology development. First, the mass estimates of the Lunar Base CELSS indicate that a primary design objective in implementing this kind of system must be to minimized the mass and power requirement of the food production plant growth units, which greatly surpass those of the other air and water recycling systems. Consequently, substantial research must be directed at identifying ways to produce food more efficiently. On the other hand, detailed studies to identify the best technology options for the other subsystems should not be expected to produce dramatic reductions in either mass or power requirement of a Lunar Base CELSS. The most crucial evaluation criterion must, therefore, be the capability for functional integration of these technologies into the ultimate design of the system. Secondly, this study illustrates that existing or near

  3. Human exploration and settlement of Mars - The roles of humans and robots

    Science.gov (United States)

    Duke, Michael B.

    1991-01-01

    The scientific objectives and strategies for human settlement on Mars are examined in the context of the Space Exploration Initiative (SEI). An integrated strategy for humans and robots in the exploration and settlement of Mars is examined. Such an effort would feature robotic, telerobotic, and human-supervised robotic phases.

  4. Human Activity in the Web

    OpenAIRE

    Radicchi, Filippo

    2009-01-01

    The recent information technology revolution has enabled the analysis and processing of large-scale datasets describing human activities. The main source of data is represented by the Web, where humans generally use to spend a relevant part of their day. Here we study three large datasets containing the information about Web human activities in different contexts. We study in details inter-event and waiting time statistics. In both cases, the number of subsequent operations which differ by ta...

  5. Seeking Asylum: Adolescents Explore the Crossroads of Human Rights Education and Cosmopolitan Critical Literacy

    Science.gov (United States)

    Dunkerly-Bean, Judith; Bean, Thomas; Alnajjar, Khaled

    2014-01-01

    The purpose of this study was to explore middle school (grade 6-8) students' understanding and interpretation of human rights issues with local and global implications as they engaged in the process of creating a film after reading print and multimedia texts and participating in human rights education activities. As the students explored…

  6. Crabby Interactions: Fifth Graders Explore Human Impact on the Blue Crab Population

    Science.gov (United States)

    Jeffery, Tonya D.; McCollough, Cherie A.; Moore, Kim

    2016-01-01

    This article describes a two-day lesson in which fifth-grade students took on the role of marine biology scientists, using their critical-thinking and problem-solving skills to explore human impact on the blue crab ecosystem. The purpose of "Crabby Interactions" was to help students understand the impact of human activities on the local…

  7. United States Human Access to Space, Exploration of the Moon and Preparation for Mars Exploration

    Science.gov (United States)

    Rhatigan, Jennifer L.

    2009-01-01

    In the past, men like Leonardo da Vinci and Jules Verne imagined the future and envisioned fantastic inventions such as winged flying machines, submarines, and parachutes, and posited human adventures like transoceanic flight and journeys to the Moon. Today, many of their ideas are reality and form the basis for our modern world. While individual visionaries like da Vinci and Verne are remembered for the accuracy of their predictions, today entire nations are involved in the process of envisioning and defining the future development of mankind, both on and beyond the Earth itself. Recently, Russian, European, and Chinese teams have all announced plans for developing their own next generation human space vehicles. The Chinese have announced their intention to conduct human lunar exploration, and have flown three crewed space missions since 2003, including a flight with three crew members to test their extravehicular (spacewalking) capabilities in September 2008. Very soon, the prestige, economic development, scientific discovery, and strategic security advantage historically associated with leadership in space exploration and exploitation may no longer be the undisputed province of the United States. Much like the sponsors of the seafaring explorers of da Vinci's age, we are motivated by the opportunity to obtain new knowledge and new resources for the growth and development of our own civilization. NASA's new Constellation Program, established in 2005, is tasked with maintaining the United States leadership in space, exploring the Moon, creating a sustained human lunar presence, and eventually extending human operations to Mars and beyond. Through 2008, the Constellation Program developed a full set of detailed program requirements and is now completing the preliminary design phase for the new Orion Crew Exploration Vehicle (CEV), the Ares I Crew Launch Vehicle, and the associated infrastructure necessary for humans to explore the Moon. Component testing is well

  8. Planetary Protection Issues in the Human Exploration of Mars

    Science.gov (United States)

    Criswell, Marvin E.; Race, M. S.; Rummel, J. D.; Baker, A.

    2005-01-01

    This workshop report, long delayed, is the first 21st century contribution to what will likely be a series of reports examining the effects of human exploration on the overall scientific study of Mars. The considerations of human-associated microbial contamination were last studied in a 1990 workshop ("Planetary Protection Issues and Future Mars Missions," NASA CP-10086, 1991), but the timing of that workshop allowed neither a careful examination of the full range of issues, nor an appreciation for the Mars that has been revealed by the Mars Global Surveyor and Mars Pathfinder missions. Future workshops will also have the advantage of Mars Odyssey, the Mars Exploration Rover missions, and ESA's Mars Express, but the Pingree Park workshop reported here had both the NCR's (1992) concern that "Missions carrying humans to Mars will contaminate the planet" and over a decade of careful study of human exploration objectives to guide them and to reconcile. A daunting challenge, and one that is not going to be simple (as the working title of this meeting, "When Ecologies Collide?" might suggest), it is clear that the planetary protection issues will have to be addressed to enable human explorers to safely and competently extend out knowledge about Mars, and its potential as a home for life whether martian or human.

  9. Automation and Robotics for Human Mars Exploration (AROMA)

    Science.gov (United States)

    Hofmann, Peter; von Richter, Andreas

    2003-01-01

    Automation and Robotics (A&R) systems are a key technology for Mars exploration. All over the world initiatives in this field aim at developing new A&R systems and technologies for planetary surface exploration. From December 2000 to February 2002 Kayser-Threde GmbH, Munich, Germany lead a study called AROMA (Automation and Robotics for Human Mars Exploration) under ESA contract in order to define a reference architecture of A&R elements in support of a human Mars exploration program. One of the goals of this effort is to initiate new developments and to maintain the competitiveness of European industry within this field. c2003 Published by Elsevier Science Ltd.

  10. Human telomerase activity regulation

    OpenAIRE

    Wojtyla, Aneta; Gladych, Marta; Rubis, Blazej

    2010-01-01

    Telomerase has been recognized as a relevant factor distinguishing cancer cells from normal cells. Thus, it has become a very promising target for anticancer therapy. The cell proliferative potential can be limited by replication end problem, due to telomeres shortening, which is overcome in cancer cells by telomerase activity or by alternative telomeres lengthening (ALT) mechanism. However, this multisubunit enzymatic complex can be regulated at various levels, including expression control b...

  11. Human haptic perception is interrupted by explorative stops of milliseconds

    Directory of Open Access Journals (Sweden)

    Martin eGrunwald

    2014-04-01

    Full Text Available Introduction: The explorative scanning movements of the hands have been compared to those of the eyes. The visual process is known to be composed of alternating phases of saccadic eye movements and fixation pauses. Descriptive results suggest that during the haptic exploration of objects short movement pauses occur as well. The goal of the present study was to detect these explorative stops (ES during one-handed and two-handed haptic explorations of various objects and patterns, and to measure their duration. Additionally, the associations between the following variables were analyzed: a between mean exploration time and duration of ES, b between certain stimulus features and ES frequency, and c the duration of ES during the course of exploration. Methods: Five different experiments were used. The first two experiments were classical recognition tasks of unknown haptic stimuli (A and of common objects (B. In experiment C space-position information of angle legs had to be perceived and reproduced. For experiments D and E the PHANToM haptic device was used for the exploration of virtual (D and real (E sunken reliefs. Results: In each experiment we observed explorative stops of different average durations. For experiment A: 329.50 ms, experiment B: 67.47 ms, experiment C: 189.92 ms, experiment D: 186.17 ms and experiment E: 140.02 ms. Significant correlations were observed between exploration time and the duration of the ES. Also, ES occurred more frequently, but not exclusively, at defined stimulus features like corners, curves and the endpoints of lines. However, explorative stops do not occur every time a stimulus feature is explored. Conclusions: We assume that ES are a general aspect of human haptic exploration processes. We have tried to interpret the occurrence and duration of ES with respect to the Hypotheses-Rebuild-Model and the Limited Capacity Control System theory.

  12. Overview of the Human Exploration Research Analog (HERA)

    Science.gov (United States)

    Neigut, J.

    2015-01-01

    In 2013, the Human Research Program at NASA began developing a new confinement analog specifically for conducting research to investigate the effects of confinement on the human system. The HERA (Human Exploration Research Analog) habitat has been used for both 7 and 14 day missions to date to examine and mitigate exploration risks to enable safe, reliable and productive human space exploration. This presentation will describe how the Flight Analogs Project developed the HERA facility and the infrastructure to suit investigator requirements for confinement research and in the process developed a new approach to analog utilization and a new state of the art analog facility. Details regarding HERA operations will be discussed including specifics on the mission simulation utilized for the current 14-day campaign, the specifics of the facility (total volume, overall size, hardware), and the capabilities available to researchers. The overall operational philosophy, mission fidelity including timeline, schedule pressures and cadence, and development and implementation of mission stressors will be presented. Research conducted to date in the HERA has addressed risks associated with behavioral health and performance, human physiology, as well as human factors. This presentation will conclude with a discussion of future research plans for the HERA, including infrastructure improvements and additional research capabilities planned for the upcoming 30-day missions in 2016.

  13. Comparison of Human Exploration Architecture and Campaign Approaches

    Science.gov (United States)

    Goodliff, Kandyce; Cirillo, William; Mattfeld, Bryan; Stromgren, Chel; Shyface, Hilary

    2015-01-01

    As part of an overall focus on space exploration, National Aeronautics and Space Administration (NASA) continues to evaluate potential approaches for sending humans beyond low Earth orbit (LEO). In addition, various external organizations are studying options for beyond LEO exploration. Recent studies include NASA's Evolvable Mars Campaign and Design Reference Architecture (DRA) 5.0, JPL's Minimal Mars Architecture; the Inspiration Mars mission; the Mars One campaign; and the Global Exploration Roadmap (GER). Each of these potential exploration constructs applies unique methods, architectures, and philosophies for human exploration. It is beneficial to compare potential approaches in order to better understand the range of options available for exploration. Since most of these studies were conducted independently, the approaches, ground rules, and assumptions used to conduct the analysis differ. In addition, the outputs and metrics presented for each construct differ substantially. This paper will describe the results of an effort to compare and contrast the results of these different studies under a common set of metrics. The paper will first present a summary of each of the proposed constructs, including a description of the overall approach and philosophy for exploration. Utilizing a common set of metrics for comparison, the paper will present the results of an evaluation of the potential benefits, critical challenges, and uncertainties associated with each construct. The analysis framework will include a detailed evaluation of key characteristics of each construct. These will include but are not limited to: a description of the technology and capability developments required to enable the construct and the uncertainties associated with these developments; an analysis of significant operational and programmatic risks associated with that construct; and an evaluation of the extent to which exploration is enabled by the construct, including the destinations

  14. Medical and technology requirements for human solar system exploration missions

    Science.gov (United States)

    Nicogossian, Arnauld; Harris, Leonard; Couch, Lana; Sulzman, Frank; Gaiser, Karen

    1989-01-01

    Measures that need to be taken to cope with the health problems posed by zero gravity and radiation in manned solar system exploration missions are discussed. The particular systems that will be used aboard Space Station Freedom are addressed, and relevant human factors problems are examined. The development of a controlled ecological life support system is addressed.

  15. Launch and Assembly Reliability Analysis for Human Space Exploration Missions

    Science.gov (United States)

    Cates, Grant; Gelito, Justin; Stromgren, Chel; Cirillo, William; Goodliff, Kandyce

    2012-01-01

    NASA's future human space exploration strategy includes single and multi-launch missions to various destinations including cis-lunar space, near Earth objects such as asteroids, and ultimately Mars. Each campaign is being defined by Design Reference Missions (DRMs). Many of these missions are complex, requiring multiple launches and assembly of vehicles in orbit. Certain missions also have constrained departure windows to the destination. These factors raise concerns regarding the reliability of launching and assembling all required elements in time to support planned departure. This paper describes an integrated methodology for analyzing launch and assembly reliability in any single DRM or set of DRMs starting with flight hardware manufacturing and ending with final departure to the destination. A discrete event simulation is built for each DRM that includes the pertinent risk factors including, but not limited to: manufacturing completion; ground transportation; ground processing; launch countdown; ascent; rendezvous and docking, assembly, and orbital operations leading up to trans-destination-injection. Each reliability factor can be selectively activated or deactivated so that the most critical risk factors can be identified. This enables NASA to prioritize mitigation actions so as to improve mission success.

  16. Human collective intelligence under dual exploration-exploitation dilemmas.

    Directory of Open Access Journals (Sweden)

    Wataru Toyokawa

    Full Text Available The exploration-exploitation dilemma is a recurrent adaptive problem for humans as well as non-human animals. Given a fixed time/energy budget, every individual faces a fundamental trade-off between exploring for better resources and exploiting known resources to optimize overall performance under uncertainty. Colonies of eusocial insects are known to solve this dilemma successfully via evolved coordination mechanisms that function at the collective level. For humans and other non-eusocial species, however, this dilemma operates within individuals as well as between individuals, because group members may be motivated to take excessive advantage of others' exploratory findings through social learning. Thus, even though social learning can reduce collective exploration costs, the emergence of disproportionate "information scroungers" may severely undermine its potential benefits. We investigated experimentally whether social learning opportunities might improve the performance of human participants working on a "multi-armed bandit" problem in groups, where they could learn about each other's past choice behaviors. Results showed that, even though information scroungers emerged frequently in groups, social learning opportunities reduced total group exploration time while increasing harvesting from better options, and consequentially improved collective performance. Surprisingly, enriching social information by allowing participants to observe others' evaluations of chosen options (e.g., Amazon's 5-star rating system in addition to choice-frequency information had a detrimental impact on performance compared to the simpler situation with only the choice-frequency information. These results indicate that humans groups can handle the fundamental "dual exploration-exploitation dilemmas" successfully, and that social learning about simple choice-frequencies can help produce collective intelligence.

  17. HUMAN ACTIVITY MONITORING USING SMARTPHONE

    OpenAIRE

    TOKALA, SAI SUJIT; ROKALA, RANADEEP

    2014-01-01

    The main aim of the project is to develop an algorithm which will classify the activity performed by a human who is carrying a smart phone. The day to day life made humans very busy at work and during daily activities, mostly elderly people who are at home have an important need to monitor their activity by others when they are alone, if they are inactive for a long time without movement, or in some situations like if they have fallen down, became unconscious for sometime or seized with a car...

  18. A review exploring biological activities of hydrazones

    Directory of Open Access Journals (Sweden)

    Garima Verma

    2014-01-01

    Full Text Available The development of novel compounds, hydrazones has shown that they possess a wide variety of biological activities viz. antimicrobial, anticonvulsant, antidepressant, anti-inflammatory, analgesic, antiplatelet, antimalarial, anticancer, antifungal, antitubercular, antiviral, cardio protective etc., Hydrazones/azomethines/imines possess-NHN = CH- and constitute an important class of compounds for new drug development. A number of researchers have synthesized and evaluated the biological activities of hydrazones. This review aims at highlighting the diverse biological activities of hydrazones.

  19. Strategic Implications of Human Exploration of Near-Earth Asteroids

    Science.gov (United States)

    Drake, Bret G.

    2011-01-01

    The current United States Space Policy [1] as articulated by the White House and later confirmed by the Congress [2] calls for [t]he extension of the human presence from low-Earth orbit to other regions of space beyond low-Earth orbit will enable missions to the surface of the Moon and missions to deep space destinations such as near-Earth asteroids and Mars. Human exploration of the Moon and Mars has been the focus of numerous exhaustive studies and planning, but missions to Near-Earth Asteroids (NEAs) has, by comparison, garnered relatively little attention in terms of mission and systems planning. This paper examines the strategic implications of human exploration of NEAs and how they can fit into the overall exploration strategy. This paper specifically addresses how accessible NEAs are in terms of mission duration, technologies required, and overall architecture construct. Example mission architectures utilizing different propulsion technologies such as chemical, nuclear thermal, and solar electric propulsion were formulated to determine resulting figures of merit including number of NEAs accessible, time of flight, mission mass, number of departure windows, and length of the launch windows. These data, in conjunction with what we currently know about these potential exploration targets (or need to know in the future), provide key insights necessary for future mission and strategic planning.

  20. Survey explores active tectonics in northeastern Caribbean

    Science.gov (United States)

    Carbó, A.; Córdoba, D.; Muñoz-Martín, A.; Granja, J.L.; Martín-Dávila, J.; Pazos, A.; Catalán, M.; Gómez, M.; ten Brink, Uri S.; von Hillebrandt, Christa; Payero, J.

    2005-01-01

    There is renewed interest in studying the active and complex northeastern Caribbean plate boundary to better understand subduction zone processes and for earthquake and tsunami hazard assessments [e.g., ten Brink and Lin, 2004; ten Brink et al., 2004; Grindlay et al., 2005]. To study the active tectonics of this plate boundary, the GEOPRICO-DO (Geological, Puerto Rico-Dominican) marine geophysical cruise, carried out between 28 March and 17 April 2005 (Figure 1), studied the active tectonics of this plate boundary.Initial findings from the cruise have revealed a large underwater landslide, and active faults on the seafloor (Figures 2a and 2c). These findings indicate that the islands within this region face a high risk from tsunami hazards, and that local governments should be alerted in order to develop and coordinate possible mitigation strategies.

  1. Exploring Representativeness and Informativeness for Active Learning.

    Science.gov (United States)

    Du, Bo; Wang, Zengmao; Zhang, Lefei; Zhang, Liangpei; Liu, Wei; Shen, Jialie; Tao, Dacheng

    2017-01-01

    How can we find a general way to choose the most suitable samples for training a classifier? Even with very limited prior information? Active learning, which can be regarded as an iterative optimization procedure, plays a key role to construct a refined training set to improve the classification performance in a variety of applications, such as text analysis, image recognition, social network modeling, etc. Although combining representativeness and informativeness of samples has been proven promising for active sampling, state-of-the-art methods perform well under certain data structures. Then can we find a way to fuse the two active sampling criteria without any assumption on data? This paper proposes a general active learning framework that effectively fuses the two criteria. Inspired by a two-sample discrepancy problem, triple measures are elaborately designed to guarantee that the query samples not only possess the representativeness of the unlabeled data but also reveal the diversity of the labeled data. Any appropriate similarity measure can be employed to construct the triple measures. Meanwhile, an uncertain measure is leveraged to generate the informativeness criterion, which can be carried out in different ways. Rooted in this framework, a practical active learning algorithm is proposed, which exploits a radial basis function together with the estimated probabilities to construct the triple measures and a modified best-versus-second-best strategy to construct the uncertain measure, respectively. Experimental results on benchmark datasets demonstrate that our algorithm consistently achieves superior performance over the state-of-the-art active learning algorithms.

  2. Solar Electric Propulsion Concepts for Human Space Exploration

    Science.gov (United States)

    Mercer, Carolyn R.; Mcguire, Melissa L.; Oleson, Steven R.; Barrett, Michael J.

    2016-01-01

    Advances in solar array and electric thruster technologies now offer the promise of new, very capable space transportation systems that will allow us to cost effectively explore the solar system. NASA has developed numerous solar electric propulsion spacecraft concepts with power levels ranging from tens to hundreds of kilowatts for robotic and piloted missions to asteroids and Mars. This paper describes nine electric and hybrid solar electric/chemical propulsion concepts developed over the last 5 years and discusses how they might be used for human exploration of the inner solar system.

  3. Unmanned systems to support the human exploration of Mars

    Science.gov (United States)

    Gage, Douglas W.

    2010-04-01

    Robots and other unmanned systems will play many critical roles in support of a human presence on Mars, including surveying candidate landing sites, locating ice and mineral resources, establishing power and other infrastructure, performing construction tasks, and transporting equipment and supplies. Many of these systems will require much more strength and power than exploration rovers. The presence of humans on Mars will permit proactive maintenance and repair, and allow teleoperation and operator intervention, supporting multiple dynamic levels of autonomy, so the critical challenges to the use of unmanned systems will occur before humans arrive on Mars. Nevertheless, installed communications and navigation infrastructure should be able to support structured and/or repetitive operations (such as excavation, drilling, or construction) within a "familiar" area with an acceptable level of remote operator intervention. This paper discusses some of the factors involved in developing and deploying unmanned systems to make humans' time on Mars safer and more productive, efficient, and enjoyable.

  4. Comparison of Propulsion Options for Human Exploration of Mars

    Science.gov (United States)

    Drake, Bret G.; McGuire, Melissa L.; McCarty, Steven L.

    2018-01-01

    NASA continues to advance plans to extend human presence beyond low-Earth orbit leading to human exploration of Mars. The plans being laid out follow an incremental path, beginning with initial flight tests followed by deployment of a Deep Space Gateway (DSG) in cislunar space. This Gateway, will serve as the initial transportation node for departing and returning Mars spacecraft. Human exploration of Mars represents the next leap for humankind because it will require leaving Earth on a long mission with very limited return, rescue, or resupply capabilities. Although Mars missions are long, approaches and technologies are desired which can reduce the time that the crew is away from Earth. This paper builds off past analyses of NASA's exploration strategy by providing more detail on the performance of alternative in-space transportation options with an emphasis on reducing total mission duration. Key options discussed include advanced chemical, nuclear thermal, nuclear electric, solar electric, as well as an emerging hybrid propulsion system which utilizes a combination of both solar electric and chemical propulsion.

  5. Intelligent (Autonomous) Power Controller Development for Human Deep Space Exploration

    Science.gov (United States)

    Soeder, James; Raitano, Paul; McNelis, Anne

    2016-01-01

    As NASAs Evolvable Mars Campaign and other exploration initiatives continue to mature they have identified the need for more autonomous operations of the power system. For current human space operations such as the International Space Station, the paradigm is to perform the planning, operation and fault diagnosis from the ground. However, the dual problems of communication lag as well as limited communication bandwidth beyond GEO synchronous orbit, underscore the need to change the operation methodology for human operation in deep space. To address this need, for the past several years the Glenn Research Center has had an effort to develop an autonomous power controller for human deep space vehicles. This presentation discusses the present roadmap for deep space exploration along with a description of conceptual power system architecture for exploration modules. It then contrasts the present ground centric control and management architecture with limited autonomy on-board the spacecraft with an advanced autonomous power control system that features ground based monitoring with a spacecraft mission manager with autonomous control of all core systems, including power. It then presents a functional breakdown of the autonomous power control system and examines its operation in both normal and fault modes. Finally, it discusses progress made in the development of a real-time power system model and how it is being used to evaluate the performance of the controller and well as using it for verification of the overall operation.

  6. Human Exploration and Development in the Solar System

    Science.gov (United States)

    Mendell, Wendell

    2017-05-01

    Emergence of ballistic missile technology after the Second World War enabled human flight into Earth's orbit, fueling the imagination of those fascinated with science, technology, exploration, and adventure. The performance of astronauts in the early flights assuaged concerns about the functioning of "the human system" in the absence of normal gravity. However, researchers in space medicine have observed degradation of crews after longer exposure to the space environment and have developed countermeasures for most of them, although significant challenges remain. With the dawn of the 21st century, well-financed and technically competent commercial entities began to provide more affordable alternatives to historically expensive and risk-averse government-funded programs. Space's growing accessibility has encouraged entrepreneurs to pursue plans for potentially autarkic communities beyond Earth, exploiting natural resources on other worlds. Should such dreams prove to be technically and economically feasible, a new era will open for humanity with concomitant societal issues of a revolutionary nature.

  7. Surface Support Systems for Co-Operative and Integrated Human/Robotic Lunar Exploration

    Science.gov (United States)

    Mueller, Robert P.

    2006-01-01

    Human and robotic partnerships to realize space goals can enhance space missions and provide increases in human productivity while decreasing the hazards that the humans are exposed to. For lunar exploration, the harsh environment of the moon and the repetitive nature of the tasks involved with lunar outpost construction, maintenance and operation as well as production tasks associated with in-situ resource utilization, make it highly desirable to use robotic systems in co-operation with human activity. A human lunar outpost is functionally examined and concepts for selected human/robotic tasks are discussed in the context of a lunar outpost which will enable the presence of humans on the moon for extended periods of time.

  8. Scaling behavior of online human activity

    Science.gov (United States)

    Zhao, Zhi-Dan; Cai, Shi-Min; Huang, Junming; Fu, Yan; Zhou, Tao

    2012-11-01

    The rapid development of the Internet technology enables humans to explore the web and record the traces of online activities. From the analysis of these large-scale data sets (i.e., traces), we can get insights about the dynamic behavior of human activity. In this letter, the scaling behavior and complexity of human activity in the e-commerce, such as music, books, and movies rating, are comprehensively investigated by using the detrended fluctuation analysis technique and the multiscale entropy method. Firstly, the interevent time series of rating behaviors of these three types of media show similar scaling properties with exponents ranging from 0.53 to 0.58, which implies that the collective behaviors of rating media follow a process embodying self-similarity and long-range correlation. Meanwhile, by dividing the users into three groups based on their activities (i.e., rating per unit time), we find that the scaling exponents of the interevent time series in the three groups are different. Hence, these results suggest that a stronger long-range correlations exist in these collective behaviors. Furthermore, their information complexities vary in the three groups. To explain the differences of the collective behaviors restricted to the three groups, we study the dynamic behavior of human activity at the individual level, and find that the dynamic behaviors of a few users have extremely small scaling exponents associated with long-range anticorrelations. By comparing the interevent time distributions of four representative users, we can find that the bimodal distributions may bring forth the extraordinary scaling behaviors. These results of the analysis of the online human activity in the e-commerce may not only provide insight into its dynamic behaviors but may also be applied to acquire potential economic interest.

  9. Developing Humanities Collections in the Digital Age: Exploring Humanities Faculty Engagement with Electronic and Print Resources

    Science.gov (United States)

    Kachaluba, Sarah Buck; Brady, Jessica Evans; Critten, Jessica

    2014-01-01

    This article is based on quantitative and qualitative research examining humanities scholars' understandings of the advantages and disadvantages of print versus electronic information resources. It explores how humanities' faculty members at Florida State University (FSU) use print and electronic resources, as well as how they perceive these…

  10. Oxytocin modulates human communication by enhancing cognitive exploration.

    Science.gov (United States)

    de Boer, Miriam; Kokal, Idil; Blokpoel, Mark; Liu, Rui; Stolk, Arjen; Roelofs, Karin; van Rooij, Iris; Toni, Ivan

    2017-12-01

    Oxytocin is a neuropeptide known to influence how humans share material resources. Here we explore whether oxytocin influences how we share knowledge. We focus on two distinguishing features of human communication, namely the ability to select communicative signals that disambiguate the many-to-many mappings that exist between a signal's form and meaning, and adjustments of those signals to the presumed cognitive characteristics of the addressee ("audience design"). Fifty-five males participated in a randomized, double-blind, placebo controlled experiment involving the intranasal administration of oxytocin. The participants produced novel non-verbal communicative signals towards two different addressees, an adult or a child, in an experimentally-controlled live interactive setting. We found that oxytocin administration drives participants to generate signals of higher referential quality, i.e. signals that disambiguate more communicative problems; and to rapidly adjust those communicative signals to what the addressee understands. The combined effects of oxytocin on referential quality and audience design fit with the notion that oxytocin administration leads participants to explore more pervasively behaviors that can convey their intention, and diverse models of the addressees. These findings suggest that, besides affecting prosocial drive and salience of social cues, oxytocin influences how we share knowledge by promoting cognitive exploration. Copyright © 2017 Elsevier Ltd. All rights reserved.

  11. A Situation Awareness Assistant for Human Deep Space Exploration

    Science.gov (United States)

    Boy, Guy A.; Platt, Donald

    2013-01-01

    This paper presents the development and testing of a Virtual Camera (VC) system to improve astronaut and mission operations situation awareness while exploring other planetary bodies. In this embodiment, the VC is implemented using a tablet-based computer system to navigate through inter active database application. It is claimed that the advanced interaction media capability of the VC can improve situation awareness as the distribution of hu man space exploration roles change in deep space exploration. The VC is being developed and tested for usability and capability to improve situation awareness. Work completed thus far as well as what is needed to complete the project will be described. Planned testing will also be described.

  12. The effect of atomoxetine on random and directed exploration in humans.

    Science.gov (United States)

    Warren, Christopher M; Wilson, Robert C; van der Wee, Nic J; Giltay, Eric J; van Noorden, Martijn S; Cohen, Jonathan D; Nieuwenhuis, Sander

    2017-01-01

    The adaptive regulation of the trade-off between pursuing a known reward (exploitation) and sampling lesser-known options in search of something better (exploration) is critical for optimal performance. Theory and recent empirical work suggest that humans use at least two strategies for solving this dilemma: a directed strategy in which choices are explicitly biased toward information seeking, and a random strategy in which decision noise leads to exploration by chance. Here we examined the hypothesis that random exploration is governed by the neuromodulatory locus coeruleus-norepinephrine system. We administered atomoxetine, a norepinephrine transporter blocker that increases extracellular levels of norepinephrine throughout the cortex, to 22 healthy human participants in a double-blind crossover design. We examined the effect of treatment on performance in a gambling task designed to produce distinct measures of directed exploration and random exploration. In line with our hypothesis we found an effect of atomoxetine on random, but not directed exploration. However, contrary to expectation, atomoxetine reduced rather than increased random exploration. We offer three potential explanations of our findings, involving the non-linear relationship between tonic NE and cognitive performance, the interaction of atomoxetine with other neuromodulators, and the possibility that atomoxetine affected phasic norepinephrine activity more so than tonic norepinephrine activity.

  13. Physical activity and human health

    Directory of Open Access Journals (Sweden)

    Paulina Wojciechowska

    2015-01-01

    Full Text Available Introduction: The dynamic development of the automotive industry, transport, and the media means that human life has become much easier. At the same time, the comfortable living conditions have decreased physical activity. Biologically conditioned, the need of activity has been minimised by the ever-increasing pace of life. As a result, it may lead to the loss of physical and mental health. Active recreation is not only an excellent source of activity, but also a source of satisfaction. Youths and adults should therefore spend their free time primarily on various forms of physical activity. Aim of the research : To evaluate the physical fitness of students who regularly practice physical exercise, those who occasionally practice, and those not practicing any form of physical activity. Material and methods : In the research we used a questionnaire of the Ruffier test and an orthostatic test. The study involved a group of 15 people aged 20–25 years. Participation in the study was entirely voluntary and anonymous. The study group consisted only of women. Results obtained from the questionnaire survey were fully reflected during exercise tests performed. Results and conclusions: Only regularly practiced physical activity has an effect on our body. Regular exercise increases our body’s physical capacity. Activity is the best means of prevention of lifestyle diseases. Youths and adults should spend their free time mainly doing various forms of physical activity.

  14. Interactive Exploration Robots: Human-Robotic Collaboration and Interactions

    Science.gov (United States)

    Fong, Terry

    2017-01-01

    For decades, NASA has employed different operational approaches for human and robotic missions. Human spaceflight missions to the Moon and in low Earth orbit have relied upon near-continuous communication with minimal time delays. During these missions, astronauts and mission control communicate interactively to perform tasks and resolve problems in real-time. In contrast, deep-space robotic missions are designed for operations in the presence of significant communication delay - from tens of minutes to hours. Consequently, robotic missions typically employ meticulously scripted and validated command sequences that are intermittently uplinked to the robot for independent execution over long periods. Over the next few years, however, we will see increasing use of robots that blend these two operational approaches. These interactive exploration robots will be remotely operated by humans on Earth or from a spacecraft. These robots will be used to support astronauts on the International Space Station (ISS), to conduct new missions to the Moon, and potentially to enable remote exploration of planetary surfaces in real-time. In this talk, I will discuss the technical challenges associated with building and operating robots in this manner, along with lessons learned from research conducted with the ISS and in the field.

  15. Solar System Exploration Augmented by In-Situ Resource Utilization: Human Mercury and Saturn Exploration

    Science.gov (United States)

    Palaszewski, Bryan

    2015-01-01

    Human and robotic missions to Mercury and Saturn are presented and analyzed. Unique elements of the local planetary environments are discussed and included in the analyses and assessments. Using historical studies of space exploration, in-situ resource utilization (ISRU), and industrialization all point to the vastness of natural resources in the solar system. Advanced propulsion benefitted from these resources in many way. While advanced propulsion systems were proposed in these historical studies, further investigation of nuclear options using high power nuclear thermal and nuclear pulse propulsion as well as advanced chemical propulsion can significantly enhance these scenarios. Updated analyses based on these historical visions will be presented. Nuclear thermal propulsion and ISRU enhanced chemical propulsion landers are assessed for Mercury missions. At Saturn, nuclear pulse propulsion with alternate propellant feed systems and Titan exploration with chemical propulsion options are discussed.

  16. Exploring the existence and potential underpinnings of dog-human and horse-human attachment bonds.

    Science.gov (United States)

    Payne, Elyssa; DeAraugo, Jodi; Bennett, Pauleen; McGreevy, Paul

    2016-04-01

    This article reviews evidence for the existence of attachment bonds directed toward humans in dog-human and horse-human dyads. It explores each species' alignment with the four features of a typical attachment bond: separation-related distress, safe haven, secure base and proximity seeking. While dog-human dyads show evidence of each of these, there is limited alignment for horse-human dyads. These differences are discussed in the light of the different selection paths of domestic dogs and horses as well as the different contexts in which the two species interact with humans. The role of emotional intelligence in humans as a potential mediator for human-animal relationships, attachment or otherwise, is also examined. Finally, future studies, which may clarify the interplay between attachment, human-animal relationships and emotional intelligence, are proposed. Such avenues of research may help us explore the concepts of trust and bonding that are often said to occur at the dog-human and horse-human interface. Copyright © 2015. Published by Elsevier B.V.

  17. Decision Analysis Methods Used to Make Appropriate Investments in Human Exploration Capabilities and Technologies

    Science.gov (United States)

    Williams-Byrd, Julie; Arney, Dale C.; Hay, Jason; Reeves, John D.; Craig, Douglas

    2016-01-01

    NASA is transforming human spaceflight. The Agency is shifting from an exploration-based program with human activities in low Earth orbit (LEO) and targeted robotic missions in deep space to a more sustainable and integrated pioneering approach. Through pioneering, NASA seeks to address national goals to develop the capacity for people to work, learn, operate, live, and thrive safely beyond Earth for extended periods of time. However, pioneering space involves daunting technical challenges of transportation, maintaining health, and enabling crew productivity for long durations in remote, hostile, and alien environments. Prudent investments in capability and technology developments, based on mission need, are critical for enabling a campaign of human exploration missions. There are a wide variety of capabilities and technologies that could enable these missions, so it is a major challenge for NASA's Human Exploration and Operations Mission Directorate (HEOMD) to make knowledgeable portfolio decisions. It is critical for this pioneering initiative that these investment decisions are informed with a prioritization process that is robust and defensible. It is NASA's role to invest in targeted technologies and capabilities that would enable exploration missions even though specific requirements have not been identified. To inform these investments decisions, NASA's HEOMD has supported a variety of analysis activities that prioritize capabilities and technologies. These activities are often based on input from subject matter experts within the NASA community who understand the technical challenges of enabling human exploration missions. This paper will review a variety of processes and methods that NASA has used to prioritize and rank capabilities and technologies applicable to human space exploration. The paper will show the similarities in the various processes and showcase instances were customer specified priorities force modifications to the process. Specifically

  18. Desert RATS 2011: Near-Earth Asteroid Human Exploration Operations

    Science.gov (United States)

    Abercromby, Andrew; Gernhardt, Michael L.; Chappel, Steve

    2012-01-01

    The Desert Research and Technology Studies (D-RATS) 2011 field test involved the planning and execution of a series of exploration scenarios under operational conditions similar to those that would be expected during a human exploration mission to a near-Earth asteroid (NEA). The focus was on understanding the operations tempo during simulated NEA exploration and the implications of communications latency and limited data bandwidth. Anchoring technologies and sampling techniques were not evaluated due to the immaturity of those technologies and the inability to meaningfully test them at D-RATS. Reduced gravity analogs and simulations are being used to fully evaluate Multi-Mission Space Exploration Vehicle (MMSEV) and extravehicular (EVA) operations and interactions in near-weightlessness at a NEA as part of NASA s integrated analogs program. Hypotheses were tested by planning and performing a series of 1-day simulated exploration excursions comparing test conditions all of which involved a single Deep Space Habitat (DSH) and either zero, one, or two MMSEVs; three or four crewmembers; one of two different communications bandwidths; and a 100-second roundtrip communications latency between the field site and Houston. Excursions were executed at the Black Point Lava Flow test site with a Mission Control Center and Science Support Room at Johnson Space Center (JSC) being operated with 100-second roundtrip communication latency to the field. Crews were composed of astronauts and professional field geologists and teams of Mission Operations, Science, and Education & Public Outreach (EPO) experts also supported the mission simulations each day. Data were collected separately from the Crew, Mission Operations, Science, and EPO teams to assess the test conditions from multiple perspectives. For the operations tested, data indicates practically significant benefits may be realized by including at least one MMSEV and by including 4 versus 3 crewmembers in the NEA exploration

  19. Transition in the Human Exploration of Space at NASA

    Science.gov (United States)

    Koch, Carla A.; Cabana, Robert

    2011-01-01

    NASA is taking the next step in human exploration, beyond low Earth orbit. We have been going to low Earth orbit for the past 50 years and are using this experience to work with commercial companies to perform this function. This will free NASA resources to develop the systems necessary to travel to a Near Earth Asteroid, the Moon, Lagrange Points, and eventually Mars. At KSC, we are positioning ourselves to become a multi-user launch complex and everything we are working on is bringing us closer to achieving this goal. A vibrant multi-use spaceport is to the 21st Century what the airport was to the 20th Century - an invaluable transportation hub that supports government needs while promoting economic development and commercial markets beyond Earth's atmosphere. This past year saw the end of Shuttle, but the announcements of NASA's crew module, Orion, and heavy-lift rocket, the SLS, as well as the establishment of the Commercial Crew Program. We have a busy, but very bright future ahead of us and KSC is looking forward to playing an integral part in the next era of human space exploration. The future is SLS, 21st Century Ground Systems Program, and the Commercial Crew Program; and the future is here.

  20. Human Exploration of the Solar System by 2100

    Science.gov (United States)

    Litchford, Ronald J.

    2017-01-01

    It has been suggested that the U.S., in concert with private entities and international partners, set itself on a course to accomplish human exploration of the solar system by the end of this century. This is a strikingly bold vision intended to revitalize the aspirations of HSF in service to the security, economic, and scientific interests of the nation. Solar system distance and time scales impose severe requirements on crewed space transportation systems, however, and fully realizing all objectives in support of this goal will require a multi-decade commitment employing radically advanced technologies - most prominently, space habitats capable of sustaining and protecting life in harsh radiation environments under zero gravity conditions and in-space propulsion technologies capable of rapid deep space transits with earth return, the subject of this paper. While near term mission destinations such as the moon and Mars can be accomplished with chemical propulsion and/or high power SEP, fundamental capability constraints render these traditional systems ineffective for solar system wide exploration. Nuclear based propulsion and alternative energetic methods, on the other hand, represent potential avenues, perhaps the only viable avenues, to high specific power space transport evincing reduced trip time, reduced IMLEO, and expanded deep space reach. Here, very long term HSF objectives for solar system wide exploration are examined in relation to the advanced propulsion technology solution landscape including foundational science, technical/engineering challenges, and developmental prospects.

  1. Panorama 2009 - Exploration-production activities and markets

    International Nuclear Information System (INIS)

    2008-01-01

    After four years of heavy activity, growth on the upstream service and supply markets is slowing. At the end of 2008, the oil and gas price fell subsequent to the decline in demand for petroleum products. This is an indication that exploration-production activity will slow in 2009 and that the price of services - hence sales at service and supply companies - will drop

  2. Solar Power System Evaluated for the Human Exploration of Mars

    Science.gov (United States)

    Kerslake, Thomas W.

    2000-01-01

    The electric power system is a crucial element of any mission for the human exploration of the Martian surface. The bulk of the power generated will be delivered to crew life support systems, extravehicular activity suits, robotic vehicles, and predeployed in situ resource utilization (ISRU) equipment. In one mission scenario, before the crew departs for Mars, the ISRU plant operates for 435 days producing liquefied methane and oxygen for ascent-stage propellants and water for crew life support. About 200 days after ISRU production is completed, the crew arrives for a 500-day surface stay. In this scenario, the power system must operate for a total of 1130 days (equivalent to 1100 Martian "sols"), providing 400 MW-hr of energy to the ISRU plant and up to 18 kW of daytime user power. A photovoltaic power-generation system with regenerative fuel cell (RFC) energy storage has been under study at the NASA Glenn Research Center at Lewis Field. The conceptual power system is dominated by the 4000- m2 class photovoltaic array that is deployed orthogonally as four tent structures, each approximately 5 m on a side and 100-m long. The structures are composed of composite members deployed by an articulating mast, an inflatable boom, or rover vehicles, and are subsequently anchored to the ground. Array panels consist of thin polymer membranes with thin-film solar cells. The array is divided into eight independent electrical sections with solar cell strings operating at 600 V. Energy storage is provided by regenerative fuel cells based on hydrogen-oxygen proton exchange membrane technology. Hydrogen and oxygen reactants are stored in gaseous form at 3000 psi, and the water produced is stored at 14.7 psi. The fuel cell operating temperature is maintained by a 40-m2 deployable pumped-fluid loop radiator that uses water as the working fluid. The power management and distribution (PMAD) architecture features eight independent, regulated 600-Vdc channels. Power management and

  3. Addressing Human System Risks to Future Space Exploration

    Science.gov (United States)

    Paloski, W. H.; Francisco, D. R.; Davis, J. R.

    2015-01-01

    NASA is contemplating future human exploration missions to destinations beyond low Earth orbit, including the Moon, deep-space asteroids, and Mars. While we have learned much about protecting crew health and performance during orbital space flight over the past half-century, the challenges of these future missions far exceed those within our current experience base. To ensure success in these missions, we have developed a Human System Risk Board (HSRB) to identify, quantify, and develop mitigation plans for the extraordinary risks associated with each potential mission scenario. The HSRB comprises research, technology, and operations experts in medicine, physiology, psychology, human factors, radiation, toxicology, microbiology, pharmacology, and food sciences. Methods: Owing to the wide range of potential mission characteristics, we first identified the hazards to human health and performance common to all exploration missions: altered gravity, isolation/confinement, increased radiation, distance from Earth, and hostile/closed environment. Each hazard leads to a set of risks to crew health and/or performance. For example the radiation hazard leads to risks of acute radiation syndrome, central nervous system dysfunction, soft tissue degeneration, and carcinogenesis. Some of these risks (e.g., acute radiation syndrome) could affect crew health or performance during the mission, while others (e.g., carcinogenesis) would more likely affect the crewmember well after the mission ends. We next defined a set of design reference missions (DRM) that would span the range of exploration missions currently under consideration. In addition to standard (6-month) and long-duration (1-year) missions in low Earth orbit (LEO), these DRM include deep space sortie missions of 1 month duration, lunar orbital and landing missions of 1 year duration, deep space journey and asteroid landing missions of 1 year duration, and Mars orbital and landing missions of 3 years duration. We then

  4. ISRU in the Context of Future European Human Mars Exploration

    Science.gov (United States)

    Baker, A. M.; Tomatis, C.

    2002-01-01

    ISRU or In-Situ Resource Utilisation is the use of Martian resources to manufacture, typically, life support consumables (e.g. water, oxygen, breathing buffer gases), and propellant for a return journey to Earth. European studies have shown that some 4kg of reaction mass must be launched to LEO to send 1kg payload to Mars orbit, with landing on the Mars surface reducing payload mass still further. This results in very high transportation costs to Mars, and still higher costs for returning payloads to Earth. There is therefore a major incentive to reduce payload mass for any form of Mars return mission (human or otherwise) by generating consumables on the surface. ESA through its GSTP programme has been investigating the system level design of a number of mission elements as potential European contributions to an international human Mars exploration mission intended for the 2020-2030 timeframe. One of these is an ISRU plant, a small chemical factory to convert feedstock brought from Earth (hydrogen), and Martian atmospheric gases (CO2 and trace quantities of nitrogen and argon) into methane and oxygen propellant for Earth return and life support consumables, in advance of the arrival of astronauts. ISRU technology has been the subject of much investigation around the world, but little detailed research or system level studies have been reported in Europe. Furthermore, the potential applicability of European expertise, technology and sub- system studies to Martian ISRU is not well quantified. Study work covered in this paper has compared existing designs (e.g. NASA's Design Reference Mission, DLR and Mars Society studies) with the latest ESA derived requirements for human Mars exploration, and has generated a system level ISRU design. This paper will review and quantify the baseline chemical reactions essential for ISRU, including CO2 collection and purification, Sabatier reduction of CO2 with hydrogen to methane and water, and electrolysis of water in the context of

  5. Human Exploration Spacecraft Testbed for Integration and Advancement (HESTIA)

    Science.gov (United States)

    Banker, Brian F.; Robinson, Travis

    2016-01-01

    The proposed paper will cover ongoing effort named HESTIA (Human Exploration Spacecraft Testbed for Integration and Advancement), led at the National Aeronautics and Space Administration (NASA) Johnson Space Center (JSC) to promote a cross-subsystem approach to developing Mars-enabling technologies with the ultimate goal of integrated system optimization. HESTIA also aims to develop the infrastructure required to rapidly test these highly integrated systems at a low cost. The initial focus is on the common fluids architecture required to enable human exploration of mars, specifically between life support and in-situ resource utilization (ISRU) subsystems. An overview of the advancements in both integrated technologies, in infrastructure, in simulation, and in modeling capabilities will be presented, as well as the results and findings of integrated testing,. Due to the enormous mass gear-ratio required for human exploration beyond low-earth orbit, (for every 1 kg of payload landed on Mars, 226 kg will be required on Earth), minimization of surface hardware and commodities is paramount. Hardware requirements can be minimized by reduction of equipment performing similar functions though for different subsystems. If hardware could be developed which meets the requirements of both life support and ISRU it could result in the reduction of primary hardware and/or reduction in spares. Minimization of commodities to the surface of mars can be achieved through the creation of higher efficiency systems producing little to no undesired waste, such as a closed-loop life support subsystem. Where complete efficiency is impossible or impractical, makeup commodities could be manufactured via ISRU. Although, utilization of ISRU products (oxygen and water) for crew consumption holds great promise of reducing demands on life support hardware, there exist concerns as to the purity and transportation of commodities. To date, ISRU has been focused on production rates and purities for

  6. Active Learning for Autonomous Intelligent Agents: Exploration, Curiosity, and Interaction

    OpenAIRE

    Lopes, Manuel; Montesano, Luis

    2014-01-01

    In this survey we present different approaches that allow an intelligent agent to explore autonomous its environment to gather information and learn multiple tasks. Different communities proposed different solutions, that are in many cases, similar and/or complementary. These solutions include active learning, exploration/exploitation, online-learning and social learning. The common aspect of all these approaches is that it is the agent to selects and decides what information to gather next. ...

  7. SLS-Derived Lab: Precursor to Deep Space Human Exploration

    Science.gov (United States)

    Griffin, Brand; Lewis, Ruthan; Eppler, Dean; Smitherman, David

    2014-01-01

    Plans to send humans to Mars are in work and the launch system is being built. Are we ready? Robotic missions have successfully demonstrated transportation, entry, landing and surface operations but for human missions there are significant, potentially show-stopping issues. These issues, called Strategic Knowledge Gaps (SKGs) are the unanswered questions concerning long-duration exploration beyond low-earth-orbit. The gaps represent a risk of loss of life or mission and because they require extended exposure to the weightless environment outside earth's protective geo-magnetic field they cannot be resolved on the earth or on the International Space Station (ISS). Placing a laboratory at the relatively close and stable lunar Distant Retrograde Orbit (DRO) provides an accessible location with the requisite environmental conditions for conducting SKG research and testing mitigation solutions. Configurations comprised of multiple 3 meter and 4.3 meter diameter modules have been studied but the most attractive solution uses elements of the human Mars launch vehicle or Space Launch System (SLS) for a Mars proving ground laboratory. A shortened version of an SLS hydrogen propellant tank creates a Skylab-like pressure vessel that flies fully outfitted on a single launch. This not only offers significant savings by incorporating SLS pressure vessel development costs but avoids the expensive ISS approach using many launches with substantial on-orbit assembly before becoming operational. One of the most challenging SKGs is crew radiation protection; this is why SKG laboratory research is combined with Mars transit Habitat systems development. Fundamentally, the two cannot be divorced because using the habitat systems for protection requires actual hardware geometry and material properties intended to contribute to shielding effectiveness. The SKGs are difficult problems, solutions are not obvious, and require integrated, iterative, and multi-disciplinary development. A lunar

  8. The Age of Human-Robot Collaboration: Deep Sea Exploration

    KAUST Repository

    Khatib, Oussama

    2018-01-18

    The promise of oceanic discovery has intrigued scientists and explorers for centuries, whether to study underwater ecology and climate change, or to uncover natural resources and historic secrets buried deep at archaeological sites. Reaching these depth is imperative since factors such as pollution and deep-sea trawling increasingly threaten ecology and archaeological sites. These needs demand a system deploying human-level expertise at the depths, and yet remotely operated vehicles (ROVs) are inadequate for the task. To meet the challenge of dexterous operation at oceanic depths, in collaboration with KAUSTメs Red Sea Research Center and MEKA Robotics, Oussama Khatib and the team developed Ocean One, a bimanual humanoid robot that brings immediate and intuitive haptic interaction to oceanic environments. Introducing Ocean One, the haptic robotic avatar During this lecture, Oussama Khatib will talk about how teaming with the French Ministry of Cultureメs Underwater Archaeology Research Department, they deployed Ocean One in an expedition in the Mediterranean to Louis XIVメs flagship Lune, lying off the coast of Toulon at ninety-one meters. In the spring of 2016, Ocean One became the first robotic avatar to embody a humanメs presence at the seabed. Ocean Oneメs journey in the Mediterranean marks a new level of marine exploration: Much as past technological innovations have impacted society, Ocean Oneメs ability to distance humans physically from dangerous and unreachable work spaces while connecting their skills, intuition, and experience to the task promises to fundamentally alter remote work. Robotic avatars will search for and acquire materials, support equipment, build infrastructure, and perform disaster prevention and recovery operations - be it deep in oceans and mines, at mountain tops, or in space.

  9. Human Outer Solar System Exploration via Q-Thruster Technology

    Science.gov (United States)

    Joosten, B. Kent; White, Harold G.

    2014-01-01

    Propulsion technology development efforts at the NASA Johnson Space Center continue to advance the understanding of the quantum vacuum plasma thruster (QThruster), a form of electric propulsion. Through the use of electric and magnetic fields, a Q-thruster pushes quantum particles (electrons/positrons) in one direction, while the Qthruster recoils to conserve momentum. This principle is similar to how a submarine uses its propeller to push water in one direction, while the submarine recoils to conserve momentum. Based on laboratory results, it appears that continuous specific thrust levels of 0.4 - 4.0 N/kWe are achievable with essentially no onboard propellant consumption. To evaluate the potential of this technology, a mission analysis tool was developed utilizing the Generalized Reduced Gradient non-linear parameter optimization engine contained in the Microsoft Excel® platform. This tool allowed very rapid assessments of "Q-Ship" minimum time transfers from earth to the outer planets and back utilizing parametric variations in thrust acceleration while enforcing constraints on planetary phase angles and minimum heliocentric distances. A conservative Q-Thruster specific thrust assumption (0.4 N/kWe) combined with "moderate" levels of space nuclear power (1 - 2 MWe) and vehicle specific mass (45 - 55 kg/kWe) results in continuous milli-g thrust acceleration, opening up realms of human spaceflight performance completely unattainable by any current systems or near-term proposed technologies. Minimum flight times to Mars are predicted to be as low as 75 days, but perhaps more importantly new "retro-phase" and "gravity-augmented" trajectory shaping techniques were revealed which overcome adverse planetary phasing and allow virtually unrestricted departure and return opportunities. Even more impressively, the Jovian and Saturnian systems would be opened up to human exploration with round-trip times of 21 and 32 months respectively including 6 to 12 months of

  10. A Quantitative ADME-base Tool for Exploring Human ...

    Science.gov (United States)

    Exposure to a wide range of chemicals through our daily habits and routines is ubiquitous and largely unavoidable within modern society. The potential for human exposure, however, has not been quantified for the vast majority of chemicals with wide commercial use. Creative advances in exposure science are needed to support efficient and effective evaluation and management of chemical risks, particularly for chemicals in consumer products. The U.S. Environmental Protection Agency Office of Research and Development is developing, or collaborating in the development of, scientifically-defensible methods for making quantitative or semi-quantitative exposure predictions. The Exposure Prioritization (Ex Priori) model is a simplified, quantitative visual dashboard that provides a rank-ordered internalized dose metric to simultaneously explore exposures across chemical space (not chemical by chemical). Diverse data streams are integrated within the interface such that different exposure scenarios for “individual,” “population,” or “professional” time-use profiles can be interchanged to tailor exposure and quantitatively explore multi-chemical signatures of exposure, internalized dose (uptake), body burden, and elimination. Ex Priori has been designed as an adaptable systems framework that synthesizes knowledge from various domains and is amenable to new knowledge/information. As such, it algorithmically captures the totality of exposure across pathways. It

  11. Human Space Exploration: The Moon, Mars, and Beyond

    Science.gov (United States)

    Sexton, Jeffrey D.

    2007-01-01

    America is returning to the Moon in preparation for the first human footprint on Mars, guided by the U.S. Vision for Space Exploration. This presentation will discuss NASA's mission, the reasons for returning to the Moon and going to Mars, and how NASA will accomplish that mission in ways that promote leadership in space and economic expansion on the new frontier. The primary goals of the Vision for Space Exploration are to finish the International Space Station, retire the Space Shuttle, and build the new spacecraft needed, to return people to the Moon and go to Mars. The Vision commits NASA and the nation to an agenda of exploration that also includes robotic exploration and technology development, while building on lessons learned over 50 years of hard-won experience. Why the Moon? Many questions about the Moon's potential resources and how its history is linked to that of Earth were spurred by the brief Apollo explorations of the 1960s and 1970s. This new venture will carry more explorers to more diverse landing sites with more capable tools and equipment for extended expeditions. The Moon also will serve as a training ground before embarking on the longer, more difficult trip to Mars. NASA plans to build a lunar outpost at one of the lunar poles, learn to live off the land, and reduce dePendence on Earth for longer missions. America needs to extend its ability to survive in hostile environments close to our home planet before astronauts will reach Mars, a planet very much like Earth. NASA has worked with scientists to define lunar exploration goals and is addressing the opportunities for a range of scientific study on Mars. In order to reach the Moon and Mars within a lifetime and within budget, NASA is building on common hardware, shared knowledge, and unique experience derived from the Apollo Saturn, Space Shuttle and contemporary commercial launch vehicle programs. The journeys to the Moon and Mars will require a variety of vehicles, including the Ares I

  12. A LARGE HUMAN CENTRIFUGE FOR EXPLORATION AND EXPLOITATION RESEARCH

    Directory of Open Access Journals (Sweden)

    Jack J.W.A. van Loon

    2012-06-01

    Full Text Available This paper addresses concepts regarding the development of an Altered Gravity Platform (AGP that will serve as a research platform for human space exploration. Space flight causes a multitude of physiological problems, many of which are due to gravity level transitions. Going from Earth's gravity to microgravity generates fluid shifts, space motion sickness, cardiovascular deconditioning among other changes, and returning to a gravity environment again puts the astronauts under similar stressors. A prolonged stay in microgravity provokes additional deleterious changes such as bone loss, muscle atrophy and loss of coordination or specific psychological stresses. To prepare for future manned space exploration missions, a ground-based research test bed for validating countermeasures against the deleterious effects of g-level transitions is needed. The proposed AGP is a large rotating facility (diameter > 150 m, where gravity levels ranging from 1.1 to 1.5g are generated, covering short episodes or during prolonged stays of weeks or even months. On this platform, facilities are built where a crew of 6 to 8 humans can live autonomously. Adaptation from 1 g to higher g levels can be studied extensively and monitored continuously. Similarly, re-adaptation back to 1 g, after a prolonged period of altered g can also be investigated. Study of the physiological and psychological adaptation to changing g-levels will provide instrumental and predictive knowledge to better define the ultimate countermeasures that are needed for future successful manned space exploration missions to the Moon, Mars and elsewhere. The AGP initiative will allow scientific top experts in Europe and worldwide to investigate the necessary scientific, operational, and engineering inputs required for such space missions. Because so many different physiological systems are involved in adaptation to gravity levels, a multidisciplinary approach is crucial. One of the final and crucial

  13. The role of human resource management in open innovation: exploring the relation between HR practices and OI

    OpenAIRE

    Paul, Svenja

    2013-01-01

    How do human resource practices strengthen open innovation activities? This inductive study of six cases led to propositions exploring that question. I thereby investigated the role of human resource management in open innovation, specifically the relation between HR practices and an employee's willingness to embrace open innovation.

  14. Exploring Urban Taxi Drivers’ Activity Distribution Based on GPS Data

    Directory of Open Access Journals (Sweden)

    Xiaowei Hu

    2014-01-01

    Full Text Available With the rapid development of information communication technology and data mining technology, we can obtain taxi vehicle’s real time operation status through the large-scale taxi GPS trajectories data and explore the drivers’ activity distribution characteristics. Based on the 204 continuous hours of 3198 taxi vehicles’ operation data of Shenzhen, China, this paper analyzed the urban taxi driver’s activity distribution characteristics from different temporal and spatial levels. In the time level, we identified the difference with taxi daily operation pattern (weekday versus weekends, continuous time in one day, passengers in vehicle time, and taxi drivers’ operation frequency; in the space level, we explored the taxi driver’s searching pattern, including searching activity space distribution and the relationship between the pick-up locations and the drop-off locations. This research can be helpful for urban taxi drivers’ operation and behavior pattern identification, as well as the contribution to the geographical activity space analysis.

  15. Space Resource Utilization: Near-Term Missions and Long-Term Plans for Human Exploration

    Science.gov (United States)

    Sanders, Gerald B.

    2015-01-01

    A primary goal of all major space faring nations is to explore space: from the Earth with telescopes, with robotic probes and space telescopes, and with humans. For the US National Aeronautics and Space Administration (NASA), this pursuit is captured in three important strategic goals: 1. Ascertain the content, origin, and evolution of the solar system and the potential for life elsewhere, 2. Extend and sustain human activities across the solar system (especially the surface of Mars), and 3. Create innovative new space technologies for exploration, science, and economic future. While specific missions and destinations are still being discussed as to what comes first, it is imperative for NASA that it foster the development and implementation of new technologies and approaches that make space exploration affordable and sustainable. Critical to achieving affordable and sustainable human exploration beyond low Earth orbit (LEO) is the development of technologies and systems to identify, extract, and use resources in space instead of bringing everything from Earth. To reduce the development and implementation costs for space resource utilization, often called In Situ Resource Utilization (ISRU), it is imperative to work with terrestrial mining companies to spin-in/spin-off technologies and capabilities, and space mining companies to expand our economy beyond Earth orbit. In the last two years, NASA has focused on developing and implementing a sustainable human space exploration program with the ultimate goal of exploring the surface of Mars with humans. The plan involves developing technology and capability building blocks critical for sustained exploration starting with the Space Launch System (SLS) and Orion crew spacecraft and utilizing the International Space Station as a springboard into the solar system. The evolvable plan develops and expands human exploration in phases starting with missions that are reliant on Earth, to performing ever more challenging and

  16. Exploration and production activities and market - Panorama 2008

    International Nuclear Information System (INIS)

    2007-01-01

    Following two banner years for the oil service and supply sector, marked by strong activity and a substantial increase in prices, the Exploration and Production market continued at a frenetic pace in 2007, although certain local markets retreated. In 2008, activity should stay high and prices should start stabilizing. With services in short supply, companies in the sector have been able to shift the balance of power with oil firms in their favor

  17. Exploring the Use of Technology for Active Aging and Thriving.

    Science.gov (United States)

    Øderud, Tone; Østensen, Elisabeth; Gjevjon, Edith Roth; Moen, Anne

    2017-01-01

    The study explores how older adults with limited digital experience become users of tablet computers (iPad) with Internet access, and how the tablet computers become part of their daily life facilitating active aging and thriving. Volunteer adolescents were mobilised to teach and follow up the participants regularly.

  18. Exploring the Greenhouse Effect through Physics-Oriented Activities

    Science.gov (United States)

    Browne, Kerry P.; Laws, Priscilla W.

    2003-01-01

    We are developing a new activity-based unit on global warming and the environment as part of the "Explorations in Physics Curriculum." We describe the current status of this unit, which focuses on helping students understand the greenhouse effect and its relationship to global warming. We outline several problems encountered in testing the unit…

  19. SLS-Derived Lab- Precursor to Deep Space Human Exploration

    Science.gov (United States)

    Griffin, Brand M.; Lewis, Ruthan; Eppler, Dean; Smitherman, David

    2015-01-01

    Plans to send humans to Mars are in the works and the launch system is being built. Are we ready? Transportation, entry, landing, and surface operations have been successfully demonstrated for robotic missions. However, for human missions, there are significant, potentially show-stopping issues. These issues, called Strategic Knowledge Gaps (SKGs), are the unanswered questions concerning long duration exploration Beyond low Earth Orbit (BEO). The gaps represent a risk of loss of life or mission and because they require extended exposure to the weightless environment outside of earth's protective geo-magnetic field, they cannot be resolved on Earth or on the International Space Station (ISS). Placing a laboratory at a relatively close and stable lunar Distant Retrograde Orbit (DRO) provides an accessible location with the requisite environmental conditions for conducting SKG research and testing mitigation solutions. Configurations comprised of multiple 3 m and 4.3 m diameter modules have been studied but the most attractive solution uses elements of the human Mars launch vehicle or Space Launch System (SLS) for a Mars proving ground laboratory. A shortened version of an SLS hydrogen propellant tank creates a Skylab-like pressure vessel that flies fully outfitted on a single launch. This not only offers significant savings by incorporating SLS pressure vessel development costs but avoids the expensive ISS approach using many launches with substantial on-orbit assembly before becoming operational. One of the most challenging SKGs is crew radiation protection; this is why SKG laboratory research is combined with Mars transit habitat systems development. Fundamentally, the two cannot be divorced because using the habitat systems for protection requires actual hardware geometry and material properties intended to contribute to shielding effectiveness. The SKGs are difficult problems. The solutions to these problems are not obvious; they require integrated, iterative

  20. Human activities threaten coral reefs

    International Nuclear Information System (INIS)

    Tveitdal, Svein; Bjoerke, Aake

    2002-01-01

    Research indicates that 58 per cent of the coral reefs of the world are threatened by human activities. Pollution and global heating represent some of the threats. Coral reefs just beneath the surface of the sea are very sensitive to temperature changes. Since 1979, mass death of coral reefs has been reported increasingly often. More than 1000 marine species live in the coral reefs, among these are one fourth of all marine species of fish. It is imperative that the coral reefs be preserved, as coastal communities all over the world depend on them as sources of food and as they are the raw materials for important medicines. The article discusses the threats to the coral reefs in general and does not single out any particular energy-related activity as the principal threat. For instance, the El-Nino phenomenon of the Pacific Ocean is probably involved in mass death of coral reefs and in the North Sea large parts of deep-water reefs have been crushed by heavy beam trawlers fishing for bottom fish

  1. Human Health and Performance Considerations for Exploration of Near-Earth Asteroids

    Science.gov (United States)

    Kundrot, Craig; Steinberg, Susan; Charles, John

    2010-01-01

    This presentation will describe the human health and performance issues that are anticipated for the human exploration of near-Earth asteroids (NEA). Humans are considered a system in the design of any such deep-space exploration mission, and exploration of NEA presents unique challenges for the human system. Key factors that define the mission are those that are strongly affected by distance and duration. The most critical of these is deep-space radiation exposure without even the temporary shielding of a nearby large planetary body. The current space radiation permissible exposure limits (PEL) restrict mission duration to 3-10 months depending on age and gender of crewmembers and stage of the solar cycle. Factors that affect mission architecture include medical capability; countermeasures for bone, muscle, and cardiovascular atrophy during continuous weightlessness; restricted food supplies; and limited habitable volume. The design of a habitat that can maintain the physical and psychological health of the crew and support mission operations with limited intervention from Earth will require an integrated research and development effort by NASA s Human Research Program, engineering, and human factors groups. Limited abort and return options for an NEA mission are anticipated to have important effects on crew psychology as well as influence medical supplies and training requirements of the crew. Other important factors are those related to isolation, confinement, communication delays, autonomous operations, task design, small crew size, and even the unchanging view outside the windows for most of the mission. Geological properties of the NEA will influence design of sample handling and containment, and extravehicular activity capabilities including suit ports and tools. A robotic precursor mission that collects basic information on NEA surface properties would reduce uncertainty about these aspects of the mission as well as aid in design of mission architecture and

  2. Human Space Exploration and Human Space Flight: Latency and the Cognitive Scale of the Universe

    Science.gov (United States)

    Lester, Dan; Thronson, Harley

    2011-01-01

    The role of telerobotics in space exploration as placing human cognition on other worlds is limited almost entirely by the speed of light, and the consequent communications latency that results from large distances. This latency is the time delay between the human brain at one end, and the telerobotic effector and sensor at the other end. While telerobotics and virtual presence is a technology that is rapidly becoming more sophisticated, with strong commercial interest on the Earth, this time delay, along with the neurological timescale of a human being, quantitatively defines the cognitive horizon for any locale in space. That is, how distant can an operator be from a robot and not be significantly impacted by latency? We explore that cognitive timescale of the universe, and consider the implications for telerobotics, human space flight, and participation by larger numbers of people in space exploration. We conclude that, with advanced telepresence, sophisticated robots could be operated with high cognition throughout a lunar hemisphere by astronauts within a station at an Earth-Moon Ll or L2 venue. Likewise, complex telerobotic servicing of satellites in geosynchronous orbit can be carried out from suitable terrestrial stations.

  3. Visual exploration and analysis of human-robot interaction rules

    Science.gov (United States)

    Zhang, Hui; Boyles, Michael J.

    2013-01-01

    We present a novel interaction paradigm for the visual exploration, manipulation and analysis of human-robot interaction (HRI) rules; our development is implemented using a visual programming interface and exploits key techniques drawn from both information visualization and visual data mining to facilitate the interaction design and knowledge discovery process. HRI is often concerned with manipulations of multi-modal signals, events, and commands that form various kinds of interaction rules. Depicting, manipulating and sharing such design-level information is a compelling challenge. Furthermore, the closed loop between HRI programming and knowledge discovery from empirical data is a relatively long cycle. This, in turn, makes design-level verification nearly impossible to perform in an earlier phase. In our work, we exploit a drag-and-drop user interface and visual languages to support depicting responsive behaviors from social participants when they interact with their partners. For our principal test case of gaze-contingent HRI interfaces, this permits us to program and debug the robots' responsive behaviors through a graphical data-flow chart editor. We exploit additional program manipulation interfaces to provide still further improvement to our programming experience: by simulating the interaction dynamics between a human and a robot behavior model, we allow the researchers to generate, trace and study the perception-action dynamics with a social interaction simulation to verify and refine their designs. Finally, we extend our visual manipulation environment with a visual data-mining tool that allows the user to investigate interesting phenomena such as joint attention and sequential behavioral patterns from multiple multi-modal data streams. We have created instances of HRI interfaces to evaluate and refine our development paradigm. As far as we are aware, this paper reports the first program manipulation paradigm that integrates visual programming

  4. Uranium exploration in Egypt past, current and future activities

    International Nuclear Information System (INIS)

    Farag, N.

    2014-01-01

    The Egyptian Nuclear Materials Authority (NMA), is the government body responsible for exploration of the nuclear raw materials in the country. The early NMA U-exploration activities has included training of exploration teams, conduction of airborne, ground follow up and preliminary geological mapping as well as execution of limited exploration drilling. A number of TC projects and expert missions were mainly executed in collaboration with the IAEA for this purpose. These efforts have resulted in the discovery of seven U-potential prospects. NMA has also exercised limited heap leaching on experimental scale and obtained small amounts of U-concentrates, utilized for R & D purposes. However, the exploration activities remained in the preliminary phases and did not succeed to reach either reliable evaluation of the discovered uranium resources or running productive U-exploitation. By the end of the last decade, Egypt has declared the intention to adopt a peaceful program for electric power generation; this implied NMA to implement a twofold plan as described hereafter. Regarding the conventional U-resources, occurring in the Eastern Desert, NMA focus the exploration activities on the younger granites of Pan African type, and the associated inter-mountain basins. The activities will be restricted to the evaluation of U-reserves in at least three of the most promising uranium prospects that still require extensive exploration drilling programs. NMA is now implementing an international bid announcement seeking for partnership of an experienced international firm, to assess the uranium resources in these sites, in addition to receiving relevant IAEA/TC programs. Regarding non-conventional resources, the black sand project is mainly a resource of a titanium and zirconium minerals; however, NMA is now trying to process monazite to obtain mainly Th and minor U by-products. NMA has successfully completed an exploration study and. the Government of Egypt has recently

  5. Lunar Polar In Situ Resource Utilization (ISRU) as a Stepping Stone for Human Exploration

    Science.gov (United States)

    Sanders, Gerald B.

    2013-01-01

    A major emphasis of NASA is to extend and expand human exploration across the solar system. While specific destinations are still being discussed as to what comes first, it is imperative that NASA create new technologies and approaches that make space exploration affordable and sustainable. Critical to achieving affordable and sustainable exploration beyond low Earth orbit (LEO) are the development of technologies and approaches for advanced robotics, power, propulsion, habitats, life support, and especially, space resource utilization systems. Space resources and how to use them, often called In-Situ Resource Utilization (ISRU), can have a tremendous beneficial impact on robotic and human exploration of the Moon, Mars, Phobos, and Near Earth Objects (NEOs), while at the same time helping to solve terrestrial challenges and enabling commercial space activities. The search for lunar resources, demonstration of extraterrestrial mining, and the utilization of resource-derived products, especially from polar volatiles, can be a stepping stone for subsequent human exploration missions to other destinations of interest due to the proximity of the Moon, complimentary environments and resources, and the demonstration of critical technologies, processes, and operations. ISRU and the Moon: There are four main areas of development interest with respect to finding, obtaining, extracting, and using space resources: Prospecting for resources, Production of mission critical consumables like propellants and life support gases, Civil engineering and construction, and Energy production, storage, and transfer. The search for potential resources and the production of mission critical consumables are the primary focus of current NASA technology and system development activities since they provide the greatest initial reduction in mission mass, cost, and risk. Because of the proximity of the Moon, understanding lunar resources and developing, demonstrating, and implementing lunar ISRU

  6. A Review of Human Activity Recognition Methods

    Directory of Open Access Journals (Sweden)

    Michalis eVrigkas

    2015-11-01

    Full Text Available Recognizing human activities from video sequences or still images is a challenging task due to problems such as background clutter, partial occlusion, changes in scale, viewpoint, lighting, and appearance. Many applications, including video surveillance systems, human-computer interaction, and robotics for human behavior characterization, require a multiple activity recognition system. In this work, we provide a detailed review of recent and state-of-the-art research advances in the field of human activity classification. We propose a categorization of human activity methodologies and discuss their advantages and limitations. In particular, we divide human activity classification methods into two large categories according to whether they use data from different modalities or not. Then, each of these categories is further analyzed into sub-categories, which reflect how they model human activities and what type of activities they are interested in. Moreover, we provide a comprehensive analysis of the existing, publicly available human activity classification datasets and examine the requirements for an ideal human activity recognition dataset. Finally, we report the characteristics of future research directions and present some open issues on human activity recognition.

  7. A mars communication constellation for human exploration and network science

    Science.gov (United States)

    Castellini, Francesco; Simonetto, Andrea; Martini, Roberto; Lavagna, Michèle

    2010-01-01

    This paper analyses the possibility of exploiting a small spacecrafts constellation around Mars to ensure a complete and continuous coverage of the planet, for the purpose of supporting future human and robotic operations and taking advantage of optical transmission techniques. The study foresees such a communications mission to be implemented at least after 2020 and a high data-rate requirement is imposed for the return of huge scientific data from massive robotic exploration or to allow video transmissions from a possible human outpost. In addition, the set-up of a communication constellation around Mars would give the opportunity of exploiting this multi-platform infrastructure to perform network science, that would largely increase our knowledge of the planet. The paper covers all technical aspects of a feasibility study performed for the primary communications mission. Results are presented for the system trade-offs, including communication architecture, constellation configuration and transfer strategy, and the mission analysis optimization, performed through the application of a multi-objective genetic algorithm to two models of increasing difficulty for the low-thrust trajectory definition. The resulting communication architecture is quite complex and includes six 530 kg spacecrafts on two different orbital planes, plus one redundant unit per plane, that ensure complete coverage of the planet’s surface; communications between the satellites and Earth are achieved through optical links, that allow lower mass and power consumption with respect to traditional radio-frequency technology, while inter-satellite links and spacecrafts-to-Mars connections are ensured by radio transmissions. The resulting data-rates for Earth-Mars uplink and downlink, satellite-to-satellite and satellite-to-surface are respectively 13.7 Mbps, 10.2 Mbps, 4.8 Mbps and 4.3 Mbps, in worst-case. Two electric propulsion modules are foreseen, to be placed on a C3˜0 escape orbit with two

  8. Low-Latency Teleoperations for Human Exploration and Evolvable Mars Campaign

    Science.gov (United States)

    Lupisella, Mark; Wright, Michael; Arney, Dale; Gershman, Bob; Stillwagen, Fred; Bobskill, Marianne; Johnson, James; Shyface, Hilary; Larman, Kevin; Lewis, Ruthan; hide

    2015-01-01

    NASA has been analyzing a number of mission concepts and activities that involve low-latency telerobotic (LLT) operations. One mission concept that will be covered in this presentation is Crew-Assisted Sample Return which involves the crew acquiring samples (1) that have already been delivered to space, and or acquiring samples via LLT from orbit to a planetary surface and then launching the samples to space to be captured in space and then returned to the earth with the crew. Both versions of have key roles for low-latency teleoperations. More broadly, the NASA Evolvable Mars Campaign is exploring a number of other activities that involve LLT, such as: (a) human asteroid missions, (b) PhobosDeimos missions, (c) Mars human landing site reconnaissance and site preparation, and (d) Mars sample handling and analysis. Many of these activities could be conducted from Mars orbit and also with the crew on the Mars surface remotely operating assets elsewhere on the surface, e.g. for exploring Mars special regions and or teleoperating a sample analysis laboratory both of which may help address planetary protection concerns. The operational and technology implications of low-latency teleoperations will be explored, including discussion of relevant items in the NASA Technology Roadmap and also how previously deployed robotic assets from any source could subsequently be used by astronauts via LLT.

  9. Activation of human herpesvirus replication by apoptosis.

    Science.gov (United States)

    Prasad, Alka; Remick, Jill; Zeichner, Steven L

    2013-10-01

    A central feature of herpesvirus biology is the ability of herpesviruses to remain latent within host cells. Classically, exposure to inducing agents, like activating cytokines or phorbol esters that stimulate host cell signal transduction events, and epigenetic agents (e.g., butyrate) was thought to end latency. We recently showed that Kaposi's sarcoma-associated herpesvirus (KSHV, or human herpesvirus-8 [HHV-8]) has another, alternative emergency escape replication pathway that is triggered when KSHV's host cell undergoes apoptosis, characterized by the lack of a requirement for the replication and transcription activator (RTA) protein, accelerated late gene kinetics, and production of virus with decreased infectivity. Caspase-3 is necessary and sufficient to initiate the alternative replication program. HSV-1 was also recently shown to initiate replication in response to host cell apoptosis. These observations suggested that an alternative apoptosis-triggered replication program might be a general feature of herpesvirus biology and that apoptosis-initiated herpesvirus replication may have clinical implications, particularly for herpesviruses that almost universally infect humans. To explore whether an alternative apoptosis-initiated replication program is a common feature of herpesvirus biology, we studied cell lines latently infected with Epstein-Barr virus/HHV-4, HHV-6A, HHV-6B, HHV-7, and KSHV. We found that apoptosis triggers replication for each HHV studied, with caspase-3 being necessary and sufficient for HHV replication. An alternative apoptosis-initiated replication program appears to be a common feature of HHV biology. We also found that commonly used cytotoxic chemotherapeutic agents activate HHV replication, which suggests that treatments that promote apoptosis may lead to activation of latent herpesviruses, with potential clinical significance.

  10. Brain Activation During Singing: "Clef de Sol Activation" Is the "Concert" of the Human Brain.

    Science.gov (United States)

    Mavridis, Ioannis N; Pyrgelis, Efstratios-Stylianos

    2016-03-01

    Humans are the most complex singers in nature, and the human voice is thought by many to be the most beautiful musical instrument. Aside from spoken language, singing represents a second mode of acoustic communication in humans. The purpose of this review article is to explore the functional anatomy of the "singing" brain. Methodologically, the existing literature regarding activation of the human brain during singing was carefully reviewed, with emphasis on the anatomic localization of such activation. Relevant human studies are mainly neuroimaging studies, namely functional magnetic resonance imaging and positron emission tomography studies. Singing necessitates activation of several cortical, subcortical, cerebellar, and brainstem areas, served and coordinated by multiple neural networks. Functionally vital cortical areas of the frontal, parietal, and temporal lobes bilaterally participate in the brain's activation process during singing, confirming the latter's role in human communication. Perisylvian cortical activity of the right hemisphere seems to be the most crucial component of this activation. This also explains why aphasic patients due to left hemispheric lesions are able to sing but not speak the same words. The term clef de sol activation is proposed for this crucial perisylvian cortical activation due to the clef de sol shape of the topographical distribution of these cortical areas around the sylvian fissure. Further research is needed to explore the connectivity and sequence of how the human brain activates to sing.

  11. Bidirectional Active Learning: A Two-Way Exploration Into Unlabeled and Labeled Data Set.

    Science.gov (United States)

    Zhang, Xiao-Yu; Wang, Shupeng; Yun, Xiaochun

    2015-12-01

    In practical machine learning applications, human instruction is indispensable for model construction. To utilize the precious labeling effort effectively, active learning queries the user with selective sampling in an interactive way. Traditional active learning techniques merely focus on the unlabeled data set under a unidirectional exploration framework and suffer from model deterioration in the presence of noise. To address this problem, this paper proposes a novel bidirectional active learning algorithm that explores into both unlabeled and labeled data sets simultaneously in a two-way process. For the acquisition of new knowledge, forward learning queries the most informative instances from unlabeled data set. For the introspection of learned knowledge, backward learning detects the most suspiciously unreliable instances within the labeled data set. Under the two-way exploration framework, the generalization ability of the learning model can be greatly improved, which is demonstrated by the encouraging experimental results.

  12. Oil price sinks drilling : exploration activity drops during third quarter

    International Nuclear Information System (INIS)

    Harrington, P.

    1998-01-01

    The decline in oil and gas exploration activity in Western Canada is discussed. In the third quarter of 1998, a total of 397 exploratory tests were reported compared to 768 during the same period in 1997. Low world oil prices are blamed as the cause of this decline. The declining exploration activity in 1998 was led by Alberta, with 289 new pool wildcat (NPW) announcements along with 25 new field wildcat (NFW) locations. Saskatchewan was in second place with 67 exploratory announcements, but compared to 329 in 1997, this represents an 80 per cent drop. British Columbia had a total of 15 exploratory wells resulting in three oil discoveries and 11 gas completions. Geological features, well characteristics and early production figures from several of the new wells in the Killam fields in southwest Saskatchewan were received special attention. 1 tab., 3 figs

  13. Impacts of Launch Vehicle Fairing Size on Human Exploration Architectures

    Science.gov (United States)

    Jefferies, Sharon; Collins, Tim; Dwyer Cianciolo, Alicia; Polsgrove, Tara

    2017-01-01

    presents the results of the analyses performed, the potential changes to mission architectures and campaigns that result, and the general trends that are more broadly applicable to any element design or mission planning for human exploration.

  14. Human Exploration using Real-Time Robotic Operations (HERRO): A space exploration strategy for the 21st century

    Science.gov (United States)

    Schmidt, George R.; Landis, Geoffrey A.; Oleson, Steven R.

    2012-11-01

    This paper presents an exploration strategy for human missions beyond Low Earth Orbit (LEO) and the Moon that combines the best features of human and robotic spaceflight. This "Human Exploration using Real-time Robotic Operations" (HERRO) strategy refrains from placing humans on the surfaces of the Moon and Mars in the near-term. Rather, it focuses on sending piloted spacecraft and crews into orbit around Mars and other exploration targets of interest, and conducting astronaut exploration of the surfaces using telerobots and remotely-controlled systems. By eliminating the significant communications delay or "latency" with Earth due to the speed of light limit, teleoperation provides scientists real-time control of rovers and other sophisticated instruments. This in effect gives them a "virtual presence" on planetary surfaces, and thus expands the scientific return at these destinations. HERRO mitigates several of the major issues that have hindered the progress of human spaceflight beyond Low Earth Orbit (LEO) by: (1) broadening the range of destinations for near-term human missions; (2) reducing cost and risk through less complexity and fewer man-rated elements; (3) offering benefits of human-equivalent in-situ cognition, decision-making and field-work on planetary bodies; (4) providing a simpler approach to returning samples from Mars and planetary surfaces; and (5) facilitating opportunities for international collaboration through contribution of diverse robotic systems. HERRO provides a firm justification for human spaceflight—one that expands the near-term capabilities of scientific exploration while providing the space transportation infrastructure needed for eventual human landings in the future.

  15. Panorama 2010: Activities and markets in exploration-production

    International Nuclear Information System (INIS)

    Saniere, A.; Serbutoviez, S.

    2010-01-01

    At year-end 2008, a sharp decrease in oil and gas demand coupled with a credit crunch caused the postponement of many exploration-production projects. 2009 was marked by substantial over-capacity in terms of equipment and installations, which drove down the level of activity, the price of services and the income of suppliers. The year is nonetheless perceived as marking a lull in an upward cycle and capital expenditure is expected to rise slightly in 2010. (author)

  16. Panorama 2011: Exploration-production: activities and markets

    International Nuclear Information System (INIS)

    Saniere, A.; Serbutoviez, S.

    2011-01-01

    After a year of economic crisis in 2009, oil companies saw renewed demand and are reporting increased investment in 2010. Exploration-production activity is resuming, at a pace that varies by sector, but prices for goods and services remain depressed as a result of existing over-capacity. In particular, developments in Brazil and Iraq and growth in unconventional gas are helping to maintain the level of activity. Meanwhile, the catastrophic oil spill in the Gulf of Mexico is leading to tighter regulations and safety standards in offshore drilling. (author)

  17. Advanced Technologies for Robotic Exploration Leading to Human Exploration: Results from the SpaceOps 2015 Workshop

    Science.gov (United States)

    Lupisella, Mark L.; Mueller, Thomas

    2016-01-01

    This paper will provide a summary and analysis of the SpaceOps 2015 Workshop all-day session on "Advanced Technologies for Robotic Exploration, Leading to Human Exploration", held at Fucino Space Center, Italy on June 12th, 2015. The session was primarily intended to explore how robotic missions and robotics technologies more generally can help lead to human exploration missions. The session included a wide range of presentations that were roughly grouped into (1) broader background, conceptual, and high-level operations concepts presentations such as the International Space Exploration Coordination Group Roadmap, followed by (2) more detailed narrower presentations such as rover autonomy and communications. The broader presentations helped to provide context and specific technical hooks, and helped lay a foundation for the narrower presentations on more specific challenges and technologies, as well as for the discussion that followed. The discussion that followed the presentations touched on key questions, themes, actions and potential international collaboration opportunities. Some of the themes that were touched on were (1) multi-agent systems, (2) decentralized command and control, (3) autonomy, (4) low-latency teleoperations, (5) science operations, (6) communications, (7) technology pull vs. technology push, and (8) the roles and challenges of operations in early human architecture and mission concept formulation. A number of potential action items resulted from the workshop session, including: (1) using CCSDS as a further collaboration mechanism for human mission operations, (2) making further contact with subject matter experts, (3) initiating informal collaborative efforts to allow for rapid and efficient implementation, and (4) exploring how SpaceOps can support collaboration and information exchange with human exploration efforts. This paper will summarize the session and provide an overview of the above subjects as they emerged from the SpaceOps 2015

  18. Evaluating Space Weather Architecture Options to Support Human Deep Space Exploration of the Moon and Mars

    Science.gov (United States)

    Parker, L.; Minow, J.; Pulkkinen, A.; Fry, D.; Semones, E.; Allen, J.; St Cyr, C.; Mertens, C.; Jun, I.; Onsager, T.; Hock, R.

    2018-02-01

    NASA's Engineering and Space Center (NESC) is conducting an independent technical assessment of space environment monitoring and forecasting architecture options to support human and robotic deep space exploration.

  19. Active explorers show low learning performance in a social insect

    Institute of Scientific and Technical Information of China (English)

    Eve UDINO; Margot PEREZ; Claudio CARERE; Patrizia d'ETTORRE

    2017-01-01

    An intriguing question in behavioral biology is whether consistent individual differences (called animal personalities) relate to variation in cognitive performance because commonly measured personality traits may be associated with risk-reward trade-offs.Social insects,whose learning abilities have been extensively characterized,show consistent behavioral variability,both at colony and at individual level.We investigated the possible link between personality traits and learning performance in the carpenter ant Camponotus aethiops.Exploratory activity,sociability,and aggression were assessed twice in ant foragers.Behaviors differed among individuals,they were partly repeatable across time and exploratory activity correlated positively with aggression.Learning abilities were quantified by differential conditioning of the maxilla-labium extension response,a task that requires cue perception and information storage.We found that exploratory activity of individual ants significantly predicted learning performance:"active-explorers" were slower in learning the task than "inactive-explorers".The results suggest for the first time a link between a personality trait and cognitive performance in eusocial insects,and that the underlying individual variability could affect colony performance and success.

  20. Potential Applications for Radioisotope Power Systems in Support of Human Exploration Missions

    Science.gov (United States)

    Cataldo, Robert L.; Colozza, Anthony J.; Schmitz, Paul C.

    2013-01-01

    Radioisotope power systems (RPS) for space applications have powered over 27 U.S. space systems, starting with Transit 4A and 4B in 1961, and more recently with the successful landing of the Mars Science Laboratory rover Curiosity in August 2012. RPS enable missions with destinations far from the Sun with faint solar flux, on planetary surfaces with dense or dusty atmospheres, and at places with long eclipse periods where solar array sizes and energy storage mass become impractical. RPS could also provide an enabling capability in support of human exploration activities. It is envisioned that with the higher power needs of most human mission concepts, a high efficiency thermal-to-electric technology would be required such as the Advanced Stirling Radioisotope generator (ASRG). The ASRG should be capable of a four-fold improvement in efficiency over traditional thermoelectric RPS. While it may be impractical to use RPS as a main power source, many other applications could be considered, such as crewed pressurized rovers, in-situ resource production of propellants, back-up habitat power, drilling, any mobile or remote activity from the main base habitat, etc. This paper will identify potential applications and provide concepts that could be a practical extension of the current ASRG design in providing for robust and flexible use of RPS on human exploration missions.

  1. Self-organization via active exploration in robotic applications

    Science.gov (United States)

    Ogmen, H.; Prakash, R. V.

    1992-01-01

    We describe a neural network based robotic system. Unlike traditional robotic systems, our approach focussed on non-stationary problems. We indicate that self-organization capability is necessary for any system to operate successfully in a non-stationary environment. We suggest that self-organization should be based on an active exploration process. We investigated neural architectures having novelty sensitivity, selective attention, reinforcement learning, habit formation, flexible criteria categorization properties and analyzed the resulting behavior (consisting of an intelligent initiation of exploration) by computer simulations. While various computer vision researchers acknowledged recently the importance of active processes (Swain and Stricker, 1991), the proposed approaches within the new framework still suffer from a lack of self-organization (Aloimonos and Bandyopadhyay, 1987; Bajcsy, 1988). A self-organizing, neural network based robot (MAVIN) has been recently proposed (Baloch and Waxman, 1991). This robot has the capability of position, size rotation invariant pattern categorization, recognition and pavlovian conditioning. Our robot does not have initially invariant processing properties. The reason for this is the emphasis we put on active exploration. We maintain the point of view that such invariant properties emerge from an internalization of exploratory sensory-motor activity. Rather than coding the equilibria of such mental capabilities, we are seeking to capture its dynamics to understand on the one hand how the emergence of such invariances is possible and on the other hand the dynamics that lead to these invariances. The second point is crucial for an adaptive robot to acquire new invariances in non-stationary environments, as demonstrated by the inverting glass experiments of Helmholtz. We will introduce Pavlovian conditioning circuits in our future work for the precise objective of achieving the generation, coordination, and internalization

  2. Optical Mining of Asteroids, Moons, and Planets to Enable Sustainable Human Exploration and Space Industrialization

    Data.gov (United States)

    National Aeronautics and Space Administration — PROBLEM, DEEP SPACE HUMAN EXPLORATION IS UNAFFORDABLE: In 2014 the NASA Advisory Council issued a finding that “The mismatch between NASA’s aspirations for human...

  3. International petroleum licensing, exploration activity and fiscal terms

    International Nuclear Information System (INIS)

    Hodgshon, S.

    1994-01-01

    Although there is no decline in current international petroleum licensing activity, attention is drawn to the fact that it is concentrated in certain countries, many of them amongst the less geologically prospective. Among the factors other then geological prospectivity which promote a successful licensing and exploration environment, the most important is the fiscal terms offered. While countries which are highly prospective geologically may stiffen terms and still attract exploration companies because they feel they can make major discoveries, any decline in prospectivity needs to be accompanied by a matching change in fiscal terms to maintain interest. Less prospective countries which, hitherto, have created favourable investment conditions may however find that further declines cannot be reversed by attractive fiscal terms. (7 figures, 3 tables). (UK)

  4. Human rights education (HRE) and transnational activism

    NARCIS (Netherlands)

    Mihr, A.; Schmitz, Hans-Peter

    2007-01-01

    Transnational human rights activism occupies today a significant place in the practice and scholarship of current global affairs. This article reviews the past successes and limits of this activism and suggests Human Rights Education (HRE) as a strategic tool currently underutilized by activists and

  5. Monetary reward activates human prefrontal cortex

    International Nuclear Information System (INIS)

    Thut, G.; Roelcke, U.; Nienhusmeier, M.; Missimer, J.; Maguire, R.P.; Leenders, K.L.; Schultz, W.

    1997-01-01

    We present a rCBF PET activation study, in which we demonstrated that reward processing in humans activates a cortical-subcortical network including dorsolateral prefrontal, orbital frontal, thalamic and midbrain regions. It is suggested that, as found for non-human primates, the basal ganglia-thalamo-cortical system is implicated in reward processing. (author) 1 fig., 3 refs

  6. Mars - The relationship of robotic and human elements in the IAA International Exploration of Mars study

    Science.gov (United States)

    Marov, Mikhail YA.; Duke, Michael B.

    1993-01-01

    The roles of human and robotic missions in Mars exploration are defined in the context of the short- and long-term Mars programs. In particular, it is noted that the currently implemented and planned missions to Mars can be regarded as robotic precursor missions to human exploration. Attention is given to factors that must be considered in formulating the rationale for human flights to Mars and future human Mars settlements and justifying costly projects.

  7. The Age of Human-Robot Collaboration: Deep Sea Exploration

    KAUST Repository

    Khatib, Oussama

    2018-01-01

    The promise of oceanic discovery has intrigued scientists and explorers for centuries, whether to study underwater ecology and climate change, or to uncover natural resources and historic secrets buried deep at archaeological sites. Reaching

  8. International oil and gas exploration and development activities

    Energy Technology Data Exchange (ETDEWEB)

    1990-10-29

    This report is part of an ongoing series of quarterly publications that monitors discoveries of oil and natural gas in foreign countries and provides an analysis of the reserve additions that result. The report is prepared by the Energy Information Administration (EIA) of the US Department of Energy (DOE) under the Foreign Energy Supply Assessment Program (FESAP). It presents a summary of discoveries and reserve additions that result from recent international exploration and development activities. It is intended for use by petroleum industry analysts, various government agencies, and political leaders in the development, implementation, and evaluation of energy plans, policy, and legislation. 25 refs., 8 figs., 4 tabs.

  9. Brain Activity and Human Unilateral Chewing

    Science.gov (United States)

    Quintero, A.; Ichesco, E.; Myers, C.; Schutt, R.; Gerstner, G.E.

    2012-01-01

    Brain mechanisms underlying mastication have been studied in non-human mammals but less so in humans. We used functional magnetic resonance imaging (fMRI) to evaluate brain activity in humans during gum chewing. Chewing was associated with activations in the cerebellum, motor cortex and caudate, cingulate, and brainstem. We also divided the 25-second chew-blocks into 5 segments of equal 5-second durations and evaluated activations within and between each of the 5 segments. This analysis revealed activation clusters unique to the initial segment, which may indicate brain regions involved with initiating chewing. Several clusters were uniquely activated during the last segment as well, which may represent brain regions involved with anticipatory or motor events associated with the end of the chew-block. In conclusion, this study provided evidence for specific brain areas associated with chewing in humans and demonstrated that brain activation patterns may dynamically change over the course of chewing sequences. PMID:23103631

  10. Carboxypeptidase activity in human mycoplasmas.

    OpenAIRE

    Shibata, K; Watanabe, T

    1986-01-01

    Mycoplasma salivarium produced citrulline, ammonia, and ATP from N-benzoylglycyl-L-arginine. The activity was inhibited by EDTA and was therefore concluded to be due to an arginine-specific carboxypeptidase. The activity was also found to exist in M. orale, M. buccale, M. faucium, and M. hominis.

  11. Teaching exploration and practice of the human body structure course

    Institute of Scientific and Technical Information of China (English)

    Feng LI; Ming-feng CHEN; Wen-long DING

    2015-01-01

    In the 21 st century,the medical model has transformed from the biological model to the biopsycho-social medical model. The transformation of medical model raises higher requirements for the training of medical staff. Comprehensive promotion of the reform of medical education has become the consensus and trend,which breeds the integrated medical teaching that is based on modules and organ systems. As one of eight integrated modules,the human body structure course of Shanghai Jiao Tong University School of Medicine introduces morphological structures of normal human organs according to function systems( such as locomotor system,digestive system,angiological system,and nervous system) of human organs and parts of human body. This course endeavors to integrate theories with practices,contents of disciplines of basic medicine,and basic medicine with clinical medicine. The human body structure course combines basic medicine with clinical medicine and is an important part of medical science.

  12. An exploration of physical activity and wellbeing in university employees.

    Science.gov (United States)

    Cooper, Kay; Barton, Gillian C

    2016-05-01

    The aim was to explore levels of physical activity (PA) and mental wellbeing in university employees, as well as barriers to and incentives for workplace PA. An electronic survey was distributed to all staff at one UK university. The survey consisted of a PA stages of change questionnaire, an international PA questionnaire (short-form), the Warwick-Edinburgh Mental Well-being Scale (WEMWBS), questions on perceived barriers to and incentives for workplace PA, questions on methods of enhancing employee wellbeing and demographics. A self-selected sample participated in two focus groups to explore key themes arising from the survey. Descriptive statistics were reported for survey data; associations between PA and wellbeing were tested for using Kruskal-Wallis with post hoc Mann-Whitney. Descriptive, thematic analysis was performed on focus group transcripts. A total of 502 surveys were completed (34% response rate); 13 staff participated in focus groups. In all, 42% of the sample reported PA below the recommended guideline amount. Females were less active than males (p wellbeing. University staff demonstrate PA levels and a relationship between PA and wellbeing similar to the general population. Carefully designed strategies aimed at enhancing PA and wellbeing in university staff are required. The specific cultural and other barriers to workplace PA that exist in this setting should be considered. These results are being used to inform PA and wellbeing interventions whose effectiveness will be evaluated in future research. © Royal Society for Public Health 2015.

  13. Active Exploration of Large 3D Model Repositories.

    Science.gov (United States)

    Gao, Lin; Cao, Yan-Pei; Lai, Yu-Kun; Huang, Hao-Zhi; Kobbelt, Leif; Hu, Shi-Min

    2015-12-01

    With broader availability of large-scale 3D model repositories, the need for efficient and effective exploration becomes more and more urgent. Existing model retrieval techniques do not scale well with the size of the database since often a large number of very similar objects are returned for a query, and the possibilities to refine the search are quite limited. We propose an interactive approach where the user feeds an active learning procedure by labeling either entire models or parts of them as "like" or "dislike" such that the system can automatically update an active set of recommended models. To provide an intuitive user interface, candidate models are presented based on their estimated relevance for the current query. From the methodological point of view, our main contribution is to exploit not only the similarity between a query and the database models but also the similarities among the database models themselves. We achieve this by an offline pre-processing stage, where global and local shape descriptors are computed for each model and a sparse distance metric is derived that can be evaluated efficiently even for very large databases. We demonstrate the effectiveness of our method by interactively exploring a repository containing over 100 K models.

  14. 78 FR 20696 - NASA Advisory Council; Human Exploration and Operations Committee; Research Subcommittee; Meeting

    Science.gov (United States)

    2013-04-05

    ... topics: --Overview of Research in Space Life and Physical Sciences --Space Station and Future Exploration... Exploration and Operations Committee; Research Subcommittee; Meeting AGENCY: National Aeronautics and Space... of the Research Subcommittee of the Human Exploration and Operations Committee (HEOC) of the NASA...

  15. Teachers' Pedagogical Perspectives and Teaching Practices on Human Rights in Cyprus: An Empirical Exploration and Implications for Human Rights Education

    Science.gov (United States)

    Zembylas, Michalinos; Charalambous, Constadina; Charalambous, Panayiota

    2016-01-01

    This paper describes a qualitative study that explored the understandings of human rights, pedagogical perspectives and practices in human rights teaching of three Greek-Cypriot elementary teachers. The study revealed some significant challenges in human rights teaching that seemed to be common for all three participating teachers. First, all of…

  16. Human-Robot Site Survey and Sampling for Space Exploration

    Science.gov (United States)

    Fong, Terrence; Bualat, Maria; Edwards, Laurence; Flueckiger, Lorenzo; Kunz, Clayton; Lee, Susan Y.; Park, Eric; To, Vinh; Utz, Hans; Ackner, Nir

    2006-01-01

    NASA is planning to send humans and robots back to the Moon before 2020. In order for extended missions to be productive, high quality maps of lunar terrain and resources are required. Although orbital images can provide much information, many features (local topography, resources, etc) will have to be characterized directly on the surface. To address this need, we are developing a system to perform site survey and sampling. The system includes multiple robots and humans operating in a variety of team configurations, coordinated via peer-to-peer human-robot interaction. In this paper, we present our system design and describe planned field tests.

  17. Exploring the implications of social change for human development: perspectives, issues and future directions.

    Science.gov (United States)

    Chen, Xinyin

    2015-02-01

    Researchers have investigated the implications of social change for human development from different perspectives. The studies published in this special section were conducted within Greenfield's theoretical framework (2009). The findings concerning links between specific sociodemographic features (e.g., commercial activities, schooling) and individual cognition and social behaviour are particularly interesting because they tap the underlying forces that drive human development. To further understand the issues in these studies and in the field, a pluralist-constructive perspective is discussed, which emphasises the integration of diverse values and practices in both Western and non-Western societies and its effects on the development of sophisticated competencies in individual adaptation to the changing global community. In addition, several issues are highlighted and some suggestions are provided for future explorations in this field. © 2014 International Union of Psychological Science.

  18. Exploring Formative Assessment Using Cultural Historical Activity Theory

    Directory of Open Access Journals (Sweden)

    Mandy Asghar

    2013-02-01

    Full Text Available Formative assessment is a pedagogic practice that has been the subject of much research and debate, as to how it can be used most effectively to deliver enhanced student learning in the higher education setting. Often described as a complex concept it embraces activities that range from facilitating students understanding of assessment standards, to providing formative feedback on their work; from very informal opportunities of engaging in conversations, to the very formal process of submitting drafts of work. This study aims to show how cultural historical activity theory can be used as a qualitative analysis framework to explore the complexities of formative assessment as it is used in higher education. The original data for the research was collected in 2008 by semi structured interviews and analysed using a hermeneutic phenomenological approach. For this present paper three selected transcripts were re-examined, using a case study approach that sought to understand and compare the perceptions of five academic staff, from three distinct subject areas taught within a UK university. It is proposed that using activity theory can provide insight into the complexity of such experiences, about what teachers do and why, and the influence of the community in which they are situated. Individually the cases from each subject area were analysed using activity theory exploring how the mediating artefacts of formative assessment were used; the often implicit rules that governed their use and the roles of teachers and students within the local subject community. The analysis also considered the influence each aspect of the unit of activity had on the other in understanding formative assessment practice. Subsequently the three subject cases were compared and contrasted. The findings illuminate a variety of practices, including how students and staff engage together in formative assessment activities and for some, how dialogue is used as one of the key tools

  19. Sensing Human Activity: GPS Tracking

    Science.gov (United States)

    van der Spek, Stefan; van Schaick, Jeroen; de Bois, Peter; de Haan, Remco

    2009-01-01

    The enhancement of GPS technology enables the use of GPS devices not only as navigation and orientation tools, but also as instruments used to capture travelled routes: as sensors that measure activity on a city scale or the regional scale. TU Delft developed a process and database architecture for collecting data on pedestrian movement in three European city centres, Norwich, Rouen and Koblenz, and in another experiment for collecting activity data of 13 families in Almere (The Netherlands) for one week. The question posed in this paper is: what is the value of GPS as ‘sensor technology’ measuring activities of people? The conclusion is that GPS offers a widely useable instrument to collect invaluable spatial-temporal data on different scales and in different settings adding new layers of knowledge to urban studies, but the use of GPS-technology and deployment of GPS-devices still offers significant challenges for future research. PMID:22574061

  20. Sensing Human Activity: GPS Tracking

    Directory of Open Access Journals (Sweden)

    Remco de Haan

    2009-04-01

    Full Text Available The enhancement of GPS technology enables the use of GPS devices not only as navigation and orientation tools, but also as instruments used to capture travelled routes: as sensors that measure activity on a city scale or the regional scale. TU Delft developed a process and database architecture for collecting data on pedestrian movement in three European city centres, Norwich, Rouen and Koblenz, and in another experiment for collecting activity data of 13 families in Almere (The Netherlands for one week. The question posed in this paper is: what is the value of GPS as ‘sensor technology’ measuring activities of people? The conclusion is that GPS offers a widely useable instrument to collect invaluable spatial-temporal data on different scales and in different settings adding new layers of knowledge to urban studies, but the use of GPS-technology and deployment of GPS-devices still offers significant challenges for future research.

  1. Vision of Space Exploration Possibilities and limits of a human space conquest.

    Science.gov (United States)

    Zelenyi, Lev

    Few generations of a schoolboys, which later become active and productive space researchers, have been brought up on a science fiction books. These books told us about travels to other Galaxies with velocities larger then velocity of light, meetings with friendly aliens (necessarily with communistic mentalities in Soviet Union books), star wars with ugly space monsters (in the western hemisphere books), etc. Beginning of Space age (4/10/1957) opened the door to a magic box, full of scientific discoveries, made mostly by robotic satellites and spacecraft. However, already the first human space trips clearly demonstrated that space is vigorously hostile to a human beings. Space medicine during the years since Gagarin flight, made an outstanding progress in supporting human presence at orbital stations, but the radiation hazards and problem of hypomagnetism are still opened and there is no visible path to their solution. So the optimistic slogan of 60-ies “Space is Our Place” is not supported by an almost half a century practice. Space never will be a comfortable place for soft and vulnerable humans? There is a general consensus that man will be on Mars during this century (or even its first part). This is very difficult but task it seems to be realistic after the significant advance of modern technologies will be made. But, is there any real need for humans to travel beyond the Mars orbit or to the inner regions of the Solar system? Will the age of Solar system exploration comes to its logical as it was described by Stanislav Lem in his famous book “Return from stars”? The author of this talk has more questions than answers, and thinks that PEX1 Panel on Exploration is just a right place to discuss these usually by passed topics.

  2. Assessing the Biohazard Potential of Putative Martian Organisms for Exploration Class Human Space Missions

    Science.gov (United States)

    Warmflash, David; Larios-Sanz, Maia; Jones, Jeffrey; Fox, George E.; McKay, David S.

    2007-01-01

    be an obstacle to human exploration. As a precaution, however, it is recommended that EVA suits be decontaminated when astronauts enter surface habitats when returning from field activity and that biosafety protocol approximating laboratory BSL 2 be developed for astronauts working in laboratories on the Martian surface. Quarantine of astronauts and Martian materials arriving on Earth should also be part of a human Mars mission and this and the surface biosafety program should be integral to human expeditions from the earliest stages of the mission planning.

  3. Pulmonary Inflammatory Responses to Acute Meteorite Dust Exposures - Implications for Human Space Exploration

    Science.gov (United States)

    Harrington, A. D.; McCubbin, F. M.; Vander Kaaden, K. E.; Kaur, J.; Smirnov, A.; Galdanes, K.; Schoonen, M. A. A.; Chen, L. C.; Tsirka, S. E.; Gordon, T.

    2018-01-01

    New initiatives to send humans to Mars within the next few decades are illustrative of the resurgence of interest in space travel. However, as with all exploration, there are risks. The Human Research Roadmap developed by NASA identifies the Risk of Adverse Health and Performance Effects of Celestial Dust Exposure as an area of concern. Extended human exploration will further increase the probability of inadvertent and repeated exposures to celestial dusts.

  4. Sensing human activity : GPS tracking

    NARCIS (Netherlands)

    van der Spek, Stefan; van Schaick, Jeroen; de Bois, P.G.; de Haan, Remco

    2009-01-01

    The enhancement of GPS technology enables the use of GPS devices not only as navigation and orientation tools, but also as instruments used to capture travelled routes: as sensors that measure activity on a city scale or the regional scale. TU Delft developed a process and database architecture for

  5. Drilling on the Moon and Mars: Developing the Science Approach for Subsurface Exploration with Human Crews

    Science.gov (United States)

    Stoker, C. R.; Zavaleta, J.; Bell, M.; Direto, S.; Foing, B.; Blake, D.; Kim, S.

    2010-01-01

    DOMEX (Drilling on the Moon and Mars in Human Exploration) is using analog missions to develop the approach for using human crews to perform science activities on the Moon and Mars involving exploration and sampling of the subsurface. Subsurface science is an important activity that may be uniquely enabled by human crews. DOMEX provides an opportunity to plan and execute planetary mission science activities without the expense and overhead of a planetary mission. Objectives: The objective of this first in a series of DOMEX missions were to 1) explore the regional area to understand the geologic context and determine stratigraphy and geologic history of various geologic units in the area. 2) Explore for and characterize sites for deploying a deep (10 m depth) drilling system in a subsequent field season. 3) Perform GPR on candidate drill sites. 4) Select sites that represent different geological units deposited in different epochs and collect soil cores using sterile procedures for mineralogical, organic and biological analysis. 5) Operate the MUM in 3 different sites representing different geological units and soil characteristics. 6) Collect rock and soil samples of sites visited and analyze them at the habitat. Results: At mission start the crew performed a regional survey to identify major geologic units that were correlated to recognized stratigraphy and regional geologic maps. Several candidate drill sites were identified. During the rest of the mission, successful GPR surveys were conducted in four locations. Soil cores were collected in 5 locations representing soils from 4 different geologic units, to depths up to 1m. Soil cores from two locations were analyzed with PCR in the laboratory. The remainder were reserved for subsequent analysis. XRD analysis was performed in the habitat and in the field on 39 samples, to assist with sample characterization, conservation, and archiving. MUM was deployed at 3 field locations and 1 test location (outside the

  6. Safety Characteristics in System Application Software for Human Rated Exploration

    Science.gov (United States)

    Mango, E. J.

    2016-01-01

    NASA and its industry and international partners are embarking on a bold and inspiring development effort to design and build an exploration class space system. The space system is made up of the Orion system, the Space Launch System (SLS) and the Ground Systems Development and Operations (GSDO) system. All are highly coupled together and dependent on each other for the combined safety of the space system. A key area of system safety focus needs to be in the ground and flight application software system (GFAS). In the development, certification and operations of GFAS, there are a series of safety characteristics that define the approach to ensure mission success. This paper will explore and examine the safety characteristics of the GFAS development.

  7. Planetary Boundaries: Exploring the Safe Operating Space for Humanity

    DEFF Research Database (Denmark)

    Richardson, Katherine; Rockström, Johan; Steffen, Will

    2009-01-01

    boundaries are rough, first estimates only, surrounded by large uncertainties and knowledge gaps. Filling these gaps will require major advancements in Earth System and resilience science. The proposed concept of "planetary boundaries" lays the groundwork for shifting our approach to governance...... and management, away from the essentially sectoral analyses of limits to growth aimed at minimizing negative externalities, toward the estimation of the safe space for human development. Planetary boundaries define, as it were, the boundaries of the "planetary playing field" for humanity if we want to be sure...

  8. Affinity purification of recombinant human plasminogen activator ...

    African Journals Online (AJOL)

    Affinity purification of recombinant human plasminogen activator from ... Screening antibody was performed using rhPA milk in an ELISA-elution assay. ... useful for purifying other tPA mutants or other novel recombinant milkderived proteins.

  9. A human activity approach to User Interfaces

    DEFF Research Database (Denmark)

    Bødker, Susanne

    1989-01-01

    the work situations in which computer-based artifacts are used: The framework deals with the role of the user interface in purposeful human work. Human activity theory is used in this analysis. The purpose of this article is to make the reader curious and hopefully open his or her eyes to a somewhat...

  10. Solar Energetic Particles Events and Human Exploration: Measurements in a Space Habitat

    Science.gov (United States)

    Narici, L.; Berrilli, F.; Casolino, M.; Del Moro, D.; Forte, R.; Giovannelli, L.; Martucci, M.; Mergè, M.; Picozza, P.; Rizzo, A.; Scardigli, S.; Sparvoli, R.; Zeitlin, C.

    2016-12-01

    Solar activity is the source of Space Weather disturbances. Flares, CME and coronal holes modulate physical conditions of circumterrestrial and interplanetary space and ultimately the fluxes of high-energy ionized particles, i.e., solar energetic particle (SEP) and galactic cosmic ray (GCR) background. This ionizing radiation affects spacecrafts and biological systems, therefore it is an important issue for human exploration of space. During a deep space travel (for example the trip to Mars) radiation risk thresholds may well be exceeded by the crew, so mitigation countermeasures must be employed. Solar particle events (SPE) constitute high risks due to their impulsive high rate dose. Forecasting SPE appears to be needed and also specifically tailored to the human exploration needs. Understanding the parameters of the SPE that produce events leading to higher health risks for the astronauts in deep space is therefore a first priority issue. Measurements of SPE effects with active devices in LEO inside the ISS can produce important information for the specific SEP measured, relative to the specific detector location in the ISS (in a human habitat with a shield typical of manned space-crafts). Active detectors can select data from specific geo-magnetic regions along the orbits, allowing geo-magnetic selections that best mimic deep space radiation. We present results from data acquired in 2010 - 2012 by the detector system ALTEA inside the ISS (18 SPEs detected). We compare this data with data from the detector Pamela on a LEO satellite, with the RAD data during the Curiosity Journey to Mars, with GOES data and with several Solar physical parameters. While several features of the radiation modulation are easily understood by the effect of the geomagnetic field, as an example we report a proportionality of the flux in the ISS with the energetic proton flux measured by GOES, some features appear more difficult to interpret. The final goal of this work is to find the

  11. Update on the Active Magnetospheric Particle Tracer Explorers (AMPTE) program

    International Nuclear Information System (INIS)

    Mcentire, R.W.

    1987-01-01

    The principles involved in the AMPTE mission's active experiments are discussed together with the role of the AMPTE satellites (the Germany's Ion Release Module, IRM, the United Kingdom Subsatellite, and the U.S Charge Composition Explorer, CCE) in and the results of the ion-release experiments. The AMPTE orbit profile is described, with the times of solar-wind and magnetotail ion releases (two barium and two lithium releases were carried out as the IRM precessed through the magnetosheath) shown schematically. In addition to the results on the Van Allen radiation belts obtained through the ion-release experiments, studies of the radiation belts with the new generation of sensors aboard the CCE and IRM are described. 25 references

  12. Planetary boundaries: exploring the safe operating space for humanity

    Science.gov (United States)

    Johan Rockström; Will Steffen; Kevin Noone; Asa Persson; F. Stuart Chapin; Eric Lambin; Timothy M. Lenton; Marten Scheffer; Carl Folke; Hans Joachim Schellnhuber; Björn Nykvist; Cynthia A. de Wit; Terry Hughes; Sander van der Leeuw; Henning Rodhe; Sverker Sörlin; Peter K. Snyder; Robert Costanza; Uno Svedin; Malin Falkenmark; Louise Karlberg; Robert W. Corell; Victoria J. Fabry; James Hansen; Brian Walker; Diana Liverman; Katherine Richardson; Paul Crutzen; Jonathan Foley

    2009-01-01

    Anthropogenic pressures on the Earth System have reached a scale where abrupt global environmental change can no longer be excluded. We propose a new approach to global sustainability in which we define planetary boundaries within which we expect that humanity can operate safely. Transgressing one or more planetary boundaries may be deleterious or even catastrophic due...

  13. Understanding Human Impact: Second Graders Explore Watershed Dynamics

    Science.gov (United States)

    Magruder, Robin; Rosenauer, Julia

    2016-01-01

    This article describes a second grade science enrichment unit with a focus on human impact, both positive and negative, on the living and nonliving components of the local watershed. Investigating the local watershed gave the unit a personal and pragmatic connection to students' lives because they depend on the local watershed for what they need…

  14. Exploring the Relevance of Holocaust Education for Human Rights Education

    Science.gov (United States)

    Eckmann, Monique

    2010-01-01

    Can Holocaust education be considered a tool for human rights education? If so, to what extent? These questions elicit discussions among a wide range of educators, and interest among politicians, educational planners, and ministries in charge of memorials. At first glance the obvious answer seems to be yes; both educators and students have strong…

  15. Near-Earth Asteroids: Destinations for Human Exploration

    Science.gov (United States)

    Barbee, Brent W.

    2014-01-01

    The Near-Earth Object Human Space Flight Accessible Targets Study (NHATS) is a system that monitors the near-Earth asteroid (NEA) population to identify NEAs whose orbital characteristics may make them potential destinations for future round-trip human space flight missions. To accomplish this monitoring, Brent Barbee (GSFC) developed and automated a system that applies specialized trajectory processing to the orbits of newly discovered NEAs, and those for which we have updated orbit knowledge, obtained from the JPL Small Bodies Database (SBDB). This automated process executes daily and the results are distributed to the general public and the astronomy community. This aids in prioritizing telescope radar time allocations for obtaining crucial follow-up observations of highly accessible NEAs during the critical, because it is often fleeting, time period surrounding the time at which the NEAs are initially discovered.

  16. Exploring Responsibility. Public and Private in Human Rights Protection

    OpenAIRE

    Bexell, Magdalena

    2005-01-01

    The theory and practice of international relations are replete with dilemmas related to the distribution of responsibility for human rights protection. Institutionalized notions of public and private empower and shape knowledge of what the spheres of responsibility signify for different kinds of actors. This study examines how the public-private distinction is manifested in controversy concerning the character of corporate social responsibility. The study develops a conceptual framework cente...

  17. Human resource crises in German hospitals?an explorative study

    OpenAIRE

    Schermuly, Carsten C; Draheim, Michael; Glasberg, Ronald; Stantchev, Vladimir; Tamm, Gerrit; Hartmann, Michael; Hessel, Franz

    2015-01-01

    Background The complexity of providing medical care in a high-tech environment with a highly specialized, limited labour force makes hospitals more crisis-prone than other industries. An effective defence against crises is only possible if the organizational resilience and the capacity to handle crises become part of the hospitals? organizational culture. To become more resilient to crises, a raised awareness?especially in the area of human resource (HR)?is necessary. The aim of this paper is...

  18. Human body contour data based activity recognition.

    Science.gov (United States)

    Myagmarbayar, Nergui; Yuki, Yoshida; Imamoglu, Nevrez; Gonzalez, Jose; Otake, Mihoko; Yu, Wenwei

    2013-01-01

    This research work is aimed to develop autonomous bio-monitoring mobile robots, which are capable of tracking and measuring patients' motions, recognizing the patients' behavior based on observation data, and providing calling for medical personnel in emergency situations in home environment. The robots to be developed will bring about cost-effective, safe and easier at-home rehabilitation to most motor-function impaired patients (MIPs). In our previous research, a full framework was established towards this research goal. In this research, we aimed at improving the human activity recognition by using contour data of the tracked human subject extracted from the depth images as the signal source, instead of the lower limb joint angle data used in the previous research, which are more likely to be affected by the motion of the robot and human subjects. Several geometric parameters, such as, the ratio of height to weight of the tracked human subject, and distance (pixels) between centroid points of upper and lower parts of human body, were calculated from the contour data, and used as the features for the activity recognition. A Hidden Markov Model (HMM) is employed to classify different human activities from the features. Experimental results showed that the human activity recognition could be achieved with a high correct rate.

  19. Exploring intercultural competence through an intercultural extracurricular activity in Taiwan

    Directory of Open Access Journals (Sweden)

    Liu Kai Li

    2016-01-01

    Full Text Available This study used interviews to explore how 10 Taiwanese college students' intercultural competence was developed after participating in an intercultural extracurricular activity designed with a purpose to facilitate foreign students’ study in Taiwan and to promote meaningful home-foreign student contacts. In-depth information and narratives from the interviews were collected as evidence of intercultural competence development. The results showed all the interviewees appreciated the experience and felt it to have been of value to them in terms of building international friendships, heightening their intercultural awareness and the benefits of intercultural competence, and having more appreciation and better understanding of Taiwanese culture. Students also realized that a lack of understanding of Taiwanese culture could exacerbate communication difficulties. Students thus became aware of the importance of describing Taiwanese cultural practices in English and realized that more language practice was necessary for smoother communication. Suggestions for both extracurricular activities and language programs improvement in the future were also provided in the conclusion.

  20. Active Learning for Directed Exploration of Complex Systems

    Science.gov (United States)

    Burl, Michael C.; Wang, Esther

    2009-01-01

    Physics-based simulation codes are widely used in science and engineering to model complex systems that would be infeasible to study otherwise. Such codes provide the highest-fidelity representation of system behavior, but are often so slow to run that insight into the system is limited. For example, conducting an exhaustive sweep over a d-dimensional input parameter space with k-steps along each dimension requires k(sup d) simulation trials (translating into k(sup d) CPU-days for one of our current simulations). An alternative is directed exploration in which the next simulation trials are cleverly chosen at each step. Given the results of previous trials, supervised learning techniques (SVM, KDE, GP) are applied to build up simplified predictive models of system behavior. These models are then used within an active learning framework to identify the most valuable trials to run next. Several active learning strategies are examined including a recently-proposed information-theoretic approach. Performance is evaluated on a set of thirteen synthetic oracles, which serve as surrogates for the more expensive simulations and enable the experiments to be replicated by other researchers.

  1. NASA Extreme Environment Mission Operations: Science Operations Development for Human Exploration

    Science.gov (United States)

    Bell, Mary S.

    2014-01-01

    The purpose of NASA Extreme Environment Mission Operations (NEEMO) mission 16 in 2012 was to evaluate and compare the performance of a defined series of representative near-Earth asteroid (NEA) extravehicular activity (EVA) tasks under different conditions and combinations of work systems, constraints, and assumptions considered for future human NEA exploration missions. NEEMO 16 followed NASA's 2011 Desert Research and Technology Studies (D-RATS), the primary focus of which was understanding the implications of communication latency, crew size, and work system combinations with respect to scientific data quality, data management, crew workload, and crew/mission control interactions. The 1-g environment precluded meaningful evaluation of NEA EVA translation, worksite stabilization, sampling, or instrument deployment techniques. Thus, NEEMO missions were designed to provide an opportunity to perform a preliminary evaluation of these important factors for each of the conditions being considered. NEEMO 15 also took place in 2011 and provided a first look at many of the factors, but the mission was cut short due to a hurricane threat before all objectives were completed. ARES Directorate (KX) personnel consulted with JSC engineers to ensure that high-fidelity planetary science protocols were incorporated into NEEMO mission architectures. ARES has been collaborating with NEEMO mission planners since NEEMO 9 in 2006, successively building upon previous developments to refine science operations concepts within engineering constraints; it is expected to continue the collaboration as NASA's human exploration mission plans evolve.

  2. Human Exploration Systems and Mobility Capability Roadmap Progress Review

    Science.gov (United States)

    Culbert, Chris; Taylor, Jeff

    2005-01-01

    Contents include the following: Capability Roadmap Team. Capability Description and Capability Breakdown Structure. Benefits of the Human Systems and Mobility Capability. Roadmap Process and Approach. Drivers and Assumptions for the whole team. Current State-of-the-Art, Assumptions and Requirements will be covered in the appropriate sections. Capability Presentations by Leads under Roadmap (Repeated for each capability under roadmap). Capability Description, Benefits, Current State-of-the-Art. Capability Requirements and Assumptions. Roadmap for Capability. Capability Readiness Level. Technology Readiness Level. Figures of Merit. Summary of Top Level Capability. Significant Technical Challenges. Summary and Forward Work.

  3. World uranium exploration, resources, production and related activities

    International Nuclear Information System (INIS)

    Hanly, A.

    2014-01-01

    A Nuclear Energy Series publication entitled “World Uranium Exploration, Resources, Production and Related Activities” (WUERPRA) will soon be published by the IAEA. The objective of the publication is to provide a comprehensive compilation of historic uranium exploration, resources, production and related activities based primarily on information from the 1966 to 2009 editions of the publication “Uranium Resources, Production and Demand”, a joint publication of the International Atomic Energy Agency and the Nuclear Energy Agency/Organization for Economic Cooperation and Development commonly known as the ‘Red Book’. This has been supplemented by historic information from other reliable sources. The publications also include, where enough information was available, descriptions of the relative potential for discovery of new uranium resources on a per country basis. To recover complete historic information it is frequently necessary to refer to earlier editions of the Red Book, many of which may not be readily available. This publication aims to provide one comprehensive source for much of this type of information which will reduce the effort required to prepare future editions of the Red Book, as well as make the historic Red Book information, together with select related information from other sources, more readily available to all users with an interest in uranium. WUERPRA comprises 6 volumes containing 164 country reports, each organized by region; Volume 1: Africa (53 countries); Volume 2: Central, Eastern and Southeastern Europe (25 countries); Volume 3: Southeastern Asia, Pacific, East Asia (18 countries); Volume 4: Western Europe (22 countries); Volume 5: Middle East, Central and Southern Asia (19 countries), and; Volume 6: North America, Central America and South America (27 countries). The report also contains information on countries that have not reported to the Red Book. The poster will summarize select major highlights from each volume

  4. Human activities affecting trace gases and climate

    International Nuclear Information System (INIS)

    Braatz, B.; Ebert, C.

    1990-01-01

    The Earth's climate has been in a constant state of change throughout geologic time due to natural perturbations in the global geobiosphere. However, various human activities have the potential to cause future global warming over a relatively short amount of time. These activities, which affect the Earth's climate by altering the concentrations of trace gases in the atmosphere, include energy consumption, particularly fossil-fuel consumption; industrial processes (production and use of chlorofluorocarbons, halons, and chlorocarbons, landfilling of wastes, and cement manufacture); changes in land use patterns, particularly deforestation and biomass burning; and agricultural practices (waste burning, fertilizer usage, rice production, and animal husbandry). Population growth is an important underlying factor affecting the level of growth in each activity. This paper describes how the human activities listed above contribute to atmospheric change, the current pattern of each activity, and how levels of each activity have changed since the early part of this century

  5. Exploring Entrainment Patterns of Human Emotion in Social Media

    Science.gov (United States)

    Luo, Chuan; Zhang, Zhu

    2016-01-01

    Emotion entrainment, which is generally defined as the synchronous convergence of human emotions, performs many important social functions. However, what the specific mechanisms of emotion entrainment are beyond in-person interactions, and how human emotions evolve under different entrainment patterns in large-scale social communities, are still unknown. In this paper, we aim to examine the massive emotion entrainment patterns and understand the underlying mechanisms in the context of social media. As modeling emotion dynamics on a large scale is often challenging, we elaborate a pragmatic framework to characterize and quantify the entrainment phenomenon. By applying this framework on the datasets from two large-scale social media platforms, we find that the emotions of online users entrain through social networks. We further uncover that online users often form their relations via dual entrainment, while maintain it through single entrainment. Remarkably, the emotions of online users are more convergent in nonreciprocal entrainment. Building on these findings, we develop an entrainment augmented model for emotion prediction. Experimental results suggest that entrainment patterns inform emotion proximity in dyads, and encoding their associations promotes emotion prediction. This work can further help us to understand the underlying dynamic process of large-scale online interactions and make more reasonable decisions regarding emergency situations, epidemic diseases, and political campaigns in cyberspace. PMID:26953692

  6. Exploring the world of human development and reproduction.

    Science.gov (United States)

    Red-Horse, Kristy; Drake, Penelope M; Fisher, Susan

    2014-01-01

    Susan Fisher has spent her career studying human development, proteomics, and the intersection between the two. When she began studying human placentation, there had been extensive descriptive studies of this fascinating organ that intertwines with the mother's vasculature during pregnancy. Susan can be credited with numerous major findings on the mechanisms that regulate placental cytotrophoblast invasion. These include the discovery that cytotrophoblasts undergo vascular mimicry to insert themselves into uterine arteries, the finding that oxygen tension greatly effects placentation, and identifying how these responses go awry in pregnancy complications such as preeclamsia. Other important work has focused on the effect of post-translational modifications such as glycosylation on bacterial adhesion and reproduction. Susan has also forayed into the world of proteomics to identify cancer biomarkers. Because her work is truly groundbreaking, many of these findings inspire research in other laboratories around the world resulting in numerous follow up papers. Likewise, her mentoring and support inspires young scientists to go on and make their own important discoveries. In this interview, Susan shares what drove her science, how she continued to do important research while balancing other aspects of life, and provides insights for the next generation.

  7. Exploring Entrainment Patterns of Human Emotion in Social Media.

    Science.gov (United States)

    He, Saike; Zheng, Xiaolong; Zeng, Daniel; Luo, Chuan; Zhang, Zhu

    2016-01-01

    Emotion entrainment, which is generally defined as the synchronous convergence of human emotions, performs many important social functions. However, what the specific mechanisms of emotion entrainment are beyond in-person interactions, and how human emotions evolve under different entrainment patterns in large-scale social communities, are still unknown. In this paper, we aim to examine the massive emotion entrainment patterns and understand the underlying mechanisms in the context of social media. As modeling emotion dynamics on a large scale is often challenging, we elaborate a pragmatic framework to characterize and quantify the entrainment phenomenon. By applying this framework on the datasets from two large-scale social media platforms, we find that the emotions of online users entrain through social networks. We further uncover that online users often form their relations via dual entrainment, while maintain it through single entrainment. Remarkably, the emotions of online users are more convergent in nonreciprocal entrainment. Building on these findings, we develop an entrainment augmented model for emotion prediction. Experimental results suggest that entrainment patterns inform emotion proximity in dyads, and encoding their associations promotes emotion prediction. This work can further help us to understand the underlying dynamic process of large-scale online interactions and make more reasonable decisions regarding emergency situations, epidemic diseases, and political campaigns in cyberspace.

  8. Exploring Entrainment Patterns of Human Emotion in Social Media.

    Directory of Open Access Journals (Sweden)

    Saike He

    Full Text Available Emotion entrainment, which is generally defined as the synchronous convergence of human emotions, performs many important social functions. However, what the specific mechanisms of emotion entrainment are beyond in-person interactions, and how human emotions evolve under different entrainment patterns in large-scale social communities, are still unknown. In this paper, we aim to examine the massive emotion entrainment patterns and understand the underlying mechanisms in the context of social media. As modeling emotion dynamics on a large scale is often challenging, we elaborate a pragmatic framework to characterize and quantify the entrainment phenomenon. By applying this framework on the datasets from two large-scale social media platforms, we find that the emotions of online users entrain through social networks. We further uncover that online users often form their relations via dual entrainment, while maintain it through single entrainment. Remarkably, the emotions of online users are more convergent in nonreciprocal entrainment. Building on these findings, we develop an entrainment augmented model for emotion prediction. Experimental results suggest that entrainment patterns inform emotion proximity in dyads, and encoding their associations promotes emotion prediction. This work can further help us to understand the underlying dynamic process of large-scale online interactions and make more reasonable decisions regarding emergency situations, epidemic diseases, and political campaigns in cyberspace.

  9. Exploring the Solar System with a Human Orrery

    Science.gov (United States)

    Newbury, Peter

    2010-01-01

    One of the fundamental learning goals of introductory astronomy is for the students to gain some perspective on the scale and structure of the solar system. Many astronomy teachers have laid out the planets along a long strip of paper or across a school grounds or campus. Other activities that investigate the motion of the planets are often…

  10. Cholesterol esterase activity of human intestinal mucosa

    International Nuclear Information System (INIS)

    Ponz de Leon, M.; Carubbi, F.; Di Donato, P.; Carulli, N.

    1985-01-01

    It has been suggested that cholesterol absorption in humans is dependent on bile acid pool composition and that expansion of the cholic acid pool size is followed by an increase of the absorption values. Similar observations were reported in rats. In the present study, therefore, the authors investigated some general properties of human intestinal cholesterol esterase, with particular emphasis on the effect of bile acids on this enzymatic activity. Twenty-nine segments of small intestine were taken during operations; the enzymatic activity was studied by using mucosal homogenate as a source of enzyme and oleic acid, cholesterol, and 14 C-labeled cholesterol as substrates. The time-activity relationship was linear within the first two hours; optimal pH for esterification ranged between 5 and 6.2. There was little difference between the esterifying activity of the jejunal and ileal mucosa. Esterification of cholesterol was observed with all the investigated fatty acids but was maximal with oleic acid. Bile acids did not affect cholesterol esterase activity when present in the incubation mixture at 0.1 and 1.0 mM; the enzymatic activity, however, was significantly inhibited when bile acids were added at 20 mM. In conclusion, this study has shown that the human intestinal mucosa possesses a cholesterol esterase activity; at variance with the rat, however, the human enzyme does not seem to be stimulated by trihydroxy bile acids

  11. Strategies for the sustained human exploration of Mars

    Science.gov (United States)

    Landau, Damon Frederick

    A variety of mission scenarios are compared in this thesis to assess the strengths and weaknesses of options for Mars exploration. The mission design space is modeled along two dimensions: trajectory architectures and propulsion system technologies. Direct, semi-direct, stop-over, semi-cycler, and cycler architectures are examined, and electric propulsion, nuclear thermal rockets, methane and oxygen production on Mars, Mars water excavation, aerocapture, and reusable propulsion systems are included in the technology assessment. The mission sensitivity to crew size, vehicle masses, and crew travel time is also examined. The primary figure of merit for a mission scenario is the injected mass to low-Earth orbit (IMLEO), though technology readiness levels (TRL) are also included. Several elements in the architecture dimension are explored in more detail. The Earth-Mars semi-cycler architecture is introduced and five families of Earth-Mars semi-cycler trajectories are presented along with optimized itineraries. Optimized cycler trajectories are also presented. In addition to Earth-Mars semi-cycler and cycler trajectories, conjunction-class, free-return, Mars-Earth semi-cycler, and low-thrust trajectories are calculated. Design parameters for optimal DeltaV trajectories are provided over a range of flight times (from 120 to 270 days) and launch years (between 2009 and 2022). Unlike impulsive transfers, the mass-optimal low-thrust trajectory depends strongly on the thrust and specific impulse of the propulsion system. A low-thrust version of the rocket equation is provided where the initial mass or thrust may be minimized by varying the initial acceleration and specific impulse. Planet-centered operations are also examined. A method to rotate a parking orbit about the line of apsides to achieve the proper orientation at departure is discussed, thus coupling the effects of parking-orbit orientation with the interplanetary trajectories. Also, a guidance algorithm for

  12. Human exploration of space: why, where, what for?

    Science.gov (United States)

    Vernikos, J

    2008-08-01

    "Man must rise above Earth to the top of the atmosphere and beyond, for only then will he fully understand the world in which he lives"-Socrates (469-399 BC). The basic driving rationales for human space flight (HSF) are rooted in age-old and persisting dreams. Fascination with the idea of people going into the sky for adventures in other worlds goes back to ancient myths. This paper sheds light onto criticisms of HSF programs, by revisiting their scientific grounds and associated benefits, along with the different types of emerging commercial enterprise. Research from space has lead to a wealth of commercial and societal applications on Earth, building up the case for the so-called "Space Applications Market".

  13. Exploration

    International Nuclear Information System (INIS)

    Lohrenz, J.

    1992-01-01

    Oil and gas exploration is a unique kind of business. Businesses providing a vast and ever-changing panoply of products to markets are a focus of several disciplines' energetic study and analysis. The product inventory problem is robust, pertinent, and meaningful, and it merits the voluminous and protracted attention received from keen business practitioners. Prototypical business practitioners, be they trained by years of business hurly-burly, or sophisticated MBAs with arrays of mathematical algorithms and computers, are not normally prepared, however, to recognize the unique nature of exploration's inventories. Put together such a business practitioner with an explorationist and misunderstandings, hidden and open, are inevitable and predictably rife. The first purpose of this paper is to articulate the inherited inventory handling paradigms of business practitioners in relation to exploration's inventories. To do so, standard pedagogy in business administration is used and a case study of an exploration venture is presented. A second purpose is to show the burdens that the misunderstandings create. The result is not just business plans that go awry, but public policies that have effects opposite from those intended

  14. Becoming Earth Independent: Human-Automation-Robotics Integration Challenges for Future Space Exploration

    Science.gov (United States)

    Marquez, Jessica J.

    2016-01-01

    Future exploration missions will require NASA to integrate more automation and robotics in order to accomplish mission objectives. This presentation will describe on the future challenges facing the human operator (astronaut, ground controllers) as we increase the amount of automation and robotics in spaceflight operations. It will describe how future exploration missions will have to adapt and evolve in order to deal with more complex missions and communication latencies. This presentation will outline future human-automation-robotic integration challenges.

  15. A New Presentation and Exploration of Human Cerebral Vasculature Correlated with Surface and Sectional Neuroanatomy

    Science.gov (United States)

    Nowinski, Wieslaw L.; Thirunavuukarasuu, Arumugam; Volkau, Ihar; Marchenko, Yevgen; Aminah, Bivi; Gelas, Arnaud; Huang, Su; Lee, Looi Chow; Liu, Jimin; Ng, Ting Ting; Nowinska, Natalia G.; Qian, Guoyu Yu; Puspitasari, Fiftarina; Runge, Val M.

    2009-01-01

    The increasing complexity of human body models enabled by advances in diagnostic imaging, computing, and growing knowledge calls for the development of a new generation of systems for intelligent exploration of these models. Here, we introduce a novel paradigm for the exploration of digital body models illustrating cerebral vasculature. It enables…

  16. Capability and Technology Performance Goals for the Next Step in Affordable Human Exploration of Space

    Science.gov (United States)

    Linne, Diane L.; Sanders, Gerald B.; Taminger, Karen M.

    2015-01-01

    The capability for living off the land, commonly called in-situ resource utilization, is finally gaining traction in space exploration architectures. Production of oxygen from the Martian atmosphere is called an enabling technology for human return from Mars, and a flight demonstration to be flown on the Mars 2020 robotic lander is in development. However, many of the individual components still require technical improvements, and system-level trades will be required to identify the best combination of technology options. Based largely on work performed for two recent roadmap activities, this paper defines the capability and technology requirements that will need to be achieved before this game-changing capability can reach its full potential.

  17. Smartphone-based human activity recognition

    OpenAIRE

    Reyes Ortiz, Jorge Luis

    2014-01-01

    Cotutela Universitat Politècnica de Catalunya i Università degli Studi di Genova Human Activity Recognition (HAR) is a multidisciplinary research field that aims to gather data regarding people's behavior and their interaction with the environment in order to deliver valuable context-aware information. It has nowadays contributed to develop human-centered areas of study such as Ambient Intelligence and Ambient Assisted Living, which concentrate on the improvement of people's Quality of Lif...

  18. Building a framework to explore water-human interaction for sustainable agro ecosystems in US Midwest

    Science.gov (United States)

    Mishra, S. K.; Ding, D.; Rapolu, U.

    2012-12-01

    Human activity is intricately linked to the quality and quantity of water resources. Although many studies have examined water-human interaction, the complexity of such coupled systems is not well understood largely because of gaps in our knowledge of water-cycle processes which are heavily influenced by socio-economic drivers. On this context, this team has investigated connections among agriculture, policy, climate, land use/land cover, and water quality in Iowa over the past couple of years. To help explore these connections the team is developing a variety of cyber infrastructure tools that facilitate the collection, analysis and visualization of data, and the simulation of system dynamics. In an ongoing effort, the prototype system is applied to Clear Creek watershed, an agricultural dominating catchment in Iowa in the US Midwest, to understand water-human processes relevant to management decisions by farmers regarding agro ecosystems. The primary aim of this research is to understand the connections that exist among the agricultural and biofuel economy, land use/land cover change, and water quality. To help explore these connections an agent-based model (ABM) of land use change has been developed that simulates the decisions made by farmers given alternative assumptions about market forces, farmer characteristics, and water quality regulations. The SWAT model was used to simulate the impact of these decisions on the movement of sediment, nitrogen, and phosphorus across the landscape. The paper also demonstrate how through the use of this system researchers can, for example, search for scenarios that lead to desirable socio-economic outcomes as well as preserve water quantity and quality.

  19. Advanced Nuclear Power Concepts for Human Exploration Missions

    International Nuclear Information System (INIS)

    Robert L. Cataldo; Lee S. Mason

    2000-01-01

    The design reference mission for the National Aeronautics and Space Administration's (NASA's) human mission to Mars supports a philosophy of living off the land in order to reduce crew risk, launch mass, and life-cycle costs associated with logistics resupply to a Mars base. Life-support materials, oxygen, water, and buffer gases, and the crew's ascent-stage propellant would not be brought from Earth but rather manufactured from the Mars atmosphere. The propellants would be made over ∼2 yr, the time between Mars mission launch window opportunities. The production of propellants is very power intensive and depends on type, amount, and time to produce the propellants. Closed-loop life support and food production are also power intensive. With the base having several habitats, a greenhouse, and propellant production capability, total power levels reach well over 125 kW(electric). The most mass-efficient means of satisfying these requirements is through the use of nuclear power. Studies have been performed to identify a potential system concept, described in this paper, using a mobile cart to transport the power system away from the Mars lander and provide adequate separation between the reactor and crew. The studies included an assessment of reactor and power conversion technology options, selection of system and component redundancy, determination of optimum separation distance, and system performance sensitivity to some key operating parameters

  20. Reconstruction, visualization and explorative analysis of human pluripotency network

    Directory of Open Access Journals (Sweden)

    Priyanka Narad

    2017-09-01

    Full Text Available Identification of genes/proteins involved in pluripotency and their inter-relationships is important for understanding the induction/loss and maintenance of pluripotency. With the availability of large volume of data on interaction/regulation of pluripotency scattered across a large number of biological databases and hundreds of scientific journals, it is required a systematic integration of data which will create a complete view of pluripotency network. Describing and interpreting such a network of interaction and regulation (i.e., stimulation and inhibition links are essential tasks of computational biology, an important first step in systems-level understanding of the underlying mechanisms of pluripotency. To address this, we have assembled a network of 166 molecular interactions, stimulations and inhibitions, based on a collection of research data from 147 publications, involving 122 human genes/proteins, all in a standard electronic format, enabling analyses by readily available software such as Cytoscape and its Apps (formerly called "Plugins". The network includes the core circuit of OCT4 (POU5F1, SOX2 and NANOG, its periphery (such as STAT3, KLF4, UTF1, ZIC3, and c-MYC, connections to upstream signaling pathways (such as ACTIVIN, WNT, FGF, and BMP, and epigenetic regulators (such as L1TD1, LSD1 and PRC2. We describe the general properties of the network and compare it with other literature-based networks. Gene Ontology (GO analysis is being performed to find out the over-represented GO terms in the network. We use several expression datasets to condense the network to a set of network links that identify the key players (genes/proteins and the pathways involved in transition from one state of pluripotency to other state (i.e., native to primed state, primed to non-pluripotent state and pluripotent to non-pluripotent state.

  1. Human resource crises in German hospitals--an explorative study.

    Science.gov (United States)

    Schermuly, Carsten C; Draheim, Michael; Glasberg, Ronald; Stantchev, Vladimir; Tamm, Gerrit; Hartmann, Michael; Hessel, Franz

    2015-05-28

    The complexity of providing medical care in a high-tech environment with a highly specialized, limited labour force makes hospitals more crisis-prone than other industries. An effective defence against crises is only possible if the organizational resilience and the capacity to handle crises become part of the hospitals' organizational culture. To become more resilient to crises, a raised awareness--especially in the area of human resource (HR)--is necessary. The aim of this paper is to contribute to the process robustness against crises through the identification and evaluation of relevant HR crises and their causations in hospitals. Qualitative and quantitative methods were combined to identify and evaluate crises in hospitals in the HR sector. A structured workshop with experts was conducted to identify HR crises and their descriptions, as well as causes and consequences for patients and hospitals. To evaluate the findings, an online survey was carried out to rate the occurrence (past, future) and dangerousness of each crisis. Six HR crises were identified in this study: staff shortages, acute loss of personnel following a pandemic, damage to reputation, insufficient communication during restructuring, bullying, and misuse of drugs. The highest occurrence probability in the future was seen in staff shortages, followed by acute loss of personnel following a pandemic. Staff shortages, damage to reputation, and acute loss of personnel following a pandemic were seen as the most dangerous crises. The study concludes that coping with HR crises in hospitals is existential for hospitals and requires increased awareness. The six HR crises identified occurred regularly in German hospitals in the past, and their occurrence probability for the future was rated as high.

  2. HExpoChem: a systems biology resource to explore human exposure to chemicals

    DEFF Research Database (Denmark)

    Taboureau, Olivier; Jacobsen, Ulrik Plesner; Kalhauge, Christian Gram

    2013-01-01

    of computational biology approaches are needed to assess the health risks of chemical exposure. Here we present HExpoChem, a tool based on environmental chemicals and their bioactivities on human proteins with the objective of aiding the qualitative exploration of human exposure to chemicals. The chemical...

  3. Explore the Human-Based Teaching for the Professional Course of Materials Science and Engineering

    Science.gov (United States)

    Zhao, Yiping; Chen, Li; Zhang, Yufeng

    2008-01-01

    As viewed from two sides such as teacher and student, in this article, we explore the human-based teaching reform for the college professional course of materials Science and Engineering, point out the qualities and conditions that professional teacher should possess in the process of human-based teaching reform of professional course and the…

  4. Concept Design of High Power Solar Electric Propulsion Vehicles for Human Exploration

    Science.gov (United States)

    Hoffman, David J.; Kerslake, Thomas W.; Hojnicki, Jeffrey S.; Manzella, David H.; Falck, Robert D.; Cikanek, Harry A., III; Klem, Mark D.; Free, James M.

    2011-01-01

    Human exploration beyond low Earth orbit will require enabling capabilities that are efficient, affordable and reliable. Solar electric propulsion (SEP) has been proposed by NASA s Human Exploration Framework Team as one option to achieve human exploration missions beyond Earth orbit because of its favorable mass efficiency compared to traditional chemical propulsion systems. This paper describes the unique challenges associated with developing a large-scale high-power (300-kWe class) SEP vehicle and design concepts that have potential to meet those challenges. An assessment of factors at the subsystem level that must be considered in developing an SEP vehicle for future exploration missions is presented. Overall concepts, design tradeoffs and pathways to achieve development readiness are discussed.

  5. Innovative Technologies for Human Exploration: Opportunities for Partnerships and Leveraging Novel Technologies External to NASA

    Science.gov (United States)

    Hay, Jason; Mullins, Carie; Graham, Rachael; Williams-Byrd, Julie; Reeves, John D.

    2011-01-01

    Human spaceflight organizations have ambitious goals for expanding human presence throughout the solar system. To meet these goals, spaceflight organizations have to overcome complex technical challenges for human missions to Mars, Near Earth Asteroids, and other distant celestial bodies. Resolving these challenges requires considerable resources and technological innovations, such as advancements in human health and countermeasures for space environments; self-sustaining habitats; advanced power and propulsion systems; and information technologies. Today, government space agencies seek cooperative endeavors to reduce cost burdens, improve human exploration capabilities, and foster knowledge sharing among human spaceflight organizations. This paper looks at potential opportunities for partnerships and spin-ins from economic sectors outside the space industry. It highlights innovative technologies and breakthrough concepts that could have significant impacts on space exploration and identifies organizations throughout the broader economy that specialize in these technologies.

  6. Crew systems: integrating human and technical subsystems for the exploration of space

    Science.gov (United States)

    Connors, M. M.; Harrison, A. A.; Summit, J.

    1994-01-01

    Space exploration missions will require combining human and technical subsystems into overall "crew systems" capable of performing under the rigorous conditions of outer space. This report describes substantive and conceptual relationships among humans, intelligent machines, and communication systems, and explores how these components may be combined to complement and strengthen one another. We identify key research issues in the combination of humans and technology and examine the role of individual differences, group processes, and environmental conditions. We conclude that a crew system is, in effect, a social cyborg, a living system consisting of multiple individuals whose capabilities are extended by advanced technology.

  7. The Future of Asset Management for Human Space Exploration: Supply Classification and an Integrated Database

    Science.gov (United States)

    Shull, Sarah A.; Gralla, Erica L.; deWeck, Olivier L.; Shishko, Robert

    2006-01-01

    One of the major logistical challenges in human space exploration is asset management. This paper presents observations on the practice of asset management in support of human space flight to date and discusses a functional-based supply classification and a framework for an integrated database that could be used to improve asset management and logistics for human missions to the Moon, Mars and beyond.

  8. Peer-to-Peer Human-Robot Interaction for Space Exploration

    Science.gov (United States)

    Fong, Terrence; Nourbakhsh, Illah

    2004-01-01

    NASA has embarked on a long-term program to develop human-robot systems for sustained, affordable space exploration. To support this mission, we are working to improve human-robot interaction and performance on planetary surfaces. Rather than building robots that function as glorified tools, our focus is to enable humans and robots to work as partners and peers. In this paper. we describe our approach, which includes contextual dialogue, cognitive modeling, and metrics-based field testing.

  9. Food & Fitness. Directory. Human Nutrition Activities.

    Science.gov (United States)

    Department of Agriculture, Washington, DC.

    Activities of the following regulatory and food service agencies of the Department of Agriculture are described: (1) Agricultural Research Service; (2) Cooperative State Research Service; (3) Economic Research Service; (4) Human Nutrition Information Service; (5) Office of Grants and Program Systems; (6) Office of International Cooperation and…

  10. BACTERICIDAL ACTIVITY OF HUMAN SERA AGAINST ...

    African Journals Online (AJOL)

    hi-tech

    East African Medical Journal Vol. 77 No. 12 December 2000. BACTERICIDAL ACTIVITY OF HUMAN SERA AGAINST SALMONELLA TYPHI AND SALMONELLA PARATYPHI A, B, C. E.O. Igumbor, BSc, MSc, PhD, Department of Medical Microbiology, School of Medicine, University of Zimbabwe P.O. Box Al78, Avondale, ...

  11. Funding and Strategic Alignment Guidance for Infusing Small Business Innovation Research Technology Into Human Exploration and Operations Mission Directorate Projects for 2016

    Science.gov (United States)

    Nguyen, Hung D.; Steele, Gynelle C.

    2017-01-01

    This report is intended to help NASA program and project managers incorporate Small Business Innovation Research Small Business Technology Transfer (SBIR/STTR) technologies into NASA Human Exploration and Operations Mission Directorate (HEOMD) projects. Other Government and commercial projects managers can also find this useful. Space Transportation; Life Support and Habitation Systems; Extra-Vehicular Activity; High EfficiencySpace Power; Human Exploration and Operations Mission,

  12. Real-time Human Activity Recognition

    Science.gov (United States)

    Albukhary, N.; Mustafah, Y. M.

    2017-11-01

    The traditional Closed-circuit Television (CCTV) system requires human to monitor the CCTV for 24/7 which is inefficient and costly. Therefore, there’s a need for a system which can recognize human activity effectively in real-time. This paper concentrates on recognizing simple activity such as walking, running, sitting, standing and landing by using image processing techniques. Firstly, object detection is done by using background subtraction to detect moving object. Then, object tracking and object classification are constructed so that different person can be differentiated by using feature detection. Geometrical attributes of tracked object, which are centroid and aspect ratio of identified tracked are manipulated so that simple activity can be detected.

  13. Learning in Activity: Exploring the Methodological Potential of Action Research in Activity Theorising of Social Practice

    Science.gov (United States)

    Darwin, Stephen

    2011-01-01

    Cultural-historical activity theory (CHAT), founded on the seminal work of Vygotsky and evolving in the subsequent work of Leont'ev and Engestrom, continues to emerge as a robust and increasingly widely used conceptual framework for the research and analysis of the complex social mediation of human learning and development. Yet there remains…

  14. Human Exploration Using Real-Time Robotic Operations (HERRO)- Crew Telerobotic Control Vehicle (CTCV) Design

    Science.gov (United States)

    Oleson, Steven R.; McGuire, Melissa L.; Burke, Laura; Chato, David; Fincannon, James; Landis, Geoff; Sandifer, Carl; Warner, Joe; Williams, Glenn; Colozza, Tony; hide

    2010-01-01

    The HERRO concept allows real time investigation of planets and small bodies by sending astronauts to orbit these targets and telerobotically explore them using robotic systems. Several targets have been put forward by past studies including Mars, Venus, and near Earth asteroids. A conceptual design study was funded by the NASA Innovation Fund to explore what the HERRO concept and it's vehicles would look like and what technological challenges need to be met. This design study chose Mars as the target destination. In this way the HERRO studies can define the endpoint design concepts for an all-up telerobotic exploration of the number one target of interest Mars. This endpoint design will serve to help planners define combined precursor telerobotics science missions and technology development flights. A suggested set of these technologies and demonstrator missions is shown in Appendix B. The HERRO concept includes a crewed telerobotics orbit vehicle as well three Truck rovers, each supporting two teleoperated geologist robots Rockhounds (each truck/Rockhounds set is landed using a commercially launched aeroshell landing system.) Options include a sample ascent system teamed with an orbital telerobotic sample rendezvous and return spacecraft (S/C) (yet to be designed). Each truck rover would be landed in a science location with the ability to traverse a 100 km diameter area, carrying the Rockhounds to 100 m diameter science areas for several week science activities. The truck is not only responsible for transporting the Rockhounds to science areas, but also for relaying telecontrol and high-res communications to/from the Rockhound and powering/heating the Rockhound during the non-science times (including night-time). The Rockhounds take the place of human geologists by providing an agile robotic platform with real-time telerobotics control to the Rockhound from the crew telerobotics orbiter. The designs of the Truck rovers and Rockhounds will be described in other

  15. Towards human exploration of space: the THESEUS review series on neurophysiology research priorities.

    Science.gov (United States)

    White, Olivier; Clément, Gilles; Fortrat, Jacques-Olivier; Pavy-LeTraon, Anne; Thonnard, Jean-Louis; Blanc, Stéphane; Wuyts, Floris L; Paloski, William H

    2016-01-01

    The THESEUS project (Towards Human Exploration of Space: a European Strategy), initiated within the seventh Framework Programme by the European Commission, aimed at providing a cross-cutting, life-science-based roadmap for Europe's strategy towards human exploration of long space missions, and its relevance to applications on Earth. This topic was investigated by experts in the field, in the framework of the THESEUS project whose aim was to develop an integrated life sciences research roadmap regarding human space exploration. In particular, decades of research have shown that altered gravity impairs neurological responses at large, such as perception, sleep, motor control, and cognitive factors. International experts established a list of key issues that should be addressed in that context and provided several recommendations such as a maximal exploitation of currently available resources on Earth and in space.

  16. Human Exploration Ethnography of the Haughton-Mars Project, 1998-1999

    Science.gov (United States)

    Clancey, William J.; Swanson, Keith (Technical Monitor)

    1999-01-01

    During the past two field seasons, July 1988 and 1999, we have conducted research about the field practices of scientists and engineers at Haughton Crater on Devon Island in the Canadian Arctic, with the objective of determining how people will live and work on Mars. This broad investigation of field life and work practice, part of the Haughton-Mars Project lead by Pascal Lee, spans social and cognitive anthropology, psychology, and computer science. Our approach involves systematic observation and description of activities, places, and concepts, constituting an ethnography of field science at Haughton. Our focus is on human behaviors-what people do, where, when, with whom, and why. By locating behavior in time and place-in contrast with a purely functional or "task oriented" description of work-we find patterns constituting the choreography of interaction between people, their habitat, and their tools. As such, we view the exploration process in terms of a total system comprising a social organization, facilities, terrain/climate, personal identities, artifacts, and computer tools. Because we are computer scientists seeking to develop new kinds of tools for living and working on Mars, we focus on the existing representational tools (such as documents and measuring devices), learning and improvization (such as use of the internet or informal assistance), and prototype computational systems brought to the field. Our research is based on partnership, by which field scientists and engineers actively contribute to our findings, just as we participate in their work and life.

  17. Actual Uranium Exploration and Mining Activities in Niger

    International Nuclear Information System (INIS)

    Kache, Mamane

    2014-01-01

    Conclusion: Since the Fukushima nuclear power plant accident in 2011, many mining companies are not interested in uranium. It leads to the decrease in uranium spot price and the delay of IMOURAREN Project. Only, 47 exploration licenses for 12 mining companies are now valid in Niger.

  18. Towards human exploration of space: the THESEUS review series on muscle and bone research priorities.

    Science.gov (United States)

    Lang, Thomas; Van Loon, Jack J W A; Bloomfield, Susan; Vico, Laurence; Chopard, Angele; Rittweger, Joern; Kyparos, Antonios; Blottner, Dieter; Vuori, Ilkka; Gerzer, Rupert; Cavanagh, Peter R

    2017-01-01

    Without effective countermeasures, the musculoskeletal system is altered by the microgravity environment of long-duration spaceflight, resulting in atrophy of bone and muscle tissue, as well as in deficits in the function of cartilage, tendons, and vertebral disks. While inflight countermeasures implemented on the International Space Station have evidenced reduction of bone and muscle loss on low-Earth orbit missions of several months in length, important knowledge gaps must be addressed in order to develop effective strategies for managing human musculoskeletal health on exploration class missions well beyond Earth orbit. Analog environments, such as bed rest and/or isolation environments, may be employed in conjunction with large sample sizes to understand sex differences in countermeasure effectiveness, as well as interaction of exercise with pharmacologic, nutritional, immune system, sleep and psychological countermeasures. Studies of musculoskeletal biomechanics, involving both human subject and computer simulation studies, are essential to developing strategies to avoid bone fractures or other injuries to connective tissue during exercise and extravehicular activities. Animal models may be employed to understand effects of the space environment that cannot be modeled using human analog studies. These include studies of radiation effects on bone and muscle, unraveling the effects of genetics on bone and muscle loss, and characterizing the process of fracture healing in the mechanically unloaded and immuno-compromised spaceflight environment. In addition to setting the stage for evidence-based management of musculoskeletal health in long-duration space missions, the body of knowledge acquired in the process of addressing this array of scientific problems will lend insight into the understanding of terrestrial health conditions such as age-related osteoporosis and sarcopenia.

  19. Exploration and production activities and market - Panorama 2008; Activites et marches en exploration-production - Panorama 2008

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    Following two banner years for the oil service and supply sector, marked by strong activity and a substantial increase in prices, the Exploration and Production market continued at a frenetic pace in 2007, although certain local markets retreated. In 2008, activity should stay high and prices should start stabilizing. With services in short supply, companies in the sector have been able to shift the balance of power with oil firms in their favor.

  20. Neighbors Connected; Exploring Recruitment of Dutch Older People for Activities

    NARCIS (Netherlands)

    Lezwijn, J.; Vaandrager, L.; Wagemakers, A.; Koelen, M.; Woerkum, van C.

    2015-01-01

    The recruitment of older people to engage in actions aimed at promoting health is an issue that does not receive much attention within health promotion practice. Many activities for older people are organized; however, less socially active older people do not participate in such activities. The aim

  1. Monitoring Human Activity through Portable Devices

    Directory of Open Access Journals (Sweden)

    G. Sebestyen

    2012-06-01

    Full Text Available Monitoring human activity may be useful for medical supervision and for prophylactic purposes. Mobile devices like intelligent phones or watches have multiple sensors and wireless communication capabilities which can be used for this purpose. This paper presents some integrated solutions for determining and continuous monitoring of a person’s state. Aspects taken into consideration are: activity detection and recognition based on acceleration sensors, wireless communication protocols for data acquisition, web monitoring, alerts generation and statistical processing of multiple sensorial data. As practical implementations two case studies are presented, one using an intelligent phone and another using a mixed signal processor integrated in a watch.

  2. Effect of losartan on human platelet activation.

    Science.gov (United States)

    Guerra-Cuesta, J I; Montón, M; Rodríguez-Feo, J A; Jiménez, A M; González-Fernández, F; Rico, L A; García, R; Gómez, J; Farré, J; Casado, S; López-Farré, A

    1999-03-01

    Previous studies have demonstrated that losartan can block the thromboxane A2 receptor on the vascular wall. The aim of the present study was to assess the effect of losartan on human platelet activation. Platelets were obtained from 15 healthy men, aged 26-40 years. Platelet activation was measured by changes in the light transmission of platelet-rich plasma stimulated by the thromboxane A2 analog U46619 (5 x 10(-6) mol/l) or ADP (10(-5) mol/l). U46619-stimulated platelet aggregation was significantly inhibited by losartan in a dose-dependent manner. Only a high dose of EXP 3174 (5 x 10(-5) mol/l), the in vivo active metabolite of losartan, was able to attenuate U46619-induced platelet activation. Captopril, an angiotensin I converting inhibitor, failed to modify U46619-induced platelet aggregation. Furthermore, the binding of [3H]-U46619 to platelets was competitively inhibited by losartan, whereas only a high dose of EXP 3174 reduced the binding of [3H]-U46619. Captopril failed to modify the binding of [3H]-U46619 to platelets. Losartan also reduced the platelet activation induced by ADP (10(-5) mol/l), a platelet agonist partially dependent on thromboxane A2. In addition, when thromboxane A2 generation was blocked by aspirin, ADP-induced platelet aggregation was inhibited to a similar degree to the inhibition induced by losartan. Exogenous angiotensin II did not elicit any modification of either U46619- or ADP-stimulated platelet aggregation. Losartan decreased platelet aggregation by a thromboxane A2-dependent mechanism. EXP 3174 was less potent than losartan in reducing thromboxane A2-dependent platelet activation. Captopril and exogenous angiotensin II had no effect on human platelet activation. These results suggest that losartan reduced thromboxane A2-dependent platelet activation independently of its effect on angiotensin II.

  3. A Path to Planetary Protection Requirements for Human Exploration: A Literature Review and Systems Engineering Approach

    Science.gov (United States)

    Johnson, James E.; Conley, Cassie; Siegel, Bette

    2015-01-01

    As systems, technologies, and plans for the human exploration of Mars and other destinations beyond low Earth orbit begin to coalesce, it is imperative that frequent and early consideration is given to how planetary protection practices and policy will be upheld. While the development of formal planetary protection requirements for future human space systems and operations may still be a few years from fruition, guidance to appropriately influence mission and system design will be needed soon to avoid costly design and operational changes. The path to constructing such requirements is a journey that espouses key systems engineering practices of understanding shared goals, objectives and concerns, identifying key stakeholders, and iterating a draft requirement set to gain community consensus. This paper traces through each of these practices, beginning with a literature review of nearly three decades of publications addressing planetary protection concerns with respect to human exploration. Key goals, objectives and concerns, particularly with respect to notional requirements, required studies and research, and technology development needs have been compiled and categorized to provide a current 'state of knowledge'. This information, combined with the identification of key stakeholders in upholding planetary protection concerns for human missions, has yielded a draft requirement set that might feed future iteration among space system designers, exploration scientists, and the mission operations community. Combining the information collected with a proposed forward path will hopefully yield a mutually agreeable set of timely, verifiable, and practical requirements for human space exploration that will uphold international commitment to planetary protection.

  4. The Arab activity in uranium exploration and recovery: pt. 2

    International Nuclear Information System (INIS)

    Banany, Mohamad; Lababidi, M.M.

    1985-01-01

    This is the second part of a paper given during the third Arab energy conference held in Algeria, 4 - 9 May, 1985. Information concerning uranium resources and exploration in some Arab Countries such as Algeria, Morocco, Somalia, Saudi Arabia, Sudan, and Lybia is presented. In addition to that, uranium content in phosphate rocks in the world and specially in Arab Countries is discussed. 5 refs., 4 figs., 1 tab

  5. MotionExplorer: exploratory search in human motion capture data based on hierarchical aggregation.

    Science.gov (United States)

    Bernard, Jürgen; Wilhelm, Nils; Krüger, Björn; May, Thorsten; Schreck, Tobias; Kohlhammer, Jörn

    2013-12-01

    We present MotionExplorer, an exploratory search and analysis system for sequences of human motion in large motion capture data collections. This special type of multivariate time series data is relevant in many research fields including medicine, sports and animation. Key tasks in working with motion data include analysis of motion states and transitions, and synthesis of motion vectors by interpolation and combination. In the practice of research and application of human motion data, challenges exist in providing visual summaries and drill-down functionality for handling large motion data collections. We find that this domain can benefit from appropriate visual retrieval and analysis support to handle these tasks in presence of large motion data. To address this need, we developed MotionExplorer together with domain experts as an exploratory search system based on interactive aggregation and visualization of motion states as a basis for data navigation, exploration, and search. Based on an overview-first type visualization, users are able to search for interesting sub-sequences of motion based on a query-by-example metaphor, and explore search results by details on demand. We developed MotionExplorer in close collaboration with the targeted users who are researchers working on human motion synthesis and analysis, including a summative field study. Additionally, we conducted a laboratory design study to substantially improve MotionExplorer towards an intuitive, usable and robust design. MotionExplorer enables the search in human motion capture data with only a few mouse clicks. The researchers unanimously confirm that the system can efficiently support their work.

  6. Transgenic mice expressing constitutive active MAPKAPK5 display gender-dependent differences in exploration and activity

    Directory of Open Access Journals (Sweden)

    Moens Ugo

    2007-11-01

    Full Text Available Abstract Background The mitogen-activated protein kinases, MAPKs for short, constitute cascades of signalling pathways involved in the regulation of several cellular processes that include cell proliferation, differentiation and motility. They also intervene in neurological processes like fear conditioning and memory. Since little remains known about the MAPK-Activated Protein Kinase, MAPKAPK5, we constructed the first MAPKAPK knockin mouse model, using a constitutive active variant of MAPKAPK5 and analyzed the resulting mice for changes in anxiety-related behaviour. Methods We performed primary SHIRPA observations during background breeding into the C57BL/6 background and assessed the behaviour of the background-bred animals on the elevated plus maze and in the light-dark test. Our results were analyzed using Chi-square tests and homo- and heteroscedatic T-tests. Results Female transgenic mice displayed increased amounts of head dips and open arm time on the maze, compared to littermate controls. In addition, they also explored further into the open arm on the elevated plus maze and were less active in the closed arm compared to littermate controls. Male transgenic mice displayed no differences in anxiety, but their locomotor activity increased compared to non-transgenic littermates. Conclusion Our results revealed anxiety-related traits and locomotor differences between transgenic mice expressing constitutive active MAPKAPK5 and control littermates.

  7. Physical Activity and Telomere Biology: Exploring the Link with Aging-Related Disease Prevention

    Directory of Open Access Journals (Sweden)

    Andrew T. Ludlow

    2011-01-01

    Full Text Available Physical activity is associated with reduced risk of several age-related diseases as well as with increased longevity in both rodents and humans. Though these associations are well established, evidence of the molecular and cellular factors associated with reduced disease risk and increased longevity resulting from physical activity is sparse. A long-standing hypothesis of aging is the telomere hypothesis: as a cell divides, telomeres shorten resulting eventually in replicative senescence and an aged phenotype. Several reports have recently associated telomeres and telomere-related proteins to diseases associated with physical inactivity and aging including cardiovascular disease, insulin resistance, and hypertension. Interestingly several reports have also shown that longer telomeres are associated with higher physical activity levels, indicating a potential mechanistic link between physical activity, reduced age-related disease risk, and longevity. The primary purpose of this review is to discuss the potential importance of physical activity in telomere biology in the context of inactivity- and age-related diseases. A secondary purpose is to explore potential mechanisms and important avenues for future research in the field of telomeres and diseases associated with physical inactivity and aging.

  8. Differentiating human versus non-human bone by exploring the nutrient foramen: implications for forensic anthropology.

    Science.gov (United States)

    Johnson, Vail; Beckett, Sophie; Márquez-Grant, Nicholas

    2017-11-01

    One of the roles of a forensic anthropologist is to assist medico-legal investigations in the identification of human skeletal remains. In some instances, only small fragments of bone may be present. In this study, a non-destructive novel technique is presented to distinguish between human and non-human long bones. This technique is based on the macroscopic and computed tomography (CT) analysis of nutrient foramina. The nutrient foramen of long bone diaphyses transmits the nutrient artery which provides much of the oxygen and nutrients to the bone. The nutrient foramen and its canal were analysed in six femora and humeri of human, sheep (Ovies aries) and pig (Sus scrofa) species. The location, position and direction of the nutrient foramina were measured macroscopically. The length of the canal, angle of the canal, circumference and area of the entrance of the foramen were measured from CT images. Macroscopic analysis revealed the femora nutrient foramina are more proximal, whereas humeri foramina are more distal. The human bones and sheep humerus conform to the perceived directionality, but the pig bones and sheep femur do not. Amongst the parameters measured in the CT analysis, the angle of the canal had a discriminatory power. This study shows the potential of this technique to be used independently or complementary to other methods in distinguishing between human and non-human bone in forensic anthropology.

  9. Exploiting object constancy: effects of active exploration and shape morphing on similarity judgments of novel objects.

    Science.gov (United States)

    Lee, Haemy; Wallraven, Christian

    2013-03-01

    Humans are experts at shape processing. This expertise has been learned and fine tuned by actively manipulating and perceiving thousands of objects during development. Therefore, shape processing possesses an active component and a perceptual component. Here, we investigate both components in six experiments in which participants view and/or interact with novel, parametrically defined 3D objects using a touch-screen interface. For probing shape processing, we use a similarity rating task. In Experiments 1-3, we show that active manipulation leads to a better perceptual reconstruction of the physical parameter space than judging rotating objects, or passively viewing someone else's exploration pattern. In Experiment 4, we exploit object constancy-the fact that the visual system assumes that objects do not change their identity during manipulation. We show that slow morphing of an object during active manipulation systematically biases similarity ratings-despite the participants being unaware of the morphing. Experiments 5 and 6 investigate the time course of integrating shape information by restricting the morphing to the first and second half of the trial only. Interestingly, the results indicate that participants do not seem to integrate shape information beyond 5 s of exploration time. Finally, Experiment 7 uses a secondary task that suggests that the previous results are not simply due to lack of attention during the later parts of the trial. In summary, our results demonstrate the advantage of active manipulation for shape processing and indicate a continued, perceptual integration of complex shape information within a time window of a few seconds during object interactions.

  10. Nuclear electric propulsion: A better, safer, cheaper transportation system for human exploration of Mars

    International Nuclear Information System (INIS)

    Clark, J.S.; George, J.A.; Gefert, L.P.; Doherty, M.P.; Sefcik, R.J.

    1994-03-01

    NASA has completed a preliminary mission and systems study of nuclear electric propulsion (NEP) systems for 'split-sprint' human exploration and related robotic cargo missions to Mars. This paper describes the study, the mission architecture selected, the NEP system and technology development needs, proposed development schedules, and estimated development costs. Since current administration policy makers have delayed funding for key technology development activities that could make Mars exploration missions a reality in the near future, NASA will have time to evaluate various alternate mission options, and it appears prudent to ensure that Mars mission plans focus on astronaut and mission safety, while reducing costs to acceptable levels. The split-sprint nuclear electric propulsion system offers trip times comparable to nuclear thermal propulsion (NTP) systems, while providing mission abort opportunities that are not possible with 'reference' mission architectures. Thus, NEP systems offer short transit times for the astronauts, reducing the exposure of the crew to intergalactic cosmic radiation. The high specific impulse of the NEP system, which leads to very low propellant requirements, results in significantly lower 'initial mass in low earth orbit' (IMLEO). Launch vehicle packaging studies show that the NEP system can be launched, assembled, and deployed, with about one less 240-metric-ton heavy lift launch vehicle (HLLV) per mission opportunity - a very Technology development cost of the nuclear reactor for an NEP system would be shared with the proposed nuclear surface power systems, since nuclear systems will be required to provide substantial electrical power on the surface of Mars. The NEP development project plan proposed includes evolutionary technology development for nuclear electric propulsion systems that expands upon SP-100 (Space Power - 100 kw(e)) technology that has been developed for lunar and Mars surface nuclear power

  11. 'Adventurous' judgments
    A comparative exploration into human rights as a moral-political force in judicial law development

    Directory of Open Access Journals (Sweden)

    Bas de Gaay Fortman

    2006-12-01

    Full Text Available This article looks at the development of law by the judiciary in the sense of judgments taking the law beyond the point of what was hitherto regarded as ius positivum. Its main perspective, however, is not the creation of law by the courts as such, but rather the ways and means in which the human rights idea has encouraged judges to deliver decisions that imply an overturning of 'settled' law. In the comparative exploration of 'adventurous' judgments that we shall embark on, our focus will be on the political morality of human rights as a driving force in judicial activism. It is assumed, in other words, that where the judiciary is 'active', human rights may play a part as general principles of law as distinct from rules already incorporated in positive law. Notably then, human rights in this way affect positive law in a manner other than through processes of international, regional and national standard setting connected with the establishment of new supervisory institutions and mechanisms. For this reason, the article does not so much consider typical human rights cases; instead the focus is on major decisions by national courts that were not in the first place regarded as human rights cases at all. In this endeavour, the article aims to be no more than an initial comparative exploration, intended to illustrate a function of human rights that is not normally highlighted, namely its function as an inspirational force towards 'adventurous' judgments. Yet, the judicial potential illustrated here is of great significance, as it may lead to law development inspired by the two principal pillars underpinning the international quest for the realization of human rights: universality and human dignity. After reviewing a variety of characteristic cases from such diverse legal backgrounds as the United Kingdom, the Netherlands, the United States of America, India, South Africa and Nigeria, some conclusions are drawn as to the ways in which human rights

  12. Exploring the Strategic Role of Human Resource Development in Organizational Crisis Management

    Science.gov (United States)

    Wang, Jia; Hutchins, Holly M.; Garavan, Thomas N.

    2009-01-01

    Crisis management has been a largely overlooked territory in human resource development (HRD) despite the increasingly recognized impact of organizational crises on the individual and organizational performance. This article explores the strategic role of HRD in the context of organizational crisis management using Garavan's strategic HRD model as…

  13. Guides to Sustainable Connections? Exploring Human-Nature Relationships among Wilderness Travel Leaders

    Science.gov (United States)

    Grimwood, Bryan S. R.; Haberer, Alexa; Legault, Maria

    2015-01-01

    This paper explores and critically interprets the role wilderness travel may play in fostering environmental sustainability. The paper draws upon two qualitative studies that sought to understand human-nature relationships as experienced by different groups of wilderness travel leaders in Canada. According to leaders involved in the studies,…

  14. Exploring the Relationship between Human Resource Development Functions and the Mentoring Process: A Qualitative Study

    Science.gov (United States)

    Cole, Ann F.; McArdle, Geri; Clements, Kimberly D.

    2005-01-01

    Human resource development professionals are in a unique position to help organizations achieve maximum positive impact and avoid legal difficulties when implementing mentoring programs. This case study explored a formal mentoring program that was data-based and linked to HRD in order to advance the mentoring process as an effective individual and…

  15. The Hudson River Plume: Exploring Human Impact on the Coastal Environment

    Science.gov (United States)

    McDonnell, Janice; Duncan, Ravit; Lichtenwalner, C. Sage; Dunbar, Laura

    2010-01-01

    The Hudson River Watershed contains a variety of geologic, topographic, climatic, and hydrologic features and a diversity of land-use patterns--making it an ideal model for studying human impact on the coastal environment. In this article, the authors present the Hudson River Plume (HRP), a problem-based online module that explores nonpoint-source…

  16. Technology Needs of Future Space Infrastructures Supporting Human Exploration and Development of Space

    Science.gov (United States)

    Carrington, Connie; Howell, Joe

    2001-01-01

    The path to human presence beyond near-Earth will be paved by the development of infrastructure. A fundamental technology in this infrastructure is energy, which enables not only the basic function of providing shelter for man and machine, but also enables transportation, scientific endeavors, and exploration. This paper discusses the near-term needs in technology that develop the infrastructure for HEDS.

  17. Engineering planetary exploration systems : Integrating novel technologies and the human element using work domain analysis

    NARCIS (Netherlands)

    Baker, C.; Naikar, N.; Neerincx, M.

    2008-01-01

    The realisation of sustainable space exploration and utilisation requires not only the development of novel concepts and technologies, but also their successful integration. Hardware, software, and the human element must be integrated effectively to make the dream for which these technologies were

  18. Towards human exploration of space: The THESEUS review series on immunology research priorities

    DEFF Research Database (Denmark)

    Jean-Pol, Frippiat; Crucian, Brian E; de Quervain, Dominique

    2016-01-01

    to maintain immune homeostasis under such challenges. In the framework of the THESEUS project whose aim was to develop an integrated life sciences research roadmap regarding human space exploration, experts working in the field of space immunology, and related disciplines, established a questionnaire sent...

  19. Acute activation, desensitization and smoldering activation of human acetylcholine receptors.

    Directory of Open Access Journals (Sweden)

    Barbara G Campling

    Full Text Available The behavioral effects of nicotine and other nicotinic agonists are mediated by AChRs in the brain. The relative contribution of acute activation versus chronic desensitization of AChRs is unknown. Sustained "smoldering activation" occurs over a range of agonist concentrations at which activated and desensitized AChRs are present in equilibrium. We used a fluorescent dye sensitive to changes in membrane potential to examine the effects of acute activation and chronic desensitization by nicotinic AChR agonists on cell lines expressing human α4β2, α3β4 and α7 AChRs. We examined the effects of acute and prolonged application of nicotine and the partial agonists varenicline, cytisine and sazetidine-A on these AChRs. The range of concentrations over which nicotine causes smoldering activation of α4β2 AChRs was centered at 0.13 µM, a level found in smokers. However, nicotine produced smoldering activation of α3β4 and α7 AChRs at concentrations well above levels found in smokers. The α4β2 expressing cell line contains a mixture of two stoichiometries, namely (α4β22β2 and (α4β22α4. The (α4β22β2 stoichiometry is more sensitive to activation by nicotine. Sazetidine-A activates and desensitizes only this stoichiometry. Varenicline, cytisine and sazetidine-A were partial agonists on this mixture of α4β2 AChRs, but full agonists on α3β4 and α7 AChRs. It has been reported that cytisine and varenicline are most efficacious on the (α4β22α4 stoichiometry. In this study, we distinguish the dual effects of activation and desensitization of AChRs by these nicotinic agonists and define the range of concentrations over which smoldering activation can be sustained.

  20. Physical Human Activity Recognition Using Wearable Sensors

    Directory of Open Access Journals (Sweden)

    Ferhat Attal

    2015-12-01

    Full Text Available This paper presents a review of different classification techniques used to recognize human activities from wearable inertial sensor data. Three inertial sensor units were used in this study and were worn by healthy subjects at key points of upper/lower body limbs (chest, right thigh and left ankle. Three main steps describe the activity recognition process: sensors’ placement, data pre-processing and data classification. Four supervised classification techniques namely, k-Nearest Neighbor (k-NN, Support Vector Machines (SVM, Gaussian Mixture Models (GMM, and Random Forest (RF as well as three unsupervised classification techniques namely, k-Means, Gaussian mixture models (GMM and Hidden Markov Model (HMM, are compared in terms of correct classification rate, F-measure, recall, precision, and specificity. Raw data and extracted features are used separately as inputs of each classifier. The feature selection is performed using a wrapper approach based on the RF algorithm. Based on our experiments, the results obtained show that the k-NN classifier provides the best performance compared to other supervised classification algorithms, whereas the HMM classifier is the one that gives the best results among unsupervised classification algorithms. This comparison highlights which approach gives better performance in both supervised and unsupervised contexts. It should be noted that the obtained results are limited to the context of this study, which concerns the classification of the main daily living human activities using three wearable accelerometers placed at the chest, right shank and left ankle of the subject.

  1. Physical Human Activity Recognition Using Wearable Sensors.

    Science.gov (United States)

    Attal, Ferhat; Mohammed, Samer; Dedabrishvili, Mariam; Chamroukhi, Faicel; Oukhellou, Latifa; Amirat, Yacine

    2015-12-11

    This paper presents a review of different classification techniques used to recognize human activities from wearable inertial sensor data. Three inertial sensor units were used in this study and were worn by healthy subjects at key points of upper/lower body limbs (chest, right thigh and left ankle). Three main steps describe the activity recognition process: sensors' placement, data pre-processing and data classification. Four supervised classification techniques namely, k-Nearest Neighbor (k-NN), Support Vector Machines (SVM), Gaussian Mixture Models (GMM), and Random Forest (RF) as well as three unsupervised classification techniques namely, k-Means, Gaussian mixture models (GMM) and Hidden Markov Model (HMM), are compared in terms of correct classification rate, F-measure, recall, precision, and specificity. Raw data and extracted features are used separately as inputs of each classifier. The feature selection is performed using a wrapper approach based on the RF algorithm. Based on our experiments, the results obtained show that the k-NN classifier provides the best performance compared to other supervised classification algorithms, whereas the HMM classifier is the one that gives the best results among unsupervised classification algorithms. This comparison highlights which approach gives better performance in both supervised and unsupervised contexts. It should be noted that the obtained results are limited to the context of this study, which concerns the classification of the main daily living human activities using three wearable accelerometers placed at the chest, right shank and left ankle of the subject.

  2. Human Exploration Mission Capabilities to the Moon, Mars, and Near Earth Asteroids Using ''Bimodal'' NTR Propulsion

    International Nuclear Information System (INIS)

    Stanley K. Borowski; Leonard A. Dudzinski; Melissa L. McGuire

    2000-01-01

    The nuclear thermal rocket (NTR) is one of the leading propulsion options for future human exploration missions because of its high specific impulse (Isp ∼ 850 to 1000 s) and attractive engine thrust-to-weight ratio (∼ 3 to 10). Because only a minuscule amount of enriched 235 U fuel is consumed in an NRT during the primary propulsion maneuvers of a typical Mars mission, engines configured both for propulsive thrust and modest power generation (referred to as 'bimodal' operation) provide the basis for a robust, power-rich stage with efficient propulsive capture capability at the moon and near-earth asteroids (NEAs), where aerobraking cannot be utilized. A family of modular bimodal NTR (BNTR) space transfer vehicles utilize a common core stage powered by three ∼15-klb f engines that produce 50 kW(electric) of total electrical power for crew life support, high data rate communications with Earth, and an active refrigeration system for long-term, zero-boiloff liquid hydrogen (LH 2 ) storage. This paper describes details of BNTR engines and designs of vehicles using them for various missions

  3. Exploring cellular memory molecules marking competent and active transcriptions

    Directory of Open Access Journals (Sweden)

    Liu De-Pei

    2007-05-01

    Full Text Available Abstract Background Development in higher eukaryotes involves programmed gene expression. Cell type-specific gene expression is established during this process and is inherited in succeeding cell cycles. Higher eukaryotes have evolved elegant mechanisms by which committed gene-expression states are transmitted through numerous cell divisions. Previous studies have shown that both DNase I-sensitive sites and the basal transcription factor TFIID remain on silenced mitotic chromosomes, suggesting that certain trans-factors might act as bookmarks, maintaining the information and transmitting it to the next generation. Results We used the mouse globin gene clusters as a model system to examine the retention of active information on M-phase chromosomes and its contribution to the persistence of transcriptional competence of these gene clusters in murine erythroleukemia cells. In cells arrested in mitosis, the erythroid-specific activator NF-E2p45 remained associated with its binding sites on the globin gene loci, while the other major erythroid factor, GATA-1, was removed from chromosome. Moreover, despite mitotic chromatin condensation, the distant regulatory regions and promoters of transcriptionally competent globin gene loci are marked by a preserved histone code consisting in active histone modifications such as H3 acetylation, H3-K4 dimethylation and K79 dimethylation. Further analysis showed that other active genes are also locally marked by the preserved active histone code throughout mitotic inactivation of transcription. Conclusion Our results imply that certain kinds of specific protein factors and active histone modifications function as cellular memory markers for both competent and active genes during mitosis, and serve as a reactivated core for the resumption of transcription when the cells exit mitosis.

  4. Affordable Exploration of Mars: Recommendations from a Community Workshop on Sustainable Initial Human Missions

    Science.gov (United States)

    Thronson, Harley; Carberry, Chris; Cassady, R. J.; Cooke, Doug; Hopkins, Joshua; Perino, Maria A.; Kirkpatrick, Jim; Raftery, Michael; Westenberg, Artemis; Zucker, Richard

    2013-01-01

    There is a growing consensus that within two decades initial human missions to Mars are affordable under plausible budget assumptions and with sustained international participation. In response to this idea, a distinguished group of experts from the Mars exploration stakeholder communities attended the "Affording Mars" workshop at George Washington University in December, 2013. Participants reviewed and discussed scenarios for affordable and sustainable human and robotic exploration of Mars, the role of the International Space Station over the coming decade as the essential early step toward humans to Mars, possible "bridge" missions in the 2020s, key capabilities required for affordable initial missions, international partnerships, and a usable definition of affordability and sustainability. We report here the findings, observations, and recommendations that were agreed to at that workshop.

  5. The Function of the Novel Mechanical Activated Ion Channel Piezo1 in the Human Osteosarcoma Cells

    OpenAIRE

    Jiang, Long; Zhao, Yi-ding; Chen, Wei-xiang

    2017-01-01

    Background The Piezo1 protein ion channel is a novel mechanical activated ion channel which is related to mechanical signal transduction. However, the function of the mechanically activated ion channel Piezo1 had not been explored. In this study, we explored the function of the Piezo1 ion channel in human osteosarcoma (OS) cells related to apoptosis, invasion, and the cell proliferation. Material/Methods Reverse transcription polymerase chain reaction (RT-PCR) and western-blotting were used t...

  6. The origins of human parasites: Exploring the evidence for endoparasitism throughout human evolution.

    Science.gov (United States)

    Mitchell, Piers D

    2013-09-01

    It is important to determine the origins of human parasites if we are to understand the health of past populations and the effects of parasitism upon human evolution. It also helps us to understand emerging infectious diseases and the modern clinical epidemiology of parasites. This study aims to distinguish those heirloom parasites that have infected humans and their ancestors throughout their evolution in Africa from those recent souvenir species to which humans have only become exposed following contact with animals during their migration across the globe. Ten such heirloom parasites are proposed, which appear to have been spread across the globe. Six further heirlooms are noted to have limited spread due to the constraints of their life cycle. Twelve souvenir parasites of humans are described, along with their animal reservoirs. While the origins of 28 species of endoparasite have been determined, many more species require further assessment once a more systematic analysis of ancient parasites in other regions of Africa has been undertaken. Copyright © 2013 Elsevier Inc. All rights reserved.

  7. Effects of Active Exploration and Passive Observation on Spatial Learning in a CAVE

    OpenAIRE

    Melanson, Brian; Kelso, John; Bowman, Doug A.

    2002-01-01

    This experiment was a modification of Paul N. Wilson's 1999 study entitled "Active Exploration of a Virtual Environment Does Not Promote Orientation or Memory for Objects." It was hoped that changing the immersion level from a standard desktop monitor to a more immersive CAVE environment would change the results of this experiment. All subjects explored a three-dimensional virtual environment in a CAVE. Active subjects were given controls to choose their own path and explore th...

  8. Exploring Preferences of Mentoring Activities among Generational Groups of Registered Nurses in Florida

    Science.gov (United States)

    Posey-Goodwin, Patricia Ann

    2013-01-01

    The purpose of this study was to explore differences in perceptions of mentoring activities from four generations of registered nurses in Florida, using the Alleman Mentoring Activities Questionnaire ® (AMAQ ®). Statistical procedures of analysis of variance (ANOVA) were employed to explore differences among 65 registered nurses in Florida from…

  9. Frontiers of Life Sciences: The Human Exploration of the Moon and Mars

    Science.gov (United States)

    North, Regina M.; Pellis, Neal R.

    2005-01-01

    The rapid development of the productive processes after World War II extended human settlements into new ecological niches. Advances in Life Sciences played a decisive role supporting the establishment of human presence in areas of the planet where human life could have not existed otherwise. The evolution of life support systems, and the fabrication of new materials and technologies has enabled humans to inhabit Polar Regions, ocean surfaces and depths; and to leave Earth and occupy Low Earth Orbit. By the end of the 20 th Century, stations in the Antarctic and Arctic, off shore oil platforms, submarines, and space stations had become the ultimate demonstration of human ability to engineer habitats at Earth extreme environments and outer space. As we enter the 21st Century, the next development of human settlements will occur through the exploration of the Moon, Mars, and beyond. The major risks of space exploration derive from long exposure of humans and other life systems to radiation, microgravity, isolation and confinement, dependence on artificial life support systems, and unknown effects (e.g., altered magnetic fields, ultrahigh vacuum on bacteria, fungi, etc.). Countermeasures will require a complete characterization of human and other biological systems adaptation processes. To sustain life in transit and on the surface of the Moon and Mars will require a balance of spacecraft, cargo, astronaut crews, and the use of in situ resources. Limitations on the number of crewmembers, payloads, and the barrenness of the terrain require a novel design for the capabilities needed in transit and at exploration outpost sites. The planned destinations have resources that may be accessed to produce materials, food, shelter, power, and to provide an environment compatible with successful occupation of longterm exploration sites. Once more, the advancements of Life Sciences will be essential for the design of interplanetary voyages and planetary surface operations. This

  10. Toward a dynamic perspective on explorative and exploitative innovation activities: a longitudinal study of innovation in the wind blade industry

    NARCIS (Netherlands)

    de Visser, Matthias

    2010-01-01

    Innovation requires a combination of explorative and exploitative innovation activities. Previous studies have provided valuable insights in the antecedents of investing in explorative and exploitative activities, the structural governance of exploration and exploitation and the performance

  11. Toward a dynamic perspective on explorative and exploitative innovation activities: A longitudinal study of innovation in the wind blade industry

    NARCIS (Netherlands)

    de Visser, Matthias; Faems, D.L.M.

    2010-01-01

    Innovation requires a combination of explorative and exploitative innovation activities. Previous studies have provided valuable insights in the antecedents of investing in explorative and exploitative activities, the structural governance of exploration and exploitation and the performance

  12. Exploring Patient Activation in the Clinic: Measurement from Three Perspectives

    Science.gov (United States)

    Ledford, Christy J. W.; Ledford, Christopher C.; Childress, Marc A.

    2013-01-01

    Objective. To further conceptualize and operationalize patient activation (PA), using measures from patient, physician, and researcher perspectives. Data Source/Study Setting. Multimethod observation in 2010 within a family medicine clinic. Study Design. Part of an intervention with 130 patients with type 2 diabetes, this observational study…

  13. ShuttleKickers : exploring social persuasions to encourage physical activities

    NARCIS (Netherlands)

    Ren, X.; Lu, Y.; Brombacher, A.C.; Bekker, M.M.

    In the HCI domain, many researches have been carried out on how to apply Persuasive Technology (PT) to stimulate a more active lifestyle. Regarding collectivist cultures, social influence has been considered as one of the most impactful factors among others in PT. Within one societal context,

  14. Active exploration and keypoint clustering for object recognition

    NARCIS (Netherlands)

    Kootstra, G.W.; Ypma, J; de Boer, B.

    2008-01-01

    Object recognition is a challenging problem for artificial systems. This is especially true for objects that are placed in cluttered and uncontrolled environments. To challenge this problem, we discuss an active approach to object recognition. Instead of passively observing objects, we use a robot

  15. Exploring Uncertainty Perception as a Driver of Design Activity

    DEFF Research Database (Denmark)

    Cash, Philip; Kreye, Melanie

    2018-01-01

    , and representation action. We bring together prior works on uncertainty perception in the design and management literatures to derive three contributions. First, we describe how uncertainty perception is associated with activity progression, linking all three core actions. Second, we identify characteristic patterns...

  16. Does solar activity affect human happiness?

    Science.gov (United States)

    Kristoufek, Ladislav

    2018-03-01

    We investigate the direct influence of solar activity (represented by sunspot numbers) on human happiness (represented by the Twitter-based Happiness Index). We construct four models controlling for various statistical and dynamic effects of the analyzed series. The final model gives promising results. First, there is a statistically significant negative influence of solar activity on happiness which holds even after controlling for the other factors. Second, the final model, which is still rather simple, explains around 75% of variance of the Happiness Index. Third, our control variables contribute significantly as well: happiness is higher in no sunspots days, happiness is strongly persistent, there are strong intra-week cycles and happiness peaks during holidays. Our results strongly contribute to the topical literature and they provide evidence of unique utility of the online data.

  17. Robotic Reconnaissance Missions to Small Bodies and Their Potential Contributions to Human Exploration

    Science.gov (United States)

    Abell, P. A.; Rivkin, A. S.

    2015-01-01

    Introduction: Robotic reconnaissance missions to small bodies will directly address aspects of NASA's Asteroid Initiative and will contribute to future human exploration. The NASA Asteroid Initiative is comprised of two major components: the Grand Challenge and the Asteroid Mission. The first component, the Grand Challenge, focuses on protecting Earth's population from asteroid impacts by detecting potentially hazardous objects with enough warning time to either prevent them from impacting the planet, or to implement civil defense procedures. The Asteroid Mission involves sending astronauts to study and sample a near- Earth asteroid (NEA) prior to conducting exploration missions of the Martian system, which includes Phobos and Deimos. The science and technical data obtained from robotic precursor missions that investigate the surface and interior physical characteristics of an object will help identify the pertinent physical properties that will maximize operational efficiency and reduce mission risk for both robotic assets and crew operating in close proximity to, or at the surface of, a small body. These data will help fill crucial strategic knowledge gaps (SKGs) concerning asteroid physical characteristics that are relevant for human exploration considerations at similar small body destinations. Small Body Strategic Knowledge Gaps: For the past several years NASA has been interested in identifying the key SKGs related to future human destinations. These SKGs highlight the various unknowns and/or data gaps of targets that the science and engineering communities would like to have filled in prior to committing crews to explore the Solar System. An action team from the Small Bodies Assessment Group (SBAG) was formed specifically to identify the small body SKGs under the direction of the Human Exploration and Operations Missions Directorate (HEOMD), given NASA's recent interest in NEAs and the Martian moons as potential human destinations [1]. The action team

  18. Statistics and risk philosophy in human activities

    International Nuclear Information System (INIS)

    Failla, L.

    1983-01-01

    Two leading interpretations of the use of statistics exist, the first one considering statistics as a physical law regulating the phenomena studied, and the other considering statistics as a method allowing to achieve exhaustive knowledge of the phenomena. The Author chooses the second theory, applies this concept of statistics to the risk involved in human activities and discusses the different kinds of risk in this field. The Author distinguishes between the risk that can be eliminated or at least reduced, and the risk inherent in the activity itself, that can never be completely eliminated -unless the activity is suppressed-; yet, also this kind of risk can be kept under control. Furthermore, she distinguishes between risks that can or cannot be foreseen. The Author supports the theory according to which the risk foreseen must be prevented through up-to-date techniques: this should be done coherently with the aim of the activity but independently of the economic cost. The theory considering risk probability as a physical law is mainly based on events happened in the past: it uses the occurrence probability as a law. This theory accepts the statistical risk and estimates its costs, including the ''human cost''. The Author examines the different statistical possibilities to study this specific phenomenon: so, the possibility to avoid the risks may arise along with -last but not least- the opportunity to eliminate or reduce the damage connected. On the contrary, statistics used as a physical law implies the acceptable of a given amount of risk compared with the cost of improving the technical conditions required to eliminate damages. In the end, a practical example of this theory is described

  19. Robust Indoor Human Activity Recognition Using Wireless Signals.

    Science.gov (United States)

    Wang, Yi; Jiang, Xinli; Cao, Rongyu; Wang, Xiyang

    2015-07-15

    Wireless signals-based activity detection and recognition technology may be complementary to the existing vision-based methods, especially under the circumstance of occlusions, viewpoint change, complex background, lighting condition change, and so on. This paper explores the properties of the channel state information (CSI) of Wi-Fi signals, and presents a robust indoor daily human activity recognition framework with only one pair of transmission points (TP) and access points (AP). First of all, some indoor human actions are selected as primitive actions forming a training set. Then, an online filtering method is designed to make actions' CSI curves smooth and allow them to contain enough pattern information. Each primitive action pattern can be segmented from the outliers of its multi-input multi-output (MIMO) signals by a proposed segmentation method. Lastly, in online activities recognition, by selecting proper features and Support Vector Machine (SVM) based multi-classification, activities constituted by primitive actions can be recognized insensitive to the locations, orientations, and speeds.

  20. Robust Indoor Human Activity Recognition Using Wireless Signals

    Directory of Open Access Journals (Sweden)

    Yi Wang

    2015-07-01

    Full Text Available Wireless signals–based activity detection and recognition technology may be complementary to the existing vision-based methods, especially under the circumstance of occlusions, viewpoint change, complex background, lighting condition change, and so on. This paper explores the properties of the channel state information (CSI of Wi-Fi signals, and presents a robust indoor daily human activity recognition framework with only one pair of transmission points (TP and access points (AP. First of all, some indoor human actions are selected as primitive actions forming a training set. Then, an online filtering method is designed to make actions’ CSI curves smooth and allow them to contain enough pattern information. Each primitive action pattern can be segmented from the outliers of its multi-input multi-output (MIMO signals by a proposed segmentation method. Lastly, in online activities recognition, by selecting proper features and Support Vector Machine (SVM based multi-classification, activities constituted by primitive actions can be recognized insensitive to the locations, orientations, and speeds.

  1. Novel innate cancer killing activity in humans

    Directory of Open Access Journals (Sweden)

    Lovato James

    2011-08-01

    Full Text Available Abstract Background In this study, we pilot tested an in vitro assay of cancer killing activity (CKA in circulating leukocytes of 22 cancer cases and 25 healthy controls. Methods Using a human cervical cancer cell line, HeLa, as target cells, we compared the CKA in circulating leukocytes, as effector cells, of cancer cases and controls. The CKA was normalized as percentages of total target cells during selected periods of incubation time and at selected effector/target cell ratios in comparison to no-effector-cell controls. Results Our results showed that CKA similar to that of our previous study of SR/CR mice was present in human circulating leukocytes but at profoundly different levels in individuals. Overall, males have a significantly higher CKA than females. The CKA levels in cancer cases were lower than that in healthy controls (mean ± SD: 36.97 ± 21.39 vs. 46.28 ± 27.22. Below-median CKA was significantly associated with case status (odds ratio = 4.36; 95% Confidence Interval = 1.06, 17.88 after adjustment of gender and race. Conclusions In freshly isolated human leukocytes, we were able to detect an apparent CKA in a similar manner to that of cancer-resistant SR/CR mice. The finding of CKA at lower levels in cancer patients suggests the possibility that it may be of a consequence of genetic, physiological, or pathological conditions, pending future studies with larger sample size.

  2. The spatial structure of transnational human activity.

    Science.gov (United States)

    Deutschmann, Emanuel

    2016-09-01

    Starting from conflictive predictions of hitherto disconnected debates in the natural and social sciences, this article examines the spatial structure of transnational human activity (THA) worldwide (a) across eight types of mobility and communication and (b) in its development over time. It is shown that the spatial structure of THA is similar to that of animal displacements and local-scale human motion in that it can be approximated by Lévy flights with heavy tails that obey power laws. Scaling exponent and power-law fit differ by type of THA, being highest in refuge-seeking and tourism and lowest in student exchange. Variance in the availability of resources and opportunities for satisfying associated needs appears to explain these differences. Over time (1960-2010), the Lévy-flight pattern remains intact and remarkably stable, contradicting the popular notion that socio-technological trends lead to a "death of distance." Humans have not become more "global" over time, they rather became more mobile in general, i.e. they move and communicate more at all distances. Hence, it would be more adequate to speak of "mobilization" than of "globalization." Longitudinal change occurs only in some types of THA and predominantly at short distances, indicating regional rather than global shifts. Copyright © 2016 Elsevier Inc. All rights reserved.

  3. Performance of humans vs. exploration algorithms on the Tower of London Test.

    Directory of Open Access Journals (Sweden)

    Eric Fimbel

    Full Text Available The Tower of London Test (TOL used to assess executive functions was inspired in Artificial Intelligence tasks used to test problem-solving algorithms. In this study, we compare the performance of humans and of exploration algorithms. Instead of absolute execution times, we focus on how the execution time varies with the tasks and/or the number of moves. This approach used in Algorithmic Complexity provides a fair comparison between humans and computers, although humans are several orders of magnitude slower. On easy tasks (1 to 5 moves, healthy elderly persons performed like exploration algorithms using bounded memory resources, i.e., the execution time grew exponentially with the number of moves. This result was replicated with a group of healthy young participants. However, for difficult tasks (5 to 8 moves the execution time of young participants did not increase significantly, whereas for exploration algorithms, the execution time keeps on increasing exponentially. A pre-and post-test control task showed a 25% improvement of visuo-motor skills but this was insufficient to explain this result. The findings suggest that naive participants used systematic exploration to solve the problem but under the effect of practice, they developed markedly more efficient strategies using the information acquired during the test.

  4. Exploring the efficiency potential for an active magnetic regenerator

    DEFF Research Database (Denmark)

    Eriksen, Dan; Engelbrecht, Kurt; Haffenden Bahl, Christian Robert

    2016-01-01

    A novel rotary state of the art active magnetic regenerator refrigeration prototype was used in an experimental investigation with special focus on efficiency. Based on an applied cooling load, measured shaft power, and pumping power applied to the active magnetic regenerator, a maximum second-la...... and replacing the packed spheres with a theoretical parallel plate regenerator. Furthermore, significant potential efficiency improvements through optimized regenerator geometries are estimated and discussed......., especially for the pressure drop, significant improvements can be made to the machine. However, a large part of the losses may be attributed to regenerator irreversibilities. Considering these unchanged, an estimated upper limit to the second-law efficiency of 30% is given by eliminating parasitic losses...

  5. Exploration of the anti-enterovirus activity of a series of pleconaril/pirodavir-like compounds.

    Science.gov (United States)

    Bernard, Angela; Lacroix, Céline; Cabiddu, Maria G; Neyts, Johan; Leyssen, Pieter; Pompei, Raffaello

    2015-04-01

    The Enterovirus genus of the Picornaviridae is represented by several viral pathogens that are associated with human disease, namely Poliovirus 1, Enterovirus 71 and Rhinoviruses. Enterovirus 71 has been associated with encephalitis, while Rhinoviruses are a major cause of asthma exacerbations and chronic obstructive pulmonary disease. Based on the structure of both pleconaril and pirodavir, we previously synthesized some original compounds as potential inhibitors of Rhinovirus replication. These compounds were explored for in vitro antiviral potential on other human pathogenic Enteroviruses, namely Enterovirus 71 on rhabdo-myosarcoma cells, Coxsackievirus B3 on Vero cells, Poliovirus 1 and Echovirus 11 on BGM cells. Activity was confirmed for compound against Rhinovirus 14. Furthermore, few compounds showed a cell-protective effect on Enterovirus 71, presented a marked improvement as compared to the reference drug pleconaril for inhibitory activity on both Enterovirus 71 and Poliovirus 1. The most striking observation was the clear cell protective effect for the set of analogues in a virus-cell-based assay for Echovirus 11 with an effective concentration (EC50) as low as 0.3 µM (Selectivity index or SI = 483), and selectivity indexes greater than 857 (EC50 = 0.6 µM) and 1524 (EC50 = 0.33 µM). Some of the evaluated compounds showed potent and selective antiviral activity against several enterovirus species, such as Enterovirus 71 (EV-A), Echovirus 11 (EV-B), and Poliovirus 1 (EV-C). This could be used as a starting point for the development of other pleconaril/pirodavir-like enterovirus inhibitors with broad-spectrum activity and improved effects as compared to the reference drugs. © The Author(s) 2015.

  6. Prevalence of Telomerase Activity in Human Cancer

    Directory of Open Access Journals (Sweden)

    Chi-Hau Chen

    2011-05-01

    Full Text Available Telomerase activity has been measured in a wide variety of cancerous and non-cancerous tissue types, and the vast majority of clinical studies have shown a direct correlation between it and the presence of cancerous cells. Telomerase plays a key role in cellular immortality and tumorigenesis. Telomerase is activated in 80–90% of human carcinomas, but not in normal somatic cells, therefore, its detection holds promise as a diagnostic marker for cancer. Measurable levels of telomerase have been detected in malignant cells from various samples: tissue from gestational trophoblastic neoplasms; squamous carcinoma cells from oral rinses; lung carcinoma cells from bronchial washings; colorectal carcinoma cells from colonic luminal washings; bladder carcinoma cells from urine or bladder washings; and breast carcinoma or thyroid cancer cells from fine needle aspirations. Such clinical tests for telomerase can be useful as non-invasive and cost-effective methods for early detection and monitoring of cancer. In addition, telomerase activity has been shown to correlate with poor clinical outcome in late-stage diseases such as non-small cell lung cancer, colorectal cancer, and soft tissue sarcomas. In such cases, testing for telomerase activity can be used to identify patients with a poor prognosis and to select those who might benefit from adjuvant treatment. Our review of the latest medical advances in this field reveals that telomerase holds great promise as a biomarker for early cancer detection and monitoring, and has considerable potential as the basis for developing new anticancer therapies.

  7. The Asteroid Impact and Deflection Assessment Mission and its Potential Contributions to Human Exploration of Asteroids

    Science.gov (United States)

    Abell, Paul A.; Rivkin, Andy S.

    2014-01-01

    The joint ESA and NASA Asteroid Impact and Deflection Assessment (AIDA) mission will directly address aspects of NASA's Asteroid Initiative and will contribute to future human exploration. The NASA Asteroid Initiative is comprised of two major components: the Grand Challenge and the Asteroid Mission. The first component, the Grand Challenge, focuses on protecting Earth's population from asteroid impacts by detecting potentially hazardous objects with enough warning time to either prevent them from impacting the planet, or to implement civil defense procedures. The Asteroid Mission, involves sending astronauts to study and sample a near-Earth asteroid (NEA) prior to conducting exploration missions of the Martian system, which includes Phobos and Deimos. AIDA's primary objective is to demonstrate a kinetic impact deflection and characterize the binary NEA Didymos. The science and technical data obtained from AIDA will aid in the planning of future human exploration missions to NEAs and other small bodies. The dual robotic missions of AIDA, ESA's Asteroid Impact Monitor (AIM) and NASA's Double Asteroid Redirection Test (DART), will provide a great deal of technical and engineering data on spacecraft operations for future human space exploration while conducting in-depth scientific examinations of the binary target Didymos both prior to and after the kinetic impact demonstration. The knowledge gained from this mission will help identify asteroidal physical properties in order to maximize operational efficiency and reduce mission risk for future small body missions. The AIDA data will help fill crucial strategic knowledge gaps concerning asteroid physical characteristics that are relevant for human exploration considerations at similar small body destinations.

  8. Multinational Exploration of Acquired R&D Activities

    DEFF Research Database (Denmark)

    Gammelgaard, Jens

    2004-01-01

    R&D. This paper establishes the connection between amultinational corporation that follows a capability-motivated acquisition strategy and theR&D role new subsidiaries should play in order for the acquired resources to be utilizedcorporation-wide. Statistical findings reveal the need to follow......This paper presents the results of a survey of 54 Danish multinational corporations that haveacquired activities abroad. The role of the acquired R&D units was the focus of the survey,particularly with respect to the schism between basic and applied R&D, and the schismbetween autonomous and network...

  9. Exploring value creation from corporate-foresight activities

    DEFF Research Database (Denmark)

    Rohrbeck, René

    2012-01-01

    This paper looks at value creation from corporate futures research. Through a literature review, potential value creation is identified. This serves as guidance for an empirical investigation in which value creation is observed and linked to methods and practices. Using data from 20 case studies......, three examples of value creation are discussed in detail. In addition, cross-case analysis allowed me to identify four success criteria for corporate foresight activities: (1) foresighters committed to creating value, (2) participation of internal stakeholders, (3) analysis that follows a systemic logic...

  10. Humanities data in R exploring networks, geospatial data, images, and text

    CERN Document Server

    Arnold, Taylor

    2015-01-01

    This pioneering book teaches readers to use R within four core analytical areas applicable to the Humanities: networks, text, geospatial data, and images. This book is also designed to be a bridge: between quantitative and qualitative methods, individual and collaborative work, and the humanities and social scientists. Exploring Humanities Data Types with R does not presuppose background programming experience. Early chapters take readers from R set-up to exploratory data analysis (continuous and categorical data, multivariate analysis, and advanced graphics with emphasis on aesthetics and facility). Everything is hands-on: networks are explained using U.S. Supreme Court opinions, and low-level NLP methods are applied to short stories by Sir Arthur Conan Doyle. The book’s data, code, appendix with 100 basic programming exercises and solutions, and dedicated website are valuable resources for readers. The methodology will have wide application in classrooms and self-study for the humanities, but also for use...

  11. Experiment of exploration using the active-faults exploration system; Katsudanso tansa system wo mochiita chika tansa jikken

    Energy Technology Data Exchange (ETDEWEB)

    Mikada, H; Sato, H; Iwasaki, T; Hirata, N [The University of Tokyo, Tokyo (Japan). Earthquake Research Institute; Ikeda, Y [The University of Tokyo, Tokyo (Japan). Faculty of Science; Ikawa, T; Kawabe, Y; Aoki, Y [JAPEX Geoscience Institute, Tokyo (Japan)

    1996-10-01

    A system for exploration of active-faults by seismic reflection profiling method was introduced at Earthquake Research Institute, University of Tokyo. A test-run was conducted to check the performance of this system at Ranzan, Saitama Prefecture. This paper describes the confirmed performance of mini-VIB as a wide band frequency seismic source, the quality of data obtained using a digital data acquisition system, and problems for data processing of fault exploration in the future. For the test-run at Ranzan, two-dimensional exploration was conducted by the quasi-three-dimensional data acquisition method using three geophones of 8 Hz, 28 Hz, and 40 Hz, simply arranged in parallel on the measurement line. Using an active seismic vibrator, mini-VIB, data acquisition of faults in the wide band frequency was achieved, which would result in the highly accurate imaging. Operation of data acquisition and processing systems is easy, and the system can be also used as a kind of black box. The existing methods are to be used sufficiently as a tool for imaging of faults. Further research for accumulating experience may become necessary toward the extension of the system expected in the future. 5 refs., 6 figs.

  12. Exploring Size.

    Science.gov (United States)

    Brand, Judith, Ed.

    1995-01-01

    "Exploring" is a magazine of science, art, and human perception that communicates ideas museum exhibits cannot demonstrate easily by using experiments and activities for the classroom. This issue concentrates on size, examining it from a variety of viewpoints. The focus allows students to investigate and discuss interconnections among…

  13. Enzymatic characterization of a human acyltransferase activity.

    Directory of Open Access Journals (Sweden)

    Akihiko Ozawa

    Full Text Available Non-histone protein acylation is increasingly recognized as an important posttranslational modification, but little is known as to the biochemical properties of protein serine acylating enzymes.We here report that we have identified a metal-stimulated serine octanoyltransferase activity in microsomes from human erythroleukemic (HEL cells. The HEL acylating enzyme was linear with respect to time and protein, exhibited a neutral pH optimum (stimulated by cobalt and zinc, and inhibited by chelating reagents. Hydroxylamine treatment removed most, but not all, of the attached radioactivity. A salt extract of microsomal membranes contained the major portion of enzyme activity, indicating that this acyltransferase is not an integral membrane protein. Sucrose density fractionation showed that the acyltransferase activity is concentrated in the endoplasmic reticulum. In competition experiments, the acyltransferase was well inhibited by activated forms of fatty acids containing at least eight to fourteen carbons, but not by acetyl CoA. The zinc-stimulated HEL acyltransferase did not octanoylate proenkephalin, proopiomelanocortin, His-tagged proghrelin, or proghrelin lacking the amino-terminal His-tag stub of Gly-Ala-Met. The peptides des-acyl ghrelin and ACTH were also not acylated; however, des-acyl ghrelin containing the N-terminal tripeptide Gly-Ala-Met was acylated. Mutagenesis studies indicated a requirement for serine five residues from the amino terminus, reminiscent of myristoyl transferase, but not of ghrelin acylation. However, recombinant myristoyl transferase could not recapitulate the hydroxylamine sensitivity, zinc-stimulation, nor EDTA inhibition obtained with HEL acyltransferase, properties preserved in the HEL cell enzyme purified through four sequential chromatographic steps.In conclusion, our data demonstrate the presence of a zinc-stimulated acyltransferase activity concentrated in the endoplasmic reticulum in HEL cells which is likely

  14. Sympathetic activation during early pregnancy in humans

    Science.gov (United States)

    Jarvis, Sara S; Shibata, Shigeki; Bivens, Tiffany B; Okada, Yoshiyuki; Casey, Brian M; Levine, Benjamin D; Fu, Qi

    2012-01-01

    Sympathetic activity has been reported to increase in normotensive pregnant women, and to be even greater in women with gestational hypertension and preeclampsia at term. Whether sympathetic overactivity develops early during pregnancy, remaining high throughout gestation, or whether it only occurs at term providing the substrate for hypertensive disorders is unknown. We tested the hypothesis that sympathetic activation occurs early during pregnancy in humans. Eleven healthy women (29 ± 3 (SD) years) without prior hypertensive pregnancies were tested during the mid-luteal phase (PRE) and early pregnancy (EARLY; 6.2 ± 1.2 weeks of gestation). Muscle sympathetic nerve activity (MSNA) and haemodynamics were measured supine, at 30 deg and 60 deg upright tilt for 5 min each. Blood samples were drawn for catecholamines, direct renin, and aldosterone. MSNA was significantly greater during EARLY than PRE (supine: 25 ± 8 vs. 14 ± 8 bursts min−1, 60 deg tilt: 49 ± 14 vs. 40 ± 10 bursts min−1; main effect, P < 0.05). Resting diastolic pressure trended lower (P = 0.09), heart rate was similar, total peripheral resistance decreased (2172 ± 364 vs. 2543 ± 352 dyne s cm−5; P < 0.05), sympathetic vascular transduction was blunted (0.10 ± 0.05 vs. 0.36 ± 0.47 units a.u.−1 min−1; P < 0.01), and both renin (supine: 27.9 ± 6.2 vs. 14.2 ± 8.7 pg ml−1, P < 0.01) and aldosterone (supine: 16.7 ± 14.1 vs. 7.7 ± 6.8 ng ml−1, P = 0.05) were higher during EARLY than PRE. These results suggest that sympathetic activation is a common characteristic of early pregnancy in humans despite reduced diastolic pressure and total peripheral resistance. These observations challenge conventional thinking about blood pressure regulation during pregnancy, showing marked sympathetic activation occurring within the first few weeks of conception, and may provide the substrate for pregnancy induced cardiovascular complications. PMID:22687610

  15. Ontologies and Possibilities of Human Rights: Exploring Dissensus to Facilitate Reconciliation in Post-Conflict Education Contexts

    Science.gov (United States)

    du Preez, Petro; Becker, Anne

    2016-01-01

    In light of growing critique of human rights and human rights education, this article explores ontologies of human rights, the possibilities they present for dissensus and how this could influence human rights education in post-conflict education contexts towards reconciliation. We draw on Dembour's (2010) categorisation of the different schools…

  16. Timing of nurses activities: human resources management

    Directory of Open Access Journals (Sweden)

    Hamid Hosein Poor

    2016-11-01

    Full Text Available Costs of human resources include a high percentage of hospital’s costs; therefore, determination of number of real and optimal employees needed for organizations is very important. In the meantime, the optimal organization of nurses, as the biggest human resource in health care organizations, is of great importance. The present study aimed to assess the distribution of nurses’ activities in shifts and the results of productivity in human resources management in Imam Khomeini hospital in Shirvan. The present cross-sectional study was conducted in 2016. All nurses, working in three shifts of morning, afternoon, and evening in emergency unit and general units of Imam Khomeini hospital, Shirvan, were enrolled into the study through census methods. The instrument, used in this study, was the checklist of timing activities and patients’ satisfaction from nurses. The statistical software SPSS was used for analysis. Mean age of employees in these two units/wards was 31 years and mean duration of work experience was 5.24 years, The difference was significant between the two wards. necessity of the work, especially in emergency unit, are issues that need more assessment and need to be adjusted. Given the high volume of non-care matters of nursing staff, including writing services, including completing paper records and work with HIS (Hospital Information System, which has been emphasized in several studies, new definition of service and use of artificial intelligence with high efficacy is proposed. The status of the available equipment, availability, and efficiency of digital equipment and hoteling state of wards and hospitals also play an important factor in the distribution of time of nursing care activities. Employment of nurses to perform non-nursing duties, because of the shortage of other classes or lack of their permanent presence and based on Although there were differences in standard time of direct and indirect care in emergency unit and

  17. Human activity and rest in situ.

    Science.gov (United States)

    Roenneberg, Till; Keller, Lena K; Fischer, Dorothee; Matera, Joana L; Vetter, Céline; Winnebeck, Eva C

    2015-01-01

    Our lives are structured by the daily alternation of activity and rest, of wake and sleep. Despite significant advances in circadian and sleep research, we still lack answers to many of the most fundamental questions about this conspicuous behavioral pattern. We strongly believe that investigating this pattern in entrained conditions, real-life and daily contexts-in situ-will help the field to elucidate some of these central questions. Here, we present two common approaches for in situ investigation of human activity and rest: the Munich ChronoType Questionnaire (MCTQ) and actimetry. In the first half of this chapter, we provide detailed instructions on how to use and interpret the MCTQ. In addition, we give an overview of the main insights gained with this instrument over the past 10 years, including some new findings on the interaction of light and age on sleep timing. In the second half of this chapter, we introduce the reader to the method of actimetry and share our experience in basic analysis techniques, including visualization, smoothing, and cosine model fitting of in situ recorded data. Additionally, we describe our new approach to automatically detect sleep from activity recordings. Our vision is that the broad use of such easy techniques in real-life settings combined with automated analyses will lead to the creation of large databases. The resulting power of big numbers will promote our understanding of such fundamental biological phenomena as sleep. © 2015 Elsevier Inc. All rights reserved.

  18. Exploring the role of the human resource function in the South African information technology industry

    Directory of Open Access Journals (Sweden)

    Caron Hall

    2007-01-01

    Full Text Available The Information Technology (IT industry is one that is characterised by rapid change and a heavy reliance on human skills. A study was conducted to qualitatively explore the role of the Human Resource (HR function in the South African IT industry. Semi-structured individual and focus group interviews with professionals in this function highlighted many opportunities for HR to render a more strategic role in an environment where a skills shortage and many related problem areas exist. The implications of these findings are discussed and proposals for redefining the role of HR in the specific industry are offered.

  19. Modeling and Simulation for Exploring Human-Robot Team Interaction Requirements

    Energy Technology Data Exchange (ETDEWEB)

    Dudenhoeffer, Donald Dean; Bruemmer, David Jonathon; Davis, Midge Lee

    2001-12-01

    Small-sized and micro-robots will soon be available for deployment in large-scale forces. Consequently, the ability of a human operator to coordinate and interact with largescale robotic forces is of great interest. This paper describes the ways in which modeling and simulation have been used to explore new possibilities for human-robot interaction. The paper also discusses how these explorations have fed implementation of a unified set of command and control concepts for robotic force deployment. Modeling and simulation can play a major role in fielding robot teams in actual missions. While live testing is preferred, limitations in terms of technology, cost, and time often prohibit extensive experimentation with physical multi-robot systems. Simulation provides insight, focuses efforts, eliminates large areas of the possible solution space, and increases the quality of actual testing.

  20. An Active Plasmonic to Explore on-Chip Sensing Applications

    Directory of Open Access Journals (Sweden)

    Nan-Fu Chiu

    2016-06-01

    Full Text Available We report the influence of top emission and transparent organic electroluminescence (OEL devices on the color tunability, viewing angle and enhancement light efficiency by surface plasmon grating coupled emission (SPGCE, the effects of coupled active SPPs on the metal nano-grating with organic material interface by cross-coupled into far-field space. Owing to the narrow band emission from the SPGCE, one can observe clear color changes at a certain viewing angle with different permittivities. The experimental and theoretical results showed that OEL-SPGCE at different pitch can match a linear shifting of momentum (DK of about 4.8 mm-1 per 100 nm pitch size. The color changes from -1.1 degree (water, -.07 degree (glucose 10 %, -2.5 degree (glucose 20 %, to 6 degree (glucose 40 % with the increasing permittivities. The OEL-SPGCE biosensor is proposed for the development of novel devices, which is expected to improve the capability of electroluminescent bio-plasmonic resonance measurement devices in the future.

  1. Exploring Anopheles gut bacteria for Plasmodium blocking activity

    Science.gov (United States)

    Bahia, Ana C; Dong, Yuemei; Blumberg, Benjamin J; Mlambo, Godfree; Tripathi, Abhai; BenMarzouk-Hidalgo, Omar J; Chandra, Ramesh; Dimopoulos, George

    2014-01-01

    SUMMARY Malaria parasite transmission requires the successful development of Plasmodium gametocytes into flagellated microgametes upon mosquito blood ingestion, and the subsequent fertilization of microgametes and macrogametes for the development of motile zygotes, called ookinetes, which invade and transverse the Anopheles vector mosquito midgut at around 18-36 h after blood ingestion. Within the mosquito midgut, the malaria parasite has to withstand the mosquito's innate immune response and the detrimental effect of its commensal bacterial flora. We have assessed the midgut colonization capacity of 5 gut bacterial isolates from field-derived, and 2 from laboratory colony, mosquitoes and their effect on Plasmodium development in vivo and in vitro, along with their impact on mosquito survival. Some bacterial isolates activated the mosquito's immune system, affected the mosquito's life span, and were capable of blocking Plasmodium development. We have also shown that the ability of these bacteria to inhibit the parasites is likely to involve different mechanisms and factors. A Serratia marcescens isolate was particularly efficient in colonizing the mosquitoes’ gut, compromising mosquito survival, and inhibiting both sexual- and asexual-stage Plasmodium through secreted factors, thereby rendering it a potential candidate for the development of a malaria transmission intervention strategy. PMID:24428613

  2. The Exploration of human experience in Jane Austen's Northanger Abbey

    OpenAIRE

    Mulas, Francesco Gesuino

    2005-01-01

    Jane Austen's purpose in Northanger Abbey, both in her aesthetic principles and moral intents, is to explore the human experience in its fullest sense. How do people perceive and understand themselves and each other? What are they like and how can they learn and grow? If moral problems are a question of thought rather than of action, as a consequence to ask what characters are like is also to ask what an author's conception of them should be.

  3. Exploring human papillomavirus vaccination refusal among ethnic minorities in England: A comparative qualitative study

    OpenAIRE

    Forster, Alice S.; Rockliffe, Lauren; Marlow, Laura A.V.; Bedford, Helen; McBride, Emily; Waller, Jo

    2017-01-01

    Abstract Objectives In England, uptake of human papillomavirus (HPV) vaccination to prevent HPV‐related cancer is lower among girls from ethnic minority backgrounds. We aimed to explore the factors that prevented ethnic minority parents from vaccinating, compared to White British nonvaccinating parents and vaccinating ethnic minority parents. Methods Interviews with 33 parents (n = 14 ethnic minority non‐vaccinating, n = 10 White British nonvaccinating, and n = 9 ethnic minority vaccinating) ...

  4. Long-term constraints on human activity

    Energy Technology Data Exchange (ETDEWEB)

    Lovins, A. B.

    1976-04-01

    Biophysical and other ''outer limits'' of food, land, water, climatic change, stratospheric chemistry, energy, hazardous substances, non-fuel minerals, human stress, and social and ecological stability raise fundamental questions about present trends in management methods and in global organization. The diverse outer limits reflect complex, poorly perceived, and often unsuspected, interconnections between numerous biological and geophysical processes, many of which are obscure or still unknown. Our lack of predictive power, let alone of quantitative understanding, implies a need to treat essential life-support systems with great caution and forbearance, lest we erode safety margins whose importance we do not yet appreciate. Even those outer limits which now seem remote are relevant to present policy, as their timely avoidance may require us to discard otherwise attractive short-term policies in favor of others that offer less immediate advantage but that retain options which may be needed later. Such alternative policies may have to rely more on social than on technical innovation in order to address underlying disequilibria rather than merely palliating their symptoms. Moreover, some outer limits are sufficiently imminent, or require such long lead-times to avoid, that fundamental changes in policy, in institutions, and in the degree of global interdependence, seem necessary if we are to live to enjoy some of the later and more interesting limits to human activity.

  5. Drone-Augmented Human Vision: Exocentric Control for Drones Exploring Hidden Areas.

    Science.gov (United States)

    Erat, Okan; Isop, Werner Alexander; Kalkofen, Denis; Schmalstieg, Dieter

    2018-04-01

    Drones allow exploring dangerous or impassable areas safely from a distant point of view. However, flight control from an egocentric view in narrow or constrained environments can be challenging. Arguably, an exocentric view would afford a better overview and, thus, more intuitive flight control of the drone. Unfortunately, such an exocentric view is unavailable when exploring indoor environments. This paper investigates the potential of drone-augmented human vision, i.e., of exploring the environment and controlling the drone indirectly from an exocentric viewpoint. If used with a see-through display, this approach can simulate X-ray vision to provide a natural view into an otherwise occluded environment. The user's view is synthesized from a three-dimensional reconstruction of the indoor environment using image-based rendering. This user interface is designed to reduce the cognitive load of the drone's flight control. The user can concentrate on the exploration of the inaccessible space, while flight control is largely delegated to the drone's autopilot system. We assess our system with a first experiment showing how drone-augmented human vision supports spatial understanding and improves natural interaction with the drone.

  6. Human Expeditions to Near-Earth Asteroids: Implications for Exploration, Resource Utilization, Science, and Planetary Defense

    Science.gov (United States)

    Abell, Paul; Mazanek, Dan; Barbee, Brent; Landis, Rob; Johnson, Lindley; Yeomans, Don; Friedensen, Victoria

    2013-01-01

    Over the past several years, much attention has been focused on human exploration of near-Earth asteroids (NEAs) and planetary defence. Two independent NASA studies examined the feasibility of sending piloted missions to NEAs, and in 2009, the Augustine Commission identified NEAs as high profile destinations for human exploration missions beyond the Earth-Moon system as part of the Flexible Path. More recently the current U.S. presidential administration directed NASA to include NEAs as destinations for future human exploration with the goal of sending astronauts to a NEA in the mid to late 2020s. This directive became part of the official National Space Policy of the United States of America as of June 28, 2010. With respect to planetary defence, in 2005 the U.S. Congress directed NASA to implement a survey program to detect, track, and characterize NEAs equal or greater than 140 m in diameter in order to access the threat from such objects to the Earth. The current goal of this survey is to achieve 90% completion of objects equal or greater than 140 m in diameter by 2020.

  7. Robotic and Human-Tended Collaborative Drilling Automation for Subsurface Exploration

    Science.gov (United States)

    Glass, Brian; Cannon, Howard; Stoker, Carol; Davis, Kiel

    2005-01-01

    Future in-situ lunar/martian resource utilization and characterization, as well as the scientific search for life on Mars, will require access to the subsurface and hence drilling. Drilling on Earth is hard - an art form more than an engineering discipline. Human operators listen and feel drill string vibrations coming from kilometers underground. Abundant mass and energy make it possible for terrestrial drilling to employ brute-force approaches to failure recovery and system performance issues. Space drilling will require intelligent and autonomous systems for robotic exploration and to support human exploration. Eventual in-situ resource utilization will require deep drilling with probable human-tended operation of large-bore drills, but initial lunar subsurface exploration and near-term ISRU will be accomplished with lightweight, rover-deployable or standalone drills capable of penetrating a few tens of meters in depth. These lightweight exploration drills have a direct counterpart in terrestrial prospecting and ore-body location, and will be designed to operate either human-tended or automated. NASA and industry now are acquiring experience in developing and building low-mass automated planetary prototype drills to design and build a pre-flight lunar prototype targeted for 2011-12 flight opportunities. A successful system will include development of drilling hardware, and automated control software to operate it safely and effectively. This includes control of the drilling hardware, state estimation of both the hardware and the lithography being drilled and state of the hole, and potentially planning and scheduling software suitable for uncertain situations such as drilling. Given that Humans on the Moon or Mars are unlikely to be able to spend protracted EVA periods at a drill site, both human-tended and robotic access to planetary subsurfaces will require some degree of standalone, autonomous drilling capability. Human-robotic coordination will be important

  8. ASSESSMENT OF HUMAN RESOURCES FOR REGIONAL INNOVATION ACTIVITY

    Directory of Open Access Journals (Sweden)

    R. R. Lukyanova

    2010-03-01

    Full Text Available The paper deals with the issues of human resource development regarding an innovation activity. Concepts of labor and human resources have been surveyed. An integral index for assessment of human resources for regional innovation activity has been developed and assessment of the Russian regions has been made on the basis of it. Development tendencies of modern human resources for innovation activity in Russia have been revealed.

  9. Some Strategic Considerations Related to the Potential Use of Water Resource Deposits on Mars by Future Human Explorers

    Science.gov (United States)

    Beaty, D.W.; Mueller, R.P.; Bussey, D.B.; Davis, R.M.; Hays, L.E.; Hoffman, S.J.

    2016-01-01

    A long-term base on Mars, at the center of an "Exploration Zone", would require substantial quantities of in-situ resources. Although water is not the only resource on Mars of potential interest, it stands out as the one that most dominates long-lead strategic planning. It is needed for multiple purposes for various human activities (including our own survival!), and in significant quantities. The absence of viable deposits could make a surface "field station" logistically unsustainable. Therefore, identification of deposits, and development of the technology needed to make use of these deposits, are an important priority in the period leading up to a human mission to Mars. Given our present understanding of Mars, ice and hydrated minerals appear to be the best potential sources for the quantity of water expected to be needed. The methods for their extraction would be different for these two classes of deposits, and at the present time it is unknown which would ultimately be an optimal solution. The deposits themselves would also ultimately have to be judged by certain economics that take into account information about geologic and engineering attributes and the "cost" of obtaining this information. Ultimately much of this information would need to come from precursor missions, which would be essential if utilization of martian is situ water resources is to become a part of human exploration of Mars.

  10. 78 FR 27427 - Outer Continental Shelf (OCS) Geological and Geophysical Exploration Activities in the Gulf of...

    Science.gov (United States)

    2013-05-10

    ... timeframe. The activities considered within this PEIS are associated with GOM OCS oil and gas exploration... and NMFS as the PEIS is developed. Background: A variety of G&G techniques are used to characterize... surveys are conducted to: (1) Obtain data for hydrocarbon exploration and production; (2) aid in siting...

  11. Human missions to Mars enabling technologies for exploring the red planet

    CERN Document Server

    Rapp, Donald

    2016-01-01

    A mission to send humans to explore the surface of Mars has been the ultimate goal of planetary exploration since the 1950s, when von Braun conjectured a flotilla of 10 interplanetary vessels carrying a crew of at least 70 humans. Since then, more than 1,000 studies were carried out on human missions to Mars, but after 60 years of study, we remain in the early planning stages. The second edition of this book now includes an annotated history of Mars mission studies, with quantitative data wherever possible. Retained from the first edition, Donald Rapp looks at human missions to Mars from an engineering perspective. He divides the mission into a number of stages: Earth’s surface to low-Earth orbit (LEO); departing from LEO toward Mars; Mars orbit insertion and entry, descent and landing; ascent from Mars; trans-Earth injection from Mars orbit and Earth return. For each segment, he analyzes requirements for candidate technologies. In this connection, he discusses the status and potential of a wide range of el...

  12. Oil Exploration and Ethnic Militia activities in the Niger Delta Region ...

    African Journals Online (AJOL)

    User

    dominant source of livelihood of the people in the region. The exploration .... ranging from freedom fighting and Nationalism to activities bordering on criminality. This paper .... a kind of private army whose members are enrolled on military lives ...

  13. Folk-Psychological Interpretation of Human vs. Humanoid Robot Behavior: Exploring the Intentional Stance toward Robots.

    Science.gov (United States)

    Thellman, Sam; Silvervarg, Annika; Ziemke, Tom

    2017-01-01

    People rely on shared folk-psychological theories when judging behavior. These theories guide people's social interactions and therefore need to be taken into consideration in the design of robots and other autonomous systems expected to interact socially with people. It is, however, not yet clear to what degree the mechanisms that underlie people's judgments of robot behavior overlap or differ from the case of human or animal behavior. To explore this issue, participants ( N = 90) were exposed to images and verbal descriptions of eight different behaviors exhibited either by a person or a humanoid robot. Participants were asked to rate the intentionality, controllability and desirability of the behaviors, and to judge the plausibility of seven different types of explanations derived from a recently proposed psychological model of lay causal explanation of human behavior. Results indicate: substantially similar judgments of human and robot behavior, both in terms of (1a) ascriptions of intentionality/controllability/desirability and in terms of (1b) plausibility judgments of behavior explanations; (2a) high level of agreement in judgments of robot behavior - (2b) slightly lower but still largely similar to agreement over human behaviors; (3) systematic differences in judgments concerning the plausibility of goals and dispositions as explanations of human vs. humanoid behavior. Taken together, these results suggest that people's intentional stance toward the robot was in this case very similar to their stance toward the human.

  14. Modelling large scale human activity in San Francisco

    Science.gov (United States)

    Gonzalez, Marta

    2010-03-01

    Diverse group of people with a wide variety of schedules, activities and travel needs compose our cities nowadays. This represents a big challenge for modeling travel behaviors in urban environments; those models are of crucial interest for a wide variety of applications such as traffic forecasting, spreading of viruses, or measuring human exposure to air pollutants. The traditional means to obtain knowledge about travel behavior is limited to surveys on travel journeys. The obtained information is based in questionnaires that are usually costly to implement and with intrinsic limitations to cover large number of individuals and some problems of reliability. Using mobile phone data, we explore the basic characteristics of a model of human travel: The distribution of agents is proportional to the population density of a given region, and each agent has a characteristic trajectory size contain information on frequency of visits to different locations. Additionally we use a complementary data set given by smart subway fare cards offering us information about the exact time of each passenger getting in or getting out of the subway station and the coordinates of it. This allows us to uncover the temporal aspects of the mobility. Since we have the actual time and place of individual's origin and destination we can understand the temporal patterns in each visited location with further details. Integrating two described data set we provide a dynamical model of human travels that incorporates different aspects observed empirically.

  15. Global Proteome Analysis Identifies Active Immunoproteasome Subunits in Human Platelets*

    Science.gov (United States)

    Klockenbusch, Cordula; Walsh, Geraldine M.; Brown, Lyda M.; Hoffman, Michael D.; Ignatchenko, Vladimir; Kislinger, Thomas; Kast, Juergen

    2014-01-01

    The discovery of new functions for platelets, particularly in inflammation and immunity, has expanded the role of these anucleate cell fragments beyond their primary hemostatic function. Here, four in-depth human platelet proteomic data sets were generated to explore potential new functions for platelets based on their protein content and this led to the identification of 2559 high confidence proteins. During a more detailed analysis, consistently high expression of the proteasome was discovered, and the composition and function of this complex, whose role in platelets has not been thoroughly investigated, was examined. Data set mining resulted in identification of nearly all members of the 26S proteasome in one or more data sets, except the β5 subunit. However, β5i, a component of the immunoproteasome, was identified. Biochemical analyses confirmed the presence of all catalytically active subunits of the standard 20S proteasome and immunoproteasome in human platelets, including β5, which was predominantly found in its precursor form. It was demonstrated that these components were assembled into the proteasome complex and that standard proteasome as well as immunoproteasome subunits were constitutively active in platelets. These findings suggest potential new roles for platelets in the immune system. For example, the immunoproteasome may be involved in major histocompatibility complex I (MHC I) peptide generation, as the MHC I machinery was also identified in our data sets. PMID:25146974

  16. Global proteome analysis identifies active immunoproteasome subunits in human platelets.

    Science.gov (United States)

    Klockenbusch, Cordula; Walsh, Geraldine M; Brown, Lyda M; Hoffman, Michael D; Ignatchenko, Vladimir; Kislinger, Thomas; Kast, Juergen

    2014-12-01

    The discovery of new functions for platelets, particularly in inflammation and immunity, has expanded the role of these anucleate cell fragments beyond their primary hemostatic function. Here, four in-depth human platelet proteomic data sets were generated to explore potential new functions for platelets based on their protein content and this led to the identification of 2559 high confidence proteins. During a more detailed analysis, consistently high expression of the proteasome was discovered, and the composition and function of this complex, whose role in platelets has not been thoroughly investigated, was examined. Data set mining resulted in identification of nearly all members of the 26S proteasome in one or more data sets, except the β5 subunit. However, β5i, a component of the immunoproteasome, was identified. Biochemical analyses confirmed the presence of all catalytically active subunits of the standard 20S proteasome and immunoproteasome in human platelets, including β5, which was predominantly found in its precursor form. It was demonstrated that these components were assembled into the proteasome complex and that standard proteasome as well as immunoproteasome subunits were constitutively active in platelets. These findings suggest potential new roles for platelets in the immune system. For example, the immunoproteasome may be involved in major histocompatibility complex I (MHC I) peptide generation, as the MHC I machinery was also identified in our data sets. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

  17. Reference Mission Version 3.0 Addendum to the Human Exploration of Mars: The Reference Mission of the NASA Mars Exploration Study Team. Addendum; 3.0

    Science.gov (United States)

    Drake, Bret G. (Editor)

    1998-01-01

    This Addendum to the Mars Reference Mission was developed as a companion document to the NASA Special Publication 6107, "Human Exploration of Mars: The Reference Mission of the NASA Mars Exploration Study Team." It summarizes changes and updates to the Mars Reference Missions that were developed by the Exploration Office since the final draft of SP 6107 was printed in early 1999. The Reference Mission is a tool used by the exploration community to compare and evaluate approaches to mission and system concepts that could be used for human missions to Mars. It is intended to identify and clarify system drivers, significant sources of cost, performance, risk, and schedule variation. Several alternative scenarios, employing different technical approaches to solving mission and technology challenges, are discussed in this Addendum. Comparing alternative approaches provides the basis for continual improvement to technology investment plan and a general understanding of future human missions to Mars. The Addendum represents a snapshot of work in progress in support of planning for future human exploration missions through May 1998.

  18. Robotic Missions to Small Bodies and Their Potential Contributions to Human Exploration and Planetary Defense

    Science.gov (United States)

    Abell, Paul A.; Rivkin, Andrew S.

    2015-01-01

    Introduction: Robotic missions to small bodies will directly address aspects of NASA's Asteroid Initiative and will contribute to future human exploration and planetary defense. The NASA Asteroid Initiative is comprised of two major components: the Grand Challenge and the Asteroid Mission. The first component, the Grand Challenge, focuses on protecting Earth's population from asteroid impacts by detecting potentially hazardous objects with enough warning time to either prevent them from impacting the planet, or to implement civil defense procedures. The Asteroid Mission involves sending astronauts to study and sample a near-Earth asteroid (NEA) prior to conducting exploration missions of the Martian system, which includes Phobos and Deimos. The science and technical data obtained from robotic precursor missions that investigate the surface and interior physical characteristics of an object will help identify the pertinent physical properties that will maximize operational efficiency and reduce mission risk for both robotic assets and crew operating in close proximity to, or at the surface of, a small body. These data will help fill crucial strategic knowledge gaps (SKGs) concerning asteroid physical characteristics that are relevant for human exploration considerations at similar small body destinations. These data can also be applied for gaining an understanding of pertinent small body physical characteristics that would also be beneficial for formulating future impact mitigation procedures. Small Body Strategic Knowledge Gaps: For the past several years NASA has been interested in identifying the key SKGs related to future human destinations. These SKGs highlight the various unknowns and/or data gaps of targets that the science and engineering communities would like to have filled in prior to committing crews to explore the Solar System. An action team from the Small Bodies Assessment Group (SBAG) was formed specifically to identify the small body SKGs under the

  19. "Dust Devils": Gardening Agents on the Surface of Mars, and Hidden Hazards to Human Exploration?

    Science.gov (United States)

    Marshall, J.; Smith, P.; White, B.; Farrell, W.

    1999-09-01

    at grain boundaries). If dust devils continually loft dust to kilometer heights, and the dust is sprayed into many cubic kilometers of atmosphere each time, could the devils produce a continual background of atmospheric dust that might be mistaken for the fallout of a distant large-scale dust storm? From a human exploration perspective, dust devils are unlikely to pose any, life- threatening situation for an astronaut unfortunate enough to encounter a momentary swirling cloud of loose soil. However, it is noted that pervasive dust is probably one of the greatest long-term hazards for a human encampment. The fineness and penetration capabilities of the dust, its electrostatic adhesive properties, and its complete ubiquity, render the material a persistent nuisance at best, but at worst, over a period of many months it is possible that space suits, machinery, habitat interiors, air filters, and so forth, could become jeopardized. Owing to dust penetration, the space suits used in the Apollo landings were rendered unusable after a few EVA activities. There will be a definite attempt to situate a human colony on Mars in an area that is far removed from the regions of the planet known for being the centers of major dust storms. At the heart of these storm systems, the dust lofting mechanics are unknown, but they are energetic and perhaps potentially life-threatening for an astronaut. Locating a colony in a region that appears from space to be meteorologically benign may lead to colony placement in a region prone to dust devils, but dust devils are not (or have not been) detectable from orbital observations: the region surveyed for placement will appear like the apparently inactive and area referred to earlier. The region may be spared from highly energetic weather systems, but it may not be necessarily immune from continual dust disturbance. Additional information is contained in the original.

  20. Results of the Lunar Exploration Analysis Group (LEAG) Gap Review: Specific Action Team (SAT), Examination of Strategic Knowledge Gaps (SKGs) for Human Exploration of the Moon

    Science.gov (United States)

    Shearer, C. K.; Eppler, D.; Farrell, W.; Gruener, J.; Lawrence, S.; Pellis, N.; Spudis, P. D.; Stopar, J.; Zeigler, R.; Neal, C; hide

    2016-01-01

    The Lunar Exploration Analysis Group (LEAG) was tasked by the Human Exploration Operations Mission Directorate (HEOMD) to establish a Specific Action Team (SAT) to review lunar Strategic Knowledge Gaps (SKGs) within the context of new lunar data and some specific human mission scenarios. Within this review, the SAT was to identify the SKGs that have been fully or partially retired, identify new SKGs resulting from new data and observations, and review quantitative descriptions of measurements that are required to fill knowledge gaps, the fidelity of the measurements needed, and if relevant, provide examples of existing instruments or potential missions capable of filling the SKGs.

  1. The climatic change induced by human activities

    International Nuclear Information System (INIS)

    Balairon Ruiz, L.

    2004-01-01

    The climate of the Earth is a changing climate. Along their history many natural climate changes have existed in all time scales. At the present time we use the term climate changes have existed in all time scales. At the present time we use the term climate change in a restricted way, understanding that we have referring to a singular change that has their origin in the modification of the natural composition of the atmosphere. The increase of greenhouse gases from the second half the XVIII century, is due to the human activities of fossil fuels burning to obtain energy and to industrial and agricultural activities needing for the development of a world which population has been duplicated between 1960 and 2000, until overcoming the 6,000 million inhabitants. In particular, the concentrations of carbon dioxide-CO 2 have increased in a 34%. The more recent emission scenarios proposed by the IPCC (SRES, 2000) are based on hypothesis about the population evolution, the energy consumption and the word patterns of development, which are grouped in four families dominated as A1, A2, B1 and B2. The answer for these scenarios from a range of climate models results in an increase of the world average surface atmospheric temperature between 1,4 degree centigrade and 5,8 degree centigrade and a corresponding sea level rise understood between 9 cm and 88 cm. The changes in the precipitation patterns show us that could be above to the current one in high and media latitudes and below in subtropical latitudes, with exceptions highly depending of the model used. (Author)

  2. Using Pareto optimality to explore the topology and dynamics of the human connectome.

    Science.gov (United States)

    Avena-Koenigsberger, Andrea; Goñi, Joaquín; Betzel, Richard F; van den Heuvel, Martijn P; Griffa, Alessandra; Hagmann, Patric; Thiran, Jean-Philippe; Sporns, Olaf

    2014-10-05

    Graph theory has provided a key mathematical framework to analyse the architecture of human brain networks. This architecture embodies an inherently complex relationship between connection topology, the spatial arrangement of network elements, and the resulting network cost and functional performance. An exploration of these interacting factors and driving forces may reveal salient network features that are critically important for shaping and constraining the brain's topological organization and its evolvability. Several studies have pointed to an economic balance between network cost and network efficiency with networks organized in an 'economical' small-world favouring high communication efficiency at a low wiring cost. In this study, we define and explore a network morphospace in order to characterize different aspects of communication efficiency in human brain networks. Using a multi-objective evolutionary approach that approximates a Pareto-optimal set within the morphospace, we investigate the capacity of anatomical brain networks to evolve towards topologies that exhibit optimal information processing features while preserving network cost. This approach allows us to investigate network topologies that emerge under specific selection pressures, thus providing some insight into the selectional forces that may have shaped the network architecture of existing human brains.

  3. Hematopoietic Stem Cell Therapy as a Counter-Measure for Human Exploration of Deep Space

    Science.gov (United States)

    Ohi, S.; Roach, A.-N.; Ramsahai, S.; Kim, B. C.; Fitzgerald, W.; Riley, D. A.; Gonda, S. R.

    2004-01-01

    Human exploration of deep space depends, in part, on our ability to counter severe/invasive disorders that astronauts experience in space environments. The known symptoms include hematological/cardiac abnormalities,bone and muscle losses, immunodeficiency, neurological disorders, and cancer. Exploiting the extraordinary plasticity of hematopoietic stem cells (HSCs), which differentiate not only to all types of blood cells, but also to various tissues, we have advanced a hypothesis that ome of the space-caused disorders maybe amenable to hematopoietis stem cell therapy(HSCT) so as to maintain promote human exploration of deep space. Using mouse models of human anemia beta-thaiassemia) as well as spaceflight (hindlimb unloading system), we have obtained feasibility results of HSCT for space anemia, muscle loss, and immunodeficiency. For example, in the case of HSCT for muscle loss, the beta-galactosidese marked HSCs were detected in the hindlimbs of unloaded mouse following transplantation by -X-gal wholemaunt staining procedure. Histochemicaland physical analyses indicated structural contribution of HSCs to the muscle. HSCT for immunodeficiency was investigated ising beta-galactosidese gene-tagged Escherichia coli as the infectious agent. Results of the X-gal staining procedure indicated the rapeutic role of the HSCT. To facilitate the HSCT in space, growth of HSCs were optimized in the NASA Rotating Wall Vessel (RWV) culture systems, including Hydrodynamic Focusing Bioreactor (HFB).

  4. Exploring the human body space: A geographical information system based anatomical atlas

    Directory of Open Access Journals (Sweden)

    Antonio Barbeito

    2016-06-01

    Full Text Available Anatomical atlases allow mapping the anatomical structures of the human body. Early versions of these systems consisted of analogical representations with informative text and labeled images of the human body. With computer systems, digital versions emerged and the third and fourth dimensions were introduced. Consequently, these systems increased their efficiency, allowing more realistic visualizations with improved interactivity and functionality. The 4D atlases allow modeling changes over time on the structures represented. The anatomical atlases based on geographic information system (GIS environments allow the creation of platforms with a high degree of interactivity and new tools to explore and analyze the human body. In this study we expand the functions of a human body representation system by creating new vector data, topology, functions, and an improved user interface. The new prototype emulates a 3D GIS with a topological model of the human body, replicates the information provided by anatomical atlases, and provides a higher level of functionality and interactivity. At this stage, the developed system is intended to be used as an educational tool and integrates into the same interface the typical representations of surface and sectional atlases.

  5. Exploring agency beyond humans: the compatibility of Actor-Network Theory (ANT and resilience thinking

    Directory of Open Access Journals (Sweden)

    Angga Dwiartama

    2014-09-01

    Full Text Available At first glance, the compatibility of social theory and resilience thinking is not entirely evident, in part because the ontology of the former is rooted in social interactions among human beings rather than ecological process. Despite this difference, resilience thinking engages with particular aspects of social organization that have generated intense debates within social science, namely the role of humans as integral elements of social-ecological systems and the processes through which given social structures (including material relations are either maintained or transformed. Among social theoretical approaches, Actor-Network Theory (ANT is noted for its distinctive approach to these aspects. ANT proposes that human and nonhuman components (both referred to as actants have the same capacity to influence the development of social-ecological systems (represented as actor-networks by enacting relations and enrolling other actors. We explore the notion of agency that is employed in resilience thinking and ANT in order to extend our understandings of human-environment relationships through complementary insights from each approach. The discussion is illustrated by reference to ongoing assessment of resilience as it is experienced and expressed in two distinctive agricultural production systems: Indonesian rice and New Zealand kiwifruit. We conclude by establishing the potential for ANT to provide more profound theoretical conceptualizations of agency, both human and nonhuman, in analyses of social ecological systems.

  6. Martian Surface Boundary Layer Characterization: Enabling Environmental Data for Science, Engineering and Human Exploration

    Science.gov (United States)

    England, C.

    2000-01-01

    For human or large robotic exploration of Mars, engineering devices such as power sources will be utilized that interact closely with the Martian environment. Heat sources for power production, for example, will use the low ambient temperature for efficient heat rejection. The Martian ambient, however, is highly variable, and will have a first order influence on the efficiency and operation of all large-scale equipment. Diurnal changes in temperature, for example, can vary the theoretical efficiency of power production by 15% and affect the choice of equipment, working fluids, and operating parameters. As part of the Mars Exploration program, missions must acquire the environmental data needed for design, operation and maintenance of engineering equipment including the transportation devices. The information should focus on the variability of the environment, and on the differences among locations including latitudes, altitudes, and seasons. This paper outlines some of the WHY's, WHAT's and WHERE's of the needed data, as well as some examples of how this data will be used. Environmental data for engineering design should be considered a priority in Mars Exploration planning. The Mars Thermal Environment Radiator Characterization (MTERC), and Dust Accumulation and Removal Technology (DART) experiments planned for early Mars landers are examples of information needed for even small robotic missions. Large missions will require proportionately more accurate data that encompass larger samples of the Martian surface conditions. In achieving this goal, the Mars Exploration program will also acquire primary data needed for understanding Martian weather, surface evolution, and ground-atmosphere interrelationships.

  7. Human and Robotic Mission to Small Bodies: Mapping, Planning and Exploration

    Science.gov (United States)

    Neffian, Ara V.; Bellerose, Julie; Beyer, Ross A.; Archinal, Brent; Edwards, Laurence; Lee, Pascal; Colaprete, Anthony; Fong, Terry

    2013-01-01

    This study investigates the requirements, performs a gap analysis and makes a set of recommendations for mapping products and exploration tools required to support operations and scientific discovery for near- term and future NASA missions to small bodies. The mapping products and their requirements are based on the analysis of current mission scenarios (rendezvous, docking, and sample return) and recommendations made by the NEA Users Team (NUT) in the framework of human exploration. The mapping products that sat- isfy operational, scienti c, and public outreach goals include topography, images, albedo, gravity, mass, density, subsurface radar, mineralogical and thermal maps. The gap analysis points to a need for incremental generation of mapping products from low (flyby) to high-resolution data needed for anchoring and docking, real-time spatial data processing for hazard avoidance and astronaut or robot localization in low gravity, high dynamic environments, and motivates a standard for coordinate reference systems capable of describing irregular body shapes. Another aspect investigated in this study is the set of requirements and the gap analysis for exploration tools that support visualization and simulation of operational conditions including soil interactions, environment dynamics, and communications coverage. Building robust, usable data sets and visualisation/simulation tools is the best way for mission designers and simulators to make correct decisions for future missions. In the near term, it is the most useful way to begin building capabilities for small body exploration without needing to commit to specific mission architectures.

  8. Can your country make you sick? Multi-level explorations of population health and human rights in a global perspective

    NARCIS (Netherlands)

    Witvliet, M.I.

    2013-01-01

    Research investigating health and human rights from a socio-epidemiological perspective is emerging. Still there is a noticeable paucity of research that empirically links population health to human rights concerns. In this thesis, three examples relevant to human rights are explored. We investigate

  9. Decision Support System Development for Human Extravehicular Activity

    Data.gov (United States)

    National Aeronautics and Space Administration — The extension of human presence into deep space will depend on how successfully human planetary extravehicular activities (EVAs) are conducted without real-time...

  10. The University Rover Challenge: A competition highlighting Human and Robotic partnerships for exploration

    Science.gov (United States)

    Smith, Heather; Duncan, Andrew

    2016-07-01

    The University Rover Challenge began in 2006 with 4 American college teams competing, now in it's 10th year there are 63 teams from 12 countries registered to compete for the top rover designed to assist humans in the exploration of Mars. The Rovers compete aided by the University teams in four tasks (3 engineering and 1 science) in the Mars analog environment of the Utah Southern Desert in the United States. In this presentation we show amazing rover designs with videos demonstrating the incredible ingenuity, skill and determination of the world's most talented college students. We describe the purpose and results of each of the tasks: Astronaut Assistant, Rover Dexterity, Terrain maneuvering, and Science. We explain the evolution of the competition and common challenges faced by the robotic explorers

  11. Analysis of Gait Pattern to Recognize the Human Activities

    Directory of Open Access Journals (Sweden)

    Jay Prakash Gupta

    2014-09-01

    Full Text Available Human activity recognition based on the computer vision is the process of labelling image sequences with action labels. Accurate systems for this problem are applied in areas such as visual surveillance, human computer interaction and video retrieval. The challenges are due to variations in motion, recording settings and gait differences. Here we propose an approach to recognize the human activities through gait. Activity recognition through Gait is the process of identifying an activity by the manner in which they walk. The identification of human activities in a video, such as a person is walking, running, jumping, jogging etc are important activities in video surveillance. We contribute the use of Model based approach for activity recognition with the help of movement of legs only. Experimental results suggest that our method are able to recognize the human activities with a good accuracy rate and robust to shadows present in the videos.

  12. Enhanced casein kinase II activity in human tumour cell cultures

    DEFF Research Database (Denmark)

    Prowald, K; Fischer, H; Issinger, O G

    1984-01-01

    Casein kinase II (CKII) activity is enhanced as much as 2-3 fold in established and 4-5-fold in transformed human cell lines when compared to that of fibroblasts and primary human tumour cell cultures where CKII activity never exceeded a basic level. The high activity of CKII in transformed cells...

  13. A Delphi-Based Framework for systems architecting of in-orbit exploration infrastructure for human exploration beyond Low Earth Orbit

    Science.gov (United States)

    Aliakbargolkar, Alessandro; Crawley, Edward F.

    2014-01-01

    The current debate in the U.S. Human Spaceflight Program focuses on the development of the next generation of man-rated heavy lift launch vehicles. While launch vehicle systems are of critical importance for future exploration, a comprehensive analysis of the entire exploration infrastructure is required to avoid costly pitfalls at early stages of the design process. This paper addresses this need by presenting a Delphi-Based Systems Architecting Framework for integrated architectural analysis of future in-orbit infrastructure for human space exploration beyond Low Earth Orbit. The paper is structured in two parts. The first part consists of an expert elicitation study to identify objectives for the in-space transportation infrastructure. The study was conducted between November 2011 and January 2012 with 15 senior experts involved in human spaceflight in the United States and Europe. The elicitation study included the formation of three expert panels representing exploration, science, and policy stakeholders engaged in a 3-round Delphi study. The rationale behind the Delphi approach, as imported from social science research, is discussed. Finally, a novel version of the Delphi method is presented and applied to technical decision-making and systems architecting in the context of human space exploration. The second part of the paper describes a tradespace exploration study of in-orbit infrastructure coupled with a requirements definition exercise informed by expert elicitation. The uncertainties associated with technical requirements and stakeholder goals are explicitly considered in the analysis. The outcome of the expert elicitation process portrays an integrated view of perceived stakeholder needs within the human spaceflight community. Needs are subsequently converted into requirements and coupled to the system architectures of interest to analyze the correlation between exploration, science, and policy goals. Pareto analysis is used to identify architectures

  14. Ionizing Radiation Activates AMP-Activated Kinase (AMPK): A Target for Radiosensitization of Human Cancer Cells

    International Nuclear Information System (INIS)

    Sanli, Toran; Rashid, Ayesha; Liu Caiqiong

    2010-01-01

    Purpose: Adenosine monophosphate (AMP)-activated kinase (AMPK) is a molecular energy sensor regulated by the tumor suppressor LKB1. Starvation and growth factors activate AMPK through the DNA damage sensor ataxia-telangiectasia mutated (ATM). We explored the regulation of AMPK by ionizing radiation (IR) and its role as a target for radiosensitization of human cancer cells. Methods and Materials: Lung, prostate, and breast cancer cells were treated with IR (2-8 Gy) after incubation with either ATM or AMPK inhibitors or the AMPK activator metformin. Then, cells were subjected to either lysis and immunoblotting, immunofluorescence microscopy, clonogenic survival assays, or cell cycle analysis. Results: IR induced a robust phosphorylation and activation of AMPK in all tumor cells, independent of LKB1. IR activated AMPK first in the nucleus, and this extended later into cytoplasm. The ATM inhibitor KU-55933 blocked IR activation of AMPK. AMPK inhibition with Compound C or anti-AMPK α subunit small interfering RNA (siRNA) blocked IR induction of the cell cycle regulators p53 and p21 waf/cip as well as the IR-induced G2/M arrest. Compound C caused resistance to IR, increasing the surviving fraction after 2 Gy, but the anti-diabetic drug metformin enhanced IR activation of AMPK and lowered the surviving fraction after 2 Gy further. Conclusions: We provide evidence that IR activates AMPK in human cancer cells in an LKB1-independent manner, leading to induction of p21 waf/cip and regulation of the cell cycle and survival. AMPK appears to (1) participate in an ATM-AMPK-p21 waf/cip pathway, (2) be involved in regulation of the IR-induced G2/M checkpoint, and (3) may be targeted by metformin to enhance IR responses.

  15. The Development of Strategic Thinking: Learning to Impact Human Systems in a Youth Activism Program

    Science.gov (United States)

    Larson, Reed; Hansen, David

    2005-01-01

    Human systems, including institutional systems and informal social networks, are a major arena of modern life. We argue that distinct forms of pragmatic reasoning or "strategic thinking" are required to exercise agency within such systems. This article explores the development of strategic thinking in a youth activism program in which young people…

  16. An exploration in the will psychology of Otto Rank: human intentionality and individuality.

    Science.gov (United States)

    Isono, Masayo

    2012-12-01

    The author explores the meaning and the importance of the will in Rank's relation-based self-creative, self-constructive psychology and argues for the consideration of the concept of the will in psychoanalysis. The paper shows that Rank's concept of the will explains what gives a human being the impetus to choose an action, positive or negative. When validated by the other, this will, the power of intention, enables a person to create his/her unique individuality. The paper reviews Rank's definition of will and traces the evolution of his ideas of intentionality in his writings. Further, the author discusses how Rank attempts to capture the subtle movements of the human mind as suffused with struggles and dynamic interplay between external and internal forces.

  17. Weekend wanderings: Exploring the role of neighborhood design on leisure physical activity of urban youth

    Science.gov (United States)

    Driven largely by concerns over children’s sedentary behavior and high obesity rates, a growing body of literature focuses on the role of the built environment in children’s active commuting trips. Nonetheless, leisure physical activity among youth has been understudied. This paper explores the link...

  18. Policy, Pedagogy, and Priorities: Exploring Stakeholder Perspectives on Active Learning in the Maldives

    Science.gov (United States)

    Di Biase, Rhonda

    2015-01-01

    Challenges of implementing active-learning reform have been reported across a range of countries and include the need for greater attention to contextual factors and practical realities in the reform process. This study investigates how teachers enact active-learning pedagogy within the Maldives. Using design-based research, it explores--through…

  19. Clinical Tolerogenic Dendritic Cells: Exploring Therapeutic Impact on Human Autoimmune Disease

    Directory of Open Access Journals (Sweden)

    Brett Eugene Phillips

    2017-10-01

    Full Text Available Tolerogenic dendritic cell (tDC-based clinical trials for the treatment of autoimmune diseases are now a reality. Clinical trials are currently exploring the effectiveness of tDC to treat autoimmune diseases of type 1 diabetes mellitus, rheumatoid arthritis, multiple sclerosis (MS, and Crohn’s disease. This review will address tDC employed in current clinical trials, focusing on cell characteristics, mechanisms of action, and clinical findings. To date, the publicly reported human trials using tDC indicate that regulatory lymphocytes (largely Foxp3+ T-regulatory cell and, in one trial, B-regulatory cells are, for the most part, increased in frequency in the circulation. Other than this observation, there are significant differences in the major phenotypes of the tDC. These differences may affect the outcome in efficacy of recently launched and impending phase II trials. Recent efforts to establish a catalog listing where tDC converge and diverge in phenotype and functional outcome are an important first step toward understanding core mechanisms of action and critical “musts” for tDC to be therapeutically successful. In our view, the most critical parameter to efficacy is in vivo stability of the tolerogenic activity over phenotype. As such, methods that generate tDC that can induce and stably maintain immune hyporesponsiveness to allo- or disease-specific autoantigens in the presence of powerful pro-inflammatory signals are those that will fare better in primary endpoints in phase II clinical trials (e.g., disease improvement, preservation of autoimmunity-targeted tissue, allograft survival. We propose that pre-treatment phenotypes of tDC in the absence of functional stability are of secondary value especially as such phenotypes can dramatically change following administration, especially under dynamic changes in the inflammatory state of the patient. Furthermore, understanding the outcomes of different methods of cell delivery and sites

  20. Reshaping Human Antibodies: Grafting an Antilysozyme Activity

    Science.gov (United States)

    Verhoeyen, Martine; Milstein, Cesar; Winter, Greg

    1988-03-01

    The production of therapeutic human monoclonal antibodies by hybridoma technology has proved difficult, and this has prompted the ``humanizing'' of mouse monoclonal antibodies by recombinant DNA techniques. It was shown previously that the binding site for a small hapten could be grafted from the heavy-chain variable domain of a mouse antibody to that of a human myeloma protein by transplanting the hypervariable loops. It is now shown that a large binding site for a protein antigen (lysozyme) can also be transplanted from mouse to human heavy chain. The success of such constructions may be facilitated by an induced-fit mechanism.

  1. A Review on Video-Based Human Activity Recognition

    Directory of Open Access Journals (Sweden)

    Shian-Ru Ke

    2013-06-01

    Full Text Available This review article surveys extensively the current progresses made toward video-based human activity recognition. Three aspects for human activity recognition are addressed including core technology, human activity recognition systems, and applications from low-level to high-level representation. In the core technology, three critical processing stages are thoroughly discussed mainly: human object segmentation, feature extraction and representation, activity detection and classification algorithms. In the human activity recognition systems, three main types are mentioned, including single person activity recognition, multiple people interaction and crowd behavior, and abnormal activity recognition. Finally the domains of applications are discussed in detail, specifically, on surveillance environments, entertainment environments and healthcare systems. Our survey, which aims to provide a comprehensive state-of-the-art review of the field, also addresses several challenges associated with these systems and applications. Moreover, in this survey, various applications are discussed in great detail, specifically, a survey on the applications in healthcare monitoring systems.

  2. Effects of human activities on global climate

    Energy Technology Data Exchange (ETDEWEB)

    Kellogg, W W

    1977-01-01

    At present it is difficult to make any predictions for the natural course of climate in the next several decades. However by using climate models, predictions of the cause of climate changes as a result of anthropogenic influences can be made, other external factors remaining the same. Experiments with a number of different models have converged on approximately the same conclusions: the largest single effect of human activities on climate is due to an increase in atmospheric carbon dioxide concentration through fossil fuel combustion, i.e., air and thermal pollution, which contributes to a warming of the lower atmosphere; the best estimate of the warming of the mean surface temperature of the earth is about 1C by 2000 AD and 3C by 2050 AD with 3 to 5 times that increase in polar regions, and an uncertainty of roughly a factor of two. These conclusions assume a continued quasi exponential rate of release of carbon dioxide to the atmosphere. Absorption of the added carbon dioxide is expected to take between 1000 and 1500 years. If all economically recoverable fossil fuel is burned in the next few centuries, the atmospheric concentration of carbon dioxide would increase by 5 to 8 times. An example of a natural warming on a similar scale to that expected in the middle of the next century occurred 4000 to 8000 years ago. Generally there was more rainfall especially over the present sub-tropical deserts, but some regions in middle and high latitudes were drier than now. The extent of Arctic and Antarctic sea ice would be influenced. The total volume of the major ice sheets would change, but a change in sea level cannot yet be predicted with any confidence.

  3. Human fat cell alpha-2 adrenoceptors. I. Functional exploration and pharmacological definition with selected alpha-2 agonists and antagonists

    International Nuclear Information System (INIS)

    Galitzky, J.; Mauriege, P.; Berlan, M.; Lafontan, M.

    1989-01-01

    This study was undertaken to investigate more fully the pharmacological characteristics of the human fat cell alpha-2 adrenoceptor. Biological assays were performed on intact isolated fat cells while radioligand binding studies were carried out with [ 3 H]yohimbine in membranes. These pharmacological studies brought: (1) a critical definition of the limits of the experimental conditions required for the exploration of alpha-2 adrenergic responsiveness on human fat cells and membranes; (2) an improvement in the pharmacological definition of the human fat cell postsynaptic alpha-2 adrenoceptor. Among alpha-2 agonists, UK-14,304 was the most potent and the relative order of potency was: UK-14,304 greater than p-aminoclonidine greater than clonidine = B-HT 920 greater than rilmenidine. For alpha-2 antagonists, the potency order was: yohimbine greater than idazoxan greater than SK ampersand F-86,466 much greater than benextramine; (3) a description of the impact of benextramine (irreversible alpha-1/alpha-2 antagonist) on human fat cell alpha-2 adrenergic receptors and on human fat cell function; the drug inactivates the alpha-2 adrenergic receptors with a minor impact on beta adrenergic receptors and without noticeable alterations of fat cell function as assessed by preservation of beta adrenergic and Al-adenosine receptor-mediated lipolytic responses; and (4) a definition of the relationship existing between alpha-2 adrenergic receptor occupancy, inhibition of adenylate cyclase activity and antilipolysis with full and partial agonists. The existence of a receptor reserve must be taken into account when evaluating alpha-2 adrenergic receptor distribution and regulation of human fat cells

  4. Exploring Global Patterns in Human Appropriation of Net Primary Production Using Earth Observation Satellites and Statistical Data

    Science.gov (United States)

    Imhoff, M.; Bounoua, L.

    2004-12-01

    A unique combination of satellite and socio-economic data were used to explore the relationship between human consumption and the carbon cycle. Biophysical models were applied to consumption data to estimate the annual amount of Earth's terrestrial net primary production humans require for food, fiber and fuel using the same modeling architecture as satellite-supported NPP measurements. The amount of Earth's NPP required to support human activities is a powerful measure of the aggregate human impacts on the biosphere and indicator of societal vulnerability to climate change. Equations were developed estimating the amount of landscape-level NPP required to generate all the products consumed by 230 countries including; vegetal foods, meat, milk, eggs, wood, fuel-wood, paper and fiber. The amount of NPP required was calculated on a per capita basis and projected onto a global map of population to create a spatially explicit map of NPP-carbon demand in units of elemental carbon. NPP demand was compared to a map of Earth's average annual net primary production or supply created using 17 years (1982-1998) of AVHRR vegetation index to produce a geographically accurate balance sheet of terrestrial NPP-carbon supply and demand. Globally, humans consume 20 percent of Earth's total net primary production on land. Regionally the NPP-carbon balance percentage varies from 6 to over 70 percent and locally from near 0 to over 30,000 percent in major urban areas. The uneven distribution of NPP-carbon supply and demand, indicate the degree to which various human populations rely on NPP imports, are vulnerable to climate change and suggest policy options for slowing future growth in NPP demand.

  5. Ubiquitous Geo-Sensing for Context-Aware Analysis: Exploring Relationships between Environmental and Human Dynamics

    Directory of Open Access Journals (Sweden)

    Euro Beinat

    2012-07-01

    Full Text Available Ubiquitous geo-sensing enables context-aware analyses of physical and social phenomena, i.e., analyzing one phenomenon in the context of another. Although such context-aware analysis can potentially enable a more holistic understanding of spatio-temporal processes, it is rarely documented in the scientific literature yet. In this paper we analyzed the collective human behavior in the context of the weather. We therefore explored the complex relationships between these two spatio-temporal phenomena to provide novel insights into the dynamics of urban systems. Aggregated mobile phone data, which served as a proxy for collective human behavior, was linked with the weather data from climate stations in the case study area, the city of Udine, Northern Italy. To identify and characterize potential patterns within the weather-human relationships, we developed a hybrid approach which integrates several spatio-temporal statistical analysis methods. Thereby we show that explanatory factor analysis, when applied to a number of meteorological variables, can be used to differentiate between normal and adverse weather conditions. Further, we measured the strength of the relationship between the ‘global’ adverse weather conditions and the spatially explicit effective variations in user-generated mobile network traffic for three distinct periods using the Maximal Information Coefficient (MIC. The analyses result in three spatially referenced maps of MICs which reveal interesting insights into collective human dynamics in the context of weather, but also initiate several new scientific challenges.

  6. Exploring the Relationship between Human Capital Investment and Corporate Financial Performance of Jordanian Industrial Sectors

    Directory of Open Access Journals (Sweden)

    Faris Nasif ALSHUBIRI

    2013-12-01

    Full Text Available The revolution of globalization, computerization and information technology has entered to Jordanian market. This phenomenon requires company's attention of human element and the acquired knowledge, experience and the development of the so-called concept of intellectual capital.(IC In this study I used only the human capital as a part of IC. This study aims to exploring the relationship between human capital investment (HCI, and corporate financial performance. This study used an 11 industrial sectors listed of Amman Stock Exchange from 2005to 2011. Correlation analysis tests used in this study and the results indicate the high positive significant relationship between HCI and corporate financial performance related to, ROE , PTBV , log of sales , log of assets , DPS and ICR but no significant relationship between HCI and WCTO. The researcher recommends industrial companies to strengthen and stimulate the concept of human capital in the companies and the need for develop administrative innovation program. For future analysis may be used more sectors listed in market in addition used the all parts of intellectual capital related to structural and physical capital with corporate financial performance.

  7. Antarctic Exploration Parallels for Future Human Planetary Exploration: Science Operations Lessons Learned, Planning, and Equipment Capabilities for Long Range, Long Duration Traverses

    Science.gov (United States)

    Hoffman, Stephen J.

    2012-01-01

    The purpose for this workshop can be summed up by the question: Are there relevant analogs to planetary (meaning the Moon and Mars) to be found in polar exploration on Earth? The answer in my opinion is yes or else there would be no reason for this workshop. However, I think some background information would be useful to provide a context for my opinion on this matter. As all of you are probably aware, NASA has been set on a path that, in its current form, will eventually lead to putting human crews on the surface of the Moon and Mars for extended (months to years) in duration. For the past 50 V 60 years, starting not long after the end of World War II, exploration of the Antarctic has accumulated a significant body of experience that is highly analogous to our anticipated activities on the Moon and Mars. This relevant experience base includes: h Long duration (1 year and 2 year) continuous deployments by single crews, h Established a substantial outpost with a single deployment event to support these crews, h Carried out long distance (100 to 1000 kilometer) traverses, with and without intermediate support h Equipment and processes evolved based on lessons learned h International cooperative missions This is not a new or original thought; many people within NASA, including the most recent two NASA Administrators, have commented on the recognizable parallels between exploration in the Antarctic and on the Moon or Mars. But given that level of recognition, relatively little has been done, that I am aware of, to encourage these two exploration communities to collaborate in a significant way. [Slide 4] I will return to NASA s plans and the parallels with Antarctic traverses in a moment, but I want to spend a moment to explain the objective of this workshop and the anticipated products. We have two full days set aside for this workshop. This first day will be taken up with a series of presentations prepared by individuals with experience that extends back as far as the

  8. Transgenic chickens expressing human urokinase-type plasminogen activator.

    Science.gov (United States)

    Lee, Sung Ho; Gupta, Mukesh Kumar; Ho, Young Tae; Kim, Teoan; Lee, Hoon Taek

    2013-09-01

    Urokinase-type plasminogen activator is a serine protease that is clinically used in humans for the treatment of thrombolytic disorders and vascular diseases such as acute ischemic stroke and acute peripheral arterial occlusion. This study explored the feasibility of using chickens as a bioreactor for producing human urokinase-type plasminogen activator (huPA). Recombinant huPA gene, under the control of a ubiquitous Rous sarcoma virus promoter, was injected into the subgerminal cavity of freshly laid chicken eggs at stage X using the replication-defective Moloney murine leukemia virus (MoMLV)-based retrovirus vectors encapsidated with VSV-G (vesicular stomatitis virus G) glycoprotein. A total of 38 chicks, out of 573 virus-injected eggs, hatched and contained the huPA gene in their various body parts. The mRNA transcript of the huPA gene was present in various organs, including blood and egg, and was germ-line transmitted to the next generation. The level of active huPA protein was 16-fold higher in the blood of the transgenic chicken than in the nontransgenic chicken (P huPA protein in eggs increased from 7.82 IU/egg in the G0 generation to 17.02 IU/egg in the G1 generation. However, huPA-expressing embryos had reduced survival and hatchability at d 18 and 21 of incubation, respectively, and the blood clotting time was significantly higher in transgenic chickens than their nontransgenic counterparts (P huPA transgenic chickens could be successfully produced by the retroviral vector system. Transgenic chickens, expressing the huPA under the control of a ubiquitous promoter, may not only be used as a bioreactor for pharming of the huPA drug but also be useful for studying huPA-induced bleeding and other disorders.

  9. Age-related impairments in active learning and strategic visual exploration.

    Science.gov (United States)

    Brandstatt, Kelly L; Voss, Joel L

    2014-01-01

    Old age could impair memory by disrupting learning strategies used by younger individuals. We tested this possibility by manipulating the ability to use visual-exploration strategies during learning. Subjects controlled visual exploration during active learning, thus permitting the use of strategies, whereas strategies were limited during passive learning via predetermined exploration patterns. Performance on tests of object recognition and object-location recall was matched for younger and older subjects for objects studied passively, when learning strategies were restricted. Active learning improved object recognition similarly for younger and older subjects. However, active learning improved object-location recall for younger subjects, but not older subjects. Exploration patterns were used to identify a learning strategy involving repeat viewing. Older subjects used this strategy less frequently and it provided less memory benefit compared to younger subjects. In previous experiments, we linked hippocampal-prefrontal co-activation to improvements in object-location recall from active learning and to the exploration strategy. Collectively, these findings suggest that age-related memory problems result partly from impaired strategies during learning, potentially due to reduced hippocampal-prefrontal co-engagement.

  10. Age-related impairments in active learning and strategic visual exploration

    Directory of Open Access Journals (Sweden)

    Kelly L Brandstatt

    2014-02-01

    Full Text Available Old age could impair memory by disrupting learning strategies used by younger individuals. We tested this possibility by manipulating the ability to use visual-exploration strategies during learning. Subjects controlled visual exploration during active learning, thus permitting the use of strategies, whereas strategies were limited during passive learning via predetermined exploration patterns. Performance on tests of object recognition and object-location recall was matched for younger and older subjects for objects studied passively, when learning strategies were restricted. Active learning improved object recognition similarly for younger and older subjects. However, active learning improved object-location recall for younger subjects, but not older subjects. Exploration patterns were used to identify a learning strategy involving repeat viewing. Older subjects used this strategy less frequently and it provided less memory benefit compared to younger subjects. In previous experiments, we linked hippocampal-prefrontal co-activation to improvements in object-location recall from active learning and to the exploration strategy. Collectively, these findings suggest that age-related memory problems result partly from impaired strategies during learning, potentially due to reduced hippocampal-prefrontal co-engagement.

  11. Human Activity Recognition Using Heterogeneous Sensors

    NARCIS (Netherlands)

    Shoaib, M.

    Physical activities play an important role in our physical and mental well-being. The lack of such activities can negatively affect our well-being. Though people know the importance of physical activities, still they need regular motivational feedback to remain active in their daily life. In order

  12. Human and Robotic Exploration Missions to Phobos Prior to Crewed Mars Surface Missions

    Science.gov (United States)

    Gernhardt, Michael L.; Chappell, Steven P.; Bekdash, Omar S.; Abercromby, Andrew F.

    2016-01-01

    Phobos is a scientifically significant destination that would facilitate the development and operation of the human Mars transportation infrastructure, unmanned cargo delivery systems and other Mars surface systems. In addition to developing systems relevant to Mars surface missions, Phobos offers engineering, operational, and public engagement opportunities that could enhance subsequent Mars surface operations. These opportunities include the use of low latency teleoperations to control Mars surface assets associated with exploration science, human landing-site selection and infrastructure development which may include in situ resource utilization (ISRU) to provide liquid oxygen for the Mars Ascent Vehicle (MAV). A human mission to Mars' moons would be preceded by a cargo predeploy of a surface habitat and a pressurized excursion vehicle (PEV) to Mars orbit. Once in Mars orbit, the habitat and PEV would spiral to Phobos using solar electric propulsion based systems, with the habitat descending to the surface and the PEV remaining in orbit. When a crewed mission is launched to Phobos, it would include the remaining systems to support the crew during the Earth-Mars transit and to reach Phobos after insertion in to Mars orbit. The crew would taxi from Mars orbit to Phobos to join with the predeployed systems in a spacecraft that is based on a MAV, dock with and transfer to the PEV in Phobos orbit, and descend in the PEV to the surface habitat. A static Phobos surface habitat was chosen as a baseline architecture, in combination with the PEV that was used to descend from orbit as the main exploration vehicle. The habitat would, however, have limited capability to relocate on the surface to shorten excursion distances required by the PEV during exploration and to provide rescue capability should the PEV become disabled. To supplement exploration capabilities of the PEV, the surface habitat would utilize deployable EVA support structures that allow astronauts to work

  13. Next Generation Life Support Project: Development of Advanced Technologies for Human Exploration Missions

    Science.gov (United States)

    Barta, Daniel J.

    2012-01-01

    Next Generation Life Support (NGLS) is one of several technology development projects sponsored by the National Aeronautics and Space Administration s Game Changing Development Program. NGLS is developing life support technologies (including water recovery, and space suit life support technologies) needed for humans to live and work productively in space. NGLS has three project tasks: Variable Oxygen Regulator (VOR), Rapid Cycle Amine (RCA) swing bed, and Alternative Water Processing. The selected technologies within each of these areas are focused on increasing affordability, reliability, and vehicle self sufficiency while decreasing mass and enabling long duration exploration. The RCA and VOR tasks are directed at key technology needs for the Portable Life Support System (PLSS) for an Exploration Extravehicular Mobility Unit (EMU), with focus on prototyping and integrated testing. The focus of the Rapid Cycle Amine (RCA) swing-bed ventilation task is to provide integrated carbon dioxide removal and humidity control that can be regenerated in real time during an EVA. The Variable Oxygen Regulator technology will significantly increase the number of pressure settings available to the space suit. Current spacesuit pressure regulators are limited to only two settings while the adjustability of the advanced regulator will be nearly continuous. The Alternative Water Processor efforts will result in the development of a system capable of recycling wastewater from sources expected in future exploration missions, including hygiene and laundry water, based on natural biological processes and membrane-based post treatment. The technologies will support a capability-driven architecture for extending human presence beyond low Earth orbit to potential destinations such as the Moon, near Earth asteroids and Mars.

  14. Technology Development to Support Human Health and Performance in Exploration Beyond Low Earth Orbit

    Science.gov (United States)

    Kundrot, C.E.; Steinberg, S. L.; Charles, J. B.

    2011-01-01

    In the course of defining the level of risks and mitigating the risks for exploration missions beyond low Earth orbit, NASA s Human Research Program (HRP) has identified the need for technology development in several areas. Long duration missions increase the risk of serious medical conditions due to limited options for return to Earth; no resupply; highly limited mass, power, volume; and communication delays. New space flight compatible medical capabilities required include: diagnostic imaging, oxygen concentrator, ventilator, laboratory analysis (saliva, blood, urine), kidney stone diagnosis & treatment, IV solution preparation and delivery. Maintenance of behavioral health in such an isolated, confined and extreme environment requires new sensory stimulation (e.g., virtual reality) technology. Unobtrusive monitoring of behavioral health and treatment methods are also required. Prolonged exposure to weightlessness deconditions bone, muscle, and the cardiovascular system. Novel exercise equipment or artificial gravity are necessary to prevent deconditioning. Monitoring of the degree of deconditioning is required to ensure that countermeasures are effective. New technologies are required in all the habitable volumes (e.g., suit, capsule, habitat, exploration vehicle, lander) to provide an adequate food system, and to meet human environmental standards for air, water, and surface contamination. Communication delays require the crew to be more autonomous. Onboard decision support tools that assist crew with real-time detection and diagnosis of vehicle and habitat operational anomalies will enable greater autonomy. Multi-use shield systems are required to provide shielding from solar particle events. The HRP is pursuing the development of these technologies in laboratories, flight analog environments and the ISS so that the human health and performance risks will be acceptable with the available resources.

  15. Affinity purification of recombinant human plasminogen activator ...

    African Journals Online (AJOL)

    rhPA from milk, and should be useful for purifying other tPA mutants or other .... explorer system with UV detector (280 nm), ..... induced fibrinolysis is enhanced in patients with breast, ... crystallization of yeast RNA polymerase II, Proc Natl.

  16. Low-latency Science Exploration of Planetary Bodies: a Demonstration Using ISS in Support of Mars Human Exploration

    Science.gov (United States)

    Thronson, Harley A.; Valinia, Azita; Bleacher, Jacob; Eigenbrode, Jennifer; Garvin, Jim; Petro, Noah

    2014-01-01

    We summarize a proposed experiment to use the International Space Station to formally examine the application and validation of low-latency telepresence for surface exploration from space as an alternative, precursor, or potentially as an adjunct to astronaut "boots on the ground." The approach is to develop and propose controlled experiments, which build upon previous field studies and which will assess the effects of different latencies (0 to 500 msec), task complexity, and alternate forms of feedback to the operator. These experiments serve as an example of a pathfinder for NASA's roadmap of missions to Mars with low-latency telerobotic exploration as a precursor to astronaut's landing on the surface to conduct geological tasks.

  17. Human activities threatening the biodiversity of the Uzungwa Scarp ...

    African Journals Online (AJOL)

    Studies of human activities in the Uzungwa Scarp Forest Reserve, Udzungwa Mountains, were conducted in March-April and September 1997, in the western and southern parts of the forest. Different human activities, such as timber and pole cutting and withies harvesting, as well as the collection of non-timber forest ...

  18. Exploring the current application of professional competencies in human resource management in the South African context

    Directory of Open Access Journals (Sweden)

    Nico Schutte

    2015-11-01

    Full Text Available Orientation: Human research (HR practitioners have an important role to play in the sustainability and competitiveness of organisations. Yet their strategic contribution and the value they add remain unrecognised. Research purpose: The main objective of this research was to explore the extent to which HR practitioners are currently allowed to display HR competencies in the workplace, and whether any significant differences exist between perceived HR competencies, based on the respondents’ demographic characteristics. Motivation for the study: Limited empirical research exists on the extent to which HR practitioners are allowed to display key competencies in the South African workplace. Research approach, design, and method: A quantitative research approach was followed. A Human Resource Management Professional Competence Questionnaire was administered to HR practitioners and managers (N = 481. Main findings: The results showed that HR competencies are poorly applied in selected South African workplaces. The competencies that were indicated as having the poorest application were talent management, HR metrics, HR business knowledge, and innovation. The white ethic group experienced a poorer application of all human research management (HRM competencies compared to the black African ethnic group. Practical/managerial implications: The findings of the research highlighted the need for management to evaluate the current application of HR practices in the workplace and also the extent to which HR professionals are involved as strategic business partners. Contribution/value-add: This research highlights the need for the current application of HR competencies in South African workplaces to be improved.

  19. The Potential Impact of Mars' Atmospheric Dust on Future Human Exploration of the Red Planet

    Science.gov (United States)

    Winterhalter, D.; Levine, J. S.; Kerschmann, R.; Beaty, D. W.; Carrier, B. L.; Ashley, J. W.

    2017-12-01

    With the increasing focus by NASA and other space agencies on a crewed mission to Mars in the 2039 time-frame, many Mars-specific environmental factors are now starting to be considered by NASA and other engineering teams. Learning from NASA's Apollo Missions to the Moon, where lunar dust turned out to be a significant challenge to mission and crew safety, attention is now turning to the dust in Mars' atmosphere and regolith. To start the process of identifying possible dust-caused challenges to the human presence on Mars, and thus aid early engineering and mission design efforts, the NASA Engineering and Safety Center (NESC) Robotic Spacecraft Technical Discipline Team organized and conducted a Workshop on the "Dust in Mars' Atmosphere and Its Impact on the Human Exploration of Mars", held at the Lunar and Planetary Institute (LPI), Houston, TX, June 13-15, 2017. The workshop addressed the following general areas: 1. What is known about Mars' dust in terms of its physical and chemical properties, its local and global abundance and composition, and its variability.2. What is the impact of Mars atmospheric dust on human health.3. What is the impact of Mars atmospheric dust on surface mechanical systems (e.g., spacesuits, habitats, mobility systems, etc.). We present the top priority issues identified in the workshop.

  20. Exploring the Human Ecology of the Younger Dryas Extraterrestrial Impact Event

    Science.gov (United States)

    Kennett, D. J.; Erlandson, J. M.; Braje, T. J.; Culleton, B. J.

    2007-05-01

    Several lines of evidence now exist for a major extraterrestrial impact event in North America at 12.9 ka (the YDB). This impact partially destabilized the Laurentide and Cordilleran ice sheets, triggered abrupt Younger Dryas cooling and extensive wildfires, and contributed to megafaunal extinction. This event also occurred soon after the well established colonization of the Americas by anatomically modern humans. Confirmation of this event would represent the first near-time extraterrestrial impact with significant effects on human populations. These likely included widespread, abrupt human mortality, population displacement, migration into less effected or newly established habitats, loss of cultural traditions, and resource diversification in the face of the massive megafaunal extinction and population reductions in surviving animal populations. Ultimately, these transformations established the context for the special character of plant and animal domestication and the emergence of agricultural economies in North America. We explore the Late Pleistocene archaeological record in North America within the context of documented major biotic changes associated with the YDB in North America and of the massive ecological affects hypothesized for this event.

  1. Analog Testing of Operations Concepts for Mitigation of Communication Latency During Human Space Exploration

    Science.gov (United States)

    Chappell, Steven P.; Abercromby, Andrew F.; Miller, Matthew J.; Halcon, Christopher; Gernhardt, Michael L.

    2016-01-01

    OBJECTIVES: NASA Extreme Environment Mission Operations (NEEMO) is an underwater spaceflight analog that allows a true mission-like operational environment and uses buoyancy effects and added weight to simulate different gravity levels. Three missions were undertaken from 2014-2015, NEEMO's 18-20. All missions were performed at the Aquarius undersea research habitat. During each mission, the effects of varying operations concepts and tasks type and complexity on representative communication latencies associated with Mars missions were studied. METHODS: 12 subjects (4 per mission) were weighed out to simulate near-zero or partial gravity extravehicular activity (EVA) and evaluated different operations concepts for integration and management of a simulated Earth-based science backroom team (SBT) to provide input and direction during exploration activities. Exploration traverses were planned in advance based on precursor data collected. Subjects completed science-related tasks including presampling surveys, geologic-based sampling, and marine-based sampling as a portion of their tasks on saturation dives up to 4 hours in duration that were to simulate extravehicular activity (EVA) on Mars or the moons of Mars. One-way communication latencies, 5 and 10 minutes between space and mission control, were simulated throughout the missions. Objective data included task completion times, total EVA times, crew idle time, translation time, SBT assimilation time (defined as time available for SBT to discuss data/imagery after it has been collected, in addition to the time taken to watch imagery streaming over latency). Subjective data included acceptability, simulation quality, capability assessment ratings, and comments. RESULTS: Precursor data can be used effectively to plan and execute exploration traverse EVAs (plans included detailed location of science sites, high-fidelity imagery of the sites, and directions to landmarks of interest within a site). Operations concepts that

  2. NEEMO 18-20: Analog Testing for Mitigation of Communication Latency During Human Space Exploration

    Science.gov (United States)

    Chappell, Steven P.; Beaton, Kara H.; Miller, Matthew J.; Graff, Trevor G.; Abercromby, Andrew F. J.; Gernhardt, Michael L.; Halcon, Christopher

    2016-01-01

    NASA Extreme Environment Mission Operations (NEEMO) is an underwater spaceflight analog that allows a true mission-like operational environment and uses buoyancy effects and added weight to simulate different gravity levels. Three missions were undertaken from 2014-2015, NEEMO's 18-20. All missions were performed at the Aquarius undersea research habitat. During each mission, the effects of communication latencies on operations concepts, timelines, and tasks were studied. METHODS: Twelve subjects (4 per mission) were weighed out to simulate near-zero or partial gravity extravehicular activity (EVA) and evaluated different operations concepts for integration and management of a simulated Earth-based science team (ST) to provide input and direction during exploration activities. Exploration traverses were preplanned based on precursor data. Subjects completed science-related tasks including pre-sampling surveys, geologic-based sampling, and marine-based sampling as a portion of their tasks on saturation dives up to 4 hours in duration that were designed to simulate extravehicular activity (EVA) on Mars or the moons of Mars. One-way communication latencies, 5 and 10 minutes between space and mission control, were simulated throughout the missions. Objective data included task completion times, total EVA times, crew idle time, translation time, ST assimilation time (defined as time available for ST to discuss data/imagery after data acquisition). Subjective data included acceptability, simulation quality, capability assessment ratings, and comments. RESULTS: Precursor data can be used effectively to plan and execute exploration traverse EVAs (plans included detailed location of science sites, high-fidelity imagery of the sites, and directions to landmarks of interest within a site). Operations concepts that allow for pre-sampling surveys enable efficient traverse execution and meaningful Mission Control Center (MCC) interaction across communication latencies and can be

  3. A potential human hepatocellular carcinoma inhibitor from Bauhinia purpurea L. seeds: from purification to mechanism exploration.

    Science.gov (United States)

    Fang, Evandro Fei; Bah, Clara Shui Fern; Wong, Jack Ho; Pan, Wen Liang; Chan, Yau Sang; Ye, Xiu Juan; Ng, Tzi Bun

    2012-02-01

    A 20-kDa Kunitz-type trypsin-chymotrypsin inhibitor, Bauhinia purpurea trypsin inhibitor (BPLTI), has been isolated from the seeds of B. purpurea L. by using liquid chromatography procedures that involved ion exchange chromatography on Sp-Sepharose and Mono S and gel filtration on Superdex 75. BPLTI demonstrated protease inhibitory activities of 7226 BAEE units/mg and 65 BTEE units/mg toward trypsin and α-chymotrypsin, respectively. BPLTI was relatively thermal (0-60°C) and pH (3-10) stable and its activity could be decreased by dithiothreitol treatment. BPLTI exhibited a wide spectrum of anti-proliferative and pro-apoptotic activities especially on human hepatocellular carcinoma Hep G2 cells. However, it was devoid of a significant antiproliferative effect on immortal human hepatic WRL 68 cells. We show here that BPLTI stimulates apoptosis in Hep G2 cells, including (1) evoking DNA damage including the production of chromatin condensation and apoptotic bodies; (2) induction of cell apoptosis/necrosis; (3) mitochondrial membrane depolarization; and (4) increasing the production of cytokines. Taken together, our findings show for the first time that purified protease inhibitor from B. purpurea L. seeds is a promising candidate for the treatment of human hepatocellular carcinoma.

  4. Analysis of the intellectual structure of human space exploration research using a bibliometric approach: Focus on human related factors

    Science.gov (United States)

    Lee, Tai Sik; Lee, Yoon-Sun; Lee, Jaeho; Chang, Byung Chul

    2018-02-01

    Human space exploration (HSE) is an interdisciplinary field composed of a range of subjects that have developed dramatically over the last few decades. This paper investigates the intellectual structure of HSE research with a focus on human related factors. A bibliometric approach with quantitative analytical techniques is applied to study the development and growth of the research. This study retrieves 1921 papers on HSE related to human factors from the year 1990 to the year 2016 from Web of Science and constructs a critical citation network composed of 336 papers. Edge-betweenness-based clustering is used to classify the citation network into twelve distinct research clusters based on four research themes: "biological risks from space radiation," "health and performance during long-duration spaceflight," "program and in-situ resources for HSE missions," and "habitat and life support systems in the space environment." These research themes are also similar to the classification results of a co-occurrence analysis on keywords for a total of 1921 papers. Papers with high centrality scores are identified as important papers in terms of knowledge flow. Moreover, the intermediary role of papers in exchanging knowledge between HSE sub-areas is identified using brokerage analysis. The key-route main path highlights the theoretical development trajectories. Due to the recent dramatic increase in investment by international governments and the private sector, the theoretical development trajectories of key research themes have been expanding from furthering scientific and technical knowledge to include various social and economic issues, thus encouraging massive public participation. This study contributes to an understanding of research trends and popular issues in the field of HSE by introducing a powerful way of determining major research themes and development trajectories. This study will help researchers seek the underlying knowledge diffusion flow from multifaceted

  5. Tonic noradrenergic activity modulates explorative behavior and attentional set shifting: Evidence from pupillometry and gaze pattern analysis.

    Science.gov (United States)

    Pajkossy, Péter; Szőllősi, Ágnes; Demeter, Gyula; Racsmány, Mihály

    2017-12-01

    A constant task for every living organism is to decide whether to exploit rewards associated with current behavior or to explore the environment for more rewarding options. Current empirical evidence indicates that exploitation is related to phasic whereas exploration is related to tonic firing mode of noradrenergic neurons in the locus coeruleus. In humans, this exploration-exploitation trade-off is subserved by the ability to flexibly switch attention between task-related and task-irrelevant information. Here, we investigated whether this function, called attentional set shifting, is related to exploration and tonic noradrenergic discharge. We measured pretrial baseline pupil dilation, proved to be strongly correlated with the activity of the locus coeruleus, while human participants took part in well-known tasks of attentional set shifting. Study 1 used the Wisconsin Card Sorting Task, whereas in Study 2, the Intra/Extradimensional Set Shifting Task was used. Both tasks require participants to choose between different compound stimuli based on feedback provided for their previous decisions. During the task, stimulus-reward contingencies change periodically, thus participants are repeatedly required to reassess which stimulus features are relevant (i.e., they shift their attentional set). Our results showed that baseline pupil diameter steadily decreased when the stimulus-reward contingencies were stable, whereas they suddenly increased when these contingencies changed. Analysis of looking patterns also confirmed the presence of exploratory behavior during attentional set shifting. Thus, our results suggest that tonic firing mode of noradrenergic neurons in the locus coeruleus is implicated in attentional set shifting, as it regulates the amount of exploration. © 2017 Society for Psychophysiological Research.

  6. Focusing elementary students with active classrooms: exploring teachers’ perceptions of self-initiated practices

    Directory of Open Access Journals (Sweden)

    Christine A. Foran

    2017-09-01

    Full Text Available The aim of our study was to explore the perceptions of elementary teachers who routinely prioritized physical activity in their classrooms. Researchers are reporting improved student academic test results following physical activity sessions, however, classroom teachers are challenged in balancing curricular and other expectations. Hence, teachers who voluntarily implement physical activity have views that are unique and important for promoting the practice to others. We interviewed seven teachers from grades 1-6, using the qualitative constructivist approach to grounded theory qualitative research. Teachers valued physical activity because it enhanced their students’ focus on classroom activities. Common attributes amongst the teachers were active lifestyles, previous employment experiencesusing physical activity, and a pedagogical approach prioritizing physical activity throughout the day. Additionally, the teachers perceived that belonging to schools with a culture of movement was important. Teachers view physical activity as a teaching asset when they perceive a positive impact on their students’ ability to focus. Specific teacher attributes and a school environment that embraces physical activity may predispose teachers to these views, and represent areas that should be further explored. Pre-service courses could be one way to provide teachers with experience and a repertoire of easy physical activities.

  7. The possible environmental impacts of petroleum exploration activities on the Georges Bank ecosystem

    International Nuclear Information System (INIS)

    Boudreau, P.R.; Gordon, D.C.; Harding, G.C.

    1999-01-01

    This document contains a description of the Georges Bank ecosystem, the potential environmental impacts from petroleum exploration activities and the scientific information gathered to support a series of recommendations offered by the review panel. Input has been provided by Canadian and US government scientists, external reviewers, representatives of commercial fishing and petroleum industries. The overall consensus is that petroleum exploration activity might affect fish catch rates and spawning behaviour, however, such impacts are likely to be temporary and localized. Exploration drilling would cause a temporary loss of access to some fishing grounds, while seismic activity is likely to lead to some temporary space conflicts with fishing activity, especially during the summer months. Seismic activity could also impact on eggs and larvae of aquatic organisms, the extent depending on time of year and location. Large release of petroleum products from well blowout was considered unlikely. If occurred, it might affect population and ecosystem levels. Environmental impacts from production activities were not included in this assessment, however, they are believed to be substantially different from exploratory activities. Such impacts will be dependent upon the product being produced, the market, and the available technology. 140 refs., tabs., figs

  8. An Exploration of Human Well-Being Bundles as Identifiers of Ecosystem Service Use Patterns.

    Directory of Open Access Journals (Sweden)

    Maike Hamann

    Full Text Available We take a social-ecological systems perspective to investigate the linkages between ecosystem services and human well-being in South Africa. A recent paper identified different types of social-ecological systems in the country, based on distinct bundles of ecosystem service use. These system types were found to represent increasingly weak direct feedbacks between nature and people, from rural "green-loop" communities to urban "red-loop" societies. Here we construct human well-being bundles and explore whether the well-being bundles can be used to identify the same social-ecological system types that were identified using bundles of ecosystem service use. Based on national census data, we found three distinct well-being bundle types that are mainly characterized by differences in income, unemployment and property ownership. The distribution of these well-being bundles approximates the distribution of ecosystem service use bundles to a substantial degree: High levels of income and education generally coincided with areas characterised by low levels of direct ecosystem service use (or red-loop systems, while the majority of low well-being areas coincided with medium and high levels of direct ecosystem service use (or transition and green-loop systems. However, our results indicate that transformations from green-loop to red-loop systems do not always entail an immediate improvement in well-being, which we suggest may be due to a time lag between changes in the different system components. Using human well-being bundles as an indicator of social-ecological dynamics may be useful in other contexts since it is based on socio-economic data commonly collected by governments, and provides important insights into the connections between ecosystem services and human well-being at policy-relevant sub-national scales.

  9. An Exploration of Human Well-Being Bundles as Identifiers of Ecosystem Service Use Patterns.

    Science.gov (United States)

    Hamann, Maike; Biggs, Reinette; Reyers, Belinda

    2016-01-01

    We take a social-ecological systems perspective to investigate the linkages between ecosystem services and human well-being in South Africa. A recent paper identified different types of social-ecological systems in the country, based on distinct bundles of ecosystem service use. These system types were found to represent increasingly weak direct feedbacks between nature and people, from rural "green-loop" communities to urban "red-loop" societies. Here we construct human well-being bundles and explore whether the well-being bundles can be used to identify the same social-ecological system types that were identified using bundles of ecosystem service use. Based on national census data, we found three distinct well-being bundle types that are mainly characterized by differences in income, unemployment and property ownership. The distribution of these well-being bundles approximates the distribution of ecosystem service use bundles to a substantial degree: High levels of income and education generally coincided with areas characterised by low levels of direct ecosystem service use (or red-loop systems), while the majority of low well-being areas coincided with medium and high levels of direct ecosystem service use (or transition and green-loop systems). However, our results indicate that transformations from green-loop to red-loop systems do not always entail an immediate improvement in well-being, which we suggest may be due to a time lag between changes in the different system components. Using human well-being bundles as an indicator of social-ecological dynamics may be useful in other contexts since it is based on socio-economic data commonly collected by governments, and provides important insights into the connections between ecosystem services and human well-being at policy-relevant sub-national scales.

  10. Extendable supervised dictionary learning for exploring diverse and concurrent brain activities in task-based fMRI.

    Science.gov (United States)

    Zhao, Shijie; Han, Junwei; Hu, Xintao; Jiang, Xi; Lv, Jinglei; Zhang, Tuo; Zhang, Shu; Guo, Lei; Liu, Tianming

    2018-06-01

    Recently, a growing body of studies have demonstrated the simultaneous existence of diverse brain activities, e.g., task-evoked dominant response activities, delayed response activities and intrinsic brain activities, under specific task conditions. However, current dominant task-based functional magnetic resonance imaging (tfMRI) analysis approach, i.e., the general linear model (GLM), might have difficulty in discovering those diverse and concurrent brain responses sufficiently. This subtraction-based model-driven approach focuses on the brain activities evoked directly from the task paradigm, thus likely overlooks other possible concurrent brain activities evoked during the information processing. To deal with this problem, in this paper, we propose a novel hybrid framework, called extendable supervised dictionary learning (E-SDL), to explore diverse and concurrent brain activities under task conditions. A critical difference between E-SDL framework and previous methods is that we systematically extend the basic task paradigm regressor into meaningful regressor groups to account for possible regressor variation during the information processing procedure in the brain. Applications of the proposed framework on five independent and publicly available tfMRI datasets from human connectome project (HCP) simultaneously revealed more meaningful group-wise consistent task-evoked networks and common intrinsic connectivity networks (ICNs). These results demonstrate the advantage of the proposed framework in identifying the diversity of concurrent brain activities in tfMRI datasets.

  11. Human Activity Recognition in AAL Environments Using Random Projections

    Directory of Open Access Journals (Sweden)

    Robertas Damaševičius

    2016-01-01

    Full Text Available Automatic human activity recognition systems aim to capture the state of the user and its environment by exploiting heterogeneous sensors attached to the subject’s body and permit continuous monitoring of numerous physiological signals reflecting the state of human actions. Successful identification of human activities can be immensely useful in healthcare applications for Ambient Assisted Living (AAL, for automatic and intelligent activity monitoring systems developed for elderly and disabled people. In this paper, we propose the method for activity recognition and subject identification based on random projections from high-dimensional feature space to low-dimensional projection space, where the classes are separated using the Jaccard distance between probability density functions of projected data. Two HAR domain tasks are considered: activity identification and subject identification. The experimental results using the proposed method with Human Activity Dataset (HAD data are presented.

  12. Human Activity Recognition in AAL Environments Using Random Projections.

    Science.gov (United States)

    Damaševičius, Robertas; Vasiljevas, Mindaugas; Šalkevičius, Justas; Woźniak, Marcin

    2016-01-01

    Automatic human activity recognition systems aim to capture the state of the user and its environment by exploiting heterogeneous sensors attached to the subject's body and permit continuous monitoring of numerous physiological signals reflecting the state of human actions. Successful identification of human activities can be immensely useful in healthcare applications for Ambient Assisted Living (AAL), for automatic and intelligent activity monitoring systems developed for elderly and disabled people. In this paper, we propose the method for activity recognition and subject identification based on random projections from high-dimensional feature space to low-dimensional projection space, where the classes are separated using the Jaccard distance between probability density functions of projected data. Two HAR domain tasks are considered: activity identification and subject identification. The experimental results using the proposed method with Human Activity Dataset (HAD) data are presented.

  13. ["Grounded theory" develops medicine. Popular research method for exploring human behavior can discover new connections].

    Science.gov (United States)

    Thulesius, Hans; Barfod, Toke; Ekström, Helene; Håkansson, Anders

    2004-09-30

    Grounded theory (GT) is a popular research method for exploring human behavior. GT was developed by the medical sociologists Glaser and Strauss while they studied dying in hospitals in the 1960s resulting in the book "Awareness of dying". The goal of a GT is to generate conceptual theories by using all types of data but without applying existing theories and hypotheses. GT procedures are mostly inductive as opposed to deductive research where hypotheses are tested. A good GT has a core variable that is a central concept connected to many other concepts explaining the main action in the studied area. A core variable answers the question "What's going on?". Examples of core variables are: "Cutting back after a heart attack"--how people adapt to life after a serious illness; and "Balancing in palliative cancer care"--a process of weighing, shifting, compensating and compromising when treating people with a progressive and incurable illness trajectory.

  14. The development of the human exploration demonstration project (HEDP), a planetary systems testbed

    Science.gov (United States)

    Chevers, Edward S.; Korsmeyer, David J.

    1993-01-01

    The Human Exploration Demonstration Project (HEDP) is an ongoing task at the National Aeronautics and Space Administration's Ames Research Center to address the advanced technology requirements necessary to implement an integrated working and living environment for a planetary surface habitat. The integrated environment will consist of life support systems, physiological monitoring of project crew, a virtual environment workstation, and centralized data acquisition and habitat systems health monitoring. There will be several robotic systems on a simulated planetary landscape external to the habitat environment to provide representative work loads for the crew. This paper describes the status of the HEDP after one year, the major facilities composing the HEDP, the project's role as an Ames Research Center testbed, and the types of demonstration scenarios that will be run to showcase the technologies.

  15. Exploring the Usefulness of Corporate Online Social Networks in the Human Resource Management

    Directory of Open Access Journals (Sweden)

    Slaviša Sovilj

    2014-04-01

    who represent the nodes of communication, but also provides a wealth of information on employees or those who are interested in the right jobs, who use social networks to post information about themselves. This paper explored the possibility of obtaining information relevant to the selection of internal human resources based on an analysis of corporate online social networks. Research methods are taken from the field of graph theory and social network analysis (SNA, whereas in addition to quantitative parameters of nodes also additional dimensions of data filtering are considered. This approach is called the extended SNA. In addition to demonstrating and explaining, the extended SNA has developed an application that simulates the communication between employees within a corporation, for the analysis and detection of suitable employees, and visualizes the results in the form of a graph.

  16. Brain activation during human male ejaculation

    NARCIS (Netherlands)

    Holstege, Ger; Georgiadis, Janniko R.; Paans, Anne M.J.; Meiners, Linda C.; Graaf, Ferdinand H.C.E. van der; Reinders, A.A.T.Simone

    2003-01-01

    Brain mechanisms that control human sexual behavior in general, and ejaculation in particular, are poorly understood. We used positron emission tomography to measure increases in regional cerebral blood flow (rCBF) during ejaculation compared with sexual stimulation in heterosexual male volunteers.

  17. The Nuclear Thermal Propulsion Stage (NTPS): A Key Space Asset for Human Exploration and Commercial Missions to the Moon

    Science.gov (United States)

    Borowski, Stanley K.; McCurdy, David R.; Burke, Laura M.

    2014-01-01

    The nuclear thermal rocket (NTR) has frequently been discussed as a key space asset that can bridge the gap between a sustained human presence on the Moon and the eventual human exploration of Mars. Recently, a human mission to a near Earth asteroid (NEA) has also been included as a "deep space precursor" to an orbital mission of Mars before a landing is attempted. In his "post-Apollo" Integrated Space Program Plan (1970 to 1990), Wernher von Braun, proposed a reusable Nuclear Thermal Propulsion Stage (NTPS) to deliver cargo and crew to the Moon to establish a lunar base initially before sending human missions to Mars. The NTR was selected because it was a proven technology capable of generating both high thrust and high specific impulse (Isp approx. 900 s)-twice that of today's best chemical rockets. During the Rover and NERVA programs, 20 rocket reactors were designed, built and successfully ground tested. These tests demonstrated the (1) thrust levels; (2) high fuel temperatures; (3) sustained operation; (4) accumulated lifetime; and (5) restart capability needed for an affordable in-space transportation system. In NASA's Mars Design Reference Architecture (DRA) 5.0 study, the "Copernicus" crewed NTR Mars transfer vehicle used three 25 klbf "Pewee" engines-the smallest and highest performing engine tested in the Rover program. Smaller lunar transfer vehicles-consisting of a NTPS with three approx. 16.7 klbf "SNRE-class" engines, an in-line propellant tank, plus the payload-can be delivered to LEO using a 70 t to LEO upgraded SLS, and can support reusable cargo delivery and crewed lunar landing missions. The NTPS can play an important role in returning humans to the Moon to stay by providing an affordable in-space transportation system that can allow initial lunar outposts to evolve into settlements capable of supporting commercial activities. Over the next decade collaborative efforts between NASA and private industry could open up new exploration and commercial

  18. The Aerial Regional-Scale Environmental Surveyor (ARES): New Mars Science to Reduce Human Risk and Prepare for the Human Exploration

    Science.gov (United States)

    Levine, Joel S.; Croom, Mark A.; Wright, Henry S.; Killough, B. D.; Edwards, W. C.

    2012-01-01

    Obtaining critical measurements for eventual human Mars missions while expanding upon recent Mars scientific discoveries and deriving new scientific knowledge from a unique near surface vantage point is the focus of the Aerial Regional-scale Environmental Surveyor (ARES) exploration mission. The key element of ARES is an instrumented,rocket-powered, well-tested robotic airplane platform, that will fly between one to two kilometers above the surface while traversing hundreds of kilometers to collect and transmit previously unobtainable high spatial measurements relevant to the NASA Mars Exploration Program and the exploration of Mars by humans.

  19. Dive Activities from Cruise Information Management System (CIMS) for Estuary to the Abyss 2004: Exploring Along the Latitude 31-30 Transect - Office of Ocean Exploration

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Information about dive activities were recorded into the Cruise Information Management System (CIMS) by the NOAA Office of Ocean Exploration's data manager during...

  20. Dive Activities from Cruise Information Management System (CIMS) for Life on the Edge 2003: Exploring Deep Ocean Habitats - Office of Ocean Exploration

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Information about dive activities were recorded into the Cruise Information Management System (CIMS) by the NOAA Office of Ocean Exploration's data manager during...

  1. Window Size Impact in Human Activity Recognition

    Directory of Open Access Journals (Sweden)

    Oresti Banos

    2014-04-01

    Full Text Available Signal segmentation is a crucial stage in the activity recognition process; however, this has been rarely and vaguely characterized so far. Windowing approaches are normally used for segmentation, but no clear consensus exists on which window size should be preferably employed. In fact, most designs normally rely on figures used in previous works, but with no strict studies that support them. Intuitively, decreasing the window size allows for a faster activity detection, as well as reduced resources and energy needs. On the contrary, large data windows are normally considered for the recognition of complex activities. In this work, we present an extensive study to fairly characterize the windowing procedure, to determine its impact within the activity recognition process and to help clarify some of the habitual assumptions made during the recognition system design. To that end, some of the most widely used activity recognition procedures are evaluated for a wide range of window sizes and activities. From the evaluation, the interval 1–2 s proves to provide the best trade-off between recognition speed and accuracy. The study, specifically intended for on-body activity recognition systems, further provides designers with a set of guidelines devised to facilitate the system definition and configuration according to the particular application requirements and target activities.

  2. Exploring human papillomavirus vaccination refusal among ethnic minorities in England: A comparative qualitative study.

    Science.gov (United States)

    Forster, Alice S; Rockliffe, Lauren; Marlow, Laura A V; Bedford, Helen; McBride, Emily; Waller, Jo

    2017-09-01

    In England, uptake of human papillomavirus (HPV) vaccination to prevent HPV-related cancer is lower among girls from ethnic minority backgrounds. We aimed to explore the factors that prevented ethnic minority parents from vaccinating, compared to White British nonvaccinating parents and vaccinating ethnic minority parents. Interviews with 33 parents (n = 14 ethnic minority non-vaccinating, n = 10 White British nonvaccinating, and n = 9 ethnic minority vaccinating) explored parents' reasons for giving or withholding consent for HPV vaccination. Data were analysed using Framework Analysis. Concerns about the vaccine were raised by all nonvaccinating ethnic minority parents, and they wanted information to address these concerns. External and internal influences affected parents' decisions, as well as parents' perceptions that HPV could be prevented using means other than vaccination. Reasons were not always exclusive to nonvaccinating ethnic minority parents, although some were, including a preference for abstinence from sex before marriage. Only ethnic minority parents wanted information provided via workshops. Ethnic differences in HPV vaccination uptake may be partly explained by concerns that were only reported by parents from some ethnic groups. Interventions to improve uptake may need to tackle difficult topics like abstinence from sex before marriage, and use a targeted format. © 2017 The Authors. Psycho-Oncology Published by John Wiley & Sons Ltd.

  3. Towards human exploration of space: The THESEUS review series on immunology research priorities.

    Science.gov (United States)

    Frippiat, Jean-Pol; Crucian, Brian E; de Quervain, Dominique J-F; Grimm, Daniela; Montano, Nicola; Praun, Siegfried; Roozendaal, Benno; Schelling, Gustav; Thiel, Manfred; Ullrich, Oliver; Choukèr, Alexander

    2016-01-01

    Dysregulation of the immune system occurs during spaceflight and may represent a crew health risk during exploration missions because astronauts are challenged by many stressors. Therefore, it is crucial to understand the biology of immune modulation under spaceflight conditions in order to be able to maintain immune homeostasis under such challenges. In the framework of the THESEUS project whose aim was to develop an integrated life sciences research roadmap regarding human space exploration, experts working in the field of space immunology, and related disciplines, established a questionnaire sent to scientists around the world. From the review of collected answers, they deduced a list of key issues and provided several recommendations such as a maximal exploitation of currently available resources on Earth and in space, and to increase increments duration for some ISS crew members to 12 months or longer. These recommendations should contribute to improve our knowledge about spaceflight effects on the immune system and the development of countermeasures that, beyond astronauts, could have a societal impact.

  4. Development of NASA's Small Fission Power System for Science and Human Exploration

    Science.gov (United States)

    Gibson, Marc A.; Mason, Lee S.; Bowman, Cheryl L.; Poston, David I.; McClure, Patrick R.; Creasy, John; Robinson, Chris

    2015-01-01

    Exploration of our solar system has brought many exciting challenges to our nations scientific and engineering community over the past several decades. As we expand our visions to explore new, more challenging destinations, we must also expand our technology base to support these new missions. NASAs Space Technology Mission Directorate is tasked with developing these technologies for future mission infusion and continues to seek answers to many existing technology gaps. One such technology gap is related to compact power systems (1 kWe) that provide abundant power for several years where solar energy is unavailable or inadequate. Below 1 kWe, Radioisotope Power Systems have been the workhorse for NASA and will continue to be used for lower power applications similar to the successful missions of Voyager, Ulysses, New Horizons, Cassini, and Curiosity. Above 1 kWe, fission power systems become an attractive technology offering a scalable modular design of the reactor, shield, power conversion, and heat transport subsystems. Near term emphasis has been placed in the 1-10kWe range that lies outside realistic radioisotope power levels and fills a promising technology gap capable of enabling both science and human exploration missions. History has shown that development of space reactors is technically, politically, and financially challenging and requires a new approach to their design and development. A small team of NASA and DOE experts are providing a solution to these enabling FPS technologies starting with the lowest power and most cost effective reactor series named Kilopower that is scalable from approximately 1-10 kWe.

  5. Exploring the relationship between outdoor recreation activities, community participation, and environmental attitudes

    Science.gov (United States)

    Lindsey Barker; Chad Dawson

    2012-01-01

    The relationship between environmental attitudes (EA) and environmentally responsible behavior (ERB) has been the focus of several studies in environmental psychology and recreation research. The purpose of this study was to explore the relationship between EAs and ERBs at both a general level and at an activity-specific level using a 2009 survey of motorized...

  6. Participation Patterns of Korean Adolescents in School-Based Career Exploration Activities

    Science.gov (United States)

    Rojewski, Jay W.; Lee, In Heok; Hill, Roger B.

    2014-01-01

    Variations in the school-based career exploration activities of Korean high school students were examined. Data represented 5,227 Korean adolescents in Grade 11 contained in the Korean Education Longitudinal Study of 2005, a nationally representative longitudinal database administered by the Korean Educational Development Institute. Latent class…

  7. Flipped Classroom with Problem Based Activities: Exploring Self-Regulated Learning in a Programming Language Course

    Science.gov (United States)

    Çakiroglu, Ünal; Öztürk, Mücahit

    2017-01-01

    This study intended to explore the development of self-regulation in a flipped classroom setting. Problem based learning activities were carried out in flipped classrooms to promote self-regulation. A total of 30 undergraduate students from Mechatronic department participated in the study. Self-regulation skills were discussed through students'…

  8. Effects of oil exploration on the anatomy and antimicrobial activity of ...

    African Journals Online (AJOL)

    Nigeria flares much natural gas associated with oil exploration like many other countries of the world. A major problem of gas flaring is the release of large amounts of methane, which has the potential to affect medicinal plants. The effects of gas flaring on the anatomy and antimicrobial activities of Annona muricata, used by ...

  9. Uncovering Students' Environmental Identity: An Exploration of Activities in an Environmental Science Course

    Science.gov (United States)

    Blatt, Erica

    2014-01-01

    This study at a public high school in the Northeastern United States explores how students' environmental identities are affected by various activities in an Environmental Science course. Data was collected as part of an ethnographic study involving an Environmental Science teacher and her tenth-twelfth grade students. The results focus on…

  10. Social Inequalities in Body Weight and Physical Activity: Exploring the Role of Fitness Centers

    Science.gov (United States)

    McLaren, Lindsay; Rock, Melanie J.; McElgunn, Jamie

    2012-01-01

    Fitness centers are a viable option for physical activity, particularly in climates with significant weather variation. Due to variation in economic and social expressions of exclusivity, fitness centers may have some relation to social inequalities in physical inactivity and related health outcomes; thus, our objective was to explore this…

  11. Exploring Meaning of Active Learning with Millennial Nursing Students: A Phenomenological Study

    Science.gov (United States)

    Szoka, Amy

    2017-01-01

    The purpose of this interpretive, phenomenological study was to explore and understand how millennial nursing students perceived their lived experiences of being active learners in an associate degree program and how it affected student learning outcomes and/or program satisfaction. The research questions guiding this study were based on…

  12. Activating Metaphors: Exploring the Embodied Nature of Metaphorical Mapping in Political Discourse

    Science.gov (United States)

    Giovanelli, Marcello

    2016-01-01

    Metaphor is generally understood as the process of understanding one thing in terms of another. The activity described here is designed to make use of the principles of embodied cognition and meaning, and specifically the embodied nature of metaphor, to explore political discourse and communication. With high-school junior or senior students in…

  13. HuAc: Human Activity Recognition Using Crowdsourced WiFi Signals and Skeleton Data

    Directory of Open Access Journals (Sweden)

    Linlin Guo

    2018-01-01

    Full Text Available The joint of WiFi-based and vision-based human activity recognition has attracted increasing attention in the human-computer interaction, smart home, and security monitoring fields. We propose HuAc, the combination of WiFi-based and Kinect-based activity recognition system, to sense human activity in an indoor environment with occlusion, weak light, and different perspectives. We first construct a WiFi-based activity recognition dataset named WiAR to provide a benchmark for WiFi-based activity recognition. Then, we design a mechanism of subcarrier selection according to the sensitivity of subcarriers to human activities. Moreover, we optimize the spatial relationship of adjacent skeleton joints and draw out a corresponding relationship between CSI and skeleton-based activity recognition. Finally, we explore the fusion information of CSI and crowdsourced skeleton joints to achieve the robustness of human activity recognition. We implemented HuAc using commercial WiFi devices and evaluated it in three kinds of scenarios. Our results show that HuAc achieves an average accuracy of greater than 93% using WiAR dataset.

  14. Exploring the facilitators and barriers to engagement in physical activity for people with multiple sclerosis.

    Science.gov (United States)

    Kayes, Nicola M; McPherson, Kathryn M; Schluter, Philip; Taylor, Denise; Leete, Marta; Kolt, Gregory S

    2011-01-01

    To explore the relationship that cognitive behavioural and other previously identified variables have with physical activity engagement in people with multiple sclerosis (MS). This study adopted a cross-sectional questionnaire design. Participants were 282 individuals with MS. Outcome measures included the Physical Activity Disability Survey--Revised, Cognitive and Behavioural Responses to Symptoms Questionnaire, Barriers to Health Promoting Activities for Disabled Persons Scale, Multiple Sclerosis Self-efficacy Scale, Self-Efficacy for Chronic Diseases Scales and Chalder Fatigue Questionnaire. Multivariable stepwise regression analyses found that greater self-efficacy, greater reported mental fatigue and lower number of perceived barriers to physical activity accounted for a significant proportion of variance in physical activity behaviour, over that accounted for by illness-related variables. Although fear-avoidance beliefs accounted for a significant proportion of variance in the initial analyses, its effect was explained by other factors in the final multivariable analyses. Self-efficacy, mental fatigue and perceived barriers to physical activity are potentially modifiable variables which could be incorporated into interventions designed to improve physical activity engagement. Future research should explore whether a measurement tool tailored to capture beliefs about physical activity identified by people with MS would better predict participation in physical activity.

  15. A testbed to explore the optimal electrical stimulation parameters for suppressing inter-ictal spikes in human hippocampal slices.

    Science.gov (United States)

    Min-Chi Hsiao; Pen-Ning Yu; Dong Song; Liu, Charles Y; Heck, Christi N; Millett, David; Berger, Theodore W

    2014-01-01

    New interventions using neuromodulatory devices such as vagus nerve stimulation, deep brain stimulation and responsive neurostimulation are available or under study for the treatment of refractory epilepsy. Since the actual mechanisms of the onset and termination of the seizure are still unclear, most researchers or clinicians determine the optimal stimulation parameters through trial-and-error procedures. It is necessary to further explore what types of electrical stimulation parameters (these may include stimulation frequency, amplitude, duration, interval pattern, and location) constitute a set of optimal stimulation paradigms to suppress seizures. In a previous study, we developed an in vitro epilepsy model using hippocampal slices from patients suffering from mesial temporal lobe epilepsy. Using a planar multi-electrode array system, inter-ictal activity from human hippocampal slices was consistently recorded. In this study, we have further transferred this in vitro seizure model to a testbed for exploring the possible neurostimulation paradigms to inhibit inter-ictal spikes. The methodology used to collect the electrophysiological data, the approach to apply different electrical stimulation parameters to the slices are provided in this paper. The results show that this experimental testbed will provide a platform for testing the optimal stimulation parameters of seizure cessation. We expect this testbed will expedite the process for identifying the most effective parameters, and may ultimately be used to guide programming of new stimulating paradigms for neuromodulatory devices.

  16. Fuel Cell Development for NASA's Human Exploration Program: Benchmarking with "The Hydrogen Economy"

    Science.gov (United States)

    Scott, John H.

    2007-01-01

    The theoretically high efficiency and low temperature operation of hydrogen-oxygen fuel cells has motivated them to be the subject of much study since their invention in the 19th Century, but their relatively high life cycle costs kept them as a "solution in search of a problem" for many years. The first problem for which fuel cells presented a truly cost effective solution was that of providing a power source for NASA's human spaceflight vehicles in the 1960 s. NASA thus invested, and continues to invest, in the development of fuel cell power plants for this application. This development program continues to place its highest priorities on requirements for minimum system mass and maximum durability and reliability. These priorities drive fuel cell power plant design decisions at all levels, even that of catalyst support. However, since the mid-1990's, prospective environmental regulations have driven increased governmental and industrial interest in "green power" and the "Hydrogen Economy." This has in turn stimulated greatly increased investment in fuel cell development for a variety of commercial applications. This investment is bringing about notable advances in fuel cell technology, but, as these development efforts place their highest priority on requirements for minimum life cycle cost and field safety, these advances are yielding design solutions quite different at almost every level from those needed for spacecraft applications. This environment thus presents both opportunities and challenges for NASA's Human Exploration Program

  17. Overview of Intelligent Power Controller Development for Human Deep Space Exploration

    Science.gov (United States)

    Soeder, James F.; Dever, Timothy P.; McNelis, Anne M.; Beach, Raymond F.; Trase, Larry M.; May, Ryan D.

    2014-01-01

    Intelligent or autonomous control of an entire spacecraft is a major technology that must be developed to enable NASA to meet its human exploration goals. NASA's current long term human space platform, the International Space Station, is in low Earth orbit with almost continuous communication with the ground based mission control. This permits the near real-time control by the ground of all of the core systems including power. As NASA moves beyond low Earth orbit, the issues of communication time-lag and lack of communication bandwidth beyond geosynchronous orbit does not permit this type of operation. This paper presents the work currently ongoing at NASA to develop an architecture for an autonomous power control system as well as the effort to assemble that controller into the framework of the vehicle mission manager and other subsystem controllers to enable autonomous control of the complete spacecraft. Due to the common problems faced in both space power systems and terrestrial power system, the potential for spin-off applications of this technology for use in micro-grids located at the edge or user end of terrestrial power grids for peak power accommodation and reliability are described.

  18. Activation of human immunodeficiency virus by radiation

    International Nuclear Information System (INIS)

    Beer, J.Z.; Zmudzka, B.Z.

    1991-01-01

    It was recently demonstrated that ultraviolet radiation (UVR) can induce the HIV promoter as well as activate the complete virus in cultured cells (Valerie et al., 1988). This and subsequent observations, reviewed in this article, suggest a possibility that radiation exposure may accelerate development of AIDS in HIV-infected individuals. They also indicate that studies on HIV activation by stressors, including radiation, may advance our understanding of some phenomena that follow HIV infection. (author)

  19. Robust, synergistic regulation of human gene expression using TALE activators.

    Science.gov (United States)

    Maeder, Morgan L; Linder, Samantha J; Reyon, Deepak; Angstman, James F; Fu, Yanfang; Sander, Jeffry D; Joung, J Keith

    2013-03-01

    Artificial activators designed using transcription activator-like effector (TALE) technology have broad utility, but previous studies suggest that these monomeric proteins often exhibit low activities. Here we demonstrate that TALE activators can robustly function individually or in synergistic combinations to increase expression of endogenous human genes over wide dynamic ranges. These findings will encourage applications of TALE activators for research and therapy, and guide design of monomeric TALE-based fusion proteins.

  20. Barrier-beliefs about physical activity in active and inactive adults : an explorative study

    NARCIS (Netherlands)

    Bouma, Adrie

    2018-01-01

    Objectives: Perceived barriers are often a reason why people do not start physical activity or relapse to inactivity. From a psychological perspective, barriers can be seen as beliefs about what is obstructing people’s behavior. To understand inactivity and relapse from physical activity, this study

  1. Exploring the role of physical activity for people diagnosed with serious mental illness in Ireland.

    Science.gov (United States)

    Cullen, C; McCann, E

    2015-02-01

    The aim of the study was to elicit the views and opinions of people diagnosed with serious mental illness in relation to physical activity. Ten people who were attending a community mental health centre participated in semi-structured interviews. The main results showed that participants found physical activity beneficial in terms of psychological and social well-being and perceived clear gains in relation to recovery and quality of life. Physical activity should be routinely included in plans of care and mental health policy guidelines globally should contain physical activity as a key component. Mental health policy guidelines globally should contain physical activity as a key component. The aim of the current study was to explore the subjective experiences of people diagnosed with serious mental illness (SMI) in relation to physical activity. The study was conducted using a qualitative exploratory descriptive approach. The participants (n = 10), who were outpatients attending a day centre, were interviewed to elicit their views and opinions about physical activity. The data were thematically analysed using a recognized framework. The main themes that emerged included physical activity as a meaningful activity, physical activity as a mental activity, quality of life and recovery, and perceived challenges to physical activity. The unique perspectives of service users provides fresh insights on the topic and the findings support the justification for the inclusion of physical activity in plans of care and to be contained in global mental health policy directives. © 2014 John Wiley & Sons Ltd.

  2. Using human error theory to explore the supply of non-prescription medicines from community pharmacies.

    Science.gov (United States)

    Watson, M C; Bond, C M; Johnston, M; Mearns, K

    2006-08-01

    The importance of theory in underpinning interventions to promote effective professional practice is gaining recognition. The Medical Research Council framework for complex interventions has assisted in promoting awareness and adoption of theory into study design. Human error theory has previously been used by high risk industries but its relevance to healthcare settings and patient safety requires further investigation. This study used this theory as a framework to explore non-prescription medicine supply from community pharmacies. The relevance to other healthcare settings and behaviours is discussed. A 25% random sample was made of 364 observed consultations for non-prescription medicines. Each of the 91 consultations was assessed by two groups: a consensus group (stage 1) to identify common problems with the consultation process, and an expert group (stages 2 and 3) to apply human error theory to these consultations. Paired assessors (most of whom were pharmacists) categorised the perceived problems occurring in each consultation (stage 1). During stage 2 paired assessors from an expert group (comprising patient safety experts, community pharmacists and psychologists) considered whether each consultation was compliant with professional guidelines for the supply of pharmacy medicines. Each non-compliant consultation identified during stage 2 was then categorised as a slip/lapse, mistake, or violation using human error theory (stage 3). During stage 1 most consultations (n = 75, 83%) were deemed deficient in information exchange. At stage 2, paired assessors varied in attributing non-compliance to specific error types. Where agreement was achieved, the error type most often selected was "violation" (n = 27, 51.9%, stage 3). Consultations involving product requests were less likely to be guideline compliant than symptom presentations (OR 0.30, 95% CI 0.10 to 0.95, p = 0.05). The large proportion of consultations classified as violations suggests that either

  3. Finding Near-Earth Asteroid (NEA) Destinations for Human Exploration: Implications for Astrobiology

    Science.gov (United States)

    Landis, Rob; Abell, Paul; Barbee, Brent; Johnson, Lindley

    2012-01-01

    The current number of known potential NEA targets for HSF is limited to those objects whose orbital characteristics are similar to that of the Earth. This is due to the projected capabilities of the exploration systems currently under consideration and development at NASA. However, NEAs with such orbital characteristics often have viewing geometries that place them at low solar elongations and thus are difficult to detect from the vicinity of Earth. While ongoing ground-based surveys and data archives maintained by the NEO Program Observation Program Office and the Minor Planet Center (MPC) have provided a solid basis upon which to build, a more complete catalog of the NEO population is required to inform a robust and sustainable HSF exploration program. Since all the present NEO observing assets are currently confined to the vicinity of the Earth, additional effort must be made to provide capabilities for detection of additional HSF targets via assets beyond Earth orbit. A space-based NEO survey telescope located beyond the vicinity of the Earth, has considerable implications for planetary science and astrobiology. Such a telescope will provide foundational knowledge of our Solar System small body population and detect targets of interest for both the HSF and scientific communities. Data from this asset will yield basic characterization data on the NEOs observed (i.e., albedo, size determination, potential for volatiles and organics, etc.) and help down select targets for future HSF missions. Ideally, the most attractive targets from both HSF and astrobiology perspectives are those NEAs that may contain organic and volatile materials, and which could be effectively sampled at a variety of locations and depths. Presented here is an overview of four space-based survey concepts; any one of which after just a few years of operation will discover many highly accessible NEO targets suitable for robotic and human exploration. Such a space-based survey mission will reveal

  4. ActivityNet: A Large-Scale Video Benchmark for Human Activity Understanding

    KAUST Repository

    Heilbron, Fabian Caba

    2015-06-02

    In spite of many dataset efforts for human action recognition, current computer vision algorithms are still severely limited in terms of the variability and complexity of the actions that they can recognize. This is in part due to the simplicity of current benchmarks, which mostly focus on simple actions and movements occurring on manually trimmed videos. In this paper we introduce ActivityNet, a new largescale video benchmark for human activity understanding. Our benchmark aims at covering a wide range of complex human activities that are of interest to people in their daily living. In its current version, ActivityNet provides samples from 203 activity classes with an average of 137 untrimmed videos per class and 1.41 activity instances per video, for a total of 849 video hours. We illustrate three scenarios in which ActivityNet can be used to compare algorithms for human activity understanding: untrimmed video classification, trimmed activity classification and activity detection.

  5. ActivityNet: A Large-Scale Video Benchmark for Human Activity Understanding

    KAUST Repository

    Heilbron, Fabian Caba; Castillo, Victor; Ghanem, Bernard; Niebles, Juan Carlos

    2015-01-01

    In spite of many dataset efforts for human action recognition, current computer vision algorithms are still severely limited in terms of the variability and complexity of the actions that they can recognize. This is in part due to the simplicity of current benchmarks, which mostly focus on simple actions and movements occurring on manually trimmed videos. In this paper we introduce ActivityNet, a new largescale video benchmark for human activity understanding. Our benchmark aims at covering a wide range of complex human activities that are of interest to people in their daily living. In its current version, ActivityNet provides samples from 203 activity classes with an average of 137 untrimmed videos per class and 1.41 activity instances per video, for a total of 849 video hours. We illustrate three scenarios in which ActivityNet can be used to compare algorithms for human activity understanding: untrimmed video classification, trimmed activity classification and activity detection.

  6. Human and Mouse Eosinophils Have Antiviral Activity against Parainfluenza Virus.

    Science.gov (United States)

    Drake, Matthew G; Bivins-Smith, Elizabeth R; Proskocil, Becky J; Nie, Zhenying; Scott, Gregory D; Lee, James J; Lee, Nancy A; Fryer, Allison D; Jacoby, David B

    2016-09-01

    Respiratory viruses cause asthma exacerbations. Because eosinophils are the prominent leukocytes in the airways of 60-70% of patients with asthma, we evaluated the effects of eosinophils on a common respiratory virus, parainfluenza 1, in the lung. Eosinophils recruited to the airways of wild-type mice after ovalbumin sensitization and challenge significantly decreased parainfluenza virus RNA in the lungs 4 days after infection compared with nonsensitized animals. This antiviral effect was also seen in IL-5 transgenic mice with an abundance of airway eosinophils (NJ.1726) but was lost in transgenic eosinophil-deficient mice (PHIL) and in IL-5 transgenic mice crossed with eosinophil-deficient mice (NJ.1726-PHIL). Loss of the eosinophil granule protein eosinophil peroxidase, using eosinophil peroxidase-deficient transgenic mice, did not reduce eosinophils' antiviral effect. Eosinophil antiviral mechanisms were also explored in vitro. Isolated human eosinophils significantly reduced parainfluenza virus titers. This effect did not involve degradation of viral RNA by eosinophil granule RNases. However, eosinophils treated with a nitric oxide synthase inhibitor lost their antiviral activity, suggesting eosinophils attenuate viral infectivity through production of nitric oxide. Consequently, eosinophil nitric oxide production was measured with an intracellular fluorescent probe. Eosinophils produced nitric oxide in response to virus and to a synthetic agonist of the virus-sensing innate immune receptor, Toll-like receptor (TLR) 7. IFNγ increased expression of eosinophil TLR7 and potentiated TLR7-induced nitric oxide production. These results suggest that eosinophils promote viral clearance in the lung and contribute to innate immune responses against respiratory virus infections in humans.

  7. Exploring sets of molecules from patents and relationships to other active compounds in chemical space networks

    Science.gov (United States)

    Kunimoto, Ryo; Bajorath, Jürgen

    2017-09-01

    Patents from medicinal chemistry represent a rich source of novel compounds and activity data that appear only infrequently in the scientific literature. Moreover, patent information provides a primary focal point for drug discovery. Accordingly, text mining and image extraction approaches have become hot topics in patent analysis and repositories of patent data are being established. In this work, we have generated network representations using alternative similarity measures to systematically compare molecules from patents with other bioactive compounds, visualize similarity relationships, explore the chemical neighbourhood of patent molecules, and identify closely related compounds with different activities. The design of network representations that combine patent molecules and other bioactive compounds and view patent information in the context of current bioactive chemical space aids in the analysis of patents and further extends the use of molecular networks to explore structure-activity relationships.

  8. Human activity and climate variability project - annual report 2002

    International Nuclear Information System (INIS)

    Chambers, S.; Harle, K.J.; Sharmeen, S.; Zahorowski, W.; Cohen, D.; Heijnis, H.; Henderson-Sellers, A

    2002-01-01

    Work is well underway on identifying the spatial and temporal extent, direction and range of trace element transport across Tasmania through analysis of lake sediments; A follow up investigation of sedimentation and pollution in the Nattai River catchment following the devastating 2001 bushfires in the region has been completed; The project has been extended to include investigations of evidence of human impacts in the highly sensitive and ecologically important Great Lakes of coastal NSW. This has involved the expansion of our collaboration to include Geoscience Australia; Contributions have been made to the IGBP HITE project. Further contributions will be made as the evidence gathered is drawn together and interpreted; Over the coming year, focus will be placed on completion of the investigation of the extent of aerial transport of trace elements across Tasmania over the last 200 years as well as evidence for human activity and impacts on the Great Lakes region of NSW. Further investigation of potential climate signals from sites in northern Australia will also be made. The first 12 months of data for all ACE-Asia radon and fine particle sites is now available with preliminary analyses performed; The seasonal variability of background radon concentration at each of the radon monitoring sites has been characterised for the available data; Major components related to industrial pollution and soil sources in China have been identified and quantified; Regional and seasonal variations and trends in aerosol constituents have been measured and compared across more than 2.8Mk 2 of sampling area; The Hok Tsui and Kosan detectors were visited for general maintenance and recalibration; A grant application to the APN has been submitted in support of regional inventory analyses based on radon time series; Progress on the processing and interpretation of radon data was presented at the Cape Grim Science Meeting (6-7 February 2002) and the 7th Biennial SPERA Conference on

  9. Human activity and climate variability project - annual report 2002

    Energy Technology Data Exchange (ETDEWEB)

    Chambers, S; Harle, K J; Sharmeen, S; Zahorowski, W; Cohen, D; Heijnis, H; Henderson-Sellers, A [Australian Nuclear Science and Technology Organisation, Menai, NSW (Australia)

    2002-07-01

    Work is well underway on identifying the spatial and temporal extent, direction and range of trace element transport across Tasmania through analysis of lake sediments; A follow up investigation of sedimentation and pollution in the Nattai River catchment following the devastating 2001 bushfires in the region has been completed; The project has been extended to include investigations of evidence of human impacts in the highly sensitive and ecologically important Great Lakes of coastal NSW. This has involved the expansion of our collaboration to include Geoscience Australia; Contributions have been made to the IGBP HITE project. Further contributions will be made as the evidence gathered is drawn together and interpreted; Over the coming year, focus will be placed on completion of the investigation of the extent of aerial transport of trace elements across Tasmania over the last 200 years as well as evidence for human activity and impacts on the Great Lakes region of NSW. Further investigation of potential climate signals from sites in northern Australia will also be made. The first 12 months of data for all ACE-Asia radon and fine particle sites is now available with preliminary analyses performed; The seasonal variability of background radon concentration at each of the radon monitoring sites has been characterised for the available data; Major components related to industrial pollution and soil sources in China have been identified and quantified; Regional and seasonal variations and trends in aerosol constituents have been measured and compared across more than 2.8Mk{sup 2} of sampling area; The Hok Tsui and Kosan detectors were visited for general maintenance and recalibration; A grant application to the APN has been submitted in support of regional inventory analyses based on radon time series; Progress on the processing and interpretation of radon data was presented at the Cape Grim Science Meeting (6-7 February 2002) and the 7th Biennial SPERA Conference on

  10. Efficient Active Sensing with Categorized Further Explorations for a Home Behavior-Monitoring Robot

    Directory of Open Access Journals (Sweden)

    Wenwei Yu

    2017-01-01

    Full Text Available Mobile robotics is a potential solution to home behavior monitoring for the elderly. For a mobile robot in the real world, there are several types of uncertainties for its perceptions, such as the ambiguity between a target object and the surrounding objects and occlusions by furniture. The problem could be more serious for a home behavior-monitoring system, which aims to accurately recognize the activity of a target person, in spite of these uncertainties. It detects irregularities and categorizes situations requiring further explorations, which strategically maximize the information needed for activity recognition while minimizing the costs. Two schemes of active sensing, based on two irregularity detections, namely, heuristic-based and template-matching-based irregularity detections, were implemented and examined for body contour-based activity recognition. Their time cost and accuracy in activity recognition were evaluated through experiments in both a controlled scenario and a home living scenario. Experiment results showed that the categorized further explorations guided the robot system to sense the target person actively. As a result, with the proposed approach, the robot system has achieved higher accuracy of activity recognition.

  11. Differential effects of human activity on Hawaiian spinner dolphins in their resting bays

    Directory of Open Access Journals (Sweden)

    Heather L. Heenehan

    2017-04-01

    vessel in Bay 2 when compared to Bay 1, a bay with dolphin-focused activities. We hypothesize it is not the magnitude of the activity but the focus of the activity that matters and suggest that the effect of human activity on spinner dolphin acoustic behavior should be explored in future studies. These results have implications for designing future studies as well as for ongoing efforts to protect Hawaiian spinner dolphins in their resting bays.

  12. Coordination of International Risk-Reduction Investigations by the Multilateral Human Research Panel for Exploration

    Science.gov (United States)

    Charles, John B.; Bogomolov, Valery V.

    2015-01-01

    Effective use of the unique capabilities of the International Space Station (ISS) for risk reduction on future deep space missions involves preliminary work in analog environments to identify and evaluate the most promising techniques, interventions and treatments. This entails a consolidated multinational approach to biomedical research both on ISS and in ground analogs. The Multilateral Human Research Panel for Exploration (MHRPE) was chartered by the five ISS partners to recommend the best combination of partner investigations on ISS for risk reduction in the relatively short time available for ISS utilization. MHRPE will also make recommendations to funding agencies for appropriate preparatory analog work. In 2011, NASA's Human Research Program (HRP) and the Institute of Biomedical Problems (IBMP) of the Russian Academy of Science, acting for MHRPE, developed a joint US-Russian biomedical program for the 2015 one-year ISS mission (1YM) of American and Russian crewmembers. This was to evaluate the possibilities for multilateral research on ISS. An overlapping list of 16 HRP, 9 IBMP, 3 Japanese, 3 European and 1 Canadian investigations were selected to address risk-reduction goals in 7 categories: Functional Performance, Behavioral Health, Visual Impairment, Metabolism, Physical Capacity, Microbial and Human Factors. MHRPE intends to build on this bilateral foundation to recommend more fully-integrated multilateral investigations on future ISS missions commencing after the 1YM. MHRPE has also endorsed an on-going program of coordinated research on 6-month, one-year and 6-week missions ISS expeditions that is now under consideration by ISS managers. Preparatory work for these missions will require coordinated and collaborative campaigns especially in the psychological and psychosocial areas using analog isolation facilities in Houston, Köln and Moscow, and possibly elsewhere. The multilateral Human Analogs research working group (HANA) is the focal point of those

  13. Functional assessment of human enhancer activities using whole-genome STARR-sequencing.

    Science.gov (United States)

    Liu, Yuwen; Yu, Shan; Dhiman, Vineet K; Brunetti, Tonya; Eckart, Heather; White, Kevin P

    2017-11-20

    Genome-wide quantification of enhancer activity in the human genome has proven to be a challenging problem. Recent efforts have led to the development of powerful tools for enhancer quantification. However, because of genome size and complexity, these tools have yet to be applied to the whole human genome.  In the current study, we use a human prostate cancer cell line, LNCaP as a model to perform whole human genome STARR-seq (WHG-STARR-seq) to reliably obtain an assessment of enhancer activity. This approach builds upon previously developed STARR-seq in the fly genome and CapSTARR-seq techniques in targeted human genomic regions. With an improved library preparation strategy, our approach greatly increases the library complexity per unit of starting material, which makes it feasible and cost-effective to explore the landscape of regulatory activity in the much larger human genome. In addition to our ability to identify active, accessible enhancers located in open chromatin regions, we can also detect sequences with the potential for enhancer activity that are located in inaccessible, closed chromatin regions. When treated with the histone deacetylase inhibitor, Trichostatin A, genes nearby this latter class of enhancers are up-regulated, demonstrating the potential for endogenous functionality of these regulatory elements. WHG-STARR-seq provides an improved approach to current pipelines for analysis of high complexity genomes to gain a better understanding of the intricacies of transcriptional regulation.

  14. Exploring beliefs around physical activity among older adults in rural Canada.

    Science.gov (United States)

    Schmidt, Laurie; Rempel, Gwen; Murray, Terra C; McHugh, Tara-Leigh; Vallance, Jeff K

    2016-01-01

    As physical activity can improve health and reduce the risk of chronic disease, it is important to understand the contributing factors to physical activity engagement among older adults, particularly those living in rural communities to assist in remaining active and healthy as long as possible. The purpose of this study was to gain a deeper understanding of the socio-ecological factors that influence or contribute to physical activity among rural-dwelling older adults in rural Saskatchewan, Canada. This qualitative description explored the perceptions of physical activity among older adults living in two rural communities in the Canadian province of Saskatchewan. Semi-structured interviews were conducted with 10 adults aged 69-94. Using content analysis techniques, transcribed interview data were coded and categorized. Participants identified socio-ecological elements facilitating physical activity such as improved health, independence, and mobility as well as social cohesion and having opportunities for physical activity. The most common perceived environmental barrier to engaging in physical activity was the fear of falling, particularly on the ice during the winter months. Participants also cited adverse weather conditions, aging (e.g., arthritis), and family members (e.g., encouraged to "take it easy") as barriers to physical activity. Hearing directly from older adults who reside in rural Saskatchewan was determined to have the potential to improve awareness of physical activity in rural communities to support the implementation of programs and practices that will facilitate active lifestyles for older adults.

  15. Exploring beliefs around physical activity among older adults in rural Canada

    Directory of Open Access Journals (Sweden)

    Laurie Schmidt

    2016-11-01

    Full Text Available Objective: As physical activity can improve health and reduce the risk of chronic disease, it is important to understand the contributing factors to physical activity engagement among older adults, particularly those living in rural communities to assist in remaining active and healthy as long as possible. The purpose of this study was to gain a deeper understanding of the socio-ecological factors that influence or contribute to physical activity among rural-dwelling older adults in rural Saskatchewan, Canada. Methods: This qualitative description explored the perceptions of physical activity among older adults living in two rural communities in the Canadian province of Saskatchewan. Semi-structured interviews were conducted with 10 adults aged 69–94. Using content analysis techniques, transcribed interview data were coded and categorized. Results: Participants identified socio-ecological elements facilitating physical activity such as improved health, independence, and mobility as well as social cohesion and having opportunities for physical activity. The most common perceived environmental barrier to engaging in physical activity was the fear of falling, particularly on the ice during the winter months. Participants also cited adverse weather conditions, aging (e.g., arthritis, and family members (e.g., encouraged to “take it easy” as barriers to physical activity. Conclusion: Hearing directly from older adults who reside in rural Saskatchewan was determined to have the potential to improve awareness of physical activity in rural communities to support the implementation of programs and practices that will facilitate active lifestyles for older adults.

  16. Dietary methanol regulates human gene activity.

    Directory of Open Access Journals (Sweden)

    Anastasia V Shindyapina

    Full Text Available Methanol (MeOH is considered to be a poison in humans because of the alcohol dehydrogenase (ADH-mediated conversion of MeOH to formaldehyde (FA, which is toxic. Our recent genome-wide analysis of the mouse brain demonstrated that an increase in endogenous MeOH after ADH inhibition led to a significant increase in the plasma MeOH concentration and a modification of mRNA synthesis. These findings suggest endogenous MeOH involvement in homeostasis regulation by controlling mRNA levels. Here, we demonstrate directly that study volunteers displayed increasing concentrations of MeOH and FA in their blood plasma when consuming citrus pectin, ethanol and red wine. A microarray analysis of white blood cells (WBC from volunteers after pectin intake showed various responses for 30 significantly differentially regulated mRNAs, most of which were somehow involved in the pathogenesis of Alzheimer's disease (AD. There was also a decreased synthesis of hemoglobin mRNA, HBA and HBB, the presence of which in WBC RNA was not a result of red blood cells contamination because erythrocyte-specific marker genes were not significantly expressed. A qRT-PCR analysis of volunteer WBCs after pectin and red wine intake confirmed the complicated relationship between the plasma MeOH content and the mRNA accumulation of both genes that were previously identified, namely, GAPDH and SNX27, and genes revealed in this study, including MME, SORL1, DDIT4, HBA and HBB. We hypothesized that human plasma MeOH has an impact on the WBC mRNA levels of genes involved in cell signaling.

  17. Human activity spaces and plague risks in three contrasting ...

    African Journals Online (AJOL)

    Since 1980 plague has been a human threat in the Western Usambara Mountains in Tanzania. However, the spatial-temporal pattern of plague occurrence remains poorly understood. The main objective of this study was to gain understanding of human activity patterns in relation to spatial distribution of fleas in Lushoto ...

  18. Cytotoxic activities of Coriolus versicolor (Yunzhi) extracts on human ...

    African Journals Online (AJOL)

    SERVER

    2007-08-06

    Aug 6, 2007 ... four human liver cancer (7703, HepG2, 7721, PLC) and four human breast cancer (Bcap37, ZR75-30,. MCF-7, T-47D) cell lines ... Key words: Coriolus versicolor, fruit body, polysaccharide, anti-tumor. INTRODUCTION. Coriolus ... somewhat in structure, composition, and physiological activity. The present ...

  19. Human activity and the spread of Phytophthora ramorum

    Science.gov (United States)

    Hall J. Cushman; Michelle Cooper; Ross K. Meentemeyer; Shelly Benson

    2008-01-01

    Increasing numbers of studies are finding that humans can facilitate the spread of exotic plant species in protected wildlands. Hiking trails commonly serve as conduits for invaders and the number of exotic plant species occurring in protected areas is often correlated positively with visitation rates. Despite such evidence linking human activity to the spread of...

  20. Active Motor Training Has Long-term Effects on Infants’ Object Exploration

    Science.gov (United States)

    Wiesen, Sarah E.; Watkins, Rachel M.; Needham, Amy Work

    2016-01-01

    Long-term changes in infants’ behavior as a result of active motor training were studied. Thirty-two infants completed three visits to the laboratory. At the first visit, infants were 3 months old and completed an object exploration assessment. Then the experimenter demonstrated the motor training procedures appropriate for the infant’s experimental condition, and parents took home custom infant mittens (either sticky or non-sticky) and a bag of lightweight toys to practice with their infants. Over the course of the following 2 weeks, infants participated in 10 sessions of either active (sticky) or passive (non-sticky) mittens training at home with their parents. Infants who participated in active mittens training wore mittens with the palms covered in Velcro, allowing them to pick up and move around small toys. Infants who participated in passive mittens training wore non-sticky mittens, and their parents moved the toys through their visual fields on their behalf. After completing the training, infants returned to the lab for the second visit. At visit two, infants participated in another object exploration assessment as well as a reaching assessment. Parents returned the training materials to the lab at the second visit, and were told not to continue any specific training regimen from this point forward. Two months later, when infants were about 5.5 months of age, they returned to the lab for a third visit. At the third visit, infants completed the same two assessments as during the second visit. The results of this study indicate that infants who participated in active motor training engaged in more sophisticated object exploration when compared to infants who received passive training. These findings are consistent with others in the literature showing that active motor training at 3 months of age facilitates the processes of object exploration and engagement. The current results and others reveal that the effects of early experience can last long after

  1. Consistency in boldness, activity and exploration at different stages of life

    Science.gov (United States)

    2013-01-01

    Background Animals show consistent individual behavioural patterns over time and over situations. This phenomenon has been referred to as animal personality or behavioural syndromes. Little is known about consistency of animal personalities over entire life times. We investigated the repeatability of behaviour in common voles (Microtus arvalis) at different life stages, with different time intervals, and in different situations. Animals were tested using four behavioural tests in three experimental groups: 1. before and after maturation over three months, 2. twice as adults during one week, and 3. twice as adult animals over three months, which resembles a substantial part of their entire adult life span of several months. Results Different behaviours were correlated within and between tests and a cluster analysis showed three possible behavioural syndrome-axes, which we name boldness, exploration and activity. Activity and exploration behaviour in all tests was highly repeatable in adult animals tested over one week. In animals tested over maturation, exploration behaviour was consistent whereas activity was not. Voles that were tested as adults with a three-month interval showed the opposite pattern with stable activity but unstable exploration behaviour. Conclusions The consistency in behaviour over time suggests that common voles do express stable personality over short time. Over longer periods however, behaviour is more flexible and depending on life stage (i.e. tested before/after maturation or as adults) of the tested individual. Level of boldness or activity does not differ between tested groups and maintenance of variation in behavioural traits can therefore not be explained by expected future assets as reported in other studies. PMID:24314274

  2. When the World Changes in Your Hands: Similarity Ratings of Objects Morphing during Active Exploration

    Directory of Open Access Journals (Sweden)

    Haemy Lee

    2012-10-01

    Full Text Available View-based theories of object recognition posit that coherent object representations are formed by linking together successive views of an actively explored object. This linking process relies on the assumption that the object does not change during exploration. Here, we test how object representations might be influenced when the shape of the object changes slowly during exploration. In our experiment, participants rated the similarity of two novel, 3D objects, whose shape was parametrically defined. Seventeen participants explored each object for 10 sec on an iPad which afforded natural and efficient interaction. The experiment contained a baseline condition, in which two objects of varying parameter-differences were presented, and a morphing condition, in which the first of the two objects slowly morphed during active exploration, making the objects more similar. Interestingly, no participant was aware of this morphing manipulation. Comparing baseline and morph trials, however, we found significantly higher similarity ratings during morphing [F(1,16 = 84.79, p < .001]. Furthermore, correlations between similarity ratings and differences in object parameters were high for the baseline condition (r = −.64, with smaller parameter differences being perceived as more similar. Interestingly, in the morphing condition correlations were lower for parameter differences after the morph (r = −.22, but remained high for differences before (r = −.47 and during morphing (r = −.50. In conclusion, similarity ratings in the baseline condition captured the complex parameter space well. Although participants did not notice the changing shape, morphing did systematically bias the ratings. Interestingly, similarity judgments correlated better in the initial exploration phase, suggesting a capacity limit for view integration of complex shapes.

  3. Selective activation of neuromuscular compartments within the human trapezius muscle

    DEFF Research Database (Denmark)

    Holtermann, A; Roeleveld, K; Mork, P J

    2009-01-01

    of the human trapezius muscle can be independently activated by voluntary command, indicating neuromuscular compartmentalization of the trapezius muscle. The independent activation of the upper and lower subdivisions of the trapezius is in accordance with the selective innervation by the fine cranial and main...... branch of the accessory nerve to the upper and lower subdivisions. These findings provide new insight into motor control characteristics, learning possibilities, and function of the clinically relevant human trapezius muscle....

  4. Evolvable Mars Campaign Long Duration Habitation Strategies: Architectural Approaches to Enable Human Exploration Missions

    Science.gov (United States)

    Simon, Matthew A.; Toups, Larry; Howe, A. Scott; Wald, Samuel I.

    2015-01-01

    The Evolvable Mars Campaign (EMC) is the current NASA Mars mission planning effort which seeks to establish sustainable, realistic strategies to enable crewed Mars missions in the mid-2030s timeframe. The primary outcome of the Evolvable Mars Campaign is not to produce "The Plan" for sending humans to Mars, but instead its intent is to inform the Human Exploration and Operations Mission Directorate near-term key decisions and investment priorities to prepare for those types of missions. The FY'15 EMC effort focused upon analysis of integrated mission architectures to identify technically appealing transportation strategies, logistics build-up strategies, and vehicle designs for reaching and exploring Mars moons and Mars surface. As part of the development of this campaign, long duration habitats are required which are capable of supporting crew with limited resupply and crew abort during the Mars transit, Mars moons, and Mars surface segments of EMC missions. In particular, the EMC design team sought to design a single, affordable habitation system whose manufactured units could be outfitted uniquely for each of these missions and reused for multiple crewed missions. This habitat system must provide all of the functionality to safely support 4 crew for long durations while meeting mass and volume constraints for each of the mission segments set by the chosen transportation architecture and propulsion technologies. This paper describes several proposed long-duration habitation strategies to enable the Evolvable Mars Campaign through improvements in mass, cost, and reusability, and presents results of analysis to compare the options and identify promising solutions. The concepts investigated include several monolithic concepts: monolithic clean sheet designs, and concepts which leverage the co-manifested payload capability of NASA's Space Launch System (SLS) to deliver habitable elements within the Universal Payload Adaptor between the SLS upper stage and the Orion

  5. Barriers for recess physical activity: a gender specific qualitative focus group exploration

    DEFF Research Database (Denmark)

    Pawlowski, Charlotte Skau; Tjørnhøj-Thomsen, Tine; Schipperijn, Jasper

    Background: Many children, in particular girls, do not reach the recommended amount of daily physical activity. School recess provides an opportunity for both boys and girls to be physically active, but barriers to recess physical activity are not well understood. This study explores gender...... (53 boys) from fourth grade, with a mean age of 10.4 years. The focus groups included an open group discussion, go-along group interviews, and a gender segregated post-it note activity. A content analysis of the post-it notes was used to prioritize the children´s perceived barriers. This was verified...... barriers, there were both inter- and intra-gender differences in the children´s perceptions of these barriers. Weather was a barrier for all children, apart from the most active boys. Conflicts were perceived as a barrier particularly for those boys who played ballgames. Girls said they would like to have...

  6. Physical Activity and Telomere Biology: Exploring the Link with Aging-Related Disease Prevention

    OpenAIRE

    Andrew T. Ludlow; Stephen M. Roth

    2011-01-01

    Physical activity is associated with reduced risk of several age-related diseases as well as with increased longevity in both rodents and humans. Though these associations are well established, evidence of the molecular and cellular factors associated with reduced disease risk and increased longevity resulting from physical activity is sparse. A long-standing hypothesis of aging is the telomere hypothesis: as a cell divides, telomeres shorten resulting eventually in replicative senescence and...

  7. A Vision for the Exploration of Mars: Robotic Precursors Followed by Humans to Mars Orbit in 2033

    Science.gov (United States)

    Sellers, Piers J.; Garvin, James B.; Kinney, Anne L.; Amato, Michael J.; White, Nicholas E.

    2012-01-01

    The reformulation of the Mars program gives NASA a rare opportunity to deliver a credible vision in which humans, robots, and advancements in information technology combine to open the deep space frontier to Mars. There is a broad challenge in the reformulation of the Mars exploration program that truly sets the stage for: 'a strategic collaboration between the Science Mission Directorate (SMD), the Human Exploration and Operations Mission Directorate (HEOMD) and the Office of the Chief Technologist, for the next several decades of exploring Mars'.Any strategy that links all three challenge areas listed into a true long term strategic program necessitates discussion. NASA's SMD and HEOMD should accept the President's challenge and vision by developing an integrated program that will enable a human expedition to Mars orbit in 2033 with the goal of returning samples suitable for addressing the question of whether life exists or ever existed on Mars

  8. Motives and activities for continuing professional development: An exploration of their relationships by integrating literature and interview data.

    Science.gov (United States)

    Pool, Inge A; Poell, Rob F; Berings, Marjolein G M C; Ten Cate, Olle

    2016-03-01

    To effectively enhance professional development, it is important to understand the motivational factors behind nurses' engagement in particular types of learning activities. Nurses have various motives for professional development and utilise different learning activities. Not much is known about how these relate. The aim of this study was to explore the relationship between nurses' motives and activities for continuing professional development, by examining in which types of learning activities nurses engage, with which motives, and whether certain motives are associated with certain learning activities. A qualitative study using semi-structured interviews. Twenty-one nurses in academic and general Dutch hospitals participated. Interview data on nurses' learning biographies were analysed using a literature-based framework on motives and learning activities for continuing professional development. As recent classifications of nurses' motives for professional development were absent, the literature was reviewed for motives, using three databases. The interview transcripts were analysed for motives, learning activities and their relationships. Nine motives and four categories of learning activities for continuing professional development were delineated. Increasing competence was the primary motive that stimulated nurses to engage in self-directed learning during work, and in formal learning activities. To comply with requirements, they engaged in mandatory courses. To deepen knowledge, they registered for conferences. To develop their careers, they enrolled in postgraduate education. Five other motives were not mentioned as frequently. Specific motives were found to be related to engagement in particular learning activities. Nurses could use these findings to increase their awareness of why and how they develop professionally, and managers and human resource development professionals could develop approaches that would better suit nurses' needs. Copyright © 2016

  9. Action Search: Learning to Search for Human Activities in Untrimmed Videos

    KAUST Repository

    Alwassel, Humam

    2017-06-13

    Traditional approaches for action detection use trimmed data to learn sophisticated action detector models. Although these methods have achieved great success at detecting human actions, we argue that huge information is discarded when ignoring the process, through which this trimmed data is obtained. In this paper, we propose Action Search, a novel approach that mimics the way people annotate activities in video sequences. Using a Recurrent Neural Network, Action Search can efficiently explore a video and determine the time boundaries during which an action occurs. Experiments on the THUMOS14 dataset reveal that our model is not only able to explore the video efficiently but also accurately find human activities, outperforming state-of-the-art methods.

  10. Cooperation and dialogical modeling for designing a safe Human space exploration mission to Mars

    Science.gov (United States)

    Grès, Stéphane; Tognini, Michel; Le Cardinal, Gilles; Zalila, Zyed; Gueydan, Guillaume

    2014-11-01

    This paper proposes an approach for a complex and innovative project requiring international contributions from different communities of knowledge and expertise. Designing a safe and reliable architecture for a manned mission to Mars or the Asteroids necessitates strong cooperation during the early stages of design to prevent and reduce risks for the astronauts at each step of the mission. The stake during design is to deal with the contradictions, antagonisms and paradoxes of the involved partners for the definition and modeling of a shared project of reference. As we see in our research which analyses the cognitive and social aspects of technological risks in major accidents, in such a project, the complexity of the global organization (during design and use) and the integration of a wide and varie d range of sciences and innovative technologies is likely to increase systemic risks as follows: human and cultural mistakes, potential defaults, failures and accidents. We identify as the main danger antiquated centralized models of organization and the operational limits of interdisciplinarity in the sciences. Beyond this, we can see that we need to take carefully into account human cooperation and the quality of relations between heterogeneous partners. Designing an open, self-learning and reliable exploration system able to self-adapt in dangerous and unforeseen situations implies a collective networked intelligence led by a safe process that organizes interaction between the actors and the aims of the project. Our work, supported by the CNES (French Space Agency), proposes an innovative approach to the coordination of a complex project.

  11. Instrumental Neutron Activation Analysis for Human Hair

    International Nuclear Information System (INIS)

    Ratanatongchai, W.; Dharmvanij, W; Chongkum, S.

    1998-01-01

    Hair samples from students aged between 7 to 22 years old were analysed by neutron activation analysis at nuclear research reactor TRR-1.M1. From qualitative analysis of short-lived isotopes, A1, V, Ca, I, Cl, Mn, and Na were found. The quantity of those elements can be classified into three groups. The first group is A1, Ca, Na and Cl with variance less than 10%. The second group is V and I with variance between 10% to 50% and the third group, Mn, two samples have concentration about 12 times higher than the others

  12. Natural radiation exposure modified by human activities

    International Nuclear Information System (INIS)

    Fujimoto, Kenzo

    1995-01-01

    We are now living in the radiation environment modified by our technology. It is usually called 'Technologically Enhanced Natural Radiation' and have been discussed in the UNSCEAR Reports as an important source of exposure. The terrestrial radionuclide concentrations as well as the intensity of cosmic rays are considered to have been constant after our ancestors came down from trees and started walking on their two feet. However, we have been changing our environment to be more comfortable for our life and consequently ambient radiation levels are nomore what used to be. In this paper exposures due to natural radiation modified by our following activities are discussed: housing, balneology, cave excursion, mountain climbing, skiing, swimming, smoking and usage of mineral water, well water, coal, natural gas, phosphate rocks and minerals. In the ICRP Publication No. 39, it is clearly mentioned that even natural radiation should be controlled as far as it is controllable. We have to pay more attention to our activities not to enhance the exposure due to unnecessary, avoidable radiation. (author)

  13. Quantifying the impact of human activity on temperatures in Germany

    Science.gov (United States)

    Benz, Susanne A.; Bayer, Peter; Blum, Philipp

    2017-04-01

    Human activity directly influences ambient air, surface and groundwater temperatures. Alterations of surface cover and land use influence the ambient thermal regime causing spatial temperature anomalies, most commonly heat islands. These local temperature anomalies are primarily described within the bounds of large and densely populated urban settlements, where they form so-called urban heat islands (UHI). This study explores the anthropogenic impact not only for selected cities, but for the thermal regime on a countrywide scale, by analyzing mean annual temperature datasets in Germany in three different compartments: measured surface air temperature (SAT), measured groundwater temperature (GWT), and satellite-derived land surface temperature (LST). As a universal parameter to quantify anthropogenic heat anomalies, the anthropogenic heat intensity (AHI) is introduced. It is closely related to the urban heat island intensity, but determined for each pixel (for satellite-derived LST) or measurement point (for SAT and GWT) of a large, even global, dataset individually, regardless of land use and location. Hence, it provides the unique opportunity to a) compare the anthropogenic impact on temperatures in air, surface and subsurface, b) to find main instances of anthropogenic temperature anomalies within the study area, in this case Germany, and c) to study the impact of smaller settlements or industrial sites on temperatures. For all three analyzed temperature datasets, anthropogenic heat intensity grows with increasing nighttime lights and declines with increasing vegetation, whereas population density has only minor effects. While surface anthropogenic heat intensity cannot be linked to specific land cover types in the studied resolution (1 km × 1 km) and classification system, both air and groundwater show increased heat intensities for artificial surfaces. Overall, groundwater temperature appears most vulnerable to human activity; unlike land surface temperature

  14. Exploring nutritional status, physical activity and body mass index of Pakistani teens

    OpenAIRE

    Kiran Khan; Nazia Jameel; Rehana Khalil; Saadia Gul

    2016-01-01

    Background: Obesity is becoming an increasingly prevalent problem in Pakistan, as it has in other developing countries. Childhood obesity poses high cost to the well-being and negatively affects children's health, causes chronic disease as children grow older. The aim of this study was to explore nutritional status, physical activity and body mass index (BMI) of school and college going students of mid and late adolescence age (14 to 19 years) studying in multi-ethnic city of Karachi, Pakista...

  15. Exploring the Use of Activity Patterns for Smart Monitoring of Nuclear Facilities

    Energy Technology Data Exchange (ETDEWEB)

    Miller, Karen Ann [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-07-10

    The world is at an inflection point where our ability to collect data now far outpaces our ability to make use of it. LANL has a number of efforts to help us pull more meaningful insights out of our data and target resources to where they will be most impactful. We are exploring an approach to recognizing activity patterns across disparate data streams for a more holistic view of nuclear facility monitoring.

  16. Exploring space-time structure of human mobility in urban space

    Science.gov (United States)

    Sun, J. B.; Yuan, J.; Wang, Y.; Si, H. B.; Shan, X. M.

    2011-03-01

    Understanding of human mobility in urban space benefits the planning and provision of municipal facilities and services. Due to the high penetration of cell phones, mobile cellular networks provide information for urban dynamics with a large spatial extent and continuous temporal coverage in comparison with traditional approaches. The original data investigated in this paper were collected by cellular networks in a southern city of China, recording the population distribution by dividing the city into thousands of pixels. The space-time structure of urban dynamics is explored by applying Principal Component Analysis (PCA) to the original data, from temporal and spatial perspectives between which there is a dual relation. Based on the results of the analysis, we have discovered four underlying rules of urban dynamics: low intrinsic dimensionality, three categories of common patterns, dominance of periodic trends, and temporal stability. It implies that the space-time structure can be captured well by remarkably few temporal or spatial predictable periodic patterns, and the structure unearthed by PCA evolves stably over time. All these features play a critical role in the applications of forecasting and anomaly detection.

  17. Exploring the martian moons a human mission to Deimos and Phobos

    CERN Document Server

    von Ehrenfried, Manfred “Dutch”

    2017-01-01

    This book explores the once popular idea of 'Flexible Path' in terms of Mars, a strategy that would focus on a manned orbital mission to Mars's moons rather than the more risky, expensive and time-consuming trip to land humans on the Martian surface. While currently still not the most popular idea, this mission would take advantage of the operational, scientific and engineering lessons to be learned from going to Mars's moons first. Unlike a trip to the planet's surface, an orbital mission avoids the dangers of the deep gravity well of Mars and a very long stay on the surface. This is analogous to Apollo 8 and 10, which preceded the landing on the Moon of Apollo 11. Furthermore, a Mars orbital mission could be achieved at least five years, possibly 10 before a landing mission. Nor would an orbital mission require all of the extra vehicles, equipment and supplies needed for a landing and a stay on the planet for over a year. The cost difference between the two types of missions is in the order of tens of billi...

  18. 'Becoming human again': Exploring connections between nature and recovery from stress and post-traumatic distress.

    Science.gov (United States)

    Westlund, Stephanie

    2015-01-01

    Many military veterans are seeking ways beyond conventional treatments to manage their stress injuries. An increasing number is turning to nature, including hiking and fishing, farming and gardening, and building relationships with dogs or horses. Many continue to benefit from medication and therapy, but find that nature provides an additional measure of support, relief and healing in their lives. This paper examines reciprocal interactions between humans and nature during post-conflict recovery, with a focus on the experiences of four North American veterans who regard their personal recovery from stressful and traumatic military experiences as intimately tied to their nature experiences. Experience-centered narrative inquiry often sheds light on details and experiences concealed or overlooked by other research paradigms. In-depth interviews about post-military experiences with recovery were conducted with four veterans who suffer from stress and/or post-traumatic distress; these experiences are further illuminated by supporting interviews, and theories and praxis in ecopsychology, cognitive science, neuroscience, biophilia, and ecological intelligence. Through exploring themes of sensory experience, safety, sense of purpose, and renewed relationships, this research gives space to former soldiers' stories of experience and to their individual realizations that their embodied interconnections with nature provide alternative experiences to their military training and combat exposure. The veterans' experiences with nature and recovery are pointing towards an avenue of recovery that is little acknowledged in the mainstream literature and praxis, but deserving of attention.

  19. Human Research Program (HRP) Exploration Medical Capability (ExMC) Standing Review Panel (SRP)

    Science.gov (United States)

    Cintron, Nitza; Dutson, Eric; Friedl, Karl; Hyman, William; Jemison, Mae; Klonoff, David

    2009-01-01

    The SRP believes strongly that regularly performed in-flight crew assessments are needed in order to identify a change in health status before a medical condition becomes clinically apparent. It is this early recognition in change that constitutes the foundation of the "occupational health model" expounded in the HRP Requirements Document as a key component of the HRP risk mitigation strategy that will enable its objective of "prevention and mitigation of human health and performance risks". A regular crew status examination of physiological and clinical performance is needed. This can be accomplished through instrumented monitoring of routine embedded tasks. The SRP recommends addition of a new gap to address this action under Category 3.0 Mitigate the Risk. This new gap is closely associated with Task 4.19 which addresses the lack of adequate biomedical monitoring capabilities for performing periodic clinical status evaluations and contingency medical monitoring. A corollary to these gaps is the critical emphasis on preventive medicine, not only during pre- and post-flight phases of a mission as is the current practice, but continued into the in-flight phases of exploration class missions.

  20. Exploring continuous and integrated strategies for the up- and downstream processing of human mesenchymal stem cells.

    Science.gov (United States)

    Cunha, Bárbara; Aguiar, Tiago; Silva, Marta M; Silva, Ricardo J S; Sousa, Marcos F Q; Pineda, Earl; Peixoto, Cristina; Carrondo, Manuel J T; Serra, Margarida; Alves, Paula M

    2015-11-10

    The integration of up- and downstream unit operations can result in the elimination of hold steps, thus decreasing the footprint, and ultimately can create robust closed system operations. This type of design is desirable for the bioprocess of human mesenchymal stem cells (hMSC), where high numbers of pure cells, at low volumes, need to be delivered for therapy applications. This study reports a proof of concept of the integration of a continuous perfusion culture in bioreactors with a tangential flow filtration (TFF) system for the concentration and washing of hMSC. Moreover, we have also explored a continuous alternative for concentrating hMSC. Results show that expanding cells in a continuous perfusion operation mode provided a higher expansion ratio, and led to a shift in cells' metabolism. TFF operated either in continuous or discontinuous allowed to concentrate cells, with high cell recovery (>80%) and viability (>95%); furthermore, continuous TFF permitted to operate longer with higher cell concentrations. Continuous diafiltration led to higher protein clearance (98%) with lower cell death, when comparing to discontinuous diafiltration. Overall, an integrated process allowed for a shorter process time, recovering 70% of viable hMSC (>95%), with no changes in terms of morphology, immunophenotype, proliferation capacity and multipotent differentiation potential. Copyright © 2015 Elsevier B.V. All rights reserved.

  1. Towards human exploration of space: The THESEUS review series on nutrition and metabolism research priorities.

    Science.gov (United States)

    Bergouignan, Audrey; Stein, T Peter; Habold, Caroline; Coxam, Veronique; O' Gorman, Donal; Blanc, Stéphane

    2016-01-01

    Nutrition has multiple roles during space flight from providing sufficient nutrients to meet the metabolic needs of the body and to maintain good health, to the beneficial psychosocial aspects related to the meals. Nutrition is central to the functioning of the body; poor nutrition compromises all the physiological systems. Nutrition is therefore likely to have a key role in counteracting the negative effects of space flight (e.g., radiation, immune deficits, oxidative stress, and bone and muscle loss). As missions increase in duration, any dietary/nutritional deficiencies will become progressively more detrimental. Moreover, it has been recognized that the human diet contains, in addition to essential macronutrients, a complex array of naturally occurring bioactive micronutrients that may confer significant long-term health benefits. It is therefore critical that astronauts be adequately nourished during missions. Problems of nutritional origin are often treatable by simply providing the appropriate nutrients and adequate recommendations. This review highlights six key issues that have been identified as space research priorities in nutrition field: in-flight energy balance; altered feeding behavior; development of metabolic stress; micronutrient deficiency; alteration of gut microflora; and altered fluid and electrolytes balance. For each of these topics, relevance for space exploration, knowledge gaps and proposed investigations are described. Finally, the nutritional questions related to bioastronautics research are very relevant to multiple ground-based-related health issues. The potential spin-offs are both interesting scientifically and potentially of great clinical importance.

  2. VESsel GENeration Analysis (VESGEN): Innovative Vascular Mappings for Astronaut Exploration Health Risks and Human Terrestrial Medicine

    Science.gov (United States)

    Parsons-Wingerter, Patricia; Kao, David; Valizadegan, Hamed; Martin, Rodney; Murray, Matthew C.; Ramesh, Sneha; Sekaran, Srinivaas

    2017-01-01

    Currently, astronauts face significant health risks in future long-duration exploration missions such as colonizing the Moon and traveling to Mars. Numerous risks include greatly increased radiation exposures beyond the low earth orbit (LEO) of the ISS, and visual and ocular impairments in response to microgravity environments. The cardiovascular system is a key mediator in human physiological responses to radiation and microgravity. Moreover, blood vessels are necessarily involved in the progression and treatment of vascular-dependent terrestrial diseases such as cancer, coronary vessel disease, wound-healing, reproductive disorders, and diabetes. NASA developed an innovative, globally requested beta-level software, VESsel GENeration Analysis (VESGEN) to map and quantify vascular remodeling for application to astronaut and terrestrial health challenges. VESGEN mappings of branching vascular trees and networks are based on a weighted multi-parametric analysis derived from vascular physiological branching rules. Complex vascular branching patterns are determined by biological signaling mechanisms together with the fluid mechanics of multi-phase laminar blood flow.

  3. Antivirulence activity of the human gut metabolome.

    Science.gov (United States)

    Antunes, L Caetano M; McDonald, Julie A K; Schroeter, Kathleen; Carlucci, Christian; Ferreira, Rosana B R; Wang, Melody; Yurist-Doutsch, Sophie; Hira, Gill; Jacobson, Kevan; Davies, Julian; Allen-Vercoe, Emma; Finlay, B Brett

    2014-07-29

    The mammalian gut contains a complex assembly of commensal microbes termed microbiota. Although much has been learned about the role of these microbes in health, the mechanisms underlying these functions are ill defined. We have recently shown that the mammalian gut contains thousands of small molecules, most of which are currently unidentified. Therefore, we hypothesized that these molecules function as chemical cues used by hosts and microbes during their interactions in health and disease. Thus, a search was initiated to identify molecules produced by the microbiota that are sensed by pathogens. We found that a secreted molecule produced by clostridia acts as a strong repressor of Salmonella virulence, obliterating expression of the Salmonella pathogenicity island 1 as well as host cell invasion. It has been known for decades that the microbiota protects its hosts from invading pathogens, and these data suggest that chemical sensing may be involved in this phenomenon. Further investigations should reveal the exact biological role of this molecule as well as its therapeutic potential. Importance: Microbes can communicate through the production and sensing of small molecules. Within the complex ecosystem formed by commensal microbes living in and on the human body, it is likely that these molecular messages are used extensively during the interactions between different microbial species as well as with host cells. Deciphering such a molecular dialect will be fundamental to our understanding of host-microbe interactions in health and disease and may prove useful for the design of new therapeutic strategies that target these mechanisms of communication. Copyright © 2014 Antunes et al.

  4. Human Activity and Pollution in Antarctica

    Science.gov (United States)

    Graf, H.-F.; Shirsat, S. V.; Podzun, R.

    2009-04-01

    A regional climate chemistry model is used to determine the level of pollution of the Antarctic continent due to anthropogenic and natural emission of sulphur species. Based on an emission inventory for the year 2004/2005 including emissions from energy use and ground traffic at and between Antarctic research stations, flight activity, tourist and scientific ship operations, and emissions from the Mt. Erebus volcano, atmospheric concentration and deposition rates of sulphur species and black carbon were simulated at 0.5 degree resolution for the whole Antarctic continent. The biggest anthropogenic source of pollution is ship operations. These concentrate near the Antarctic Peninsula and close to the big scientific stations at Queen Maud Land and in the Ross sea area. The prevailing winds guarantee that most of the anthropogenic emissions from sources near the coast will be blown to lower latitudes and do not affect the continent. While atmospheric concentrations over vast areas remain extremely low, in some places locally concentrations and deposition rates are reached that may be detectable by in-situ measurements and give rise to concern. Especially at the Peninsula atmospheric concentrations and surface deposition of sulphur and soot are dominated by ship emissions. The largest part of shipping activity in this region is from tourist ships, a strongly increasing business. The by far biggest source of sulphur species in Antarctica is the Mt. Erebus volcano. It is also the only source that remains equally strong in polar winter. However, due to its high altitude and the long life time of SO2, especially in winter resulting in long range transport and dilution, Erebus emissions contribute relatively little to deposition of sulphur in the most anthropogenic polluted areas while they dominate the sulphur deposition in central Antarctica.

  5. Exploring the activity profile of health care assistants and nurses in home nursing.

    Science.gov (United States)

    De Vliegher, Kristel; Aertgeerts, Bert; Declercq, Anja; Moons, Philip

    2015-12-01

    Are home nurses (also known as community nurses) ready for their changing role in primary care? A quantitative study was performed in home nursing in Flanders, Belgium, to explore the activity profile of home nurses and health care assistants, using the 24-hour recall instrument for home nursing. Seven dates were determined, covering each day of the week and the weekend, on which data collection would take place. All the home nurses and health care assistants from the participating organisations across Flanders were invited to participate in the study. All data were measured at nominal level. A total of 2478 home nurses and 277 health care assistants registered 336 128 (47 977 patients) and 36 905 (4558 patients) activities, respectively. Home nurses and health care assistants mainly perform 'self-care facilitation' activities in combination with 'psychosocial care' activities. Health care assistants also support home nurses in the 'selfcare facilitation' of patients who do not have a specific nursing indication.

  6. A functional MRI Exploration of Hamstring Activation During the Supine Bridge Exercise.

    Science.gov (United States)

    Bourne, Matthew; Williams, Morgan; Pizzari, Tania; Shield, Anthony

    2018-02-01

    The single leg supine bridge (SLB) is a commonly employed strengthening exercise and is used as a clinical test for hamstring function in sports, however, little is known about the patterns of muscle activation in this task. To explore these activation patterns, nine healthy, recreationally active males underwent functional magnetic resonance imaging (fMRI) of their thighs at rest and immediately after 5 sets of 10 repetitions of the SLB exercise. Exercise-induced increases in the transverse (T2) relaxation time of the biceps femoris long and short heads, semitendinosus and semimembranosus, were determined via signal intensity changes in pre- and post-exercise images and used as an index of muscle activation. The Bonferroni adjusted alpha was set at phamstring injury prevention and rehabilitation programs. © Georg Thieme Verlag KG Stuttgart · New York.

  7. A personal history of the human exploration initiative with commentary on the pivotal role for life support research

    Science.gov (United States)

    Mendell, Wendell

    1990-01-01

    The author relates the history of the human exploration initiative from a personal perspective from the 1961 J. F. Kennedy initiative to land a man on the moon up to 1986 when a memo was circulated from NASA Headquarters to its employees which stated as a major goal the expansion of the human presence beyond Earth into the solar system. The pivotal role of life support research is woven into this personalized history.

  8. Anti-complement activities of human breast-milk.

    Science.gov (United States)

    Ogundele, M O

    1999-08-01

    It has long been observed that the human milk possesses significant anti-inflammatory properties, while simultaneously protecting the infant against many intestinal and respiratory pathogens. There is, however, a paucity of information on the degree and extent of this anti-inflammatory activity. In the present study, the inhibitory effects of different fractions of human milk on serum complement activity were analysed. Colostrum and milk samples from healthy voluntary lactating donors at different postpartum ages were obtained and pooled normal human serum was used as source of complement in a modified CH50 assay. Inherent complement activity in human milk was also investigated by measuring the deposition of an activated C3 fragment on a serum-sensitive bacteria, and by haemolytic assays. Most whole- and defatted-milk samples consistently showed a dose-dependent inhibition of the serum complement activity. This inhibition was greater in mature milk compared to transitional milk samples. It was enhanced by inactivation of milk complement, and diminished by centrifugation of milk samples, which partly removed fat and larger protein components including casein micelles. Inherent complement activity in human milk was also demonstrated by haemolysis of sensitised sheep erythrocytes and deposition of C3 fragments on solid-phase bacteria. These activities were highest in the colostrum and gradually decreased as lactation proceeded. Several natural components abundant in the fluid phase of the human breast-milk have been shown to be inhibitors of complement activation in vitro. Their physiological significance probably reside in their ability to prevent inflammatory-induced tissue damage of the delicate immature gastrointestinal tract of the new-born as well as the mammary gland itself, which may arise from ongoing complement activation.

  9. Antiproliferative activity of recombinant human interferon-λ2 ...

    African Journals Online (AJOL)

    Antiproliferative activity of recombinant human interferon-λ2 expressed in stably ... The representing 26 kDa protein band of IFN-λ2 was detected by SDS-PAGE and ... The antiproliferative activity of hIFN-λ2 was determined by MTT assay.

  10. A Hierarchical Representation for Human Activity Recognition with Noisy Labels

    NARCIS (Netherlands)

    Hu, N.; Englebienne, G.; Lou, Z.; Kröse, B.

    2015-01-01

    Human activity recognition is an essential task for robots to effectively and efficiently interact with the end users. Many machine learning approaches for activity recognition systems have been proposed recently. Most of these methods are built upon a strong assumption that the labels in the

  11. Human activity understanding for robot-assisted living

    NARCIS (Netherlands)

    Hu, N.

    2016-01-01

    This thesis investigated the problem of understanding human activities, at different levels of granularity and taking into account both the variability in activities and annotator disagreement. To be able to capture the large variations within each of the action classes, we propose a model that uses

  12. Regulation of calcium homeostasis in activated human neutrophils ...

    African Journals Online (AJOL)

    Objectives. The objectives of the current study were to: (i) present an integrated model for the restoration of calcium homeostasis in activated human neutrophils based on current knowledge and recent research; and (ii) identify potential targets for the modulation of calcium fluxes in activated neutrophils based on this model ...

  13. The Musician as (In)Active Athlete?: Exploring the Association Between Physical Activity and Musculoskeletal Complaints in Music Students.

    Science.gov (United States)

    Baadjou, Vera A E; Verbunt, Jeanine A M C F; van Eijsden-Besseling, Marjon D F; Huysmans, Stephanie M D; Smeets, Rob J E M

    2015-12-01

    Musicians are often compared to athletes because of the physical exertion required to play music. The aim of this study was to explore the physical activity level of music students and to study its relationship with musculoskeletal complaints. A second goal was to assess associations between physical activity and pain, quality of life, and disability. This cross-sectional study among third- and fourth-year music students used an electronic survey including measures for physical activity (SQUASH-Short Questionnaire to Assess Health-enhancing physical activity), musculoskeletal complaints (DMQ-Dutch Musculoskeletal Questionnaire), disability (DASH-Disability Arm, Shoulder, Hand questionnaire) and quality of life (Short Form-12). Students were classified as compliers or non-compliers with moderate- and vigorous-intensity physical activity recommendations. Statistical analysis was done using (non)parametric tests (t-test, Pearson chi-square test, Mann-Whitney U-test) and correlational testing. Participants were 132 students, 63.6% female, with a median age of 23 yrs (range 21.3-25.0). 67% reported musculoskeletal complaints in the past 7 days. Their median physical activity level was 6,390 MET-min/wk, and 62% and 10% of the students accomplished recommendations for moderate-intensity and vigorous-intensity physical activity levels, respectively. No significant differences were found in prevalence of musculoskeletal complaints between students who met moderate- or vigorous-intensity physical activity recommendations and students who did not. Physical activity level was not associated with musculoskeletal complaints (r=0.12, p=0.26). Higher pain intensity was associated with a lower quality of life (r=-0.53 pMusic students are mainly involved in light- to moderate-intensity physical activities and rarely in vigorous-intensity activities. No correlation was found between physical activity level in the past months and musculoskeletal complaints in music students.

  14. Application of the Human Activity Assistive Technology model for occupational therapy research.

    Science.gov (United States)

    Giesbrecht, Ed

    2013-08-01

    Theoretical models provide a framework for describing practice and integrating evidence into systematic research. There are few models that relate specifically to the provision of assistive technology in occupational therapy practice. The Human Activity Assistive Technology model is an enduring example that has continued to develop by integrating a social model of disability, concepts from occupational therapy theory and principles of assistive technology adoption and abandonment. This study first describes the core concepts of the Human Activity Assistive Technology model and reviews its development over three successive published versions. A review of the research literature reflects application of the model to clinical practice, study design, outcome measure selection and interpretation of results, particularly among occupational therapists. An evaluative framework is used to critique the adequacy of the Human Activity Assistive Technology model for practice and research, exploring attributes of clarity, simplicity, generality, accessibility and importance. Finally, recommendations are proposed for continued development of the model and research applications. Most of the existing research literature employs the Human Activity Assistive Technology model for background and study design; there is emerging evidence to support the core concepts as predictive factors. Although the concepts are generally simple, clear and applicable to occupational therapy practice and research, evolving terminology and outcomes become more complex with the conflation of integrated theories. The development of the Human Activity Assistive Technology model offers enhanced access and application for occupational therapists, but poses challenges to clarity among concepts. Suggestions are made for further development and applications of the model. © 2013 Occupational Therapy Australia.

  15. Fire, Climate, and Human Activity: A Combustive Combination

    Science.gov (United States)

    Kehrwald, N. M.; Battistel, D.; Argiriadis, E.; Barbante, C.; Barber, L. B.; Fortner, S. K.; Jasmann, J.; Kirchgeorg, T.; Zennaro, P.

    2017-12-01

    Ice and lake core records demonstrate that fires caused by human activity can dominate regional biomass burning records in the Common Era. These major increases in fires are often associated with extensive land use change such as an expansion in agriculture. Regions with few humans, relatively stable human populations and/or unvarying land use often have fire histories that are dominated by climate parameters such as temperature and precipitation. Here, we examine biomass burning recorded in ice cores from northern Greenland (NEEM, (77°27'N; 51°3.6'W), Alaska (Juneau Icefield, 58° 35' N; 134° 29'W) and East Antarctica (EPICA DOME C; 75°06'S; 123°21'E), along with New Zealand lake cores to investigate interactions between climate, fire and human activity. Biomarkers such as levoglucosan, and its isomers mannosan and galactosan, can only be produced by cellulose combustion and therefore are specific indicators of past fire activity archived in ice and lake cores. These fire histories add another factor to climate proxies from the same core, and provide a comparison to regional fire syntheses from charcoal records and climate models. For example, fire data from the JSBACH-Spitfire model for the past 2000 years demonstrates that a climate-only scenario would not increase biomass burning in high northern latitudes for the past 2000 years, while NEEM ice core and regional pollen records demonstrate both increased fire activity and land use change that may be ascribed to human activity. Additional biomarkers such as fecal sterols in lake sediments can determine when people were in an area, and can help establish if an increased human presence in an area corresponds with intensified fire activity. This combination of specific biomarkers, other proxy data, and model output can help determine the relative impact of humans versus climate factors on regional fire activity.

  16. Phenol-Explorer 2.0: a major update of the Phenol-Explorer database integrating data on polyphenol metabolism and pharmacokinetics in humans and experimental animals

    Science.gov (United States)

    Rothwell, Joseph A.; Urpi-Sarda, Mireia; Boto-Ordoñez, Maria; Knox, Craig; Llorach, Rafael; Eisner, Roman; Cruz, Joseph; Neveu, Vanessa; Wishart, David; Manach, Claudine; Andres-Lacueva, Cristina; Scalbert, Augustin

    2012-01-01

    Phenol-Explorer, launched in 2009, is the only comprehensive web-based database on the content in foods of polyphenols, a major class of food bioactives that receive considerable attention due to their role in the prevention of diseases. Polyphenols are rarely absorbed and excreted in their ingested forms, but extensively metabolized in the body, and until now, no database has allowed the recall of identities and concentrations of polyphenol metabolites in biofluids after the consumption of polyphenol-rich sources. Knowledge of these metabolites is essential in the planning of experiments whose aim is to elucidate the effects of polyphenols on health. Release 2.0 is the first major update of the database, allowing the rapid retrieval of data on the biotransformations and pharmacokinetics of dietary polyphenols. Data on 375 polyphenol metabolites identified in urine and plasma were collected from 236 peer-reviewed publications on polyphenol metabolism in humans and experimental animals and added to the database by means of an extended relational design. Pharmacokinetic parameters have been collected and can be retrieved in both tabular and graphical form. The web interface has been enhanced and now allows the filtering of information according to various criteria. Phenol-Explorer 2.0, which will be periodically updated, should prove to be an even more useful and capable resource for polyphenol scientists because bioactivities and health effects of polyphenols are dependent on the nature and concentrations of metabolites reaching the target tissues. The Phenol-Explorer database is publicly available and can be found online at http://www.phenol-explorer.eu. Database URL: http://www.phenol-explorer.eu PMID:22879444

  17. Exploring factors associated with sexual activity in community-dwelling older adults.

    Science.gov (United States)

    Killinger, Kim A; Boura, Judith A; Diokno, Ananias C

    2014-01-01

    Sexuality is an important, yet often overlooked, aspect of successful aging. The current article explores potential relationships between sexual activity in older adults and marital status, health, mobility, urinary incontinence, and caffeine and alcohol use, as well as sexual desire and erectile function in women and men, respectively. A survey was mailed to community-dwelling older adults 60 and older. Of 242 respondents (79% ages 60 to 74, 53% male), 159 (65.7%) were sexually active. A higher proportion of sexually active adults were married (p = 0.0005), had better health (p = 0.0003), and drank alcohol (p = 0.007). A lower proportion of sexually active adults had urinary incontinence (p = 0.006). Similar proportions of men and women were sexually active (62.8% and 68.2%, respectively; p = 0.38). Sexually active women had better sexual desire scores (p Sexually active men had better mobility (p = 0.012) and erectile function (p sexually active men had incontinence (p sexual health in older adults. Copyright 2014, SLACK Incorporated.

  18. Physical Activity: Exploring Views of Older Russian-Speaking Slavic Immigrants

    Directory of Open Access Journals (Sweden)

    Janet Purath

    2011-01-01

    Full Text Available Many of the 1.3 million Russian-speaking immigrants in the US have chronic conditions such as cardiovascular disease, diabetes, obesity, and depression. They engage in physical activity less often than other groups, and little is known about their views of physical activity. This qualitative study explored physical activity attitudes, beliefs, motivators, and barriers among older Russian-speaking immigrants. In four focus group interviews, 23 participants discussed physical activity. “Movement is life” was a theme throughout all interviews. Walking was the most frequently mentioned activity. Increased energy and decreased pain were described as health benefits. Motivators for physical activity were maintaining function, improved health, and the support of God and family. Barriers included poor health and environmental safety concerns. Participants suggested community walking groups and church-supported programs as useful methods to promote physical activity. Future research includes developing culturally appropriate interventions that utilize physical activity to prevent and manage chronic illness with ethnic minority older adults.

  19. Activation of peroxisome proliferator-activated receptor-α enhances fatty acid oxidation in human adipocytes

    International Nuclear Information System (INIS)

    Lee, Joo-Young; Hashizaki, Hikari; Goto, Tsuyoshi; Sakamoto, Tomoya; Takahashi, Nobuyuki; Kawada, Teruo

    2011-01-01

    Highlights: → PPARα activation increased mRNA expression levels of adipocyte differentiation marker genes and GPDH activity in human adipocytes. → PPARα activation also increased insulin-dependent glucose uptake in human adipocytes. → PPARα activation did not affect lipid accumulation in human adipocytes. → PPARα activation increased fatty acid oxidation through induction of fatty acid oxidation-related genes in human adipocytes. -- Abstract: Peroxisome proliferator-activated receptor-α (PPARα) is a key regulator for maintaining whole-body energy balance. However, the physiological functions of PPARα in adipocytes have been unclarified. We examined the functions of PPARα using human multipotent adipose tissue-derived stem cells as a human adipocyte model. Activation of PPARα by GW7647, a potent PPARα agonist, increased the mRNA expression levels of adipocyte differentiation marker genes such as PPARγ, adipocyte-specific fatty acid-binding protein, and lipoprotein lipase and increased both GPDH activity and insulin-dependent glucose uptake level. The findings indicate that PPARα activation stimulates adipocyte differentiation. However, lipid accumulation was not changed, which is usually observed when PPARγ is activated. On the other hand, PPARα activation by GW7647 treatment induced the mRNA expression of fatty acid oxidation-related genes such as CPT-1B and AOX in a PPARα-dependent manner. Moreover, PPARα activation increased the production of CO 2 and acid soluble metabolites, which are products of fatty acid oxidation, and increased oxygen consumption rate in human adipocytes. The data indicate that activation of PPARα stimulates both adipocyte differentiation and fatty acid oxidation in human adipocytes, suggesting that PPARα agonists could improve insulin resistance without lipid accumulation in adipocytes. The expected effects of PPARα activation are very valuable for managing diabetic conditions accompanied by obesity, because

  20. A qualitative study exploring women’s beliefs about physical activity after stillbirth

    Science.gov (United States)

    2014-01-01

    Background Research provides strong evidence for improvements in depressive symptoms as a result of physical activity participation in many populations including pregnant and post-partum women. Little is known about how women who have experienced stillbirth (defined as fetal death at 20 or more weeks of gestation) feel about physical activity or use physical activity following this experience. The purpose of this study was to qualitatively explore women’s beliefs about physical activity following a stillbirth. Methods This was an exploratory qualitative research study. Participants were English-speaking women between the ages of 19 and 44 years who experienced a stillbirth in the past year from their recruitment date. Interviews were conducted over the phone or in-person based on participants’ preferences and location of residence and approximately 30–45 minutes in length. Results Twenty-four women participated in the study (M age = 33 ± 3.68 years; M time since stillbirth = 6.33 ± 3.06 months). Women’s beliefs about physical activity after stillbirth were coded into the following major themes: barriers to physical activity (emotional symptoms and lack of motivation, tired, lack of time, guilt, letting go of a pregnant body, and seeing other babies), benefits to physical activity (feeling better emotionally/mentally, helping women to cope or be therapeutic), importance of physical activity (working through grief, time for self), motivators for physical activity (body shape/weight, health, more children, be a role model, already an exerciser). Health care providers and their role in physical activity participation was also a major theme. Conclusions This is the first study to qualitatively explore beliefs about physical activity in women after a stillbirth. Women who have experienced stillbirth have unique beliefs about physical activity related to their experience with stillbirth. Findings from this study may help to improve the health

  1. A qualitative study exploring women's beliefs about physical activity after stillbirth.

    Science.gov (United States)

    Huberty, Jennifer L; Coleman, Jason; Rolfsmeyer, Katherine; Wu, Serena

    2014-01-17

    Research provides strong evidence for improvements in depressive symptoms as a result of physical activity participation in many populations including pregnant and post-partum women. Little is known about how women who have experienced stillbirth (defined as fetal death at 20 or more weeks of gestation) feel about physical activity or use physical activity following this experience. The purpose of this study was to qualitatively explore women's beliefs about physical activity following a stillbirth. This was an exploratory qualitative research study. Participants were English-speaking women between the ages of 19 and 44 years who experienced a stillbirth in the past year from their recruitment date. Interviews were conducted over the phone or in-person based on participants' preferences and location of residence and approximately 30-45 minutes in length. Twenty-four women participated in the study (M age = 33 ± 3.68 years; M time since stillbirth = 6.33 ± 3.06 months). Women's beliefs about physical activity after stillbirth were coded into the following major themes: barriers to physical activity (emotional symptoms and lack of motivation, tired, lack of time, guilt, letting go of a pregnant body, and seeing other babies), benefits to physical activity (feeling better emotionally/mentally, helping women to cope or be therapeutic), importance of physical activity (working through grief, time for self), motivators for physical activity (body shape/weight, health, more children, be a role model, already an exerciser). Health care providers and their role in physical activity participation was also a major theme. This is the first study to qualitatively explore beliefs about physical activity in women after a stillbirth. Women who have experienced stillbirth have unique beliefs about physical activity related to their experience with stillbirth. Findings from this study may help to improve the health and quality of life for women who have experienced stillbirth by

  2. The Challenges of Integrating NASA's Human, Budget, and Data Capital within the Constellation Program's Exploration Launch Projects Office

    Science.gov (United States)

    Kidd, Luanne; Morris, Kenneth B.; Self, Timothy A.

    2007-01-01

    The U.S. Vision for Space Exploration directs NASA to retire the Space Shuttle in 2010 and replace it with safe, reliable, and cost-effective space transportation systems for crew and cargo travel to the Moon, Mars, and beyond. Such emerging space transportation initiatives face massive organizational challenges, including building and nurturing an experienced, dedicated team with the right skills for the required tasks; allocating and tracking the fiscal capital invested in achieving technical progress against an integrated master schedule; and turning generated data into useful knowledge that equips the team to design and develop superior products for customers and stakeholders. It has been more than 30 years since the Space Shuttle was designed; therefore, the current aerospace workforce has limited experience with developing new designs for human-rated spaceflight hardware. To accomplish these activities, NASA is using a wide range of state-of-the-art information technology tools that connect its diverse, decentralized teams and provide timely, accurate information for decision makers. In addition, business professionals are assisting technical managers with planning, tracking, and forecasting resource use against an integrated master schedule that horizontally and vertically interlinks hardware elements and milestone events. Furthermore, NASA is employing a wide variety of strategies to ensure that it has the motivated and qualified staff it needs for the tasks ahead. This paper discusses how NASA's Exploration Launch Projects Office, which is responsible for delivering these new launch vehicles, integrates its resources to create an engineering business environment that promotes mission success, which is defined by replacing the Space Shuttle by 2014 and returning to the Moon by 2020.

  3. Exploring the effects of telehealth on medical human resources supply: a qualitative case study in remote regions

    Directory of Open Access Journals (Sweden)

    Duplantie Julie

    2007-01-01

    Full Text Available Abstract Background The availability of medical human resource supply is a growing concern for rural and remote communities in many countries. In the last decade, various telehealth experiences in Canada have highlighted the potential impact of this technology on professional practice. The purpose of this study was to explore physicians' and managers' perceptions regarding the potential of telehealth to support recruitment and retention of physicians in remote and rural regions. Methods A case study in Eastern Quebec was performed to explore this complex phenomenon. The analytical framework was based on two literature reviews and a Delphi study. Data were collected from semi-structured interviews with 41 physicians and 22 managers. Transcripts were produced and interview content was coded independently by two judges and validated by an expert panel. Results Interviews have highlighted the potential impact of telehealth on several factors influencing the recruitment and retention of physicians in rural and remote regions. The potential effects of telehealth on physicians' choice of practice location could be seen at the professional, organizational, educational and individual levels. For instance, telehealth could improve work satisfaction by allowing a regional on-call duty system and a better follow-up of patients. However, there are also certain limits related to telehealth, such as the fear that it would eventually replace all continuing medical education activities and onsite specialists in remoteregions. Conclusion Telehealth is likely to have an impact on several factors related to medical workforce supply in remote and rural regions. However, the expected benefits will materialize if and only if this technology is properly integrated into organizations as a support to professional practice.

  4. Exploring resting-state EEG brain oscillatory activity in relation to cognitive functioning in multiple sclerosis.

    Science.gov (United States)

    Keune, Philipp M; Hansen, Sascha; Weber, Emily; Zapf, Franziska; Habich, Juliane; Muenssinger, Jana; Wolf, Sebastian; Schönenberg, Michael; Oschmann, Patrick

    2017-09-01

    Neurophysiologic monitoring parameters related to cognition in Multiple Sclerosis (MS) are sparse. Previous work reported an association between magnetoencephalographic (MEG) alpha-1 activity and information processing speed. While this remains to be replicated by more available electroencephalographic (EEG) methods, also other established EEG markers, e.g. the slow-wave/fast-wave ratio (theta/beta ratio), remain to be explored in this context. Performance on standard tests addressing information processing speed and attention (Symbol-Digit Modalities Test, SDMT; Test of Attention Performance, TAP) was examined in relation to resting-state EEG alpha-1 and alpha-2 activity and the theta/beta ratio in 25MS patients. Increased global alpha-1 and alpha-2 activity and an increased frontal theta/beta ratio (pronounced slow-wave relative to fast-wave activity) were associated with lower SDMT processing speed. In an exploratory analysis, clinically impaired attention was associated with a significantly increased frontal theta/beta ratio whereas alpha power did not show sensitivity to clinical impairment. EEG global alpha power and the frontal theta/beta ratio were both associated with attention. The theta/beta ratio involved potential clinical sensitivity. Resting-state EEG recordings can be obtained during the routine clinical process. The examined resting-state measures may represent feasible monitoring parameters in MS. This notion should be explored in future intervention studies. Copyright © 2017 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.

  5. Exploring Connections Between Earth Science and Biology - Interdisciplinary Science Activities for Schools

    Science.gov (United States)

    Vd Flier-Keller, E.; Carolsfeld, C.; Bullard, T.

    2009-05-01

    To increase teaching of Earth science in schools, and to reflect the interdisciplinary nature and interrelatedness of science disciplines in today's world, we are exploring opportunities for linking Earth science and Biology through engaging and innovative hands-on science activities for the classroom. Through the NSERC-funded Pacific CRYSTAL project based at the University of Victoria, scientists, science educators, and teachers at all levels in the school system are collaborating to research ways of enriching the preparation of students in math and science, and improving the quality of science education from Kindergarten to Grade 12. Our primary foci are building authentic, engaging science experiences for students, and fostering teacher leadership through teacher professional development and training. Interdisciplinary science activities represent an important way of making student science experiences real, engaging and relevant, and provide opportunities to highlight Earth science related topics within other disciplines, and to expand the Earth science taught in schools. The Earth science and Biology interdisciplinary project builds on results and experiences of existing Earth science education activities, and the Seaquaria project. We are developing curriculum-linked activities and resource materials, and hosting teacher workshops, around two initial areas; soils, and marine life and the fossil record. An example activity for the latter is the hands-on examination of organisms occupying the nearshore marine environment using a saltwater aquarium and touch tank or beach fieldtrip, and relating this to a suite of marine fossils to facilitate student thinking about representation of life in the fossil record e.g. which life forms are typically preserved, and how are they preserved? Literacy activities such as fossil obituaries encourage exploration of paleoenvironments and life habits of fossil organisms. Activities and resources are being tested with teachers

  6. Human Activity Recognition from Body Sensor Data using Deep Learning.

    Science.gov (United States)

    Hassan, Mohammad Mehedi; Huda, Shamsul; Uddin, Md Zia; Almogren, Ahmad; Alrubaian, Majed

    2018-04-16

    In recent years, human activity recognition from body sensor data or wearable sensor data has become a considerable research attention from academia and health industry. This research can be useful for various e-health applications such as monitoring elderly and physical impaired people at Smart home to improve their rehabilitation processes. However, it is not easy to accurately and automatically recognize physical human activity through wearable sensors due to the complexity and variety of body activities. In this paper, we address the human activity recognition problem as a classification problem using wearable body sensor data. In particular, we propose to utilize a Deep Belief Network (DBN) model for successful human activity recognition. First, we extract the important initial features from the raw body sensor data. Then, a kernel principal component analysis (KPCA) and linear discriminant analysis (LDA) are performed to further process the features and make them more robust to be useful for fast activity recognition. Finally, the DBN is trained by these features. Various experiments were performed on a real-world wearable sensor dataset to verify the effectiveness of the deep learning algorithm. The results show that the proposed DBN outperformed other algorithms and achieves satisfactory activity recognition performance.

  7. Venus Mobile Explorer with RPS for Active Cooling: A Feasibility Study

    Science.gov (United States)

    Leifer, Stephanie D.; Green, Jacklyn R.; Balint, Tibor S.; Manvi, Ram

    2009-01-01

    We present our findings from a study to evaluate the feasibility of a radioisotope power system (RPS) combined with active cooling to enable a long-duration Venus surface mission. On-board power with active cooling technology featured prominently in both the National Research Council's Decadal Survey and in the 2006 NASA Solar System Exploration Roadmap as mission-enabling for the exploration of Venus. Power and cooling system options were reviewed and the most promising concepts modeled to develop an assessment tool for Venus mission planners considering a variety of future potential missions to Venus, including a Venus Mobile Explorer (either a balloon or rover concept), a long-lived Venus static lander, or a Venus Geophysical Network. The concepts modeled were based on the integration of General Purpose Heat Source (GPHS) modules with different types of Stirling cycle heat engines for power and cooling. Unlike prior investigations which reported on single point design concepts, this assessment tool allows the user to generate either a point design or parametric curves of approximate power and cooling system mass, power level, and number of GPHS modules needed for a "black box" payload housed in a spherical pressure vessel.

  8. Exploring Value Orientations toward the Human-Nature Relationship: A Comparison of Urban Youth in Minnesota, USA and Guangdong, China

    Science.gov (United States)

    Li, Jie; Ernst, Julie

    2015-01-01

    Research exploring urban youths' value orientations toward the human-nature relationship was conducted with 59 students from a school in Minneapolis, Minnesota (USA) and 51 students from a school in Guangzhou, Guangdong (China). Quantitative findings suggest that the majority of participants in both groups shared a similar value orientation,…

  9. Exploring the smallest active fragment of HsQSOX1b and finding a highly efficient oxidative engine.

    Directory of Open Access Journals (Sweden)

    Wenyun Zheng

    Full Text Available Human quiescin-sulfhydryl oxidase 1 isoform b (HsQSOX1b is a highly efficient, multiple-domain enzyme that directly inserts disulfide bonds into client protein. However, previous studies have focused mainly on the catalytic activity of the whole protein rather than its domain structure. In this research, we dissected the structure and function of HsQSOX1b and explored its mechanism as a highly efficient sulfhydryl oxidase by analyzing the truncated variants. The results showed that the first HsQSOX1b thioredoxin domain was essential for thiol oxidase activity. The smallest active fragment (SAQ was identified to consist of a helix-rich region (HRR and an essential for respiration and viability/augmenter of liver regeneration (ERV/ALR domain, which remained highly active to oxidize an artificial non-thiol substrate but not small molecular and protein thiols. Our study clearly demonstrated that SAQ is a highly efficient oxidative engine, which shows high efficiency in the de novo disulfide formation and oxygen reduction and that this more efficient oxidative engine is necessary for the highly efficient catalysis of QSOXs compared to Erv1 and Erv2. This study will help address the roles of different HsQSOX1b domains in de novo disulfide formation and encourage the engineering of more efficient QSOX variants for the in vitro folding of disulfide-containing proteins.

  10. Conformal Ablative Thermal Protection System for Planetary and Human Exploration Missions

    Science.gov (United States)

    Beck, R.; Arnold, J.; Gasch, M.; Stackpole, M.; Wercinski, R.; Venkatapathy, E.; Fan, W.; Thornton, J; Szalai, C.

    2012-01-01

    The Office of Chief Technologist (OCT), NASA has identified the need for research and technology development in part from NASAs Strategic Goal 3.3 of the NASA Strategic Plan to develop and demonstrate the critical technologies that will make NASAs exploration, science, and discovery missions more affordable and more capable. Furthermore, the Game Changing Development Program (GCDP) is a primary avenue to achieve the Agencys 2011 strategic goal to Create the innovative new space technologies for our exploration, science, and economic future. In addition, recently released NASA Space Technology Roadmaps and Priorities, by the National Research Council (NRC) of the National Academy of Sciences stresses the need for NASA to invest in the very near term in specific EDL technologies. The report points out the following challenges (Page 2-38 of the pre-publication copy released on February 1, 2012): Mass to Surface: Develop the ability to deliver more payload to the destination. NASA's future missions will require ever-greater mass delivery capability in order to place scientifically significant instrument packages on distant bodies of interest, to facilitate sample returns from bodies of interest, and to enable human exploration of planets such as Mars. As the maximum mass that can be delivered to an entry interface is fixed for a given launch system and trajectory design, the mass delivered to the surface will require reductions in spacecraft structural mass more efficient, lighter thermal protection systems more efficient lighter propulsion systems and lighter, more efficient deceleration systems. Surface Access: Increase the ability to land at a variety of planetary locales and at a variety of times. Access to specific sites can be achieved via landing at a specific location(s) or transit from a single designated landing location, but it is currently infeasible to transit long distances and through extremely rugged terrain, requiring landing close to the site of

  11. Exploring the Human Plasma Proteome for Humoral Mediators of Remote Ischemic Preconditioning - A Word of Caution

    Science.gov (United States)

    Helgeland, Erik; Breivik, Lars Ertesvåg; Vaudel, Marc; Svendsen, Øyvind Sverre; Garberg, Hilde; Nordrehaug, Jan Erik; Berven, Frode Steingrimsen; Jonassen, Anne Kristine

    2014-01-01

    Despite major advances in early revascularization techniques, cardiovascular diseases are still the leading cause of death worldwide, and myocardial infarctions contribute heavily to this. Over the past decades, it has become apparent that reperfusion of blood to a previously ischemic area of the heart causes damage in and of itself, and that this ischemia reperfusion induced injury can be reduced by up to 50% by mechanical manipulation of the blood flow to the heart. The recent discovery of remote ischemic preconditioning (RIPC) provides a non-invasive approach of inducing this cardioprotection at a distance. Finding its endogenous mediators and their operative mode is an important step toward increasing the ischemic tolerance. The release of humoral factor(s) upon RIPC was recently demonstrated and several candidate proteins were published as possible mediators of the cardioprotection. Before clinical applicability, these potential biomarkers and their efficiency must be validated, a task made challenging by the large heterogeneity in reported data and results. Here, in an attempt to reproduce and provide more experimental data on these mediators, we conducted an unbiased in-depth analysis of the human plasma proteome before and after RIPC. From the 68 protein markers reported in the literature, only 28 could be mapped to manually reviewed (Swiss-Prot) protein sequences. 23 of them were monitored in our untargeted experiment. However, their significant regulation could not be reproducibly estimated. In fact, among the 394 plasma proteins we accurately quantified, no significant regulation could be confidently and reproducibly assessed. This indicates that it is difficult to both monitor and reproduce published data from experiments exploring for RIPC induced plasma proteomic regulations, and suggests that further work should be directed towards small humoral factors. To simplify this task, we made our proteomic dataset available via ProteomeXchange, where

  12. An exploration of diffusion tensor eigenvector variability within human calf muscles.

    Science.gov (United States)

    Rockel, Conrad; Noseworthy, Michael D

    2016-01-01

    To explore the effect of diffusion tensor imaging (DTI) acquisition parameters on principal and minor eigenvector stability within human lower leg skeletal muscles. Lower leg muscles were evaluated in seven healthy subjects at 3T using an 8-channel transmit/receive coil. Diffusion-encoding was performed with nine signal averages (NSA) using 6, 15, and 25 directions (NDD). Individual DTI volumes were combined into aggregate volumes of 3, 2, and 1 NSA according to number of directions. Tensor eigenvalues (λ1 , λ2 , λ3 ), eigenvectors (ε1 , ε2 , ε3 ), and DTI metrics (fractional anisotropy [FA] and mean diffusivity [MD]) were calculated for each combination of NSA and NDD. Spatial maps of signal-to-noise ratio (SNR), λ3 :λ2 ratio, and zenith angle were also calculated for region of interest (ROI) analysis of vector orientation consistency. ε1 variability was only moderately related to ε2 variability (r = 0.4045). Variation of ε1 was affected by NDD, not NSA (P < 0.0002), while variation of ε2 was affected by NSA, not NDD (P < 0.0003). In terms of tensor shape, vector variability was weakly related to FA (ε1 :r = -0.1854, ε2 : ns), but had a stronger relation to the λ3 :λ2 ratio (ε1 :r = -0.5221, ε2 :r = -0.1771). Vector variability was also weakly related to SNR (ε1 :r = -0.2873, ε2 :r = -0.3483). Zenith angle was found to be strongly associated with variability of ε1 (r = 0.8048) but only weakly with that of ε2 (r = 0.2135). The second eigenvector (ε2 ) displayed higher directional variability relative to ε1 , and was only marginally affected by experimental conditions that impacted ε1 variability. © 2015 Wiley Periodicals, Inc.

  13. Innovative Application of Mechanical Activation for Rare Earth Elements Recovering: Process Optimization and Mechanism Exploration

    Science.gov (United States)

    Tan, Quanyin; Deng, Chao; Li, Jinhui

    2016-01-01

    With the rapidly expanding use of fluorescent lamps (FLs) and increasing interest in conservation and sustainable utilization of critical metals such as rare earth elements (REEs), the recovering of REEs from phosphors in waste FLs is becoming a critical environmental and economic issue. To effectively recycle REEs with metallurgical methods, mechanical activation by ball milling was introduced to pretreat the waste phosphors. This current study put the emphasis on the mechanical activation and leaching processes for REEs, and explored the feasibility of the method from both theoretical and practical standpoints. Results showed physicochemical changes of structural destruction and particle size reduction after mechanical activation, leading to the easy dissolution of REEs in the activated samples. Under optimal conditions, dissolution yields of 89.4%, 93.1% and 94.6% for Tb, Eu and Y, respectively, were achieved from activated waste phosphors using hydrochloric acid as the dissolution agent. The shrinking core model proved to be the most applicable for the leaching procedure, with an apparent activation energy of 10.96 ± 2.79 kJ/mol. This novel process indicates that mechanical activation is an efficient method for recovering REEs from waste phosphors, and it has promising potential for REE recovery with low cost and high efficiency.

  14. Visual image reconstruction from human brain activity: A modular decoding approach

    International Nuclear Information System (INIS)

    Miyawaki, Yoichi; Uchida, Hajime; Yamashita, Okito; Sato, Masa-aki; Kamitani, Yukiyasu; Morito, Yusuke; Tanabe, Hiroki C; Sadato, Norihiro

    2009-01-01

    Brain activity represents our perceptual experience. But the potential for reading out perceptual contents from human brain activity has not been fully explored. In this study, we demonstrate constraint-free reconstruction of visual images perceived by a subject, from the brain activity pattern. We reconstructed visual images by combining local image bases with multiple scales, whose contrasts were independently decoded from fMRI activity by automatically selecting relevant voxels and exploiting their correlated patterns. Binary-contrast, 10 x 10-patch images (2 100 possible states), were accurately reconstructed without any image prior by measuring brain activity only for several hundred random images. The results suggest that our approach provides an effective means to read out complex perceptual states from brain activity while discovering information representation in multi-voxel patterns.

  15. Environmental impact monitoring of U exploration activity in river water at Kalan Area West Kalimantan 2008

    International Nuclear Information System (INIS)

    AS Soediro; A Dedi; A Djuhara; T Wismawati; A Nugroho; S Widarti

    2010-01-01

    U exploration at Kalan (Eko Remaja, Lemajung, Semut) will produce the environment impact of flora, fauna and society. The objective monitoring is to detect and measure the environmental change quality component caused by U exploration activity in river water at Kalan area. The monitoring were done by analyze river water sample were taken at the same place previously year. Analysis river water sample such as Ca, Mg, Fe, Ni, Zn, radioactivity U at Eko Remaja, Lemajung, Semut have shown nearly equal to the result of previous years and still below the limited value. Water quality Kalan (that scale 4.9 for Eko Remaja, Lemajung and 4.8 for Semut, it means, that's safe for environment. (author)

  16. Advances in Distributed Operations and Mission Activity Planning for Mars Surface Exploration

    Science.gov (United States)

    Fox, Jason M.; Norris, Jeffrey S.; Powell, Mark W.; Rabe, Kenneth J.; Shams, Khawaja

    2006-01-01

    A centralized mission activity planning system for any long-term mission, such as the Mars Exploration Rover Mission (MER), is completely infeasible due to budget and geographic constraints. A distributed operations system is key to addressing these constraints; therefore, future system and software engineers must focus on the problem of how to provide a secure, reliable, and distributed mission activity planning system. We will explain how Maestro, the next generation mission activity planning system, with its heavy emphasis on portability and distributed operations has been able to meet these design challenges. MER has been an excellent proving ground for Maestro's new approach to distributed operations. The backend that has been developed for Maestro could benefit many future missions by reducing the cost of centralized operations system architecture.

  17. Social Robotic Experience and Media Communication Practices: An Exploration on the Emotional and Ritualized Human-technology-relations

    Directory of Open Access Journals (Sweden)

    Christine Linke

    2013-01-01

    Full Text Available This article approaches the subject of social robots by focusing on the emotional relations people establish with media and information and communication technology (ICTs in their everyday life. It examines human-technology-relation from a social studies point of view, seeking to raise questions that enable us to make a connection between the research on human relationships and the topic of human-technology relation, especially human-humanoid-relation. In order to explore the human-technology-relations, theoretical ideas of a mediatization of communication and of a ritual interaction order are applied. Ritual theory is particularly used to enable a focus on emotion as a significant dimension in analyzing social technologies. This explorative article refers to empirical findings regarding media communication practices in close relationships. It argues that following the developed approach regarding mediatized and ritualized relational practices, useful insights for a conceptualization of the human-social robot relation can be achieved. The article concludes with remarks regarding the challenge of an empirical approach to human-social robot-relations.

  18. The current uranium exploration activities of the Power Reactor and Nuclear Fuel Development Corporation (PNC), Japan

    International Nuclear Information System (INIS)

    Miyada, H.

    2001-01-01

    As of November 1996, Japan's total installed commercial nuclear power generation capacity was 42 GW(e), accounting for 34% of total electric energy generation. By 2010, Japan intends to have an installed electricity generation capacity of 70.5 GW(e). This will increase the country's demand for nat Ural uranium from 7,700 t U in 1994 (13% of the world consumption) to 13,800 t U in 2010 (17%-19% of the world projected consumption). However, Japan's known uranium resources at Ningyo-Toge and Tono deposits, are estimated at roughly only 6,600 t U. The Long-term Programme for Research, Development and Utilization of Nuclear Energy (adopted in 1994) calls for diversification through long-term purchasing contracts, independent exploration and involvement in mining vent Ures, with the objective of ensuring independence and stability in Japan's development and utilization of nuclear energy. The Power Reactor and Nuclear Fuel Development Corporation (PNC) has been commissioned to carry out the task of independent exploration. PNC is carrying out exploration projects in Canada, Australia, USA and China targeting unconformity related type deposits with an eye to privatizing them. Currently about 40,000 t U of uranium resources are held by PNC. PNC has been carrying out the following related activities: (1) Reference surveys on uranium resources to delineate the promising areas; (2) Development of uranium exploration technology; (3) Information surveys on the nuclear industries to project long-term supply and demand; (4) International Cooperation programme on uranium exploration with Asian countries. (author)

  19. A Multiscale Survival Process for Modeling Human Activity Patterns.

    Science.gov (United States)

    Zhang, Tianyang; Cui, Peng; Song, Chaoming; Zhu, Wenwu; Yang, Shiqiang

    2016-01-01

    Human activity plays a central role in understanding large-scale social dynamics. It is well documented that individual activity pattern follows bursty dynamics characterized by heavy-tailed interevent time distributions. Here we study a large-scale online chatting dataset consisting of 5,549,570 users, finding that individual activity pattern varies with timescales whereas existing models only approximate empirical observations within a limited timescale. We propose a novel approach that models the intensity rate of an individual triggering an activity. We demonstrate that the model precisely captures corresponding human dynamics across multiple timescales over five orders of magnitudes. Our model also allows extracting the population heterogeneity of activity patterns, characterized by a set of individual-specific ingredients. Integrating our approach with social interactions leads to a wide range of implications.

  20. Modeling and Visualization of Human Activities for Multicamera Networks

    Directory of Open Access Journals (Sweden)

    Aswin C. Sankaranarayanan

    2009-01-01

    Full Text Available Multicamera networks are becoming complex involving larger sensing areas in order to capture activities and behavior that evolve over long spatial and temporal windows. This necessitates novel methods to process the information sensed by the network and visualize it for an end user. In this paper, we describe a system for modeling and on-demand visualization of activities of groups of humans. Using the prior knowledge of the 3D structure of the scene as well as camera calibration, the system localizes humans as they navigate the scene. Activities of interest are detected by matching models of these activities learnt a priori against the multiview observations. The trajectories and the activity index for each individual summarize the dynamic content of the scene. These are used to render the scene with virtual 3D human models that mimic the observed activities of real humans. In particular, the rendering framework is designed to handle large displays with a cluster of GPUs as well as reduce the cognitive dissonance by rendering realistic weather effects and illumination. We envision use of this system for immersive visualization as well as summarization of videos that capture group behavior.

  1. Detection of cardiac activity changes from human speech

    Science.gov (United States)

    Tovarek, Jaromir; Partila, Pavol; Voznak, Miroslav; Mikulec, Martin; Mehic, Miralem

    2015-05-01

    Impact of changes in blood pressure and pulse from human speech is disclosed in this article. The symptoms of increased physical activity are pulse, systolic and diastolic pressure. There are many methods of measuring and indicating these parameters. The measurements must be carried out using devices which are not used in everyday life. In most cases, the measurement of blood pressure and pulse following health problems or other adverse feelings. Nowadays, research teams are trying to design and implement modern methods in ordinary human activities. The main objective of the proposal is to reduce the delay between detecting the adverse pressure and to the mentioned warning signs and feelings. Common and frequent activity of man is speaking, while it is known that the function of the vocal tract can be affected by the change in heart activity. Therefore, it can be a useful parameter for detecting physiological changes. A method for detecting human physiological changes by speech processing and artificial neural network classification is described in this article. The pulse and blood pressure changes was induced by physical exercises in this experiment. The set of measured subjects was formed by ten healthy volunteers of both sexes. None of the subjects was a professional athlete. The process of the experiment was divided into phases before, during and after physical training. Pulse, systolic, diastolic pressure was measured and voice activity was recorded after each of them. The results of this experiment describe a method for detecting increased cardiac activity from human speech using artificial neural network.

  2. 3D Data Acquisition Platform for Human Activity Understanding

    Science.gov (United States)

    2016-03-02

    SECURITY CLASSIFICATION OF: In this project, we incorporated motion capture devices, 3D vision sensors, and EMG sensors to cross validate...multimodality data acquisition, and address fundamental research problems of representation and invariant description of 3D data, human motion modeling and...applications of human activity analysis, and computational optimization of large-scale 3D data. The support for the acquisition of such research

  3. Mapping Cumulative Impacts of Human Activities on Marine Ecosystems

    OpenAIRE

    , Seaplan

    2018-01-01

    Given the diversity of human uses and natural resources that converge in coastal waters, the potential independent and cumulative impacts of those uses on marine ecosystems are important to consider during ocean planning. This study was designed to support the development and implementation of the 2009 Massachusetts Ocean Management Plan. Its goal was to estimate and visualize the cumulative impacts of human activities on coastal and marine ecosystems in the state and federal waters off of Ma...

  4. Coaching the exploration and exploitation in active learning for interactive video retrieval.

    Science.gov (United States)

    Wei, Xiao-Yong; Yang, Zhen-Qun

    2013-03-01

    Conventional active learning approaches for interactive video/image retrieval usually assume the query distribution is unknown, as it is difficult to estimate with only a limited number of labeled instances available. Thus, it is easy to put the system in a dilemma whether to explore the feature space in uncertain areas for a better understanding of the query distribution or to harvest in certain areas for more relevant instances. In this paper, we propose a novel approach called coached active learning that makes the query distribution predictable through training and, therefore, avoids the risk of searching on a completely unknown space. The estimated distribution, which provides a more global view of the feature space, can be used to schedule not only the timing but also the step sizes of the exploration and the exploitation in a principled way. The results of the experiments on a large-scale data set from TRECVID 2005-2009 validate the efficiency and effectiveness of our approach, which demonstrates an encouraging performance when facing domain-shift, outperforms eight conventional active learning methods, and shows superiority to six state-of-the-art interactive video retrieval systems.

  5. Differentially activated macrophages orchestrate myogenic precursor cell fate during human skeletal muscle regeneration

    DEFF Research Database (Denmark)

    Saclier, Marielle; Yacoub-Youssef, Houda; Mackey, Abigail

    2013-01-01

    , we explored both in vitro and in vivo, in human, the interactions of differentially activated MPs with myogenic precursor cells (MPCs) during adult myogenesis and skeletal muscle regeneration. We showed in vitro that through the differential secretion of cytokines and growth factors, proinflammatory...... anti-inflammatory markers. These data demonstrate for the first time in human that MPs sequentially orchestrate adult myogenesis during regeneration of damaged skeletal muscle. These results support the emerging concept that inflammation, through MP activation, controls stem cell fate and coordinates......Macrophages (MPs) exert either beneficial or deleterious effects on tissue repair, depending on their activation/polarization state. They are crucial for adult skeletal muscle repair, notably by acting on myogenic precursor cells. However, these interactions have not been fully characterized. Here...

  6. Exploring integral controllers in actively-lubricated tilting-pad journal bearings

    DEFF Research Database (Denmark)

    Salazar, Jorge Andrés González; Santos, Ilmar

    2015-01-01

    investigation of integral controllers for feedback-controlled lubrication with the aim of: a) presetting the static journal center and consequently exploring the changes of bearing dynamic properties; b) obtaining an integral controller capable of re-positioning the static journal eccentricity for matching......Active tilting-pad journal bearings with radial oil injection combine good stability properties of conventional tilting-pad journal bearings with the capability of improving their dynamic properties even more by control techniques. The main contribution of this work is the experimental...

  7. Impact of the human activities on the climate

    International Nuclear Information System (INIS)

    Deque, M.

    2007-01-01

    In the framework of the A2 scenario of the GIEC, the possible impacts on the french climate, of the human activities are examined. It seems that the human activities imposed and will be able to impose a faster change of the climate than the natural changes. For the hundred coming years the main characteristics could be: an increase of the temperature, an increase of the rains in winter and a decrease in summer, a decrease of the water in soils expected in freezing areas and an increase of the drought periods. (A.L.B.)

  8. Chloride transport in human fibroblasts is activated by hypotonic shock

    Energy Technology Data Exchange (ETDEWEB)

    Rugolo, M.; Mastocola, T.; Flamigni, A.; Lenaz, G. (Universita' di Bologna (Italy))

    1989-05-15

    Incubation of human skin fibroblasts in hypotonic media induced the activation of {sup 36}Cl- efflux which was roughly proportional to the decrease in the osmolality of the media. The efflux of {sup 36}Cl- was insensitive to DIDS plus furosemide and inhibited by addition of a Cl- channel blocker such as 5-nitro-2-(3-phenyl propylamino) benzoic acid (NPPB). We propose that a conductive pathway for Cl- transport, almost silent in isotonic conditions, is activated by exposing human fibroblasts to hypotonic shock, this conclusion being supported by evidence that also {sup 36}Cl- influx was enhanced by hypotonic medium.

  9. Human Reliability Assessment and Human Performance Evaluation: Research and Analysis Activities at the U.S. NRC

    International Nuclear Information System (INIS)

    Ramey-Smith, A.M.

    1998-01-01

    The author indicates the themes of the six programs identified by the US NRC mission on human performance and human reliability activities. They aim at developing the technical basis to support human performance, at developing and updating a model of human performance and human reliability, at fostering national and international dialogue and cooperation efforts on human performance evaluation, at conducting operating events analysis and database development, and at providing support to human performance and human reliability inspection

  10. Young (gold deposits and active geothermal systems of the Great Basin: Enigmas, questions, and exploration potential

    Science.gov (United States)

    Coolbaugh, Mark F.; Vikre, Peter G.; Faulds, James E.

    2011-01-01

    remobilized from older gold mineralization? Current research is investigating these and other questions to improve our genetic understanding of these young gold systems, which in turn can lead to improved exploration targeting. The recent rapid growth in resources for both young gold deposits and geothermal systems underscores their underdeveloped exploration potential. Even though many young gold deposits exhibit relatively shallow hot-springs-style mineralization, their young age may preclude exposure by erosion. Uplift along active normal faults has exposed some deposits (e.g., Florida Canyon, Dixie Comstock, Wind Mountain), but in other areas, such as the Walker Lane, where strike-slip faulting is prevalent, the opportunities for exposure can be limited. Many active geothermal systems are also concealed below the surface in that hot springs or steam vents may be absent above areas of thermal groundwater.With sources of energy to support mine production becoming more problematic, the potential advantages of simultaneously exploring for young gold deposits and spatially associated geothermal systems are becoming more apparent. Exploration methods recently proven effective in geothermal exploration that can be adapted to gold exploration include temperature surveys, hyperspectral remote sensing, geophysical surveys, water analyses, and detailed mapping of geothermal-related features and related fault systems.

  11. Exploring the use of thermal infrared imaging in human stress research.

    Directory of Open Access Journals (Sweden)

    Veronika Engert

    Full Text Available High resolution thermal infrared imaging is a pioneering method giving indices of sympathetic activity via the contact-free recording of facial tissues (thermal imprints. Compared to established stress markers, the great advantage of this method is its non-invasiveness. The goal of our study was to pilot the use of thermal infrared imaging in the classical setting of human stress research. Thermal imprints were compared to established stress markers (heart rate, heart rate variability, finger temperature, alpha-amylase and cortisol in 15 participants undergoing anticipation, stress and recovery phases of two laboratory stress tests, the Cold Pressor Test and the Trier Social Stress Test. The majority of the thermal imprints proved to be change-sensitive in both tests. While correlations between the thermal imprints and established stress markers were mostly non-significant, the thermal imprints (but not the established stress makers did correlate with stress-induced mood changes. Multivariate pattern analysis revealed that in contrast to the established stress markers the thermal imprints could not disambiguate anticipation, stress and recovery phases of both tests. Overall, these results suggest that thermal infrared imaging is a valuable method for the estimation of sympathetic activity in the stress laboratory setting. The use of this non-invasive method may be particularly beneficial for covert recordings, in the study of special populations showing difficulties in complying with the standard instruments of data collection and in the domain of psychophysiological covariance research. Meanwhile, the established stress markers seem to be superior when it comes to the characterization of complex physiological states during the different phases of the stress cycle.

  12. Magnetogastrographic detection of gastric electrical response activity in humans

    International Nuclear Information System (INIS)

    Irimia, Andrei; Richards, William O; Bradshaw, L Alan

    2006-01-01

    The detection and characterization of gastric electrical activity has important clinical applications, including the early diagnosis of gastric diseases in humans. In mammals, this phenomenon has two important features: an electrical control activity (ECA) that manifests itself as an electric slow wave (with a frequency of 3 cycles per minute in humans) and an electrical response activity (ERA) that is characterized by spiking potentials during the plateau phase of the ECA. Whereas the ECA has been recorded in humans both invasively and non-invasively (magnetogastrography-MGG), the ERA has never been detected non-invasively in humans before. In this paper, we report on our progress towards the non-invasive detection of ERA from the human stomach using a procedure that involves the application of principal component analysis to MGG recordings, which were acquired in our case from ten normal human patients using a Superconducting QUantum Interference Device (SQUID) magnetometer. Both pre- and post-prandial recordings were acquired for each patient and 20 min of recordings (10 min of pre-prandial and 10 min of post-prandial data) were analysed for each patient. The mean percentage of ECA slow waves that were found to exhibit spikes of suspected ERA origin was 41% and 61% for pre- and post-prandial recordings, respectively, implying a 47% ERA increase post-prandially (P < 0.0001 at a 95% confidence level). The detection of ERA in humans is highly encouraging and points to the possible use of non-invasive ERA recordings as a valuable tool for the study of human gastric disorders

  13. From outer space to Earth-The social significance of isolated and confined environment research in human space exploration

    Science.gov (United States)

    Tachibana, Koji; Tachibana, Shoichi; Inoue, Natsuhiko

    2017-11-01

    Human space exploration requires massive budgets every fiscal year. Especially under severe financial constraint conditions, governments are forced to justify to society why spending so much tax revenue for human space exploration is worth the cost. The value of human space exploration might be estimated in many ways, but its social significance and cost-effectiveness are two key ways to gauge that worth. Since these measures should be applied country by country because sociopolitical conditions differ in each country and must be taken into consideration, the study on the social significance of human space exploration must take the coloration of a case-study. This paper, focusing on the case of Japan with surveying Japanese literary and national documents as well as taking its sociopolitical conditions into account, examines the social significance of human space exploration. First, we give an overview of the circumstances surrounding Japan's human space exploration program. Derived from the statements of such relevant parties as scholars, journalists, policy makers, and astronauts, this overview indicates that the main concerns about human space exploration in Japan are its social significance and cost-effectiveness (Section 1). Next, an overview of behavioral science-an essential field for human space exploration (referred to in this paper as space behavioral science) that provides support for astronauts-is presented from the perspective of stress research in isolated and confined environments (Section 2). We then give two examples of where such knowledge from space behavioral science research has been applied to terrestrial isolated and confined environments. One is JAXA's support in 2009 for people who were vulnerable to infection by a new strain of flu and accordingly placed in an isolated and confined facility under the Infectious Disease Law and the Quarantine Law. The other is NASA's support in 2010 for Chilean mine workers who were trapped 700 m

  14. Applications of Intelligent Tutoring Systems to Human-Robotic Exploration of Mars

    Science.gov (United States)

    Clancey, William J.

    2004-01-01

    Space missions with small crews extending over several years with time-delay preventing normal conversations with people on earth will raise many challenges for training. Of special interest are possible three-year missions to Mars, requiring refresher instruction and learning new skills based on unexpected problems with machines and environmental conditions. For example, the crew will be required to monitor and repair more complex life support systems for air and water recycling than we even know how to build today. Highly educated astronauts, often with several doctorate degrees, require a very different mode of interaction than we have developed for school children or even typical college students. Explanation methods may need to differ-using analogies and techniques from different domains-depending on whether the astronaut is an astrophysicist, a pilot, or a geologist.Virtual reality (e.g., for Hubble repair missions) and "integrated" simulations (involving role-playing and emphasizing failure scenarios) are the most common advanced forms of instruction used in space flight today. The emphasis is on collaborative, embodied interaction with the same workstations and tools used in practice (e.g., a cockpit simulator). Otherwise, computerized instructional technology used by NASA is not model-based or tutorial in nature. This discussion will review some of the key instructional methods used at NASA over the past two decades and consider why ITS methods have not been exploited. Some of the problems and opportunities for training for Mars missions are examined, including how using robots in exploration activities will help but raise new training problems. These ideas will be illustrated with examples from the BrahmsVE system in which a browser- based virtual reality display with avatars allows interacting with a distributed multiagent system, in which agents can be people, robots, or software programs. Using BrahmsVE may provide a way for astronauts to interact with

  15. RNA-Guided Activation of Pluripotency Genes in Human Fibroblasts

    DEFF Research Database (Denmark)

    Xiong, Kai; Zhou, Yan; Blichfeld, Kristian Aabo

    2017-01-01

    -associated protein 9 (dCas9)-VP64 (CRISPRa) alone, or a combination of dCas9-VP64 and MS2-P65-HSF1 [synergistic activation mediator (SAM) system] mediated activation of five pluripotency genes: KLF4 (K), LIN28 (L), MYC (M), OCT4 (O), and SOX2 (S) in human cells (HEK293T, HeLa, HepG2, and primary fibroblasts...... could be obtained from these SAM fibroblasts. In conclusion, our study showed that CRISPR/Cas9-based ATFs are potent to activate and maintain transcription of endogenous human pluripotent genes. However, future improvements of the system are still required to improve activation efficiency and cellular...

  16. Barriers for recess physical activity: a gender specific qualitative focus group exploration.

    Science.gov (United States)

    Pawlowski, Charlotte Skau; Tjørnhøj-Thomsen, Tine; Schipperijn, Jasper; Troelsen, Jens

    2014-06-23

    Many children, in particular girls, do not reach the recommended amount of daily physical activity. School recess provides an opportunity for both boys and girls to be physically active, but barriers to recess physical activity are not well understood. This study explores gender differences in children's perceptions of barriers to recess physical activity. Based on the socio-ecological model four types of environmental barriers were distinguished: natural, social, physical and organizational environment. Data were collected through 17 focus groups (at 17 different schools) with in total 111 children (53 boys) from fourth grade, with a mean age of 10.4 years. The focus groups included an open group discussion, go-along group interviews, and a gender segregated post-it note activity. A content analysis of the post-it notes was used to rank the children's perceived barriers. This was verified by a thematic analysis of transcripts from the open discussions and go-along interviews. The most frequently identified barriers for both boys and girls were weather, conflicts, lack of space, lack of play facilities and a newly-found barrier, use of electronic devices. While boys and girls identified the same barriers, there were both inter- and intra-gender differences in the perception of these barriers. Weather was a barrier for all children, apart from the most active boys. Conflicts were perceived as a barrier particularly by those boys who played ballgames. Girls said they would like to have more secluded areas added to the school playground, even in large schoolyards where lack of space was not a barrier. This aligned with girls' requests for more "hanging-out" facilities, whereas boys primarily wanted activity promoting facilities. Based on the results from this study, we recommend promoting recess physical activity through a combination of actions, addressing barriers within the natural, social, physical and organizational environment.

  17. Exploring ultrashort high-energy electron-induced damage in human carcinoma cells

    International Nuclear Information System (INIS)

    Rigaud, O.; Fortunel, N.O.; Vaigot, P.; Cadio, E.; Martin, M.T.; Lundh, O.; Faure, J.; Rechatin, C.; Malka, V.; Gauduel, Y.A.

    2010-01-01

    In conventional cancer therapy or fundamental radiobiology research, the accumulated knowledge on the complex responses of healthy or diseased cells to ionizing radiation is generally obtained with low-dose rates. Under these radiation conditions, the time spent for energy deposition is very long compared with the dynamics of early molecular and cellular responses. The use of ultrashort pulsed radiation would offer new perspectives for exploring the 'black box' aspects of long irradiation profiles and favouring the selective control of early damage in living targets. Several attempts were previously performed using nanosecond or picosecond pulsed irradiations on various mammalian cells and radiosensitive mutants at high dose rate. The effects of single or multi-pulsed radiations on cell populations were generally analyzed in the framework of dose survival curves or characterized by 2D imaging of γ-H2AX foci and no increase in cytotoxicity was shown compared with a delivery at a conventional dose rate. Moreover, when multi-shot irradiations were performed, the overall time needed to obtain an integrated dose of several Grays again overlapped with the multi-scale dynamics of bio-molecular damage-repair sequences and cell signalling steps. Ideally, a single-shot irradiation delivering a well-defined energy profile, via a very short temporal window, would permit the approach of a real-time investigation of early radiation induced molecular damage within the confined spaces of cell compartments. Owing to the potential applications of intense ultrashort laser for radiation therapy, the model of the A431 carcinoma cell line was chosen. An ultrafast single-shot irradiation strategy was carried out with these radio-resistant human skin carcinoma cells, using the capacity of an innovating laser-plasma accelerator to generate quasi mono-energetic femtosecond electron bunches in the MeV domain and to deliver a very high dose rate of 10 13 Gy s -1 per pulse. The alkaline comet

  18. Solution XAS Analysis for Exploring the Active Species in Homogeneous Vanadium Complex Catalysis

    Science.gov (United States)

    Nomura, Kotohiro; Mitsudome, Takato; Tsutsumi, Ken; Yamazoe, Seiji

    2018-06-01

    Selected examples in V K-edge X-ray Absorption Near Edge Structure (XANES) analysis of a series of vanadium complexes containing imido ligands (possessing metal-nitrogen double bond) in toluene solution have been introduced, and their pre-edge and the edge were affected by their structures and nature of ligands. Selected results in exploring the oxidation states of the active species in ethylene dimerization/polymerization using homogeneous vanadium catalysts [consisting of (imido)vanadium(V) complexes and Al cocatalysts] by X-ray absorption spectroscopy (XAS) analyses have been introduced. It has been demonstrated that the method should provide more clear information concerning the active species in situ, especially by combination with the other methods (NMR and ESR spectra, X-ray crystallographic analysis, and reaction chemistry), and should be powerful tool for study of catalysis mechanism as well as for the structural analysis in solution.

  19. Environmental policy and regulation for oil exploration and shipping activities in the Barents Sea

    International Nuclear Information System (INIS)

    Futsaeter, G.

    1994-01-01

    The Barents Ses has one of the highest levels of biological production of all the world's oceans, and holds some of the largest fish stocks and concentrations of seabirds. Environmental conditions in the area make it particularly vulnerable to damage from human activities. The Norwegian Pollution Control Authority gives priority to preventive measures that can lower the probability of accidents and particular emphasis will be given to conditions attached to production licenses and controls on activities in areas that have not yet been opened for petroleum activities. Within the Arctic Environmental Protection Strategy (the Rovaniemi-process), Norway has proposed that efforts should be made to improve the protection of Arctic marine areas, and further that a working group including representatives of all the Arctic countries should assess various legal instruments and possible measures, and make recommendations for action. (author)

  20. An Exploration of Developing Active Exploring and Problem Solving Skill Lego Robot Course by the Application of Anchored Instruction Theory

    Science.gov (United States)

    Chen, Chen-Yuan

    2013-01-01

    In recent years, researches had shown that the development of problem solving skill became important for education, and the educational robots are capable for promoting students not only understand the physical and mathematical concepts, but also have active and constructive learning. Meanwhile, the importance of situation in education is rising,…

  1. Editorial of the Special Issue on Human-Technology Interaction and Technology Adoption: Exploring Frameworks other than Actor-Network Theory

    DEFF Research Database (Denmark)

    Tanev, Stoyan

    2014-01-01

    Actor-network theory (ANT) has established itself as a valuable resource for the analysis of technology innovation and adoption. One of the main reasons for the success of the Innovation Translation Model (a specific instantiation of ANT) is the fact that it fits very well the emerging dominance...... challenges. This is why in this special issue we have focused on exploring, in parallel to ANT, other approaches that have also proven valuable in studying technology adoption and human-technology interaction. Some of these approaches share significant common ground with ANT. They also diverge in some......, Design in-use, Practice theory, Innovation diffusion, Consumer innovativeness and Activity theory....

  2. Student-Produced Podcasts in Language Learning – Exploring Student Perceptions of Podcast Activities

    Directory of Open Access Journals (Sweden)

    Birgit Phillips

    2017-12-01

    Full Text Available Podcasts are a useful tool for developing speaking skills in language acquisition settings, particularly within the context of the emerging Mobile Assisted Language Learning (MALL. While much research has emphasized the effectiveness of teacher-produced podcasts, this study seeks to address the gap in knowledge on student-generated podcasts in language learning. In addition to highlighting some of the main pedagogical considerations of using podcasts in language learning, this paper explores students’ perceptions of podcasts as a learning tool. To this end, this study describes the results of two surveys which were conducted with two different student cohorts over the course of two years. The surveys explored the students’ levels of acceptance and enjoyment of activities in which they had to produce their own podcasts, as well as the perceived learning benefits. The discussion section describes a range of positive learning outcomes and highlights the pedagogical implications of using podcasts in class. The paper concludes with some practical suggestions for the effective use of student-generated podcast activities in the language classroom.

  3. Exploring Perceptions of Barriers, Facilitators, and Motivators to Physical Activity Among Female Bariatric Patients: Implications for Physical Activity Programming.

    Science.gov (United States)

    Dikareva, A; Harvey, W J; Cicchillitti, M A; Bartlett, S J; Andersen, R E

    2016-09-01

    To explore barriers, facilitators, and motivators to adopting and maintaining regular physical activity among women with obesity who have undergone bariatric surgery. Individual interviews with women 3 to 24 months post-bariatric surgery. Participants were recruited from a bariatric clinic in Montreal, Canada. Twelve women were recruited (mean age = 47 ± 9 years) using poster advertisements and word of mouth. Participants were on average 15 months postsurgery. Each woman was interviewed once using a semistructured interview protocol. Recruitment was conducted until data saturation (i.e., no new information emerged). The interviews were transcribed, coded, and analyzed using inductive thematic analysis. Three interrelated themes emerged: the physical body, appraisal of the physical and social self, and the exercise environment. Barriers included weight-restricted mobility, side effects of surgery, body dissatisfaction, compromised psychological health, competing responsibilities, a lack of exercise self-efficacy and social support, reduced access to accommodating facilities, lack of exercise knowledge, and northern climate. Participants reported postsurgical weight loss, weight and health maintenance, enjoyment, body image, and supportive active relationships, as well as access to accommodating facilities and exercise knowledge, as facilitators and motivators. Suggested physical activity programming strategies for health care professionals working with this unique population are discussed. Physical activity and health promotion initiatives can also benefit from a cultural paradigm shift away from weight-based representations of health. © 2016 by American Journal of Health Promotion, Inc.

  4. The significance of human factors in nuclear activities

    International Nuclear Information System (INIS)

    Weil, L.; Berg, H.P.

    1999-01-01

    Human factors is an aspect increasingly investigated in the last few years in efforts and programmes for enhancing the operational safety of nuclear systems. Methodology has been elaborated for analysis and evaluation of human reliability, or development of instruments supporting the decisions to be taken by the operators at the man-control room interface of nuclear installations, as well as initial approaches to introduce organisational factors which may influence the man-machine function allocation, and thus are an element of the safety culture concept. The significance of human factors in nuclear activities, as well as activities at the national and international level for optimisation of the man-machine interface and the man-organisation interface are discussed. (orig./CB) [de

  5. Towards discrete wavelet transform-based human activity recognition

    Science.gov (United States)

    Khare, Manish; Jeon, Moongu

    2017-06-01

    Providing accurate recognition of human activities is a challenging problem for visual surveillance applications. In this paper, we present a simple and efficient algorithm for human activity recognition based on a wavelet transform. We adopt discrete wavelet transform (DWT) coefficients as a feature of human objects to obtain advantages of its multiresolution approach. The proposed method is tested on multiple levels of DWT. Experiments are carried out on different standard action datasets including KTH and i3D Post. The proposed method is compared with other state-of-the-art methods in terms of different quantitative performance measures. The proposed method is found to have better recognition accuracy in comparison to the state-of-the-art methods.

  6. Qualitative study exploring healthy eating practices and physical activity among adolescent girls in rural South Africa.

    Science.gov (United States)

    Sedibe, Heather M; Kahn, Kathleen; Edin, Kerstin; Gitau, Tabitha; Ivarsson, Anneli; Norris, Shane A

    2014-08-26

    Dietary behaviours and physical activity are modifiable risk factors to address increasing levels of obesity among children and adolescents, and consequently to reduce later cardiovascular and metabolic disease. This paper explores perceptions, attitudes, barriers, and facilitators related to healthy eating and physical activity among adolescent girls in rural South Africa. A qualitative study was conducted in the rural Agincourt subdistrict, covered by a health and sociodemographic surveillance system, in Mpumalanga province, South Africa. Semistructured "duo-interviews" were carried out with 11 pairs of adolescent female friends aged 16 to 19 years. Thematic content analysis was used. The majority of participants considered locally grown and traditional foods, especially fruits and vegetables, to be healthy. Their consumption was limited by availability, and these foods were often sourced from family or neighbourhood gardens. Female caregivers and school meal programmes facilitated healthy eating practices. Most participants believed in the importance of breakfast, even though for the majority, limited food within the household was a barrier to eating breakfast before going to school. The majority cited limited accessibility as a major barrier to healthy eating, and noted the increasing intake of "convenient and less healthy foods". Girls were aware of the benefits of physical activity and engaged in various physical activities within the home, community, and schools, including household chores, walking long distances to school, traditional dancing, and extramural activities such as netball and soccer. The findings show widespread knowledge about healthy eating and the benefits of consuming locally grown and traditional food items in a population that is undergoing nutrition transition. Limited access and food availability are strong barriers to healthy eating practices. School meal programmes are an important facilitator of healthy eating, and breakfast

  7. Impact Of Human Activities On Ecosystem In Rivers State, Nigeria ...

    African Journals Online (AJOL)

    This study was to assess the percent sample population size of people involved in selected human economic activities and the impact on ecosystem in Rivers State. The data for this study was obtained from a sample size of 1000 respondents who were purposively selected from the study area. Purposive sample was used ...

  8. Relating Eye Activity Measures to Human Controller Remnant Characteristics

    NARCIS (Netherlands)

    Popovici, A; Zaal, P.M.T.; Pool, D.M.; Mulder, M.; Sawaragi, T

    2016-01-01

    This study attempts to partially explain the characteristics of the human perceptual remnant, following Levison’s representation of the remnant as an equivalent observation noise. Eye activity parameters are recorded using an eye tracker in two compensatory tracking tasks in which the visual

  9. Human Activity Recognition Using Hierarchically-Mined Feature Constellations

    NARCIS (Netherlands)

    Oikonomopoulos, A.; Pantic, Maja

    In this paper we address the problem of human activity modelling and recognition by means of a hierarchical representation of mined dense spatiotemporal features. At each level of the hierarchy, the proposed method selects feature constellations that are increasingly discriminative and

  10. Focus-of-attention for human activity recognition from UAVs

    NARCIS (Netherlands)

    Burghouts, G.J.; Eekeren, A.W.M. van; Dijk, J.

    2014-01-01

    This paper presents a system to extract metadata about human activities from full-motion video recorded from a UAV. The pipeline consists of these components: tracking, motion features, representation of the tracks in terms of their motion features, and classification of each track as one of the

  11. Tactile interactions activate mirror system regions in the human brain.

    Science.gov (United States)

    McKyton, Ayelet

    2011-12-07

    Communicating with others is essential for the development of a society. Although types of communications, such as language and visual gestures, were thoroughly investigated in the past, little research has been done to investigate interactions through touch. To study this we used functional magnetic resonance imaging. Twelve participants were scanned with their eyes covered while stroking four kinds of items, representing different somatosensory stimuli: a human hand, a realistic rubber hand, an object, and a simple texture. Although the human and the rubber hands had the same overall shape, in three regions there was significantly more blood oxygen level dependent activation when touching the real hand: the anterior medial prefrontal cortex, the ventral premotor cortex, and the posterior superior temporal cortex. The last two regions are part of the mirror network and are known to be activated through visual interactions such as gestures. Interestingly, in this study, these areas were activated through a somatosensory interaction. A control experiment was performed to eliminate confounds of temperature, texture, and imagery, suggesting that the activation in these areas was correlated with the touch of a human hand. These results reveal the neuronal network working behind human tactile interactions, and highlight the participation of the mirror system in such functions.

  12. Activation of the lectin complement pathway on human renal ...

    African Journals Online (AJOL)

    This study aimed to investigate the roles of high glucose and mannose-binding lectin (MBL) on the activation of the lectin complement pathway (LCP) on human renal glomerular endothelial cells (HRGECs) in vitro. Flow cytometry analysis, immunofluorescence staining and Western blot were used to detect the cell surface ...

  13. Linguistic Human Rights Discourse in Deaf Community Activism

    Science.gov (United States)

    Murray, Joseph J.

    2015-01-01

    The past three decades of activism for linguistic human rights (Skutnabb-Kangas 2000) have witnessed examples of language planning by various national and supranational actors in national and international spaces, with an exchange of ideas and strategies employed by national, regional, and worldwide organizations. In many countries a key goal of…

  14. Activation of human T lymphocytes by Leishmania lipophosphoglycan

    DEFF Research Database (Denmark)

    Kemp, M; Theander, T G; Handman, E

    1991-01-01

    This study describes Leishmania antigen-induced activation of lymphocytes isolated from Kenyan donors, previously treated for visceral leishmaniasis, and from Danish and Kenyan controls. Peripheral blood mononuclear cells (PBMC) from cured Kala-Azar patients proliferated and produced Interferon......, the results suggest that human T lymphocytes can respond to glycolipid antigens....

  15. Activation of the insular cortex during dynamic exercise in humans

    DEFF Research Database (Denmark)

    Williamson, James; Nobrega, A C; McColl, R

    1997-01-01

    role as a site for regulation of autonomic activity. 2. Eight subjects were studied during voluntary active cycling and passively induced cycling. Additionally, four of the subjects underwent passive movement combined with electrical stimulation of the legs. 3. Increases in regional cerebral blood flow...... during active, but not passive cycling. There were no significant changes in rCBF for the right insula. Also, the magnitude of rCBF increase for leg primary motor areas was significantly greater for both active cycling and passive cycling combined with electrical stimulation compared with passive cycling...... alone. 5. These findings provide the first evidence of insular activation during dynamic exercise in humans, suggesting that the left insular cortex may serve as a site for cortical regulation of cardiac autonomic (parasympathetic) activity. Additionally, findings during passive cycling with electrical...

  16. Quantitative PET of human urokinase-type plasminogen activator receptor with 64Cu-DOTA-AE105

    DEFF Research Database (Denmark)

    Persson, Morten; Madsen, Jacob; Østergaard, Søren

    2012-01-01

    Expression levels of the urokinase-type plasminogen activator receptor (uPAR) represent an established biomarker for poor prognosis in a variety of human cancers. The objective of the present study was to explore whether noninvasive PET can be used to perform a quantitative assessment of expressi...

  17. Planetary Science Training for NASA's Astronauts: Preparing for Future Human Planetary Exploration

    Science.gov (United States)

    Bleacher, J. E.; Evans, C. A.; Graff, T. G.; Young, K. E.; Zeigler, R.

    2017-02-01

    Astronauts selected in 2017 and in future years will carry out in situ planetary science research during exploration of the solar system. Training to enable this goal is underway and is flexible to accommodate an evolving planetary science vision.

  18. Exploring the potential relevance of human-specific genes to complex disease

    Directory of Open Access Journals (Sweden)

    Cooper David N

    2011-01-01

    Full Text Available Abstract Although human disease genes generally tend to be evolutionarily more ancient than non-disease genes, complex disease genes appear to be represented more frequently than Mendelian disease genes among genes of more recent evolutionary origin. It is therefore proposed that the analysis of human-specific genes might provide new insights into the genetics of complex disease. Cross-comparison with the Human Gene Mutation Database (http://www.hgmd.org revealed a number of examples of disease-causing and disease-associated mutations in putatively human-specific genes. A sizeable proportion of these were missense polymorphisms associated with complex disease. Since both human-specific genes and genes associated with complex disease have often experienced particularly rapid rates of evolutionary change, either due to weaker purifying selection or positive selection, it is proposed that a significant number of human-specific genes may play a role in complex disease.

  19. Human Exploration System Test-Bed for Integration and Advancement (HESTIA) Support of Future NASA Deep-Space Missions

    Science.gov (United States)

    Marmolejo, Jose; Ewert, Michael

    2016-01-01

    The Engineering Directorate at the NASA - Johnson Space Center is outfitting a 20-Foot diameter hypobaric chamber in Building 7 to support future deep-space Environmental Control & Life Support System (ECLSS) research as part of the Human Exploration System Test-bed for Integration and Advancement (HESTIA) Project. This human-rated chamber is the only NASA facility that has the unique experience, chamber geometry, infrastructure, and support systems capable of conducting this research. The chamber was used to support Gemini, Apollo, and SkyLab Missions. More recently, it was used to conduct 30-, 60-, and 90-day human ECLSS closed-loop testing in the 1990s to support the International Space Station and life support technology development. NASA studies show that both planetary surface and deep-space transit crew habitats will be 3-4 story cylindrical structures driven by human occupancy volumetric needs and launch vehicle constraints. The HESTIA facility offers a 3-story, 20-foot diameter habitat consistent with the studies' recommendations. HESTIA operations follow stringent processes by a certified test team that including human testing. Project management, analysis, design, acquisition, fabrication, assembly and certification of facility build-ups are available to support this research. HESTIA offers close proximity to key stakeholders including astronauts, Human Research Program (who direct space human research for the agency), Mission Operations, Safety & Mission Assurance, and Engineering Directorate. The HESTIA chamber can operate at reduced pressure and elevated oxygen environments including those proposed for deep-space exploration. Data acquisition, power, fluids and other facility resources are available to support a wide range of research. Recently completed HESTIA research consisted of unmanned testing of ECLSS technologies. Eventually, the HESTIA research will include humans for extended durations at reduced pressure and elevated oxygen to demonstrate

  20. Human Error Probability Assessment During Maintenance Activities of Marine Systems

    Directory of Open Access Journals (Sweden)

    Rabiul Islam

    2018-03-01

    Full Text Available Background: Maintenance operations on-board ships are highly demanding. Maintenance operations are intensive activities requiring high man–machine interactions in challenging and evolving conditions. The evolving conditions are weather conditions, workplace temperature, ship motion, noise and vibration, and workload and stress. For example, extreme weather condition affects seafarers' performance, increasing the chances of error, and, consequently, can cause injuries or fatalities to personnel. An effective human error probability model is required to better manage maintenance on-board ships. The developed model would assist in developing and maintaining effective risk management protocols. Thus, the objective of this study is to develop a human error probability model considering various internal and external factors affecting seafarers' performance. Methods: The human error probability model is developed using probability theory applied to Bayesian network. The model is tested using the data received through the developed questionnaire survey of >200 experienced seafarers with >5 years of experience. The model developed in this study is used to find out the reliability of human performance on particular maintenance activities. Results: The developed methodology is tested on the maintenance of marine engine's cooling water pump for engine department and anchor windlass for deck department. In the considered case studies, human error probabilities are estimated in various scenarios and the results are compared between the scenarios and the different seafarer categories. The results of the case studies for both departments are also compared. Conclusion: The developed model is effective in assessing human error probabilities. These probabilities would get dynamically updated as and when new information is available on changes in either internal (i.e., training, experience, and fatigue or external (i.e., environmental and operational conditions