WorldWideScience

Sample records for human 60-kda ro

  1. Transfection, overexpression and clinical application of human 60 kDa Ro/SSA autoantigens in HEp-2 cells

    Institute of Scientific and Technical Information of China (English)

    吕良敬; 陈顺乐; 顾越英; 沈南; 鲍春德; 王元; 薛峰; 叶萍; 俞翀曌

    2003-01-01

    Objective To develop an improved substrate for indirect immunofluorescence test (IIF) for detecting anti-Ro60/Sjogren's syndrome A (Ro/SSA) autoantibodies.Methods 60-kDa Ro/SSA autoantigens (Ro60) cDNAs were obtained from human placental cDNA library using polymerase chain reaction (PCR) and were cloned into the mammalian expression vector-pEGFP-C1. Then, the recombinant plasmids were transfected into HEp-2 cells. We confirmed the overexpression, localization and antigenicity of fusion proteins in transfected cells by means of immunoblotting, confocal fluorescence microscopy and IIF. HEp-2 and HEp-Ro60 were analyzed by IIF using a panel of 10 precipitin-positive anti-Ro human sera simultaneously.Results Stable expression of Ro60-green fluorescent protein (Ro60-GFP) fusion proteins were maintained ten more generations. Ro60-GFP kept the antigenicity of Ro while demonstrating its own characteristic immunofluorescent pattern in HEp-Ro60 cells. The transfectants dramatically increased the sensitivity of IIF testing (a mean increase of 6.7-fold in endpoint titer). Eight overten (8/10) positive anti-Ro sera showed characteristic immunofluorescent patterns for HEp-Ro60, including two sera that were anti-nuclear antibodies (ANA) negative for untransfected HEp-2. IIF-ANA in all healthy sera was negative for HEp-Ro60. Conclusions As a new substrate for IIF, the Ro60 transfectants can be used to detect anti-Ro antibodies. In addition, transfected HEp-2 cells keep the immunofluorescent properties of HEp-2 cells in IIF-ANA tests and can be employed as a substrate for routine IIF-ANA detection.

  2. The human long non-coding RNA-RoR is a p53 repressor in response to DNA damage

    Institute of Scientific and Technical Information of China (English)

    Ali Zhang; Nanjiang Zhou; Jianguo Huang; Qian Liu; Koji Fukuda; Ding Ma; Zhaohui Lu

    2013-01-01

    It is well known that upon stress,the level of the tumor suppressor p53 is remarkably elevated.However,despite extensive studies,the underlying mechanism involving important inter-players for stress-induced p53 regulation is still not fully understood.We present evidence that the human lincRNA-RoR (RoR) is a strong negative regulator of p53.Unlike MDM2 that causes p53 degradation through the ubiquitin-proteasome pathway,RoR suppresses p53 translation through direct interaction with the heterogeneous nuclear ribonucleoprotein I (hnRNP I).Importantly,a 28-base RoR sequence carrying hnRNP I binding motifs is essential and sufficient for p53 repression.We further show that RoR inhibits p53-mediated cell cycle arrest and apoptosis.Finally,we demonstrate a RoR-p53 autoregulatory feedback loop where p53 transcriptionally induces RoR expression.Together,these results suggest that the RoR-hnRNP I-p53 axis may constitute an additional surveillance network for the cell to better respond to various stresses.

  3. 60 kD Ro and nRNP A frequently initiate human lupus autoimmunity.

    Science.gov (United States)

    Heinlen, Latisha D; McClain, Micah T; Ritterhouse, Lauren L; Bruner, Benjamin F; Edgerton, Colin C; Keith, Michael P; James, Judith A; Harley, John B

    2010-03-10

    Systemic lupus erythematosus (SLE) is a clinically heterogeneous, humoral autoimmune disorder. The unifying feature among SLE patients is the production of large quantities of autoantibodies. Serum samples from 129 patients collected before the onset of SLE and while in the United States military were evaluated for early pre-clinical serologic events. The first available positive serum sample frequently already contained multiple autoantibody specificities (65%). However, in 34 SLE patients the earliest pre-clinical serum sample positive for any detectable common autoantibody bound only a single autoantigen, most commonly 60 kD Ro (29%), nRNP A (24%), anti-phospholipids (18%) or rheumatoid factor (15%). We identified several recurrent patterns of autoantibody onset using these pre-diagnostic samples. In the serum samples available, anti-nRNP A appeared before or simultaneously with anti-nRNP 70 K in 96% of the patients who had both autoantibodies at diagnosis. Anti-60 kD Ro antibodies appeared before or simultaneously with anti-La (98%) or anti-52 kD Ro (95%). The autoantibody response in SLE patients begins simply, often binding a single specific autoantigen years before disease onset, followed by epitope spreading to additional autoantigenic specificities that are accrued in recurring patterns.

  4. The mapping of the human 52-kD Ro/SSA autoantigen gene to human chromosome II, and its polymorphisms

    Energy Technology Data Exchange (ETDEWEB)

    Frank, M.B.; Itoh, Kazuko (Oklahoma Medical Research Foundation, Oklahoma City (United States)); Fujisaku, Atsushi (Hokkaido Univ., Sapporo (Japan)); Pontarotti, P. (Centre de Recherches sur le Polymorphisme Genetique des Populations Humaines, Toulouse (France)); Mattei, M.G. (INSERM U 242, Marseille (France)); Neas, B.R. (Oklahoma Medical Research Foundation, Oklahoma City (United States) Univ. of Oklahoma, Oklahoma City (United States))

    1993-01-01

    Autoantibodies to the ribonucleoprotein Ro/SSA occur in nearly half of the patients with systemic lupus erythematosus and are associated with lymphopenia, photosensitive dermatitis, and pulmonary and renal disease, which suggests that they have an immunopathologic role. The majority of Ro/SSA precipitin-positive patients produce serum antibodies that bind to the 60-kD and 52-kD Ro/SSA proteins. The authors previously isolated and determined the nucleotide sequence of a cDNA clone that encodes the 52-kD form of the human Ro/SSA protein. In the present study, they have determined the chromosomal location of the gene by in situ hybridization to the end of the short arm of chromosome 11. Hybridization of portions of the cDNA probe to restriction enzyme-digested DNA indicated the gene is composed of at least three exons. The exon encoding the putative zinc fingers of this protein was found to be distinct from that which encodes the leucine zipper. An RFLP of this gene was identified and is associated with the presence of lupus, primarily in black Americans. 60 refs., 3 figs., 3 tabs.

  5. Pharmacokinetic Modeling and Monte Carlo Simulation to Predict Interindividual Variability in Human Exposure to Oseltamivir and Its Active Metabolite, Ro 64-0802.

    Science.gov (United States)

    Ito, Mototsugu; Kusuhara, Hiroyuki; Ose, Atsushi; Kondo, Tsunenori; Tanabe, Kazunari; Nakayama, Hideki; Horita, Shigeru; Fujita, Takuya; Sugiyama, Yuichi

    2017-01-01

    Oseltamivir (Tamiflu®) is a prodrug of Ro 64-0802, a selective inhibitor of influenza virus neuraminidase. There is a possible relationship between oseltamivir treatment and neuropsychiatric adverse events; although this has not been established, close monitoring is recommended on the prescription label. The objective of this study was to predict interindividual variability of human exposure to oseltamivir and its active metabolite Ro 64-0802. By leveraging mathematical models and computations, physiological parameters in virtual subjects were generated with population means and coefficient of variations collected from the literature or produced experimentally. Postulated functional changes caused by genetic mutations in four key molecules, carboxylesterase 1A1, P-glycoprotein, organic anion transporter 3, and multidrug resistance-associated protein 4, were also taken into account. One hundred thousand virtual subjects were generated per simulation, which was iterated 20 times with different random number generator seeds. Even in the most exaggerated case, the systemic areas under the concentration-time curve (AUCs) of oseltamivir and Ro 64-0802 were increased by at most threefold compared with the population mean. By contrast, the brain AUCs of oseltamivir and Ro 64-0802 were increased up to about sevenfold and 40-fold, respectively, compared with the population means. This unexpectedly high exposure to oseltamivir or Ro 64-0802, which occurs extremely rarely, might trigger adverse central nervous system effects in the clinical setting.

  6. Activated human CD4+CD45RO+ memory T-cells indirectly inhibit NLRP3 inflammasome activation through downregulation of P2X7R signalling.

    Directory of Open Access Journals (Sweden)

    Vanessa Beynon

    Full Text Available Inflammasomes are multi-protein complexes that control the production of pro-inflammatory cytokines such as IL-1β. Inflammasomes play an important role in the control of immunity to tumors and infections, and also in autoimmune diseases, but the mechanisms controlling the activation of human inflammasomes are largely unknown. We found that human activated CD4+CD45RO+ memory T-cells specifically suppress P2X7R-mediated NLRP3 inflammasome activation, without affecting P2X7R-independent NLRP3 or NLRP1 inflammasome activation. The concomitant increase in pro-IL-1β production induced by activated memory T-cells concealed this effect. Priming with IFNβ decreased pro-IL-1β production in addition to NLRP3 inflammasome inhibition and thus unmasked the inhibitory effect on NLRP3 inflammasome activation. IFNβ suppresses NLRP3 inflammasome activation through an indirect mechanism involving decreased P2X7R signaling. The inhibition of pro-IL-1β production and suppression of NLRP3 inflammasome activation by IFNβ-primed human CD4+CD45RO+ memory T-cells is partly mediated by soluble FasL and is associated with down-regulated P2X7R mRNA expression and reduced response to ATP in monocytes. CD4+CD45RO+ memory T-cells from multiple sclerosis (MS patients showed a reduced ability to suppress NLRP3 inflammasome activation, however their suppressive ability was recovered following in vivo treatment with IFNβ. Thus, our data demonstrate that human P2X7R-mediated NLRP3 inflammasome activation is regulated by activated CD4+CD45RO+ memory T cells, and provide new information on the mechanisms mediating the therapeutic effects of IFNβ in MS.

  7. RoMo

    DEFF Research Database (Denmark)

    Pedersen, Esben Warming; Hornbæk, Kasper

    2011-01-01

    In TUIs, physical/digital conflicts can occur when the digital model does not match the model implied by the spatial lay- out of tangibles. We show how tangible tabletop interfaces (TTI) can be modified to allow robot movement of tangi- bles, thereby avoiding conflicts. We present RoMo, an open...

  8. Inhibitory Effects of Cytosolic Ca2+ Concentration by Ginsenoside Ro Are Dependent on Phosphorylation of IP3RI and Dephosphorylation of ERK in Human Platelets

    Directory of Open Access Journals (Sweden)

    Hyuk-Woo Kwon

    2015-01-01

    Full Text Available Intracellular Ca2+ ([Ca2+]i is platelet aggregation-inducing molecule and is involved in activation of aggregation associated molecules. This study was carried out to understand the Ca2+-antagonistic effect of ginsenoside Ro (G-Ro, an oleanane-type saponin in Panax ginseng. G-Ro, without affecting leakage of lactate dehydrogenase, dose-dependently inhibited thrombin-induced platelet aggregation, and the half maximal inhibitory concentration was approximately 155 μM. G-Ro inhibited strongly thrombin-elevated [Ca2+]i, which was strongly increased by A-kinase inhibitor Rp-8-Br-cAMPS compared to G-kinase inhibitor Rp-8-Br-cGMPS. G-Ro increased the level of cAMP and subsequently elevated the phosphorylation of inositol 1, 4, 5-triphosphate receptor I (IP3RI (Ser1756 to inhibit [Ca2+]i mobilization in thrombin-induced platelet aggregation. Phosphorylation of IP3RI (Ser1756 by G-Ro was decreased by PKA inhibitor Rp-8-Br-cAMPS. In addition, G-Ro inhibited thrombin-induced phosphorylation of ERK 2 (42 kDa, indicating inhibition of Ca2+ influx across plasma membrane. We demonstrate that G-Ro upregulates cAMP-dependent IP3RI (Ser1756 phosphorylation and downregulates phosphorylation of ERK 2 (42 kDa to decrease thrombin-elevated [Ca2+]i, which contributes to inhibition of ATP and serotonin release, and p-selectin expression. These results indicate that G-Ro in Panax ginseng is a beneficial novel Ca2+-antagonistic compound and may prevent platelet aggregation-mediated thrombotic disease.

  9. Ultraviolet radiation (UVR) induces cell-surface Ro/SSA antigen expression by human keratinocytes in vitro: a possible mechanism for the UVR induction of cutaneous lupus lesions

    Energy Technology Data Exchange (ETDEWEB)

    Jones, S.K. (Bristol Royal Infirmary (United Kingdom))

    1992-06-01

    Antinuclear antibodies are useful markers of connective tissue disease. In this study, UVB but not UVA induced the expression of Ro/SSA antigen on keratinocyte surfaces in vitro. This expression was also found with the extractable nuclear antigens RnP and Sm, but not with single or double-stranded DNA. The expression was prevented by blocking protein synthesis, suggesting that it was an active process. The results suggest that UVB exposure may result in the expression of Ro/SSA antigen on the surfaces of basal keratinocytes in vivo. This antigen could then bind circulating antibody leading to the cutaneous lesions in neonatal and subacute cutaneous lupus erythematosus. (Author).

  10. Binding of antibodies to the extractable nuclear antigens SS-A/Ro and SS-B/La is induced on the surface of human keratinocytes by ultraviolet light (UVL): Implications for the pathogenesis of photosensitive cutaneous lupus

    Energy Technology Data Exchange (ETDEWEB)

    Furukawa, F.; Kashihara-Sawami, M.; Lyons, M.B.; Norris, D.A. (Univ. of Colorado School of Medicine, Denver (USA))

    1990-01-01

    Autoantibodies to the non-histone nucleoprotein antigens SS-A/Ro, SS-B/La, and RNP are highly associated with photosensitive cutaneous lupus erythematosus (LE). In order to better understand the potential mechanisms of ultraviolet (UV) light on photosensitivity in patients with cutaneous LE, we designed immunopathologic in vitro and in vivo experiments to evaluate the effects of UV on the binding of such autoantibodies to the surface of human keratinocytes, one major target of immunologic damage in photosensitive LE. Short-term 2% paraformaldehyde fixation of suspensions of cultured human keratinocytes previously incubated with monospecific antiserum probes enabled the detection of ENA expression on the cell surface by flow-cytometry analysis. UVB light (280-320 nm) induced the binding of monospecific antibody probes for SS-A/Ro and SS-B/La on keratinocytes in a dose-dependent pattern with maximal induction observed at the dose of 200 mJ/cm2 UVB. Binding of SS-A/Ro, SS-B/La, and RNP antibody was augmented strongly, but binding of anti-Sm was very weak. In contrast, UVA (320-400 nm) light had no effect on the induction of binding of these antibody probes. Identical results were seen by standard immunofluorescence techniques. Hydroxyurea-treated keratinocytes showed similar induction of those antigens by UVB irradiation, which suggested that ENA expression on cultured keratinocytes by UVB were cell-cycle independent. Tunicamycin, an inhibitor of glycosylation of proteins, reduced UVB light effect on the SS-A/Ro and SS-B/La antigen's expression. These in vitro FACS analyses revealed that ENA augmentation on the keratinocyte cell surface was dose dependent, UVB dependent, glycosylation dependent, and cell-cycle independent. In vivo ENA augmentation on the keratinocyte surface was examined in suction blister epidermal roofs.

  11. Anti-Ro and anti-La autoantibodies induce TNF-α production by human salivary gland cells: an in vitro study

    Directory of Open Access Journals (Sweden)

    V. Mitolo

    2011-09-01

    Full Text Available Obiettivo: Lo scopo di questo studio è stato valutare la produzione di TNF-α, induttore della via estrinseca del processo apoptotico, in seguito al trattamento con gli autoanticorpi anti-Ro ed anti-La isolati da pazienti con sindrome di Sjögren primaria in un modello sperimentale rappresentato dalla linea cellulare di ghiandole salivari umane, A- 253. È stata, inoltre, valutata la presenza sulla superficie di tali cellule di recettori specifici per tale induttore, TNFR1 e TNFR2. Materiali e metodi: Gli autoanticorpi anti-La ed anti-Ro sono stati purificati su una colonna cromatografia ad alta affinità. Le metodiche utilizzate per la valutazione della produzione di TNF-α e lo studio dei recettori di superficie sono state immunofluorescenza, RT-PCR e saggi immunoenzimatici. Risultati: I nostri risultati hanno dimostrato che le cellule A-253 esprimono in superficie i recettori TNFR1 e TNFR2 e che gli autoanticorpi anti-Ro e anti-La sono in grado di indurre la produzione di TNF-α nelle stesse cellule. Conclusioni: Il trattamento con gli autoanticorpi anti-Ro ed anti-La induce la produzione di TNF-α in cellule di ghiandole salivari umane e questo potrebbe spiegare la attivazione della via estrinseca della apoptosi.

  12. CoRoTlog

    Science.gov (United States)

    Plasson, Ph.

    2006-11-01

    LESIA, in close cooperation with CNES, DLR and IWF, is responsible for the tests and validation of the CoRoT instrument digital process unit which is made up of the BEX and DPU assembly. The main part of the work has consisted in validating the DPU software and in testing the BEX/DPU coupling. This work took more than two years due to the central role of the software tested and its technical complexity. The first task, in the validation process, was to carry out the acceptance tests of the DPU software. These tests consisted in checking each of the 325 requirements identified in the URD (User Requirements Document) and were played in a configuration using the DPU coupled to a BEX simulator. During the acceptance tests, all the transversal functionalities of the DPU software, like the TC/TM management, the state machine management, the BEX driving, the system monitoring or the maintenance functionalities were checked in depth. The functionalities associated with the seismology and exoplanetology processing, like the loading of window and mask descriptors or the configuration of the service execution parameters, were also exhaustively tested. After having validated the DPU software against the user requirements using a BEX simulator, the following step consisted in coupling the DPU and the BEX in order to check that the formed unit worked correctly and met the performance requirements. These tests were conducted in two phases: the first one was devoted to the functional aspects and the tests of interface, the second one to the performance aspects. The performance tests were based on the use of the DPU software scientific services and on the use of full images representative of a realistic sky as inputs. These tests were also based on the use of a reference set of windows and parameters, which was provided by the scientific team and was representative, in terms of load and complexity, of the one that could be used during the observation mode of the CoRoT instrument

  13. Environmental Performance Evaluation of Ro-Ro Passenger Ferry Transportation

    DEFF Research Database (Denmark)

    Kristensen, Hans Otto Holmegaard; Hagemeister, Constantin

    2012-01-01

    With increasing focus on the environmental performance of different transport modes (for example trucks, trains, ships and aircraft) it is of utmost importance that the different transport modes are compared on an equal basis so that the environmental impact, defined as energy demand and....../or emissions per transport unit, is related to the same unit for the different transport forms. For Ro-Ro passenger ferries it can be difficult to find a suitable common transport unit, as they often transport a mix of cargo, such as passengers, passenger cars, trucks, lorries, busses and other rolling...... transport units. In this paper a method for determination of a common transport unit for Ro-Ro passenger ships will be described....

  14. Identification of biomarkers regulated by rexinoids (LGD1069, LG100268 and Ro25-7386) in human breast cells using Affymetrix microarray.

    Science.gov (United States)

    Seo, Hye-Sook; Woo, Jong-Kyu; Shin, Yong Cheol; Ko, Seong-Gyu

    2015-07-01

    Retinoids possess anti-proliferative properties, which suggests that they possess chemopreventive and therapeutic potential against cancer. In the current study, genes modulated by rexinoids (retinoid X receptor (RXR)-pan agonists, LGD1069 and LG100268; and the RXRα agonist, Ro25-7386) were identified using an Affymetrix microarray in normal and malignant breast cells. It was observed that LGD1069, LG100268 and Ro25-7386 suppressed the growth of breast cells. Secondly, several rexinoid-regulated genes were identified, which are involved in cell death, cell growth/maintenance, signal transduction and response to stimulus. These genes may be associated with the growth-suppressive activity of rexinoids. Therefore, the identified genes may serve as biomarkers and novel molecular targets for the prevention and treatment of breast cancer.

  15. The location of a disease-associated polymorphism and genomic structure of the human 52-kDa Ro/SSA locus (SSA1)

    Energy Technology Data Exchange (ETDEWEB)

    Tsugu, H.; Horowitz, R.; Gibson, N. [Univ. of Oklahoma Health Sciences Center, Oklahoma City, OK (United States)] [and others

    1994-12-01

    Sera from approximately 30% of patients with systemic lupus erythematosus (SLE) contain high titers of autoantibodies that bind to the 52-kDa Ro/SSA protein. We previously detected polymorphisms in the 52-kDa Ro/SSA gene (SSA1) with restriction enzymes, one of which is strongly associated with the presence of SLE (P < 0.0005) in African Americans. A higher disease frequency and more severe forms of the disease are commonly noted among these female patients. To determine the location and nature of this polymorphism, we obtained two clones that span 8.5 kb of the 52-kDa Ro/SSA locus including its upstream regulatory region. Six exons were identified, and their nucleotide sequences plus adjacent noncoding regions were determined. No differences were found between these exons and the coding region of one of the reported cDNAs. The disease-associated polymorphic site suggested by a restriction enzyme map and confirmed by DNA amplification and nucleotide sequencing was present upstream of exon 1. This polymorphism may be a genetic marker for a disease-related variation in the coding region for the protein or in the upstream regulatory region of this gene. Although this RFLP is present in Japanese, it is not associated with lupus in this race. 41 refs., 4 figs., 2 tabs.

  16. Argument ÜRO vastu / Joshua Muravchik

    Index Scriptorium Estoniae

    Muravchik, Joshua

    2004-01-01

    ÜRO rollist Somaalias, Rwandas ja Bosnias, Iisraeli eristaatusest. ÜRO silmakirjalikkusest inimõiguste alal, terrorismi legaliseerimisest, Kofi Annani juhtimisstiilist. Maailmas on pärast 1945. aastat valitsenud suhteline rahu mitte tänu ÜRO-le, vaid peamiselt USA tegevusele, leiab autor

  17. Turkish Ro-Ro Traffic in the Port of Trieste

    Directory of Open Access Journals (Sweden)

    Vittorio A. Torbianelli

    2012-10-01

    Full Text Available This article gives an economic and organisational analysis of the intermodal transport se1vice by means of Ro-Ro vessels between Turkey and central Europe through the port of Trieste.Many traits of this service are innovative, at least in the Mediterranean.To mention but a few: the geographical area it connects,the rapid geo-political evolution, the independent managingof the maritime route by a cons01tium of road transport companies, the use of combined road/ rail transport to reachthe European market, the air transfer of drivers, the transformationto the structure of the companies, etc. This service offersindeed a valuable example- not only because of its supeliorlogisticalefficiency compared to the road or container ship options-for the future of transport between Europe (in particularcentral- eastern European count1ies and the new markets inthe Levant, located behind the Eastern Mediterranean shores.

  18. A lupus-like syndrome develops in mice lacking the Ro 60-kDa protein, a major lupus autoantigen.

    Science.gov (United States)

    Xue, Dahai; Shi, Hong; Smith, James D; Chen, Xinguo; Noe, Dennis A; Cedervall, Tommy; Yang, Derek D; Eynon, Elizabeth; Brash, Douglas E; Kashgarian, Michael; Flavell, Richard A; Wolin, Sandra L

    2003-06-24

    Antibodies against a conserved RNA-binding protein, the Ro 60-kDa autoantigen, occur in 24-60% of all patients with systemic lupus erythematosus. Anti-Ro antibodies are correlated with photosensitivity and cutaneous lesions in these patients and with neonatal lupus, a syndrome in which mothers with anti-Ro antibodies give birth to children with complete congenital heart block and photosensitive skin lesions. In higher eukaryotes, the Ro protein binds small RNAs of unknown function known as Y RNAs. Because the Ro protein also binds misfolded 5S rRNA precursors, it is proposed to function in a quality-control pathway for ribosome biogenesis. Consistent with a role in the recognition or repair of intracellular damage, an orthologue of Ro in the radiation-resistant eubacterium Deinococcus radiodurans contributes to survival of this bacterium after UV irradiation. Here, we show that mice lacking the Ro protein develop an autoimmune syndrome characterized by anti-ribosome antibodies, anti-chromatin antibodies, and glomerulonephritis. Moreover, in one strain background, Ro-/- mice display increased sensitivity to irradiation with UV light. Thus, one function of this major human autoantigen may be to protect against autoantibody development, possibly by sequestering defective ribonucleoproteins from immune surveillance. Furthermore, the finding that mice lacking the Ro protein are photosensitive suggests that loss of Ro function could contribute to the photosensitivity associated with anti-Ro antibodies in humans.

  19. Water as a crucial driver in a community's development, elucidating human - water feedbacks in the Upper Ewaso Ngi'ro basin, Kenya

    Science.gov (United States)

    Kuil, Linda; McCord, Paul; Evans, Tom; Bloeschl, Guenter

    2017-04-01

    In Kenya, as in all of East/Southern Africa, agriculture is dominated by smallholder farmers. Small scale farming systems produce a significant amount of food contributing up to 70 % of the world's food need. Thus despite the increase in large-scale farming systems, smallholder farms have a continued role to play in feeding our growing world population. At the same time, farmers are subject to multiple stressors including resource uncertainty and pressure due to population growth threatening the livelihood of these communities. Informed by a rich empirical data set at household level collected in the Upper Ewaso Ngi'ro basin, Kenya in 2013, we take a socio-hydrological approach to improve our understanding of the interplay between water and society in regard to these smallholder systems. Stepwise, we identify the system's main drivers and the community's adaptive responses. We conceptualize the system using the state variables soil moisture (S), wealth (W), memory (M) and crop fraction (C). We find a gradual positive relation between water availability and the proportion of shallow rooted crops. Also, agricultural income is higher for those who cultivate shallow rooted crops, although here the transition is discontinuous. These findings suggest that although water is not a sufficient condition to obtain a better income, it currently seems a necessary feature. One of the goals of Kenyan IWRM water policy is to accomplish an equitable division water in times of scarcity to ensure the sustenance of all people including the most vulnerable. The chance to successfully achieve this goal will greatly increase when farmers that currently depend on the higher water availability to maintain their wealth are, at the same time, able to individually and collectively find ways to improve the efficiency of water use.

  20. Fellow's Apéro

    CERN Multimedia

    Staff Association

    2017-01-01

    Let's get together, meet each other, exchange experiences and ideas, and share useful information on CERN and the Staff Association. Join us for Fellow's Apéro, organised by the Staff Association on Tuesday 21 February at 16.30 in Restaurant 1. There will be drinks and snacks for everybody! We look forward to seeing you there! Please confirm your participation on Doodle http://doodle.com/poll/skvm7ucm2z78i6bt or alternatively on Facebook https://www.facebook.com/events/1862757017340069/. Your delegates in the Staff Association, Barbora & Jiri

  1. Capacity Analysis of Ro-Ro Terminals by Using Simulation Modeling Method

    Directory of Open Access Journals (Sweden)

    Emin Deniz Özkan

    2016-09-01

    Full Text Available In Ro-Ro terminals, terminal capacity is more needed than other types of marine terminals since Ro-Ro cargoes cannot be stacked. In this sense, the variables affecting capacity of a Ro-Ro terminal can be listed as follows; number of vehicles arrived to a terminal, distance between terminals, ship capacity, terminal gates, customs control units, terminal traffic and local traffic, security check, bunkering services etc. In this study, a model generated intended for making capacity analysis in Ro-Ro terminals by using simulation modeling method. Effect of three variables to terminal capacity was investigated while generating the scenarios; ‘number of trucks arriving to terminals’, ‘distance between terminals’ and ‘Ro-Ro ship capacity’. The results show that the variable which affect terminal capacity mostly is ‘number of trucks arriving to terminals’. As a consequence of this situation, it is thought that a Ro-Ro terminal operator must prioritize the demand factor and make an effective demand forecasting in determination of the terminal area.

  2. Tumor-infiltrating CD45RO(+) Memory T Lymphocytes Predict Favorable Clinical Outcome in Solid Tumors.

    Science.gov (United States)

    Hu, Guoming; Wang, Shimin

    2017-09-04

    The prognostic role of tumor-infiltrating CD45RO(+) memory T lymphocytes (CD45RO(+) T cells) in human solid tumors remains controversial. Herein, we conducted a meta-analysis including 25 published studies with 4720 patients identified from PubMed and EBSCO to assess the prognostic impact of tumor-infiltrating CD45RO(+) T cells in human solid tumors. We found that CD45RO(+) T cell infiltration was significantly associated with improved overall survival (OS) and disease-free survival (DFS) in all types of solid tumors. In stratified analyses, CD45RO(+) T cell infiltration significantly improved 1-year, 3-year and 5-year OS in colorectal, gastric and esophageal cancer, but only 5-year OS in hepatocellular carcinoma. And these cells were positively associated with 1-year, 3-year and 5-year DFS in hepatocellular, colorectal and esophageal cancer. In addition, high density of intratumoral CD45RO(+) T cells inversely correlated with TNM stage of solid tumor. In conclusion, CD45RO(+) memory T lymphocyte infiltration leads to a favorable clinical outcome in solid tumors, implicating that it is a valuable biomarker for prognostic prediction for human solid malignances.

  3. [Comparison of tests for SS-A/Ro, Ro52 and Ro60 in predicting congenital heart block].

    Science.gov (United States)

    Miyano, Akira; Nakayama, Masahiro; Waguri, Masako; Nakanishi, Isao

    2014-04-01

    Neonatal lupus erythematosus (NLE) is a rare syndrome caused by the transplacental passage of maternal autoantibodies. Anti SS-A antibodies of a mother with Sjögren syndrome are associated with congenital heart block (CHB) in the newborns with NLE. The purpose of this study was to investigate the utility of maternal antibody titers for SS-A, Ro52 and Ro60 in mothers of newborns with CHB. The study involved a total of 304 cases, 25 from mothers of newborns with CHB, 104 from mothers of newborns without and 175 from mothers suspected to have connective tissue diseases. All sera were tested with the EliA SS-A, EliA Ro52, EliA Ro60, MESACUP Ro52 and MESACUP Ro60. The concordance rate of Ro52 assays was 93.4%, whereas Ro60 assays showed a lower concordance rate (74.7%). The areas under the curve (AUC) of the EliA assays were higher than those of the MESACUP assays. The optimal cut-off values for EliA SS-A/Ro and EliA Ro60 as derived from the ROC analysis were 2027 U/mL and 2446 U/mL, respectively. The sensitivity and specificity for EliA SS-A using optimal cut-off values were 96.0% and 92.3%, respectively. A titer of 90% positive predictive value for EliA SS-A was reached at a cut-off of 9897.1 U/mL, corresponding to sensitivity and specificity values of 36.0% and 100%, respectively. In conclusion, the optimal cut-off value for EliA SS-A is likely to be useful for application in clinical practice for the EliA SS-A measurements in mothers to evaluate the risk of NLE for their newborns.

  4. Linc-RoR promotes c-Myc expression through hnRNP I and AUF1

    Science.gov (United States)

    Huang, Jianguo; Zhang, Ali; Ho, Tsui-Ting; Zhang, Ziqiang; Zhou, Nanjiang; Ding, Xianfeng; Zhang, Xu; Xu, Min; Mo, Yin-Yuan

    2016-01-01

    Linc-RoR was originally identified to be a regulator for induced pluripotent stem cells in humans and it has also been implicated in tumorigenesis. However, the underlying mechanism of Linc-RoR-mediated gene expression in cancer is poorly understood. The present study demonstrates that Linc-RoR plays an oncogenic role in part through regulation of c-Myc expression. Linc-RoR knockout (KO) suppresses cell proliferation and tumor growth. In particular, Linc-RoR KO causes a significant decrease in c-Myc whereas re-expression of Linc-RoR in the KO cells restores the level of c-Myc. Mechanistically, Linc-RoR interacts with heterogeneous nuclear ribonucleoprotein (hnRNP) I and AU-rich element RNA-binding protein 1 (AUF1), respectively, with an opposite consequence to their interaction with c-Myc mRNA. While Linc-RoR is required for hnRNP I to bind to c-Myc mRNA, interaction of Linc-RoR with AUF1 inhibits AUF1 to bind to c-Myc mRNA. As a result, Linc-RoR may contribute to the increased stability of c-Myc mRNA. Although hnRNP I and AUF1 can interact with many RNA species and regulate their functions, with involvement of Linc-RoR they would be able to selectively regulate mRNA stability of specific genes such as c-Myc. Together, these results support a role for Linc-RoR in c-Myc expression in part by specifically enhancing its mRNA stability, leading to cell proliferation and tumorigenesis. PMID:26656491

  5. Probabilistic Analysis of Collision Damages with Application to ro-Ro Passenger Vessels

    DEFF Research Database (Denmark)

    Pedersen, Preben Terndrup; Hansen, Peter Friis; Nielsen, Lars Peter

    1997-01-01

    for evaluation of the probability of a Ro-Ro passenger vessel on a given route being struck by another ship. Given a collision has taken place the spatial distribution of the collision damages is calculated. Results are presented in terms of probability distributions, for indentation depth, length and height...... of the holes and for the vertical location. The main benefit of the formulated procedure is that it allows comparisons of various navigation routes by assessing the relative frequencies of collisions. The derived procedure is applied to two typical Ro-Ro passenger vessel routes....

  6. Ro small cytoplasmic ribonucleoproteins are a subclass of La ribonucleoproteins: Further characterization of the Ro and La small ribonucleoproteins from uninfected mammalian cells

    Energy Technology Data Exchange (ETDEWEB)

    Hendrick, J.P.; Wolin, S.L.; Rinke, J.; Lerner, M.R.; Steitz, J.A.

    1981-12-01

    Small ribonucleic acid (RNA)-protein complexes precipitated by anti-Ro and anti-La antibodies from lupus patients have been examined with emphasis on their RNA components. In both ribonucleoprotein (RNP) classes, the numbers of different RNA molecules and their sequences vary between mouse and human cells. The complex mixtures of La RNAs include two previously sequenced 4.5S RNAs from mouse cells and 5S ribosomal RNA-like molecules from both mouse and human cells. All Ro and La RNAs possess 5'-triphosphates. Some La RNAs have internal modifications typical of transfer RNAs. The RoRNPs are quite stable and are localized by immunofluorescence in the cell cytoplasm, whereas the majority of the La RNPs turn over rapidly and reside in the nucleus. Despite these differences, reconstitution experiments show that the Ro particles carry the La as well as the Ro determinant. Studies using a nuclear transcription system demonstrate that most of the La RNAs are synthesized by RNA polymerase III. The possibility that the La protein(s) functions in the transcription or maturation of all RNA polymerase III transcripts is discussed.

  7. Elements of Risk Analysis for Collision and Grounding of a RoRo Passenger Ferry

    DEFF Research Database (Denmark)

    Otto, S.; Pedersen, Preben Terndrup; Samuelidis, M.

    2002-01-01

    Newly developed software was applied to study the effects of damages due to collision and grounding. The annual risk of collision and grounding was computed for an example RoRo passenger ferry. Collision frequency was evaluated for a specified route taking into account traffic data. Grounding...

  8. Chemoenzymatic synthesis of Ro 25-8210 and Ro 25-6630

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    Here we report the chemoenzymatic synthesis of Ro 25-8210 (1) and Ro 25-6630 (2) by using microbial reduction of a -chloromethyl ketone 4 mediated with baker's yeast and Geotrichum sp. to afford the optically active (R) and (S)-a -chlorohydrin 8 respectively as the key step.

  9. Cholesterol biosynthesis inhibitor RO 48-8071 suppresses growth of hormone-dependent and castration-resistant prostate cancer cells.

    Science.gov (United States)

    Liang, Yayun; Mafuvadze, Benford; Aebi, Johannes D; Hyder, Salman M

    2016-01-01

    Standard treatment for primary prostate cancer includes systemic exposure to chemotherapeutic drugs that target androgen receptor or antihormone therapy (chemical castration); however, drug-resistant cancer cells generally emerge during treatment, limiting the continued use of systemic chemotherapy. Patients are then treated with more toxic standard therapies. Therefore, there is an urgent need for novel and more effective treatments for prostate cancer. The cholesterol biosynthetic pathway is an attractive therapeutic target for treating endocrine-dependent cancers because cholesterol is an essential structural and functional component of cell membranes as well as the metabolic precursor of endogenous steroid hormones. In this study, we have examined the effects of RO 48-8071 (4'-[6-(allylmethylamino)hexyloxy]-4-bromo-2'-fluorobenzophenone fumarate; Roche Pharmaceuticals internal reference: RO0488071) (RO), which is an inhibitor of 2, 3-oxidosqualene cyclase (a key enzyme in the cholesterol biosynthetic pathway), on prostate cancer cells. Exposure of both hormone-dependent and castration-resistant human prostate cancer cells to RO reduced prostate cancer cell viability and induced apoptosis in vitro. RO treatment reduced androgen receptor protein expression in hormone-dependent prostate cancer cells and increased estrogen receptor β (ERβ) protein expression in both hormone-dependent and castration-resistant prostate cancer cell lines. Combining RO with an ERβ agonist increased its ability to reduce castration-resistant prostate cancer cell viability. In addition, RO effectively suppressed the growth of aggressive castration-resistant human prostate cancer cell xenografts in vivo without any signs of toxicity to experimental animals. Importantly, RO did not reduce the viability of normal prostate cells in vitro. Our study is the first to demonstrate that the cholesterol biosynthesis inhibitor RO effectively suppresses growth of human prostate cancer cells. Our

  10. Premier numéro bilingue

    Directory of Open Access Journals (Sweden)

    Esther Cloutier

    2008-05-01

    Full Text Available Nous sommes heureux de vous présenter ce nouveau numéro bilingue de la revue PISTES. Nous espérons ainsi faire connaître les travaux francophones sur la santé au travail dans le monde anglo-saxon. Nous vous rappelons que la traduction de ce numéro a été rendu possible grâce à une subvention du CRSH (Conseil de la recherche en sciences humaines du Canada ainsi qu’à la contribution de certains auteurs que nous tenons à remercier. Ce numéro aborde plusieurs thèmes de recherche reliés au travail...

  11. Small RoPax Vessel stability study

    DEFF Research Database (Denmark)

    Erichsen, Henrik; Kristensen, Hans Otto Holmegaard; Jensen, Jørgen Juncher;

    2015-01-01

    In 2009 new damage stability requirements for passenger ships based on a probabilistic method were adopted by IMO and are now part of the current SOLAS Chapter II-1 regulations (SOLAS 2009). The mandate from IMO was to keep the same safety level as inherent in the old deterministic damage stability......-representative”. Currently there is a renewed debate in IMO regarding the required damage stability safety level for passenger ships. The damage stability safety level for small ro/pax vessels has also been discussed outside of the IMO assuming that the damage stability safety level for small ro/pax designs is perhaps...... not sufficient, i.e. that the current safety level according to SOLAS 2009 is less than the old safety level according to SOLAS 90. In order to establish a solid foundation for the discussion, this study was made possible by a grant from The Danish Maritime Fund. The study focus on small ro/pax vessels...

  12. CoRoT pictures transiting exoplanets

    CERN Document Server

    Moutou, Claire

    2015-01-01

    The detection and characterization of exoplanets have made huge progresses since the first discoveries in the late nineties. In particular, the independent measurement of the mass and radius of planets, by combining the transit and radial-velociy techniques, allowed exploring their density and hence, their internal structure. With CoRoT (2007-2012), the pioneering CNES space-based mission in this investigation, about thirty new planets were characterized. CoRoT has enhanced the diversity of giant exoplanets and discovered the first telluric exoplanet. Following CoRoT, the NASA Kepler mission has extended our knowledge to small-size planets, multiple systems and planets orbiting binaries. Exploring these new worlds will continue with the NASA/TESS (2017) and ESA/PLATO (2024) missions.

  13. RoCoS紧密纺纱新技术%RoCoS compact spinning technology

    Institute of Scientific and Technical Information of China (English)

    刘林兵; 高卫东; 程丙伟

    2005-01-01

    文章介绍了一种新的紧密纺纱技术--RoCoS(Rotorcraft Compact Spinning System).RoCoS紧密纺纱系统借助于RoCoS组合件构成三罗拉四皮辊牵伸结构,采用磁铁--机械式原理集束,相继实现纱线的牵伸、集聚和加捻.RoCoS紧密纺纱技术结构简单,安装便捷,使用可靠,维护方便,克服了传统气流集束式紧密纺技术的不足.它适于纺棉型或毛型纱线,可用于新机或老机改造,是一种有较强市场发展潜力的新型紧密纺纱技术.

  14. Fault-tree Models of Accident Scenarios of RoPax Vessels

    Institute of Scientific and Technical Information of China (English)

    Pedro Ant(a)o; C. Guedes Soares

    2006-01-01

    Ro-Ro vessels for cargo and passengers (RoPax) are a relatively new concept that has proven to be popular in the Mediterranean region and is becoming more widespread in Northern Europe. Due to its design characteristics and amount of passengers, although less than a regular passenger liner, accidents with RoPax vessels have far reaching consequences both for economical and for human life. The objective of this paper is to identify hazards related to casualties of RoPax vessels. The terminal casualty events chosen are related to accident and incident statistics for this type of vessel. This paper focuses on the identification of the basic events that can lead to an accident and the performance requirements. The hazard identification is carried out as the first step of a Formal Safety Assessment (FSA) and the modelling of the relation between the relevant events is made using Fault Tree Analysis (FTA). The conclusions of this study are recommendations to the later steps of FSA rather than for decision making (Step 5 of FSA). These recommendations will be focused on the possible design shortcomings identified during the analysis by fault trees throughout cut sets. Also the role that human factors have is analysed through a sensitivity analysis where it is shown that their influence is higher for groundings and collisions where an increase of the initial probability leads to the change of almost 90% of the accident occurrence.

  15. SYNCHRONOUS EFFECT OF SLIPPING HEAVY LOADS ON RO-RO SHIP ROLLING IN WAVES

    Institute of Scientific and Technical Information of China (English)

    ZHANG Yin-long; SHEN Qing; CHEN Xu-jun

    2006-01-01

    Common effect of wave and slip of internal vehicles will make rolling of the roll-on ship serious. This is one of the important reasons for overturn of ro-ro ships. The multibody system with a floating base is composed of ro-ro ship and slipping vehicles.Takes the rolling angle of the ship and the transverse displacements of the slipping vehicles on desk as freedoms. Making use of the analysis of apparent gravitation and apparent buoyancy, the wave rolling moment is derived. By means of dynamic method of multibody system, dynamic equations of the system are established. Taking a certain channel ferry as an example, a set of numerical calculation have been carried out for rolling response of the multibody system with a floating base of a ro-ro ship and displacements response of the slipping vehicles under common effect of free slipping vehicles and wave, and a conclusion has been drawn that the motion of the numerous free slipping heavy loads will trend to be synchronous under restraining of the side-wall bulkhead with time because of repeated collision.

  16. RO-heparin Inhibits L-Selectin-mediated Neutrophils Adhesion to Vascular Endothelium Under Flow Conditions

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Selectins are carbohydrate-binding cell adhesion molecules that play a major role in the initiation of inflammatory responses. Accumulaed evidence has suggested that heparin's anti-inflammatory effects are mainly mediated by blocking L- or P-selectin-initiated cell adhesion. Recently, we have reported that periodate-oxidized, borohydridereduced heparin (RO-heparin) can inhibit P-selectin-mediated acute inflammation. Here we further examined the effect of RO-heparin on the adhesion of L-selectin-mediated leukocytes to vascular endothelium under flow conditions in vivo and in vitro. The results show that RO-heparin with a low anticoagulant activity can effectively reduce leucocyte rolling on thioglycollate-induced rat mesenteric venules and L-selectin-metadiated neutrophil rolling on TNF-α-induced human umbilical vein endothelial cells(HUVECs) under flow conditions. Our findings suggest that the effect of RO-heparin on inflammatory responses is mainly a result of its inhibiting the interaction between P- or L-selectin and its ligands. The findings also suggest that RO-heparin may be useful in preventing inflammation diseases.

  17. Secondary eclipses in the CoRoT light curves

    Directory of Open Access Journals (Sweden)

    Belmonte Juan Antonio

    2013-04-01

    Full Text Available We identify and characterize secondary eclipses in the original light curves of published CoRoT planets using uniform detection and evaluation criteria. Our analysis is based on a Bayesian statistics: the eclipse search is carried out using Bayesian model selection, and the characterization of the plausible eclipse candidates using Bayesian parameter estimation. We discover statistically significant eclipse events for two planets, CoRoT-6b and CoRoT-11b, and for one brown dwarf, CoRoT-15b. We also find marginally significant eclipse events passing our plausibility criteria for CoRoT-3b, 13b, 18b, and 21b, and confirm the previously published CoRoT-1b and CoRoT-2b eclipses.

  18. Introduction au numéro

    Directory of Open Access Journals (Sweden)

    Diane-Gabrielle Tremblay

    2002-01-01

    Full Text Available Ce numéro de la revue Interventions économiques a pour thème la métropolisation. La revue avait invité Jean-Marc Fontan à agir à titre d’éditeur invité pour ce numéro. Il a donc organisé un séminaire en vue de produire ensuite un numéro sur ce thème. Aussi, l’article rédigé par Jean-Marc Fontan présente-t-il la problématique que nous avons voulu développer en lançant le débat et les échanges sur le thème de la métropolisation et du rôle des métropoles dans le développement régional et le déve...

  19. AstRoMap European Astrobiology Roadmap.

    Science.gov (United States)

    Horneck, Gerda; Walter, Nicolas; Westall, Frances; Grenfell, John Lee; Martin, William F; Gomez, Felipe; Leuko, Stefan; Lee, Natuschka; Onofri, Silvano; Tsiganis, Kleomenis; Saladino, Raffaele; Pilat-Lohinger, Elke; Palomba, Ernesto; Harrison, Jesse; Rull, Fernando; Muller, Christian; Strazzulla, Giovanni; Brucato, John R; Rettberg, Petra; Capria, Maria Teresa

    2016-03-01

    The European AstRoMap project (supported by the European Commission Seventh Framework Programme) surveyed the state of the art of astrobiology in Europe and beyond and produced the first European roadmap for astrobiology research. In the context of this roadmap, astrobiology is understood as the study of the origin, evolution, and distribution of life in the context of cosmic evolution; this includes habitability in the Solar System and beyond. The AstRoMap Roadmap identifies five research topics, specifies several key scientific objectives for each topic, and suggests ways to achieve all the objectives. The five AstRoMap Research Topics are • Research Topic 1: Origin and Evolution of Planetary Systems • Research Topic 2: Origins of Organic Compounds in Space • Research Topic 3: Rock-Water-Carbon Interactions, Organic Synthesis on Earth, and Steps to Life • Research Topic 4: Life and Habitability • Research Topic 5: Biosignatures as Facilitating Life Detection It is strongly recommended that steps be taken towards the definition and implementation of a European Astrobiology Platform (or Institute) to streamline and optimize the scientific return by using a coordinated infrastructure and funding system.

  20. Expression of the Memory Marker CD45RO on Helper T Cells in Macaques

    NARCIS (Netherlands)

    Valentine, Michael; Song, Kejing; Maresh, Grace A.; Mack, Heather; Huaman, Maria Cecilia; Polacino, Patricia; Ho, On; Cristillo, Anthony; Chung, Hye Kyung; Hu, Shiu-Lok; Pincus, Seth H.

    2013-01-01

    Background: In humans it has been reported that a major site of the latent reservoir of HIV is within CD4+ T cells expressing the memory marker CD45RO, defined by the mAb UCHL1. There are conflicting reports regarding the expression of this antigen in macaques, the most relevant animal species for s

  1. The CoRoT Exoplanet program: status & results

    Directory of Open Access Journals (Sweden)

    Moutou C.

    2011-02-01

    Full Text Available The CoRoT satellite is the first instrument hunting for planets from space. We will review the status of the CoRoT/Exoplanet program. We will then present the CoRoT exoplanetary systems and how they widen the range of properties of the close-in population and contribute to our understanding of the properties of planets.

  2. Coherent Ro-vibrational Revivals in a Thermal Molecular Ensemble

    CERN Document Server

    Bitter, Martin; Milner, Valery

    2012-01-01

    We report an experimental and theoretical study of the evolution of vibrational coherence in a thermal ensemble of nitrogen molecules. Rotational dephasing and rephasing of the vibrational coherence is detected by coherent anti-Stokes Raman scattering. The existence of ro-vibrational coupling and the discrete energy spectrum of the rotational bath lead to a whole new class of full and fractional ro-vibrational revivals. Following the rich ro-vibrational dynamics on a nanosecond time scale with sub-picosecond time resolution enables us to determine the second-order ro-vibrational constant $gamma_e$ and assess new possibilities of controlling decoherence.

  3. Expression of the memory marker CD45RO on helper T cells in macaques.

    Directory of Open Access Journals (Sweden)

    Michael Valentine

    Full Text Available BACKGROUND: In humans it has been reported that a major site of the latent reservoir of HIV is within CD4+ T cells expressing the memory marker CD45RO, defined by the mAb UCHL1. There are conflicting reports regarding the expression of this antigen in macaques, the most relevant animal species for studying HIV pathogenesis and testing new therapies. There is now a major effort to eradicate HIV reservoirs and cure the infection. One approach is to eliminate subsets of cells housing the latent reservoir, using UCHL1 to target these cells. So that such studies may be performed in macaques, it is essential to determine expression of CD45RO. METHODS: We have used immunofluorescence and flow cytometry to study cell surface expression of CD45RO on lymphocytes from PBMC, lymphoid, and GI organs of rhesus, pigtailed, and cynomolgus macaques. Both direct and indirect immunofluorescence experiments were performed. FINDINGS: CD45RO is expressed on a subset of CD4+ lymphocytes of all pigtailed, a fraction of rhesus, and neither of the cynomolgus macaques studied. The binding of UCHL1 to macaque cells was of lower avidity than to human cells. This could be overcome by forming UCHL1 multimers. Directly conjugating fluors to UCHL1 can inhibit UCHL1 binding to macaque cells. Patterns of UCHL1 expression differ somewhat in macaques and humans, and from that of other memory markers often used in macaques. CONCLUSIONS: CD45RO, defined with mAb UCHL1, is well expressed on CD4+ cells in pigtailed macaques. Using tissues recovered from latently infected pigtailed macaques we are determining whether UCHL1, or other memory markers, can define the cellular locus of the reservoir. The low avidity of this interaction could limit the utility of UCHL1, in its conventional form, to eliminate cells in vivo and test this approach in macaque models of HIV infection.

  4. Model experiment on capsizing of damaged RO-RO passenger ship in beam seas; Sonsho shita RO-RO kyakusen no ohachu tenpuku ni kansuru mokei jikken

    Energy Technology Data Exchange (ETDEWEB)

    Haraguchi, T.; Ishida, S. [Ministry of Transportation, Tokyo (Japan)] Murashige, S. [Tokyo Univ. (Japan)

    1998-12-31

    In this study, a model of the RO-RO passenger ship was made, a capsizing experiment was carried out in a case of a damaged crack existed in higher wave height side in the beam seas. The main results were obtained as follows: the restored standard after damage was satisfied in the Treaty of Safety of Life at Sea (SOLAS`90) and the capsizing would not happen in the case of no initial heel. In the case with initial heel, ship would be heeled to the side of higher wave height with damage crack, capsizing would happen when the significant wave height was higher and the permeability to the car deck was larger. That is, it was necessary for residence water to easily stay in the damage side with the initial heel in order that the capsizing happened. In the case of the capsizing with an initial heel, the critical height of the residence water on the car deck was nearly in agreement with the British proposal: `calculation equations showing necessary restored performance in consideration of the permeation to the car deck`, when the peak period in wave spectrum was 7 to 9 seconds. There is no agreement when the peak period is longer than that. 11 refs., 15 figs., 4 tabs.

  5. Cholesterol biosynthesis inhibitor RO 48-8071 suppresses growth of hormone-dependent and castration-resistant prostate cancer cells

    Directory of Open Access Journals (Sweden)

    Liang Y

    2016-05-01

    Full Text Available Yayun Liang,1 Benford Mafuvadze,1 Johannes D Aebi,2 Salman M Hyder1 1Dalton Cardiovascular Research Center and Department of Biomedical Sciences, University of Missouri-Columbia, Columbia, MO, USA; 2Medicinal Chemistry, Roche Pharma Research and Early Development (pRED, Roche Innovation Center Basel, F Hoffmann-La Roche Ltd., Basel, Switzerland Abstract: Standard treatment for primary prostate cancer includes systemic exposure to chemotherapeutic drugs that target androgen receptor or antihormone therapy (chemical castration; however, drug-resistant cancer cells generally emerge during treatment, limiting the continued use of systemic chemotherapy. Patients are then treated with more toxic standard therapies. Therefore, there is an urgent need for novel and more effective treatments for prostate cancer. The cholesterol biosynthetic pathway is an attractive therapeutic target for treating endocrine-dependent cancers because cholesterol is an essential structural and functional component of cell membranes as well as the metabolic precursor of endogenous steroid hormones. In this study, we have examined the effects of RO 48-8071 (4'-[6-(allylmethylaminohexyloxy]-4-bromo-2'-fluorobenzophenone fumarate; Roche Pharmaceuticals internal reference: RO0488071 (RO, which is an inhibitor of 2, 3-oxidosqualene cyclase (a key enzyme in the cholesterol biosynthetic pathway, on prostate cancer cells. Exposure of both hormone-dependent and castration-resistant human prostate cancer cells to RO reduced prostate cancer cell viability and induced apoptosis in vitro. RO treatment reduced androgen receptor protein expression in hormone-dependent prostate cancer cells and increased estrogen receptor β (ERβ protein expression in both hormone-dependent and castration-resistant prostate cancer cell lines. Combining RO with an ERβ agonist increased its ability to reduce castration-resistant prostate cancer cell viability. In addition, RO effectively suppressed the

  6. Le royaume de Méroé

    Directory of Open Access Journals (Sweden)

    Claude Rilly

    2010-04-01

    Full Text Available La civilisation napato-méroïtique qui domine le cours du Nil moyen, d’Assouan à Khartoum, depuis le viiie siècle av. J.-C. jusqu’au ive siècle apr. J.-C., fait suite à la colonisation égyptienne du Soudan ancien. Par sa religion, son idéologie, ses institutions, sa culture matérielle, elle se rattache étroitement au modèle égyptien à tel point que l’on peut parler d’une « civilisation pharaonique » dont l’Égypte et le Soudan ancien seraient les deux versants. L’histoire du royaume de Méroé est assez mal connue dans le détail, d’une part parce que les textes méroïtiques sont peu nombreux et très partiellement compris, d’autre part en raison d’une couverture archéologique relativement récente et clairsemée. Les sources extérieures, égyptiennes, grecques et romaines, sont assez laconiques et moyennement fiables. Les progrès récents de l’archéologie et de la philologie du Soudan ancien laissent toutefois espérer de prochaines avancées.The Napatan-Meroitic civilisation flourished in the Middle Nile valley from the 8th century BC to the 4th century AD. It inherited from the former Egyptian colonisation cultural patterns that are obvious in religious and ideological fields as much as in institutions or artefacts. One could even speak of a “Pharaonic civilization” with two sides, Egypt and Ancient Sudan. Little is known from the history of the kingdom of Meroe, first because Meroitic texts are in small number and poorly understood and secondly because archaeological excavations are fairly recent and scattered. External sources such as Egyptian, Greek and Roman evidences are scanty and moderately reliable. However recent progress in the archaeology and philology of Ancient Sudan is currently improving the knowledge of this civilisation.

  7. The CoRoT mission's exoplanet program

    Directory of Open Access Journals (Sweden)

    Deeg H.J.

    2013-04-01

    Full Text Available The CoRoT space observatory was launched at the end of 2006 and has been delivering scientific data from early 2007 until its recent interruption, on 2 Nov. 2012, leading to the discovery of over 30 transiting planets. Here we give an overview over the most relevant results from CoRoT's exoplanet detection program.

  8. SyRoTek--Distance Teaching of Mobile Robotics

    Science.gov (United States)

    Kulich, M.; Chudoba, J.; Kosnar, K.; Krajnik, T.; Faigl, J.; Preucil, L.

    2013-01-01

    E-learning is a modern and effective approach for training in various areas and at different levels of education. This paper gives an overview of SyRoTek, an e-learning platform for mobile robotics, artificial intelligence, control engineering, and related domains. SyRoTek provides remote access to a set of fully autonomous mobile robots placed in…

  9. Introduction au numéro

    Directory of Open Access Journals (Sweden)

    Diane-Gabrielle Tremblay

    2005-07-01

    Full Text Available Depuis quelques années, le thème de l’économie sociale fait couler beaucoup d’encre au Québec, comme ailleurs. Ce numéro présente un bilan de l’économie sociale au Québec, coordonné par Jean-Marc Fontan et Denis Bussières. Toutefois, afin d’avoir un portrait plus global et une perspective théorique sur la question, Interventions économiques a sollicité un texte de Jacques Defourny, afin de compléter le dossier. En effet, l’économie sociale, les secteurs non-marchands, les services de proximi...

  10. Pro-inflammatory role of Anti-Ro/SSA autoantibodies through the activation of Furin-TACE-amphiregulin axis.

    Science.gov (United States)

    Lisi, Sabrina; Sisto, Margherita; Lofrumento, Dario Domenico; Cucci, Liana; Frassanito, Maria Antonia; Mitolo, Vincenzo; D'Amore, Massimo

    2010-09-01

    Prolonged inflammation can be detrimental because it may cause host toxicity and tissue damage. Indeed, excessive production of inflammatory cytokines is often associated with many autoimmune diseases. In this study we demonstrate that the anti-Ro/SSA autoantibodies (Abs) stimulate the production of pro-inflammatory cytokines IL-6 and IL-8 by human healthy salivary gland epithelial cells (healthy SGEC). The secretion of these cytokines is due to amphiregulin (AREG) that is overexpressed in healthy SGEC treated with anti-Ro/SSA Abs and in Sjögren's syndrome. We have discovered that the up-regulation of AREG occurs through TNF-alpha produced following anti-Ro/SSA Abs treatment. The gene silencing technique was used to study the AREG-TNF-alpha-IL-6/IL-8 secretion pathway, demonstrating that: (i) TNF-alpha gene silencing provokes a significant decrease of proinflammatory cytokines production and AREG expression in anti-Ro/SSA Abs-treated healthy SGEC; (ii) AREG gene silencing has a potent inhibitory effect on TNF-alpha-induced IL-6 and IL-8 secretion in healthy SGEC treated with anti-Ro/SSA Abs. These findings indicate that TACE-mediated AREG shedding plays a critical role in TNF-alpha-induced IL-6 and IL-8 secretion by the human healthy salivary gland epithelial cells, suggesting that this may be one of the possible intracellular mechanisms involved in the salivary glands inflammatory response in Sjögren's syndrome.

  11. A Phase II Study of RO4929097 Gamma-Secretase Inhibitor in Metastatic Melanoma: SWOG 0933

    Science.gov (United States)

    Lee, Sylvia M.; Moon, James; Redman, Bruce G.; Chidiac, Tarek; Flaherty, Lawrence E.; Zha, Yuanyuan; Othus, Megan; Ribas, Antoni; Sondak, Vernon K.

    2014-01-01

    Background Aberrant Notch activation confers a proliferative advantage onto many human tumors, including melanoma. This phase II trial assessed the antitumor activity of RO4929097, a gamma-secretase inhibitor of Notch signaling, on the progression-free and overall survival of patients with advanced melanoma. Methods Chemotherapy-naïve patients with metastatic melanoma of cutaneous or unknown origin were treated with RO4929097 at a dose of 20 mg orally daily, 3 consecutive days per week. A two-step accrual design was used, with an interim analysis on the first 32 patients, and continuation of enrollment if ≥4/32 patients responded. Results Thirty-six patients from 23 institutions were enrolled; 32 patients were evaluable. RO4929097 was well-tolerated, and most toxicities were grade 1 or 2. The most common toxicities were nausea (53%), fatigue (41%), and anemia (22%). There was 1 confirmed partial response lasting 7 months, and 8 patients with stable disease lasting at least through week 12, with one of these continuing for 31 months. The 6-month PFS was 9% (95% CI: 2–22%), and 1-year OS was 50% (95% CI: 32–66%). Peripheral blood T cell assays showed no significant inhibition of IL-2 production, a surrogate pharmacodynamic marker of Notch inhibition, suggesting that the drug levels were insufficient to achieve Notch target inhibition. Conclusions RO4929097 showed minimal clinical activity against metastatic melanoma in this phase II trial, possibly due to inadequate exposure to therapeutic drug levels. While Notch inhibition remains a compelling target in melanoma, our results do not support further investigation of RO4929097 at this dose and schedule. PMID:25250858

  12. Correction to Clark and Ro (2014).

    Science.gov (United States)

    2015-01-01

    Reports an error in "Three-pronged assessment and diagnosis of personality disorder and its consequences: Personality functioning, pathological traits, and psychosocial disability" by Lee Anna Clark and Eunyoe Ro (Personality Disorders: Theory, Research, and Treatment, 2014[Jan], Vol 5[1], 55-69). There was an error in the results. Under the subheading, Personality Traits-Functioning Relations, on page 63, the second, third, and fourth paragraph have been revised. The revisions are included in the erratum. (The following abstract of the original article appeared in record 2014-07188-003.) The alternative dimensional model of personality disorder (PD) in the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5; American Psychiatric Association, 2013), Section III, has two main criteria: impairment in personality functioning and one or more pathological personality traits. The former is defined as disturbances in self-functioning (viz., identity, self-direction), and/or interpersonal functioning (viz., empathy, intimacy). Distinguishing personality functioning and traits is important conceptually, because simply having extreme traits is not necessarily pathological. However, adding personality functioning to PD diagnosis represents an empirical challenge, because the constructs overlap conceptually. Further, there is debate regarding whether diagnosis of mental disorder requires either distress or disability, concepts that also overlap with maladaptive-range personality traits and personality dysfunction. We investigated interrelations among these constructs using multiple self-report measures of each domain in a mixed community-patient sample (N = 402). We examined the structures of functioning (psychosocial disability and personality) and personality traits, first independently, then jointly. The disability/functioning measures yielded the 3 dimensions we have found previously (Ro & Clark, 2013). Trait measures had a hierarchical structure

  13. Receptor binding characterization of the benzodiazepine radioligand sup 125 I-Ro16-0154: Potential probe for SPECT (Single Photon Emission Computed Tomography) brain imaging

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, E.W.; Woods, S.W.; Zoghbi, S.; Baldwin, R.M.; Innis, R.B. (Yale Univ., West Haven, CT (USA)); McBride, B.J. (Medi-Physics, Inc., Emeryville, CA (USA))

    1990-01-01

    The binding of an iodinated benzodiazepine (BZ) radioligand has been characterized, particularly in regard to its potential use as a neuroreceptor brain imaging agent with SPECT (Single Photon Emission Computed Tomography). Ro16-0154 is an iodine-containing BZ antagonist and a close analog of Ro15-1788. In tissue homogenates prepared from human and monkey brain, the binding of {sup 125}I-labeled Ro16-0154 was saturable, of high affinity, and had high ratios of specific to non-specific binding. Physiological concentrations of NaCl enhanced specific binding approximately 15% compared to buffer without this salt. Kinetic studies of association and dissociation demonstrated a temperature dependent decrease in affinity with increasing temperature. Drug displacement studies confirmed that {sup 125}I-Ro16-0154 binds to the central type BZ receptor: binding is virtually identical to that of {sup 3}H-Ro15-1788 except that {sup 125}I-Ro16-0154 shows an almost 10 fold higher affinity at 37{degree}C. These in vitro results suggest that {sup 123}I-labeled Ro16-0154 shows promise as a selective, high affinity SPECT probe of the brain's BZ receptor.

  14. POF在RoF系统中的应用%Application of POF in RoF System

    Institute of Scientific and Technical Information of China (English)

    齐攀; 陈舜儿; 刘伟平; 黄红斌

    2007-01-01

    近年来塑料光纤(POF)作为短距离高速通信中石英光纤的替代品越来越受到人们的关注,尤其是RoF技术的成熟和发展给塑料光纤带来了很大的市场发展空间.本文介绍塑料光纤的发展及RoF系统,主要分析塑料光纤在RoF系统中的应用发展.

  15. 77 FR 1707 - National Toxicology Program (NTP) Final Process for Preparation of the Report on Carcinogens (RoC)

    Science.gov (United States)

    2012-01-11

    ... HUMAN SERVICES National Institutes of Health National Toxicology Program (NTP) Final Process for Preparation of the Report on Carcinogens (RoC) AGENCY: Division of the National Toxicology Program (DNTP...: December 21, 2011. John R. Bucher, Associate Director, National Toxicology Program. BILLING CODE 4140-01-P...

  16. Thematic trip: "Save Roşia MontanÄă"

    Science.gov (United States)

    Eugenia, Marcu

    2015-04-01

    The name Roşia Montană, situated in Transylvania, became well known after a Romanian-Canadian company, Roşia Montană Gold Company (RMGC), obtained the concession license on exploitation for gold and silver minerals in the Roşia Montană area. The project consists of opening the largest surface gold mines in Europe using cyanide, which will include four open pits and a processing plant for gold and silver in The Roşia Valley and a tailings facility with an area of 367 hectares in the Corna Valley. One of the main fears is related to a possible ecological accident like the one in Baia Mare in 2000, when a tailing facility dam break led to cyanide pollution of Tisa and Danube rivers that resulted in the death of 1,200 tons of fish and contamination of water resources for 2 million people. This thematic trip is important for the scientific preparation of students and an opportunity to educate them in the spirit of environmental protection. The training and education of students will require assimilation and understanding, actively and consciously, using the knowledge acquired during the compulsory curriculum and training skills. REASON: The continuous degradation of the environment is a major crisis due to human intervention in nature, and the proposed Roşia Montană mining project will continue this trend. The company proposes to extract gold from mines by using the gold separation technique using cyanide, a process that involves destroying a total area of 16 km² which includes 5 mountains, 7 churches, 11 cemeteries and the ruins of Alburnus Maior Citadel, as well as creating pollution that would last for hundreds of years. The extraction of gold from low-grade ores using cyanide processes was estimated to result in a worldwide emission of 45,300 tons of hydrogen cyanide. Environmental education for a healthy life has children as target group, because they are the trustees and beneficiaries of tomorrow's natural resources and can influence the attitudes of

  17. Tollivaba eksport ÜRO taga kinni / Andres Reimer

    Index Scriptorium Estoniae

    Reimer, Andres

    2002-01-01

    Ilmunud ka: Delovõje Vedomosti 20. veebr. lk. 7.ÜRO venitab juba pool aastat Eesti vastuvõtmisega Firenze kokkuleppe liikmeks, mille abil saaksid trükikojad alustada tollivaba kauplemist Venemaaga

  18. Tollivaba eksport ÜRO taga kinni / Andres Reimer

    Index Scriptorium Estoniae

    Reimer, Andres

    2002-01-01

    Ilmunud ka: Delovõje Vedomosti 20. veebr. lk. 7.ÜRO venitab juba pool aastat Eesti vastuvõtmisega Firenze kokkuleppe liikmeks, mille abil saaksid trükikojad alustada tollivaba kauplemist Venemaaga

  19. Derivation of the parameters of CoRoT planets

    Directory of Open Access Journals (Sweden)

    Dreyer C.

    2013-04-01

    Full Text Available We explore the influence that limb darkening and stellar activity have in the determination of planetary parameters, highlighting the impact that they have in space-based surveys, such as CoRoT.

  20. Protein Kinase C-Independent Inhibition of Organic Cation Transporter 1 Activity by the Bisindolylmaleimide Ro 31-8220.

    Directory of Open Access Journals (Sweden)

    Abdullah Mayati

    Full Text Available Ro 31-8220 is a potent protein kinase C (PKC inhibitor belonging to the chemical class of bisindolylmaleimides (BIMs. Various PKC-independent effects of Ro 31-8220 have however been demonstrated, including inhibition of the ATP-binding cassette drug transporter breast cancer resistance protein. In the present study, we reported that the BIM also blocks activity of the solute carrier organic cation transporter (OCT 1, involved in uptake of marketed drugs in the liver, in a PKC-independent manner. Ro 31-8220, in contrast to other pan-PKC inhibitors such as staurosporine and chelerythrine, was thus shown to cis-inhibit uptake of the reference OCT1 substrate tetraethylammonium in OCT1-transfected HEK293 cells in a concentration-dependent manner (IC50 = 0.18 μM and without altering membrane expression of OCT1. This blockage of OCT1 was also observed in human hepatic HepaRG cells that constitutionally express OCT1. It likely occurred through a mixed mechanism of inhibition. Ro 31-8220 additionally trans-inhibited TEA uptake in OCT1-transfected HEK293 cells, which likely discards a transport of Ro 31-8220 by OCT1. Besides Ro 31-8220, 7 additional BIMs, including the PKC inhibitor LY 333531, inhibited OCT1 activity, whereas 4 other BIMs were without effect. In silico analysis of structure-activity relationships next revealed that various molecular descriptors, especially 3D-WHIM descriptors related to total size, correspond to key physico-chemical parameters for inhibition of OCT1 activity by BIMs. In addition to activity of OCT1, Ro 31-8220 inhibited those of other organic cation transporters such as multidrug and toxin extrusion protein (MATE 1 and MATE2-K, whereas, by contrast, it stimulated that of OCT2. Taken together, these data extend the nature of cellular off-targets of the BIM Ro 31-8220 to OCT1 and other organic cation transporters, which has likely to be kept in mind when using Ro 31-8220 and other BIMs as PKC inhibitors in experimental or

  1. CoRoT’s first seven planets: An overview*

    Directory of Open Access Journals (Sweden)

    Barge P.

    2011-07-01

    Full Text Available The up to 150 day uninterrupted high-precision photometry of about 100000 stars – provided so far by the exoplanet channel of the CoRoT space telescope – gave a new perspective on the planet population of our galactic neighbourhood. The seven planets with very accurate parameters widen the range of known planet properties in almost any respect. Giant planets have been detected at low metallicity, rapidly rotating and active, spotted stars. CoRoT-3 populated the brown dwarf desert and closed the gap of measured physical properties between standard giant planets and very low mass stars. CoRoT extended the known range of planet masses down-to 5 Earth masses and up to 21 Jupiter masses, the radii to less than 2 Earth radii and up to the most inflated hot Jupiter found so far, and the periods of planets discovered by transits to 9 days. Two CoRoT planets have host stars with the lowest content of heavy elements known to show a transit hinting towards a different planet-host-star-metallicity relation then the one found by radial-velocity search programs. Finally the properties of the CoRoT-7b prove that terrestrial planets with a density close to Earth exist outside the Solar System. The detection of the secondary transit of CoRoT-1 at the 10−5-level and the very clear detection of the 1.7 Earth radii of CoRoT-7b at 3.5 10−4 relative flux are promising evidence of CoRoT being able to detect even smaller, Earth sized planets.

  2. The Dushak–Erekdag Survey of roAp Stars

    Indian Academy of Sciences (India)

    Tatyana Dorokhova; Nikolay Dorokhov

    2005-06-01

    The search of roAp stars at Mt. Dushak–Erekdag Observatory was started in 1992 using the 0.8m Odessa telescope equipped with a two-star high-speed photometer. We have observed more than a dozen stars so far and discovered HD 99563 as roAp star while BD+8087 is suspected to have rapid oscillations. Negative results of our observations for the search of rapid oscillations in four stars in NGC 752 are also discussed.

  3. Anti-ENA profiles related with anti-SS-A/Ro. The detection of Ro52 and Ro60 according to the presence of SS-B/La, and ANA pattern and titer.

    Science.gov (United States)

    González, D Almeida; Rodríguez, C Casañas; Armas, L Magdalena; Varela, A Roces; Rodríguez, I Marcelino; Duarte, M Troche; de León, A Cabrera

    2014-09-01

    Anti-Ro52 (Ro52) and anti-Ro60 (Ro60) antibodies are associated with different clinical entities. We investigated their relationship with the presence of anti-SS-B/La (SSB) antibody, the pattern and titer of antinuclear antibody (ANA), and the variations in antibody profiles related with anti-SS-A/Ro (SSA) positivity. Our aim was to develop a strategy to increase the efficiency of anti-extractable nuclear antigen (ENA) determinations. Statistical analyses were based on the Chi-squared test for categorical variables, the Mann-Whitney U test to compare profiles, and the odds ratio (OR) and 95% confidence interval (95% CI) to estimate the risk of variability. We analyzed 800 SSA-positive samples with Ro52 or Ro60 reactivity. The most frequent profiles were Ro52+Ro60+SSB (n=349, 43.6%); Ro52+Ro60 (n=126, 15.8%); Ro52 (n=121, 15.1%) and Ro60 (n=71, 8.9%). In samples positive only for SSA and an ANA titer ≤1:640, the most likely profile was positivity for either Ro52 or Ro60, whereas when the ANA titer was >1:640, positivity for both Ro52 and Ro60 simultaneously was more likely (pANA titer (p=0.001). When only SSA was positive and the ANA staining pattern was nucleolar, centromeric or cytoplasmic, Ro52 positivity was most likely (pANA staining pattern. In 28.7% of the patients the profile was variable. Variability was significantly greater in those with the SSA profile (23/67) than with the SSA+SSB profile (15/105; OR=1.9, 95% CI=1.1-3.3; p=0.025), and the difference in variability was greatest between the Ro52+Ro60 profile (8/23) and the Ro52+Ro60+SSB profile (8/68; OR=4.2, 95% CI=1.9-9.5; pANA pattern and titer. In general, for the most frequent anti-ENA findings, priority should be given to retesting autoantibodies not detected in the initial analysis.

  4. Palestiina üritab ÜRO hääletusega riigiks saada / Kaivo Kopli

    Index Scriptorium Estoniae

    Kopli, Kaivo

    2011-01-01

    Palestiina esitab ÜRO-le taotluse võtta Palestiina riik ÜRO liikmeks või tunnistada Palestiinat vaatlejariigina ÜRO juures. Autori sõnul on selge, et USA paneb liikmesriigi-taotlusele veto. Võimalikest probleemidest Palestiinale vaatlejariigi staatuse andmise korral. Skeem: Palestiina pürgimused ÜRO-s

  5. Ku-pa-ro en las tablillas de Cnoso

    Directory of Open Access Journals (Sweden)

    José L. Melena

    1974-12-01

    Full Text Available This paper is intended to be a comprehensive analysis of the evidence of ku-pa-ro in the Knossos Linear B tablets. Its main purpose is to set up the importance of such aromatic plant in the Mycenaean economy at Knossos and to identify what kind of sedge was concealed under the name ku-pa-ro and what part of the plant was used and for what purposes. What it is stressed is the usage of the Cyperus rotundus L. (i. e. the ku-pa-ro in the industry of perfumes and as a food additive as well. What is inferred from the discussion on the evidence of ku-pa-ro issues a series of valuable data concerning the localization of certain place-names in the map of Crete, and concerning the explanation of ideogram *171. The high qualities of ku-pa-ro preserved in the tablets lead the author to assume that such a plant was cultivated in Crete and was one of the main aromatic plants used by the Mycenaeans in the making of perfumes.

  6. CoRoT data reduction by example

    Science.gov (United States)

    Weingrill, J.

    2015-02-01

    Data reduction techniques published so far for the CoRoT N2 data product were targeted primarily on the detection of extrasolar planets. Since the whole dataset has been released, specific algorithms are required to process the lightcurves from CoRoT correctly. Though only unflagged datapoints must be chosen for scientific processing, some flags might be reconsidered. The reduction of data along with improving the signal-to-noise ratio can be achieved by applying a one dimensional drizzle algorithm. Gaps can be filled by linear interpolated data without harming the frequency spectrum. Magnitudes derived from the CoRoT color channels might be used to derive additional information about the targets. Depending on the needs, various filters in the frequency domain remove either the red noise background or high frequency noise. The autocorrelation function or the least squares periodogram are appropriate methods to identify periodic signals. The methods described here are not strictly limited to CoRoT data but may also be applied on Kepler data or the upcoming PLATO mission. The CoRoT space mission, launched on 2006 December 27, has been developed and is operated by CNES, with the contribution of Austria, Belgium, Brazil, ESA (RSSD and Science Programme), Germany and Spain.

  7. CoRoT: harvest of the exoplanet program

    CERN Document Server

    Moutou, Claire; Guillot, Tristan; Baglin, Annie; Bordé, Pascal; Bouchy, François; Cabrera, Juan; Csizmadia, Szilàrd; Deeg, Hans J

    2013-01-01

    One of the objectives of the CoRoT mission is the search for transiting extrasolar planets using high-precision photometry, and the accurate characterization of their fundamental parameters. The CoRoT satellite consecutively observes crowded stellar fields since February 2007, in high-cadence precise photometry; periodic eclipses are detected and analysed in the stellar light curves. Then complementary observations using ground-based facilities allows establishing the nature of the transiting body and its mass. CoRoT has acquired more than 163,000 light curves and detected about 500 planet candidates. A fraction of them (5%) are confirmed planets whose masses are independently measured. Main highlights of the CoRoT discoveries are: i) the variety of internal structures in close-in giant planets, ii) the characterisation of the first known transiting rocky planet, CoRoT-7 b, iii) multiple constraints on the formation, evolution, role of tides in planetary systems.

  8. A [11C]Ro15 4513 PET study suggests that alcohol dependence in man is associated with reduced α5 benzodiazepine receptors in limbic regions.

    Science.gov (United States)

    Lingford-Hughes, Anne; Reid, Alastair G; Myers, James; Feeney, Adrian; Hammers, Alexander; Taylor, Lindsay G; Rosso, Lula; Turkheimer, Federico; Brooks, David J; Grasby, Paul; Nutt, David J

    2012-02-01

    Preclinical evidence suggests the α5 subtype of the GABA-benzodiazepine receptor is involved in some of the actions of alcohol and in memory. The positron emission tomography (PET) tracer, [(11)C]Ro15 4513 shows relative selectivity in labelling the α5 subtype over the other GABA-benzodiazepine receptor subtypes in limbic regions of the brain. We used this tracer to investigate the distribution of α5 subtype availability in human alcohol dependence and its relationship to clinical variables. Abstinent (>6 weeks) alcohol-dependent men and healthy male controls underwent an [(11)C]Ro15 4513 PET scan. We report [(11)C]Ro15 4513 brain uptake for 8 alcohol-dependent men and 11 healthy controls. We found a significant reduction in [(11)C]Ro15 4513 binding in the nucleus accumbens, parahippocampal gyri, right hippocampus and amygdala in the alcohol-dependent compared with the healthy control group. Levels of [(11)C]Ro15 4513 binding in both hippocampi were significantly and positively associated with performance on a delayed verbal memory task in the alcohol-dependent but not the control group. We speculate that the reduced limbic [(11)C]Ro15 4513 binding seen here results from the effects of alcohol, though we cannot currently distinguish whether they are compensatory in nature or evidence of brain toxicity.

  9. Structural and Biochemical Basis for Misfolded RNA Recognition by the Ro Autoantigen

    Energy Technology Data Exchange (ETDEWEB)

    Fuchs,G.; Stein, A.; Fu, C.; Reinisch, K.; Wolin, S.

    2006-01-01

    The Ro autoantigen is ring-shaped, binds misfolded noncoding RNAs and is proposed to function in quality control. Here we determine how Ro interacts with misfolded RNAs. Binding of Ro to misfolded precursor (pre)-5S ribosomal RNA requires a single-stranded 3 end and helical elements. As mutating most sequences of the helices and tail results in modest decreases in binding, Ro may be able to associate with a range of RNAs. Ro binds several other RNAs that contain single-stranded tails. A crystal structure of Ro bound to a misfolded pre-5S rRNA fragment reveals that the tail inserts into the cavity, while a helix binds on the surface. Most contacts of Ro with the helix are to the backbone. Mutagenesis reveals that Ro has an extensive RNA-binding surface. We propose that Ro uses this surface to scavenge RNAs that fail to bind their specific RNA-binding proteins.

  10. Clinical and Pathological Roles of Ro/SSA Autoantibody System

    Directory of Open Access Journals (Sweden)

    Ryusuke Yoshimi

    2012-01-01

    Full Text Available Anti-Ro/SSA antibodies are among the most frequently detected autoantibodies against extractable nuclear antigens and have been associated with systemic lupus erythematosus (SLE and Sjögren's syndrome (SS. Although the presence of these autoantibodies is one of the criteria for the diagnosis and classification of SS, they are also sometimes seen in other systemic autoimmune diseases. In the last few decades, the knowledge of the prevalence of anti-Ro/SSA antibodies in various autoimmune diseases and symptoms has been expanded, and the clinical importance of these antibodies is increasing. Nonetheless, the pathological role of the antibodies is still poorly understood. In this paper, we summarize the milestones of the anti-Ro/SSA autoantibody system and provide new insights into the association between the autoantibodies and the pathogenesis of autoimmune diseases.

  11. Alterations in in-vivo benzodiazepine-receptor binding of C-11-Ro15-1788 (flumazepil)

    Energy Technology Data Exchange (ETDEWEB)

    Yamasaki, T.; Inoue, O.; Shinoto, H.; Ito, T.; Hashimoto, K.; Suzuki, K.; Tateno, Y.

    1985-05-01

    Alterations of the central benzodiazepine - receptor function caused by the change of physiological or psychological conditions, were recognized in both animal and human studies. Before the human study, animal experiments using tritiated Ro15-1788 were carried out. The stress was produced by forcing the mice to swim in a water-basin at 16/sup 0/C for 5 min. Within 3 min after the forced swimming, the tracer was injected. Brain radioactivities in stress-loaded mice increased over a period of 15 min after the intra-venous injection of tracers, while brain activities of carrier-added tracer decreased. In human study, approximately 5 mCi of C-11-Ro15-1788, which specific activity is 0.3-1.0 Ci/..mu..mol, were intravenously injected to each case. Measurements of the brain activity were performed using positron-CT, with blood sample collection. 31 human studies were performed on. Cerebral cortex time activity curves in several volunteers in nervous and stressful state, showed the same pattern to that in the stress-loaded animal experiment. It is important that the significant different time course of cerebral activity after the injection of labelled Ro15-1788, was observed in stressful state, compared with control, in both human and animal study. From these results, it will be concluded the positron CT study using /sup 11/C-Ro15-1788 will become a new technic to detect the change of psychological conditions in human brain and to diagnose some kind of neuropsychiatric disease.

  12. ÜRO peakorterile otsitakse naabrit / Maria-Kristiina Soomre

    Index Scriptorium Estoniae

    Soomre, Maria-Kristiina, 1978-

    2001-01-01

    New Yorki, ÜRO peakorterist lõunasse hakatakse ehitama uut hoonet. Arhitektuurikonkursist on kutsutud osalema: David Childs, Richard Meier ja Peter Eisenmann; Schuman Lichtenstein Claman Efron ja HOK arhitektid; Kohn Pederson Fox, Davis Brody Bond, Toyo Ito ja Rem Koolhaas; Henry Cobb, James Ingo Freed ja Machado & Silvetti Associates; Christian de Portzamparc ja Gary Edward Handel & Associates

  13. [Anti-Ro/SSA antibodies in congenital heart block].

    Science.gov (United States)

    Barrios Prieto, Ernesto; Martínez Ceccopieri, David Alejandro; Panduro Barón, J Guadalupe; Fajardo Dueñas, Sergio

    2012-06-01

    Describe a case of a female patient having anti-Ro/SSA antibodies without any other risk factor or collagen disease. In her first pregnancy a congenital heart block and hydrops in the fetus were diagnosed, and these caused stillbirth. In a second pregnancy an in utero treatment resulted in the succesful delivery of a normal child.

  14. ÜRO peakorterile otsitakse naabrit / Maria-Kristiina Soomre

    Index Scriptorium Estoniae

    Soomre, Maria-Kristiina, 1978-

    2001-01-01

    New Yorki, ÜRO peakorterist lõunasse hakatakse ehitama uut hoonet. Arhitektuurikonkursist on kutsutud osalema: David Childs, Richard Meier ja Peter Eisenmann; Schuman Lichtenstein Claman Efron ja HOK arhitektid; Kohn Pederson Fox, Davis Brody Bond, Toyo Ito ja Rem Koolhaas; Henry Cobb, James Ingo Freed ja Machado & Silvetti Associates; Christian de Portzamparc ja Gary Edward Handel & Associates

  15. News from the CoRoT Space Mission

    CERN Document Server

    Dvorak, R; Lammer, H; Barge, P; Wuchterl, G

    2009-01-01

    The up to 150 day uninterrupted high-precision photometry of about 100000 stars - provided so far by the exoplanet channel of the CoRoT space telescope - gave a new perspective on the planet population of our galactic neighbourhood. The seven planets with very accurate parameters widen the range of known planet properties in almost any respect. Giant planets have been detected at low metallicity, rapidly rotating and active, spotted stars. CoRoT-3 populated the brown dwarf desert and closed the gap of measured physical properties between standard giant planets and very low mass stars. CoRoT extended the known range of planet masses down to 5 Earth masses and up to 21 Jupiter masses, the radii to less than 2 Earth radii and up to the most inflated hot Jupiter found so far, and the periods of planets discovered by transits to 9 days. Two CoRoT planets have host stars with the lowest content of heavy elements known to show a transit hinting towards a different planet-host-star-metallicity relation then the one f...

  16. ÜRO raport tegi Eestist suure narkotootja / Rasmus Kagge

    Index Scriptorium Estoniae

    Kagge, Rasmus, 1977-

    2006-01-01

    ÜRO 2005. aasta narkoraporti andmetel on amfetamiini peamised tootjariigid Euroopas Belgia, Holland ja Poola, kuid tähtsat rolli omavad tootmises ka Bulgaaria, Eesti ja Leedu. Keskkriminaalpolitsei nõuniku Märt Palo hinnangul näitab Eesti mainimine raportis, et Eesti politsei on oma tulemustega narkootikumide vastases võitluses silma paistnud. Tabel: Narkovõitlus

  17. ÜRO rahuvalvemissiooni juhtinud brasiillane leiti Haiti hotellist surnult / Heiki Suurkask

    Index Scriptorium Estoniae

    Suurkask, Heiki, 1972-

    2006-01-01

    ÜRO Haiti rahuvalvemissiooni juht Urano Teixeira da Matta Bacellar sooritas enesetapu. ÜRO rahuvalvemissioon MINUSTAH on Haitil 2005. aastast pärast nelja-aastast eemalolekut, samas jätkub seal vägivald

  18. ÜRO rahuvalvemissiooni juhtinud brasiillane leiti Haiti hotellist surnult / Heiki Suurkask

    Index Scriptorium Estoniae

    Suurkask, Heiki, 1972-

    2006-01-01

    ÜRO Haiti rahuvalvemissiooni juht Urano Teixeira da Matta Bacellar sooritas enesetapu. ÜRO rahuvalvemissioon MINUSTAH on Haitil 2005. aastast pärast nelja-aastast eemalolekut, samas jätkub seal vägivald

  19. Common and Specific Associations of Anti-SSA/Ro60 and Anti-Ro52/TRIM21 Antibodies in Systemic Lupus Erythematosus

    Directory of Open Access Journals (Sweden)

    Aurora Menéndez

    2013-01-01

    Full Text Available Little information exists about the association of anti-SSA/Ro60 and anti-Ro52/TRIM21 with systemic lupus erytematosus (SLE features. In this work, we analysed the associations of both anti-Ro reactivities with clinical and immunological manifestations in 141 SLE patients. Photosensitivity and xerophtalmia/xerostomia were found to be positively associated with both anti-SSA/Ro60 (P=0.024 and P=0.019, resp. and anti-Ro52/TRIM21 (P=0.026 and P=0.022, resp.. In contrast, a negative association was detected regarding anti-phospholipid antibodies, anti-SSA/Ro60 having a stronger effect (P=0.014 than anti-Ro52/TRIM21. Anti-SSA/Ro60 showed a specific positive association with hypocomplementemia (P=0.041, mainly with low C4 levels (P=0.008, whereas anti-Ro52/TRIM21 was found to be positively associated with Raynaud’s phenomenon (P=0.026 and cytopenia (P=0.048 and negatively associated with anti-dsDNA (P=0.013. Lymphocytes are involved in the relationship between anti-Ro52/TRIM21 and cytopenia since positive patients showed lower cell levels than negative patients (P=0.036. In conclusion, anti-SSA/Ro60 and anti-Ro52/TRIM21 showed both common and specific associations in SLE. These data thus increase evidence of the different associations of the two anti-Ro specificities even in a particular disease.

  20. Comparison of antibody assays for detection of autoantibodies to Ro 52, Ro 60 and La associated with primary Sjögren's syndrome.

    Science.gov (United States)

    Trier, Nicole Hartwig; Nielsen, Inger Ødum; Friis, Tina; Houen, Gunnar; Theander, Elke

    2016-06-01

    Anti-Ro(52/60) and anti-La constitute the hallmark autoantibodies in primary Sjögren's syndrome, being present in 40-70% of sera. Several anti-Ro/La assays exist, but antibody detection appears to be assay-specific, thus the aim of this study was to compare several anti-Ro/La assays. In total, 96 sera from individuals with primary Sjögren's syndrome and 114 healthy controls were tested for anti-Ro 52/60 and anti-La in 17 immunoassays. Especially the immunoassays used for detection of anti-Ro 52 differed in their sensitivity (48-79%), while only small differences in sensitivities were observed for the anti-Ro 60 (69-77%) anti-La (39-44%) assays. Concordances of 65%, 79% and 73% for the anti-Ro 52, anti-Ro 60 and anti-La assays were found, respectively. The majority of the assays yielded high specificities, primarily ranging from 97 to 100%, except from a single anti-Ro 60 assay, which yielded a specificity of 79%. Occasionally, reactivity levels were increased in a few assays, indicating that false-positive results can be obtained when applying assays of reduced specificity. In general, the commercial assays appeared to perform better than the in-house analyses. When correcting the in-house assays for background reactivity, sensitivities were reduced by approximately 7%, 17%, and 19% for anti-Ro 52, anti-Ro 60 and anti-La assays, respectively, illustrating the pitfalls when applying immunoassays for detection of autoantibodies, which in theory may apply to commercial assays as well. Finally, increased total sensitivities were obtained when combining assays. These studies contribute to clarify the clinical utility of immunoassays for detection of autoantibodies of Ro 52, Ro 60 and La and illustrate that the most efficient strategy to maximize antibody sensitivity is to combine several assays.

  1. Ceftobiprole Medocaril: BAL5788, JNJ 30982081, JNJ30982081, RO 65-5788, RO 655788.

    Science.gov (United States)

    2006-01-01

    Ceftobiprole medocaril [BAL 5788, RO 65-5788, JNJ 30982081] is a prodrug in phase III clinical development with Basilea Pharmaceutica and Cilag AG (Johnson & Johnson) for the potential treatment of serious bacterial infections, including methicillin-resistant Staphylococcus aureus (MRSA). Ceftobiprole medocaril is the water-soluble prodrug of the pyrrolidinone cephalosporin, ceftobiprole [BAL 9141, RO 63-9141]. Because of the low water solubility of ceftobiprole, its clinical application was limited and Basilea began its investigations into ceftobiprole medocaril for further development. Ceftobiprole medocaril is being developed for IV administration and is currently undergoing phase III trials for complicated skin and skin structure infections (including MRSA) and hospital-acquired (nosocomial) pneumonia. Ceftobiprole medocaril has a broad spectrum of activity against Gram-positive bacteria (including methicillin-resistant staphylococci, penicillin-resistant pneumococci and Enterococcus faecalis) and Gram-negative bacteria. Ceftobiprole medocaril inhibits all transpeptidases, including the penicillin-binding protein (PBP) 2a, by a unique combination of features. PBP 2a is the primary enzyme responsible for beta-lactam drug resistance in MRSA; PBP 2a also acts as a key defense mechanism by interacting with the bacterial cell wall to form a chemical barricade that is impervious to antibiotics. Ceftobiprole medocaril has been designed specifically to bind to this penicillin-resistant target. Ceftobiprole medocaril is bactericidal and has not shown resistance development in vitro or in stringent animal models. Studies conducted by Basilea have demonstrated that ceftobiprole medocaril is readily converted to ceftobiprole, and shows markedly improved water solubility. In February 2005, Basilea Pharmaceutica AG entered into an exclusive worldwide agreement with Cilag AG International (Johnson & Johnson) to develop, manufacture and market ceftobiprole medocaril. Ortho

  2. ÜRO asesekretäri kriitika USA suunal ajas viimase marru / Liise Lehtsalu

    Index Scriptorium Estoniae

    Lehtsalu, Liise

    2006-01-01

    ÜRO asesekretär Malloch Brown kritiseeris oma kõnes USA tahtmatust teavitada ameeriklasi ÜRO osast USA välispoliitikas. USA ÜRO-suursaadiku John Boltoni reageering Browni märkustele. Lisa: Rikaste ja vaeste riikide vastuolud

  3. ÜRO asesekretäri kriitika USA suunal ajas viimase marru / Liise Lehtsalu

    Index Scriptorium Estoniae

    Lehtsalu, Liise

    2006-01-01

    ÜRO asesekretär Malloch Brown kritiseeris oma kõnes USA tahtmatust teavitada ameeriklasi ÜRO osast USA välispoliitikas. USA ÜRO-suursaadiku John Boltoni reageering Browni märkustele. Lisa: Rikaste ja vaeste riikide vastuolud

  4. Sõjaraport õõnestab ÜRO usaldusväärsust / Jürgen Tamme

    Index Scriptorium Estoniae

    Tamme, Jürgen

    2011-01-01

    ÜRO Gaza sõda puudutavas raportis kritiseeritakse nii Iisraeli kui ka Palestiina islamistlikku äärmusrühmitust Hamas. ÜRO inimõiguste uurija Richard Goldstone leiab, et raport on siiski puudulik, kuna praegu omab ÜRO juba rohkem infot Gaza sõja kohta

  5. Haitilased süüdistavad kooleras ÜRO rahuvalvajaid

    Index Scriptorium Estoniae

    2010-01-01

    Paljud kohalikud elanikud on veendunud, et Haiti kooleraepideemia vallandamises on süüdi ÜRO stabilisatsioonimission MINUSTAH. Riigis on puhkenud ÜRO-vastased rahutused. ÜRO arvates on protestilaine algatatud presidendivalimisi nurjata soovivate poliitiliste liikumiste poolt

  6. Haitilased süüdistavad kooleras ÜRO rahuvalvajaid

    Index Scriptorium Estoniae

    2010-01-01

    Paljud kohalikud elanikud on veendunud, et Haiti kooleraepideemia vallandamises on süüdi ÜRO stabilisatsioonimission MINUSTAH. Riigis on puhkenud ÜRO-vastased rahutused. ÜRO arvates on protestilaine algatatud presidendivalimisi nurjata soovivate poliitiliste liikumiste poolt

  7. Sõjaraport õõnestab ÜRO usaldusväärsust / Jürgen Tamme

    Index Scriptorium Estoniae

    Tamme, Jürgen

    2011-01-01

    ÜRO Gaza sõda puudutavas raportis kritiseeritakse nii Iisraeli kui ka Palestiina islamistlikku äärmusrühmitust Hamas. ÜRO inimõiguste uurija Richard Goldstone leiab, et raport on siiski puudulik, kuna praegu omab ÜRO juba rohkem infot Gaza sõja kohta

  8. Isolated anti-Ro/SSA thrombocytopenia: a rare feature of neonatal lupus.

    Science.gov (United States)

    Ayadi, Imene Dahmane; Ben Hamida, Emira; Boukhris, Mohamed Riadh; Bezzine, Ahlem; Chaouachi, Sihem; Marrakchi, Zahra

    2015-01-01

    We report a rare case of isolated thrombocytopenia related to anti-Ro/SSA antibodies. The mother was followed for unlabeled familial thrombocytopenia. The mother had positive anti-Ro/SSA antibodies. She was asymptomatic without skin lesions or other criteria neither of systemic lupus erythematosus nor other connective tissue disease. Pregnancy was uneventful. The postnatal examination was normal. On the first day of life, blood cells count showed thrombocytopenia at 40 x 10(9)/L. Within the second day of life, platelet level dropped to 20 x 10(9)/L. The management of thrombocytopenia included platelet transfusion and human immunoglobulin infusion. On the fifth day of life, there has been a drop in platelet count to 10 x 10(9)/L requiring renewed platelet transfusion and human immunoglobulin infusion. On the 10(th) of life platelets rate was stable around 60 x 10(9)/L. The infant had no evidence of cardiac, dermatologic or hepatobilary involvement initially or throughout follow up.

  9. Mejora del plan de eficiencia energética para el buque RO-RO Galicia sustituyendo su alumbrado fluorescente por tecnología led

    OpenAIRE

    2016-01-01

    Resumen: ENERGÉTICA PARA EL BUQUE RO-RO GALICIA SUSTITUYENDO SU ALUMBRADO FLUORESCENTE POR TECNOLOGÍA LED”, es un trabajo académico que focaliza la herramienta tecnológica LED, integrándola en el equipo de iluminación de un buque RO-RO para conseguir mejorar su eficiencia energética. Los equipos de iluminación han sufrido una espectacular mejora con la incorporación de los sistemas LED, permitiendo ahorrar grandes cantidades de energía, incrementando la vida útil de las luminarias y reduciend...

  10. Detection of small-size planetary candidates with CoRoT data

    Directory of Open Access Journals (Sweden)

    Moutou C.

    2011-02-01

    Full Text Available With the discovery of CoRoT-7b, the first transiting super-Earth, the CoRoT space mission has shown the capability to detect short-period rocky planets around solar-like stars. By performing a blind test with real CoRoT light curves, we want to establish the detection threshold of small-size planets in CoRoT data. We investigate the main obstacles to the detection of transiting super-Earths in CoRoT data, notably the presence of short-time scale variability and hot pixels.

  11. Transiting exoplanets from the CoRoT space mission

    DEFF Research Database (Denmark)

    Ollivier, M.; Gillon, M.; Santerne, A.

    2012-01-01

    Aims. We report the discovery of CoRoT-16b, a low density hot jupiter that orbits a faint G5V star (mV = 15.63) in 5.3523 ± 0.0002 days with slight eccentricity. A fit of the data with no a priori assumptions on the orbit leads to an eccentricity of 0.33 ± 0.1. We discuss this value and also deri...

  12. THE MASS OF CoRoT-7b

    Energy Technology Data Exchange (ETDEWEB)

    Hatzes, Artie P.; Wuchterl, Guenther [Thueringer Landessternwarte, D-07778 Tautenburg (Germany); Fridlund, Malcolm; Gandolfi, Davide [European Space Agency, ESTEC, SRE-SA, P.O. Box 299, NL-2200AG, Noordwijk (Netherlands); Nachmani, Gil; Mazeh, Tsevi [School of Physics and Astronomy, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv (Israel); Valencia, Diana [Observatoire de la Cote d' Azur, BP 4229, F-06304 Nice Cedex 4 (France); Hebrard, Guillaume; Borde, Pascal [Institut d' Astrophysique de Paris, UMR 7095 CNRS, Universite Pierre and Marie Curie, 98bis boulevard Arago, F-75014 Paris (France); Carone, Ludmila; Paetzold, Martin [Rheinisches Institut fuer Umweltforschung, Universitaet zu Koeln, Abt. Planetenforschung, Aachener Str. 209, D-50931 Koeln (Germany); Udry, Stephane [Observatoire de l' Universite de Geneve, 51 chemin des Maillettes, 1290 Sauverny (Switzerland); Bouchy, Francois [Observatoire de Haute Provence, F-04670 Saint Michel l' Observatoire (France); Deleuil, Magali; Moutou, Claire; Barge, Pierre [Laboratoire d' Astrophysique de Marseille, CNRS and University of Provence, 38 rue Frederic Joliot-Curie, F-13388 Marseille Cedex 13 (France); Deeg, Hans; Tingley, Brandon [Instituto de Astrofisica de Canarias, E-38205 La Laguna, Tenerife (Spain); Dvorak, Rudolf [University of Vienna, Institute of Astronomy, Tuerkenschanzstr. 17, A-1180, Vienna (Austria); Ferraz-Mello, Sylvio, E-mail: artie@tls-tautenburg.de, E-mail: malcolm.fridlund@esa.int [IAG, University of Sao Paulo (Brazil); and others

    2011-12-10

    The mass of CoRoT-7b, the first transiting super-Earth exoplanet, is still a subject of debate. A wide range of masses have been reported in the literature ranging from as high as 8 M{sub Circled-Plus} to as low as 2.3 M{sub Circled-Plus }. This range in mass is largely due to the activity level of the star that contributes a significant amount of radial velocity (RV) 'jitter' and how the various methods correct this jitter. Although most mass determinations give a density consistent with a rocky planet, the lower value permits a bulk composition that can be up to 50% water. We present an analysis of the CoRoT-7b RV measurements that uses very few and simple assumptions in treating the activity signal. By analyzing those RV data for which multiple measurements were made in a given night, we remove the activity related RV contribution without any a priori model. We argue that the contribution of activity to the final RV curve is negligible and that the K-amplitude due to the planet is well constrained. This yields a mass of 7.42 {+-} 1.21 M{sub Circled-Plus} and a mean density of {rho} = 10.4 {+-} 1.8 gm cm{sup -3}. CoRoT-7b is similar in mass and radius to the second rocky planet to be discovered, Kepler-10b, and within the errors they have identical bulk densities-they are virtual twins. These bulk densities lie close to the density-radius relationship for terrestrial planets similar to what is seen for Mercury. CoRoT-7b and Kepler-10b may have an internal structure more like Mercury than the Earth.

  13. Mundos de roças e florestas

    Directory of Open Access Journals (Sweden)

    Joana Cabral de Oliveira

    Full Text Available Resumo Pretendo explorar neste artigo as relações entre os domínios da roça (koo e da floresta (ka’a, importante oposição da cosmologia wajãpi (grupo Tupi que habita o estado do Amapá. Ka’a e koo, contudo, não se constituem como uma oposição fixa, mas antes como posições relacionais que se movem, nas quais a capoeira ocupa um papel fundamental. Algo que é evidenciado tanto numa dinâmica de ocupação territorial - por meio do cultivo de áreas de mata primária e o abandono dos roçados após a colheita -, quanto por meio das relações perspectivistas que movimentam as categorias de roça e floresta, plantas cultivadas e não-cultivadas, através de distintos sujeitos. Nesse contexto, compreender a dinâmica das relações entre floresta e roçado é fundamental para melhor refletir sobre como algumas famílias wajãpi entendem a atividade agrícola. Proponho essa reflexão estabelecendo um diálogo com ecologia histórica que aponta para a existência de florestas antropizadas, contexto em que a agricultura se apresenta como uma atividade central para a produção de biodiversidade.

  14. The Mass of CoRoT-7b

    Science.gov (United States)

    Hatzes, Artie P.; Fridlund, Malcolm; Nachmani, Gil; Mazeh, Tsevi; Valencia, Diana; Hébrard, Guillaume; Carone, Ludmila; Pätzold, Martin; Udry, Stephane; Bouchy, Francois; Deleuil, Magali; Moutou, Claire; Barge, Pierre; Bordé, Pascal; Deeg, Hans; Tingley, Brandon; Dvorak, Rudolf; Gandolfi, Davide; Ferraz-Mello, Sylvio; Wuchterl, Günther; Guenther, Eike; Guillot, Tristan; Rauer, Heike; Erikson, Anders; Cabrera, Juan; Csizmadia, Szilard; Léger, Alain; Lammer, Helmut; Weingrill, Jörg; Queloz, Didier; Alonso, Roi; Rouan, Daniel; Schneider, Jean

    2011-12-01

    The mass of CoRoT-7b, the first transiting super-Earth exoplanet, is still a subject of debate. A wide range of masses have been reported in the literature ranging from as high as 8 M ⊕ to as low as 2.3 M ⊕. This range in mass is largely due to the activity level of the star that contributes a significant amount of radial velocity (RV) "jitter" and how the various methods correct this jitter. Although most mass determinations give a density consistent with a rocky planet, the lower value permits a bulk composition that can be up to 50% water. We present an analysis of the CoRoT-7b RV measurements that uses very few and simple assumptions in treating the activity signal. By analyzing those RV data for which multiple measurements were made in a given night, we remove the activity related RV contribution without any a priori model. We argue that the contribution of activity to the final RV curve is negligible and that the K-amplitude due to the planet is well constrained. This yields a mass of 7.42 ± 1.21 M ⊕ and a mean density of ρ = 10.4 ± 1.8 gm cm-3. CoRoT-7b is similar in mass and radius to the second rocky planet to be discovered, Kepler-10b, and within the errors they have identical bulk densities—they are virtual twins. These bulk densities lie close to the density-radius relationship for terrestrial planets similar to what is seen for Mercury. CoRoT-7b and Kepler-10b may have an internal structure more like Mercury than the Earth.

  15. Ro60 and La ribonucleoproteins become self-aggregated by cell stress

    Directory of Open Access Journals (Sweden)

    E. Avalos-Díaz

    2011-09-01

    Full Text Available Ro is a cellular particle composed by three ribonucleoproteins of 60, 54 and 52 kDa (1-3. Ro60 forms a complex with one of the 1-5 hYRNAs (4. Antigenic properties of Ro were described by Clark in 1969 using autoimmune sera (5, and it is broadly accepted that Ro is recognized by autoantibodies from patients with systemic lupus erythematosus (SLE, subacute cutaneous lupus erythematosus (SCLE, Sjögren’s syndrome (SS and neonatal lupus (6. Complexes of Ro are involved in the transcription quality control of 5S rRNA, Ro60 bind the 5S rRNA inefficient transcribed to be eliminated (7, 8. Ro is expressed broadly in nucleus and cytoplasm of eukaryotic cells (9-11.

  16. High performance RO membranes for desalination and wastewater reclamation and their operation results.

    Science.gov (United States)

    Henmi, M; Fusaoka, Y; Tomioka, H; Kurihara, M

    2010-01-01

    Reverse osmosis (RO) membrane is one of the most powerful tools for solving the global water crisis, and is used in a variety of water treatment scenes such as drinking water purification, waste-water treatment, boiler feed water production, ultra pure water production for semiconductor industry, etc. The desired performance of RO membrane varies according to quality of feed water being treated, and Toray has been developing RO membranes with suitable characteristic for each operating condition. RO membranes for seawater desalination and wastewater reclamation are especially regarded as most promising targets. Recently, high boron removal and energy saving RO membrane for seawater desalination and low fouling RO membrane for wastewater reclamation have been developed. In this paper, the prospect of attaining these renovative RO membrane, and furthermore, job references will be discussed.

  17. Transit timing analysis of CoRoT-1b

    CERN Document Server

    Csizmadia, Sz; Barge, P; Agol, E; Aigrain, S; Alonso, R; Almenara, J M; Bonomo, A S; Borde, P; Bouchy, F; Cabrera, J; Deeg, H J; De la Reza, R; Deleuil, M; Dvorak, R; Erikson, A; Guenther, E W; Fridlund, M; Gondoin, P; Guillot, T; Hatzes, A; Jorda, L; Lammer, H; Lázaro, C; Leger, A; Llebaria, A; Magain, P; Moutou, C; Ollivier, M; Paetzold, M; Queloz, D; Rauer, H; Rouan, D; Schneider, J; Wuchterl, G; Gandolfi, D

    2009-01-01

    CoRoT, the pioneer space-based transit search, steadily provides thousands of high-precision light curves with continuous time sampling over periods of up to 5 months. The transits of a planet perturbed by an additional object are not strictly periodic. By studying the transit timing variations (TTVs), additional objects can be detected in the system. A transit timing analysis of CoRoT-1b is carried out to constrain the existence of additional planets in the system. We used data obtained by an improved version of the CoRoT data pipeline (version 2.0). Individual transits were fitted to determine the mid-transit times, and we analyzed the derived $O-C$ diagram. N-body integrations were used to place limits on secondary planets. No periodic timing variations with a period shorter than the observational window (55 days) are found. The presence of an Earth-mass Trojan is not likely. A planet of mass greater than $\\sim 1$ Earth mass can be ruled out by the present data if the object is in a 2:1 (exterior) mean mot...

  18. Stellar classification of CoRoT targets

    CERN Document Server

    Damiani, C; Moutou, C; Deleuil, M; Ysard, N; Baudin, F; Deeg, H

    2016-01-01

    The CoRoT faint stars channel observed about 163 600 targets to detect transiting planetary companions. Because CoRoT targets are faint (11< r <16) and close to the galactic plane, only a small subsample has been observed spectroscopically. We describe the latest classification scheme used to derive the spectral type of CoRoT targets, which is based on broadband multi-colour photometry. We assess the accuracy of this spectral classification for the first time. We find that the classification method performs better for stars that were observed during the mission-dedicated photometric ground-based campaigns.The luminosity class is wrong for less than 7% of the targets. Generally, the effective temperature of stars classified as early type (O, B, and A) is overestimated. Conversely, the temperature of stars classified as later type tends to be underestimated. This is mainly due to the adverse effect of interstellar reddening. We find that the median error on the effective temperature is less than 5% for dw...

  19. On the Mass of CoRoT-7b

    CERN Document Server

    Hatzes, Artie P; Nachmani, Gil; Mazeh, Tsevi; Valencia, Diana; Hebrard, Guillaume; Carone, Ludmila; Paetzold, Martin; Udry, Stephane; Bouchy, Francois; Borde, Pascal; Deeg, Hans; Tingley, Brandon; Dvorak, Rudolf; Gandolfi, Davide; Ferraz-Mello, Sylvio; Wuchterl, Guenther; Guenther, Eike; Rauer, Heike; Erikson, Anders; Cabrera, Juan; Csizmadia, Szilard; Leger, Alain; Lammer, Helmut; Weingrill, Joerg; Queloz, Didier; Alonso, Roi; Schneider, Jean

    2011-01-01

    The mass of CoRoT-7b, the first transiting superearth exoplanet, is still a subject of debate. A wide range of masses have been reported in the literature ranging from as high as 8 M_Earth to as low as 2.3 M_Earth. Although most mass determinations give a density consistent with a rocky planet, the lower value permits a bulk composition that can be up to 50% water. We present an analysis of the CoRoT-7b radial velocity measurements that uses very few and simple assumptions in treating the activity signal. By only analyzing those radial velocity data for which multiple measurements were made in a given night we remove the activity related radial velocity contribution without any a priori model. We demonstrate that the contribution of activity to the final radial velocity curve is negligible and that the K-amplitude due to the planet is well constrained. This yields a mass of 7.42 +/- 1.21 M_Earth and a mean density of rho = 10.4 +/- 1.8 gm cm^-3. CoRoT-7b is similar in mass and radius to the second rocky plane...

  20. The secondary eclipse of CoRoT-1b

    CERN Document Server

    Alonso, R; Aigrain, S; Auvergne, M; Baglin, A; Barbieri, M; Barge, P; Bonomo, A S; Borde, P; Bouchy, F; Chaintreuil, S; De la Reza, R; Deeg, H J; Deleuil, M; Dvorak, R; Erikson, A; Fridlund, M; Fialho, F; Gondoin, P; Guillot, T; Hatzes, A; Jorda, L; Lammer, H; Léger, A; Llebaria, A; Magain, P; Mazeh, T; Moutou, C; Ollivier, M; Patzold, M; Pont, F; Queloz, D; Rauer, H; Rouan, D; Schneider, J; Wuchterl, G

    2009-01-01

    The transiting planet CoRoT-1b is thought to belong to the pM-class of planets, in which the thermal emission dominates in the optical wavelengths. We present a detection of its secondary eclipse in the CoRoT white channel data, whose response function goes from ~400 to ~1000 nm. We used two different filtering approaches, and several methods to evaluate the significance of a detection of the secondary eclipse. We detect a secondary eclipse centered within 20 min at the expected times for a circular orbit, with a depth of 0.016+/-0.006%. The center of the eclipse is translated in a 1-sigma upper limit to the planet's eccentricity of ecosomega<0.014. Under the assumption of a zero Bond Albedo and blackbody emission from the planet, it corresponds to a T_{CoRoT}=2330 +120-140 K. We provide the equilibrium temperatures of the planet as a function of the amount of reflected light. If the planet is in thermal equilibrium with the incident flux from the star, our results imply an inefficient transport mechanism ...

  1. Danish WEEE management in the light of the WEEE and RoHS Directives: a quantitative analysis of critical issues

    DEFF Research Database (Denmark)

    Pizzol, Massimo; Thomsen, Marianne

    Waste from Electrical and Electronic Equipment (WEEE) is the fastest growing waste fraction in Europe and is classified as hazardous as it may include substances that have adverse effects on human health or cause damage to the environment (UNEP, 2009). The European Community Directive 2002/96/EC...... on Waste Electrical and Electronic Equipment (WEEE Directive), together with the European Community Directive 2002/95/EC on the Restriction of Hazardous Substances (RoHS Directive) were established respectively to set collection, recycling and recovery targets, and to restrict the use of six hazardous......HS directive, flows of toxic compounds are still significant in WEEE, as can be demonstrated by performing a Substance Flow Analysis (SFA) (Brunner, 2004) on a Danish WEEE treatment facility. This is due to the presence, in the WEEE, of devices constituting an exception to the RoHS directive and of other...

  2. Transiting exoplanets from the CoRoT space mission . XIX. CoRoT-23b: a dense hot Jupiter on an eccentric orbit

    DEFF Research Database (Denmark)

    Rouan, D.; Parviainen, H.; Moutou, C.

    2012-01-01

    We report the detection of CoRoT-23b, a hot Jupiter transiting in front of its host star with a period of 3.6314 ± 0.0001 days. This planet was discovered thanks to photometric data secured with the CoRoT satellite, combined with spectroscopic radial velocity (RV) measurements. A photometric sear...

  3. Transiting exoplanets from the CoRoT space mission . XIX. CoRoT-23b: a dense hot Jupiter on an eccentric orbit

    DEFF Research Database (Denmark)

    Rouan, D.; Parviainen, H.; Moutou, C.

    2012-01-01

    We report the detection of CoRoT-23b, a hot Jupiter transiting in front of its host star with a period of 3.6314 ± 0.0001 days. This planet was discovered thanks to photometric data secured with the CoRoT satellite, combined with spectroscopic radial velocity (RV) measurements. A photometric sear...

  4. Transiting exoplanets from the CoRoT space mission. XXIII. CoRoT-21b: a doomed large Jupiter around a faint subgiant star

    DEFF Research Database (Denmark)

    Pätzold, M.; Endl, M.; Csizmadia, Sz.;

    2012-01-01

    CoRoT-21, a F8IV star of magnitude V = 16 mag, was observed by the space telescope CoRoT during the Long Run 01 (LRa01) in the first winter field (constellation Monoceros) from October 2007 to March 2008. Transits were discovered during the light curve processing. Radial velocity follow-up observ...

  5. SS-A/Ro52 promotes apoptosis by regulating Bcl-2 production

    Energy Technology Data Exchange (ETDEWEB)

    Jauharoh, Siti Nur Aisyah [Department of Clinical Pathology and Immunology, Kobe University Graduate School of Medicine, Hyogo 650-0017 (Japan); Faculty of Medicine and Health Science, Syarif Hidayatullah State Islamic University, Jakarta 15412 (Indonesia); Saegusa, Jun; Sugimoto, Takeshi [Department of Clinical Pathology and Immunology, Kobe University Graduate School of Medicine, Hyogo 650-0017 (Japan); Ardianto, Bambang [Department of Clinical Pathology and Immunology, Kobe University Graduate School of Medicine, Hyogo 650-0017 (Japan); Department of Child Health, Faculty of Medicine, Gadjah Mada University, Yogyakarta 55282 (Indonesia); Kasagi, Shimpei; Sugiyama, Daisuke; Kurimoto, Chiyo [Department of Clinical Pathology and Immunology, Kobe University Graduate School of Medicine, Hyogo 650-0017 (Japan); Tokuno, Osamu; Nakamachi, Yuji [Department of Laboratory Medicine, Kobe University Hospital, Hyogo 650-0017 (Japan); Kumagai, Shunichi [Department of Clinical Pathology and Immunology, Kobe University Graduate School of Medicine, Hyogo 650-0017 (Japan); Kawano, Seiji, E-mail: sjkawano@med.kobe-u.ac.jp [Department of Clinical Pathology and Immunology, Kobe University Graduate School of Medicine, Hyogo 650-0017 (Japan); Department of Laboratory Medicine, Kobe University Hospital, Hyogo 650-0017 (Japan)

    2012-01-06

    Highlights: Black-Right-Pointing-Pointer Ro52{sup low} HeLa cells are resistant to apoptosis upon various stimulations. Black-Right-Pointing-Pointer Ro52 is upregulated by IFN-{alpha}, etoposide, or IFN-{gamma} and anti-Fas Ab. Black-Right-Pointing-Pointer Ro52-mediated apoptosis is independent of p53. Black-Right-Pointing-Pointer Ro52 selectively regulates Bcl-2 expression. -- Abstract: SS-A/Ro52 (Ro52), an autoantigen in systemic autoimmune diseases such as systemic lupus erythematosus and Sjoegren's syndrome, has E3 ligase activity to ubiquitinate proteins that protect against viral infection. To investigate Ro52's role during stress, we transiently knocked it down in HeLa cells by siRo52 transfection. We found that Ro52{sup low} HeLa cells were significantly more resistant to apoptosis than wild-type HeLa cells when stimulated by H{sub 2}O{sub 2}- or diamide-induced oxidative stress, IFN-{alpha}, IFN-{gamma} and anti-Fas antibody, etoposide, or {gamma}-irradiation. Furthermore, Ro52-mediated apoptosis was not influenced by p53 protein level in HeLa cells. Depleting Ro52 in HeLa cells caused Bcl-2, but not other Bcl-2 family molecules, to be upregulated. Taken together, our data showed that Ro52 is a universal proapoptotic molecule, and that its proapoptotic effect does not depend on p53, but is exerted through negative regulation of the anti-apoptotic protein Bcl-2. These findings shed light on a new physiological role for Ro52 that is important to intracellular immunity.

  6. Anti-SLA/LP alone or in combination with anti-Ro52 and fine specificity of anti-Ro52 antibodies in patients with autoimmune hepatitis.

    Science.gov (United States)

    Zachou, Kalliopi; Gampeta, Stella; Gatselis, Nikolaos K; Oikonomou, Katerina; Goulis, John; Manoussakis, Menelaos N; Renaudineau, Yves; Bogdanos, Dimitrios P; Dalekos, George N

    2015-02-01

    Antibodies (Abs) to soluble liver antigen/liver pancreas (anti-SLA/LP) are considered markers of worse prognosis and outcome in patients with autoimmune hepatitis (AIH) although this assumption has recently been attributed to their frequent co-expression with Abs against Ro52 (anti-Ro52). To assess the clinical significance of anti-SLA/LP Abs alone or in combination with anti-Ro52 in AIH patients and determine the immunodominant Ro52 epitopes according to the anti-SLA/LP status. Twenty-three anti-SLA/LP-positive and 106 anti-SLA/LP-negative AIH patients were included. Anti-SLA/LP were determined by ELISA using recombinant antigen, and confirmed by immunoblot using cytosolic rat liver fraction or HuH-7 extract. Anti-Ro52 Abs were determined by ELISA using recombinant antigen. Epitope mapping was assessed by ELISA using overlapping peptides covering the whole Ro52 protein in 26 AIH patients and 12 patients with Sjögren's syndrome. Anti-SLA/LP positivity was not associated with the clinical, laboratory or histological characteristics of AIH patients. Treatment response, corticosteroid withdrawal, relapse after stopping treatment and outcome, were not associated with the presence of anti-SLA/LP, anti-Ro52 or double reactivity. Moreover, Ro52 epitope mapping revealed new epitopes unique for AIH and independent from anti-SLA/LP positivity. Neither anti-SLA/LP nor anti-Ro52 Abs or their combination could specify a distinct group of AIH patients in terms of clinical characteristics, treatment response and outcome. Further studies are needed to clarify whether the newly discovered immunodominant epitopes of Ro52 antigen which were associated specifically with AIH have any clinical or pathogenetic significance in AIH. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  7. RETRACTED: Blockade of TNF-α signaling suppresses the AREG-mediated IL-6 and IL-8 cytokines secretion induced by anti-Ro/SSA autoantibodies.

    Science.gov (United States)

    Sisto, Margherita; Lisi, Sabrina; Lofrumento, Dario Domenico; Cucci, Liana; Mitolo, Vincenzo; D'Amore, Massimo

    2010-09-20

    The aim of this study was to analyze the Furin-TNF-α-converting enzyme (TACE)-amphiregulin (AREG)-IL-6/IL-8 secretion pathway in non-neoplastic human salivary gland epithelial cells (SGECs) stimulated with anti-Ro/SSA autoantibodies (Abs). We examined whether anti-Ro/SSA Abs-mediated TACE activation is responsible for AREG activation. As recent studies have demonstrated that AREG could induce proinflammatory cytokines secretion in epithelial cells, we discuss how TACE-mediated AREG shedding, caused by anti-Ro/SSA Abs treatment, could have a critical role in TNF-α-induced IL-6 and IL-8 secretion by SGEC. Furthermore, the effects of TNF-α blockade on AREG expression and TNF-α-AREG-mediated IL-6 and IL-8 secretion were evaluated. We have discovered that the upregulation of AREG occurs through TNF-α produced after anti-Ro/SSA Abs uptake via Fcγ receptors. Biological drug adalimumab and the gene silencing technique were used to study the AREG-IL-6/IL-8 secretion pathway, demonstrating that (i) adalimumab-mediated TNF-α blocking and TNF-α gene silencing provoke a significant decrease of proinflammatory cytokines production and AREG expression in anti-Ro/SSA Abs-treated SGEC; (ii) AREG gene silencing has a potent inhibitory effect on TNF-α-induced IL-6 and IL-8 secretion in SGEC treated with anti-Ro/SSA Abs; (iii) an inspection of the kinetics of cytokine production after exogeni TNF-α and AREG addition, and the use of cycloheximide in the presence of exogenous TNF-α as stimulant, clarified that TNF-α induces IL-6 and IL-8 secretion through AREG.Laboratory Investigation advance online publication, 20 September 2010; doi:10.1038/labinvest.2010.168.

  8. Dispersion and nonlinear effects in OFDM-RoF system

    Science.gov (United States)

    Alhasson, Bader H.; Bloul, Albe M.; Matin, M.

    2010-08-01

    The radio-over-fiber (RoF) network has been a proven technology to be the best candidate for the wireless-access technology, and the orthogonal frequency division multiplexing (OFDM) technique has been established as the core technology in the physical layer of next generation wireless communication system, as a result OFDM-RoF has drawn attentions worldwide and raised many new research topics recently. At the present time, the trend of information industry is towards mobile, wireless, digital and broadband. The next generation network (NGN) has motivated researchers to study higher-speed wider-band multimedia communication to transmit (voice, data, and all sorts of media such as video) at a higher speed. The NGN would offer services that would necessitate broadband networks with bandwidth higher than 2Mbit/s per radio channel. Many new services emerged, such as Internet Protocol TV (IPTV), High Definition TV (HDTV), mobile multimedia and video stream media. Both speed and capacity have been the key objectives in transmission. In the meantime, the demand for transmission bandwidth increased at a very quick pace. The coming of 4G and 5G era will provide faster data transmission and higher bit rate and bandwidth. Taking advantages of both optical communication and wireless communication, OFDM Radio over Fiber (OFDM-RoF) system is characterized by its high speed, large capacity and high spectral efficiency. However, up to the present there are some problems to be solved, such as dispersion and nonlinearity effects. In this paper we will study the dispersion and nonlinearity effects and their elimination in OFDM-radio-over-fiber system.

  9. First Magnetic Doppler Images of a roAp star

    Science.gov (United States)

    Lüftinger, T.; Kochukhov, O.; Ryabchikova, T.; Weiss, W. W.; Ilyin, I.

    2007-06-01

    We present the first analysis of the magnetic field geometry and elemental abundance distributions on the surface of a rapidly oscillating Ap (roAp) star, using an elaborate magnetic Doppler Imaging (MDI) code (Piskunov et al. 2002, Kochukhov et al. 2002), inv, which allows to reconstruct simultaneously and consistently the magnetic field geometry and abundance distributions on a stellar surface without any a priori assumptions. We analysed Stokes I and V time series obtained with the SOFIN polarimeter and recovered the magnetic field and surface abundance structures of Fe and Nd (among others). These two elements are found to be anticorrelated.

  10. Transiting exoplanets from the CoRoT space mission

    DEFF Research Database (Denmark)

    Ollivier, M.; Gillon, M.; Santerne, A.

    2012-01-01

    RoT-16b is a 0.535 −0.083/+0.085 MJ, 1.17 −0.14/+0.16 RJ hot Jupiter with a density of 0.44 −0.14/+0.21 g cm-3. Despite its short orbital distance (0.0618 ± 0.0015 AU) and the age of the parent star (6.73 ± 2.8 Gyr), the planet orbit exhibits significantly non-zero eccentricity. This is very uncommon...

  11. Modulation of plasma metabolite biomarkers of MAPK pathway with the MEK inhibitor RO4987655: pharmacodynamic and predictive potential in metastatic melanoma.

    Science.gov (United States)

    Ang, Joo Ern; Pal, Akos; Asad, Yasmin J; Henley, Alan T; Valenti, Melanie; Box, Gary; de Haven Brandon, Alexis; Revell, Victoria; Skene, Debra J; Venturi, Miro; Rueger, Ruediger; Meresse, Valerie; Eccles, Suzanne A; de Bono, Johann S; Kaye, Stanley B; Workman, Paul; Banerji, Udai; Raynaud, Florence I

    2017-06-21

    MAPK pathway activation is frequently observed in human malignancies, including melanoma, and is associated with sensitivity to MEK inhibition and changes in cellular metabolism. Using quantitative mass spectrometry-based metabolomics, we identified in preclinical models 21 plasma metabolites including amino acids, propionylcarnitine, phosphatidylcholines and sphingomyelins that were significantly altered in two B-RAF mutant melanoma xenografts and that were reversed following a single dose of the potent and selective MEK inhibitor RO4987655. Treatment of non-tumour bearing animals and mice bearing the PTEN null U87MG human glioblastoma xenograft elicited plasma changes only in amino acids and propionylcarnitine. In patients with advanced melanoma treated with RO4987655, on-treatment changes of amino acids were observed in patients with disease progression and not in responders. In contrast, changes in phosphatidylcholines and sphingomyelins were observed in responders. Furthermore, pre-treatment levels of 7 lipids identified in the preclinical screen were statistically significantly able to predict objective responses to RO4987655. The RO4987655 treatment-related changes were greater than baseline physiological variability in non-treated individuals. This study provides evidence of a translational exo-metabolomic plasma readout predictive of clinical efficacy together with pharmacodynamic utility following treatment with a signal transduction inhibitor. Copyright ©2017, American Association for Cancer Research.

  12. Scientific heritage of Alexandru Roşca: publications, spider collection, described species

    Directory of Open Access Journals (Sweden)

    Fedoriak, Mariia

    2016-04-01

    During the period 1931–1939, Roşca described 13 spider species. To date, five species names have been synonymised. We propose that six species should be treated as nomina dubia because of their poor descriptions and lack of availability of types and/or other specimens. For two of Roşca’s species, Pardosa roscai (Roewer, 1951 and Tetragnatha reimoseri (Roşca, 1939, data and figures are presented and information on them is updated.

  13. Warm Spitzer Photometry of the Transiting Exoplanets CoRoT-1 and CoRoT-2 at Secondary Eclipse

    CERN Document Server

    Deming, Drake; Agol, Eric; Desert, Jean-Michel; Burrows, Adam; Fortney, Jonathan J; Charbonneau, David; Cowan, Nicolas B; Laughlin, Gregory; Langton, Jonathan; Showman, Adam P; Lewis, Nikole K

    2010-01-01

    We measure secondary eclipses of the hot giant exoplanets CoRoT-1 at 3.6 and 4.5 microns, and CoRoT-2 at 3.6 microns, both using Warm Spitzer. We find that the Warm Spitzer mission is working very well for exoplanet science. For consistency of our analysis we also re-analyze archival cryogenic Spitzer data for secondary eclipses of CoRoT-2 at 4.5 and 8 microns. We compare the total data for both planets, including optical eclipse measurements by the CoRoT mission, and ground-based eclipse measurements at 2 microns, to existing models. Both planets exhibit stronger eclipses at 4.5 than at 3.6 microns, which is often indicative of an atmospheric temperature inversion. The spectrum of CoRoT-1 is best reproduced by a 2460K blackbody, due either to a high altitude layer that strongly absorbs stellar irradiance, or an isothermal region in the planetary atmosphere. The spectrum of CoRoT-2 is unusual because the 8 micron contrast is anomalously low. Non-inverted atmospheres could potentially produce the CoRoT-2 spect...

  14. A search for circumbinary planets in CoRoT eclipsing binary light curves

    Directory of Open Access Journals (Sweden)

    Klagyivik Peter

    2015-01-01

    Full Text Available Several transiting circumbinary planets have been found in data of the Kepler mission [1–5]. Both CoRoT and Kepler have surveyed similar numbers of stars, and the photometric precision of CoRoT is sufficient that it could detect most of the known circumbinary planets; the main draw-back by CoRoT is the much shorter coverage. Still, there is a high chance that some circumbinary planets may be found in its sample of eclipsing binaries (hereafter EBs. Here we report on an ongoing search for circumbinary planets in the full CoRoT data set.

  15. Experimental Study of Advanced Treatment of Coking Wastewater Using MBR-RO Combined Process

    Science.gov (United States)

    Zhang, Lei; Hwang, Jiannyang; Leng, Ting; Xue, Gaifeng; Chang, Hongbing

    A membrane bioreactor-reverse osmosis (MBR-RO) combined process was used for advanced treatment of coking wastewater from secondary biological treatment. MBR and RO units' treatment efficiency for the pollution removal were conducted, and effects of raw water conductivity and trans-membrane pressure on water yield and desalination rate in RO unit were investigated in detail. The experimental results proved that MBR-RO combined process ran steadily with good treatment effect, which could obtain stable effluent water quality and met the requirement of "Design Criterion of the Industrial Circulating Cooling Water Treatment" (GB 50050-2007).

  16. Removal of organic contaminants by RO and NF membranes

    Science.gov (United States)

    Yoon, Yeomin; Lueptow, Richard M.

    2005-01-01

    Rejection characteristics of organic and inorganic compounds were examined for six reverse osmosis (RO) membranes and two nanofiltration (NF) membranes that are commercially available. A batch stirred-cell was employed to determine the membrane flux and the solute rejection for solutions at various concentrations and different pH conditions. The results show that for ionic solutes the degree of separation is influenced mainly by electrostatic exclusion, while for organic solutes the removal depends mainly upon the solute radius and molecular structure. In order to provide a better understanding of rejection mechanisms for the RO and NF membranes, the ratio of solute radius (r(i,s)) to effective membrane pore radius (r(p)) was employed to compare rejections. An empirical relation for the dependence of the rejection of organic compounds on the ratio r(i,s)/r(p) is presented. The rejection for organic compounds is over 75% when r(i,s)/r(p) is greater than 0.8. In addition, the rejection of organic compounds is examined using the extended Nernst-Planck equation coupled with a steric hindrance model. The transport of organic solutes is controlled mainly by diffusion for the compounds that have a high r(i,s)/r(p) ratio, while convection is dominant for compounds that have a small r(i,s)/r(p) ratio. c2005 Elsevier B.V. All rights reserved.

  17. The CoRoT Mission - Status and Preliminary Results

    Science.gov (United States)

    Fridlund, M.

    2007-08-01

    The CoRoT (Convection, Rotation and planetary Transits) space mission is the first dedicated space mission designed to search for exo-planets akin to our own. It is a joint effort by France, Austria Belgium, Brazil, Germany, Spain and the European Space Agency. It is specifically designed to search for exo-planets much smaller than hitherto discovered. It was launched in December 2006 on a mission lasting not less than 3 years. Verification and first operations have proven the mission to superceed all expectations. This is of course most relevant in the fact that planets as small as our own Earth are detectable. In this presentation we describe the experiences of the first 6 mo0nths of the mission, the actual status of the mission, the supporting ground based program, and what we expect in the near future. After giving examples of data relevant to the topic of this session, we turn to describing the expected impact of the results of CoRoT on future endeavours such as KEPLER, Extremely Large Telescopes (ELT's) and ultimately Darwin.

  18. A New Mapping Function Based on GNSS-RO observations

    Science.gov (United States)

    Benedetto, Catia; Rosciano, Elisa; Vespe, Francesco; Vizziello, Giuseppe

    2015-04-01

    The coordinates of a static Global Navigation Satellite System (GNSS) station placed on the ground are estimated together with the delay suffered by the incoming satellite signals through the atmosphere. The tropospheric delay (TD) is shaped as the product of the zenith delay (ZTD) times a mapping function (MF) depending on the sine of elevation angles. In processing chain, ZTD is just estimated together with the coordinates; while the MF is modelled apart, in an independent way, by using atmospheric profiles retrieved with balloon observations ( RAOB) as done for the Niell MF (1996) or provided by climate or Numerical Weather Prediction (NWP) models as in the Vienna MFs. The several space missions devoted to GNSS-RO (e.g. COSMIC-FORMOSAT, METOP, CHAMP, GRACE end others) are providing a huge amount of data which makes worthwhile to be attempted the reconstruction of a new mapping function based on such kind of data. Thus we have built the "Matera" MF ( MTMF) based just on GNSS-RO observations. The new MTMF will be applied to a network of EUREF GNSS stations in the Mediterranean area. Formal errors and repeatability of ZTD and coordinates estimated with the MTMF will be compared with those achieved applying other MF. In validation activities we plan to use the Bernese software.

  19. CoRoT space photometry of seven Cepheids

    CERN Document Server

    Poretti, Ennio; Rainer, Monica; Baglin, Annie; Benko, Jozsef; Debosscher, Jonas; Weiss, Werner W

    2015-01-01

    A few Galactic classical Cepheids were observed in the programmes of space missions as Coriolis, MOST and Kepler. An appealing opportunity was to detect additional nonradial modes, thus opening the possibility to perform asteroseismic studies and making the pulsational content of Galactic Cepheids more similar to that of Magellanic Clouds ones. However, only hints of cycle-to-cycle variations were found, without any strict periodicity. In this context the potential of the CoRoT exoplanetary data base was not fully exploited despite the wide area covered on the Galactic plane. Therefore, we investigated all the candidate Cepheids pointed out by the automatic classification of the CoRoT curves. At the end we could identify seven bona-fide Cepheids. The light curves were investigated to remove some instrumental effects. The frequency analysis was particularly delicate since these small effects can be enhanced by the large amplitude, resulting in the presence of significant, but spurious, peaks in the power spect...

  20. Improved stellar parameters of CoRoT-7

    CERN Document Server

    Bruntt, H; Fridlund, M; Alonso, R; Bouchy, F; Hatzes, A; Mayor, M; Moutou, C; Queloz, D

    2010-01-01

    Accurate parameters of the host stars of exoplanets are important for the interpretation of the new planet systems that continue to emerge. The CoRoT satellite recently discovered a transiting rocky planet with a density similar to the inner planets in our solar system, a so-called Super Earth. This planet is orbiting a relatively faint G9V star called CoRoT-7, and we wish to refine its physical properties, which are important for the interpretation of the properties of the planet system. We used spectra from HARPS@ESO-3.6m and UVES@VLT-8.2m. From the analysis of Fe-1 and Fe-2 lines we determine Teff, log g and microturbulence. We use the Balmer lines to constrain Teff and pressure sensitive Mg-1b and Ca lines to constrain log g. From the analysis we find Teff=5250+-60K, log g = 4.47+-0.05, [M/H]=+0.12+-0.06, and vsini = 1.1 km/s. We compared the L/M ratio with isochrones to constrain the evolutionary status. Using the age estimate of 1.2-2.3 Gyr based on stellar activity, we determine the mass and radius 0.9...

  1. Transiting exoplanets from the CoRoT space mission. XXIII. CoRoT-21b: a doomed large Jupiter around a faint subgiant star

    DEFF Research Database (Denmark)

    Pätzold, M.; Endl, M.; Csizmadia, Sz.

    2012-01-01

    CoRoT-21, a F8IV star of magnitude V = 16 mag, was observed by the space telescope CoRoT during the Long Run 01 (LRa01) in the first winter field (constellation Monoceros) from October 2007 to March 2008. Transits were discovered during the light curve processing. Radial velocity follow-up observ......CoRoT-21, a F8IV star of magnitude V = 16 mag, was observed by the space telescope CoRoT during the Long Run 01 (LRa01) in the first winter field (constellation Monoceros) from October 2007 to March 2008. Transits were discovered during the light curve processing. Radial velocity follow...

  2. Dynamic analysis of multibodies system with a floating base for rolling of ro-ro ship caused by wave and slip of heavy load

    Institute of Scientific and Technical Information of China (English)

    SHEN Qing; LI Yue; CHEN Xu-jun

    2003-01-01

    Common effect of wave and slip of internal heavy load will make rolling of the roll-on ship serious. This is one of the important reasons for overturn of ro-ro ships. The multibodies System with a floating base is composed of ro-ro ship and slipping heavy load. This paper takes the rolling angle of the ship and the transverse displacement of the heavy load on desk as two freedoms. Making use of analysis of apparent gravitation and apparent buoyancy, the wave rolling moment is derived. By use of dynamic method of multibodies system with a floating base, dynamic equations of the system are established. Taking a certain channel ferry as an example, a set of numerical calculation have been carried out for rolling response of the ship and displacement response of the slipping heavy load under common effect of synchro-slipping heavy loads and wave.

  3. Using Green Supply Chain Management to Meet Challenge of RoHS%以绿色供应链管理应对RoHS挑战

    Institute of Scientific and Technical Information of China (English)

    张军; 熊振华; 萧瑞化

    2006-01-01

    欧盟的电子电器产品有害物质限用指令(RoHS)于2006年7月1日起开始生效这项指令管辖范围遍及整个电子电器产业链,不仅影响整机制造商,还将涉及相关零部件、塑料等包装材料企业.因此进行绿色供应链管理是应对RoHS指令的有效措施.本文结合RoHS评价要素的展开,介绍企业如何应用AHP方法评价优选供应商,满足RoHS指令要求,从而提高产品在国际市场的竞争力.

  4. 改进的可配置RO PUF及其实现%Improvement and implementation of configurable RO PU F

    Institute of Scientific and Technical Information of China (English)

    丁浩; 王建业

    2015-01-01

    To add the number of ID extracted from physical characters of FPGA chips and play a better role in device authentica‐tion ,Maiti’s configurable RO PUF (ring‐oscillator‐based physical unclonable function) was optimized by adding the tunable de‐lay unit to the basic RO PUF .Improved configurable RO PUF was implemented on FPGA development platform .Results show that the improved configurable RO PUF can increase the amount of ID significantly with higher utility ratio of LAB (logic array block) resources in FPGA ,and improve the intra‐chip reliability and inter‐chip variation of ID .Experiments also verify the use‐fulness and feasibility of the improved configurable RO PUF .%为增加从FPGA芯片的物理特性中提取出的ID数量,更好地用于设备认证等用途,对M aiti的“可配置基于环形振荡器的物理不可克隆功能”(ring‐oscillator‐based physical unclonable function ,RO PUF)进行改进。在基本RO PUF的基础上,增加“可调延时单元”,在FPGA开发平台上进行实验。实验结果表明,改进后的RO PU F可以显著增加提取出的ID数量,提高片内逻辑阵列块(logic array block , LAB)的资源利用率,提高ID的“片内稳定性”和“片间差异性”,验证了其有效性和可行性。

  5. Dalla pizza alla cura dell'uomo: le abilità di RoDyMan

    Directory of Open Access Journals (Sweden)

    Nunzia Bonifati

    2014-12-01

    Full Text Available RoDyMan, acronym for Robotic Dynamic Manipulation, is a research project funded by the European Research Council to the CREATE Consortium and carried out at PRISMA Lab in the Department of Electrical Engineering and Information Technology of the University of Naples Federico II. The goal is the development of a service robot able to manipulate elastic and soft objects, which change continuously density and shape. These robots will be used not only in manufacturing but also as an aid to elderly or disabled people, for medical and surgical use, and in other manual activities. Preparing a pizza involves an extraordinary level of manual dexterity: for this reason a pizzaiolo robot has been conceived. It is also a tribute to Naples, at the forefront of technology, robotics and automation, but especially of culture and gastronomy, of which pizza is a symbol and tradition. Creating a robot able to manipulate objects like humans is one of the most sought and difficult challenges of robotics. It means to replicate skills that are the result of human biological and cultural evolution. This goal is arduous, mainly for two issues. First, we do not have a total knowledge of human nature, but this is the condition to be able to replicate the human functions in a machine. Second, there are many technical limits to implement a bio‐inspired robot, not the least those making it user‐friendly and aesthetically appreciated.

  6. The anxiogenic action of RO 5-4864 in the social interaction test: effect of chlordiazepoxide, RO 15-1788 and CGS 8216.

    Science.gov (United States)

    File, S E; Pellow, S

    1985-01-01

    RO 5-4864 (20 mg/kg), a benzodiazepine with high affinity for peripheral-type benzodiazepine binding sites in rat kidney and brain, but not for the "classical" CNS sites, reduced the time spent by pairs of rats in active social interaction, without reducing locomotor activity, possibly reflecting an anxiogenic action. This anxiogenic effect was not reversed by chlordiazepoxide (5 or 10 mg/kg) given acutely, but was reversed by chlordiazepoxide (5 mg/kg) given for 5 days prior to testing. RO 15-1788 (10 mg/kg), a drug that antagonises several effects of benzodiazepines but has little affinity for peripheral-type sites, had no action on the reduction in social interaction induced by RO 5-4864. However, CGS 8216 (10 mg/kg) which also antagonises the effects of benzodiazepines and has little affinity for RO 5-4864 recognition sites, significantly enhanced the reduction in social interaction caused by RO 5-4864, and the combination produced a significant decrease in locomotor activity. These results are discussed in terms of possible sites of action of RO 5-4864 on the GABA-benzodiazepine receptor complex.

  7. Pre-discovery observations of CoRoT-1b and CoRoT-2b with the BEST survey

    CERN Document Server

    Rauer, H; Kabath, P; Hedelt, P; Boër, M; Carone, L; Csizmadia, Sz; Eigmueller, P; Paris, P v; Renner, S; Tournois, G; Titz, R; Voss, H

    2009-01-01

    The BEST wide-angle telescope installed at the Observatoire de Haute-Provence and operated in remote control from Berlin by the Institut fuer Planetenforschung, DLR, has observed the CoRoT target fields prior to the mission. The resulting archive of stellar photometric lightcurves is used to search for deep transit events announced during CoRoT's alarm-mode to aid in fast photometric confirmation of these events. The "initial run" field of CoRoT (IRa01) has been observed with BEST in November and December 2006 for 12 nights. The first "long run" field (LRc01) was observed from June to September 2005 for 35 nights. After standard CCD data reduction, aperture photometry has been performed using the ISIS image subtraction method. About 30,000 lightcurves were obtained in each field. Transits of the first detected planets by the CoRoT mission, CoRoT-1b and CoRoT-2b, were found in archived data of the BEST survey and their lightcurves are presented here. Such detections provide useful information at the early stag...

  8. Alar Pääro La Galerie Passage'is / Viivi Põlma

    Index Scriptorium Estoniae

    Põlma, Viivi

    2000-01-01

    Iseõppijast maalikunstniku Alar Pääro esimene personaalnäitus "On aeg" 20. I-20. II La Galerie Passage'is. 1993. aastast on A. Pääro töötanud vabakutselise kunstnikuna, mida on talle võimaldanud metseen Kalev Klais

  9. The Ro 15-1788 cue: Evidence for benzodiazepine agonist and inverse agonist properties

    NARCIS (Netherlands)

    Vry, J. De; Slangen, J.L.

    1985-01-01

    Rats discriminating Ro 15–1788 (10 mg/kg, i.p.) from vehicle completely generalized this cue to typical benzodizepines, and partially generalized it to barbiturates, pentylenetetrazol, CGS 8216, β-CCM and PK 8165. CL 218 872, Ro 5–4864, phenytoine, progabide, propranolol, yohimbine and various CNS s

  10. Planetary transit candidates in CoRoT LRa01 field

    DEFF Research Database (Denmark)

    Carone, L.; Gandolfi, D.; Cabrera, J.;

    2012-01-01

    We present the list of planetary transit candidates from the CoRoT LRa01 star field in the Monoceros constellation toward the Galactic anti-center direction. The CoRoT observations of LRa01 lasted from 24 October 2007 to 3 March 2008. We acquired and analyzed 7470 chromatic and 3938 monochromatic...

  11. Présentation du numéro

    Directory of Open Access Journals (Sweden)

    Shirley Carter-Thomas

    2011-07-01

    Full Text Available Ce numéro rassemble une sélection d’articles présentés lors de la première conférence LPTS (Linguistic and Psycholinguistic approaches to Text Structuring qui s’est tenue à l’École normale supérieure (Ulm, Paris du 21 au 23 septembre 2009, conférence organisée en clôture du projet ANR Spatial Framing Adverbials. Nous avons amené au cœur des thèmes de la conférence une série de questions sur les marqueurs de structuration du discours (adverbiau...

  12. Introduction à Varia, le numéro permanent

    Directory of Open Access Journals (Sweden)

    Virginie Amilien

    2008-12-01

    Full Text Available Depuis la publication du premier numéro en 2001 consacré aux ‘traditions et identités alimentaires locales’, la revue Anthropology of Food a fait du chemin. Onze numéros ont aujourd’hui été publiés en ligne, de nouveaux thèmes ont ouvert la voie à un certain nombre de recherches et de reflexions. La contribution de nos collègues de nombreux pays s’est élargie et la mission que nous nous étions confiée au sein de l’équipe éditoriale commence à porter ses fruits. La revue reçoit aujourd’hui un ...

  13. TU-CD-BRD-00: Incident Learning / RO-ILS

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2015-06-15

    It has long been standard practice in radiation oncology to report internally when a patient’s treatment has not gone as planned and to report events to regulatory agencies when legally required. Most potential errors are caught early and never affect the patient. Quality assurance steps routinely prevent errors from reaching the patient, and these “near misses” are much more frequent than treatment errors. A growing number of radiation oncology facilities have implemented incident learning systems to report and analyze both errors and near misses. Using the term “incident learning” instead of “event reporting” emphasizes the need to use these experiences to change the practice and make future errors less likely and promote an educational, non-punitive environment. There are challenges in making such a system practical and effective. Speakers from institutions of different sizes and practice environments will share their experiences on how to make such a system work and what benefits their clinics have accrued. Questions that will be addressed include: How to create a system that is easy for front line staff to access How to motivate staff to report How to promote the system as positive and educational and not punitive or demeaning How to organize the team for reviewing and responding to reports How to prioritize which reports to discuss in depth How not to dismiss the rest How to identify underlying causes How to design corrective actions and implement change How to develop useful statistics and analysis tools How to coordinate a departmental system with a larger risk management system How to do this without a dedicated quality manager Some speakers’ experience is with in-house systems and some will share experience with the AAPM/ASTRO national Radiation Oncology Incident Learning System (RO-ILS). Reports intended to be of value nationally need to be comprehensible to outsiders; examples of useful reports will be shown. There will be ample time set

  14. Revue de presse du numéro 44

    OpenAIRE

    2006-01-01

    Liens-socio.org, juillet 2005"Vous avez tous entendus parler de la vieille querelle entre Emile Durkheim et Gabriel Tarde et vous pensiez tous que ce brave Emile avait définitivement gagné? Détrompez-vous! Ce numéro de la revue Terrain s'efforce de nous démontrer le contraire et de façon convaincante, il faut bien l'avouer! En 1890 Tarde publie Les lois de l'imitation, et s'attire les foudres de Durkheim pour qui les phénomènes sociaux sont forcément coercitifs. Or Tarde cherche à montrer le ...

  15. RO brine treatment and recovery by biological activated carbon and capacitive deionization process.

    Science.gov (United States)

    Tao, Guihe; Viswanath, Bala; Kekre, Kiran; Lee, Lai Yoke; Ng, How Yong; Ong, Say Leong; Seah, Harry

    2011-01-01

    The generation of brine solutions from dense membrane (reverse osmosis, RO or nanofiltration, NF) water reclamation systems has been increasing worldwide, and the lack of cost effective disposal options is becoming a critical water resources management issue. In Singapore, NEWater is the product of a multiple barrier water reclamation process from secondary treated domestic effluent using MF/UF-RO and UV technologies. The RO brine (concentrates) accounts for more than 20% of the total flow treated. To increase the water recovery and treat the RO brine, a CDI based process with BAC as pretreatment was tested. The results show that ion concentrations in CDI product were low except SiO2 when compared with RO feed water. CDI product was passed through a RO and the RO permeate was of better quality including low SiO2 as compared to NEWater quality. It could be beneficial to use a dedicated RO operated at optimum conditions with better performance to recover the water. BAC was able to achieve 15-27% TOC removal of RO brine. CDI had been tested at a water recovery ranging from 71.6 to 92.3%. CDI based RO brine treatment could improve overall water recovery of NEWater production over 90%. It was found that calcium phosphate scaling and organic fouling was the major cause of CDI pressure increase. Ozone disinfection and sodium bisulfite dosing were able to reduce CDI fouling rate. For sustainable operation of CDI organic fouling control and effective organic fouling cleaning should be further studied.

  16. Ameerika, Euroopa ja ÜRO võistlevad Iraagi humanitaarkriisi lahendamise pärast / Geraldine Chatelard

    Index Scriptorium Estoniae

    Chatelard, Geraldine

    2003-01-01

    ÜRO Genfi põgenikeagentuuri teaduri sõnul ei jõua USA ÜRO tegevust, Euroopa humanitaarorganisatsioone ja Iraagi kohalikke institutsioone umbusaldades Iraagi humanitaarkriisi lahendamises kuigi kaugele

  17. VizieR Online Data Catalog: CoRoT observation log (N2-4.4) (CoRoT 2016)

    Science.gov (United States)

    COROT Team

    CoRoT, a space astronomy mission, has measured photometric micro-variability of stars from minutes to months (up to 150 days) with a high duty cycle (more than 90%). The mission was led by CNES in association with four French laboratories and 7 participating countries and agencies (Austria, Belgium, Brazil, Germany, Spain, and the ESA Science Programme). The satellite was composed of a PROTEUS platform (the 3rd in the series) and a unique instrument: a stellar rapid photometer. It was launched on December 27th 2006 by a Soyuz Rocket, from Baikonour. The mission has lasted almost 6 years (the nominal 3-year duration and a 3-year extension) and has observed more than 160 000 stars. It stopped sending data on November 2nd 2012. Two regions of the sky were accessible for long period of time: circles of 10 degrees centered on the equator around alpha=06:50 and alpha=18:50. They were called the CoRoT eyes: the "anticenter" and the "center eye" (as they are approximately in these directions). Each pointing covers 1.4x2.8 square degrees within one of those CoRoT eyes. The original scientific objectives were focussed on the study of stellar pulsations (asteroseismology) to probe the internal structure of stars, and the detection of small exoplanets through their "transit" in front of their host star, and the measurement of their size. This lead to introduce two modes of observations, working simultaneously: - The "bright star" mode dedicated to very precise seismology of a small sample of bright and closeby stars - The "faint star" mode, observing a very large number of stars at the same time, to detect transits, which are rare events, as they imply the alignment of the star, the planet and the observer. The large amount of data gathered in this mode turned out to be extremely fruitful for many topics of stellar physics. Beyond these two initial objectives, CoRoT data revealed stellar variability associated with various other phenomena: granulation, rotational modulation by

  18. Mode of action of the dual-action cephalosporin Ro 23-9424.

    Science.gov (United States)

    Georgopapadakou, N H; Bertasso, A; Chan, K K; Chapman, J S; Cleeland, R; Cummings, L M; Dix, B A; Keith, D D

    1989-07-01

    Ro 23-9424 is a broad-spectrum antibacterial agent composed of a cephalosporin and a quinolone moiety. Its biological properties were compared with those of its two components and structurally related cephalosporins and quinolones. Like ceftriaxone and cefotaxime but unlike its decomposition product, desacetyl cefotaxime, Ro 23-9424 bound at less than or equal to 2 micrograms/ml to the essential penicillin-binding proteins 1b and 3 of Escherichia coli and 1, 2, and 3 of Staphylococcus aureus. In E. coli, Ro 23-9424 produced filaments exclusively and decreased cell growth; cefotaxime produced both filaments and lysis. Like its decomposition product fleroxacin but unlike quinolone esters, Ro 23-9424 also inhibited replicative DNA biosynthesis in E. coli. In an E. coli strain lacking OmpF, growth continued after addition of Ro 23-9424, decreased after addition of cefotaxime, and stopped immediately after addition of fleroxacin. The results, together with the chemical stability of Ro 23-9424 (half-life, approximately 3 h at pH 7.4 and 37 degrees C), suggest that in E. coli the compound acts initially as a cephalosporin with intrinsic activity comparable to that of cefotaxime but with poorer penetration. Subsequent to the decomposition of Ro 23-9424 to fleroxacin and desacetyl cefotaxime, quinolone activity appears. The in vitro antibacterial activity reflects both mechanisms of action.

  19. Transiting exoplanets from the CoRoT space mission XXV. CoRoT-27b: a massive and dense planet on a short-period orbit

    CERN Document Server

    Parviainen, H; Deleuil, M; Moutou, C; Deeg, H J; Ferraz-Mello, S; Samuel, B; Csizmadia, Sz; Pasternacki, T; Wuchterl, G; Havel, M; Fridlund, M; Agnus, R; Tingley, B; Aigrain, S; Almenara, J M; Alonso, R; Baglin, A; Barros, S; Bordé, A S P; Bouchy, F; Cabrera, J; Díaz, R; Dvorak, R; Erikson, A; Guillot, T; Hatzes, A; Hébrard, G; Mazeh, T; Montagnier, G; Ofir, A; Ollivier, M; Pätzold, M; Rauer, H; Rouan, D; Santerne, A; Schneider, J

    2014-01-01

    We report the discovery of a massive and dense transiting planet CoRoT-27b on a 3.58 day orbit around a 4.2 Gyr-old G2~star. The planet candidate was identified from the CoRoT photometry, and was confirmed as a planet with ground-based spectroscopy. The confirmation of the planet candidate is based on radial velocity observations combined with imaging to rule out blends. The characterisation of the planet and its host star is carried out using a Bayesian approach where all the data (CoRoT photometry, radial velocities, and spectroscopic characterisation of the star) are used jointly. The Bayesian analysis includes a study whether the assumption of white normally distributed noise holds for the CoRoT photometry, and whether the use of a non-normal noise distribution offers advantages in parameter estimation and model selection. CoRoT-27b has a mass of $10.39 \\pm 0.55$ $\\mathrm{M}_{\\rm Jup}$, a radius of $1.01 \\pm 0.04$ $\\mathrm{R}_{\\rm Jup}$, a mean density of $12.6_{-1.67}^{+1.92}$ $\\mathrm{g\\,cm^{-3}}$, and ...

  20. Transiting exoplanets from the CoRoT space mission: VII. The "hot-Jupiter"-type planet CoRoT-5b

    CERN Document Server

    Rauer, H; Csizmadia, Sz; Deleuil, M; Alonso, R; Aigrain, S; Almenara, J M; Auvergne, M; Baglin, A; Barge, P; Borde, P; Bouchy, F; Bruntt, H; Cabrera, J; Carone, L; Carpano, S; De la Reza, R; Deeg, H J; Dvorak, R; Erikson, A; Fridlund, M; Gandolfi, D; Gillon, M; Guillot, T; Günther, E; Hatzes, A; Hébrard, G; Kabath, P; Jorda, L; Lammer, H; Léger, A; Llebaria, A; Magain, P; Mazeh, T; Moutou, C; Ollivier, M; Paetzold, M; Pont, F; Rabus, M; Renner, S; Rouan, D; Shporer, A; Samuel, B; Schneider, J; Triaud, A H M J; Wuchterl, G

    2009-01-01

    Aims. The CoRoT space mission continues to photometrically monitor about 12 000 stars in its field-of-view for a series of target fields to search for transiting extrasolar planets ever since 2007. Deep transit signals can be detected quickly in the "alarm-mode" in parallel to the ongoing target field monitoring. CoRoT's first planets have been detected in this mode. Methods. The CoRoT raw lightcurves are filtered for orbital residuals, outliers, and low-frequency stellar signals. The phase folded lightcurve is used to fit the transit signal and derive the main planetary parameters. Radial velocity follow-up observations were initiated to secure the detection and to derive the planet mass. Results. We report the detection of CoRoT-5b, detected during observations of the LRa01 field, the first long-duration field in the galactic anticenter direction. CoRoT-5b is a "hot Jupiter-type" planet with a radius of 1.388(+0.046, -0.047) R_Jup, a mass of 0.467(+0.047, -0.024) M_Jup, and therefore, a mean density of 0.21...

  1. Gibberellins regulate the transcription of the continuous flowering regulator, RoKSN, a rose TFL1 homologue.

    Science.gov (United States)

    Randoux, Marie; Jeauffre, Julien; Thouroude, Tatiana; Vasseur, François; Hamama, Latifa; Juchaux, Marjorie; Sakr, Soulaiman; Foucher, Fabrice

    2012-11-01

    The role of gibberellins (GAs) during floral induction has been widely studied in the annual plant Arabidopsis thaliana. Less is known about this control in perennials. It is thought that GA is a major regulator of flowering in rose. In spring, low GA content may be necessary for floral initiation. GA inhibited flowering in once-flowering roses, whereas GA did not block blooming in continuous-flowering roses. Recently, RoKSN, a homologue of TFL1, was shown to control continuous flowering. The loss of RoKSN function led to continuous flowering behaviour. The objective of this study was to understand the molecular control of flowering by GA and the involvement of RoKSN in this inhibition. In once-flowering rose, the exogenous application of GA(3) in spring inhibited floral initiation. Application of GA(3) during a short period of 1 month, corresponding to the floral transition, was sufficient to inhibit flowering. At the molecular level, RoKSN transcripts were accumulated after GA(3) treatment. In spring, this accumulation is correlated with floral inhibition. Other floral genes such as RoFT, RoSOC1, and RoAP1 were repressed in a RoKSN-dependent pathway, whereas RoLFY and RoFD repression was RoKSN independent. The RoKSN promoter contained GA-responsive cis-elements, whose deletion suppressed the response to GA in a heterologous system. In summer, once-flowering roses did not flower even after exogenous application of a GA synthesis inhibitor that failed to repress RoKSN. A model is presented for the GA inhibition of flowering in spring mediated by the induction of RoKSN. In summer, factors other than GA may control RoKSN.

  2. Effect of Watertight Subdivision on Subdivision Index for Medium Size Ro–Ro Passenger Ferries

    Directory of Open Access Journals (Sweden)

    M. Pawlowski

    2017-09-01

    Full Text Available Ro-pax vessels should fulfil the requirements of the current harmonised SOLAS Convention. The study analyses the effect of various ro-pax vessel subdivision arrangements on the subdivision index. A Polish ferry was chosen as a generic ship to perform the study. For illustration of damage survivability, the attained subdivision index A was calculated for a number of modified configurations. The arrangements included single and double sides above and below the car deck, with and without a double buoyant car deck. The conclusions of the study can be used in the design of new ro-pax vessels.

  3. Exploration of the brown dwarf regime around solar-like stars by CoRoT

    CERN Document Server

    Csizmadia, Szilárd

    2016-01-01

    Aims. A summary of the CoRoT brown dwarf investigations are presented. Methods. Transiting brown dwarfs around solar like stars were studied by using the photometric time-series of CoRoT, and ground based radial velocity measurements. Results. CoRoT detected three transiting brown dwarfs around F and G dwarf stars. The occurence rate of brown dwarfs was found to be 0.20 +/- 0.15% around solar-like stars which is compatible with the value obtained by Kepler-data.

  4. Complete atrioventricular block in adult Sjögren's syndrome with anti-Ro autoantibody.

    Science.gov (United States)

    Sung, Myung Jun; Park, Sung-Hoon; Kim, Seong-Kyu; Lee, Young-Soo; Park, Chul-Yeon; Choe, Jung-Yoon

    2011-06-01

    Anti-Ro autoantibody is associated with Sjögren's syndrome (SS), systemic lupus erythematosus (SLE), and neonatal lupus syndrome (i.e., congenital complete heart block in newborns). Generally, the adult atrioventricular (AV) node is believed to be relatively resistant to the scarring effects of anti-Ro/anti-La autoantibodies. However, there have been some reports of adult complete AV block in SS and SLE patients. Here, we report a case of complete heart block in primary SS with anti-Ro autoantibodies, with no other risk factor for the development of heart block, and review their etiological association.

  5. Ilves osaleb ÜRO Peaassamblee 62. istungjärgul

    Index Scriptorium Estoniae

    2007-01-01

    President Toomas Hendrik Ilves osaleb New Yorgis ÜRO peaassamblee 62. istungjärgu töös. Eesti riigipea osaleb ka ÜRO korraldatud kliimamuutuste konverentsil, kohtub ÜRO peasekretäri ja Makedoonia, Slovakkia ning Bosnia ja Hertsegoviina presidendiga, samuti filantroop George Sorosega ning osaleb Baltimaade riigipeade kohtumisel. T.H. Ilves külastab ka Columbia Ülikooli ning osaleb New Yorgi Eesti haridusseltsi korraldatud vastuvõtul New Yorgi Eesti Majas. Vabariigi President töövisiidil Ameerika Ühendriikides 20.-26.09.2007

  6. Pulsation models for the roAp star HD 134214

    CERN Document Server

    Saio, H; Weiss, W W; Matthews, J M; Ryabchikova, T

    2011-01-01

    Precise time-series photometry with the MOST satellite has led to identification of 10 pulsation frequencies in the rapidly oscillating Ap (roAp) star HD 134214. We have fitted the observed frequencies with theoretical frequencies of axisymmetric modes in a grid of stellar models with dipole magnetic fields. We find that, among models with a standard composition of $(X,Z) = (0.70,0.02)$ and with suppressed convection, eigenfrequencies of a $1.65\\,{\\rm M}_\\odot$ model with $\\log T_{\\rm eff} = 3.858$ and a polar magnetic field strength of 4.1kG agree best with the observed frequencies. We identify the observed pulsation frequency with the largest amplitude as a deformed dipole ($\\ell = 1$) mode, and the four next-largest-amplitude frequencies as deformed $\\ell = 2$ modes. These modes have a radial quasi-node in the outermost atmospheric layers ($\\tau \\sim 10^{-3}$). Although the model frequencies agree roughly with observed ones, they are all above the acoustic cut-off frequency for the model atmosphere and hen...

  7. Transiting exoplanets from the CoRoT space mission XVII. The hot Jupiter CoRoT-17b: a very old planet

    CERN Document Server

    Csizmadia, Sz; Deleuil, M; Cabrera, J; Fridlund, M; Gandolfi, D; Aigrain, S; Alonso, R; Almenara, J M; Auvergne, M; Baglin, A; Barge, P; Bonomo, A S; Borde, P; Bouchy, F; Bruntt, H; Carone, L; Carpano, S; Cavarroc, C; Cochran, W; Deeg, H J; Diaz, R F; Dvorak, R; Endl, M; Erikson, A; Ferraz-Mello, S; Fruth, Th; Gazzano, J C; Gillon, M; Guenther, E W; Guillot, T; Hatzes, A; Havel, M; Hebrard, G; Jehin, E; Jorda, L; Leger, A; Llebaria, A; Lammer, H; Lovis, C; MacQueen, P J; Mazeh, T; Ollivier, M; Paetzold, M; Queloz, D; Rauer, H; Rouan, D; Santerne, A; Schneider, J; Tingley, B; Titz-Weider, R; Wuchterl, G

    2011-01-01

    We report on the discovery of a hot Jupiter-type exoplanet, CoRoT-17b, detected by the CoRoT satellite. It has a mass of $2.43\\pm0.30$\\Mjup and a radius of $1.02\\pm0.07$\\Rjup, while its mean density is $2.82\\pm0.38$ g/cm$^3$. CoRoT-17b is in a circular orbit with a period of $3.7681\\pm0.0003$ days. The host star is an old ($10.7\\pm1.0$ Gyr) main-sequence star, which makes it an intriguing object for planetary evolution studies. The planet's internal composition is not well constrained and can range from pure H/He to one that can contain $\\sim$380 earth masses of heavier elements.

  8. 滚装船减摇装置设计及仿真分析%Design and Analysis of Anti-Rolling Device for Ro-Ro Ships

    Institute of Scientific and Technical Information of China (English)

    高兆栋; 马汝建; 任升峰

    2011-01-01

    设计一种滚装船机械式减摇装置,该装置利用运载的车辆和货物作为减摇质量体,在不减小船舶承载能力的前提下,可以有效提高系统的质量比,得到较好的减摇效果.详细阐述了各部分的结构和功能,并通过分析减摇装置的质量比、阻尼比和固有频率比对减摇指数的影响规律,得出各参数的最佳选择范围.以宝华号滚装船的参数为样本,确定了弹簧参数和阻尼器参数.仿真结果表明,减摇装置具有较好的减摇效果.%A mechanical type anti-rolling device for ro-ro ships was designed based on the principle of extended tuned mass damp er. Compared with the existing anti-rolling devices, the device can be used not only for newly-built ships, but also for the remodel of used ships since it has the advantages of lower modified cost and easy installation. The cargoes on board are used as tuned masses for the roll ing control of the ro-ro ships in the design. The structures and functions of each part of the device are described in detail. The effects of structural parameters,such as mass ratio,damping ratio and frequency ratio,on the anti-rolling index are analyzed and an optimal range of each parameter is obtained. Taking the Baohua ro-ro ship as an example,the parameters of springs and dampers are determined.

  9. Development Strategy for Xiamen Automobile Ro-roWharf%厦门汽车滚装码头发展对策

    Institute of Scientific and Technical Information of China (English)

    俞炳熙

    2011-01-01

    运用SWOT分析法研究厦门汽车滚装码头的内部优势、劣势、外部机遇、挑战,并分析了外国先进汽车滚装码头的发展现状,最后对厦门汽车滚装码头发展提出对策及建议.%The paper studies the internal strengths, weaknesses and external opportunities and challenges of Xiamen automobile ro-ro wharf and gives countermeasures and suggestions for its healthy development.

  10. Transiting exoplanets from the CoRoT space mission III. The spectroscopic transit of CoRoT-Exo-2b with SOPHIE and HARPS

    CERN Document Server

    Bouchy, F; Deleuil, M; Loeillet, B; Hatzes, A P; Aigrain, S; Alonso, R; Auvergne, M; Baglin, A; Barge, P; Benz, W; Bordé, P; Deeg, H J; De la Reza, R; Dvorak, R; Erikson, A; Fridlund, M; Gondoin, P; Guillot, T; Hébrard, G; Jorda, L; Lammer, H; Léger, A; Llebaria, A; Magain, P; Mayor, M; Moutou, C; Ollivier, M; Pätzold, M; Pepe, F; Pont, F; Rauer, H; Rouan, D; Schneider, J; Triaud, A H M J; Udry, S; Wuchterl, G

    2008-01-01

    We report on the spectroscopic transit of the massive hot-Jupiter CoRoT-Exo-2b observed with the high-precision spectrographs SOPHIE and HARPS. By modeling the radial velocity anomaly occurring during the transit due to the Rossiter-McLaughlin (RM) effect, we determine the sky-projected angle between the stellar spin and the planetary orbital axis to be close to zero lambda=7.2+-4.5 deg, and we secure the planetary nature of CoRoT-Exo-2b. We discuss the influence of the stellar activity on the RM modeling. Spectral analysis of the parent star from HARPS spectra are presented.

  11. Piinatud birmalased ootavad ÜRO seni jõuetut abikätt / Karin Dean

    Index Scriptorium Estoniae

    Dean, Karin

    2007-01-01

    Buda munkade eestvedmisel toimunud massimeeleavalduste mahasurumisest Birmas. ÜRO erisaadiku Ibrahim Gambari kohtumisest nii Birma kindralite kui ka opositsiooniliidri Aung San Suu Kyiga oodatakse tulemusi ja sanktsioone Lisa: Sõjaväe haardes riik

  12. Exoplanets versus brown dwarfs: the CoRoT view and the future

    CERN Document Server

    Schneider, Jean

    2016-01-01

    CoRoT has detected by transit several tens of objects whose radii run from 1.67 Earth radius. Their mass run from less than 5.7 Earth mass (CoRoT-24 b, Alonso et al. 2014) to 63 Jupiter mass (CoRoT-15 b, Bouchy et al. 2011). One could be tempted to think that more massive the object is, the larger it is in size and that there is some limit in mass and/or radius beyond which objects are not planets but very low mass stars below the 80 Jupiter mass limit to trigger nuclear fusion (namely "brown dwarfs" ). CoRoT findings contribute to the planet versus brown dwarf debate since there is no clear mass-radius relation.

  13. Piinatud birmalased ootavad ÜRO seni jõuetut abikätt / Karin Dean

    Index Scriptorium Estoniae

    Dean, Karin

    2007-01-01

    Buda munkade eestvedmisel toimunud massimeeleavalduste mahasurumisest Birmas. ÜRO erisaadiku Ibrahim Gambari kohtumisest nii Birma kindralite kui ka opositsiooniliidri Aung San Suu Kyiga oodatakse tulemusi ja sanktsioone Lisa: Sõjaväe haardes riik

  14. 研华自动化适应RoHS的UNO系列产品上市

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    研华自动化近期重新发布了适应RoHS的UNO系列热卖品,包括:UNO-2170,UNO-2171,UNO-3072L和UNO-3074。这些UNO产品保持了之前的优良特性,同时包含百分百的适应RoHS,现已在订购中。适应RoHS的UNO系列产品不仅使前期渠道合作者能保持原有的环境,同时适应了欧洲处理有害废物的政策。RoHS(针对有害物质在电气、电子设备中的使用)要求组成产品的元件含有最小的铅、

  15. 骨干网络中RoQ攻击的监测、定位和识别%MIL-RoQ:Monitoring,Identifying and Locating the RoQ Attack in Backbone Ne two rk

    Institute of Scientific and Technical Information of China (English)

    文坤; 杨家海; 程凤娟; 尹辉; 王健峰

    2015-01-01

    降质(reduction of quality ,RoQ)攻击是一种非典型拒绝服务攻击,它利用TCP自适应机制的安全漏洞能够显著降低或抑制TCP服务质量,且具有很强的隐蔽性。现有的研究集中在针对单条网络链路上的攻击和检测。但是,Ro Q攻击的对象并不局限于此,它既可以对单条链路发动攻击,也可以有选择的对多条链路(甚至整个网络)发起攻击,造成更大的危害,所以需要有一种能够从网络全局角度分析和识别的方法。为此,提出了一种基于骨干网络流量分析的异常监测、定位和识别的方法M IL‐Ro Q (monitoring ,identifying and locating the RoQ attack in backbone network )。主要使用主成分分析(principal component analysis ,PCA )和频谱分析(spectrum analysis)技术对骨干流量进行流量建模分析,从全局角度监测网络流量变化情况,能够同时分析和判断多条链路的异常情况,并能准确识别出Ro Q攻击。使用了CERNET骨干网络数据进行实验分析,结果表明该方法能够有效地定位和识别RoQ 攻击;同时,攻击识别时只需要使用局部的流量数据,因而能显著降低计算量和复杂度。%Reduction of quality (RoQ) attack is an atypical denial of service (DoS) attack ,which exploits the vulnerability of TCP's adaptive behavior that can seriously reduce or inhibit the throughput of TCP flows .While most of the defensive methods are studied on the single network access link (router) ,the RoQ attack can not only launch on the single network link ,but also attack towards several links or even entire network ,which causes more severe consequences .In order to obtain a global perspective from the network and identify the attack ,in this paper we propose a traffic anomaly analysis method to monitor ,identify and locate the RoQ attack in backbone network on the basis of principal component analysis (PCA ) and spectrum analysis

  16. ÜRO ei kohusta Eestit 9. maid tähistama / Neeme Raud

    Index Scriptorium Estoniae

    Raud, Neeme, 1969-

    2004-01-01

    Venemaa eestvõttel võttis ÜRO vastu resolutsiooni, milles kuulutatakse 9. mai Teise maailmasõja lõpu tähistamise päevaks. ÜRO peaassambleel EL-i nimel kõnelnud Hollandi suursaadik märkis, et osa alliansi riikide jaoks ei tähista 8. ja 9. mai 1945 võitu

  17. CoRoBa, a Multi Mobile Robot Control and Simulation Framework

    Directory of Open Access Journals (Sweden)

    Eric Colon

    2008-11-01

    Full Text Available This paper describes on-going development of a multi robot control framework named CoRoBa. CoRoBa is theoretically founded by reifying Real Time Design Patterns. It uses CORBA as its communication Middleware and consequently benefits from the interoperability of this standard. A multi-robot 3D simulator written in Java3D integrates seamlessly with this framework. Several demonstration applications have been developed to validate the design and implementation options.

  18. RO 15-1788 antagonises the central effects of diazepam in man without altering diazepam bioavailability.

    OpenAIRE

    1982-01-01

    1 In a double-blind, placebo controlled study, the efficacy of Ro 15-1788, a new benzodiazepine antagonist, in blocking the cognitive, psychomotor and subjective effects of diazepam, was investigated in a group of six healthy male volunteers. 2 The central effects of orally administered diazepam (40 mg) were most pronounced 1 h after dosing and persisted for 9 h with decreasing severity. 3 Concurrent oral administration of Ro 15-1788 (200 mg) completely prevented the impairment in cognitive a...

  19. The influence of antiscalants on biofouling of RO membranes in seawater desalination.

    Science.gov (United States)

    Sweity, Amer; Oren, Yoram; Ronen, Zeev; Herzberg, Moshe

    2013-06-15

    Antiscalants are surface active polyelectrolyte compounds commonly used in reverse osmosis (RO) desalination processes to avoid membrane scaling. In spite of the significant roles of antiscalants in preventing membrane scaling, they are prone to enhance biofilm growth on RO membranes by either altering membrane surface properties or by serving as nutritional source for microorganisms. In this study, the contribution of antiscalants to membrane biofouling in seawater desalination was investigated. The effects of two commonly used antiscalants, polyphosphonate- and polyacrylate-based, were tested. The effects of RO membrane (DOW-Filmtec SW30 HRLE-400) exposure to antiscalants on its physico-chemical properties were studied, including the consequent effects on initial deposition and growth of the sessile microorganisms on the RO membrane surface. The effects of antiscalants on membrane physico-chemical properties were investigated by filtration of seawater supplemented with the antiscalants through flat-sheet RO membrane and changes in surface zeta potential and hydrophobicity were delineated. Adsorption of antiscalants to polyamide surfaces simulating RO membrane's polyamide layer and their effects on the consequent bacterial adhesion was tested using a quartz crystal microbalance with dissipation monitoring technology (QCM-D) and direct fluorescent microscopy. A significant increase in biofilm formation rate on RO membranes surface was observed in the presence of both types of antiscalants. Polyacrylate-based antiscalant was shown to enhance initial cell attachment as observed with the QCM-D and a parallel plate flow cell, due to rendering the polyamide surface more hydrophobic. Polyphosphonate-based antiscalants also increased biofilm formation rate, most likely by serving as an additional source of phosphorous to the seawater microbial population. A thicker biofilm layer was formed on the RO membrane when the polyacrylate-based antiscalant was used. Following

  20. Pharmaceuticals and pesticides in reclaimed water: Efficiency assessment of a microfiltration-reverse osmosis (MF-RO) pilot plant.

    Science.gov (United States)

    Rodriguez-Mozaz, Sara; Ricart, Marta; Köck-Schulmeyer, Marianne; Guasch, Helena; Bonnineau, Chloe; Proia, Lorenzo; de Alda, Miren Lopez; Sabater, Sergi; Barceló, Damià

    2015-01-23

    Water reuse is becoming a common practice in several areas in the world, particularly in those impacted by water scarcity driven by climate change and/or by rising human demand. Since conventional wastewater treatment plants (WWTPs) are not able to efficiently remove many organic contaminants and pathogens, more advanced water treatment processes should be applied to WWTP effluents for water reclamation purposes. In this work, a pilot plant based on microfiltration (MF) followed by reverse osmosis (RO) filtration was applied to the effluents of an urban WWTP. Both the WWTP and the pilot plant were investigated with regards to the removal of a group of relevant contaminants widely spread in the environment: 28 pharmaceuticals and 20 pesticides. The combined treatment by the MF-RO system was able to quantitatively remove the target micropollutants present in the WWTP effluents to values either in the low ng/L range or below limits of quantification. Monitoring of water quality of reclaimed water and water reclamation sources is equally necessary to design the most adequate treatment procedures aimed to water reuse for different needs.

  1. Effect of pH and Pressure on Uranium Removal from Drinking Water Using NF/RO Membranes.

    Science.gov (United States)

    Schulte-Herbrüggen, Helfrid M A; Semião, Andrea J C; Chaurand, Perrine; Graham, Margaret C

    2016-06-01

    Groundwater is becoming an increasingly important drinking water source. However, the use of groundwater for potable purposes can lead to chronic human exposure to geogenic contaminants, for example, uranium. Nanofiltration (NF) and reverse osmosis (RO) processes are used for drinking water purification, and it is important to understand how contaminants interact with membranes since accumulation of contaminants to the membrane surface can lead to fouling, performance decline and possible breakthrough of contaminants. During the current study laboratory experiments were conducted using NF (TFC-SR2) and RO (BW30) membranes to establish the behavior of uranium across pH (3-10) and pressure (5-15 bar) ranges. The results showed that important determinants of uranium-membrane sorption interactions were (i) the uranium speciation (uranium species valence and size in relation to membrane surface charge and pore size) and (ii) concentration polarization, depending on the pH values. The results show that it is important to monitor sorption of uranium to membranes, which is controlled by pH and concentration polarization, and, if necessary, adjust those parameters controlling uranium sorption.

  2. The Modified Fouling Index Ultrafiltration constant flux for assessing particulate/colloidal fouling of RO systems

    KAUST Repository

    Salinas-Rodriguez, Sergio G.

    2015-02-18

    Reliable methods for measuring and predicting the fouling potential of reverse osmosis (RO) feed water are important in preventing and diagnosing fouling at the design stage, and for monitoring pre-treatment performance during plant operation. The Modified Fouling Index Ultrafiltration (MFI-UF) constant flux is a significant development with respect to assessing the fouling potential of RO feed water. This research investigates (1) the variables influencing the MFI-UF test at constant flux filtration (membrane pore size, membrane material, flux rate); and (2) the application of MFI-UF into pre-treatment assessment and RO fouling estimation. The dependency of MFI on flux, means that to assess accurately particulate fouling in RO systems, the MFI should be measured at a flux similar to a RO system (close to 20 L/m2/h) or extrapolated from higher fluxes. The two studied membrane materials showed reproducible results; 10% for PES membranes and 6.3% for RC membranes. Deposition factors (amount of particles that remain on the surface of membrane) were measured in a full-scale plant ranging between 0.2 and 0.5. The concept of “safe MFI” is presented as a guideline for assessing pre-treatment for RO systems.

  3. Effects of the 5-HT(6) receptor antagonist Ro 04-6790 on learning consolidation.

    Science.gov (United States)

    Meneses, A

    2001-01-08

    The 5-HT(6) receptor antagonist Ro-04-6790 or 8-OH-DPAT injection improved learning consolidation on an autoshaping task, while mCPP, scopolamine and dizocilpine decreased the performance. The effect induced by scopolamine, but not that induced by mCPP, was reversed completely by Ro-04-6790, while dizocilpine effect was antagonized partially. Nevertheless, ritanserin or WAY 100635, but not Ro 04-6790, antagonized the 8-OH-DPAT facilitatory effects on learning consolidation. As WAY 100635 did not modify the Ro 04-6790 facilitatory effect, hence 5-HT(1A), and/or 5-HT(7), but not 5-HT(6), receptors might mediate the 8-OH-DPAT facilitatory effect on learning consolidation. Since, the Ro 04-6790 facilitatory effect was unaffected by 5-HT(1A), 5-HT(2A)/(2B)/(2C), 5-HT(3) or 5-HT(4) receptor blockade, thereby, the facilitatory effect induced by Ro 04-6790 involved specifically 5-HT(6) receptors. Indeed, the present data provide further support to the notion that, 5-HT(6) receptors play a significant part in the learning consolidation under normal and dysfunctional memory conditions.

  4. The high-energy environment in the super-earth system CoRoT-7

    CERN Document Server

    Poppenhaeger, K; Schröter, S; Lalitha, S; Kashyap, V; Schmitt, J H M M

    2012-01-01

    High-energy irradiation of exoplanets has been identified to be a key influence on the stability of these planets' atmospheres. So far, irradiation-driven mass-loss has been observed only in two Hot Jupiters, and the observational data remain even more sparse in the super-earth regime. We present an investigation of the high-energy emission in the CoRoT-7 system, which hosts the first known transiting super-earth. To characterize the high-energy XUV radiation field into which the rocky planets CoRoT-7b and CoRoT-7c are immersed, we analyzed a 25 ks XMM-Newton observation of the host star. Our analysis yields the first clear (3.5 sigma) X-ray detection of CoRoT-7. We determine a coronal temperature of ca. 3 MK and an X-ray luminosity of 3*10^28 erg/s. The level of XUV irradiation on CoRoT-7b amounts to ca. 37000 erg/cm^2/s. Current theories for planetary evaporation can only provide an order-of-magnitude estimate for the planetary mass loss; assuming that CoRoT-7b has formed as a rocky planet, we estimate that...

  5. Characterisation of residual ionospheric errors in bending angles using GNSS RO end-to-end simulations

    Science.gov (United States)

    Liu, C. L.; Kirchengast, G.; Zhang, K. F.; Norman, R.; Li, Y.; Zhang, S. C.; Carter, B.; Fritzer, J.; Schwaerz, M.; Choy, S. L.; Wu, S. Q.; Tan, Z. X.

    2013-09-01

    Global Navigation Satellite System (GNSS) radio occultation (RO) is an innovative meteorological remote sensing technique for measuring atmospheric parameters such as refractivity, temperature, water vapour and pressure for the improvement of numerical weather prediction (NWP) and global climate monitoring (GCM). GNSS RO has many unique characteristics including global coverage, long-term stability of observations, as well as high accuracy and high vertical resolution of the derived atmospheric profiles. One of the main error sources in GNSS RO observations that significantly affect the accuracy of the derived atmospheric parameters in the stratosphere is the ionospheric error. In order to mitigate the effect of this error, the linear ionospheric correction approach for dual-frequency GNSS RO observations is commonly used. However, the residual ionospheric errors (RIEs) can be still significant, especially when large ionospheric disturbances occur and prevail such as during the periods of active space weather. In this study, the RIEs were investigated under different local time, propagation direction and solar activity conditions and their effects on RO bending angles are characterised using end-to-end simulations. A three-step simulation study was designed to investigate the characteristics of the RIEs through comparing the bending angles with and without the effects of the RIEs. This research forms an important step forward in improving the accuracy of the atmospheric profiles derived from the GNSS RO technique.

  6. HIGH-PURITY WATER PRODUCTION BY RO/EDI SYSTEM

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    @@ Electrodeionization(EDI),also known as continuous deionization(CDI)and packed-cell electrodialysis,is a novel hybrid separation process combining ion-exchange resin with ion-exchange membrane in one unit.The EDI process was discovered in the 1950's[1,2]in laboratory,the first commercial apparatus for the production of high-purity water was available in 1987[3].Now the EDI technology has been found and will be continuously found its great applications in many engineering fields. In EDI,the dilute compartments are filled with mixed-bed ion-exchange resins,which enhance the transport to the membranes under the force of a direct current.The ion transport is almost entire through the ion-exchange resins and is not effected through the water.Under certain conditions,water-splitting reaction occurs in the dilute chambers and then the relative high concentrations of H+ and OH- are able to regenerate the resins continuously, With the unique “electroregeneration",the EDI unit can be considered as a mixed-bed ion-exchange column with continuous regeneration.and therefore is capable of deep deionization.Comparing with electrodialysis and ion exchange respectively,EDI has put up much superiority in water desalination. In our experiments,the processes for production of high-purity water from tap water are consisted of pretreatment (with ultrafiltration,active carbon and 10 μm-filtration),RO and EDI.

  7. Unravelling Boléro: progressive aphasia, transmodal creativity and the right posterior neocortex.

    Science.gov (United States)

    Seeley, William W; Matthews, Brandy R; Crawford, Richard K; Gorno-Tempini, Maria Luisa; Foti, Dean; Mackenzie, Ian R; Miller, Bruce L

    2008-01-01

    Most neurological lesion studies emphasize performance deficits that result from focal brain injury. Here, we describe striking gains of function in a patient with primary progressive aphasia, a degenerative disease of the human language network. During the decade before her language deficits arose, Anne Adams (AA), a lifelong scientist, developed an intense drive to produce visual art. Paintings from AA's artistic peak revealed her capacity to create expressive transmodal art, such as renderings of music in paint, which may have reflected an increased subjective relatedness among internal perceptual and conceptual images. AA became fascinated with Maurice Ravel, the French composer who also suffered from a progressive aphasia, and painted his best-known work, 'Boléro', by translating its musical elements into visual form. Later paintings, achieved when AA was nearly mute, moved towards increasing photographic realism, perhaps because visual representations came to dominate AA's mental landscape during this phase of her illness. Neuroimaging analyses revealed that, despite severe degeneration of left inferior frontal-insular, temporal and striatal regions, AA showed increased grey matter volume and hyperperfusion in right posterior neocortical areas implicated in heteromodal and polysensory integration. The findings suggest that structural and functional enhancements in non-dominant posterior neocortex may give rise to specific forms of visual creativity that can be liberated by dominant inferior frontal cortex injury.

  8. Transiting exoplanets from the CoRoT space mission VIII. CoRoT-7b: the first Super-Earth with measured radius

    CERN Document Server

    Léger, A; Schneider, J; Barge, P; Fridlund, M; Samuel, B; Ollivier, M; Günther, E; Deleuil, M; Deeg, H J; Auvergne, M; Alonso, R; Aigrain, S; Alapini, A; Almenara, J M; Baglin, A; Barbieri, M; Bruntt, H; Borde, P; Bouchy, F; Cabrera, J; Catala, C; Carone, L; Carpano, S; Csizmadia, Sz; Dvorak, R; Erikson, A; Ferraz-Mello, S; Foing, B; Fressin, F; Gandolfi, D; Gillon, M; Gondoin, Ph; Grasset, O; Guillot, T; Hatzes, A; Hébrard, G; Jorda, L; Lammer, H; Llebaria, A; Loeillet, B; Mayor, M; Mazeh, T; Moutou, C; Paetzold, M; Pont, F; Queloz, D; Rauer, H; Renner, S; Samadi, R; Shporer, A; Sotin, Ch; Tingley, B; Wuchterl, G

    2009-01-01

    We report the discovery of very shallow (DF/F = 3.4 10-4), periodic dips in the light curve of an active V = 11.7 G9V star observed by the CoRoT satellite, which we interpret as due to the presence of a transiting companion. We describe the 3-colour CoRoT data and complementary ground-based observations that support the planetary nature of the companion. Methods. We use CoRoT color information, good angular resolution ground-based photometric observations in- and out- of transit, adaptive optics imaging, near-infrared spectroscopy and preliminary results from Radial Velocity measurements, to test the diluted eclipsing binary scenarios. The parameters of the host star are derived from optical spectra, which were then combined with the CoRoT light curve to derive parameters of the companion. We examine carefully all conceivable cases of false positives, and all tests performed support the planetary hypothesis. Blends with separation larger than 0.40 arcsec or triple systems are almost excluded with a 8 10-4 ris...

  9. Modulation of natural IgM autoantibodies to oxidative stress-related neo-epitopes on apoptotic cells in newborns of mothers with anti-Ro autoimmunity.

    Science.gov (United States)

    Grönwall, Caroline; Clancy, Robert M; Getu, Lelise; Lloyd, Katy A; Siegel, Don L; Reed, Joanne H; Buyon, Jill P; Silverman, Gregg J

    2016-09-01

    At birth, the human immune system already contains substantial levels of polymeric IgM, that include autoantibodies to neo-epitopes on apoptotic cells (ACs) that are proposed to play homeostatic and anti-inflammatory roles. Yet the biologic origins and developmental regulation of these naturally arising antibodies remain poorly understood. Herein, we report that levels of IgM-antibodies to malondialdehyde (MDA) protein adducts, a common type of in vivo generated oxidative stress-related neoepitope, directly correlate with the relative binding of neonatal-IgM to ACs. Levels of IgM to phosphorylcholine (PC), a natural antibody prevalent in adults, were relatively scant in cord blood, while there was significantly greater relative representation of IgM anti-MDA antibodies in newborns compared to adults. To investigate the potential interrelationships between neonatal IgM with pathogenic IgG-autoantibodies, we studied 103 newborns born to autoimmune mothers with IgG anti-Ro (i.e., 70 with neonatal lupus and 33 without neonatal lupus). In these subjects the mean levels of IgM anti-Ro60 were significantly higher than in the newborns from non-autoimmune mothers. In contrast, levels of IgM anti-MDA in IgG anti-Ro exposed neonates were significantly lower than in neonates from non-autoimmune mothers. The presence or absence of neonatal lupus did not appear to influence the total levels of IgM in the anti-Ro exposed newborns. Taken together, our studies provide evidence that the immune development of the natural IgM-repertoire may be affected, and become imprinted by, the transfer of maternal IgG into the fetus.

  10. TCR usage, gene expression and function of two distinct FOXP3(+)Treg subsets within CD4(+)CD25(hi) T cells identified by expression of CD39 and CD45RO.

    Science.gov (United States)

    Ye, Lingying; Goodall, Jane C; Zhang, Libin; Putintseva, Ekaterina V; Lam, Brian; Jiang, Lei; Liu, Wei; Yin, Jian; Lin, Li; Li, Ting; Wu, Xin; Yeo, Giles; Shugay, Mikhail; Chudakov, Dmitriy M; Gaston, Hill; Xu, Huji

    2016-03-01

    FOXP3+ regulatory T (Treg) cells are indispensable for immune homeostasis, but their study in humans is complicated by heterogeneity within Treg, the difficulty in purifying Tregs using surface marker expression (e.g. CD25) and the transient expression of FOXP3 by activated effector cells. Here, we report that expression of CD39 and CD45RO distinguishes three sub-populations within human CD4(+)CD25(hi) T cells. Initial phenotypic and functional analysis demonstrated that CD4(+)CD25(hi)CD39(+)CD45RO(+) cells had properties consistent with effector Treg, CD4(+)CD25(hi)CD39(-)CD45RO(-) cells were naïve Treg and CD4(+)CD25(hi)CD39(-)CD45RO(+) cells were predominantly non-Treg with effector T-cell function. Differences in these two newly identified Treg subsets were corroborated by studies of gene expression and TCR analysis. To apply this approach, we studied these two newly identified Treg subsets in ankylosing spondylitis, and showed impairment in both effector and naïve Treg. This work highlights the importance of discriminating Treg subsets to enable proper comparisons of immune regulatory capacity in healthy individuals and those with inflammatory disease.

  11. Efficiently Combining Water Reuse and Desalination through Forward Osmosis—Reverse Osmosis (FO-RO) Hybrids: A Critical Review

    OpenAIRE

    Gaetan Blandin; Verliefde, Arne R.D.; Joaquim Comas; Ignasi Rodriguez-Roda; Pierre Le-Clech

    2016-01-01

    Forward osmosis (FO) is a promising membrane technology to combine seawater desalination and water reuse. More specifically, in a FO-reverse osmosis (RO) hybrid process, high quality water recovered from the wastewater stream is used to dilute seawater before RO treatment. As such, lower desalination energy needs and/or water augmentation can be obtained while delivering safe water for direct potable reuse thanks to the double dense membrane barrier protection. Typically, FO-RO hybrid can be ...

  12. Anti-Ro/SSA antibodies and cardiac arrhythmias in the adult: facts and hypotheses.

    Science.gov (United States)

    Lazzerini, P E; Capecchi, P L; Laghi-Pasini, F

    2010-09-01

    It is well established that the passive trans-placental passage of anti-Ro/SSA antibodies from mother to foetus is associated with the risk to develop an uncommon syndrome named neonatal lupus (NLE), where the congenital heart block represents the most severe clinical feature. Recent evidence demonstrated that also adult heart, classically considered invulnerable to the anti-Ro/SSA antibodies, may represent a target of the arrhythmogenicity of these autoantibodies. In particular, the prolongation of the QTc interval appears the most frequent abnormality observed in adults with circulating anti-Ro/SSA antibodies, with some data suggesting an association with an increased risk of ventricular arrhythmias, also life threatening. Moreover, even though the association between anti-Ro/SSA antibodies and conduction disturbances is undoubtedly less evident in adults than in infants, from the accurate dissection of the literature data the possibility arises that sometimes also the adult cardiac conduction tissue may be affected by such antibodies. The exact arrhythmogenic mechanisms involved in foetus/newborns and adults, respectively, have not been completely clarified as yet. However, increasing evidence suggests that anti-Ro/SSA antibodies may trigger rhythm disturbances through an inhibiting cross-reaction with several cardiac ionic channels, particularly the calcium channels (L-type and T-type), but also the potassium channel hERG, whose different expression and involvement in the cardiac electrophysiology during lifespan might account for the occurrence of age-related differences.

  13. CoRoT-7 b: Super-Earth or Super-Io?

    CERN Document Server

    Barnes, Rory; Greenberg, Richard; Jackson, Brian; Kaib, Nathan A

    2009-01-01

    CoRoT-7 b, a planet about 70% larger than the Earth orbiting a Sun-like star, is the first-discovered rocky exoplanet, and hence has been dubbed a "super-Earth". Some initial studies suggested that since the planet is so close to its host star, it receives enough insolation to partially melt its surface. However, these past studies failed to take into consideration the role that tides may play in this system. Even if the planet's eccentricity has always been zero, we show that tidal decay of semi-major axis could have been large enough that the planet formed on a wider orbit which received less insolation. Moreover, CoRoT-7 b could be tidally heated at a rate that dominates its geophysics and drives extreme volcanism. In this case, CoRoT-7 b is a "super-Io" that, like Jupiter's volcanic moon, is dominated by volcanism and rapid resurfacing. Such heating could occur with an eccentricity of just 10^-5. This small value could be driven by CoRoT-7 c if its own eccentricity is larger than ~10^-4. CoRoT-7 b may be ...

  14. Limits to the presence of transiting circumbinary planets in CoRoT data

    CERN Document Server

    Klagyivik, P; Cabrera, J; Csizmadia, Sz; Almenara, J M

    2016-01-01

    The CoRoT mission during its flight-phase 2007-2012 delivered the light-curves for over 2000 eclipsing binaries. Data from the Kepler mission have proven the existence of several transiting circumbinary planets. Albeit light-curves from CoRoT have typically lower precision and shorter coverage, CoRoT's number of targets is similar to Kepler, and some of the known circumbinary planets could potentially be detected in CoRoT data as well. The aim of this work has been a revision of the entire CoRoT data-set for the presence of circumbinary planets, and the derivation of limits to the abundances of such planets. We developed a code which removes the light curve of the eclipsing binaries and searches for quasi-periodic transit-like features in a light curve after removal of binary eclipses and instrumental features. The code needs little information on the sample systems and can be used for other space missions as well, like Kepler, K2, TESS and PLATO. The code is broad in the requirements leading to detections, b...

  15. Periodic variable stars in CoRoT field LRa02 observed with BEST II

    CERN Document Server

    Kabath, P; Rauer, H; Pasternacki, T; Csizmadia, Sz; Chini, R; Lemke, R; Murphy, M; Fruth, T; Titz, R; Eigmueller, P

    2009-01-01

    The Berlin Exoplanet Search Telescope II (BEST II) is a small wide field-of-view photometric survey telescope system located at the Observatorio Cerro Armazones, Chile. The high duty cycle combined with excellent observing conditions and millimagnitude photometric precision makes this instrument suitable for ground based support observations for the CoRoT space mission. Photometric data of the CoRoT LRa02 target field collected between November 2008 and March 2009 were analysed for stellar variability. The presented results will help in the future analysis of the CoRoT data, particularly in additional science programs related to variable stars. BEST II observes selected CoRoT target fields ahead of the space mission. The photometric data acquired are searched for stellar variability, periodic variable stars are identified with time series analysis of the obtained stellar light curves. We obtained the light curves of 104335 stars in the CoRoT LRa02 field over 41 nights. Variability was detected in light curves...

  16. Transiting exoplanets from the CoRoT space mission. XXVII. CoRoT-28b, a planet orbiting an evolved star, and CoRoT-29b, a planet showing an asymmetric transit

    Science.gov (United States)

    Cabrera, J.; Csizmadia, Sz.; Montagnier, G.; Fridlund, M.; Ammler-von Eiff, M.; Chaintreuil, S.; Damiani, C.; Deleuil, M.; Ferraz-Mello, S.; Ferrigno, A.; Gandolfi, D.; Guillot, T.; Guenther, E. W.; Hatzes, A.; Hébrard, G.; Klagyivik, P.; Parviainen, H.; Pasternacki, Th.; Pätzold, M.; Sebastian, D.; Tadeu dos Santos, M.; Wuchterl, G.; Aigrain, S.; Alonso, R.; Almenara, J.-M.; Armstrong, J. D.; Auvergne, M.; Baglin, A.; Barge, P.; Barros, S. C. C.; Bonomo, A. S.; Bordé, P.; Bouchy, F.; Carpano, S.; Chaffey, C.; Deeg, H. J.; Díaz, R. F.; Dvorak, R.; Erikson, A.; Grziwa, S.; Korth, J.; Lammer, H.; Lindsay, C.; Mazeh, T.; Moutou, C.; Ofir, A.; Ollivier, M.; Pallé, E.; Rauer, H.; Rouan, D.; Samuel, B.; Santerne, A.; Schneider, J.

    2015-07-01

    Context. We present the discovery of two transiting extrasolar planets by the satellite CoRoT. Aims: We aim at a characterization of the planetary bulk parameters, which allow us to further investigate the formation and evolution of the planetary systems and the main properties of the host stars. Methods: We used the transit light curve to characterize the planetary parameters relative to the stellar parameters. The analysis of HARPS spectra established the planetary nature of the detections, providing their masses. Further photometric and spectroscopic ground-based observations provided stellar parameters (log g, Teff, v sin i) to characterize the host stars. Our model takes the geometry of the transit to constrain the stellar density into account, which when linked to stellar evolutionary models, determines the bulk parameters of the star. Because of the asymmetric shape of the light curve of one of the planets, we had to include the possibility in our model that the stellar surface was not strictly spherical. Results: We present the planetary parameters of CoRoT-28b, a Jupiter-sized planet (mass 0.484 ± 0.087 MJup; radius 0.955 ± 0.066 RJup) orbiting an evolved star with an orbital period of 5.208 51 ± 0.000 38 days, and CoRoT-29b, another Jupiter-sized planet (mass 0.85 ± 0.20 MJup; radius 0.90 ± 0.16 RJup) orbiting an oblate star with an orbital period of 2.850 570 ± 0.000 006 days. The reason behind the asymmetry of the transit shape is not understood at this point. Conclusions: These two new planetary systems have very interesting properties and deserve further study, particularly in the case of the star CoRoT-29. The CoRoT space mission, launched on December 27th 2006, was developed and is operated by CNES, with the contribution of Austria, Belgium, Brazil, ESA (RSSD and Science Programme), Germany, and Spain. Based on observations obtained with the Nordic Optical Telescope, operated on the island of La Palma jointly by Denmark, Finland, Iceland

  17. Research and development of Ro-boat: an autonomous river cleaning robot

    Science.gov (United States)

    Sinha, Aakash; Bhardwaj, Prashant; Vaibhav, Bipul; Mohommad, Noor

    2013-12-01

    Ro-Boat is an autonomous river cleaning intelligent robot incorporating mechanical design and computer vision algorithm to achieve autonomous river cleaning and provide a sustainable environment. Ro-boat is designed in a modular fashion with design details such as mechanical structural design, hydrodynamic design and vibrational analysis. It is incorporated with a stable mechanical system with air and water propulsion, robotic arms and solar energy source and it is proceed to become autonomous by using computer vision. Both "HSV Color Space" and "SURF" are proposed to use for measurements in Kalman Filter resulting in extremely robust pollutant tracking. The system has been tested with successful results in the Yamuna River in New Delhi. We foresee that a system of Ro-boats working autonomously 24x7 can clean a major river in a city on about six months time, which is unmatched by alternative methods of river cleaning.

  18. Removal of bisphenol A (BPA) from water by various nanofiltration (NF) and reverse osmosis (RO) membranes.

    Science.gov (United States)

    Yüksel, Suna; Kabay, Nalan; Yüksel, Mithat

    2013-12-15

    The removal of an endocrine disrupting compound, bisphenol A (BPA), from model solutions by selected nanofiltration (NF) and reverse osmosis (RO) membranes was studied. The commercially available membranes NF 90, NF 270, XLE BWRO, BW 30 (Dow FilmTech), CE BWRO and AD SWRO (GE Osmonics) were used to compare their performances for BPA removal. The water permeability coefficients, rejection of BPA and permeate flux values were calculated for all membranes used. No significant changes in their BPA removal were observed for all tight polyamide based NF and RO membranes tested except for loose NF 270 membrane. The polyamide based membranes exhibited much better performance than cellulose acetate membrane for BPA removal. Almost a complete rejection (≥ 98%) for BPA was obtained with three polyamide based RO membranes (BW 30, XLE BWRO and AD SWRO). But cellulose acetate based CE BWRO membrane offered a low and variable (10-40%) rejection for BPA.

  19. Study of HD 169392A observed by CoRoT and HARPS

    CERN Document Server

    Mathur, S; Catala, C; Benomar, O; Davies, G R; Garcia, R A; Salabert, D; Ballot, J; Mosser, B; Regulo, C; Chaplin, W J; Elsworth, Y; Handberg, R; Hekker, S; Mantegazza, L; Michel, E; Poretti, E; Rainer, M; Roxburgh, I W; Samadi, R; Steslicki, M; Uytterhoeven, K; Verner, G A; Auvergne, M; Baglin, A; Forteza, S Barcelo; Baudin, F; Cortes, T Roca

    2012-01-01

    The numerous results obtained with asteroseismology thanks to space missions such as CoRoT and Kepler are providing a new insight on stellar evolution. After five years of observations, CoRoT is going on providing high-quality data. We present here the analysis of the double star HD169392 complemented by ground-based spectroscopic observations. This work aims at characterizing the fundamental parameters of the two stars, their chemical composition, the acoustic-mode global parameters including their individual frequencies, and their dynamics. We have analysed HARPS observations of the two stars to retrieve their chemical compositions. Several methods have been used and compared to measure the global properties of acoustic modes and their individual frequencies from the photometric data of CoRoT. The new spectroscopic observations and archival astrometric values suggest that HD169392 is a wide binary system weakly bounded. We have obtained the spectroscopic parameters for both components, suggesting the origin...

  20. Radial velocity follow-up of CoRoT transiting exoplanets

    Directory of Open Access Journals (Sweden)

    Deleuil M.

    2011-02-01

    Full Text Available We report on the results from the radial-velocity follow-up program performed to establish the planetary nature and to characterize the transiting candidates discovered by the space mission CoRoT. We use the SOPHIE at OHP, HARPS at ESO and the HIRES at Keck spectrographs to collect spectra and high-precision radial velocity (RV measurements for several dozens different candidates from CoRoT. We have measured the Rossiter-McLaughlin effect of several confirmed planets, especially CoRoT-1b which revealed that it is another highly inclined system. Such high-precision RV data are necessary for the discovery of new transiting planets. Furthermore, several low mass planet candidates have emerged from our Keck and HARPS data.

  1. The NStED Periodogram Service and Interface for Public CoRoT Data

    CERN Document Server

    von Braun, K; Beekley, A; Berriman, G B; Bryden, G; Chan, B; Ciardi, D R; Good, J; Harbut, M; Kane, S R; Laity, A; Lau, C; Lynn, M; McElroy, D; Plavchan, P; Regelson, M; Rey, R; Ramirez, S V; Stauffer, J; Zhang, A

    2011-01-01

    As part of the NASA-CNES agreement, the NASA Star and Exoplanet Database (NStED) serves as the official US portal for the public CoRoT data products. NStED is a general purpose archive with the aim of providing support for NASA's planet finding and characterization goals. Consequently, the NASA Exoplanet Science Institute (NExScI) developed, and NStED adapted, a periodogram service for CoRoT data to determine periods of variability phenomena and create phased photometric light curves. Through the NStED periodogram interface, the user may choose three different period detection algorithms to use on any photometric time series product, or even upload and analyze their own data. Additionally, the NStED periodogram is remotely accessed by the CoRoT archive as part of its interface. NStED is available at {\\bf http://nsted.ipac.caltech.edu}.

  2. Uncovering the planets and stellar activity of CoRoT-7 using only radial velocities

    CERN Document Server

    Faria, J P; Brewer, B J; Figueira, P; Oshagh, M; Santerne, A; Santos, N C

    2016-01-01

    Stellar activity can induce signals in the radial velocities of stars, complicating the detection of orbiting low-mass planets. We present a method to determine the number of planetary signals present in radial-velocity datasets of active stars, using only radial-velocity observations. Instead of considering separate fits with different number of planets, we use a birth-death Markov chain Monte Carlo algorithm to infer the posterior distribution for the number of planets in a single run. In a natural way, the marginal distributions for the orbital parameters of all planets are also inferred. This method is applied to HARPS data of CoRoT-7. We confidently recover both CoRoT-7b and CoRoT-7c although the data show evidence for additional signals.

  3. Vacuum-Induced Coherence in Ultracold Photoassociative Ro-Vibrational Excitations

    CERN Document Server

    Das, Sumanta; Deb, Bimalendu

    2011-01-01

    We show that coherence between two excited ro-vibrational states belonging to the same molecular electronic configuration arises quite naturally due to their interaction with electromagnetic vacuum. For initial preparation of a molecule in the desired ro-vibrational states, we propose to employ the method of ultracold photoassociation. Spontaneous decay of the excited molecule then gives rise to vacuum induced coherence between the excited ro-vibrational states. We demonstrate theoretically an interesting interplay of effects due to vacuum induced coherence and photoassociation. We apply our theory to photoassociation of bosonic Ytterbium (^{174}Yb) atoms which appear to be a promising system for exploring such interplay. The effects discussed here can be important for controlling decoherence and dissipation in molecular systems.

  4. Report on the CoRoT Evolution and Seismic Tools Activity

    CERN Document Server

    Monteiro, M J P F G; Montalban, J; Christensen-Dalsgaard, J; Castro, M; Degl'Innocenti, S; Moya, A; Roxburgh, I W; Scuflaire, R; Baglin, A; Cunha, M S; Eggenberger, P; Fernandes, J; Goupil, M J; Hui-Bon-Hoa, A; Marconi, M; Marques, J P; Michel, E; Miglio, A; Morel, P; Pichon, B; Moroni, P G P; Provost, J; Ruoppo, A; Suárez, J C; Suran, M; Teixeira, T C

    2006-01-01

    We present the work undertaken by the Evolution and Seismic Tools Activity (ESTA) team of the CoRoT Seismology Working Group. We have focused on two main tasks: Task 1 - now finished - has aimed at testing, comparing and optimising seven stellar evolution codes which will be used to model the internal structure and evolution of the CoRoT target stars. Task 2, still underway, aims at testing, comparing and optimising different seismic codes used to calculate the oscillations of models for different types of stars. The results already obtained are quite satisfactory, showing minor differences between the different numerical tools provided the same assumptions on the physical parameters are made. This work gives us confidence on the numerical tools that will be available to interpret the future CoRoT seismic data.

  5. A Review on the Hemodialysis Reliable Outflow (HeRO) Graft for Haemodialysis Vascular Access.

    Science.gov (United States)

    Al Shakarchi, J; Houston, J G; Jones, R G; Inston, N

    2015-07-01

    With improved dialysis survival there are increasing numbers of patients who have exhausted definitive access options due to central venous stenosis and are maintaining dialysis on a central venous catheter. The Hemodialysis Reliable Outflow (HeRO) allows an alternative by providing a definitive access solution. The aim of this study is to systematically review the published outcomes of the HeRO graft and discuss the role in complex haemodialysis patients. Electronic databases were searched for studies assessing the use of the HeRO graft for dialysis in accordance with PRISMA published up to December 31 2014. The primary outcomes for this study were 1-year primary and secondary patency rates. Secondary outcomes were rates of dialysis access associated steal syndrome, HeRO-related bacteraemia rates and rates of interventions. Following strict inclusion/exclusion criteria, eight studies including 409 patients were included in our review. Primary and secondary pooled patency rates in this complex cohort of dialysis patients were found to be 21.9% (9.6-37.2%) and 59.4% (39.4-78%). The rate of dialysis access associated steal syndrome was low at 6.3% (1-14.7%) as was the range of HeRO-related bacteraemia (0.13-0.7 events per 1000 days). This literature review shows that the HeRO graft is an acceptable option for complex dialysis patients who are catheter dependent. Owing to device availability, published data are predominantly North American and further longer-term studies in other populations may be necessary. In this challenging patient group, randomized controlled trials are required to allow comparisons with alternative access options. Copyright © 2015 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.

  6. The study of Be stars with the CoRoT satellite

    Science.gov (United States)

    Diago, P. D.; Gutierrez-Soto, J.; Fabregat, J.; Suso, J.; COROT Be Team

    2011-11-01

    The CoRoT space mission, launched in December 2006, is a spacecraft devoted to the study of the stellar interiors and the exo-planet search. Concerning the seismology of the Be stars, the presence of pulsations in late-type Be stars is still a matter of controversy. It constitutes an important issue to establish the relationship between non-radial pulsations and the mass-loss mechanism in Be stars. In this field, the CoRoT satellite is providing data with an unprecedent quality and precision that is confirming non-radial pulsations in Be stars. The CoRoT Be Team is an international collaboration composed by members from France, Spain, Brazil and Belgium and is in charge of the exploitation and analysis of the Be stars data. In this work we present the highlighted results of the observed Be stars by CoRoT and the future prospects of the CoRoT Be Team. These results include the detection of the Be star HD 49 330 during an outburst phase and the measurement of the change in the oscillation spectrum during this rare event. These observations gave insight into the nature of the explosion. It will help to solve a question that has been pending for years: are oscillations the cause of the outbursts? Moreover, for the first time, the CoRoT satellite has detected simultaneously the rotational and the pulsational frequencies for the Be star HD 50 209, which constitutes a proof of the presence of pulsations in the Be stars. %J Highlights of Spanish Astrophysics VI, Proceedings of the IX Scientific Meeting of the Spanish Astronomical Society (SEA), held in Madrid, September 13 - 17, 2010, Eds.: M. R. Zapatero Osorio, J. Gorgas, J. Maiz Apellaniz, J. R. Pardo, and A. Gil de Paz., p. 531-531

  7. Transiting exoplanets from the CoRoT space mission. XVIII. CoRoT-18b: a massive hot Jupiter on a prograde, nearly aligned orbit

    Science.gov (United States)

    Hébrard, G.; Evans, T. M.; Alonso, R.; Fridlund, M.; Ofir, A.; Aigrain, S.; Guillot, T.; Almenara, J. M.; Auvergne, M.; Baglin, A.; Barge, P.; Bonomo, A. S.; Bordé, P.; Bouchy, F.; Cabrera, J.; Carone, L.; Carpano, S.; Cavarroc, C.; Csizmadia, Sz.; Deeg, H. J.; Deleuil, M.; Díaz, R. F.; Dvorak, R.; Erikson, A.; Ferraz-Mello, S.; Gandolfi, D.; Gibson, N.; Gillon, M.; Guenther, E.; Hatzes, A.; Havel, M.; Jorda, L.; Lammer, H.; Léger, A.; Llebaria, A.; Mazeh, T.; Moutou, C.; Ollivier, M.; Parviainen, H.; Pätzold, M.; Queloz, D.; Rauer, H.; Rouan, D.; Santerne, A.; Schneider, J.; Tingley, B.; Wuchterl, G.

    2011-09-01

    We report the detection of CoRoT-18b, a massive hot Jupiter transiting in front of its host star with a period of 1.9000693 ± 0.0000028 days. This planet was discovered thanks to photometric data secured with the CoRoT satellite combined with spectroscopic and photometric ground-based follow-up observations. The planet has a mass Mp = 3.47 ± 0.38 MJup, a radius Rp = 1.31 ± 0.18 RJup, and a density ρp = 2.2 ± 0.8 g cm-3. It orbits a G9V star with a mass M⋆ = 0.95 ± 0.15 M⊙, a radius R⋆ = 1.00 ± 0.13 R⊙, and arotation period Prot = 5.4 ± 0.4 days. The age of the system remains uncertain, with stellar evolution models pointing either to a few tens Ma or several Ga, while gyrochronology and lithium abundance point towards ages of a few hundred Ma. This mismatch potentially points to a problem in our understanding of the evolution of young stars, with possibly significant implications for stellar physics and the interpretation of inferred sizes of exoplanets around young stars. We detected the Rossiter-McLaughlin anomaly in the CoRoT-18 system thanks to the spectroscopic observation of a transit. We measured the obliquity ψ = 20° ± 20° (sky-projected value λ = -10° ± 20°), indicating that the planet orbits in the same way as the star is rotating and that this prograde orbit is nearly aligned with the stellar equator. The CoRoT space mission, launched on 2006 December 27, has been developed and is operated by CNES, with the contribution of Austria, Belgium, Brazil, ESA (RSSD and Science Programme), Germany and Spain.Table 2 is available in electronic form at http://www.aanda.org

  8. Transiting exoplanets from the CoRoT space mission. XX. CoRoT-20b: A very high density, high eccentricity transiting giant planet

    Science.gov (United States)

    Deleuil, M.; Bonomo, A. S.; Ferraz-Mello, S.; Erikson, A.; Bouchy, F.; Havel, M.; Aigrain, S.; Almenara, J.-M.; Alonso, R.; Auvergne, M.; Baglin, A.; Barge, P.; Bordé, P.; Bruntt, H.; Cabrera, J.; Carpano, S.; Cavarroc, C.; Csizmadia, Sz.; Damiani, C.; Deeg, H. J.; Dvorak, R.; Fridlund, M.; Hébrard, G.; Gandolfi, D.; Gillon, M.; Guenther, E.; Guillot, T.; Hatzes, A.; Jorda, L.; Léger, A.; Lammer, H.; Mazeh, T.; Moutou, C.; Ollivier, M.; Ofir, A.; Parviainen, H.; Queloz, D.; Rauer, H.; Rodríguez, A.; Rouan, D.; Santerne, A.; Schneider, J.; Tal-Or, L.; Tingley, B.; Weingrill, J.; Wuchterl, G.

    2012-02-01

    We report the discovery by the CoRoT space mission of a new giant planet, CoRoT-20b. The planet has a mass of 4.24 ± 0.23 MJup and a radius of 0.84 ± 0.04 RJup. With a mean density of 8.87 ± 1.10 g cm-3, it is among the most compact planets known so far. Evolutionary models for the planet suggest a mass of heavy elements of the order of 800 M⊕ if embedded in a central core, requiring a revision either of the planet formation models or both planet evolution and structure models. We note however that smaller amounts of heavy elements are expected by more realistic models in which they are mixed throughout the envelope. The planet orbits a G-type star with an orbital period of 9.24 days and an eccentricity of 0.56.The star's projected rotational velocity is vsini = 4.5 ± 1.0 km s-1, corresponding to a spin period of 11.5 ± 3.1 days if its axis of rotation is perpendicular to the orbital plane. In the framework of Darwinian theories and neglecting stellar magnetic breaking, we calculate the tidal evolution of the system and show that CoRoT-20b is presently one of the very few Darwin-stable planets that is evolving toward a triple synchronous state with equality of the orbital, planetary and stellar spin periods. The CoRoT space mission, launched on December 27th 2006, has been developed and is operated by CNES, with the contribution of Austria, Belgium, Brazil, ESA (RSSD and Science Programme), Germany, and Spain.

  9. Analysis of serum anti-Ro52 positive in 238 cases%238例血清抗Ro-52抗体阳性分析

    Institute of Scientific and Technical Information of China (English)

    潘丽; 张园园; 杨宇溪; 李胡焕; 潘宝龙

    2016-01-01

    目的 探讨抗Ro-52抗体在不同疾病中的临床应用价值及意义.方法 采用欧蒙免疫印迹法检测患者血清抗Ro-52抗体,回顾性分析238例阳性结果 构成比及与其他自身抗体的关系.结果 238例阳性结果 中,构成比较高分别为系统性红斑狼疮23.5%,类风湿性关节炎16.8%和干燥综合征16.0%.抗Ro-52常伴随抗SSA、抗SSB及抗RNP出现,主要见于SLE、SS及RA.结论 自身免疫性疾病的起始和发病机制尚不清楚,其诊断和鉴别诊断也较为复杂.抗Ro-52抗体可存在多种疾病,仅能作为患者存在自身免疫疾病可能的提示,并不具备高特异性.但作为高阳性率自身抗体,在联合检测中具有一定的辅助诊断及鉴别诊断价值.

  10. In-Building Wireless Distribution in legacy Multimode Fiber with an improved RoMMF system

    DEFF Research Database (Denmark)

    Visani, Davide; Petersen, Martin Nordal; Sorci, Francesca

    2012-01-01

    A radio over multimode fiber (RoMMF) system for in-building wireless distribution employing a directly modulated Fabry-Perot (FP) transmitter and the central launch technique is presented. The worst-case spurious free dynamic range (SFDR) exceeds 105 dB×Hz2/3 up to 525 m of OM2 multimode fiber (MMF......). Experimental and theoretical results are reported showing that this scheme outperforms a RoMMF system employing a distributed feed-back (DFB) laser diode (LD) and/or a mode scrambler to achieve overfilled launch (OFL). Long Term Evolution (LTE) signal transmission is achieved with high quality in terms...

  11. VLT transit and occultation photometry for the bloated planet CoRoT-1b

    OpenAIRE

    Gillon, Michaël; Demory, B. -O.; Triaud, A. H. M. J.; Barman, T; Hebb, L.; Montalban Iglesias, Josefa; Maxted, P.; Queloz, D; Deleuil, M.; Magain, Pierre

    2009-01-01

    We present VLT eclipse photometry for the giant planet CoRoT-1b. We observed a transit in the R-band filter and an occultation in a narrow filter centered on 2.09 microns. Our analysis of this new photometry and published radial velocities, in combination with stellar-evolutionary modeling, leads to a planetary mass and radius of 1.07 (+0.13,-0.18) M_Jup and 1.45 (+0.07,-0.13) R_Jup, confirming the very low density previously deduced from CoRoT photometry. The large occultation depth that we ...

  12. Anti-Ro/SSA antibodies and cardiac rhythm disturbances: Present and future perspectives.

    Science.gov (United States)

    Santos-Pardo, Irene; Villuendas, Roger; Salvador-Corres, Iñaki; Martínez-Morillo, Melania; Olivé, Alejandro; Bayes-Genis, Antoni

    2015-04-01

    Several case reports, small case series, and original research papers have recently suggested that the action of certain auto-antibodies related to connective tissue diseases may be responsible for significant cardiac rhythm disturbances in adults. The relationship between anti-Ro/SSA antibodies and congenital complete atrioventricular block is well recognized in the fetal heart. Herein we review the emerging evidences of the link to increased levels of anti-Ro/SSA antibodies with rhythm disorders of unknown origin in the adult. Confirmation of this distinct etiology may eventually be the basis for new therapies.

  13. Galactic Archaeology with CoRoT and APOGEE: Creating mock observations from a chemodynamical model

    Science.gov (United States)

    Anders, F.; Chiappini, C.; Rodrigues, T. S.; Piffl, T.; Mosser, B.; Miglio, A.; Montalbán, J.; Girardi, L.; Minchev, I.; Valentini, M.; Steinmetz, M.

    2016-09-01

    In a companion paper, we have presented the combined asteroseismic-spectroscopic dataset obtained from CoRoT light curves and APOGEE infra-red spectra for 606 solar-like oscillating red giants in two fields of the Galactic disc (CoRoGEE). We have measured chemical abundance patterns, distances, and ages of these field stars which are spread over a large radial range of the Milky Way's disc. Here we show how to simulate this dataset using a chemodynamical Galaxy model. We also demonstrate how the observation procedure influences the accuracy of our estimated ages.

  14. Galactic Archaeology with CoRoT and APOGEE: Creating mock observations from a chemodynamical model

    CERN Document Server

    Anders, F; Rodrigues, T S; Piffl, T; Mosser, B; Miglio, A; Montalbán, J; Girardi, L; Minchev, I; Valentini, M; Steinmetz, M

    2016-01-01

    In a companion paper, we have presented the combined asteroseismic-spectroscopic dataset obtained from CoRoT lightcurves and APOGEE infra-red spectra for 678 solar-like oscillating red giants in two fields of the Galactic disc (CoRoGEE). We have measured chemical abundance patterns, distances, and ages of these field stars which are spread over a large radial range of the Milky Way's disc. Here we show how to simulate this dataset using a chemodynamical Galaxy model. We also demonstrate how the observation procedure influences the accuracy of our estimated ages.

  15. Behavioural effects of the benzodiazepine receptor partial agonist RO 16-6028 in mice.

    Science.gov (United States)

    Belzung, C; Misslin, R; Vogel, E

    1989-01-01

    The imidazo-diazepinone RO 16-6028 is a benzodiazepine receptor partial agonist which exhibits some anti-conflict effects in the two-chambered light/dark test without significantly affecting the behaviour of mice confronted with the staircase test. In addition, this drug slightly reduced locomotion and more markedly rearing in a free exploration procedure. These results indicate that RO 16-6028 appears to produce some anxiolytic and sedative properties like full agonists, but with weaker magnitude. This could be related to the benzodiazepine partial agonistic profile of the compound.

  16. Multiple star systems observed with CoRoT and Kepler

    Directory of Open Access Journals (Sweden)

    Southworth John

    2015-01-01

    Full Text Available The CoRoT and Kepler satellites were the first space platforms designed to perform high-precision photometry for a large number of stars. Multiple systems display a wide variety of photometric variability, making them natural benefactors of these missions. I review the work arising from CoRoT and Kepler observations of multiple systems, with particular emphasis on eclipsing binaries containing giant stars, pulsators, triple eclipses and/or low-mass stars. Many more results remain untapped in the data archives of these missions, and the future holds the promise of K2, TESS and PLATO.

  17. Multiple star systems observed with CoRoT and Kepler (invited review)

    CERN Document Server

    Southworth, John

    2014-01-01

    The CoRoT and Kepler satellites were the first space platforms designed to perform high-precision photometry for a large number of stars. Multiple systems display a wide variety of photometric variability, making them natural benefactors of these missions. I review the work arising from CoRoT and Kepler observations of multiple systems, with particular emphasis on eclipsing binaries containing giant stars, pulsators, triple eclipses and/or low-mass stars. Many more results remain untapped in the data archives of these missions, and the future holds the promise of K2, TESS and PLATO.

  18. Transiting exoplanets from the CoRoT space mission VI. CoRoT-Exo-3b: The first secure inhabitant of the brown-dwarf desert

    CERN Document Server

    Deleuil, M; Alonso, R; Bouchy, F; Rouan, D

    2008-01-01

    Context. The CoRoT space mission routinely provides high-precision photometric measurements of thousands of stars that have been continuously observed for months. Aims. The discovery and characterization of the first very massive transiting planetary companion with a short orbital period is reported. Methods. A series of 34 transits was detected in the CoRoT light curve of an F3V star, observed from May to October 2007 for 152 days. The radius was accurately determined and the mass derived for this new transiting, thanks to the combined analysis of the light curve and complementary ground-based observations: high-precision radial-velocity measurements, on-off photometry, and high signal-to-noise spectroscopic observations. Results. CoRoT-Exo-3b has a radius of 1.01+-0.07 RJup and transits around its F3-type primary every 4.26 days in a synchronous orbit. Its mass of 21.66+-1.0 MJup, density of 26.4+-5.6 g cm^-3, and surface gravity of log g = 4.72 clearly distinguish it from the regular close-in planet popula...

  19. Transiting exoplanets from the CoRoT space mission II. CoRoT-Exo-2b: A transiting planet around an active G star

    CERN Document Server

    Alonso, R; Baglin, A; Ollivier, M; Moutou, C; Rouan, D; Deeg, H J; Aigrain, S; Almenara, J M; Barbieri, M; Barge, P; Benz, W; Bordé, P; Bouchy, F; De la Reza, R; Deleuil, M; Dvorak, R; Erikson, A; Fridlund, M; Gillon, M; Gondoin, P; Guillot, T; Hatzes, A; Hébrard, G; Kabath, P; Jorda, L; Lammer, H; Léger, A; Llebaria, A; Loeillet, B; Magain, P; Mayor, M; Mazeh, T; Pätzold, M; Pepe, F; Pont, F; Queloz, D; Rauer, H; Shporer, A; Schneider, J; Stecklum, B; Udry, S; Wuchterl, G

    2008-01-01

    Context. The CoRoT mission, a pioneer in exoplanet searches from space, has completed its first 150 days of continuous observations of ~12000 stars in the galactic plane. An analysis of the raw data identifies the most promising candidates and triggers the ground-based follow-up. Aims. We report on the discovery of the transiting planet CoRoT-Exo-2b, with a period of 1.743 days, and characterize its main parameters. Methods. We filter the CoRoT raw light curve of cosmic impacts, orbital residuals, and low frequency signals from the star. The folded light curve of 78 transits is fitted to a model to obtain the main parameters. Radial velocity data obtained with the SOPHIE, CORALIE and HARPS spectro-graphs are combined to characterize the system. The 2.5 min binned phase-folded light curve is affected by the effect of sucessive occultations of stellar active regions by the planet, and the dispersion in the out of transit part reaches a level of 1.09x10-4 in flux units. Results. We derive a radius for the planet...

  20. Consideration on the fire safety of Ro/Ro ships operating in the Three Gorges Reservoir of the Yangtze River%对长江三峡库区汽车滚装船消防安全的思考

    Institute of Scientific and Technical Information of China (English)

    倪晨敬

    2012-01-01

    近年来随着我国经济建设的不断发展,长江三峡库区滚装船运输日趋繁忙,繁荣背后有着一个不容忽视的问题:滚装船舶火灾事故居高不下那么究竞是何原因?我们又如何吸取教训加强滚装船舶的消防安全管理?笔者结合事故分析,对预防长江三峡库区汽车滚装船舶火灾事故提出几点思考和建议.%With the continuous devdopment of China's economic construction in recent years, the Ro/Ro ship traffic has been also increasing. However, behind the prosperity, we cannot ignore a serious issue, the high frequency of fire accidents revolving the Ro/Ro vessels. What is the root cause? What lessons we should learn? What action we should take to strengthen the fire protection onboard the Ro/Ro ships? The author, based on the accident analysis, provides in this paper some Comments and suggestions concerning lneasures to be taken to prevent fire accidents involving Ro/Ro ships carrying cars in the Three Gorges Reservoir of the Yangtze River.

  1. Establishment of rock bream Oplegnathus fasciatus embryo (RoBE-4) cells with cytolytic infection of red seabream iridovirus (RSIV).

    Science.gov (United States)

    Oh, So-Young; Nishizawa, Toyohiko

    2016-12-01

    Red seabream iridovirus (RSIV) is a member of genus Megalocytivirus in the family Iridoviridae. RSIV infection causes significant economic losses of marine-fishes in East Asian countries. Grunt fin (GF) cell line has been commonly used for culturing RSIV. However, it is not suitable for definite evaluation of infectivity titer of RSIV because cells infected with RSIV are not completely cytolysed. Thus, we established a new cell line, RoBE-4, from rock bream (Oplegnathus fasciatus) eyed-egg embryos in this study. Morphologically, RoBE-4 cells were fibroblastic-like. They have been stably grown over two-years with 60 passages using Leibovitz's L-15 medium containing 10% (v/v) fetal bovine serum. RoBE-4 cells infected with RSIV exhibited cytopathic effects (CPE) with cell rounding. They were cytolysed completely after ≥2 weeks of culture. Numerous RSIV particles with icosahedral morphology of approximately 122nm in diameter were observed in cytoplasmic area of infected RoBE-4 cells. The RSIV-suceptibility and amount of extracellular RSIV released by RoBE-4 cells were 100-fold higher than those by GF cells. RSIV cultured with RoBE-4 cells was highly virulent to rock bream in infection experiments. Therefore, using RoBE-4 cells instead of GF cells will enable accurate and sensitive measurement of RSIV infectivity. In addition, RoBE-4 cells might be used to produce RSIV vaccine in the future with significant reduction in cost.

  2. Der Bürocomputer in einem Informationsverbund : Erfahrungen mit einem computergestützten Büro-Informationssystem (COBIS)

    OpenAIRE

    Zimmermann, Harald H.

    1981-01-01

    Zimmermann beschreibt den Stand der Technik im Bereich der computergestützten Informations- und Kommunikationsprozesse im Büro (Büroautomatisierung) mit dem Schwerpunkt "Sprachverarbeitung mit dem Computer". Er geht auf das Projekt "COBIS - Labormodell eines textuellen Büro-Informations-Systems" ein und beschreibt die immer leichtere und verbesserte Integration von Kleincomputern in Informations- und Kommunikationsverbünde.

  3. Apoptosis and Redistribution of the Ro Autoantigen in Balb/c Mouse Like in Subacute Cutaneous Lupus Erythematosus

    Directory of Open Access Journals (Sweden)

    Rafael Herrera-Esparza

    2006-01-01

    Full Text Available In subacute cutaneous lupus eryhematosus (SCLE the cutaneous antigens constitute the main source of Ro and La autoantigens. The aim of this investigation was to demonstrate if UV light increases the availability of Ro autoantigen in the skin, also the blocking effect of Ac-DEVD-CMK a caspase inhibitor was assessed. For this purpose newborn Balb/c mice were UVB irradiated (5–30 mJ/cm2 equivalent to a moderate to severe sunburn. Animals were injected with monoclonal anti-Ro antibodies from SCLE patients. Apoptosis was also induced by anti-Fas antibody injection. Skin samples were examined by direct immunofluoresence, by TUNEL, and the expression of caspase 3 by RT-PCR. Major findings of present studies were: 1. UVB irradiation and anti-Fas induced apoptosis of keratinocytes. 2. Apoptosis redistribute the Ro antigen on cell surface and is better triggered by Ro antibody. 3. The caspase 3 inhibitor Ac-DEVD-CMK decreases the availability of Ro autoantigen in epidermis and prevents deposition of anti-Ro. In conclusion, the caspase pathway would be blocked to avoid anti-Ro deposition along skin; this finding would be a prospect in the treatment of SCLE patients.

  4. Increased expression of the CD45RO (memory) antigen on T cells in HIV-infected children.

    Science.gov (United States)

    Froebel, K S; Doherty, K V; Whitelaw, J A; Hague, R A; Mok, J Y; Bird, A G

    1991-01-01

    Expression of the CD45RO putative memory cell antigen on CD4 (helper) and CD8 (cytotoxic/suppressor) lymphocytes of children born to HIV-infected women was investigated using the UCHL1 antibody. Significantly raised numbers of CD45RO+ CD8 lymphocytes were found in all nine of the infected children compared with uninfected and control children. Expression of CD45RO on CD4 lymphocytes was variable; absolute numbers were not increased, although the percentage was increased in four out of nine infected children. All the infected children except two (who had comparatively low numbers of CD45RO+ CD8 cells) were clinically well, which suggests that an increase in CD45RO+ CD8 cells may be indicative of a functionally active immune response against HIV.

  5. Revisiting the transits of CoRoT-7b at a lower activity level

    CERN Document Server

    Barros, S C C; Deleuil, M; Diaz, R F; Csizmadia, Sz; Cabrera, J; Chaintreuil, S; Cameron, A Collier; Hatzes, A; Haywood, R; Lanza, A F; Aigrain, S; Alonso, R; Bordé, R; Bouchy, F; Deeg, H J; Erikson, A; Fridlund, M; Grziwa, S; Gandolfi, D; Guillot, T; Guenther, E; Leger, A; Moutou, C; Ollivier, M; Pasternacki, T; Patzold, M; Rauer, H; Rouan, D; Santerne, A; Schneider, J; Wuchterl, G

    2014-01-01

    CoRoT-7b, the first super-Earth with measured radius discovered, has opened the new field of rocky exoplanets characterisation. To better understand this interesting system, new observations were taken with the CoRoT satellite. During this run 90 new transits were obtained in the imagette mode. These were analysed together with the previous 151 transits obtained in the discovery run and HARPS radial velocity observations to derive accurate system parameters. A difference is found in the posterior probability distribution of the transit parameters between the previous CoRoT run (LRa01) and the new run (LRa06). We propose this is due to an extra noise component in the previous CoRoT run suspected to be transit spot occultation events. These lead to the mean transit shape becoming V-shaped. We show that the extra noise component is dominant at low stellar flux levels and reject these transits in the final analysis. We obtained a planetary radius, $R_p= 1.585\\pm0.064\\,R_{\\oplus}$, in agreement with previous estim...

  6. The Modified Fouling Index Ultrafiltration constant flux for assessing particulate/colloidal fouling of RO systems

    NARCIS (Netherlands)

    Salinas-Rodriguez, S.G.; Amy, G.L.; Schippers, J.C.; Kennedy, M.D.

    2015-01-01

    Reliable methods for measuring and predicting the fouling potential of reverse osmosis (RO) feed water are important in preventing and diagnosing fouling at the design stage, and for monitoring pre-treatment performance during plant operation. The Modified Fouling Index Ultrafiltration (MFI-UF) cons

  7. Spectral characterization and differential rotation study of active CoRoT stars

    CERN Document Server

    Nagel, Evangelos; Schmitt, Jürgen H M M

    2016-01-01

    The CoRoT space telescope observed nearly 160 000 light curves. Among the most outstanding is that of the young, active planet host star CoRoT-2A. In addition to deep planetary transits, the light curve of CoRoT-2A shows strong rotational variability and a superimposed beating pattern. To study the stars that produce such an intriguing pattern of photometric variability, we identified a sample of eight stars with rotation periods between 0.8 and 11 days and photometric variability amplitudes of up to 7.5 %, showing a similar CoRoT light curve. We also obtained high-resolution follow-up spectroscopy with TNG/SARG and carried out a spectral analysis with SME and MOOG. We find that the color dependence of the light curves is consistent with rotational modulation due to starspots and that latitudinal differential rotation provides a viable explanation for the light curves, although starspot evolution is also expected to play an important role. Our MOOG and SME spectral analyses provide consistent results, showing...

  8. Approximation of functions in Besov space by deferred Cesàro mean

    Directory of Open Access Journals (Sweden)

    Mradul Veer Singh

    2016-04-01

    Full Text Available Abstract In this paper we study the degree of approximation of functions (signals in a Besov space by trigonometric polynomials using deferred Cesàro mean. We also deduce a few corollaries of our main result and compare them with the existing results.

  9. Comparative in vitro activity of Ro 09-1428, a novel cephalosporin with a catechol moiety.

    Science.gov (United States)

    Qadri, S M; Ayub, A; Ueno, Y; Saldin, H

    1992-01-01

    The in vitro activity of Ro 09-1428, a new parenteral cephalosporin, was compared with that of other beta-lactams and aminoglycosides in 1230 clinical isolates from 1028 consecutive patients. Using an agar dilution method, the drugs were tested against 625 isolates of Enterobacteriaceae, 68 Pseudomonas aeruginosa, 36 Xanthomonas maltophilia, 20 Aeromonas hydrophila, 54 Acinetobacter, 373 staphylococci, and 54 strains of enterococci. More than 98% of Enterobacteriaceae were susceptible to Ro 09-1428, with a minimal inhibitory concentration of less than 0.03 to 4.0 micrograms/ml. Ro 09-1428 also inhibited 99% and 72% of the clinical isolates of P aeruginosa and X maltophilia, respectively. All isolates of methicillin-susceptible Staphylococcus aureus (MSSA) were susceptible to this cephalosporin. However, only 46% of the 54 strains of enterococci exhibited in vitro susceptibility. Ro 09-1428 was found to be superior or comparable to most penicillins, cephalosporins, and aminoglycosides against both gram-negative bacteria and MSSA.

  10. Mixed modes in red-giant stars observed with CoRoT

    NARCIS (Netherlands)

    Mosser, B.; Barban, C.; Montalban, J.; Beck, P.G.; Miglio, A.; Belkacem, K.; Goupil, M.J.; Hekker, S.; de Ridder, J.; Dupret, M.A.; Elsworth, Y.; Noels, A.; Baudin, F.; Michel, A.E.; Samadi, R.; Auvergne, M.; Baglin, A.; Catala, C.

    2011-01-01

    Context. The CoRoT mission has provided thousands of red-giant light curves. The analysis of their solar-like oscillations allows us to characterize their stellar properties. Aims. Up to now, the global seismic parameters of the pressure modes have been unable to distinguish red-clump giants from

  11. Using SDI, SDI+ and MFI to evaluate fouling in a UR/RO desalination pilot plant

    NARCIS (Netherlands)

    Al-Hadidi, A.M.M.; Kemperman, A.J.B.; Schurer, H.; Schippers, J.C.; Wessling, M.; Meer, van der W.G.J.

    2012-01-01

    This paper assesses the performance of a UF/RO demonstration plant located in the Oosterschelde estuary in the south-western part of the Netherlands. Spring blooms in the seawater pose a challenge to the plant because of the resulting increased fouling potential of the water. Determinations of the f

  12. EFÜN ja RoGer tunnustasid õppejõude / Mari Peetris

    Index Scriptorium Estoniae

    Peetris, Mari

    2008-01-01

    Tallinna Ülikooli Germaani-Romaani Keelte ja Kultuuride Instituudi üliõpilasnõukogu RoGer ja Eesti Keele ja Kultuuri Instituudi üliõpilasnõukogud avaldasid tänu kõige üliõpilassõbralikematele õppejõududele

  13. Stellar hydrodynamics caught in the act: Asteroseismology with CoRoT and Kepler

    DEFF Research Database (Denmark)

    Christensen-Dalsgaard, Jørgen; Thompson, Michael J.

    2011-01-01

    Asteroseismic investigations, particularly based on data on stellar oscillations from the CoRoT and Kepler space missions, are providing unique possibilities for investigating the properties of stellar interiors. This constitutes entirely new ways to study the effects of dynamic phenomena on stel...... obtained from such investigations, across the Hertzsprung-Russell diagram....

  14. Bright optical dayside emission from extrasolar planet CoRoT-2b

    CERN Document Server

    Snellen, I A G; Burrows, A

    2009-01-01

    We present our analysis of the red-channel CoRoT data of extrasolar planet CoRoT-2b. A deep secondary eclipse is detected at a level of 1.02+-0.20x10^-4, which suggests that all of the planet-signal detected previously in white light by Alonso et al. (2009) originates from the red channel. CoRoT-2b is the coolest exoplanet that has been detected in the optical so far. In contrast to the other planets, its measured brightness temperature of 2170+-50 K is significantly higher than its maximum hemisphere-averaged effective day-side temperature. However, it is not expected that a hot Jupiter radiates as a black body, and its thermal spectrum can deviate significantly from a Planck curve. We present models of the planet/star flux ratio as function of wavelength, which are calculated for a T/P profile in radiative and hydrostatic equilibrium, using a self-consistent atmosphere code. These are compared with the CoRoT detection. We estimate that reflected light contributes only at a 10-20% level to the total optical ...

  15. ÜRO - tõeliselt üleilmne foorum / Tiina Intelmann

    Index Scriptorium Estoniae

    Intelmann, Tiina, 1963-

    2007-01-01

    Eesti Vabariigi alaline esindaja ÜRO juures tutvustab maailmaorganisatsiooni põhikirjalisi eesmärke, globaliseerumise mõjusid tegevusele, raskusi rahvusvaheliste kokkulepete täitmisel, rahuvalve ja kohtupidamisega seotud küsimusi ning igapäevatööd

  16. The LAEX and NASA portals for CoRoT public data

    CERN Document Server

    Solano, E; Velasco, A; Ciardi, D R; Gutíerrez, R; McElroy, D L; López, M; Abajian, M; García, M; Ali, B; Sarro, L M; Berriman, G B; Bryden, G; Chan, B; Good, J; Kane, S R; Laity, A C; Lau, C; Payne, A N; Plavchan, P; Ramírez, S; Schmitz, M; Stauffer, J R; Wyatt, P L; Zhang, A

    2009-01-01

    * Aims. We describe here the main functionalities of the LAEX (Laboratorio de Astrofisica Estelar y Exoplanetas/Laboratory for Stellar Astrophysics and Exoplanets) and NASA portals for CoRoT Public Data. The CoRoT archive at LAEX was opened to the community in January 2009 and is managed in the framework of the Spanish Virtual Observatory. NStED (NASA Star and Exoplanet Database) serves as the CoRoT portal for the US astronomical community. NStED is a general purpose stellar and exoplanet archive with the aim of providing support for NASA planet finding and characterisation goals, and the planning and support of NASA and other space missions. CoRoT data at LAEX and NStED can be accessed at http://sdc.laeff.inta.es/corotfa/ and http://nsted.ipac.caltech.edu,respectively. * Methods. Based on considerable experience with astronomical archives, the aforementioned archives are designed with the aim of delivering science-quality data in a simple and efficient way. * Results. LAEX and NStED not only provide access t...

  17. Plantio direto de alface americana sobre plantas de cobertura dessecadas ou roçadas

    Directory of Open Access Journals (Sweden)

    Andréia Cristina Silva Hirata

    2014-06-01

    Full Text Available O objetivo deste trabalho foi avaliar o plantio direto de alface americana no verão sobre plantas de cobertura dessecadas ou roçadas em cultivos sucessivos. O trabalho foi desenvolvido no município de Álvares Machado, São Paulo, Brasil. O delineamento experimental foi em blocos ao acaso, dispostos em parcelas subdivididas, com quatro repetições. O fator da parcela principal foram dois manejos das plantas de cobertura (dessecadas com herbicida ou roçadas e as subparcelas, seis espécies de plantas de cobertura (Cajanus cajan cv. IAPAR 43, Crotalaria spectabilis, Crotalaria juncea, Mucuna pruriens, Pennisetum glaucum e vegetação natural, além da testemunha sem plantas de cobertura. O manejo roçado apresentou desempenho inferior no primeiro cultivo da alface, todavia não diferiu do manejo químico no segundo cultivo. A cobertura do solo com mucuna apresentou maior produtividade da alface no primeiro cultivo devido ao excesso de palha das demais coberturas, o qual prejudicou o estabelecimento da alface. No segundo cultivo não houve diferenças entre as coberturas. A roçagem de plantas de cobertura é uma opção viável para plantio direto de alface sem herbicidas.

  18. [Neonatal lupus erythematosus: complete atrioventricular block and SSA/Ro antibodies].

    Science.gov (United States)

    Prados, R; Maroto, E; López Longo, J; Monteagudo, I; Carreño, L; García, E J

    1987-06-01

    A newborn boy with complete A-V block and positive anti-SSA/Ro antibodies is reported. Authors comment on pathological findings of neonatal lupus erythematosus. They also review prognosis and clinical course and point out management of these patients before and after birth.

  19. EFÜN ja RoGer tunnustasid õppejõude / Mari Peetris

    Index Scriptorium Estoniae

    Peetris, Mari

    2008-01-01

    Tallinna Ülikooli Germaani-Romaani Keelte ja Kultuuride Instituudi üliõpilasnõukogu RoGer ja Eesti Keele ja Kultuuri Instituudi üliõpilasnõukogud avaldasid tänu kõige üliõpilassõbralikematele õppejõududele

  20. Spectral characterization and differential rotation study of active CoRoT stars

    Science.gov (United States)

    Nagel, E.; Czesla, S.; Schmitt, J. H. M. M.

    2016-05-01

    The CoRoT space telescope observed nearly 160 000 light curves. Among the most outstanding is that of the young, active planet host star CoRoT-2A. In addition to deep planetary transits, the light curve of CoRoT-2A shows strong rotational variability and a superimposed beating pattern. To study the stars that produce such an intriguing pattern of photometric variability, we identified a sample of eight stars with rotation periods between 0.8 and 11 days and photometric variability amplitudes of up to 7.5%, showing a similar CoRoT light curve. We also obtained high-resolution follow-up spectroscopy with TNG/SARG and carried out a spectral analysis with SME and MOOG. We find that the color dependence of the light curves is consistent with rotational modulation due to starspots and that latitudinal differential rotation provides a viable explanation for the light curves, although starspot evolution is also expected to play an important role. Our MOOG and SME spectral analyses provide consistent results, showing that the targets are dwarf stars with spectral types between F and mid-K. Detectable Li i absorption in four of the targets confirms a low age of 100-400 Myr also deduced from gyrochronology. Our study indicates that the photometric beating phenomenon is likely attributable to differential rotation in fast-rotating stars with outer convection zones.

  1. President Ilves kõneles Euroopa Liidu nimel ÜRO kliimakonverentsil

    Index Scriptorium Estoniae

    2007-01-01

    Ingl. k. lüh. lk. 9, pealk.: Ilves addresses UN on climate change. President Toomas Hendrik Ilves kõneles 24. septembril 2007 ÜRO peakorteris toimunud kliimakonverentsil, tehes seda Euroopa Liidu eesistujamaa Portugali palvel kogu Euroopa Liidu nimel. Vabariigi President töövisiidil Ameerika Ühendriikides 20.-26.09.2007

  2. Planetary transit candidates in the CoRoT-SRc01 field

    DEFF Research Database (Denmark)

    Erikson, A.; Santerne, A.; Renner, S.;

    2012-01-01

    Context. CoRoT is a pioneering space mission whose primary goals are stellar seismology and extrasolar planets search. Its surveys of large stellar fields generate numerous planetary candidates whose lightcurves have transit-like features. An extensive analytical and observational follow-up effor...

  3. Uncovering the planets and stellar activity of CoRoT-7 using only radial velocities

    Science.gov (United States)

    Faria, J. P.; Haywood, R. D.; Brewer, B. J.; Figueira, P.; Oshagh, M.; Santerne, A.; Santos, N. C.

    2016-04-01

    Stellar activity can induce signals in the radial velocities of stars, complicating the detection of orbiting low-mass planets. We present a method to determine the number of planetary signals present in radial-velocity datasets of active stars, using only radial-velocity observations. Instead of considering separate fits with different number of planets, we use a birth-death Markov chain Monte Carlo algorithm to infer the posterior distribution for the number of planets in a single run. In a natural way, the marginal distributions for the orbital parameters of all planets are also inferred. This method is applied to HARPS data of CoRoT-7. We confidently recover the orbits of both CoRoT-7b and CoRoT-7c although the data show evidence for the presence of additional signals. All data and software presented in this article are available online at http://https://github.com/j-faria/exoBD-CoRoT7

  4. Planets and Stellar Activity: Hide and Seek in the CoRoT-7 system

    CERN Document Server

    Haywood, R D; Queloz, D; Barros, S C C; Deleuil, M; Fares, R; Gillon, M; Lanza, A F; Lovis, C; Moutou, C; Pepe, F; Pollacco, D; Santerne, A; Segransan, D; Unruh, Y C

    2014-01-01

    Since the discovery of the transiting super-Earth CoRoT-7b, several investigations have yielded different results for the number and masses of planets present in the system, mainly owing to the star's high level of activity. We re-observed CoRoT-7 in January 2012 with both HARPS and CoRoT, so that we now have the benefit of simultaneous radial-velocity and photometric data. This allows us to use the off-transit variations in the star's light curve to estimate the radial-velocity variations induced by the suppression of convective blueshift and the flux blocked by starspots. To account for activity-related effects in the radial-velocities which do not have a photometric signature, we also include an additional activity term in the radial-velocity model, which we treat as a Gaussian process with the same covariance properties (and hence the same frequency structure) as the light curve. Our model was incorporated into a Monte Carlo Markov Chain in order to make a precise determination of the orbits of CoRoT-7b a...

  5. Planetary transit candidates in the CoRoT LRa01 field

    CERN Document Server

    Carone, L; Cabrera, J; Hatzes, A P; Deeg, H J; Csizmadia, Sz; Paetzold, M; Weingrill, J; Aigrain, S; Alonso, R; Alapini, A; Almenara, J -M; Auvergne, M; Baglin, A; Barge, P; Bonomo, A S; Bordé, P; Bouchy, F; Bruntt, H; Carpano, S; Cochran, W D; Deleuil, M; Díaz, R F; Dreizler, S; Dvorak, R; Eisloeffel, J; Eigmueller, P; Endl, M; Erikson, A; Ferraz-Mello, S; Fridlund, M; Gazzano, J -C; Gibson, N; Gillon, M; Gondoin, P; Grziwa, S; Guenther, E W; Guillot, T; Hartmann, M; Havel, M; Hébrard, G; Jorda, L; Kabath, P; Léger, A; Llebaria, A; Lammer, H; Lovis, C; MacQueen, P J; Mayor, M; Mazeh, T; Moutou, C; Nortmann, L; Ofir, A; Ollivier, M; Parviainen, H; Pepe, F; Pont, F; Queloz, D; Rabus, M; Rauer, H; Régulo, C; Renner, S; de la Reza, R; Rouan, D; Santerne, A; Samuel, B; Schneider, J; Shporer, A; Stecklum, B; Tal-Or, L; Tingley, B; Udry, S; Wuchterl, G

    2011-01-01

    Context: CoRoT is a pioneering space mission whose primary goals are stellar seismology and extrasolar planets search. Its surveys of large stellar fields generate numerous planetary candidates whose lightcurves have transit-like features. An extensive analytical and observational follow-up effort is undertaken to classify these candidates. Aims: The list of planetary transit candidates from the CoRoT LRa01 star field in the Monoceros constellation towards the Galactic anti-center is presented. The CoRoT observations of LRa01 lasted from 24 October 2007 to 3 March 2008. Methods: 7470 chromatic and 3938 monochromatic lightcurves were acquired and analysed. Instrumental noise and stellar variability were treated with several filtering tools by different teams from the CoRoT community. Different transit search algorithms were applied to the lightcurves. Results: Fifty-one stars were classified as planetary transit candidates in LRa01. Thirty-seven (i.e., 73 % of all candidates) are "good" planetary candidates ba...

  6. Rotation and oblique pulsation in Kepler observations of the roAp star KIC 10483436

    DEFF Research Database (Denmark)

    Balona, L. A.; Cunha, M. S.; Gruberbauer, M.

    2011-01-01

    Photometry of KIC 10483436 was obtained continuously with 1-min exposures over a 27-d period from the Kepler satellite. The light curve shows rotational variations from surface spots with a period of 4.303 ± 0.002 d, an amplitude of about 6 mmag and eight pulsation frequencies typical of roAp stars...

  7. Establishment of Stable SSA/Ro52 Gene Silencing Cell Lines by Lentiviral Vectors%通过慢病毒载体构建SSA/Ro52稳定基因沉默细胞系

    Institute of Scientific and Technical Information of China (English)

    郭娟; 周炜

    2014-01-01

    Objective ToestablishthestableSSA/Ro52genesilencingcelllinesbylentiviralvestorsexpressing RNA interference molecule which should be powerful tools facilitating the study of SSA/Ro52 function. Methods Four specific sequences of SSA/Ro52 (clone 1 TGGCATGGTCTCCTTCTACAA;clone 2 CTGCCT-TCTTTATGGGACTTA;clone 9 TGAGAAGTTGGAAGTGGAAAT;clone 1 1 AGTTATCCTATGGTCCTGG-GT)and unrelated control sequence S were cloned into lentiviral vector pLKO-puro,which could express short hairpin RNA (shRNA)and inhibit expression of specific gene by RNA interference mechanism. Clone 1,2,9,11 which expressing SSA/Ro52 specific sequences and control clone S were packed with pGag-Pol and pVSV-G respectively,then 293 T cells were co-transfected. Culture medium containing virus particles were collected. The viral particles which expressing specific sequences SSA/Ro52 and unrelated control sequences were used to infected Hela cells,after antibiotic selection,stable cell lines were established. We used GAPDH as an internal control in real-time PCR for the detecting of SSA/Ro52 mRNA expression. Immunoblot was performed to detect SSA/Ro52 protein expression. The degree of gene expression inhibition was represented by the ratio of SSA/Ro52 expression level in Clone1,2,9,11 transfected cells and that in cloneS.Results LentiviruseffectivelyinfectedHelacells,thevectorDNAcontainingshRNAexpressing cassette were integrated into the cellullar gemone and stable cell lines were established. After antibiotics screening for 3 days,compared to transfected cells,the control clone S,the mRNA level of SSA/Ro52 of the transfected cells Clone 1,2,9,11 were 25. 5%,31. 2%,13. 0% and 77. 2%,respectively. While the protein level of SSA/Ro52 in the experimental group were 5%,50%,10%and 80%. After 4 weeks of culture,SSA/Ro52 protein expression did not change significantly. After stimulated by interferonα(IFN-α), the transfected cells with control clone expressed increased level of SSA/Ro52 protein;while the protein level

  8. Anti-TNFa treatment in patients with rheumatoid arthritis and anti-Ro/SSA antibodies

    Directory of Open Access Journals (Sweden)

    P. Airò

    2011-09-01

    Full Text Available Objective: To analyse clinical efficacy, onset of new autoantibodies or symptoms of autoimmune disease in patients affected by rheumatoid arthritis with anti-Ro/SSA treated with anti-TNFa agents. Methods: Six anti-Ro/SSA positive subjects with RA were studied every six months until 24th month of treatment in order to detect ANA titer (IFI, anti-dsDNA (Farr, anti-cardiolipin and anti-beta2glycoprotein I (ELISA, anti-ENA (CIE. The titre of anti-Ro/SSA were analysed by ELISA. Four patients were diagnosed as overlap RA/SS. Results: Six female patients (mean age 58ys, SD 9.8ys, with long-standing RA (mean 7ys, range 5-22 ys were treated with anti-TNFa agents for a mean of 31 months (SD: 20.4 m: 4 with Infliximab and 2 with Etanercept. All the patients showed a significant reduction of DAS until 24th month (p<0.006 with stability of sicca symptoms. The titer of ANA and anti-Ro/SSA was stable, while 4 subjects developed anti-dsDNA at low titer within 6-12 months. One patient withdrawn the treatment, because of lupus-like features; another one, with HCV hepatitis, interrupted Etanercept because of elevation of liver enzymes. No anticardiolipin or antibeta2GPI antibodies were detected. One subject with RA-SS also presented a primary biliary cirrhosis: clinical and histological features of cholangitis remained stable during Etanercept treatment. Conclusions: Anti-TNFa treatment showed good efficacy and safety in anti-Ro/SSA positive patients with RA. Anti-ds- DNA antibodies at low titer appeared in most patients while the onset of lupus-like disease could be considered a rare event also in RA patients with a rich autoimmune repertoire.

  9. Quantum Calculation of Inelastic CO Collisions with H. III. Rate Coefficients for Ro-vibrational Transitions

    Science.gov (United States)

    Song, L.; Balakrishnan, N.; Walker, K. M.; Stancil, P. C.; Thi, W. F.; Kamp, I.; van der Avoird, A.; Groenenboom, G. C.

    2015-11-01

    We present calculated rate coefficients for ro-vibrational transitions of CO in collisions with H atoms for a gas temperature range of 10 K ≤ T ≤ 3000 K, based on the recent three-dimensional ab initio H-CO interaction potential of Song et al. Rate coefficients for ro-vibrational v=1,j=0-30\\to v\\prime =0,j\\prime transitions were obtained from scattering cross sections previously computed with the close-coupling (CC) method by Song et al. Combining these with the rate coefficients for vibrational v=1-5\\to v\\prime \\lt v quenching obtained with the infinite-order sudden approximation, we propose a new extrapolation scheme that yields the rate coefficients for ro-vibrational v=2-5,j=0-30\\to v\\prime ,j\\prime de-excitation. Cross sections and rate coefficients for ro-vibrational v=2,j=0-30\\to v\\prime =1,j\\prime transitions calculated with the CC method confirm the effectiveness of this extrapolation scheme. Our calculated and extrapolated rates are very different from those that have been adopted in the modeling of many astrophysical environments. The current work provides the most comprehensive and accurate set of ro-vibrational de-excitation rate coefficients for the astrophysical modeling of the H-CO collision system. The application of the previously available and new data sets in astrophysical slab models shows that the line fluxes typically change by 20%-70% in high temperature environments (800 K) with an H/H2 ratio of 1; larger changes occur for lower temperatures.

  10. Pre-clinical studies of Notch signaling inhibitor RO4929097 in inflammatory breast cancer cells.

    Science.gov (United States)

    Debeb, Bisrat G; Cohen, Evan N; Boley, Kimberly; Freiter, Erik M; Li, Li; Robertson, Fredika M; Reuben, James M; Cristofanilli, Massimo; Buchholz, Thomas A; Woodward, Wendy A

    2012-07-01

    Basal breast cancer, common among patients presenting with inflammatory breast cancer (IBC), has been shown to be resistant to radiation and enriched in cancer stem cells. The Notch pathway plays an important role in self-renewal of breast cancer stem cells and contributes to inflammatory signaling which promotes the breast cancer stem cell phenotype. Herein, we inhibited Notch signaling using a gamma secretase inhibitor, RO4929097, in an in vitro model that enriches for cancer initiating cells (3D clonogenic assay) and conventional 2D clonogenic assay to compare the effect on radiosensitization of the SUM149 and SUM190 IBC cell lines. RO4929097 downregulated the Notch target genes Hes1, Hey1, and HeyL, and showed a significant reduction in anchorage independent growth in SUM190 and SUM149. However, the putative self-renewal assay mammosphere formation efficiency was increased with the drug. To assess radiosensitization of putative cancer stem cells, cells were exposed to increasing doses of radiation with or without 1 μM RO4929097 in their standard (2D) and self-renewal enriching (3D) culture conditions. In the conventional 2D clonogenic assay, RO4929097 significantly sensitized SUM190 cells to ionizing radiation and has a modest radiosensitization effect in SUM149 cells. In the 3D clonogenic assays, however, a radioprotective effect was seen in both SUM149 and SUM190 cells at higher doses. Both cell lines express IL-6 and IL-8 cytokines known to mediate the efficacy of Notch inhibition and to promote self-renewal of stem cells. We further showed that RO429097 inhibits normal T-cell synthesis of some inflammatory cytokines, including TNF-α, a potential mediator of IL-6 and IL-8 production in the microenvironment. These data suggest that additional targeting agents may be required to selectively target IBC stem cells through Notch inhibition, and that evaluation of microenvironmental influences may shed further light on the potential effects of this inhibitor.

  11. Transiting exoplanets from the CoRoT space mission. XI. CoRoT-8b: a hot and dense sub-Saturn around a K1 dwarf

    CERN Document Server

    Bordé, P; Deleuil, M; Cabrera, J; Jorda, L; Lovis, C; Csizmadia, S; Aigrain, S; Almenara, J M; Alonso, R; Auvergne, M; Baglin, A; Barge, P; Benz, W; Bonomo, A S; Bruntt, H; Carone, L; Carpano, S; Deeg, H; Dvorak, R; Erikson, A; Ferraz-Mello, S; Fridlund, M; Gandolfi, D; Gazzano, J -C; Gillon, M; Guenther, E; Guillot, T; Guterman, P; Hatzes, A; Havel, M; Hébrard, G; Lammer, H; Léger, A; Mayor, M; Mazeh, T; Moutou, C; Pätzold, M; Pepe, F; Ollivier, M; Queloz, D; Rauer, H; Rouan, D; Samuel, B; Santerne, A; Schneider, J; Tingley, B; Udry, S; Weingrill, J; Wuchterl, G

    2010-01-01

    We report the discovery of CoRoT-8b, a dense small Saturn-class exoplanet that orbits a K1 dwarf in 6.2 days, and we derive its orbital parameters, mass, and radius. We analyzed two complementary data sets: the photometric transit curve of CoRoT-8b as measured by CoRoT and the radial velocity curve of CoRoT-8 as measured by the HARPS spectrometer. We find that CoRoT-8b is on a circular orbit with a semi-major axis of 0.063 +/- 0.001 AU. It has a radius of 0.57 +/- 0.02 RJ, a mass of 0.22 +/- 0.03 MJ, and therefore a mean density 1.6 +/- 0.1 g/cm^3. With 67 % of the size of Saturn and 72 % of its mass, CoRoT-8b has a density comparable to that of Neptune (1.76 g/cm^3). We estimate its content in heavy elements to be 47-63 Earth masses, and the mass of its hydrogen-helium envelope to be 7-23 Earth masses. At 0.063 AU, the thermal loss of hydrogen of CoRoT-8b should be no more than about 0.1 % over an assumed integrated lifetime of 3~Ga.

  12. Business Ethics in Third World Countries. A Romanian Representative Case: Roşia Montană

    Directory of Open Access Journals (Sweden)

    Iuliana Zaharia

    2010-03-01

    Full Text Available

    Roşia Montană case became representative by its complexity, considering the interaction of the economic with other social sectors on one hand, and on the other hand, considering the context of a economy on the globalization edge in a South-eastern European country 'rebuilt' after 1989 and in a permanent 'reform' of 20 years, representative by the way the economics dictates to the politics, sealing the road to sustainable disaster in an "era of sustainable development”. Edifying symbol of the times that we live at the beginning of the XXIst century, maintaing the focus on the Romanian opened wound Roşia Montană is equivalent to a live lesson about the survival or the collapse of the (human ecosystem. About the morality as a reality of another order than that of biological life and as a sine qua non condition of the humanity preservation.

    Note: The aggregate term Third World was challenged as misleading starting with the Cold War period, because it got various meanings depending on different points of view: 1. it was used to define during the Cold War the countries that remained non-aligned or not moving at all with either capitalism and NATO (which along with its allies represented the First World or communism and the Soviet Union (which along with its allies represented the Second World; 2. it has also a completely different definition according to human development index – the term Third World, when used today generally denotes countries that have not "developed" to the same levels as OECD countries, and which are thus in the process of "developing"; 3. in the 1980s, economist Peter Bauer offered a competing definition for the term Third World, claiming that the attachment of Third World status to a particular country was not based on any stable economic or political criteria, and was a mostly arbitrary process. The large diversity of countries that were considered to be part of the Third World, from Indonesia to Afghanistan

  13. Business Ethics in Third World Countries. A Romanian Representative Case: Roşia Montană

    Directory of Open Access Journals (Sweden)

    Iuliana Zaharia

    2010-03-01

    Full Text Available Roşia Montană case became representative by its complexity, considering the interaction of the economic with other social sectors on one hand, and on the other hand, considering the context of a economy on the globalization edge in a South-eastern European country 'rebuilt' after 1989 and in a permanent 'reform' of 20 years, representative by the way the economics dictates to the politics, sealing the road to sustainable disaster in an "era of sustainable development”. Edifying symbol of the times that we live at the beginning of the XXIst century, maintaing the focus on the Romanian opened wound Roşia Montană is equivalent to a live lesson about the survival or the collapse of the (human ecosystem. About the morality as a reality of another order than that of biological life and as a sine qua non condition of the humanity preservation.Note: The aggregate term Third World was challenged as misleading starting with the Cold War period, because it got various meanings depending on different points of view: 1. it was used to define during the Cold War the countries that remained non-aligned or not moving at all with either capitalism and NATO (which along with its allies represented the First World or communism and the Soviet Union (which along with its allies represented the Second World; 2. it has also a completely different definition according to human development index – the term Third World, when used today generally denotes countries that have not "developed" to the same levels as OECD countries, and which are thus in the process of "developing"; 3. in the 1980s, economist Peter Bauer offered a competing definition for the term Third World, claiming that the attachment of Third World status to a particular country was not based on any stable economic or political criteria, and was a mostly arbitrary process. The large diversity of countries that were considered to be part of the Third World, from Indonesia to Afghanistan, ranged

  14. Transiting exoplanets from the CoRoT space mission: XIII. CoRoT-14b: an unusually dense very hot Jupiter

    CERN Document Server

    Tingley, B; Gazzano, J -C; Alonso, R; Mazeh, T; Jorda, L; Aigrain, S; Almenara, J -M; Auvergne, M; Baglin, A; Barge, P; Bonomo, A S; Bordé, P; Bouchy, F; Bruntt, H; Cabrera, J; Carpano, S; Carone, L; Cochran, W D; Csizmadia, Sz; Deleuil, M; Deeg, H J; Dvorak, R; Erikson, A; Ferraz-Mello, S; Fridlund, M; Gandolfi, D; Gillon, M; Guenther, E W; Guillot, T; Hatzes, A; Hébrard, G; Léger, A; Llebaria, A; Lammer, H; Lovis, C; MacQueen, P J; Moutou, C; Ollivier, M; Ofir, A; Pätzold, M; Pepe, F; Queloz, D; Rauer, H; Rouan, D; Samuel, B; Schneider, J; Shporer, A; Wuchterl, G

    2011-01-01

    In this paper, the CoRoT Exoplanet Science Team announces its 14th discovery. Herein, we discuss the observations and analyses that allowed us to derive the parameters of this system: a hot Jupiter with a mass of $7.6 \\pm 0.6$ Jupiter masses orbiting a solar-type star (F9V) with a period of only 1.5 d, less than 5 stellar radii from its parent star. It is unusual for such a massive planet to have such a small orbit: only one other known exoplanet with a higher mass orbits with a shorter period.

  15. Ro-52抗体在自身免疫性肝病中的检测%Antibody to Ro-52 in patients with autoimmune liver disease

    Institute of Scientific and Technical Information of China (English)

    赵丹彤; 闫惠平; 檀玉芬; 刘妍; 赵艳; 冯霞; 向代军

    2009-01-01

    Objective To investigate the significance of antibody to Ro-52 in patients with autoim-mune liver disease(AILD). Methods One hundred and fifteen patients with abnormal liver functions, who had anti-Ro-52 detection by immunological blotting, were reviewed retrospectively. According to types of AILD, the clinical features were compared between patients with and without anti-Ro-52, respectively, κ test of concordance was used to provide a chance-corrected valve for immune-serological results. Results The rates of anti-Ro-52 in autoimmune hepatitis( AIH), primary sclerosing cholangitis(PBC) and AIH/PBC o-verlap syndrome groups were 32.43%, 24.56% and 33.33%, respectively, there were no significant differ-enees among three groups ( x2 = 0. 949, P >0. 05). The rate of anti-soluble hver antigen/liver-pancreas ( an-ti-SLA/LP) in AIH patients with anti-Ro-52 (58.33%) was higher than AIH patients without anti-Ro-52 ( 16.00% ,P 0.40, P 0.05).抗可溶性肝抗原/肝胰抗原抗体(anti-soluble liver antigen/liver-pancreas,anti-SLA/LP)在抗Ro-52阳性AIH组频率(58.33%)高于阴性组(16.00%)(x2=6.955,P<0.05),抗SLA/LP抗体在抗R0-52阳性AIH/PBC重叠综合征组频率(85.71%)高于阴性组(28.57%)(x2=6.109,P<0.05).抗Ro-52抗体和抗SLA/LP抗体结果有一致性(κ=0.466,P<0.05).AIH/PBC重叠综合征组抗Ro-52阳性患者IgG水平高于阴性患者(t=2.508,P<0.05).结论 抗Ro-52抗体在AIH、PBC和MH/PBC重叠综合征中的分布没有差别;抗Ro-52抗体与抗SLA/LP抗体检测结果有一致性;抗Ro-52抗体阳性MH/PBC重叠综合征患者IgG水平高于抗体阴性者.

  16. Secondary eclipses in the CoRoT light curves: A homogeneous search based on Bayesian model selection

    CERN Document Server

    Parviainen, Hannu; Belmonte, Juan Antonio

    2012-01-01

    We aim to identify and characterize secondary eclipses in the original light curves of all published CoRoT planets using uniform detection and evaluation critetia. Our analysis is based on a Bayesian model selection between two competing models: one with and one without an eclipse signal. The search is carried out by mapping the Bayes factor in favor of the eclipse model as a function of the eclipse center time, after which the characterization of plausible eclipse candidates is done by estimating the posterior distributions of the eclipse model parameters using Markov Chain Monte Carlo. We discover statistically significant eclipse events for two planets, CoRoT-6b and CoRoT-11b, and for one brown dwarf, CoRoT-15b. We also find marginally significant eclipse events passing our plausibility criteria for CoRoT-3b, 13b, 18b, and 21b. The previously published CoRoT-1b and CoRoT-2b eclipses are also confirmed.

  17. Non-coding roX RNAs prevent the binding of the MSL-complex to heterochromatic regions.

    Directory of Open Access Journals (Sweden)

    Margarida L A Figueiredo

    2014-12-01

    Full Text Available Long non-coding RNAs contribute to dosage compensation in both mammals and Drosophila by inducing changes in the chromatin structure of the X-chromosome. In Drosophila melanogaster, roX1 and roX2 are long non-coding RNAs that together with proteins form the male-specific lethal (MSL complex, which coats the entire male X-chromosome and mediates dosage compensation by increasing its transcriptional output. Studies on polytene chromosomes have demonstrated that when both roX1 and roX2 are absent, the MSL-complex becomes less abundant on the male X-chromosome and is relocated to the chromocenter and the 4th chromosome. Here we address the role of roX RNAs in MSL-complex targeting and the evolution of dosage compensation in Drosophila. We performed ChIP-seq experiments which showed that MSL-complex recruitment to high affinity sites (HAS on the X-chromosome is independent of roX and that the HAS sequence motif is conserved in D. simulans. Additionally, a complete and enzymatically active MSL-complex is recruited to six specific genes on the 4th chromosome. Interestingly, our sequence analysis showed that in the absence of roX RNAs, the MSL-complex has an affinity for regions enriched in Hoppel transposable elements and repeats in general. We hypothesize that roX mutants reveal the ancient targeting of the MSL-complex and propose that the role of roX RNAs is to prevent the binding of the MSL-complex to heterochromatin.

  18. Limits to the presence of transiting circumbinary planets in CoRoT Data

    Science.gov (United States)

    Klagyivik, P.; Deeg, H. J.; Cabrera, J.; Csizmadia, Sz.; Almenara, J. M.

    2017-06-01

    Aims: During its flight phase, from 2007-2012, the CoRoT mission delivered light curves for over 2000 eclipsing binaries. Data from the Kepler mission have proven the existence of several transiting circumbinary planets. While light curves from CoRoT typically have lower precision and shorter coverage, the number of CoRoT targets is similar to that of Kepler and some of the known circumbinary planets could potentially be detected in CoRoT data as well. The aim of this work was to reanalyse the entire CoRoT Data set to search for the presence of circumbinary planets and to derive limits on the abundances of such planets. Methods: We developed a code that removes the signatures of eclipsing binaries from the light curves, and searches for quasi-periodic, transit-like features in the light curves after removal of binary eclipses and instrumental features. The code requires little information on sample systems and can also be used for other space missions, such as Kepler, K2, TESS, and PLATO. The code is broad in the requirements leading to detections, but was tuned to deliver an amount of detections that are manageable in a subsequent, mainly visual, assessment of their origin. Results: We identified three planet candidates in the CoRoT sample whose transits would have arisen from a single pass across the central binary; however, no candidates with transit events from multiple planetary orbits remained. We calculated the upper limits for the number of Jupiter, Saturn-, and Neptune-sized planets in co-planar orbits for different orbital period ranges. We found that there are much fewer giant planets in short periodic orbits around close binary systems than around single stars. Full Table 1 is only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/602/A117

  19. Measurements of OH and RO2 radicals at Dome C, East Antarctica

    Directory of Open Access Journals (Sweden)

    A. Kukui

    2014-06-01

    Full Text Available Concentrations of OH radicals and the sum of peroxy radicals, RO2, were measured in the boundary layer for the first time on the East Antarctic Plateau at the Concordia Station (Dome C, 75.10° S, 123.31° E during the austral summer 2011/2012. The median concentrations of OH and RO2 radicals were 3.1 × 106 molecule cm−3 and 9.9 × 107 molecule cm−3, respectively. These values are comparable to those observed at the South Pole, confirming that the elevated oxidative capacity of the Antarctic atmospheric boundary layer found at the South Pole is not restricted to the South Pole but common over the high Antarctic plateau. At Concordia, the concentration of radicals showed distinct diurnal profiles with the median maximum of 5.2 × 106 molecule cm−3 at 11:00 and the median minimum of 1.1 × 106 molecule cm−3 at 01:00 for OH radicals and 1.7 × 108 molecule cm−3 and 2.5 × 107 molecule cm−3 for RO2 radicals at 13:00 and 23:00, respectively (all times are local times. Concurrent measurements of O3, HONO, NO, NO2, HCHO and H2O2 demonstrated that the major primary source of OH and RO2 radicals at Dome C was the photolysis of HONO, HCHO and H2O2, with the photolysis of HONO contributing ∼75% of total primary radical production. However, photochemical modelling with accounting for all these radical sources overestimates the concentrations of OH and RO2 radicals by a factor of 2 compared to field observations. Neglecting the OH production from HONO in the photochemical modelling results in an underestimation of the concentrations of OH and RO2 radicals by a factor of 2. To explain the observations of radicals in this case an additional source of OH equivalent to about 25% of measured photolysis of HONO is required. Even with a factor of 4 reduction in the concentrations of HONO, the photolysis of HONO represents the major primary radical source at Dome C. Another major factor leading to the large concentration of OH radicals measured at

  20. Understanding nuclear motions in molecules: Derivation of Eckart frame ro-vibrational Hamiltonian operators via a gateway Hamiltonian operator.

    Science.gov (United States)

    Szalay, Viktor

    2015-05-07

    A new ro-vibrational Hamiltonian operator, named gateway Hamiltonian operator, with exact kinetic energy term, Tˆ, is presented. It is in the Eckart frame and it is of the same form as Watson's normal coordinate Hamiltonian. However, the vibrational coordinates employed are not normal coordinates. The new Hamiltonian is shown to provide easy access to Eckart frame ro-vibrational Hamiltonians with exact Tˆ given in terms of any desired set of vibrational coordinates. A general expression of the Eckart frame ro-vibrational Hamiltonian operator is given and some of its properties are discussed.

  1. Transiting exoplanets from the CoRoT space mission - XIX. CoRoT-23b: a dense hot Jupiter on an eccentric orbit

    CERN Document Server

    Rouan, D; Moutou, C; Deleuil, M; Fridlund, M; Ofir, A; Havel, M; Aigrain, S; Alonso, R; Auvergne, M; Baglin, A; Barge, P; Bonomo, A; Bordé, P; Bouchy, F; Cabrera, J; Cavarroc, C; Csizmadia, Sz; Deeg, H; Diaz, R F; Dvorak, R; Erikson, A; Ferraz-Mello, S; Gandolfi, D; Gillon, M; Guillot, T; Hatzes, A; Hébrard, G; Jorda, L; Léger, A; Llebaria, A; Lammer, H; Lovis, C; Mazeh, T; Ollivier, M; Pätzold, M; Queloz, D; Rauer, H; Samuel, B; Santerne, A; Schneider, J; Tingley, B; Wuchterl, G

    2011-01-01

    We report the detection of CoRoT-23b, a hot Jupiter transiting in front of its host star with a period of 3.6314 \\pm 0.0001 days. This planet was discovered thanks to photometric data secured with the CoRoT satellite, combined with spectroscopic radial velocity (RV) measurements. A photometric search for possible background eclipsing binaries conducted at CFHT and OGS concluded with a very low risk of false positives. The usual techniques of combining RV and transit data simultaneously were used to derive stellar and planetary parameters. The planet has a mass of Mp = 2.8 \\pm 0.3 MJup, a radius of Rpl = 1.05 \\pm 0.13 RJup, a density of \\approx 3 g cm-3. RV data also clearly reveal a non zero eccentricity of e = 0.16 \\pm 0.02. The planet orbits a mature G0 main sequence star of V =15.5 mag, with a mass M\\star = 1.14 \\pm 0.08 M\\odot, a radius R\\star = 1. 61 \\pm 0.18 R\\odot and quasi-solar abundances. The age of the system is evaluated to be 7 Gyr, not far from the transition to subgiant, in agreement with the r...

  2. MSF/RO/ED海水淡化技术研究%The General Conditions of MSF/RO/ED in Seawater Desalination Technology

    Institute of Scientific and Technical Information of China (English)

    李志敏; 曾秋苑; 李淳; 敖宁建

    2012-01-01

    综述了世界水资源形势以及海水淡化技术的发展现状,概括了海水淡化技术的主要方法,着重介绍了多级闪蒸海水淡化法(MSF)、反渗透法(RO)和电渗析法(ED),从各种装置的组件、能耗以及淡化过程等入手,总结3种方法的优势与不足,针对性提出了解决问题的方法以及发展方向,以降低使用成本,并探讨和展望了今后的海水淡化技术.%The situation of water resources in the whole world and the development of seawater desalination technology are summarized, various methods of water desalination technology are generalized. It emphasizes the method of multi-stage flash (MSF) distillation, the method of reverse osmosis (RO), and electrodialysis method(ED), through the components and energy consumption of all equipments and the process of seawater desalination to summarize the advantages and disadvantages of these methods. And the solutions of these disadvantages and its development direction to reduce the cost are proposed. Seawater desalination technology for the future are also discussed and prospected.

  3. Transiting exoplanets from the CoRoT space mission. XX. CoRoT-18b: a massive hot jupiter on a prograde, nearly aligned orbit

    CERN Document Server

    Hebrard, G; Alonso, R; Fridlund, M; Ofir, A; Aigrain, S; Guillot, T; Almenara, J M; Auvergne, M; Baglin, A; Barge, P; Bonomo, A S; Borde, P; Bouchy, F; Cabrera, J; Carone, L; Carpano, S; Cavarroc, C; Csizmadia, Sz; Deeg, H J; Deleuil, M; Diaz, R F; Dvorak, R; Erikson, A; Ferraz-Mello, S; Gandolfi, D; Gibson, N; Gillon, M; Guenther, E; Hatzes, A; Havel, M; Jorda, L; Lammer, H; Leger, A; Llebaria, A; Mazeh, T; Moutou, C; Ollivier, M; Parviainen, H; Patzold, M; Queloz, D; Rauer, H; Rouan, D; Santerne, A; Schneider, J; Tingley, B; Wuchterl, G

    2011-01-01

    We report the detection of CoRoT-18b, a massive hot jupiter transiting in front of its host star with a period of 1.9000693 +/- 0.0000028 days. This planet was discovered thanks to photometric data secured with the CoRoT satellite combined with spectroscopic and photometric follow-up ground-based observations. The planet has a mass M_p = 3.47 +/- 0.38 M_Jup, a radius R_p = 1.31 +/- 0.18 R_Jup, and a density rho_p = 2.2 +/- 0.8 g/cm3. It orbits a G9V star with a mass M_* = 0.95 +/- 0.15 M_Sun, a radius R_* = 1.00 +/- 0.13 R_Sun, and a rotation period P_rot = 5.4 +/- 0.4 days. The age of the system remains uncertain, stellar evolution models pointing either to a few tens Ma or several Ga, while gyrochronology and lithium abundance point towards ages of a few hundred Ma. This mismatch potentially points to a problem in our understanding of the evolution of young stars, with possible significant implications for stellar physics and the interpretation of inferred sizes of exoplanets around young stars. We detected...

  4. Transiting exoplanets from the CoRoT space mission: XXIV. CoRoT-24: A transiting multi-planet system

    CERN Document Server

    Alonso, R; Endl, M; Almenara, J M; Guenther, E W; Deleuil, M; Hatzes, A; Aigrain, S; Auvergne, M; Baglin, A; Barge, P; Bonomo, A S; Bordé, P; Bouchy, F; Cavarroc, C; Cabrera, J; Carpano, S; Csizmadia, Sz; Cochran, W D; Deeg, H J; Díaz, R F; Dvorak, R; Erikson, A; Ferraz-Mello, S; Fridlund, M; Fruth, T; Gandolfi, D; Gillon, M; Grziwa, S; Guillot, T; Hébrard, G; Jorda, L; Léger, A; Lammer, H; Lovis, C; MacQueen, P J; Mazeh, T; Ofir, A; Ollivier, M; Pasternacki, T; Patzold, M; Queloz, D; Rauer, H; Rouan, D; Santerne, A; Schneider, J; Santos, M Tadeu dos; Tingley, B; Titz-Weider, R; Weingrill, J; Wuchterl, G

    2014-01-01

    We present the discovery of a candidate multiply-transiting system, the first one found in the CoRoT mission. Two transit-like features with periods of 5.11 and 11.76d are detected in the CoRoT light curve, around a main sequence K1V star of r=15.1. If the features are due to transiting planets around the same star, these would correspond to objects of 3.7$\\pm$0.4 and 5.0$\\pm$0.5 R_earth respectively. Several radial velocities serve to provide an upper limit of 5.7 M_earth for the 5.11~d signal, and to tentatively measure a mass of 28$^{+11}_{-11}$ M_earth for the object transiting with a 11.76~d period. These measurements imply low density objects, with a significant gaseous envelope. The detailed analysis of the photometric and spectroscopic data serve to estimate the probability that the observations are caused by transiting Neptune-sized planets as $>$26$\\times$ higher than a blend scenario involving only one transiting planet, and $>$900$\\times$ higher than a scenario involving two blends and no planets....

  5. BEER analysis of Kepler and CoRoT light curves. III. Spectroscopic confirmation of seventy new beaming binaries discovered in CoRoT light curves

    Science.gov (United States)

    Tal-Or, L.; Faigler, S.; Mazeh, T.

    2015-08-01

    Context. The BEER algorithm searches stellar light curves for the BEaming, Ellipsoidal, and Reflection photometric modulations that are caused by a short-period companion. These three effects are typically of very low amplitude and can mainly be detected in light curves from space-based photometers. Unlike eclipsing binaries, these effects are not limited to edge-on inclinations. Aims: Applying the algorithm to wide-field photometric surveys such as CoRoT and Kepler offers an opportunity to better understand the statistical properties of short-period binaries. It also widens the window for detecting intrinsically rare systems, such as short-period brown-dwarf and massive-planetary companions to main-sequence stars. Methods: Applying the search to the first five long-run center CoRoT fields, we identified 481 non-eclipsing candidates with periodic flux amplitudes of 0.5-87 mmag. Optimizing the Anglo-Australian-Telescope pointing coordinates and the AAOmega fiber-allocations with dedicated softwares, we acquired six spectra for 231 candidates and seven spectra for another 50 candidates in a seven-night campaign. Analysis of the red-arm AAOmega spectra, which covered the range of 8342-8842 Å, yielded a radial-velocity precision of ~1 km s-1. Spectra containing lines of more than one star were analyzed with the two-dimensional correlation algorithm TODCOR. Results: The measured radial velocities confirmed the binarity of seventy of the BEER candidates - 45 single-line binaries, 18 double-line binaries, and 7 diluted binaries. We show that red giants introduce a major source of false candidates and demonstrate a way to improve BEER's performance in extracting higher fidelity samples from future searches of CoRoT light curves. The periods of the confirmed binaries span a range of 0.3-10 days and show a rise in the number of binaries per ΔlogP toward longer periods. The estimated mass ratios of the double-line binaries and the mass ratios assigned to the single

  6. Exposure-based Algorithm for Removing Systematics out of the CoRoT Light Curves

    CERN Document Server

    Guterman, P; Faigler, S

    2015-01-01

    The CoRoT space mission was operating for almost 6 years, producing thousands of continuous photometric light curves. The temporal series of exposures are processed by the production pipeline, correcting the data for known instrumental effects. But even after these model-based corrections, some collective trends are still visible in the light curves. We propose here a simple exposure-based algorithm to remove instrumental effects. The effect of each exposure is a function of only two instrumental stellar parameters, position on the CCD and photometric aperture. The effect is not a function of the stellar flux, and therefore much more robust. As an example, we show that the $\\sim2\\%$ long-term variation of the early run LRc01 is nicely detrended on average. This systematics removal process is part of the CoRoT legacy data pipeline.

  7. CoRoT observations of O stars: diverse origins of variability

    CERN Document Server

    Blomme, R; Degroote, P; Mahy, L; Aerts, C; Cuypers, J; Godart, M; Gosset, E; Hareter, M; Montalban, J; Morel, T; Nieva, M F; Noels, A; Oreiro, R; Poretti, E; Przybilla, N; Rainer, M; Rauw, G; Schiller, F; Simon-Diaz, S; Smolders, K; Ventura, P; Vuckovic, M; Auvergne, M; Baglin, A; Baudin, F; Catala, C; Michel, E; Samadi, R

    2011-01-01

    Six O-type stars were observed continuously by the CoRoT satellite during a 34.3-day run. The unprecedented quality of the data allows us to detect even low-amplitude stellar pulsations in some of these stars (HD 46202 and the binaries HD 46149 and Plaskett's star). These cover both opacity-driven modes and solar-like stochastic oscillations, both of importance to the asteroseismological modelling of O stars. Additional effects can be seen in the CoRoT light curves, such as binarity and rotational modulation. Some of the hottest O-type stars (HD 46223, HD 46150 and HD 46966) are dominated by the presence of red-noise: we speculate that this is related to a sub-surface convection zone.

  8. VLT transit and occultation photometry for the bloated planet CoRoT-1b

    CERN Document Server

    Gillon, M; Triaud, A H M J; Barman, T; Hebb, L; Montalban, J; Maxted, P F L; Queloz, D; Deleuil, M; Magain, P

    2009-01-01

    We present VLT eclipse photometry for the giant planet CoRoT-1b. We observed a transit in the R-band filter and an occultation in a narrow filter centered on 2.09 microns. Our analysis of this new photometry and published radial velocities, in combination with stellar-evolutionary modeling, leads to a planetary mass and radius of 1.07 (+0.13,-0.18) M_Jup and 1.45 (+0.07,-0.13) R_Jup, confirming the very low density previously deduced from CoRoT photometry. The large occultation depth that we measure at 2.09 microns (0.278 (+0.043,-0.066) %) is consistent with thermal emission and is better reproduced by an atmospheric model with no redistribution of the absorbed stellar flux to the night side of the planet.

  9. Dinâmica evolutiva em roças de caboclos amazônicos

    Directory of Open Access Journals (Sweden)

    Paulo Sodero Martins

    2005-04-01

    Full Text Available AS ROÇAS DE CABOCLOS são unidades de agricultura de derruba e queima de populações tradicionais nas terras firmes dos trópicos brasileiros, geralmente associados com florestas. Elas são derivadas de sistemas indígenas com algumas modificações introduzidas pelos africanos e portugueses. Neste trabalho, analisamos a estrutura de comunidade dessas roças e o papel dos fatores biológicos e culturais em manter e aumentar a variabilidade genética na mais importante espécie plantada nas roças, a mandioca (Manihot esculenta. Há um alto grau de diversidade nas roças e muitas espécies que estão normalmente presentes, como mandioca, batata-doce, inhame, ariá, araruta, cupá, amendoim, apresentam o que tem sido chamado de habilidade de combinação ecológica, o que significa que elas otimizam o uso dos fatores ambientais e recursos, minimizando a sobreposição de suas arquiteturas. A variabilidade de mandioca é ampliada pelo banco de sementes em ��reas previamente ocupadas, cruzamentos interespecíficos e intervarietais, facilitada pelo arranjo das plantações escolhido pelos caboclos. Depois de criada, a variabilidade é fixada através de clonagem vegetativa, o método de reprodução comum não apenas da mandioca, mas também de outras espécies da roça, a maioria perene e apresentando "disjunção agronômica", ou seja, reprodução e produção efetivada por diferentes órgãos da planta.THE "ROÇAS DE CABOCLOS" are the slash-and-burn agricultural units of traditional populations dwelling in the lowlands of the Brazilian Tropics, generally in association with forests. They are derived from the indigenous system with some modifications introduced by the Africans and Portuguese. In this paper we analyse the community structure of the "roças" and the role of biological and cultural factors in maintaining and augmenting the genetic variability in the most important species planted in roças, the cassava (Manihot esculenta. There

  10. A self consistent chemically stratified atmosphere model for the roAp star 10 Aquilae

    CERN Document Server

    Nesvacil, Nicole; Ryabchikova, Tanya A; Kochukhov, Oleg; Akberov, Artur; Weiss, Werner W

    2012-01-01

    Context: Chemically peculiar A type (Ap) stars are a subgroup of the CP2 stars which exhibit anomalous overabundances of numerous elements, e.g. Fe, Cr, Sr and rare earth elements. The pulsating subgroup of the Ap stars, the roAp stars, present ideal laboratories to observe and model pulsational signatures as well as the interplay of the pulsations with strong magnetic fields and vertical abundance gradients. Aims: Based on high resolution spectroscopic observations and observed stellar energy distributions we construct a self consistent model atmosphere, that accounts for modulations of the temperature-pressure structure caused by vertical abundance gradients, for the roAp star 10 Aquilae (HD 176232). We demonstrate that such an analysis can be used to determine precisely the fundamental atmospheric parameters required for pulsation modelling. Methods: Average abundances were derived for 56 species. For Mg, Si, Ca, Cr, Fe, Co, Sr, Pr, and Nd vertical stratification profiles were empirically derived using the...

  11. ASTRO APEx(®) and RO-ILS™ are applicable to medical malpractice in radiation oncology.

    Science.gov (United States)

    Zaorsky, Nicholas G; Ricco, Anthony G; Churilla, Thomas M; Horwitz, Eric M; Den, Robert B

    2016-11-01

    To analyze malpractice trials in radiation oncology and assess how ASTRO APEx(®) and RO-ILS™ apply to such cases. The Westlaw database was reviewed using PICOS/PRISMA methods. Fisher's exact and Mann-Whitney U tests were used to find factors associated with outcomes. Of 34 cases identified, external beam was used in 26 (77%). The most common factors behind malpractice were excessive toxicity (80%) and lack of informed consent (66%). ASTRO APEx pillars and ROI-LS had applicability to all but one case. Factors favoring the defendant included statute of limitations (odds ratio: 8.1; 95% CI: 1.3-50); those favoring the plaintiff included patient death (odds ratio: 0.7; 95% CI: 0.54-0.94). APEx and RO-ILS are applicable to malpractice trials in radiation oncology.

  12. Neonatal molecular pathologies induced by maternal anti-Ro and anti-La antibodies

    Directory of Open Access Journals (Sweden)

    Herrera-Esparza R

    2015-08-01

    Full Text Available Maternal antinuclear antibodies with anti-Ro or anti-La specificity might be pathogenic to the fetus and could induce molecular neonatal pathologies, such as neonatal lupus (NL with or without congenital heart block (CHB. The cutaneous manifestations of neonatal lupus appear at birth or a few weeks later, and skin lesions may persist for weeks. While CHB is characterized by intrauterine bradycardia or low heart rates at birth and may persist for months, depending on the degree of blockage. Clinical and experimental data demonstrated that anti-Ro and anti-La autoantibodies functionally inhibit L-type calcium channels and induce abnormalities in electrical conduction of the cardiac myocytes. It has been 38 years since the first clinical description of CHB. Presently, the pathophysiology of CHB has been clarified through clinical and basic research studies.

  13. The SARS algorithm: detrending CoRoT light curves with Sysrem using simultaneous external parameters

    CERN Document Server

    Ofir, Aviv; Bonomo, Aldo Stefano; Carone, Ludmila; Carpano, Stefania; Samuel, Benjamin; Weingrill, Jorg; Aigrain, Suzanne; Auvergne, Michel; Baglin, Annie; Barge, Pierre; Borde, Pascal; Bouchy, Francois; Deeg, Hans J; Deleuil, Magali; Dvorak, Rudolf; Erikson, Anders; Mello, Sylvio Ferraz; Fridlund, Malcolm; Gillon, Michel; Guillot, Tristan; Hatzes, Artie; Jorda, Laurent; Lammer, Helmut; Leger, Alain; Llebaria, Antoine; Moutou, Claire; Ollivier, Marc; Paetzold, Martin; Queloz, Didier; Rauer, Heike; Rouan, Daniel; Schneider, Jean; Wuchterl, Guenther

    2010-01-01

    Surveys for exoplanetary transits are usually limited not by photon noise but rather by the amount of red noise in their data. In particular, although the CoRoT spacebased survey data are being carefully scrutinized, significant new sources of systematic noises are still being discovered. Recently, a magnitude-dependant systematic effect was discovered in the CoRoT data by Mazeh & Guterman et al. and a phenomenological correction was proposed. Here we tie the observed effect a particular type of effect, and in the process generalize the popular Sysrem algorithm to include external parameters in a simultaneous solution with the unknown effects. We show that a post-processing scheme based on this algorithm performs well and indeed allows for the detection of new transit-like signals that were not previously detected.

  14. AST\\/RO A Small Submillimeter Telescope at the South Pole

    CERN Document Server

    Stark, A A

    2001-01-01

    Understanding of star formation in the Universe is advancing through submillimeter-wave observations of the Milky Way and other galaxies. Technological constraints on such observations require a mixture of telescope sizes and observational techniques. For some purposes, small submillimeter-wave telescopes are more sensitive than large ones. The Antarctic Submillimeter Telescope and Remote Observatory (AST/RO) is a small, wide-field instrument located at an excellent observatory site. By observing the Milky Way and Magellanic Clouds at arcminute resolution, it provides a context for interpreting observations of distant galaxies made by large interferometric telescopes. AST/RO also provides hands-on training in submillimeter technology and allows testing of novel detector systems.

  15. Self protection from anti-viral responses--Ro52 promotes degradation of the transcription factor IRF7 downstream of the viral Toll-Like receptors.

    LENUS (Irish Health Repository)

    Higgs, Rowan

    2010-01-01

    Ro52 is a member of the TRIM family of single-protein E3 ligases and is also a target for autoantibody production in systemic lupus erythematosus and Sjögren\\'s syndrome. We previously demonstrated a novel function of Ro52 in the ubiquitination and proteasomal degradation of IRF3 following TLR3\\/4 stimulation. We now present evidence that Ro52 has a similar role in regulating the stability and activity of IRF7. Endogenous immunoprecipitation of Ro52-bound proteins revealed that IRF7 associates with Ro52, an effect which increases following TLR7 and TLR9 stimulation, suggesting that Ro52 interacts with IRF7 post-pathogen recognition. Furthermore, we show that Ro52 ubiquitinates IRF7 in a dose-dependent manner, resulting in a decrease in total IRF7 expression and a subsequent decrease in IFN-alpha production. IRF7 stability was increased in bone marrow-derived macrophages from Ro52-deficient mice stimulated with imiquimod or CpG-B, consistent with a role for Ro52 in the negative regulation of IRF7 signalling. Taken together, these results suggest that Ro52-mediated ubiquitination promotes the degradation of IRF7 following TLR7 and TLR9 stimulation. As Ro52 is known to be IFN-inducible, this system constitutes a negative-feedback loop that acts to protect the host from the prolonged activation of the immune response.

  16. Full-Scale Modal Analysis of a Ro-Lo Vessel in Operation

    DEFF Research Database (Denmark)

    Orlowitz, Esben

    Et skib udsættes for en kompleks vibration miljø, påvirket a have såvel som selve operationen af skibet. Særligt hydrodynamiske og -elastiske effekter er svære at bestemme teoretisk. Derfor er eksperimentelle resultater vigtige for verificering. I denne poster visses præliminære resultater fra en...... fuld skala modal test af et Ro-Lo skib....

  17. CoRoT and asteroseismology. Preparatory work and simultaneous ground-based monitoring

    CERN Document Server

    Poretti, Ennio; Uytterhoeven, Katrien; Cutispoto, Giuseppe; Distefano, Elisa; Romano, Paolo

    2007-01-01

    The successful launch of the CoRoT (COnvection, ROtation and planetary Transits) satellite opens a new era in asteroseismology. The space photometry is complemented by high-resolution spectroscopy and multicolour photometry from ground, to disclose the pulsational content of the asteroseismic targets in the most complete way. Some preliminary results obtained with both types of data are presented. The paper is based on observations collected at S. Pedro Martir, Serra La Nave, La Silla, and Telescopio Nazionale Galileo Observatories.

  18. EXTENDED CES(A)RO OPERATORS ON THE BLOCH SPACE IN THE UNIT BALL OF Cn

    Institute of Scientific and Technical Information of China (English)

    胡璋剑

    2003-01-01

    The paper defines an extended Cesàro operator Tg with holomorphic symbolg in the unit ball B of Cn asWhere g(z)= ∑j=1∑n zj g/ zj is the radial derivative of g. In this paper, the author characterizes g for which Tg is bounded (or compact) on the Bloch spaceB and the little Blochspace B0.

  19. Remission of congenital complete heart block without anti-Ro/La antibodies: A case report

    Directory of Open Access Journals (Sweden)

    Souvik Mitra

    2013-01-01

    Full Text Available Anti-Ro/La negative congenital heart block (CHB is uncommon. We report one such case of CHB, with no associated structural heart disease or maternal autoantibodies. The heart block reverted to sinus rhythm spontaneously at two weeks of age, and the patient remains in sinus rhythm at a one year followup. Whether patients with antibody negative complete heart block have a different clinical course is conjectural.

  20. Antiscalant removal in accelerated desupersaturation of RO concentrate via chemically-enhanced seeded precipitation (CESP).

    Science.gov (United States)

    McCool, Brian C; Rahardianto, Anditya; Cohen, Yoram

    2012-09-01

    An experimental study was carried out to demonstrate and quantify the feasibility of antiscalant (AS) removal from brackish water RO concentrate of high gypsum scaling propensity via lime treatment prior to seeded gypsum precipitation. Based on studies with model solutions, it was shown that sufficient AS removal (up to ∼90%) from RO concentrate is feasible via a lime treatment step (at a dose significantly lower than that required for conventional lime softening) to enable effective subsequent seeded gypsum precipitation. This two-step chemically-enhanced seeded precipitation (CESP) treatment of primary RO concentrate is suitable as an intermediate concentrate demineralization (ICD) stage for high recovery desalting employing secondary RO desalination. Analysis of gypsum precipitation and lime treatment kinetic data suggests that, after adequate CaCO(3) precipitation has been induced for effective AS scavenging, CaSO(4) desupersaturation can be achieved via seeded gypsum precipitation without retardation due to seed poisoning by AS. Also, the lime dose required to prevent seed poisoning during subsequent gypsum desupersaturation via seeded gypsum precipitation can be adequately assessed with a precipitation kinetics model that considers AS seed poisoning based on a Langmuir adsorption isotherm. The degree of AS removal after lime treatment increased linearly with the logarithm of the single lime dose additions. Staged lime dosing (i.e., multiple lime additions), however, removed a higher degree of AS relative to an equivalent single lime dose addition since a higher driving force for CaCO(3) precipitation could be maintained over the course of the lime treatment period.

  1. Remission of congenital complete heart block without anti-Ro/La antibodies: A case report.

    Science.gov (United States)

    Mitra, Souvik; Saha, Anindya Kumar; Sardar, Syamal Kumar; Singh, Arun Kumarendu

    2013-07-01

    Anti-Ro/La negative congenital heart block (CHB) is uncommon. We report one such case of CHB, with no associated structural heart disease or maternal autoantibodies. The heart block reverted to sinus rhythm spontaneously at two weeks of age, and the patient remains in sinus rhythm at a one year followup. Whether patients with antibody negative complete heart block have a different clinical course is conjectural.

  2. MEDICINAL HERBS USED BY CLIENTS ATTENDING CLINICAL UNITS OF SANTA MARCELINA, PORTO VELHO RO BRAZIL

    OpenAIRE

    Caetano, Rosemeiry Soares; FACULDADE SÃO LUCAS; de Souza, Ana Cristina Ramos; FACULDADE SÃO LUCAS; Feitoza, Leiliane Ferreira; FACULDADE SÃO LUCAS

    2014-01-01

    Many people are currently using medicinal herbs as a therapeutic alternative. Current paper tries to recover and analyze popular lore on the use of medicinal plants to cure diseases. Methodology consists of data collection by interviews with clients of clinical units of the Santa Marcelina Community in Porto Velho RO Brazil. Seventy-nine species and 46 botanic families were identified with special reference to Asteraceae and Lamiaceae with 10 and 8 species each. The most mentioned species wer...

  3. Raman investigation of ro-vibrational modes of interstitial H2 in Si

    Science.gov (United States)

    Koch, S. G.; Lavrov, E. V.; Weber, J.

    2012-08-01

    A Raman scattering study of ro-vibrational transitions Q(J) of the interstitial H2 in Si is presented. It is shown that the Q(2) mode of para hydrogen is coupled to the TAX phonon of Si. The mode appears in the spectra at temperatures above 200 K. The results presented also suggest that the Q(3) transition of ortho hydrogen is resonantly coupled to the OΓ phonon.

  4. Raman investigation of ro-vibrational modes of interstitial H{sub 2} in Si

    Energy Technology Data Exchange (ETDEWEB)

    Koch, S.G., E-mail: sandro.koch@physik.tu-dresden.de [Technische Universitaet Dresden, 01062 Dresden (Germany); Lavrov, E.V.; Weber, J. [Technische Universitaet Dresden, 01062 Dresden (Germany)

    2012-08-01

    A Raman scattering study of ro-vibrational transitions Q(J) of the interstitial H{sub 2} in Si is presented. It is shown that the Q(2) mode of para hydrogen is coupled to the TA{sub X} phonon of Si. The mode appears in the spectra at temperatures above 200 K. The results presented also suggest that the Q(3) transition of ortho hydrogen is resonantly coupled to the O{sub {Gamma}} phonon.

  5. Multiple dose study of the combined radiosensitizers Ro 03-8799 (pimonidazole) and SR 2508 (etanidazole)

    Energy Technology Data Exchange (ETDEWEB)

    Bleehen, N.M.; Newman, H.F.; Maughan, T.S.; Workman, P.

    1989-04-01

    The hypoxic cell radiosensitizers Ro 03-8799 and SR 2508 have different clinical toxicities. The former produces an acute but transient central nervous system syndrome, whereas the latter produces cumulative peripheral neuropathy. Following single dose studies, an escalating multiple dose schedule using both drugs in combination showed no unexpected adverse reactions at lower doses. This study identifies the clinical tolerance and pharmacokinetics when doses in the region of the maximal tolerated dose are given to 26 patients receiving infusions of 0.75 g/m2 Ro 03-8799 and 2 g/m2 SR 2508 three times per week. At 15 doses, 3/4 patients experienced WHO grade 2 peripheral neuropathy, whereas at 12 doses 1/9 developed grade 2 and 6/9 developed grade 1 neuropathies. This represents a lower dose of SR 2508 than can be given alone suggesting that some interaction between the two drugs does exist in terms of chronic peripheral neurotoxicity. Pharmacokinetic studies show no adverse interactions between the two drugs and minimal inter-patient variation. From bivariate analysis, cumulative AUC for Ro 03-8799 has the most significant correlation with the development of peripheral neuropathy. Tumor drug concentrations normalized to the administered dose show mean values of 34 micrograms/g Ro 03-8799 and 76 micrograms/g SR 2508 30 minutes after infusion. These could be expected to produce a single dose sensitizer enhancement ratio of 1.5. The combination of the two sensitizers at the maximum tolerable dose may be expected to give an increased therapeutic efficacy over either drug alone.

  6. An Analysis of the Propulsion Experiments Performed on a Model Representing the Stretched PONCE DE LEON (SPDL) Class RO/RO Ship Fitted with Two Sets of Design Contrarotating Propellers (Model 5362; Propellers 4731 & 4732 and 9019 & 9020).

    Science.gov (United States)

    1981-01-01

    REPRESENTING THE 5TRETCHED PONQ DE LEON (S.PI.) 9€ ASS _!"Q SHIP FITTED WITH TWO SETS OF DESIGN CONTRAROTATING PROPELLERS (MODEL 5362; PROPELLERS 4731...TYPE OF REPORT & PERIOD COVERED AN ANALYSIS OF THE PROPULSION EXPERIMENTS PER- Final FORMED ON A MODEL REPRESENTING THE STRETCHED PONCE DE LEON (SPDL...number) A ser ies of propulsion exper ments were performed on Model 5362, representing a Stretched PONCE DE LEON Clas RO/RO ship. The model was fitted

  7. Water Quality of Hills Water, Supply Water and RO Water Machine at Ulu Yam Selangor

    Science.gov (United States)

    Ngadiman, N.; ‘I Bahari, N.; Kaamin, M.; Hamid, N. B.; Mokhtar, M.; Sahat, S.

    2016-07-01

    The rapid development resulted in the deterioration of the quality of drinking water in Malaysia. Recognizing the importance of water quality, new alternatives for drinking water such as mineral water processing from reverse osmosis (RO) machine become more popular. Hence, the demand for mineral water, natural spring water or water from the hills or mountains rose lately. More consumers believed the quality of these spring water better than other source of drinking water. However, the quality of all the drinking water sources is to meet the required quality standard. Therefore, this paper aims to measure the quality of the waters from hills, from RO machine and the water supply in Ulu Yam, Selangor Batang Kali, Malaysia. The water quality was determined based on following parameters: ammoniacal nitrogen (NH3), iron (Fe), turbidity (NTU) and pH. The results show that the water from hills has better quality compared to water supply and water from RO machine. The value of NH3 ranged from 0.03 mg/L- 0.67 mg/L; Fe was from 0.03mg/L - 0.12 mg/L, turbidity at 0.42 NTU - 0.88 NTU and pH is at 6.60 - 0.71. Based on the studied parameters, all three types of water are fit for drinking and have met the required national drinking water quality standard.

  8. The CoRoT discovery of a unique triple-mode cepheid in the galaxy

    CERN Document Server

    Poretti, Ennio; Weiss, Werner W

    2014-01-01

    The exploitation of the CoRoT treasure of stars observed in the exoplanetary field allowed the detection of a unusual triple-mode Cepheid in the Milky Way, CoRoT 0223989566. The two modes with the largest amplitudes and period ratio of 0.80 are identified with the first (P1=1.29 d) and second (P2=1.03 d) radial overtones. The third period, which has the smallest amplitude but able to produce combination terms with the other two, is the longest one (P3=1.89 d). The ratio of 0.68 between the first-overtone period and the third period is the unusual feature. Its identification with the fundamental radial or a nonradial mode is discussed with respect to similar cases in the Magellanic Clouds. In both cases the period triplet and the respective ratios make the star unique in our Galaxy. The distance derived from the period-luminosity relation and the galactic coordinates put CoRoT~0223989566 in the metal-rich environment of the "outer arm" of the Milky Way.

  9. Tropical temperature variability and Kelvin-wave activity in the UTLS from GPS RO measurements

    Science.gov (United States)

    Scherllin-Pirscher, Barbara; Randel, William J.; Kim, Joowan

    2017-01-01

    Tropical temperature variability over 10-30 km and associated Kelvin-wave activity are investigated using GPS radio occultation (RO) data from January 2002 to December 2014. RO data are a powerful tool for quantifying tropical temperature oscillations with short vertical wavelengths due to their high vertical resolution and high accuracy and precision. Gridded temperatures from GPS RO show the strongest variability in the tropical tropopause region (on average 3 K2). Large-scale zonal variability is dominated by transient sub-seasonal waves (2 K2), and about half of sub-seasonal variance is explained by eastward-traveling Kelvin waves with periods of 4 to 30 days (1 K2). Quasi-stationary waves associated with the annual cycle and interannual variability contribute about a third (1 K2) to total resolved zonal variance. Sub-seasonal waves, including Kelvin waves, are highly transient in time. Above 20 km, Kelvin waves are strongly modulated by the quasi-biennial oscillation (QBO) in stratospheric zonal winds, with enhanced wave activity during the westerly shear phase of the QBO. In the tropical tropopause region, however, peaks of Kelvin-wave activity are irregularly distributed in time. Several peaks coincide with maxima of zonal variance in tropospheric deep convection, but other episodes are not evidently related. Further investigations of convective forcing and atmospheric background conditions are needed to better understand variability near the tropopause.

  10. Pregnancy outcomes in patients with autoimmune diseases and anti-Ro/SSA antibodies.

    Science.gov (United States)

    Brucato, Antonio; Cimaz, Rolando; Caporali, Roberto; Ramoni, Véronique; Buyon, Jill

    2011-02-01

    Anti-Ro/SSA antibodies are associated with neonatal lupus (congenital heart block (CHB), neonatal transient skin rash, hematological and hepatic abnormalities), but do not negatively affects other gestational outcomes, and the general outcome of these pregnancies is now good, when followed by experienced multidisciplinary teams. The prevalence of CHB, defined as an atrioventricular block diagnosed in utero, at birth, or within the neonatal period (0-27 days after birth), in the offspring of an anti-Ro/SSA-positive women is 1-2%, of neonatal lupus rash around 10-20%, while laboratory abnormalities in asymptomatic babies can be detected in up to 27% of cases. The risk of recurrence of CHB is ten times higher. Most of the mothers are asymptomatic at delivery and are identified only by the birth of an affected child. Half of these asymptomatic women develop symptoms of a rheumatic disease, most commonly arthralgias and xerophtalmia, but few develop lupus nephritis. A standard therapy for CHB is still matter of investigation, although fluorinated corticosteroids have been reported to be effective for associated cardiomyopathy. Serial echocardiograms and obstetric sonograms, performed at least every 1-2 weeks starting from the 16th week of gestational age, are recommended in anti-Ro/SSA-positive pregnant women to detect early fetal abnormalities that might be a target of preventive therapy.

  11. Galactic Archaeology with asteroseismology and spectroscopy: Red giants observed by CoRoT and APOGEE

    CERN Document Server

    Anders, F; Rodrigues, T S; Miglio, A; Montalbán, J; Mosser, B; Girardi, L; Valentini, M; Noels, A; Morel, T; Johnson, J A; Schultheis, M; Baudin, F; Peralta, R de Assis; Hekker, S; Themeßl, N; Kallinger, T; García, R A; Mathur, S; Baglin, A; Santiago, B X; Martig, M; Minchev, I; Steinmetz, M; da Costa, L N; Maia, M A G; Prieto, C Allende; Cunha, K; Beers, T C; Epstein, C; Pérez, A E García; García-Hernández, D A; Harding, P; Holtzman, J; Majewski, S R; Mészáros, Sz; Nidever, D; Pan, K; Pinsonneault, M; Schiavon, R P; Schneider, D P; Shetrone, M D; Stassun, K; Zamora, O; Zasowski, G

    2016-01-01

    With the advent of the space missions CoRoT and Kepler, it has become feasible to determine precise asteroseismic masses and ages for large samples of red-giant stars. In this paper, we present the CoRoGEE dataset -- obtained from CoRoT lightcurves for 606 red giant stars in two fields of the Galactic disc which have been co-observed for an ancillary project of APOGEE. We have used the Bayesian parameter estimation code PARAM to calculate distances, extinctions, masses, and ages for these stars in a homogeneous analysis, resulting in relative statistical uncertainties of $\\sim2\\%$ in distance, $\\sim4\\%$ in radius, $\\sim9\\%$ in mass and $\\sim25\\%$ in age. We also assess systematic age uncertainties due to different input physics and mass loss. We discuss the correlation between ages and chemical abundance patterns of field stars over a large radial range of the Milky Way's disc (5 kpc $

  12. Removal of emerging contaminants from municipal wastewater with an integrated membrane system, MBR-RO.

    Science.gov (United States)

    Dolar, Davor; Gros, Meritxell; Rodriguez-Mozaz, Sara; Moreno, Jordi; Comas, Joaquim; Rodriguez-Roda, Ignasi; Barceló, Damià

    2012-11-15

    The presence of emerging contaminants in the aquatic environment and their potential effects on living organisms has become an issue of growing concern. Among emerging contaminants, pharmaceuticals may enter the aquatic environment due to their high consumption and their incomplete removal in conventional municipal wastewater treatment plants (WWTPs). The main goal of this study was the assessment of the removal efficiency of pharmaceuticals found in municipal wastewater of a coastal WWTP (Castell-Platja d'Aro, Spain) using an integrated pilot scale membrane system (MBR-RO). Twenty multiple-class pharmaceuticals (including psychiatric drugs, macrolide antibiotics, β-blockers, sulfonamide and fluoroquinolone antibiotics, histamine H2 receptor antagonists, anti-inflammatories, nitroimidazole, β-agonist and antiplatelet agent) were measured in real influent with the lowest average concentration for psychiatric drugs (0.017 μg L(-1)) to the highest for macrolide antibiotics (2.02 μg L(-1)). Although some contaminants were in relatively high concentrations (even up to 2.90 μg L(-1) in the case of ofloxacin). The combination of MBR and RO treatment showed excellent overall removal of target emerging contaminants with removal rates above 99% for all of them. For some compounds (metronidazole, hydrocodone, codein, ranitidine) MBR provided high removal efficiency (up to 95%). Additionally RO membrane showed removal rates always higher than 99%.

  13. RoCoMAR: Robots’ Controllable Mobility Aided Routing and Relay Architecture for Mobile Sensor Networks

    Directory of Open Access Journals (Sweden)

    Seokhoon Yoon

    2013-07-01

    Full Text Available In a practical deployment, mobile sensor network (MSN suffers from a low performance due to high node mobility, time-varying wireless channel properties, and obstacles between communicating nodes. In order to tackle the problem of low network performance and provide a desired end-to-end data transfer quality, in this paper we propose a novel ad hoc routing and relaying architecture, namely RoCoMAR (Robots’ Controllable Mobility Aided Routing that uses robotic nodes’ controllable mobility. RoCoMAR repeatedly performs link reinforcement process with the objective of maximizing the network throughput, in which the link with the lowest quality on the path is identified and replaced with high quality links by placing a robotic node as a relay at an optimal position. The robotic node resigns as a relay if the objective is achieved or no more gain can be obtained with a new relay. Once placed as a relay, the robotic node performs adaptive link maintenance by adjusting its position according to the movements of regular nodes. The simulation results show that RoCoMAR outperforms existing ad hoc routing protocols for MSN in terms of network throughput and end-to-end delay.

  14. Exploring the helium core of the delta Scuti star CoRoT 102749568 with asteroseismology

    CERN Document Server

    Chen, Xinghao; Lin, Guifang; Chen, Yanhui; Guo, Junjun

    2016-01-01

    Based on regularities in rotational splittings, we seek possible multiplets for the observed frequencies of CoRoT 102749568. Twenty-one sets of multiplets are identified, including four sets of multiplets with $l=1$, nine sets of multiplets with $l=2$, and eight sets of multiplets with $l=3$. In particular, there are three complete triplets ($f_{10}$, $f_{12}$, $f_{14}$), ($f_{31}$, $f_{34}$, $f_{35}$), and ($f_{41}$, $f_{43}$, $f_{44}$). The rotational period of CoRoT 102749568 is estimated to be $1.34^{+0.04}_{-0.05}$ days. When doing model fittings, three $l=1$ modes ($f_{12}$, $f_{34}$, and $f_{43}$) and the radial first overtone $f_{13}$ are used. Our results shows that the three nonradial modes ($f_{12}$, $f_{34}$, and $f_{43}$) are mixed modes, which mainly provide constraints on the helium core. The radial first overtone $f_{13}$ mainly provides constraint on the stellar envelope. Hence the size of the helium core of CoRoT 102749568 is determined to be $M_{\\rm He}$ = 0.148 $\\pm$ 0.003 $M_{\\odot}$ and ...

  15. Surface structure of the CoRoT CP2 target star HD 50773

    CERN Document Server

    Lüftinger, T; Weiss, W; Petit, P; Aurière, M; Nesvacil, N; Gruberbauer, M; Shulyak, D; Alecian, E; Baglin, A; Baudin, F; Catala, C; Donati, J -F; Kochukhov, O; Michel, E; Piskunov, N; Roudier, T; Samadi, R

    2009-01-01

    We compare surface maps of the chemically peculiar star HD 50773 produced with a Bayesian technique and based on high quality CoRoT photometry with those derived from rotation phase resolved spectropolarimetry. The goal is to investigate the correlation of surface brightness with surface chemical abundance distribution and the stellar magnetic field. The rotational period of the star was determined from a nearly 60 day long continuous light curve obtained during the initial run of CoRoT. Using a Bayesian approach to star-spot modelling, which in this work is applied for the first time for the photometric mapping of a CP star, we derived longitudes, latitudes and radii of four different spot areas. Additional parameters like stellar inclination and the spot's intensities were also determined. The CoRoT observations triggered an extensive ground-based spectroscopic and spectropolarimetric observing campaign and enabled us to obtain 19 different high resolution spectra in Stokes parameters I and V with NARVAL, E...

  16. The variability behavior of CoRoT M-giant Stars

    CERN Document Server

    Lopes, C E Ferreira; Leão, I C; de Freitas, D B; Martins, B L Canto; da Costa, A D; Paz-Chinchón, F; Chagas, M L Das; Baglin, A; Janot-Pacheco, E; De Medeiros, J R

    2015-01-01

    For 6 years the Convection, Rotation, and Planetary Transits (CoRoT) space mission has acquired photometric data from more than one hundred thousand point sources towards and directly opposite from the inner and outer regions of the Galaxy. The high temporal resolution of the CoRoT data combined with the wide time span of the observations has enabled the study of short and long time variations in unprecedented detail. From the initial sample of 2534 stars classified as M-giants in the CoRoT databasis, we selected 1428 targets that exhibit well defined variability, using visual inspection. The variability period and amplitude of C1 stars (stars having Teff < 4200 K) were computed using Lomb-Scargle and harmonic fit methods. The trends found in the V-I vs J-K color-color diagram are in agreement with standard empirical calibrations for M-giants. The sources located towards the inner regions of the Galaxy are distributed throughout the diagram while the majority of the stars towards the outer regions of the G...

  17. A MCDM Analysis of the Roşia Montană Gold Mining Project

    Directory of Open Access Journals (Sweden)

    Adriana Mihai

    2015-06-01

    Full Text Available The need and estimated utility for a structured analysis of the Roşia Montană gold exploitation project have been palpable in the Romanian public sphere during the last 15 years and there is a vast amount of conflicting information and opinions on the benefits and risks involved. This article provides a comprehensive decision analysis of the Roşia Montană project. Over 100 documents from the past years have been gathered regarding the Roşia Montană mining project, which cover the main official, formal and less formal documents covering the case and produced by a wide range of stakeholders. These were then analyzed while designing a multi-criteria tree including the relevant perspectives under which the most commonly discussed four alternatives were analyzed. The result of this can be translated into a valuable recommendation for the mining company and for the political decision-makers. If these stakeholders want the continuation of the project and its acceptance by civil society, the key challenge is to increase the transparency of the process and improve the credibility and legal aspects; if these aspects cannot be met, the decision-makers need to pay attention to the alternatives available for a sustainable development in the area.

  18. Noise properties of the CoRoT data: a planet-finding perspective

    CERN Document Server

    Aigrain, S; Fressin, F; Alapini, A; Alonso, R; Auvergne, M; Barbieri, M; Barge, P; Borde, P; Bouchy, F; Deeg, H; De la Reza, R; Deleuil, M; Dvorak, R; Erikson, A; Fridlund, M; Gondoin, P; Guterman, P; Jorda, L; Lammer, H; Léger, A; llebaria, A; Magain, P; Mazeh, T; Moutou, C; Ollivier, M; Paezold, M; Queloz, D; Rauer, H; Rouan, D; Schneider, J; Wuchterl, G; Zucker, S

    2009-01-01

    In this short paper, we study the photometric precision of stellar light curves obtained by the CoRoT satellite in its planet finding channel, with a particular emphasis on the timescales characteristic of planetary transits. Together with other articles in the same issue of this journal, it forms an attempt to provide the building blocks for a statistical interpretation of the CoRoT planet and eclipsing binary catch to date. After pre-processing the light curves so as to minimise long-term variations and outliers, we measure the scatter of the light curves in the first three CoRoT runs lasting more than 1 month, using an iterative non-linear filter to isolate signal on the timescales of interest. The bevhaiour of the noise on 2h timescales is well-described a power-law with index 0.25 in R-magnitude, ranging from 0.1mmag at R=11.5 to 1mmag at R=16, which is close to the pre-launch specification, though still a factor 2-3 above the photon noise due to residual jitter noise and hot pixel events. There is evide...

  19. An Intercomparison of GPS RO Retrievals with Colocated Analysis and In Situ Observations within Tropical Cyclones

    Directory of Open Access Journals (Sweden)

    Henry R. Winterbottom

    2010-01-01

    Full Text Available Observations from four Global Position System (GPS Radio Occultation (RO missions: Global Positioning System/Meteorology, CHAallenging Minisatellite Payload, Satellite de Aplicaciones Cientificas-C, and Constellation Observing System for Meteorology, Ionosphere and Climate and Taiwan's FORMOsa SATellite Mission #3 (COSMIC/FORMOSAT-3 are collected within a 600 km radius and ±180 minute temporal window of all observed tropical cyclones (TCs from 1995 to 2006 that were recorded in the global hurricane best-track reanalysis data set (Jarvinen et al. (1984; Davis et al. (1984. A composite analysis of tropical cyclone radial mean temperature and water vapor profiles is carried out using the GPS RO retrievals which are colocated with global analysis profiles and available in situ radiosonde observations. The differences between the respective observations and analysis profiles are quantified and the preliminary results show that the observations collected within TCs correspond favorably with both the analysis and radiosonde profiles which are colocated. It is concluded that GPS RO observations will contribute significantly to the understanding and modeling of TC structures, especially those related to vertical variability of the atmospheric state within TCs.

  20. 台湾海峡客滚直航与水文气象研究%On Ro- Ro Passenger Ship Direct Cross- Taiwan Strait and Hydrological - Meteorology Conditions

    Institute of Scientific and Technical Information of China (English)

    翁国玲; 唐寒秋; 陈宏; 李道科

    2011-01-01

    Based on analysis of many traffic investigation, comprehensive analysis between Fujian and Taiwan direct route opening ro - ro passenger of various factors, using the maritime traffic engineering theory, the method and risk prevention principle of Fujian and Taiwan direct cross - strait ro - ro passenger ship security for the related problems on research, put forward the corresponding security measures and management suggestions from Ship type selection, route choice etc.. In order to open Fujian and Taiwan direct cross -strait ro -ro passenger transportation, the paper puts forwards some advices.%基于大量的资料,交通调查研究与分析的基础上,综合分析闽台开通客滚直航航线的气象水文等因素,运用海上交通工程的理论、方法对闽台两岸客滚船直航安全保障的相关问题进行研究,从船型选择、航线选择等方面提出相应的安全保障措施与管理建议,以期对开辟闽台两岸客滚直航运输的运输安全提供建议。

  1. Research on Business Process Simulation and Process Reengineering in Automobile Ro-Ro Terminals%汽车滚装码头业务流程仿真及流程再造研究

    Institute of Scientific and Technical Information of China (English)

    曹玉莲; 李文锋

    2011-01-01

    汽车滚装是汽车物流的重要形式.我国汽车滚装发展迅猛,但其业务流程较为传统,服务水平难以适应现代物流需求.在调研汽车滚装码头的基础上,对业务流程进行分析.通过仿真建模方法找出流程的瓶颈,提出改进措施,进行业务流程优化,并对再造后的流程进行分析,证明了流程改进的合理性.%Automobile Ro-Ro is an important form of automobile logistics. Our automobile Ro-Ro is developing rapidly, but its business process is more traditional. Service level is difficult to adapt to the modern logistics needs. This paper analysis the business processes based on the investigation of automobile Ro-Ro yard. Through the simulation modeling methods, the bottlenecks are exposed. Then it proposes the improvement measures and implements business process optimization. Finally, this paper analyzes the modified process by simulation to prove the rationality of the process improvement.

  2. Implementation of a GPS-RO data processing system for the KIAPS-LETKF data assimilation system

    National Research Council Canada - National Science Library

    H Kwon; J-S Kang; Y Jo; J H Kang

    2015-01-01

    .... As part of the KIAPS package for observation processing (KPOP) system for data assimilation, preprocessing, and quality control modules for bending-angle measurements of global positioning system radio occultation (GPS-RO...

  3. Implementation of a GPS-RO data processing system for the KIAPS-LETKF data assimilation system

    National Research Council Canada - National Science Library

    H. Kwon; J.-S. Kang; Y. Jo; J. H. Kang

    2014-01-01

    .... As part of the KIAPS Package for Observation Processing (KPOP) system for data assimilation, preprocessing and quality control modules for bending angle measurements of global positioning system radio occultation (GPS-RO...

  4. ÜRO mereõiguse konventsioonide tõlgendamisel ja kohaldamisel tekkivate riikidevaheliste vaidluste lahendamise kord / Kristi Land

    Index Scriptorium Estoniae

    Land, Kristi, 1973-

    2006-01-01

    Lisatud tabelid: Kokkuvõte (vahe)kohtute pädevusest ÜRO 1982. aasta mereõiguse konventsiooni alusel ; Menetluse valik mereõiguse konventsiooni artikli 287(1) kohaselt ; Reservatsioonid artikli 298(1) alusel

  5. Characterization of CoRoT target fields with BEST: Identification of periodic variable stars in the IR01 field

    CERN Document Server

    Kabath, P; Erikson, A; Hedelt, P; Rauer, H; Titz, R; Wiese, T; 10.1086/521554

    2009-01-01

    We report on observations of the CoRoT IR01 field with the Berlin Exoplanet Search Telescope (BEST). BEST is a small aperture telescope with a wide field of view (FOV). It is dedicated to search for variable stars within the target fields of the CoRoT space mission to aid in minimizing false-alarm rates and identify potential targets for additional science. CoRoT's observational programm started in February 2007 with the "initial run" field (IR01) observed for about two months. BEST observed this field for 12 nights spread over three months in winter 2006. From the total of 30426 stars observed in the IR01 field 3769 were marked as suspected variable stars and 54 from them showed clear periodicity. From these 19 periodic stars are within the part of the CoRoT FOV covered in our data set.

  6. Chemoradioprotection of the rat parotid gland by combined use of WR-2721 and Ro-07-0582

    Energy Technology Data Exchange (ETDEWEB)

    Sodicoff, M.; Conger, A.D.; Pratt, N.E.; Sinesi, M.; Trepper, P.

    1979-11-01

    The radioprotection of the rat parotid gland by WR-2721 alone (DMF, 2.4) was compared to the protection afforded when WR-2721 was given in combination with the hypoxic cell radiosensitizer Ro-07-0582 (DMF, 2.6). It was concluded that the radiosensitizer of malignant tumor cells Ro-07-0582 was compatible with and did not reduce the protection of normal tissue afforded by WR-2721.

  7. Enzymatic cleaning of biofouled thin-film composite reverse osmosis (RO) membrane operated in a biofilm membrane reactor.

    Science.gov (United States)

    Khan, Mohiuddin; Danielsen, Steffen; Johansen, Katja; Lorenz, Lindsey; Nelson, Sara; Camper, Anne

    2014-02-01

    Application of environmentally friendly enzymes to remove thin-film composite (TFC) reverse osmosis (RO) membrane biofoulants without changing the physico-chemical properties of the RO surface is a challenging and new concept. Eight enzymes from Novozyme A/S were tested using a commercially available biofouling-resistant TFC polyamide RO membrane (BW30, FilmTech Corporation, Dow Chemical Co.) without filtration in a rotating disk reactor system operated for 58 days. At the end of the operation, the accumulated biofoulants on the TFC RO surfaces were treated with the three best enzymes, Subtilisin protease and lipase; dextranase; and polygalacturonase (PG) based enzymes, at neutral pH (~7) and doses of 50, 100, and 150 ppm. Contact times were 18 and 36 h. Live/dead staining, epifluorescence microscopy measurements, and 5 μm thick cryo-sections of enzyme and physically treated biofouled membranes revealed that Subtilisin protease- and lipase-based enzymes at 100 ppm and 18 h contact time were optimal for removing most of the cells and proteins from the RO surface. Culturable cells inside the biofilm declined by more than five logs even at the lower dose (50 ppm) and shorter incubation period (18 h). Subtilisin protease- and lipase-based enzyme cleaning at 100 ppm and for 18 h contact time restored the hydrophobicity of the TFC RO surface to its virgin condition while physical cleaning alone resulted in a 50° increase in hydrophobicity. Moreover, at this optimum working condition, the Subtilisin protease- and lipase-based enzyme treatment of biofouled RO surface also restored the surface roughness measured with atomic force microscopy and the mass percentage of the chemical compositions on the TFC surface estimated with X-ray photoelectron spectroscopy to its virgin condition. This novel study will encourage the further development and application of enzymes to remove biofoulants on the RO surface without changing its surface properties.

  8. Monoamine oxidase B single-photon emission tomography with [{sup 123}I]Ro 43-0463: imaging in volunteers and patients with temporal lobe epilepsy

    Energy Technology Data Exchange (ETDEWEB)

    Buck, A. [Division of Nuclear Medicine, University Hospital Zurich (Switzerland); Frey, L.D. [Department of Nuclear Medicine, Kantonsspital Aarau (Switzerland); Blaeuenstein, P.; Schubiger, P. [Paul Scherrer Institut, Radiopharmacy Division, Villigen (Switzerland); Kraemer, G. [Swiss Epilepsy Clinic, Zurich (Switzerland); Siegel, A.; Weber, B.; Wieser, H.G. [Department of Neurology, University Hospital Zurich (Switzerland)

    1998-05-01

    Imaging of monoamine oxidase of subtype B (MAO B) is of interest in various neurological diseases. In the past non-invasive assessment of MAO B has only been possible with positron emission tomography (PET) ligands. Given the limited availability of PET, a single-photon emission tomography (SPET) ligand would be desirable. In this study SPET imaging with the new MAO B inhibitor [{sup 123}I]Ro 43-0463 was performed in five volunteers and nine patients with temporal lobe epilepsy (TLE). In two volunteers a second study was performed 12 h following blockade with deprenyl. In the TLE patients the tracer was administered as bolus (n = 4) or as prolonged infusion (n = 5). The regional uptake pattern correlated well with the known distribution of MAO B. In the two blocking studies ligand uptake was substantially reduced compared with baseline. In the TLE patients increased uptake was found in the ipsilateral mesial temporal lobe and, surprisingly, in the ipsilateral putamen. This study indicates the potential of the new SPET ligand [{sup 123}I]Ro 43-0463 to map MAO B concentration in the human brain. The new finding of increased MAO B in the putamen of TLE patients needs further studies to elucidate its exact pathophysiology. (orig.) With 3 figs., 3 tabs., 28 refs.

  9. Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBFβ interaction.

    Science.gov (United States)

    Cunningham, Lea; Finckbeiner, Steven; Hyde, R Katherine; Southall, Noel; Marugan, Juan; Yedavalli, Venkat R K; Dehdashti, Seameen Jean; Reinhold, William C; Alemu, Lemlem; Zhao, Ling; Yeh, Jing-Ruey Joanna; Sood, Raman; Pommier, Yves; Austin, Christopher P; Jeang, Kuan-Teh; Zheng, Wei; Liu, Paul

    2012-09-04

    Core binding factor (CBF) leukemias, those with translocations or inversions that affect transcription factor genes RUNX1 or CBFB, account for ~24% of adult acute myeloid leukemia (AML) and 25% of pediatric acute lymphocytic leukemia (ALL). Current treatments for CBF leukemias are associated with significant morbidity and mortality, with a 5-y survival rate of ~50%. We hypothesize that the interaction between RUNX1 and CBFβ is critical for CBF leukemia and can be targeted for drug development. We developed high-throughput AlphaScreen and time-resolved fluorescence resonance energy transfer (TR-FRET) methods to quantify the RUNX1-CBFβ interaction and screen a library collection of 243,398 compounds. Ro5-3335, a benzodiazepine identified from the screen, was able to interact with RUNX1 and CBFβ directly, repress RUNX1/CBFB-dependent transactivation in reporter assays, and repress runx1-dependent hematopoiesis in zebrafish embryos. Ro5-3335 preferentially killed human CBF leukemia cell lines, rescued preleukemic phenotype in a RUNX1-ETO transgenic zebrafish, and reduced leukemia burden in a mouse CBFB-MYH11 leukemia model. Our data thus confirmed that RUNX1-CBFβ interaction can be targeted for leukemia treatment and we have identified a promising lead compound for this purpose.

  10. Galactic archaeology with asteroseismology and spectroscopy: Red giants observed by CoRoT and APOGEE

    Science.gov (United States)

    Anders, F.; Chiappini, C.; Rodrigues, T. S.; Miglio, A.; Montalbán, J.; Mosser, B.; Girardi, L.; Valentini, M.; Noels, A.; Morel, T.; Johnson, J. A.; Schultheis, M.; Baudin, F.; de Assis Peralta, R.; Hekker, S.; Themeßl, N.; Kallinger, T.; García, R. A.; Mathur, S.; Baglin, A.; Santiago, B. X.; Martig, M.; Minchev, I.; Steinmetz, M.; da Costa, L. N.; Maia, M. A. G.; Allende Prieto, C.; Cunha, K.; Beers, T. C.; Epstein, C.; García Pérez, A. E.; García-Hernández, D. A.; Harding, P.; Holtzman, J.; Majewski, S. R.; Mészáros, Sz.; Nidever, D.; Pan, K.; Pinsonneault, M.; Schiavon, R. P.; Schneider, D. P.; Shetrone, M. D.; Stassun, K.; Zamora, O.; Zasowski, G.

    2017-01-01

    With the advent of the space missions CoRoT and Kepler, it has recently become feasible to determine precise asteroseismic masses and relative ages for large samples of red giant stars. We present the CoRoGEE dataset, obtained from CoRoT light curves for 606 red giants in two fields of the Galactic disc that have been co-observed by the Apache Point Observatory Galactic Evolution Experiment (APOGEE). We used the Bayesian parameter estimation code PARAM to calculate distances, extinctions, masses, and ages for these stars in a homogeneous analysis, resulting in relative statistical uncertainties of ≲2% in distance, 4% in radius, 9% in mass and 25% in age. We also assessed systematic age uncertainties stemming from different input physics and mass loss. We discuss the correlation between ages and chemical abundance patterns of field stars over a broad radial range of the Milky Way disc (5 kpc RoGEE observations of a chemodynamical Milky Way disc model indicate that the number of high-metallicity stars in the outer disc is too high to be accounted for even by the strong radial mixing present in the model. The mock observations also show that the age distribution of the [α/Fe]-enhanced sequence in the CoRoGEE inner-disc field is much broader than expected from a combination of radial mixing and observational errors. We suggest that a thick-disc/bulge component that formed stars for more than 3 Gyr may account for these discrepancies. Our results are subject to future improvements due to (a) the still low statistics, because our sample had to be

  11. Determination of the in vivo redox potential using roGFP and fluorescence spectra obtained from one-wavelength excitation

    Science.gov (United States)

    Wierer, S.; Elgass, K.; Bieker, S.; Zentgraf, U.; Meixner, A. J.; Schleifenbaum, F.

    2011-02-01

    The analysis of molecular processes in living (plant) cells such as signal transduction, DNA replication, carbon metabolism and senescence has been revolutionized by the use of green fluorescent protein (GFP) and its variants as specific cellular markers. Many cell biological processes are accompanied by changes in the intracellular redox potential. To monitor the redox potential, a redox-sensitive mutant of GFP (roGFP) was created, which shows changes in its optical properties in response to changes in the redox state of its surrounding medium. For a quantitative analysis in living systems, it is essential to know the optical properties of roGFP in vitro. Therefore, we applied spectrally resolved fluorescence spectroscopy on purified roGFP exposed to different redox potentials to determine shifts in both the absorption and the emission spectra of roGFP. Based on these in vitro findings, we introduce a new approach using one-wavelength excitation to use roGFP for the in vivo analysis of cell biological processes. We demonstrate the ability this technique by investigating chloroplast-located Grx1-roGFP2 expressing Arabidopsis thaliana cells as example for dynamically moving intracellular compartments. This is not possible with the two-wavelength excitation technique established so far, which hampers a quantitative analysis of highly mobile samples due to the time delay between the two measurements and the consequential displacement of the investigated area.

  12. Evaluation of the ethanol antagonist' Ro15-4513 on cardiovascular and metabolic responses induced by ethanol

    Energy Technology Data Exchange (ETDEWEB)

    Lerner, M.R.; Gauvin, D.V.; Holloway, F.A.; Wilson, M.F.; Brackett, D.J. (Univ. of Oklahoma, Oklahoma City (United States) Veterans Affairs Medical Center, Oklahoma City, OK (United States))

    1992-02-26

    The putative ethanol antagonist Ro15-4513 has been reported to attenuate many behavioral responses induced by ethanol, including motor coordination, narcosis, ethanol self administration and intake, and anticonvulsant actions. This study was designed to study the effect of Ro15-4513 on cardiovascular and metabolic responses elicited by intragastric ethanol in conscious rats. Four groups of rats were catheterized under enflurane anesthesia and allowed to regain consciousness. Each group was given either 3.2, 10.0, or 32.0 mg/kg Ro15-4513 or equivalent Tween (i.p.) following ethanol. Ro15-4513 had no effect at any concentration on the decreases in mean arterial pressure, cardiac output, central venous pressure, respiration rate, and cardiac stroke volume and the increases in systemic vascular resistance, heart rate, and glucose evoked by the ethanol challenge. Blood alcohol concentrations measured throughout the study were not affected by any concentration of Ro15-4513. These data suggest that even though Ro15-4513 has significant effects on behavioral responses induced by ethanol it has no effect on the cardiovascular and metabolic responses elicited during ethanol intoxication.

  13. The Roles of Tidal Evolution and Evaporative Mass Loss in the Origin of CoRoT-7 b

    CERN Document Server

    Jackson, Brian; Barnes, Rory; Raymond, Sean N; Fortney, Jonathan; Greenberg, Richard

    2010-01-01

    CoRoT-7 b is the first confirmed rocky exoplanet, but, with an orbital semi-major axis of 0.0172 AU, its origins may be unlike any rocky planet in our solar system. In this study, we consider the roles of tidal evolution and evaporative mass loss in CoRoT-7 b's history, which together have modified the planet's mass and orbit. If CoRoT-7 b has always been a rocky body, evaporation may have driven off almost half its original mass, but the mass loss may depend sensitively on the extent of tidal decay of its orbit. As tides caused CoRoT-7 b's orbit to decay, they brought the planet closer to its host star, thereby enhancing the mass loss rate. Such a large mass loss also suggests the possibility that CoRoT-7 b began as a gas giant planet and had its original atmosphere completely evaporated. In this case, we find that CoRoT-7 b's original mass probably didn't exceed 200 Earth masses (about 2/3 of a Jupiter mass). Tides raised on the host star by the planet may have significantly reduced the orbital semi-major a...

  14. Association of increased frequencies of HLA-DPB1*05:01 with the presence of anti-Ro/SS-A and anti-La/SS-B antibodies in Japanese rheumatoid arthritis and systemic lupus erythematosus patients.

    Directory of Open Access Journals (Sweden)

    Hiroshi Furukawa

    Full Text Available INTRODUCTION: Autoantibodies to ribonucleoprotein are associated with a variety of autoimmune diseases, including rheumatoid arthritis (RA. Many studies on associations between human leukocyte antigen (HLA alleles and RA have been reported, but few have been validated in RA subpopulations with anti-La/SS-B or anti-Ro/SS-A antibodies. Here, we investigated associations of HLA class II alleles with the presence of anti-Ro/SS-A or anti-La/SS-B antibodies in RA. METHODS: An association study was conducted for HLA-DRB1, DQB1, and DPB1 in Japanese RA and systemic lupus erythematosus (SLE patients that were positive or negative for anti-Ro/SS-A and/or anti-La/SS-B antibodies. RESULTS: An increased prevalence of certain class II alleles was associated with the presence of anti-Ro/SS-A antibodies as follows: DRB1*08:03 (Pc = 3.79×10(-5, odds ratio [OR] 3.06, 95% confidence interval [CI] 1.98-4.73, DQB1*06:01 (Pc = 0.0106, OR 1.70, 95%CI 1.26-2.31, and DPB1*05:01 (Pc = 0.0040, OR 1.55, 95%CI 1.23-1.96. On the other hand, DRB1*15:01 (Pc = 0.0470, OR 3.14, 95%CI 1.63-6.05, DQB1*06:02 (Pc = 0.0252, OR 3.14, 95%CI 1.63-6.05, and DPB1*05:01 (Pc = 0.0069, OR 2.27, 95% CI 1.44-3.57 were associated with anti-La/SS-B antibodies. The DPB1*05:01 allele was associated with anti-Ro/SS-A (Pc = 0.0408, OR 1.69, 95% CI 1.19-2.41 and anti-La/SS-B antibodies (Pc = 2.48×10(-5, OR 3.31, 95%CI 2.02-5.43 in SLE patients. CONCLUSION: HLA-DPB1*05:01 was the only allele associated with the presence of both anti-Ro/SS-A and anti-La/SS-B antibodies in Japanese RA and SLE patients.

  15. Water pollution in gold mining industry: a case study in Roşia Montană district, Romania

    Science.gov (United States)

    Florea, R. M.; Stoica, A. I.; Baiulescu, G. E.; Capotă, P.

    2005-10-01

    The preliminary study of streams and rivers from the Roşia Montană area revealed that the concntration of heavy metals— Cd, Mn, Cu, Pb, and Zn—are above accepted limits. The gold extraction method is based on flotation. The most important pollution sources are mine tailings. The determinations were performed for samples collected in: April 2004, July 2004, September 2004, November 2004, February 2005 and May 2005. The highest concentrations were found for cadmium in September 2004: 0.17 mg/L; for copper in September 2004: 1.38 mg/L; for manganese in July 2004: 239.4 mg/L; for lead in May 2005: 0.54 mg/L; and for zinc in September 2004: 35.37 mg/L;. This study involved three small rivers (streams) that flow into the Mureş River and finally into the Danube River, having a great impact on human health and environmental stability in the area. In May 2005, a sample of drinking water from the mining district was also collected.

  16. RoHS verification using XRF%使用荧光光谱分析法(XRF)进行RoHS验证

    Institute of Scientific and Technical Information of China (English)

    杨建生

    2006-01-01

    随着欧盟RoHS最后期限的临近,很多公司都开始采用无铅化工艺,但要确保工艺的一致性,有效的检测方法是必不可缺的,荧光光谱分析法(XRF)就是其中之一。许多晶圆制造厂已开始用XRF法在薄镀层上进行光危害性成分测量,而且还用它探测扩散阻挡层裂口。

  17. Vasodilatory effect of the stable vasoactive intestinal peptide analog RO 25-1553 in murine and rat lungs.

    Directory of Open Access Journals (Sweden)

    Jun Yin

    Full Text Available RATIONALE: Stable analogs of vasoactive intestinal peptide (VIP have been proposed as novel line of therapy in chronic obstructive pulmonary disease (COPD based on their bronchodilatory and anti-inflammatory effects. We speculated that VIP analogs may provide additional benefits in that they exert vasodilatory properties in the lung, and tested this hypothesis in both ex vivo and in vivo models. METHODS: In isolated perfused mouse lungs and in an in vivo rat model, pulmonary blood vessels were preconstricted by hypoxia and hemodynamic changes in response to systemic (ex vivo or inhaled (in vivo administration of the cyclic VIP analog RO 25-1553 were determined. RESULTS: In mouse lungs, RO 25-1553 reduced intrinsic vascular resistance at normoxia, and attenuated the increase in pulmonary artery pressure in response to acute hypoxia. Consistently, inhalation of RO 25-1553 (1 mg · mL(-1 for 3 min caused an extensive and sustained (> 60 min inhibition of the pulmonary arterial pressure increase in response to hypoxia in vivo that was comparable to the effects of inhaled sildenafil. This effect was not attributable to systemic cardiovascular effects of RO 25-1553, but to a lung specific reduction in pulmonary vascular resistance, while cardiac output and systemic arterial hemodynamics remained unaffected. No adverse effects of RO 25-1553 inhalation on pulmonary gas exchange, ventilation-perfusion matching, or lung fluid content were detected. CONCLUSION: Our findings demonstrate that inhaled delivery of the stable VIP analog RO 25-1553 induces a potent and sustained vasodilatory effect in the pulmonary circulation with no detectable adverse effects. Therapeutic inhalation of RO 25-1553 may provide vascular benefits in addition to its reported anti-inflammatory and bronchodilatory effects in COPD, yet caution is warranted given the overall poor results of vasodilator therapies for pulmonary hypertension secondary to COPD in a series of recent

  18. Characterization and biotoxicity assessment of dissolved organic matter in RO concentrate from a municipal wastewater reclamation reverse osmosis system.

    Science.gov (United States)

    Sun, Ying-Xue; Gao, Yue; Hu, Hong-Ying; Tang, Fang; Yang, Zhe

    2014-12-01

    Reverse osmosis (RO) concentrate from municipal wastewater reclamation reverse osmosis (mWRRO) system containing organic compounds may associate with toxic risk, and its discharge might pose an environmental risk. To identify a basis for the selection of feasible technology in treating RO concentrates, the characteristics and biotoxicity of different fractions of dissolved organic matter (DOM) in RO concentrates from an mWRRO system were investigated. The results indicated that the hydrophilic neutrals (HIN), hydrophobic acids (HOA) and hydrophobic bases (HOB) accounted for 96% of the dissolved organic carbon (DOC) of the total DOM in the RO concentrate. According to the SEC chromatograph detected at 254 nm wavelength of UV, the DOM with molecular weight (MW) 1-3 kDa accounted for the majority of the basic and neutral fractions. The fluorescence spectra of the excitation emission matrix (EEM) indicated that most aromatic proteins, humic/fulvic acid-like and soluble microbial by-product-like substances existed in the fractions HOA and hydrophobic neutrals (HON). The genotoxicity and anti-estrogenic activity of the RO concentrate were 1795.6 ± 57.2 μg 4-NQOL(-1) and 2.19 ± 0.05 mg TAM L(-1), respectively. The HIN, HOA, and HOB contributed to the genotoxicity of the RO concentrate, and the HIN was with the highest genotoxic level of 1007.9 ± 94.8 μg 4-NQOL(-1). The HOA, HON, and HIN lead to the total anti-estrogenic activity of the RO concentrate, and HOA occupied approximately 60% of the total, which was 1.3 ± 0.17 mg TAM L(-1).

  19. Inhibition of the NOTCH pathway using γ-secretase inhibitor RO4929097 has limited antitumor activity in established glial tumors.

    Science.gov (United States)

    Dantas-Barbosa, Carmela; Bergthold, Guillaume; Daudigeos-Dubus, Estelle; Blockus, Heike; Boylan, John F; Ferreira, Celine; Puget, Stephanie; Abely, Michel; Vassal, Gilles; Grill, Jacques; Geoerger, Birgit

    2015-03-01

    Notch signaling is altered in many cancers. Our previous findings in primary pediatric ependymoma support a role for NOTCH in glial oncogenesis. The present study evaluates the γ-secretase inhibitor RO4929097 in glial tumor models. The expression of Notch pathway genes was evaluated using real-time RT-PCR in 21 ependymoma and glioma models. NOTCH1 mutations were analyzed by DNA sequencing. RO4929097 activity was evaluated in vitro and in vivo, as a single agent and in combination, in glioma and ependymoma models. Notch pathway genes are overexpressed in ependymomas and gliomas along with FBXW7 downregulation. NOTCH1 mutations in the TAD domain were observed in 20% (2/10) of ependymoma primary cultures. Blocking the Notch pathway with the γ-secretase inhibitor RO4929097 reduced cell density and viability in ependymoma short-term cultures. When combined with chemotherapeutic agents, RO4929097 enhanced temozolomide effects in ependymoma short-term cultures and potentiated the cytotoxicity of etoposide, cisplatinum, and temozolomide in glioma cells. RO4929097, in combined treatment with mTOR inhibition, potentiated cytotoxicity in vitro, but did not enhance antitumor effects in vivo. In contrast, RO4929097 enhanced irradiation effects in glioma and ependymoma xenografts and showed tumor growth inhibition in advanced-stage IGRG121 glioblastoma xenografts. RO4929097-mediated effects were independent of NOTCH1 mutation status or expression levels, but associated with low IL-6 levels. In established glial tumor models, NOTCH inhibition had limited effects as a single agent, but enhanced efficacy when combined with DNA-interfering agents. These preclinical data need to be considered for further clinical development of NOTCH inhibitors in glial tumors.

  20. Spontaneous rupture of atrioventricular valve tensor apparatus as late manifestation of anti-Ro/SSA antibody-mediated cardiac disease.

    Science.gov (United States)

    Cuneo, Bettina F; Fruitman, Deborah; Benson, D Woodrow; Ngan, Bo-Yee; Liske, Michael R; Wahren-Herlineus, Marie; Ho, S Yen; Jaeggi, Edgar

    2011-03-01

    Atrioventricular (AV) block and endocardial fibroelastosis associated with dilated cardiomyopathy are the most common clinical manifestations of anti-Ro/SSA-mediated fetal cardiac disease. Valvar dysfunction has not been a prominent feature of this disease; however, recent anecdotal cases have suggested an association between rupture of the AV valve tensor apparatus and maternal anti-Ro/SSA antibodies. In the present study, we have described the clinical and laboratory findings and reviewed the published data for infants of anti-Ro/SSA-positive pregnancies with AV valve insufficiency due to chordal rupture from the papillary muscles. The histopathologic features of the papillary muscle and ventricular free wall and septum biopsy specimens were examined and compared to the sections of AV leaflets from 6 autopsied fetuses with anti-Ro/SSA-mediated complete AV block without chordal disruption. Specific epitopes to the p200 region of Ro52, and Ro60 antibodies were evaluated in cases with chordal rupture. Severe AV valve insufficiency was detected prenatally (as early as 34 weeks of gestation) or postnatally (as late as 182 days) after areas of patchy echogenicity were noted in the papillary muscle at 19 to 22 weeks of gestation. Postnatally, urgent valve surgery was performed in 5 of 6 patients; 1 of 6 patients died preoperatively. All patients tested positive for Ro52. Valve leaflet tissue from the autopsy specimens was normal. The ventricular free wall and septum biopsy specimens from a patient with chordal rupture showed normal tissue; however, the papillary muscle biopsy specimens demonstrated severe atrophy with near total replacement of myocytes by fibrosis and dystrophic calcifications, and negative immunochemistry findings. In conclusion, these findings have defined an underappreciated complication of fetal antibody-mediated cardiac inflammation.

  1. Effects of the novel 5-HT(6) receptor antagonist RO4368554 in rat models for cognition and sensorimotor gating.

    Science.gov (United States)

    Schreiber, Rudy; Vivian, Jef; Hedley, Linda; Szczepanski, Krystine; Secchi, Rob L; Zuzow, Marcus; van Laarhoven, Susanne; Moreau, Jean-Luc; Martin, James R; Sik, Ayhan; Blokland, Arjan

    2007-03-01

    Serotonin(6) (5-HT(6)) receptors are almost exclusively located in the central nervous system. High expression in the hippocampus, nucleus accumbens and striatum is consistent with a potential role in cognition and psychosis. The availability of potent, selective and brain-penetrating 5-HT(6) antagonists such as RO4368554 allows further characterization of the role of the 5-HT(6) receptor in these processes. Herein, we tested RO4368554 in several cognition tasks, as well as sensorimotor gating tests. Using scopolamine-impaired and unimpaired adult male rats, RO4368554 was given in novel object discrimination, social recognition, social discrimination, Morris water maze, passive avoidance and autoshaping procedures. RO4368554 reversed the effects of scopolamine in novel object discrimination (active doses in mg/kg, i.p., 3, 10), social recognition (3, 10), social discrimination (1, 3, 10) and passive avoidance (10, 30 i.p. and 100 p.o.) tasks. In unimpaired rats, RO4368554 enhanced object discrimination (3, 10; 4-h forgetting interval) and autoshaping learning (3), but was inactive in a water maze task (doses tested: 1-10 mg/kg, i.p.). In tests sensitive to antipsychotics, RO4368554 did not reverse sensorimotor gating deficits induced by the psychostimulants dizocilpine and amphetamine (doses tested: 1-30 mg/kg, i.p.) or neonatal lesion of the ventral hippocampus (1-10 mg/kg, i.p.). In conclusion, RO4368554 enhanced learning and memory processes in unimpaired and scopolamine-impaired rats, supporting the notion that the cognitive enhancing effects of 5-HT(6) receptor antagonists involve modulation of cholinergic neurotransmission.

  2. Five Years of the RoBOT "Rocks Beneath Our Toes" High School Outreach Program

    Science.gov (United States)

    Baxter, E. F.

    2011-12-01

    The "Rocks Beneath Our Toes" or RoBOT Program began in 2006 as part of an NSF CAREER award through the Geochemistry and Petrology Program. The educational outreach program engages Boston area high school students in a hands on study of rocks and minerals collected in their communities. The goal is to provide high school students a unique window into modern scientific methods of geochemistry and mineralogy and create a higher level of interest and awareness of geoscience amongst Massachusetts secondary school students who are less often exposed to earth science coursework. Beginning with a joint field trip to sampling sites identified by participants, high school students work with Boston University undergraduates enrolled in Mineralogy to analyze their samples in thin section. During the field trip, each BU undergraduate is paired with a high school student. The assignment of student pairings (started in year 2) dramatically increased student interactions and enjoyment. The program culminates with a visit by the high school group to tour BU's lab facilities and work with the undergraduates using the petrographic microscopes to explore their rock. At this visit, BU undergraduates present their semester's work in one-on-one powerpoint presentations from which discussion and microscope work follow. Thus far, >50 high school students, >40 undergraduates, and 7 high school educators were involved in the program. This included participants from three different suburban Boston area high schools and with students enrolled in the BU "Upward Bound" program: an existing program designed to enhance educational opportunities for Boston inner city high school students. Participant reviews indicate great success in achieving the program's goals. Notably, both BU undergraduates and high school students rated the opportunities for interaction with eachother among the best aspects of RoBOT. On a scale of 1 to 10, BU undergraduates rated the following four categories highest

  3. Significance of Anti-Ro-52 kDa and SSA Antibodies in Patients with Autoimmune Diseases%抗Ro-52抗体与抗SSA抗体在自身免疫病中的检测意义

    Institute of Scientific and Technical Information of China (English)

    金燕萍; 林贵高; 阎超; 鄢盛恺

    2011-01-01

    Objective To investigate the clinical correlation of anti-Ro-52 and SSA antibody and to determine the clinical diagnostic value of anti-Ro-52/SSA in Chinese patients presenting with SLE,SS and other autoimmune diseases. Methods Serum samples from 50 patients with SLE, 50 with SS and 30 other autoimmune diseases were tested for the presence of anti-Ro-52 and anti-SSA using a commercial WB kit, AN A were tested by IIF,50 health people serum as controls. Results The positive rate of anti-Ro-52 and SSA in patients with SLE were 60% and 64% respectively,patients with SS were 72% and 82% respectively,patients with other autoimmune diseases were 30% and 23. 33% respectively,higher than control group (6%),and with X2 inspection,the difference was statistically significant (P<0. 05). Conclusion High prevalence of anti-Ro-52 and SSA is of significance in diagnosis of SLE and SS,the relationship between the two needs to be further explored.%目的 探讨抗Ro-52 kDa自身抗体与抗SSA抗体的关系及其在中国人群中SLE和SS等自身免疫病的诊断价值.方法 收集自身免疫病患者血清,其中SLE 50例,SS 50例,其他自身免疫病30例,50例健康者血清作为对照,用免疫印迹法检测所有标本中抗Ro-52与抗SSA抗体,同时用间接免疫荧光法检测所有标本ANA核型.结果 抗Ro-52和抗SSA抗体阳性率在SLE患者中分别为60%和64%,在SS中分别为72%和82%,在其他自身免疫病患者中分别为30%和23.33%,均高于健康对照组(6%),经χ2检验,差异有统计学意义(P<0.05).结论 抗Ro-52和抗SSA抗体阳性对诊断SLE和SS有一定的临床价值,二者的确切关系还需进一步探讨.

  4. Transiting exoplanets from the CoRoT space mission XXVIII. CoRoT-28b, a planet orbiting an evolved star, and CoRoT-29b, a planet showing an asymmetric transit

    CERN Document Server

    Cabrera, J; Montagnier, G; Fridlund, M; Eiff, M Ammler-von; Chaintreuil, S; Damiani, C; Deleuil, M; Ferraz-Mello, S; Ferrigno, A; Gandolfi, D; Guillot, T; Guenther, E W; Hatzes, A; Hébrard, G; Klagyivik, P; Parviainen, H; Pasternacki, Th; Pätzold, M; Sebastian, D; Santos, M Tadeu dos; Wuchterl, G; Aigrain, S; Alonso, R; Almenara, J -M; Armstrong, J D; Auvergne, M; Baglin, A; Barge, P; Barros, S C C; Bonomo, A S; Bordé, P; Bouchy, F; Carpano, S; Chaffey, C; Deeg, H J; Díaz, R F; Dvorak, R; Erikson, A; Grziwa, S; Korth, J; Lammer, H; Lindsay, C; Mazeh, T; Moutou, C; Ofir, A; Ollivier, M; Pallé, E; Rauer, H; Rouan, D; Samuel, B; Santerne, A; Schneider, J

    2015-01-01

    Context. We present the discovery of two transiting extrasolar planets by the satellite CoRoT. Aims. We aim at a characterization of the planetary bulk parameters, which allow us to further investigate the formation and evolution of the planetary systems and the main properties of the host stars. Methods. We used the transit light curve to characterize the planetary parameters relative to the stellar parameters. The analysis of HARPS spectra established the planetary nature of the detections, providing their masses. Further photometric and spectroscopic ground-based observations provided stellar parameters (log g,Teff,v sin i) to characterize the host stars. Our model takes the geometry of the transit to constrain the stellar density into account, which when linked to stellar evolutionary models, determines the bulk parameters of the star. Because of the asymmetric shape of the light curve of one of the planets, we had to include the possibility in our model that the stellar surface was not strictly spherical...

  5. 3D visualization of the internal nanostructure of polyamide thin films in RO membranes

    KAUST Repository

    Pacheco Oreamuno, Federico

    2015-11-02

    The front and back surfaces of fully aromatic polyamide thin films isolated from reverse osmosis (RO) membranes were characterized by TEM, SEM and AFM. The front surfaces were relatively rough showing polyamide protuberances of different sizes and shapes; the back surfaces were all consistently smoother with very similar granular textures formed by polyamide nodules of 20–50 nm. Occasional pore openings of approximately the same size as the nodules were observed on the back surfaces. Because traditional microscopic imaging techniques provide limited information about the internal morphology of the thin films, TEM tomography was used to create detailed 3D visualizations that allowed the examination of any section of the thin film volume. These tomograms confirmed the existence of numerous voids within the thin films and revealed structural characteristics that support the water permeance difference between brackish water (BWRO) and seawater (SWRO) RO membranes. Consistent with a higher water permeance, the thin film of the BWRO membrane ESPA3 contained relatively more voids and thinner sections of polyamide than the SWRO membrane SWC3. According to the tomograms, most voids originate near the back surface and many extend all the way to the front surface shaping the polyamide protuberances. Although it is possible for the internal voids to be connected to the outside through the pore openings on the back surface, it was verified that some of these voids comprise nanobubbles that are completely encapsulated by polyamide. TEM tomography is a powerful technique for investigating the internal nanostructure of polyamide thin films. A comprehensive knowledge of the nanostructural distribution of voids and polyamide sections within the thin film may lead to a better understanding of mass transport and rejection mechanisms in RO membranes.

  6. Variability in the CO ro-vibrational lines from HD163296

    Science.gov (United States)

    Hein Bertelsen, Rosina P.; Kamp, I.; van der Plas, G.; van den Ancker, M. E.; Waters, L. B. F. M.; Thi, W.-F.; Woitke, P.

    2016-05-01

    We present for the first time a direct comparison of multi-epoch (2001-2002 and 2012) CO ro-vibrational emission lines from HD 163296. We find that both the line shapes and the FWHM (full width at half-maximum) differ between these two epochs. The FWHM of the median observed line profiles are 10-25 km s-1 larger in the earlier epoch, and confirmed double peaks are only present in high J lines from 2001 to 2002. The line wings of individual transitions are similar in the two epochs making an additional central component in the later epoch a likely explanation for the single peaks and the lower FWHM. Variations in near-infrared brightness have been reported and could be linked to the observed variations. Additionally, we use the thermo-chemical disc code PRODIMO to compare for the first time the line shapes, peak separations, FWHM, and line fluxes, to those observed. The PRODIMO model reproduces the peak separations, and low and mid J line fluxes well. The FWHM however, are overpredicted and high J line fluxes are underpredicted. We propose that a variable non-Keplerian component of the CO ro-vibrational emission, such as a disc wind or an episodic accretion funnel, is causing the difference between the two data sets collected at different epochs, and between model and observations. Additional CO ro-vibrational line detections (with cryogenic high-resolution infrared echelle spectrograph/Very Large Telescope (VLT) or Near InfraRed SPECtrometer/Keck) or [Ne II] line observations with VLT Imager and Spectrometer for mid Infrared/VLT could help to clarify the cause of the variability.

  7. New RoF-PON architecture using polarization multiplexed wireless MIMO signals for NG-PON

    Science.gov (United States)

    Elmagzoub, M. A.; Mohammad, Abu Bakar; Shaddad, Redhwan Q.; Al-Gailani, Samir A.

    2015-06-01

    Next-generation access networks require provision of wireless services and high data rate to meet the huge demands for mobility and multiple services. Moreover, reusing the currently deployed optical distribution networks (ODNs) is highly beneficial and cost effective for providing the new high data rate wireless demands. In this paper, bidirectional radio over fiber passive optical network (RoF-PON) capable of handling multiple-input-multiple-output (MIMO) streams at low cost, high spectral efficiency and backward compatibility with currently deployed PON, is proposed. To the best of our knowledge, all the existing RoF MIMO solutions have not considered compatibility with currently deployed ODNs. Eight laser diodes (LDs) at the central office (CO) are enough for the whole system, instead of having LD or optical transmitter at each remote antenna unit (RAU), which makes a colorless and cost-effective RAU. Twenty four wavelengths are generated using optical comb technique. Each two 16-QAM MIMO signals that have the same carrier frequency in the downstream (DS) transmission are optically combined using polarization-division-multiplexing (PDM), where each two upstream (US) MIMO signals are time division multiplexed. The PDM configuration doubles spectral efficiency with a power penalty of only 1.5 dB. The proposed architecture is a bidirectional asymmetric RoF-PON with total 40/10 Gb/s for DS/US transmission. Even after transmission over 20 km SMF and splitting ratio of 32, acceptable transmission performance and widely separated constellation diagrams for the 16-QAM signals are achieved, with bit error rate (BER) of 10-6 for DS signals and 10-3 for the US signals which can be reduced down to 10-6 by using forward error correction (FEC).

  8. Application of first stage RO-EDI process in purified water preparation for pharmaceutical industry%一级RO-EDI工艺在制药纯化水制备中的应用

    Institute of Scientific and Technical Information of China (English)

    尤璐

    2016-01-01

    A pharmaceutical company in Tianjin city using municipal tap water as raw water to prepare purified water by process of filtration-softening-RO-EDI-circulating sterilization. After two years of field opera-tion, both of the desalination rates of RO device and EDI device could still reach about 97%, the water output flow was stable, and the product water quality met the requirement of purified water for pharmaceutical industry. It could be seen that, in the field of purified water preparation for pharmaceutical industry, first stage RO-EDI process had advantages of good treatment effect, stable operation, low running cost, and so on.%天津市某医药公司以自来水为水源, 采用过滤-软化-RO-EDI-循环杀菌的方式制取纯化水. 经过2年的现场运行, RO装置和EDI装置的脱盐率依然能达到97%左右, 产水量稳定, 产水水质满足制药纯化水要求,一级RO-EDI工艺在制药行业纯化水制备中具有处理效果好、 运行稳定、 运行成本低等优点.

  9. AN OVERVIEW OF THE IMPACT OF pH ON THE RO/NF MEMBRANE'S MASS TRANSFER%Ph对RO/NF膜传质影响的研究进展

    Institute of Scientific and Technical Information of China (English)

    潘斯源; 裘俊红; 周勇; 高从堦

    2011-01-01

    pH会改变RO/NF膜表面的荷电性质和孔径大小,还会通过影响溶质的存在形式来影响溶质与RO/NF膜的相互作用,所以pH会对RO/NF膜的膜材料及其水通量和截留率产生重要影响.由于这些影响的机理比较复杂,所以这一课题一直是国际上的研究热点,国内外对此已有许多报道.本文综述了pH对RO/NF膜传质影响的研究进展,并展望了pH对NF.RO膜传质影响的模型研究.%pH not only influences on the membrane surface charge properties and pore size., but also can influence the interaction between RO / NF membrane and solute by changing the solute's existence form.So pH has an important impact on the membrane materials as well as their water flux and retention.Because the impact is very complex, so this topic is always the hot spots of international research.and there have been a large number of domestic and foreign reports about that.This paper reviews the progress of experiments of the international research on this subject.

  10. The research on the application of MBR-RO process in wastewater treatment%M BR -RO 组合工艺在废水处理中的应用研究进展

    Institute of Scientific and Technical Information of China (English)

    张文华; 安洲; 龙北生; 刘红波; 康华; 刘鹏

    2015-01-01

    The combination of MBR and RO technology has led to a new focus on wastewater treatment . The article describes the characteristics of MBR‐RO technology .The present situation of MBR‐RO process application in wastewater treatment are summarized ,including municipal sewage ,garbage leachate ,print‐ing and dyeing wastewater ,coal coking wastewater ,semiconductor wastewater ,and chemical wastewater . Furthermore ,it also points out the existing problems in the application and research of MBR‐RO process . Finally ,this paper prospects the development tendency of MBR‐RO process .%膜生物反应器(MBR)与反渗透(RO)的组合工艺已成为废水处理中的新热点。对MBR -RO组合工艺进行了介绍,并对组合工艺近年来在市政污水、垃圾渗滤液、印染废水、煤焦化废水、半导体废水和化工废水等废水处理中的应用以及研究成果进行了综述,进而指出了 MBR -RO在应用研究过程中存在的问题,最后对其应用前景作了展望。

  11. Transiting exoplanets from the CoRoT space mission XIV. CoRoT-11b: a transiting massive "hot-Jupiter" in a prograde orbit around a rapidly rotating F-type star

    CERN Document Server

    Gandolfi, D; Alonso, R; Deleuil, M; Guenther, E W; Fridlund, M; Endl, M; Eigmüller, P; Csizmadia, Sz; Havel, M; Aigrain, S; Auvergne, M; Baglin, A; Barge, P; Bonomo, A S; Bordé, P; Bouchy, F; Bruntt, H; Cabrera, J; Carpano, S; Carone, L; Cochran, W D; Deeg, H J; Dvorak, R; Eislöffel, J; Erikson, A; Ferraz-Mello, S; Gazzano, J -C; Gibson, N P; Gillon, M; Gondoin, P; Guillot, T; Hartmann, M; Hatzes, A; Jorda, L; Kabath, P; Léger, A; Llebaria, A; Lammer, H; MacQueen, P J; Mayor, M; Mazeh, T; Moutou, C; Ollivier, M; Pätzold, M; Pepe, F; Queloz, D; Rauer, H; Rouan, D; Samuel, B; Schneider, J; Stecklum, B; Tingley, B; Udry, S; Wuchterl, G; 10.1051/0004-6361/201015132

    2010-01-01

    The CoRoT exoplanet science team announces the discovery of CoRoT-11b, a fairly massive hot-Jupiter transiting a V=12.9 mag F6 dwarf star (M*=1.27 +/- 0.05 Msun, R*=1.37 +/- 0.03 Rsun, Teff=6440 +/- 120 K), with an orbital period of P=2.994329 +/- 0.000011 days and semi-major axis a=0.0436 +/- 0.005 AU. The detection of part of the radial velocity anomaly caused by the Rossiter-McLaughlin effect shows that the transit-like events detected by CoRoT are caused by a planet-sized transiting object in a prograde orbit. The relatively high projected rotational velocity of the star (vsini=40+/-5 km/s) places CoRoT-11 among the most rapidly rotating planet host stars discovered so far. With a planetary mass of mp=2.33+/-0.34 Mjup and radius rp=1.43+/-0.03 Rjup, the resulting mean density of CoRoT-11b (rho=0.99+/-0.15 g/cm^3) can be explained with a model for an inflated hydrogen-planet with a solar composition and a high level of energy dissipation in its interior.

  12. Evaluation of TEG(®) and RoTEM(®) inter-changeability in trauma patients

    DEFF Research Database (Denmark)

    Hagemo, Jostein S; Næss, Paal A; Johansson, Pär;

    2013-01-01

    using. Spearman's rank correlation coefficient. Agreement was evaluated by Bland-Altman plots and calculation of limits of agreement. RESULTS: The mean ISS in the total population was 17, and the mortality was 16.5%. Mean base excess was -2.8 (SD: 4.2). The correlation coefficient for corresponding...... centres except for MA/MCF in one centre (Copenhagen). Generally, correlation coefficients were lower and agreement poorer in the one centre (Oslo) where measurements were performed bedside by clinicians. CONCLUSION: Inter-changeability between TEG(®) and RoTEM(®) is limited in the trauma setting...

  13. Rotation period distribution of CoRoT and Kepler Sun-like stars

    Science.gov (United States)

    Leão, I. C.; Pasquini, L.; Ferreira Lopes, C. E.; Neves, V.; Valcarce, A. A. R.; de Oliveira, L. L. A.; Freire da Silva, D.; de Freitas, D. B.; Canto Martins, B. L.; Janot-Pacheco, E.; Baglin, A.; De Medeiros, J. R.

    2015-10-01

    Aims: We study the distribution of the photometric rotation period (Prot), which is a direct measurement of the surface rotation at active latitudes, for three subsamples of Sun-like stars: one from CoRoT data and two from Kepler data. For this purpose, we identify the main populations of these samples and interpret their main biases specifically for a comparison with the solar Prot. Methods: Prot and variability amplitude (A) measurements were obtained from public CoRoT and Kepler catalogs, which were combined with public data of physical parameters. Because these samples are subject to selection effects, we computed synthetic samples with simulated biases to compare with observations, particularly around the location of the Sun in the Hertzsprung-Russel (HR) diagram. Publicly available theoretical grids and empirical relations were used to combine physical parameters with Prot and A. Biases were simulated by performing cutoffs on the physical and rotational parameters in the same way as in each observed sample. A crucial cutoff is related with the detectability of the rotational modulation, which strongly depends on A. Results: The synthetic samples explain the observed Prot distributions of Sun-like stars as having two main populations: one of young objects (group I, with ages younger than ~1 Gyr) and another of main-sequence and evolved stars (group II, with ages older than ~1 Gyr). The proportions of groups I and II in relation to the total number of stars range within 64-84% and 16-36%, respectively. Hence, young objects abound in the distributions, producing the effect of observing a high number of short periods around the location of the Sun in the HR diagram. Differences in the Prot distributions between the CoRoT and Kepler Sun-like samples may be associated with different Galactic populations. Overall, the synthetic distribution around the solar period agrees with observations, which suggests that the solar rotation is normal with respect to Sun

  14. RO-75: a FORTRAN code for calculation and design optimization of reverse osmosis seawater desalination plants

    Energy Technology Data Exchange (ETDEWEB)

    Glueckstern, P.; Reed, S.A.; Wilson, J.V.

    1976-11-01

    The reverse osmosis process has been used extensively for the conversion of brackish waters to potable water. The process is now nearing commercialization as a means for the conversion of seawater. The computer program (RO-75) is a Fortran code for the optimizatin of the design and economics of seawater reverse osmosis plants. The examples described are based on currently available, commercial membrane modules and prevailing prices. However, the code is very flexible and can be used to optimize plants utilizing future technological improvements and different economic parameters.

  15. Rapid-Adiabatic Control of Ro-Vibrational Populations in Polyatomic Molecules

    Science.gov (United States)

    Zak, Emil J.; Yachmenev, Andrey

    2017-06-01

    We present a simple method for control of ro-vibrational populations in polyatomic molecules in the presence of inhomogeneous electric fields [1]. Cooling and trapping of heavy polar polyatomic molecules has become one of the frontier goals in high-resolution molecular spectroscopy, especially in the context of parity violation measurement in chiral compounds [2]. A key step toward reaching this goal would be development of a robust and efficient protocol for control of populations of ro-vibrational states in polyatomic, often floppy molecules. Here we demonstrate a modification of the stark-chirped rapid-adiabatic-passage technique (SCRAP) [3], designed for achieving high levels of control of ro-vibrational populations over a selected region in space. The new method employs inhomogeneous electric fields to generate space- and time- controlled Stark-shifts of energy levels in molecules. Adiabatic passage between ro-vibrational states is enabled by the pump pulse, which raises the value of the Rabi frequency. This Stark-chirped population transfer can be used in manipulation of population differences between high-field-seeking and low-field-seeking states of molecules in the Stark decelerator [4]. Appropriate timing of voltages on electric rods located along the decelerator combined with a single pump laser renders our method as potentially more efficient than traditional Stark decelerator techniques. Simulations for NH_3 show significant improvement in effectiveness of cooling, with respect to the standard 'moving-potential' method [5]. At the same time a high phase-space acceptance of the molecular packet is maintained. E. J. Zak, A. Yachmenev (submitted). C. Medcraft, R. Wolf, M. Schnell, Angew. Chem. Int. Ed., 53, 43, 11656-11659 (2014) M. Oberst, H. Munch, T. Halfman, PRL 99, 173001 (2007). K. Wohlfart, F. Grätz, F. Filsinger, H. Haak, G. Meijer, J. Küpper, Phys. Rev. A 77, 031404(R) (2008). H. L. Bethlem, F. M. H. Crompvoets, R. T. Jongma, S. Y. T. van de

  16. Transverse Myelitis Associated with Anti-Ro (SSA) Autoantibodies: A Record of Two Cases.

    Science.gov (United States)

    Melikyan, G; Abdelrahman, M H; D'Suoza, A; Akhtar, N; Elzouki, A N; Hammoudeh, M

    2012-01-01

    Transverse myelitis (TM) is an inflammatory process involving a restricted area of the spinal cord. The usual dramatic presentation makes TM a medical emergency. Early detection and aggressive therapy are required in order to improve the prognosis. The association of this unique clinical phenotype and autoantibody provides circumstantial evidence that an autoimmune aetiology might be involved. We describe two cases of TM associated with anti-Ro (SSA) autoantibodies without connective tissue disease manifestations. The two patients were treated successfully with IV steroids and cyclophosphamide.

  17. RoF技术在无线接入网络中的应用%The Implementation of the ROF Technology in the Wireless Access Network

    Institute of Scientific and Technical Information of China (English)

    曹培炎

    2005-01-01

    从无线接入网需要的角度入手,总结了以RoF(Radio over Fiber)技术为核心的系统的发展过程,分析了RoF系统结构设计的基本思想及关键的实现技术,对RoF技术的应用作了介绍,并对前景做了展望.

  18. Measurements of tropospheric HO2 and RO2 by oxygen dilution modulation and chemical ionization mass spectrometry

    Directory of Open Access Journals (Sweden)

    J. S. Olson

    2010-09-01

    Full Text Available An improved method for the measurement of hydroperoxy radicals (HO2 and organic peroxy radicals (RO2, where R is any organic group has been developed that combines two previous chemical conversion/chemical ionization mass spectrometry (CIMS peroxy radical measurement techniques. Applicable to both ground-based and aircraft platforms, the method provides good separation between HO2 and RO2 and frequent measurement capability with observations of both HO2 and HO2 + RO2 amounts each minute. This allows for analyses of measured [HO2]/[HO2 + RO2] ratios on timescales relevant to tropospheric photochemistry. By varying both [NO] and [O2] simultaneously in the chemical conversion region of the PeRCIMS (Peroxy Radical CIMS inlet, the method exploits the changing conversion efficiency of RO2 to HO2 under different inlet [NO]/[O2] to selectively observe either primarily HO2 or the sum of HO2 and RO2. Two modes of operation have been established for ambient measurements: in the first half of the minute, RO2 radicals are measured at close to 100% efficiency along with HO2 radicals (low [NO]/[O2] = 2.53 × 10−5 and in the second half of the minute, HO2 is detected while the majority of ambient RO2 radicals are measured with approximately 15% efficiency (high [NO]/[O2] = 6.80 × 10−4. The method has been tested extensively in the laboratory under various conditions and for a variety of organic peroxy radicals relevant to the atmosphere and the results of these tests are presented. The modified PeRCIMS instrument has been deployed successfully using the current measurement technique on a number of aircraft campaigns, including on the NSF/NCAR C-130 during the MIRAGE-Mex and NASA INTEX-B field campaigns in the spring of 2006. A brief comparison of the peroxy radical measurements during these campaigns to a photochemical box model confirms that the PeRCIMS is able to successfully separate and measure HO2 and RO2 under the majority of tropospheric conditions.

  19. 符合RoHS禁令的厚膜金导体浆料%Performance of RoHS Compliant Thick Film Gold Conductor

    Institute of Scientific and Technical Information of China (English)

    Samson Shahbazi; Peter Bokalo; David Malanga; Meg Tredinnick; Jim Wood

    2006-01-01

    There is an increased demand from the electronic and hybrid circuit manufactures to restrict the use of lead and cadmium and other hazardous substances from their products due to health and environmental issues. With the pending implementation of the European Union directive (Restriction of Hazardous Substances) banning the use of these substances, effective Ⅰ July 2006, circuit manufacturers are eager to find replacements for their existing materials which contain lead and cadmium. It is well documented that cadmium oxide is an excellent adhesion promoter in thick film gold paste. Gold thick film pastes are primarily used in high reliability applications such as medical devices, military applications and high frequency circuits. The challenge is to develop a gold conductor formulation with the same performance and properties as classic cadmium containing formulations. Heraeus has been proactive for the past decade in the development of thick film products that are both lead and cadmium free. To date, Heraeus has developed and introduced into the market many environmentally friendly thick film products.This paper discusses the results of a newly developed thick film gold conductor paste for use in a wide variety of applications. Wire bonding data will be presented, with both gold and aluminum wire,on top of both 96% A12O3 and dielectric substrates with reliability results. Data will show compatibility between the lead and cadmium free gold conductor and a variety of RoHS compliant solderable conductors to allow for its use in mixed metallurgy circuits.%出于对健康和环境的考虑,限制铅、镉和含有其它有毒物质在混合集成电路产品应用的需求越来越大.根据2006年7月1日生效的欧盟禁令(即RoHS)这些物质是禁用的,电路生产商急于找到可以替换现有含铅和镉的产品.镉氧化物在厚膜金浆料中可以起到很好的粘附作用.金厚膜浆料主要用于要求高机械强度的领域,比如医疗器

  20. Pharmacokinetic-pharmacodynamic modeling of the relationship between D2 receptor occupancy and catalepsy in rats : Predicting extrapyramidal side effects in humans

    NARCIS (Netherlands)

    Johnson, Martin; Kozielska, Magdalena; Pilla Reddy, Venkatesh; Vermeulen, An; Barton, Hugh A.; Grimwood, Sarah; de Greef, Rik; Groothuis, Genoveva; Danhof, Meindert; Proost, Johannes

    2012-01-01

    Objectives: Dopamine D2 receptor occupancy (D2RO) is the major determinant of efficacy and safety in schizophrenia drug therapy (1,2). Excessive D2RO (>80 %) is known to cause catalepsy (CAT) in rats and extrapyramidal side effects (EPS) in human(3). The relationship between CAT scores in rats and E

  1. Li and Ag Co-Doped ZnO Photocatalyst for Degradation of RO 4 Dye Under Solar Light Irradiation.

    Science.gov (United States)

    Dhatshanamurthi, P; Shanthi, M

    2016-06-01

    The synthesis of Li doped Ag-ZnO (Li-Ag-ZnO) has been successfully achieved by a sonochemically assisted precipitation-decomposition method. The synthesized catalyst was characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), field emission scanning electron microscopy (FE-SEM), energy dispersive spectroscopy (EDS), diffuse reflectance spectra (DRS), photoluminescence spectra (PL), X-ray photoelectron spectra (XPS) and BET surface area measurements. The photocatalytic activity of Li-Ag-ZnO was investigated for the degradation of Reactive orange 4 (RO 4) dye in aqueous solution under solar light irradiation. Co-dopants shift the absorbance of ZnO to the visible region. Li-Ag-ZnO is found to be more efficient than Ag-ZnO, Li-ZnO, commercial ZnO and prepared ZnO at pH 7 for the mineralization of RO 4 dye under solar light irradiation. The influences of operational parameters such as the amount of photocatalyst, dye concentration, initial pH on photo-mineralization of RO 4 have been analyzed. The mineralization of RO 4 dye has been confirmed by COD measurements. A degradation mechanism is proposed for the degradation of RO 4 under solar light. The catalyst was found to be more stable and reusable.

  2. HD 174884: a strongly eccentric, short-period early-type binary system discovered by CoRoT

    CERN Document Server

    Maceroni, C; Michel, E; Harmanec, P; Prsa, A; Briquet, M; Niemczura, E; Morel, T; Ladjal, D; Auvergne, M; Baglin, A; Baudin, F; Catala, C; Samadi, R; Aerts, C

    2009-01-01

    Accurate photometric CoRoT space observations of a secondary seismological target, HD 174884, led to the discovery that this star is an astrophysically important double-lined eclipsing spectroscopic binary in an eccentric orbit (e of about 0.3), unusual for its short (3.65705d) orbital period. The high eccentricity, coupled with the orientation of the binary orbit in space, explains the very unusual observed light curve with strongly unequal primary and secondary eclipses having the depth ratio of 1-to-100 in the CoRoT 'seismo' passband. Without the high accuracy of the CoRoT photometry, the secondary eclipse, 1.5 mmag deep, would have gone unnoticed. A spectroscopic follow-up program provided 45 high dispersion spectra. The analysis of the CoRoT light curve was performed with an adapted version of PHOEBE that supports CoRoT passbands. The final solution was obtained by simultaneous fitting of the light and the radial velocity curves. Individual star spectra were derived by spectrum disentangling. The uncerta...

  3. Hemodialysis Reliable Outflow (HeRO) device in end-stage dialysis access: a decision analysis model.

    Science.gov (United States)

    Dageforde, Leigh Anne; Bream, Peter R; Moore, Derek E

    2012-09-01

    The Hemodialysis Reliable Outflow (HeRO) dialysis access device is a permanent tunneled dialysis graft connected to a central venous catheter and is used in patients with end-stage dialysis access (ESDA) issues secondary to central venous stenosis. The safety and effectiveness of the HeRO device has previously been proven, but no study thus far has compared the cost of its use with tunneled dialysis catheters (TDCs) and thigh grafts in patients with ESDA. A decision analytic model was developed to simulate outcomes for patients with ESDA undergoing placement of a HeRO dialysis access device, TDC, or thigh graft. Outcomes of interest were infection, thrombosis, and ischemic events. Baseline values, ranges, and costs were determined from a systematic review of the literature. Total costs were based on 1 year of post-procedure outcomes. Sensitivity analyses were conducted to test model strength. The HeRO dialysis access device is the least costly dialysis access with an average 1-year cost of $6521. The 1-year cost for a TDC was $8477. A thigh graft accounted for $9567 in a 1-year time period. The HeRO dialysis access device is the least costly method of ESDA. The primary determinants of cost in this model are infection in TDCs and leg ischemia necessitating amputation in thigh grafts. Further study is necessary to incorporate patient preference and quality of life into the model. Copyright © 2012 Elsevier Inc. All rights reserved.

  4. Subclinical Sjögren's syndrome and anti-Ro/SSA-positive autoimmune fatigue syndrome in children.

    Science.gov (United States)

    Itoh, Y; Imai, T; Fujino, O; Igarashi, T; Fukunaga, Y

    2002-09-01

    Abstract Although Sjögren's syndrome (SS) is quite rare among children, subclinical conditions without any sicca symptoms have been reported. This condition is characterized by nonspecific rheumatic symptoms and histopathological findings in salivary glands which are equivalent to SS. Many children with subclinical SS are positive for anti-Ro/SSA. On the other hand, autoimmune fatigue syndrome (AIFS) is characterized by chronic nonspecific complaints and positive antinuclear antibodies, with or without fulfilling the criteria for chronic fatigue syndrome. Although a novel autoantibody against a 62 kD nuclear protein (anti-Sa) is detected in about 40% of AIFS patients, few marker antibodies for autoimmune diseases, such as anti-DNA, anti-Sm, anti-U1-ribonucleoprotein (RNP), or anticardiolipin, are found in AIFS patients. In this study, however, anti-Ro/SSA was detected in sera from 8 out of 122 AIFS patients. Seven of the 8 anti-Ro/SSA-positive patients were female. All 8 patients had fatigue and low-grade fever, but none complained of xerosis. Western immunoblot analysis revealed that 7 sera reacted with Ro52, and that none was positive for anti-La/SSB or anti-Sa. Two of the 8 patients had histories of recurrent parotitis. Lip biopsies showed mild chronic inflammation compatible with subclinical SS in these 2 patients, although the other 6 patients had no abnormal histopathology. Thus, at least some anti-Ro/SSA-positive patients could be diagnosed as having SS.

  5. Luminous intensity bilateral comparison using lamps as transfer standards between LNE (France) and INM-RO (Roumania)

    Science.gov (United States)

    Obein, G.; Simionescu, M.; Dubard, J.; Seucan, A.; Bastie, J.

    2017-01-01

    The EUROMET project 823, "Comparison of luminous intensity and luminous flux using lamps as transfer standards" between LNE (formerly BNM), France, and INM-RO, Romania, has linked the INM-RO real-ized candela to the CCPR key comparison reference values. The comparison was registered on BIPM key comparison data base with the numbers EUROMET.PR-K3.a.1. The comparison has been piloted by LNE. It has been carried out by successive calibrations of a group of four travelling standard lamps in the two laboratories. The lamps were first calibrated by INM-RO, then cal-ibrated by LNE and calibrated by INM-RO in order to check for any drift or instability. The measurements have been performed over the period November 2004 to June 2006. According to the results of the comparison, the Degree of Equivalence of the candela realized by INM-RO to the Key Comparison Reference Value of CCPR-K3 is - 0,72 % with an expended uncertainty (k = 2) of 2.14 %. Main text To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCPR, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).

  6. CoRoT-10b: a giant planet in a 13.24 day eccentric orbit

    CERN Document Server

    Bonomo, A S; Alonso, R; Gazzano, J -C; Havel, M; Aigrain, S; Auvergne, M; Baglin, A; Barbieri, M; Barge, P; Benz, W; Bordé, P; Bouchy, F; Bruntt, H; Cabrera, J; Cameron, A C; Carone, L; Carpano, S; Csizmadia, Sz; Deleuil, M; Deeg, H J; Dvorak, R; Erikson, A; Ferraz-Mello, S; Fridlund, M; Gandolfi, D; Gillon, M; Guenther, E; Guillot, T; Hatzes, A; Hébrard, G; Jorda, L; Lammer, H; Lanza, A F; Léger, A; Llebaria, A; Mayor, M; Mazeh, T; Moutou, C; Ollivier, M; Pätzold, M; Pepe, F; Queloz, D; Rauer, H; Rouan, D; Samuel, B; Schneider, J; Tingley, B; Udry, S; Wuchterl, G

    2010-01-01

    The space telescope CoRoT searches for transiting extrasolar planets by continuously monitoring the optical flux of thousands of stars in several fields of view. We report the discovery of CoRoT-10b, a giant planet on a highly eccentric orbit (e=0.53 +/- 0.04) revolving in 13.24 days around a faint (V=15.22) metal-rich K1V star. We use CoRoT photometry, radial velocity observations taken with the HARPS spectrograph, and UVES spectra of the parent star to derive the orbital, stellar and planetary parameters. We derive a radius of the planet of 0.97 +/- 0.07 R_Jup and a mass of 2.75 +/- 0.16 M_Jup. The bulk density, rho_pl=3.70 +/- 0.83 g/cm^3, is ~2.8 that of Jupiter. The core of CoRoT-10b could contain up to 240 M_Earth of heavy elements. Moving along its eccentric orbit, the planet experiences a 10.6-fold variation in insolation. Owing to the long circularisation time, tau_circ > 7 Gyr, a resonant perturber is not required to excite and maintain the high eccentricity of CoRoT-10b.

  7. (Re)viver as roças: reabilitação participada das roças de São Tomé e Príncipe

    OpenAIRE

    Vicente, Marta Alexandra Gonçalves

    2016-01-01

    A investigação (Re)Viver as roças – Reabilitação participada das roças de São Tomé e Príncipe, surge no âmbito de uma dissertação de natureza científica, tendo como objetivo central o desenho e implementação de uma primeira fase de um processo participado de reabilitação das roças, promovendo o envolvimento direto e ativo das comunidades locais nos processos de tomada de decisões sobre o espaço que habitam. O tema surge como uma oportunidade de procurar uma resposta para o atual e...

  8. 1400客/2000米客滚船的结构设计分析%Structural Design and Analysis of 1400-Passenger/2000-Meter Ro/Ro Passenger Vessel

    Institute of Scientific and Technical Information of China (English)

    王艳春; 张新伟

    2012-01-01

    Key points of structural design of the 1400-passenger / 2000-meter Ro/Ro passenger vessel are introduces in the paper, including the hull girder longitudinal strength and stability, the structure arrangement, the arrangement and supporting structure of Ro/Ro equipments. Through the FEMstrength analysis of the ship, locations of high stress are strengthened and structures of lower stress are minimized with reasonable redundant stress level. The modification of structure is done according to the vibration analysis, which ensures the hospitality of the vessel. The vessel is already in service with excellent status. The article would be helpful for the future design of Ro/Ro passenger vessels.%主要介绍1400客/2000米客滚船的结构设计要点,包括总纵强度和稳性,结构布置,以及滚装设备的布置和加强.通过对该船的有限元强度分析对应力过大处结构进行加强,对应力较小处进行精简.做到应力均衡.通过对该船的振动分析,修改结构,保证了其作为客船的舒适性.该船已营运,营运状况良好.希望这些设计要点对后续的客滚船设计具有一定的指导和借鉴作用.

  9. The transiting exoplanet CoRoT-11b and its peculiar tidal evolution

    Directory of Open Access Journals (Sweden)

    Damiani C.

    2011-02-01

    Full Text Available CoRoT-11b is a fairly massive hot-Jupiter (Mp = 2.33 ± 0.34 MJup in a 3 days orbit around a F6 V star with an age of 2 ± 1 Gyr. The relatively high projected rotational velocity of the star (v sin i⋆ = 40 ± 5 km/s places CoRoT-11 among the most rapidly rotating planet hosting stars discovered so far. Assuming that the star is seen equator-on, the v sin i⋆ and the star radius (R∗ = 1.37±0.03 R⊙ translate into a stellar rotation period of 1.73±0.26 days. This peculiar planet/star configuration offers an unique opportunity to study the tidal evolution of the system. Owing to the strong tidal interaction, the planet would have moved outwards, from a starting semi-major axis corresponding to an orbital period almost synchronized with the stellar rotation. We found that the present value of the tidal quality factor Q′s could be measured by a timing of the mid-epoch of the transits to be observed with an accuracy of about 0.5 − 1 seconds over a time baseline of about 25 years.

  10. The roAp star $\\alpha$ Circini as seen by BRITE-Constellation

    CERN Document Server

    Weiss, W W; Pigulski, A; Popowicz, A; Huber, D; Kuschnig, R; Moffat, A F J; Matthews, J M; Saio, H; Schwarzenberg-Czerny, A; Grant, C C; Koudelka, O; Lüftinger, T; Rucinski, S M; Wade, G A; Alves, J; Guedel, M; Handler, G; Mochnacki, St; Orleanski, P; Pablo, B; Pamyatnykh, A; Ramiaramanantsoa, T; Rowe, J; Whittaker, G; Zawistowski, T; Zocłonska, E; Zwintz, K

    2016-01-01

    We report on an analysis of high-precision, multi-colour photometric observations of the rapidly-oscillating Ap (roAp) star $\\alpha$ Cir. These observations were obtained with the BRITE-Constellation, which is a coordinated mission of five nanosatellites that collects continuous millimagnitude-precision photometry of dozens of bright stars for up to 180 days at a time in two colours (Johnson B and R). BRITE stands for BRight Target Explorer. The object $\\alpha$ Cir is the brightest roAp star and an ideal target for such investigations, facilitating the determination of oscillation frequencies with high resolution. This star is bright enough for complementary interferometry and time-resolved spectroscopy. Four BRITE satellites observed $\\alpha$ Cir for 146 d or 33 rotational cycles. Phasing the photometry according to the 4.4790 d rotational period reveals qualitatively different light variations in the two photometric bands. The phased red-band photometry is in good agreement with previously-published WIRE da...

  11. The TROVE module: A common element in Telomerase, Ro and Vault ribonucleoproteins

    Directory of Open Access Journals (Sweden)

    Bateman Alex

    2003-10-01

    Full Text Available Abstract Background Ribonucleoproteins carry out a variety of important tasks in the cell. In this study we show that a number of these contain a novel module, that we speculate mediates RNA-binding. Results The TROVE module – Telomerase, Ro and Vault module – is found in TEP1 and Ro60 the protein components of three ribonucleoprotein particles. This novel module, consisting of one or more domains, may be involved in binding the RNA components of the three RNPs, which are telomerase RNA, Y RNA and vault RNA. A second conserved region in these proteins is shown to be a member of the vWA domain family. The vWA domain in TEP1 is closely related to the previously recognised vWA domain in VPARP a second component of the vault particle. This vWA domain may mediate interactions between these vault components or bind as yet unidentified components of the RNPs. Conclusions This work suggests that a number of ribonucleoprotein components use a common RNA-binding module. The TROVE module is also found in bacterial ribonucleoproteins suggesting an ancient origin for these ribonucleoproteins.

  12. Isolated Ro52 Antibodies as Immunological Marker of a Mild Phenotype of Undifferentiated Connective Tissue Diseases

    Science.gov (United States)

    Navarro-Gonzálvez, José Antonio; Rodríguez-Lozano, Beatriz

    2017-01-01

    The term undifferentiated connective tissue disease (UCTD) is used to describe undiagnosed patients that do not fulfill classification criteria for definite connective tissue disease (Systemic Lupus, Systemic Sclerosis, Sjögren Syndrome, and Dermatomyositis/Polymyositis). It is important to find serological markers as predictors of the evolution or severity of these diseases. The objective of this retrospective study was to investigate if there was a milder subgroup of UCTD with a special clinical profile consisting only in the presence of anti-Ro52 autoantibodies. Immunological and clinical records of 62 patients attending the hospital during 30 months were studied. Results showed a target population formed by mostly women, aged between 40 and 80 years at the moment of the study, with a registered age of onset between 40 and 60 years. Speckled pattern was the most frequent pattern found by indirect immunofluorescence. Given the obtained results and keeping in mind possible limitations because of sample size, isolated positive anti-Ro52 autoantibodies seem to lead to a benign effect in terms of evolution of the disease. As a future objective, the follow-up of these patients should be necessary to investigate new clinical symptoms, serological markers, or development of a definite connective tissue disease over time. PMID:28210273

  13. Isolated Ro52 Antibodies as Immunological Marker of a Mild Phenotype of Undifferentiated Connective Tissue Diseases

    Directory of Open Access Journals (Sweden)

    Ana Alonso-Larruga

    2017-01-01

    Full Text Available The term undifferentiated connective tissue disease (UCTD is used to describe undiagnosed patients that do not fulfill classification criteria for definite connective tissue disease (Systemic Lupus, Systemic Sclerosis, Sjögren Syndrome, and Dermatomyositis/Polymyositis. It is important to find serological markers as predictors of the evolution or severity of these diseases. The objective of this retrospective study was to investigate if there was a milder subgroup of UCTD with a special clinical profile consisting only in the presence of anti-Ro52 autoantibodies. Immunological and clinical records of 62 patients attending the hospital during 30 months were studied. Results showed a target population formed by mostly women, aged between 40 and 80 years at the moment of the study, with a registered age of onset between 40 and 60 years. Speckled pattern was the most frequent pattern found by indirect immunofluorescence. Given the obtained results and keeping in mind possible limitations because of sample size, isolated positive anti-Ro52 autoantibodies seem to lead to a benign effect in terms of evolution of the disease. As a future objective, the follow-up of these patients should be necessary to investigate new clinical symptoms, serological markers, or development of a definite connective tissue disease over time.

  14. Terahertz Initiatives at the Antarctic Submillimeter Telescope and Remote Observatory (AST/RO)

    CERN Document Server

    Stark, A A; Martin, C L; Chamberlin, R A; Kooi, J; Walker, C K; Stark, Antony A; Lane, Adair P.; Martin, Christopher L.; Chamberlin, Richard; Kooi, Jacob; Walker, Christopher K.

    2002-01-01

    The Antarctic Submillimeter Telescope and Remote Observatory (AST/RO) is a 1.7-meter diameter offset Gregorian instrument located at the NSF Amundsen-Scott South Pole Station. This site is exceptionally dry and cold, providing opportunities for Terahertz observations from the ground. Preliminary analysis of recent site testing results shows that the zenith transparency of the 1.5 THz atmospheric window at South Pole frequently exceeds 10% during the Austral winter. Routine observations at 810 GHz have been conducted over the past two years, resulting in large-scale maps of the Galactic Center region and measurements of the (13)C line in molecular clouds. During the next two years, the observatory plans to support two Terahertz instruments: 1) TREND (Terahertz Receiver with Niobium Nitride Device--K. S. Yngvesson, University of Massachusetts, P. I.), and 2) SPIFI (South Pole Imaging Fabry-Perot Interferometer--G. J. Stacey, Cornell University, P. I.). AST/RO could be used in future as an observational test bed...

  15. Observations of gas- and aerosol-phase organic nitrates at BEACHON-RoMBAS 2011

    Directory of Open Access Journals (Sweden)

    J. L. Fry

    2013-09-01

    Full Text Available At the Rocky Mountain Biogenic Aerosol Study (BEACHON-RoMBAS field campaign in the Colorado front range, July–August 2011, measurements of gas- and aerosol-phase organic nitrates enabled a study of the role of NOx (NOx = NO + NO2 in oxidation of forest-emitted volatile organic compounds (VOCs and subsequent aerosol formation. Substantial formation of peroxy- and alkyl-nitrates is observed every morning, with an apparent 2.9% yield of alkyl nitrates from daytime RO2 + NO reactions. Aerosol-phase organic nitrates, however, peak in concentration during the night, with concentrations up to 140 ppt as measured by both optical spectroscopic and mass spectrometric instruments. The diurnal cycle in aerosol fraction of organic nitrates shows an equilibrium-like response to the diurnal temperature cycle, suggesting some reversible absorptive partitioning, but the full dynamic range cannot be reproduced by thermodynamic repartitioning alone. Nighttime aerosol organic nitrate is observed to be positively correlated with [NO2] × [O3] but not with [O3]. These observations support the role of nighttime NO3-initiated oxidation of monoterpenes as a significant source of nighttime aerosol. Nighttime production of organic nitrates is comparable in magnitude to daytime photochemical production at this site, which we postulate to be representative of the Colorado front range forests.

  16. Design of mm-RoF System Based on OFM Technique with Optimized OFDM Modulation

    Institute of Scientific and Technical Information of China (English)

    林如俭,; 陈翔,; 张林,; 叶家骏,; 宋英雄,; 李迎春

    2012-01-01

    We present the design of a novel bi-directional millimeter-wave radio-over-fiber (mm-RoF) system based on the millimeter-wave generation by optical frequency multiplication (OFM).A dual-drive Mach-Zehnder modulator is used to generate high-order optical side-modes which beat in the photo-detector,producing a 40-GHz carrier.Over 100-Mb/s orthogonal frequency division multiplexing (OFDM) modulation scheme is employed.The emphasis is on developing a mathematical model for optimizing optical modulation index to the Mach-Zehnder intensity modulator (IM) for OFDM signal with high peak-to-average power ratio which imposes a limitation on the system bit error rate (BER) performance due to the non-linearity of IM.The theoretical analysis on conposite carrier to composite triple beat ratio is performed based on which extension to the system BER formula for quadrature phase shift keying/ multiple quadrature amplitude modulation (QPSK/MQAM) format is presented.The experimental proof is given in a 40-GHz RoF system at a bit rate of up to 280 Mb/s in 100-MHz bandwidth.

  17. Dramatic improvement of anti-SS-A/Ro-associated interstitial lung disease after immunosuppressive treatment.

    Science.gov (United States)

    Paola, Caramaschi; Giuliana, Festi; Giovanni, Orsolini; Cristian, Caimmi; Domenico, Biasi

    2016-07-01

    The aim of the study was to report three patients affected by interstitial lung disease associated with positive anti-SS-A/Ro autoantibody who showed a dramatic improvement after immunosuppressive treatment. Medical charts were reviewed to obtain clinical data, laboratory parameters, lung function tests, high-resolution computed tomography results and response to immunosuppressive treatment. The three patients showed a clinical picture of a lung-dominant connective tissue disease characterized by a sudden onset with dyspnea, cough and subtle extrathoracic features together with positive anti-SS-A/Ro antibody and weak titer antinuclear antibodies. All three patients responded favorably to immunosuppressive therapy: Two cases were treated with a combination of corticosteroid and cyclophosphamide followed by mycophenolate mofetil; in the third patient, clinical benefit was obtained after rituximab was added to corticosteroid and immunosuppressant drug. In spite of an abrupt onset with significant lung function impairment, all three patients had a favorable clinical response to immunosuppressive therapy. This report may be useful in making therapeutic decisions in case of interstitial lung disease associated with anti-SS-A antibody.

  18. Search of X-ray emission from roAp stars: The case of gamma Equulei

    CERN Document Server

    Stelzer, B; Schöller, M; Hubrig, S; Cowley, C

    2011-01-01

    The detection of X-ray emission from Ap stars can be an indicator for the presence of magnetic activity and dynamo action, provided different origins for the emission, such as wind shocks and close late-type companions, can be excluded. Here we report on results for gamma Equu, the only roAp star for which an X-ray detection is reported in ROSAT catalogs. We use high resolution imaging in X-rays with Chandra and in the near-infrared with NACO/VLT that allow us to spatially resolve companions down to ~1" and ~0.06" separations, respectively. The bulk of the X-ray emission is associated with a companion of gamma Equu identified in our NACO image. Assuming coevality with the primary roAp star (~900 Myr), the available photometry for the companion points at a K-type star with ~0.6 M_sun. Its X-ray properties are in agreement with the predictions for its age and mass. An excess of photons with respect to the expected background and contribution from the nearby companion is observed near the optical position of gam...

  19. Uniaxial stress study of the ro-vibrational transitions of HD in Si

    Science.gov (United States)

    Shi, G. A.

    2005-03-01

    The vibrational spectroscopy of interstitial H2 in Si gave rise to a number of perplexing puzzles that concerned the rotational motion of the defect [1]. Most experiments were interpreted in terms of a static defect whereas theory suggested that there should be a very small barrier to rotation. The position and intensity of the HD vibrational line were also anomalous. The key to the solution of these puzzles was the discovery of a new vibrational line for HD and the recognition that certain ro- vibrational transitions are possible for HD that are not possible for the H2 or D2 homonuclear molecules in Si. H2 in Si is a nearly free rotator after all. New experiments have been performed for HD in Si in which IR spectroscopy combined with uniaxial stress has been used to confirm the assignments of the ro-vibrational transitions of HD that underpin our understanding of H2 in Si. This work is supported by NSF Grant DMR 0403641. 1. M. Stavola, E E. Chen, W.B. Fowler, G.A. Shi, Physica B 340-342, 58 (2003), and references contained therein.

  20. Search for Exomoons and Rings with Kepler and CoRoT

    Science.gov (United States)

    Moretto Tusnski, Luis Ricardo; Silva Valio, Adriana

    2015-08-01

    After almost 20 years since the first exoplanet discoveries, new techniques have been developed and high precision has been achieved, which lead to a large number of small planets detected. Recently, some researchers are trying to detect exomoons: moons around exoplanets. Some methods have been proposed and studied, and the most likely to lead to a discovery is the planetary transit technique. Exomoons cause two types of effects in the planet transit light curve: photometric signatures and transit timing effects. Despite the searches and methods proposed, so far no moon has been found around exoplanets. One reason for this is the small number of searches been conducted. In this work, we present an independent serch project called PSER - Photometric Search for Exomoons and Rings. As the name states, this project looks for exomoons and exorings in Kepler and CoRoT lightcurves. To do so, we developed a program to look for exomoons signals automatically, using MCMC to fit the lightcurves. We started our search with Kepler and CoRoT confirmed single planets. After that, we will also look in Kepler Planetary Candidates. So far, no signal has been found.

  1. On the rotation period distribution of CoRoT and Kepler Sun-like stars

    CERN Document Server

    Leao, I C; Lopes, C E Ferreira; Neves, V; Valcarce, A A R; de Oliveira, L L A; da Silva, D Freire; de Freitas, D B; Martins, B L Canto; Janot-Pacheco, E; Baglin, A; De Medeiros, J R

    2015-01-01

    We study the distribution of the photometric rotation period (Prot), which is a direct measurement of the surface rotation at active latitudes, for three subsamples of Sun-like stars: one from CoRoT data and two from Kepler data. We identify the main populations of these samples and interpret their main biases particularly for a comparison with the solar Prot. Prot and variability amplitude (A) measurements were obtained from public CoRoT and Kepler catalogs, which were combined with public data of physical parameters. Because these samples are subject to selection effects, we computed synthetic samples with simulated biases to compare with observations, particularly around the Sun's HR-diagram location. Theoretical grids and empirical relations were used to combine physical parameters with Prot and A. Biases were simulated by performing cutoffs on the physical and rotational parameters in the same way as in each observed sample. A crucial cutoff is related with the detectability of the rotational modulation,...

  2. Simultaneous manipulation and observation of multiple ro-vibrational eigenstates in solid para-hydrogen

    Science.gov (United States)

    Katsuki, Hiroyuki; Ohmori, Kenji

    2016-09-01

    We have experimentally performed the coherent control of delocalized ro-vibrational wave packets (RVWs) of solid para-hydrogen (p-H2) by the wave packet interferometry (WPI) combined with coherent anti-Stokes Raman scattering (CARS). RVWs of solid p-H2 are delocalized in the crystal, and the wave function with wave vector k ˜ 0 is selectively excited via the stimulated Raman process. We have excited the RVW twice by a pair of femtosecond laser pulses with delay controlled by a stabilized Michelson interferometer. Using a broad-band laser pulse, multiple ro-vibrational states can be excited simultaneously. We have observed the time-dependent Ramsey fringe spectra as a function of the inter-pulse delay by a spectrally resolved CARS technique using a narrow-band probe pulse, resolving the different intermediate states. Due to the different fringe oscillation periods among those intermediate states, we can manipulate their amplitude ratio by tuning the inter-pulse delay on the sub-femtosecond time scale. The state-selective manipulation and detection of the CARS signal combined with the WPI is a general and efficient protocol for the control of the interference of multiple quantum states in various quantum systems.

  3. The fundamental parameters of the roAp star alpha Circini

    CERN Document Server

    Bruntt, H; Cunha, M; Brandao, I M; Elkin, V G; Kurtz, D W; Davis, J; Bedding, T R; Jacob, A P; Owens, S M; Robertson, J G; Tango, W J; Gameiro, J F; Ireland, M J; Tuthill, P G

    2008-01-01

    We have used the Sydney University Stellar Interferometer (SUSI) to measure the angular diameter of alpha Cir. This is the first detailed interferometric study of a rapidly oscillating A (roAp) star, alpha Cir being the brightest member of its class. We used the new and more accurate Hipparcos parallax to determine the radius to be 1.967+-0.066 Rs. We have constrained the bolometric flux from calibrated spectra to determine an effective temperature of 7420+-170 K. This is the first direct determination of the temperature of an roAp star. Our temperature is at the low end of previous estimates, which span over 1000 K and were based on either photometric indices or spectroscopic methods. In addition, we have analysed two high-quality spectra of alpha Cir, obtained at different rotational phases and we find evidence for the presence of spots. In both spectra we find nearly solar abundances of C, O, Si, Ca and Fe, high abundance of Cr and Mn, while Co, Y, Nd and Eu are overabundant by about 1 dex. The results rep...

  4. Observations of gas- and aerosol-phase organic nitrates at BEACHON-RoMBAS 2011

    Directory of Open Access Journals (Sweden)

    J. L. Fry

    2013-01-01

    Full Text Available At the Rocky Mountain Biogenic Aerosol Study (BEACHON-RoMBAS field campaign in the Colorado front range, July–August 2011, measurements of gas- and aerosol-phase organic nitrates enabled a study of the role of NOx (NOx = NO + NO2 in oxidation of forest-emitted VOCs and subsequent aerosol formation. Substantial formation of peroxy- and alkyl-nitrates is observed every morning, with an apparent 2.9% yield of alkyl nitrates from daytime RO2 + NO reactions. Aerosol-phase organic nitrates, however, peak in concentration during the night, with concentrations up to 140 ppt as measured by both optical spectroscopic and mass spectrometric instruments. The diurnal cycle in aerosol fraction of organic nitrates shows an equilibrium-like response to the diurnal temperature cycle, suggesting some reversible absorptive partitioning, but the full dynamic range cannot be reproduced by thermodynamic repartitioning alone. Nighttime aerosol organic nitrate is observed to be positively correlated with [NO2] × [O3] but not with [O3]. These observations support the role of nighttime NO3-initiated oxidation of monoterpenes as a significant source of nighttime aerosol. Nighttime production of organic nitrates exceeds daytime photochemical production at this site, which we postulate to be representative of the Colorado front range forests.

  5. Inventory of Onshore Hydrocarbon Seeps in Romania (HYSED-RO Database

    Directory of Open Access Journals (Sweden)

    Artur Ionescu

    2017-06-01

    Full Text Available Seeps are the expression of the migration of hydrocarbons from subsurface accumulations to the surface in sedimentary basins. They may represent an important indication of the presence of petroleum (gas and oil reservoirs and faults, and are a natural source of greenhouse gas (methane and atmospheric pollutants (ethane, propane to the atmosphere. Romania is one of the countries with the largest number of seeps in the world, due to the high petroleum potential and active tectonics. Based on a review of the available literature, and on the field surveys performed by the authors during the last 17 years, we report the first comprehensive GIS-based inventory of 470 seeps in Romania (HYSED-RO, including gas seeps (10.4% of the total, oil seeps (11.7%, mud volcanoes (50.4%, gas-rich springs (12.6%, asphalt (solid seeps (4.3%, unclassified manifestations (4.0%, and uncertain seeps (6.6%. Seeps are typically located in correspondence with major faults and vertical and fractured stratigraphic contacts associated to petroleum reservoirs (anticlines in low heat flow areas, and their gas-geochemistry reflects that of the subsurface reservoirs. The largest and most active seeps occur in the Carpathian Foredeep, where they release thermogenic gas, and subordinately in the Transylvanian Basin, where gas is mainly microbial. HYSED-RO may represent a key reference for baseline characterization prior to subsurface petroleum extraction, for environmental studies, and atmospheric greenhouse gas emission estimates in Romania.

  6. Constraints on the exosphere of CoRoT-7b

    CERN Document Server

    Guenther, E W; Erikson, A; Fridlund, M; Lammer, H; Mura, A; Rauer, H; Schneider, J; Tulej, M; von Paris, Ph; Wurz, P

    2010-01-01

    Context: The small radius and high density of CoRoT-7b implies that this transiting planet belongs to a different species than all transiting planets that have previously been found. Current models suggest that this is the first transiting rocky planet found outside the solar system. Given that the planet orbits a solar-like star at a distance of only 4.5 R*, it is expected that material from its surface is released which would then form an exosphere. AIMS: {Our aim is to constrain the properties of the exosphere by observing the planet in and out-of-transit. The detection of the exosphere of CoRoT-7b would for the first time allow to study the material originating from the surface of a rocky extrasolar planet. We survey the whole optical spectrum for any lines originating from the planet, particularly focusing on spectral-lines like those that have been detected in Mercury, and Io in our solar-system.} Methods: Given that it is expected that lines originating from the exosphere will be narrow, we observed Co...

  7. XX. CoRoT-20b: A very high density, high eccentricity transiting giant planet

    CERN Document Server

    Deleuil, M; Ferraz-Mello, S; Erikson, A; Bouchy, F; Havel, M; Aigrain, S; Almenara, J -M; Alonso, R; Auvergne, M; Baglin, A; Barge, P; Bordé, P; Bruntt, H; Cabrera, J; Carpano, S; Cavarroc, C; Csizmadia, Sz; Damiani, C; Deeg, H J; Dvorak, R; Fridlund, M; Hébrard, G; Gandolfi, D; Gillon, M; Guenther, E; Guillot, T; Hatzes, A; Jorda, L; Léger, A; Lammer, H; Mazeh, T; Moutou, C; Ollivier, M; Ofir, A; Parviainen, H; Queloz, D; Rauer, H; Rodríguez, A; Rouan, D; Santerne, A; Schneider, J; Tal-Or, L; Tingley, B; Weingrill, J; Wuchterl, G

    2011-01-01

    We report the discovery by the CoRoT space mission of a new giant planet, CoRoT-20b. The planet has a mass of 4.24 +/- 0.23 MJ and a radius of 0.84 +/- 0.04 RJ. With a mean density of 8.87 +/- 1.10 g/cm^3, it is among the most compact planets known so far. Evolution models for the planet suggest a mass of heavy elements of the order of 800 ME if embedded in a central core, requiring a revision either of the planet formation models or of planet evolution and structure models. We note however that smaller amounts of heavy elements are expected from more realistic models in which they are mixed throughout the envelope. The planet orbits a G-type star with an orbital period of 9.24 days and an eccentricity of 0.56. The star's projected rotational velocity is vsini = 4.5 +/- 1.0 km/s, corresponding to a spin period of 11.5 +/- 3.1 days if its axis of rotation is perpendicular to the orbital plane. In the framework of Darwinian theories and neglecting stellar magnetic breaking, we calculate the tidal evolution of t...

  8. Magnetic Doppler imaging of the roAp star HD 24712

    CERN Document Server

    Lüftinger, T; Ryabchikova, T; Piskunov, N; Weiss, W W; Ilyin, I

    2009-01-01

    We present the first magnetic Doppler images of a rapidly oscillating Ap (roAp) star. We deduce information about magnetic field geometry and abundance distributions of a number of chemical elements on the surface of the hitherto best studied roAp star, HD 24712, using the magnetic Doppler imaging (MDI) code, INVERS10, which allows us to reconstruct simultaneously and consistently the magnetic field geometry and elemental abundance distributions on a stellar surface. For this purpose we analyse time series spectra obtained in Stokes I and V parameters with the SOFIN polarimeter at the Nordic Optical Telescope and recover surface abundance structures of sixteen different chemical elements, respectively ions, including Mg, Ca, Sc, Ti, Cr, Fe, Co, Ni, Y, La, Ce, Pr, Nd, Gd, Tb, and Dy. For the rare earth elements (REE) Pr and Nd separate maps were obtained using lines of the first and the second ionization stage. We find and confirm a clear dipolar structure of the surface magnetic field and an unexpected correl...

  9. Ab initio ro-vibronic spectroscopy of SiCCl (X{sup ~2}Π)

    Energy Technology Data Exchange (ETDEWEB)

    Brites, Vincent [Université d’Evry Val d’Essonne, Laboratoire Analyse et Modélisation pour la Biologie et l’Environnement, LAMBE CNRS UMR 8587, Boulevard F. Mitterrand, 91025 Evry Cedex (France); Mitrushchenkov, Alexander O.; Léonard, Céline, E-mail: celine.leonard@u-pem.fr [Université Paris-Est, Laboratoire Modélisation et Simulation Multi Echelle, MSME UMR 8208 CNRS, 5 bd Descartes, 77454 Marne-la-Vallée (France); Peterson, Kirk A. [Department of Chemistry, Washington State University, Pullman, Washington 99164 (United States)

    2014-07-21

    The full dimensional potential energy surfaces of the {sup 2}A{sup ′} and {sup 2}A{sup ′′} electronic components of X{sup ~2}Π SiCCl have been computed using the explicitly correlated coupled cluster method, UCCSD(T)-F12b, combined with a composite approach taking into account basis set incompleteness, core-valence correlation, scalar relativity, and higher order excitations. The spin-orbit and dipole moment surfaces have also been computed ab initio. The ro-vibronic energy levels and absorption spectrum at 5 K have been determined from variational calculations. The influence of each correction on the fundamental frequencies is discussed. An assignment is proposed for bands observed in the LIF experiment of Smith et al. [J. Chem. Phys. 117, 6446 (2002)]. The overall agreement between the experimental and calculated ro-vibronic levels is better than 7 cm{sup −1} which is comparable with the 10–20 cm{sup −1} resolution of the emission spectrum.

  10. Marine bacterial transparent exopolymer particles (TEP) and TEP precursors: Characterization and RO fouling potential

    KAUST Repository

    Li, Sheng

    2015-10-31

    This paper investigated the characteristics and membrane fouling potential of bacterial transparent exopolymer particles (TEP)/TEP precursors released from two marine bacteria, Pseudidiomarina homiensis (P. homiensis) and Pseudoalteromonas atlantica (P. atlantica), isolated from the Red Sea. Results showed that both bacteria grew at the similar rate, but the production of TEP/TEP precursors from P. atlantica was higher than that from P. homiensis. During the 168. h of incubation time, production rates of TEP/TEP precursors from P. atlantica and P. homiensis were 0.30 and 0.08 xanthan gum eq. mg/L-h, respectively. Isolated bacterial TEP precursors were mainly biopolymer, and P. atlantica produced a significantly higher concentration of biopolymer than that produced by P. homiensis. TEP/TEP precursors from both marine bacteria possessed protein-like material and were very similar in composition to previously reported foulants isolated from a fouled reverse osmosis (RO) membrane. Bacterial TEP/TEP precursors mostly consisted of aliphatic hydrocarbon from amino acids and amide group carbon of proteins (around 55%). Bacterial TEP precursors caused obvious fouling on RO membranes, which may create an ideal environment for bacteria attachment and promote to biofouling.

  11. The design and application of ballast valve groups remote-control system for Ro-Ro ship%滚装船压载阀组遥控系统的设计与应用

    Institute of Scientific and Technical Information of China (English)

    万会雄; 明仁雄; 章琅浩

    2001-01-01

    了实现对滚装船压载舱压载阀的开闭实行有效的控 制,文章介绍了压载阀组遥控系统的组成、工作原理以及该系统的设计特点与应用。%To realize the effective control to starting an d shutting of ballast valve groups,this paper introduces the composition,working principle,designing features and application of ballast valve groups remote-co ntrol system for Ro-Ro ship.

  12. Transiting exoplanets from the CoRoT space mission. XII. CoRoT-12b: a short-period low-density planet transiting a solar analog star

    CERN Document Server

    Gillon, M; Csizmadia, Sz; Fridlund, M; Deleuil, M; Aigrain, S; Alonso, R; Auvergne, M; Baglin, A; Barge, P; Barnes, S I; Bonomo, A S; Bordé, P; Bouchy, F; Bruntt, H; Cabrera, J; Carone, L; Carpano, S; Cochran, W D; Deeg, H J; Dvorak, R; Endl, M; Erikson, A; Ferraz-Mello, S; Gandolfi, D; Gazzano, J C; Guenther, E; Guillot, T; Havel, M; Hébrard, G; Jorda, L; Léger, A; Llebaria, A; Lammer, H; Lovis, C; Mayor, M; Mazeh, T; Montalbán, J; Moutou, C; Ofir, A; Ollivier, M; Pätzold, M; Pepe, F; Queloz, D; Rauer, H; Rouan, D; Samuel, B; Santerne, A; Schneider, J; Tingley, B; Udry, S; Weingrill, J; Wuchterl, G

    2010-01-01

    We report the discovery by the CoRoT satellite of a new transiting giant planet in a 2.83 days orbit about a V=15.5 solar analog star (M_* = 1.08 +- 0.08 M_sun, R_* = 1.1 +- 0.1 R_sun, T_eff = 5675 +- 80 K). This new planet, CoRoT-12b, has a mass of 0.92 +- 0.07 M_Jup and a radius of 1.44 +- 0.13 R_Jup. Its low density can be explained by standard models for irradiated planets.

  13. Diazepam-induced release of behavior in an extinction procedure: its reversal by Ro 15-1788.

    Science.gov (United States)

    Thiébot, M H; Childs, M; Soubrié, P; Simon, P

    1983-03-18

    The effects of the benzodiazepine receptor antagonist Ro 15-1788, an imidazobenzodiazepine derivative, were studied with respect to three pharmacological activities exerted by diazepam in rats. Two of these, release of shock-induced suppression of drinking and attenuation of non-reward-induced cessation of responding for food, reflect the anxiolytic property of benzodiazepines. The amnesic-like effect of diazepam was also investigated. Ro 15-1788 (in doses ranging from 4 to 16 mg/kg p.o.) completely reversed diazepam (2 mg/kg)-induced release of behavior in both punishment and non-reward procedures. In contrast, Ro 15-1788 reduced but did not completely abolish diazepam-induced amnesia. These data suggest that the anticonflict and anti-frustration effects of benzodiazepines probably involve similar receptor types which nevertheless differ from those chiefly implicated in the amnesic-like activity of benzodiazepines.

  14. In vitro activity of Ro 23-9424, a dual-acting cephalosporin-quinolone antimicrobial agent.

    Science.gov (United States)

    Qadri, S M; Ueno, Y; Saldin, H; Cunha, B A

    1993-10-01

    In vitro activity of new dual-acting antibacterial Ro 23-9429 was tested against 1294 bacterial isolates from patients in a major tertiary care referral hospital in Saudi Arabia. Its activity was compared with that of ciprofloxacin, fleroxacin, ampicillin, cephalothin, cefoxitin, cefotaxime, ceftazidime, piperacillin, oxacillin, gentamicin, amikacin, imipenem, and vancomycin. Of the 621 members of Enterobacteriaceae tested, every single isolate was inhibited by Ro 23-9429 at minimum inhibitory concentration ranging between < .03 and 8 micrograms/mL. No other antimicrobial tested was as active as this dual-acting cephalosporin-fluoroquinolone. Similarly, all of the 255 isolates of Acinetobacter, Aeromonas hydrophila, Pseudomonas aeruginosa, and Xanthomonas maltophilia were susceptible to Ro 23-9429. It inhibited all the 120 isolates of methicillin-resistant Staphylococcus aureus. Its in vitro activity against coagulase-negative staphylococci and enterococci was superior or comparable to that of other drugs that are commonly used in clinical practice.

  15. A MAC Layer Based Defense Architecture for Reduction of Quality (RoQ) Attacks in Wireless LAN

    CERN Document Server

    Singh, Jatinder; Kaur, Lakhwinder

    2010-01-01

    Recently an alternative of DDoS attacks called shrew attacks or Reduction of Quality (RoQ) has been identified which is very much difficult to detect. The RoQ attacks can use source and destination IP address spoofing, and they do not have distinct periodicity, and may not filter the attack packets precisely. In this paper, we propose to design the MAC layer based defense architecture for RoQ attacks in Wireless LAN which includes the detection and response stages. The attackers are detected by checking the RTS CTS packets from the MAC layer and the corresponding attack flows are blocked or rejected. By our simulation results, we show that our proposed technique achieves reduces the attack throughput there by increasing the received bandwidth and reducing the packet loss of legitimate users.

  16. A Single-Chip Speech Dialogue Module and Its Evaluation on a Personal Robot, PaPeRo-Mini

    Science.gov (United States)

    Sato, Miki; Iwasawa, Toru; Sugiyama, Akihiko; Nishizawa, Toshihiro; Takano, Yosuke

    This paper presents a single-chip speech dialogue module and its evaluation on a personal robot. This module is implemented on an application processor that was developed primarily for mobile phones to provide a compact size, low power-consumption, and low cost. It performs speech recognition with preprocessing functions such as direction-of-arrival (DOA) estimation, noise cancellation, beamforming with an array of microphones, and echo cancellation. Text-to-speech (TTS) conversion is also equipped with. Evaluation results obtained on a new personal robot, PaPeRo-mini, which is a scale-down version of PaPeRo, demonstrate an 85% correct rate in DOA estimation, and as much as 54% and 30% higher speech recognition rates in noisy environments and during robot utterances, respectively. These results are shown to be comparable to those obtained by PaPeRo.

  17. BEER analysis of Kepler and CoRoT light curves. III. Spectroscopic confirmation of seventy new beaming binaries discovered in CoRoT lightcurves

    CERN Document Server

    Tal-Or, Lev; Mazeh, Tsevi

    2015-01-01

    (abridged for arXiv) The BEER algorithm, introduced by Faigler & Mazeh (2011), searches stellar lightcurves for the BEaming, Ellipsoidal, and Reflection photometric modulations caused by a short-period companion. Applying the search to the first five long-run center CoRoT fields, we identified $481$ non-eclipsing candidates with periodic flux amplitudes of $0.5-87$ mmag. Optimizing the Anglo-Australian-Telescope pointing coordinates and the AAOmega fiber-allocations with dedicated softwares, we acquired $6-7$ medium-resolution spectra of $281$ candidates in a seven-night campaign. Analysis of the red-arm AAOmega spectra, which covered the range of $8342-8842$ \\AA{}, yielded a radial-velocity precision of $\\sim1$ km/s. Spectra containing lines of more than one star were analyzed with TODCOR$-$the two-dimensional correlation algorithm. The measured radial velocities confirmed the binarity of seventy of the BEER candidates$-45$ single-line binaries, $18$ double-line binaries, and $7$ diluted binaries. We sho...

  18. Performance of advanced methods for treatment of wastewater: UV/TiO{sub 2}, RO and UF

    Energy Technology Data Exchange (ETDEWEB)

    Al-Bastaki, N.M. [Department of Chemical Engineering, College of Engineering, University of Bahrain (Bahrain)

    2004-07-01

    Photocatalytic and membrane processes are strong candidates for improving conventional water treatment processes. These advanced treatment methods are capable of removing many pollutant chemicals as well as pathogenic microorganisms. The objective of this work was to study the performance of small scale UV/TiO{sub 2} photocatalytic pilot plant process in treating secondary and tertiary treated effluent from a wastewater treatment plant in Bahrain. The performance was evaluated in terms of the efficiency of removing a chlorine resistant parasite, namely, Strongyloides Stercolaris, in addition to reducing the chemical oxygen demand (COD). The effect of pH and exposure time were considered. The performance of the UV/TiO{sub 2} was compared with small pilot scale ultrafiltration (UF) and reverse osmosis (RO) membrane processes. Treatment of the samples with each of the UV/TiO{sub 2}, UF and RO processes resulted in a complete removal of the Strongyloides Stercolaris parasites. Moreover, the chemical oxygen demand was reduced by about 50, 64 and 86% with each of UV/TiO{sub 2}, UF and RO. The specific power consumption of the UV/TiO{sub 2} process was estimated to be about 4.0 kWh/m{sup 3} for each of UV/TiO{sub 2} and sea water RO (SWRO) and 1.0 kWh/m{sup 3} and 0.9 kWh/m{sup 3} for each of brakish water RO (BWRO) and cross flow UF, respectively. The UV/TiO{sub 2} process produces no waste stream, whereas the RO and UF processes generate waste streams which are concentrated in the microorganisms and suspended organic matter, which result in a disposal problem. (author)

  19. Efficiently Combining Water Reuse and Desalination through Forward Osmosis—Reverse Osmosis (FO-RO) Hybrids: A Critical Review

    Science.gov (United States)

    Blandin, Gaetan; Verliefde, Arne R.D.; Comas, Joaquim; Rodriguez-Roda, Ignasi; Le-Clech, Pierre

    2016-01-01

    Forward osmosis (FO) is a promising membrane technology to combine seawater desalination and water reuse. More specifically, in a FO-reverse osmosis (RO) hybrid process, high quality water recovered from the wastewater stream is used to dilute seawater before RO treatment. As such, lower desalination energy needs and/or water augmentation can be obtained while delivering safe water for direct potable reuse thanks to the double dense membrane barrier protection. Typically, FO-RO hybrid can be a credible alternative to new desalination facilities or to implementation of stand-alone water reuse schemes. However, apart from the societal (public perception of water reuse for potable application) and water management challenges (proximity of wastewater and desalination plants), FO-RO hybrid has to overcome technical limitation such as low FO permeation flux to become economically attractive. Recent developments (i.e., improved FO membranes, use of pressure assisted osmosis, PAO) demonstrated significant improvement in water flux. However, flux improvement is associated with drawbacks, such as increased fouling behaviour, lower rejection of trace organic compounds (TrOCs) in PAO operation, and limitation in FO membrane mechanical resistance, which need to be better considered. To support successful implementation of FO-RO hybrid in the industry, further work is required regarding up-scaling to apprehend full-scale challenges in term of mass transfer limitation, pressure drop, fouling and cleaning strategies on a module scale. In addition, refined economics assessment is expected to integrate fouling and other maintenance costs/savings of the FO/PAO-RO hybrid systems, as well as cost savings from any treatment step avoided in the water recycling. PMID:27376337

  20. Efficiently Combining Water Reuse and Desalination through Forward Osmosis—Reverse Osmosis (FO-RO Hybrids: A Critical Review

    Directory of Open Access Journals (Sweden)

    Gaetan Blandin

    2016-07-01

    Full Text Available Forward osmosis (FO is a promising membrane technology to combine seawater desalination and water reuse. More specifically, in a FO-reverse osmosis (RO hybrid process, high quality water recovered from the wastewater stream is used to dilute seawater before RO treatment. As such, lower desalination energy needs and/or water augmentation can be obtained while delivering safe water for direct potable reuse thanks to the double dense membrane barrier protection. Typically, FO-RO hybrid can be a credible alternative to new desalination facilities or to implementation of stand-alone water reuse schemes. However, apart from the societal (public perception of water reuse for potable application and water management challenges (proximity of wastewater and desalination plants, FO-RO hybrid has to overcome technical limitation such as low FO permeation flux to become economically attractive. Recent developments (i.e., improved FO membranes, use of pressure assisted osmosis, PAO demonstrated significant improvement in water flux. However, flux improvement is associated with drawbacks, such as increased fouling behaviour, lower rejection of trace organic compounds (TrOCs in PAO operation, and limitation in FO membrane mechanical resistance, which need to be better considered. To support successful implementation of FO-RO hybrid in the industry, further work is required regarding up-scaling to apprehend full-scale challenges in term of mass transfer limitation, pressure drop, fouling and cleaning strategies on a module scale. In addition, refined economics assessment is expected to integrate fouling and other maintenance costs/savings of the FO/PAO-RO hybrid systems, as well as cost savings from any treatment step avoided in the water recycling.

  1. Efficiently Combining Water Reuse and Desalination through Forward Osmosis-Reverse Osmosis (FO-RO) Hybrids: A Critical Review.

    Science.gov (United States)

    Blandin, Gaetan; Verliefde, Arne R D; Comas, Joaquim; Rodriguez-Roda, Ignasi; Le-Clech, Pierre

    2016-07-01

    Forward osmosis (FO) is a promising membrane technology to combine seawater desalination and water reuse. More specifically, in a FO-reverse osmosis (RO) hybrid process, high quality water recovered from the wastewater stream is used to dilute seawater before RO treatment. As such, lower desalination energy needs and/or water augmentation can be obtained while delivering safe water for direct potable reuse thanks to the double dense membrane barrier protection. Typically, FO-RO hybrid can be a credible alternative to new desalination facilities or to implementation of stand-alone water reuse schemes. However, apart from the societal (public perception of water reuse for potable application) and water management challenges (proximity of wastewater and desalination plants), FO-RO hybrid has to overcome technical limitation such as low FO permeation flux to become economically attractive. Recent developments (i.e., improved FO membranes, use of pressure assisted osmosis, PAO) demonstrated significant improvement in water flux. However, flux improvement is associated with drawbacks, such as increased fouling behaviour, lower rejection of trace organic compounds (TrOCs) in PAO operation, and limitation in FO membrane mechanical resistance, which need to be better considered. To support successful implementation of FO-RO hybrid in the industry, further work is required regarding up-scaling to apprehend full-scale challenges in term of mass transfer limitation, pressure drop, fouling and cleaning strategies on a module scale. In addition, refined economics assessment is expected to integrate fouling and other maintenance costs/savings of the FO/PAO-RO hybrid systems, as well as cost savings from any treatment step avoided in the water recycling.

  2. The use of HeRo catheter in catheter-dependent dialysis patients with superior vena cava occlusion.

    Science.gov (United States)

    Davis, Kathryn L; Gurley, John C; Davenport, Daniel L; Xenos, Eleftherios S

    2016-01-01

    Hemodialysis (HD) patients with superior vena cava (SVC) occlusion have limited access options. Femoral access is commonly employed but is associated with high complication rates. Hemodialysis Reliable Outflow (HeRO) catheters can be used in tunneled catheter-dependent (TCD) patients who have exhausted other access options. The HeRO graft bypasses occlusion and traverses stenosis with outflow directly into the central venous circulation. At our institution we have used the inside-out central venous access technique (IOCVA) to traverse an occluded vena cava for HeRO graft placement. We review our experience with this technique. A retrospective chart review was conducted of patients with HeRO graft placement at our institution. All were dependent on a tunneled femoral dialysis catheter due to central venous occlusion (CVO). The IOCVA technique was used in each case. This technique was used as last resort for patients who had no other dialysis access option. Demographics, patency rates, complications, and mortality were recorded. A total of 11 HeRO grafts were placed in 11 patients from January 2012 to June 2013, with 100% technical success rate. Three grafts were ligated due to steal syndrome. Two grafts were lost due to thrombosis. Five of 11 patients experienced a 30-day complication. Three patients died within the follow-up period; however, none were directly related to the graft placement. Follow up range was 65-573 days; 5 of 11 grafts were used for dialysis at the end of the follow-up period. The 12-month patency rate was 30%. HeRO grafts are one option for dialysis patients with CVO. There is, however, a high incidence of steal syndrome and other complications. These grafts should be offered as a final potential alternative to catheter dependence.

  3. Disputas a orillas del r??o Uruguay. Guerra y paz con los minuanes en el siglo XVIII

    OpenAIRE

    Svriz Wucherer, Pedro Miguel Omar

    2011-01-01

    Diversas circunstancias llevaron a firmar un tratado de paz entre los indios minuanes y los espa??oles residentes en Buenos Aires hacia 1732. Abordaremos este proceso desde una perspectiva amplia, buscando alcanzar una comprensi??n mayor de los sucesos y sus protagonistas. Los indios que habitaban las tierras situadas entre el oriente del r??o Paran?? y el sur del r??o Ibicuy, asediaban con continuas correr??as y saqueos las ciudades de Corrientes, Santa Fe y Buenos Aires. Fundamentalmente pe...

  4. The flotation of Roşia Poieni copper ore in column machine, with non-polar oils addition

    Directory of Open Access Journals (Sweden)

    Ciocani V.

    2005-11-01

    Full Text Available The most important natural resource of copper in Romania is the ore deposit of Roşia Poieni. At present, the utilization of Roşia Poieni poorphyry copper ore is possible by extraction in quarry of the mass ore and mineral processing into a technological flux with modest results for the value of metal recovery in concentrate 70-72 % and an average contents of 16,5 % Cu. Our researches were directed to studies regarding test and utilisation of special procedure of flotation – addition of the non-polar oil – applied to advanced grinding ore with column type machines.

  5. How to separate the low amplitude delta Scuti variation from the instrumental ones in CoRoT data?

    CERN Document Server

    Benkő, J M

    2016-01-01

    Rich regular frequency patterns were found in the Fourier spectra of low-amplitude delta Scuti stars observed by CoRoT satellite (see Papar\\'o et al. 2016a,b). The CoRoT observations are, however, influenced by the disturbing effect of the South Atlantic Anomaly. The effect is marginal for high amplitude variable stars but it could be critical in the case of low amplitude variables, especially if the frequency range of the intrinsic variation overlaps the interval of the instrumental frequencies. Some tests were carried out both on synthetic and real data for distinguishing technical and stars' frequencies.

  6. The gamma Dor CoRoT target HD49434. I-Results from the ground-based campaign

    OpenAIRE

    Uytterhoeven, K.; Mathias, P.; Poretti, E.; RAINER, M.; Martin-Ruiz, S.; Rodriguez, E.; Amado, P. J.; LeContel, D.; Jankov, S.; Niemczura, E.; Pollard, K.; Brunsden, E.; M. Paparo; Costa, V; Valtier, J.-C.

    2008-01-01

    Context: We present the results of an extensive ground-based photometric and spectroscopic campaign on the gamma Dor CoRoT target HD49434. This campaign was preparatory to the CoRoT satellite observations, which took place from October 2007 to March 2008. Results: The frequency analysis clearly shows the presence of four frequencies in the 0.2-1.7 c/d interval, as well as six frequencies in the 5-12 c/d domain. The low frequencies are typical for gamma Dor variables while the high frequencies...

  7. Measurements of tropospheric HO2 and RO2 by oxygen dilution modulation and chemical ionization mass spectrometry

    Directory of Open Access Journals (Sweden)

    J. S. Olson

    2011-01-01

    Full Text Available An improved method for the measurement of hydroperoxy radicals (HO2 and organic peroxy radicals (RO2, where R is any organic group has been developed that combines two previous chemical conversion/chemical ionization mass spectrometry (CIMS peroxy radical measurement techniques. Applicable to both ground-based and aircraft platforms, the method provides good separation between HO2 and RO2 and frequent measurement capability with observations of both HO2 and HO2+RO2 amounts each minute. This allows for analyses of measured [HO2]/[HO2+RO2] ratios on timescales relevant to tropospheric photochemistry. By varying both [NO] and [O2] simultaneously in the chemical conversion region of the PeRCIMS (Peroxy Radical CIMS inlet, the method exploits the changing conversion efficiency of RO2 to HO2 under different inlet [NO]/[O2] to selectively observe either primarily HO2 or the sum of HO2 and RO2. Two modes of operation have been established for ambient measurements: in the first half of the minute, RO2 radicals are measured at close to 100% efficiency along with HO2 radicals (low [NO]/[O2] = 2.53×10−5 and in the second half of the minute, HO2 is detected while the majority of ambient RO2 radicals are measured with low efficiency, approximately 15% (high [NO]/[O2] = 6.80×10−4. The method has been tested extensively in the laboratory under various conditions and for a variety of organic peroxy radicals relevant to the atmosphere and the results of these tests are presented. The modified PeRCIMS instrument has been deployed successfully using the new measurement technique on a number of aircraft campaigns, including on the NSF/NCAR C-130 during the MIRAGE-Mex and NASA INTEX-B field campaigns in the spring of 2006. A brief comparison of the peroxy radical measurements during these campaigns to a photochemical box model indicates good agreement under tropospheric conditions where NOx (NO+NO2 concentrations are lower than 0.5 ppbV (parts per billion by

  8. Measurements of tropospheric HO2 and RO2 by oxygen dilution modulation and chemical ionization mass spectrometry

    Directory of Open Access Journals (Sweden)

    J. S. Olson

    2011-04-01

    Full Text Available An improved method for the measurement of hydroperoxy radicals (HO2 and organic peroxy radicals (RO2, where R is any organic group has been developed that combines two previous chemical conversion/chemical ionization mass spectrometry (CIMS peroxy radical measurement techniques. Applicable to both ground-based and aircraft platforms, the method provides good separation between HO2 and RO2, and frequent measurement capability with observations of both HO2 and HO2 + RO2 amounts each minute. These improvements allow for analyses of measured [HO2]/[HO2 + RO2] ratios on timescales relevant to tropospheric photochemistry. By varying both [NO] and [O2] simultaneously in the chemical conversion region of the PeRCIMS (Peroxy Radical CIMS inlet, the method exploits the changing conversion efficiency of RO2 to HO2 under different inlet [NO]/[O2] to selectively observe either primarily HO2 or the sum of HO2 and RO2. Two modes of operation have been established for ambient measurements: in the first half of the minute, RO2 radicals are measured at close to 100% efficiency along with HO2 radicals (low [NO]/[O2] = 2.53 × 10−5 and in the second half of the minute, HO2 is detected while the majority of ambient RO2 radicals are measured with low efficiency, approximately 15% (high [NO]/[O2] = 6.80 × 10−4. The method has been tested extensively in the laboratory under various conditions and for a variety of organic peroxy radicals relevant to the atmosphere and the results of these tests are presented. The modified PeRCIMS instrument has been deployed successfully using the new measurement technique on a number of aircraft campaigns, including on the NSF/NCAR C-130 during the MIRAGE-Mex and NASA INTEX-B field campaigns in the spring of 2006. A brief comparison of the peroxy radical measurements during these campaigns to a photochemical box model indicates good agreement under tropospheric conditions where NOx (NO + NO2 concentrations are lower than 0.5 ppb

  9. Cost analysis of the Hemodialysis Reliable Outflow (HeRO) Graft compared to the tunneled dialysis catheter.

    Science.gov (United States)

    Al Shakarchi, Julien; Inston, Nicholas; Jones, Robert G; Maclaine, Grant; Hollinworth, David

    2016-04-01

    In end-stage renal disease patients with central venous obstruction, who have limited vascular access options, the Hemodialysis Reliable Outflow (HeRO) Graft is a new alternative with a lower incidence of complications and longer effective device life compared to tunneled dialysis catheters (TDCs). We undertook an economic analysis of introducing the HeRO Graft in the UK. A 1-year cost-consequence decision analytic model was developed comparing management with the HeRO Graft to TDCs from the perspective of the National Health Service in England. The model comprises four 3-month cycles during which the vascular access option either remains functional for hemodialysis or fails, patients can experience access-related infection and device thrombosis, and they can also accrue associated costs. Clinical input data were sourced from published studies and unit cost data from National Health Service 2014-15 Reference Costs. In the base case, a 100-patient cohort managed with the HeRO Graft experienced 6 fewer failed devices, 53 fewer access-related infections, and 67 fewer device thromboses compared to patients managed with TDCs. Although the initial device and placement costs for the HeRO Graft are greater than those for TDCs, savings from the lower incidence of device complications and longer effective device patency reduces these costs. Overall net annual costs are £2600 for each HeRO Graft-managed patient compared to TDC-managed patients. If the National Health Service were to reimburse hemodialysis at a uniform rate regardless of the type of vascular access, net 1-year savings of £1200 per patient are estimated for individuals managed with the HeRO Graft. The base case results showed a marginal net positive cost associated with vascular access with the HeRO Graft compared with TDCs for the incremental clinical benefit of reductions in patency failures, device-related thrombosis, and access-related infection events in a patient population with limited options for

  10. Observations of roAp stars at the Mt.Dushak-Erekdag station of Odessa Astronomical Observatory

    CERN Document Server

    Dorokhova, T N

    1998-01-01

    Since 1992, observations of roAp stars have been carried out using the dual-channel photometer attached to the 0.8m telescope, which is situated in Central Asia, at the Mt. Dushak-Erekdag station of Odessa Astronomical Observatory. Some results of observations of gamma Equ and of HD 134214 are presented. 5 stars were investigated as roAp candidates. The Fourier spectra of 4 stars did not show any variability in the high-frequency region. The Fourier spectrum of HD 99563 revealed a peak at a frequency f=128.9 c/d and with a semi-amplitude of 3.98 mmag.

  11. Summertime photochemistry during CAREBeijing-2007: RO x budgets and O3 formation

    Directory of Open Access Journals (Sweden)

    A. Amoroso

    2012-02-01

    Full Text Available We analyze summertime photochemistry near the surface over Beijing, China, using a 1-D photochemical model (Regional chEmical and trAnsport Model, REAM-1D constrained by in situ observations, focusing on the budgets of ROx (OH + HO2 + RO2 radicals and O3 formation. The daytime average of total ROx primary production rate in Beijing is ~6.6 ppbv h−1, among the highest found in urban atmospheres. The largest primary ROx source in Beijing is photolysis of oxygenated volatile organic compounds (OVOCs, which produces HO2 and RO2 at average daytime rates of 2.5 ppbv h−1 and 1.7 ppbv h−1, respectively. Photolysis of excess HONO from the unknown heterogeneous source is a predominant primary OH source at 2.2 ppbv h−1, much larger than that of O1D + H2O (0.4 ppbv h−1. The largest ROx sink is via OH + NO2 reaction (1.6 ppbv h−1, followed by formation of RO2NO2 (1.0 ppbv h−1 and RONO2 (0.7 ppbv h−1. Due to the large aerosol surface area, aerosol uptake of HO2 appears to be another important radical sink, although the estimate of its magnitude is highly variable depending on the reactive uptake coefficient value used. The daytime average O3 production and loss rates are 32 ppbv h−1 and 6.2 ppbv h−1, respectively. Assuming NO2 to be the source of excess HONO, the NO2 to HONO transformation leads to significant O3 loss and reduction of its lifetime. Our observation-based modeling analyses suggest that VOCs and heterogeneous reactions (e.g. HONO formation and aerosol uptake HO2 play major roles in the primary radical budget and O3 formation in Beijing. Among the VOC precursors for OVOCs, which strongly affect ROx budgets and O3 formation, aromatics are the largest contributor. One important ramification is that O3 production is neither NOx nor VOC limited, but in a transition regime, where reduction of either NOx or VOCs could result in reduction of O3 production. The transition regime implies more flexibility in the O3 control strategies

  12. Analysis and Countermeasures of Organization of Drop and Pull Transportation in Ro-Ro Transportation%滚装运输中的甩挂运输组织分析及对策

    Institute of Scientific and Technical Information of China (English)

    靳志宏; 韩雪梅; 靳新; 杨光敏

    2013-01-01

    In this paper, we analyzed quantitatively the advantage and disadvantage of the drop and pull transportation mode and conventional transportation modes in the Ro-Ro transportation market, applied the fuzzy AHP in a quantitative evaluation of the two organizational arrangements, and then proposed accordingly the implementation of drop and pull transportation in Ro-Ro transportation.%在定性分析滚装运输市场传统组织方式与甩挂组织方式优劣势的基础上,应用模糊层次分析法对滚装运输两种组织方式进行定量评价,结果表明甩挂组织方式对滚装运输整体效益贡献较大,进而对滚装运输甩挂运输组织的实施提出了对策。

  13. 鲁辽滚装船甩挂运输的业务流程设计%Design of Business Process of Ro-ro Drop & Pull Transportation in Shandong-Liaoning Region

    Institute of Scientific and Technical Information of China (English)

    吕延昌

    2014-01-01

    In this paper, on the basis of the basic theory concerning the ro-ro drop & pull transportation, and the practice of this transportation mode both in China and abroad, we discussed the characteristics and prerequisite for its implementation in the Shandong-Liaoning region, presented the operational process for different vehicles under this mode, and at the end presented the ro-ro container shipping process of low-chassis trucks used specially at terminals.%在阐述滚装船甩挂运输的基本理论和国内外滚装运输的基础上,针对鲁辽滚装船开展甩挂运输的特点,论述了开展滚装船甩挂运输的前提条件。分析了厢式、敞式、仓栅式、平板半挂车和罐式半挂车的滚装船甩挂运输流程,提出了采用专用码头低底盘车装载集装箱进行滚装船运输的流程。

  14. Transiting exoplanets from the CoRoT space missionXIX. CoRoT-19b: A low density planet orbiting an old inactive F9V-star

    CERN Document Server

    Guenther, E W; Gazzano, J -C; Mazeh, T; Rouan, D; Gibson, N; Csizmadia, Sz; Aigrain, S; Alonso, R; Almenara, J M; Auvergne, M; Baglin, A; Barge, P; Bonomo, A S; Borde, P; Bouchy, F; Bruntt, H; Cabrera, J; Carone, L; Carpano, S; Cavarroc, C; Deeg, H J; Deleuil, M; Dreizler, S; Dvorak, R; Erikson, A; Ferraz-Mello, S; Fridlund, M; Gandolfi, D; Gillon, M; Guillot, T; Hatzes, A; Havel, M; Hebrard, G; Jehin, E; Jorda, L; Lammer, H; Leger, A; Moutou, C; Nortmann, L; Ollivier, M; Ofir, A; Pasternacki, Th; Paetzold, M; Parviainen, H; Queloz, D; Rauer, H; Samuel, B; Santerne, A; Schneider, J; Tal-Or, L; Tingley, B; Weingrill, J; Wuchterl, G

    2011-01-01

    Observations of transiting extrasolar planets are of key importance to our understanding of planets because their mass, radius, and mass density can be determined. The CoRoT space mission allows us to achieve a very high photometric accuracy. By combining CoRoT data with high-precision radial velocity measurements, we derive precise planetary radii and masses. We report the discovery of CoRoT-19b, a gas-giant planet transiting an old, inactive F9V-type star with a period of four days. After excluding alternative physical configurations mimicking a planetary transit signal, we determine the radius and mass of the planet by combining CoRoT photometry with high-resolution spectroscopy obtained with the echelle spectrographs SOPHIE, HARPS, FIES, and SANDIFORD. To improve the precision of its ephemeris and the epoch, we observed additional transits with the TRAPPIST and Euler telescopes. Using HARPS spectra obtained during the transit, we then determine the projected angle between the spin of the star and the orbi...

  15. Diagnostic and prognostic significance of measuring antibodies to alpha-fodrin compared to anti-Ro-52, anti-Ro-60, and anti-La in primary Sjogren's syndrome

    DEFF Research Database (Denmark)

    Pelck, R.; Manthorpe, R.; Locht, Henning

    2008-01-01

    OBJECTIVE: To compare sensitivity and specificity of autoantibodies to alpha-fodrin with conventional anti-Ro and anti-La antibodies in patients with primary Sjogren's syndrome (pSS). Data on internal organ manifestations were correlated with presence of autoantibodies. METHODS: We collected...

  16. Transiting exoplanets from the CoRoT space mission IV: CoRoT-Exo-4b: A transiting planet in a 9.2 day synchronous orbit

    CERN Document Server

    Aigrain, S; Ollivier, M; Pont, F; Jorda, L; Almenara, J M; Alonso, R; Barge, P; Borde, P; Bouchy, F; Deeg, H; De la Reza, R; Deleuil, M; Dvorak, R; Erikson, A; Fridlund, M; Gondoin, P; Gillon, M; Guillot, T; Hatzes, A; Lammer, H; Lanza, A F; Léger, A; Llebaria, A; Magain, P; Mazeh, T; Moutou, C; Paetzold, M; Pinte, C; Queloz, D; Rauer, H; Rouan, D; Schneider, J; Wuchter, G; Zucker, S

    2008-01-01

    CoRoT, the first space-based transit search, provides ultra-high precision light curves with continuous time-sampling over periods, of up to 5 months. This allows the detection of transiting planets with relatively long periods, and the simultaneous study of the host star's photometric variability. In this letter, we report on the discovery of the transiting giant planet CoRoT-Exo-4b and use the CoRoT light curve to perform a detailed analysis of the transit and to determine the stellar rotation period. The CoRoT light curve was pre-processed to remove outliers and correct for orbital residuals and artefacts due to hot pixels on the detector. After removing stellar variability around each transit, the transit light curve was analysed to determine the transit parameters. A discrete auto-correlation function method was used to derive the rotation period of the star from the out-of-transit light curve. We derive periods for the planet's orbit and star's rotation of 9.20205 +/- 0.00037 and 8.87 +/- 1.12 days resp...

  17. DESTRUCTION OF ANTI-SCALANTS IN RO CONCENTRATES BY ELECTROCHEMICAL OXIDATION%反渗透浓缩液中阻垢剂的电化学破坏

    Institute of Scientific and Technical Information of China (English)

    杨庆峰; 马紫峰; HASSON David; SEMIAT Raphael

    2004-01-01

    Scaling on heat transfer surface and reverse osmosis(RO) membrane surface[35 is one of thc main problems in desalination processes. To mitigate scales, anti-scalants are often used. For RO system, membrane concentrates contain high amounts of dissolved salts and anti-sealants. Concentratcs are discharged directly. In fact, concentrates are high quality water

  18. La fin du risque zéro : du homegrown jihadism au terrorisme du loup solitaire

    Directory of Open Access Journals (Sweden)

    Rémi Baudouï

    2015-09-01

    Full Text Available Le risque zéro représente un moment historique particulier dans la conceptualisation de la socio-politique du risque. Son application repose au début des années 1980 sur l’hypothèse de la possibilité de progresser dans le domaine de l’anticipation et de la gestion sécuritaire des crises potentielles au point de pouvoir prémunir les populations contre toute forme de menace. Il fut employé dans les domaines de la protection civile et de la sécurité militaire. Comme élément de gouvernance politique, il réfutait l’idée selon laquelle le risque existe en préalable comme catégorie d’acceptabilité collective de la menace.

  19. The religiosity and the quotidian in the city of Alto Paraíso (RO)

    OpenAIRE

    2003-01-01

    O objetivo da presente pesquisa é explicitar a relação entre a religião e a vida cotidiana na cid ade de Alto Paraíso (RO). Pretende discutir o papel do imaginário religioso no processo de ocupação de um novo espaço geográfico e na luta pela sobrevivência neste contexto. Sistematiza, assim, a história de uma cidade a partir de depoimentos de seus primeiros habitantes, perguntando pelo lugar da religião nesta memória. A metodologia privilegia o depoimento oral, colhido através da técn...

  20. Physical State of the Deep Interior of the CoRoT-7b Exoplanet

    CERN Document Server

    Wagner, F W; Rückriemen, T; Rauer, H

    2011-01-01

    The present study takes the CoRoT-7b exoplanet as an analogue for massive terrestrial planets to investigate conditions, under which intrinsic magnetic fields could be sustained in liquid cores. We examine the effect of depth-dependent transport parameters (e.g., activation volume of mantle rock) on a planet's thermal structure and the related heat flux across the core mantle boundary. For terrestrial planets more massive than the Earth, our calculations suggest that a substantial part of the lowermost mantle is in a sluggish convective regime, primarily due to pressure effects on viscosity. Hence, we find substantially higher core temperatures than previously reported from parameterized convection models. We also discuss the effect of melting point depression in the presence of impurities (e.g., sulfur) in iron-rich cores and compare corresponding melting relations to the calculated thermal structure. Since impurity effects become less important at the elevated pressure and temperature conditions prevalent i...

  1. RoHS directive: restriction of the use of lead in electronic equipment

    CERN Multimedia

    2007-01-01

    The European Restriction of Hazardous Substances (RoHS) directive, which entered into force on 1st July 2006, restricts the use of lead in the manufacture of electronic equipment. This has many consequences for the manufacture of printed circuit boards and assemblies, from their design and repair to the purchase of components. If you have any questions on this subject, we invite you to attend a training session which will be held at CERN from 1.30 to 5.30 p.m. on 21st June. All the details, including the course contents and instructions on how to register for it, can be found here. Please note that the session will be held in French.

  2. RoHS directive: restriction of the use of lead in electronic equipment

    CERN Multimedia

    2007-01-01

    The European Restriction of Hazardous Substances (RoHS) directive, which entered into force on 1st July 2006, restricts the use of lead in the manufacture of electronic equipment. This has many consequences for the manufacture of printed circuit boards and assemblies, from their design and repair to the purchase of components. If you have any questions on this subject, we invite you to attend a training session which will be held at CERN from 1.30 to 5.30 to p.m. on 21st June. All the details, including the course contents and instructions on how to register for it, can be found here Please note that the session will be held in French.

  3. Ro-vibrational averaging of the isotropic hyperfine coupling constant for the methyl radical

    Energy Technology Data Exchange (ETDEWEB)

    Adam, Ahmad Y.; Jensen, Per, E-mail: jensen@uni-wuppertal.de [Fakultät Mathematik und Naturwissenschaften, Physikalische und Theoretische Chemie, Bergische Universität Wuppertal, D-42097 Wuppertal (Germany); Yachmenev, Andrey; Yurchenko, Sergei N. [Department of Physics and Astronomy, University College London, Gower Street, London WC1E 6BT (United Kingdom)

    2015-12-28

    We present the first variational calculation of the isotropic hyperfine coupling constant of the carbon-13 atom in the CH{sub 3} radical for temperatures T = 0, 96, and 300 K. It is based on a newly calculated high level ab initio potential energy surface and hyperfine coupling constant surface of CH{sub 3} in the ground electronic state. The ro-vibrational energy levels, expectation values for the coupling constant, and its temperature dependence were calculated variationally by using the methods implemented in the computer program TROVE. Vibrational energies and vibrational and temperature effects for coupling constant are found to be in very good agreement with the available experimental data. We found, in agreement with previous studies, that the vibrational effects constitute about 44% of the constant’s equilibrium value, originating mainly from the large amplitude out-of-plane bending motion and that the temperature effects play a minor role.

  4. High-efficiency optical coupling single-sideband modulation for OFDM-RoF-PON systems

    Science.gov (United States)

    Xue, Xuwei; Ji, Wei; Kang, Zhaoyuan; Huang, Kangrui; Li, Xiao

    2015-12-01

    We report on an OFDM-RoF-PON system based on novel optical coupling single-sideband (O-SSB) modulation for one wavelength carrying one baseband and two radio frequency (RF) signals. The impact of nonlinear distortion consisting of harmonic distortion (HD) and intermodulation distortion (IMD) in this system is theoretically investigated. Transmission over 0 km and 40 km of standard single mode fiber is successfully demonstrated and it is indicated that modulation index 0.6 is more adapted to O-SSB modulation. The error vector magnitude (EVM) of system based on O-SSB modulation after transmission over 40 km is <0.1. For O-SSB modulation, bit error rate (BER) after 40 km transmission is below forward error correction (FEC) limit of 10-3.

  5. An Automated Planning Model for RoF Heterogeneous Wireless Networks

    DEFF Research Database (Denmark)

    Shawky, Ahmed; Bergheim, Hans; Ragnarsson, Ólafur;

    2010-01-01

    The number of users in wireless WANs is increasing like never before, at the same time as the bandwidth demands by users increase.The structure of the third generation Wireless WANs makes it expensive for Wireless ISPs to meet these demands.The FUTON architecture is a RoF heterogeneous wireless...... network architecture under development,that will be cheaper to deploy and operate.This paper shows a method to plan an implementation of this architecture.The planning is done as automatic as possible,covering radio planning, fiber planning and network dimensioning. The out come of the paper is a planning...... process that uses GIS-data to automate planning for the entire architecture.The automated model uses a collection of scripts that can easily be modified for planning a FUTON architecture anywhere. The scripts are made using functions for the different tasks, inorder to make them easy to extend and modify....

  6. Study on the License Requirements for the SRO/RO of the Kijang Research Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Subeom; Shin, Taemyung [Korea Nat. University of Transportation, Seoul (Korea, Republic of); Chae, H. T.; Ahn, G. H. [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); Kim, S. J.; Gam, S. C. [Korea Institute of Nuclear Safety, Daejeon (Korea, Republic of)

    2016-10-15

    The purpose of the study is to propose an appropriate regulatory position for the Kijang reactor operator license requirement by the review of the applicability and compatibility of HANARO SRO/RO license holders for Kijang reactor operation. As the area using radioactive isotope became gradually enlarged both inside and outside of the country, the Kijang research reactor is planned and now under construction next to the HANARO research reactor now being operated in Taejon. In this paper, therefore, an establishment of revised operator license system is discussed for the new research reactor. The design and operation characteristics of the two (HANARO and Kijang) reactors are concluded to be very similar to each other, however, there still exist slight differences in some minor portions. It is recommendable to allow an independent license for each reactor if two reactors of the same power level have recognizable differences in the design and operation characteristics.

  7. A class of singular Ro-matrices and extensions to semidefinite linear complementarity problems

    Directory of Open Access Journals (Sweden)

    Sivakumar K.C.

    2013-01-01

    Full Text Available For ARnxn and qRn, the linear complementarity problem LCP(A, q is to determine if there is xRn such that x ≥ 0; y = Ax + q ≥ 0 and xT y = 0. Such an x is called a solution of LCP(A,q. A is called an Ro-matrix if LCP(A,0 has zero as the only solution. In this article, the class of R0-matrices is extended to include typically singular matrices, by requiring in addition that the solution x above belongs to a subspace of Rn. This idea is then extended to semidefinite linear complementarity problems, where a characterization is presented for the multplicative transformation.

  8. Effectiveness of Subsidies in Technology Adoption: A Case Study Involving Reverse Osmosis (RO Membrane Technology

    Directory of Open Access Journals (Sweden)

    Nur Laili

    2016-12-01

    Full Text Available Adoption of new technologies is a process that involves technological learning and penetration of new products into the market. Within the process of new technologies adoption, government usually intervened by providing incentives, in order to support the technology adoption to be succeed. This paper examines the effectiveness of incentives for the sustainability of reverse osmosis (RO membrane technology adoption. The study conducted through single case study on SWRO installation in Mandangin Island, East Java, Indonesia. Results of case study indentify the existence of government incentive in the form of direct subsidies to decrease the price of clean water. Although successful in reducing the price of water, but effectiveness of the subsidy on the sustainability of SWRO is still low, which is operates only 30% in a year. Further analysis shows that these subsidies actually be counter-productive to the sustainability of SWRO installation.

  9. VIRULENT GROUP Ro1,4 POTATO GOLDEN CYST NEMATODES (Globodera rostochiensis WOLLENWEBER IN CROATIA

    Directory of Open Access Journals (Sweden)

    Marija Ivezić

    2005-06-01

    Full Text Available The potato golden cyst nematode (Globodera rostochiensis WOLLENWEBER is very important potato pest. According to EPPO it is on the quarantines A2 list. This species was detected on the territory of Belice in 2001. In 2002 soil samples were taken on two treatments, one with potato in monoculture and the other on the wheat where potato was previous crop. Cysts extraction was done in the laboratory of nematology at the Faculty of Agriculture in Osijek and Swedish University of Agriculture Sciences, Department of Crop Science. Virulent group Ro1,4 was detected. More cysts were discovered in the monoculture potato soil (458/100 ccm of soil than in the soil under the wheat (368/100 ccm of soil. In 2004 vitality of the cysts were analysed. Cysts from potato monoculture had higher vitality (203 larvae/ cyst than cyst from the soil under wheat (38 larvae/cyst with potato as previous crop.

  10. Parametric theoretical study of a two-stage solar organic Rankine cycle for RO desalination

    Energy Technology Data Exchange (ETDEWEB)

    Kosmadakis, G.; Manolakos, D.; Papadakis, G. [Department of Natural Resources and Agricultural Engineering, Agricultural University of Athens, 75 Iera Odos Street, 11855 Athens (Greece)

    2010-05-15

    The present work concerns the parametric study of an autonomous, two-stage solar organic Rankine cycle for RO desalination. The main goal of the current simulation is to estimate the efficiency, as well as to calculate the annual mechanical energy available for desalination in the considered cases, in order to evaluate the influence of various parameters on the performance of the system. The parametric study concerns the variation of different parameters, without changing actually the baseline case. The effect of the collectors' slope and the total number of evacuated tube collectors used, have been extensively examined. The total cost is also taken into consideration and is calculated for the different cases examined, along with the specific fresh water cost (EUR/m{sup 3}). (author)

  11. Characterization of isolated polyamide thin films of RO and NF membranes using novel TEM techniques

    KAUST Repository

    Pacheco, Federico A.

    2010-08-15

    Achieving a better understanding of transport and rejection mechanisms in RO and NF membranes requires more detailed information of the nanostructure of polyamide thin films. This study reports on two novel transmission electron microscopy (TEM) techniques for characterizing polyamide nanostructure. The first technique produces cross-sectional images of isolated polyamide thin films by removing the polysulfone support from regular TEM cross-sections. In the second technique called " projected area" TEM (PA-TEM), isolated polyamide thin films are placed with their surface perpendicular to the electron beam. The resulting images capture the thickness, morphology and mass density of the entire thin film. In combination, these new techniques provide information on polyamide nanostructure that is not evident using conventional methods. For the commercial RO membrane ESPA3, the cross-sectional view of the isolated polyamide thin film shows a 30-60. nm thick base of nodular polyamide (presumably the separation barrier) that forms a relatively smooth interface with the polysulfone support. Above this, a more open structure of loose polyamide extends outward giving rise to the ridge-and-valley surface structure. In PA-TEM images, the ridges and valleys correspond to the dark and bright regions, respectively; the polyamide nodular base appears as round features forming an irregular honeycomb pattern throughout the images. Membrane cross-sections were prepared with a simple resin embedding protocol using the acrylic resin LR White. The protocol did not require dehydration steps, and was applicable to both dry and wet membrane samples. Artifacts that may be produced during sample preparation were also documented. © 2010 Elsevier B.V.

  12. Y a-t-il eu un instant zéro ?

    CERN Document Server

    Klein, Etienne

    2015-01-01

    D'où vient l'univers ? Et d'où vient même qu'il y ait un univers ? Aura-t-il une fin ? Pourquoi les humains y sont-ils apparus ? Si ces questions nous obsèdent depuis toujours, celle de l'origine demeure la plus mystérieuse, la plus vertigineuse, d'où la profusion de discours — mythologiques, religieux ou philosophiques — qui tentent d'y répondre. C'est grâce à la science, aux découvertes de Newton, Galilée, Edwin Hubble, Alexandre Friedmann et Georges Lemaître, qu'on peut retracer le grand récit de l'univers, remonter son histoire à 13,7 milliards d'années, jusqu'à cette phase très dense et très chaude qu'on a appelée le big bang. Mais celui-ci n'est pas pour autant, comme on l'a imaginé, cette explosion originelle qui aurait créé tout ce qui existe. Cet instant zéro, peut-on le décrire, le penser, raconter d'où il peut bien provenir ? Et d'où serait venu l'univers d'avant le big bang ? Mystère ! Qu'il y ait eu origine ou pas, on ne part donc jamais de zéro. En parler, c'est p...

  13. A 60GHz RoF(radio-over-fiber) transmission system based on PM modulator

    Science.gov (United States)

    Wang, Xin; Liu, Yi; Wang, Wen-Ting

    2016-11-01

    As one of the most important applications of microwave photonic ROF (Radio over Fiber) system which combines the advantages of optical communication and wireless communication is a good candidate for broadband mobile Communication In this paper, we built and simulation a 60GHz RoF(Radio-over-Fiber) transmission system based on PM modulator. First, we introduce the PM-IM(Phase modulation to intensity modulation) modulation mechanisms by the breaking the phase balanced approach. This method solves the problem that the constant envelope (phase modulation signal) generated by the phase modulator can not be directly detected by a photo detector. A standard single-mode fiber (SMF) is connected input to the F-P(Fabry-Perot) optical filter, which is to achieve the PM-IM modulation conversion by changing the wavelength of the laser or the frequency of the modulation factor of the F-P optical filter to adapt to different fiber lengths and the signal transmission rate. These two methods which changing the phase relationship between the optical carrier and the optical side band can realize the ideal phase transition to obtain efficient and low loss modulation conversion. Finally, the simulation results show that different fiber lengths and the signal transmission rate configuration of different wavelength of the laser or the frequency of the modulation factor of the F-P optical filter, the BER performance and the eye diagram of the 60GHz RoF transmission system signals have been improved based on these PM-IM modulation methods.

  14. RoHS regulated substances in mixed plastics from waste electrical and electronic equipment.

    Science.gov (United States)

    Wäger, Patrick A; Schluep, Mathias; Müller, Esther; Gloor, Rolf

    2012-01-17

    The disposal and recovery of plastics from waste electrical and electronic equipment (WEEE) are of considerable importance, both from an environmental and an economic perspective. This paper presents the results of a study investigating current concentrations of hazardous substances in mixed plastics from WEEE and their implications for an environmentally sound recovery. The study included 53 sampling campaigns for mixed plastics from WEEE. The samples were analyzed with regard to heavy metals (cadmium, chromium, mercury, and lead) and flame retardants (PentaBDE, OctaBDE, DecaBDE, DecaBB) regulated in the RoHS Directive. Besides these substances, other brominated flame retardants known to occur in electronics (HBCD, TBBPA) as well as the total bromine and phosphorus contents were considered. Results show that no mixed plastics fraction from WEEE is completely free from substances regulated in the RoHS Directive. The lowest number and average concentrations were found in flat screen monitors. The highest concentrations were found in mixed plastics from CRT monitors and TVs. Mixed plastics fractions with high average concentrations of heavy metals originate from the treatment of small household appliances (cadmium), ICT equipment (lead), and consumer equipment (lead). Mixed plastics fractions with high average concentrations of brominated flame retardants mainly originate from the treatment of small household appliances for high temperature applications (DecaBDE), CRT monitors (OctaBDE and DecaBDE) and consumer equipment (DecaBDE), in particular CRT TVs (DecaBDE). To avoid a dissipation of hazardous substances into plastics and the environment, it is recommended that mixed plastics from WEEE are subject to a strict quality management.

  15. The manipulation of massive ro-vibronic superpositions using time-frequency-resolved coherent anti-Stokes Raman scattering (TFRCARS) from quantum control to quantum computing

    CERN Document Server

    Zadoyan, R; Lidar, D A; Apkarian, V A

    2001-01-01

    Molecular ro-vibronic coherences, joint energy-time distributions of quantum amplitudes, are selectively prepared, manipulated, and imaged in Time-Frequency-Resolved Coherent Anti-Stokes Raman Scattering (TFRCARS) measurements using femtosecond laser pulses. The studies are implemented in iodine vapor, with its thermally occupied statistical ro-vibrational density serving as initial state. The evolution of the massive ro-vibronic superpositions, consisting of 1000 eigenstates, is followed through two-dimensional images. The first- and second-order coherences are captured using time-integrated frequency-resolved CARS, while the third-order coherence is captured using time-gated frequency-resolved CARS. The Fourier filtering provided by time integrated detection projects out single ro-vibronic transitions, while time-gated detection allows the projection of arbitrary ro-vibronic superpositions from the coherent third-order polarization. Beside the control and imaging of chemistry, the controlled manipulation of...

  16. Specific binding of benzodiazepines to human breast cancer cell lines.

    Science.gov (United States)

    Beinlich, A; Strohmeier, R; Kaufmann, M; Kuhl, H

    1999-01-01

    Binding of [3H]Ro5-4864, a peripheral benzodiazepine receptor (PBR) agonist, to BT-20 human, estrogen- (ER) and progesterone- (PR) receptor negative breast cancer cells was characterized. It was found to be specific, dose-dependent and saturable with a single population of binding sites. Dissociation constant (K(D)) was 8.5 nM, maximal binding capacity (Bmax) 339 fM/10(6) cells. Ro5-4864 (IC50 17.3 nM) and PK 11195 (IC50 12.3 nM) were able to compete with [3H]Ro5-4864 for binding, indicating specificity of interaction with PBR. Diazepam was able to displace [3H]Ro5-4864 from binding only at high concentrations (>1 microM), while ODN did not compete for PBR binding. Thymidine-uptake assay showed a biphasic response of cell proliferation. While low concentrations (100 nM) of Ro5-4864, PK 11195 and diazepam increased cell growth by 10 to 20%, higher concentrations (10-100 microM) significantly inhibited cell proliferation. PK 11195, a potent PBR ligand, was able to attenuate growth of BT-20 cells stimulated by 100 nM Ro5-4864 and to reverse growth reduction caused by 1 and 10 microM Ro5-4864, but not by 50 microM and 100 microM. This indicates that the antimitotic activity of higher concentrations of Ro5-4864 is independent of PBR binding. It is suggested, that PBR are involved in growth regulation of certain human breast cancer cell lines, possibly by supplying proliferating cells with energy, as their endogenous ligand is a polypeptide transporting Acyl-CoA.

  17. Temporal Spectral Analysis of Be stars observed with CoRoT satellite

    Science.gov (United States)

    Emilio, Marcelo; Janot Pacheco, Eduardo; Andrade, Laerte

    . Nevertheless, to measure frequencies with great accuracy in stars requires both high photometric precision and high time-frequency resolution. The CoRoT (Convection, Rotation and planetary Transits) satellite opens for the first time in history the possibility of fulfilling this goal. CoRoT is an experiment of astronomy dedicated to seismology and the detection of extrasolar planet transits. It was launched on December 2006 in an inertial polar orbit at an altitude of 897 mathrm{km}. The instrument is fed by a phi=27 textrm{cm} telescope. Its scientific program is three-fold consisting of: (1) The seismology core program (SISMO), which concerns the seismic study of ˜10 bright (6RoT ID 102761769 observed by CoRoT satellite. We found two close frequencies related to the .CoRoT ID 102761769 star. They are 2.465 c d(-1) (28.5 mathrm{mu Hz}) and 2.441 c d(-1) (28.2 mathrm{mu Hz}). The precision to which those frequencies were found is 0.018 c d(-1) (0.2 mathrm{mu Hz}). The projected stellar rotation was estimated to be 120 km s(-1) from the Fourier transform of spectral lines. If CoRoT-ID 102761769 is a typical Galactic Be star it rotates near the critical velocity. The critical rotation frequency of a typical B5-6 star is about 3.5 c d(-1) (40.5 mathrm{mu Hz}), which implies that the above frequencies are really caused by stellar pulsations rather than star's rotation. HD 171219 frequencies 1.113, 1.130, 1.146 c * d(-1) form a triplet with the

  18. The structure of disks around Herbig Ae/Be stars as traced by CO ro-vibrational emission

    NARCIS (Netherlands)

    van der Plas, G.; van den Ancker, M.E.; Waters, L.B.F.M.; Dominik, C.

    2015-01-01

    Aims. We study the emission and absorption of CO ro-vibrational lines in the spectra of intermediate mass pre-main-sequence stars with the aim to determine both the spatial distribution of the CO gas and its physical properties. We also aim to correlate CO emission properties with disk geometry.

  19. Triumfalnoje vozvrashtshenije 60-h / Airika Soome, Jaanika Sootna, Merike Pääro...[jt.] ; interv. Valeria Aru

    Index Scriptorium Estoniae

    2007-01-01

    Eesti tuntuimate kaubamärkide PTA, Monton, Bastion, Ivo Nikkolo ja Mosaic moekunstnike nägemused moest kevad-suveks 2007. PTA - Airika Soome, Monton - Jaanika Sootna, Bastion - Merike Pääro, Ivo Nikkolo - Eve Hanson ja Mosaic - Evelin Lill

  20. The CoRoT-GES Collaboration: Improving red giants spectroscopic surface gravitity and abundances with asteroseismology

    Science.gov (United States)

    Valentini, M.; Chiappini, C.; Miglio, A.; Montalbán, J.; Rodrigues, T.; Mosser, B.; Anders, F.; the CoRoT RG Group; GES Consortium, the

    2016-09-01

    Nowadays large spectroscopic surveys, like the Gaia-ESO Survey (GES), provide unique stellar databases for better investigating the formation and evolution of our Galaxy. Great attention must be paid to the accuracy of the basic stellar properties derived: large uncertainties in stellar parameters lead to large uncertainties in abundances, distances and ages. Asteroseismology has a key role in this context: when seismic information is combined with information derived from spectroscopic analysis, highly precise constraints on distances, masses, extinction and ages of red giants can be obtained. In the light of this promising joint action, we started the CoRoT-GES collaboration. We present a set of 1111 CoRoT stars, observed by GES from December 2011 to July 2014, these stars belong to the CoRoT field LRc01, pointing at the inner Galactic disk. Among these stars, 534 have reliable global seismic parameters. By combining seismic informations and spectroscopy, we derived precise stellar parameters, ages, kinematic and orbital parameters and detailed element abundances for this sample of stars. We also show that, thanks to asteroseismology, we are able to obtain a higher precision than what can be achieved by the standard spectroscopic means. This sample of CoRoT red giants, spanning Galactocentric distances from 5 to 8 kpc and a wide age interval (1-13 Gyr), provides us a representative sample for the inner disk population.

  1. Radiation thermo-chemical models of protoplanetary discs. IV. Modelling CO ro-vibrational emission from Herbig Ae discs

    NARCIS (Netherlands)

    Thi, W. F.; Kamp, I.; Woitke, P.; van der Plas, G.; Bertelsen, R.; Wiesenfeld, L.

    2013-01-01

    Context. The carbon monoxide (CO) ro-vibrational emission from discs around Herbig Ae stars and T Tauri stars with strong ultraviolet emissions suggests that fluorescence pumping from the ground X1Σ+ to the electronic A1Π state of CO should be taken into account in disc models. Aims: We wish to unde

  2. Radiation thermo-chemical models of protoplanetary discs IV. Modelling CO ro-vibrational emission from Herbig Ae discs

    NARCIS (Netherlands)

    Thi, W. F.; Kamp, I.; Woitke, P.; van der Plas, G.; Bertelsen, R.; Wiesenfeld, L.

    2013-01-01

    Context. The carbon monoxide (CO) ro-vibrational emission from discs around Herbig Ae stars and T Tauri stars with strong ultraviolet emissions suggests that fluorescence pumping from the ground X-1 Sigma(+) to the electronic A(1)Pi state of CO should be taken into account in disc models. Aims. We w

  3. Jumping the nuclear envelop barrier: Improving polyplex-mediated gene transfection efficiency by a selective CDK1 inhibitor RO-3306.

    Science.gov (United States)

    Zhou, Xuefei; Liu, Xiangrui; Zhao, Bingxiang; Liu, Xin; Zhu, Dingcheng; Qiu, Nasha; Zhou, Quan; Piao, Ying; Zhou, Zhuxian; Tang, Jianbin; Shen, Youqing

    2016-07-28

    Successful transfection of plasmid DNA (pDNA) requires intranuclear internalization of pDNA effectively and the nuclear envelope appears to be one of the critical intracellular barriers for polymer mediated pDNA delivery. Polyethylenimine (PEI), as the classic cationic polymer, compact the negatively charged pDNA tightly and make up stable polyplexes. The polyplexes are too large to enter the nuclear through nuclear pores and it is believed that the nuclear envelope breakdown in mitosis could facilitate the nuclear entry of polyplexes. To jump the nuclear envelope barrier, we used a selective and reversible CDK1 inhibitor RO-3306 to control the G2/M transition of the cell cycle and increased the proportion of mitotic cells which have disappeared nuclear envelope during transfection. Herein, we show that RO-3306 remarkably increases the transfection efficiency of PEI polyplexes through enhanced nuclear localization of PEI and pDNA. However, RO-3306 is less effective to the charge-reversal polymer poly[(2-acryloyl)ethyl(p-boronic acid benzyl)diethylammonium bromide] (B-PDEAEA) which responses to cellular stimuli and releases free pDNA in cytoplasm. Our findings not only offer new opportunities for improving non-viral based gene delivery but also provide theoretical support for the rational design of novel functional polymers for gene delivery. We also report current data showing that RO-3306 synergizes TRAIL gene induced apoptosis in cancer cells.

  4. ÜRO rääkis veel rahust, ent Bush ootas vaikides sõda / Neeme Raud

    Index Scriptorium Estoniae

    Raud, Neeme, 1969-

    2003-01-01

    Prantsusmaa, Venemaa, Saksamaa, Guinea ja Süüria välisministrid pidasid ÜRO-s Iraagi-teemalise eriistungi. USA presidendi George W. Bushi suhetest Iraagi sõja vastaste riikidega. Nimekiri riikidest, kes kuuluvad Iraagi-vastasesse ajutisse koalitsiooni

  5. Behaviour of RO98pHt polyamide membrane in reverse osmosis and low reverse osmosis conditions for phenol removal.

    Science.gov (United States)

    Hidalgo, A M; León, G; Gómez, M; Murcia, M D; Gómez, E; Gómez, J L

    2011-10-01

    Phenolic compounds and their derivatives are very common pollutants in wastewaters. Among the methods described for their removal, pressure-driven membrane processes are considered as a reliable alternative. Our research group has previously studied phenol removal in reverse osmosis (RO) conditions and obtained very low rejection percentages. Subsequently, when low reverse osmosis (LRO) conditions were studied, the organic rejection percentages improved. To further our knowledge in this respect, the main objective of this work was to study the behaviour of the polyamide thin-film composite membrane RO98pHt used for phenol removal in RO and LRO conditions. The influence of different operating pressures, phenol feed concentrations and pH on permeate flux and phenol rejection was studied. Low reverse osmosis conditions led to higher phenol rejection percentages in all the assayed conditions, suggesting that other factors related to the molecular characteristics of the organic molecules, such as solubility, acidity and hydrogen bonding capacity, play an important role in the rejection percentage attained. As expected, permeate flux was greater in RO conditions.

  6. Implementation of a GPS-RO data processing system for the KIAPS-LETKF data assimilation system

    Science.gov (United States)

    Kwon, H.; Kang, J.-S.; Jo, Y.; Kang, J. H.

    2015-03-01

    The Korea Institute of Atmospheric Prediction Systems (KIAPS) has been developing a new global numerical weather prediction model and an advanced data assimilation system. As part of the KIAPS package for observation processing (KPOP) system for data assimilation, preprocessing, and quality control modules for bending-angle measurements of global positioning system radio occultation (GPS-RO) data have been implemented and examined. The GPS-RO data processing system is composed of several steps for checking observation locations, missing values, physical values for Earth radius of curvature, and geoid undulation. An observation-minus-background check is implemented by use of a one-dimensional observational bending-angle operator, and tangent point drift is also considered in the quality control process. We have tested GPS-RO observations utilized by the Korean Meteorological Administration (KMA) within KPOP, based on both the KMA global model and the National Center for Atmospheric Research Community Atmosphere Model with Spectral Element dynamical core (CAM-SE) as a model background. Background fields from the CAM-SE model are incorporated for the preparation of assimilation experiments with the KIAPS local ensemble transform Kalman filter (LETKF) data assimilation system, which has been successfully implemented to a cubed-sphere model with unstructured quadrilateral meshes. As a result of data processing, the bending-angle departure statistics between observation and background show significant improvement. Also, the first experiment in assimilating GPS-RO bending angle from KPOP within KIAPS-LETKF shows encouraging results.

  7. Finest light curve details, physical parameters, and period fluctuations of CoRoT RR Lyrae stars

    Science.gov (United States)

    Benkő, J. M.; Szabó, R.; Derekas, A.; Sódor, Á.

    2016-12-01

    The CoRoT satellite supplied the scientific community with a huge data base of variable stars. Among them the RR Lyrae stars have intensively been discussed in numerous papers in the last few years, but the latest runs have not been checked to find RR Lyrae stars up to now. Our main goal was to fill this gap and complete the CoRoT RR Lyrae sample. We found nine unstudied RR Lyrae stars. Seven of them are new discoveries. We identified three new Blazhko stars. The Blazhko effect shows non-strictly repetitive nature for all stars. The frequency spectrum of the Blazhko star CoRoT 104948132 contains second overtone frequency with the highest known period ratio. The harmonic amplitude and phase declines with the harmonic order were studied for non-Blazhko stars. We found a period dependent but similar shape amplitude decline for all stars. We discovered significant random period fluctuation for one of the two oversampled target, CM Ori. After a successful transformation of the CoRoT band parameters to the Johnson V values we estimated the basic physical properties such as mass, luminosity, metallicity. The sample can be divided into two subgroups with respect to the metallicity but otherwise the physical parameters are in the canonical range of RR Lyrae stars.

  8. Finest light curve details, physical parameters, and period fluctuations of CoRoT RR Lyrae stars

    CERN Document Server

    Benkő, J M; Derekas, A; Sódor, Á

    2016-01-01

    The CoRoT satellite supplied the scientific community with a huge data base of variable stars. Among them the RR Lyrae stars have intensively been discussed in numerous papers in the last few years, but the latest runs have not been checked to find RR Lyrae stars up to now. Our main goal was to fill this gap and complete the CoRoT RR Lyrae sample. We found nine unstudied RR Lyrae stars. Seven of them are new discoveries. We identified three new Blazhko stars. The Blazhko effect shows non-strictly repetitive nature for all stars. The frequency spectrum of the Blazhko star CoRoT 104948132 contains second overtone frequency with the highest known period ratio. The harmonic amplitude and phase declines with the harmonic order were studied for non-Blazhko stars. We found a period dependent but similar shape amplitude decline for all stars. We discovered significant random period fluctuation for one of the two oversampled target, CM Ori. After a successful transformation of the CoRoT band parameters to the Johnson ...

  9. Young [$\\alpha$/Fe]-enhanced stars discovered by CoRoT and APOGEE: What is their origin?

    CERN Document Server

    Chiappini, C; Rodrigues, T S; Miglio, A; Montalban, J; Mosser, B; Girardi, L; Valentini, M; Noels, A; Morel, T; Minchev, I; Steinmetz, M; Santiago, B X; Schultheis, M; Martig, M; da Costa, L N; Maia, M A G; Prieto, C Allende; Peralta, R de Assis; Hekker, S; Themeßl, N; Kallinger, T; Garcia, R A; Mathur, S; Baudin, F; Beers, T C; Cunha, K; Harding, P; Holtzman, J; Majewski, S; Meszaros, Sz; Nidever, D; Pan, K; Schiavon, R P; Shetrone, M D; Schneider, D P; Stassun, K

    2015-01-01

    We report the discovery of a group of apparently young CoRoT red-giant stars exhibiting enhanced [alpha/Fe] abundance ratios (as determined from APOGEE spectra) with respect to Solar values. Their existence is not explained by standard chemical evolution models of the Milky Way, and shows that the chemical-enrichment history of the Galactic disc is more complex. We find similar stars in previously published samples for which isochrone-ages could be robustly obtained, although in smaller relative numbers, which could explain why these stars have not received prior attention. The young [alpha/Fe]-rich stars are much more numerous in the CoRoT-APOGEE (CoRoGEE) inner-field sample than in any other high-resolution sample available at present, as only CoRoGEE can explore the inner-disc regions and provide ages for its field stars. The kinematic properties of the young [$\\alpha$/Fe]-rich stars are not clearly thick-disc like, despite their rather large distances from the Galactic mid-plane. Our tentative interpretat...

  10. Beneficial phosphate recovery from reverse osmosis (RO) concentrate of an integrated membrane system using polymeric ligand exchanger (PLE).

    Science.gov (United States)

    Kumar, Manish; Badruzzaman, Mohammad; Adham, Samer; Oppenheimer, Joan

    2007-05-01

    Phosphorus (P) discharge to surface water is a major environmental problem. Wastewater treatment is targeted towards removal of this nutrient to prevent degradation of surface water. Integrated membrane systems (IMS) are increasingly being considered for wastewater reclamation, and provide excellent removal of P compounds. However, reverse osmosis (RO), which forms an integral part of these IMSs, concentrates most dissolved substances including P-species such as phosphates in the RO waste stream. In this study, removal of phosphate from this stream using polymeric ligand exchange (PLE) resins was investigated. Further, the possibility of phosphate recovery through struvite (MgNH(4)PO(4).6H(2)O) precipitation was tested. Struvite has been promoted as a slow release fertilizer in recent years. This study demonstrates that PLEs can be successfully used to remove phosphate from RO-concentrate, and to recover more than 85% of the adsorbed phosphorus from the exhausted media and precipitated as a beneficial product (struvite). The approach, presented in this study, suggests advantages of providing economic benefit from a waste product (RO) while avoiding phosphorus discharge to the environment.

  11. Fundamental properties of stars using asteroseismology from Kepler and CoRoT and interferometry from the CHARA Array

    DEFF Research Database (Denmark)

    Huber, D.; Ireland, M.J.; Bedding, T.R.;

    2012-01-01

    We present results of a long-baseline interferometry campaign using the PAVO beam combiner at the CHARA Array to measure the angular sizes of five main-sequence stars, one subgiant and four red giant stars for which solar-like oscillations have been detected by either Kepler or CoRoT. By combinin...

  12. Technical-Economic Analysis of Photovoltaik Reverse Osmosis Planning for Fulfillment of Fresh Water System on Ro-Pax Ship

    Directory of Open Access Journals (Sweden)

    Edi Jadmiko

    2017-09-01

    Full Text Available The need for fresh water in the world of industry is increasing with the rapid development of the global industry. The shipping industry is having a significant impact as part of a global industry concerning the sector of freshwater demand on ships. Freshwater supplies on ro-pax vessels are very important because they are the source of crew and passenger life when ships sail. Fulfillment of freshwater needs on a ro-pax vessel is made in a conventional system by filling clean water into a freshwater tank from the port. In this final project will be analyzed technical and economical on designing fresh water system using reverse osmosis system with solar panel as power supply and compare it with conventional system on ship KM. SABUK NUSANTARA 56. This Final Project includes installation design, size of fresh water tank, amount of cargo, investment cost and operational cost. The conclusion obtained in this final project is a reverse osmosis (RO system with solar panels as a very efficient power supply when applied to ro-pax ships such as ships KM SABUK NUSANTARA 56 because with this system the ship is able to produce their own fresh water, the size of the freshwater tank is smaller, for new shiploads can be increased. For the percentage of total cost of fresh water needs is dearer about 52 percent compared to conventional system and payload value increased 29.2 percent compared to conventional system.

  13. Tight ceramic UF membrane as RO pre-treatment: The role of electrostatic interactions on phosphate rejection

    NARCIS (Netherlands)

    Shang, R.; Verliefde, A.R.D.; Hu, J.; Zeng, Z.; Lu, L.; Kemperman, A.J.B.; Deng, H.; Nijmeijer, K.; Heijman, S.G.J.; Rietveld, L.C.

    2014-01-01

    Phosphate limitation has been reported as an effective approach to inhibit biofouling in reverse osmosis (RO) systems for water purification. The rejection of dissolved phosphate by negatively charged TiO2 tight ultrafiltration (UF) membranes (1 kDa and 3 kDa) was observed. These membranes can poten

  14. Measuring E(GSH) and H2O2 with roGFP2-based redox probes.

    Science.gov (United States)

    Morgan, Bruce; Sobotta, Mirko C; Dick, Tobias P

    2011-12-01

    Redox biochemistry plays an important role in a wide range of cellular events. However, investigation of cellular redox processes is complicated by the large number of cellular redox couples, which are often not in equilibrium with one another and can vary significantly between subcellular compartments and cell types. Further, it is becoming increasingly clear that different redox systems convey different biological information; thus it makes little sense to talk of an overall "cellular redox state". To gain a more differentiated understanding of cellular redox biology, quantitative, redox couple-specific, in vivo measurements are necessary. Unfortunately our ability to investigate specific redox couples or redox-reactive molecules with the necessary degree of spatiotemporal resolution is very limited. The development of genetically encoded redox biosensors offers a promising new way to investigate redox biology. Recently developed redox-sensitive green fluorescent proteins (roGFPs), genetically fused to redox-active proteins, allow rapid equilibration of the roGFP moiety with a specific redox couple. Two probes based on this principle are now available: Grx1-roGFP2 for the measurement of glutathione redox potential (E(GSH)) and roGFP2-Orp1 for measuring changes in H(2)O(2) concentration. Here we provide a detailed protocol for the use of these probes in both yeast and mammalian systems using either plate-reader- or microscopy-based measurements. Copyright © 2011 Elsevier Inc. All rights reserved.

  15. Gigabit close-proximity wireless connections supported by 60 GHz RoF links with low carrier suppression

    DEFF Research Database (Denmark)

    Lebedev, Alexander; Pang, Xiaodan; Vegas Olmos, Juan José

    2013-01-01

    We present an experimental investigation of the 60 GHz optical carrier suppressed radio over fiber systems with less than 5 dB carrier suppression. As a case study, the 60 GHz RoF signal is generated using a 12.5 Gb/s commercially available Mach-Zehnder modulator biased at its minimum point. We...

  16. CO ro-vibrational lines in HD100546: A search for disc asymmetries and the role of fluorescence

    CERN Document Server

    Bertelsen, R P Hein; Goto, M; van der Plas, G; Thi, W -F; Waters, L B F M; Ancker, M E van den; Woitke, P

    2013-01-01

    We have studied the emission of CO ro-vibrational lines in the disc around the Herbig Be star HD100546 with the final goal of using these lines as a diagnostic to understand inner disc structure in the context of planet formation. High-resolution IR spectra of CO ro-vibrational emission at eight different position angles were taken with CRIRES at the VLT. From these spectra flux tables, CO ro-vibrational line profiles, and population diagrams were produced. We have investigated variations in the line profile shapes and line strengths as a function of slit position angle. We used the thermochemical disc modelling code ProDiMo based on the chemistry, radiation field, and temperature structure of a previously published model for HD100546. Comparing observations and the model, we investigated the possibility of disc asymmetries, the excitation mechanism (UV fluorescence), the geometry, and physical conditions of the inner disc. The observed CO ro-vibrational lines are largely emitted from the inner rim of the out...

  17. Identifying the "true" radius of the hot sub-Neptune CoRoT-24b by mass loss modelling

    CERN Document Server

    Lammer, H; Fossati, L; Juvan, I; Odert, P; Cubillos, P E; Guenther, E; Kislyakova, K G; Johnstone, C P; Lueftinger, T; Guedel, M

    2016-01-01

    For the hot exoplanets CoRoT-24b and CoRoT-24c, observations have provided transit radii R$_{\\rm T}$ of 3.7$\\pm$0.4 R$_{\\oplus}$ and 4.9$\\pm$0.5 R$_{\\oplus}$, and masses of $\\le$5.7 M$_{\\oplus}$ and 28$\\pm$11 M$_{\\oplus}$, respectively. We study their upper atmosphere structure and escape applying an hydrodynamic model. Assuming R$_{\\rm T} \\approx$ R$_{\\rm PL}$, where R$_{\\rm PL}$ is the planetary radius at the pressure of 100 mbar, we obtained for CoRoT-24b unrealistically high thermally-driven hydrodynamic escape rates. This is due to the planet's high temperature and low gravity, independent of the stellar EUV flux. Such high escape rates could last only for $<$100 Myr, while R$_{\\rm PL}$ shrinks till the escape rate becomes less than or equal to the maximum possible EUV-driven escape rate. For CoRoT-24b, R$_{\\rm PL}$ must be therefore located at $\\approx 1.9-2.2$ R$_{\\oplus}$ and high altitude hazes/clouds possibly extinct the light at R$_{\\rm T}$. Our analysis constraints also the planet's mass to be ...

  18. Characterization of CoRoT target fields with BEST: Identification of periodic variable stars in the LRa1 field

    CERN Document Server

    Kabath, P; Erikson, A; Hedelt, P; Von Paris, P; Rauer, H; Renner, S; Titz, R; Wiese, T

    2009-01-01

    In this paper we report on observations of the CoRoT LRa1 field with the Berlin Exoplanet Search Telescope (BEST). The current paper is part of the series of papers describing the results of our stellar variability survey. BEST is a small aperture telescope with a wide field-of-view (FOV). It is dedicated to search for stellar variability within the target fields of the CoRoT space mission to aid in minimizing false-alarm rates and identify potential targets for additional science. The LRa1 field is CoRoT's third observed field and the second long run field located in the galactic anticenter direction. We observed the LRa1 stellar field on 23 nights between November and March 2005/2006. From 6099 stars marked as variable, 39 were classified as periodic variable stars and 27 of them are within the CoRoT FOV. We also confirmed the variability for 4 stars listed in GCVS catalog.

  19. Downregulation of (3H)Ro5-4864 binding sites after exposure to peripheral-type benzodiazepines in vitro

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, M.D.; Wang, J.K.; Morgan, J.I.; Spector, S.

    1986-09-01

    Peripheral-type benzodiazepine (BZD) binding sites undergo a rapid and pronounced downregulation after exposure to these compounds in vitro. Friend erythroleukemia cells were incubated with micromolar concentrations of BZD after which they were washed thoroughly and the binding of the specific peripheral-type BZD radioligand (/sup 3/H)Ro5-4864 was determined. Exposure to the peripheral-type BZD Ro7-3351 decreased the number of (/sup 3/H)Ro5-4864 binding sites from 324 to 41 fmol/10(6) cells with no change in affinity. Downregulation appears to require active cellular processes because it is blocked when exposure to BZD is at 4/sup 0/C rather than at 37/sup 0/C. Furthermore, whereas (/sup 3/H)Ro5-4864 binding is decreased substantially in membrane preparations made from downregulated cells, it is not altered when membrane preparations from control cells are exposed to BZD. The time course of downregulation is quite rapid, as it occurs within minutes. In contrast, the return of sites requires days and there is a close relationship between return of sites and growth of new cells. The ability of BZDs to downregulate correlates more closely with affinity for the peripheral-type site than with biological activity. The ability to undergo downregulation is characteristic of receptors and its occurrence suggests that peripheral-type BZD binding sites are functional receptors.

  20. En estil de fictes paraules que tenen sentits no fictes: anàlisi de locucions i col·locacions en Joan Roís de Corella en el context del llenguatge literari de la Corona d’Aragó en el segle XV

    Directory of Open Access Journals (Sweden)

    Martines, Vicent

    2015-06-01

    Full Text Available This paper presents a detailed analysis of a sample of phrases, collocations and other phraseological elements and order of significant words regarding the characterization of the flow of literary language in the work of Joan Roís de Corella. This analysis is based on an interdisciplinary methodology of the use of linguistic corpora, diachronic linguistics and IST (digital humanities applied to the analysis of the contribution of lexical and stylistic features by Roís de Corella in order to gauge the degree of his relevance as a classic.[ct] Aquest article presenta una mostra dels resultats de l’anàlisi detallada de locucions, col·locacions i altres elements fraseològics i d’ordre de mots significatius quant a la caracterització del cabal de llenguatge literari de Joan Roís de Corella. Aquesta anàlisi es fa amb metodologia interdisciplinar de base de lingüistica de corpus i de diacronia lingüistica, i amb el concurs de les tecnologies de la informació i la comunicació (humanitats digitals, que s’apliquen a l’anàlisi de l’aportació lèxica i estilística d’un autor clau com és Roís de Corella a fide calibrar el grau de sintonia i, alhora, d’especificitat del seu llenguatge literari; en quin grau coincideix el seu llenguatge literari amb el d’altres grans clàssics culturals de la Corona d’Aragó, i en què basa, alhora, Roís de Corella la clau de la seua mestria estilística.

  1. The dual RAF/MEK inhibitor CH5126766/RO5126766 may be a potential therapy for RAS-mutated tumor cells.

    Directory of Open Access Journals (Sweden)

    Makoto Wada

    Full Text Available Although melanoma is the most aggressive skin cancer, recent advances in BRAF and/or MEK inhibitors against BRAF-mutated melanoma have improved survival rates. Despite these advances, a treatment strategy targeting NRAS-mutated melanoma has not yet been elucidated. We discovered CH5126766/RO5126766 as a potent and selective dual RAF/MEK inhibitor currently under early clinical trials. We examined the activity of CH5126766/RO5126766 in a panel of malignant tumor cell lines including melanoma with a BRAF or NRAS mutation. Eight cell lines including melanoma were assessed for their sensitivity to the BRAF, MEK, or RAF/MEK inhibitor using in vitro growth assays. CH5126766/RO5126766 induced G1 cell cycle arrest in two melanoma cell lines with the BRAF V600E or NRAS mutation. In these cells, the G1 cell cycle arrest was accompanied by up-regulation of the cyclin-dependent kinase inhibitor p27 and down-regulation of cyclinD1. CH5126766/RO5126766 was more effective at reducing colony formation than a MEK inhibitor in NRAS- or KRAS-mutated cells. In the RAS-mutated cells, CH5126766/RO5126766 suppressed the MEK reactivation caused by a MEK inhibitor. In addition, CH5126766/RO5126766 suppressed the tumor growth in SK-MEL-2 xenograft model. The present study indicates that CH5126766/RO5126766 is an attractive RAF/MEK inhibitor in RAS-mutated malignant tumor cells including melanoma.

  2. Using [(11)C]Ro15 4513 PET to characterise GABA-benzodiazepine receptors in opiate addiction: Similarities and differences with alcoholism.

    Science.gov (United States)

    Lingford-Hughes, Anne; Myers, James; Watson, Ben; Reid, Alastair G; Kalk, Nicola; Feeney, Adrian; Hammers, Alexander; Riaño-Barros, Daniela A; McGinnity, Colm J; Taylor, Lindsay G; Rosso, Lula; Brooks, David J; Turkheimer, Federico; Nutt, David J

    2016-05-15

    The importance of the GABA-benzodiazepine receptor complex and its subtypes are increasingly recognised in addiction. Using the α1/α5 benzodiazepine receptor PET radioligand [(11)C]Ro15 4513, we previously showed reduced binding in the nucleus accumbens and hippocampus in abstinent alcohol dependence. We proposed that reduced [(11)C]Ro15 4513 binding in the nucleus accumbens was a marker of addiction whilst the reduction in hippocampus and positive relationship with memory was a consequence of chronic alcohol abuse. To examine this further we assessed [(11)C]Ro15 4513 binding in another addiction, opiate dependence, and used spectral analysis to estimate contributions of α1 and α5 subtypes to [(11)C]Ro15 4513 binding in opiate and previously acquired alcohol-dependent groups. Opiate substitute maintained opiate-dependent men (n=12) underwent an [(11)C]Ro15 4513 PET scan and compared with matched healthy controls (n=13). We found a significant reduction in [(11)C]Ro15 4513 binding in the nucleus accumbens in the opiate-dependent compared with the healthy control group. There was no relationship between [(11)C]Ro15 4513 binding in the hippocampus with memory. We found that reduced [(11)C]Ro15 4513 binding was associated with reduced α5 but not α1 subtypes in the opiate-dependent group. This was also seen in an alcohol-dependent group where an association between memory performance and [(11)C]Ro15 4513 binding was primarily driven by α5 and not α1 subtype. We suggest that reduced α5 levels in the nucleus accumbens are associated with addiction since we have now shown this in dependence to two pharmacologically different substances, alcohol and opiates.

  3. The roAp star α Circinus as seen by BRITE-Constellation

    Science.gov (United States)

    Weiss, W. W.; Fröhlich, H.-E.; Pigulski, A.; Popowicz, A.; Huber, D.; Kuschnig, R.; Moffat, A. F. J.; Matthews, J. M.; Saio, H.; Schwarzenberg-Czerny, A.; Grant, C. C.; Koudelka, O.; Lüftinger, T.; Rucinski, S. M.; Wade, G. A.; Alves, J.; Guedel, M.; Handler, G.; Mochnacki, St.; Orleanski, P.; Pablo, B.; Pamyatnykh, A.; Ramiaramanantsoa, T.; Rowe, J.; Whittaker, G.; Zawistowski, T.; Zocłońska, E.; Zwintz, K.

    2016-04-01

    We report on an analysis of high-precision, multi-colour photometric observations of the rapidly-oscillating Ap (roAp) star α Cir. These observations were obtained with the BRITE-Constellation, which is a coordinated mission of five nanosatellites that collects continuous millimagnitude-precision photometry of dozens of bright stars for up to 180 days at a time in two colours (≈Johnson B and R). BRITE stands for BRight Target Explorer. The object α Cir is the brightest roAp star and an ideal target for such investigations, facilitating the determination of oscillation frequencies with high resolution. This star is bright enough for complementary interferometry and time-resolved spectroscopy. Four BRITE satellites observed α Cir for146 d or 33 rotational cycles. Phasing the photometry according to the 4.4790 d rotational period reveals qualitatively different light variations in the two photometric bands. The phased red-band photometry is in good agreement with previously-published WIRE data, showing a light curve symmetric about phase 0.5 with a strong contribution from the first harmonic. The phased blue-lband data, in contrast, show an essentially sinusoidal variation. We model both light curves with Bayesian Photometric Imaging, which suggests the presence of two large-scale, photometrically bright (relative to the surrounding photosphere) spots. We also examine the high-frequency pulsation spectrum as encoded in the BRITE photometry. Our analysis establishes the stability of the main pulsation frequency over the last ≈20 yr, confirms the presence of frequency f7, which was not detected (or the mode not excited) prior to 2006, and excludes quadrupolar modes for the main pulsation frequency. Based on data collected by the BRITE-Constellation satellite mission, built, launched and operated thanks to support from the Austrian Aeronautics and Space Agency, the University of Vienna, the Canadian Space Agency (CSA), the Foundation for Polish Science

  4. Disentangling planetary and stellar activity features in the CoRoT-2 light curve

    Science.gov (United States)

    Bruno, G.; Deleuil, M.; Almenara, J.-M.; Barros, S. C. C.; Lanza, A. F.; Montalto, M.; Boisse, I.; Santerne, A.; Lagrange, A.-M.; Meunier, N.

    2016-11-01

    Aims: Stellar activity is an important source of systematic errors and uncertainties in the characterization of exoplanets. Most of the techniques used to correct for this activity focus on an ad hoc data reduction. Methods: We have developed a software for the combined fit of transits and stellar activity features in high-precision long-duration photometry. Our aim is to take advantage of the modelling to derive correct stellar and planetary parameters, even in the case of strong stellar activity. Results: We use an analytic approach to model the light curve. The code KSint, modified by adding the evolution of active regions, is implemented into our Bayesian modelling package PASTIS. The code is then applied to the light curve of CoRoT-2. The light curve is divided in segments to reduce the number of free parameters needed by the fit. We perform a Markov chain Monte Carlo analysis in two ways. In the first, we perform a global and independent modelling of each segment of the light curve, transits are not normalized and are fitted together with the activity features, and occulted features are taken into account during the transit fit. In the second, we normalize the transits with a model of the non-occulted activity features, and then we apply a standard transit fit, which does not take the occulted features into account. Conclusions: Our model recovers the activity features coverage of the stellar surface and different rotation periods for different features. We find variations in the transit parameters of different segments and show that they are likely due to the division applied to the light curve. Neglecting stellar activity or even only bright spots while normalizing the transits yields a 1.2σ larger and 2.3σ smaller transit depth, respectively. The stellar density also presents up to 2.5σ differences depending on the normalization technique. Our analysis confirms the inflated radius of the planet (1.475 ± 0.031RJ) found by other authors. We show that

  5. Chemistry of silica scale mitigation for RO desalination with particular reference to remote operations.

    Science.gov (United States)

    Milne, Nicholas A; O'Reilly, Tom; Sanciolo, Peter; Ostarcevic, Eddy; Beighton, Mark; Taylor, Kelvin; Mullett, Mark; Tarquin, Anthony J; Gray, Stephen R

    2014-11-15

    Silica scaling in reverse osmosis of groundwater is a significant issue in water stressed areas due to the limitations that scaling imposes on water recovery. While calcium and magnesium scaling potential can be significantly reduced by the use of ion exchange or other softening processes, the silica scaling potential typically remains. Improving the recovery of reverse osmosis by limiting the potential for silica scale is important in ensuring maximum water recovery. This is particularly important for mining and natural gas industries that are located in remote regions. The remote nature of these sites imposes three major restrictions on the silica scale mitigation process. Firstly, the generation of poorly dewaterable sludges must be avoided. Also, the quality of any reverse osmosis (RO) permeate must be able to meet the end use requirements, particularly for boilers. Finally, silica removal should not impact upon other potentially useful or valuable components within the brine, and should not make the disposal of the unusable waste brine components more difficult. Reduction of scaling potential can be achieved in three main ways: operating RO at high pH after hardness has been removed, operating at low pH, and reducing the silica concentration either in pretreatment or by using an interstage technique. Operating at high pH has the initial requirement of hardness removal to prevent scaling and this could be an issue on some sites. Hardness removal operations that use ion exchange resins may be challenged by water chemistry and the operational costs associated with high chemical regeneration costs. Operating at low pH may be more desirable than high pH operation as this can help to reduce the risk of scale formation from calcium or magnesium salts. The drawback comes from the cost of acid, particularly for high-alkalinity waters. There are numerous silica removal techniques including chemical dosing of lime, or aluminium or iron salts, electrocoagulation

  6. Standardization of vitrinite reflectance measurements in shale petroleum systems: How accurate are my Ro data?

    Science.gov (United States)

    Hackley, Paul C.

    2014-01-01

    Vitrinite reflectance generally is considered the most robust thermal maturity parameter available for application to hydrocarbon exploration and petroleum system evaluation. However, until 2011 there was no standardized methodology available to provide guidelines for vitrinite reflectance measurements in shale. Efforts to correct this deficiency resulted in publication of ASTM D7708-11: Standard test method for microscopical determination of the reflectance of vitrinite dispersed in sedimentary rocks. In 2012-2013, an interlaboratory exercise was conducted to establish precision limits for the measurement technique. Six samples, representing a wide variety of shale, were tested in duplicate by 28 analysts in 22 laboratories from 14 countries. Samples ranged from immature to overmature (Ro 0.31-1.53%), from organic-rich to organic-lean (1-22 wt.% total organic carbon), and contained Type I (lacustrine), Type II (marine), and Type III (terrestrial) kerogens. Repeatability values (difference between repetitive results from same operator, same conditions) ranged from 0.03-0.11% absolute reflectance, whereas reproducibility values (difference between results obtained on same test material by different operators, different laboratories) ranged from 0.12-0.54% absolute reflectance. Repeatability and reproducibility degraded consistently with increasing maturity and decreasing organic content. However, samples with terrestrial kerogens (Type III) fell off this trend, showing improved levels of reproducibility due to higher vitrinite content and improved ease of identification. Operators did not consistently meet the reporting requirements of the test method, indicating that a common reporting template is required to improve data quality. The most difficult problem encountered was the petrographic distinction of solid bitumens and low-reflecting inert macerals from vitrinite when vitrinite occurred with reflectance ranges overlapping the other components. Discussion among

  7. SDN based millimetre wave radio over fiber (RoF) network

    Science.gov (United States)

    Amate, Ahmed; Milosavljevic, Milos; Kourtessis, Pandelis; Robinson, Matthew; Senior, John M.

    2015-01-01

    This paper introduces software-defined, millimeter Wave (mm-Wave) networks with Radio over Fiber (RoF) for the delivery of gigabit connectivity required to develop fifth generation (5G) mobile. This network will enable an effective open access system allowing providers to manage and lease the infrastructure to service providers through unbundling new business models. Exploiting the inherited benefits of RoF, complete base station functionalities are centralized at the edges of the metro and aggregation network, leaving remote radio heads (RRHs) with only tunable filtering and amplification. A Software Defined Network (SDN) Central Controller (SCC) is responsible for managing the resource across several mm-Wave Radio Access Networks (RANs) providing a global view of the several network segments. This ensures flexible resource allocation for reduced overall latency and increased throughput. The SDN based mm-Wave RAN also allows for inter edge node communication. Therefore, certain packets can be routed between different RANs supported by the same edge node, reducing latency. System level simulations of the complete network have shown significant improvement of the overall throughput and SINR for wireless users by providing effective resource allocation and coordination among interfering cells. A new Coordinated Multipoint (CoMP) algorithm exploiting the benefits of the SCC global network view for reduced delay in control message exchange is presented, accounting for a minimum packet delay and limited Channel State Information (CSI) in a Long Term Evolution-Advanced (LTE-A), Cloud RAN (CRAN) configuration. The algorithm does not require detailed CSI feedback from UEs but it rather considers UE location (determined by the eNB) as the required parameter. UE throughput in the target sector is represented using a Cumulative Distributive Function (CDF). The drawn characteristics suggest that there is a significant 60% improvement in UE cell edge throughput following the

  8. Astrobiology Road Mapping (AstRoMap) - A project within FP7 of the European Commission: First results

    Science.gov (United States)

    Gomez-Gomez, Felipe; Capria, Maria Teresa; Palomba, Ernesto; Walter, Nicolas; Rettberg, Petra; Muller, Christian; Horneck, Gerda

    AstRoMap (Astrobiology and Planetary Exploration Road Mapping) is a funded project formulated in the 5th Call of the European Commission FP7 framework. The main objectives of the AstRoMap are: 1. Identify the main astrobiology issues to be addressed by Europe in the next decades in relation with space exploration 2. Identify potential mission concepts that would allow addressing these issues 3. Identify the technology developments required to enable these missions 4. Provide a prioritized roadmap integrating science and technology activities as well as ground-based approach 5. Map scientific knowledge related to astrobiology in Europe To reach those objectives, AstRoMap is executed within the following steps: 1. Community consultation. In order to map the European astrobiology landscape and to provide a collaborative networking platform for this community, the AstRoMap project hosts a database of scientists (European and beyond) interested in astrobiology and planetary exploration (see: http://www.astromap.eu/database.html). It reflects the demography and the research and teaching activities of the astrobiology community, as well as their professional profiles and involvement in astrobiology projects. Considering future aspects of astrobiology in Europe, the need for more astrobiology-dedicated funding programmes at the EU level, especially for cross-disciplinary groups, was stressed. This might eventually lead to the creation of a European laboratory of Astrobiology, or even of a European Astrobiology Institute. 2. Workshops organisation. On the basis of the feedbacks from the community consultation, the potential participants and interesting topics are being identified to take part in the following workshops: 1-. Origin of organic compounds, steps to life; 2. Physico-chemical boundary conditions for habitability 3. Biosignatures as facilitating life detection 4. Origin of the Solar system 3. Astrobiology road-mapping. Based on the results and major conclusions

  9. An investigation of desalination by nanofiltration, reverse osmosis and integrated (hybrid NF/RO) membranes employed in brackish water treatment.

    Science.gov (United States)

    Talaeipour, M; Nouri, J; Hassani, A H; Mahvi, A H

    2017-01-01

    As an appropriate tool, membrane process is used for desalination of brackish water, in the production of drinking water. The present study aims to investigate desalination processes of brackish water of Qom Province in Iran. This study was carried out at the central laboratory of Water and Wastewater Company of the studied area. To this aim, membrane processes, including nanofiltration (NF) and reverse osmosis (RO), separately and also their hybrid process were applied. Moreover, water physical and chemical parameters, including salinity, total dissolved solids (TDS), electric conductivity (EC), Na(+1) and Cl(-1) were also measured. Afterward, the rejection percent of each parameter was investigated and compared using nanofiltration and reverse osmosis separately and also by their hybrid process. The treatment process was performed by Luna domestic desalination device, which its membrane was replaced by two NF90 and TW30 membranes for nanofiltration and reverse osmosis processes, respectively. All collected brackish water samples were fed through membranes NF90-2540, TW30-1821-100(RO) and Hybrid (NF/RO) which were installed on desalination household scale pilot (Luna water 100GPD). Then, to study the effects of pressure on permeable quality of membranes, the simulation software model ROSA was applied. Results showed that percent of the salinity rejection was recorded as 50.21%; 72.82 and 78.56% in NF, RO and hybrid processes, respectively. During the study, in order to simulate the performance of nanofiltartion, reverse osmosis and hybrid by pressure drive, reverse osmosis system analysis (ROSA) model was applied. The experiments were conducted at performance three methods of desalination to remove physic-chemical parameters as percentage of rejections in the pilot plant are: in the NF system the salinity 50.21, TDS 43.41, EC 43.62, Cl 21.1, Na 36.15, and in the RO membrane the salinity 72.02, TDS 60.26, EC 60.33, Cl 43.08, Na 54.41. Also in case of the rejection

  10. Current Status, Problems and Countermeasures of Ro-ro Transportation of Sedan Cars in Shenzhen%深圳轿车滚装运输发展的现状、问题和对策

    Institute of Scientific and Technical Information of China (English)

    胡延华

    2014-01-01

    In this paper, we pointed out the merits of the ro-ro practice in the transportation of sedan cars, then analyzed the problems to be solved in the development of this practice in Shenzhen, and at the end, proposed the specific solutions.%指出轿车滚装运输因运送数量大、安全、经济、便捷、环保,目前已经成为世界趋势。深圳轿车滚装运输需求巨大、拥有全国最早经营国内滚装业务且业务量最大的企业,但目前深圳轿车滚装运输仍存在诸多问题亟待解决,最后提出了相应的解决方案。

  11. Synchronous Effect of Slipping Heavy Loads on a Ro-Ro Ship Rolling in Waves%滚装船在波浪中横摇时船上滑动重载荷的同步效应

    Institute of Scientific and Technical Information of China (English)

    张银龙; 沈庆; 陈徐均

    2005-01-01

    When a heavy load such as a vehicle slips freely on a ro-ro ship due to malfunction of its securing device, the heavy load slipping on deck will become more and more with the time going on because of repeated collision. Common effect of wave and slip of internal vehicles will induce serious rolling of the roll-on ship. This is one of the important reasons for overturn of the ro-ro ships.The multibody system with a floating base is composed of ro-ro ship and two slipping vehicles.This paper takes the rolling angle of the ship and the transverse displacements of the two slipping vehicles on deck as three degrees of freedom. Making use of dynamic method of multibody system, dynamic equations of the system are established.Taking a certain channel ferry as an example, numerical calculations were carried out for rolling response of the multibody system with a floating base of a ro-ro ship and displacements response of the two slipping vehicles under both effects of free slipping vehicles and wave,and a conclusion was drawn that the motion of the numerous free slipping heavy loads may lead to be synchronous under restraining of the side-wall bulkhead with the time going on because of repeated collision.%滚装船中车辆等重载荷由于固定装置失效而随船摇荡作自由滑动时,往往由于反复碰撞致使在甲板上作自由滑动的重载荷随着时间增多.由于波浪和内部滑动车辆共同作用,使滚装船的横摇加剧.这是许多滚装船发生倾覆的重要原因之一.本文对由滚装船和两辆滑动车辆组成的浮基多体系统,取滚装船的横摇角和两辆自由滑动车辆在甲板上的横向位移为此系统的三个自由度,运用多体系统动力学方法,建立了系统的动力学方程.以某型海峡滚装渡轮为例,对在两辆车自由滑动和波浪共同作用下的滚装船浮基多体系统的横摇响应和车辆位移响应进行了数值计算,得出了多个自由滑动的重载荷因相互碰撞在

  12. 基于RoF技术的下一代楼宇无线通信系统研究%Research on In-building Wireless System with RoF Technology

    Institute of Scientific and Technical Information of China (English)

    殷杰

    2009-01-01

    光载无线通信技术(Radio-over-Fiber)具有光纤通信和无线通信的优点,它是通信系统中"最后一英里"的有效解决方案.在楼宇无线通信中,RoF技术正得到越来越多的应用.毫米波RoF系统可提供更大的带宽,是一种适应未来信息传输模式的楼内无线接入方式,并且正向其它行业渗透和发展.

  13. The Berlin Exoplanet Search Telescope II Catalog of Variable Stars. II. Characterization of the CoRoT SRc02 field

    CERN Document Server

    Klagyivik, P; Pasternacki, T; Cabrera, J; Chini, R; Eigmüller, P; Erikson, A; Fruth, T; Kabath, P; Lemke, R; Murphy, M; Rauer, H; Titz-Weider, R

    2015-01-01

    Time-series photometry of the CoRoT field SRc02 was obtained by the Berlin Exoplanet Search Telescope II (BEST II) in 2009. The main aim was the ground based follow-up of the CoRoT field in order to detect variable stars with better spatial resolution than what can be achieved with the CoRoT space telescope. A total of 1,846 variable stars were detected, of which only 30 have been previously known. For nine eclipsing binaries the stellar parameters were determined by modeling their light curve.

  14. Integrated removal of inorganic contaminants from acid mine drainage using BOF slag, lime, soda ash and reverse osmosis (RO): Implication for the production of drinking water

    CSIR Research Space (South Africa)

    Masindi, Vhahangwele

    2017-06-01

    Full Text Available , Finland IMWA 2017Mine Water and Circular Economy Wolkersdorfer C, Sartz L, Sillanpää M, Häkkinen A (Editors) Integrated removal of inorganic contaminants from Acid Mine Drainage using BOF Slag, Lime, Soda ash and Reverse Osmosis (RO): Implication... was reduced from 18000 to 4000 mg/L hence requiring another purification technology. Hardness was reduced using lime and soda ash. Reverse Osmosis (RO) was used to further clean the water to drinking standard. A single pass two element RO system...

  15. Transiting exoplanets from the CoRoT space mission XXVIII. CoRoT-33b, an object in the brown dwarf desert with 2:3 commensurability with its host star

    CERN Document Server

    Csizmadia, Sz; Gandolfi, G; Deleuil, M; Bouchy, M; Fridlund, M; Szabados, L; Parviainen, H; Cabrera, J; Aigrain, S; Alonso, R; Almenara, J M; Baglin, A; Bordé, P; Bonomo, A S; Deeg, H J; Dıaz, R F; Erikson, A; Ferraz-Mello, S; Santos, M Tadeu dos; Guenther, E W; Guillot, T; Grziwa, S; Hébrard, G; Klagyivik, P; Ollivier, M; Pätzold, M; Rauer, H; Rouan, D; Santerne, A; Schneider, J; Mazeh, T; Wuchterl, G; Carpano, S; Ofir, A

    2015-01-01

    We report the detection of a rare transiting brown dwarf with a mass of 59 M_Jup and radius of 1.1 R_Jup around the metal-rich, [Fe/H] = +0.44, G9V star CoRoT-33. The orbit is eccentric (e = 0.07) with a period of 5.82 d. The companion, CoRoT-33b, is thus a new member in the so-called brown dwarf desert. The orbital period is within 3% to a 3:2 resonance with the rotational period of the star. CoRoT-33b may be an important test case for tidal evolution studies. The true frequency of brown dwarfs close to their host stars (P < 10 d) is estimated to be approximately 0.2% which is about six times smaller than the frequency of hot Jupiters in the same period range. We suspect that the frequency of brown dwarfs declines faster with decreasing period than that of giant planets.

  16. A circumbinary disc model for the variability of the eclipsing binary CoRoT 223992193

    CERN Document Server

    Terquem, Caroline; Bouvier, Jérôme

    2015-01-01

    We calculate the flux received from a binary system obscured by a circumbinary disc. The disc is modelled using two dimensional hydrodynamical simulations, and the vertical structure is derived by assuming it is isothermal. The gravitational torque from the binary creates a cavity in the disc's inner parts. If the line of sight along which the system is observed has a high inclination $I$, it intersects the disc and some absorption is produced. As the system is not axisymmetric, the resulting light curve displays variability. We calculate the absorption and produce light curves for different values of the dust disc aspect ratio $H/r$ and mass of dust in the cavity $M_{\\rm dust}$. This model is applied to the high inclination ($I=85^{\\circ}$) eclipsing binary CoRoT 223992193, which shows 5-10% residual photometric variability after the eclipses and a spot model are subtracted. We find that such variations for $I \\sim 85^{\\circ}$ can be obtained for $H/r=10^{-3}$ and $M_{\\rm dust} \\ge 10^{-12}$ M$_{\\odot}$. For...

  17. Ro-vibrational excitation of an organic molecule (HCN) in protoplanetary disks

    CERN Document Server

    Bruderer, Simon; van Dishoeck, Ewine F

    2014-01-01

    (Abridged) Organic molecules are important constituents of protoplanetary disks. Their ro-vibrational lines observed in the near- and mid-infrared are commonly detected toward T Tauri disks. These lines are the only way to probe the chemistry in the inner few au where terrestrial planets form. To understand this chemistry, accurate molecular abundances have to be determined. This is complicated by excitation effects. Most analyses so far have made the assumption of local thermal equilibrium (LTE). Starting from estimates for the collisional rate coefficients of HCN, non-LTE slab models of the HCN emission were calculated to study the importance of different excitation mechanisms. Using a new radiative transfer model, the HCN emission from a full two-dimensional disk was then modeled to study the effect of the non-LTE excitation, together with the line formation. We ran models tailored to the T Tauri disk AS 205 (N) where HCN lines in both the 3 {\\mu}m and 14 {\\mu}m bands have been observed by VLT-CRIRES and t...

  18. Variability in the CO ro-vibrational lines from HD163296

    CERN Document Server

    Bertelsen, Rosina P Hein; van der Plas, G; Ancker, M E van den; Waters, L B F M; Thi, W -F; Woitke, P

    2016-01-01

    We present for the first time a direct comparison of multi-epoch (2001-2002 and 2012) CO ro-vibrational emission lines from HD163296. We find that both the line shapes and the FWHM (Full Width Half Maximum) differ between these two epochs. The FWHM of the median observed line profiles are 10-25 km/s larger in the earlier epoch, and confirmed double peaks are only present in high J lines from 2001-2002. The line wings of individual transitions are similar in the two epochs making an additional central component in the later epoch a likely explanation for the single peaks and the lower FWHM. Variations in NIR brightness have been reported and could be linked to the observed variations. Additionally, we use the thermo chemical disc code ProDiMo to compare for the first time the line shapes, peak separations, FWHM, and line fluxes, to those observed. The ProDiMo model reproduces the peak separations, and low and mid J line fluxes well. The FWHM however, are over predicted and high J line fluxes are under predicte...

  19. KIC 4768731: a bright long-period roAp star in the Kepler Field

    CERN Document Server

    Smalley, B; Murphy, S J; Lehmann, H; Kurtz, D W; Holdsworth, D L; Cunha, M S; Balona, L A; Briquet, M; Bruntt, H; de Cat, P; Lampens, P; Thygesen, A O; Uytterhoeven, K

    2015-01-01

    We report the identification of 61.45 d^-1 (711.2 mu Hz) oscillations, with amplitudes of 62.6-mu mag, in KIC 4768731 (HD 225914) using Kepler photometry. This relatively bright (V=9.17) chemically peculiar star with spectral type A5 Vp SrCr(Eu) has previously been found to exhibit rotational modulation with a period of 5.21 d. Fourier analysis reveals a simple dipole pulsator with an amplitude that has remained stable over a 4-yr time span, but with a frequency that is variable. Analysis of high-resolution spectra yields stellar parameters of T_eff = 8100 +/- 200 K, log g = 4.0 +/- 0.2, [Fe/H] = +0.31 +/- 0.24 and v sin i = 14.8 +/- 1.6 km/s. Line profile variations caused by rotation are also evident. Lines of Sr, Cr, Eu, Mg and Si are strongest when the star is brightest, while Y and Ba vary in anti-phase with the other elements. The abundances of rare earth elements are only modestly enhanced compared to other roAp stars of similar T_eff and log g. Radial velocities in the literature suggest a significant...

  20. Planetary eclipse mapping of CoRoT-2a. Evolution, differential rotation, and spot migration

    CERN Document Server

    Huber, K F; Wolter, U; Schmitt, J H M M

    2010-01-01

    The lightcurve of CoRoT-2 shows substantial rotational modulation and deformations of the planet's transit profiles caused by starspots. We consistently model the entire lightcurve, including both rotational modulation and transits, stretching over approximately 30 stellar rotations and 79 transits. The spot distribution and its evolution on the noneclipsed and eclipsed surface sections are presented and analyzed, making use of the high resolution achievable under the transit path. We measure the average surface brightness on the eclipsed section to be (5\\pm1) % lower than on the noneclipsed section. Adopting a solar spot contrast, the spot coverage on the entire surface reaches up to 19 % and a maximum of almost 40 % on the eclipsed section. Features under the transit path, i.e. close to the equator, rotate with a period close to 4.55 days. Significantly higher rotation periods are found for features on the noneclipsed section indicating a differential rotation of $\\Delta \\Omega > 0.1$. Spotted and unspotted...

  1. RoPEUS: A New Robust Algorithm for Static Positioning in Ultrasonic Systems

    Directory of Open Access Journals (Sweden)

    Christophe Croux

    2009-06-01

    Full Text Available A well known problem for precise positioning in real environments is the presence of outliers in the measurement sample. Its importance is even bigger in ultrasound based systems since this technology needs a direct line of sight between emitters and receivers. Standard techniques for outlier detection in range based systems do not usually employ robust algorithms, failing when multiple outliers are present. The direct application of standard robust regression algorithms fails in static positioning (where only the current measurement sample is considered in real ultrasound based systems mainly due to the limited number of measurements and the geometry effects. This paper presents a new robust algorithm, called RoPEUS, based on MM estimation, that follows a typical two-step strategy: 1 a high breakdown point algorithm to obtain a clean sample, and 2 a refinement algorithm to increase the accuracy of the solution. The main modifications proposed to the standard MM robust algorithm are a built in check of partial solutions in the first step (rejecting bad geometries and the off-line calculation of the scale of the measurements. The algorithm is tested with real samples obtained with the 3D-LOCUS ultrasound localization system in an ideal environment without obstacles. These measurements are corrupted with typical outlying patterns to numerically evaluate the algorithm performance with respect to the standard parity space algorithm. The algorithm proves to be robust under single or multiple outliers, providing similar accuracy figures in all cases.

  2. 新奥特公司顺利通过RoHS认证

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    新奥特公司相关产品顺利通过了由PONY谱尼测试承担的各项检测环节,取得了由其出具的《检测报告》,并即将获得由CQC(中国质量认证中心)颁发的CQC RoHS证书。这标志着新奥特公司已经成为中国制造绿色电子产品,与国际标准接轨的践行者。此次为新奥特公司产品提供检测服务的PONY谱尼测试是检测服务网络遍及全球的大型跨国集团,检测报告得到美国、英国、德国等62个国家和地区互认,

  3. Pulsations in the atmosphere of the roAp star HD 24712 II. Theoretical models

    CERN Document Server

    Saio, Hideyuki; Sachkov, Mikhail

    2009-01-01

    We discuss pulsations of the rapidly oscillating Ap (roAp) star HD 24712 (HR 1217) based on nonadiabatic analyses taking into account the effect of dipole magnetic fields. We have found that all the pulsation modes appropriate for HD 24712 are damped; i.e., the kappa-mechanism excitation in the hydrogen ionization layers is not strong enough to excite high-order p-modes with periods consistent with observed ones, all of which are found to be above the acoustic cut-off frequencies of our models. The main (2.721 mHz) and the highest (2.806 mHz) frequencies are matched with modified $l=2$ and $l=3$ modes, respectively. The large frequency separation ($\\approx 68 \\mu$Hz) is reproduced by models which lay within the error box of HD 24712 on the HR diagram. The nearly equally spaced frequencies of HD 24712 indicate the small frequency separation to be as small as $\\approx 0.5\\mu$Hz. However, the small separation derived from theoretical $l=1$ and 2 modes are found to be larger than $\\sim 3\\mu$Hz. The problem of equ...

  4. A Study of Ro-vibrational OH Emission from Herbig Ae/Be Stars

    CERN Document Server

    Brittain, Sean D; Carr, John S; Ádámkovics, Máté; Reynolds, Nickalas

    2016-01-01

    We present a study of ro-vibrational OH and CO emission from 21 disks around Herbig Ae/Be stars. We find that the OH and CO luminosities are proportional over a wide range of stellar ultraviolet luminosities. The OH and CO line profiles are also similar, indicating that they arise from roughly the same radial region of the disk. The CO and OH emission are both correlated with the far-ultraviolet luminosity of the stars, while the PAH luminosity is correlated with the longer wavelength ultraviolet luminosity of the stars. Although disk flaring affects the PAH luminosity, it is not a factor in the luminosity of the OH and CO emission. These properties are consistent with models of UV-irradiated disk atmospheres. We also find that the transition disks in our sample, which have large optically thin inner regions, have lower OH and CO luminosities than non-transition disk sources with similar ultraviolet luminosities. This result, while tentative given the small sample size, is consistent with the interpretation t...

  5. RO 90-7501 enhances TLR3 and RLR agonist induced antiviral response.

    Directory of Open Access Journals (Sweden)

    Fang Guo

    Full Text Available Recognition of virus infection by innate pattern recognition receptors (PRRs, including membrane-associated toll-like receptors (TLR and cytoplasmic RIG-I-like receptors (RLR, activates cascades of signal transduction pathways leading to production of type I interferons (IFN and proinflammatory cytokines that orchestrate the elimination of the viruses. Although it has been demonstrated that PRR-mediated innate immunity plays an essential role in defending virus from infection, it also occasionally results in overwhelming production of proinflammatory cytokines that cause severe inflammation, blood vessel leakage and tissue damage. In our efforts to identify small molecules that selectively enhance PRR-mediated antiviral, but not the detrimental inflammatory response, we discovered a compound, RO 90-7501 ('2'-(4-Aminophenyl-[2,5'-bi-1H-benzimidazol]-5-amine, that significantly promoted both TLR3 and RLR ligand-induced IFN-β gene expression and antiviral response, most likely via selective activation of p38 mitogen-activated protein kinase (MAPK pathway. Our results thus imply that pharmacological modulation of PRR signal transduction pathways in favor of the induction of a beneficial antiviral response can be a novel therapeutic strategy.

  6. Plaskett's Star: Analysis of the CoRoT photometric data

    CERN Document Server

    Mahy, L; Baudin, F; Rauw, G; Godart, M; Morel, T; Degroote, P; Aerts, C; Blomme, R; Cuypers, J; Noels, A; Michel, E; Baglin, A; Auvergne, M; Catala, C; Samadi, R

    2010-01-01

    The SRa02 of the CoRoT space mission for Asteroseismology was partly devoted to stars belonging to the Mon OB2 association. An intense monitoring was performed on Plaskett's Star (HD47129) and the unprecedented quality of the light curve allows us to shed new light on this very massive, non-eclipsing binary system. We particularly aimed at detecting periodic variability which might be associated with pulsations or interactions between both components. We also searched for variations related to the orbital cycle which could help to constrain the inclination and the morphology of the binary system. A Fourier-based prewhitening and a multiperiodic fitting procedure were applied to analyse the time series and extract the frequencies of variations. We describe the noise properties to tentatively define an appropriate significance criterion, to only point out the peaks at a certain significance level. We also detect the variations related to the orbital motion and study them by using the NIGHTFALL program. The peri...

  7. THE SOCIO-POLITICAL LEXICON IN THE POETRY OF THE ALBANIAN WRITER DRITËRO AGOLLI

    Directory of Open Access Journals (Sweden)

    Sashenka Kamberi

    2014-06-01

    Full Text Available Dritëro Agolli is one of the best-known poets of contemporary Albanian literature. He is a prolific writer despite the fact that he began writing in early youth. His early verse collections in late 50s introduced him to the public as a gifted writer together with I. Kadare. In addition to being a writer, he has been one of the most active members in the socio-political life of the country, identifying himself as a writer affiliated with a political party who put his talent to good use when it came to ideological issues. He strongly believed in “the communist ideal” on which he had pinned his dreams about himself and his country.In this article we will talk about the lexicon he uses in his creations which feature party content. Since it is impossible to analyze his whole work we will concentrate on two such typical works written in different political periods, the poem “Mother Albania” (1974 and the volume “The Belated Pilgrim” (1993. Our aim is not merely to highlight the socio-political lexicon he uses, but also through analyses to show its function in his poetry and the mastery of the poet to transform it into a source of expression. Despite the penumbras that have accompanied the writer’s high standing and his poetry, he remains one of the poets who, despite his political commitments, elevated Albanian poetry to new heights.

  8. Autoantigen TRIM21/Ro52 as a Possible Target for Treatment of Systemic Lupus Erythematosus

    Directory of Open Access Journals (Sweden)

    Ryusuke Yoshimi

    2012-01-01

    Full Text Available Systemic lupus erythematosus (SLE is a chronic, systemic, and autoimmune disease, whose etiology is still unknown. Although there has been progress in the treatment of SLE through the use of glucocorticoid and immunosuppressive drugs, these drugs have limited efficacy and pose significant risks of toxicity. Moreover, prognosis of patients with SLE has remained difficult to assess. TRIM21/Ro52/SS-A1, a 52-kDa protein, is an autoantigen recognized by antibodies in sera of patients with SLE and Sjögren's syndrome (SS, another systemic autoimmune disease, and anti-TRIM21 antibodies have been used as a diagnostic marker for decades. TRIM21 belongs to the tripartite motif-containing (TRIM super family, which has been found to play important roles in innate and acquired immunity. Recently, TRIM21 has been shown to be involved in both physiological immune responses and pathological autoimmune processes. For example, TRIM21 ubiquitylates proteins of the interferon-regulatory factor (IRF family and regulates type I interferon and proinflammatory cytokines. In this paper, we summarize molecular features of TRIM21 revealed so far and discuss its potential as an attractive therapeutic target for SLE.

  9. The CoRoT satellite in flight : description and performance

    CERN Document Server

    Auvergne, M; Boisnard, L; Buey, J -T; Chaintreuil, S

    2009-01-01

    CoRoT is a space telescope dedicated to stellar seismology and the search for extrasolar planets. The mission is led by CNES in association with French laboratories and has a large international participation: the European Space Agency (ESA), Austria, Belgium and Germany contribute to the payload, and Spain and Brazil contribute to the ground segment. Development of the spacecraft, which is based on a PROTEUS low earth orbit recurrent platform, commenced in October 2000 and the satellite was launched on December 27th 2006. The instrument and platform characteristics prior to launch have been described in ESA publication (SP-1306) . In the present paper we detail the behaviour in flight, based on raw and corrected data. Five runs have been completed since January 2007. The data used here are essentially those acquired during the commissioning phase and from a long run which lasted 146 days, these enable us to give a complete overview of the instrument and platform behaviour for all environmental conditions. Th...

  10. KIC 7582608: a new Kepler roAp star with frequency variability

    Directory of Open Access Journals (Sweden)

    Holdsworth D.L.

    2015-01-01

    Full Text Available We analyse the fifth roAp star reported in the Kepler field, KIC 7582608, discovered with the SuperWASP project. The object shows a high frequency pulsation at 181.7324d−1 (P = 7.9 min with an amplitude of 1.45 mmag, and low frequency rotational modulation corresponding to a period of 20.4339 d. Spectral analysis confirms the Ap nature of the target, with characteristic lines of rare earth elements present. From our spectral observations we derive a lower limit on the mean magnetic field modulus of 〈B〉 =3.05 ± 0.23 kG. Long Cadence Kepler observations show a frequency quintuplet split by the rotational period of the star, typical for an oblique pulsator. We suggest the star is a quadrupole pulsator with a geometry such that i ~ 66° and β ~ 33°. We detect frequency variations of the pulsation in both the WASP and Kepler data sets on many time scales. Linear, non-adiabatic stability modelling allows us to constrain a region on the HR diagram where the pulsations are unstable, an area consistent with observations.

  11. The changing phases of extrasolar planet CoRoT-1b.

    Science.gov (United States)

    Snellen, Ignas A G; de Mooij, Ernst J W; Albrecht, Simon

    2009-05-28

    Hot Jupiters are a class of extrasolar planet that orbit their parent stars at very short distances. They are expected to be tidally locked, which can lead to a large temperature difference between their daysides and nightsides. Infrared observations of eclipsing systems have yielded dayside temperatures for a number of transiting planets. The day-night contrast of the transiting extrasolar planet HD 189733b was 'mapped' using infrared observations. It is expected that the contrast between the daysides and nightsides of hot Jupiters is much higher at visual wavelengths, shorter than that of the peak emission, and could be further enhanced by reflected stellar light. Here we report the analysis of optical photometric data obtained over 36 planetary orbits of the transiting hot Jupiter CoRoT-1b. The data are consistent with the nightside hemisphere of the planet being entirely black, with the dayside flux dominating the optical phase curve. This means that at optical wavelengths the planet's phase variation is just as we see it for the interior planets in the Solar System. The data allow for only a small fraction of reflected light, corresponding to a geometric albedo of <0.20.

  12. Disentangling planetary and stellar activity features in the CoRoT-2 light curve

    CERN Document Server

    Bruno, G; Almenara, J -M; Barros, S C C; Lanza, A F; Montalto, M; Boisse, I; Santerne, A; Lagrange, A -M; Meunier, N

    2016-01-01

    [Abridged] Context. Stellar activity is an important source of systematic errors and uncertainties in the characterization of exoplanets. Most of the techniques used to correct for this activity focus on an ad hoc data reduction. Aims. We have developed a software for the combined fit of transits and stellar activity features in high-precision long-duration photometry. Our aim is to take advantage of the modelling to derive correct stellar and planetary parameters, even in the case of strong stellar activity. Methods. We use an analytic approach to model the light curve. The code KSint, modified by adding the evolution of active regions, is implemented into our Bayesian modelling package PASTIS. The code is then applied to the light curve of CoRoT-2. The light curve is divided in segments to reduce the number of free parameters needed by the fit. We perform a Markov chain Monte Carlo analysis in two ways. In the first, we perform a global and independent modelling of each segment of the light curve, transits ...

  13. Precise Modeling of the Exoplanet Host Star and CoRoT Main Target HD 52265

    CERN Document Server

    Escobar, M E; Ballot, J; Charpinet, S; Dolez, N; Hui-Bon-Hoa, A; Vauclair, G; Gizon, L; Mathur, S; Quirion, P O; Stahn, T

    2012-01-01

    This paper presents a detailed and precise study of the characteristics of the Exoplanet Host Star and CoRoT main target HD 52265, as derived from asteroseismic studies. The results are compared with previous estimates, with a comprehensive summary and discussion. The basic method is similar to that previously used by the Toulouse group for solar-type stars. Models are computed with various initial chemical compositions and the computed p-mode frequencies are compared with the observed ones. All models include atomic diffusion and the importance of radiative accelerations is discussed. Several tests are used, including the usual frequency combinations and the fits of the \\'echelle diagrams. The possible surface effects are introduced and discussed. Automatic codes are also used to find the best model for this star (SEEK, AMP) and their results are compared with that obtained with the detailed method. We find precise results for the mass, radius and age of this star, as well as its effective temperature and lu...

  14. THE SPACES OF CES(A)RO ALMOST CONVERGENT SEQUENCES AND CORE THEOREMS

    Institute of Scientific and Technical Information of China (English)

    Kuddusi Kayaduman; Mehmet (S)eng(o)nül

    2012-01-01

    As known,the method to obtain a sequence space by using convergence field of an infinite matrix is an old method in the theory of sequence spaces.However,the study of convergence field of an infinite matrix in the space of almost convergent sequences is so new (see [15]).The purpose of this paper is to introduce the new spaces (f) and (fo) consisting of all sequences whose Cesàro transforms of order one are in the spaces f and fo,respectively.Also,in this paper,we show that (f) and (fo) are linearly isomorphic to the spaces f and fo,respectively.The β-and γ-duals of the spaces (f) and (fo) are computed.Furthermore,the classes ((f)∶ μ) and (μ ∶ (f)) of infinite matrices are characterized for any given sequence space μ,and determined the necessary and sufficient conditions on a matrix A to satisfy Bc-core(Ax) (C) K-core(x),K-core(Ax) (C) Bc-core(x),Bc-core(Ax) (C) Bc-core(x),Bc-core(Ax) (C) st-core(x) for all x ∈ l∞.

  15. New RO TFC Membranes by Interfacial Polymerization in n-Dodecane with Various co-Solvents.

    Science.gov (United States)

    Al-Hobaib, Abdullah Sulaiman; Al-Suhybani, Mohammed Sulaiman; Al-Sheetan, Khalid Mohammed; Mousa, Hasan; Shaik, Mohammed Rafi

    2016-04-29

    The objective of this research is to prepare and characterize a new and highly efficient polyamide TFC RO membrane by interfacial polymerization in dodecane solvent mixed with co-solvents. Three co-solvents were tested namely; acetone, ethyl acetate, and diethyl ether of concentration of 0.5, 1, 2, 3, and 5 wt %. The modified membranes were characterized by SEM, EDX, AFM and contact angle techniques. The results showed that addition of co-solvent results in a decrease in the roughness, pore size and thickness of the produced membranes. However, as the concentration of the co-solvent increases the pore size of the membranes gets larger. Among the three co-solvents tested, acetone was found to result in membranes with the largest pore size and contact angle followed by diethyl ether then ethyl acetate. Measured contact angle increases as the concentration of the co-solvent increases reaching a constant value except for ethyl acetate where it was found to drop. Investigating flux and salt rejection by the formulated membranes showed that higher flux was attained when acetone was used as a co-solvent followed by diethyl ether then ethyl acetate. However, the highest salt rejection was achieved with diethyl ether.

  16. New RO TFC Membranes by Interfacial Polymerization in n-Dodecane with Various co-Solvents

    Directory of Open Access Journals (Sweden)

    Abdullah Sulaiman Al-Hobaib

    2016-04-01

    Full Text Available The objective of this research is to prepare and characterize a new and highly efficient polyamide TFC RO membrane by interfacial polymerization in dodecane solvent mixed with co-solvents. Three co-solvents were tested namely; acetone, ethyl acetate, and diethyl ether of concentration of 0.5, 1, 2, 3, and 5 wt %. The modified membranes were characterized by SEM, EDX, AFM and contact angle techniques. The results showed that addition of co-solvent results in a decrease in the roughness, pore size and thickness of the produced membranes. However, as the concentration of the co-solvent increases the pore size of the membranes gets larger. Among the three co-solvents tested, acetone was found to result in membranes with the largest pore size and contact angle followed by diethyl ether then ethyl acetate. Measured contact angle increases as the concentration of the co-solvent increases reaching a constant value except for ethyl acetate where it was found to drop. Investigating flux and salt rejection by the formulated membranes showed that higher flux was attained when acetone was used as a co-solvent followed by diethyl ether then ethyl acetate. However, the highest salt rejection was achieved with diethyl ether.

  17. On k-nearly uniform convex property in generalized Cesàro sequence spaces

    Directory of Open Access Journals (Sweden)

    Suthep Suantai

    2003-10-01

    Full Text Available We define a generalized Cesàro sequence space ces(p, where p=(pk is a bounded sequence of positive real numbers, and consider it equipped with the Luxemburg norm. The main purpose of this paper is to show that ces(p is k-nearly uniform convex (k-NUC for k≥2 when limn→∞infpn>1. Moreover, we also obtain that the Cesàro sequence space cesp(where 1

  18. Development-Induced Displacement in Romania: the Case of Roşia Montană Mining Project

    Directory of Open Access Journals (Sweden)

    Lucian VESALON

    2012-06-01

    Full Text Available This paper proposes a critical discussion of the population displacement processes involved in the Roşia Montană gold-mining project within the theoretical framework of development-induced displacement (DID. We begin with an overview of the geographical context of the rural community, focusing on the social and economic structure of Roşia Montană. After assessing the relocation and resettlement processes, we examine several problems related to the compensation mechanism set up by the mining company. The aim of the research is to highlight the complexity of the consequences of development-induced displacement and the limits of the policies of relocation and resettlement in the area.

  19. Introduction au numéro : Quel modèle de développement ?

    Directory of Open Access Journals (Sweden)

    David Rolland

    2002-10-01

    Full Text Available La thématique de ce deuxième numéro électronique de la Revue Interventions Économiques qui porte sur le modèle québécois de développement, nous interroge, plus largement, sur le modèle ou les politiques qui conviennent au XXIe siècle, "Y a-t-il un modèle québécois ? Défis et perspectives, telle était la question que posaient les organisateurs du colloque de l’année 2000 de l’Association d’Économie Politique. Les articles et documents audiovisuels composant ce numéro sont issus de cette rencon...

  20. The meaning of anti-Ro and anti-La antibodies in primary Sjögren's syndrome.

    Science.gov (United States)

    Hernández-Molina, Gabriela; Leal-Alegre, Gustavo; Michel-Peregrina, Martha

    2011-01-01

    Anti-SSA/Ro and anti-La/SSB are the hallmark antibodies in primary Sjögren's syndrome (pSS), being present in 60-70%. These antibodies have been associated with an earlier disease onset, glandular dysfunction and extraglandular manifestations as well as with other B cells activation markers. In addition an immunogenetic background is important for the autoantibody formation, having a stronger association with HLA-DR2 and HLA-DR3. Anti-Ro/SSA and anti-La/SSB antibodies are useful in the diagnosis of pSS and help to identify more "active" patients, however their association with response to treatment is unclear. Herein we review the evidence regarding the association of these antibodies with HLA background, demographic, clinical, glandular dysfunction, other serologic features and response to treatment in patients with pSS.

  1. Synthesis of [{sup 18}F]RO41-0960, a potent catechol-O-methyltransferase inhibitor, for PET studies

    Energy Technology Data Exchange (ETDEWEB)

    Ding, Y.-S.; Sugano, Y.; Koomen, J.; Aggarwal, D. [Brookhaven National Lab., Upton, NY (United States). Dept. of Chemistry

    1997-04-01

    Ro41-0960 (3,4-dihydroxy-5-nitro-2`-fluorobenzophenone) is a potent, fluorine containing COMT inhibitor. In order to map catechol-O-methyltransferase (COMT) in vivo with PET, no-carrier-added [{sup 18}F]Ro41-0960 was synthesized by the nucleophilic aromatic substitution of [{sup 18}F]fluoride for 2`-nitro on 3,4-dimethoxy-5,2`-dimethoxy-5,2`-dinitrobenzophenone, followed by hydrolysis with HBr. During the course of this study it was found that [{sup 18}F]fluoromethane ([{sup 18}F]CH{sub 3}F) was generated as the side product of nucleophilic aromatic substitution reaction. Various precursors with different hydroxyl protecting groups were then investigated for the effects on this side reaction. (Author).

  2. Tidal evolution of CoRoT massive planets and brown dwarfs and of their host stars

    CERN Document Server

    Ferraz-Mello, Sylvio

    2016-01-01

    Aims: Revisit and improvement of the main results obtained in the study of the tidal evolution of several massive CoRoT planets and brown dwarfs and of the rotation of their host stars. Methods: Simulations of the past and future evolution of the orbital and rotational elements of the systems under the joint action of the tidal torques and the braking due to the stellar wind. Results: Presentation of several paradigms and significant examples of tidal evolution in extrasolar planetary systems. It is shown that the high quality of the photometric and spectrographic observations of the CoRoT objects allow for a precise study of their past and future evolution and to estimate the tidal parameters ruling the dissipation in the systems.

  3. Identification des coefficients de couplage aéroélastique d'une section de pont en soufflerie.

    OpenAIRE

    Andrianne, Thomas

    2005-01-01

    Le domaine de l'aéroélasticité en génie civil s'est largement développé durant les dernières décennies. Béné ciant des travaux antérieurs réalisés en aéronautique, l'aéroélasticité des ouvrages d'art a développé ses caractéristiques propres, centrées essentiellement sur les problèmes d'écoulement autour des corps non pro lés. Ces problèmes peuvent être classés dans les caté- gories suivantes: oscillation due à l'éjection tourbillonnaire, mouvement de galop, ottement et e orts ...

  4. A proposed new diagnostic for Herbig disc geometry. FWHM versus J of CO ro-vibrational lines

    Science.gov (United States)

    Hein Bertelsen, R. P.; Kamp, I.; van der Plas, G.; van den Ancker, M. E.; Waters, L. B. F. M.; Thi, W.-F.; Woitke, P.

    2016-05-01

    Aims: The CO ro-vibrational lines observed from Herbig group II discs are often seen to be broad, while the same lines observed from group I discs are often narrow. This difference is not well understood. In this paper we explore the underlying cause for this difference and provide a pathway for a better understanding of the geometry and structure of the inner discs around Herbig Ae/Be stars. Methods: High spectral resolution infrared spectra of CO ro-vibrational emission from six Herbig Ae/Be candidate stars were taken with the CRyogenic high-resolution InfraRed Echelle Spectrograph (CRIRES) at the Very Large Telescope (VLT). From these spectra, we produce individual and co-added CO ro-vibrational line profiles. We investigate line profile shape differences, and we explore the full width at half maximum (FWHM) variations with J quantum number in the context of disc geometry. Furthermore, we put our new sources into the context of earlier observed sources to study a large sample. For comparison, we also investigate the FWHM variations with J of modelled CO ro-vibrational lines from two typical disc geometries produced with the thermochemical disc modelling code ProDiMo. Results: For our new observations of CO ro-vibrational lines, we find that the FWHM of individual lines are in the range of 10-60 km s-1. We find both narrow and broad single-peaked emission lines, but only Hen 2-80 displays double-peaked emission lines. For HD 250550, the FWHM of the CO lines increases with J value, indicating a radially extended emitting region, while Hen 2-80 shows a constant FWHM versus J behaviour, indicating a narrow emitting region. This qualitatively agrees with the two different modelled disc geometries. Comparing dust and gas inner disc geometries (inferred by the spectral energy distribution (SED) and CO ro-vibrational emission) for the expanded sample of observed Herbig discs, we find no clear correspondence between the SED (spectral energy distribution) groups of the

  5. Endoplasmic reticulum stress causes autophagy and apoptosis leading to cellular redistribution of the autoantigens Ro/Sjögren's syndrome-related antigen A (SSA) and La/SSB in salivary gland epithelial cells.

    Science.gov (United States)

    Katsiougiannis, S; Tenta, R; Skopouli, F N

    2015-08-01

    The aim of this study was to examine the levels of endoplasmic reticulum (ER) stress in minor salivary glands, to investigate the interplay between ER stress-induced autophagy and apoptosis in human salivary gland (HSG) cells and to test the effect of ER stress-induced apoptosis on the cellular redistribution of the two major Sjögren's syndrome (SS) autoantigens Ro/Sjögren's syndrome-related antigen A (SSA) and La/Sjögren's syndrome-related antigen B (SSB). Minor salivary gland biopsies from SS patients and sicca controls were examined by immunohistochemistry for the expression of 78 kDa glucose-regulated protein/binding immunoglobulin protein (GRP78/BiP) as an indicator of unfolded protein response (UPR). HSG cells were treated with thapsigargin (TG) and cell viability, autophagy and apoptosis were assessed. Immunoblot was applied to detect the conversion of LC3I to LC3II and the protein levels of GRP78/BiP and X-box binding protein-1 (XBP-1). Apoptosis was evaluated by a single-stranded DNA enzyme-linked immunosorbent assay (ELISA). Ro/SSA and La/SSB localization was visualized using immunofluorescence. GRP78/BiP was expressed by acinar and ductal epithelial cells in salivary glands of patients and sicca controls. TG treatment induced autophagy, as indicated by enhanced protein expression of LC3II. The protein levels of UPR marker XBP-1 were increased after TG treatment, while GRP78/BiP levels were decreased. TG treatment resulted in induction of HSG apoptosis. Ro/SSA and La/SSB autoantigens were localized predominantly to the cytoplasm in resting cells, while they were redistributed to cell membrane and blebs in the apoptotic cells. In conclusion, ER stress is activated in minor salivary gland epithelial cells from SS patients and controls. ER stress-induced apoptosis in HSG cells leads to cell surface and apoptotic blebs relocalization of Ro/SSA and La/SSB autoantigens.

  6. An abundance study of the red giants in the seismology fields of the CoRoT satellite

    CERN Document Server

    Morel, T; Lagarde, N; Montalban, J; Rainer, M; Poretti, E; Hekker, S; Kallinger, T; Mosser, B; Valentini, M; Carrier, F; Hareter, M; Mantegazza, L; De Ridder, J

    2012-01-01

    A precise characterisation of the red giants in the seismology fields of the CoRoT satellite is a prerequisite for further in-depth seismic modelling. The optical spectra obtained for 19 targets have been used to accurately estimate their fundamental parameters and chemical composition. The extent of internal mixing is also investigated through the abundances of Li, CNO and Na (as well as 12C/13C in a few cases).

  7. Brain perfusion imaging using a Reconstruction-of-Difference (RoD) approach for cone-beam computed tomography

    Science.gov (United States)

    Mow, M.; Zbijewski, W.; Sisniega, A.; Xu, J.; Dang, H.; Stayman, J. W.; Wang, X.; Foos, D. H.; Koliatsos, V.; Aygun, N.; Siewerdsen, J. H.

    2017-03-01

    Purpose: To improve the timely detection and treatment of intracranial hemorrhage or ischemic stroke, recent efforts include the development of cone-beam CT (CBCT) systems for perfusion imaging and new approaches to estimate perfusion parameters despite slow rotation speeds compared to multi-detector CT (MDCT) systems. This work describes development of a brain perfusion CBCT method using a reconstruction of difference (RoD) approach to enable perfusion imaging on a newly developed CBCT head scanner prototype. Methods: A new reconstruction approach using RoD with a penalized-likelihood framework was developed to image the temporal dynamics of vascular enhancement. A digital perfusion simulation was developed to give a realistic representation of brain anatomy, artifacts, noise, scanner characteristics, and hemo-dynamic properties. This simulation includes a digital brain phantom, time-attenuation curves and noise parameters, a novel forward projection method for improved computational efficiency, and perfusion parameter calculation. Results: Our results show the feasibility of estimating perfusion parameters from a set of images reconstructed from slow scans, sparse data sets, and arc length scans as short as 60 degrees. The RoD framework significantly reduces noise and time-varying artifacts from inconsistent projections. Proper regularization and the use of overlapping reconstructed arcs can potentially further decrease bias and increase temporal resolution, respectively. Conclusions: A digital brain perfusion simulation with RoD imaging approach has been developed and supports the feasibility of using a CBCT head scanner for perfusion imaging. Future work will include testing with data acquired using a 3D-printed perfusion phantom currently and translation to preclinical and clinical studies.

  8. An anti-CD45RO immunotoxin eliminates T cells latently infected with HIV-1 in vitro

    OpenAIRE

    McCoig, Cynthia; Dyke, Gregory; Chou, Chin-Sheng; Picker, Louis J.; Ramilo,Octavio; Vitetta, Ellen S.

    1999-01-01

    Despite the success of highly active antiretroviral therapy (HAART) in lowering circulating HIV-1 to undetectable levels in most infected individuals, several studies have documented the presence of a small reservoir of latently infected cells in HAART patients, the majority of which are CD45RO+ memory T cells. We previously have demonstrated that latently infected, replication-competent cells can be generated in vitro after eliminating CD25+ cells with an immunotoxin (IT). The present study ...

  9. Differential effect of benserazide (Ro4-4602) on the concentration of indoleamines in rat pineal and hypothalamus.

    OpenAIRE

    Arendt, J; HO, A.K.; Laud, C.; Marston, A.; Nohria, V.; Smith, J A; Symons, A. M.

    1981-01-01

    1 Low doses (50 and 80 mg/kg) of benserazide (Ro4-4602), an aromatic amino acid decarboxylase inhibitor, markedly reduced 5-hydroxytryptamine and melatonin in the rat pineal gland without affecting hypothalamic 5-hydroxytryptamine. 2 This differential effect shows that inhibition of the pineal gland decarboxylase activity is possible, and confirms that the rat pineal gland is accessible to peripherally acting agents.

  10. ÜRO säästva arengu eesmärgid aastaks 2030 / Meelis Joost

    Index Scriptorium Estoniae

    Joost, Meelis

    2016-01-01

    ÜRO liikmesriikide juhid leppisid 25.‒27. septembril 2015 New Yorgis kokku säästva arengu eesmärkides, mis tuleb saavutada 2030. aastaks. Säästva arengu eesmärgid on kaudselt seotud ka puuetega inimestega. Eesti Puuetega Inimeste Koda huvitab, kuivõrd ligipääsetavus, puuetega inimeste elukvaliteet, kasvav kaasatus ühiskonda ning puuetega inimestele osutatavate sotsiaalteenuste kvaliteet leiab kajastamist säästva arengu tegevuskava elluviimises

  11. TEMPERING AND MECHANICAL PROPERTIES OF RO-Al2O3-SiO2 GLASS%RO-Al2O3-SiO2玻璃的钢化与力学性能

    Institute of Scientific and Technical Information of China (English)

    万德田; 包亦望; 祖成奎; 刘永华; 赵华

    2009-01-01

    Alkali-free RO-Al2O3-SiO2 glass was prepared by the melting method. The effects of residual stress, tempering procedure and sample size on the mechanical properties of RO-Al2O3-SiO2 glass including the elastic modulus, shear modulus, Vickers hardness, flexural strength, and fracture toughness, were investigated. It is revealed that a suitable tempering procedure and residual stress greatly improves the flexural strength and fracture toughness, but has little effect on the other mechanical properties. The flexural strength and fracture toughness are enhanced up to 263 MPa and 2.28 MPa·m1/2, which is about 4 times and 235% of those of original glass, respectively. The effects of symmetrical tempering process and asymmetrical tempering procedure on the mechanical properties were compared in this experiment. It is proven that the asymmetrical tempering procedure may be a good method to enhance the mechanical properties and decrease the failure risk for the case of asymmetrical loads.%采用熔融法制备出了无碱型RO-Al2O3-SiO2玻璃.研究了残余应力、钢化工艺以及样品尺寸对RO-Al2O3-SiO2玻璃的弹性模量、剪切摸量、维氏硬度、弯曲强度和断裂韧性等力学性能的影响.结果表明:合适的钢化工艺和残余应力可以显著提高其弯曲强度和断裂韧性,但对其它力学性能影响较小.经钢化处理后的RO-Al2O3-SiO2玻璃的弯曲强度和断裂韧性分别达到了263 MPa和2.28MPa·m1/2.与没有经钢化处理的玻璃样品相比,分别提高到了4倍和235%.提出了1种新型的钢化工艺--非对称钢化工艺,对于在非对称载荷下服役的玻璃构件来说,非对称钢化工艺有可能在提高玻璃力学性能的同时还可以降低其自爆风险.

  12. The structure of disks around Herbig Ae/Be stars as traced by CO ro-vibrational emission

    CERN Document Server

    van der Plas, G; Waters, L B F M; Dominik, C

    2014-01-01

    We study the emission and absorption of CO ro-vibrational lines in the spectra of intermediate mass pre-main-sequence stars with the aim to determine both the spatial distribution of the CO gas and its physical properties. We also aim to correlate CO emission properties with disk geometry. Using high-resolution spectra containing fundamental and first overtone CO ro-vibrational emission, observed with CRIRES on the VLT, we probe the physical properties of the circumstellar gas by studying its kinematics and excitation conditions. We detect and spectrally resolve CO fundamental ro-vibrational emission in 12 of the 13 stars observed, and in two cases in absorption. Keeping in mind that we studied a limited sample, we find that the physical properties and spatial distribution of the CO gas correlate with disk geometry. Flaring disks show highly excited CO fundamental emission up to v$_u$ = 5, while self-shadowed disks show CO emission that is not as highly excited. Rotational temperatures range between ~250-2000...

  13. A proposed new diagnostic for Herbig disc geometry: FWHM versus J of CO ro-vibrational lines

    CERN Document Server

    Bertelsen, R P Hein; van der Plas, G; Ancker, M E van den; Waters, L B F M; Thi, W -F; Woitke, P

    2016-01-01

    Aims. CO ro-vibrational lines observed from Herbig group II discs are seen to be often broad while the same lines observed from group I discs are often narrow. This difference is not well understood. In this paper we explore the underlying cause for this difference and provide a pathway for a better understanding of the geometry and structure of the inner discs around Herbig Ae/Be stars. Methods. High-spectral-resolution infrared spectra of CO ro-vibrational emission from six Herbig Ae/Be candidate stars were taken with CRIRES (CRyogenic high-resolution InfraRed Echelle Spectrograph) at the VLT (Very Large Telescope). From these spectra, we produce individual and co-added CO ro-vibrational line profiles. We investigate line profile shape differences, and we explore the FWHM (Full Width Half Maximum) variations with J quantum number in the context of disc geometry. Furthermore, we put our new sources into the context of earlier observed sources to study a large sample. For comparison, we also investigate the F...

  14. Atrioventricular Conduction Delay in Fetuses Exposed to Anti-SSA/Ro and Anti-SSB/La Antibodies: A Magnetocardiography Study

    Directory of Open Access Journals (Sweden)

    Annette Wacker-Gußmann

    2012-01-01

    Full Text Available Background. The presence of anti-SSA/Ro and anti-SSB/La antibodies during pregnancy is associated with fetal congenital heart block (CHB, which is primarily diagnosed through fetal echocardiography. Conclusive information about the complete electrophysiology of the fetal cardiac conducting system is still lacking. In addition to echocardiography, fetal magnetocardiography (fMCG can be used. fMCG is the magnetic analogue of the fetal electrocardiogram (ECG. Patients and Methods. Forty-eight pregnant women were enrolled in an observational study; 16 of them tested positive for anti-SSA/Ro and anti-SSB/La antibodies. In addition to routine fetal echocardiography, fMCG was used. Fetal cardiac time intervals (fCTIs were extracted from the magnetic recordings by predefined procedures. ECGs in the neonates of the study group were performed within the first month after delivery. Results. The PQ segment of the fCTI was significantly prolonged in the study group (P=0.007, representing a delay of the electrical impulse in the atrioventricular (AV node. Other fCTIs were within normal range. None of the anti-SSA/Ro and/or anti-SSB/La fetuses progressed to a more advanced heart block during pregnancy or after birth. Conclusion. The study identified a low-risk population within antibody positive mothers, where PQ segment prolongation is associated with a lack of progression of the disease.

  15. Low-amplitude rotational modulation rather than pulsations in the CoRoT B-type supergiant HD 46769

    CERN Document Server

    Aerts, C; Catala, C; Neiner, C; Briquet, M; Castro, N; Schmid, V S; Scardia, M; Rainer, M; Poretti, E; Papics, I; Degroote, P; Bloemen, S; Oestensen, R H; Auvergne, M; Baglin, A; Baudin, F; Michel, E; Samadi, R

    2013-01-01

    {We aim to detect and interpret photometric and spectroscopic variability of the bright CoRoT B-type supergiant target HD\\,46769 ($V=5.79$). We also attempt to detect a magnetic field in the target.} {We analyse a 23-day oversampled CoRoT light curve after detrending, as well as spectroscopic follow-up data, by using standard Fourier analysis and Phase Dispersion Minimization methods. We determine the fundamental parameters of the star, as well as its abundances from the most prominent spectral lines. We perform a Monte Carlo analysis of spectropolarimetric data to obtain an upper limit of the polar magnetic field, assumping a dipole field.} {In the CoRoT data, we detect a dominant period of 4.84\\,d with an amplitude of 87\\,ppm, and some of its (sub-)multiples. Given the shape of the phase-folded light curve and the absence of binary motion, we interpret the dominant variability in terms of rotational modulation, with a rotation period of 9.69\\,d. Subtraction of the rotational modulation signal does not revea...

  16. Structural role of RO and Al{sub 2}O{sub 3} in borate glasses using an ultrasonic technique

    Energy Technology Data Exchange (ETDEWEB)

    Abd El-Moneim, A. [Physics Department, Faculty of Science, Zagazig University, Zagazig (Egypt)]. E-mail: aminabdelmoneim@hotmail.com; Youssof, I.M. [Glass Department, Faculty of Applied Arts, Helwan University, Giza (Egypt); Abd El-Latif, L. [National Institute for Standards, Tersa Street, El-Haram, Giza (Egypt)

    2006-08-15

    The ternary alkaline earth aluminoborate glasses RO-Al{sub 2}O{sub 3}-B{sub 2}O{sub 3}, where R = Mg, Ca, Sr, have been prepared by the normal quenching method. Ultrasonic velocities and attenuation were measured in these glasses using the pulse-echo technique to explore the structural role of RO and Al{sub 2}O{sub 3} in these glasses. From the measured densities and velocities, various parameters such as elastic moduli, microhardness and Poisson's ratio have been determined. Results obtained are discussed in terms of the field strength of the interstitial cation, molar ratio (Al{sub 2}O{sub 3}/RO), fraction of four coordinated boron atoms, number of network bonds per unit volume, average cross-link density and fractal bond connectivity of the network. It was found that the network connectivity of these glasses increases in the order Mg > Ca > Sr. Makishima and Mackenzie theory has been applied to correlate the experimental and theoretical data and good correlation was observed.

  17. CoRoT 105906206: a short-period and totally eclipsing binary with a Delta Scuti type pulsator

    CERN Document Server

    da Silva, Ronaldo; Gandolfi, Davide; Lehmann, Holger; Hatzes, Artie P

    2014-01-01

    Eclipsing binary systems with pulsating components allow the determination of several physical parameters of the stars, such as mass and radius, that, when combined with the pulsation properties, can be used to constrain the modeling of stellar interiors and evolution. Hereby, we present the results of the study of CoRoT 105906206, an eclipsing binary system with a pulsating component located in the CoRoT LRc02 field. The analysis of the CoRoT light curve was complemented by high-resolution spectra from the Sandiford at McDonald Observatory and FEROS at ESO spectrographs, which revealed a double-lined spectroscopic binary. We used an iterative procedure to separate the pulsation-induced photometric variations from the eclipse signals. First, a Fourier analysis was used to identify the significant frequencies and amplitudes due to pulsations. Second, after removing the contribution of the pulsations from the light curve we applied the PIKAIA genetic-algorithm approach to derive the best parameters that describ...

  18. Future Energy Benchmark for Desalination: is it Better to have a Power (electricity) Plant with ro or Med/msf?

    Science.gov (United States)

    Shahzad, Muhammad Wakil; Ng, Kim Choon; Thu, Kyaw

    2016-06-01

    Power and desalination cogeneration plants are common in many water scared courtiers. Designers and planners for cogeneration face tough challenges in deciding the options:- Is it better to operate a power plant (PP) with the reverse osmosis (i.e., PP+RO) or the thermally-driven multi-effect distillation/multi-stage flashed (PP+MED/MSF) methods. From literature, the RO methods are known to be energy efficient whilst the MED/MSF are known to have excellent thermodynamic synergies as only low pressure and temperature steam are used. Not with-standing the challenges of severe feed seawater of the Gulf, such as the frequent harmful algae blooms (HABs) and high silt contents, this presentation presents a quantitative analyses using the exergy and energetic approaches in evaluating the performances of a real cogeneration plant that was recently proposed in the eastern part of Saudi Arabia. We demonstrate that the process choice of PP+RO versus PP+MED depends on the inherent efficiencies of individual process method which is closely related to innovative process design. In this connection, a method of primary fuel cost apportionment for a co-generation plant with a MED desalination is presented. We show that an energy approach, that captures the quality of expanding steam, is a better method over the conventional work output (energetic) and the energy method seems to be over-penalizing a thermally-driven MED by as much as 22% in the operating cost of water.

  19. From CoRoT 102899501 to the Sun. A time evolution model of chromospheric activity on the main sequence

    CERN Document Server

    Gondoin, P; Fridlund, M; Frasca, A; Guenther, E W; Hatzes, A; Deeg, H J; Parviainen, H; Eigmueller, P; Deleuil, M

    2012-01-01

    Using a model based on the rotational modulation of the visibility of active regions, we analyse the high-accuracy CoRoT lightcurve of the active young star CoRoT102899501. Spectroscopic follow-up observations are used to derive its fundamental parameters. We compare its chromospheric activity level with a model of chrosmospheric activity evolution established by combining relationships between the R'HK index and the Rossby number with a recent model of stellar rotation evolution on the main sequence. We measure the spot coverage of the stellar surface as a function of time, and find evidence for a tentative increase from 5-14% at the beginning of the observing run to 13-29% 35 days later. A high level of magnetic activity on CoRoT102899501 is corroborated by a strong emission in the Balmer and Ca II HK lines (logR'HK ~ -4). The starspots used as tracers of the star rotation constrain the rotation period to 1.625+/-0.002 days and do not show evidence for differential rotation. The effective temperature (Teff=...

  20. The CoRoT-GES Collaboration. Improving Red Giants spectroscopic surface gravity and abundances with asteroseismology

    CERN Document Server

    Valentini, M; Miglio, A; Montalbán, J; Rodrigues, T; Mosser, B; Anders, F

    2016-01-01

    Nowadays large spectroscopic surveys, like the Gaia-ESO Survey (GES), provide unique stellar databases for better investigating the formation and evolution of our Galaxy. Great attention must be paid to the accuracy of the basic stellar properties derived: large uncertainties in stellar parameters lead to large uncertainties in abundances, distances and ages. Asteroseismology has a key role in this context: when seismic information is combined with information derived from spectroscopic analysis, highly precise constraints on distances, masses, extinction and ages of Red Giants can be obtained. In the light of this promising joint-action, we started the CoRoT-GES collaboration. We present a set of 1,111 CoRoT stars, observed by GES from December 2011 to July 2014, these stars belong to the CoRoT field LRc01, pointing at the inner Galactic Disk. Among these stars, 534 have reliable global seismic parameters. By combining seismic informations and spectroscopy, we derived precise stellar parameters, ages, kinema...

  1. The variability of the CoRoT target HD171834: gamma Dor pulsations and/or activity?

    CERN Document Server

    Uytterhoeven, K; Baglin, A; Rainer, M; Poretti, E; Amado, P; Chapellier, E; Mantegazza, L; Pollard, K; Suarez, J C; Kilmartin, P M; Sato, K H; Garcia, R A; Auvergne, M; Michel, E; Samadi, R; Catala, C; Baudin, F

    2011-01-01

    We present the preliminary results of a frequency and line-profile analysis of the CoRoT gamma Dor candidate HD171834. The data consist of 149 days of CoRoT light curves and a ground-based dataset of more than 1400 high-resolution spectra, obtained with six different instruments. Low-amplitude frequencies between 0 and 5 c/d, dominated by a frequency near 0.96 c/d and several of its harmonics, are detected. These findings suggest that HD171834 is not a mere gamma Dor pulsator and that stellar activity plays an important role in its variable behaviour. Based on CoRoT space data and on ground-based observations with ESO Telescopes at the La Silla Observatory under the ESO Large Programmes ESO LP 178.D-0361 and ESO LP 182.D-0356 (FEROS/2.2m and HARPS/3.6m), and data collected with FOCES/2.2m at the Centro Astronomico Hispano Aleman at Calar Alto, SOPHIE/1.93m at Observatoire de Haute Provence, FIES/NOT at Observatorio del Roque de los Muchachos, and HERCULES/1.0m at Mount John University Observatory.

  2. MIARMA: An information preserving method for filling gaps in time series. Application to CoRoT light curves

    CERN Document Server

    Pascual-Granado, J; Suárez, J C

    2014-01-01

    The method here presented intends to minimize the effect of the gaps in the power spectra by gap-filling preserving the original information, that is, in the case of asteroseismology, the stellar oscillation frequency content. We make use of a forward-backward predictor based on autoregressive moving average modelling (ARMA) in the time domain. The method MIARMA is particularly suitable for replacing invalid data such as those present in the light curves of the CoRoT satellite due to the pass through the South Atlantic Anomaly, and eventually for the data gathered by the NASA planet hunter Kepler. We select a sample of stars from the ultra-precise photometry collected by the asteroseismic camera on board the CoRoT satellite: the {\\delta} Scuti star HD 174966, showing periodic variations of the same order as the CoRoT observational window, the Be star HD 51193, showing longer time variations, and the solar-like HD 49933, with rapid time variations. We showed that in some cases linear interpolations are less re...

  3. CoRoT-22 b: a validated 4.9 RE exoplanet in 10-day orbit

    CERN Document Server

    Moutou, C; Diaz, R F; Alonso, R; Deleuil, M; Guenther, E; Pasternacki, T; Aigrain, S; Baglin, A; Barge, P; Bonomo, A; Borde, P; Bouchy, F; Cabrera, J; Carpano, S; Cochran, W; Csizmadia, Sz; Deeg, H; Dvorak, R; Endl, M; Erikson, A; Ferraz-Mello, S; Gandolfi, D; Guillot, T; Artzes, A; Hebrard, G; Lovis, C; Lammer, H; McQueen, P; Mazeh, T; Ofir, A; Ollivier, M; Paetzold, M; Rauer, H; Rouan, D; Santerne, A; Schneider, J; Tingley, B; Wuchterl, G

    2014-01-01

    The CoRoT satellite has provided high-precision photometric light curves for more than 163,000 stars and found several hundreds of transiting systems compatible with a planetary scenario. If ground-based velocimetric observations are the best way to identify the actual planets among many possible configurations of eclipsing binary systems, recent transit surveys have shown that it is not always within reach of the radial-velocity detection limits. In this paper, we present a transiting exoplanet candidate discovered by CoRoT whose nature cannot be established from ground-based observations, and where extensive analyses are used to validate the planet scenario. They are based on observing constraints from radial-velocity spectroscopy, adaptive optics imaging and the CoRoT transit shape, as well as from priors on stellar populations, planet and multiple stellar systems frequency. We use the fully Bayesian approach developed in the PASTIS analysis software, and conclude that the planet scenario is at least 1400 ...

  4. Future Energy Benchmark for Desalination: Is it Better to have a Power (Electricity) Plant With RO or MED/MSF?

    KAUST Repository

    Shahzad, Muhammad Wakil

    2016-06-23

    Power and desalination cogeneration plants are common in many water scared courtiers. Designers and planners for cogeneration face tough challenges in deciding the options:- Is it better to operate a power plant (PP) with the reverse osmosis (i.e., PP+RO) or the thermally-driven multi-effect distillation/multi-stage flashed ( PP+MED/MSF) methods. From literature, the RO methods are known to be energy efficient whilst the MED/MSF are known to have excellent thermodynamic synergies as only low pressure and temperature steam are used. Not with-standing the challenges of severe feed seawater of the Gulf, such as the frequent harmful algae blooms (HABs) and high silt contents, this presentation presents a quantitative analyses using the exergy and energetic approaches in evaluating the performances of a real cogeneration plant that was recently proposed in the eastern part of Saudi Arabia. We demonstrate that the process choice of PP+RO versus PP+MED depends on the inherent efficiencies of individual process method which is closely related to innovative process design. In this connection, a method of primary fuel cost apportionment for a co-generation plant with a MED desalination is presented. We show that an energy approach, that captures the quality of expanding steam, is a better method over the conventional work output (energetic) and the energy method seems to be over-penalizing a thermally-driven MED by as much as 22% in the operating cost of water.

  5. Corticosteroid treatment normalizes QTc prolongation and improves heart block in an elderly patient with anti-Ro-positive systemic lupus erythematosus.

    Science.gov (United States)

    Saribayev, Maksat; Tufan, Fatih; Oz, Fahrettin; Erer, Burak; Ozpolat, Tahsin; Ozturk, Gulistan Bahat; Akin, Sibel; Saka, Bulent; Erten, Nilgun; Tascioglu, Cemil; Karan, Akif

    2014-06-01

    Systemic lupus erythematosus (SLE) is a multisystemic disease which potentially involves various organs including the skin, joints, kidneys, liver, hematopoetic system, and serous membranes. It is rarely seen in elderly males. The most common cardiovascular involvement type is pericarditis. Anti-Ro antibodies may be associated with neonatal lupus which causes heart blocks. Recent literature indicates that anti-Ro antibodies may be associated with various rhythm and conduction disturbances in the adulthood. The most common finding associated with anti-Ro antibodies is prolonged corrected QT (QTc) interval. Herein, we present an elderly male patient with anti-Ro-positive SLE associated with prolonged QTc interval and AV blocks that significantly improved after corticosteroid treatment.

  6. RoF在无线接入领域的应用及发展趋势%Application and development of wireless access on radio over fiber technology

    Institute of Scientific and Technical Information of China (English)

    杨洋

    2012-01-01

    The convergence of optical and wireless networking is a promising development for fixture access network architecture. In this paper, composition, and key technic in design and implementation of the radio over fiber are mainly introduced, and its advantages and military issues can be solved is analysed in detail, The wide applications of RoF technologies for network convergence are presented in the end.%RoF技术是未来无线接入网的一大发展方向,简要介绍了RoF技术的构成、实现方式以及实用的关键技术,并详细分析了它的优势,展现了RoF技术的广阔应用前景及发展趋势.

  7. Rahvusvahelise terrorismi defineerimine ÜRO raames : [bakalaureusetöö] / Tuuli Pärnsalu ; Tartu Ülikool, õigusteaduskond ; juhendaja: Kristi Land

    Index Scriptorium Estoniae

    Pärnsalu, Tuuli

    2003-01-01

    Rahvusvahelise terrorismi defineerimise tähtsus, inimõiguste kaitse, riikidevaheline koostöö terrorismi definitsiooni otsingutel, definitsiooni elemendid, riigiterrorismi kontseptsioon, riikidevahelise terrorismiga seotud vaidluste lahendamine ÜRO raames

  8. The anxiogenic action of FG 7142 in the social interaction test is reversed by chlordiazepoxide and Ro 15-1788 but not by CGS 8216.

    Science.gov (United States)

    File, S E; Pellow, S

    1984-10-01

    The effects of FG 7142 were examined in the social interaction test, alone and in combination with chlordiazepoxide, Ro 15-1788 and CGS 8216. The anxiogenic action of FG 7142 (5 mg/kg) was reversed by chlordiazepoxide (5 mg/kg) and by Ro 15-1788 (10 mg/kg), but not by CGS 8216 (10 mg/kg). The profile of FG 7142 in this test and the pattern of its interactions with other compounds is similar to that of beta-CCE, but can be distinguished from that of Ro 15-1788 and CGS 8216. It is concluded that FG 7142, Ro 15-1788 and CGS 8216 may act via different sites to produce their anxiogenic effects.

  9. The development of a quantitative assay for the detection of anti-Ro/SS-A and anti-LA/SS-B autoantibodies using purified recombinant proteins.

    Science.gov (United States)

    Veldhoven, C H; Meilof, J F; Huisman, J G; Smeenk, R J

    1992-07-01

    A characteristic of patients with autoimmune diseases such as Sjögren's syndrome and systemic lupus erythematosus is the presence of anti-Ro/SS-A and anti-La/SS-B autoantibodies in their circulation. In order to investigate specific autoantibody levels in the sera of these patients quantitative assays for the detection of both anti-Ro/SS-A and anti-La/SS-B reactivity were developed. Ro/SS-A (60 kDa) and La-SS-B (50 kDa) cDNAs were cloned and expressed in E. coli as non-fusion proteins. These were purified to homogeneity using two different purification protocols. With these recombinant antigens, specific enzyme-linked immunosorbent assays (ELISAs) were developed. 40 sera positive for anti-Ro/SS-A autoantibodies in counterimmunoelectrophoresis (CIE) were tested in both the Ro/SS-A and La/SS-B ELISA. Activity values reproducibly ranged from 1536 to 120,000 U in the Ro/SS-A ELISA and from 763 to 2,500,000 U in the La/SS-B ELISA. The suitability of these ELISAs as screening assays was further investigated by testing 200 sera sent to our laboratory for routine detection of autoantibodies to extractable nuclear antigen (ENA: anti-Sm, anti-RNP, anti-Ro/SS-A and anti-La/SS-B). Both ELISAs showed a high sensitivity and specificity (Ro/SS-A ELISA 85% and 94%, La/SS-B ELISA 100% and 98% respectively), when compared to the standard assays, the RNA-precipitation assay and the HeLa immunoblotting test. From these data we conclude that a quantitative analysis of both anti-Ro/SS-A and anti-La/SS-B autoantibodies is now possible using purified recombinant non-fusion proteins. For screening purposes the La/SS-B ELISA showed a great improvement in sensitivity for the detection of anti-La/SS-B activity in comparison to the La/SS-B CIE, while the Ro/SS-A ELISA almost equalled the performance of the Ro/SS-A CIE.

  10. Ro 04-6790-induced cognitive enhancement: no effect in trace conditioning and novel object recognition procedures in adult male Wistar rats.

    Science.gov (United States)

    Thur, K E; Nelson, A J D; Cassaday, H J

    2014-12-01

    The evidence for cognitively enhancing effects of 5-hydroxytryptamine6 (5-HT6) receptor antagonists such as Ro 04-6790 is inconsistent and seems to depend on the behavioral test variant in use. Trace conditioning holds promise as a behavioral assay for hippocampus-dependent working memory function. Accordingly, Experiment 1 assessed the effect of Ro 04-6790 (5 and 10mg/kg i.p.) on associating a noise conditioned stimulus paired with foot shock (unconditioned stimulus) at a 3 or 30s trace interval in adult male Wistar rats. Contextual conditioning was measured as suppression to the contextual cues provided by the experimental chambers and as suppression to a temporally extended light background stimulus which provided an experimental context. Experiment 2 assessed the effect of Ro 04-6790 (5 and 10mg/kg i.p.) on recognition memory as tested by the exploration of novel relative to familiar objects in an open arena. In Experiment 1, Ro 04-6790 (5 and 10mg/kg) was without effect on trace and contextual conditioning. In Experiment 2, there was no indication of the expected improvement under Ro 04-6790 at the same doses previously found to enhance recognition memory as measured in tests of novel object exploration. Thus, there was no evidence that treatment with the 5-HT6 receptor antagonist Ro 04-6790 acted as a cognitive enhancer in either trace conditioning or object recognition procedures. We cannot exclude the possibility that the experimental procedures used in the present study would have been sensitive to the cognitive enhancing effects of Ro 04-6790 in a different dose range, behavioral test variant, or in a different strain of rat. Nonetheless the drug treatment was not ineffective in that object exploration was reduced under 10mg/kg Ro 04-6790.

  11. Impacts of uncertainty in AVOC emissions on the summer RO x budget and ozone production rate in the three most rapidly-developing economic growth regions of China

    Science.gov (United States)

    Wang, Feng; An, Junling; Li, Ying; Tang, Yujia; Lin, Jian; Qu, Yu; Chen, Yong; Zhang, Bing; Zhai, Jing

    2014-11-01

    High levels of uncertainty in non-methane volatile organic compound (NMVOC) emissions in China could lead to significant variation in the budget of the sum of hydroxyl (OH) and peroxy (HO2, RO2) radicals (RO x = OH + HO2 + RO2) and the ozone production rate [P(O3)], but few studies have investigated this possibility, particularly with three-dimensional air quality models. We added diagnostic variables into the WRF-Chem model to assess the impact of the uncertainty in anthropogenic NMVOC (AVOC) emissions on the RO x budget and P(O3) in the Beijing-Tianjin-Hebei region, Yangtze River Delta, and Pearl River Delta of China. The WRF-Chem simulations were compared with satellite and ground observations, and previous observation-based model studies. Results indicated that 68% increases (decreases) in AVOC emissions produced 4%-280% increases (2%-80% decreases) in the concentrations of OH, HO2, and RO2 in the three regions, and resulted in 35%-48% enhancements (26%-39% reductions) in the primary RO x production and ˜ 65% decreases (68%-73% increases) of the P(O3) in Beijing, Shanghai, and Guangzhou. For the three cities, the two largest contributors to the RO x production rate were the reaction of O1D + H2O and photolysis of HCHO, ALD2, and others; the reaction of OH + NO2 (71%-85%) was the major RO x sink; and the major contributor to P(O3) was the reaction of HO2 + NO (˜ 65%). Our results showed that AVOC emissions in 2006 from Zhang et al. (2009) have been underestimated by ˜ 68% in suburban areas and by > 68% in urban areas, implying that daily and hourly concentrations of secondary organic aerosols and inorganic aerosols could be substantially underestimated, and cloud condensation nuclei could be underestimated, whereas local and regional radiation was overestimated.

  12. Ro 15-1788-C/sup 11/ and flunitrazepam-C/sup 11/; two coordinates for the study of benzodiazepines binding sites by positron emission tomography

    Energy Technology Data Exchange (ETDEWEB)

    Maziere, M.; Prenant, C.; Sastre, J.; Crouzel, M.; Comar, D. (C.E.A., Orsay (France)); Hantraye, P.; Kaisima, M.; Guibert, B.; Naquet, R. (C.N.R.S., Gif-sur-Yvette (France))

    1983-05-16

    In vivo binding of a benzodiazepine (flunitrazepam-C/sup 11/) and a benzodiazepine antagonist (Ro 15-1788-C/sup 11/) were studied with positron emission tomography. Advantages and disadvantages of each drug for studying specific in vivo binding sites are presented. The results obtained indicate that Ro 15-1788-C/sup 11/ is a better in vivo radiocoordinat than flunitrazepam-C/sup 11/.

  13. The RoPE Score and Right-to-Left Shunt Severity by Transcranial Doppler in the CODICIA Study

    Science.gov (United States)

    Wessler, Benjamin S.; Kent, David M.; Thaler, David E.; Ruthazer, Robin; Lutz, Jennifer S.; Serena, Joaquín

    2015-01-01

    Background For patients with cryptogenic stroke (CS) and patent foramen ovale (PFO), it is unknown whether the magnitude of right-to-left shunt (RLSh) measured by contrast transcranial Doppler (c-TCD) is correlated with the likelihood an identified PFO is related to CS as determined by the Risk of Paradoxical Embolism (RoPE) score. Additionally, for patients with CS, it is unknown whether PFO assessment by c-TCD is more sensitive for identifying RLSh compared with transesophageal echocardiography (TEE). Our aim was to determine the significance of RLSh grade by c-TCD in patients with PFO and CS. Methods We evaluated patients with CS who had RLSh quantified by c-TCD in The Multicenter Study into RLSh in Cryptogenic Stroke (CODICIA) to determine whether there is an association between c-TCD shunt grade and the RoPE Score. For patients who underwent c-TCD and TEE, we determined whether there is agreement in identifying and grading RLSh between these two modalities. Results The RoPE score predicted the presence versus the absence of RLSh documented by contrast transcranial Doppler (c-statistic = 0.66). For patients with documented RLSh by c-TCD, shunt severity was correlated with increasing RoPE score (rank correlation (r) = 0.15, p = 0.01). Among 293 patients who had both c-TCD and TEE performed, c-TCD was more sensitive (98.7%) for detecting RLSh. Of the 97 patients with no PFO identified on TEE, 28 (29%) had a large amount of RLSh seen on c-TCD. Conclusions For patients with CS, severity of RLSh by c-TCD is positively correlated with the RoPE score, indicating this technique for shunt grading identifies patients more likely to have pathogenic rather than incidental PFOs. C-TCD is also more sensitive in detecting RLSh than TEE. These findings suggest an important role for c-TCD in the evaluation of PFO in the setting of CS. PMID:26184495

  14. Identifying the upper atmosphere structure of the inflated hot sub-Neptune CoRoT-24b

    Science.gov (United States)

    Juvan, Ines; Lammer, Helmut; Erkaev, Nikolai V.; Fossati, Luca; Cubillos, Patricio E.; Guenther, Eike; Odert, Petra; Kislyakova, Kristina G.; Lendl, Monika

    2016-04-01

    The CoRoT satellite mission discovered two Neptune-type planets, CoRoT-24b and CoRoT-24c, with observed transit radii of ≈3.7REarth and ≈4.9REarth and masses of ≤5.7MEarth and ≈28MEarth, respectively. From the deduced low mean densities it can be expected that their planetary cores are most likely surrounded by H2 dominated envelopes. While having very similar radii, the outer planet CoRoT-24c is at least 4.9 times more massive than its neighbour, indicating that their atmospheres can be fundamentally different. Therefore, we have investigated the upper atmosphere structure and escape rates of these two planets. We applied a hydrodynamic upper atmosphere model including heating by absorption of stellar extreme ultraviolet and X-ray (XUV) radiation, under the assumption that the observed transit radius RT is produced by Rayleigh scattering and H2-H2 collision absorption in a pure hydrogen atmosphere. This corresponds to a pressure level near 1 bar. We find an unsustainably high hydrodynamic escape rate of 1.6 × 1011 g/s for the atmosphere of CoRoT-24b. If real, such high atmospheric escape would lead to substantial mass loss from the planetary atmosphere, shrinking it to ≈2.2REarth within ≈4 Myr, which is inconsistent with the old age of the system. The solution to this discrepancy is that the observed transit radius RT must be 30-60% larger than the actual planetary radius at the 1 bar pressure level. We suggest that the observed transit radius RT is produced by absorption through scattering processes due to high altitude clouds or hazes. The Kepler satellite has discovered similar close-in low-density Neptune-type planets. We propose that it is very likely that the observed transit radii for the vast majority of these planets also differ from their actual planetary radii at the 1 bar pressure level. This would introduce a systematic bias in the measured radii and has dramatic implications in the determination of the mass-radius relation and for planet

  15. Influence of changes in humidity on dry temperature in GPS RO climatologies

    Directory of Open Access Journals (Sweden)

    J. Danzer

    2014-09-01

    Full Text Available Radio occultation (RO data are increasingly used in climate research. Accurate phase (change measurements of Global Positioning System (GPS signals are the basis for the retrieval of near-vertical profiles of bending angle, microwave refractivity, density, pressure, and temperature. If temperature is calculated from observed refractivity with the assumption that water vapor is zero, the product is called "dry temperature", which is commonly used to study earth's atmosphere, e.g., when analyzing temperature trends due to global warming. Dry temperature is a useful quantity, since it does not need additional background information in its retrieval. However, it can only be safely used as proxy for physical temperature, where moisture is negligible. The altitude region above which water vapor does not play a dominant role anymore, depends primarily on latitude and season. In this study we first investigated the influence of water vapor on dry temperature RO profiles. Hence, we analyzed the maximum altitude down to which monthly mean dry temperature profiles can be regarded as being equivalent to physical temperature. This was done by examining dry temperature to physical temperature differences of monthly mean analysis fields from the European Centre for Medium-Range Weather Forecasts (ECMWF, studied from 2006 until 2010. We introduced cutoff criteria, where maximum temperature differences of −0.1, −0.05, and −0.02 K were allowed (dry temperature is always lower than physical temperature, and computed the corresponding altitudes. As an example, a temperature difference of −0.05 K in the tropics was found at an altitude of about 14 km, while at higher northern latitudes in winter it was found at an altitude of about 9–10 km, in summer at about 11 km. Furthermore, regarding climate change, we expect an increase of absolute humidity in the atmosphere. This possible trend in water vapor could yield a wrongly interpreted dry temperature trend

  16. GPS RO sensing of Boundary Layer Height within Southern Ocean Cyclones

    Science.gov (United States)

    Schuddeboom, Alex; McDonald, Adrian; Katurji, Marwan; Morgenstern, Olaf; Harvey, Mike

    2016-04-01

    The COSMIC constellation of GPS RO satellites has been used extensively over the previous few years to generate climatologies of boundary layer height (BLH). These satellites use high precision clocks to measure the time it takes for a signal to be transmitted through the atmosphere. From the time measurements, the angle of refraction of the signal can be calculated and then used in turn to calculate atmospheric refractivity. Boundary layer heights can then be determined by identifying sharp gradients in the refractivity profile. The results of this approach have been compared with radiosonde data and show a high level of agreement. By using this technique, we also generated a BLH climatology which was then used to analyse how the height of the boundary layer varies within the specific meteorological context of Southern Ocean cyclones. Analysis of the BLH behaviour over cyclones was primarily based upon generating cyclone composites. This is done by averaging together measurements in a cyclone relative framework to generate a representative cyclone. This technique allows a direct examination of the mean state, however it is also valuable for further analysis such as splitting the composite into regions and analysing the distribution of values over each of these sub-regions. We also investigated the relationship between boundary layer height and surface variables. There is a particularly strong negative relationship between sea ice concentration and boundary layer height. The reasons for this phenomenon are not entirely clear but appear to be at least partially related to changes in the surface sensible heat flux. The effects of other surface variables such as air temperature, sea surface temperature and wind speeds were relatively minor.

  17. Validation of MIPAS IMK/IAA V5R_O3_224 ozone profiles

    Directory of Open Access Journals (Sweden)

    A. Laeng

    2014-11-01

    Full Text Available We present the results of an extensive validation program of the most recent version of ozone vertical profiles retrieved with the IMK/IAA (Institute for Meteorology and Climate Research/Instituto de Astrofísica de Andalucía MIPAS (Michelson Interferometer for Passive Atmospheric Sounding research level 2 processor from version 5 spectral level 1 data. The time period covered corresponds to the reduced spectral resolution period of the MIPAS instrument, i.e., January 2005–April 2012. The comparison with satellite instruments includes all post-2005 satellite limb and occultation sensors that have measured the vertical profiles of tropospheric and stratospheric ozone: ACE-FTS, GOMOS, HALOE, HIRDLS, MLS, OSIRIS, POAM, SAGE II, SCIAMACHY, SMILES, and SMR. In addition, balloon-borne MkIV solar occultation measurements and ground-based Umkehr measurements have been included, as well as two nadir sensors: IASI and SBUV. For each reference data set, bias determination and precision assessment are performed. Better agreement with reference instruments than for the previous data version, V5R_O3_220 (Laeng et al., 2014, is found: the known high bias around the ozone vmr (volume mixing ratio peak is significantly reduced and the vertical resolution at 35 km has been improved. The agreement with limb and solar occultation reference instruments that have a known small bias vs. ozonesondes is within 7% in the lower and middle stratosphere and 5% in the upper troposphere. Around the ozone vmr peak, the agreement with most of the satellite reference instruments is within 5%; this bias is as low as 3% for ACE-FTS, MLS, OSIRIS, POAM and SBUV.

  18. Observations of Equatorial Kelvin Wave Modes in FORMOSAT-3/COSMIC GPS RO Temperature Profiles

    Directory of Open Access Journals (Sweden)

    Potula Sree Brahmanandam

    2010-01-01

    Full Text Available In this study, we analyze FORMOSAT-3/COSMIC (F3/C GPS radio occultation (RO derived temperature components for the period September 2006 to February 2008. Results show the presence of slow Kelvin waves (wave period > 10 days with higher zonal wavenumbers (either one or two in the upper troposphere and lower stratosphere (UTLS. The vertical wavelengths of these waves are found to be in the range of 5 - 12 km. The predominant Kelvin waves observed in the temperature fluctuations are in the altitude range between 15 and 28 km and centered on the tropical tropopause. The downward phase progression of these waves suggests that the derived waves are propagating upward, with the source region located at lower altitudes possibly due to tropical convective heating. The zonal winds retrieved using radiosonde observations over Singapore (1¢XN, 104¢XE during this period show a periodicity of ~24 - 26 months in the stratosphere, and quasi-biennial oscillation (QBO characteristics with eastward zonal winds from March 2006 to May 2007 and westward winds from June 2007 to July 2008 respectively. Our results further show that the Kelvin wave characteristics are enhanced during the westward phase of QBO and diminish during the eastward phase, in line with the previous reported results. Furthermore, an examination of outgoing longwave radiation (OLR data shows that deep convection activity is developed episodically over the Indonesian archipelago during the observation period, thereby indicating that the Kelvin wave events observed in temperature fluctuations are either driven by convective activity (convectively coupled waves or by a broad spectrum of convective variability (free waves over the Indonesian region.

  19. On the Lowest Ro-Vibrational States of Protonated Methane: Experiment and Analytical Model

    Science.gov (United States)

    Schmiedt, Hanno; Jensen, Per; Asvany, Oskar; Schlemmer, Stephan

    2016-06-01

    Protonated methane, CH_5^+, is the prototype of an extremely floppy molecule. To the best of our knowledge all barriers are surmountable in the rovibrational ground state; the large amount of zero-point vibrational energy leads to large amplitude motions for many degrees of freedom. Low resolution but broad band vibrational spectroscopy [1] revealed an extremely wide range of C-H stretching vibrations. Comparison with theoretical IR spectra supported the structural motif of a CH_3 tripod and an H_2 moiety, bound to the central carbon atom by a 3c2e bond. In a more dynamic picture the five protons surround the central carbon atom without significant restrictions on the H-C-H bending or H_n-C torsional motions. The large-amplitude internal motions preclude a simple theoretical description of the type possible for more conventional molecules, such as the related spherical-top methane molecule. Recent high-resolution ro-vibrational spectra obtained in cold ion trap experiments [2] show that the observed CH_5^+ transitions belong to a very well-defined energy level scheme describing the lowest rotational and vibrational states of this enigmatic molecule. Here we analyse the experimental ground state combination differences and associate them with the motional states of CH_5^+ allowed by Fermi-Dirac statistics. A model Hamiltonian for unrestricted internal rotations in CH_5^+ yields a simple analytical expression for the energy eigenvalues, expressed in terms of new quantum numbers describing the free internal rotation. These results are compared to the experimental combination differences and the validity of the model will be discussed together with the underlying assumptions. [1] O. Asvany, P. Kumar, I. Hegemann, B. Redlich, S. Schlemmer and D. Marx, Science 309, (2005) 1219-1222 [2] O. Asvany, K.M.T. Yamada, S. Brünken, A. Potapov, S. Schlemmer, Science 347 (2015) 1346-1349

  20. Impact of Mining Activity upon Environment in Roşia Montană

    Directory of Open Access Journals (Sweden)

    SIGISMUND DUMA

    2008-01-01

    Full Text Available Roşia Montană is the greatest gold ore in Romania and one of the greatest in Europe, and its exploitation has been carried out since Antiquity up to nowadays. If the traditional extraction and processing technologies had a minimal impact upon environment, the ones adopted in modern times have affected all the components of the natural environment. In the perspective of capitalizing the gold ore through the programme elaborated by the Canadian company, Gold Corporation, the zonal geographical space will be degraded up to the level of industrial dessert over an area of 100 km2 and in case of damage, the affected area can extend enormously. The environmental problems are related both to the specific nature of such an industrial activity and, especially, to the use of enormous quantities of sodium cyanide directly on the preparation flux from the industrial plant. Few such cases are known worldwide, in several economically less developed countries. Usually, cyanides are used for treating the gold concentrations, operation done in conditions of maximum security, in closed spaces, situated in isolated zones and the neutralization (detoxification of cyanides is done in situ. The treatment of cyanides in open spaces has always generated environmental problems. Moreover, none of the cyanide treatment technologies eliminates entirely their toxic effect (less toxic chemical products are obtained. In order to avoid the production of an environmental disaster and to preserve the local patrimony values (in this place there lies the richest mining archeological site in Europe, we elaborated several recommendations we consider feasible as they allow both the capitalization of ore, which is a socio-economic necessity of the area, and the ecological reconstruction of the affected geographical space.