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Sample records for host-guest system achieves

  1. Switchable host-guest systems on surfaces.

    Science.gov (United States)

    Yang, Ying-Wei; Sun, Yu-Long; Song, Nan

    2014-07-15

    CONSPECTUS: For device miniaturization, nanotechnology follows either the "top-down" approach scaling down existing larger-scale devices or the "bottom-up' approach assembling the smallest possible building blocks to functional nanoscale entities. For synthetic nanodevices, self-assembly on surfaces is a superb method to achieve useful functions and enable their interactions with the surrounding world. Consequently, adaptability and responsiveness to external stimuli are other prerequisites for their successful operation. Mechanically interlocked molecules such as rotaxanes and catenanes, and their precursors, that is, molecular switches and supramolecular switches including pseudorotaxanes, are molecular machines or prototypes of machines capable of mechanical motion induced by chemical signals, biological inputs, light or redox processes as the external stimuli. Switching of these functional host-guest systems on surfaces becomes a fundamental requirement for artificial molecular machines to work, mimicking the molecular machines in nature, such as proteins and their assemblies operating at dynamic interfaces such as the surfaces of cell membranes. Current research endeavors in material science and technology are focused on developing either a new class of materials or materials with novel/multiple functionalities by shifting host-guest chemistry from solution phase to surfaces. In this Account, we present our most recent attempts of building monolayers of rotaxanes/pseudorotaxanes on surfaces, providing stimuli-induced macroscopic effects and further understanding on the switchable host-guest systems at interfaces. Biocompatible versions of molecular machines based on synthetic macrocycles, such as cucurbiturils, pillararenes, calixarenes, and cyclodextrins, have been employed to form self-assembled monolayers of gates on the surfaces of mesoporous silica nanoparticles to regulate the controlled release of cargo/drug molecules under a range of external stimuli

  2. Nanoparticles functionalized with supramolecular host-guest systems for nanomedicine and healthcare.

    Science.gov (United States)

    Wu, Zilong; Song, Nan; Menz, Ryan; Pingali, Bharadwaj; Yang, Ying-Wei; Zheng, Yuebing

    2015-05-01

    Synthetic macrocyclic host compounds can interact with suitable guest molecules via noncovalent interactions to form functional supramolecular systems. With the synergistic integration of the response of molecules and the unique properties at the nanoscale, nanoparticles functionalized with the host-guest supramolecular systems have shown great potentials for a broad range of applications in the fields of nanoscience and nanotechnology. In this review article, we focus on the applications of the nanoparticles functionalized with supramolecular host-guest systems in nanomedicine and healthcare, including therapeutic delivery, imaging, sensing and removal of harmful substances. A large number of examples are included to elucidate the working mechanisms, advantages, limitations and future developments of the nanoparticle-supramolecule systems in these applications.

  3. Supramolecular Host-Guest System as Ratiometric Fe3+ Ion Sensor Based on Water-Soluble Pillar[5]arene.

    Science.gov (United States)

    Yao, Qianfang; Lü, Baozhong; Ji, Chendong; Cai, Yang; Yin, Meizhen

    2017-10-18

    Developing a specific, ratiometric, and reversible detection method for metal ions is significant to guard against the threat of metal-caused environmental pollution and organisms poisoning. Here a supramolecular host-guest system (WP5⊃G) based on water-soluble pillar[5]arene (WP5) and water-soluble quaternized perylene diimide derivative (G) was constructed. Morphological transformation was achieved during the process of adding WP5 into G aqueous solution, and a fluorescence "turn-off" phenomenon was observed which was caused by supramolecular photoinduced electron transfer (PET). Meanwhile, hydrophobic effect and electrostatic interaction played important roles in this supramolecular process, which was confirmed by isothermal titration calorimeter (ITC) and ζ potential experiments. Furthermore, the supramolecular host-guest system could be a "turn-on" fluorescent probe for Fe 3+ ion detection through the process of interdicting supramolecular PET. Moreover, the Fe 3+ ion detection showed specific, ratiometric, and reversible performances with a detection limit of 2.13 × 10 -7 M, which might have great potentials in biological and environmental monitoring.

  4. Selective Organic and Organometallic Reactions in Water-Soluble Host-Guest Supramolecular Systems

    Energy Technology Data Exchange (ETDEWEB)

    Pluth, Michael D.; Raymond, Kenneth N.; Bergman, Robert G.

    2008-02-16

    Inspired by the efficiency and selectivity of enzymes, synthetic chemists have designed and prepared a wide range of host molecules that can bind smaller molecules with their cavities; this area has become known as 'supramolecular' or 'host-guest' chemistry. Pioneered by Lehn, Cram, Pedersen, and Breslow, and followed up by a large number of more recent investigators, it has been found that the chemical environment in each assembly - defined by the size, shape, charge, and functional group availability - greatly influences the guest-binding characteristics of these compounds. In contrast to the large number of binding studies that have been carried out in this area, the exploration of chemistry - especially catalytic chemistry - that can take place inside supramolecular host cavities is still in its infancy. For example, until the work described here was carried out, very few examples of organometallic reactivity inside supramolecular hosts were known, especially in water solution. For that reason, our group and the group directed by Kenneth Raymond decided to take advantage of our complementary expertise and attempt to carry out metal-mediated C-H bond activation reactions in water-soluble supramolecular systems. This article begins by providing background from the Raymond group in supramolecular coordination chemistry and the Bergman group in C-H bond activation. It goes on to report the results of our combined efforts in supramolecular C-H activation reactions, followed by extensions of this work into a wider range of intracavity transformations.

  5. Field-induced detrapping in disordered organic semiconducting host-guest systems

    NARCIS (Netherlands)

    Cottaar, J.; Coehoorn, R.; Bobbert, P.A.

    2010-01-01

    In a disordered organic semiconducting host-guest material, containing a relatively small concentration of guest molecules acting as traps, the charge transport may be viewed as resulting from carriers that are detrapped from the guest to the host. Commonly used theories include only detrapping due

  6. Mechanical measurement of hydrogen bonded host-guest systems under non-equilibrium, near-physiological conditions.

    Science.gov (United States)

    Naranjo, Teresa; Cerrón, Fernando; Nieto-Ortega, Belén; Latorre, Alfonso; Somoza, Álvaro; Ibarra, Borja; Pérez, Emilio M

    2017-09-01

    Decades after the birth of supramolecular chemistry, there are many techniques to measure noncovalent interactions, such as hydrogen bonding, under equilibrium conditions. As ensembles of molecules rapidly lose coherence, we cannot extrapolate bulk data to single-molecule events under non-equilibrium conditions, more relevant to the dynamics of biological systems. We present a new method that exploits the high force resolution of optical tweezers to measure at the single molecule level the mechanical strength of a hydrogen bonded host-guest pair out of equilibrium and under near-physiological conditions. We utilize a DNA reporter to unambiguously isolate single binding events. The Hamilton receptor-cyanuric acid host-guest system is used as a test bed. The force required to dissociate the host-guest system is ∼17 pN and increases with the pulling rate as expected for a system under non-equilibrium conditions. Blocking one of the hydrogen bonding sites results in a significant decrease of the force-to-break by 1-2 pN, pointing out the ability of the method to resolve subtle changes in the mechanical strength of the binding due to the individual H-bonding components. We believe the method will prove to be a versatile tool to address important questions in supramolecular chemistry.

  7. Organic light-emitting diodes for lighting: High color quality by controlling energy transfer processes in host-guest-systems

    Science.gov (United States)

    Weichsel, Caroline; Reineke, Sebastian; Furno, Mauro; Lüssem, Björn; Leo, Karl

    2012-02-01

    Exciton generation and transfer processes in a multilayer organic light-emitting diode (OLED) are studied in order to realize OLEDs with warm white color coordinates and high color-rendering index (CRI). We investigate a host-guest-system containing four phosphorescent emitters and two matrix materials with different transport properties. We show, by time-resolved spectroscopy, that an energy back-transfer from the blue emitter to the matrix materials occurs, which can be used to transport excitons to the other emitter molecules. Furthermore, we investigate the excitonic and electronic transfer processes by designing suitable emission layer stacks. As a result, we obtain an OLED with Commission Internationale de lÉclairage (CIE) coordinates of (0.444;0.409), a CRI of 82, and a spectrum independent of the applied current. The OLED shows an external quantum efficiency of 10% and a luminous efficacy of 17.4 lm/W at 1000 cd/m2.

  8. Selectivity and stoichiometry boosting of beta-cyclodextrin in cationic/anionic surfactant systems: when host-guest equilibrium meets biased aggregation equilibrium.

    Science.gov (United States)

    Jiang, Lingxiang; Yu, Caifang; Deng, Manli; Jin, Changwen; Wang, Yilin; Yan, Yun; Huang, Jianbin

    2010-02-18

    Cationic surfactant/anionic surfactant/beta-CD ternary aqueous systems provide a platform for the coexistence of the host-guest (beta-CD/surfactant) equilibrium and the biased aggregation (monomeric/aggregated surfactants) equilibrium. We report here that the interplay between the two equilibria dominates the systems as follows. (1) The biased aggregation equilibrium imposes an apparent selectivity on the host-guest equilibrium, namely, beta-CD has to always selectively bind the major surfactant (molar fraction > 0.5) even if binding constants of beta-CD to the pair of surfactants are quite similar. (2) In return, the host-guest equilibrium amplifies the bias of the aggregation equilibrium, that is, the selective binding partly removes the major surfactant from the aggregates and leaves the aggregate composition approaching the electroneutral mixing stoichiometry. (3) This composition variation enhances electrostatic attractions between oppositely charged surfactant head groups, thus resulting in less-curved aggregates. In particular, the present apparent host-guest selectivity is of remarkably high values, and the selectivity stems from the bias of the aggregation equilibrium rather than the difference in binding constants. Moreover, beta-CD is defined as a "stoichiometry booster" for the whole class of cationic/anionic surfactant systems, which provides an additional degree of freedom to directly adjust aggregate compositions of the systems. The stoichiometry boosting of the compositions can in turn affect or even determine microstructures and macroproperties of the systems.

  9. A supramolecular photosensitizer system based on the host-guest complexation between water-soluble pillar[6]arene and methylene blue for durable photodynamic therapy.

    Science.gov (United States)

    Yang, Kui; Wen, Jia; Chao, Shuang; Liu, Jing; Yang, Ke; Pei, Yuxin; Pei, Zhichao

    2018-06-05

    A supramolecular photosensitizer system WP6-MB was synthesized based on water-soluble pillar[6]arene and the photosensitizer methylene blue (MB) via host-guest interaction. MB can complex with WP6 directly with a high complex constant without further modification. In particular, WP6-MB can reduce the dark toxicity of MB remarkably. Furthermore, it can efficiently overcome photobleaching and extend the time for singlet oxygen production of MB upon light irradiation, which is significant for durable photodynamic therapy.

  10. Charge transport in disordered organic host-guest systems: effects of carrier density and electric field

    NARCIS (Netherlands)

    Yimer, Y.Y.; Bobbert, P.A.; Coehoorn, R.

    2008-01-01

    We investigate charge transport in disordered organic host–guest systems with a bimodal Gaussian density of states (DOS). The energy difference between the two Gaussians defines the trap depth. By solving the Pauli master equation for the hopping of charge carriers on a regular lattice with site

  11. Charge transport in disordered organic host-guest systems: effects of carrier density and electric field

    NARCIS (Netherlands)

    Yimer, Y.Y.; Bobbert, P.A.; Coehoorn, R.

    2009-01-01

    We investigate charge transport in disordered organic host–guest systems with a bimodal Gaussian density of states. The energy difference between the peaks of the two Gaussians defines the trap depth. By solving the Pauli master equation for the hopping of charge carriers on a regular lattice we

  12. Nuclear magnetic resonance titration studies of simple host-guest amine-carboxylic acid systems

    International Nuclear Information System (INIS)

    Mahinay, Myrna S.; Lindoy, Leonard F.

    1999-01-01

    Adduct formation for the open-chain 1,2-diaminoethane and its N-methyl derivatives [N,N-dimethyl-ethylenediamine (N,N-DMEN),N,N'-dimethylethylenediamine (N,N'-DMEN);N,N,N',N'-tetramethyl-ethylenediamine (N,N,N',N'-TMEN)]; 1,4-diaminobutane; diethylenetriamine (DIEN); triethylenetramine (TRIEN); and the carboxylic acid systems in polar CD 3 OH and nonpolar CDCl 3 solvents were elucidated by nmr titration. The stoichiometries of the adducts were found to correspond to the number of nitrogen present in the amine species with the exception of ligand incorporating N-donors of low basicity; that is, whose log K values for the protonated species in water were less than approximately 6 to 7.(Author)

  13. Controlling the Host-Guest Interaction Mode through a Redox Stimulus.

    Science.gov (United States)

    Szalóki, György; Croué, Vincent; Carré, Vincent; Aubriet, Frédéric; Alévêque, Olivier; Levillain, Eric; Allain, Magali; Aragó, Juan; Ortí, Enrique; Goeb, Sébastien; Sallé, Marc

    2017-12-18

    A proof-of-concept related to the redox-control of the binding/releasing process in a host-guest system is achieved by designing a neutral and robust Pt-based redox-active metallacage involving two extended-tetrathiafulvalene (exTTF) ligands. When neutral, the cage is able to bind a planar polyaromatic guest (coronene). Remarkably, the chemical or electrochemical oxidation of the host-guest complex leads to the reversible expulsion of the guest outside the cavity, which is assigned to a drastic change of the host-guest interaction mode, illustrating the key role of counteranions along the exchange process. The reversible process is supported by various experimental data ( 1 H NMR spectroscopy, ESI-FTICR, and spectroelectrochemistry) as well as by in-depth theoretical calculations performed at the density functional theory (DFT) level. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  14. Molecular recognition: Comparative study of a tunable host-guest system by using a fluorescent model system and collision-induced dissociation mass spectrometry on dendrimers

    DEFF Research Database (Denmark)

    Pittelkow, M.; Nielsen, C.B.; Broeren, A.C.

    2005-01-01

    Host-guest interactions between the periphery of adamantylurea-functionalized dendrimers (host) and ureido acetic acid derivatives (guest) were shown to be specific, strong and spatially well-defined. The binding becomes stronger when using phosphonic or sulfonic acid derivatives. In the present...... work we have quantified the binding constants for the host-guest interactions between two different host motifs and six different guest molecules. The host molecules, which resemble the periphery of a poly(propylene imine) dendrimer, have been fitted with an anthracene-based fluorescent probe. The two...... host motifs differ in terms of the length of the spacer between a tertiary amine and two ureido functionalities. The guest molecules all contain an acidic moiety (either a carboxylic acid, a phosphonic acid, or a sulfonic acid) and three of them also contain an ureido moiety capable of forming multiple...

  15. Carbohydrate-Based Host-Guest Complexation of Hydrophobic Antibiotics for the Enhancement of Antibacterial Activity.

    Science.gov (United States)

    Jeong, Daham; Joo, Sang-Woo; Shinde, Vijay Vilas; Cho, Eunae; Jung, Seunho

    2017-08-08

    Host-guest complexation with various hydrophobic drugs has been used to enhance the solubility, permeability, and stability of guest drugs. Physical changes in hydrophobic drugs by complexation have been related to corresponding increases in the bioavailability of these drugs. Carbohydrates, including various derivatives of cyclodextrins, cyclosophoraoses, and some linear oligosaccharides, are generally used as host complexation agents in drug delivery systems. Many antibiotics with low bioavailability have some limitations to their clinical use due to their intrinsically poor aqueous solubility. Bioavailability enhancement is therefore an important step to achieve the desired concentration of antibiotics in the treatment of bacterial infections. Antibiotics encapsulated in a complexation-based drug delivery system will display improved antibacterial activity making it possible to reduce dosages and overcome the serious global problem of antibiotic resistance. Here, we review the present research trends in carbohydrate-based host-guest complexation of various hydrophobic antibiotics as an efficient delivery system to improve solubility, permeability, stability, and controlled release.

  16. Host-Guest Inclusion Complexes between Amlodipine Enantiomers in the Biphasic Recognition Chiral Extraction System using Tartaric Acid and β-Cyclodextrin Derivatives as Positive Confirmation by using their Enantioselective Extraction.

    Science.gov (United States)

    Al Azzam, Khaldun M; Abdallah, Hassan H; Halim, Hairul N Abdul; Ahmad, Maizatul Akmam; Shaibah, Hassan

    2015-01-01

    The current work reports an extended theoretical study from our previous experimental work for the enantioselective extraction of amlodipine enantiomers in a biphasic recognition chiral extraction system (BRCES) consisting of hydrophobic D-diisopropyl tartrate dissolved in organic phase (n-decanol) and hydrophilic hydroxypropyl-β-cyclodextrin (HP-β-CD) in aqueous phase (acetate buffer) which preferentially recognize the R-enantiomer and S-enantiomer, respectively. The calculations were simulated using a semi-empirical PM3 method as a part of the Gaussian09 software package and were used to optimize the structures of the hosts, guests, and host-guest complexes in the gas phase without any restrictions. It was found that HP-β-CD has the strongest recognition ability among the three β-CD derivatives studied, namely HP-β-CD, hydroxyethyl-β-cyclodextrin (HE-β-CD), and methylated-β-cyclodextrin (Me-β-CD), due to the large interaction energies (Ecomp = -14.3025 kcal/ mol), while D-diisopropyl tartrate has the strongest ability among the four tartaric acid derivatives studied namely; L-diisopropyl tartrate, D-diisopropyl tartrate, L-diethyl tartrate, and D-diethyl tartrate (Ecomp = -5.9964 kcal/ mol). The computational calculations for the enantioselective partitioning of amlodipine enantiomers rationalized the reasons for the different behaviors for this extraction. The present theoretical results may be informative to scientists who are devoting themselves to developing models for their experimental parts or for enhancing the hydrophobic drug solubility in drug delivery systems.

  17. Host-Guest Inclusion Complexes between Amlodipine Enantiomers in the Biphasic Recognition Chiral Extraction System using Tartaric Acid and β-Cyclodextrin Derivatives as Positive Confirmation by using their Enantioselective Extraction

    Science.gov (United States)

    Al Azzam, Khaldun M.; Abdallah, Hassan H.; Halim, Hairul N. Abdul; Ahmad, Maizatul Akmam; Shaibah, Hassan

    2015-01-01

    The current work reports an extended theoretical study from our previous experimental work for the enantioselective extraction of amlodipine enantiomers in a biphasic recognition chiral extraction system (BRCES) consisting of hydrophobic D-diisopropyl tartrate dissolved in organic phase (n-decanol) and hydrophilic hydroxypropyl-β-cyclodextrin (HP-β-CD) in aqueous phase (acetate buffer) which preferentially recognize the R-enantiomer and S-enantiomer, respectively. The calculations were simulated using a semi-empirical PM3 method as a part of the Gaussian09 software package and were used to optimize the structures of the hosts, guests, and host-guest complexes in the gas phase without any restrictions. It was found that HP-β-CD has the strongest recognition ability among the three β-CD derivatives studied, namely HP-β-CD, hydroxyethyl-β-cyclodextrin (HE-β-CD), and methylated-β-cyclodextrin (Me-β-CD), due to the large interaction energies (Ecomp = −14.3025 kcal/ mol), while D-diisopropyl tartrate has the strongest ability among the four tartaric acid derivatives studied namely; L-diisopropyl tartrate, D-diisopropyl tartrate, L-diethyl tartrate, and D-diethyl tartrate (Ecomp = −5.9964 kcal/ mol). The computational calculations for the enantioselective partitioning of amlodipine enantiomers rationalized the reasons for the different behaviors for this extraction. The present theoretical results may be informative to scientists who are devoting themselves to developing models for their experimental parts or for enhancing the hydrophobic drug solubility in drug delivery systems. PMID:26839848

  18. Supramolecular chemistry at interfaces: host-guest interactions for fabricating multifunctional biointerfaces.

    Science.gov (United States)

    Yang, Hui; Yuan, Bin; Zhang, Xi; Scherman, Oren A

    2014-07-15

    CONSPECTUS: Host-guest chemistry can greatly improve the selectivity of biomolecule-ligand binding on account of recognition-directed interactions. In addition, functional structures and the actuation of supramolecular assemblies in molecular systems can be controlled efficiently through various host-guest chemistry. Together, these highly selective, strong yet dynamic interactions can be exploited as an alternative methodology for applications in the field of programmable and controllable engineering of supramolecular soft materials through the reversible binding between complementary components. Many processes in living systems such as biotransformation, transportation of matter, and energy transduction begin with interfacial molecular recognition, which is greatly influenced by various external stimuli at biointerfaces. Detailed investigations about the molecular recognition at interfaces can result in a better understanding of life science, and further guide us in developing new biomaterials and medicines. In order to mimic complicated molecular-recognition systems observed in nature that adapt to changes in their environment, combining host-guest chemistry and surface science is critical for fabricating the next generation of multifunctional biointerfaces with efficient stimuli-responsiveness and good biocompatibility. In this Account, we will summarize some recent progress on multifunctional stimuli-responsive biointerfaces and biosurfaces fabricated by cyclodextrin- or cucurbituril-based host-guest chemistry and highlight their potential applications including drug delivery, bioelectrocatalysis, and reversible adsorption and resistance of peptides, proteins, and cells. In addition, these biointerfaces and biosurfaces demonstrate efficient response toward various external stimuli, such as UV light, pH, redox chemistry, and competitive guests. All of these external stimuli can aid in mimicking the biological stimuli evident in complex biological environments

  19. Engineering responsive polymer building blocks with host-guest molecular recognition for functional applications.

    Science.gov (United States)

    Hu, Jinming; Liu, Shiyong

    2014-07-15

    further broadened responsiveness to external stimuli and accordingly more sophisticated functions. In this Account, we summarize recent progress in the field of responsive polymeric materials containing host-guest recognition motifs with selected examples and highlight their versatile functional applications, whereas small molecule-oriented host-guest supramolecular systems are excluded. We demonstrate how the introduction of host-guest chemistry into conventional polymer systems can modulate their responsive modes to external stimuli. Moreover, the responsive specificity and selectivity of polymeric systems can also be inherited from the host-guest recognition motifs, and these features provide extra advantages in terms of function integration. The following discussions are categorized in terms of design and functions, namely, host-guest chemistry toward the fabrication of responsive polymers and assemblies, optical sensing and imaging, drug and gene delivery, and self-healing materials. A concluding remark on future developments is also presented. We wish this prosperous field would incur more original and evolutionary ideas and benefit fundamental research and our daily life in a more convenient way.

  20. Toward Improved Force-Field Accuracy through Sensitivity Analysis of Host-Guest Binding Thermodynamics

    Science.gov (United States)

    Yin, Jian; Fenley, Andrew T.; Henriksen, Niel M.; Gilson, Michael K.

    2015-01-01

    Improving the capability of atomistic computer models to predict the thermodynamics of noncovalent binding is critical for successful structure-based drug design, and the accuracy of such calculations remains limited by non-optimal force field parameters. Ideally, one would incorporate protein-ligand affinity data into force field parametrization, but this would be inefficient and costly. We now demonstrate that sensitivity analysis can be used to efficiently tune Lennard-Jones parameters of aqueous host-guest systems for increasingly accurate calculations of binding enthalpy. These results highlight the promise of a comprehensive use of calorimetric host-guest binding data, along with existing validation data sets, to improve force field parameters for the simulation of noncovalent binding, with the ultimate goal of making protein-ligand modeling more accurate and hence speeding drug discovery. PMID:26181208

  1. Host-guest complexes between cucurbit[n]urils and acetanilides having aminopropyl units.

    Science.gov (United States)

    Buaki-Sogo, Mireia; Montes-Navajas, Pedro; Alvaro, Mercedes; Garcia, Hermenegildo

    2013-06-01

    2-(Propylamino)acetamide of aniline (1a), and bis-2-(propylamino)acetamide of ortho- (1b) and para-(1c) phenylenediamine form host-guest complexes with CB[6], CB[7] and CB[8] as evidenced by the variations in the (1)H NMR spectroscopy chemical shifts and observation in MALDI-TOF-MS and ESI-MS of ions at the corresponding mass. Binding constants for the 1:1 complexes were estimated from fluorescence titrations and were in the range 10(5)-10(6)M(-1). Models based on molecular mechanics for these supramolecular complexes are provided. In spite of the different geometries arising from the ortho- or para-substitution, phenylenediamides form complexes of similar strength in which the hydrophobic alkyl chains are accommodated inside the host cavity. Formation of these host-guest complexes in the solid state was also achieved by modifying an aminopropyl silica with chloroacetanilides and preparing three silica having analogues of compounds 1a-c anchored to the solid particles. Titrations showed, however, that these solids can adsorb a large percentage of CBs by unselective interactions that are not related to the formation of inclusion complexes. Copyright © 2013 Elsevier Inc. All rights reserved.

  2. Paramagnetic NMR investigation of dendrimer-based host-guest interactions.

    Directory of Open Access Journals (Sweden)

    Fei Wang

    Full Text Available In this study, the host-guest behavior of poly(amidoamine (PAMAM dendrimers bearing amine, hydroxyl, or carboxylate surface functionalities were investigated by paramagnetic NMR studies. 2,2,6,6-Tetramethylpiperidinyloxy (TEMPO derivatives were used as paramagnetic guest molecules. The results showed that TEMPO-COOH significantly broaden the ¹H NMR peaks of amine- and hydroxyl-terminated PAMAM dendrimers. In comparison, no paramagnetic relaxation enhancement (PRE was observed between TEMPO-NH₂, TEMPO-OH and the three types of PAMAM dendrimers. The PRE phenomenon observed is correlated with the encapsulation of TEMPO-COOH within dendrimer pockets. Protonation of the tertiary amine groups within PAMAM dendrimers plays an important role during this process. Interestingly, the absence of TEMPO-COOH encapsulation within carboxylate-terminated PAMAM dendrimer is observed due to the repulsion of TEMPO-COO- anion and anionic dendrimer surface. The combination of paramagnetic probes and ¹H NMR linewidth analysis can be used as a powerful tool in the analysis of dendrimer-based host-guest systems.

  3. Supra-dendron Gelator Based on Azobenzene-Cyclodextrin Host-Guest Interactions: Photoswitched Optical and Chiroptical Reversibility.

    Science.gov (United States)

    Xie, Fan; Ouyang, Guanghui; Qin, Long; Liu, Minghua

    2016-12-12

    A novel amphiphilic dendron (AZOC 8 GAc) with three l-glutamic acid units and an azobenzene moiety covalently linked by an alkyl spacer has been designed. The compound formed hydrogels with water at very low concentration and self-assembled into chiral-twist structures. The gel showed a reversible macroscopic volume phase transition in response to pH variations and photo-irradiation. During the photo-triggered changes, although the gel showed complete reversibility in its optical absorptions, only an incomplete chiroptical property change was achieved. On the other hand, the dendron could form a 1:1 inclusion complex through a host-guest interaction with α-cyclodextrin (α-CD), designated as supra-dendron gelator AZOC 8 GAc/α-CD. The supra-dendron showed similar gelation behavior to that of AZOC 8 GAc, but with enhanced photoisomerization-transition efficiency and chiroptical switching capacity, which was completely reversible in terms of both optical and chiroptical performances. The self-assembly of the supra-dendron is a hierarchical or multi-supramolecular self-assembling process. This work has clearly illustrated that the hierarchical and multi-supramolecular self-assembling system endows the supramolecular nanostructures or materials with superior reversible optical and chiroptical switching. © 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  4. Mechanism of host-guest complexation by cucurbituril.

    Science.gov (United States)

    Márquez, César; Hudgins, Robert R; Nau, Werner M

    2004-05-12

    The factors affecting host-guest complexation between the molecular container compound cucurbit[6]uril (CB6) and various guests in aqueous solution are studied, and a detailed complexation mechanism in the presence of cations is derived. The formation of the supramolecular complex is studied in detail for cyclohexylmethylammonium ion as guest. The kinetics and thermodynamics of complexation is monitored by NMR as a function of temperature, salt concentration, and cation size. The binding constants and the ingression rate constants decrease with increasing salt concentration and cation-binding constant, in agreement with a competitive binding of the ammonium site of the guest and the metal cation with the ureido carbonyl portals of CB6. Studies as a function of guest size indicate that the effective container volume of the CB6 cavity is approximately 105 A(3). It is suggested that larger guests are excluded for two reasons: a high activation barrier for ingression imposed by the tight CB6 portals and a destabilization of the complex due to steric repulsion inside. For example, in the case of the nearly spherical azoalkane homologues 2,3-diazabicyclo[2.2.1]hept-2-ene (DBH, volume ca. 96 A(3)) and 2,3-diazabicyclo[2.2.2]oct-2-ene (DBO, volume ca. 110 A(3)), the former forms the CB6 complex promptly with a sizable binding constant (1300 M(-1)), while the latter does not form a complex even after several months at optimized complexation conditions. Molecular mechanics calculations are performed for several CB6/guest complexes. A qualitative agreement is found between experimental and calculated activation energies for ingression as a function of both guest size and state of protonation. The potential role of constrictive binding by CB6 is discussed.

  5. Separation of radionuclides using host-guest materials

    International Nuclear Information System (INIS)

    Drabova, V.

    2014-01-01

    This thesis is focused on the development of complex procedure with using commercially available sorbents to separate anthropogenic actinides 237 Np, 241 Am, 238 Pu and 239 , 240 Pu and their determination in the liquid radioactive wastes by using alpha spectrometry. Abilities of using commercially available sorbent AnaLig(R)Pu-02 gel from IBC Advanced Technologies, Inc. were tested, this product belongs to host-guest materials based on molecular recognition technology. This material is capable of selectively capturing actinides in oxidation state IV. To adjust the oxidation state of 238 Pu and 239 , 240 Pu was used NaNO 2 . Pu(IV) forms in the medium of nitric acid complexes, [Np(NO 3 ) 6 ] - , which are captured on the column. For the second monitored radionuclide, neptunium is typical valence V, Np(V) in the concentrated nitric acid produces strong complexes, [Np(NO 3 ) 6 ] - , which are capable of the sorption on the column of AnaLig(R)Pu-02 gel. The most common state of americium in aqueous solutions is III. Whereas in this oxidation state, americium do not form complexes in 8 mol·dm -3 nitric acid is the result of the flow-through. On the base of experimental obtained results, solution of 0.1 mol·dm -3 NH 4 I in 9 mol·dm -3 HCl was selected for elution of plutonium. Neptunium was eluted from the column using 9 mol·dm -3 of HCl with addition of 0.5 cm 3 TiCl 3 . Optimizing conditions for the separation procedure was performed by using model solution of radioactive waste which was prepared according to the chemical composition of radioactive concentrate from NPP Mochovce and NPP Bohunice. The effect of the concentration of Fe 3+ , the effect of the concentration of the HCl, the effect of the concentration of the solution of NH 4 I and the effect of the volume of this solution to the yields of 238 Pu were studied. And also was studied the effect of 9 mol·dm -3 of HCl and the effect of volume of 15 % TiCl 3 to the yields of 237 Np. Sorbent DGA(R) Resin from

  6. Host-Guest Inclusion Complexes between Amlodipine Enantiomers in Biphasic Recognition Chiral Extraction System using Tartaric Acid and β-Cyclodextrin Derivatives as Positive Confirmation Using of their Enantioselective Extraction

    OpenAIRE

    AZZAM, Khaldun; ABDALLAH, Hassan; HALIM, Hairul; AHMAD, Maizatul; SHAIBAH, Hassan

    2015-01-01

    The current work reports an extended theoretical study from our previous experimental work for the enantioselective extraction of amlodipine enantiomers in a biphasic recognition chiral extraction system (BRCES) consisting of hydrophobic D-diisopropyl tartrate dissolved in organic phase (n-decanol) and hydrophilic hydroxypropyl-?-cyclodextrin (HP-?-CD) in aqueous phase (acetate buffer) which preferentially recognize the R-enantiomer and S-enantiomer, respectively. The calculations were simula...

  7. Pressure-induced chemistry in a nitrogen-hydrogen host-guest structure

    Science.gov (United States)

    Spaulding, Dylan K.; Weck, Gunnar; Loubeyre, Paul; Datchi, Fréderic; Dumas, Paul; Hanfland, Michael

    2014-12-01

    New topochemistry in simple molecular systems can be explored at high pressure. Here we examine the binary nitrogen/hydrogen system using Raman spectroscopy, synchrotron X-ray diffraction, synchrotron infrared microspectroscopy and visual observation. We find a eutectic-type binary phase diagram with two stable high-pressure van der Waals compounds, which we identify as (N2)6(H2)7 and N2(H2)2. The former represents a new type of van der Waals host-guest compound in which hydrogen molecules are contained within channels in a nitrogen lattice. This compound shows evidence for a gradual, pressure-induced change in bonding from van der Waals to ionic interactions near 50 GPa, forming an amorphous dinitrogen network containing ionized ammonia in a room-temperature analogue of the Haber-Bosch process. Hydrazine is recovered on decompression. The nitrogen-hydrogen system demonstrates the potential for new pressure-driven chemistry in high-pressure structures and the promise of tailoring molecular interactions for materials synthesis.

  8. Host-Guest Interaction between Corona[n]arene and Bisquaternary Ammonium Derivatives for Fabricating Supra-Amphiphile.

    Science.gov (United States)

    Zeng, Lingda; Guo, Qing-Hui; Feng, Yuanning; Xu, Jiang-Fei; Wei, Yuhan; Li, Zhibo; Wang, Mei-Xiang; Zhang, Xi

    2017-06-13

    The interactions between a host, water-soluble corona[n]arene (S6-CAP), and a series of guests, bisquaternary ammonium derivatives (CnDAs), in water, were investigated. The host and guest can form 1:1 host-guest complex. Their binding constants decrease as the alkyl length of CnDAs increases, which can be tunable ranging from 10 3 to 10 6 M -1 . The binding processes are mainly entropy-driven, while the enthalpy changes also play an important role in enhancing the host-guest interactions. In addition, a supra-amphiphile was fabricated with S6-CAP and a normal surfactant bearing bisquaternary ammonium (C4R). The S6-CAP·C4R complex forms micellar aggregates in water, and the system possesses better assembling activity and dilution stability than its building block C4R. This study enriches the families of supra-amphiphiles with a new architecture, and employing such a supra-amphiphile in biofunctional materials is highly anticipated.

  9. Host-guest chemistry of dendrimer-drug complexes. 2. Effects of molecular properties of guests and surface functionalities of dendrimers.

    Science.gov (United States)

    Hu, Jingjing; Cheng, Yiyun; Wu, Qinglin; Zhao, Libo; Xu, Tongwen

    2009-08-06

    The host-guest chemistry of dendrimer-drug complexes is investigated by NMR techniques, including (1)H NMR and 2D-NOESY studies. The effects of molecular properties of drug molecules (protonation ability and spatial steric hindrance of charged groups) and surface functionalities of dendrimers (positively charged amine groups and negatively charged carboxylate groups) on the host-guest interactions are discussed. Different interaction mechanisms between dendrimers and drug molecules are proposed on the basis of NMR results. Primary amine- and secondary amine-containing drugs preferentially bind to negatively charged dendrimers by strong electrostatic interactions, whereas tertiary amine and quaternary ammonium-containing drugs have weak binding ability with dendrimers due to relatively low protonation ability of the tertiary amine group and serious steric hindrance of the quaternary ammonium group. Positively charged drugs locate only on the surface of negatively charged dendrimers, whereas negatively charged drugs locate both on the surface and in the interior cavities of positively charged dendrimers. The host-guest chemistry of dendrimer-drug complexes is promising for the development of new drug delivery systems.

  10. The synthesis and host-guest applications of synthetic receptor molecules

    Science.gov (United States)

    Osner, Zachary R.

    2011-12-01

    Host-guest chemistry involves the complimentary binding between two molecules. Host molecules have been synthesized to bind negative, positive, and neutral molecules such as proteins and enzymes, and have been used as optical sensors, electrochemical sensors, supramolecular catalysts, and in the pharmaceutical industry as anti-cancer agents.1 The field of nanoscience has exploited guest-host interactions to create optical sensors with colloidal gold and Dip-Pen nanolithography technologies. Gold nanoparticles, have been functionalized with DNA, and have been developed as a selective colorimetric detection system, that upon binding turns the solution from a red to blue in color.2 Cyclotriveratrylene (CTV) 1 is a common supramolecular scaffold that has been previously employed in guest-host chemistry, and the construction of CTV involves the cyclic trimerization of veratryl alcohol via the veratryl cation.3 Due to the rigid bowl shaped structure of CTV, CTV has been shown to act as a host molecule for fullerene-C60.4 Lectin binding receptor proteins are a specific class of proteins found in bacteria, viruses, plants, and animals that can bind to complimentary carbohydrates. It is these lectins that are believed to be responsible for cell-cell interactions and the formation of biofilms in pathenogenic bacteria.5 P. aeruginosa is a pathenogenic bacterium, shown to have a high resistance to many antibiotics, which can form biofilms in human lung tissue, causing respiratory tract infections in patients with compromised immune systems. 5 I will exploit guest-host interactions to create synthetic supramolecular and carbohydrate receptor molecules to that will be of use as biological sensing devices via self-assembled monolayers on solid surfaces and nanoparticle technologies. *Please refer to dissertation for references/footnotes.

  11. Porphyrinic supramolecular daisy chains incorporating pillar[5]arene-viologen host-guest interactions

    KAUST Repository

    Fathalla, Maher; Strutt, Nathan; Srinivasan, Sampath; Katsiev, Khabiboulakh; Hartlieb, Karel J.; Bakr, Osman; Stoddart, J. Fraser

    2015-01-01

    A porphyrin functionalised with pillar[5]arene and a viologen at its 5- and 15-meso positions assembles in a head-to-tail manner, producing linear supramolecular daisy chains in dichloromethane. At high concentrations, it forms an organogel which has been investigated by electron microscopy and rheological measurements, paving the way for the preparation of other functional supramolecular assemblies which harness viologen"⊂" pillararene host-guest interactions.

  12. Porphyrinic supramolecular daisy chains incorporating pillar[5]arene-viologen host-guest interactions

    KAUST Repository

    Fathalla, Maher

    2015-05-18

    A porphyrin functionalised with pillar[5]arene and a viologen at its 5- and 15-meso positions assembles in a head-to-tail manner, producing linear supramolecular daisy chains in dichloromethane. At high concentrations, it forms an organogel which has been investigated by electron microscopy and rheological measurements, paving the way for the preparation of other functional supramolecular assemblies which harness viologen"⊂" pillararene host-guest interactions.

  13. Reversible Guest Exchange Mechanisms in Supramolecular Host-GuestAssemblies

    Energy Technology Data Exchange (ETDEWEB)

    Pluth, Michael D.; Raymond, Kenneth N.

    2006-09-01

    Synthetic chemists have provided a wide array of supramolecular assemblies able to encapsulate guest molecules. The scope of this tutorial review focuses on supramolecular host molecules capable of reversibly encapsulating polyatomic guests. Much work has been done to determine the mechanism of guest encapsulation and guest release. This review covers common methods of monitoring and characterizing guest exchange such as NMR, UV-VIS, mass spectroscopy, electrochemistry, and calorimetry and also presents representative examples of guest exchange mechanisms. The guest exchange mechanisms of hemicarcerands, cucurbiturils, hydrogen-bonded assemblies, and metal-ligand assemblies are discussed. Special attention is given to systems which exhibit constrictive binding, a motif common in supramolecular guest exchange systems.

  14. Can we beat the biotin-avidin pair?: cucurbit[7]uril-based ultrahigh affinity host-guest complexes and their applications.

    Science.gov (United States)

    Shetty, Dinesh; Khedkar, Jayshree K; Park, Kyeng Min; Kim, Kimoon

    2015-12-07

    The design of synthetic, monovalent host-guest molecular recognition pairs is still challenging and of particular interest to inquire into the limits of the affinity that can be achieved with designed systems. In this regard, cucurbit[7]uril (CB[7]), an important member of the host family cucurbit[n]uril (CB[n], n = 5-8, 10, 14), has attracted much attention because of its ability to form ultra-stable complexes with multiple guests. The strong hydrophobic effect between the host cavity and guests, ion-dipole and dipole-dipole interactions of guests with CB portals helps in cooperative and multiple noncovalent interactions that are essential for realizing such strong complexations. These highly selective, strong yet dynamic interactions can be exploited in many applications including affinity chromatography, biomolecule immobilization, protein isolation, biological catalysis, and sensor technologies. In this review, we summarize the progress in the development of high affinity guests for CB[7], factors affecting the stability of complexes, theoretical insights, and the utility of these high affinity pairs in different challenging applications.

  15. Incommensurate host-guest structures in compressed elements: Hume—Rothery effects as origin

    International Nuclear Information System (INIS)

    Degtyareva, V F

    2015-01-01

    Discovery of the incommensurate structure in the element Ba under pressure 15 years ago was followed by findings of a series of similar structures in other compressed elements. Incommensurately modulated structures of the host-guest type consist of a tetragonal host structure and a guest structure. The guest structure forms chains of atoms embedded in the channels of host atoms so that the axial ratio of these subcells along the c axis is not rational. Two types of the host-guest structures have been found so far: with the host cells containing 8 atoms and 16 atoms; in these both types the guest cells contain 2 atoms. These crystal structures contain a non-integer number of atoms in their unit cell: tI11* in Bi, Sb, As, Ba, Sr, Sc and tI19* in Na, K, Rb. We consider here a close structural relationship of these host-guest structures with the binary alloy phase Au 3 Cd 5 -tI32. This phase is related to the family of the Hume-Rothery phases that is stabilized by the Fermi sphere-Brillouin zone interaction. From similar considerations for alkali and alkaline-earth elements a necessary condition for structural stability emerges in which the valence electrons band overlaps with the upper core electrons and the valence electron count increases under compression. (paper)

  16. Defined Host-Guest Chemistry on Nanocarbon for Sustained Inhibition of Cancer.

    Science.gov (United States)

    Ostadhossein, Fatemeh; Misra, Santosh K; Mukherjee, Prabuddha; Ostadhossein, Alireza; Daza, Enrique; Tiwari, Saumya; Mittal, Shachi; Gryka, Mark C; Bhargava, Rohit; Pan, Dipanjan

    2016-08-22

    Signal transducer and activator of transcription factor 3 (STAT-3) is known to be overexpressed in cancer stem cells. Poor solubility and variable drug absorption are linked to low bioavailability and decreased efficacy. Many of the drugs regulating STAT-3 expression lack aqueous solubility; hence hindering efficient bioavailability. A theranostics nanoplatform based on luminescent carbon particles decorated with cucurbit[6]uril is introduced for enhancing the solubility of niclosamide, a STAT-3 inhibitor. The host-guest chemistry between cucurbit[6]uril and niclosamide makes the delivery of the hydrophobic drug feasible while carbon nanoparticles enhance cellular internalization. Extensive physicochemical characterizations confirm successful synthesis. Subsequently, the host-guest chemistry of niclosamide and cucurbit[6]uril is studied experimentally and computationally. In vitro assessments in human breast cancer cells indicate approximately twofold enhancement in IC 50 of drug. Fourier transform infrared and fluorescence imaging demonstrate efficient cellular internalization. Furthermore, the catalytic biodegradation of the nanoplatforms occur upon exposure to human myeloperoxidase in short time. In vivo studies on athymic mice with MCF-7 xenograft indicate the size of tumor in the treatment group is half of the controls after 40 d. Immunohistochemistry corroborates the downregulation of STAT-3 phosphorylation. Overall, the host-guest chemistry on nanocarbon acts as a novel arsenal for STAT-3 inhibition. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  17. Energy-cascade organic photovoltaic devices incorporating a host-guest architecture.

    Science.gov (United States)

    Menke, S Matthew; Holmes, Russell J

    2015-02-04

    In planar heterojunction organic photovoltaic devices (OPVs), broad spectral coverage can be realized by incorporating multiple molecular absorbers in an energy-cascade architecture. Here, this approach is combined with a host-guest donor layer architecture previously shown to optimize exciton transport for the fluorescent organic semiconductor boron subphthalocyanine chloride (SubPc) when diluted in an optically transparent host. In order to maximize the absorption efficiency, energy-cascade OPVs that utilize both photoactive host and guest donor materials are examined using the pairing of SubPc and boron subnaphthalocyanine chloride (SubNc), respectively. In a planar heterojunction architecture, excitons generated on the SubPc host rapidly energy transfer to the SubNc guest, where they may migrate toward the dissociating, donor-acceptor interface. Overall, the incorporation of a photoactive host leads to a 13% enhancement in the short-circuit current density and a 20% enhancement in the power conversion efficiency relative to an optimized host-guest OPV combining SubNc with a nonabsorbing host. This work underscores the potential for further design refinements in planar heterojunction OPVs and demonstrates progress toward the effective separation of functionality between constituent OPV materials.

  18. A host-guest-recognition-based electrochemical aptasensor for thrombin detection.

    Science.gov (United States)

    Fan, Hao; Li, Hui; Wang, Qingjiang; He, Pingang; Fang, Yuzhi

    2012-05-15

    A sensitive electrochemical aptasensor for thrombin detection is presented based on the host-guest recognition technique. In this sensing protocol, a 15 based thrombin aptamer (ab. TBA) was dually labeled with a thiol at its 3' end and a 4-((4-(dimethylamino)phenyl)azo) benzoic acid (dabcyl) at its 5' end, respectively, which was previously immobilized on one Au electrode surface by AuS bond and used as the thrombin probe during the protein sensing procedure. One special electrochemical marker was prepared by modifying CdS nanoparticle with β-cyclodextrins (ab. CdS-CDs), which employed as electrochemical signal provider and would conjunct with the thrombin probe modified electrode through the host-guest recognition of CDs to dabcyl. In the absence of thrombin, the probe adopted linear structure to conjunct with CdS-CDs. In present of thrombin, the TBA bond with thrombin and transformed into its special G-quarter structure, which forced CdS-CDs into the solution. Therefore, the target-TBA binding event can be sensitively transduced via detecting the electrochemical oxidation current signal of Cd of CdS nanoparticles in the solution. Using this method, as low as 4.6 pM thrombin had been detected. Copyright © 2012 Elsevier B.V. All rights reserved.

  19. Vibrational spectroscopic and quantum theoretical study of host-guest interactions in clathrates: I. Hofmann type clathrates

    Directory of Open Access Journals (Sweden)

    VLADIMIR M. PETRUSEVSKI

    2000-06-01

    Full Text Available Hofmann type clatharates are host-guest compounds with the general formula M(NH32M'(CN4·2G, in which M(NH32M'(CN4 is the host lattice and G is benzene, the guest molecule. In previous studies, host-guest interactions have been investigated by analyzing the RT and LNT vibrational (infrared, far infrared and Raman spectra of these clathrates. All the observed changes in the vibrational spectra of these clathrates are referred to a host-guest interaction originating from weak hydrogen bonding between the ammonia hydrogen atoms from the host lattice and the p electron cloud of the guest (benzene molecules. In order to obtain an insight into the relative importance of the local crystalline field vs. the anharmonicity effects on the spectroscopic properties of the guest species upon enclathration, as well as to explain the observed band shifts and splittings, several quantum theoretical approaches are proposed.

  20. Investigation of the host-guest complexation between 4-sulfocalix[4]arene and nedaplatin for potential use in drug delivery

    Science.gov (United States)

    Fahmy, Sherif Ashraf; Ponte, Fortuna; Abd El-Rahman, Mohamed K.; Russo, Nino; Sicilia, Emilia; Shoeib, Tamer

    2018-03-01

    Macromolecules including macrocyclic species have been reported to have the potential to encapsulate biologically active compounds such as drugs through host-guest complexation to increase their solubility, stability and bioavailability. In this paper the first experimental and theoretical investigation of the complexation between nedaplatin, a second generation antineoplastic drug, and p-4-sulfocalix[4]arene, a macromolecule possessing a bipolar amphiphilic structure with good biocompatibility and relatively low haemolytic toxicity for potential use as a drug delivery system is presented. Data from 1H NMR, UV, Job's plot analysis, HPLC and DFT calculations are detailed and suggest the formation of a 1:1 complex. The stability constant of the complex was experimentally estimated to be 3.6 × 104 M- 1 and 2.1 × 104 M- 1 which correspond to values of - 6.2 and - 5.9 kcal mol- 1, respectively for the free energy of complexation while the interaction free energy is calculated to be - 4.9 kcal mol- 1. The formed species is shown to be stabilised in solution through hydrogen bonding between the host and the guest which may allow for this strategy to be effective for potential use in drug delivery.

  1. Through-Space Paramagnetic NMR Effects in Host-Guest Complexes: Potential Ruthenium(III) Metallodrugs with Macrocyclic Carriers.

    Science.gov (United States)

    Chyba, Jan; Novák, Martin; Munzarová, Petra; Novotný, Jan; Marek, Radek

    2018-04-05

    The potential of paramagnetic ruthenium(III) compounds for use as anticancer metallodrugs has been investigated extensively during the past several decades. However, the means by which these ruthenium compounds are transported and distributed in living bodies remain relatively unexplored. In this work, we prepared several novel ruthenium(III) compounds with the general structure Na + [ trans-Ru III Cl 4 (DMSO)(L)] - (DMSO = dimethyl sulfoxide), where L stands for pyridine or imidazole linked with adamantane, a hydrophobic chemophore. The supramolecular interactions of these compounds with macrocyclic carriers of the cyclodextrin (CD) and cucurbit[ n]uril (CB) families were investigated by NMR spectroscopy, X-ray diffraction analysis, isothermal titration calorimetry, and relativistic DFT methods. The long-range hyperfine NMR effects of the paramagnetic guest on the host macrocycle are related to the distance between them and their relative orientation in the host-guest complex. The CD and CB macrocyclic carriers being studied in this account can be attached to a vector that attracts the drug-carrier system to a specific biological target and our investigation thus introduces a new possibility in the field of targeted delivery of anticancer metallodrugs based on ruthenium(III) compounds.

  2. Host-guest chemistry of dendrimer-drug complexes: 7. Formation of stable inclusions between acetylated dendrimers and drugs bearing multiple charges.

    Science.gov (United States)

    Fang, Min; Zhang, Jiahai; Wu, Qinglin; Xu, Tongwen; Cheng, Yiyun

    2012-03-15

    Drug molecules bearing multiple charges usually form precipitates with cationic dendrimers, which presents a challenge during the preparation of dendrimer inclusions for these drugs. In the present study, fully acetylated polyamidoamine (PAMAM) dendrimers were proposed as stable vehicles for drug molecules bearing two negative charges such as Congo red and indocyanine green. NMR techniques including (1)H NMR and (1)H-(1)H NOESY were used to characterize the host-guest chemistry of acetylated dendrimer and these guest molecules. The cationic PAMAM dendrimer was found to form a precipitate with Congo red and indocyanine green, but the acetylated one avoided the formation of cross-linking structures in aqueous solutions. NOESY studies revealed the encapsulation of Congo red and indocyanine green within the interior cavities of PAMAM dendrimers at mild acidic conditions and acetylated dendrimers show much stronger ability to encapsulate the guest molecules than cationic ones. Also, UV-vis-NIR studies suggest that acetylated dendrimers significantly improve the photostability of indocyanine green and prevent the formation of indocyanine green J-aggregates in aqueous solutions. The present study provides a new insight into dendrimer-based host-guest systems, especially for those guest molecules bearing multiple charges. © 2012 American Chemical Society

  3. Driving Forces Controlling Host-Guest Recognition in Supercritical Carbon Dioxide Solvent.

    Science.gov (United States)

    Ingrosso, Francesca; Altarsha, Muhannad; Dumarçay, Florence; Kevern, Gwendal; Barth, Danielle; Marsura, Alain; Ruiz-López, Manuel F

    2016-02-24

    The formation of supramolecular host-guest complexes is a very useful and widely employed tool in chemistry. However, supramolecular chemistry in non-conventional solvents such as supercritical carbon dioxide (scCO2 ), one of the most promising sustainable solvents, is still in its infancy. In this work, we explored a successful route to the development of green processes in supercritical CO2 by combining a theoretical approach with experiments. We were able to synthesize and characterize an inclusion complex between a polar aromatic molecule (benzoic acid) and peracetylated-β-cyclodextrin, which is soluble in the supercritical medium. This finding opens the way to wide, environmental friendly, applications of scCO2 in many areas of chemistry, including supramolecular synthesis, reactivity and catalysis, micro and nano-particle formation, molecular recognition, as well as enhanced extraction processes with increased selectivity. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  4. Rational Design of Multifunctional Gold Nanoparticles via Host-Guest Interaction for Cancer-Targeted Therapy.

    Science.gov (United States)

    Chen, Wei-Hai; Lei, Qi; Luo, Guo-Feng; Jia, Hui-Zhen; Hong, Sheng; Liu, Yu-Xin; Cheng, Yin-Jia; Zhang, Xian-Zheng

    2015-08-12

    A versatile gold nanoparticle-based multifunctional nanocomposite AuNP@CD-AD-DOX/RGD was constructed flexibly via host-guest interaction for targeted cancer chemotherapy. The pH-sensitive anticancer prodrug AD-Hyd-DOX and the cancer-targeted peptide AD-PEG8-GRGDS were modified on the surface of AuNP@CD simultaneously, which endowed the resultant nanocomposite with the capability to selectively eliminate cancer cells. In vitro studies indicated that the AuNP@CD-AD-DOX/RGD nanocomposite was preferentially uptaken by cancer cells via receptor-mediated endocytosis. Subsequently, anticancer drug DOX was released rapidly upon the intracellular trigger of the acid microenvirenment of endo/lysosomes, inducing apoptosis in cancer cells. As the ideal drug nanocarrier, the multifunctional gold nanoparticles with the active targeting and controllable intracellular release ability hold the great potential in cancer therapy.

  5. Hydrogen bonding assemblies in host guest complexes with 18-crown-6

    Science.gov (United States)

    Fonari, M. S.; Simonov, Yu. A.; Kravtsov, V. Ch.; Lipkowski, J.; Ganin, E. V.; Yavolovskii, A. A.

    2003-02-01

    Recent X-ray crystal structural data for two novel 1:2 host-guest complexes of 18-crown-6 with neutral organic molecules, thiaamide hydrazide of 2-aminobenzoic acid and thiaamide hydrazide of 4-amino-1,2,5-thiadiazole-3-carbonic acid are reported. The supramolecular structures of these two and five relative complexes are discussed from the point of view of participation of donor groups in coordination with the crown ether, and donor and acceptor groups in the self-assembly of the guest molecules. Guest molecules have incorporated amine and hydrazine moieties as proton donors and carbonyl oxygen and sulfur (in thiadiazole and in thiaamine moieties) as proton acceptors. The guest-guest interactions appeared to be crucial in the final architecture.

  6. Host-guest interaction of styrene and ethylbenzene in MIL-53 studied by solid-state NMR.

    Science.gov (United States)

    Li, Shenhui; Li, Jing; Tang, Jing; Deng, Feng

    Solid-state NMR was utilized to explore the host-guest interaction between adsorbate and adsorbent at atomic level to understand the separation mechanism of styrene (St) and ethylbenzene (EB) in MIL-53(Al). 13 C- 27 Al double-resonance NMR experiments revealed that the host-guest interaction between St and MIL-53 was much stronger than that of EB adsorption. In addition, 13 C DIPSHIFT experiments suggested that the adsorbed St was less mobile than EB confined inside the MIL-53 pore. Furthermore, the host-guest interaction model between St, EB and MIL-53 was established on the basis of the spatial proximities information extracted from 2D 1 H- 1 H homo-nuclear correlation NMR experiments. According to the experimental observation from solid-state NMR, it was found that the presence of π-π interaction between St and MIL-53 resulted in the stronger host-guest interaction and less mobility of St. This work provides direct experimental evidence for understanding the separation mechanism of St and EB using MIL-53 as an adsorbent. Copyright © 2017 Elsevier Inc. All rights reserved.

  7. A concept for the removal of microplastics from the marine environment with innovative host-guest relationships.

    Science.gov (United States)

    Herbort, Adrian Frank; Schuhen, Katrin

    2017-04-01

    Environmental pollution caused by inert anthropogenic stressors such as microplastics in aquatic media is constantly increasing. Through the proliferating use of plastic products in daily life, more and more plastic particles enter waters as primary microplastics. Even though large scale plastic items such as plastic bottles and bags represent the highest percentage of plastic waste, their degeneration also generates microparticles and nanoparticles (secondary microplastics). Modern sewage treatment plants require innovative ideas in order to deal with this man-made problem. State-of-the-art technology offers approaches to minimise the amount of microplastics in aquatic systems. These technologies, however, are either insufficient or very costly, as well as time-consuming in both cases. The conceptual idea presented here is to apply innovative inorganic-organic hybrid silica gels which provide a cost-effective and straightforward approach. Currently, the synthesis of preorganised bioinspired compounds is advancing in order to produce functionalised hybrid silica gels in a further step. These gels have the ability to remove stressors such as microplastics from waste water. By means of the sol-gel process, bioinspired silane compounds are currently being permuted to macromolecules and examined with respect to their properties as fixation and filter material in order to remove the hydrophobic anthropogenic stressors sustainably. Here, the reproduction of biological systems plays a significant role. In particular in material sciences, this approach is becoming increasingly important. Among other concepts, new biomimetic molecules form the basis for the investigation of innovative host-guest relationships for anthropogenic stressors in the environment and their implementation in technical processes.

  8. Study on luminescence characteristics of blue OLED with phosphor-doped host-guest structure

    Science.gov (United States)

    Wang, Zhen; Liu, Fei; Zheng, Xin; Chen, Ai; Xie, Jia-feng; Zhang, Wen-xia

    2018-05-01

    In this study, we design and fabricate phosphor-doped host-guest structure organic light-emitting diodes (OLEDs), where the blue-ray iridium complex electrophosphorescent material FIrpic acts as object material. Properties of the device can be accommodated by changing the host materials, dopant concentration and thickness of the light-emitting layer. The study shows that the host material N,N'-dicarbazolyl-3,5-benzene (mCP) has a higher triplet excited state energy level, which can effectively prevent FIrpic triplet excited state energy backtracking to host material, thus the luminous efficiency is improved. When mCP is selected as the host material, the thickness of the light-emitting layer is 30 nm and the dopant concentration is 8 wt%, the excitons can be effectively confined in the light-emitting region. As a result, the maximum current efficiency and the maximum brightness of the blue device can reach 15.5 cd/A and 7 196.3 cd/m2, respectively.

  9. Thermosensitive Triterpenoid-Appended Polymers with Broad Temperature Tunability Regulated by Host-Guest Chemistry.

    Science.gov (United States)

    Hao, Jie; Gao, Yuxia; Li, Ying; Yan, Qiang; Hu, Jun; Ju, Yong

    2017-09-05

    Thermoresponsive water-soluble polymers are of great importance since they typically show a lower critical solution temperature (LCST) in aqueous media. In this research, the LCST change in broad temperature ranges of copolymers composed of natural glycyrrhetinic acid (GA)-based methacrylate and N,N'-dimethylacrylamides (DMAs) was investigated as a function of the concentration and the content of GA pendants. By complexation of GA pendants with β-cyclodextrin (β-CD), a side-chain polypseudorotaxane was obtained, which exhibited a significant increase in the LCST of copolymers. Moreover, the precisely reversible control of the LCST behavior was realized through adding a competing guest molecule, sodium 1-admantylcarboxylate. This work illustrates a simple and effective approach to endow water-soluble polymers with broad temperature tunability and helps us further understand the effect of a biocompatible host-guest complementary β-CD/GA pair on the thermoresponsive process. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  10. Host-Guest Interaction of Cucurbit[8]uril with N-(3-Aminopropyl)cyclohexylamine: Cyclohexyl Encapsulation Triggered Ternary Complex.

    Science.gov (United States)

    Xia, Yu; Wang, Chuan-Zeng; Tian, Mengkui; Tao, Zhu; Ni, Xin-Long; Prior, Timothy J; Redshaw, Carl

    2018-01-15

    The host-guest interaction of a series of cyclohexyl-appended guests with cucurbit[8]uril (Q[8]) was studied by ¹H NMR spectroscopy, isothermal titration calorimetry (ITC), and X-ray crystallography. The X-ray structure revealed that two cycloalkane moieties can be simultaneously encapsulated in the hydrophobic cavity of the Q[8] host to form a ternary complex for the first time.

  11. Host-Guest Interaction of Cucurbit[8]uril with N-(3-Aminopropylcyclohexylamine: Cyclohexyl Encapsulation Triggered Ternary Complex

    Directory of Open Access Journals (Sweden)

    Yu Xia

    2018-01-01

    Full Text Available The host-guest interaction of a series of cyclohexyl-appended guests with cucurbit[8]uril (Q[8] was studied by 1H NMR spectroscopy, isothermal titration calorimetry (ITC, and X-ray crystallography. The X-ray structure revealed that two cycloalkane moieties can be simultaneously encapsulated in the hydrophobic cavity of the Q[8] host to form a ternary complex for the first time.

  12. Vibrational spectroscopic and gravimetric study of some Hofmann-CBA-Type Host and host-guest compounds

    International Nuclear Information System (INIS)

    Aytekin, M.A.

    2005-01-01

    In this study, similar to Hofmann type M(C 4 H 7 NH 2 ) 2 Ni(CN) 4 (M=Ni or Co) host and M(C 4 H 7 NH 2 ) 2 Ni(CN) 4 .nG (M=Ni or Co; G=benzene, 1,2-, 1,3-dichlorobenzene; n=the number of guest) hostguest compounds were obtained chemically. The infrared spectra of these compounds were recorded with FT-IR spectrometer in the spectroscopic region of 4000cm-1-400cm-1. From these spectra the vibrational wave numbers of ligand molecule, Ni(CN) 4 2 - ion and guest molecules were determined. The absorption and the liberation processes of the guest molecules in the host compounds were examined at room temperature by gravimetric method. Otherwise, it was seen that the molecular structure was supported by making instrumental analysis of host and some host-guest compounds. By analysing the structures of host and host-guest compounds were found to be similar to those of Hofmann type compounds, ligand molecule cyclobutylamine were coordinated to M metal atom from cyclobutylamine's nitrogen atom, the guest molecules were imprisoned in the structural cavities between the sheets

  13. Smart protein biogate as a mediator to regulate competitive host-guest interaction for sensitive ratiometric electrochemical assay of prion

    Science.gov (United States)

    Yu, Peng; Zhang, Xiaohua; Zhou, Jiawan; Xiong, Erhu; Li, Xiaoyu; Chen, Jinhua

    2015-11-01

    A novel competitive host-guest strategy regulated by protein biogate was developed for sensitive and selective analysis of prion protein. The methylene blue (MB)-tagged prion aptamer (MB-Apt) was introduced to the multiwalled carbon nanotubes-β-cyclodextrins (MWCNTs-β-CD) composites-modified glassy carbon (GC) electrode through the host-guest interaction between β-CD and MB. In the absence of prion, MB-Apt could be displaced by ferrocenecarboxylic acid (FCA) due to its stronger binding affinity to β-CD, resulting in a large oxidation peak of FCA. However, in the presence of prion, the specific prion-aptamer interaction drove the formation of protein biogate to seal the cavity of β-CD, which hindered the guest displacement of MB by FCA and resulted in the oxidation peak current of MB (IMB) increased and that of FCA (IFCA) decreased. The developed aptasensor showed good response towards the target (prion protein) with a low detection limit of 160 fM. By changing the specific aptamers, this strategy could be easily extended to detect other proteins, showing promising potential for extensive applications in bioanalysis.

  14. A targeted nanoglobular contrast agent from host-guest self-assembly for MR cancer molecular imaging.

    Science.gov (United States)

    Zhou, Zhuxian; Han, Zhen; Lu, Zheng-Rong

    2016-04-01

    The clinical application of nanoparticular Gd(III) based contrast agents for tumor molecular MRI has been hindered by safety concerns associated with prolonged tissue retention, although they can produce strong tumor enhancement. In this study, a targeted well-defined cyclodextrin-based nanoglobular contrast agent was developed through self-assembly driven by host-guest interactions for safe and effective cancer molecular MRI. Multiple β-cyclodextrins attached POSS (polyhedral oligomeric silsesquioxane) nanoglobule was used as host molecule. Adamantane-modified macrocyclic Gd(III) contrast agent, cRGD (cyclic RGDfK peptide) targeting ligand and fluorescent probe was used as guest molecules. The targeted host-guest nanoglobular contrast agent cRGD-POSS-βCD-(DOTA-Gd) specifically bond to αvβ3 integrin in malignant 4T1 breast tumor and provided greater contrast enhancement than the corresponding non-targeted agent. The agent also provided significant fluorescence signal in tumor tissue. The histological analysis of the tumor tissue confirmed its specific and effective targeting to αvβ3 integrin. The targeted imaging agent has a potential for specific cancer molecular MR and fluorescent imaging. Copyright © 2016 Elsevier Ltd. All rights reserved.

  15. Host-Guest Recognition-Assisted Electrochemical Release: Its Reusable Sensing Application Based on DNA Cross Configuration-Fueled Target Cycling and Strand Displacement Reaction Amplification.

    Science.gov (United States)

    Chang, Yuanyuan; Zhuo, Ying; Chai, Yaqin; Yuan, Ruo

    2017-08-15

    In this work, an elegantly designed host-guest recognition-assisted electrochemical release was established and applied in a reusable electrochemical biosensor for the detection of microRNA-182-5p (miRNA-182-5p), a prostate cancer biomarker in prostate cancer, based on the DNA cross configuration-fueled target cycling and strand displacement reaction (SDR) amplification. With such a design, the single target miRNA input could be converted to large numbers of single-stranded DNA (S1-Trp and S2-Trp) output, which could be trapped by cucurbit[8]uril methyl viologen (CB-8-MV 2+ ) based on the host-guest recognition, significantly enhancing the sensitivity for miRNA detection. Moreover, the nucleic acids products obtained from the process of cycling amplification could be utilized sufficiently, avoiding the waste and saving the experiment cost. Impressively, by resetting a settled voltage, the proposed biosensor could release S1-Trp and S2-Trp from the electrode surface, attributing that the guest ion methyl viologen (MV 2+ ) was reduced to MV +· under this settled voltage and formed a more-stable CB-8-MV +· -MV +· complex. Once O 2 was introduced in this system, MV +· could be oxidized to MV 2+ , generating the complex of CB-8-MV 2+ for capturing S1-Trp and S2-Trp again in only 5 min. As a result, the simple and fast regeneration of biosensor for target detection was realized on the base of electrochemical redox-driven assembly and release, overcoming the challenges of time-consuming, burdensome operations and expensive experimental cost in traditional reusable biosensors and updating the construction method for a reusable bisensor. Furthermore, the biosensor could be reused for more than 10 times with a regeneration rate of 93.20%-102.24%. After all, the conception of this work provides a novel thought for the construction of effective reusable biosensor to detect miRNA and other biomarkers and has great potential application in the area requiring the release of

  16. Host-guest chemistry of dendrimer-drug complexes. 6. Fully acetylated dendrimers as biocompatible drug vehicles using dexamethasone 21-phosphate as a model drug.

    Science.gov (United States)

    Yang, Kun; Weng, Liang; Cheng, Yiyun; Zhang, Hongfeng; Zhang, Jiahai; Wu, Qinglin; Xu, Tongwen

    2011-03-17

    Fully acetylated poly(amidoamine) (PAMAM) dendrimer was proposed as a biocompatible drug vehicle using dexamethasone 21-phosphate (Dp21) as a model drug. NMR techniques including (1)H NMR and 2D NOE NMR were used to characterize the host-guest chemistry of acetylated dendrimer/Dp21 and cationic dendrimer/Dp21 complexes. The pH-dependent micellization, complexation, and inclusion behaviors of Dp21 were observed in the presence of acetylated and cationic PAMAM dendrimers. Acetylated dendrimer only encapsulates Dp21 at acidic conditions, while cationic dendrimer can host Dp21 at both acidic and neutral conditions. The orientation of Dp21 molecules in the dendrimer cavities depends on the quaternization degree of tertiary amine groups of dendrimer and the protonation ratio of phosphate group of Dp21. A distinctive pH-dependent release behavior of Dp21 from the acetylated and nonacetylated dendritic matrix was observed: Dp21 exhibits a much slower release rate from acetylated dendrimer at lower pH conditions and a much faster release rate from nonacetylated dendrimer with decreasing pH values. Cytotoxicity studies further confirmed the biocompatibility of acetylated dendrimers, which are much safer in the delivery of therapeutics for the treatment of various diseases than nonacetylated dendrimers. The dendrimer-drug binding and release mechanisms provide a new insight for the design and optimization of biocompatible dendrimer-based drug delivery systems. © 2011 American Chemical Society

  17. Host-Guest Engineering of Layered Double Hydroxides towards Efficient Oxygen Evolution Reaction: Recent Advances and Perspectives

    Directory of Open Access Journals (Sweden)

    Jianming Li

    2018-05-01

    Full Text Available Electrochemical water splitting has great potential in the storage of intermittent energy from the sun, wind, or other renewable sources for sustainable clean energy applications. However, the anodic oxygen evolution reaction (OER usually determines the efficiency of practical water electrolysis due to its sluggish four-electron process. Layered double hydroxides (LDHs have attracted increasing attention as one of the ideal and promising electrocatalysts for water oxidation due to their excellent activity, high stability in basic conditions, as well as their earth-abundant compositions. In this review, we discuss the recent progress on LDH-based OER electrocatalysts in terms of active sites, host-guest engineering, and catalytic performances. Moreover, further developments and challenges in developing promising electrocatalysts based on LDHs are discussed from the viewpoint of molecular design and engineering.

  18. Self-assembly behavior of a linear-star supramolecular amphiphile based on host-guest complexation.

    Science.gov (United States)

    Wang, Juan; Wang, Xing; Yang, Fei; Shen, Hong; You, Yezi; Wu, Decheng

    2014-11-04

    A star polymer, β-cyclodextrin-poly(l-lactide) (β-CD-PLLA), and a linear polymer, azobenzene-poly(ethylene glycol) (Azo-PEG), could self-assemble into a supramolecular amphiphilic copolymer (β-CD-PLLA@Azo-PEG) based on the host-guest interaction between β-CD and azobenzene moieties. This linear-star supramolecular amphiphilic copolymer further self-assembled into a variety of morphologies, including sphere-like micelle, carambola-like micelle, naan-like micelle, shuttle-like lamellae, tube-like fiber, and random curled-up lamellae, by tuning the length of hydrophilic or hydrophobic chains. The variation of morphology was closely related to the topological structure and block ratio of the supramolecular amphiphiles. These self-assembly structures could disassemble upon an ultraviolet (UV) light irradiation.

  19. Carbohydrate Nanotechnology: Hierarchical Assemblies and Information Processing with Oligosaccharide-Synthetic Lectin Host-Guest Systems

    Science.gov (United States)

    2013-08-05

    Carbohydrates were explored as targets for synthetic receptors, in nanopatterning, and for directing the movement of nanoswimmers. A synthetic...dimensional movement of rods with translational and rotational diffusion coefficients and Dr respectively, neglecting the difference in...consistent with the previous theories. In the absence of flipping (f = 0), the diffusivity reduces to that of Brownian motion in circles. Neither of

  20. Easily Processed Host-Guest Polymer Systems with High-Tg Characteristics (First-year Report)

    Science.gov (United States)

    2012-05-01

    manner such that the effective electro- optical coefficient is maximized. Unfortunately, relaxation of the chromophore in the host polymer leads to...polished stainless steel facing plates (0.25 in thickness, McMaster ) and window molds cut from aluminum stock (1 mm thickness, McMaster ). Both facing...plasticization from the chromophore. Both chromophores resulted in substantial red-shifted absorption compared to a sample prepared in virgin PMMA. We expect

  1. Deciphering the perturbation effect of urea on the supramolecular host-guest interaction of biologically active hydrophobic molecule inside the nanocavity of cyclodextrins

    Energy Technology Data Exchange (ETDEWEB)

    Maity, Banibrata; Chatterjee, Aninda; Ahmed, Sayeed Ashique; Seth, Debabrata, E-mail: debabrata@iitp.ac.in

    2017-03-15

    The present work articulates the supramolecular interaction and the formation of host-guest complex between the biologically active hydrophobic coumarin derivative and cyclodextrins by using several spectroscopic, calorimetric and microscopic techniques. All the studies clearly revealed that in presence of cyclodextrins (CDs), coumarin forms 1:1 stoichiometric complex. From all the study, we have found that with gradual increasing the cavity diameter of the hosts, the binding efficiency of the complexes gradually increases. The small population of the non emissive twisted intramolecular charge transfer (TICT) state of coumarin molecule turns into highly emissive in presence of γ-CD owing to its greater cavity diameter. The emissive TICT band is not found in β-CD complex due to its comparative small hydrophilic exterior and less polar environment. The present finding also interpret the perturbation effect of urea on host-guest complexes. In the presence of urea, the TICT emissive band of γ-CD is completely diminished. From, {sup 1}H NMR study it was observed that –NEt{sub 2} moiety of 7-DCCAE molecule is deeply buried inside the hydrophobic cavity of the CDs and forms host-guest complexes. Isothermal titration calorimetry measurement also indicates the formation of 1:1 host-guest complexes.

  2. Spatial, Hysteretic, and Adaptive Host-Guest Chemistry in a Metal-Organic Framework with Open Watson-Crick Sites.

    Science.gov (United States)

    Cai, Hong; Li, Mian; Lin, Xiao-Rong; Chen, Wei; Chen, Guang-Hui; Huang, Xiao-Chun; Li, Dan

    2015-09-01

    Biological and artificial molecules and assemblies capable of supramolecular recognition, especially those with nucleobase pairing, usually rely on autonomous or collective binding to function. Advanced site-specific recognition takes advantage of cooperative spatial effects, as in local folding in protein-DNA binding. Herein, we report a new nucleobase-tagged metal-organic framework (MOF), namely ZnBTCA (BTC=benzene-1,3,5-tricarboxyl, A=adenine), in which the exposed Watson-Crick faces of adenine residues are immobilized periodically on the interior crystalline surface. Systematic control experiments demonstrated the cooperation of the open Watson-Crick sites and spatial effects within the nanopores, and thermodynamic and kinetic studies revealed a hysteretic host-guest interaction attributed to mild chemisorption. We further exploited this behavior for adenine-thymine binding within the constrained pores, and a globally adaptive response of the MOF host was observed. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  3. Host-guest complexes of 2-hydroxypropyl-β-cyclodextrin/β-cyclodextrin and nifedipine: 1H NMR, molecular modeling, and dissolution studies

    Science.gov (United States)

    de Araújo, Márcia Valéria Gaspar; Vieira, João Victor Francisco; da Silva, Caroline W. P.; Barison, Andersson; Andrade, George Ricardo Santana; da Costa, Nivan Bezerra; Barboza, Fernanda Malaquias; Nadal, Jessica Mendes; Novatski, Andressa; Farago, Paulo Vitor; Zawadzki, Sônia Faria

    2017-12-01

    Nifedipine (NIF) is a hydrophobic drug widely used for treating cardiovascular diseases. This calcium channel blocker can present a higher apparent solubility by its inclusion into different cyclodextrins (CDs) as host-guest complexes. This paper focused on the structural investigation and dissolution behavior of inclusion complexes prepared with 2-hydroxypropyl-β-cyclodextrin (HPβCD) or β-cyclodextrin (βCD) and NIF. Drug amorphization was observed for HPβCD/NIF and βCD/NIF inclusion complexes by X-ray diffractometry (XRD). The sharp endothermic peak of NIF was not observed for these both host-guest complexes by differential scanning calorimetry (DSC). These results of XRD and DSC provide evidences of complexation between drug and the investigated CDs. 1H and saturation transfer difference nuclear magnetic resonance studies revealed the enhancement in the signal at 2.27 ppm for HPβCD/NIF and βCD/NIF inclusion complexes that corresponded to the methyl groups of NIF from the non-aromatic ring. This result suggested that non-aromatic ring of NIF was inserted into HPβCD and βCD cavities. Considering the mathematical simulations, it was observed that the inclusion process can occur in the both NH-in or NH-out forms. However, since it was used aqueous medium, it is possible to indicate that the obtained host-guest complexes HPβCD/NIF and βCD/NIF are in NH-in form which corresponded to the previous results obtained by 1H NMR experiments. Dissolution assays demonstrated that NIF inclusion complexes improved the drug release nevertheless without changing its biexponential release behavior. These host-guest complexes can be further used as feasible NIF carriers in solid dosage forms.

  4. Host-guest chemistry of dendrimer-drug complexes. 4. An in-depth look into the binding/encapsulation of guanosine monophosphate by dendrimers.

    Science.gov (United States)

    Hu, Jingjing; Fang, Min; Cheng, Yiyun; Zhang, Jiahai; Wu, Qinglin; Xu, Tongwen

    2010-06-03

    In the present study, we investigated the host-guest chemistry of dendrimer/guanosine monophosphate (GMP) and present an in-depth look into the binding/encapsulation of GMP by dendrimers using NMR studies. (1)H NMR spectra showed a significant downfield shift of methylene protons in the outmost layer of the G5 dendrimer, indicating the formation of ion pairs between cationic amine groups of dendrimer and anionic phosphate groups of GMP. Chemical shift titration results showed that the binding constant between G5 dendrimer and GMP is 17,400 M(-1) and each G5 dendrimer has 107 binding sites. The binding of GMP to dendrimers prevents its aggregation in aqueous solutions and thereby enhances its stability. Nuclear Overhauser effect measurements indicated that a GMP binding and encapsulation balance occurs on the surface and in the interior of dendrimer. The binding/encapsulation transitions can be easily tailored by altering the surface and interior charge densities of the dendrimer. All these findings provide a new insight into the host-guest chemistry of dendrimer/guest complexes and may play important roles in the study of dendrimer/DNA aggregates by a "bottom-up" strategy.

  5. Host-Guest Complexes of Cyclodextrins and Nanodiamonds as a Strong Non-Covalent Binding Motif for Self-Assembled Nanomaterials.

    Science.gov (United States)

    Schibilla, Frauke; Voskuhl, Jens; Fokina, Natalie A; Dahl, Jeremy E P; Schreiner, Peter R; Ravoo, Bart Jan

    2017-11-13

    We report the inclusion of carboxy- and amine-substituted molecular nanodiamonds (NDs) adamantane, diamantane, and triamantane by β-cyclodextrin and γ-cyclodextrin (β-CD and γ-CD), which have particularly well-suited hydrophobicity and symmetry for an optimal fit of the host and guest molecules. We studied the host-guest interactions in detail and generally observed 1:1 association of the NDs with the larger γ-CD cavity, but observed 1:2 association for the largest ND in the series (triamantane) with β-CD. We found higher binding affinities for carboxy-substituted NDs than for amine-substituted NDs. Additionally, cyclodextrin vesicles (CDVs) were decorated with d-mannose by using adamantane, diamantane, and triamantane as non-covalent anchors, and the resulting vesicles were compared with the lectin concanavalin A in agglutination experiments. Agglutination was directly correlated to the host-guest association: adamantane showed lower agglutination than di- or triamantane with β-CDV and almost no agglutination with γ-CDV, whereas high agglutination was observed for di- and triamantane with γ-CDV. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  6. Location of MTBE and toluene in the channel system of the zeolite mordenite: Adsorption and host-guest interactions

    Energy Technology Data Exchange (ETDEWEB)

    Arletti, Rossella, E-mail: rossella.arletti@unito.it [Department of Earth Sciences, University of Torino Via Valperga Caluso 35, I-10125, Torino (Italy); Martucci, Annalisa; Alberti, Alberto [Department of Earth Sciences, University of Ferrara, Via G. Saragat 1, I-44100, Ferrara (Italy); Pasti, Luisa; Nassi, Marianna [Department of Chemistry, University of Ferrara, Via L. Borsari 26, I-44100 Ferrara (Italy); Bagatin, Roberto [Research Centre for Non-Conventional Energy-Istituto ENI Donegani, Environmental Technologies, Via Fauser 4, I-28100 Novara (Italy)

    2012-10-15

    This paper reports a study of the location of Methyl Tertiary Butyl Ether (MTBE) and toluene molecules adsorbed in the pores of the organophylic zeolite mordenite from an aqueous solution. The presence of these organic molecules in the zeolite channels was revealed by structure refinement performed by the Rietveld method. About 3 molecules of MTBE and 3.6 molecules of toluene per unit cell were incorporated into the cavities of mordenite, representing 75% and 80% of the total absorption capacity of this zeolite. In both cases a water molecule was localized inside the side pocket of mordenite. The saturation capacity determined by the adsorption isotherms, obtained by batch experiments, and the weight loss given by thermogravimetric (TG) analyses were in very good agreement with these values. The interatomic distances obtained after the structural refinements suggest MTBE could be connected to the framework through a water molecule, while toluene could be bonded to framework oxygen atoms. The rapid and high adsorption of these hydrocarbons into the organophylic mordenite zeolite makes this cheap and environmental friendly material a suitable candidate for the removal of these pollutants from water. - graphical abstract: Location of MTBE (a) and toluene (b) in mordenite channels (projection along the [001] direction). Highlights: Black-Right-Pointing-Pointer We investigated the MTBE and toluene adsorption process into an organophilic zeolite mordenite. Black-Right-Pointing-Pointer The presence of MTBE and toluene in mordenite was determined by X-ray diffraction studies. Black-Right-Pointing-Pointer About 3 molecules of MTBE and 3.6 molecules of toluene per unit cell were incorporated into the zeolite cavities. Black-Right-Pointing-Pointer MTBE is connected to the framework through a water molecule. Black-Right-Pointing-Pointer Toluene is directly bonded to framework oxygen atoms.

  7. Transfer and control of molecular chirality in the 1 : 2 host-guest supramolecular complex consisting of Mg(II)bisporphyrin and chiral diols: the effect of H-bonding on the rationalization of chirality.

    Science.gov (United States)

    Ikbal, Sk Asif; Brahma, Sanfaori; Rath, Sankar Prasad

    2014-11-21

    A clear rationalization of the origin of chirality transfer from an optically active diol guest to an achiral Mg(ii)bisporphyrin host in a series of 1 : 2 host-guest supramolecular complexes has been reported here that has so far remained the most outstanding issue for the chirogenic process.

  8. Novel photoluminescence enzyme immunoassay based on supramolecular host-guest recognition using L-arginine/6-aza-2-thiothymine-stabilized gold nanocluster.

    Science.gov (United States)

    Wang, Youmei; Lu, Minghua; Tang, Dianping

    2018-06-30

    A new photoluminescence (PL) enzyme immunoassay was designed for sensitive detection of aflatoxin B 1 (AFB 1 ) via an innovative enzyme substrate, 6-aza-2-thiothymine-stabilized gold nanocluster (AAT-AuNC) with L-arginine. The enzyme substrate with strong PL intensity was formed through supramolecular host-guest assembly between guanidine group of L-arginine and AAT capped on the surface of AuNC. Upon arginase introduction, the captured L-arginine was hydrolyzed into ornithine and urea, thus resulting in the decreasing PL intensity. Based on this principle, a novel competitive-type immunoreaction was first carried out on AFB 1 -bovine serum albumin (AFB 1 -BSA) conjugate-coated microplate, using arginase-labeled anti-AFB 1 antibody as the competitor. Under the optimum conditions, the PL intensity increased with the increment of target AFB 1 , and allowed the detection of the analyte at concentrations as low as 3.2 pg mL -1 (ppt). Moreover, L-arginine-AAT-AuNC-based PL enzyme immunoassay afforded good reproducibility and acceptable specificity. In addition, the accuracy of this methodology, referring to commercial AFB 1 ELISA kit, was evaluated to analyze naturally contaminated or spiked peanut samples, giving well-matched results between two methods, thus representing a useful scheme for practical application in quantitative monitoring of mycotoxins in foodstuff. Copyright © 2018 Elsevier B.V. All rights reserved.

  9. Three-Dimensional Energy Transport in Highly Luminescent Host-Guest Crystals: A Quantitative Experimental and Theoretical Study

    DEFF Research Database (Denmark)

    Poulsen, Lars; Jazdzyk, M; Communal, J.-E.

    2007-01-01

    process is modeled by a Monte Carlo approach including homo and hetero transfer steps with multi-acceptor distribution. In this dense system, the classical Förster point-dipole approach for energy transfer breaks down, and the hopping rates are therefore calculated on the basis of a quantum...

  10. Poly-N-Heterocyclic Carbene Ligands with Polyaromatic Linkers. Self-Assembly and Host-Guest Chemistry

    OpenAIRE

    Mejuto Nieblas, Carmen

    2017-01-01

    In summary, a series of polytopic ligands based on NHC and MIC ligands have been synthesized in this Doctoral Thesis by means of different synthetic routes that gave rise to systems with very sophisticated architectures. A large variety of metal complexes have been formed based on these salt precursors that allowed the preparation of homo and heteroleptic mono-, di- and tri-metal complexes with different geometries. The luminescence properties of various imidazolium salts, the catalytic activ...

  11. Theoretical exploration of the nanoscale host-guest interactions between [n]cycloparaphenylenes (n = 10, 8 and 9) and fullerene C₆₀: from single- to three-potential well.

    Science.gov (United States)

    Yuan, Kun; Zhou, Cai-Hua; Zhu, Yuan-Cheng; Zhao, Xiang

    2015-07-28

    The nanoscale host-guest interactions between [n]cycloparaphenylene ([n]CPP; n = 10, 8 and 9) nano-ring and fullerene C60 were explored theoretically. It is found that relatively small variations in the sizes of the [n]CPP host lead to very significant changes in encapsulation property toward the fullerene C60 guest. Expectedly, one stable inclusion-configuration of [10]CPP⊃C60 and one floating-configuration of [8]CPP⊃C60 are located on the potential surfaces of the two complexes, respectively. Unexpectedly, besides a floating-configuration (F-[9]CPP⊃C60), another stable inclusion-configuration (I-[9]CPP⊃C60) is also located on the potential surface of [9]CPP⊃C60 host-guest complex. Interaction energies and natural steric analysis show that these complexes are stabilized by balancing concave-convex π-π attractive and steric repulsive host-guest interactions. In contrast, the steric repulsive energy (Es) between host and guest of I-[9]CPP⊃C60 is as high as 233.12 kJ mol(-1), which is much larger than those in other complexes. The movements of C60 guest through the cavities of [n]CPP host (n = 10, 8 and 9) are simulated by calculating the energy profile, and the results interestingly reveal that the encapsulation of C60 by [10]CPP is in the manner of a single-potential well, by [8]CPP in the manner of a double-potential well, and by [9]CPP in the special manner of a three-potential well. We predict that the movement of C60 guest through the cavity of [9]CPP host should be experimentally observable owing to the relatively low energy barrier (<50 kJ mol(-1), M06-2X/6-31G(d)). Charge population analysis shows that an obvious charge transfer between host and guest takes place during the formation of I-[9]CPP⊃C60, which is different from those during the formation of [8]CPP⊃C60, [10]CPP⊃C60 and F-[9]CPP⊃C60. Additionally, the host-guest interaction regions were detected and visualized in real space based on the electron density and reduced density

  12. Adamantane-bearing benzylamines and benzylamides: novel building blocks for supramolecular systems with finely tuned binding properties towards β-cyclodextrin

    Czech Academy of Sciences Publication Activity Database

    Rouchal, M.; Matelová, A.; de Carvalho, F. P.; Bernat, R.; Grbić, D.; Kuřitka, I.; Babinský, M.; Marek, R.; Čmelík, Richard; Vícha, R.

    2013-01-01

    Roč. 25, č. 6 (2013), s. 349-361 ISSN 1061-0278 Institutional support: RVO:68081715 Keywords : host-guest system * cyclodextrins * adamantane Subject RIV: CB - Analytical Chemistry, Separation Impact factor: 2.132, year: 2013

  13. Quantitative analysis of the guest-concentration dependence of the mobility in a disordered fluorene-arylamine host-guest system in the guest-to-guest regime

    NARCIS (Netherlands)

    Nicolai, H. T.; Hof, A.J.; Lu, M.; Blom, P. W. M.; de Vries, R. J.; Coehoorn, R.

    2011-01-01

    The charge transport in a polyspirobifluorene derivative with copolymerized N,N,N',N'-tetraaryldiamino biphenyl (TAD) hole transport units is investigated as a function of the TAD content. For TAD concentrations larger than 5%, guest-to-guest transport is observed. It is demonstrated that in this

  14. Quantitative analysis of the guest-concentration dependence of the mobility in a disordered fluorene-arylamine host-guest system in the guest-to-guest regime

    NARCIS (Netherlands)

    Nicolai, H.T.; Hof, A.J.; Lu, M.; Blom, P.W.M.; Vries, R.J. de; Coehoorn, R.

    2011-01-01

    The charge transport in a polyspirobifluorene derivative with copolymerized N,N,N',N'-tetraaryldiamino biphenyl (TAD) hole transport units is investigated as a function of the TAD content. For TAD concentrations larger than 5, guest-to-guest transport is observed. It is demonstrated that in this

  15. Tuning of Magnetic Anisotropy in Hexairon(III) Rings by Host-Guest Interactions: An Investigation by High-Field Torque Magnetometry.

    Science.gov (United States)

    Cornia; Affronte; Jansen; Abbati; Gatteschi

    1999-08-01

    Full chemical control of magnetic anisotropy in hexairon(III) rings can be achieved by varying the size of the guest alkali metal ion. Dramatically different anisotropies characterize the Li(I) and Na(I) complexes of [Fe(6)(OMe)(12)(L)(6)] (L=1,3-propanedione derivatives; a schematic representation of the Li(I) complex is shown), as revealed by high-field torque magnetometry-Iron: (g), oxygen: o, carbon: o, Li(+): plus sign in circle.

  16. Flavylium network of chemical reactions in confined media: modulation of 3',4',7-trihydroxyflavilium reactions by host-guest interactions with cucurbit[7]uril.

    Science.gov (United States)

    Basílio, Nuno; Pina, Fernando

    2014-08-04

    In moderately acidic aqueous solutions, flavylium compounds undergo a pH-, and in some cases, light-dependent array of reversible chemical reactions. This network can be described as a single acid-base reaction involving a flavylium cation (acidic form) and a mixture of basic forms (quinoidal base, hemiketal and cis and trans chalcones). The apparent pK'a of the system and the relative mole fractions of the basic forms can be modulated by the interaction with cucurbit[7]uril. The system is studied by using (1) H NMR spectroscopy, UV/Vis spectroscopy, flash photolysis, and steady-state irradiation. Of all the network species, the flavylium cation possesses the highest affinity for cucurbit[7]uril. The rate of interconversion between flavylium cation and the basic species (where trans-chalcone is dominant) is approximately nine times lower inside the cucurbit[7]uril. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  17. Selective Surface Acoustic Wave-Based Organophosphorus Sensor Employing a Host-Guest Self-Assembly Monolayer of β-Cyclodextrin Derivative

    Directory of Open Access Journals (Sweden)

    Yong Pan

    2015-07-01

    Full Text Available Self-assembly and molecular imprinting technologies are very attractive technologies for the development of artificial recognition systems and provide chemical recognition based on need and not happenstance. In this paper, we employed a b-cyclodextrin derivative surface acoustic wave (SAW chemical sensor for detecting the chemical warfare agents (CWAs sarin (O-Isoprophyl methylphosphonofluoridate, GB. Using sarin acid (isoprophyl hydrogen methylphosphonate as an imprinting template, mono[6-deoxy-6-[(mercaptodecamethylenethio

  18. Enforcement of evaluation by achievement analysis system

    International Nuclear Information System (INIS)

    Konishi, Yasutoshi; Sonoyama, Minoru; Suzuki, Atsushi

    2004-02-01

    Japan Nuclear Cycle Development Institute (JNC) has developed FBR achievement analysis system by the last fiscal year and has enforced the investigation of its functional expansion. That system is based on the AHP (Analytic Hierarchy Process) to do comparative evaluation multilaterally between proposed concepts of FBR cycle or between FBR cycle and other power source systems. This fiscal year, we enforced achievement analysis for 22 cases of proposed concepts of FBR cycle and between FBR cycle and other power source systems (LWR, thermal power generation, hydraulic power generation, etc.). The evaluation items related with technical feasibility and social acceptability were included in addition to those of economy, resource utilization effectiveness, environmental burden reduction, nuclear proliferation resistance and safety. Also, we investigated social changes that could happen in our country in the future, and we drew 4 future scenarios combining likely changes, then we investigated classifications of weight that seem to be adequate under each scenario with its calculation logic. In establishing points of view or structure of evaluation, and in the process of drawing scenarios, we collected comments from experts in OR (Operations Research) field and energy field. (author)

  19. Achieving biopolymer synergy in systems chemistry.

    Science.gov (United States)

    Bai, Yushi; Chotera, Agata; Taran, Olga; Liang, Chen; Ashkenasy, Gonen; Lynn, David G

    2018-05-31

    Synthetic and materials chemistry initiatives have enabled the translation of the macromolecular functions of biology into synthetic frameworks. These explorations into alternative chemistries of life attempt to capture the versatile functionality and adaptability of biopolymers in new orthogonal scaffolds. Information storage and transfer, however, so beautifully represented in the central dogma of biology, require multiple components functioning synergistically. Over a single decade, the emerging field of systems chemistry has begun to catalyze the construction of mutualistic biopolymer networks, and this review begins with the foundational small-molecule-based dynamic chemical networks and peptide amyloid-based dynamic physical networks on which this effort builds. The approach both contextualizes the versatile approaches that have been developed to enrich chemical information in synthetic networks and highlights the properties of amyloids as potential alternative genetic elements. The successful integration of both chemical and physical networks through β-sheet assisted replication processes further informs the synergistic potential of these networks. Inspired by the cooperative synergies of nucleic acids and proteins in biology, synthetic nucleic-acid-peptide chimeras are now being explored to extend their informational content. With our growing range of synthetic capabilities, structural analyses, and simulation technologies, this foundation is radically extending the structural space that might cross the Darwinian threshold for the origins of life as well as creating an array of alternative systems capable of achieving the progressive growth of novel informational materials.

  20. Achieving Critical System Survivability Through Software Architectures

    National Research Council Canada - National Science Library

    Knight, John C; Strunk, Elisabeth A

    2006-01-01

    .... In a system with a survivability architecture, under adverse conditions such as system damage or software failures, some desirable function will be eliminated but critical services will be retained...

  1. A Blueprint for Innovation to Achieve Health System Transformation.

    Science.gov (United States)

    Snowdon, Anne W

    2017-01-01

    Global health systems are challenged by escalating costs and growing demands for care created by the demands of aging populations and rising rates of chronic illness which place unsustainable pressure on health systems to meet population health needs. To overcome these challenges, transformational change is needed to strengthen health system performance and sustainability. Innovation is widely viewed as the strategy to drive transformational change in health systems; yet to date, innovation has lacked a clearly defined focus or agenda to achieve transformation. An actionable innovation agenda is needed to achieve transformational change for health systems. The key conditions for success as an innovation strategy are examined, including clearly defined innovation objectives, key milestones, and actionable steps every system stakeholder must pursue in order to guide the innovation agenda and ultimately accelerate the transformational changes needed for a sustainable healthcare system that delivers value to populations.

  2. Achieving robust interchangeability of test assets in ATE systems

    CERN Document Server

    Oblad, R P

    1999-01-01

    This paper identities the key issues that have made if so difficult to achieve asset interchangeability. Several of the historical attempts to solve the problem of asset interchangeability are described, along with an analysis of the reasons that they did not achieve the expected results. Specific topics that are covered are SCPI, VXIplug&play, IVI, ATLAS, and Measurement Subsystems. Principles associated with the ownership of interfaces will be outlined. Finally, a set of rules and principles will be discussed that must be applied to achieve robust asset interchangeability. Robust is defined as interchangeability that can be "guaranteed" without testing all TPSs against the modified test system. (9 refs).

  3. On the Achievable Rate of Hardware-Impaired Transceiver Systems

    KAUST Repository

    Javed, Sidrah; Amin, Osama; Ikki, Salama S.; Alouini, Mohamed-Slim

    2018-01-01

    In this paper, we accurately model the transceiver hardware impairments (HWIs) of multiple-input multiple-output (MIMO) systems considering different HWI stages at transmitter and receiver. The proposed novel statistical model shows that transceiver HWIs transform the transmitted symmetric signal to asymmetric one. Moreover, it shows that the aggregate self-interference has asymmetric characteristics. Therefore, we propose improper Gaussian signaling (IGS) for transmission in order to improve the achievable rate performance. IGS is considered as a general signaling scheme which includes the proper Gaussian signaling (PGS) as a special case. Thus, IGS has additional design parameters which enable it to mitigate the HWI self-interference. As a case study, we analyze the achievable rate performance of single-input multiple-output systems with linear and selection combiner. Furthermore, we optimize the IGS statistical characteristics for interference alignment. This improves the achievable rate performance as compared to the PGS, which is validated through numerical results.

  4. On the Achievable Rate of Hardware-Impaired Transceiver Systems

    KAUST Repository

    Javed, Sidrah

    2018-01-15

    In this paper, we accurately model the transceiver hardware impairments (HWIs) of multiple-input multiple-output (MIMO) systems considering different HWI stages at transmitter and receiver. The proposed novel statistical model shows that transceiver HWIs transform the transmitted symmetric signal to asymmetric one. Moreover, it shows that the aggregate self-interference has asymmetric characteristics. Therefore, we propose improper Gaussian signaling (IGS) for transmission in order to improve the achievable rate performance. IGS is considered as a general signaling scheme which includes the proper Gaussian signaling (PGS) as a special case. Thus, IGS has additional design parameters which enable it to mitigate the HWI self-interference. As a case study, we analyze the achievable rate performance of single-input multiple-output systems with linear and selection combiner. Furthermore, we optimize the IGS statistical characteristics for interference alignment. This improves the achievable rate performance as compared to the PGS, which is validated through numerical results.

  5. Noise management to achieve superiority in quantum information systems

    Science.gov (United States)

    Nemoto, Kae; Devitt, Simon; Munro, William J.

    2017-06-01

    Quantum information systems are expected to exhibit superiority compared with their classical counterparts. This superiority arises from the quantum coherences present in these quantum systems, which are obviously absent in classical ones. To exploit such quantum coherences, it is essential to control the phase information in the quantum state. The phase is analogue in nature, rather than binary. This makes quantum information technology fundamentally different from our classical digital information technology. In this paper, we analyse error sources and illustrate how these errors must be managed for the system to achieve the required fidelity and a quantum superiority. This article is part of the themed issue 'Quantum technology for the 21st century'.

  6. New achievements in the EAST plasma control system

    Energy Technology Data Exchange (ETDEWEB)

    Yuan, Q.P., E-mail: qpyuan@ipp.ac.c [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei (China); Xiao, B.J. [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei (China); Penaflor, B.G.; Piglowski, D.A. [General Atomics, DIII-D National Fusion Facility, San Diego, CA (United States); Liu, L.Z. [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei (China); Johnson, R.D.; Walker, M.L.; Humphreys, D.A. [General Atomics, DIII-D National Fusion Facility, San Diego, CA (United States)

    2010-07-15

    In order to realize the low latency and distortion-free signal transmission between the plasma control system (PCS) and servo systems, the digital output structure configured with reflective memory board (RFM) was adopted in EAST PCS. And the enhanced performances are reported. Another achievement made in the latest EAST PCS was the implementation of density control algorithm, which controlled the line average density in either voltage or width modulation mode. The new integrated algorithm improved the precision of density calculation and control performance greatly. The details and experiment results are presented in this paper.

  7. HOW TO ACHIEVE A GRAPHIC LANGUAGE IN A SIGNAGE SYSTEM

    Directory of Open Access Journals (Sweden)

    ADÎR Victor

    2015-06-01

    Full Text Available This paper presents the importance of a signage system to inform and guide with a purpose: to make useful an activity. It is a special role of graphics to connect people to a system which has to be clear and legible. Along our researches in this field we have met various situations when graphic has solved the visible problem. Sometimes is not necessary to write about an activity, it is easy to develop a signage system to be understood by a lot of people. The main characteristic of such system is the design of a set of graphic representations which are much known all over the world. A few examples in this paper will demonstrate why is necessary to achieve a graphic language.

  8. Cryogenics system: strategy to achieve nominal performance and reliable operation

    CERN Document Server

    Bremer, J; Casas, J; Claudet, S; Delikaris, D; Delruelle, N; Ferlin, G; Fluder, C; Perin, A; Perinic, G; Pezzetti, M; Pirotte, O; Tavian, L; Wagner, U

    2012-01-01

    During the LHC operation in 2010 and 2011, the cryogenic system has achieved an availability level fulfilling the overall requirement. To reach this level, the cryogenic system has profited like many other beam-dependent systems from the reduced beam parameters. Therefore, impacts of some failures occurred during the LHC operation were mitigated by using the overcapacity margin, the existing built-in redundancy in between adjacent sector cryogenic plants and the "cannibalization" of spares on two idle cryogenic plants. These two first years of operation were also crucial to identify the weaknesses of the present cryogenic maintenance plan and new issues like SEUs. After the LS1, nominal beam parameters are expected and the mitigated measures will be less effective or not applicable at all. Consequently, a consolidation plan to improve the MTBF and the MTTR of the LHC cryogenic system is under definition. Concerning shutdown periods, the present cryogenic sectorization imposes some restrictions in the type of ...

  9. Building health research systems to achieve better health

    Directory of Open Access Journals (Sweden)

    González Block Miguel

    2006-11-01

    Full Text Available Abstract Health research systems can link knowledge generation with practical concerns to improve health and health equity. Interest in health research, and in how health research systems should best be organised, is moving up the agenda of bodies such as the World Health Organisation. Pioneering health research systems, for example those in Canada and the UK, show that progress is possible. However, radical steps are required to achieve this. Such steps should be based on evidence not anecdotes. Health Research Policy and Systems (HARPS provides a vehicle for the publication of research, and informed opinion, on a range of topics related to the organisation of health research systems and the enormous benefits that can be achieved. Following the Mexico ministerial summit on health research, WHO has been identifying ways in which it could itself improve the use of research evidence. The results from this activity are soon to be published as a series of articles in HARPS. This editorial provides an account of some of these recent key developments in health research systems but places them in the context of a distinguished tradition of debate about the role of science in society. It also identifies some of the main issues on which 'research on health research' has already been conducted and published, in some cases in HARPS. Finding and retaining adequate financial and human resources to conduct health research is a major problem, especially in low and middle income countries where the need is often greatest. Research ethics and agenda-setting that responds to the demands of the public are issues of growing concern. Innovative and collaborative ways are being found to organise the conduct and utilisation of research so as to inform policy, and improve health and health equity. This is crucial, not least to achieve the health-related Millennium Development Goals. But much more progress is needed. The editorial ends by listing a wide range of topics

  10. Noise management to achieve superiority in quantum information systems.

    Science.gov (United States)

    Nemoto, Kae; Devitt, Simon; Munro, William J

    2017-08-06

    Quantum information systems are expected to exhibit superiority compared with their classical counterparts. This superiority arises from the quantum coherences present in these quantum systems, which are obviously absent in classical ones. To exploit such quantum coherences, it is essential to control the phase information in the quantum state. The phase is analogue in nature, rather than binary. This makes quantum information technology fundamentally different from our classical digital information technology. In this paper, we analyse error sources and illustrate how these errors must be managed for the system to achieve the required fidelity and a quantum superiority.This article is part of the themed issue 'Quantum technology for the 21st century'. © 2017 The Author(s).

  11. Design principles for achieving integrated healthcare information systems.

    Science.gov (United States)

    Jensen, Tina Blegind

    2013-03-01

    Achieving integrated healthcare information systems has become a common goal for many countries in their pursuit of obtaining coordinated and comprehensive healthcare services. This article focuses on how a small local project termed 'Standardized pull of patient data' expanded and is now used on a large scale providing a majority of hospitals, general practitioners and citizens across Denmark with the possibility of accessing healthcare data from different electronic patient record systems and other systems. I build on design theory for information infrastructures, as presented by Hanseth and Lyytinen, to examine the design principles that facilitated this smallscale project to expand and become widespread. As a result of my findings, I outline three lessons learned that emphasize: (i) principles of flexibility, (ii) expansion from the installed base through modular strategies and (iii) identification of key healthcare actors to provide them with immediate benefits.

  12. Host-guest interaction on Bruny and Magnetic Islands, Australia

    OpenAIRE

    Moyle, Brent Don

    2017-01-01

    Islands are integral to the earth’s biodiversity, with their distinct environments offering a haven for a variety of threatened species of plants, wildlife and unique human cultures. Worldwide, tourism activity profoundly impacts upon destinations, but the impacts on islands are noticeably more acute due to their fragile environments and isolated communities. Research has found that tourism can impact island communities in a variety of ways, including economically, socially and environmentall...

  13. Host-guest supramolecular nanosystems for cancer diagnostics and therapeutics.

    Science.gov (United States)

    Wang, Lei; Li, Li-li; Fan, Yun-shan; Wang, Hao

    2013-07-26

    Extensive efforts have been devoted to the construction of functional supramolecular nanosystems for applications in catalysis, energy conversion, sensing and biomedicine. The applications of supramolecular nanosystems such as liposomes, micelles, inorganic nanoparticles, carbon materials for cancer diagnostics and therapeutics have been reviewed by other groups. Here, we will focus on the recent momentous advances in the implementation of typical supramolecular hosts (i.e., cyclodextrins, calixarenes, cucurbiturils and metallo-hosts) and their nanosystems in cancer diagnostics and therapeutics. We discuss the evolutive process of supramolecular nanosystems from the structural control and characterization to their diagnostic and therapeutic function exploitation and even the future potentials for clinical translation. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  14. SANS contrast variation on a dendrimer host-guest complex

    NARCIS (Netherlands)

    Kleppinger, R.; Mortensen, K.; Meijer, E.W.

    2002-01-01

    Small-angle neutron scattering (SANS) technique was used to study the configurational changes in an oligoethyleneoxy-functionalized poly(propyleneimine) dendrimer (host) when forming complexes with rose bengal (guest). Guinier fits to the scattering data recorded at max. contrast indicated a

  15. Cryogenics system: strategy to achieve nominal performance and reliable operation

    International Nuclear Information System (INIS)

    Bremer, J.; Brodzinski, K.; Casas, J.; Claudet, S.; Delikaris, D.; Delruelle, N.; Ferlin, G.; Fluder, C.; Perin, A.; Perinic, G.; Pezzetti, M.; Pirotte, O.; Tavian, L.; Wagner, U.

    2012-01-01

    During the LHC operation in 2010 and 2011, the cryogenic system has achieved an availability level fulfilling the overall requirement. To reach this level, the cryogenic system has profited like many other beam-dependent systems from the reduced beam parameters. Therefore, impacts of some failures occurred during the LHC operation were mitigated by using the over-capacity margin, the existing built-in redundancy in between adjacent sector cryogenic plants and the 'cannibalization' of spares on two idle cryogenic plants. These two first years of operation were also crucial to identify the weaknesses of the present cryogenic maintenance plan and new issues like SEUs. After the LS1, nominal beam parameters are expected and the mitigated measures will be less effective or not applicable at all. Consequently, a consolidation plan to improve the MTBF and the MTTR of the LHC cryogenic system is under definition. Concerning shutdown periods, the present cryogenic sectorization imposes some restrictions in the type of interventions (e.g. cryo-magnet removal) which can be done without affecting the operating conditions of the adjacent sector. This creates additional constrains and possible extra down-time in the schedule of the shutdowns including the hardware commissioning. This presentation focuses on the consolidation plan foreseen during the LS1 to improve the performance of the LHC cryogenic system in terms of availability and sectorization. (authors)

  16. The achievement and assessment of safety in systems containing software

    International Nuclear Information System (INIS)

    Ball, A.; Dale, C.J.; Butterfield, M.H.

    1986-01-01

    In order to establish confidence in the safe operation of a reactor protection system, there is a need to establish, as far as it is possible, that: (i) the algorithms used are correct; (ii) the system is a correct implementation of the algorithms; and (iii) the hardware is sufficiently reliable. This paper concentrates principally on the second of these, as it applies to the software aspect of the more accurate and complex trip functions to be performed by modern reactor protection systems. In order to engineer safety into software, there is a need to use a development strategy which will stand a high chance of achieving a correct implementation of the trip algorithms. This paper describes three broad methodologies by which it is possible to enhance the integrity of software: fault avoidance, fault tolerance and fault removal. Fault avoidance is concerned with making the software as fault free as possible by appropriate choice of specification, design and implementation methods. A fault tolerant strategy may be advisable in many safety critical applications, in order to guard against residual faults present in the software of the installed system. Fault detection and removal techniques are used to remove as many faults as possible of those introduced during software development. The paper also discusses safety and reliability assessment as it applies to software, outlining the various approaches available. Finally, there is an outline of a research project underway in the UKAEA which is intended to assess methods for developing and testing safety and protection systems involving software. (author)

  17. Intelligent and Adaptive Educational-Learning Systems Achievements and Trends

    CERN Document Server

    2013-01-01

    The Smart Innovation, Systems and Technologies book series encompasses the topics of knowledge, intelligence, innovation and sustainability. The aim of the series is to make available a platform for the publication of books on all aspects of single and multi-disciplinary research on these themes in order to make the latest results available in a readily-accessible form.  This book is devoted to the “Intelligent and Adaptive Educational-Learning Systems”. It privileges works that highlight key achievements and outline trends to inspire future research.  After a rigorous revision process twenty manuscripts were accepted and organized into four parts as follows: ·     Modeling: The first part embraces five chapters oriented to: 1) shape the affective behavior; 2) depict the adaptive learning curriculum; 3) predict learning achievements; 4) mine learner models to outcome optimized and adaptive e-learning objects; 5) classify learning preferences of learners. ·     Content: The second part encompas...

  18. Evaluation of Roadmap to Achieve Energy Delivery Systems Cybersecurity

    Energy Technology Data Exchange (ETDEWEB)

    Chavez, Adrian R. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2017-10-01

    The Department of Energy/Office of Electricity Delivery and Energy Reliability (DOE/OE) Cybersecurity for Energy Delivery Systems (CEDS) program is currently evaluating the Roadmap to Achieve Energy Delivery Systems Cybersecurity document that sets a vision and outlines a set of milestones. The milestones are divided into five strategic focus areas that include: 1. Build a Culture of Security; 2. Assess and Monitor Risk; 3. Develop and Implement New Protective Measures to Reduce Risk; 4. Manage Incidents; and 5. Sustain Security Improvements. The most current version of the roadmap was last updated in September of 2016. Sandia National Laboratories (SNL) has been tasked with revisiting the roadmap to update the current state of energy delivery systems cybersecurity protections. SNL is currently working with previous and current partners to provide feedback on which of the roadmap milestones have been met and to identify any preexisting or new gaps that are not addressed by the roadmap. The specific focus areas SNL was asked to evaluate are: 1. Develop and Implement New Protective Measures to Reduce Risk and 2. Sustain Security Improvements. SNL has formed an Industry Advisory Board (IAB) to assist in answering these questions. The IAB consists of previous partners on past CEDS funded efforts as well as new collaborators that have unique insights into the current state of cybersecurity within energy delivery systems. The IAB includes asset owners, utilities and vendors of control systems. SNL will continue to maintain regular communications with the IAB to provide various perspectives on potential future updates to further improve the breadth of cybersecurity coverage of the roadmap.

  19. Supramolecular Drug Delivery Systems Based on Water-Soluble Pillar[n]arenes.

    Science.gov (United States)

    Wu, Xuan; Gao, Lei; Hu, Xiao-Yu; Wang, Leyong

    2016-06-01

    Supramolecular drug delivery systems (SDDSs), including various kinds of nanostructures that are assembled by reversible noncovalent interactions, have attracted considerable attention as ideal drug carriers owing to their fascinating ability to undergo dynamic switching of structure, morphology, and function in response to various external stimuli, which provides a flexible and robust platform for designing and developing functional and smart supramolecular nano-drug carriers. Pillar[n]arenes represent a new generation of macrocyclic hosts, which have unique structures and excellent properties in host-guest chemistry. This account describes recent progress in our group to develop pillararene-based stimuli-responsive supramolecular nanostructures constructed by reversible host-guest interactions for controllable anticancer drug delivery. The potential applications of these supramolecular drug carriers in cancer treatment and the fundamental questions facing SDDSs are also discussed. © 2016 The Chemical Society of Japan & Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  20. The Organic Foods System: Its Discursive Achievements and Prospects

    Science.gov (United States)

    Nowacek, David M.; Nowacek, Rebecca S.

    2008-01-01

    Taking the emergence of the organic foods system as a case study, the authors aim to demonstrate both how the discursive richness of the organic foods system offers a challenge to the traditional operations of the market and how activity systems theory as understood in English studies can productively be tied to and enriched by theories of social…

  1. Achieving Quality Assurance in Nigeria University System through ...

    African Journals Online (AJOL)

    This paper examines how quality assurance can be attained through Strategic Human Resources Development in Nigerian University system. The purpose is to ensure quality control and maintenance of acceptable standards in the University system. To seek solution to the problem, three research questions were posed.

  2. COBRA System Engineering Processes to Achieve SLI Strategic Goals

    Science.gov (United States)

    Ballard, Richard O.

    2003-01-01

    The COBRA Prototype Main Engine Development Project was an endeavor conducted as a joint venture between Pratt & Whitney and Aerojet to conduct risk reduction in LOX/LH2 main engine technology for the NASA Space Launch Initiative (SLI). During the seventeen months of the project (April 2001 to September 2002), approximately seventy reviews were conducted, beginning with the Engine Systems Requirements Review (SRR) and ending with the Engine Systems Interim Design Review (IDR). This paper discusses some of the system engineering practices used to support the reviews and the overall engine development effort.

  3. Finding a Roadmap to achieve Large Neuromorphic Hardware Systems

    Directory of Open Access Journals (Sweden)

    Jennifer eHasler

    2013-09-01

    Full Text Available Neuromorphic systems are gaining increasing importance in an era where CMOS digital computing techniques are meeting hard physical limits. These silicon systems mimic extremely energy efficient neural computing structures, potentially both for solving engineering applications as well as understanding neural computation. Towards this end, the authors provide a glimpse at what the technology evolution roadmap looks like for these systems so that Neuromorphic engineers may gain the same benefit of anticipation and foresight that IC designers gained from Moore's law many years ago. Scaling of energy efficiency, performance, and size will be discussed as well as how the implementation and application space of Neuromorphic systems are expected to evolve over time.

  4. MyOcean Information System : achievements and perspectives

    Science.gov (United States)

    Loubrieu, T.; Dorandeu, J.; Claverie, V.; Cordier, K.; Barzic, Y.; Lauret, O.; Jolibois, T.; Blower, J.

    2012-04-01

    MyOcean system (http://www.myocean.eu) objective is to provide a Core Service for the Ocean. This means MyOcean is setting up an operational service for forecasts, analysis and expertise on ocean currents, temperature, salinity, sea level, primary ecosystems and ice coverage. The production of observation and forecasting data is distributed through 12 production centres. The interface with the external users (including web portal) and the coordination of the overall service is managed by a component called service desk. Besides, a transverse component called MIS (myOcean Information System) aims at connecting the production centres and service desk together, manage the shared information for the overall system and implement a standard Inspire interface for the external world. 2012 is a key year for the system. The MyOcean, 3-year project, which has set up the first versions of the system is ending. The MyOcean II, 2-year project, which will upgrade and consolidate the system is starting. Both projects are granted by the European commission within the GMES Program (7th Framework Program). At the end of the MyOcean project, the system has been designed and the 2 first versions have been implemented. The system now offers an integrated service composed with 237 ocean products. The ocean products are homogeneously described in a catalogue. They can be visualized and downloaded by the user (identified with a unique login) through a seamless web interface. The discovery and viewing interfaces are INSPIRE compliant. The data production, subsystems availability and audience are continuously monitored. The presentation will detail the implemented information system architecture and the chosen software solutions. Regarding the information system, MyOcean II is mainly aiming at consolidating the existing functions and promoting the operations cost-effectiveness. In addition, a specific effort will be done so that the less common data features of the system (ocean in

  5. CRISPR technologies for bacterial systems: Current achievements and future directions

    DEFF Research Database (Denmark)

    Choi, Kyeong Rok; Lee, Sang Yup

    2016-01-01

    Throughout the decades of its history, the advances in bacteria-based bio-industries have coincided with great leaps in strain engineering technologies. Recently unveiled clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated proteins (Cas) systems are now revolution......Throughout the decades of its history, the advances in bacteria-based bio-industries have coincided with great leaps in strain engineering technologies. Recently unveiled clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated proteins (Cas) systems are now...... revolutionizing biotechnology as well as biology. Diverse technologies have been derived from CRISPR/Cas systems in bacteria, yet the applications unfortunately have not been actively employed in bacteria as extensively as in eukaryotic organisms. A recent trend of engineering less explored strains in industrial...... microbiology-metabolic engineering, synthetic biology, and other related disciplines-is demanding facile yet robust tools, and various CRISPR technologies have potential to cater to the demands. Here, we briefly review the science in CRISPR/Cas systems and the milestone inventions that enabled numerous CRISPR...

  6. CRISPR technologies for bacterial systems: Current achievements and future directions.

    Science.gov (United States)

    Choi, Kyeong Rok; Lee, Sang Yup

    2016-11-15

    Throughout the decades of its history, the advances in bacteria-based bio-industries have coincided with great leaps in strain engineering technologies. Recently unveiled clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated proteins (Cas) systems are now revolutionizing biotechnology as well as biology. Diverse technologies have been derived from CRISPR/Cas systems in bacteria, yet the applications unfortunately have not been actively employed in bacteria as extensively as in eukaryotic organisms. A recent trend of engineering less explored strains in industrial microbiology-metabolic engineering, synthetic biology, and other related disciplines-is demanding facile yet robust tools, and various CRISPR technologies have potential to cater to the demands. Here, we briefly review the science in CRISPR/Cas systems and the milestone inventions that enabled numerous CRISPR technologies. Next, we describe CRISPR/Cas-derived technologies for bacterial strain development, including genome editing and gene expression regulation applications. Then, other CRISPR technologies possessing great potential for industrial applications are described, including typing and tracking of bacterial strains, virome identification, vaccination of bacteria, and advanced antimicrobial approaches. For each application, we note our suggestions for additional improvements as well. In the same context, replication of CRISPR/Cas-based chromosome imaging technologies developed originally in eukaryotic systems is introduced with its potential impact on studying bacterial chromosomal dynamics. Also, the current patent status of CRISPR technologies is reviewed. Finally, we provide some insights to the future of CRISPR technologies for bacterial systems by proposing complementary techniques to be developed for the use of CRISPR technologies in even wider range of applications. Copyright © 2016. Published by Elsevier Inc.

  7. Controlling open quantum systems: tools, achievements, and limitations

    International Nuclear Information System (INIS)

    Koch, Christiane P

    2016-01-01

    The advent of quantum devices, which exploit the two essential elements of quantum physics, coherence and entanglement, has sparked renewed interest in the control of open quantum systems. Successful implementations face the challenge of preserving relevant nonclassical features at the level of device operation. A major obstacle is decoherence, which is caused by interaction with the environment. Optimal control theory is a tool that can be used to identify control strategies in the presence of decoherence. Here we review recent advances in optimal control methodology that allow typical tasks in device operation for open quantum systems to be tackled and discuss examples of relaxation-optimized dynamics. Optimal control theory is also a useful tool to exploit the environment for control. We discuss examples and point out possible future extensions. (topical review)

  8. Controlling open quantum systems: Tools, achievements, and limitations

    OpenAIRE

    Koch, Christiane P.

    2016-01-01

    The advent of quantum devices, which exploit the two essential elements of quantum physics, coherence and entanglement, has sparked renewed interest in the control of open quantum systems. Successful implementations face the challenge to preserve the relevant nonclassical features at the level of device operation. A major obstacle is decoherence which is caused by interaction with the environment. Optimal control theory is a tool that can be used to identify control strategies in the presence...

  9. THE EUROPEAN BANKING SYSTEM. TRACK RECORD AND ACHIEVEMENT

    Directory of Open Access Journals (Sweden)

    ADELA IONESCU

    2014-11-01

    Full Text Available The banking system of Europe has experienced two decades of turbulence. Through the 1990’s a wave of mergers, liquidations and bankruptcies has swept the sector. This wave was at its peak the last years of the 1990’s and the 2000-2004 period. Since then the number of exits from the sector has been relatively stable. It is notable that the cooperative banks suffered more than the commercials. This fact can be attributed to their smaller size, ownership structure, management efficiency etc.During the last decade a great number of events have forced the banking system in Europe to transform, to adapt to a new financial, economic, political and social environment. Two financial crisis (2001-2002 and 2008-2009, two voluntary attempts to regulate the financial system (Basel II and III, the introduction of the Euro and the establishment of the European Central Bank, several regulation attempts to create an isomorphic legal environment, financial scandals of 2001-2002, 2008 and the globalization of the financial sector are some of the events that created a new environment for the financial sector.

  10. Information System Specific in Achievement of Construction Projects

    Directory of Open Access Journals (Sweden)

    Cătălin Onuţu

    2005-01-01

    Full Text Available Because of the economic changes from our country and also of the rapid adjusting necessity to the requirement of a market economy, it is observed a huge request for information, and especially techniques, tools, methodologies that would facilitate the managerial activity in any field. In the construction field the problem is even more serious because of specific aspects and of the traditional information system that is very stiff. Formal and bureaucratic, and this makes the adjusting process of specialist to the economic realities to be more difficult.

  11. Achieving Optimal Privacy in Trust-Aware Social Recommender Systems

    Science.gov (United States)

    Dokoohaki, Nima; Kaleli, Cihan; Polat, Huseyin; Matskin, Mihhail

    Collaborative filtering (CF) recommenders are subject to numerous shortcomings such as centralized processing, vulnerability to shilling attacks, and most important of all privacy. To overcome these obstacles, researchers proposed for utilization of interpersonal trust between users, to alleviate many of these crucial shortcomings. Till now, attention has been mainly paid to strong points about trust-aware recommenders such as alleviating profile sparsity or calculation cost efficiency, while least attention has been paid on investigating the notion of privacy surrounding the disclosure of individual ratings and most importantly protection of trust computation across social networks forming the backbone of these systems. To contribute to addressing problem of privacy in trust-aware recommenders, within this paper, first we introduce a framework for enabling privacy-preserving trust-aware recommendation generation. While trust mechanism aims at elevating recommender's accuracy, to preserve privacy, accuracy of the system needs to be decreased. Since within this context, privacy and accuracy are conflicting goals we show that a Pareto set can be found as an optimal setting for both privacy-preserving and trust-enabling mechanisms. We show that this Pareto set, when used as the configuration for measuring the accuracy of base collaborative filtering engine, yields an optimized tradeoff between conflicting goals of privacy and accuracy. We prove this concept along with applicability of our framework by experimenting with accuracy and privacy factors, and we show through experiment how such optimal set can be inferred.

  12. MyOcean Central Information System - Achievements and Perspectives

    Science.gov (United States)

    Claverie, Vincent; Loubrieu, Thomas; Jolibois, Tony; de Dianous, Rémi; Blower, Jon; Romero, Laia; Griffiths, Guy

    2013-04-01

    Since 2009, MyOcean (http://www.myocean.eu) is providing an operational service, for forecasts, analysis and expertise on ocean currents, temperature, salinity, sea level, primary ecosystems and ice coverage. The production of observation and forecasting data is done by 42 Production Units (PU). Product download and visualisation are hosted by 25 Dissemination Units (DU). All these products and associated services are gathered in a single catalogue hiding the intricate distributed organization of PUs and DUs. Besides applying INSPIRE directive and OGC recommendations, MyOcean overcomes technical choices and challenges. This presentation focuses on 3 specific issues met by MyOcean and relevant for many Spatial Data Infrastructures: user's transaction accounting, large volume download and stream line the catalogue maintenance. Transaction Accounting: Set up powerful means to get detailed knowledge of system usage in order to subsequently improve the products (ocean observations, analysis and forecast dataset) and services (view, download) offer. This subject drives the following ones: Central authentication management for the distributed web services implementations: add-on to THREDDS Data Server for WMS and NETCDF sub-setting service, specific FTP. Share user management with co-funding projects. In addition to MyOcean, alternate projects also need consolidated information about the use of the cofunded products. Provide a central facility for the user management. This central facility provides users' rights to geographically distributed services and gathers transaction accounting history from these distributed services. Propose a user-friendly web interface to download large volume of data (several GigaBytes) as robust as basic FTP but intuitive and file/directory independent. This should rely on a web service drafting the INSPIRE to-be specification and OGC recommendations for download taking into account that FTP server is not enough friendly (need to know

  13. The Empathizing-Systemizing Theory, Social Abilities, and Mathematical Achievement in Children.

    Science.gov (United States)

    Escovar, Emily; Rosenberg-Lee, Miriam; Uddin, Lucina Q; Menon, Vinod

    2016-03-14

    The Empathizing-Systemizing (E-S) theory describes a profile of traits that have been linked to autism spectrum disorders, and are thought to encompass a continuum that includes typically developing (TD) individuals. Although systemizing is hypothesized to be related to mathematical abilities, empirical support for this relationship is lacking. We examine the link between empathizing and systemizing tendencies and mathematical achievement in 112 TD children (57 girls) to elucidate how socio-cognitive constructs influence early development of mathematical skills. Assessment of mathematical achievement included standardized tests designed to examine calculation skills and conceptual mathematical reasoning. Empathizing and systemizing were assessed using the Combined Empathy Quotient-Child (EQ-C) and Systemizing Quotient-Child (SQ-C). Contrary to our hypothesis, we found that mathematical achievement was not related to systemizing or the discrepancy between systemizing and empathizing. Surprisingly, children with higher empathy demonstrated lower calculation skills. Further analysis using the Social Responsiveness Scale (SRS) revealed that the relationship between EQ-C and mathematical achievement was mediated by social ability rather than autistic behaviors. Finally, social awareness was found to play a differential role in mediating the relationship between EQ-C and mathematical achievement in girls. These results identify empathy, and social skills more generally, as previously unknown predictors of mathematical achievement.

  14. Achievable capacity of a spectrum sharing system over hyper fading channels

    KAUST Repository

    Ekin, Sabit; Yilmaz, Ferkan; Ç elebi, Hasari Burak; Qaraqe, Khalid A.; Alouini, Mohamed-Slim; Serpedin, Erchin

    2009-01-01

    Cognitive radio with spectrum sharing feature is a promising technique to address the spectrum under-utilization problem in dynamically changing environments. In this paper, achievable capacity gain of spectrum sharing systems over dynamic fading

  15. Achievements and Problems of Reform of Investment Management System for Shanghai Pilot Free Trade Zone

    Institute of Scientific and Technical Information of China (English)

    Chengrong; PAN

    2014-01-01

    The establishment of Shanghai Pilot Free Trade Zone provides many possibilities for China’s economic construction. This paper made a comparative analysis on investment management system of Shanghai Pilot Free Trade Zone and traditional investment management system,discussed achievements and problems of reform of investment management system of Shanghai Pilot Free Trade Zone,and finally came up with pertinent policy recommendations.

  16. Experimental Study of Nuclear Security System Components for Achieving the Intrusion Process via Sensor's Network System

    International Nuclear Information System (INIS)

    EL-Kafas, A.A.

    2011-01-01

    Cluster sensors are one of nuclear security system components which are used to detect any intrusion process of the nuclear sites. In this work, an experimental measuring test for sensor performance and procedures are presented. Sensor performance testing performed to determine whether a particular sensor will be acceptable in a proposed design. We have access to a sensors test field in which the sensor of interest is already properly installed and the parameters have been set to optimal levels by preliminary testing. The glass-breakage (G.B) and open door (O.D) sensors construction, operation and design for the investigated nuclear site are explained. Intrusion tests were carried out inside the field areas of the sensors to evaluate the sensor performance during the intrusion process. Experimental trials were performed for achieving the intrusion process via sensor network system. The performance and intrusion senses of cluster sensors inside the internal zones was recorded and evaluated. The obtained results explained that the tested and experimented G.B sensors have a probability of detection P (D) value 65% founded, and 80% P (D) of Open-door sensor

  17. The effect of multiple external representations (MERs) worksheets toward complex system reasoning achievement

    Science.gov (United States)

    Sumarno; Ibrahim, M.; Supardi, Z. A. I.

    2018-03-01

    The application of a systems approach to assessing biological systems provides hope for a coherent understanding of cell dynamics patterns and their relationship to plant life. This action required the reasoning about complex systems. In other sides, there were a lot of researchers who provided the proof about the instructional successions. They involved the multiple external representations which improved the biological learning. The researcher conducted an investigation using one shoot case study design which involved 30 students in proving that the MERs worksheets could affect the student's achievement of reasoning about complex system. The data had been collected based on test of reasoning about complex system and student's identification result who worked through MERs. The result showed that only partially students could achieve reasoning about system complex, but their MERs skill could support their reasoning ability of complex system. This study could bring a new hope to develop the MERs worksheet as a tool to facilitate the reasoning about complex system.

  18. Achievement report for fiscal 1998. Optical tomographic system; 1998 nendo seika hokokusho. Hikari danso imaging system

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-05-01

    Evaluations were given on spatial resolution and measurement time of an optical tomographic system by using the developed 64-channel time-resolved spectroscopy and an image reconstruction algorithm. With respect to the spatial resolution, the target value of 1 cm was verified from tomographic images of a phantom with a diameter of 10cm, simulating a neonate. The measurement time achieved 20 minutes, being one third of the target value. In installing the equipment at Hokkaido University, speeds of the optical switches and attenuators were increased to have reduced the measurement time to one minute. For installation at Kanagawa Rehabilitation Center, development has been made on a nano-second light pulser, whose average beam quantity has been increased to 40 times, and improvement has been given on the optical switches, the attenuators, and the indication software, by which the measurement time was decreased further by 30 seconds than that at Hokkaido University. In performing the clinical evaluation, the evaluation protocol resolved by the Experiment Evaluation Special Committee was submitted for deliberation at the Medical Welfare Device Clinical Evaluation Committee. Upon having been authorized by the Committee, the clinical evaluations were performed at Hokkaido University and the Kanagawa Rehabilitation Center. (NEDO)

  19. Achievable capacity of a spectrum sharing system over hyper fading channels

    KAUST Repository

    Ekin, Sabit

    2009-11-01

    Cognitive radio with spectrum sharing feature is a promising technique to address the spectrum under-utilization problem in dynamically changing environments. In this paper, achievable capacity gain of spectrum sharing systems over dynamic fading environments is studied. For the analysis, a theoretical fading model called hyper fading model that is suitable to the dynamic nature of cognitive radio channel is proposed. Closed-form expression of probability density function (PDF) and cumulative density function (CDF) of the signal-to-noise ratio (SNR) for secondary users in spectrum sharing systems are derived. In addition, the capacity gains achievable with spectrum sharing systems in high and low power regions are obtained. Numerical simulations are performed to study the effects of different fading figures, average powers, interference temperature, and number of secondary users on the achievable capacity.

  20. Achievements and Problems of Reform of Investment Management System for Shanghai Pilot Free Trade Zone

    OpenAIRE

    PAN, Chengrong

    2014-01-01

    The establishment of Shanghai Pilot Free Trade Zone provides many possibilities for China’s economic construction. This paper made a comparative analysis on investment management system of Shanghai Pilot Free Trade Zone and traditional investment management system, discussed achievements and problems of reform of investment management system of Shanghai Pilot Free Trade Zone, and finally came up with pertinent policy recommendations.

  1. Experimental analysis on a novel solar collector system achieved by supercritical CO2 natural convection

    International Nuclear Information System (INIS)

    Chen, Lin; Zhang, Xin-Rong

    2014-01-01

    Highlights: • Supercritical CO 2 flow is proposed for natural circulation solar water heater system. • Experimental system established and consists of supercritical fluid high pressure side and water side. • Stable supercritical CO 2 natural convective flow is well induced and water heating process achieved. • Seasonal solar collector system efficiency above 60% achieved and optimization discussed. - Abstract: Solar collector has become a hot topic both in scientific research and engineering applications. Among the various applications, the hot water supply demand accounts for a large part of social energy consumption and has become one promising field. The present study deals with a novel solar thermal conversion and water heater system achieved by supercritical CO 2 natural circulation. Experimental systems are established and tested in Zhejiang Province (around N 30.0°, E 120.6°) of southeast China. The current system is designed to operate in the supercritical region, thus the system can be compactly made and achieve smooth high rate natural convective flow. During the tests, supercritical CO 2 pipe flow with Reynolds number higher than 6700 is found. The CO 2 fluid temperature in the heat exchanger can be as high as 80 °C and a stable supply of hot water above 45 °C is achieved. In the seasonal tests, relative high collector efficiency generally above 60.0% is obtained. Thermal and performance analysis is carried out with the experiment data. Comparisons between the present system and previous solar water heaters are also made in this paper

  2. A comparative study of compression-expansion type dehumidification systems to achieve low dew point air

    International Nuclear Information System (INIS)

    Moon, Choon; Bansal, Pradeep

    2009-01-01

    This paper presents a theoretical feasibility study of three dehumidification systems to achieve air with dew points down to (-) 40 deg. C. The systems consist of compressors, heat exchangers, expanders and heaters. A thermodynamic model has been developed of the systems to study the effect of the compressor, expander, and heat recovery heat exchanger efficiency as a function of pressure ratio, net required work, quantity of condensed moisture, and system outlet dew point temperature. The analysis has revealed that the selection of a heat recovery heat exchanger is critical for an efficient dehumidification system, where compressor efficiency has the dominant effect on power consumption.

  3. 3D Game-Based Learning System for Improving Learning Achievement in Software Engineering Curriculum

    Science.gov (United States)

    Su,Chung-Ho; Cheng, Ching-Hsue

    2013-01-01

    The advancement of game-based learning has encouraged many related studies, such that students could better learn curriculum by 3-dimension virtual reality. To enhance software engineering learning, this paper develops a 3D game-based learning system to assist teaching and assess the students' motivation, satisfaction and learning achievement. A…

  4. Problem-Based Learning in Communication Systems: Student Perceptions and Achievement

    Science.gov (United States)

    Mitchell, John E.; Canavan, Brian; Smith, Jan

    2010-01-01

    The paper presents a curriculum design for, and subsequent evaluation of, a communications systems course using problem-based learning (PBL) as the instructional methodology. It details the rationale for implementing PBL as well as reporting intended learning outcomes and assessing the students' achievements. (Contains 2 figures and 4 tables.)

  5. A Mobile Gamification Learning System for Improving the Learning Motivation and Achievements

    Science.gov (United States)

    Su, C-H.; Cheng, C-H.

    2015-01-01

    This paper aims to investigate how a gamified learning approach influences science learning, achievement and motivation, through a context-aware mobile learning environment, and explains the effects on motivation and student learning. A series of gamified learning activities, based on MGLS (Mobile Gamification Learning System), was developed and…

  6. The Effects of the Classroom Performance System on Student Participation, Attendance, and Achievement

    Science.gov (United States)

    Termos, Mohamad Hani

    2013-01-01

    The Classroom Performance System (CPS) is an instructional technology that increases student performance and promotes active learning. This study assessed the effect of the CPS on student participation, attendance, and achievement in multicultural college-level anatomy and physiology classes, where students' first spoken language is not English.…

  7. Achievable rate of spectrum sharing cognitive radio systems over fading channels at low-power regime

    KAUST Repository

    Sboui, Lokman

    2014-11-01

    We study the achievable rate of cognitive radio (CR) spectrum sharing systems at the low-power regime for general fading channels and then for Nakagami fading. We formally define the low-power regime and present the corresponding closed-form expressions of the achievable rate lower bound under various types of interference and/or power constraints, depending on the available channel state information of the cross link (CL) between the secondary-user transmitter and the primary-user receiver. We explicitly characterize two regimes where either the interference constraint or the power constraint dictates the optimal power profile. Our framework also highlights the effects of different fading parameters on the secondary link (SL) ergodic achievable rate. We also study more realistic scenarios when there is either 1-bit quantized channel feedback from the CL alone or 2-bit feedback from both the CL and the SL and propose simple power control schemes and show that these schemes achieve the previously achieved rate at the low-power regime. Interestingly, we show that the low-power regime analysis provides a specific insight into the maximum achievable rate behavior of CR that has not been reported by previous studies.

  8. Development of brain systems for nonsymbolic numerosity and the relationship to formal math academic achievement.

    Science.gov (United States)

    Haist, Frank; Wazny, Jarnet H; Toomarian, Elizabeth; Adamo, Maha

    2015-02-01

    A central question in cognitive and educational neuroscience is whether brain operations supporting nonlinguistic intuitive number sense (numerosity) predict individual acquisition and academic achievement for symbolic or "formal" math knowledge. Here, we conducted a developmental functional magnetic resonance imaging (MRI) study of nonsymbolic numerosity task performance in 44 participants including 14 school age children (6-12 years old), 14 adolescents (13-17 years old), and 16 adults and compared a brain activity measure of numerosity precision to scores from the Woodcock-Johnson III Broad Math index of math academic achievement. Accuracy and reaction time from the numerosity task did not reliably predict formal math achievement. We found a significant positive developmental trend for improved numerosity precision in the parietal cortex and intraparietal sulcus specifically. Controlling for age and overall cognitive ability, we found a reliable positive relationship between individual math achievement scores and parietal lobe activity only in children. In addition, children showed robust positive relationships between math achievement and numerosity precision within ventral stream processing areas bilaterally. The pattern of results suggests a dynamic developmental trajectory for visual discrimination strategies that predict the acquisition of formal math knowledge. In adults, the efficiency of visual discrimination marked by numerosity acuity in ventral occipital-temporal cortex and hippocampus differentiated individuals with better or worse formal math achievement, respectively. Overall, these results suggest that two different brain systems for nonsymbolic numerosity acuity may contribute to individual differences in math achievement and that the contribution of these systems differs across development. © 2014 Wiley Periodicals, Inc.

  9. The Best Achievable ℋ2 Tracking Performances for SIMO Feedback Control Systems

    Directory of Open Access Journals (Sweden)

    Shinji Hara

    2007-01-01

    Full Text Available This paper is concerned with the inherent ℋ2 tracking performance limitation of single-input and multiple-output (SIMO linear time-invariant (LTI feedback control systems. The performance is measured by the tracking error between a step reference input and the plant output with additional penalty on control input. We employ the plant augmentation strategy, which enables us to derive analytical closed-form expressions of the best achievable performance not only for discrete-time system, but also for continuous-time system by exploiting the delta domain version of the expressions.

  10. Effective Consultants: A Conceptual Framework for Helping School Systems Achieve Systemic Reform

    Science.gov (United States)

    Hazle Bussey, Leslie; Welch, Jennie C.; Mohammed, Meca B.

    2014-01-01

    A growing number of organisations--universities, non-profits, independent consultants--are emerging as partners to school systems pursuing systemic improvement. This proliferation invites questions probing the interaction between school systems and their consulting partners. Drawing on a cross-disciplinary review of literature, this theoretical…

  11. A study on the achievable data rate in massive MIMO system

    Science.gov (United States)

    Salh, Adeeb; Audah, Lukman; Shah, Nor Shahida M.; Hamzah, Shipun A.

    2017-09-01

    The achievable high data rates depend on the ability of massive multi-input-multi-output (MIMO) for the fifth-generation (5G) cellular networks, where the massive MIMO systems can support very high energy and spectral efficiencies. A major challenge in mobile broadband networks is how to support the throughput in the future 5G, where the highlight of 5G expected to provide high speed internet for every user. The performance massive MIMO system increase with linear minimum mean square error (MMSE), zero forcing (ZF) and maximum ratio transmission (MRT) when the number of antennas increases to infinity, by deriving the closed-form approximation for achievable data rate expressions. Meanwhile, the high signal-to-noise ratio (SNR) can be mitigated by using MMSE, ZF and MRT, which are used to suppress the inter-cell interference signals between neighboring cells. The achievable sum rate for MMSE is improved based on the distributed users inside cell, mitigated the inter-cell interference caused when send the same signal by other cells. By contrast, MMSE is better than ZF in perfect channel state information (CSI) for approximately 20% of the achievable sum rate.

  12. An evaluation of China's new rural cooperative medical system: achievements and inadequacies from policy goals.

    Science.gov (United States)

    Li, Chengyue; Hou, Yilin; Sun, Mei; Lu, Jun; Wang, Ying; Li, Xiaohong; Chang, Fengshui; Hao, Mo

    2015-10-23

    Although much public scrutiny and academic attention has focused on the evaluations of system implementation since the beginning of New Rural Cooperative Medical System (NRCMS) in China, few studies have systematically evaluated the achievements of the stated policy goals. The purpose of this study is to examine to what extent the policy goals of NRCMS have been achieved. Using multistage sampling processes, two rounds of cross-sectional household surveys including 9787 and 7921 rural households were conducted in Eastern China in year 2000 and year 2008, respectively. A pre- and post-implementation comparison was used to evaluate the achievement of policy goals in three measures: impoverishment from major health hazards, household financial risk from medical expenses, and rural income inequity. Intention surveys were also applied to find out potential obstacles in the implementation of NRCMS. The rate of re-impoverishment from health hazard was reduced from 2.69 % ex ante to 2.12 % ex post, a decrease of 21.13 %. The severity of impoverishment fell from a previous 4.66 % to 3.02 %, a decline of 35.18 %. Economic risk of medical treatment population relative to the whole population fell from 2.62 ex ante to 2.03 ex post, a 22.52 % reduction. As indication of effect on improving income equity, the Gini coefficient fell from 0.4629 to 0.4541. The effects of NRCMS were significantly better than those of RCMS. Despite the preliminary achievements, our intention survey of key respondents identified that technical difficulties in actuarial funding and more sustainable reimbursement schedules has become the most challenging barriers in achieving the goals of NRCMS, while raising the insurance premium on NRCMS was no longer as big a barrier. With NRCMS, China has established a medical security system to reduce the financial burden of healthcare on rural residents. NRCMS has achieved some positive though limited effects; but technical difficulties in the implementation of

  13. The Support System in Distance Education:Factors Affecting Achievements Among Women Learners

    Directory of Open Access Journals (Sweden)

    Rozhan M IDRUS

    2005-10-01

    Full Text Available The Support System in Distance Education:Factors Affecting Achievements Among Women Learners Hanafi ATAN Zuraidah A. RAHMAN Omar MAJID Noraida A. GHANIRozhan M IDRUS School of Distance EducationUniversiti Sains Malaysia11800 Penang, MALAYSIA ABSTRACT Distance education has the potential to contribute to the enhancement of women’s development by overcoming not only temporal and spatial barriers but familial commitments as well. It brings education to their home and allows women to learn at their individual pace, seek skills for individual development and at the same time, enables them to fulfill family responsibilities. An important element of distance education is the provision of the learner support system that provides students the access to learning resources and means of communication that would facilitate the array of educational activities and exposure to various other guidance and advisories. This paper reports on the study undertaken to elucidate the dimensions of the support system provided by the School of Distance Education (SDE, Universiti Sains Malaysia (USM to its women learners that would have significant impact on their achievements. The factorial analysis conducted revealed that the role of the faculty is the main contributing factor affecting these achievements, followed by the provision of the intensive course, the electronic portal, video conferencing and to a much lesser extent, the existence of the regional centres. The implications of this study are discussed with the view of improving the support system provided by the institution and the need to put into action the necessary strategies to further improve the achievement of the women learners.

  14. Achieving Closure for Bioregenerative Life Support Systems: Engineering and Ecological Challenges, Research Opportunities

    Science.gov (United States)

    Dempster, William; Allen, John P.

    Closed systems are desirable for a number of purposes: space life support systems where precious life-supporting resources need to be kept inside; biospheric systems; where global ecological pro-cesses can be studied in great detail and testbeds where research topics requiring isolation from the outside (e.g. genetically modified organisms; radioisotopes) can be studied in isolation from the outside environment and where their ecological interactions and fluxes can be studied. But to achieve and maintain closure raises both engineering and ecological challenges. Engineering challenges include methods of achieving closure for structures of different materials, and devel-oping methods of allowing energy (for heating and cooling) and information transfer through the materially closed structure. Methods of calculating degree of closure include measuring degradation rates of inert trace gases introduced into the system. An allied problem is devel-oping means of locating where leaks are located so that they may be repaired and degree of closure maintained. Once closure is achieved, methods of dealing with the pressure differen-tials between inside and outside are needed: from inflatable structures which might adjust to the pressure difference to variable volume chambers attached to the life systems component. These issues are illustrated through the engineering employed at Biosphere 2, the Biosphere 2 Test Module and the Laboratory Biosphere and a discussion of methods used by other closed ecological system facility engineers. Ecological challenges include being able to handle faster cycling rates and accentuated daily and seasonal fluxes of critical life elements such as carbon dioxide, oxygen, water, macro-and mico-nutrients. The problems of achieving sustainability in closed systems for life support include how to handle atmospheric dynamics including trace gases, producing a complete human diet and recycling nutrients and maintaining soil fertility, healthy air and

  15. INFORMATION SYSTEM DESIGN OF PERFORMANCE ACHIEVEMENTS MONITORING IN THE UNIVERSITY: A CASE STUDY IN BINUS UNIVERSITY

    Directory of Open Access Journals (Sweden)

    Irma Irawati Ibrahim

    2012-05-01

    Full Text Available Dashboard is a computer interface that displays a variety of charts, graphs, tables, which are selected reports from various data that are considered important to display rapidly, with an attractive appearance, dynamic, and relevant so that it can immediately be seen quickly to analyze a condition. Dashboard information system is widely used in various companies as a support system for decision-making where Dashboard usually displays data business trends of the company or the achievement of KPI (Key Performance Indicator of a company. The method used is descriptive analysis by means of collecting information that areimportant for universities to be considered asthe Key Success Factors (KSF of the university, and then, the design of the dashboard is made in accordance with these important factors.The result of this study is a grand design of information systems for the university performance monitoring, starting from the reception of students, faculty performance, student academic achievement, effectiveness and efficiency of services, including graduates. It is expected that by the time the system has been fully implemented, the university can take action quickly and accurately with respect to the required conditions.Keywords: Information System Dashboard; Dashboard; Academic Dashboard; University Dashboard

  16. Innovative approach for achieving of sustainable urban water supply system by using of solar photovoltaic energy

    Directory of Open Access Journals (Sweden)

    Jure Margeta

    2017-01-01

    Full Text Available Paper describes and analyses new and innovative concept for possible integration of solar photovoltaic (PV energy in urban water supply system (UWSS. Proposed system consists of PV generator and invertor, pump station and water reservoir. System is sized in such a manner that every his part is sized separately and after this integrated into a whole. This integration is desirable for several reasons, where the most important is the achievement of the objectives of sustainable living in urban areas i.e. achieving of sustainable urban water supply system. The biggest technological challenge associated with the use of solar, wind and other intermittent renewable energy sources RES is the realization of economically and environmentally friendly electric energy storage (EES. The paper elaborates the use of water reservoires in UWSS as EES. The proposed solution is still more expensive than the traditional and is economically acceptable today in the cases of isolated urban water system and special situations. Wider application will depend on the future trends of energy prices, construction costs of PV generators and needs for CO2 reduction by urban water infrastructure.

  17. Modernizing Distribution System Restoration to Achieve Grid Resiliency Against Extreme Weather Events: An Integrated Solution

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Chen; Wang, Jianhui; Ton, Dan

    2017-07-07

    Recent severe power outages caused by extreme weather hazards have highlighted the importance and urgency of improving the resilience of the electric power grid. As the distribution grids still remain vulnerable to natural disasters, the power industry has focused on methods of restoring distribution systems after disasters in an effective and quick manner. The current distribution system restoration practice for utilities is mainly based on predetermined priorities and tends to be inefficient and suboptimal, and the lack of situational awareness after the hazard significantly delays the restoration process. As a result, customers may experience an extended blackout, which causes large economic loss. On the other hand, the emerging advanced devices and technologies enabled through grid modernization efforts have the potential to improve the distribution system restoration strategy. However, utilizing these resources to aid the utilities in better distribution system restoration decision-making in response to extreme weather events is a challenging task. Therefore, this paper proposes an integrated solution: a distribution system restoration decision support tool designed by leveraging resources developed for grid modernization. We first review the current distribution restoration practice and discuss why it is inadequate in response to extreme weather events. Then we describe how the grid modernization efforts could benefit distribution system restoration, and we propose an integrated solution in the form of a decision support tool to achieve the goal. The advantages of the solution include improving situational awareness of the system damage status and facilitating survivability for customers. The paper provides a comprehensive review of how the existing methodologies in the literature could be leveraged to achieve the key advantages. The benefits of the developed system restoration decision support tool include the optimal and efficient allocation of repair crews

  18. Achievement motivation and level of aspiration: adolescent Ethiopian immigrants in the Israeli education system.

    Science.gov (United States)

    Horowitz, T R; Mosher, N

    1997-01-01

    This paper focuses on two questions: Are Ethiopian high school children who immigrated to Israel achievement motivated? To what extent does the presence or absence of certain components of the achievement construct in the indigenous value system of Ethiopian students affect progress at school? The study is based on pilot research conducted in Israel in 1987 for which the central research questions were: Are elements of motivation to be found in the indigenous value system of Ethiopian students? If so, what is their effect on progress at school? The research is based on a questionnaire administered to 88 Ethiopian students and 85 veteran Israeli students. The main findings of this research are: There are some elements in the socialization of Ethiopian students that can be looked upon as components of achievement motivation. These include a high level of aspiration, the ability to postpone gratification, and obedience. These elements help the Ethiopian children succeed at school. On the other hand, some elements in the socialization of Ethiopian children hinder their progress: conformity restraints on individual creativity and external locus of control.

  19. The Effect of Individualized Instruction System on the Academic Achievement Scores of Students

    Directory of Open Access Journals (Sweden)

    Ferhat Bahçeci

    2016-01-01

    Full Text Available A web-based learning portal offering individualized learning was developed by utilizing rule-based knowledge representation and artificial intelligence techniques of expert systems in order to reduce the uncertainties of learning to minimum and to construct an intelligent tutoring system. This portal offers individualized learning content based on the individual’s level of cognitive knowledge. In order to determine the effects of the developed system on the student achievement, the system was tested in an 8-week-long study on the students of Software Engineering Department of Technology Faculty. The pretest-posttest control group experimental design was used in the study. The experimental group received education with Individualized Instruction Portal while the control group received education in traditional learning environment. Academic achievement test was used as the data collection tool. In order to test the research hypotheses, data obtained from the data collection tools were analysed in terms of frequency, percentages, and dependent-independent t-test with statistical software program. Based on the results, no significant differences were found between the groups in terms of the pretest. On the other hand, significant differences were found between experimental and control group in terms of the posttest. It was concluded that individualized learning portal had positive effect on the students’ learning when used in combination with traditional learning environment.

  20. A Service Oriented Architecture Approach to Achieve Interoperability between Immunization Information Systems in Iran.

    Science.gov (United States)

    Hosseini, Masoud; Ahmadi, Maryam; Dixon, Brian E

    2014-01-01

    Clinical decision support (CDS) systems can support vaccine forecasting and immunization reminders; however, immunization decision-making requires data from fragmented, independent systems. Interoperability and accurate data exchange between immunization information systems (IIS) is an essential factor to utilize Immunization CDS systems. Service oriented architecture (SOA) and Health Level 7 (HL7) are dominant standards for web-based exchange of clinical information. We implemented a system based on SOA and HL7 v3 to support immunization CDS in Iran. We evaluated system performance by exchanging 1500 immunization records for roughly 400 infants between two IISs. System turnaround time is less than a minute for synchronous operation calls and the retrieved immunization history of infants were always identical in different systems. CDS generated reports were accordant to immunization guidelines and the calculations for next visit times were accurate. Interoperability is rare or nonexistent between IIS. Since inter-state data exchange is rare in United States, this approach could be a good prototype to achieve interoperability of immunization information.

  1. Improving University Ranking to Achieve University Competitiveness by Management Information System

    Science.gov (United States)

    Dachyar, M.; Dewi, F.

    2015-05-01

    One way to increase university competitiveness is through information system management. A literature review was done to find information system factors that affect university performance in Quacquarelli Symonds (QS) University Ranking: Asia evaluation. Information system factors were then eliminated using Delphi method through consensus of 7 experts. Result from Delphi method was used as measured variables in PLS-SEM. Estimation with PLS-SEM method through 72 respondents shows that the latent variable academic reputation and citation per paper have significant correlation to university competitiveness. In University of Indonesia (UI) the priority to increase university competitiveness as follow: (i) network building in international conference, (ii) availability of research data to public, (iii) international conference information, (iv) information on achievements and accreditations of each major, (v) ease of employment for alumni.

  2. How to achieve optimal organization of primary care service delivery at system level: lessons from Europe.

    Science.gov (United States)

    Pelone, Ferruccio; Kringos, Dionne S; Spreeuwenberg, Peter; De Belvis, Antonio G; Groenewegen, Peter P

    2013-09-01

    To measure the relative efficiency of primary care (PC) in turning their structures into services delivery and turning their services delivery into quality outcomes. Cross-sectional study based on the dataset of the Primary Healthcare Activity Monitor for Europe project. Two Data Envelopment models were run to compare the relative technical efficiency. A sensitivity analysis of the resulting efficiency scores was performed. PC systems in 22 European countries in 2009/2010. Model 1 included data on PC governance, workforce development and economic conditions as inputs and access, coordination, continuity and comprehensiveness of care as outputs. Model 2 included the previous process dimensions as inputs and quality indicators as outputs. There is relatively reasonable efficiency in all countries at delivering as many as possible PC processes at a given level of PC structure. It is particularly important to invest in economic conditions to achieve an efficient structure-process balance. Only five countries have fully efficient PC systems in turning their services delivery into high quality outcomes, using a similar combination of access, continuity and comprehensiveness, although they differ on the adoption of coordination of services. There is a large variation in efficiency levels obtained by countries with inefficient PC in turning their services delivery into quality outcomes. Maximizing the individual functions of PC without taking into account the coherence within the health-care system is not sufficient from a policymaker's point of view when aiming to achieve efficiency.

  3. Fuzzy pool balance: An algorithm to achieve a two dimensional balance in distribute storage systems

    International Nuclear Information System (INIS)

    Wu, Wenjing; Chen, Gang

    2014-01-01

    The limitation of scheduling modules and the gradual addition of disk pools in distributed storage systems often result in imbalances among their disk pools in terms of both disk usage and file count. This can cause various problems to the storage system such as single point of failure, low system throughput and imbalanced resource utilization and system loads. An algorithm named Fuzzy Pool Balance (FPB) is proposed here to solve this problem. The input of FPB is the current file distribution among disk pools and the output is a file migration plan indicating what files are to be migrated to which pools. FPB uses an array to classify the files by their sizes. The file classification array is dynamically calculated with a defined threshold named T max that defines the allowed pool disk usage deviations. File classification is the basis of file migration. FPB also defines the Immigration Pool (IP) and Emigration Pool (EP) according to the pool disk usage and File Quantity Ratio (FQR) that indicates the percentage of each category of files in each disk pool, so files with higher FQR in an EP will be migrated to IP(s) with a lower FQR of this file category. To verify this algorithm, we implemented FPB on an ATLAS Tier2 dCache production system. The results show that FPB can achieve a very good balance in both free space and file counts, and adjusting the threshold value T max and the correction factor to the average FQR can achieve a tradeoff between free space and file count.

  4. Relationship Between the Perception Curriculum Credit Semester System (Sks) with Academic Achievement Motivation in Students of Sman 78 Jakarta

    OpenAIRE

    Nurhidayah, Fajriati; Widodo, Prasetyo Budi; Desiningrum, Dinie Ratri

    2012-01-01

    School education has a major role in improving the quality of eduvation ,00aitems through the students academic achievement motivation. Students academic achievement motivation can be seen by the student perception of the curriculum semester credit system is applied in schools. This research was conducted to determine the relationship between perceptions of curriculum semester credit system with academic achievement motivation in students of SMAN 78 Jakarta. The population was 324 students w...

  5. Building America Residential System Research Results: Achieving 30% Whole House Energy Savings Level in Cold Climates

    Energy Technology Data Exchange (ETDEWEB)

    Building Industry Research Alliance (BIRA); Building Science Consortium (BSC); Consortium for Advanced Residential Buildings (CARB); Florida Solar Energy Center (FSEC); IBACOS; National Renewable Energy Laboratory (NREL)

    2006-08-01

    The Building America program conducts the system research required to reduce risks associated with the design and construction of homes that use an average of 30% to 90% less total energy for all residential energy uses than the Building America Research Benchmark, including research on homes that will use zero net energy on annual basis. To measure the program's progress, annual research milestones have been established for five major climate regions in the United States. The system research activities required to reach each milestone take from 3 to 5 years to complete and include research in individual test houses, studies in pre-production prototypes, and research studies with lead builders that provide early examples that the specified energy savings level can be successfully achieved on a production basis. This report summarizes research results for the 30% energy savings level and demonstrates that lead builders can successfully provide 30% homes in Cold Climates on a cost-neutral basis.

  6. Community-Based Disaster Risk Management in the Philippines: Achievements and Challenges of the Purok System

    Directory of Open Access Journals (Sweden)

    Angelina Matthies

    2017-06-01

    Full Text Available The purok system in the Philippines is promoted as a voluntary self-organization at the sub-village level which strengthens community resilience to natural hazards. In 2011, the system received the UN Sasakawa Award and gained prominence among the practitioner community. Based on a qualitative study in the municipality of San Francisco (Cebu province from December 2014 to March 2015, the article elaborates on the achievements and challenges of the purok system. Striking merits encompass efficient and effective information dissemination and evacuation measurements between all levels of political administration that stem from the system’s remarkable enforcement of human and social capital. This is underpinned by a clear determination of roles and responsibility that is subsumed under the concept of accountability. However, the purok system faces internal challenges of maintenance and implies profound conceptual ambiguities regarding the notion of voluntarism and capabilities that favor clientelism. Nevertheless, the purok system clearly distinguishes itself from conventional community-based disaster risk management practices and implies potentials that are highly beneficial for strengthening resilience in disaster prone areas.

  7. Taking advantage of ground data systems attributes to achieve quality results in testing software

    Science.gov (United States)

    Sigman, Clayton B.; Koslosky, John T.; Hageman, Barbara H.

    1994-01-01

    During the software development life cycle process, basic testing starts with the development team. At the end of the development process, an acceptance test is performed for the user to ensure that the deliverable is acceptable. Ideally, the delivery is an operational product with zero defects. However, the goal of zero defects is normally not achieved but is successful to various degrees. With the emphasis on building low cost ground support systems while maintaining a quality product, a key element in the test process is simulator capability. This paper reviews the Transportable Payload Operations Control Center (TPOCC) Advanced Spacecraft Simulator (TASS) test tool that is used in the acceptance test process for unmanned satellite operations control centers. The TASS is designed to support the development, test and operational environments of the Goddard Space Flight Center (GSFC) operations control centers. The TASS uses the same basic architecture as the operations control center. This architecture is characterized by its use of distributed processing, industry standards, commercial off-the-shelf (COTS) hardware and software components, and reusable software. The TASS uses much of the same TPOCC architecture and reusable software that the operations control center developer uses. The TASS also makes use of reusable simulator software in the mission specific versions of the TASS. Very little new software needs to be developed, mainly mission specific telemetry communication and command processing software. By taking advantage of the ground data system attributes, successful software reuse for operational systems provides the opportunity to extend the reuse concept into the test area. Consistency in test approach is a major step in achieving quality results.

  8. The approximate number system and its relation to early math achievement: evidence from the preschool years.

    Science.gov (United States)

    Bonny, Justin W; Lourenco, Stella F

    2013-03-01

    Humans rely on two main systems of quantification; one is nonsymbolic and involves approximate number representations (known as the approximate number system or ANS), and the other is symbolic and allows for exact calculations of number. Despite the pervasiveness of the ANS across development, recent studies with adolescents and school-aged children point to individual differences in the precision of these representations that, importantly, have been shown to relate to symbolic math competence even after controlling for general aspects of intelligence. Such findings suggest that the ANS, which humans share with nonhuman animals, interfaces specifically with a uniquely human system of formal mathematics. Other findings, however, point to a less straightforward picture, leaving open questions about the nature and ontogenetic origins of the relation between these two systems. Testing children across the preschool period, we found that ANS precision correlated with early math achievement but, critically, that this relation was nonlinear. More specifically, the correlation between ANS precision and math competence was stronger for children with lower math scores than for children with higher math scores. Taken together, our findings suggest that early-developing connections between the ANS and mathematics may be fundamentally discontinuous. Possible mechanisms underlying such nonlinearity are discussed. Copyright © 2012 Elsevier Inc. All rights reserved.

  9. Achievable Rates of UAV-Relayed Cooperative Cognitive Radio MIMO Systems

    KAUST Repository

    Sboui, Lokman; Ghazzai, Hakim; Rezki, Zouheir; Alouini, Mohamed-Slim

    2017-01-01

    We study the achievable rate of an uplink MIMO cognitive radio system where the primary user (PU) and the secondary user (SU) aim to communicate to the closest primary base station (BS) via a multi-access channel through the same unmanned aerial vehicle (UAV) relay. The SU message is then forwarded from the primary BS to the secondary network with a certain incentive reward as a part of the cooperation protocol between both networks. A special linear precoding scheme is proposed to enable the SU to exploit the PU free eigenmodes. We analyze two scenarios in which the UAV relay gain matrix is either fixed or optimized. We derive the optimal power allocation that maximizes the achievable rate of the SU respecting power budget, interference, and relay power constraints. Numerical results highlight the cognitive rate gain of our proposed scheme with respect to various problem parameters. We also highlight the effect of UAV altitude on the SU and PU rates. Finally, when the relay matrix is optimized, we show that the PU rate is remarkably enhanced and that the SU rate is only improved at high power regime.

  10. Probability of Loss of Crew Achievability Studies for NASA's Exploration Systems Development

    Science.gov (United States)

    Boyer, Roger L.; Bigler, Mark; Rogers, James H.

    2015-01-01

    Over the last few years, NASA has been evaluating various vehicle designs for multiple proposed design reference missions (DRM) beyond low Earth orbit in support of its Exploration Systems Development (ESD) programs. This paper addresses several of the proposed missions and the analysis techniques used to assess the key risk metric, probability of loss of crew (LOC). Probability of LOC is a metric used to assess the safety risk as well as a design requirement. These risk assessments typically cover the concept phase of a DRM, i.e. when little more than a general idea of the mission is known and are used to help establish "best estimates" for proposed program and agency level risk requirements. These assessments or studies were categorized as LOC achievability studies to help inform NASA management as to what "ball park" estimates of probability of LOC could be achieved for each DRM and were eventually used to establish the corresponding LOC requirements. Given that details of the vehicles and mission are not well known at this time, the ground rules, assumptions, and consistency across the programs become the important basis of the assessments as well as for the decision makers to understand.

  11. Achievable Rates of UAV-Relayed Cooperative Cognitive Radio MIMO Systems

    KAUST Repository

    Sboui, Lokman

    2017-04-19

    We study the achievable rate of an uplink MIMO cognitive radio system where the primary user (PU) and the secondary user (SU) aim to communicate to the closest primary base station (BS) via a multi-access channel through the same unmanned aerial vehicle (UAV) relay. The SU message is then forwarded from the primary BS to the secondary network with a certain incentive reward as a part of the cooperation protocol between both networks. A special linear precoding scheme is proposed to enable the SU to exploit the PU free eigenmodes. We analyze two scenarios in which the UAV relay gain matrix is either fixed or optimized. We derive the optimal power allocation that maximizes the achievable rate of the SU respecting power budget, interference, and relay power constraints. Numerical results highlight the cognitive rate gain of our proposed scheme with respect to various problem parameters. We also highlight the effect of UAV altitude on the SU and PU rates. Finally, when the relay matrix is optimized, we show that the PU rate is remarkably enhanced and that the SU rate is only improved at high power regime.

  12. Achieving Population-Level Change Through a System-Contextual Approach to Supporting Competent Parenting.

    Science.gov (United States)

    Sanders, Matthew R; Burke, Kylie; Prinz, Ronald J; Morawska, Alina

    2017-03-01

    The quality of parenting children receive affects a diverse range of child and youth outcomes. Addressing the quality of parenting on a broad scale is a critical part of producing a more nurturing society. To achieve a meaningful population-level reduction in the prevalence rates of child maltreatment and social and emotional problems that are directly or indirectly influenced by parenting practices requires the adoption of a broad ecological perspective in supporting families to raise children. We make the case for adopting a multilevel, whole of population approach to enhance competent parenting and describe the essential tasks that must be accomplished for the approach to be successful and its effects measurable. We describe how a theoretically integrated system of parenting support based on social learning and cognitive behavioral principles can be further strengthened when the broader community supports parental participation. Implications for policy and practice are discussed.

  13. The contribution of human resources management systems in achieving competitive advantage

    Directory of Open Access Journals (Sweden)

    Anuta Porutiu

    2010-12-01

    Full Text Available Competition has become a current and difficult problem for any organization. This raises the need for the companies to obtain competitive advantages. One way to do this is making use of appropriate information technology, which is the task of information systems for top management. Computer technology and data communication technology alter the parameters within which competition unfolds in all fields. Whereas in the past information technology was oriented to data storage, in the modern world it must provide a dynamic vision on the organization, facilitating adaptation to changes in business environment and thus ensuring competitiveness. In this way, information technology becomes a competitive weapon which is extremely effective in achieving the objectives of the organization. In addition, it is applicable in any field of activity regardless of the organization’s size.

  14. A system dynamics optimization framework to achieve population desired of average weight target

    Science.gov (United States)

    Abidin, Norhaslinda Zainal; Zulkepli, Jafri Haji; Zaibidi, Nerda Zura

    2017-11-01

    Obesity is becoming a serious problem in Malaysia as it has been rated as the highest among Asian countries. The aim of the paper is to propose a system dynamics (SD) optimization framework to achieve population desired weight target based on the changes in physical activity behavior and its association to weight and obesity. The system dynamics approach of stocks and flows diagram was used to quantitatively model the impact of both behavior on the population's weight and obesity trends. This work seems to bring this idea together and highlighting the interdependence of the various aspects of eating and physical activity behavior on the complex of human weight regulation system. The model was used as an experimentation vehicle to investigate the impacts of changes in physical activity on weight and prevalence of obesity implications. This framework paper provides evidence on the usefulness of SD optimization as a strategic decision making approach to assist in decision making related to obesity prevention. SD applied in this research is relatively new in Malaysia and has a high potential to apply to any feedback models that address the behavior cause to obesity.

  15. Safety management systems and their role in achieving high standards of operational safety

    International Nuclear Information System (INIS)

    Coulston, D.J.; Baylis, C.C.

    2000-01-01

    Achieving high standards of operational safety requires a robust management framework that is visible to all personnel with responsibility for its implementation. The structure of the management framework must ensure that all processes used to manage safety interlink in a logical and coherent manner, that is, they form a management system that leads to continuous improvement in safety performance. This Paper describes BNFL's safety management system (SMS). The SMS has management processes grouped within 5 main elements: 1. Policy, 2. Organisation, 3. Planning and Implementation, 4. Measuring and Reviewing Performance, 5. Audit. These elements reflect the overall process of setting safety objective (from Policy), measuring success and reviewing the performance. Effective implementation of the SMS requires senior managers to demonstrate leadership through their commitment and accountability. However, the SMS as a whole reflects that every employee at every level within BNFL is responsible for safety of operations under their control. The SMS therefore promotes a proactive safety culture and safe operations. The system is formally documented in the Company's Environmental, Health and Safety (EHS) Manual. Within in BNFL Group, the Company structures enables the Manual to provide overall SMS guidance and co-ordination to its range of nuclear businesses. Each business develops the SMS to be appropriate at all levels of its organisation, but ensuring that each level is consistent with the higher level. The Paper concludes with a summary of BNFL's safety performance. (author)

  16. Autonomous Information Fading and Provision to Achieve High Response Time in Distributed Information Systems

    Science.gov (United States)

    Lu, Xiaodong; Arfaoui, Helene; Mori, Kinji

    In highly dynamic electronic commerce environment, the need for adaptability and rapid response time to information service systems has become increasingly important. In order to cope with the continuously changing conditions of service provision and utilization, Faded Information Field (FIF) has been proposed. FIF is a distributed information service system architecture, sustained by push/pull mobile agents to bring high-assurance of services through a recursive demand-oriented provision of the most popular information closer to the users to make a tradeoff between the cost of information service allocation and access. In this paper, based on the analysis of the relationship that exists among the users distribution, information provision and access time, we propose the technology for FIF design to resolve the competing requirements of users and providers to improve users' access time. In addition, to achieve dynamic load balancing with changing users preference, the autonomous information reallocation technology is proposed. We proved the effectiveness of the proposed technology through the simulation and comparison with the conventional system.

  17. Relationships of cognitive and metacognitive learning strategies to mathematics achievement in four high-performing East Asian education systems.

    Science.gov (United States)

    Areepattamannil, Shaljan; Caleon, Imelda S

    2013-01-01

    The authors examined the relationships of cognitive (i.e., memorization and elaboration) and metacognitive learning strategies (i.e., control strategies) to mathematics achievement among 15-year-old students in 4 high-performing East Asian education systems: Shanghai-China, Hong Kong-China, Korea, and Singapore. In all 4 East Asian education systems, memorization strategies were negatively associated with mathematics achievement, whereas control strategies were positively associated with mathematics achievement. However, the association between elaboration strategies and mathematics achievement was a mixed bag. In Shanghai-China and Korea, elaboration strategies were not associated with mathematics achievement. In Hong Kong-China and Singapore, on the other hand, elaboration strategies were negatively associated with mathematics achievement. Implications of these findings are briefly discussed.

  18. STATE-OF-THE-ART TASKS AND ACHIEVEMENTS OF PARALINGUISTIC SPEECH ANALYSIS SYSTEMS

    Directory of Open Access Journals (Sweden)

    A. A. Karpov

    2016-07-01

    Full Text Available We present analytical survey of state-of-the-art actual tasks in the area of computational paralinguistics, as well as the recent achievements of automatic systems for paralinguistic analysis of conversational speech. Paralinguistics studies non-verbal aspects of human communication and speech such as: natural emotions, accents, psycho-physiological states, pronunciation features, speaker’s voice parameters, etc. We describe architecture of a baseline computer system for acoustical paralinguistic analysis, its main components and useful speech processing methods. We present some information on an International contest called Computational Paralinguistics Challenge (ComParE, which is held each year since 2009 in the framework of the International conference INTERSPEECH organized by the International Speech Communication Association. We present sub-challenges (tasks that were proposed at the ComParE Challenges in 2009-2016, and analyze winning computer systems for each sub-challenge and obtained results. The last completed ComParE-2015 Challenge was organized in September 2015 in Germany and proposed 3 sub-challenges: 1 Degree of Nativeness (DN sub-challenge, determination of nativeness degree of speakers based on acoustics; 2 Parkinson's Condition (PC sub-challenge, recognition of a degree of Parkinson’s condition based on speech analysis; 3 Eating Condition (EC sub-challenge, determination of the eating condition state during speaking or a dialogue, and classification of consumed food type (one of seven classes of food by the speaker. In the last sub-challenge (EC, the winner was a joint Turkish-Russian team consisting of the authors of the given paper. We have developed the most efficient computer-based system for detection and classification of the corresponding (EC acoustical paralinguistic events. The paper deals with the architecture of this system, its main modules and methods, as well as the description of used training and evaluation

  19. HOST-GUEST INTERACTION OF PESTICIDE BIFENOX WITH CYCLODEXTRIN MOLECULES. AN ELECTROCHEMICAL STUDY

    Czech Academy of Sciences Publication Activity Database

    Hromadová, Magdaléna; Sokolová, Romana; Pospíšil, Lubomír; Lachmanová, Štěpánka; Fanelli, N.; Giannarelli, S.

    2009-01-01

    Roč. 74, 11-12 (2009), s. 1647-1664 ISSN 0010-0765 R&D Projects: GA AV ČR IAA400400802; GA ČR GA203/08/1157; GA ČR GA203/09/0705; GA ČR GA203/09/1607; GA MŠk LC510; GA MŠk OC 140 Institutional research plan: CEZ:AV0Z40400503 Keywords : reductions * electroreduction * nitro anion radical * electrochemistry Subject RIV: CG - Electrochemistry Impact factor: 0.856, year: 2009

  20. Host-Guest Interaction between Herbicide Oxadiargyl and Hydroxypropyl- β -Cyclodextrin

    Directory of Open Access Journals (Sweden)

    Sofia Benfeito

    2013-01-01

    Full Text Available In the face of a growing human population and increased urbanization, the demand for pesticides will simply rise. Farmers must escalate yields on increasingly fewer farm acres. However, the risks of pesticides, whether real or perceived, may force changes in the way these chemicals are used. Scientists are working toward pest control plans that are environmentally sound, effective, and profitable. In this context the development of new pesticide formulations which may improve application effectiveness, safety, handling, and storage can be pointed out as a solution. As a contribution to the area, the microencapsulation of the herbicide oxadiargyl (OXA in (2-hydroxypropyl-β-cyclodextrin (HP-β-CD was performed. The study was conducted in different aqueous media (ultrapure water and in different pH buffer solutions. In all cases an increment of the oxadiargyl solubility as a function of the HP-β-CD concentration that has been related to the formation of an inclusion complex was verified. UV-Vis and NMR experiments allowed concluding that the stoichiometry of the OXA/HP-β-CD complex formed is 1 : 1. The gathered results can be regarded as an important step for its removal from industrial effluents and/or to increase the stabilizing action, encapsulation, and adsorption in water treatment plants.

  1. Uniaxial negative thermal expansion facilitated by weak host-guest interactions.

    Science.gov (United States)

    Engel, Emile R; Smith, Vincent J; Bezuidenhout, Charl X; Barbour, Leonard J

    2014-04-25

    A nitromethane solvate of 18-crown-6 was investigated by means of variable-temperature single-crystal X-ray diffraction in response to a report of abnormal unit cell contraction. Exceptionally large positive thermal expansion in two axial directions and negative thermal expansion along the third was confirmed. The underlying mechanism relies exclusively on weak electrostatic interactions to yield a linear thermal expansion coefficient of -129 × 10(-6) K(-1), the largest negative value yet observed for an organic inclusion compound.

  2. Molecular Recognition of Vesicles : Host-Guest Interactions Combined with Specific Dimerization of Zwitterions

    NARCIS (Netherlands)

    Voskuhl, Jens; Fenske, Tassilo; Stuart, Marc C. A.; Wibbeling, Birgit; Schmuck, Carsten; Ravoo, Bart Jan

    2010-01-01

    The aggregation of beta-cyclodextrin vesicles can be induced by an adamantyl-substituted zwitterionic guanidiniocarbonylpyrrole carboxylate guest molecule (1). Upon addition of 1 to the cyclodextrin vesicles at neutral pH, the vesicles aggregate (but do not fuse), as shown by using UV/Vis and

  3. New dendrimer - Peptide host - Guest complexes: Towards dendrimers as peptide carriers

    DEFF Research Database (Denmark)

    Boas, Ulrik; Sontjens, S.H.M.; Jensen, Knud Jørgen

    2002-01-01

    Adamantyl urea and adamantyl thiourea modified poly(propylene imine) dendrimers act as hosts for N-terminal tert-butoxycarbonyl (Boc)-protected peptides and form chloroform-soluble complexes. investigations with NMR spectroscopy show that the peptide is bound to the dendrimer by ionic interactions...... between the dendrimer outer shell tertiary amines and the C-terminal carboxylic acid of the peptide, and also through host-urea to peptide-amide hydrogen bonding. The hydrogen-bonding nature of the peptide dendrimer interactions was further confirmed by using Fourier transform IR spectroscopy, for which...... the NH- and CO-stretch signals of the peptide amide moieties shift towards lower wave-numbers upon complexation with the dendrimer. Spatial analysis of the complexes with NOESY spectroscopy generally shows close proximity of the N-terminal Boc group of the peptide to the peripheral adamantyl groups...

  4. New dendrimer - peptide host - guest complexes : towards dendrimers as peptide carriers

    NARCIS (Netherlands)

    Boas, U.; Sontjens, S.H.M.; Jensen, K.J.; Christensen, J.B.; Meijer, E.W.

    2002-01-01

    Adamantyl urea and adamantyl thiourea modified poly(propylene imine) dendrimers act as hosts for N-terminal tert-butoxycarbonyl (Boc)-protected peptides and form chloroform-soluble complexes. investigations with NMR spectroscopy show that the peptide is bound to the dendrimer by ionic interactions

  5. Clinical decision support systems for improving diagnostic accuracy and achieving precision medicine.

    Science.gov (United States)

    Castaneda, Christian; Nalley, Kip; Mannion, Ciaran; Bhattacharyya, Pritish; Blake, Patrick; Pecora, Andrew; Goy, Andre; Suh, K Stephen

    2015-01-01

    As research laboratories and clinics collaborate to achieve precision medicine, both communities are required to understand mandated electronic health/medical record (EHR/EMR) initiatives that will be fully implemented in all clinics in the United States by 2015. Stakeholders will need to evaluate current record keeping practices and optimize and standardize methodologies to capture nearly all information in digital format. Collaborative efforts from academic and industry sectors are crucial to achieving higher efficacy in patient care while minimizing costs. Currently existing digitized data and information are present in multiple formats and are largely unstructured. In the absence of a universally accepted management system, departments and institutions continue to generate silos of information. As a result, invaluable and newly discovered knowledge is difficult to access. To accelerate biomedical research and reduce healthcare costs, clinical and bioinformatics systems must employ common data elements to create structured annotation forms enabling laboratories and clinics to capture sharable data in real time. Conversion of these datasets to knowable information should be a routine institutionalized process. New scientific knowledge and clinical discoveries can be shared via integrated knowledge environments defined by flexible data models and extensive use of standards, ontologies, vocabularies, and thesauri. In the clinical setting, aggregated knowledge must be displayed in user-friendly formats so that physicians, non-technical laboratory personnel, nurses, data/research coordinators, and end-users can enter data, access information, and understand the output. The effort to connect astronomical numbers of data points, including '-omics'-based molecular data, individual genome sequences, experimental data, patient clinical phenotypes, and follow-up data is a monumental task. Roadblocks to this vision of integration and interoperability include ethical, legal

  6. Achievable rate of spectrum sharing cognitive radio systems over fading channels at low-power regime

    KAUST Repository

    Sboui, Lokman; Rezki, Zouheir; Alouini, Mohamed-Slim

    2014-01-01

    the previously achieved rate at the low-power regime. Interestingly, we show that the low-power regime analysis provides a specific insight into the maximum achievable rate behavior of CR that has not been reported by previous studies.

  7. Financing of health systems to achieve the health Millennium Development Goals in low-income countries.

    Science.gov (United States)

    Fryatt, Robert; Mills, Anne; Nordstrom, Anders

    2010-01-30

    Concern that underfunded and weak health systems are impeding the achievement of the health Millennium Development Goals in low-income countries led to the creation of a High Level Taskforce on Innovative International Financing for Health Systems in September, 2008. This report summarises the key challenges faced by the Taskforce and its Working Groups. Working Group 1 examined the constraints to scaling up and costs. Challenges included: difficulty in generalisation because of scarce and context-specific health-systems knowledge; no consensus for optimum service-delivery approaches, leading to wide cost differences; no consensus for health benefits; difficulty in quantification of likely efficiency gains; and challenges in quantification of the financing gap owing to uncertainties about financial commitments for health. Working Group 2 reviewed the different innovative mechanisms for raising and channelling funds. Challenges included: variable definitions of innovative finance; small evidence base for many innovative finance mechanisms; insufficient experience in harmonisation of global health initiatives; and inadequate experience in use of international investments to improve maternal, newborn, and child health. The various mechanisms reviewed and finally recommended all had different characteristics, some focusing on specific problems and some on raising resources generally. Contentious issues included the potential role of the private sector, the rights-based approach to health, and the move to results-based aid. The challenges and disagreements that arose during the work of the Taskforce draw attention to the many issues facing decision makers in low-income countries. International donors and recipient governments should work together to improve the evidence base for strengthening health systems, increase long-term commitments, and improve accountability through transparent and inclusive national approaches. Copyright 2010 Elsevier Ltd. All rights reserved.

  8. The realistic performance achievable with mycobacterial automated culture systems in high and low prevalence settings

    Directory of Open Access Journals (Sweden)

    Klatser Paul R

    2010-04-01

    Full Text Available Abstract Background Diagnostic tests are generally used in situations with similar pre-test probability of disease to where they were developed. When these tests are applied in situations with very different pre-test probabilities of disease, it is informative to model the likely implications of known characteristics of test performance in the new situation. This is the case for automated Mycobacterium tuberculosis (MTB liquid culture systems for tuberculosis case detection which were developed and are widely used in low burden settings but are only beginning to be applied on a large scale in high burden settings. Methods Here we model the performance of MTB liquid culture systems in high and low tuberculosis (TB prevalence settings using detailed published data concentrating on the likely frequency of cross-contamination events. Results Our model predicts that as the TB prevalence in the suspect population increases there is an exponential increase in the risk of MTB cross-contamination events expected in otherwise negative samples, even with equivalent technical performance of the laboratories. Quality control and strict cross-contamination measures become increasingly critical as the burden of MTB infection among TB suspects increases. Even under optimal conditions the realistically achievable specificity of these systems in high burden settings will likely be significantly below that obtained in low TB burden laboratories. Conclusions Liquid culture systems can play a valuable role in TB case detection in laboratories in high burden settings, but laboratory workers, policy makers and clinicians should be aware of the increased risks, independent of laboratory proficiency, of cross-contamination events in high burden settings.

  9. Mining Web-based Educational Systems to Predict Student Learning Achievements

    Directory of Open Access Journals (Sweden)

    José del Campo-Ávila

    2015-03-01

    Full Text Available Educational Data Mining (EDM is getting great importance as a new interdisciplinary research field related to some other areas. It is directly connected with Web-based Educational Systems (WBES and Data Mining (DM, a fundamental part of Knowledge Discovery in Databases. The former defines the context: WBES store and manage huge amounts of data. Such data are increasingly growing and they contain hidden knowledge that could be very useful to the users (both teachers and students. It is desirable to identify such knowledge in the form of models, patterns or any other representation schema that allows a better exploitation of the system. The latter reveals itself as the tool to achieve such discovering. Data mining must afford very complex and different situations to reach quality solutions. Therefore, data mining is a research field where many advances are being done to accommodate and solve emerging problems. For this purpose, many techniques are usually considered. In this paper we study how data mining can be used to induce student models from the data acquired by a specific Web-based tool for adaptive testing, called SIETTE. Concretely we have used top down induction decision trees algorithms to extract the patterns because these models, decision trees, are easily understandable. In addition, the conducted validation processes have assured high quality models.

  10. Achieved capability of the superconducting magnet system for the large helical device

    International Nuclear Information System (INIS)

    Satow, T.; Imagawa, S.; Yanagi, N.

    2001-01-01

    The Large Helical Device (LHD) is a plasma physics experimental device with a magnetic stored energy of 960 MJ, consisting of two sc (superconducting) helical coils and six sc poloidal coils. The trial operation and the first plasma discharge of the eight-year Phase I project for LHD were finished on 31 March 1998 as initially planned. The second experimental campaign was conducted by additional heating using two NBI devices. The third campaign started in June 1999 and was finished in January 2000. Many plasma heating tests up to a plasma field of 2.90 T were carried out. Major test results on the sc magnet system for LHD are as follows: (1) The LHD cryogenic system succeeded in 13,400-hour operation and proved its high reliability. (2) A central field of 2.91 T at a radius of 3.60 m was achieved at an H-I current of 11.08 kA, H-M current of 11.83 kA and an H-O current of 12.02 kA. (3) All six poloidal coils were excited stably. (4) Nine flexible sc bus-lines with a total length of 497 m were operated stably and safe. (author)

  11. Optimized distributed systems achieve significant performance improvement on sorted merging of massive VCF files.

    Science.gov (United States)

    Sun, Xiaobo; Gao, Jingjing; Jin, Peng; Eng, Celeste; Burchard, Esteban G; Beaty, Terri H; Ruczinski, Ingo; Mathias, Rasika A; Barnes, Kathleen; Wang, Fusheng; Qin, Zhaohui S

    2018-06-01

    Sorted merging of genomic data is a common data operation necessary in many sequencing-based studies. It involves sorting and merging genomic data from different subjects by their genomic locations. In particular, merging a large number of variant call format (VCF) files is frequently required in large-scale whole-genome sequencing or whole-exome sequencing projects. Traditional single-machine based methods become increasingly inefficient when processing large numbers of files due to the excessive computation time and Input/Output bottleneck. Distributed systems and more recent cloud-based systems offer an attractive solution. However, carefully designed and optimized workflow patterns and execution plans (schemas) are required to take full advantage of the increased computing power while overcoming bottlenecks to achieve high performance. In this study, we custom-design optimized schemas for three Apache big data platforms, Hadoop (MapReduce), HBase, and Spark, to perform sorted merging of a large number of VCF files. These schemas all adopt the divide-and-conquer strategy to split the merging job into sequential phases/stages consisting of subtasks that are conquered in an ordered, parallel, and bottleneck-free way. In two illustrating examples, we test the performance of our schemas on merging multiple VCF files into either a single TPED or a single VCF file, which are benchmarked with the traditional single/parallel multiway-merge methods, message passing interface (MPI)-based high-performance computing (HPC) implementation, and the popular VCFTools. Our experiments suggest all three schemas either deliver a significant improvement in efficiency or render much better strong and weak scalabilities over traditional methods. Our findings provide generalized scalable schemas for performing sorted merging on genetics and genomics data using these Apache distributed systems.

  12. Achieving and sustaining automated health data linkages for learning systems: barriers and solutions.

    Science.gov (United States)

    Van Eaton, Erik G; Devlin, Allison B; Devine, Emily Beth; Flum, David R; Tarczy-Hornoch, Peter

    2014-01-01

    Delivering more appropriate, safer, and highly effective health care is the goal of a learning health care system. The Agency for Healthcare Research and Quality (AHRQ) funded enhanced registry projects: (1) to create and analyze valid data for comparative effectiveness research (CER); and (2) to enhance the ability to monitor and advance clinical quality improvement (QI). This case report describes barriers and solutions from one state-wide enhanced registry project. The Comparative Effectiveness Research and Translation Network (CERTAIN) deployed the commercially available Amalga Unified Intelligence System™ (Amalga) as a central data repository to enhance an existing QI registry (the Automation Project). An eight-step implementation process included hospital recruitment, technical electronic health record (EHR) review, hospital-specific interface planning, data ingestion, and validation. Data ownership and security protocols were established, along with formal methods to separate data management for QI purposes and research purposes. Sustainability would come from lowered chart review costs and the hospital's desire to invest in the infrastructure after trying it. CERTAIN approached 19 hospitals in Washington State operating within 12 unaffiliated health care systems for the Automation Project. Five of the 19 completed all implementation steps. Four hospitals did not participate due to lack of perceived institutional value. Ten hospitals did not participate because their information technology (IT) departments were oversubscribed (e.g., too busy with Meaningful Use upgrades). One organization representing 22 additional hospitals expressed interest, but was unable to overcome data governance barriers in time. Questions about data use for QI versus research were resolved in a widely adopted project framework. Hospitals restricted data delivery to a subset of patients, introducing substantial technical challenges. Overcoming challenges of idiosyncratic EHR

  13. The Use of a Mobile Learning Management System at an Online University and Its Effect on Learning Satisfaction and Achievement

    OpenAIRE

    Won Sug Shin; Minseok Kang

    2015-01-01

    This study investigates online students’ acceptance of mobile learning and its influence on learning achievement using an information system success and extended technology acceptance model (TAM). Structural equation modeling was used to test the structure of individual, social, and systemic factors influencing mobile learning’s acceptance, and how said acceptance influences learning satisfaction and achievement. Unlike earlier TAM-related research that did not provide a broad view of technol...

  14. Intercropped silviculture systems, a key to achieving soil fungal community management in eucalyptus plantations.

    Directory of Open Access Journals (Sweden)

    Caio T C C Rachid

    Full Text Available Fungi are ubiquitous and important contributors to soil nutrient cycling, playing a vital role in C, N and P turnover, with many fungi having direct beneficial relationships with plants. However, the factors that modulate the soil fungal community are poorly understood. We studied the degree to which the composition of tree species affected the soil fungal community structure and diversity by pyrosequencing the 28S rRNA gene in soil DNA. We were also interested in whether intercropping (mixed plantation of two plant species could be used to select fungal species. More than 50,000 high quality sequences were analyzed from three treatments: monoculture of Eucalyptus; monoculture of Acacia mangium; and a mixed plantation with both species sampled 2 and 3 years after planting. We found that the plant type had a major effect on the soil fungal community structure, with 75% of the sequences from the Eucalyptus soil belonging to Basidiomycota and 19% to Ascomycota, and the Acacia soil having a sequence distribution of 28% and 62%, respectively. The intercropping of Acacia mangium in a Eucalyptus plantation significantly increased the number of fungal genera and the diversity indices and introduced or increased the frequency of several genera that were not found in the monoculture cultivation samples. Our results suggest that management of soil fungi is possible by manipulating the composition of the plant community, and intercropped systems can be a means to achieve that.

  15. Examples of design and achievement of vision systems for mobile robotics applications

    Science.gov (United States)

    Bonnin, Patrick J.; Cabaret, Laurent; Raulet, Ludovic; Hugel, Vincent; Blazevic, Pierre; M'Sirdi, Nacer K.; Coiffet, Philippe

    2000-10-01

    Our goal is to design and to achieve a multiple purpose vision system for various robotics applications : wheeled robots (like cars for autonomous driving), legged robots (six, four (SONY's AIBO) legged robots, and humanoid), flying robots (to inspect bridges for example) in various conditions : indoor or outdoor. Considering that the constraints depend on the application, we propose an edge segmentation implemented either in software, or in hardware using CPLDs (ASICs or FPGAs could be used too). After discussing the criteria of our choice, we propose a chain of image processing operators constituting an edge segmentation. Although this chain is quite simple and very fast to perform, results appear satisfactory. We proposed a software implementation of it. Its temporal optimization is based on : its implementation under the pixel data flow programming model, the gathering of local processing when it is possible, the simplification of computations, and the use of fast access data structures. Then, we describe a first dedicated hardware implementation of the first part, which requires 9CPLS in this low cost version. It is technically possible, but more expensive, to implement these algorithms using only a signle FPGA.

  16. Intercropped Silviculture Systems, a Key to Achieving Soil Fungal Community Management in Eucalyptus Plantations

    Science.gov (United States)

    Rachid, Caio T. C. C.; Balieiro, Fabiano C.; Fonseca, Eduardo S.; Peixoto, Raquel Silva; Chaer, Guilherme M.; Tiedje, James M.; Rosado, Alexandre S.

    2015-01-01

    Fungi are ubiquitous and important contributors to soil nutrient cycling, playing a vital role in C, N and P turnover, with many fungi having direct beneficial relationships with plants. However, the factors that modulate the soil fungal community are poorly understood. We studied the degree to which the composition of tree species affected the soil fungal community structure and diversity by pyrosequencing the 28S rRNA gene in soil DNA. We were also interested in whether intercropping (mixed plantation of two plant species) could be used to select fungal species. More than 50,000 high quality sequences were analyzed from three treatments: monoculture of Eucalyptus; monoculture of Acacia mangium; and a mixed plantation with both species sampled 2 and 3 years after planting. We found that the plant type had a major effect on the soil fungal community structure, with 75% of the sequences from the Eucalyptus soil belonging to Basidiomycota and 19% to Ascomycota, and the Acacia soil having a sequence distribution of 28% and 62%, respectively. The intercropping of Acacia mangium in a Eucalyptus plantation significantly increased the number of fungal genera and the diversity indices and introduced or increased the frequency of several genera that were not found in the monoculture cultivation samples. Our results suggest that management of soil fungi is possible by manipulating the composition of the plant community, and intercropped systems can be a means to achieve that. PMID:25706388

  17. Intercropped silviculture systems, a key to achieving soil fungal community management in eucalyptus plantations.

    Science.gov (United States)

    Rachid, Caio T C C; Balieiro, Fabiano C; Fonseca, Eduardo S; Peixoto, Raquel Silva; Chaer, Guilherme M; Tiedje, James M; Rosado, Alexandre S

    2015-01-01

    Fungi are ubiquitous and important contributors to soil nutrient cycling, playing a vital role in C, N and P turnover, with many fungi having direct beneficial relationships with plants. However, the factors that modulate the soil fungal community are poorly understood. We studied the degree to which the composition of tree species affected the soil fungal community structure and diversity by pyrosequencing the 28S rRNA gene in soil DNA. We were also interested in whether intercropping (mixed plantation of two plant species) could be used to select fungal species. More than 50,000 high quality sequences were analyzed from three treatments: monoculture of Eucalyptus; monoculture of Acacia mangium; and a mixed plantation with both species sampled 2 and 3 years after planting. We found that the plant type had a major effect on the soil fungal community structure, with 75% of the sequences from the Eucalyptus soil belonging to Basidiomycota and 19% to Ascomycota, and the Acacia soil having a sequence distribution of 28% and 62%, respectively. The intercropping of Acacia mangium in a Eucalyptus plantation significantly increased the number of fungal genera and the diversity indices and introduced or increased the frequency of several genera that were not found in the monoculture cultivation samples. Our results suggest that management of soil fungi is possible by manipulating the composition of the plant community, and intercropped systems can be a means to achieve that.

  18. Quota election system as a way of achieving descriptive and substantive representation of women in parliaments

    Directory of Open Access Journals (Sweden)

    Mršević Zorica

    2007-01-01

    Full Text Available In ten chapters of the text are analyzed issues of under representation of women in legislative bodies (descriptive representation matched with possibilities of their substantive representation. The substantive representation means contribution of women MPs in development and promotion of "women's politics" and politics of representing specific interest of women's part of population. In chapters under the titles, Underrepresented sex, Quota term, and Myths on quotas, are presented the main characteristics of the issues of women's under representation from political mainstream and decision-making bodies. There is also analyzed quota preferential electoral system as a solution. The gist of the text is comprised in the chapter Why Quotas where are presented the classical arguments for quotas as a specific measure of affirmative action. The way from increasing quantitative presence of women in legislative bodies to increasing the qualitative level of their activities in there is elaborated in the chapters Increasing numbers and achieving quality, Issues of women's political efficiency, Criteria of changes, and Inter parliamentarian activities of women. In the chapter Women's issues and women's perspectives is defined difference between these two aspects of women's MPs activities. Women's issues are those issues influencing directly women on physical or social way (e.g. breast cancer, reproductive rights, gender based discrimination, politics of child's care. The women's perspectives are specific women's interest and views of all other political issues.

  19. A National Early Intervention System as a Strategy to Promote Inclusion and Academic Achievement in Portugal

    Directory of Open Access Journals (Sweden)

    Vitor Franco

    2017-07-01

    Full Text Available Early intervention with children at risk or facing developmental problems is a practice defined by three fundamental characteristics: being family-centered, being based on the community and on the child’s life context, and being conducted by a team with transdisciplinary practice. In this paper we wish to present how the SNIPI-National System of Early Intervention, implemented in Portugal over the past 15 years, contributes to promote maximum development and the full inclusion of children up to 6 years of age and works to prevent school failure. The SNIPI covers the entire territory and intends to respond to the needs of children with developmental disorders or those in at risk situations. This community-based early intervention model is linked to the health, education and social care systems, involving the three responsible Ministries. In the present community case study, we present the implementation of this program in the Alentejo region, involving 31 local teams and almost 2500 children. Through the regional structure’s reports and the responses of parents and professionals in impact studies, we demonstrate how the system is established and how it tackles school failure and improves the educational inclusion of these children. The impact of this Early Intervention model has been significant not only on children’s developmental outcomes, but also for the health, education and social care professionals who work in a transdisciplinary perspective, as well as for the families who became more skilled at evaluating the children’s needs and the support provided. This approach to implementing a family-centered Early Intervention program can contribute to full inclusion. It facilitates the transition to schooling based on a non-discriminatory approach and educational achievement by aiding development and an adapted contextualization in pre-school education. This program system introduces significant innovation within the framework of existing

  20. A National Early Intervention System as a Strategy to Promote Inclusion and Academic Achievement in Portugal.

    Science.gov (United States)

    Franco, Vitor; Melo, Madalena; Santos, Graça; Apolónio, Ana; Amaral, Leonor

    2017-01-01

    Early intervention with children at risk or facing developmental problems is a practice defined by three fundamental characteristics: being family-centered, being based on the community and on the child's life context, and being conducted by a team with transdisciplinary practice. In this paper we wish to present how the SNIPI-National System of Early Intervention, implemented in Portugal over the past 15 years, contributes to promote maximum development and the full inclusion of children up to 6 years of age and works to prevent school failure. The SNIPI covers the entire territory and intends to respond to the needs of children with developmental disorders or those in at risk situations. This community-based early intervention model is linked to the health, education and social care systems, involving the three responsible Ministries. In the present community case study, we present the implementation of this program in the Alentejo region, involving 31 local teams and almost 2500 children. Through the regional structure's reports and the responses of parents and professionals in impact studies, we demonstrate how the system is established and how it tackles school failure and improves the educational inclusion of these children. The impact of this Early Intervention model has been significant not only on children's developmental outcomes, but also for the health, education and social care professionals who work in a transdisciplinary perspective, as well as for the families who became more skilled at evaluating the children's needs and the support provided. This approach to implementing a family-centered Early Intervention program can contribute to full inclusion. It facilitates the transition to schooling based on a non-discriminatory approach and educational achievement by aiding development and an adapted contextualization in pre-school education. This program system introduces significant innovation within the framework of existing educational policies that

  1. Achievable Information Rates for Coded Modulation With Hard Decision Decoding for Coherent Fiber-Optic Systems

    Science.gov (United States)

    Sheikh, Alireza; Amat, Alexandre Graell i.; Liva, Gianluigi

    2017-12-01

    We analyze the achievable information rates (AIRs) for coded modulation schemes with QAM constellations with both bit-wise and symbol-wise decoders, corresponding to the case where a binary code is used in combination with a higher-order modulation using the bit-interleaved coded modulation (BICM) paradigm and to the case where a nonbinary code over a field matched to the constellation size is used, respectively. In particular, we consider hard decision decoding, which is the preferable option for fiber-optic communication systems where decoding complexity is a concern. Recently, Liga \\emph{et al.} analyzed the AIRs for bit-wise and symbol-wise decoders considering what the authors called \\emph{hard decision decoder} which, however, exploits \\emph{soft information} of the transition probabilities of discrete-input discrete-output channel resulting from the hard detection. As such, the complexity of the decoder is essentially the same as the complexity of a soft decision decoder. In this paper, we analyze instead the AIRs for the standard hard decision decoder, commonly used in practice, where the decoding is based on the Hamming distance metric. We show that if standard hard decision decoding is used, bit-wise decoders yield significantly higher AIRs than symbol-wise decoders. As a result, contrary to the conclusion by Liga \\emph{et al.}, binary decoders together with the BICM paradigm are preferable for spectrally-efficient fiber-optic systems. We also design binary and nonbinary staircase codes and show that, in agreement with the AIRs, binary codes yield better performance.

  2. FIASCO II failure to achieve a satisfactory cardiac outcome study: the elimination of system errors.

    Science.gov (United States)

    Farid, Shakil; Page, Aravinda; Jenkins, David; Jones, Mark T; Freed, Darren; Nashef, Samer A M

    2013-07-01

    Death in low-risk cardiac surgical patients provides a simple and accessible method by which modifiable causes of death can be identified. In the first FIASCO study published in 2009, local potentially modifiable causes of preventable death in low-risk patients with a logistic EuroSCORE of 0-2 undergoing cardiac surgery were inadequate myocardial protection and lack of clarity in the chain of responsibility. As a result, myocardial protection was improved, and a formalized system introduced to ensure clarity of the chain of responsibility in the care of all cardiac surgical patients. The purpose of the current study was to re-audit outcomes in low-risk patients to see if improvements have been achieved. Patients with a logistic EuroSCORE of 0-2 who had cardiac surgery from January 2006 to August 2012 were included. Data were prospectively collected and retrospectively analysed. The case notes of patients who died in hospital were subject to internal and external review and classified according to preventability. Two thousand five hundred and forty-nine patients with a logistic EuroSCORE of 0-2 underwent cardiac surgery during the study period. Seven deaths occurred in truly low-risk patients, giving a mortality of 0.27%. Of the seven, three were considered preventable and four non-preventable. Mortality was marginally lower than in our previous study (0.37%), and no death occurred as a result of inadequate myocardial protection or communication failures. We postulate that the regular study of such events in all institutions may unmask systemic errors that can be remedied to prevent or reduce future occurrences. We encourage all units to use this methodology to detect any similarly modifiable factors in their practice.

  3. The State Education Is In: Recognising the Challenge of Achieving a Fair Educational System in Post-Brexit, Austerity England

    Science.gov (United States)

    Reay, Diane

    2017-01-01

    This article examines the problem of the wider economic and political context for any project aimed at achieving a fairer educational system. The consequences of the current status quo can be seen in diminishing funding and rising inequalities. The author argues that the answer lies not in tinkering with an unjust education system but rather in…

  4. The Use of a Mobile Learning Management System at an Online University and Its Effect on Learning Satisfaction and Achievement

    Science.gov (United States)

    Shin, Won Sug; Kang, Minseok

    2015-01-01

    This study investigates online students' acceptance of mobile learning and its influence on learning achievement using an information system success and extended technology acceptance model (TAM). Structural equation modeling was used to test the structure of individual, social, and systemic factors influencing mobile learning's acceptance, and…

  5. Impact of the Systemic Approach on Literacy Achievement of Jordanian 1st Graders at Mu'tah University Model School

    Science.gov (United States)

    Al-Hajaya, Nail

    2012-01-01

    This study investigates the effect of the systemic approach in literacy achievement of the first grade students at Mu'tah University's Model School. The sample (N = 45) consisted of all first grade students, who were assigned into two groups; a control group taught traditionally while the other group was exposed to the system approach during the…

  6. Double level selection in a constitutional dynamic library of coordination driven supramolecular polygons.

    Science.gov (United States)

    Rancan, Marzio; Tessarolo, Jacopo; Casarin, Maurizio; Zanonato, Pier Luigi; Quici, Silvio; Armelao, Lidia

    2014-07-21

    A constitutional dynamic library (CDL) of Cu(II) metallo-supramolecular polygons has been studied as a bench test to examine an interesting selection case based on molecular recognition. Sorting of the CDL polygons is achieved through a proper guest that is hosted into the triangular metallo-macrocycle constituent. Two selection mechanisms are observed, a guest induced path and a guest templated self-assembly (virtual library approach). Remarkably, the triangular host can accommodate several guests with a degree of selectivity ranging from ∼1 to ∼10(4) for all possible guest pairs. A double level selection operates: guests drive the CDL toward the triangular polygon, and, at the same time, this is able to pick a specific guest from a set of competitive molecules, according to a selectivity-affinity correlation. Association constants of the host-guest systems have been determined. Guest competition and exchange studies have been analyzed through variable temperature UV-Vis absorption spectroscopy and single crystal X-ray diffraction studies. Molecular structures and electronic properties of the triangular polygon and of the host-guest systems also have been studied by means of all electrons density functional theory (DFT) and time-dependent density functional theory (TDDFT) calculations including dispersive contributions. DFT outcomes ultimately indicate the dispersive nature of the host-guest interactions, while TDDFT results allow a thorough assignment of the host and host-guests spectral features.

  7. DYNAMIC SYSTEM APPROACH IN PSYCHOLOGY: PROPOSITION AND APPLICATION IN THE STUDY OF EMOTION, APPRAISAL AND COGNITIVE ACHIEVEMENT

    Directory of Open Access Journals (Sweden)

    Cristiano M. A. Gomes

    2013-07-01

    Full Text Available Psychological processes are difficult to be studied due to their complexity. The dynamic system approach shows itself as a good tool for psychology to deal with this complexity issue. We propose two fundamental contributions of the dynamic system approach to psychology and apply it in the study of achievement emotions, appraisal and cognitive achievement. Two hypotheses were investigated: 1 More than one correlation pattern between test achievement, appraisal and emotion will be found; 2 Test achievement, appraisal and emotion form a dynamic system which will be explained by a latent variable that is dependent on the previous state of the system. A sample of thirteen students from seventh to ninth grades performed an inductive reasoning test, appraised their achievement, and declared their emotional valences (from extreme positive to extreme negative. Each variable was measured in 20 different occasions. One correlation matrix of each individual was generated and seven qualitative profiles were identified. Then four different states of relations between the variables were identified through a hidden Markov model. The two hypotheses were not refuted. It’s concluded that the dynamic system approach brings new possibilities to the study of psychological processes.

  8. State School Finance System Variance Impacts on Student Achievement: Inadequacies in School Funding

    Science.gov (United States)

    Hoffman, Michael J.; Wiggall, Richard L.; Dereshiwsky, Mary I.; Emanuel, Gary L.

    2013-01-01

    Adequate funding for the nation's schools to meet the call for higher student achievement has been a litigious issue. Spending on schools is a political choice. The choices made by state legislatures, in some cases, have failed to fund schools adequately and have incited school finance lawsuits in almost all states. These proceedings are generally…

  9. On the achievable performance using variable geometry active secondary suspension systems in commercial vehicles

    NARCIS (Netherlands)

    Evers, W.J.; Besselink, I.G.M.; Teerhuis, A.P.; Nijmeijer, H.

    2011-01-01

    There is a need to further improve driver comfort in commercial vehicles. The variable geometry active suspension offers an interesting option to achieve this in an energy efficient way. However, the optimal control strategy and the overal performance potential remains unclear. The aim of this paper

  10. Aberrant Learning Achievement Detection Based on Person-Fit Statistics in Personalized e-Learning Systems

    Science.gov (United States)

    Liu, Ming-Tsung; Yu, Pao-Ta

    2011-01-01

    A personalized e-learning service provides learning content to fit learners' individual differences. Learning achievements are influenced by cognitive as well as non-cognitive factors such as mood, motivation, interest, and personal styles. This paper proposes the Learning Caution Indexes (LCI) to detect aberrant learning patterns. The philosophy…

  11. Towards Achieving a Critical Thinking Society in Malaysia: A Challenge to School Libraries and Educational Systems.

    Science.gov (United States)

    Yaacob, Raja Abdullah; Seman, Norma Abur

    One of the challenges facing Malaysia amidst its economic development is the achievement of a critical thinking society. This would enhance and guarantee the success of research and development programs in addition to having other socioeconomic effects. This paper covers the following topics: Vision 2020, Malaysia's goal to reach developed nation…

  12. Achieving a 100% Renewable Grid: Operating Electric Power Systems with Extremely High Levels of Variable Renewable Energy

    Energy Technology Data Exchange (ETDEWEB)

    Kroposki, Benjamin; Johnson, Brian; Zhang, Yingchen; Gevorgian, Vahan; Denholm, Paul; Hodge, Bri-Mathias; Hannegan, Bryan

    2017-03-01

    What does it mean to achieve a 100% renewable grid? Several countries already meet or come close to achieving this goal. Iceland, for example, supplies 100% of its electricity needs with either geothermal or hydropower. Other countries that have electric grids with high fractions of renewables based on hydropower include Norway (97%), Costa Rica (93%), Brazil (76%), and Canada (62%). Hydropower plants have been used for decades to create a relatively inexpensive, renewable form of energy, but these systems are limited by natural rainfall and geographic topology. Around the world, most good sites for large hydropower resources have already been developed. So how do other areas achieve 100% renewable grids? Variable renewable energy (VRE), such as wind and solar photovoltaic (PV) systems, will be a major contributor, and with the reduction in costs for these technologies during the last five years, large-scale deployments are happening around the world.

  13. An Augmented Reality-Based Mobile Learning System to Improve Students' Learning Achievements and Motivations in Natural Science Inquiry Activities

    Science.gov (United States)

    Chiang, Tosti H. C.; Yang, Stephen J. H.; Hwang, Gwo-Jen

    2014-01-01

    In this study, an augmented reality-based mobile learning system is proposed for conducting inquiry-based learning activities. An experiment has been conducted to examine the effectiveness of the proposed approach in terms of learning achievements and motivations. The subjects were 57 fourth graders from two classes taught by the same teacher in…

  14. Enhancing the Learning Achievements and Attitudes of Taiwan Vocational School Students in Accounting with the Dynamic Assessment System

    Science.gov (United States)

    Shih, Ju-Ling; Ku, David Tawei; Hung, Su-Huan

    2013-01-01

    We investigate how the computerized dynamic assessment system improves the learning achievements of vocational high school students studying accounting. Our experiment was conducted under the one-group pretest-posttest design of 34 junior students. The questionnaire results were analyzed to determine student-learning attitudes and reactions toward…

  15. The Impact of the College Assistance Migrant Program on Migrant Student Academic Achievement in the California State University System

    Science.gov (United States)

    Ramirez, Adrian D.

    2012-01-01

    The 7-year longitudinal study examined the College Assistance Migrant Program (CAMP) impact on migrant student achievement in the California State University system. Participants included migrant students, Latinos, and general student populations from 2002-2009. The analysis of variance and chi-square test of independence were used to explore…

  16. The Use of a Mobile Learning Management System at an Online University and Its Effect on Learning Satisfaction and Achievement

    Directory of Open Access Journals (Sweden)

    Won Sug Shin

    2015-06-01

    Full Text Available This study investigates online students’ acceptance of mobile learning and its influence on learning achievement using an information system success and extended technology acceptance model (TAM. Structural equation modeling was used to test the structure of individual, social, and systemic factors influencing mobile learning’s acceptance, and how said acceptance influences learning satisfaction and achievement. Unlike earlier TAM-related research that did not provide a broad view of technological acceptance and its impact on learning activities, the present study’s results highlight the relationship between behavioral intention/learning satisfaction and learning achievement. Additionally, this study tests the theoretical model of successful mobile learning by empirically accepting mobile learning management systems. The findings further imply that students at online universities have started to accept mobile technology as a new learning tool; consequently, its acceptance has influenced their learning achievement both directly and indirectly. These discoveries should facilitate a better understanding of students’ usage of mobile learning systems in higher education, and provide timely guidance for its development and implementation.

  17. Report on achievements in fiscal 1999. Development of technology to put photovoltaic power generation system for industrial use into practical use (Summary of comprehensive achievement); 1999 nendo sangyoyonado solar system jitsuyoka gijutsu kaihatsu seika hokokusho. Kenkyu kaihatsu kanri

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-09-01

    NEDO is proceeding with the development of a technology to put photovoltaic power generation system for industrial use into practical use, with an aim of simultaneous solution of sustainable growth and environmental problems. In developing an advanced heat process type system, selection was made on high-performance refrigeration materials for a stand-alone type refrigeration system capable of dealing with levels of minus 20 degrees C or lower (Ti-Ni-Zr-Mn-V based hydrogen absorbing alloys for use at low temperatures, and La-Ni-Sn-Al based hydrogen absorbing alloys for regeneration use). Evaluations were given on the developed refrigeration system by using the dynamic property simulation technology. The developed system achieved a cold heat acquiring temperature of minus 20 degrees or lower, and a heat output of 1,500 kcal/hr or more under the conditions of outside air temperature of 28 degrees C, and collected solar heat temperature of 140 degrees C. CO2 reduction unit requirement was calculated from LCA on a solar heat utilization system with which the future technological development is expected to aim at. Themes proposed to be promoted in the future would include a direct heat utilization system such as the building material integrated system, a freezing and refrigeration system, a high-temperature light and heat collecting system, a harmful substance analyzing system, a high temperature utilizing fuel synthesizing system, a high-efficiency heat storing system, and a snowy cold region system. (NEDO)

  18. Monitoring operating temperature and supply voltage in achieving high system dependability

    NARCIS (Netherlands)

    Khan, M.A.; Kerkhoff, Hans G.

    2013-01-01

    System dependability being a set of number of attributes, of which the important reliability, heavily depends on operating temperature and supply voltage. Any change beyond the designed specifications may change the system performance and could result in system reliability and hence dependability

  19. Method for achieving hydraulic balance in typical Chinese building heating systems by managing differential pressure and flow

    DEFF Research Database (Denmark)

    Zhang, Lipeng; Xia, Jianjun; Thorsen, Jan Eric

    2017-01-01

    to a lack of pressure and flow control. This study investigated using pre-set radiator valves combined with differential pressure (DP) controllers to achieve hydraulic balance in building distribution systems, and consequently save energy and reduce the emissions. We considered a multi-storey building......Hydraulic unbalance is a common problem in Chinese district heating (DH) systems. Hydraulic unbalance has resulted in poor flow distribution among heating branches and overheating of apartments. Studies show that nearly 30% of the total heat supply is being wasted in Chinese DH systems due...... modelled in the IDA-ICE software, along with a self-developed mathematical hydraulic model to simulate its heat performance and hydraulic performance with various control scenarios. In contrast to the situation with no pressure or flow control, this solution achieves the required flow distribution...

  20. Achieving control and interoperability through unified model-based systems and software engineering

    Science.gov (United States)

    Rasmussen, Robert; Ingham, Michel; Dvorak, Daniel

    2005-01-01

    Control and interoperation of complex systems is one of the most difficult challenges facing NASA's Exploration Systems Mission Directorate. An integrated but diverse array of vehicles, habitats, and supporting facilities, evolving over the long course of the enterprise, must perform ever more complex tasks while moving steadily away from the sphere of ground support and intervention.

  1. Achieving Better Buying Power for Mobile Open Architecture Software Systems Through Diverse Acquisition Scenarios

    Science.gov (United States)

    2016-04-30

    largest acquirers of commodity and bespoke (custom) software systems. The Defense community further extends its reach and influence on a global basis...information system applications that support modern military operations at a regional, national, or global level. These applications may be focused to...alternatives for costing or charging for software that include franchising ; enterprise licensing; metered usage; advertising supported; subscription

  2. Component-based architecting for distributed real-time systems : how to achieve composability?

    NARCIS (Netherlands)

    Hammer, D.K.; Aksit, M.

    2001-01-01

    In systems- and software architecting, architecture can be viewed as a highlevel design that supports the construction of ICT-systems. Starting from a list of general requirements, the first part of this chapter gives an overview of the dimensions of such a design. In addition, the various, often

  3. A System for Planning and Achieving Comprehensive Health Care in Residential Institutions for the Mentally Retarded.

    Science.gov (United States)

    Decker, Harold A.

    Based on a view of health care intertwining medicine intimately with other components of institutional care, the monograph presents a system of concepts and operating techniques for providing comprehensive health care to institutionalized retardates. Background of the system is explained in terms of its research basis (two studies by the author of…

  4. The Rapid Transit System That Achieves Higher Performance with Lower Life-Cycle Costs

    Science.gov (United States)

    Sone, Satoru; Takagi, Ryo

    In the age of traction system made of inverter and ac traction motors, distributed traction system with pure electric brake of regenerative mode has been recognised very advantageous. This paper proposes a new system as the lowest life-cycle cost system for high performance rapid transit, a new architecture and optimum parameters of power feeding system, and a new running method of trains. In Japan, these components of this proposal, i.e. pure electric brake and various countermeasures of reducing loss of regeneration have been already popular but not as yet the new running method for better utilisation of the equipment and for lower life-cycle cost. One example of what are proposed in this paper will be made as Tsukuba Express, which is under construction as the most modern commuter railway in Greater Tokyo area.

  5. Robotic Observatory System Design-Specification Considerations for Achieving Long-Term Sustainable Precision Performance

    Science.gov (United States)

    Wray, J. D.

    2003-05-01

    The robotic observatory telescope must point precisely on the target object, and then track autonomously to a fraction of the FWHM of the system PSF for durations of ten to twenty minutes or more. It must retain this precision while continuing to function at rates approaching thousands of observations per night for all its years of useful life. These stringent requirements raise new challenges unique to robotic telescope systems design. Critical design considerations are driven by the applicability of the above requirements to all systems of the robotic observatory, including telescope and instrument systems, telescope-dome enclosure systems, combined electrical and electronics systems, environmental (e.g. seeing) control systems and integrated computer control software systems. Traditional telescope design considerations include the effects of differential thermal strain, elastic flexure, plastic flexure and slack or backlash with respect to focal stability, optical alignment and angular pointing and tracking precision. Robotic observatory design must holistically encapsulate these traditional considerations within the overall objective of maximized long-term sustainable precision performance. This overall objective is accomplished through combining appropriate mechanical and dynamical system characteristics with a full-time real-time telescope mount model feedback computer control system. Important design considerations include: identifying and reducing quasi-zero-backlash; increasing size to increase precision; directly encoding axis shaft rotation; pointing and tracking operation via real-time feedback between precision mount model and axis mounted encoders; use of monolithic construction whenever appropriate for sustainable mechanical integrity; accelerating dome motion to eliminate repetitive shock; ducting internal telescope air to outside dome; and the principal design criteria: maximizing elastic repeatability while minimizing slack, plastic deformation

  6. How Can a Global Social Support System Hope to Achieve Fairer Competiveness?

    Science.gov (United States)

    Goldblatt, Peter

    2016-01-01

    Ooms et al sets out some good general principles for a global social support system to improve fairer global competitiveness as a result of redistribution. This commentary sets out to summarize some of the conditions that would need to be satisfied for it to level up gradients in inequality through such a social support system, using the National Basketball Association (NBA) example as a point of reference. From this, the minimal conditions are described that would be required for the support system, proposed in the article by Ooms et al, to succeed. PMID:26927594

  7. Supramolecular effects in dendritic systems containing photoactive groups

    Directory of Open Access Journals (Sweden)

    GIANLUCA CAMILLO AZZELLINI

    2000-03-01

    Full Text Available In this article are described dendritic structures containing photoactive groups at the surface or in the core. The observed supramolecular effects can be attributed to the nature of the photoactive group and their location in the dendritic architecture. The peripheric azobenzene groups in these dendrimeric compounds can be regarded as single residues that retain the spectroscopic and photochemical properties of free azobenzene moiety. The E and Z forms of higher generation dendrimer, functionalized with azobenzene groups, show different host ability towards eosin dye, suggesting the possibility of using such dendrimer in photocontrolled host-guest systems. The photophysical properties of many dendritic-bipyridine ruthenium complexes have been investigated. Particularly in aerated medium more intense emission and a longer excited-state lifetime are observed as compared to the parent unsubstituted bipyridine ruthenium complexes. These differences can be attributed to a shielding effect towards dioxygen quenching originated by the dendritic branches.

  8. Achieving Synchronization in Arrays of Coupled Differential Systems with Time-Varying Couplings

    Directory of Open Access Journals (Sweden)

    Xinlei Yi

    2013-01-01

    Full Text Available We study complete synchronization of the complex dynamical networks described by linearly coupled ordinary differential equation systems (LCODEs. Here, the coupling is timevarying in both network structure and reaction dynamics. Inspired by our previous paper (Lu et al. (2007-2008, the extended Hajnal diameter is introduced and used to measure the synchronization in a general differential system. Then we find that the Hajnal diameter of the linear system induced by the time-varying coupling matrix and the largest Lyapunov exponent of the synchronized system play the key roles in synchronization analysis of LCODEs with identity inner coupling matrix. As an application, we obtain a general sufficient condition guaranteeing directed time-varying graph to reach consensus. Example with numerical simulation is provided to show the effectiveness of the theoretical results.

  9. ACHIEVING MISSION ASSURANCE AGAINST A CYBER THREAT WITH THE DEFENSE ACQUISITION SYSTEM

    Science.gov (United States)

    2016-02-13

    assurance to be “ baked in” to system design. Second, FMAs and vulnerability assessments should be conducted prior to every acquisition milestone...Before this guidance, most direction seemed to be biased toward addressing network IT rather than the systems and software characteristic of weapon...vulnerability assessments, it failed to mandate three important characteristics . First, the requirement for execution of an FMA was missing. The

  10. Achieving Lights-Out Operation of SMAP Using Ground Data System Automation

    Science.gov (United States)

    Sanders, Antonio

    2013-01-01

    The approach used in the SMAP ground data system to provide reliable, automated capabilities to conduct unattended operations has been presented. The impacts of automation on the ground data system architecture were discussed, including the three major automation patterns identified for SMAP and how these patterns address the operations use cases. The architecture and approaches used by SMAP will set the baseline for future JPL Earth Science missions.

  11. Is sustainability achievable? Exploring the limits of sustainability with model systems.

    Science.gov (United States)

    Shastri, Yogendra; Diwekar, Urmila; Cabezas, Heriberto; Williamson, James

    2008-09-01

    Successful implementation of sustainability ideas in ecosystem management requires a basic understanding of the often nonlinear and nonintuitive relationships among different dimensions of sustainability, particularly the system-wide implications of human actions. This basic understanding further includes a sense of the time scale of possible future events and the limits of what is and is not likely to be possible. With this understanding, systematic approaches can then be used to develop policy guidelines for the system. This article presents an illustration of these ideas by analyzing an integrated ecological-economic-social model, which comprises various ecological (natural) and domesticated compartments representing species along with a macroeconomic price setting model. The stable and qualitatively realistic model is used to analyze different relevant scenarios. Apart from highlighting complex relationships within the system, it identifies potentially unsustainable future developments such as increased human per capita consumption rates. Dynamic optimization is then used to develop time-dependent policy guidelines for the unsustainable scenarios using objective functions that aim to minimize fluctuations in the system's Fisher information. The results can help to identify effective policy parameters and highlight the tradeoff between natural and domesticated compartments while managing such integrated systems. The results should also qualitatively guide further investigations in the area of system level studies and policy development.

  12. Development of tritium plant system for fusion reactors. Achievements in the 14-year US-Japan collaboration

    International Nuclear Information System (INIS)

    Nishi, Masataka; Yamanishi, Toshihiko; Shu, Wataru

    2003-01-01

    Fuel processing technology and tritium safe-handling technology have been developed through US/DOE-JAERI collaboration from 1987 till 2001, and the technologies to construct the tritium plant system of ITER have been made currently available. This paper overviews the major achievements of this collaborative researches over fourteen years, which were performed mainly at the Tritium Systems Test Assembly (TSTA) of the Los Alamos National Laboratory (LANL). The tritium plant system consists mainly of a fuel processing system, which includes a fuel cycle system and a blanket tritium recovery system, and a tritium confinement/removal system. The fuel cycle system recovers fuel from plasma exhaust gas and recycles it. In the collaboration, major key components and subsystems were developed, and the performance of the integrated system was successfully demonstrated over its one-month operation in which plasma exhaust model gas was processed at a processing rate of up to 1/6 level of the ITER. The technological basis of the fuel cycle system was thus established. Blanket tritium recovery technology was also successfully demonstrated using the TSTA system. Through the successful safe-operation of the TSTA, reliability of tritium confinement/removal system was verified basically. In addition, much data to confirm or enhance safety were accumulated by experiments such as intentional tritium release in a large room. Furthermore, distribution of tritium contamination in the vacuum vessel of the TFTR, a large tokamak of the Princeton Plasma Physics Laboratory (PPPL), was investigated in this work. (author)

  13. Development of Tritium Plant System for Fusion Reactors - Achievements in the 14-year US-Japan Collaboration -

    Science.gov (United States)

    Nishi, Masataka; Yamanishi, Toshihiko; Shu, Wataru

    Fuel processing technology and tritium safe-handling technology have been developed through US/DOE-JAERI collaboration from 1987 till 2001, and the technologies to construct the tritium plant system of ITER have been made currently available. This paper overviews the major achievements of this collaborative researches over fourteen years, which were performed mainly at the Tritium Systems Test Assembly (TSTA) of the Los Alamos National Laboratory (LANL). The tritium plant system consists mainly of a fuel processing system, which includes a fuel cycle system and a blanket tritium recovery system, and a tritium confinement/removal system. The fuel cycle system recovers fuel from plasma exhaust gas and recycles it. In the collaboration, major key components and subsystems were developed, and the performance of the integrated system was successfully demonstrated over its one-month operation in which plasma exhaust model gas was processed at a processing rate of up to 1/6 level of the ITER. The technological basis of the fuel cycle system was thus established. Blanket tritium recovery technology was also successfully demonstrated using the TSTA system. Through the successful safeoperation of the TSTA, reliability of tritium confinement/removal system was verified basically. In addition, much data to confirm or enhance safety were accumulated by experiments such as intentional tritium release in a large room. Furthermore,distribution of tritium contamination in the vacuum vessel of the TFTR, a large tokamak of the Princeton Plasma Physics Laboratory (PPPL), was investigated in this work.

  14. Effect of Potassium Chlorate on the Treatment of Domestic Sewage by Achieving Shortcut Nitrification in a Constructed Rapid Infiltration System.

    Science.gov (United States)

    Fang, Qinglin; Xu, Wenlai; Yan, Zhijiao; Qian, Lei

    2018-04-04

    A constructed rapid infiltration (CRI) system is a new type of sewage biofilm treatment technology, but due to its anaerobic zone it lacks the carbon sources and the conditions for nitrate retention, and its nitrogen removal performance is very poor. However, a shortcut nitrification–denitrification process presents distinctive advantages, as it saves oxygen, requires less organic matter, and requires less time for denitrification compared to conventional nitrogen removal methods. Thus, if the shortcut nitrification–denitrification process could be applied to the CRI system properly, a simpler, more economic, and efficient nitrogen removal method will be obtained. However, as its reaction process shows that the first and the most important step of achieving shortcut nitrification–denitrification is to achieve shortcut nitrification, in this study we explored the feasibility to achieve shortcut nitrification, which produces nitrite as the dominant nitrogen species in effluent, by the addition of potassium chlorate (KClO₃) to the influent. In an experimental CRI test system, the effects on nitrogen removal, nitrate inhibition, and nitrite accumulation were studied, and the advantages of achieving a shortcut nitrification–denitrification process were also analysed. The results showed that shortcut nitrification was successfully achieved and maintained in a CRI system by adding 5 mM KClO₃ to the influent at a constant pH of 8.4. Under these conditions, the nitrite accumulation percentage was increased, while a lower concentration of 3 mM KClO₃ had no obvious effect. The addition of 5mM KClO₃ in influent presumably inhibited the activity of ammonia-oxidizing bacteria (AOB) and nitrite-oxidizing bacteria (NOB), but inhibition of nitrite-oxidizing bacteria (NOB) was so strong that it resulted in a maximum nitrite accumulation percentage of up to over 80%. As a result, nitrite became the dominant nitrogen product in the effluent. Moreover, if the shortcut

  15. Effect of Potassium Chlorate on the Treatment of Domestic Sewage by Achieving Shortcut Nitrification in a Constructed Rapid Infiltration System

    Directory of Open Access Journals (Sweden)

    Qinglin Fang

    2018-04-01

    Full Text Available A constructed rapid infiltration (CRI system is a new type of sewage biofilm treatment technology, but due to its anaerobic zone it lacks the carbon sources and the conditions for nitrate retention, and its nitrogen removal performance is very poor. However, a shortcut nitrification–denitrification process presents distinctive advantages, as it saves oxygen, requires less organic matter, and requires less time for denitrification compared to conventional nitrogen removal methods. Thus, if the shortcut nitrification–denitrification process could be applied to the CRI system properly, a simpler, more economic, and efficient nitrogen removal method will be obtained. However, as its reaction process shows that the first and the most important step of achieving shortcut nitrification–denitrification is to achieve shortcut nitrification, in this study we explored the feasibility to achieve shortcut nitrification, which produces nitrite as the dominant nitrogen species in effluent, by the addition of potassium chlorate (KClO3 to the influent. In an experimental CRI test system, the effects on nitrogen removal, nitrate inhibition, and nitrite accumulation were studied, and the advantages of achieving a shortcut nitrification–denitrification process were also analysed. The results showed that shortcut nitrification was successfully achieved and maintained in a CRI system by adding 5 mM KClO3 to the influent at a constant pH of 8.4. Under these conditions, the nitrite accumulation percentage was increased, while a lower concentration of 3 mM KClO3 had no obvious effect. The addition of 5mM KClO3 in influent presumably inhibited the activity of ammonia-oxidizing bacteria (AOB and nitrite-oxidizing bacteria (NOB, but inhibition of nitrite-oxidizing bacteria (NOB was so strong that it resulted in a maximum nitrite accumulation percentage of up to over 80%. As a result, nitrite became the dominant nitrogen product in the effluent. Moreover, if the

  16. A computational approach to achieve situational awareness from limited observations of a complex system

    Science.gov (United States)

    Sherwin, Jason

    At the start of the 21st century, the topic of complexity remains a formidable challenge in engineering, science and other aspects of our world. It seems that when disaster strikes it is because some complex and unforeseen interaction causes the unfortunate outcome. Why did the financial system of the world meltdown in 2008--2009? Why are global temperatures on the rise? These questions and other ones like them are difficult to answer because they pertain to contexts that require lengthy descriptions. In other words, these contexts are complex. But we as human beings are able to observe and recognize this thing we call 'complexity'. Furthermore, we recognize that there are certain elements of a context that form a system of complex interactions---i.e., a complex system. Many researchers have even noted similarities between seemingly disparate complex systems. Do sub-atomic systems bear resemblance to weather patterns? Or do human-based economic systems bear resemblance to macroscopic flows? Where do we draw the line in their resemblance? These are the kinds of questions that are asked in complex systems research. And the ability to recognize complexity is not only limited to analytic research. Rather, there are many known examples of humans who, not only observe and recognize but also, operate complex systems. How do they do it? Is there something superhuman about these people or is there something common to human anatomy that makes it possible to fly a plane? Or to drive a bus? Or to operate a nuclear power plant? Or to play Chopin's etudes on the piano? In each of these examples, a human being operates a complex system of machinery, whether it is a plane, a bus, a nuclear power plant or a piano. What is the common thread running through these abilities? The study of situational awareness (SA) examines how people do these types of remarkable feats. It is not a bottom-up science though because it relies on finding general principles running through a host of varied

  17. In place of fear: aligning health care planning with system objectives to achieve financial sustainability.

    Science.gov (United States)

    Birch, Stephen; Murphy, Gail Tomblin; MacKenzie, Adrian; Cumming, Jackie

    2015-04-01

    The financial sustainability of publicly funded health care systems is a challenge to policymakers in many countries as health care absorbs an ever increasing share of both national wealth and government spending. New technology, aging populations and increasing public expectations of the health care system are often cited as reasons why health care systems need ever increasing funding as well as reasons why universal and comprehensive public systems are unsustainable. However, increases in health care spending are not usually linked to corresponding increases in need for care within populations. Attempts to promote financial sustainability of systems such as limiting the range of services is covered or the groups of population covered may compromise their political sustainability as some groups are left to seek private cover for some or all services. In this paper, an alternative view of financial sustainability is presented which identifies the failure of planning and management of health care to reflect needs for care in populations and to integrate planning and management functions for health care expenditure, health care services and the health care workforce. We present a Health Care Sustainability Framework based on disaggregating the health care expenditure into separate planning components. Unlike other approaches to planning health care expenditure, this framework explicitly incorporates population health needs as a determinant of health care requirements, and provides a diagnostic tool for understanding the sources of expenditure increase. © The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

  18. Capacity Estimation and Near-Capacity Achieving Techniques for Digitally Modulated Communication Systems

    DEFF Research Database (Denmark)

    Yankov, Metodi Plamenov

    investigation will include linear interference channels of high dimensionality (such as multiple-input multiple-output), and the non-linear optical fiber channel, which has been gathering more and more attention from the information theory community in recent years. In both cases novel CCC estimates and lower......This thesis studies potential improvements that can be made to the current data rates of digital communication systems. The physical layer of the system will be investigated in band-limited scenarios, where high spectral efficiency is necessary in order to meet the ever-growing data rate demand....... Several issues are tackled, both with theoretical and more practical aspects. The theoretical part is mainly concerned with estimating the constellation constrained capacity (CCC) of channels with discrete input, which is an inherent property of digital communication systems. The channels under...

  19. Solving Disparities Through Payment And Delivery System Reform: A Program To Achieve Health Equity.

    Science.gov (United States)

    DeMeester, Rachel H; Xu, Lucy J; Nocon, Robert S; Cook, Scott C; Ducas, Andrea M; Chin, Marshall H

    2017-06-01

    Payment systems generally do not directly encourage or support the reduction of health disparities. In 2013 the Finding Answers: Solving Disparities through Payment and Delivery System Reform program of the Robert Wood Johnson Foundation sought to understand how alternative payment models might intentionally incorporate a disparities-reduction component to promote health equity. A qualitative analysis of forty proposals to the program revealed that applicants generally did not link payment reform tightly to disparities reduction. Most proposed general pay-for-performance, global payment, or shared savings plans, combined with multicomponent system interventions. None of the applicants proposed making any financial payments contingent on having successfully reduced disparities. Most applicants did not address how they would optimize providers' intrinsic and extrinsic motivation to reduce disparities. A better understanding of how payment and care delivery models might be designed and implemented to reduce health disparities is essential. Project HOPE—The People-to-People Health Foundation, Inc.

  20. Efficiency achievements from a user-developed real-time modifiable clinical information system.

    Science.gov (United States)

    Bishop, Roderick O; Patrick, Jon; Besiso, Ali

    2015-02-01

    This investigation was initiated after the introduction of a new information system into the Nepean Hospital Emergency Department. A retrospective study determined that the problems introduced by the new system led to reduced efficiency of the clinical staff, demonstrated by deterioration in the emergency department's (ED's) performance. This article is an investigation of methods to improve the design and implementation of clinical information systems for an ED by using a process of clinical team-led design and a technology built on a radically new philosophy denoted as emergent clinical information systems. The specific objectives were to construct a system, the Nepean Emergency Department Information Management System (NEDIMS), using a combination of new design methods; determine whether it provided any reduction in time and click burden on the user in comparison to an enterprise proprietary system, Cerner FirstNet; and design and evaluate a model of the effect that any reduction had on patient throughput in the department. The methodology for conducting a direct comparison between the 2 systems used the 6 activity centers in the ED of clerking, triage, nursing assessments, fast track, acute care, and nurse unit manager. A quantitative study involved the 2 systems being measured for their efficiency on 17 tasks taken from the activity centers. A total of 332 task instances were measured for duration and number of mouse clicks in live usage on Cerner FirstNet and in reproduction of the same Cerner FirstNet work on NEDIMS as an off-line system. The results showed that NEDIMS is at least 41% more efficient than Cerner FirstNet (95% confidence interval 21.6% to 59.8%). In some cases, the NEDIMS tasks were remodeled to demonstrate the value of feedback to create improvements and the speed and economy of design revision in the emergent clinical information systems approach. The cost of the effort in remodeling the designs showed that the time spent on remodeling is

  1. Achieving Ultra-Reliable Low-Latency Communications: Challenges and Envisioned System Enhancements

    DEFF Research Database (Denmark)

    Pocovi Gerardino, Guillermo Andres; Shariatmadari, Hamidreza; Berardinelli, Gilberto

    2018-01-01

    URLLC have the potential to enable a new range of applications and services: from wireless control and automation in industrial environments to self-driving vehicles. 5G wireless systems are faced by different challenges for supporting URLLC. Some of the challenges, particularly in the downlink......-of-the-art solutions covering different aspects of the radio interface. In addition, system-level simulation results are presented, showing how the proposed techniques can work in harmony in order to fulfill the ambitious latency and reliability requirements of upcoming URLLC applications....

  2. Reinforcement course. Future nuclear power systems. A way to achieve more acceptance?

    International Nuclear Information System (INIS)

    Rey, Matthias

    2013-01-01

    The 2012 Reinforcement Course organized by the Swiss Nuclear Forum was devoted to the question in what way nuclear reactors of the third generation and more recent concepts provide more safety, and whether this is a way to achieve more societal acceptance. Besides presentations by speakers from industry and science, also theological, psychological, political and sociological views about nuclear power were expressed. Dr. Urs Weidmann, President of the Committee on Education of the Swiss Nuclear Forum, Head of the Beznau Nuclear Power Plant, Axpo AG, opened the course to approximately 120 participants by introducing the first six presentations, which dealt with societal aspects of nuclear power. The second group of three papers were introduced by Dr. Philipp Haenggi, Head of the Swiss nuclear office. The subject was 'Future Concepts - Design Regulations and Safety Considerations.' The agenda of the second day featured 'Third-generation Reactors in the Light of Fukushima' and 'Sideviews' of subjects and future technologies discussed by society in a similarly controversial way. Dr. Johannis Noeggerath, Head of Nuclear Safety, Leibstadt Nuclear Power Plant, guided the participants through the eight papers. The next reinforcement course will again be held in Olten on November 19 and 20, 2013, and will be devoted to lifetime management of nuclear power plants. (orig.)

  3. Achieving Better Buying Power Through Acquisition of Open Architecture Software Systems for Web-Based and Mobile Devices

    Science.gov (United States)

    2015-04-30

    realizing Better Buying Power ( BPP ) goals for lowering system costs, achieving technical excellence, enabling innovation, and advancing the...automated assistance to track and manage oversight of policy compliance (e.g., for alignment with BPP and cybersecurity assessment). Without automated...forward, there is potential interest in seeing the BPP initiative evolve to also address risk as an implicit cost driver. This might allow for

  4. Achieving universal health coverage in South Africa through a district health system approach: conflicting ideologies of health care provision.

    Science.gov (United States)

    Fusheini, Adam; Eyles, John

    2016-10-07

    Universal Health Coverage (UHC) has emerged as a major goal for health care delivery in the post-2015 development agenda. It is viewed as a solution to health care needs in low and middle countries with growing enthusiasm at both national and global levels. Throughout the world, however, the paths of countries to UHC have differed. South Africa is currently reforming its health system with UHC through developing a national health insurance (NHI) program. This will be practically achieved through a decentralized approach, the district health system, the main vehicle for delivering services since democracy. We utilize a review of relevant documents, conducted between September 2014 and December 2015 of district health systems (DHS) and UHC and their ideological underpinnings, to explore the opportunities and challenges, of the district health system in achieving UHC in South Africa. Review of data from the NHI pilot districts suggests that as South Africa embarks on reforms toward UHC, there is a need for a minimal universal coverage and emphasis on district particularity and positive discrimination so as to bridge health inequities. The disparities across districts in relation to health profiles/demographics, health delivery performance, management of health institutions or district management capacity, income levels/socio-economic status and social determinants of health, compliance with quality standards and above all the burden of disease can only be minimised through positive discrimination by paying more attention to underserved and disadavantaged communities. We conclude that in South Africa the DHS is pivotal to health reform and UHC may be best achieved through minimal universal coverage with positive discrimination to ensure disparities across districts in relation to disease burden, human resources, financing and investment, administration and management capacity, service readiness and availability and the health access inequalities are consciously

  5. Achieving semantic interoperability in multi-agent systems: A dialogue-based approach

    NARCIS (Netherlands)

    Diggelen, J. van

    2007-01-01

    Software agents sharing the same ontology can exchange their knowledge fluently as their knowledge representations are compatible with respect to the concepts regarded as relevant and with respect to the names given to these concepts. However, in open heterogeneous multi-agent systems, this scenario

  6. The L2 Motivational Self System and L2 Achievement: A Study of Saudi EFL Learners

    Science.gov (United States)

    Moskovsky, Christo; Assulaimani, Turki; Racheva, Silvia; Harkins, Jean

    2016-01-01

    The research reported in this article explores the relationship between Dörnyei's (2005, 2009) Second Language Motivational Self System (L2MSS) and the L2 proficiency level of Saudi learners of English as a foreign language (EFL). Male and female participants (N = 360) responded to a questionnaire relating to the main components of L2MSS, the…

  7. Achievements and Lessons Learned from Vietnam's Higher Education Quality Assurance System after a Decade of Establishment

    Science.gov (United States)

    Nguyen, Huu Cuong; Ta, Thi Thu Hien; Nguyen, Thi Thu Huong

    2017-01-01

    Higher education quality assurance and accreditation were officially implemented in Vietnam over twelve years ago. From a totally centralized model, Vietnam's accreditation system has been becoming more independent, especially with the establishment of accrediting agencies. The first accreditation certificates were also awarded to universities…

  8. Guidelines to achieve seals with minimal leak rates for HWR-NPR coolant system components

    International Nuclear Information System (INIS)

    Finn, P.A.

    1991-03-01

    Seal design practices that are acceptable in pressurized-water and boiling-water reactors in the United States are not usable for the Heavy Water Reactor-New Production Reactor (HWR-NPR) because of the stringent requirement on tritium control for the atmosphere within its containment building. To maintain an atmosphere in which workers do not need protective equipment, the components of the coolant system must have a cumulative leak rate less than 0.00026 L/s. Existing technology for seal systems was reviewed with regard to flange, elastomer, valve, and pump design. A technology data base for the designers of the HWR-NPR coolant system was derived from operating experience and seal development work on reactors in the United States, Canada, and Europe. This data base was then used to generate guidelines for the design of seals and/or joints for the HWR-NPR coolant system. Also discussed are needed additional research and development, as well as the necessary component qualification tests for an effective quality control program. 141 refs., 21 figs., 14 tabs

  9. Rooftop photovoltaic (PV) systems for industrial halls: Achieving economic benefit via lowering energy demand

    NARCIS (Netherlands)

    Lee, B.; Trcka, M.; Hensen, J.L.M.

    2012-01-01

    Industrial halls are characterized with their relatively high roof-to-floor ratio, which facilitates ready deployment of renewable energy generation, such as photovoltaic (PV) systems, on the rooftop. To promote deployment of renewable energy generation, feed-in tariff (FIT) higher than the

  10. Effectiveness of Student Response Systems in Terms of Learning Environment, Attitudes and Achievement

    Science.gov (United States)

    Cohn, Stephen T.; Fraser, Barry J.

    2016-01-01

    In order to investigate the effectiveness of using Student Response Systems (SRS) among grade 7 and 8 science students in New York, the How Do You Feel About This Class? (HDYFATC) questionnaire was administered to 1097 students (532 students did use SRS and 565 students who did not use SRS). Data analyses attested to the sound factorial validity…

  11. Controlled biomass removal - the key parameter to achieve enhanced biological phosphorus removal in biofilm systems

    DEFF Research Database (Denmark)

    Morgenroth, E.

    1999-01-01

    the influence of the following processes on EBPR in biofilms was evaluated: (1) mass transfer limitation for oxygen (2) mass transfer limitation for organic substrate, (3) lack of controlled removal of biomass from the system. It was shown that mass transfer of soluble components (oxygen and organic substrate...

  12. Guidelines to achieve seals with minimal leak rates for HWR-NPR coolant system components

    Energy Technology Data Exchange (ETDEWEB)

    Finn, P.A.

    1991-03-01

    Seal design practices that are acceptable in pressurized-water and boiling-water reactors in the United States are not usable for the Heavy Water Reactor-New Production Reactor (HWR-NPR) because of the stringent requirement on tritium control for the atmosphere within its containment building. To maintain an atmosphere in which workers do not need protective equipment, the components of the coolant system must have a cumulative leak rate less than 0.00026 L/s. Existing technology for seal systems was reviewed with regard to flange, elastomer, valve, and pump design. A technology data base for the designers of the HWR-NPR coolant system was derived from operating experience and seal development work on reactors in the United States, Canada, and Europe. This data base was then used to generate guidelines for the design of seals and/or joints for the HWR-NPR coolant system. Also discussed are needed additional research and development, as well as the necessary component qualification tests for an effective quality control program. 141 refs., 21 figs., 14 tabs.

  13. Improving Achievement for Linguistically and Culturally Diverse Learners through an Inquiry-Based Earth Systems Curriculum

    Science.gov (United States)

    Lambert, Julie; Ariza, Eileen N. Whelan

    2008-01-01

    This report describes an inquiry-based Earth systems curriculum and strategies for teaching diverse students, which were embedded in the curriculum. The curriculum was implemented with 5th-grade students with varied linguistic, cultural, and socioeconomic backgrounds in five schools in a large, southeastern U.S., urban school district. At the end…

  14. THE USE OF ELECTRONIC JOURNALS IN SCORE RATING ACCOUNTING SYSTEM OF EDUCATIONAL ACHIEVEMENTS OF STUDENTS

    Directory of Open Access Journals (Sweden)

    И Н Куринин

    2016-12-01

    Full Text Available The article describes a method of using electronic journals as a tool for efficient organization of teacher’s practical work in conditions of computerization of educational process and the widespread implementation of credit-modular system of educational process organization and grade-rating system for basic educational programs proficiency examination. A version of the electronic journal designed by the authors and realized in the program MS Excel is also presented in the article. An example of a completed “Academic Progress” page of the university educational web portal is discussed. It contains a marked electronic student grade book section and the stated conditions and criteria for grades allocation, according to a 100-point scale.

  15. Achieving nonlinear optical modulation via four-wave mixing in a four-level atomic system

    Science.gov (United States)

    Li, Hai-Chao; Ge, Guo-Qin; Zubairy, M. Suhail

    2018-05-01

    We propose an accessible scheme for implementing tunable nonlinear optical amplification and attenuation via a synergetic mechanism of four-wave mixing (FWM) and optical interference in a four-level ladder-type atomic system. By constructing a cyclic atom-field interaction, we show that two reverse FWM processes can coexist via optical transitions in different branches. In the suitable input-field conditions, strong interference effects between the input fields and the generated FWM fields can be induced and result in large amplification and deep attenuation of the output fields. Moreover, such an optical modulation from enhancement to suppression can be controlled by tuning the relative phase. The quantum system can be served as a switchable optical modulator with potential applications in quantum nonlinear optics.

  16. Possibilities of achieving fusion reaction with a 4{pi} focusing system

    Energy Technology Data Exchange (ETDEWEB)

    Barsanti, G; Barsella, B; Camerini, M; Federighi, U; Musumeci, L; Talini, N [CAMEN., Leghorn (Italy)

    1958-07-01

    The 4{pi} focusing by means of an electromagnetic field is analysed. The following points considered: (a) The general solutions of system for equations of motion of a mass m with charge +e valid for arbitrary initial conditions. This is necessary for the consideration of imperfectly focused primary trajectories, of the effect of collisions in the vicinity of the origin and of ions produced in the neutral gas which diffuses into the reaction chamber. (b) Investigation of the primary ion injection system, of the density of the ions in the chamber and of the energy balance as a matter of principle. (c) The experimental apparatus needed for 4{pi} focusing of deuterons and a sketch of a fusion reactor.

  17. Advanced Monitoring Systems Initiative Project Achievements for Environmental Restoration and Waste Management

    International Nuclear Information System (INIS)

    Hohman, E.H.; Lohrstorfer, C.L.; Venedam, R.J.; Weeks, S.J.; Fannin, C.R.

    2006-01-01

    The Advanced Monitoring Systems Initiative (AMSI) project has been in existence since 2002. In this short time period, AMSI has successfully developed, tested and/or demonstrated over 30 advanced sensors and monitoring systems for applications in environmental restoration, waste management and other areas of national interest. This presentation summarizes the AMSI project, and gives examples of recent successes. The purpose of the presentation is to make Symposium attendees aware of AMSI's capabilities and experience, for possible use in the future. Example successes include the following: - Automated hexavalent chromium (Cr(VI)) monitoring in wells alongside the Columbia River; - Atmospheric chemical sensor array for remote, real-time plume tracking; - Wireless sensor platform for long-term monitoring of subsurface moisture; - Embedded piezo-resistive micro-cantilever (EPM) units for carbon tetrachloride (CCl 4 ) and hydrogen cyanide (HCN) detection; - 'iHistorian' for efficient, real-time data management of chemical releases. (authors)

  18. Achievable Performance of Zero-Delay Variable-Rate Coding in Rate-Constrained Networked Control Systems with Channel Delay

    DEFF Research Database (Denmark)

    Barforooshan, Mohsen; Østergaard, Jan; Stavrou, Fotios

    2017-01-01

    This paper presents an upper bound on the minimum data rate required to achieve a prescribed closed-loop performance level in networked control systems (NCSs). The considered feedback loop includes a linear time-invariant (LTI) plant with single measurement output and single control input. Moreover......, in this NCS, a causal but otherwise unconstrained feedback system carries out zero-delay variable-rate coding, and control. Between the encoder and decoder, data is exchanged over a rate-limited noiseless digital channel with a known constant time delay. Here we propose a linear source-coding scheme...

  19. Achieving Better Buying Power through Acquisition of Open Architecture Software Systems for Web and Mobile Devices

    Science.gov (United States)

    2016-02-22

    user query, a database management system, (like MySQL or Oracle 11) that stores, queries and updates metadata associated with the requested content...5.2 Common technology (e.g., Ozone widget framework, Java ); and 5.3 Shared infrastructure (Joint Information Environment, MPE, ICITE). 5.4 Data...or may not be subject to proprietary IP licenses or “fair use” doctrine (cf. Oracle v. Google, re: Java APIs, now pending before the SCOTUS): 15.1 Use

  20. How to combine human resource management systems and human capital portfolios to achieve superior innovation performance

    OpenAIRE

    Rupietta, Christian; Backes-Gellner, Uschi

    2013-01-01

    Firms generate new knowledge that leads to innovations by recombining existing knowledge sources. A successful recombination depends on both the availability of a knowledge stock (human capital pool) that contains innovation-relevant knowledge and the regulation of the knowledge flow through the application of human resource management practices. However, while human resource theory expects complementarities between both the human capital pool and the human resource management system it does ...

  1. Sustained, Low?Intensity Exercise Achieved by a Dynamic Feeding System Decreases Body Fat in Ponies

    OpenAIRE

    de Laat, M.A.; Hampson, B.A.; Sillence, M.N.; Pollitt, C.C.

    2016-01-01

    Background Obesity in horses is increasing in prevalence and can be associated with insulin insensitivity and laminitis. Current treatment strategies for obesity include dietary restriction and exercise. However, whether exercise alone is effective for decreasing body fat is uncertain. Hypothesis Our hypothesis was that twice daily use of a dynamic feeding system for 3 months would induce sustained, low?intensity exercise thereby decreasing adiposity and improving insulin sensitivity (SI). An...

  2. Effect on student motivation, achievement, and learning behavior through the new homework system

    Science.gov (United States)

    Sadaghiani, Homeyra; Bao, Lei

    2002-10-01

    In our introductory physics courses, we implemented a new homework method, where students are allowed to view the solutions to their assignments before the due date. Through applying this homework system we study students' adaptation to having this type of feedback-in-advance information. In particular, we investigate their motivation in learning physics and study the effectiveness of this method in conjunction with students' motivational level.

  3. An Analysis of Techno-Economic Requirements for MOSAIC CPV Systems to Achieve Cost Competitiveness

    Energy Technology Data Exchange (ETDEWEB)

    Horowitz, Kelsey A [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Cunningham, Daniel [ARPA-E; Zahler, James [ARPA-E

    2017-11-01

    A comprehensive bottom-up cost model has been developed by NREL for ARPAE's MOSAIC micro-concentrator PV program. In this presentation, we use this model to examine the potential competitiveness of MOSAIC systems compared to incumbent technologies in different markets. We also provide an example of how these models can be used by awardees to assess different aspects of their design.

  4. PUCK: An Automated Prompting System for Smart Environments: Towards achieving automated prompting; Challenges involved.

    Science.gov (United States)

    Das, Barnan; Cook, Diane J; Schmitter-Edgecombe, Maureen; Seelye, Adriana M

    2012-10-01

    The growth in popularity of smart environments has been quite steep in the last decade and so has the demand for smart health assistance systems. A smart home-based prompting system can enhance these technologies to deliver in-home interventions to users for timely reminders or brief instructions describing the way a task should be done for successful completion. This technology is in high demand given the desire of people who have physical or cognitive limitations to live independently in their homes. In this paper, with the introduction of the "PUCK" prompting system, we take an approach to automate prompting-based interventions without any predefined rule sets or user feedback. Unlike other approaches, we use simple off-the-shelf sensors and learn the timing for prompts based on real data that is collected with volunteer participants in our smart home test bed. The data mining approaches taken to solve this problem come with the challenge of an imbalanced class distribution that occurs naturally in the data. We propose a variant of an existing sampling technique, SMOTE, to deal with the class imbalance problem. To validate the approach, a comparative analysis with Cost Sensitive Learning is performed.

  5. Energy management information systems : achieving improved energy efficiency : a handbook for managers, engineers and operational staff

    Energy Technology Data Exchange (ETDEWEB)

    Hooke, J.H.; Landry, B.J.; Hart, D. [Natural Resources Canada, Ottawa, ON (Canada). Office of Energy Efficiency

    2004-07-01

    There are many opportunities for industrial and commercial facilities to improve energy efficiency by minimizing waste through process optimization. Large energy users can effectively reduce energy costs, improve profits and reduce greenhouse gas emissions by using computing and control equipment. This book covers all aspects of an Energy Management Information System (EMIS) including metering, data collection, data analysis, reporting and cost benefit analyses. EMIS provides relevant information to businesses that enables them to improve energy performance. EMIS deliverables include early detection of poor performance, support for decision making and effective energy reporting. EMIS also features data storage, calculation of effective targets for energy use and comparative energy consumption. Computer systems can be used to improve business performance in terms of finance, personnel, sales, resource planning, maintenance, process control, design and training. In the 1980s, the Canadian Industry Program for Energy Conservation (CIPEC) developed 2 versions of an energy accounting manual to help industrial, commercial and institutional sectors implement energy-accounting systems. The manual was revised in 1989 and is a useful energy management tool for business and other organizations. The EMIS examples described in this booklet reflect that energy is a variable operating cost, not a fixed overhead charge. 8 tabs., 38 figs.

  6. Redox-mediated dissolution of paramagnetic nanolids to achieve a smart theranostic system

    Science.gov (United States)

    Wang, Aifei; Guo, Mingyi; Wang, Nan; Zhao, Jianyun; Qi, Wenxiu; Muhammad, Faheem; Chen, Liang; Guo, Yingjie; Nguyen, Nam-Trung; Zhu, Guangshan

    2014-04-01

    Manganese oxide (Mn3O4) nanoparticles have recently emerged as a promising T1 contrast agent. In this study, for the first time, we demonstrated an interaction of Mn3O4 with a biological system, and found redox sensitive behavior of these paramagnetic nanoparticles in intracellular reducing environment. Inspired by these findings, we for the first time used this interaction for some therapeutic advantages and designed a versatile mesoporous silica based nanotheranostic system to realize redox-activated enhanced magnetic resonance imaging and responsive anticancer drug delivery. Contrary to previous reports, we firstly prepared high quality amine terminated hydrophilic Mn3O4 nanolids, without using multistep ligand exchange strategies. The resulting water stable and small-sized Mn3O4 nanolids were subsequently used as nanolids to cap drug loaded nanochannels of a porous carrier. Exposure to highly prevalent intracellular reducing environment resulted in the steady-state dissolution of these nanolids and attained an intelligent drug release. Furthermore, the redox receptive dissolution of paramagnetic Mn3O4 nanolids into Mn2+ in turn increases the T1 signal to twofold, providing an added opportunity to even track the feedback of therapy. This study, in addition to simultaneously realizing drug delivery and imaging, also provides a new insight into the fate and interaction of manganese oxide nanoparticles with components of biological systems.Manganese oxide (Mn3O4) nanoparticles have recently emerged as a promising T1 contrast agent. In this study, for the first time, we demonstrated an interaction of Mn3O4 with a biological system, and found redox sensitive behavior of these paramagnetic nanoparticles in intracellular reducing environment. Inspired by these findings, we for the first time used this interaction for some therapeutic advantages and designed a versatile mesoporous silica based nanotheranostic system to realize redox-activated enhanced magnetic resonance

  7. Sustained, Low-Intensity Exercise Achieved by a Dynamic Feeding System Decreases Body Fat in Ponies.

    Science.gov (United States)

    de Laat, M A; Hampson, B A; Sillence, M N; Pollitt, C C

    2016-09-01

    Obesity in horses is increasing in prevalence and can be associated with insulin insensitivity and laminitis. Current treatment strategies for obesity include dietary restriction and exercise. However, whether exercise alone is effective for decreasing body fat is uncertain. Our hypothesis was that twice daily use of a dynamic feeding system for 3 months would induce sustained, low-intensity exercise thereby decreasing adiposity and improving insulin sensitivity (SI). Eight, university-owned, mixed-breed, adult ponies with body condition scores (BCS) ≥5/9 were used. Two treatments ("feeder on" or "feeder off") were administered for a 3-month period by a randomized, crossover design (n = 4/treatment). An interim equilibration period of 6 weeks at pasture separated the 2 study phases. Measurements of body mass (body weight, BCS, cresty neck score [CrNS], and morphometry), body fat (determined before and after the "feeder on" treatment only), triglycerides, and insulin sensitivity (SI; combined glucose-insulin test) were undertaken before and after treatments. The dynamic feeding system induced a 3.7-fold increase in the daily distance travelled (n = 6), compared to with a stationary feeder, which significantly decreased mean BCS (6.53 ± 0.94 to 5.38 ± 1.71), CrNS (2.56 ± 1.12 to 1.63 ± 1.06) and body fat (by 4.95%). An improvement in SI did not occur in all ponies. A dynamic feeding system can be used to induce sustained (daily), low-intensity exercise that promotes weight loss in ponies. However, this exercise may not be sufficient to substantially improve SI. Copyright © 2016 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.

  8. Realigning Shared Governance With Magnet® and the Organization's Operating System to Achieve Clinical Excellence.

    Science.gov (United States)

    Moreno, Janette V; Girard, Anita S; Foad, Wendy

    2018-03-01

    In 2012, an academic medical center successfully overhauled a 15-year-old shared governance to align 6 house-wide and 30 unit-based councils with the new Magnet Recognition Program® and the organization's operating system, using the processes of LEAN methodology. The redesign improved cross-council communication structures, facilitated effective shared decision-making processes, increased staff engagement, and improved clinical outcomes. The innovative structural and process elements of the new model are replicable in other health institutions.

  9. Consideration of the legal system required for achievement of current nuclear power plant construction programmes

    International Nuclear Information System (INIS)

    Castellon Fernandez, E.; Forum Atomico Espanol, Madrid)

    1976-01-01

    The extensive nuclear power plant construction programmes currently in progress in western countries require updating of the legislation in force in this field, especially as regards the following: acquisition of the sites necessary by means of a national planning programme of available sites; simplification of formalities concerning issuance of administrative licenses; revision of the principle of absolute and exclusive liability of the nuclear operator which forms the basis of the third party liability system for nuclear damage; radioactive waste management and decommissioning of nuclear plants. Furthermore, this new legislation should be harmonized between the different countries concerned. (N.E.A.) [fr

  10. Determination of the wind power systems load to achieve operation in the maximum energy area

    Science.gov (United States)

    Chioncel, C. P.; Tirian, G. O.; Spunei, E.; Gillich, N.

    2018-01-01

    This paper analyses the operation of the wind turbine, WT, in the maximum power point, MPP, by linking the load of the Permanent Magnet Synchronous Generator, PMSG, with the wind speed value. The load control methods at wind power systems aiming an optimum performance in terms of energy are based on the fact that the energy captured by the wind turbine significantly depends on the mechanical angular speed of the wind turbine. The presented control method consists in determining the optimal mechanical angular speed, ωOPTIM, using an auxiliary low power wind turbine, WTAUX, operating without load, at maximum angular velocity, ωMAX. The method relies on the fact that the ratio ωOPTIM/ωMAX has a constant value for a given wind turbine and does not depend on the time variation of the wind speed values.

  11. On the possibility to achieve population inversion in a magnetic nanoparticle system

    International Nuclear Information System (INIS)

    Hrianca, Ioan

    2008-01-01

    Based on the fact that an intense magnetic field may group the orientations of easy magnetic axis (e.m.a.) of nanoparticles of a ferrofluid around the field direction, one can state that, by freezing, the grouping remains although the field is absent. By bringing the frozen ferofluid to saturation magnetization in the e.m.a. direction, then followed by the field's effect inversion, a population inversion state is created. Although for nanoparticles with low anisotropy the time of inversion is rather short (10 -5 s), we have proved that for nanoparticles with higher anisotropy, this time can increase, even up to 10 5 s. One can assume that, during the inversion, the particle system represents an active medium for amplipfying electromagnetic radiations in microwaves field

  12. Achievement report for fiscal 1998. Multimedia system for the disabled; 1998 nendo seika hokokusho. Shogaisha taio multimedia system

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-05-01

    Development has been made on the element technologies for a multimedia system for the disabled. In developing the non-visual graphical user interface (GUI) access system, a non-visual access system to enable the visually disabled to access a GUI system by utilizing sound and tactile devices was developed. In developing the three-dimensional sound utilizing information providing system, a system was developed, in which information on screen arrangement of the GUI in a personal computer is presented as spatial sound positions by using the three-dimensional sound control technology. The system can be operated non-visually using a mouse by controlling movements of a cursor. The current fiscal year has improved three-dimensional sound producing devices, three-dimensional sound interface, and how to handle their applications. User evaluations were also performed. Functions were expanded and improved in a system and an optical media reader that enable the visually disabled person to read printed papers by himself. Development was made also on a function to link the system with a total system. (NEDO)

  13. The relationship of learning motivation, achievement and satisfaction for nurses learning simple excel VBA information systems programming.

    Science.gov (United States)

    Lee, Ying Li; Chien, Tsai Feng; Kuo, Ming Chuan; Chang, Polun

    2014-01-01

    This study aims to understand the relationship between participating nurses' motivation, achievement and satisfaction before and after they learned to program in Excel Visual Basic for Applications (Excel VBA). We held a workshop to train nurses in developing simple Excel VBA information systems to support their clinical or administrative practices. Before and after the workshop, the participants were evaluated on their knowledge of Excel VBA, and a questionnaire was given to survey their learning motivation and satisfaction. Statistics softwares Winsteps and SPSS were used for data analysis. Results show that the participants are more knowledgeable about VBA as well as more motivated in learning VBA after the workshop. Participants were highly satisfied with the overall arrangement of the workshop and instructors, but didn't have enough confidence in promoting the application of Excel VBA themselves. In addition, we were unable to predict the participants' achievement by their demographic characteristics or pre-test motivation level.

  14. Achieving organisational competence for clinical leadership: the role of high performance work systems.

    Science.gov (United States)

    Leggat, Sandra G; Balding, Cathy

    2013-01-01

    While there has been substantial discussion about the potential for clinical leadership in improving quality and safety in healthcare, there has been little robust study. The purpose of this paper is to present the results of a qualitative study with clinicians and clinician managers to gather opinions on the appropriate content of an educational initiative being planned to improve clinical leadership in quality and safety among medical, nursing and allied health professionals working in primary, community and secondary care. In total, 28 clinicians and clinician managers throughout the state of Victoria, Australia, participated in focus groups to provide advice on the development of a clinical leadership program in quality and safety. An inductive, thematic analysis was completed to enable the themes to emerge from the data. Overwhelmingly the participants conceptualised clinical leadership in relation to organisational factors. Only four individual factors, comprising emotional intelligence, resilience, self-awareness and understanding of other clinical disciplines, were identified as being important for clinical leaders. Conversely seven organisational factors, comprising role clarity and accountability, security and sustainability for clinical leaders, selective recruitment into clinical leadership positions, teamwork and decentralised decision making, training, information sharing, and transformational leadership, were seen as essential, but the participants indicated they were rarely addressed. The human resource management literature includes these seven components, with contingent reward, reduced status distinctions and measurement of management practices, as the essential organisational underpinnings of high performance work systems. The results of this study propose that clinical leadership is an organisational property, suggesting that capability frameworks and educational programs for clinical leadership need a broader organisation focus. The paper

  15. Optimization of Composite Material System and Lay-up to Achieve Minimum Weight Pressure Vessel

    Science.gov (United States)

    Mian, Haris Hameed; Wang, Gang; Dar, Uzair Ahmed; Zhang, Weihong

    2013-10-01

    The use of composite pressure vessels particularly in the aerospace industry is escalating rapidly because of their superiority in directional strength and colossal weight advantage. The present work elucidates the procedure to optimize the lay-up for composite pressure vessel using finite element analysis and calculate the relative weight saving compared with the reference metallic pressure vessel. The determination of proper fiber orientation and laminate thickness is very important to decrease manufacturing difficulties and increase structural efficiency. In the present work different lay-up sequences for laminates including, cross-ply [ 0 m /90 n ] s , angle-ply [ ±θ] ns , [ 90/±θ] ns and [ 0/±θ] ns , are analyzed. The lay-up sequence, orientation and laminate thickness (number of layers) are optimized for three candidate composite materials S-glass/epoxy, Kevlar/epoxy and Carbon/epoxy. Finite element analysis of composite pressure vessel is performed by using commercial finite element code ANSYS and utilizing the capabilities of ANSYS Parametric Design Language and Design Optimization module to automate the process of optimization. For verification, a code is developed in MATLAB based on classical lamination theory; incorporating Tsai-Wu failure criterion for first-ply failure (FPF). The results of the MATLAB code shows its effectiveness in theoretical prediction of first-ply failure strengths of laminated composite pressure vessels and close agreement with the FEA results. The optimization results shows that for all the composite material systems considered, the angle-ply [ ±θ] ns is the optimum lay-up. For given fixed ply thickness the total thickness of laminate is obtained resulting in factor of safety slightly higher than two. Both Carbon/epoxy and Kevlar/Epoxy resulted in approximately same laminate thickness and considerable percentage of weight saving, but S-glass/epoxy resulted in weight increment.

  16. Advanced Manufacturing for Thermal and Environmental Control Systems: Achieving National Energy Goals

    Energy Technology Data Exchange (ETDEWEB)

    Bogucz, Edward A. [Syracuse Univ., NY (United States)

    2017-02-20

    evaluated by a national panel of experts. Three projects were selected for awards and were completed successfully during the second budget period: Seed Project 3 focused on enabling self-powered furnaces to permit residents to shelter in place during power outages; Seed Project 4 addressed development of a novel method of controlling air conditioning systems that could enable flexible load matching in market segments not possible with existing technologies; and Seed Project 5 focused on the creation of smarter occupancy sensors to enable effective highly localized demand based ventilation.

  17. Achievement report for fiscal 1998. Home rehabilitation system for aphasia patients; 1998 nendo seika hokokusho. Shitsugosho zaitaku rehabilitation shien system

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-05-01

    Development has been made on the element technologies for a home rehabilitation system for aphasia patients. First, studies were performed on an authoring procedure for aphasia patient training, and partial trial production and development were carried out on an authoring system for the training program formula. Then, studies were executed on a training simulation and analysis filter, and partial trial production and development were implemented on a home rehabilitation supporting and self-teaching system. Next, an input and output mechanism for voice signal processing was studied, and aphasia patient and caregiver human interface was partially fabricated on a trial basis. In addition, a remote rehabilitation communicating method was researched, and partial trial production was carried out on a remote rehabilitation evaluation and diagnosis support means. Finally, communication assisting means were researched, and a communication assisting system was partially produced on a trial basis. Good evaluation results were given on a demonstration system. Although partial indications were given on minute parts, practical agreement was obtained as a whole. Great expectation was given particularly on the remote rehabilitation system and the authoring system. (NEDO)

  18. Achievement report on developing inverse manufacturing system in fiscal 1998; 1998 nendo inverse manufacturing system no kaihatsu seika hokokusho

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-03-01

    Research and development has been performed on a circulating type production system, or an inverse manufacturing system, to minimize the environmental load in the entire life cycle of industrial products from design to manufacturing, maintenance, recovery, and re-utilization. In developing the recycling information system, discussion and extraction were executed on the data to be exchanged between manufacturers and users in the inverse society. A new individual parts history control system was developed. In developing the recycling processing system, a prototype system was evaluated by using hypothetical data, wherein the possibility of improving the recycling processing efficiency and reducing the cost was verified. In addition, trial design was made on a recycling processing plant in consideration of the cost effect to get the future plant image. In fabricating the inverse manufacturing products, a prototype concept model was made for information terminal devices. Development was performed on such elementary technologies as the easy-to-disintegrate structure technology, self-integration connecting structure and environmental hysteresis detection system. (NEDO)

  19. The Effect of the Instructional Media Based on Lecture Video and Slide Synchronization System on Statistics Learning Achievement

    Directory of Open Access Journals (Sweden)

    Partha Sindu I Gede

    2018-01-01

    Full Text Available The purpose of this study was to determine the effect of the use of the instructional media based on lecture video and slide synchronization system on Statistics learning achievement of the students of PTI department . The benefit of this research is to help lecturers in the instructional process i to improve student's learning achievements that lead to better students’ learning outcomes. Students can use instructional media which is created from the lecture video and slide synchronization system to support more interactive self-learning activities. Students can conduct learning activities more efficiently and conductively because synchronized lecture video and slide can assist students in the learning process. The population of this research was all students of semester VI (six majoring in Informatics Engineering Education. The sample of the research was the students of class VI B and VI D of the academic year 2016/2017. The type of research used in this study was quasi-experiment. The research design used was post test only with non equivalent control group design. The result of this research concluded that there was a significant influence in the application of learning media based on lectures video and slide synchronization system on statistics learning result on PTI department.

  20. Agroenergy production from biomass in integrated agroforestry systems: an alternative to achieve food security and environmental protection

    International Nuclear Information System (INIS)

    Suárez, J.; Martín, G. J.

    2010-01-01

    The objective of this paper is to offer considerations about agroenergy production from biomass in integrated agroforestry systems. At present, worldwide, marked by a group of hazards that threaten human existence, there is a challenge mainly in the rural context: how can the coexistence of agroenergy, food security and environmental protection be achieved?, in the presence of climate changes, environmental degradation, food crises and the growing biofuels vs food contradiction, generated by a senseless policy for obtaining first-generation agrofuels from large extensions of food monocrops, which is morally rejectable. Biofuels are also considered an ecological alternative to fossil fuels, because of their reduction capacity in the emission of greenhouse gasses and because they promote the development of rural communities in southern countries; this is enhanced in integrated agroforestry systems, in which biofuels, of first as well as second generation, can be produced, especially with the application of the concept of biorefinery which allows converting biomass into many products, which total added value can be higher than the one generated by fossil fuels. International projects, which promote integrated and sustainable food and energy production in the context of agroforestry integrated systems, at local scale, contribute to this purpose. The authors consider that the execution of projects and experiences about agroenergy has the main objective of achieving energetic sustainability and food security at local scale, in rural areas, taking into account environmental protection. (author)

  1. E16 Sandvika-Wøyen - Analysis of tunnel excavation, achieved contour quality and influence of applied initiation system.

    OpenAIRE

    Sklodowska, Anna Maria

    2016-01-01

    The drill and blast excavation method is the most commonly used method for tunnel construction in Norway. In D&B the results from blasting can be evaluated through several factors, such as pull percentage, vibration level and contour quality. The main goal of the thesis was to analyze excavation with a special focus on the quality of the achieved contour and the influence of the applied initiation system. The analysis was performed based on results from the Bjørnegård tunnel, which wa...

  2. The no-cost radwaste resource: Utilizing the system engineer to help achieve optimum radwaste system performance

    International Nuclear Information System (INIS)

    Green, R.; Michalski, M.

    1995-01-01

    All of us in the nuclear power business today know and often use words like - de-regulation, downsize, manpower reduction, cost savings, budget cuts, cost per kilowatt and probably 25 other terms, all relating to you doing a better job with less money and fewer resources. Maybe I have a suggestion that will help you find a resource that can help you - a no-cost resource that you may already have and may not be using. I don't know what you believe, but I believe that a nuclear power station can only be as good as the people who work there, and I believe that system performance and reliability can be improved on virtually any system by merely directing focus and attention to that system. In other words, systems are like children, if you neglect them, they go bad... And they go bad when you're not expecting it. This paper looks at what a system engineer can do for you toward a goal of optimum Radwaste system performance and reviews some of the tools we are using at Grand Gulf to reach our goals

  3. The System of Indicators for Monitoring the Achievement of the Goals of Sustainable Development in the Agrarian Sector

    Directory of Open Access Journals (Sweden)

    Chala Tеtyana G.

    2017-06-01

    Full Text Available The article describes the results of statistical evaluation of the system of indicators for monitoring the achievement of the goals of sustainable development (GSD in the agrarian sector. It has been determined that, in order to achieve sustainable development, the following three pillars need to be reconciled: economic growth, social integration, and environmental protection. The objectives and indicators of the GSD 2 «Overcoming hunger, achieving food security, improving nutrition, and facilitating sustainable development of agriculture» were considered in detail. It has been determined that the indicator, which illustrates vividly the status and perspective of development of the agrarian sector, is the indicator 2.a.1 «Index of orientation towards agriculture, defined by the public expenditure structure». Methods for calculation of the Agriculture Orientation Index (AOI were considered. The dynamics of the AOI for Ukraine and world-wide for 2004-2013 were analyzed. The values of the AOI index for Ukraine, the neighboring countries, and the EU Member States in 2013 have been provided. It has been determined that Ukraine has a low AOI among the EU countries and among the neighboring countries, which indicates a poor orientation towards agriculture.

  4. The Barriers to Achieve Financial Protection in Iranian Health System: A Qualitative Study in a Developing Country.

    Science.gov (United States)

    Naghdi, Seyran; Moradi, Tayebeh; Tavangar, Fateh; Bahrami, Giti; Shahboulaghi, Mohammadi; Ghiasvand, Hesam

    2017-09-01

    The move to universal health coverage and consequently health promotion is influenced by political, socio-economic and other contextual factors in a country. Iran, as a developing country with an upper-middle national income, has developed policies to achieve universal health coverage through financial protection. This study aims to investigate barriers to develop financial protection as a requirement to achieve universal health coverage. This qualitative study was conducted using 20 in-depth interviews with experts in social welfare, health insurance and financing. The framework analysis method was used to analyze the data. The results have been categorized in three major themes that were extracted from ten sub-themes. The major themes included the political, social and economic context of the country, the context and structure of healthcare system and dimensions of UHC. Achieving financial protection as a long-term objective should be considered as a priority among Iranian policy makers that requires an inter-sectoral collaboration with a defined in-charge body. Health policy makers in Iran should develop a more comprehensive benefits package for diseases and health conditions with catastrophic consequences. They also should develop a plan to cover the poor people.

  5. Thermal degradation features of peppermint oil in a binary system with Β- cyclodextrin

    Directory of Open Access Journals (Sweden)

    I. A. Omelchenko

    2016-04-01

    Full Text Available Aim. One of the most promising ways of changing physical and chemical properties of the active pharmaceutical ingredient is an encapsulation on a molecular level with the use of cyclodextrins. This makes it possible to create products with the desired activity and controlled distribution in the body. Methods and results. We have studied the thermal decomposition of peppermint oil in binary systems with β-cyclodextrin. It has been found that the thermal degradation of mechanical mixture and inclusion complex of the «host-guest» with the composition of 1:1 passes through different mechanisms. Conclusions. It is shown that the given data of thermal stability are useful for the identification of an inclusion complex «β-CD – peppermint oil» and assessing its complexation, and for the development of technology of medicinal forms of supramolecular complex of β-cyclodextrin and peppermint oil

  6. Chiral Binaphthylbis(4,4'-Bipyridin-1-Ium)/Cucurbit[8]Uril Supramolecular System and Its Induced Circularly Polarized Luminescence.

    Science.gov (United States)

    Chen, Xu-Man; Chen, Yong; Liang, Lu; Liu, Qiu-Jun; Liu, Yu

    2018-05-01

    Circularly polarized luminescence (CPL) induced by host-guest complexation remains a challenge in supramolecular chemistry. Herein, a couple of CPL-silent enantiomeric guest binaphthylbis(4,4'-bipyridinium) salts can emit obvious CPL in the presence of cucurbit[8]uril in aqueous media, due to the restriction of molecular rotation limitation effect. Such CPL can be reversibly adjusted by the addition of acid and base. Furthermore, the resultant supramolecular systems can interact with DNA, accompanied by the morphological conversion from branched supramolecular nanowires to exfoliated nanowires, which can enable to the exploration of such supramolecular systems as DNA markers by CPL signals. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  7. Building America Residential System Research Results: Achieving 30% Whole House Energy Savings Level in Marine Climates; January 2006 - December 2006

    Energy Technology Data Exchange (ETDEWEB)

    Building America Industrialized Housing Partnership (BAIHP); Building Industry Research Alliance (BIRA); Building Science Consortium (BSC); Consortium for Advanced Residential Buildings (CARB); Davis Energy Group (DEG); IBACOS; National Association of Home Builders Research Center (NAHBRC); National Renewable Energy Laboratory (NREL)

    2006-12-01

    The Building America program conducts the system research required to reduce risks associated with the design and construction of homes that use an average of 30% to 90% less total energy for all residential energy uses than the Building America Research Benchmark, including research on homes that will use zero net energy on annual basis. To measure the program's progress, annual research milestones have been established for five major climate regions in the United States. The system research activities required to reach each milestone take from 3 to 5 years to complete and include research in individual test houses, studies in pre-production prototypes, and research studies with lead builders that provide early examples that the specified energy savings level can be successfully achieved on a production basis. This report summarizes research results for the 30% energy savings level and demonstrates that lead builders can successfully provide 30% homes in the Marine Climate Region on a cost neutral basis.

  8. The Effect of Contextual Teaching and Learning Combined with Peer Tutoring towards Learning Achievement on Human Digestive System Concept

    Directory of Open Access Journals (Sweden)

    Farhah Abadiyah

    2017-11-01

    Full Text Available This research aims to know the influence of contextual teaching and learning (CTL combined with peer tutoring toward learning achievement on human digestive system concept. This research was conducted at one of State Senior High School in South Tangerang in the academic year of 2016/2017. The research method was quasi experiment with nonequivalent pretest-postest control group design. The sample was taken by simple random sampling. The total of the sampels were 86 students which consisted of 44 students as a controlled group and 42 students as an experimental group. The research instrument was objective test which consisted of 25 multiple choice items of each pretest and posttest. The research also used observation sheets for teacher and students activity. The result of data analysis using t-test on the two groups show that the value of tcount was 2.40 and ttable was 1.99 on significant level α = 0,05, so that tcount > ttable.. This result indicated that there was influence of contextual teaching and learning (CTL combined with peer tutoring toward learning achievement on human digestive system concept.

  9. Analysis of development achievement of overseas resources and study of plans of system improvement (bituminous coal, general mineral resources)

    Energy Technology Data Exchange (ETDEWEB)

    Hwang, J N [Korea Energy Economics Institute, Euiwang (Korea, Republic of)

    1998-05-01

    Development policy of overseas resources of Korea should be carried out as a part of long-term resources security policy that can prepare for the stable supply and demand of needed resources under the proper economic size and industrial structure. This study tried to search for the ways to promote overseas development of bituminous coal and, general mineral resources, and support them more effectively per field. For this, development achievements so far, domestic and foreign pending issues, and operation status of the support system are studied, analyzed, and the improvement plans are drafted per field. Financial support for overseas resources development should be more expanded than the present in the future. For this, the current collateral system centered on real right should be improved and financial support centered on the credit of enterprise should be reinforced. Besides, in the related tax support system, related tax laws and systems should be improved in order to alleviate the tax burden of business operators so that they can carry out the overseas resources development business with more advantageous conditions through the additive introduction of current deduction system of indirect payment tax. Since payback period of overseas resources development business tends to become long-term, it should be continuously carried out based on future-oriented development investment plan and will of more than twenty (20) years rather than on temporary development support plan based on short-term market trend. 25 refs., 73 tabs.

  10. Achieving transparency in the total system performance assessment of a potential high level radioactive waste repository at Yucca Mountain, Nevada

    International Nuclear Information System (INIS)

    Bailey, J.; Rickertsen, L.; Cotton, T.

    1999-01-01

    This paper has presented an approach to quantitative assessment of the degree of postclosure defense-in-depth provided by the reference system of the VA (Viability Assessment). This approach identifies principal barriers, assesses barriers for common uncertainty and failure mode, conducts barrier neutralization analyses, and evaluates overall defense-in-depth. The neutralization approach of step 3 is particularly useful in untangling the contributions of various barriers to the results calculated by performance assessments. In fact, it provides the only way of assessing the contribution of barriers that are fully redundant with one another. The approach has been applied to the VA reference system. It shows how the natural transport barriers contribute to performance of the system. Since their individual contributions are redundant, uncertainties in those individual contributions are reduced in importance. The analyses also suggest uncertainties common to both of these barriers are important to the safety assessment. Thus, the approach appears to be capable of determining the contribution of the principal barriers to system performance. The ability to use performance assessment to show not only how the repository system is expected to perform, but also how it achieves that performance, should contribute substantially towards providing needed transparency to the safety case for a geologic repository. It is also a valuable tool during the development of the repository design and associated safety case, by identifying areas in which performance would be enhanced by increased redundancy

  11. Do attitudes toward societal structure predict beliefs about free will and achievement? Evidence from the Indian caste system.

    Science.gov (United States)

    Srinivasan, Mahesh; Dunham, Yarrow; Hicks, Catherine M; Barner, David

    2016-01-01

    Intuitive theories about the malleability of intellectual ability affect our motivation and achievement in life. But how are such theories shaped by the culture in which an individual is raised? We addressed this question by exploring how Indian children's and adults' attitudes toward the Hindu caste system--and its deterministic worldview--are related to differences in their intuitive theories. Strikingly, we found that, beginning at least in middle school and continuing into adulthood, individuals who placed more importance on caste were more likely to adopt deterministic intuitive theories. We also found a developmental change in the scope of this relationship, such that in children, caste attitudes were linked only to abstract beliefs about personal freedom, but that by adulthood, caste attitudes were also linked to beliefs about the potential achievement of members of different castes, personal intellectual ability, and personality attributes. These results are the first to directly relate the societal structure in which a person is raised to the specific intuitive theories they adopt. © 2015 John Wiley & Sons Ltd.

  12. Report on achievements of research and development of an automatic sewing system in fiscal 1988. Three-dimensional flexible sub-system; 1988 nendo jido hosei system no kenkyu kaihatsu seika hokokusho. Sanjigen flexible sub system

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1989-03-01

    The Automatic Sewing System Technology Research Association was commissioned from the Agency of Industrial Science and Technology on research of a production system by apparel types and systematization of an experiment plant. As the research on systematizing the experiment plant, the association is tackling with the researches on a high-speed laser cutting sub-system, a flexible sewing sub-system, a hi-tech assembling sub-system, and a three-dimensional flexible pressing sub-system. This paper reports the achievement of the research and development on the three-dimensional flexible pressing sub-system. It was intended to move forward development of technologies to put on and take off apparels and transport products, to achieve interlocking with other component technologies, and to structure an efficient pressing and processing system for finish. An experiment plant was built for ladies' blazer coats set as objects of model wears. The plant operation experiments and comprehensive evaluation are scheduled to be performed in fiscal 1990. Therefore, basic design research was carried out on an automatic put-on/take-off device and an auto-hanger system with an objective of application of the experimental plant. Studies on accuracy improvement was executed in the research of setting shapes of flexible dummies. In the research of pressing conditions, application of the 'estimation type information retrieval and control system' was studied. As a result, achievements were obtained as nearly as has been initially intended. (NEDO)

  13. Implementation of a quality management system according to 9001 standard in a hospital in the home unit: changes and achievements.

    Science.gov (United States)

    Rodríguez-Cerrillo, Matilde; Fernández-Diaz, Eddita; Iñurrieta-Romero, Amaia; Poza-Montoro, Ana

    2012-01-01

    The purpose of this paper is to describe changes and results obtained after implementation of a quality management system (QMS) according to ISO standards in a Hospital in the Home (HIH) Unit. The paper describes changes made and outcomes achieved. This took part in the HiH Unit, Clinico Hospital, Madrid, Spain, and looked at admissions, mean stay, patient satisfaction, adverse events, returns to hospital, no admitted referrals, complaints, compliance to protocols, equipment failures and resolution of urgent consultations. In June 2008, HiH Unit, Clinico Hospital obtained ISO certification. The main results achieved are as follows. There was an increase in patients' satisfaction--in June 2008, assessment of the quality of care provided by staff was scored at 4.7 (on a scale of 1 to 5); in 2010 it has been scored at 4.96. Patient satisfaction rate has increased from 92 percent to 98.8 percent. No complaints from patients were received. Unscheduled returns to hospital have decreased from 7 percent to 3 percent. There were no medical equipment failures. External suppliers' performance has improved. Material and medication needed by staff was available when necessary. The number of admissions has increased. Compliance to protocols has reached 97 percent. Inappropriate referrals have decreased by 8 percent. Six medications-related incidents were detected; in two cases the incident was not due to an error. In the other four cases error could have been detected before reaching the patient. Implementations of an ISO quality management system allow improved quality of care and patient satisfaction in a HIH Unit.

  14. The use of Jatropha curcas to achieve a self sufficient water distribution system: A case study in rural Senegal

    Science.gov (United States)

    Archer, Alexandra

    The use of Jatropha curcas as a source of oil for fueling water pumps holds promise for rural communities struggling to achieve water security in arid climates. The potential for use in developing communities as an affordable, sustainable fuel source has been highly recommended for many reasons: it is easily propagated, drought resistant, grows rapidly, and has high-oil-content seeds, as well as medicinal and economic potential. This study uses a rural community in Senegal, West Africa, and calculates at what level of Jatropha curcas production the village is able to be self-sufficient in fueling their water system to meet drinking, sanitation and irrigation requirements. The current water distribution system was modelled to represent irrigation requirements for nine different Jatropha curcas cultivation and processing schemes. It was found that a combination of using recycled greywater for irrigation and a mechanical press to maximize oil recovered from the seeds of mature Jatropha curcas trees, would be able to operate the water system with no diesel required.

  15. Achievement of high availability in long-term operation and upgrading plan of the LHD superconducting system

    International Nuclear Information System (INIS)

    Imagawa, S.; Yanagi, N.; Hamaguchi, S.

    2006-10-01

    The Large Helical Device (LHD) that has been demonstrating high performance of heliotron plasma is the world's largest superconducting system. Availability higher than 98% has been achieved in a long-term continuous operation both in the cryogenic system and in the power supply system. It will be owing not only to the robustness of the systems but also to efforts of maintenance and operation. One big problem is shortage of cryogenic stability of a pair of pool-cooled helical coils. Composite conductors had been developed to attain the sufficient stability at high current density. However, it was revealed that a normal-zone could propagate below the cold-end recovery current by additional heat generation due to the slow current diffusion into a thick pure aluminium stabilizer. Besides, a novel detection system with pick-up coils along the helical coils revealed that normal-zones were initiated near the bottom of the coil where the field is not the highest. Therefore, the cooling condition around the innermost layers, the high field area, will be deteriorated at the bottom of the coil by bubbles gathered by buoyancy. In order to raise the operating currents, methods for improving the cryogenic stability have been examined, and stability tests have been carried out with a model coil and small coil samples. The coil temperature is planned to be lowered from 4.4 K to 3.5 K, and the operating current is expected to be increased from 11.0 kA to 12.0 kA that corresponds to 3.0 T at the major radius of 3.6 m. (author)

  16. Colloidal chirality in wormlike micellar systems exclusively originated from achiral species: Role of secondary assembly and stimulus responsivity.

    Science.gov (United States)

    Zhao, Wenrong; Hao, Jingcheng

    2016-09-15

    Colloidal chirality in wormlike micellar systems exclusively originated from achiral species and discussion of the role of secondary assembly of fiber-like aggregates in chirality generation were presented in this paper. Herein, formation of colloidal wormlike micelles for the first time incorporated chirality and redox-responsiveness into one design via noncovalent interaction. A dual-stimuli-responsive gel of wormlike micelles which were designed by employing a dual-responsive cationic surfactant (FTMA) and a strong gelator (AzoNa4) and regulated by redox reaction and host-guest inclusion is presented. Both the redox and host-guest interaction play an important role in regulating the viscosity and supramolecular chirality of gels of the wormlike micelles. The supramolecular chirality and viscosity of the wormlike micelle gels were switched reversibly by exerting chemical redox onto the ferrocenyl groups. For the amphiphile FTMA containing redox-active ferrocenyl group, reversible control of the oxidation state of ferrocenyl groups leads to the charge and hydrophobicity changes of FTMA, therefore change its self-assembly behavior. Of equal interest, β-CD successfully detached the wormlike micelles via the recognition-inclusion behavior with FTMA and invalidate the H-bond and hydrophobic interaction between FTMA and AzoH4. This designed system provides a new strategy to tune the supramolecular chirality of colloidal aggregates and explore the specific packing mode detail within the micelles or the secondary assembly of the inter-micelles. We anticipate this dual-responsive H-bond-directed chiral gel switch could propose a new strategy when researchers designing new, multi-responsive functional gel materials. Copyright © 2016 Elsevier Inc. All rights reserved.

  17. The Impact of Resources on Education: A Position Paper on How Theories of Social Capital Provide Insight on the Achievement Gap in the United States Education System

    Science.gov (United States)

    Zeisler, Kayla

    2012-01-01

    Research has shown that there is a gap in educational achievement between socioeconomic and racial groups in the public education system in the United States. This paper identifies the link between resources and academic achievement. Through examining educational resources, from in-school factors, such as facilities and teacher quality, to…

  18. The introduction of the personnel dosimetry information system in Greece designed as a relational database and the improvements achieved

    International Nuclear Information System (INIS)

    Drikos, G.; Psaromiligos, J.; Geotgiou, G.; Kamenopoulou, V.K.

    1997-01-01

    Dose record keeping is the making and keeping of personnel dose records for radiation workers. It is an essential part of the process of monitoring the exposure of individuals to radiation and shares in the same objectives. The dose record keeping is becoming more and more critical because of the importance of statistical analysis and epidemiological studies in radiation protection, and of the increasing cooperation and exchange of personnel between countries.The GAEC's personnel dosimetry laboratory assures the personnel dosimetry all over the country and keeps the official central dose record.The personnel dosimetry information system had been established in an electronic form on 1989 in Cobol language. Since then appeared various arguments that imposed the change of the data base used. Some of them are: 1. There was no distinction between establishments and their laboratories. 2. The workers did not have a unique code number. consequently, the total dose of a person working in more than one place could not't be estimated. The workers were directly related to their workplace, so if somebody changed his working place he was treated as a new entry, resulting an overestimation of the number of monitored workers introducing an source of errors in the collective and average dose calculations. 3. With the increasing applications of the ionising radiations many types of dosemeters became indispensable e.g. for beta and gamma, for neutrons and for the extremities. Also, the new category of outside workers appeared requesting a special treatment. All these distinctions were not achievable with the previous system. 4. Last years appeared an increasing, interesting in statistical analysis of the personal doses. A program written in Cobol does not't offer many possibilities and has no flexibility for such analysis. The new information system has been rebuilt under the design of a relational database with more possibilities and more flexibility. (authors)

  19. Development of a low-cost biogas filtration system to achieve higher-power efficient AC generator

    Science.gov (United States)

    Mojica, Edison E.; Ardaniel, Ar-Ar S.; Leguid, Jeanlou G.; Loyola, Andrea T.

    2018-02-01

    The paper focuses on the development of a low-cost biogas filtration system for alternating current generator to achieve higher efficiency in terms of power production. A raw biogas energy comprises of 57% combustible element and 43% non-combustible elements containing carbon dioxide (36%), water vapor (5%), hydrogen sulfide (0.5%), nitrogen (1%), oxygen (0 - 2%), and ammonia (0 - 1%). The filtration system composes of six stages: stage 1 is the water scrubber filter intended to remove the carbon dioxide and traces of hydrogen sulfide; stage 2 is the silica gel filter intended to reduce the water vapor; stage 3 is the iron sponge filter intended to remove the remaining hydrogen sulfide; stage 4 is the sodium hydroxide solution filter intended to remove the elemental sulfur formed during the interaction of the hydrogen sulfide and the iron sponge and for further removal of carbon dioxide; stage 5 is the silica gel filter intended to further eliminate the water vapor gained in stage 4; and, stage 6 is the activated carbon filter intended to remove the carbon dioxide. The filtration system was able to lower the non-combustible elements by 72% and thus, increasing the combustible element by 54.38%. The unfiltered biogas is capable of generating 16.3 kW while the filtered biogas is capable of generating 18.6 kW. The increased in methane concentration resulted to 14.11% increase in the power output. The outcome resulted to better engine performance in the generation of electricity.

  20. Biogeochemical-Argo: achievements, challenges for the future and potential synergies with other components of ocean observation systems

    Science.gov (United States)

    Claustre, Hervé; Johnson, Ken

    2017-04-01

    The recently launched Biogeochemical-Argo (BGC-Argo) program aims at developing a global network of biogeochemical sensors on Argo profiling floats for acquiring long-term high-quality time-series of oceanic properties. BGC-Argo is in particular poised to address a number of challenges in ocean science (e.g. hypoxia, carbon uptake, ocean acidification, biological-carbon pump and phytoplankton communities), topics that are difficult, if not impossible, to address with our present observing assets. Presently six variables are considered as core BGC-Argo variables (O2, NO3, pH, Chla, suspended particles and downwelling irradiance). Historically, BGC-Argo has been initiated through small-scale "showcase" projects progressively scaling up into regional case studies essentially addressing key biological pump-related questions in specific regions (e.g. sub-tropical gyres, North Atlantic, Southern Ocean). Now BGC-Argo is transitioning towards a global and sustained observation system thanks to progressive international coordination of national contributions and to increasingly mature and efficient data management and distribution systems. In this presentation, we will highlight a variety of results derived from BGC-Argo observations and encompassing a wide range of topics related to ocean biogeochemistry. Challenges for the future and long-term sustainability of the system will be addressed in particular with respect to maintaining a high-quality and interoperable dataset over long-term. Part of this can be achieved through a tight interaction with programs (e.g. GOSHIP) and their historical databases, which should constitute a corner stone to assess data quality. Example on the interplay between BGC-Argo and GlodapV2 databases will be particularly exemplified in this context. Furthermore, we will illustrate the potential synergies between synoptically measured surface satellite-quantities and their vertically resolved (BGC-Argo) counterparts into the development of 3D

  1. Microcalorimetric and spectrographic studies on host-guest interactions of {alpha}-, {beta}-, {gamma}- and M{beta}-cyclodextrin with resveratrol

    Energy Technology Data Exchange (ETDEWEB)

    Li, Hui; Xu, Xiangyu; Liu, Min [College of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng 252059, Shandong Province (China); Sun, Dezhi, E-mail: sundezhisdz@163.com [College of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng 252059, Shandong Province (China); Li, Linwei, E-mail: lilinwei@lcu.edu.cn [College of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng 252059, Shandong Province (China)

    2010-10-20

    Thermal effects of inclusion processes of {alpha}-, {beta}-, {gamma}- and M{beta}-cyclodextrin with resveratrol (RES) in aqueous solutions were determined by isothermal titration calorimetry (ITC) with nanowatt sensitivity at the temperature of 298.15 K. Standard enthalpy changes, stoichiometry and equilibrium constants of the inclusion complexes were derived from the direct calorimetric data utilizing nonlinear simulation. The thermodynamic parameters were discussed in the light of weak interactions between the host and the guest molecules combining with UV spectral message. The results indicate that all of the complexes formed in the aqueous solutions are in 1:1 stoichiometry. The binding processes of {alpha}-, {beta}- and M{beta}-cyclodextrin with the guest are mainly driven by enthalpy, while that of {gamma}-cyclodextrin with the drug is driven by both enthalpy and entropy.

  2. Structural elucidation of dendritic host-guest complexes by X-ray crystallography and molecular dynamics simulations

    NARCIS (Netherlands)

    Chang, T.; Pieterse, K.; Broeren, M.A.C.; Kooijman, H.; Spek, A.L.; Hilbers, P.A.J.; Meijer, E.W.

    2007-01-01

    The multiple monovalent binding of adamantyl-urea poly(propyleneimine) dendrimers with carboxylic acid-urea guests was investigated using molecular dynamics simulations and X-ray crystallography to better understand the structure and behavior of the dynamic multivalent complex in solution. The

  3. Formation of hybrid gold nanoparticle network aggregates by specific host-guest interactions in a turbulent flow reactor

    NARCIS (Netherlands)

    Weinhart-Mejia, R.; Huskens, Jurriaan

    2014-01-01

    A multi-inlet vortex mixer (MIVM) was used to investigate the formation of hybrid gold nanoparticle network aggregates under highly turbulent flow conditions. To form aggregates, gold nanoparticles were functionalized with β-cyclodextrin (CD) and mixed with adamantyl (Ad)-terminated

  4. Smart SERS Hot Spots: Single Molecules Can Be Positioned in a Plasmonic Nanojunction Using Host-Guest Chemistry.

    Science.gov (United States)

    Kim, Nam Hoon; Hwang, Wooseup; Baek, Kangkyun; Rohman, Md Rumum; Kim, Jeehong; Kim, Hyun Woo; Mun, Jungho; Lee, So Young; Yun, Gyeongwon; Murray, James; Ha, Ji Won; Rho, Junsuk; Moskovits, Martin; Kim, Kimoon

    2018-04-04

    Single-molecule surface-enhanced Raman spectroscopy (SERS) offers new opportunities for exploring the complex chemical and biological processes that cannot be easily probed using ensemble techniques. However, the ability to place the single molecule of interest reliably within a hot spot, to enable its analysis at the single-molecule level, remains challenging. Here we describe a novel strategy for locating and securing a single target analyte in a SERS hot spot at a plasmonic nanojunction. The "smart" hot spot was generated by employing a thiol-functionalized cucurbit[6]uril (CB[6]) as a molecular spacer linking a silver nanoparticle to a metal substrate. This approach also permits one to study molecules chemically reluctant to enter the hot spot, by conjugating them to a moiety, such as spermine, that has a high affinity for CB[6]. The hot spot can accommodate at most a few, and often only a single, analyte molecule. Bianalyte experiments revealed that one can reproducibly treat the SERS substrate such that 96% of the hot spots contain a single analyte molecule. Furthermore, by utilizing a series of molecules each consisting of spermine bound to perylene bisimide, a bright SERS molecule, with polymethylene linkers of varying lengths, the SERS intensity as a function of distance from the center of the hot spot could be measured. The SERS enhancement was found to decrease as 1 over the square of the distance from the center of the hot spot, and the single-molecule SERS cross sections were found to increase with AgNP diameter.

  5. Multicolor Fluorescence Writing Based on Host-Guest Interactions and Force-Induced Fluorescence-Color Memory.

    Science.gov (United States)

    Matsunaga, Yuki; Yang, Jye-Shane

    2015-06-26

    A new strategy is reported for multicolor fluorescence writing on thin solid films with mechanical forces. This concept is illustrated by the use of a green-fluorescent pentiptycene derivative 1, which forms variably colored fluorescent exciplexes: a change from yellow to red was observed with anilines, and fluorescence quenching (a change to black) occurred in the presence of benzoquinone. Mechanical forces, such as grinding and shearing, induced a crystalline-to-amorphous phase transition in both the pristine and guest-adsorbed solids that led to a change in the fluorescence color (mechanofluorochromism) and a memory of the resulting color. Fluorescence drawings of five or more colors were created on glass or paper and could be readily erased by exposure to air and dichloromethane fumes. The structural and mechanistic aspects of the observations are also discussed. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  6. Insights into Unfolded Proteins from the Intrinsic phi/psi Propensities of the AAXAA Host-Guest Series

    Czech Academy of Sciences Publication Activity Database

    Towse, C. L.; Vymětal, Jiří; Vondrášek, Jiří; Daggett, V.

    2016-01-01

    Roč. 110, č. 2 (2016), s. 348-361 ISSN 0006-3495 R&D Projects: GA MŠk(CZ) LH11020 Institutional support: RVO:61388963 Keywords : polyproline-II helix * beta-sheet protein * random-coil behavior Subject RIV: BO - Biophysics Impact factor: 3.656, year: 2016

  7. High relative humidity in-package of fresh-cut fruits and vegetables: advantage or disadvantage considering microbiological problems and antimicrobial delivering systems?

    Science.gov (United States)

    Ayala-Zavala, J F; Del-Toro-Sánchez, L; Alvarez-Parrilla, E; González-Aguilar, G A

    2008-05-01

    This hypothesis article states that the high relative humidity (RH) of packaged fresh-cut fruits or vegetables that is associated with spoilage can be used as an advantageous way to deliver antimicrobial compounds using cyclodextrins (CDs) as carriers. CDs can function as antimicrobial delivery systems as they can release antioxidant and antimicrobial compounds (guest molecules) as the humidity levels increase in the headspace. Hydrophobic antimicrobial guests can be complexed with CDs due to the amphiphatic nature of the host. Then, at high RH values, due to the water-CDs interaction, host-guest interactions are weakened; consequently, the antimicrobial molecule is released and should protect the product against the microbial growth. Potential antimicrobial compounds capable of forming complexes with CDs are discussed, as well as possible applications to preserve fresh-cut produce and future research in this area.

  8. Report on achievements in fiscal 1999 on research and development of the Welfare Techno-system (Chofu); 1999 nendo Welfare Techno system kenkyu kaihatsu (Chofu) seika hokokusho

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-03-01

    Research and development has been performed on a variable type living environment system for elderly people and a system to assist medical welfare and life as a whole for elderly people at the Chofu Welfare Techno-house. This paper summarizes the achievements in fiscal 1999. In the research and development of the variable type living environment system for elderly people, fabrication was performed on the trial basis for a unit to facilitate transfer from a bed to a toilet and taking shower at the toilet seat position. The unit was installed at a hospital in the city of Chiba after discussions and improvements have been made. In the survey and research on welfare devices, for the purpose of serving for selecting welfare devices to be incorporated in variable type welfare houses, surveys were carried out on commercially available welfare devices capable of dealing with daily life actions. Welfare mini-town cases in overseas countries were investigated, taking up the Netherlands, Denmark and the U.S.A. as the object. In the research and development of the system to assist medical welfare and life as a whole for elderly people, design and preparation were carried out on the house terminal information systems and the town management systems. Operation of each information system was verified on a simulated network. (NEDO)

  9. Systemic Administration of Glibenclamide Fails to Achieve Therapeutic Levels in the Brain and Cerebrospinal Fluid of Rodents.

    Directory of Open Access Journals (Sweden)

    Carolina Lahmann

    Full Text Available Activating mutations in the Kir6.2 (KCNJ11 subunit of the ATP-sensitive potassium channel cause neonatal diabetes (ND. Patients with severe mutations also suffer from neurological complications. Glibenclamide blocks the open KATP channels and is the treatment of choice for ND. However, although glibenclamide successfully restores normoglycaemia, it has a far more limited effect on the neurological problems. To assess the extent to which glibenclamide crosses the blood-brain barrier (BBB in vivo, we quantified glibenclamide concentrations in plasma, cerebrospinal fluid (CSF, and brain tissue of rats, control mice, and mice expressing a human neonatal diabetes mutation (Kir6.2-V59M selectively in neurones (nV59M mice. As only small sample volumes can be obtained from rodents, we developed a highly sensitive method of analysis, using liquid chromatography tandem mass spectrometry acquisition with pseudo-selected reaction monitoring, achieving a quantification limit of 10ng/ml (20nM glibenclamide in a 30μl sample. Glibenclamide was not detectable in the CSF or brain of rats after implantation with subcutaneous glibenclamide pellets, despite high plasma concentrations. Further, one hour after a suprapharmacological glibenclamide dose was administered directly into the lateral ventricle of the brain, the plasma concentration was twice that of the CSF. This suggests the drug is rapidly exported from the CSF. Elacridar, an inhibitor of P-glycoprotein and breast cancer resistance protein (major multidrug resistance transporters at the BBB, did not affect glibenclamide levels in CSF and brain tissue. We also identified a reduced sensitivity to volatile anaesthetics in nV59M mice and showed this was not reversed by systemic delivery of glibenclamide. Our results therefore suggest that little glibenclamide reaches the central nervous system when given systemically, that glibenclamide is rapidly removed across the BBB when given intracranioventricularly

  10. Spatially Referenced Educational Achievement Data Exploration: A Web-Based Interactive System Integration of GIS, PHP, and MySQL Technologies

    Science.gov (United States)

    Mulvenon, Sean W.; Wang, Kening; Mckenzie, Sarah; Anderson, Travis

    2006-01-01

    Effective exploration of spatially referenced educational achievement data can help educational researchers and policy analysts speed up gaining valuable insight into datasets. This article illustrates a demo system developed in the National Office for Research on Measurement and Evaluation Systems (NORMES) for supporting Web-based interactive…

  11. Your Co-author Received 150 Citations: Pride, but Not Envy, Mediates the Effect of System-Generated Achievement Messages on Motivation.

    Science.gov (United States)

    Utz, Sonja; Muscanell, Nicole L

    2018-01-01

    ResearchGate, a social network site for academics, prominently displays the achievements of people one follows ("With 150 new reads, X was the most read author from their institute"). The goal of this paper was to examine the emotional and motivational effects of these system-generated messages, thereby extending prior research on envy-evoking status updates on Facebook to a professional context. We also extend the research on social comparisons and more broadly, on emotional responses elicited by social media. Specifically, social media research has largely focused on examining emotional reactions to content that is both generated by and is about others. In this research we directly examine updates generated by the system (ResearchGate) while also directly comparing reactions to updates about others' achievements with reactions to updates that are about the self-i.e., one's personal achievements which are also displayed on ResearchGate ("With 150 new reads, you were the most read author from your institute"). Particular attention was paid to the mediating role of envy and pride. The results of our quasi-experimental field study ( n = 419) showed that the achievements of others elicited envy, whereas personal achievements elicited pride. People exposed to their personal achievements (vs. the achievement of others) showed a higher motivation to work harder. This effect was mediated by pride, but not envy. The theoretical and practical implications of these findings are discussed.

  12. Your Co-author Received 150 Citations: Pride, but Not Envy, Mediates the Effect of System-Generated Achievement Messages on Motivation

    Science.gov (United States)

    Utz, Sonja; Muscanell, Nicole L.

    2018-01-01

    ResearchGate, a social network site for academics, prominently displays the achievements of people one follows (“With 150 new reads, X was the most read author from their institute”). The goal of this paper was to examine the emotional and motivational effects of these system-generated messages, thereby extending prior research on envy-evoking status updates on Facebook to a professional context. We also extend the research on social comparisons and more broadly, on emotional responses elicited by social media. Specifically, social media research has largely focused on examining emotional reactions to content that is both generated by and is about others. In this research we directly examine updates generated by the system (ResearchGate) while also directly comparing reactions to updates about others’ achievements with reactions to updates that are about the self—i.e., one’s personal achievements which are also displayed on ResearchGate (“With 150 new reads, you were the most read author from your institute”). Particular attention was paid to the mediating role of envy and pride. The results of our quasi-experimental field study (n = 419) showed that the achievements of others elicited envy, whereas personal achievements elicited pride. People exposed to their personal achievements (vs. the achievement of others) showed a higher motivation to work harder. This effect was mediated by pride, but not envy. The theoretical and practical implications of these findings are discussed. PMID:29780339

  13. Your Co-author Received 150 Citations: Pride, but Not Envy, Mediates the Effect of System-Generated Achievement Messages on Motivation

    Directory of Open Access Journals (Sweden)

    Sonja Utz

    2018-05-01

    Full Text Available ResearchGate, a social network site for academics, prominently displays the achievements of people one follows (“With 150 new reads, X was the most read author from their institute”. The goal of this paper was to examine the emotional and motivational effects of these system-generated messages, thereby extending prior research on envy-evoking status updates on Facebook to a professional context. We also extend the research on social comparisons and more broadly, on emotional responses elicited by social media. Specifically, social media research has largely focused on examining emotional reactions to content that is both generated by and is about others. In this research we directly examine updates generated by the system (ResearchGate while also directly comparing reactions to updates about others’ achievements with reactions to updates that are about the self—i.e., one’s personal achievements which are also displayed on ResearchGate (“With 150 new reads, you were the most read author from your institute”. Particular attention was paid to the mediating role of envy and pride. The results of our quasi-experimental field study (n = 419 showed that the achievements of others elicited envy, whereas personal achievements elicited pride. People exposed to their personal achievements (vs. the achievement of others showed a higher motivation to work harder. This effect was mediated by pride, but not envy. The theoretical and practical implications of these findings are discussed.

  14. Report on achievements of research and development of an automatic sewing system in fiscal 1986. Total system; 1986 nendo jido hosei system no kenkyu kaihatsu seika hokokusho. Total system

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1987-03-01

    The Automatic Sewing System Technology Research Association was commissioned from the Agency of Industrial Science and Technology on the 'development of an automatic sewing system'. The association has performed the research and development by dividing the subject into such component technologies as a total system and sewing preparation and processing technology, a sewing and assembling technology, a cloth handling technology, and a system management and control technology. This paper reports the achievement of the research and development on the total system. Such apparel side researches were performed on setting five kinds of trial wears to be said model wears, and on developing the component technologies by wear types. In addition, software research was carried out on automating five kinds of three-dimensional assembling and sewing works as the core works. With regard to codification required for the software, plans were established on apparel configuration codes, sewing specification codes, sewing device codes, and sewing attachment codes. Plans for indication symbols in the sewing works were also established. In the research based on FA and FMS, researches were executed on the facility plan in the system model and on an intermediate evaluation method, with information exchange being made with the apparel side researches. In researching the retrofit technologies, researches were performed to incorporate the principle of achieving the target. (NEDO)

  15. Report on achievements of research and development of an automatic sewing system in fiscal 1986. Total system; 1986 nendo jido hosei system no kenkyu kaihatsu seika hokokusho. Total system

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1987-03-01

    The Automatic Sewing System Technology Research Association was commissioned from the Agency of Industrial Science and Technology on the 'development of an automatic sewing system'. The association has performed the research and development by dividing the subject into such component technologies as a total system and sewing preparation and processing technology, a sewing and assembling technology, a cloth handling technology, and a system management and control technology. This paper reports the achievement of the research and development on the total system. Such apparel side researches were performed on setting five kinds of trial wears to be said model wears, and on developing the component technologies by wear types. In addition, software research was carried out on automating five kinds of three-dimensional assembling and sewing works as the core works. With regard to codification required for the software, plans were established on apparel configuration codes, sewing specification codes, sewing device codes, and sewing attachment codes. Plans for indication symbols in the sewing works were also established. In the research based on FA and FMS, researches were executed on the facility plan in the system model and on an intermediate evaluation method, with information exchange being made with the apparel side researches. In researching the retrofit technologies, researches were performed to incorporate the principle of achieving the target. (NEDO)

  16. Report on achievements of research and development of an automatic sewing system in fiscal 1988. High-tech assembling sub-system; 1998 nendo jido hosei system no kenkyu kaihatsu seika hokokusho. Haiteku assemble sub system

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1989-03-01

    The Automatic Sewing System Technology Research Association was commissioned from the Agency of Industrial Science and Technology on research of a production system by apparel types and systematization of an experiment plant. As the research on systematizing the experiment plant, the association is tackling with the researches on a high-speed laser cutting sub-system, a flexible sewing sub-system, a hi-tech assembling sub-system, and a three-dimensional flexible pressing sub-system. This paper reports the achievement of the research and development on the hi-tech assembling sub-system. This system was studied by grouping the system into a seam sewing technology and a three-dimensional sewing technology. The former technology deals with the processes of seam sewing of the side of the left body part in a model wear, sew-up margin division, straightening, and back center seam sewing. The latter technology deals with the sleeve fitting process. Although these processes are the subject of automated system, it is difficult to automate the back collar sewing, shoulder sewing and front collar sewing after the back center seam sewing process to just before the sleeve fitting process. Therefore, these processes are processed by retrofitting and three-dimensional sewing devices, and a control computer to transmit, receive and control the information required for the devices. The utilizing conditions of the sub-system constituting devices and the component technologies are tabulated in a table. (NEDO)

  17. Report on achievements of research and development of an automatic sewing system in fiscal 1988. Flexible sewing system; 1988 nendo jido hosei system no kenkyu kaihatsu seika hokokusho. Flexible sewing system

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1989-03-01

    The Automatic Sewing System Technology Research Association was commissioned from the Agency of Industrial Science and Technology on research of a production system by apparel types and systematization of an experiment plant. As the research on systematizing the experiment plant, the association is tackling with the researches on a high-speed cutting sub-system, a flexible sewing sub-system, a hi-tech assembling sub-system, and a three-dimensional flexible pressing sub-system. This paper reports the achievement of the research and development on the flexible sewing sub-system. For this sub-system, researches were made on the experiment plant and the systematization by dividing them into (1) a high-function pattern technology, (2) a stabilization pre-treatment technology, (3) a multi-functional sewing technology, and (4) a production control technology. For the technology (1), easy processibility patterns and production and processing information were studied. For the technology (2), a technology to evaluate characteristics of padding material properties, a temporary hardening technology, and a high-frequency induction heating device to bond the right side with the padding were studied. For the technology (3), stations for multi-functional sewing, automatic dart sewing, automatic piping, and automatic pocket attaching, and various carrier devices, inspection devices, and printed information recognition devices were studied. For the technology (4), a process designing expert system and an automatic machine management and control system were studied. (NEDO)

  18. Factors Influencing Junior High School Students’ English Language Achievement in Taiwan: A Bronfenbrenner’s Ecological System Approach

    Directory of Open Access Journals (Sweden)

    Hsin-Yi Kung

    2016-06-01

    Full Text Available This study aimed to construct a social profile of Taiwanese students’ English language achievement by employing Bronfenbrenner’s perspectives. Data were collected on a sample of 709 ninth graders in central Taiwan via survey questionnaires and were analyzed using structural equation modeling. The results indicated that, first, a Taiwanese Students' English Language Achievement model was constructed by parental involvement, teachers’ beliefs/attitudes, parent–teacher interaction, and mass media/the Internet. Second, mass media/the Internet significantly predicted parental involvement and teachers’ beliefs/attitudes; parental involvement and teachers’ beliefs/attitudes significantly predicted students’ English language achievement; the correlation between parental involvement and teachers’ beliefs/attitudes was significant. Third, the completely mediating effects of parental involvement and teachers’ beliefs/attitudes in predicting students’ English language achievement from mass media/the Internet were supported, and the effect of teachers’ beliefs/attitudes tended to be stronger than parental involvement. These findings were in line with Bronfenbrenner’s theory and demonstrate that the influence of the mass media/the Internet (exosystem in students’ English language achievement conveyed the degree of parental involvement (microsystem, teachers’ beliefs/attitudes (microsystem, and the interaction between parents and teachers (mesosystem, especially within the context of the socio-cultural atmosphere in Taiwan (macrosystem. Implications and suggestions were discussed and provided to enhance students’ English language learning.

  19. Stopping power accuracy and achievable spatial resolution of helium ion imaging using a prototype particle CT detector system

    Directory of Open Access Journals (Sweden)

    Volz Lennart

    2017-09-01

    Full Text Available A precise relative stopping power map of the patient is crucial for accurate particle therapy. Charged particle imaging determines the stopping power either tomographically – particle computed tomography (pCT – or by combining prior knowledge from particle radiography (pRad and x-ray CT. Generally, multiple Coulomb scattering limits the spatial resolution. Compared to protons, heavier particles scatter less due to their lower charge/mass ratio. A theoretical framework to predict the most likely trajectory of particles in matter was developed for light ions up to carbon and was found to be the most accurate for helium comparing for fixed initial velocity. To further investigate the potential of helium in particle imaging, helium computed tomography (HeCT and radiography (HeRad were studied at the Heidel-berg Ion-Beam Therapy Centre (HIT using a prototype pCT detector system registering individual particles, originally developed by the U.S. pCT collaboration. Several phantoms were investigated: modules of the Catphan QA phantom for analysis of spatial resolution and achievable stopping power accuracy, a paediatric head phantom (CIRS and a custom-made phantom comprised of animal meat enclosed in a 2 % agarose mixture representing human tissue. The pCT images were reconstructed applying the CARP iterative reconstruction algorithm. The MTF10% was investigated using a sharp edge gradient technique. HeRad provides a spatial resolution above that of protons (MTF1010%=6.07 lp/cm for HeRad versus MTF10%=3.35 lp/cm for proton radiography. For HeCT, the spatial resolution was limited by the number of projections acquired (90 projections for a full scan. The RSP accuracy for all inserts of the Catphan CTP404 module was found to be 2.5% or better and is subject to further optimisation. In conclusion, helium imaging appears to offer higher spatial resolution compared to proton imaging. In future studies, the advantage of helium imaging compared to other

  20. Achieving Lower Nitrogen Balance and Higher Nitrogen Recovery Efficiency Reduces Nitrous Oxide Emissions in North America's Maize Cropping Systems

    Directory of Open Access Journals (Sweden)

    Rex A. Omonode

    2017-06-01

    2O. However, N2O reduction benefits of optimum N rate-by-timing practices were achieved most consistently with management systems that reduced NNB through an increase of grain N removal or total plant N uptake relative to the total fertilizer N applied to maize. Future research assessing crop or N management effects on N2O should include N uptake parameter measurements to better understand N2O emission relationships to plant NRE and N uptake.

  1. Implementation of preference ranking organization method for enrichment evaluation (Promethee) on selection system of student’s achievement

    Science.gov (United States)

    Karlitasari, L.; Suhartini, D.; Nurrosikawati, L.

    2018-03-01

    Selection of Student Achievement is conducted every year, starting from the level of Study Program, Faculty, to University, which then rank one will be sent to Kopertis level. The criteria made for the selection are Academic and Rich Scientific, Organizational, Personality, and English. In order for the selection of Student Achievement is Objective, then in addition to the presence of the jury is expected to use methods that support the decision to be more optimal in determining the Student Achievement. One method used is the Promethee Method. Preference Ranking Organization Method for Enrichment Evaluation (Promethee) is a method of ranking in Multi Criteria Decision Making (MCDM). PROMETHEE has the advantage that there is a preference type against the criteria that can take into account alternatives with other alternatives on the same criteria. The conjecture of alternate dominance over a criterion used in PROMETHEE is the use of values in the relationships between alternative ranking values. Based on the calculation result, from 7 applicants between Manual and Promethee Matrices, rank 1, 2, and 3, did not change, only 4 to 7 positions were changed. However, after the sensitivity test, almost all criteria experience a high level of sensitivity. Although it does not affect the students who will be sent to the next level, but can bring psychological impact on prospective student’s achievement

  2. The Staff Perceptions of Behavior and Discipline Survey: A Tool to Help Achieve Systemic Change through Schoolwide Positive Behavior Support

    Science.gov (United States)

    Feuerborn, Laura L.; Tyre, Ashli D.; King, Joe P.

    2015-01-01

    The practices of schoolwide positive behavior support (SWPBS) are dependent on staff implementation in classroom and common areas throughout the school. Thus, gaining the support and commitment of school staff is a critical step toward reaching full implementation of SWPBS. However, achieving buildingwide support can be challenging; many schools…

  3. Report on achievements in fiscal 1999 on research and development of the Welfare Techno-system (Shiga); 1999 nendo Welfare Techno system kenkyu kaihatsu (Shiga) seika hokokusho

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-03-01

    Research and development has been performed on a welfare device system that meets the regional needs at the Welfare Techno-house Shiga for the purpose of assisting autonomy in help requiring persons, assisting their social activities, and reducing burdens on helpers. This paper summarizes the achievements in fiscal 1999. In developing a walking action supporting appliance of muscular strength utilizing type, the relationship was investigated between motions of knee joints and muscular output when going up the stairs to perform discussions, experiments and measurements on timing for using auxiliary strength required when the knee joints are bent and stretched. In developing an auxiliary device to support spontaneous movements of lower leg handicapped persons, the standing up motion from the sitting position was analyzed, an action supporting device was designed for the method to help the transfer action, and for transfer actions in vertical and forward-backward directions, and fabrication and experiment were executed thereon. In developing a long-term action and physical condition monitoring system, discussions were given on methods to monitor body action amount and activities in daily life of the subjects, by receiving signals from an acceleration sensor fitted to the front of waist of a subject into a portable digital biological signal monitor. (NEDO)

  4. Report on achievements in fiscal 1999. Research and development of nanometer controlled optical disk system; 1999 nendo nanometer seigyo hikari disk system no kenkyu kaihatsu seika hokokusho

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-03-01

    Organizational strengthening is urged in industrial technological power in information recording area which is comparable with information communications being the main pillar of the innovation in the information technology in Japan. Extremely large expectations and heavy responsibilities are placed on the next generation optical memory technology, which is one of the strong points of Japan who plays a part in the above information recording area. The present project has been performing organizational research and development to achieve creation of new industries, with the following research themes as the main subjects: (1) nanometer controlled optical memory technology, (2) magnetic section responsive and three-dimensional optical memory, (3) ultra precision pit depicting technology, and (4) ultra precision pit measuring technology. The project is two years old this year, in which it was aimed to 'develop an optical memory technology with recording density of 100 Gb/in{sup 2} or more, transfer velocity of 100 Mbps or higher, and access time of 10 ms or less'. In order to achieve and establish the interim target set for fiscal 2000 among the above aims, intending 'trial fabrication of a disk having recording density of 40 to 50 Gb/in{sup 2}, the technical problem extraction and the specifications to realize a 100 Gb/in{sup 2} system', fiscal 1999 has performed researches on 'density and accuracy improvement on the prototype disk by improving the existing devices and introducing new devices'. This paper reports the developmental research theme No. 1. (NEDO)

  5. Achieving excellence in training

    International Nuclear Information System (INIS)

    Mangin, A.M.; Solymossy, J.M.

    1983-01-01

    Operating a nuclear power plant is a uniquely challenging activity, requiring a high degree of competence from all who are involved. Achieving and maintaining this competence requires excellence in training. But what does excellence mean, and how do we achieve it. Based on the experience gained by INPO in plant training evaluations and accreditation activities, this paper describes some of the actions that can be taken to achieve the quality appropriate for nuclear power plant training. These actions are discussed in relation to the four phases of a performance-based training system: (1) needs analysis, (2) program design and development, (3) implementation, and (4) evaluation and improvement

  6. Report on achievements of research and development of an automatic sewing system in fiscal 1985. Total system; 1985 nendo jido hosei system no kenkyu kaihatsu seika hokokusho. Total system

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1986-03-01

    This paper describes the total system, extracted from the achievement report for fiscal 1985 on developing an automatic sewing system. In the study of automating the production system by apparel types, basic and multiple type developments were studied on five representative types of apparels by fiscal 1984. As a result, fiscal 1985 has made it possible to narrow the trial wear down to one type which incorporates characteristics of the five apparel types. It was made possible to focus the study on this type to perform the automation study on the sewing system. Automation procedure was made clear step by step on the series of works including collar fitting, sleeve fitting, side matching, and hem processing as the three-dimensional sewing system being the core technology in the automatic sewing system. Studies from the hardware aspect were executed in the process formation utilizing the new technologies. In the automation study from the production system point of view, the FMS and FA technologies were utilized, and device control was advanced by using NC as the base. In order to complete the study, networking of information and software are important. A simulation program was prepared for the optimized sewing process mixed flexible flow, which incorporates multi-functional stations. (NEDO)

  7. Aggressive behavior, protective factors and academic achievement at students inside and outside the system of institutional care

    OpenAIRE

    Maretić Edita; Sindik Joško

    2013-01-01

    The aim of the study was to determine the differences between the aspects of aggressive behavior, their strengths (protective factors) in the prevention of behavioral disorders and academic achievement, in children within and out of institutional forms of education. The study was conducted on a sample of 264 students in seventh and eighth class of elementary school, of whom 134 were in institutional care, while 130 were outside the institutional forms of education. Data were collected by a qu...

  8. Technical assistance from state health departments for communities engaged in policy, systems, and environmental change: the ACHIEVE Program.

    Science.gov (United States)

    Hefelfinger, Jenny; Patty, Alice; Ussery, Ann; Young, Walter

    2013-10-24

    This study assessed the value of technical assistance provided by state health department expert advisors and by the staff of the National Association of Chronic Disease Directors (NACDD) to community groups that participated in the Action Communities for Health, Innovation, and Environmental Change (ACHIEVE) Program, a CDC-funded health promotion program. We analyzed quantitative and qualitative data reported by community project coordinators to assess the nature and value of technical assistance provided by expert advisors and NACDD staff and the usefulness of ACHIEVE resources in the development and implementation of community action plans. A grounded theory approach was used to analyze and categorize phrases in text data provided by community coordinators. Open coding placed conceptual labels on text phrases. Frequency distributions of the quantitative data are described and discussed. The most valuable technical assistance and program support resources were those determined to be in the interpersonal domain (ie, interactions with state expert advisors, NACDD staff, and peer-to-peer support). The most valuable technical assistance events were action institutes, coaches' meetings, webinars, and technical assistance conference calls. This analysis suggests that ACHIEVE communities valued the management and training assistance provided by expert advisors and NACDD staff. State health department expert advisors provided technical guidance and support, including such skills or knowledge-based services as best-practice strategies, review and discussion of community assessment data, sustainability planning, and identification of possible funding opportunities. NACDD staff led development and implementation of technical assistance events.

  9. Learning Behaviours of Low-Achieving Children's Mathematics Learning in Using of Helping Tools in a Synchronous Peer-Tutoring System

    Science.gov (United States)

    Tsuei, Mengping

    2017-01-01

    This study examined the effects of low-achieving children's use of helping tools in a synchronous mathematics peer-tutoring system on the children's mathematics learning and their learning behaviours. In a remedial class, 16 third-grade students in a remedial class engaged in peer tutoring in a face-to-face synchronous online environment during a…

  10. Accelerators/decelerators of achieving universal access to sexual and reproductive health services: a case study of Iranian health system.

    Science.gov (United States)

    Akbari, Nahid; Ramezankhani, Ali; Pazargadi, Mehrnoosh

    2013-07-01

    At the 1994 International Conference on Population and Development (ICPD), held in Cairo, the global community agreed to the goal of achieving universal access to sexual and reproductive health (SRH) and rights by 2015. This research explores the accelerators and decelerators of achieving universal access to the sexual and reproductive health targets and accordingly makes some suggestions. We have critically reviewed the latest national reports and extracted the background data on each SRH indicator. The key stakeholders, both national and international, were visited and interviewed at two sites. A total of 55 in-depth interviews were conducted with religious leaders, policy-makers, senior managers, senior academics, and health care managers. Six focus-group discussions were also held among health care providers. The study was qualitative in nature. Obstacles on the road to achieving universal access to SRH can be viewed from two perspectives. One gap exists between current achievements and the targets. The other gap arises due to age, marital status, and residency status. The most recently observed trends in the indicators of the universal access to SRH shows that the achievements in the "unmet need for family planning" have been poor. Unmet need for family planning could directly be translated to unwanted pregnancies and unwanted childbirths; the former calls for sexual education to underserved people, including adolescents; and the latter calls for access to safe abortion. Local religious leaders have not actively attended international goal-setting programs. Therefore, they usually do not presume a positive attitude towards these goals. Such negative attitudes seem to be the most important factors hindering the progress towards universal access to SRH. Lack of international donors to fund for SRH programs is also another barrier. In national levels both state and the society are interactively playing their roles. We have used a cascade model for presenting the

  11. Report on achievements in fiscal 1999 on research and development of the Welfare Techno-system (Shizuoka); 1999 nendo Welfare Techno system kenkyu kaihatsu (Shizuoka) seika hokokusho

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-03-01

    Research and development has been performed at the Shizuoka Welfare Techno-house to assist entry into the welfare industry field of the local industries in the prefecture, such as for wood products, furniture and music instruments, and to provide products which take into consideration the society with more elderly people and less children. This paper summarizes the achievements in fiscal 1999. In developing barrier-free kitchens capable of handling change in bodily functions, a prototype kitchen was used to evaluate work load variation as a result of existence of a foot space under the kitchen table. In addition, a human simulation software was used to evaluate compatibility of humans with products. By utilizing these technical data, a system was arranged by which barrier-free kitchens can be commercialized by changing the specifications according to individual requirements. In developing a bed unit to prevent bedsore by using the multi-point pressure and fluctuation mechanism, the unit weight was reduced, and addition was made to such functions as controlling finger-pressing cycle and positions by electronic control. Development was made on a music instrument for rehabilitation by which anyone can play music by repetitively giving stimulation to human eyes and ears. (NEDO)

  12. Report on achievements in fiscal 1999 on research and development of the Welfare Techno-system (Niihama); 1999 nendo Welfare Techno system kenkyu kaihatsu (Niihama) seika hokokusho

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-03-01

    Research and development has been performed on a welfare techno-system that takes into account the interface between houses themselves and welfare devices and between the welfare devices to perform without troubles the life actions in houses such as movement, excretion and bathing. This paper summarizes the achievements in fiscal 1999. In developing a bath tub that promotes autonomous life for handicapped elderly people, data were collected on bath tubs having been fabricated on the trial basis in the previous fiscal year, problems were extracted, and a shape of a corner-installed type bath tub for home use was decided. In developing a reclining transfer-assisting wheelchair, the wheelchair developed in the previous fiscal year was added with the function by which a wheelchair can be reclined to an optional angle by using person's own force. In developing a horizontally transferring wheelchair, improvement was made on the mechanism to transfer a person from a wheelchair to a bed, resulting in a good result that it can be operated by one helper. In developing a wheelchair accommodating lifter, a lifter was developed that allows a wheelchair to be accommodated easily into the trunk of a passenger car even by one female helper. Research and development was also performed on a portable letter reading device for sight handicapped persons. (NEDO)

  13. Empirical investigation to explore factors that achieve high quality of mobile learning system based on students’ perspectives

    Directory of Open Access Journals (Sweden)

    Mohammed Amin Almaiah

    2016-09-01

    Full Text Available This study presents three frameworks for mobile learning system based on quality factors derived from the updated DeLone and McLean information system success model. This study used the questionnaire as a quantitative method to explore quality factors for mobile learning system based on perspectives of 392 students. This study opens future work for using the identified quality factors as guidelines for researchers and designers to design and develop mobile learning applications.

  14. Hardware resilience: a way to achieve reliability and safety in new nuclear reactors I and C systems

    Energy Technology Data Exchange (ETDEWEB)

    Farias, Marcos S.; Carvalho, Paulo Victor R. de, E-mail: msantana@ien.gov.br, E-mail: paulov@ien.gov.br [Instituto de Engenharia Nuclear (IEN/CNEN-RJ), Rio de Janeiro, RJ (Brazil). Divisão de Engenharia Nuclear. Serviço de Instrumentação; Nedjah, Nadia, E-mail: nadia@eng.uerj.br [Universidade do Estado do Rio de Janeiro (UERJ), Rio de Janeiro, RJ (Brazil). Departamento de Engenharia de Sistemas e Telecomunicações

    2017-07-01

    The idea that systems have a property called ‘resilience’ has emerged in the last decade [1]. In this paper we intend to bring the idea of resilient systems for the hardware applied in safety-critical systems, such as the new nuclear reactor instrumentation and control (I and C) systems. The new systems (based in hardware description language (HDL) programmable devices) have been developed in response to the obsolescence of old analog technologies and current microprocessor-based digital technologies. Although HDL programmable devices have been widely used in various other industries for decades, they are still very new in nuclear reactors systems, which can be seen as a challenge and risk in the safety analyses and licensing efforts for utilities and designers. The goal of this work is to develop and test hardware architectures to tolerate the occurrence of faults, including multiple faults, minimizing the impact of the recovery process on system availability. Basic concepts of resilience in complex systems, as 'return to equilibrium', 'robustness' and 'extra adaptive capacity' were analyzed from the point of view of hardware architectures, leading to linkages between concepts and methods for resilience using an approach that increases reliability and simplifies the licensing process of systems based in HDL programmable devices in nuclear plants. (author)

  15. Nonlinear Control of an Active Magnetic Bearing System Achieved Using a Fuzzy Control with Radial Basis Function Neural Network

    Directory of Open Access Journals (Sweden)

    Seng-Chi Chen

    2014-01-01

    Full Text Available Studies on active magnetic bearing (AMB systems are increasing in popularity and practical applications. Magnetic bearings cause less noise, friction, and vibration than the conventional mechanical bearings; however, the control of AMB systems requires further investigation. The magnetic force has a highly nonlinear relation to the control current and the air gap. This paper proposes an intelligent control method for positioning an AMB system that uses a neural fuzzy controller (NFC. The mathematical model of an AMB system comprises identification followed by collection of information from this system. A fuzzy logic controller (FLC, the parameters of which are adjusted using a radial basis function neural network (RBFNN, is applied to the unbalanced vibration in an AMB system. The AMB system exhibited a satisfactory control performance, with low overshoot, and produced improved transient and steady-state responses under various operating conditions. The NFC has been verified on a prototype AMB system. The proposed controller can be feasibly applied to AMB systems exposed to various external disturbances; demonstrating the effectiveness of the NFC with self-learning and self-improving capacities is proven.

  16. A solvent/non-solvent system for achieving solution-processed multilayer organic light-emitting devices

    Energy Technology Data Exchange (ETDEWEB)

    Yu, Yue; Wu, Zhaoxin, E-mail: zhaoxinwu@mail.xjtu.edu.cn; He, Lin; Jiao, Bo; Hou, Xun

    2015-08-31

    We developed a solvent/non-solvent system to fabricate the multilayer organic light-emitting devices (OLEDs) based on poly(N-vinylcarbazole) (PVK) by solution-process. This solvent system consists of both the solvent and non-solvent of PVK, in which fluorescent small molecules could be fully dissolved and directly spin-coated on top of the PVK layer; it could effectively avoid the redissolution of PVK during the spin-coating process of small molecules emitting layer. In the further investigation of this system, we also demonstrated the three-component solvent system, and found out that the third component, a less volatile solvent of PVK, was crucial for preparing a smoother interface between PVK and emitting layer. Compared with OLEDs through the vacuum deposition, the devices fabricated by solution-process from the solvent/non-solvent system showed comparable efficiency, which indicate that the solvent/non-solvent system can be used as an alternative process to prepare the polymer and small molecule multilayer devices through all-solution-process. - Highlights: • We fabricate the multilayer OLEDs by solution-process using a novel system. • We develop a solvent/non-solvent system of polymer (PVK) to avoid redissolution. • Small molecules could be fully dissolved and directly spin-coated on PVK layer. • The devices fabricated by the system and vacuum deposition show comparable efficiency.

  17. Hardware resilience: a way to achieve reliability and safety in new nuclear reactors I and C systems

    International Nuclear Information System (INIS)

    Farias, Marcos S.; Carvalho, Paulo Victor R. de; Nedjah, Nadia

    2017-01-01

    The idea that systems have a property called ‘resilience’ has emerged in the last decade [1]. In this paper we intend to bring the idea of resilient systems for the hardware applied in safety-critical systems, such as the new nuclear reactor instrumentation and control (I and C) systems. The new systems (based in hardware description language (HDL) programmable devices) have been developed in response to the obsolescence of old analog technologies and current microprocessor-based digital technologies. Although HDL programmable devices have been widely used in various other industries for decades, they are still very new in nuclear reactors systems, which can be seen as a challenge and risk in the safety analyses and licensing efforts for utilities and designers. The goal of this work is to develop and test hardware architectures to tolerate the occurrence of faults, including multiple faults, minimizing the impact of the recovery process on system availability. Basic concepts of resilience in complex systems, as 'return to equilibrium', 'robustness' and 'extra adaptive capacity' were analyzed from the point of view of hardware architectures, leading to linkages between concepts and methods for resilience using an approach that increases reliability and simplifies the licensing process of systems based in HDL programmable devices in nuclear plants. (author)

  18. How Academic Health Systems Can Achieve Population Health in Vulnerable Populations Through Value-Based Care: The Critical Importance of Establishing Trusted Agency.

    Science.gov (United States)

    Wesson, Donald E; Kitzman, Heather E

    2018-01-16

    Improving population health may require health systems to proactively engage patient populations as partners in the implementation of healthy behaviors as a shared value using strategies that incentivize healthy outcomes for the population as a whole. The current reactive health care model, which focuses on restoring the health of individuals after it has been lost, will not achieve the goal of improved population health. To achieve this goal, health systems must proactively engage in partnerships with the populations they serve. Health systems will need the help of community entities and individuals who have the trust of the population being served to act on behalf of the health system if they are to achieve this effective working partnership. The need for these trusted agents is particularly pertinent for vulnerable and historically underserved segments of the population. In this Invited Commentary, the authors discuss ways by which health systems might identify, engage, and leverage trusted agents to improve the health of the population through value-based care.

  19. Report on achievements of research and development of an automatic sewing system in fiscal 1986. System management and control technology; 1986 nendo jido hosei system no kenkyu kaihatsu seika hokokusho. System kanri seigyo gijutsu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1987-03-01

    The Automatic Sewing System Technology Research Association was commissioned from the Agency of Industrial Science and Technology on the 'development of an automatic sewing system'. The association is performing the research and development by dividing the subject into such component technologies as a total system and sewing preparation and processing technology, a sewing and assembling technology, a cloth handling technology, and a system management and control technology. This paper reports the achievement of the research and development on the system management and control technology. Plans have been established on the following items: dimensional inspection of sewn parts by using an image processing technology, real-time processing of the matching work interlocked with a striped pattern cloth handling device, and a processing positioning algorithm to instruct sewing lines and needle dropping points based on contour lines of pockets and collars. The effects thereof were verified. Printing seven-segmented numerals on cloth by using fluorescent whitener and an automatic reading test of the printed information verified that the technology can be applied to tracking the parts in a processing line as an ID information. Researches were also made on unification of micro-computers for controlling such automatic machines as a multi-functional sewing machine, a three-dimensional sewing machine, and a cloth handling and positioning device, as well as on interface with the computer for function sharing management and control. (NEDO)

  20. Report on achievements of research and development of an automatic sewing system in fiscal 1986. System management and control technology; 1986 nendo jido hosei system no kenkyu kaihatsu seika hokokusho. System kanri seigyo gijutsu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1987-03-01

    The Automatic Sewing System Technology Research Association was commissioned from the Agency of Industrial Science and Technology on the 'development of an automatic sewing system'. The association is performing the research and development by dividing the subject into such component technologies as a total system and sewing preparation and processing technology, a sewing and assembling technology, a cloth handling technology, and a system management and control technology. This paper reports the achievement of the research and development on the system management and control technology. Plans have been established on the following items: dimensional inspection of sewn parts by using an image processing technology, real-time processing of the matching work interlocked with a striped pattern cloth handling device, and a processing positioning algorithm to instruct sewing lines and needle dropping points based on contour lines of pockets and collars. The effects thereof were verified. Printing seven-segmented numerals on cloth by using fluorescent whitener and an automatic reading test of the printed information verified that the technology can be applied to tracking the parts in a processing line as an ID information. Researches were also made on unification of micro-computers for controlling such automatic machines as a multi-functional sewing machine, a three-dimensional sewing machine, and a cloth handling and positioning device, as well as on interface with the computer for function sharing management and control. (NEDO)

  1. Achieving Better Buying Power through Acquisition of Open Architecture Software Systems for Web-Based and Mobile Devices

    Science.gov (United States)

    2015-05-01

    ecosystems Software component supply network for OA system components: Component IP license and cybersecurity requirements propagate from/to Producers...acquisition and OA development ecosystems: Multiple OA system evolution paths IP and cybersecurity requirements will need continuous attention...acquisition of OA Web/mobile software components  Franchising  Enterprise licensing  Metered usage  Advertising supported  Subscription  Free

  2. Comparison study between a Renewable Energy Supply System and a supergrid for achieving 100% from renewable energy sources in Islands

    DEFF Research Database (Denmark)

    Xydis, George

    2013-01-01

    in combination with the technical restrictions of diesel generators of the existing conventional power stations are a major concern of power supply system. Reversing the roles of diesel generators and wind farms (WFs), to use WF as the basic energy source and diesel generators as stand-by system changed in fact...

  3. Construction of System for Seismic Observation in Deep Borehole (SODB) - Overview and Achievement Status of the Project

    International Nuclear Information System (INIS)

    Kobayashi, Genyu

    2014-01-01

    The seismic responses of each unit at the Kashiwazaki-Kariwa NPP differed greatly during the 2007 Niigata-ken Chuetsu-oki Earthquake; the deep sedimentary structure around the site greatly affected these differences. To clarify underground structure and to evaluate ground motion amplification and attenuation effects more accurately in accordance with deep sedimentary structure, JNES initiated the SODB project. Deployment of a vertical seismometer array in a 3000-meter deep borehole was completed in June 2012 on the premises of NIIT. Horizontal arrays were also placed on the ground surface. Experiences and achievements in the JNES project were introduced, including development of seismic observation technology in deep boreholes, site amplification measurements from logging data, application of borehole observation data to maintenance of nuclear power plant safety, and so on. Afterwards, the relationships of other presentations in this WS, were explained. (authors)

  4. Universal patterns or the tale of two systems? Mathematics achievement and educational expectations in post-socialist Europe.

    Science.gov (United States)

    Bodovski, Katerina; Kotok, Stephen; Henck, Adrienne

    2014-09-01

    Although communist ideology claimed to destroy former class stratification based on labor market capitalist relationships, de facto during socialism one social class hierarchy was substituted for another that was equally unequal. The economic transition during the 1990s increased stratification by wealth, which affected educational inequality. This study examines the relationships among parental education, gender, educational expectations, and mathematics achievement of youths in five post-socialist Eastern European countries, comparing them with three Western countries. We employed the 8 th -grade data from the Trends in International Mathematics and Science Study (TIMSS) 1995 and 2007. The findings point to the universal associations between parental education and student outcomes, whereas gender comparisons present interesting East-West differences. The theoretical and policy implications of these findings are discussed.

  5. Theme--Achieving 2020. Goal 3: All Students Are Conversationally Literate in Agriculture, Food, Fiber, and Natural Resource Systems.

    Science.gov (United States)

    Trexler, Cary, Ed.

    2000-01-01

    Nine theme articles focus on the need for students to be conversationally literate about agriculture, food, fiber, and natural resources systems. Discusses the definition of conversational literacy, the human and institutional resources needed, and exemplary models for promoting literacy. (JOW)

  6. Report on achievements of research and development of an automatic sewing system in fiscal 1985. System management and control technology; 1985 nendo jido hosei system no kenkyu kaihatsu seika hokokusho. System kanri seigyo gijutsu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1986-03-01

    This paper describes the system management and control technology, extracted from the achievement report for fiscal 1985 on developing an automatic sewing system. The comprehensive system management has verified algorithms for the optimal process formation and load balancing based on the industry's latest market and production plan trends, and obtained good results. Furthermore, structuring, discussions and proposals were made on an interface system of an optimal process controlling computer with an automatic device controlling micro computer. The inspection and failure diagnosis have set a quality standard for intermediate products in the sewing lines, and verified that its automation is possible by using an image processing technology that identifies dimensional inspection and colors. In the research of printing control information, calculations were performed on the information amount, printing locations, expression method and printing speed, narrowing down to parts ID and location information as the required printing information. Thus,items of basic information for media, media printing and printing device design were put into order. The information recognizing technology has picked up image recognition applying locations in a sewing factory and problems therein, and performed evaluation experiments on specific pattern matching and processing position recognition to have obtained the prospect of application of the automation. (NEDO)

  7. Report on achievements of research and development of an automatic sewing system in fiscal 1985. System management and control technology; 1985 nendo jido hosei system no kenkyu kaihatsu seika hokokusho. System kanri seigyo gijutsu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1986-03-01

    This paper describes the system management and control technology, extracted from the achievement report for fiscal 1985 on developing an automatic sewing system. The comprehensive system management has verified algorithms for the optimal process formation and load balancing based on the industry's latest market and production plan trends, and obtained good results. Furthermore, structuring, discussions and proposals were made on an interface system of an optimal process controlling computer with an automatic device controlling micro computer. The inspection and failure diagnosis have set a quality standard for intermediate products in the sewing lines, and verified that its automation is possible by using an image processing technology that identifies dimensional inspection and colors. In the research of printing control information, calculations were performed on the information amount, printing locations, expression method and printing speed, narrowing down to parts ID and location information as the required printing information. Thus,items of basic information for media, media printing and printing device design were put into order. The information recognizing technology has picked up image recognition applying locations in a sewing factory and problems therein, and performed evaluation experiments on specific pattern matching and processing position recognition to have obtained the prospect of application of the automation. (NEDO)

  8. Rolling Up the Sheet: Constructing Metal–Organic Lamellae and Nanotubes from a [{Mn 3 (propanediolato) 2 }(dicyanamide) 2 ] n Honeycomb Skeleton

    KAUST Repository

    Wu, Gang; Bai, Jiaquan; Jiang, Yuan; Li, Guanghua; Huang, Jian; Li, Yi; Anson, Christopher E.; Powell, Annie K.; Qiu, Shilun

    2013-01-01

    of individual layers and to enhance surface areas and optimize host-guest interactions to accommodate bigger guests, spontaneous rolling up to form a tubular structure was achieved. © 2013 American Chemical Society.

  9. Automated Storage Retrieval System (ASRS) Role Towards Achievement of Safety Objective and Safety Culture in Radioactive Storage Facilities

    International Nuclear Information System (INIS)

    Mohamad Hakiman Mohd Yusoff; Nurul Wahida Ahmad Khairuddin; Nik Marzukee Nik Ibrahim; Mat Bakar Mahusin; Muhammad, Z.A.; Nur Azna Mahmud; Norfazlina Zainal Abidin

    2012-01-01

    Waste Technology Development Centre (WasTeC) has been awarded with quality management system ISO 9001:2000 in June 2004 or now known as ISO 9001:2008. The scope of the unit's ISO certification is radioactive waste management and storage of radioactive material. To meet the objectives and requirements ISO 9001:2008, WasTeC has started a project known as Automated Storage and Retrieval System (ASRS). ASRS is a computing controlled method for automatically depositing and retrieving waste from defined locations. The system is used to replace the existing process of storage and retrieval of radioactive waste at storage facility at block 33.The main objective of this project is to reduced the radiation exposure to the worker and potential forklift accident occur during storage and retrieval of the radioactive waste. By using the ASRS system, WasTeC/ Nuclear Malaysia can provide a safe storage of radioactive waste and the use of this system can eliminate the repeat handling and can improve productivity. (author)

  10. The information system of learning quality control in higher education institutions: achievements and problems of European universities

    Directory of Open Access Journals (Sweden)

    Orekhova Elena

    2016-01-01

    Full Text Available The article deals with the main trends in the development of the system of learning quality control connected with the European integration of higher education and the democratization of education. The authors analyze the state of information systems of learning quality control existing in European higher education and identify their strong and weak points. The authors show that in the learning process universities actively use innovative analytic methods as well as modern means of collecting, storing and transferring information that ensure the successful management of such a complex object as the university of the 21st century.

  11. Radiative heat transfer enhancement using geometric and spectral control for achieving high-efficiency solar-thermophotovoltaic systems

    Science.gov (United States)

    Kohiyama, Asaka; Shimizu, Makoto; Yugami, Hiroo

    2018-04-01

    We numerically investigate radiative heat transfer enhancement using spectral and geometric control of the absorber/emitter. A high extraction of the radiative heat transfer from the emitter as well as minimization of the optical losses from the absorber leads to high extraction and solar thermophotovoltaic (STPV) system efficiency. The important points for high-efficiency STPV design are discussed for the low and high area ratio of the absorber/emitter. The obtained general guideline will support the design of various types of STPV systems.

  12. Aggressive behavior, protective factors and academic achievement at students inside and outside the system of institutional care

    Directory of Open Access Journals (Sweden)

    Maretić Edita

    2013-01-01

    Full Text Available The aim of the study was to determine the differences between the aspects of aggressive behavior, their strengths (protective factors in the prevention of behavioral disorders and academic achievement, in children within and out of institutional forms of education. The study was conducted on a sample of 264 students in seventh and eighth class of elementary school, of whom 134 were in institutional care, while 130 were outside the institutional forms of education. Data were collected by a questionnaire, which included two measuring instruments: Check-list of advantages and Buss & Perry Aggression Questionnaire (AQ. The children who live in institutional care showed a higher incidence of aggressive behavior, compared with children who are out of institutional care. Children placed in institutional care have less protective factors for the prevention of behavioral disorders, worse general school success, as well as poorer success in Nature/ Biology, compared to non-institutional children. A negative and statistically significant relationship was found between the incidence of aggressive behaviors and protective factors in the prevention of conduct disorder, as well as between the incidence of aggressive behavior and overall school success. A significant positive correlation was found between the protective factors and success in the English language. The results indicate the necessity to consider alternative forms of care for children without parental care, in close cooperation of all relevant institutions and individuals who take care for children.

  13. Intermediate Trends in Math and Science Partnership-Related Changes in Student Achievement with Management Information System Data

    Science.gov (United States)

    Dimitrov, Dimiter M.

    2009-01-01

    This substudy in the evaluation design of the Math and Science Partnership (MSP) Program Evaluation examines student proficiency in mathematics and science for the MSPs' schools in terms of changes across three years (2003/04, 2004/05, and 2005/06) and relationships with MSP-related variables using Management Information System data with the…

  14. Achievement report for fiscal 1998. Esophageal vocalization aid system; 1998 nendo seika hokokusho. Shokudo hassei hojo sochi

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-05-01

    Development has been made on element technologies for an esophageal vocalization aid system. With regard to the speaker, selection and trial production were performed on a speaker used for a phono-coupler to be used in coupling with a telephone transmitter. Performance not differing from that in the currently used telephone set was obtained in the overall characteristics evaluation using a dummy telephone circuitry. For the microphone, two kinds of hands-free microphones were fabricated on a trial basis. In order to develop pitch extraction and amplitude pitch conversion systems, pitch extraction performances were compared and discussed on the following five methods: the auto-correlation method, the Cepstram method, the average magnitude difference function (AMDF) method, the simplified inverse filter tracking (SIFT) method, and the time-domain excitation extractor using minimum perturbation operator (TEMPO) method. The hauling phenomenon, having come up as a problem in an auxiliary digital device, was analyzed to discuss methods for prevention thereof. In developing a voice/unvoiced distinction judgment method, a method using low domain power and high domain power was discussed. Development has been made on exclusive ICs, a voice analyzer, and the using feeling enhancing technology. In developing a total system, a digital unit incorporated esophageal vocalization aid system was developed and improved. (NEDO)

  15. Report on achievements of research and development of an automatic sewing system in fiscal 1988. High-speed laser cutting sub-system; 1988 nendo jido hosei system no kenkyu kaihatsu seika hokokusho. Kosoku laser saidan sub system

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1989-03-01

    This paper describes the achievements in fiscal 1985 of developing an automatic sewing system. The automatic fabric inspection detects and marks automatically defects in cloth that may cause quality defects in sewn products. This information is transmitted so that corrective actions can be taken preventively, and the quality is assured. In order to avoid errors in shifts of defect positions caused by expansion and shrinkage of cloth in each process, a meter marking device was fabricated to allow the positional information to be corrected. Improvement was given on the visual defect detection equipment by using optical means. Cloth cutting is performed mainly by the high-speed laser cutting system, where the knife mesh system is adopted for complementary purpose. Discussions were given on operation method plans for the laser cutting machine. The process is executed sequentially on one belt conveyer shaped honeycomb. An ITV camera is moved on a robot to use the image data therefrom for matching the patterns on cloth. An information printing device was given a basic design, and the printing ink was developed. An information transmission format was set as an item common to different devices. The pitch times in each process were calculated to structure a factory automation network. (NEDO)

  16. Report on achievements of research and development of an automatic sewing system in fiscal 1988. Production systems by apparel types; 1988 nendo jido hosei system no kenkyu kaihatsu seika hokokusho. Fukushubetsu seisan system

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1989-03-01

    This paper describes the production systems by apparel types from among the achievement report for fiscal 1988 on developing an automatic sewing system. Studies were continued on model wears as the experimental objects for the apparel side studies, and the processing manuals were expanded and improved. In order to expand application of the automatic sewing system technology, design studies were moved forward on an experimental plant for five kinds of apparels, namely tops, bottoms, dresses, sports wears and night wears to prepare for the comprehensive operation of the plant. The study items included such items as layout, handling, communications, utilities, and buildings. Factory design drawings and layout drawings were drawn on trial wear experimenting plants by apparel types. In the FA/FMS study, it was decided to study the factory design taking ladies' blazer coats as the object, whereas shortening the production time was discussed, and the device and software specifications were written up. Changing and switching of cloths and sizes for the five apparel types will be performed during the plant operation studies. Cooperation is tightened between subcommittees for adjusting the experimental plant schedule and technical problems. (NEDO)

  17. Heterogeneous but “Standard” Coding Systems for Adverse Events: Issues in Achieving Interoperability between Apples and Oranges

    Science.gov (United States)

    Richesson, Rachel L.; Fung, Kin Wah; Krischer, Jeffrey P.

    2008-01-01

    Monitoring adverse events (AEs) is an important part of clinical research and a crucial target for data standards. The representation of adverse events themselves requires the use of controlled vocabularies with thousands of needed clinical concepts. Several data standards for adverse events currently exist, each with a strong user base. The structure and features of these current adverse event data standards (including terminologies and classifications) are different, so comparisons and evaluations are not straightforward, nor are strategies for their harmonization. Three different data standards - the Medical Dictionary for Regulatory Activities (MedDRA) and the Systematized Nomenclature of Medicine Clinical Terms (SNOMED CT) terminologies, and Common Terminology Criteria for Adverse Events (CTCAE) classification - are explored as candidate representations for AEs. This paper describes the structural features of each coding system, their content and relationship to the Unified Medical Language System (UMLS), and unsettled issues for future interoperability of these standards. PMID:18406213

  18. Achieving Integrated Care for Older People: Shuffling the Deckchairs or Making the System Watertight For the Future?

    Science.gov (United States)

    Harvey, Gill; Dollard, Joanne; Marshall, Amy; Mittinty, Manasi Murthy

    2018-01-01

    Integrated care has been recognised as a key initiative to resolve the issues surrounding care for older people living with multi-morbidity. Multiple strategies and policies have been implemented to increase coordination of care globally however, evidence of effectiveness remains mixed. The reasons for this are complex and multifactorial, yet many strategies deal with parts of the problem rather than taking a whole systems view with the older person clearly at the centre. This approach of fixing parts of the system may be akin to shuffling the deckchairs on the Titanic, rather than dealing with the fundamental reasons why the ship is sinking. Attempts to make the ship more watertight need to be firmly centred on the older person, pay close attention to implementation and embrace approaches that promote collaborative working between all the stakeholders involved. PMID:29626395

  19. Design and implementation of remote robotic control system for nuclear power plant application achieved through kinesthetic force feedback model

    International Nuclear Information System (INIS)

    Roy, D.

    1995-01-01

    The technology of telerobotic control through a universal and transparent Man-Machine Interface is a growing field of robotics research in today's industrial scenario because of its promising application in hazardous and unstructured environments. The joystick, a sophisticated information receiver-translator-transmitter device, serves as a Man-Machine Interface for telerobots. The present paper describes the development paradigms of a remote control system for a planar four degrees-of-freedom joystick following position feed-forward force/torque feedback strategy in a bi-lateral mode. This joystick based control technology is designed to actuate an industrial robot working in nuclear power plant. The remote control system has been illustrated with model, algorithm, electronic hardware and software routines along with experimental results in order to have effective telemanipulation

  20. Quantitative evaluation of environmental factors influencing the dynamics of mercury in the aquatic systems. Highlights and achievements

    International Nuclear Information System (INIS)

    Akagi, Hirokatsu

    2002-01-01

    The development of a combined mercury extraction - speciation technique for total mercury and methylinercury determination in various biological and environmental media have been established to study and evaluate environmental factors influencing the dynamics of mercury in aquatic systems. Comparability studies of the results from the conventional and radiochemical techniques were planned for the 1st year of the CRP. Validation of the radiochemical method will be undertaken during the current CRP because of constraints in obtaining the appropriate radiotracers. The use of radiotracer techniques will be undertaken to investigate the generation and distribution of methylmercury in the river water - sediment systems using 203 Hg. The improved conventional analytical procedure uses the cold vapor atomic absorption spectrometry for the determination of total mercury in biological and environmental samples. For methylmercury determination, samples are analyzed using combined techniques of dithizone extraction and gas chromatograpy with electron capture detection

  1. Controlled Acoustic Bass System (CABS) A Method to Achieve Uniform Sound Field Distribution at Low Frequencies in Rectangular Rooms

    DEFF Research Database (Denmark)

    Celestinos, Adrian; Nielsen, Sofus Birkedal

    2008-01-01

    The sound field produced by loudspeakers at low frequencies in small- and medium-size rectangular listening rooms is highly nonuniform due to the multiple reflections and diffractions of sound on the walls and different objects in the room. A new method, called controlled acoustic bass system (CA......-frequency range. CABS has been simulated and measured in two different standard listening rooms with satisfactory results....

  2. Achieving best practices in national standardisation. A benchmarking study of the national standardisation systems of Finland, Sweden, Denmark and Italy

    International Nuclear Information System (INIS)

    Bonner, P.; Potter, D.

    2000-01-01

    The national standardisation systems of Finland, Sweden, Denmark and Italy have been benchmarked in a study that has sought to identify best practices for improving the performance of all participating bodies. This study has been funded by the Ministry of Trade and Industry of Finland with some assistance from the European Commission. It has involved a series of 27 interviews of some 120 participants at different levels in the standardisation and wider stakeholder communities. This report details the features of each national system and describes more than 50 best practices identified during the course of the study, together with more than 25 recommendations for further improvements that are drawn from best practices in other organisations. The report starts by identifying best practices in the national standardisation systems and their structures and processes before moving onto the participation in European and international standardisation, with their challenges of influence, management and delivery. The relationship with government, at national level and within European programmes, is then addressed before moving onto the financing of standardisation activities within each of the national systems. The focus then starts moving more towards the national standards bodies (SFS,SIS,DS,UNI/CEI) by looking into issues relating to publications and onto customer services, sales and marketing. Management issues and the benefits of a long term strategic approach are then covered before moving on to the issues associated with communications and outreach, not only to those outside of the standards community but also those within it and on its edges. Moreover, trends during the last five years and those expected within the next two are dealt with briefly. A number of recommendations are common to all of the participating bodies. More detailed recommendations and suggested priorities have been made privately in a further set of reports delivered to the participating bodies

  3. The way forward in modernizing the system of radiological protection: achievements and outcomes of the CRPPH expert group (EGRP)

    International Nuclear Information System (INIS)

    McHugh, J.

    2004-01-01

    The considerations and proposals from the CRPPH Expert group, for refining and improving the present system of radiation protection are described. The EGRP considered and built on the foundation provided in the NEA/CRPPH publication 'A Critical Review of the System of Radiation Protection'. In particular it elaborated on the following priority areas: numerical guidance; concepts of regulatory control, exemption and triviality; justification and optimisation; and decision-making and decision aiding. The EGRP report 'The Way Forward is Radiological, Protection' was published in 2002 and has been offered to the wider radiation protection community and to ICRP as input to future recommendations. EGRP suggested that aspects of exclusion, exemption and clearance and triviality could better be addressed through a simplified, but comprehensive process of 'authorization' by regulatory bodies. Recognizing that successful modern decision making on radiation risks increasingly involves stakeholder participation, it would help to identify the circumstances where involvement of 'stakeholders' in decisions would assist, and to characterise the sources and doses where decisions would benefit from stakeholder involvement. These two new ideas should be subjected to 'Road tests' as a trial to see if they would improve the present system of protection. (author)

  4. Estimating the state of a geophysical system with sparse observations: time delay methods to achieve accurate initial states for prediction

    Science.gov (United States)

    An, Zhe; Rey, Daniel; Ye, Jingxin; Abarbanel, Henry D. I.

    2017-01-01

    The problem of forecasting the behavior of a complex dynamical system through analysis of observational time-series data becomes difficult when the system expresses chaotic behavior and the measurements are sparse, in both space and/or time. Despite the fact that this situation is quite typical across many fields, including numerical weather prediction, the issue of whether the available observations are "sufficient" for generating successful forecasts is still not well understood. An analysis by Whartenby et al. (2013) found that in the context of the nonlinear shallow water equations on a β plane, standard nudging techniques require observing approximately 70 % of the full set of state variables. Here we examine the same system using a method introduced by Rey et al. (2014a), which generalizes standard nudging methods to utilize time delayed measurements. We show that in certain circumstances, it provides a sizable reduction in the number of observations required to construct accurate estimates and high-quality predictions. In particular, we find that this estimate of 70 % can be reduced to about 33 % using time delays, and even further if Lagrangian drifter locations are also used as measurements.

  5. Implementation of a compressive sampling scheme for wireless sensors to achieve energy efficiency in a structural health monitoring system

    Science.gov (United States)

    O'Connor, Sean M.; Lynch, Jerome P.; Gilbert, Anna C.

    2013-04-01

    Wireless sensors have emerged to offer low-cost sensors with impressive functionality (e.g., data acquisition, computing, and communication) and modular installations. Such advantages enable higher nodal densities than tethered systems resulting in increased spatial resolution of the monitoring system. However, high nodal density comes at a cost as huge amounts of data are generated, weighing heavy on power sources, transmission bandwidth, and data management requirements, often making data compression necessary. The traditional compression paradigm consists of high rate (>Nyquist) uniform sampling and storage of the entire target signal followed by some desired compression scheme prior to transmission. The recently proposed compressed sensing (CS) framework combines the acquisition and compression stage together, thus removing the need for storage and operation of the full target signal prior to transmission. The effectiveness of the CS approach hinges on the presence of a sparse representation of the target signal in a known basis, similarly exploited by several traditional compressive sensing applications today (e.g., imaging, MRI). Field implementations of CS schemes in wireless SHM systems have been challenging due to the lack of commercially available sensing units capable of sampling methods (e.g., random) consistent with the compressed sensing framework, often moving evaluation of CS techniques to simulation and post-processing. The research presented here describes implementation of a CS sampling scheme to the Narada wireless sensing node and the energy efficiencies observed in the deployed sensors. Of interest in this study is the compressibility of acceleration response signals collected from a multi-girder steel-concrete composite bridge. The study shows the benefit of CS in reducing data requirements while ensuring data analysis on compressed data remain accurate.

  6. Achieving superior band gap, refractive index and morphology in composite oxide thin film systems violating the Moss rule

    International Nuclear Information System (INIS)

    Sahoo, N K; Thakur, S; Tokas, R B

    2006-01-01

    The interrelation between energy gap and high frequency refractive index in semiconductors and dielectrics is manifested by an inverse law which is popularly known as the Moss rule. This semi-empirical relationship is based on the fundamental principle that in a dielectric medium all energy levels are scaled down by a factor of the square of the dielectric constant. Such a rule is obeyed by most pure semiconductors and dielectrics with a few rare violations in composite materials which display several interesting parametric and microstructural evolutions. The present results are based on some specific oxide composite thin films involving Gd 2 O 3 /SiO 2 and ZrO 2 /SiO 2 codeposited systems that have displayed a superior refractive index and energy gaps violating the semi-empirical Moss rule. Also, morphological supremacy is also distinctly noticed in these composites. The novel microstructural and polarizability properties of such composite systems were probed through multi-mode atomic force microscopy and phase modulated spectroscopic ellipsometry using refractive index modelling, autocorrelation and height-height correlation functional analyses. These binary composite thin films have shown their potential as well as the possibility of meeting expectations in satisfying the challenging optical coating requirements of the deep ultraviolet spectral region

  7. NATIC achievement report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-03-01

    This paper reports the achievements of the MAnufacturing Technology supported by advanced and integrated Information system through international Cooperation (MATIC) ended in March 1999. The MATIC project is intended to develop international information systems to support manufacturing process from design to production through an international network in order to upgrade the manufacturing and supporting industries in Asian countries. The project has been completed by support provided by a large number of Japanese corporations and research institutes, and the counterparts in China, Indonesia, Malaysia, Singapore and Thailand. The developed prototype systems cover the three areas of automobile, electronics, textile and apparel industries. Demonstration tests have verified the functions thereof. In the automobile industry field, development was made on a system to link Japanese research and development corporations with Indonesian parts making corporations, and a system to exchange technological data between Indonesia and Thailand. In the electronics industry field, development was performed on an electronic catalog system to link Indonesia, Malaysia, Singapore and Thailand. (NEDO)

  8. European tendencies and co-operation in the field of ITS systems - national achievements and challenges in Hungary

    Directory of Open Access Journals (Sweden)

    Lindenbach Ágnes

    2016-06-01

    Full Text Available The article presents the role of intelligent transport systems/services related to the implementation of the essential European and Hungarian transport policy objectives. The ‘ITS Directive’ will provide a framework for the tasks/works to be performed in the forthcoming years within the priority areas of ITS. The European Commission published regulations / specifications for the priority actions in the form of delegated acts defining the tasks/responsibilities of Member States. Regional/European co-operation for Hungary started after the EU-accession of the country. Hungary was an active partner within the European CONNECT and EasyWay projects, currently Hungary is a member of the CROCODILE consortium.

  9. Elements of product service systems as a potential to achieve a sustainable development: bibliometry and content analysis

    Directory of Open Access Journals (Sweden)

    Rafael Ariente Neto

    2014-08-01

    Full Text Available The concept of product-service systems (PSS is presented as an innovative strategy when offering products and services. It aims at for minimizing environmental impacts through sustainable business models. This study aims to identify which potentialities can be explored with regard to the elements of a PSS in a configuration that favor to offer answers on sustainable issues. To do so, the literature was analyzed by a structured process of bibliographic review. Among the results, three aspects are highlighted: (i the wideness of product concept to add services through PSS life-cycle, (ii the configuration of infra-structure to support a PSS by establishing the necessary communication relatively to logistics services. Finally, the net of actors should be explored to obtain organizational proposals that contribute to PSS performance.

  10. Method for reducing excess heat supply experienced in typical Chinese district heating systems by achieving hydraulic balance and improving indoor air temperature control at the building level

    DEFF Research Database (Denmark)

    Zhang, Lipeng; Gudmundsson, Oddgeir; Thorsen, Jan Eric

    2016-01-01

    A common problem with Chinese district heating systems is that they supply more heat than the actual heat demand. The reason for this excess heat supply is the general failure to use control devices to adjust the indoor temperature and flow in the building heating systems in accordance with the a......A common problem with Chinese district heating systems is that they supply more heat than the actual heat demand. The reason for this excess heat supply is the general failure to use control devices to adjust the indoor temperature and flow in the building heating systems in accordance...... with the actual heat demand. This results in 15-30% of the total supplied heat being lost. This paper proposes an integrated approach that aims to reduce the excess heat loss by introducing pre-set thermostatic radiator valves combined with automatic balancing valves. Those devices establish hydraulic balance...... that once the hydraulic balance is achieved and indoor temperatures are controlled with this integrated approach, 17% heat savings and 42.8% pump electricity savings can be achieved. The energy savings will also have a positive environmental effect with seasonal reductions of 11 kg CO2, 0.1 kg SO2, and 0...

  11. Wireless EEG System Achieving High Throughput and Reduced Energy Consumption Through Lossless and Near-Lossless Compression.

    Science.gov (United States)

    Alvarez, Guillermo Dufort Y; Favaro, Federico; Lecumberry, Federico; Martin, Alvaro; Oliver, Juan P; Oreggioni, Julian; Ramirez, Ignacio; Seroussi, Gadiel; Steinfeld, Leonardo

    2018-02-01

    This work presents a wireless multichannel electroencephalogram (EEG) recording system featuring lossless and near-lossless compression of the digitized EEG signal. Two novel, low-complexity, efficient compression algorithms were developed and tested in a low-power platform. The algorithms were tested on six public EEG databases comparing favorably with the best compression rates reported up to date in the literature. In its lossless mode, the platform is capable of encoding and transmitting 59-channel EEG signals, sampled at 500 Hz and 16 bits per sample, at a current consumption of 337 A per channel; this comes with a guarantee that the decompressed signal is identical to the sampled one. The near-lossless mode allows for significant energy savings and/or higher throughputs in exchange for a small guaranteed maximum per-sample distortion in the recovered signal. Finally, we address the tradeoff between computation cost and transmission savings by evaluating three alternatives: sending raw data, or encoding with one of two compression algorithms that differ in complexity and compression performance. We observe that the higher the throughput (number of channels and sampling rate) the larger the benefits obtained from compression.

  12. What systems are essential to achieving the sustainable development goals and what will it take to marshal them?

    Science.gov (United States)

    Thomas, James C; Silvestre, Eva; Salentine, Shannon; Reynolds, Heidi; Smith, Jason

    2016-12-01

    The sustainable development goal (SDG) for health is linked to 67 indicators, eight times more than their predecessor, the Millenium Development Goals. In many low- and middle-income countries (LMICs), the information infrastructure is not yet able to collect and use the data needed for the indicators. As they seek to be responsive to the SDG agenda, LMICs must not lose sight of their local data needs; they should be cautious about embracing untested electronic technologies for data collection, analysis, and use; carefully balance the care provision and data collection responsibilities of care providers; and use evidence of what works in strengthening their health information systems (HIS). While attending to these concerns, countries can look for instances in which SDG indicators are in sync with their own HIS goals. © The Author 2016. Published by Oxford University Press in association with The London School of Hygiene and Tropical Medicine. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  13. A Human-Automation Interface Model to Guide Automation Design of System Functions: A Way to Achieve Manning Goals in New Systems

    Science.gov (United States)

    2005-12-01

    Manual (Army) FoS Family of Systems FRMV FCS Recovery and Maintenance Vehicle GDLS General Dynamics Land Systems HFE Human Factors Engineering...Thanks goes to our CRADA partners at BAE Systems (formerly UDLP) in Santa Clara, CA. Jeff Powers, Doug Neil, Gene Brennan, and Ron Natividad were eager...above in the HFE implications, MWL can be modeled during system design to assess if it is reasonable throughout system functional flow. Besides

  14. Assessment of the Orion-SLS Interface Management Process in Achieving the EIA 731.1 Systems Engineering Capability Model Generic Practices Level 3 Criteria

    Science.gov (United States)

    Jellicorse, John J.; Rahman, Shamin A.

    2016-01-01

    NASA is currently developing the next generation crewed spacecraft and launch vehicle for exploration beyond earth orbit including returning to the Moon and making the transit to Mars. Managing the design integration of major hardware elements of a space transportation system is critical for overcoming both the technical and programmatic challenges in taking a complex system from concept to space operations. An established method of accomplishing this is formal interface management. In this paper we set forth an argument that the interface management process implemented by NASA between the Orion Multi-Purpose Crew Vehicle (MPCV) and the Space Launch System (SLS) achieves the Level 3 tier of the EIA 731.1 System Engineering Capability Model (SECM) for Generic Practices. We describe the relevant NASA systems and associated organizations, and define the EIA SECM Level 3 Generic Practices. We then provide evidence for our compliance with those practices. This evidence includes discussions of: NASA Systems Engineering Interface (SE) Management standard process and best practices; the tailoring of that process for implementation on the Orion to SLS interface; changes made over time to improve the tailored process, and; the opportunities to take the resulting lessons learned and propose improvements to our institutional processes and best practices. We compare this evidence against the practices to form the rationale for the declared SECM maturity level.

  15. Achievement report on research and development of optics-aided measurement/control system; Hikari oyo keisoku seigyo system no kenkyu kaihatsu ni kansuru hyoka hokokusho

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1986-03-01

    The project aims to establish technologies for putting the above-named system to practical use. Such a system will measure, transmit, and control, with safety and stability by use of optical technologies, industrial process related information to be generated in certain areas such as industrial complexes and very large plants, the information including images, temperatures, flow rates, constituents, etc. Total system evaluation was performed in demonstration tests for appropriateness conducted for 32 systems in fiscal 1980 and 10 systems in fiscal 1981. Studied in the development of element technologies are opto-electronic integrated circuits (OEIC), semiconductor laser devices, light-intercepting devices, optical transmission paths, dielectric light switches, and optical sensors. For OEIC, in particular, since it is believed to be the nucleus of an optical application system, an optical technology joint research office is established, where efforts center on the substrate crystal growth technology, process technology, and crystal/process evaluation technology. (NEDO)

  16. Report on achievements in fiscal 1999 on research and development of the Welfare Techno-system (Kochi); 1999 nendo Welfare Techno system kenkyu kaihatsu (Kochi) seika hokokusho

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-03-01

    With an objective to prevent increase of bedridden elderly people, research and development has been performed on a device to prevent retrogression of walking strength in long-term bedridden people, and on the safety device for a walking training machine. This paper summarizes the achievements in fiscal 1999. In developing the device to prevent retrogression of walking strength, a stepping exercising device was fabricated on a trial basis for two types, a hydraulic type and a timing belt type. Operation experiments were carried out. The hydraulic type device has flexibility when making stepping motions, gives good feeling, and operates smoothly. However, it is difficult to achieve the target values for the weight of 70N and the height of 600 mm. The timing belt type device allows reduction in size and weight, but would not operate smoothly if the brake is applied, requiring improvements in various points. In the research and development of the safety device for a walking training machine, discussions were given on a sensing method for the two typical patterns of a patient falling or tumbling down. As a result, a method was discovered, which has a possibility of identifying to some extent how the falling or tumbling is occurring. The existing walking training machines were modified by adding computers and sensors. (NEDO)

  17. Managing Coil Epoxy Vacuum Impregnation Systems at the Manufacturing Floor Level To Achieve Ultimate Properties in State-of-the-Art Magnet Assemblies

    CERN Document Server

    Hubrig, Jeffrey G

    2005-01-01

    Liquid epoxy resin impregnation systems remain a state-of-the-art polymer material for vacuum and vacuum/pressure impregnation applications in the manufacture of both advanced and conventional coil winding configurations. Epoxy resins inherent latitude in processing parameters accounts for their continued popularity in engineering applications, but also for the tendency to overlook or misinterpret the requisite processing parameters on the manufacturing floor. Resin system impregnation must be managed in detail in order to achieve device life cycle reliability. This closer look reveals how manufacturing floor level management of material acceptance, handling and storage, pre- and post- impregnation processing and cure can be built into a manufacturing plan to increase manufacturing yield, lower unit cost and ensure optimum life cycle performance of the coil.

  18. Three pillars for achieving quantum mechanical molecular dynamics simulations of huge systems: Divide-and-conquer, density-functional tight-binding, and massively parallel computation.

    Science.gov (United States)

    Nishizawa, Hiroaki; Nishimura, Yoshifumi; Kobayashi, Masato; Irle, Stephan; Nakai, Hiromi

    2016-08-05

    The linear-scaling divide-and-conquer (DC) quantum chemical methodology is applied to the density-functional tight-binding (DFTB) theory to develop a massively parallel program that achieves on-the-fly molecular reaction dynamics simulations of huge systems from scratch. The functions to perform large scale geometry optimization and molecular dynamics with DC-DFTB potential energy surface are implemented to the program called DC-DFTB-K. A novel interpolation-based algorithm is developed for parallelizing the determination of the Fermi level in the DC method. The performance of the DC-DFTB-K program is assessed using a laboratory computer and the K computer. Numerical tests show the high efficiency of the DC-DFTB-K program, a single-point energy gradient calculation of a one-million-atom system is completed within 60 s using 7290 nodes of the K computer. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  19. Method for reducing excess heat supply experienced in typical Chinese district heating systems by achieving hydraulic balance and improving indoor air temperature control at the building level

    International Nuclear Information System (INIS)

    Zhang, Lipeng; Gudmundsson, Oddgeir; Thorsen, Jan Eric; Li, Hongwei; Li, Xiaopeng; Svendsen, Svend

    2016-01-01

    A common problem with Chinese district heating systems is that they supply more heat than the actual heat demand. The reason for this excess heat supply is the general failure to use control devices to adjust the indoor temperature and flow in the building heating systems in accordance with the actual heat demand. This results in 15–30% of the total supplied heat being lost. This paper proposes an integrated approach that aims to reduce the excess heat loss by introducing pre-set thermostatic radiator valves combined with automatic balancing valves. Those devices establish hydraulic balance, and stabilize indoor temperatures. The feasibility and the energy consumption reduction of this approach were verified by means of simulation and a field test. By moving the system from centrally planned heat delivery to demand-driven heat delivery, excess heat loss can be significantly reduced. Results show that once the hydraulic balance is achieved and indoor temperatures are controlled with this integrated approach, 17% heat savings and 42.8% pump electricity savings can be achieved. The energy savings will also have a positive environmental effect with seasonal reductions of 11 kg CO_2, 0.1 kg SO_2, and 0.03 kg NO_x per heating square meter for a typical case in Harbin. - Highlights: • Two real cases reflect the temperature and flow control situation of heating systems in China. • Pre-set radiator valves with automatic balancing valves create dynamic hydraulic balance. • IDA-ICE simulation shows 17% heat saving and 48% pump electricity saving. • This approach can improve the comfort level of multi-storey/high-rise residential buildings. • This approach can reduce excess heat supply and bring out positive environmental impacts.

  20. Assessing the influence of knowledge translation platforms on health system policy processes to achieve the health millennium development goals in Cameroon and Uganda: a comparative case study.

    Science.gov (United States)

    Ongolo-Zogo, Pierre; Lavis, John N; Tomson, Goran; Sewankambo, Nelson K

    2018-05-01

    There is a scarcity of empirical data on the influence of initiatives supporting evidence-informed health system policy-making (EIHSP), such as the knowledge translation platforms (KTPs) operating in Africa. To assess whether and how two KTPs housed in government-affiliated institutions in Cameroon and Uganda have influenced: (1) health system policy-making processes and decisions aiming at supporting achievement of the health millennium development goals (MDGs); and (2) the general climate for EIHSP. We conducted an embedded comparative case study of four policy processes in which Evidence Informed Policy Network (EVIPNet) Cameroon and Regional East African Community Health Policy Initiative (REACH-PI) Uganda were involved between 2009 and 2011. We combined a documentary review and semi structured interviews of 54 stakeholders. A framework-guided thematic analysis, inspired by scholarship in health policy analysis and knowledge utilization was used. EVIPNet Cameroon and REACH-PI Uganda have had direct influence on health system policy decisions. The coproduction of evidence briefs combined with tacit knowledge gathered during inclusive evidence-informed stakeholder dialogues helped to reframe health system problems, unveil sources of conflicts, open grounds for consensus and align viable and affordable options for achieving the health MDGs thus leading to decisions. New policy issue networks have emerged. The KTPs indirectly influenced health policy processes by changing how interests interact with one another and by introducing safe-harbour deliberations and intersected with contextual ideational factors by improving access to policy-relevant evidence. KTPs were perceived as change agents with positive impact on the understanding, acceptance and adoption of EIHSP because of their complementary work in relation to capacity building, rapid evidence syntheses and clearinghouse of policy-relevant evidence. This embedded case study illustrates how two KTPs influenced

  1. Achievement report on research and development of medical and welfare equipment technology. Lavatory training system; Iryo fukushi kiki gijutsu kenkyu kaihatsu seika hokokusho. Haisetsu jiritsu shien system

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-11-01

    Research and development of a lavatory training system is carried out to enable bed-ridden aged people to evacuate unaided and thereby to elevate their consciousness of self-reliance. The developed system consists of a multi-functional bed with a built-in transfer unit and a movement assisting system. The multi-functional bed consists of a device that automatically transfers the patient abed to a position on the bedside portable toilet, a device that is remotely controlled to change the posture of the patient from the in-bed state to a seated state, and an audio-visual system that encourages the patient into self-reliance. The movement assisting system enables a patient, who needs people's help in rising from the bed and in walking to the lavatory, to stand up, sit down, and walk, all unaided. The system has undergone field tests at 6 locations in hospitals, public facilities, and residential houses. The result is that for people of Category III it is almost certain that they can travel safely thanks to the system. The system is again evaluated high in barrier-free residential environments. (NEDO)

  2. Achievement report for fiscal 2000 on operational research of human cooperative and coexisting (humanoid) robot system. Operational research of humanoid robot system; 2000 nendo ningen kyocho kyozongata robot system un'yo kenkyu seika hokokusho

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-03-01

    This paper reports the achievements in fiscal 2000 in the operational research of humanoid robot system. Carrying out the development smoothly and efficiently requires accumulation of the operational know-how in both of the periodical check and maintenance and the aspects of hard and software to maintain the functions and performances of the robot platform having been developed in the previous fiscal year. Checks were given on fitting of the fasteners and connectors, batteries, and sensors. Operations were confirmed and adjusted on the liquid crystal projector of the surrounded visual display system for remotely controlled operation, polarization filters, screens, reflector mirrors, and wide viewing angle cameras. Verifications were made on fitting of the arm operation force sensing and presenting system, checks on the mechanical components, and operation of the driving system, whereas no change has been found in the operation for the period of one year, and sufficient performance was identified for the remote robot operation. The virtual robot platform has presented no crash and impediments during erroneous use in the disks of the dynamics simulator and the distributed network processing system. (NEDO)

  3. Achievement report for fiscal 1984 describing research and development of earth resources observation systems; 1984 nendo shigen tansayo kansoku system no kenkyu kaihatsu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1985-03-01

    Japan's Outline of Space Development were renewed in February 1984. Under the new principles, the earth resources satellite (ERS-1) program is to be promoted and that research and development efforts for a launch in fiscal 1989 are to be started. Industrial, academic, and governmental organizations concerned making their utmost efforts have established a Technology Research Association for Resources Remote Sensing for the execution of the tasks. The contents of its business are the research and development of an observation system to be installed aboard ERS-1. That is, a synthetic aperture radar and other equipment such as optical sensors and data transmission systems will be developed, and technologies necessary for the development of a satellite borne observation system will be established through evaluation and verification by testing such systems for instance aboard aircraft. Carried out in fiscal 1984 are the studies of required specifications and the drafting of research and development programs for the next and the following fiscal years involving the research and development of the resources exploration system as a whole, sensor systems, and data transmission systems. (NEDO)

  4. Iterative MMSE Detection for MIMO/BLAST DS-CDMA Systems in Frequency Selective Fading Channels - Achieving High Performance in Fully Loaded Systems

    Science.gov (United States)

    Silva, João Carlos; Souto, Nuno; Cercas, Francisco; Dinis, Rui

    A MMSE (Minimum Mean Square Error) DS-CDMA (Direct Sequence-Code Division Multiple Access) receiver coupled with a low-complexity iterative interference suppression algorithm was devised for a MIMO/BLAST (Multiple Input, Multiple Output / Bell Laboratories Layered Space Time) system in order to improve system performance, considering frequency selective fading channels. The scheme is compared against the simple MMSE receiver, for both QPSK and 16QAM modulations, under SISO (Single Input, Single Output) and MIMO systems, the latter with 2Tx by 2Rx and 4Tx by 4Rx (MIMO order 2 and 4 respectively) antennas. To assess its performance in an existing system, the uncoded UMTS HSDPA (High Speed Downlink Packet Access) standard was considered.

  5. Report on achievements in fiscal 1999 of New Sunshine Project. Development of superconductor power applied technologies. Research on total system; 1999 nendo chodendo denryoku oyo gijutsu kaihatsu gyomu seika hokokusho. Total system nado no kenkyu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-03-01

    To deal effectively with problems being actualized in electric power systems, it is necessary to introduce superconductor technologies into power devices, and achieve higher efficiency, density and stability in the power systems. To achieve the goal, development is being made on superconductor power applied technologies, whereas investigative researches are given on the effects of introducing the superconductor power applied devices to proceed the development effectively and smoothly. This project is also given evaluations on its research achievements. In the practical application of superconductor generators, all of the verification tests have been completed, with the model generator system linkage test as the final test. Design and fabrication technologies were established on a 200,000-kW class pilot generator after having gone through analyses made after the tests. Not only having achieved the initial technical value targets, the result presented reliability required for practical use of the superconductor generator, having exceeded the expectation. The research and development of the superconductor generator technologies under this project is concluded successful. The AC superconductor devices were developed by effectively utilizing the results of the leading researches on fundamental technologies for AC superconductor power device technologies as well as other results of the world's highest levels. (NEDO)

  6. The Classroom Performance System (CPS): Effects on student participation, attendance, and achievement in multicultural anatomy and physiology classes at South Texas College

    Science.gov (United States)

    Termos, Mohamad Hani

    2011-12-01

    The Classroom Performance System (CPS) is an instructional technology tool that increases student performance and addresses different learning styles. Instructional technologies are used to promote active learning; however, student embarrassment issue in a multicultural setting is not addressed. This study assessed the effect of the CPS on student participation, attendance, and achievement in multicultural college-level anatomy and physiology classes at South Texas College, where the first spoken language is not English. Quantitative method and quasi-experimental design were employed and comparative statistic methods and pre-post tests were used to collect the data. Participants were college students and sections of study were selected by convenient sampling. Participation was 100% during most of the lectures held and participation rate did not strike above 68% in control group. Attendance was significantly higher in CPS sections than the control group as shown by t-tests. Experimental sections had a higher increase in the pre-post test scores and student averages on lecture exams increased at a higher rate as compared to the control group. Therefore, the CPS increased student participation, attendance, and achievement in multicultural anatomy and physiology classes. The CPS can be studied in other settings where the first spoken language is English or in other programs, such as special education programs. Additionally, other variables can be studied and other methodologies can be employed.

  7. Recent achievements of SIRGAS

    Science.gov (United States)

    Brunini, C.; Sánchez, L.

    2008-05-01

    SIRGAS is the geocentric reference system for the Americas. Its definition corresponds to the IERS International Terrestrial Reference System (ITRS) and it is realized by a regional densification of the IERS International Terrestrial Reference Frame (ITRF). The SIRGAS activities are coordinated by three working groups: SIRGAS-WGI (Reference System) is committed to establish and maintain a continental-wide geocentric reference frame within the ITRF. This objective was initially accomplished through two continental GPS campaigns in 1995 and 2000, including 58 and 184 stations, respectively. Today, it is realized by around 130 continuously operating GNSS sites, which are processed weekly by the IGS Regional Network Associate Analysis Centre for SIRGAS (IGS- RNAAC-SIR). SIRGAS-WGII (Geocentric Datum) is primarily in charged of defining the SIRGAS geodetic datum in the individual countries, which is given by the origin, orientation and scale of the SIRGAS system, and the parameters of the GRS80 ellipsoid. It is concentrating on promoting and supporting the adoption of SIRGAS in the Latin American and Caribbean countries through national densifications of the continental network. SIRGAS- WGIII (Vertical Datum) is dedicated to the definition and realization of a unified vertical reference system within a global frame. Its central purpose is to refer the geopotential numbers (or physical heights) in all countries to one and the same equipotential surface (W0), which must be globally defined. This includes also the transformation of the existing height datums into the new system. This study shows the SIRGAS achievements of the last two years.

  8. Achieving Better Buying Power through Acquisition of Open Architecture Software Systems. Volume 2 Understanding Open Architecture Software Systems: Licensing and Security Research and Recommendations

    Science.gov (United States)

    2016-01-06

    KWD00], as are  CORBA, Microsoft’s .NET, and Enterprise  Java  Beans.    ● Configured system or sub­system​ – These are software systems built to conform to...background.  55 Some OSS is multiply­licensed, or distributed under two or more licenses. The  MySQL  database  software is distributed either under GPLv2 for...Automation    The license metamodel, calculation, and an assortment of license interpretations are implemented  in a  Java  package. The calculation

  9. Report on achievements of research and development of an automatic sewing system in fiscal 1986. Sewing and assembling technology; 1986 nendo jido hosei system no kenkyu kaihatsu seika hokokokusho. Hosei kumitate gijutsu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1987-03-01

    This paper describes the sewing and assembling technology, extracted from the achievement report for fiscal 1986 on developing an automatic sewing system. The sewing pretreatment technology has made it possible to express performance requirement of inner lining compounded cloths in numerals objectively to some extent. Discussions are being given in different ways on inner lining substituting technologies to improve elasticity and volume feeling in cloths. The high-frequency induction heating system has made it possible to attain bond compounded cloths of high quality. The three-dimensional sewing technology has improved largely the positioning and supporting performances of the automatic sleeve fitting system. A prospect was achieved in the cloth movement amount detecting technology for automatic cloth feed control. A cylindrical form sewing system, which has realized cloth tension control, made a study focussed on the object processes possible in the future. The automatic looper thread feeding type sewing mechanism using the super sewing technology had each function increased in stability, but improvement in maintainability is important when the mechanism is mounded in a sewing machine. The high-function press processing technology will continue its progress into fiscal 1987 by utilizing the achievements made to date, such as utilization of flexible dummies, establishment of pressing conditions, and prototype of a three-dimensional pressing device. (NEDO)

  10. Achievement report on the survey concerning possibility of expansion of ITS technology application to various mobility systems; Kakushu mobility system eno ITS gijutsu tekiyo kakudai kanosei ni kansuru chosa

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-03-01

    The project aims to evaluate the results so far achieved in 'The research and development of ITS (intelligent transportation system) by use of clean energy vehicles' and 'Research and development of ITS technology assisted mobility systems' and the development systems under which the efforts are exerted and to evaluate the possibility of their practical application and the spread of the effects brought about. Ex post facto evaluation is conducted of two types of test systems. The first type includes a rent-a-car for business use in the urban area, a rent-a-car for sightseeing, and a system which is an ITS provided electric car as a domestic second car in the residential district. The second type includes a shuttle bus park-and-ride system and a natural gas fueled physical distribution truck. The result is that the ITS provided electric car system is evaluated high by evaluation committee members. The score lowers in the order of the system for business use in the urban area, the system for sightseeing, and the second car system in the residential district. An electric car reduces its environmental impact when it uses a power generation system that utilizes renewable energy. It has become clear that high convenience will be achieved when a dispatching system is improved for a combination of a 'subminiature electric vehicle and ITS technology' as a method to satisfy the demand for commutation means in case the clientele is one or two people. (NEDO)

  11. Report on achievements in fiscal 1999. System technology to create human life compatible living environment; 1999 nendo ningen kodo tekigogata seikatsu kankyo soshutsu system gijutsu seika hokokusho

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-03-01

    The present research and development is intended to develop the following technology: a system technology to measure, understand and accumulate human activities, analyze objectively the compatibility of human being with products and environments, and support to have the products and working environments comply with activity characteristics of individual persons (a system technology to create human life compatible living environment). Human activities are developed in various scenes, and it is not easy to structure technologies to measure, understand and support the activities common to all of the scenes. Therefore, development will be made on the technologies for measuring, understanding and supporting the activities in the human activity scenes. Development of the manipulative activity complying technology deals with human activities in the scenes to operate devices by which the activities are changed by situation identification and skills in addition to activity characteristics of individual persons. Furthermore, as a scene in which attention to the activity characteristics of individual persons, skills, and external situation is a problem, the automobile driving activities are taken up for discussion, as well as the object building work activities as a scene in which difference in skills of individuals is a problem. (NEDO)

  12. Report on achievements in fiscal 1998. Research and development of a welfare techno-system; 1998 nendo welfare techno system kenkyu kaihatsu (Sapporo) seika hokokusho

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-03-01

    The surveys and studies having been performed in the present fiscal year are as follows: (1) in the surveys and studies on self-reliant and at-home care-taking for elderly people living in residential houses, using biological information of snowy and cold districts as the parameters, (a) effect of changing the attitude in two-step ascent and descent motions was studied, (b) stair ascent and descent motions were analyzed, (c) standing-up motion using a sitting position handrail was analyzed, and (d) stride-over motion patterns and hip joint movements were experimented; (2) in the studies of a living environment system to support self-reliant way of living of elderly and physically handicapped people in snowy and cold districts, studies were made on (a) shapes of entrance and exit spaces of a residential house, and features of moving motions of elderly and physically handicapped people, (b) living activity patterns and pleasantness centering around the living section in the house of the at-home elderly people, (c) forms of approach spaces for independent residential houses that consider snow disposal: (3) in development and improvement of care-taking devices with importance placed on physical and psychological adapting function of the users and harmony with the users, studies were given on (a) noise characteristics of rooms in which at-home welfare devices are installed, (b) colors and recognizability of switches on welfare devices for elderly persons, (c) drive experiments of moving devices in winter, and (d) motion simulation of ridable devices; and studies were made on (4) moving and riding welfare device systems for elderly and physically handicapped people in snowy and cold districts, and (5) user interface of motor-driven wheelchairs. (NEDO)

  13. Building America Residential System Research Results: Achieving 30% Whole House Energy Savings Level in the Hot-Dry and Mixed-Dry Climates

    Energy Technology Data Exchange (ETDEWEB)

    Building Industry Research Alliance (BIRA); Building Science Consortium (BSC); Consortium for Advanced Residential Buildings (CARB); Davis Energy Group (DEG); Florida Solar Energy Center (FSEC); IBACOS; National Association of Home Builders Research Center (NAHBRC); National Renewable Energy Laboratory (NREL)

    2006-01-01

    The Building America program conducts the system research required to reduce risks associated with the design and construction of homes that use an average of 30% to 90% less total energy for all residential energy uses than the Building America Research Benchmark, including research on homes that will use zero net energy on annual basis. To measure the program's progress, annual research milestones have been established for five major climate regions in the United States. The system research activities required to reach each milestone take from 3 to 5 years to complete and include research in individual test houses, studies in pre-production prototypes, and research studies with lead builders that provide early examples that the specified energy savings level can be successfully achieved on a production basis. This report summarizes research results for the 30% energy savings level and demonstrates that lead builders can successfully provide 30% homes in the Hot-Dry/Mixed-Dry Climate Region on a cost neutral basis.

  14. Mental health care delivery system reform in Belgium: the challenge of achieving deinstitutionalisation whilst addressing fragmentation of care at the same time.

    Science.gov (United States)

    Nicaise, Pablo; Dubois, Vincent; Lorant, Vincent

    2014-04-01

    Most mental health care delivery systems in welfare states currently face two major issues: deinstitutionalisation and fragmentation of care. Belgium is in the process of reforming its mental health care delivery system with the aim of simultaneously strengthening community care and improving integration of care. The new policy model attempts to strike a balance between hospitals and community services, and is based on networks of services. We carried out a content analysis of the policy blueprint for the reform and performed an ex-ante evaluation of its plan of operation, based on the current knowledge of mental health service networks. When we examined the policy's multiple aims, intermediate goals, suggested tools, and their articulation, we found that it was unclear how the new policy could achieve its goals. Indeed, deinstitutionalisation and integration of care require different network structures, and different modes of governance. Furthermore, most of the mechanisms contained within the new policy were not sufficiently detailed. Consequently, three major threats to the effectiveness of the reform were identified. These were: issues concerning the relationship between network structure and purpose, the continued influence of hospitals despite the goal of deinstitutionalisation, and the heterogeneity in the actual implementation of the new policy. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  15. Building America Residential System Research Results: Achieving 30% Whole House Energy Savings Level in Mixed-Humid Climates; January 2006 - December 2006

    Energy Technology Data Exchange (ETDEWEB)

    Building America Industrialized Housing Partnership (BAIHP); Building Industry Research Alliance (BIRA); Building Science Consortium (BSC); Consortium for Advanced Residential Buildings (CARB); Davis Energy Group (DEG); IBACOS; National Association of Home Builders Research Center (NAHBRC); National Renewable Energy Laboratory (NREL)

    2006-12-01

    The Building America program conducts the system research required to reduce risks associated with the design and construction of homes that use an average of 30% to 90% less total energy for all residential energy uses than the Building America Research Benchmark, including research on homes that will use zero net energy on annual basis. To measure the program's progress, annual research milestones have been established for five major climate regions in the United States. The system research activities required to reach each milestone take from 3 to 5 years to complete and include research in individual test houses, studies in pre-production prototypes, and research studies with lead builders that provide early examples that the specified energy savings level can be successfully achieved on a production basis. This report summarizes research results for the 30% energy savings level and demonstrates that lead builders can successfully provide 30% homes in the Mixed-Humid Climate Region on a cost-neutral basis.

  16. Achieving a Patient-Centered, Value-Based System of Diabetes Care in the United States: Report on a National Stakeholder Summit

    Science.gov (United States)

    Nash, David B.; Harris, Dennis

    2018-01-01

    Abstract Chronic instability in the health care environment has raised concerns among providers and patients, especially those who treat and cope with chronic conditions. Changes to existing health care laws are unlikely to alter what have become the primary goals of the US health care system: cost-effectiveness and patient-centricity. To that end, it is vital that patient and physician voices be incorporated in policy decisions and, importantly, that access to care and patient-reported outcomes are considered when calculating “value.” Following a discussion of perceived pressures on patient access to information and appropriate treatment for diabetes, a panel of engaged stakeholders in the diabetes community outlined and committed to a collaborative effort aimed at effecting necessary policy changes and ensuring that a patient-centered, value-based system of diabetes care is achieved. The overarching themes that emerged included: (1) patients and physicians must have a stronger voice and a place at the table; (2) a collaborative of multiple organizations is necessary to seize improvement opportunities; and (3) the diabetes community must advocate for population health initiatives around diabetes. PMID:28795910

  17. Achieving a Patient-Centered, Value-Based System of Diabetes Care in the United States: Report on a National Stakeholder Summit.

    Science.gov (United States)

    Nash, David B; Skoufalos, Alexis; Harris, Dennis

    2018-02-01

    Chronic instability in the health care environment has raised concerns among providers and patients, especially those who treat and cope with chronic conditions. Changes to existing health care laws are unlikely to alter what have become the primary goals of the US health care system: cost-effectiveness and patient-centricity. To that end, it is vital that patient and physician voices be incorporated in policy decisions and, importantly, that access to care and patient-reported outcomes are considered when calculating "value." Following a discussion of perceived pressures on patient access to information and appropriate treatment for diabetes, a panel of engaged stakeholders in the diabetes community outlined and committed to a collaborative effort aimed at effecting necessary policy changes and ensuring that a patient-centered, value-based system of diabetes care is achieved. The overarching themes that emerged included: (1) patients and physicians must have a stronger voice and a place at the table; (2) a collaborative of multiple organizations is necessary to seize improvement opportunities; and (3) the diabetes community must advocate for population health initiatives around diabetes.

  18. Report on achievements in fiscal 1998. Survey on environmental effects from photovoltaic power generation systems; 1998 nendo daikibo taiyoko hatsuden system no kankyo eikyo ni kansuru chosa hokokusho

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-03-01

    Different environmental effects may be assumed when large-size photovoltaic power generation systems are installed in vast unutilized lands including deserts. Knowledge having been acquired to date has been put into order on the following subjects as the pre-survey thereon: (1) environmental characteristics of desert areas, (2) discussions on environmental effects from (a) environmental assessment viewpoints, (b) contents of the environmental assessment, and (c) environmental assessment institutions, and (3) the survey policy. In discussing the environmental characteristics, it is revealed that desert areas are neither sterile nor unused, but pasturage and agriculture have been carried out in historical and traditional ways. In discussing the environmental effects, it was recognized that surveys on primary and secondary effects on the environmental are indispensable. With regard to the institutions, there are countries who have and have not the institutions even among the OECD member states. In addition, it was known that environments in the desert areas vary greatly according to the particular areas, whereas there are possibilities of installing the facilities because the effects of the facility locations on the environment are various. Therefore, it was decided to start from the case studies in locations of different types. (NEDO)

  19. Fiscal 2000 achievement report on the research and development of nanometer controlled optical disk system; 2000 nendo nanometer seigyo hikari disk system no kenkyu kaihatsu seika hokokusho

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-03-01

    Development proceeded of nanometer controlled optical memory technologies as part of systematic research and development aiming at the reinforcement of industrial technology power in the field of data recording. Activities were conducted in the four fields of (1) high density signal processing technology, (2) high performance disk materials technology, (3) disk substrate fabrication technology, and (4) signal detection technology. Discussed in field (1) were multivalue ROM (read only memory) disk signal regeneration, SIL-LBR (solid immersion lens-laser beam recorder), dry etching process using RIE (reactive ion etching), SHG (second harmonic generation) blue laser, and a multivalue ROM disk evaluation system. Studied in field (2) were the evaluation of ROM disk performance dependent on recording materials, development of high density recording materials, and the evaluation of crystallization induction time using a static tester. Studied in the development of high density recording materials was the formation of microscopic recording marks in a phase shift/surface recording type disk comprising a 4-element (Ag-In-Sb-Te) recording layer and an Ag reflection layer. In fiscal 2000, an attempt was made at the 0.07 {mu}m level. (NEDO)

  20. Achievement report for fiscal 1981 on solar system survey projects implemented overseas. Singapore and Australia; 1981 nendo solar system kaigai chosa jigyo seika hokokusho. Singapore Australia

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1982-06-01

    During a 20-day survey tour to Singapore and Australia which started on February 7, 1982, visits were paid to 6 universities, 2 national or state research institutes, 2 state government agencies, 6 passive solar facilities, and some industrial societies and solar equipment manufactures. At universities and research institutes, research and experiments are earnestly under way for the development of solar heat collectors, for the research and testing of software programs therefor, and for the research and development of photovoltaic and geothermal power generation systems. In the case of photovoltaic power, in particular, many programs require the construction of pilot plants and simultaneous supply of power to general consumers with tests and experiments continued for the pilot plants for putting the technology to practical use. This is thought to demonstrate the urgent need for measures for out-of-the-way locations. Electric power is priced at 7-8 yen/kWh, approximately half the price in Japan. Marginal supply capability is low because power is generated mainly by coal and no nuclear power is available. Efforts at underground reserves exploitation have become very active and, since there is need to supply power to the back regions, funds are eagerly invested in on-site power generation and photovoltaic power development. In Australia, power supply is monopolized by state governments. Even in Australia, who enjoy 65% self-sufficiency in oil and export a substantial amounts of natural gas and coal, there are enthusiastic efforts at harnessing solar energy. (NEDO)

  1. [Study on interventions based on urban - rural integration system construction to consolidate achievements of schistosomiasis control in hilly schistosomiasis endemic areas].

    Science.gov (United States)

    Rong-Zhi, Li; Yang, Liu; Hui, Zhang; Yi, Zhang; Bo, Zhong; Jian-Jun, Wu; Chun-Xia, Yang

    2017-09-28

    To explore the effectiveness of comprehensive schistosomiasis control interventions based on urban-rural integration system construction to carry out the schistosomiasis control in hilly schistosomiasis endemic areas, so as to offer a new mode to consolidate the achievements of schistosomiasis control in the new situation. Shouan Town and Changqiu Township in Pujiang County in hilly schistosomiasis endemic regions were selected as demonstration areas. The comprehensive schistosomiasis control interventions based on urban-rural integration system construction were implemented, including the land consolidation, centralized residence and so on. The effectiveness the interventions was evaluated. In Shouan Town and Changqiu Township, the transformed environments with Oncomelania hupensis snail habitats were 1 330.61 hm 2 and 1 456.84 hm 2 , the areas with snails decreased from 94.31 hm 2 and 83.00 hm 2 in 2000 to both 0 in 2015, the positive rates of serological tests for schistosomiasis decreased from 11.8% and 7.53% in 2000 to 1.01% and 1.86% in 2015, and the positive rates of parasitological tests decreased from 0.18% and 0.15% in 2000 to both 0 in 2015 respectively. The numbers of cattle decreased from 358 and 368 in 2000 to 4 and 6 in 2015 respectively. In 2000, the schistosome infection rates of cattle were 3.63% and 6.51% in Shouan Town and Changqiu Township respectively, and from 2004, no infected cattle were found. The comprehensive schistosomiasis control interventions based on urban-rural integration system construction can decrease the schistosome infection rate and area with snails effectively, providing a new mode for schistosomiasis elimination.

  2. Report for fiscal 1997 on simple operation type CAD/CAM system development through international cooperation. Research achievements; 1997 nendo 'kan'i sosagata denshi sekkei seisan shien system no kaihatsu ni kansuru kenkyu kyoryoku' ni kansuru hokokusho. Kenkyu seika

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-03-01

    This paper reports the achievements in fiscal 1995 in the research and development project for an electronics design and production aid system of simple operation type (MATIC). The project is intended to support works of Asian countries on the information society, and enhance levels of the manufacturing industries and supportive industries by utilizing the information technologies. The working group (WG)I, related to automobiles and components thereof, improved functions of the primary system and continued demonstration tests. The group launched for the secondary system a system development that makes timely information transmission and receipt possible among research and development enterprises, local assembly enterprises and facility and parts suppliers. The WGII (household appliances and their parts) designed and developed an electronic catalog system based on pre-prototypes developed independently by different countries, and performed demonstration tests. The WGIII (textiles and apparels) carried out with China demonstration tests on the international EDI system, translation system and CAD/CAM system. It also developed a sewing technology standards system. It installed equipment and devices in Indonesia for preparation of the demonstration tests. (NEDO)

  3. Achievement report for fiscal 1976 on Sunshine Program. Research on systems for hydrogen refining, transporting, and storing, and technology for assuring safety; 1976 nendo suiso no seisei yuso chozo system oyobi hoan gijutsu ni kansuru kenkyu seika hokokusho

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1977-03-01

    The results of studies conducted in the 3-year period beginning in fiscal 1974 are collected in this report. Dealt with in Chapter 1 are hydrogen production systems that constitute the stages before and after a hydrogen refining/transporting/storing subsystem, the future outlook of a hydrogen supply system with consideration bestowed on its connection with hydrogen-using systems, and how subsystems involving transportation and storage should be in such a hydrogen supply system. In Chapter 2, for the purpose of helping the construction in the future of a total energy system for hydrogen, the flows of energy and substances in Japan based on the records of fiscal 1974 and charts of the actualities of hydrogen utilization are shown. In Chapter 3, tentative designs of hydrogen supply systems are taken up for assessment. In Chapter 5, subsystems for a hydrogen supply system including topological patterns are tentatively designed. In Chapter 6, the transportation and storage of hydrogen are quantitatively evaluated, and assessment is conducted about investment for the embodiment of a topological model, selection of a profitable system, and environmental safety. Reference is also made in this chapter to research and development policies under which a hydrogen system to be the target is manifestly defined, where the aim of such research and development is declared and the need of its achievement is emphasized. (NEDO)

  4. Integrated Three-Voltage-Booster DC-DC Converter to Achieve High Voltage Gain with Leakage-Energy Recycling for PV or Fuel-Cell Power Systems

    Directory of Open Access Journals (Sweden)

    Chih-Lung Shen

    2015-09-01

    Full Text Available In this paper, an integrated three-voltage-booster DC-DC (direct current to direct current converter is proposed to achieve high voltage gain for renewable-energy generation systems. The proposed converter integrates three voltage-boosters into one power stage, which is composed of an active switch, a coupled-inductor, five diodes, and five capacitors. As compared with conventional high step-up converters, it has a lower component count. In addition, the features of leakage-energy recycling and switching loss reduction can be accomplished for conversion efficiency improvement. While the active switch is turned off, the converter can inherently clamp the voltage across power switch and suppress voltage spikes. Moreover, the reverse-recovery currents of all diodes can be alleviated by leakage inductance. A 200 W prototype operating at 100 kHz switching frequency with 36 V input and 400 V output is implemented to verify the theoretical analysis and to demonstrate the feasibility of the proposed high step-up DC-DC converter.

  5. Achievement report on research and development of medical and welfare equipment technology. Optical tomographic imaging method; Iryo fukushi kiki gijutsu kenkyu kaihatsu seika hokokusho. Hikari danso imaging system

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-11-01

    The aim is to develop a method of processing oxygen concentration distribution in human organs into an image by computed tomography using near infrared rays capable of transmitting through living tissues. Since the photoabsorption spectra of hemoglobin etc. in blood vary according to the degree of their oxidation, an oxygen concentration level is determined by measuring the magnitude of the variation. In the imaging method named in the title, the object is irradiated with picosecond-level near infrared pulses from all directions successively, the pulses after transmission through the object are measured at all directions at a picosecond-level time resolution, and the distribution of pulse scattering and absorption characteristics are subjected to algorithmic calculation, the outcome is converted into oxygen concentration levels, and an image is obtained. A 64-channel time resolution measurement system is constructed, and is applied to living tissue models (phantoms) and animals, and an image is obtained and evaluated. On the basis of the result, a patient is examined for clinical evaluation, and an image reflecting the distribution of variations in hemoglobin oxygen concentration is obtained for the head of the adult patient. A spatial resolution of 1cm is achieved in case of a phantom 10cm in diameter. In the case of 64 channels, measurement takes approximately 20 minutes and mapping image data measurement takes approximately 7 minutes. (NEDO)

  6. BIBLIOGRAPHY ON ACHIEVEMENT.

    Science.gov (United States)

    Harvard Univ., Cambridge, MA. Graduate School of Education.

    THIS BIBLIOGRAPHY LISTS MATERIAL ON VARIOUS ASPECTS OF ACHIEVEMENT. APPROXIMATELY 40 UNANNOTATED REFERENCES ARE PROVIDED TO DOCUMENTS DATING FROM 1952 TO 1965. JOURNALS, BOOKS, AND REPORT MATERIALS ARE LISTED. SUBJECT AREAS INCLUDED ARE BEHAVIOR TESTS, ACHIEVEMENT BEHAVIOR, ACADEMIC ACHIEVEMENT, AND SOCIAL-CLASS BACKGROUND. A RELATED REPORT IS ED…

  7. Electrochemical Evidence of Host-Guest Interactions. Change of Redox Mechanism of Fungicides Iprodione and Procymidone in the Nano-cavity of Cyclodextrins

    Czech Academy of Sciences Publication Activity Database

    Hromadová, Magdaléna; Pospíšil, Lubomír; Giannarelli, S.; Fuoco, R.; Colombini, M. P.

    2002-01-01

    Roč. 73, - (2002), s. 213-219 ISSN 0026-265X R&D Projects: GA MŠk OC D15.10; GA ČR GP203/02/P082 Institutional research plan: CEZ:AV0Z4040901 Keywords : electrochemical evidence * fungicide * cyclodextrin Subject RIV: CG - Electrochemistry Impact factor: 1.325, year: 2002

  8. A facile and flexible process of β-cyclodextrin grafted on Fe3O4 magnetic nanoparticles and host-guest inclusion studies

    International Nuclear Information System (INIS)

    Zhu Jie; He Jiang; Du Xiaoyan; Lu Ruihua; Huang Lizhen; Ge Xia

    2011-01-01

    In this study, a kind of novel surface-functionalized magnetic nanoparticles was fabricated by the Fe 3 O 4 nanoparticles surface modification with mono-6-deoxy-6-(p-tolylsulfonyl)-cyclodextrin (6-TsO-β-CD), which were employed to interact with uric acid and their behavior was investigated by electrochemical methods. The architecture has been characterized by powder X-ray diffraction (XRD), Fourier transform infrared spectra (FT-IR), transmission electron microscopy (TEM), and thermogravimetric analysis (TGA), which confirmed that cyclodextrins have been effectively functionalized on the surface of Fe 3 O 4 nanoparticles. The analyses of vibration sample magnetometer (VSM) verified that the nanoparticles owned good magnetic property. The grafted β-cyclodextrin on the Fe3O4 nanoparticles contributed to as a modified electrode for detecting uric acid with cyclic voltammograms. Electrochemical results revealed that the new materials could exhibit excellent molecules recognition ability and show high electrochemical response. The new nanoparticles simultaneously had unique properties of magnetic nanoparticles and cyclodextrins through combining their individual distinct advantages.

  9. Host-guest complex of N-(2-chloroethyl), N-nitroso, N‧, N‧ -dicyclohexylsulfamid with β-cyclodextrin: Fluorescence, QTAIM analysis and structure-chemical reactivity

    Science.gov (United States)

    Bensouilah, Nadjia; Fisli, Hassina; Bensouilah, Hamza; Zaater, Sihem; Abdaoui, Mohamed; Boutemeur-Kheddis, Baya

    2017-10-01

    In this work, the inclusion complex of DCY/CENS: N-(2-chloroethyl), N-nitroso, N‧, N‧-dicyclohexylsulfamid and β-cyclodextrin (β-CD) is investigated using the fluorescence spectroscopy, PM3, ONIOM2 and DFT methods. The experimental part reveals that DCY/CENS forms a 1:1 stoichiometric ratio inclusion complex with β-CD. The constant of stability is evaluated using the Benesi-Hildebrand equation. The results of the theoretical optimization showed that the lipophilic fraction of molecule (cyclohexyl group) is inside of β-CD. Accordingly, the Nitroso-Chloroethyl moiety is situated outside the cavity of the macromolecule host. The favorable structure of the optimized complex indicates the existence of weak intermolecular hydrogen bonds and the most important van der Waals (vdW) interactions which are studied on the basis of Natural Bonding Orbital (NBO) analysis. The NBO is employed to compute the electronic donor-acceptor exchanges between drug and β-CD. Furthermore, a detailed topological charge density analysis based on the quantum theory of atoms in molecules (QTAIM), has been accomplished on the most favorable complex using B3LYP/6-31G(d) method. The presence of stabilizing intermolecular hydrogen bonds and van der Waals interactions in the most favorable complex is predicted. Also, the energies of these interactions are estimated with Espinosa's formula. The findings of this investigation reveal that the correlation between the structural parameters and the electronic density is good. Finally, and based on DFT calculations, the reactivity of the interesting molecule in free state was studied and compared with that in the complexed state using chemical potential, global hardness, global softness, electronegativity, electrophilicity and local reactivity descriptors.

  10. Biosynthesis of ketomycin. (II) biomimetic model for beta-lactamase catalysis: host-guest interactions in cyclodextrin-penicillin inclusion complex

    International Nuclear Information System (INIS)

    Mak, H.W.

    1986-01-01

    The antibiotic ketomycin is formed from shikimic acid via chorismic acid and prephenic acid. Phenylalanine and 2',5'-dihydrophenylalanine derived from shikimic acid are not intermediates in the biosynthesis. Degradation of ketomycin derived from [1,6- 14 C]shikimic acid showed that prephenic acid is converted into ketomycin with stereospecific discrimination between the two enantiotopic edges of the ring, the pro-S-R edge giving rise to the C-2', C-3' side of the cyclohexane ring of ketomycin. The resistance of pathogenic bacteria to the action of β-lactam antibiotics is mainly ascribed to their ability to produce β-lactamase to cleave the β-lactam ring. It is essential to understand the molecular nature of β-lactamase-penicillin recognition for designing and formulating more effective β-lactam antibiotics. A biomimetic study of β-lactamase is therefore initiated. To meet the requirements of hydrophobic and serine protease characteristics of β-lactamase, α-cyclodextrin is chosen as a biomimetic model for β-lactamase. The structural specificity and the chemical dynamics of α-cyclodextrin-phenoxymethyl penicillin inclusion complex in solid state and in solution have been determined by IR and NMR spectroscopy. The spectral results strongly indicate that the phenyl portion of the phenoxymethyl penicillin forms a stable inclusion complex with the hydrophobic cavity of α-cyclodextrin in solution as well as in the solid state. Kinetic studies followed by 1 HNMR and HPLC analyses under alkaline condition have shown that the α-cyclodextrin mimics the catalytic function of serine of β-lactamase in the stereospecific hydrolysis of the β-lactam ring of phenoxymethyl penicillin

  11. Experimental and theoretical investigations on Pd(II) host-guest compound: Deciphering the structural and electronic features of a potential bioactive complex

    Science.gov (United States)

    Sreejith, S. S.; Mohan, Nithya; Prathapachandra Kurup, M. R.

    2017-10-01

    A Pd(II) complex from N,N‧-bis(2-hydroxy-3-ethoxybenzylidene)butane-1,4-diamine salen-type ligand has been synthesized and characterised using single crystal XRD analysis, elemental analysis, IR and UV-Vis spectroscopic methods. Thermal profile of the compound is investigated using TG-DTG-DSC method. The quantification of intermolecular interactions and surface morphology has been done using Hirshfeld surface study mapped using various functions like dnorm, shape index and curvedness. ESP analysis is done to visualize the electrophilic and nucleophilic regions in the complex. Geometry optimization of the structure is done using DFT at B3LYP/def2-TZVP level of theory. Frontier orbital analysis reveals the kinetical stability and chemical inertness of the complex. A detailed charge distribution analysis is done using different analytical methods like Mulliken, Löwdin, NPA and AIM methods. Further bond order analysis and topological analysis are also done. Finally the bioactivity of the titled complex is checked using molecular docking method on both DNA and protein.

  12. Enhanced detection of explosives by turn-on resonance Raman upon host-guest complexation in solution and the solid state

    DEFF Research Database (Denmark)

    Witlicki, Edward H.; Bähring, Steffen; Johnsen, Carsten

    2017-01-01

    complexation occur via a mechanism of resonance between the 785 nm laser line and the strongly absorbing charge-transfer chromophore arising from the complex between electron-donating TTF-C[4]P and electron-accepting nitroaromatic explosives. The addition of chloride forms the Cl-·TTF-C[4]P complex resetting......The recognition of nitroaromatic explosives by a tetrakis-tetrathiafulvalene-calix[4]pyrrole receptor (TTF-C[4]P) yields a "turn on" and fingerprinting response in the resonance Raman scattering observed in solution and the solid state. Intensity changes in nitro vibrations with analyte...

  13. Achievement report for fiscal 1990 on the research and development of automatic sewing system. Flexible sewing subsystem; 1990 nendo jido hosei system no kenkyu kaihatsu seika hokokusho. Flexible sewing subsystem

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1991-03-01

    An experimental plant systematization study carried out at Tsukuba under the above-named large-scale technological development project is described in the report. All the equipment are carried in, installed, and adjusted; a connection test to the process control computer and a subsystem verification operation are conducted; and then a comprehensive operation/evaluation is conducted, this in cooperation with the apparel hardware manufacturer. As the result, it is confirmed that the subsystem and all the equipment attain the intended levels in every respect of evaluation. Goals are all achieved involving the technologies of high-performance pattern formation, pretreatment for stabilization, multifunctional sewing, measurements for the conveyer system capable of automatic positioning and for the conveyer systems between stations, production control, etc. It is deemed that the research and development effort reported here promises the feasibility of FMS (factory management system), FA (factory automation), and an unmanned plant, which have long been awaited in the apparel business. (NEDO)

  14. Achieving Kaiser Permanente quality.

    Science.gov (United States)

    McHugh, Matthew D; Aiken, Linda H; Eckenhoff, Myra E; Burns, Lawton R

    2016-01-01

    The Kaiser Permanente model of integrated health delivery is highly regarded for high-quality and efficient health care. Efforts to reproduce Kaiser's success have mostly failed. One factor that has received little attention and that could explain Kaiser's advantage is its commitment to and investment in nursing as a key component of organizational culture and patient-centered care. The aim of this study was to investigate the role of Kaiser's nursing organization in promoting quality of care. This was a cross-sectional analysis of linked secondary data from multiple sources, including a detailed survey of nurses, for 564 adult, general acute care hospitals from California, Florida, Pennsylvania, and New Jersey in 2006-2007. We used logistic regression models to examine whether patient (mortality and failure-to-rescue) and nurse (burnout, job satisfaction, and intent-to-leave) outcomes in Kaiser hospitals were better than in non-Kaiser hospitals. We then assessed whether differences in nursing explained outcomes differences between Kaiser and other hospitals. Finally, we examined whether Kaiser hospitals compared favorably with hospitals known for having excellent nurse work environments-Magnet hospitals. Patient and nurse outcomes in Kaiser hospitals were significantly better compared with non-Magnet hospitals. Kaiser hospitals had significantly better nurse work environments, staffing levels, and more nurses with bachelor's degrees. Differences in nursing explained a significant proportion of the Kaiser outcomes advantage. Kaiser hospital outcomes were comparable with Magnet hospitals, where better outcomes have been largely explained by differences in nursing. An important element in Kaiser's success is its investment in professional nursing, which may not be evident to systems seeking to achieve Kaiser's advantage. Our results suggest that a possible strategy for achieving outcomes like Kaiser may be for hospitals to consider Magnet designation, a proven and

  15. Force and Stress along Simulated Dissociation Pathways of Cucurbituril-Guest Systems.

    Science.gov (United States)

    Velez-Vega, Camilo; Gilson, Michael K

    2012-03-13

    The field of host-guest chemistry provides computationally tractable yet informative model systems for biomolecular recognition. We applied molecular dynamics simulations to study the forces and mechanical stresses associated with forced dissociation of aqueous cucurbituril-guest complexes with high binding affinities. First, the unbinding transitions were modeled with constant velocity pulling (steered dynamics) and a soft spring constant, to model atomic force microscopy (AFM) experiments. The computed length-force profiles yield rupture forces in good agreement with available measurements. We also used steered dynamics with high spring constants to generate paths characterized by a tight control over the specified pulling distance; these paths were then equilibrated via umbrella sampling simulations and used to compute time-averaged mechanical stresses along the dissociation pathways. The stress calculations proved to be informative regarding the key interactions determining the length-force profiles and rupture forces. In particular, the unbinding transition of one complex is found to be a stepwise process, which is initially dominated by electrostatic interactions between the guest's ammoniums and the host's carbonyl groups, and subsequently limited by the extraction of the guest's bulky bicyclooctane moiety; the latter step requires some bond stretching at the cucurbituril's extraction portal. Conversely, the dissociation of a second complex with a more slender guest is mainly driven by successive electrostatic interactions between the different guest's ammoniums and the host's carbonyl groups. The calculations also provide information on the origins of thermodynamic irreversibilities in these forced dissociation processes.

  16. Achievement report for fiscal 1998. Research and development of synergy ceramics (Research and development of anti-corrosion technologies for oil production system); 1998 nendo seika hokokusho. Shinaji ceramics no kenkyu kaihatsu (sekiyu seisan system fushoku boshi gijutsu kenkyu kaihatsu)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-03-01

    A computer simulation-aided designing technology is completed to help develop synergy ceramics which are complicated in phase constitution and material structure. A program, which simulates sintering and particle growth for multiple solid-state and solid-state/liquid-phase systems, has been built assuming the form of an integrated micro/nano level simulation technology based on the Monte Carlo method. The new program applies to systems consisting of more than three different phases, and deals in a uniform way with the designing of various textures formable by transfer of matters in solid-state particle growth, Ostwalt ripening, solid-state sintering, liquid-phase sintering, and additive reaction. The Monte Carlo method-assisted program is applied to systems based on AlN, Si{sub 3}N{sub 4}, and Al{sub 2}O{sub 3}, and a good result is achieved in each case. The molecular dynamic method is mainly used in atom level simulation for application to ZrO{sub 2}-Y{sub 2}O{sub 3} and Si-C-N, and a good result is achieved in each case. (NEDO)

  17. Report on achievements in fiscal 1998. Surveys on development of an at-home welfare device system to rationalize energy use; 1998 nendo energy shiyo gorika zaitaku fukushi kiki system kaihatsu chosa itaku kenkyu seika hokokusho

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-03-01

    This paper analyzes and puts into order the data surveyed and discussed on thirteen Welfare Techno-Houses (WTH) from a comprehensive viewpoint. It summarizes findings contributing to development and structuring of new at-home welfare device systems of effective energy utilization type. The paper first puts into order and discusses the survey and study items available for comparison and discussion, and the survey items with originality found in the surveys of the WTH, with which relatively large number of items were surveyed and studied among the thirteen locations nationwide. Next, the paper attempts comprehensive evaluation on the achievements thereof by the following items: (1) measurement and evaluation on energy consumption of different at-home welfare devices, (2) surveys and studies on energy demand evaluation inside and outside the residential houses arranged with considerations for elderly people according to the district characteristics, (3) evaluation on daily, weekly and annual changes in energy consumption in these houses, and (4) design and development of welfare systems of effective energy utilization type for these houses. Furthermore, the paper summarizes the general attributes of the WTHs in different districts, power consumption in these at-home welfare device systems in the WTH and energy consumption of the houses, in the forms available for comparison and discussion. Then, the paper summarizes the achievements of the present surveys and studies on the thirteen WTHs all over the country. (NEDO)

  18. Neonatal systemic inflammation and the risk of low scores on measures of reading and mathematics achievement at age 10 years among children born extremely preterm.

    Science.gov (United States)

    Leviton, Alan; Dammann, Olaf; Allred, Elizabeth N; Joseph, Robert M; Fichorova, Raina N; O'Shea, T Michael; Kuban, Karl C K

    2018-05-01

    Difficulties with reading and math occur more commonly among children born extremely preterm than among children born at term. Reasons for this are unclear. We measured the concentrations of 27 inflammatory-related and neurotrophic/angiogenic proteins (angio-neurotrophic proteins) in multiple blood specimens collected a week apart during the first postnatal month from 660 children born before the 28th week of gestation who at age 10 years had an IQ ≥ 70 and a Wechsler Individual Achievement Test 3rd edition (WIAT-III) assessment. We identified four groups of children, those who had a Z-score ≤ -1 on the Word Reading assessment only, on the Numerical Operations assessment only, on both of these assessments, and on neither, which served as the referent group. We then modeled the risk of each learning limitation associated with a top quartile concentration of each protein, and with high and lower concentrations of multiple proteins. The protein profile of low reading scores was confined to the third and fourth postnatal weeks when increased risks were associated with high concentrations of IL-8 and ICAM-1 in the presence of low concentrations of angio-neurotrophic proteins. The profile of low math scores was very similar, except it did not include ICAM-1. In contrast, the profile of low scores on both assessments was present in each of the first four postnatal weeks. The increased risks associated with high concentrations of TNF-α in the first two weeks and of IL-8 and ICAM-1 in the next two weeks were modulated down by high concentrations of angio-neurotrophic proteins. High concentrations of angio-neurotrophic proteins appear to reduce/moderate the risk of each learning limitation associated with systemic inflammation. The three categories of limitations have protein profiles with some similarities, and yet some differences, too. Copyright © 2018 ISDN. Published by Elsevier Ltd. All rights reserved.

  19. HEPEX - achievements and challenges!

    Science.gov (United States)

    Pappenberger, Florian; Ramos, Maria-Helena; Thielen, Jutta; Wood, Andy; Wang, Qj; Duan, Qingyun; Collischonn, Walter; Verkade, Jan; Voisin, Nathalie; Wetterhall, Fredrik; Vuillaume, Jean-Francois Emmanuel; Lucatero Villasenor, Diana; Cloke, Hannah L.; Schaake, John; van Andel, Schalk-Jan

    2014-05-01

    HEPEX is an international initiative bringing together hydrologists, meteorologists, researchers and end-users to develop advanced probabilistic hydrological forecast techniques for improved flood, drought and water management. HEPEX was launched in 2004 as an independent, cooperative international scientific activity. During the first meeting, the overarching goal was defined as: "to develop and test procedures to produce reliable hydrological ensemble forecasts, and to demonstrate their utility in decision making related to the water, environmental and emergency management sectors." The applications of hydrological ensemble predictions span across large spatio-temporal scales, ranging from short-term and localized predictions to global climate change and regional modeling. Within the HEPEX community, information is shared through its blog (www.hepex.org), meetings, testbeds and intercompaison experiments, as well as project reportings. Key questions of HEPEX are: * What adaptations are required for meteorological ensemble systems to be coupled with hydrological ensemble systems? * How should the existing hydrological ensemble prediction systems be modified to account for all sources of uncertainty within a forecast? * What is the best way for the user community to take advantage of ensemble forecasts and to make better decisions based on them? This year HEPEX celebrates its 10th year anniversary and this poster will present a review of the main operational and research achievements and challenges prepared by Hepex contributors on data assimilation, post-processing of hydrologic predictions, forecast verification, communication and use of probabilistic forecasts in decision-making. Additionally, we will present the most recent activities implemented by Hepex and illustrate how everyone can join the community and participate to the development of new approaches in hydrologic ensemble prediction.

  20. Reviewing nuclear power station achievement

    International Nuclear Information System (INIS)

    Howles, L.R.

    1976-01-01

    For measurement of nuclear power station achievement against original purchase the usual gross output figures are of little value since the term loosely covers many different definitions. An authentically designed output figure has been established which relates to net design output plus house load at full load. Based on these figures both cumulative and moving annual load factors are measured, the latter measuring the achievement over the last year, thus showing trends with time. Calculations have been carried out for all nuclear stations in the Western World with 150 MW(e) gross design output and above. From these are shown: moving annual load factor indicating relative station achievements for all the plants; cumulative load factors from which return of investment can be calculated; average moving annual load factors for the four types of system Magnox, PWR, HWR, and BWR; and a relative comparison of achievement by country in a few cases. (U.K.)

  1. Research and development project for large industrial technologies in fiscal 1989. Achievement report on research and development of manganese nodule mining system - Volume 1/6 (Edition for total system - experiment system); 1989 nendo mangan dankai saiko system no kenkyu kaihatsu seika hokokusho. 1/6. Total system (jikken system) hen

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1990-03-01

    With an objective to ensure non-ferrous metal resources such as nickel, cobalt, copper and manganese, and enhance the ocean development technologies, research and development has been performed on a technology to mine by using the fluid dredge system the manganese nodules existing in ocean bottoms as deep as 4,000 to 6,000 m. This paper summarizes the achievements in fiscal 1989. In the research and development of the total system, fabrication design was performed on a mining experimental vessel which takes the role of the base for the comprehensive ocean experiments. In addition, the comprehensive experiment implementation procedures were discussed, and such experimental simulation was carried out as operation of the vessel during handling and mining. Furthermore, discussions were given on the consistency of the ore lifting pipe and device with the handling system, and the system operating consistency, such as the handling method for the ore collecting machine. As part of the technical cooperation with France who is researching and developing independently a manganese nodule mining system, discussions were given on the compatibility of the mining experiment systems in Japan and France to execute the comprehensive experiments jointly. (NEDO)

  2. Report on achievements in fiscal 1998. Surveys on development of an at-home welfare device system to rationalize energy use (Shizuoka City); 1998 nendo energy shiyo gorika zaitaku fukushi kiki system kaihatsu chosa (Shizuoka) saiitaku kenkyu seika hokokusho

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-03-01

    In order to achieve rationalization in energy use, surveys and studies were performed on structuring new at-home welfare device systems of effective energy utilization type, based on structural characteristics of residential houses arranged with considerations for elderly people, and operation characteristics of at-home welfare device systems. For the 'evaluation of daily, weekly and annual changes in energy use at care-taking sites', measurements were performed on cumulative power during operation standby and momentary power under no load and load in eight care-taking devices such as a care-taking Gatch bed, a motor-driven lift-up cooking table and a home elevator installed in the WTH Shizuoka, by using a house energy measuring device. The measurements verified that large power is consumed during standby operation. In developing the 'at-home welfare device systems that utilize energy more effectively', a solar beam measuring device was used to measure over an extended period of time the power generation amount of a solar beam power generation system installed in the WTH Shizuoka. Evaluation was given on the system as an emergency power supply for an emergency event, and consideration was given on the effectiveness of the system in the Shizuoka district where daily sunlight irradiation lasts long. Development was made on an inexpensive walking training device, on which effectiveness as a waling training device was evaluated by using a position sensor and a force plate. (NEDO)

  3. Exciton dynamics in an energy up-converting solid state system based on diphenylanthracene doped with platinum octaethylporphyrin

    Energy Technology Data Exchange (ETDEWEB)

    Karpicz, R., E-mail: renata.karpicz@ftmc.lt [Center for Physical Sciences and Technology, Savanoriu Ave. 231, LT-02300 Vilnius (Lithuania); Puzinas, S.; Gulbinas, V. [Center for Physical Sciences and Technology, Savanoriu Ave. 231, LT-02300 Vilnius (Lithuania); Vakhnin, A. [Institute of Physics, National Academy of Sciences of Ukraine, 03028 Kyiv (Ukraine); Kadashchuk, A. [Institute of Physics, National Academy of Sciences of Ukraine, 03028 Kyiv (Ukraine); IMEC, Kapeldreef 75, B-3001 Heverlee-Leuven (Belgium); Rand, B.P. [IMEC, Kapeldreef 75, B-3001 Heverlee-Leuven (Belgium); Department of Electrical Engineering and the Andlinger Center for Energy and the Environment, Princeton University, Princeton, NJ 08544 (United States)

    2014-01-31

    Highlights: • We study exciton dynamics by ultrafast spectroscopies in DPA:PtOEP host–guest films. • Aggregation of PtOEP affects considerably the triplet energy transfer to DPA host. • No significant triplet loss due to TTA occurs within PtOEP aggregates. • Triplet energy transfer from PtOEP to DPA is slow and thermally activated process. • The ISC time in PtOEP is shorter than 100 fs. - Abstract: Photophysics of composite solid films based on 9,10-diphenylanthracene (DPA) doped with Pt(II)octaethylporphyrin (PtOEP) has been investigated by means of transient absorption and luminescence spectroscopy. The DPA:PtOEP host:guest system is a benchmark for incoherent energy up-conversion via triplet fusion in solution and we focus here on photophysical processes of this system in solid films. The triplet energy transfer from PtOEP to DPA takes place during tens of ns, featuring a thermally activated behavior. This implies that, before being transferred to the host, triplets migrate within PtOEP aggregates, defining a rate limiting step for the overall energy transfer to DPA. In contrast to other porphyrin-based sensitizers, no significant triplet–triplet annihilation was found to happen during triplet migration within PtOEP aggregates, implying that such a triplet loss mechanism does not universally apply to porphyrin-based organometallic complexes.

  4. Report on achievements of research and development of an automatic sewing system in fiscal 1985. Sewing preparation and processing technology; 1985 nendo jido hosei system no kenkyu kaihatsu seika hokokusho. Hosei junbi kako gijutsu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1986-03-01

    This paper describes the sewing preparation and processing technology, extracted from the achievement report for fiscal 1985 on developing an automatic sewing system. The cloth property evaluation technology was discussed by using the KES testing machine, and the composite transformation, large bending and composite surface property measuring device. Multiple regression analysis was made on cloth properties required for operation of each sewing process, and the summary of cloth properties required for the sewing devices was identified. A case study was performed on the data banking system on the sewing machine operating process as the object. For the cloth stabilization technology, seven kinds of temporary hardening agents were selected, and given the performance test. Literatures were investigated on tolerance for human body exposure to working environment pollution. Fabrication of the continuously operating temporary hardener processing device achieved the performance as designed. Discussions were given on temporary hardener flow rate and supply pressure, particle diameters and rotation speed of the rotating disk, particle properties and hardening performance, and work uniformity, where the performance of the continuous temporary hardening treatment was verified. High level correlation was derived between the relative handling difficulty and the cloth properties. With regard to the hardening standard, discussions are required also on the correlation with sewability. (NEDO)

  5. Report on achievements in fiscal 1999 on research and development of the Welfare Techno-system (Chuo Ward, Kobe); 1999 nendo Welfare Techno system kenkyu kaihatsu (Kobe-shi Chuo-ku) seika hokokusho

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-03-01

    Research and development has been performed on a help and welfare system to transmit and accumulate monitoring data by utilizing a computer system. This paper summarizes the achievements in fiscal 1999. In the research of transmission and management of information on help requiring persons, a server and its peripheral devices were modified to structure a system to measure body temperatures, pulses, and blood pressures, and transmit them to a central server. In the research on support for the visiting helps, a mobile system was developed, which has map information and scheduling function that shows distribution of help requiring persons. In the research of a simulation to link hospitals, medical organizations and homes, the LAN at health facilities for elderly people was structured, and so was a network for linking hospitals, medical organizations and homes (simulated). Investigations and discussions were performed on interface between body information (vital data) measuring instruments and personal computers. Developmental research was executed on private certification office servers and the certification software that consider security in the help systems. (NEDO)

  6. Report on achievements of research and development of an automatic sewing system in fiscal 1986. Cloth handling technology; 1986 nendo jido hosei system no kenkyu kaihatsu seika hokokusho. Kiji handling gijutsu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1987-03-01

    The Automatic Sewing System Technology Research Association was commissioned from the Agency of Industrial Science and Technology on the 'development of an automatic sewing system'. The association has performed the research and development by dividing the subject into such component technologies as a total system and sewing preparation and processing technology, a sewing and assembling technology, a cloth handling technology, and a system management and control technology. This paper reports the achievement of the research on the cloth handling technology. This technology may be divided into such component technologies as (1) the cloth holding technology, (2) the high-functional positioning technology, and (3) the soft cloth moving technology. For the technology (1), development was made on the principle models, such as the vertical holding and parallel holding type modules and the cloth operating type module, as well as on the principle model for an auxiliary equipment for holding cloth edges. For the technology (2), development was made on the handler, controller, and coordinated operation control and teaching system. Discussions were given on optimal device configuration, functions required in the devices, and evaluation methods, as the high-functional positioning technology for the sewing process and pressing process. Prototype devices were designed and fabricated. For the technology (3), prototype models of the improved version were fabricated for the stock module and confluence model, their functions and performances were confirmed, and problems and points requiring improvement were extracted for prototype fabrication. (NEDO)

  7. Report on achievements of research and development of an automatic sewing system in fiscal 1986. Cloth handling technology; 1986 nendo jido hosei system no kenkyu kaihatsu seika hokokusho. Kiji handling gijutsu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1987-03-01

    The Automatic Sewing System Technology Research Association was commissioned from the Agency of Industrial Science and Technology on the 'development of an automatic sewing system'. The association has performed the research and development by dividing the subject into such component technologies as a total system and sewing preparation and processing technology, a sewing and assembling technology, a cloth handling technology, and a system management and control technology. This paper reports the achievement of the research on the cloth handling technology. This technology may be divided into such component technologies as (1) the cloth holding technology, (2) the high-functional positioning technology, and (3) the soft cloth moving technology. For the technology (1), development was made on the principle models, such as the vertical holding and parallel holding type modules and the cloth operating type module, as well as on the principle model for an auxiliary equipment for holding cloth edges. For the technology (2), development was made on the handler, controller, and coordinated operation control and teaching system. Discussions were given on optimal device configuration, functions required in the devices, and evaluation methods, as the high-functional positioning technology for the sewing process and pressing process. Prototype devices were designed and fabricated. For the technology (3), prototype models of the improved version were fabricated for the stock module and confluence model, their functions and performances were confirmed, and problems and points requiring improvement were extracted for prototype fabrication. (NEDO)

  8. Achievement report for fiscal 1989 on the research and development of automatic sewing system. Production system for each apparel type; 1989 nendo jido hosei system no kenkyu kaihatsu seika hokokusho. Fukushubetsu seisan system

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1990-03-01

    A report is compiled about the above-named system being developed under the large-scale industrial technology development project. In the research of the production system for each apparel type, a test procedure is drawn up in preparation for the operation of the experimental plant. Since it is apparel manufacturers that will actually operate the experimental plant, the drafting work is committed to the apparel subcommittee. Materials prepared for the experimental operation based on the said test procedure include an experimental plant comprehensive operation procedure, evaluation items for the experimental plant comprehensive operation, experimental plant 2nd comprehensive operation procedure, simulation procedure for each apparel type, and a model wear 2nd patterning handbook. In the process of preparing these documents, discussion is made between the apparel subcommittee and the system subcommittee and thereby details are worked out. Deliberation of the experimental plant operation is also in progress by the hardware manufacturer concerned and, subsequently, a partial revision is introduced into the fundamental program on the experimental plant. (NEDO)

  9. The effects of geographic information system (GIS) technologies on students' attitudes, self-efficacy, and achievement in middle school science classrooms

    Science.gov (United States)

    Baker, Thomas Ray

    Since the publication of the National Science Education Standards , a concerted and evolving movement to make science classrooms more inquiry-oriented has been building. The proliferation of models of teaching and learning where questions and investigations drive learning, while not new are also not easy to plan, implement, or evaluate. In order to make the vision of the Standards come to fruition, educators are calling on the tools of technology to support and foster the shift to scientific inquiry or classroom research. The use of certain data analysis technologies have been suggested to be a particularly powerful ally in the struggle to extend classroom teaching and learning into the realm of problem-driven classroom inquiry. The use of a Geographic Information System (GIS), a technology allowing for the graphical representation of data with a geographic component seems to be one technology that can adequately bolster the dynamic and complex needs of the science classroom engaged in scientific inquiry. In this study, eighth grade Earth science students studying relative, local air quality indicators were divided in two groups; a treatment group that utilized GIS-supported scientific inquiry and a control group that used traditional mapping techniques to support their study. Student attitudes regarding science and technology were measured with a pre/post instrument across the study. Individual student efforts were summarily evaluated with a modified Kansas Science Performance Based Assessment rubric. During the two-week treatment, the students using the GIS-supported materials were found to show positive and significant improvements in science self-efficacy and attitudes toward technology. While female attitudes and self-efficacy were not found to change, males significantly improved on all affective factors. Students using GIS also performed significantly better than traditional mapping students on science process skills, specifically data analysis techniques

  10. Achieving Public Schools

    Science.gov (United States)

    Abowitz, Kathleen Knight

    2011-01-01

    Public schools are functionally provided through structural arrangements such as government funding, but public schools are achieved in substance, in part, through local governance. In this essay, Kathleen Knight Abowitz explains the bifocal nature of achieving public schools; that is, that schools are both subject to the unitary Public compact of…

  11. FFTF operations - 1980 - a year of achievement

    International Nuclear Information System (INIS)

    Newland, D.J.; Bliss, R.J.

    1981-01-01

    The year 1980 saw FFTF achieve initial criticality, proceed through an intense maintenance and system testing period, and achieve a remarkably successful two-day full power (400 MW) demonstration run. These achievements were preceded by two and one-half years of plant startup activity

  12. Report on achievements in fiscal 1999 on research and development of the Welfare Techno-system (Nishi Ward, Kobe); 1999 nendo Welfare Techno system kenkyu kaihatsu (Kobe-shi Nishi-ku) seika hokokusho

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-03-01

    Research and development has been performed on devices to enhance autonomy, safety and comfort for elderly and handicapped people in houses and homes. This paper summarizes the achievements in fiscal 1999. In developing wheelchairs to allow autonomy in meal taking and working at homes, a small upper arm holding device that can be installed on a wheelchair was fabricated on the trial basis according to the experience obtained in making the first prototype in the previous fiscal year, and clinical evaluation was given. In the research and development on a safe walk assisting appliance for elderly and handicapped people, development, improvement and trial fabrication were carried out on a caster in which the brake will not work during walking, but it works automatically in a sudden movement such as falling down. In developing an environment information transmitting system for elderly and handicapped people, a first prototype fabrication was performed on a system to detect sound of an alarm or vibration caused by knocking a door, and convey information to elderly and handicapped people by utilizing the communication services including the commercially available cellular phones. In the research on a welfare device support system for use in disaster and emergency, design and structuring were carried out on a nighttime electric power utilizing system having solar cells combined with storage batteries. Related data were measured. (NEDO)

  13. Achievement of Abraham Maslow's Needs Hierarchy Theory among Teachers: Implications for Human Resource Management in the Secondary School System in Rivers State

    Science.gov (United States)

    Adiele, E.E.; Abraham, Nath. M.

    2013-01-01

    The study investigated the achievement of Abraham Maslow's need hierarchy theory among secondary school teachers in Rivers State. A 25-item questionnaire was designed, validated and administered on a sample of 500 teachers drawn from 245 secondary schools in Rivers State. The result revealed that secondary school teachers indicated insignificant…

  14. Experimental Comparison of Gains in Achievable Information Rates from Probabilistic Shaping and Digital Backpropagation for DP-256QAM/1024QAM WDM Systems

    DEFF Research Database (Denmark)

    Porto da Silva, Edson; Yankov, Metodi Plamenov; Da Ros, Francesco

    2016-01-01

    Gains in achievable information rates from probabilistic shaping and digital backpropagation are compared for WDM transmission of 5 × 10 GBd DP-256QAM/1024QAM up to 1700 km of reach. The combination of both techniques its shown to provide gains of up to ∼0.5 bits/QAM symbol...

  15. Metrics, Dollars, and Systems Change: Learning from Washington State's Student Achievement Initiative to Design Effective Postsecondary Performance Funding Policies. A State Policy Brief

    Science.gov (United States)

    Jenkins, Davis; Shulock, Nancy

    2013-01-01

    The Student Achievement Initiative (SAI), adopted by the Washington State Board for Community and Technical Colleges in 2007, is one of a growing number of performance funding programs that have been dubbed "performance funding 2.0." Unlike previous performance funding models, the SAI rewards colleges for students' intermediate…

  16. Achieveing Organizational Excellence Through

    OpenAIRE

    Mehdi Abzari; Mohammadreza Dalvi

    2009-01-01

    AbstractToday, In order to create motivation and desirable behavior in employees, to obtain organizational goals,to increase human resources productivity and finally to achieve organizational excellence, top managers oforganizations apply new and effective strategies. One of these strategies to achieve organizational excellenceis creating desirable corporate culture. This research has been conducted to identify the path to reachorganizational excellence by creating corporate culture according...

  17. Achievement report on surveys and researches in the Sunshine Project in fiscal 1980. Surveys and researches on total energy systems; 1980 nendo total energy system ni kansuru chosa kenkyu seika hokokusho yoyaku

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1981-06-01

    Identifying the energy demand system as a total system covering from energy generation to the ultimate utilization, a quantitative and theoretical analysis method was developed in achieving selection and development of long-term strategy of Japan for 50 years from about 1975 to about 2025. Development was made on a supply estimation model by using the system dynamics method, that includes international fluctuation factors in primary energy supply structure and time-based relevant elements. Improvements were made in several occasions on the demand estimation model that includes movements of Japan's industrial structures and nation's needs for living, and fluctuation factors of population configuration. Development and improvement were made on the energy flow model to link the supply side with the demand side and analyze the energy flow. In addition, efforts were made on arranging data for inputting these models (data collection, putting them in order, and processing). These models are now in the phase of practical use, and three models have also been nearly completed. Quantitative analysis will be possible if arranging the input database is continued. (NEDO)

  18. Achievement report for fiscal 1999 on research and development of environment compatible next generation supersonic propulsion system; 1999 nendo kankyo tekigogata jisedai choonsoku suishin system no kenkyu kaihatsu seika hokokusho

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-09-01

    This paper describes the achievements in fiscal 1999 in development of an environment compatible next generation supersonic propulsion system. In order to reduce NOx emission, AI combustion control was discussed to have fabricated the backfire and autoignition detection device. The SiC photodiode was selected for flame detection, and a heat and pressure resistant fiberoptic probe was fabricated to detect flames in a high-temperature high-pressure combustor casing. These devices were combined to fabricate the backfire and autoignition detecting device, and the verification test was performed. For the purpose of application to an innovative heat resistant combustor liner, a silicon carbide material reinforced with silicon carbide fibers was selected. For continuous ceramic fiber as a reinforcing material, the Si-Zr-C-O system was selected, and the chemical gas-phase impregnation process effective to enhance the fiber/matrix interface characteristics as the matrix forming method was used together with the inexpensive precursor polymer impregnating and sintering process. Investigations were performed on the advanced control functions to reduce fuel consumption as the development of CO2 emission suppressing technology, and on the trends in discrete control. In addition, the optimal engine control logic and the specifications for discrete system constituting devices to be evaluated as the prototype in the future were established. (NEDO)

  19. Achievement report for fiscal 2000 on research and development of environment compatible next generation supersonic propulsion system; 2000 nendo kankyo tekigogata jisedai choonsoku suishin system no kenkyu kaihatsu seika hokokusho

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-03-01

    This paper describes the achievements in fiscal 2000 in development of an environment compatible next generation supersonic propulsion system. In order to reduce NOx emission, the AI combustion control technology was used to newly fabricate a pre-mixing and pre-evaporating tube model, whereas the backfire and autoignition detection device which has been fabricated on a trial basis was given a verification test in a high temperature and pressure site, whose condition is close to that in the actual combustor. A spectroscopic analyzer was used to sense flame light emission, and the operation was verified by using a model combustor. The basic discussion was given on a combustion control logic, whereas NOx reduction control was verified by using simulations. An Si-Zr-C-/Sic based CMC to be applied to an innovative heat resistant combustor liner was tested to have extracted items to be improved. In the CO2 emission suppression technology, logic design was made on a discrete control system, an engine performance optimization logic was developed, and its functions were verified. Detailed design was completed on a smart sensor to be tested in the HTCE engine operation. As the discussions on the engine system, verifications were given on the calculation of performance cycles during flight, estimation on NOx emission, the basic construction of the fan applied with metallic base composite materials, and the reasonability in the target of weight reduction. (NEDO)

  20. Fiscal 1999 achievement report. Research and technology of important regional technologies (Development of combustion control system technology for rationalizing energy use); 1999 nendo energy shiyo gorika nensho nado seigyo system gijutsu kaihatsu seika hokokusho

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-03-01

    For upgrading and optimizing combustion control systems, research and development is conducted for materializing SiC devices capable of high-temperature operation. In the development of basic technologies common to various types of SiC semiconductor devices, XeCl excimer laser annealing is applied to SiC implanted with Al ions, and low-damage ion implantation is studied. In the development of techniques for forming SiC single crystals into substrates, warpage of 20{mu} or less, surface coarseness of 5{mu}m or less, etc., are achieved in 1-inch and 2-inch wafers. In the development of SiC sensor technology, techniques of heteroepitaxial growth of 3C-SiC on Si substrates and of 6H-SiC on 6H-SiC wafers are established and an optical sensor is built experimentally. A high-temperature UV sensor, switching device for control, rectification device for control, etc., are built of nitrogen ion implanted 6H-SiC. In the effort to develop combustion control system technology, the principle of system operation of the combustion control method proposed under this project is verified. (NEDO)

  1. Report on achievements of research and development of an automatic sewing system in fiscal 1985. Cloth handling technology; 1985 nendo jido hosei system no kenkyu kaihatsu seika hokokusho. Kiji handling gijutsu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1986-03-01

    This paper describes the cloth handling technology, extracted from the achievement report for fiscal 1985 on developing an automatic sewing system. Development, experiment and evaluation were made on prototype cloth holding modules of vertical type and horizontal type. For a cloth operation type module, a principle model was developed. The cloth holding technology has a number of problems to be solved in the future, including systematization and application conditions of the holding devices. In improving the function of sewing process positioning, problems in devices were extracted, and functions to be added were put in order. Basics of the concept for the pressing process positioning was made clear, examples of the process layout drawings were prepared, and weights by processes were measured and put in order to discuss the holding force. The handler was given redundancy, and constructed with seven shafts to make it capable of avoiding obstacles, thereby having reduced the weight and size by 15%. The calculation operating time in a servo control module was shortened. The basic design was completed on the specifications for a coordinated operation control system. Discussions were given on functions and specifications of different constituting modules as a study on formation of the system to transport flexible cloths. (NEDO)

  2. Report on achievements of research and development of an automatic sewing system in fiscal 1986. Sewing preparation and processing technology; 1986 nendo jido hosei system no kenkyu kaihatsu seika hokokusho. Hosei junbi kako gijutsu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1987-03-01

    This paper describes the sewing preparation and processing technology from the achievement report for fiscal 1986 on developing an automatic sewing system. For the cloth property evaluation technology, such devices were used to measure different kinds of cloths and evaluate cloth properties related to sewing performance, as the KES testing machine, the measuring device for composite transformation, large transformation and bending, and composite surface properties, the cloth air permeability testing machine, and the thermal property measuring device. The system was verified with regard to data banking to confirm feasibility of the system to practical application. Among the cloth stabilizing technologies, discussions were given on age-based stability of cloth properties, repetitive transformation resistance, temperature, hardener deposition amount, and bending rigidity in cloths treated with temporary hardening agents. Discoloration, robustness and device damaging effect of cloths were also investigated. A partial and temporary hardening device was fabricated to make partial hardening possible. A continuous deflocculating device was also fabricated making deflocculation of temporarily hardened cloth possible. The deflocculation was discussed on the sewing process in relation with workability, and it was revealed that low-level hardening treatment is effective. It was verified that the handling is facilitated particularly in cloths that tend to curl. (NEDO)

  3. Experimental analysis of indoor air quality improvement achieved by using a Clean-Air Heat Pump (CAHP) air-cleaner in a ventilation system

    DEFF Research Database (Denmark)

    Sheng, Ying; Fang, Lei; Nie, Jinzhe

    2017-01-01

    This study investigated the air purification effect of a Clean-Air Heat Pump (CAHP) air-cleaner which combined a silica gel rotor with a heat pump to achieve air cleaning, heating and ventilation in buildings. The experiments were conducted in a field laboratory and compared a low outdoor air...... supply rate with CAHP air purification of recirculated air with three different outdoor air supply rates without recirculation or air cleaning. Sensory assessments of perceived air quality and chemical measurements of TVOC concentration were used to evaluate the air-cleaning performance of the CAHP....... The results of the experiment showed that the operation of the CAHP significantly improved the perceived air quality in a room polluted by both human bio-effluents and building materials. At the outdoor airflow rate of 2 L/s per person, the indoor air quality with CAHP was equivalent to what was achieved...

  4. The Impact of Course Delivery Systems on Student Achievement and Sense of Community: A Comparison of Learning Community versus Stand-Alone Classroom Settings in an Open-Enrollment Inner City Public Community College

    Science.gov (United States)

    Bandyopadhyay, Pamela

    2010-01-01

    This study examined the effects of two types of course delivery systems (learning community classroom environments versus stand-alone classroom environments) on the achievement of students who were simultaneously enrolled in remedial and college-level social science courses at an inner city open-enrollment public community college. This study was…

  5. Achievement report for fiscal 2000 on research and development of high level waste glass utilization system of CO2 emission suppression type; 2000 nendo CO2 haishutsu yokuseigata hai glass kodo riyo system no kenkyu kaihatsu seika hokokusho (kokaiyo)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-03-01

    With an objective to establish a waste glass recycling system of low cost and requiring less CO2 emission amount and energy consumption, research and development has been made on classification of waste glasses into particle composition that is required in regenerated commercial products. This paper summarizes the achievements in fiscal 2000. In the research of a waste glass reusing and supplying system designed by using LCA, discussions were given on items required in circulating and recycling waste glass resources, and quality control on raw materials and products. Evaluations of product quality control items were made on crystallized glass, sintered glasswool, automotive window glass, electric bulbs, fluorescent lamp glass, and quartz glass. Utilization tests were carried out for Mashiko porcelain china clay with an intention of expanding the application of waste glass, whereas the relationship between waste glass addition amount and optimal sintering temperature range was verified, disclosing that the limit of the waste glass addition is 10%. In the research on multi-functional hybrid materials, discussions were given on light-weight tiles and water permeating blocks with regard to the manufacturing technology, facility specifications, product quality, effects of the functions, and durability. (NEDO)

  6. Achievement report for fiscal 2000. Phase II research and development task-5 for hydrogen utilizing international clean energy system technology (WE-NET) (Development of hydrogen fueled automobile system); 2000 nendo suiso riyo kokusai clean energy system gijutsu (WE-NET) dai 2 ki kenkyu kaihatsu. Task 5. Suiso jidosha system no kaihatsu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-03-01

    This paper describes the achievements in fiscal 2000 from the WE-NET Phase II for Task-5, the development of a hydrogen fueled automobile system. For a fast filling method using a hydrogen absorbing alloy as the fuel tank, a rare earth system, the Laves system, and a body-centered cubic system were selected to discuss filling time when the plate-fin system tank and the divided system tank are used. Either system was found capable of filling 80% of the effective hydrogen absorbing amount within 10 minutes, having achieved the target. Guidelines were obtained for the design aiding method by using the cooling water flow rates, temperatures, and simulations. In the safety assessment, even the spontaneously combusting alloy of Category 1 in the Fire Fighting Law did not cause ignition even if the tank was damaged and the alloy was discharged in the dropping/falling weight tests. It was inferred that the ignition temperature is not reached because of the self-cooling made when hydrogen is discharged from the alloy. In the fire resistance test, the tank temperature was found not to rise as long as hydrogen is discharged from the alloy. Since the temperature rise and damage could occur if the discharge has been finished completely, discussions are required on materials and the soluble plug. Deformation may occur in the initial stage of the hydrogen absorbing and discharging cycles, but it would not occur after 5,000 cycles. (NEDO)

  7. U.S. electric power sector transitions required to achieve 80% reductions in economy-wide greenhouse gas emissions: Results based on a state-level model of the U.S. energy system

    Energy Technology Data Exchange (ETDEWEB)

    Iyer, Gokul C.; Clarke, Leon E.; Edmonds, James A.; Kyle, Gordon P.; Ledna, Catherine M.; McJeon, Haewon C.; Wise, M. A.

    2017-05-01

    The United States has articulated a deep decarbonization strategy for achieving a reduction in economy-wide greenhouse gas (GHG) emissions of 80% below 2005 levels by 2050. Achieving such deep emissions reductions will entail a major transformation of the energy system and of the electric power sector in particular. , This study uses a detailed state-level model of the U.S. energy system embedded within a global integrated assessment model (GCAM-USA) to demonstrate pathways for the evolution of the U.S. electric power sector that achieve 80% economy-wide reductions in GHG emissions by 2050. The pathways presented in this report are based on feedback received during a workshop of experts organized by the U.S. Department of Energy’s Office of Energy Policy and Systems Analysis. Our analysis demonstrates that achieving deep decarbonization by 2050 will require substantial decarbonization of the electric power sector resulting in an increase in the deployment of zero-carbon and low-carbon technologies such as renewables and carbon capture utilization and storage. The present results also show that the degree to which the electric power sector will need to decarbonize and low-carbon technologies will need to deploy depends on the nature of technological advances in the energy sector, the ability of end-use sectors to electrify and level of electricity demand.

  8. IEEE Computer Society/Software Engineering Institute Watts S. Humphrey Software Process Achievement Award 2016: Raytheon Integrated Defense Systems Design for Six Sigma Team

    Science.gov (United States)

    2017-04-01

    worldwide • $23 billion in sales for 2015 Raytheon Integrated Defense Systems (IDS) is one of five businesses within Raytheon Company and is headquartered...Raytheon Integrated Defense Systems DFSS team has developed and implemented numerous leading-edge improvement and optimization methodologies resulting in...our software systems . In this section, we explain the first methodology, the application of statistical test optimization (STO) using Design of

  9. Fiscal 1998 New Sunshine Program achievement report. Development for practical application of photovoltaic system - Research and development of photovoltaic system evaluation technology (Research and development of system evaluation technology - Photovoltaic system data book, separate volume); 1998 nendo taiyoko hatsuden system jitsuyoka gijutsu kaihatsu seika hokokusho. Taiyoko hatsuden system hyoka gijutsu no kenkyu kaihatsu (system hyoka gijutsu no kenkyu kaihatsu bessatsu (taiyoko hatsuden system data shu))

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-03-01

    In the research and development of photovoltaic power generation system evaluation technology, great progress has been achieved in performance improvement and cost reduction as far as constituent devices such as power modules and inverters are concerned. In the designing of systems, however, quantitative elucidation of loss and power reduction factors remains insufficient. Under the circumstances, several types of photovoltaic power generation systems expected to be put to practical application in the future are taken up, test facilities are constructed which simulate them, and data are collected. The thus-collected data are utilized for research and development of evaluation techniques necessary for the improvement of photovoltaic system efficiency, such as design parameter quantification, databasing and utilization thereof, and simulation technologies, for the establishment of technologies for optimum designs and optimum operations. The data book accommodates data, arranged in an easy-to-use fashion, collected about verification test facility (interconnected systems, independent systems, and water pump systems) operation, weather conditions, and residential photovoltaic power generation systems. (NEDO)

  10. NCLB: Achievement Robin Hood?

    Science.gov (United States)

    Bracey, Gerald W.

    2008-01-01

    In his "Wall Street Journal" op-ed on the 25th of anniversary of "A Nation At Risk", former assistant secretary of education Chester E. Finn Jr. applauded the report for turning U.S. education away from equality and toward achievement. It was not surprising, then, that in mid-2008, Finn arranged a conference to examine the…

  11. Reducing the Achievement Gap.

    Science.gov (United States)

    McCombs, Barbara L.

    2000-01-01

    Reviews the College Board's report, "Reaching the Top," which addresses educational underrepresentation of high-achieving minority students, examining how social sciences, psychology, and education research contribute to an understanding of the feasibility of the report's recommendations and noting implications of these recommendations…

  12. Explorations in achievement motivation

    Science.gov (United States)

    Helmreich, Robert L.

    1982-01-01

    Recent research on the nature of achievement motivation is reviewed. A three-factor model of intrinsic motives is presented and related to various criteria of performance, job satisfaction and leisure activities. The relationships between intrinsic and extrinsic motives are discussed. Needed areas for future research are described.

  13. Schooling and Social Achievement.

    Science.gov (United States)

    Kim, Byong-sung; And Others

    Until the 1960s schooling in Korea was looked upon quite favorably as a means of achieving equal social and economic opportunities. In the 1970s, however, many began to raise the question of whether the expansion of educational opportunities really did reduce social inequalities. This report discusses research that analyzes available evidence…

  14. Correlates of Achievement Motivation.

    Science.gov (United States)

    Whiteside, Marilyn

    1978-01-01

    Undergraduates given a self-concept scale, a sentence completion exercise, and story cues related to academic achievement generally expressed positive attitudes toward success; but students of both sexes with high self-esteem tended to associate success with a male, and those with lower self-esteem attributed success to a female. (Author)

  15. Achieving Quality Integrated Education.

    Science.gov (United States)

    Hawley, Willis D.; Rosenholtz, Susan J.

    While desegregation is neither a necessary nor a sufficient condition for ensuring either equity or quality education for minorities, the evidence is convincing that it is "educationally more difficult" to improve student achievement in segregated schools. Desegregation offers the opportunity to enhance the quality of education, particularly when…

  16. An Analysis of the Effect of a Cyber Home Learning System on Korean Secondary School Students' English Language Achievement and Attitude

    Science.gov (United States)

    Shin, Ji Hye; Albers, Peggy

    2015-01-01

    This study examined the effectiveness of a Cyber Home Learning System (CHLS), an online learning system currently being employed in South Korea to improve the access and quality of public education as well as to reduce private tutoring expenditures. The quasi-experimental research design used experiment and survey methods to learn about the impact…

  17. Recent progresses and achievements in photovoltaic-phase change material technology: A review with special treatment on photovoltaic thermal-phase change material systems

    International Nuclear Information System (INIS)

    Islam, M.M.; Pandey, A.K.; Hasanuzzaman, M.; Rahim, N.A.

    2016-01-01

    Highlights: • Broad summary of phase change materials based cooling for photovoltaic modules. • Compendium on phase change materials that are mostly used in photovoltaic systems. • Extension of heat availability period by 75–100% with phase change material. • Heat storage potential improves by 33–50% more with phase change material. • Future trend and move in photovoltaic thermal research. - Abstract: This communication lays out an appraisal on the recent works of phase change materials based thermal management techniques for photovoltaic systems with special focus on the so called photovoltaic thermal-phase change material system. Attempt has also been made to draw wide-ranging classification of both photovoltaic and photovoltaic thermal systems and their conventional cooling or heat harvesting methods developed so far so that feasible phase change materials application area in these systems can be pointed out. In addition, a brief literature on phase change materials with particular focus on their solar application has also been presented. Overview of the researches and studies establish that using phase change materials for photovoltaic thermal control is technically viable if some issues like thermal conductivity or phase stability are properly addressed. The photovoltaic thermal-phase change material systems are found to offer 33% (maximum 50%) more heat storage potential than the conventional photovoltaic-thermal water system and that with 75–100% extended heat availability period and around 9% escalation in output. Reduction in temperature attained with photovoltaic thermal-phase change material system is better than that with regular photovoltaic-thermal water system, too. Studies also show the potential of another emerging technology of photovoltaic thermal-microencapsulated phase change material system that makes use of microencapsulated phase change materials in thermal regulation. Future focus areas on photovoltaic thermal-phase change

  18. Achievement report for fiscal 1990 on the research and development of automatic sewing system. High-tech assemble subsystem; 1990 nendo jido hosei system no kenkyu kaihatsu seika hokokusho. High tech assemble system

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1991-03-01

    In a comprehensive operational test conducted for the automatic overlapping seam sewing system being studied under the above-named large-scale industrial technology development project, it is confirmed that it attains the target levels in product qualities such as accuracy and in productivity and flexibility. It is further confirmed in an experimental plant that the system fully discharges its duty. In the research and development of the ventral coordination control type assemble sewing technology, modification and research and development of the hardware and software, system construction, and operational adjustment are accomplished. In the comprehensive study of operation, data are collected for the evaluation of functioning during system operation, operational reliability, compatibility with multiple-product/small-amount production, sewed product quality stability, etc. In the study of systematization for the experimental plant, conditions for interlocking and sequence are defined, which are improved while system operation proceeds. Furthermore, studies are conducted about 3-dimensional sewing technologies and retrofitted sewing machines. (NEDO)

  19. Improving the Legal System Regime Specific to Biosphere Reservation of Danube Delta achieved by the Law no. 136 of July 5, 2011

    Directory of Open Access Journals (Sweden)

    Tache Bocaniala

    2012-08-01

    Full Text Available In order to establish a regime of protection and conservation of the Danube Delta, but alsoto achieve international commitments of Romania, it was developed and adopted by the Parliament aspecial law, Law no. 82/1993, establishing the Biosphere Reservation of Danube Delta. Theestablished rules had in mind mainly the preservation and protection of the existing natural heritage,promoting the sustainable use of resources resulting from natural ecosystems of the reserve andreconstruction of areas damaged by the impact of human activities. Although repeatedly amended andsupplemented, this regulatory framework has always been overwhelmed by economic and socialdevelopment of the area, requiring practically a major reform that was carried out by Law no 136 ofJuly 5, 2011.

  20. Study of methylation sites and factors in contaminated aquatic systems in the Amazon using an optimized radiochemical technique. Highlights and achievements

    International Nuclear Information System (INIS)

    Davee Guimaraes, Jean Remy

    2002-01-01

    Full text: Highlights and achievements: We confirmed that high methylation potentials (up to 22%) are found in roots of Paspalum repens and other floating macrophyte species such as Eichhomia crassipes and Ludwigia helmynthoryza during both phases of the hydrological cycle, with a tendency for higher values in the wet season, confirming findings of previous studies, and a strong intra and interlake variation. Hg methylation in macrophyte roots is carried out mainly in the root-associated periphyton a complex and variable assemblage of benthic microalgae, fungi, bacteria and organic and inorganic detritus. However, no significant correlation was found in the first campaign between Hg methylation in samples of Paspalum sp. roots and the amount of periphyton in these samples. We also verified that total plankton and phytoplankton are sites of a low 203 Hg; Basic infrastructure problems caused partial loss of samples in one of the campaigns. (author)

  1. The effectiveness of Light Rail transit in achieving regional CO2 emissions targets is linked to building energy use: insights from system dynamics modeling

    Data.gov (United States)

    U.S. Environmental Protection Agency — Dataset is comprised of a series of journal publications (in pdf form) that use system dynamics modeling to analyze the interactions among transportation, land use,...

  2. Achievement report for fiscal 1998. Research and development of a multi-plant maintenance system (the first year); 1998 nendo seika hokokusho. Odanteki maintenance gijutsu no kenkyu kaihatsu (dai 1 nendo)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-03-01

    This research and development is intended to structure a network centering around a center having systematized high-level maintenance technology, by utilizing the technological infrastructure having been built in local areas, together with element technologies possessed by national and private research institutes, universities and colleges. It is also purposed to establish a new industrial system for maintenance to realize high reliability, high operation rate and low cost in plants in certain areas. The present fiscal year had the following achievements: research and development of a maintenance system, a maintenance model, a maintenance vehicle, damage estimating technology for stationary parts such as piping, an anomaly diagnostic system using acoustic emission, an anomaly diagnostic system using wear particles in lubricant, an anti-wear material using surface modification, a lubrication control system, and an anomaly diagnostic system using ultrasonic waves. The research and development executing organization was divided into four groups for the maintenance system, maintenance model, maintenance vehicle, and maintenance tool. All groups have achieved the initial plans satisfactorily. (NEDO)

  3. Learning Motivation and Achievements

    Institute of Scientific and Technical Information of China (English)

    冯泽野

    2016-01-01

    It is known to all that motivation is one of the most important elements in EFL learning.This study analyzes the type of English learning motivations and learning achievements within non-English majors’ students (Bilingual program in Highway School and Architecture) in Chang’an University, who has been considered English as the foreign language. This thesis intends to put forward certain strategies in promoting foreign language teaching.

  4. Achieving maximum baryon densities

    International Nuclear Information System (INIS)

    Gyulassy, M.

    1984-01-01

    In continuing work on nuclear stopping power in the energy range E/sub lab/ approx. 10 GeV/nucleon, calculations were made of the energy and baryon densities that could be achieved in uranium-uranium collisions. Results are shown. The energy density reached could exceed 2 GeV/fm 3 and baryon densities could reach as high as ten times normal nuclear densities

  5. Fiscal 1998 New Sunshine Program achievement report. Development for practical application of photovoltaic system - Research and development of photovoltaic system evaluation technology (Research, development, and survey of crystalline solar cell evaluation system); 1998 nendo taiyoko hatsuden system jitsuyoka gijutsu kaihatsu seika hokokusho. Taiyoko hatsuden system hyoka gijutsu no kenkyu kaihatsu (kesshokei taiyo denchi hyoka system no kenkyu kaihatsu chosa)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-03-01

    In the basic study of ultrahigh-efficiency cells, the technology of ribbon crystal growing is again attracting attention for shortage of Si material supply. The new technology and problems to solve for cost reduction for it are discussed. Concerning the bulk type crystalline Si which is a core material, recent trends are mentioned involving studies of basic substrate properties such as the photoabsorption coefficient and crystal defects for achieving higher efficiency, development of gettering and surface passivation technologies, enhancement of processing speeds, radiation concentration behavior, etc. Newly obtained findings about photodegradation are mentioned, and some remedial measures are described. Recent reports on the application of porous Si to solar cells are compiled. In connection with the development of low-cost quantity-production process technologies, a remarkable progress recently marked by polycrystalline Si solar cells is described. Furthermore, it is stated that new process technologies will be required in the fields of material refining, substrate manufacturing, and cell fabrication. A proposition is presented aiming at developing cell modules compatible with application systems and practicalizing modules that may be integrated with roofing materials. Reference is also made to surveys overseas. (NEDO)

  6. Fiscal 2000 achievement report on the venture business assisting type regional consortium - Core industry creation type. Thermoelectric energy recovery system for automobile; 2000 nendo chiiki consortium kenkyu kaihatsu jigyo seika hokokusho. Jidoshayo netsuden energy kaishu system

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-03-01

    The project aims to develop a system for recovering heat from the thermal energy of automobile exhaust in the form of electric energy. Skutterudite based thermoelectric materials for high temperature use and existing thermoelectric materials for low/middle temperature use were improved in performance, and a dimensionless thermoelectric performance index of ZT=1 was attained. Advanced processes were applied for improvement on the performance of existing thermoelectric materials. In the effort to develop technologies for the mass production of thermoelectric materials for high temperature use, a material manufacturing process was established for manufacturing materials excellent in thermoelectric and mechanical properties using a method for mass-producing sinterable materials by gas atomization and a large discharge plasma sintering process capable of treating large specimens. In the effort to improve automobile power generation modules in performance and to establish element technologies for their manufacture, technologies were developed involving thermoelectric materials and electrodes, bonding of different thermoelectric materials, bonding of heat conducting electrical insulators and electrodes, and high efficiency segment type power generation modules. A high performance automobile exhaust gas heat exchanger was developed. A Co-Sb based thermoelectric module and a Bi-Te based module were combined and the package was tested aboard automobiles, when a maximum power output of 83W was achieved. It is necessary to review module arrangement. (NEDO)

  7. A compact control system to achieve stable voltage and low jitter trigger for repetitive intense electron-beam accelerator based on resonant charging

    Science.gov (United States)

    Qiu, Yongfeng; Liu, Jinliang; Yang, Jianhua; Cheng, Xinbing; Yang, Xiao

    2017-08-01

    A compact control system based on Delphi and Field Programmable Gate Array(FPGA) is developed for a repetitive intense electron-beam accelerator(IEBA), whose output power is 10GW and pulse duration is 160ns. The system uses both hardware and software solutions. It comprises a host computer, a communication module and a main control unit. A device independent applications programming interface, devised using Delphi, is installed on the host computer. Stability theory of voltage in repetitive mode is analyzed and a detailed overview of the hardware and software configuration is presented. High voltage experiment showed that the control system fulfilled the requests of remote operation and data-acquisition. The control system based on a time-sequence control method is used to keep constant of the voltage of the primary capacitor in every shot, which ensured the stable and reliable operation of the electron beam accelerator in the repetitive mode during the experiment. Compared with the former control system based on Labview and PIC micro-controller developed in our laboratory, the present one is more compact, and with higher precision in the time dimension. It is particularly useful for automatic control of IEBA in the high power microwave effects research experiments where pulse-to-pulse reproducibility is required.

  8. Fiscal 1999 achievement report on research and development project on intellectual infrastructure creation and utilization technologies. Development of efficient protein expression system (Development of efficient protein expression system utilizing protein folding mechanism of hyperthermophilic bacteria); 1999 nendo kokoritsu tanpakushitsu hatsugen system no kaihatsu seika hokokusho. Chokonetsukin no tanpakushitsu oritatami kiko wo riyoshita kokoritsu tanpakushitsu hatsugen system no kaihatsu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-03-01

    Efforts were exerted to achieve efficient expression of proteins of hyperthermophilic bacteria, hyperthermophilic archaeabacteria in particular, using a heterogene expression system in which Escherichia coli was the host. In an effort to search for genes related to protein folding and to elucidate the mechanism of folding, chaperonin and prefoldin subunit genes, out of various factors participating in protein folding in hyperthermophilic archaeabacteria, were cloned, and expressed in Escherichia coli. As a system for analyzing protein folding reaction, an experimental system was established on a substrate comprising isopropyl malate dehydrogenase, citrate synthase, glucose dehydrogenase, and a green fluorescent protein. Studies were further conducted to elucidate the mechanism of expression of enzyme genes in Escherichia coli for the establishment of a mass production method for useful enzymes. Also carried out was the research and development of an element technology evaluation system involving protein expression. (NEDO)

  9. Unification of Theoretical Models of Academic Self-Concept/Achievement Relations: Reunification of East and West German School Systems after the Fall of the Berlin Wall

    Science.gov (United States)

    Marsh, Herbert W.; Koller, Olaf

    2004-01-01

    Longitudinal data (five waves) from large cohorts of 7th grade students in East Germany ("n"=2,119) and West Germany ("n"=1,928) were collected from the start of the reunification of the school systems following the fall of the Berlin Wall. Here we integrate the two major theoretical models of relations between academic…

  10. A Study on the Effect of the Macmillan Tutorial System on the Reading Achievement of Selected First Graders in Nash County.

    Science.gov (United States)

    Smith, Ruth Suessmuth

    The purpose of this study was to determine the effect of the Macmillan Tutorial System when used as a supplement to regular classroom instruction in beginning reading. The experimental subjects were first grade children who ranked in the lower third of the distribution scores on the Macmillan Reading Readiness Test or who, in the opinion of their…

  11. The Tab: How Connecticut Can Fix Its Dysfunctional Education Spending System to Reward Success, Incentivize Choice and Boost Student Achievement. A ConnCAN/Public Impact Research Report

    Science.gov (United States)

    Hassel, Bryan C.; Doyle, Daniela

    2009-01-01

    Thirty years ago, the Connecticut Supreme Court forced our state to take stock of its system for funding schools. Our poorest towns had thousands of dollars less per child to spend. Today, our poorest districts spend roughly the same as our richest, but Connecticut's poor children still score far below their wealthy peers. Our school finance…

  12. The effects of laying hen housing systems on egg safety and quality. In: Achieving sustainable production of eggs, Vol 1: Safety and Quality

    Science.gov (United States)

    Transitions in laying hen management and housing systems have constantly occurred throughout the history of commercial egg production. Around the world, there has been a rapid shift in hen housing requirements since the turn of the current century. In most cases, the changes in hen housing require...

  13. Student Progress to Graduation in New York City High Schools. Part II: Student Achievement as "Stock" and "Flow"--Reimagining Early Warning Systems for At-Risk Students

    Science.gov (United States)

    Fairchild, Susan; Carrino, Gerard; Gunton, Brad; Soderquist, Chris; Hsiao, Andrew; Donohue, Beverly; Farrell, Timothy

    2012-01-01

    New Visions for Public Schools has leveraged student-level data to help schools identify at-risk students, designed metrics to capture student progress toward graduation, developed data tools and reports that visualize student progress at different levels of aggregation for different audiences, and implemented real-time data systems for educators.…

  14. Fiscal 2000 achievement report. Research on machine tool not necessitating hydraulic system; 2000 nendo yuatsu resu kosaku kikai no kenkyu seika hokokusho

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-03-01

    From the viewpoint that the manufacturing process, expendable items, and recycling should all be taken into consideration when machine tool energy consumption is the matter to discuss, it is concluded that the most important policy to follow in the effort to enhance energy conservation is to enable the tool to operate without hydraulic systems. For the realization of a general-purpose machine tool (lathe) to operate free of hydraulic systems, efforts are exerted to develop element technologies, tool rests, tail stocks, and chuck drives usable for the construction of a practical hydraulic system-free machine tool. In fiscal 2000, comprehensive evaluation of experimental machine tools continued, problems to solve for practical application were put together for the fabrication of improved units, and the improved units and an improved control method were integrated into a prototype of practical machine tools. The prototype was exhibited at Japan International Machine Tool Fair (JIMTOF) as a hydraulic system-free NC (numerically controlled) lathe Type LB300, and won a high valuation. The prototype was then tested for basic performance and for possibility of improvement, and problems to be solved before commercialization were isolated. (NEDO)

  15. Procurement and Supply Management System for MDR-TB in Nigeria: Are the Early Warning Targets for Drug Stock Outs and Over Stock of Drugs Being Achieved?

    Science.gov (United States)

    Jatau, Bolajoko; Avong, Yohanna; Ogundahunsi, Olumide; Shah, Safieh; Tayler Smith, Katherine; Van den Bergh, Rafael; Zachariah, Rony; van Griensven, Johan; Ekong, Ernest; Dakum, Patrick

    2015-01-01

    The World Health Organisation (WHO) introduced the twelve early warning indicators for monitoring and evaluating drug Procurement and Supply management (PSM) systems, intended to prevent drug stock-outs and overstocking. Nigeria--one of the high Multi Drug Resistant Tuberculosis (MDR-TB) burden countries, scaled-up treatment in 2012 with the concurrent implementation of a PSM system. We evaluated how well this system functioned using the WHO indicators, including all seven MDR-TB treatment centres in the country that were functional throughout 2013. The quantity of MDR-TB drugs ordered for 2013 matched the annual forecast and all central orders placed during the year were delivered in full and on time. Drug consumption was 81%-106% of the quantity allocated for routine consumption. Timely submission of complete inventory reports ranged from 86-100%, late submissions being 5-15 days late. Forty to 71% of treatment centres placed a drug order when stock was below the minimum level of three months. The proportion of drug orders received at the treatment centres in full and on time ranged from 29-80%, late orders being 1-19 days late. The PSM was found to be performing well in terms of forecasting and procurement of MDR-TB drugs, but there were shortcomings in drug distribution, reporting at treatment centre level and in drug order placements. Despite these gaps, there were no stock outs. These findings indicate that where it matters most, namely ensuring that no drug stock outs affect patient management, the PSM system is effective. Addressing the observed shortcomings will help to strengthen the existing PSM system in anticipation of a growing MDR-TB case burden in the country.

  16. Outstanding engineering achievement

    International Nuclear Information System (INIS)

    Anon.

    1984-01-01

    The annual award of the South African Institution of Civil Engineers for 'The Most Outstanding Civil Engineering Achievement of 1982' was made to Escom for the Koeberg Nuclear Power Station. In the site selection a compromise had to be made between an area remote from habitation, and an area relatively close to the need for power, sources of construction materials, transportation, operational staff and large quantities of cooling water. In the construction of Koeberg the safety of the workers and the public was regarded with the utmost concern

  17. Fiscal 1999 achievement report on development of wide-area energy utilization network system. Research on energy system design technology (Research on Eco-Energy City systematization); Eco ene toshi no system ka kenkyu 1999 nendo seika hokokusho

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-05-01

    Efforts are being exerted to develop systems for effectively utilizing various kinds of waste heat in presence in cities and their neighborhood. In fiscal 1999, investigations were conducted into cases of low temperature waste heat utilization at 16 locations in Japan and into trends of heat utilization in five European countries, with a visit paid to European District Heating Association. There are 128 district heat supplying sites in service in Japan, of which 25 handles low temperature waste heat. As for their types of utilization, 12 are of the temperature difference energy utilization type while 13 are of the heat recovery type. When it comes to the system details, the importance of proper selection of structures and materials for heat accumulating systems and heat exchangers on the secondary side should be emphasized although it is the heat pump that assumes the key role. In Europe, indications are that district systems are developing into wide-area networks and that they are growing increasingly marketable. In the northern and eastern parts of Europe, 30-70% of demand for heat is met by district heating. Waste heat from power generation is the heat source, and this occupies 30-80% of the whole. Thanks to the introduction of the environmental tax, in addition, environments are now complete under which recoverable energy utilization will enjoy an advantageous position. (NEDO)

  18. The impact of the EU car CO_2 regulation on the energy system and the role of electro-mobility to achieve transport decarbonisation

    International Nuclear Information System (INIS)

    Thiel, Christian; Nijs, Wouter; Simoes, Sofia; Schmidt, Johannes; Zyl, Arnold van; Schmid, Erwin

    2016-01-01

    We analyse the impact of the current and an alternative stricter EU CO_2 car legislation on transport related CO_2 emissions, on the uptake of electric vehicles (EV), on the reduction of oil consumption, and on total energy system costs beyond 2020. We apply a TIMES based energy system model for Europe. Results for 2030 show that a stricter target of 70 g CO_2/km for cars could reduce total transport CO_2 emissions by 5% and oil dependence by more than 2% compared to the current legislation. The stricter regulatory CO_2 car target is met by a deployment of more efficient internal combustion engine cars and higher shares of EV Total system costs increase by less than 1%. The analysis indicates that EV deployment and the decarbonisation of the power system including higher shares of variable renewables can be synergistic. Our sensitivity analysis shows that the deployment of EV would sharply increase between 2020 and 2030 at learning rates above 12.5%, reaching shares above 30% in 2030. Finally, the study highlights that, besides legislating cars, policies for other transport sectors and modes are needed to curb transport related CO_2 emission growth by 2030. - Highlights: •Car CO_2 regulation effective policy to reduce transport CO_2 emissions. •Learning rate above 12.5% can lead to sharp increase in electric vehicle deployment. •Electric vehicles can foster the deployment of variable renewable electricity. •Policies for other modes needed to curb transport CO_2 growth.

  19. Achieving a Patient-Centered, Value-Based System of Diabetes Care in the United States: Report on a National Stakeholder Summit

    OpenAIRE

    Nash, David B.; Skoufalos, Alexis; Harris, Dennis

    2018-01-01

    Abstract Chronic instability in the health care environment has raised concerns among providers and patients, especially those who treat and cope with chronic conditions. Changes to existing health care laws are unlikely to alter what have become the primary goals of the US health care system: cost-effectiveness and patient-centricity. To that end, it is vital that patient and physician voices be incorporated in policy decisions and, importantly, that access to care and patient-reported outco...

  20. Achievement in Physics

    Science.gov (United States)

    1999-03-01

    Naomi Moran, a student at the Arnewood School, New Milton, Hampshire was the first recipient of the `Achievement in Physics' prize awarded by the South Central Branch of The Institute of Physics. Naomi received an award certificate and cheque for £100 from Dr Ruth Fenn, Chairman of the Branch, at the annual Christmas lecture held at the University of Surrey in December. She is pictured with Dr Fenn and Steve Beith, physics teacher at the Arnewood School.  Photo Figure 1. Naomi Moran receiving her award (photograph courtesy of Peter Milford). The award is intended to celebrate personal achievement in physics at any level at age 16-17 and is not restricted to those who gain the highest academic results. Schools across the county were invited to nominate suitable candidates; Naomi's nomination by the school's deputy head of science impressed the judges because of her ability to grasp the most difficult parts of the subject quickly, in addition to the fact that she took her AS-level science in year 11 when she was only 16. She is currently studying A-level physics, chemistry and mathematics and hopes to continue her studies at university later this year.

  1. Molecular dynamics study on the structure I clathrate-hydrate of methane + ethane mixture

    International Nuclear Information System (INIS)

    Erfan-Niya, Hamid; Modarress, Hamid; Zaminpayma, Esmaeil

    2011-01-01

    Molecular dynamics (MD) simulations are used to study the structure I stability of methane + ethane clathrate-hydrates at temperatures 273, 275 and 277 K. NVT- and NPT-ensembles are utilized in MD simulation, and each consists of 3 x 3 x 3 replica unit cells containing 46 water molecules which are considered as the host molecules and up to eight methane + ethane molecules considered as the guest molecules. In MD simulations for host-host interactions, the potential model used was a type of simple point charge (SPC) model, and for guest-guest and host-guest interactions the potential used was Lennard-Jones model. In the process of MD simulation, achieving equilibrium of the studied system was recognized by stability in calculated pressure for NVT-ensemble and volume for NPT-ensemble. To understand the characteristic configurations of the structure I hydrate, the radial distribution functions (RDFs) of host-host, host-guest and guest-guest molecules as well as other properties including kinetic energy, potential energy and total energy were calculated. The results show that guest molecules interaction with host molecules cannot decompose the hydrate structure, and these results are consistent with most previous experimental and theoretical investigations that methane + ethane mixtures form structure I hydrates over the entire mixture composition range.

  2. Closing the health and nutrition gap in Odisha, India: A case study of how transforming the health system is achieving greater equity.

    Science.gov (United States)

    Thomas, Deborah; Sarangi, Biraj Laxmi; Garg, Anu; Ahuja, Arti; Meherda, Pramod; Karthikeyan, Sujata R; Joddar, Pinaki; Kar, Rajendra; Pattnaik, Jeetendra; Druvasula, Ramesh; Dembo Rath, Alison

    2015-11-01

    Health equity is high on the international agenda. This study provides evidence of how health systems can be strengthened to improve health equity in a low-income state. The paper presents a case study of how the Government of Odisha in eastern India is transforming the health system for more equitable health and nutrition outcomes. Odisha has a population of over 42 million, high levels of poverty, and poor maternal and child health concentrated in its Southern districts and among Scheduled Tribe and Scheduled Caste communities. Conducted between 2008 and 2012 with the Departments of Health and Family Welfare, and Women and Child Development, the study reviewed a wide range of literature including policy and programme documents, evaluations and studies, published and grey material, and undertook secondary analysis of state level household surveys. It identifies innovative and expanded provision of health services, reforms to the management and development of human resources for health, and the introduction of a number of cash transfer and entitlement schemes as contributing to closing the gap between maternal and child health and nutrition outcomes of Scheduled Tribes, and the Southern districts, compared to the state average. The institutional delivery rate for Scheduled Tribes has risen from 11.7% in 2005-06 to 67.3% in 2011, and from 35.6% to 79.8% for all women. The social gradient has also closed for antenatal and postnatal care and immunisation. Nutrition indicators though improving are proving slower to budge. The paper identifies how political will, committed policy makers and fiscal space energised the health system to promote equity. Sustained political commitment will be required to continue to address the more challenging human resource, health financing and gender issues. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

  3. The application of modern electric systems to T and D infrastructures to achieve EU 20/20/20 climate and energy targets

    International Nuclear Information System (INIS)

    Bonfiglio, A.; Delfino, F.; Denegri, G.B.; Invernizzi, M.; Procopio, R.; Pampararo, F.; Amann, G.; Bessede, J. L.; Luxa, A.; Monizza, G.

    2011-03-01

    This paper is the outcome of a collaboration between T and D Europe - The European Association of the Electricity Transmission and Distribution Equipment and Services Industry and the Power Systems Research Team at the University of Genoa. It presents a scientific analysis of how much modern products and systems from the electric industry contribute to the European Union's (EU) efforts to mitigate climate change (EU's Climate and Energy Policy 20/20/20 [1]). A methodology is proposed in order to quantify the possible environmental benefits in terms of efficiency increase, CO 2 reduction and a wider employ of renewable energy resources as well as of power quality improvement provided by a renewal of the European T and D infrastructures. Such methodology is based both on the identification of suitable technical KPIs (Key Performance Indicators) to be used to rank the benefits brought by the different grid upgrading measures and on the definition of suitable 'test networks', which can be employed as benchmarks to perform the numerical evaluation of the introduced KPIs. (authors)

  4. Improving antibiotic prescribing for adults with community acquired pneumonia: Does a computerised decision support system achieve more than academic detailing alone? – a time series analysis

    Directory of Open Access Journals (Sweden)

    Black James F

    2008-07-01

    Full Text Available Abstract Background The ideal method to encourage uptake of clinical guidelines in hospitals is not known. Several strategies have been suggested. This study evaluates the impact of academic detailing and a computerised decision support system (CDSS on clinicians' prescribing behaviour for patients with community acquired pneumonia (CAP. Methods The management of all patients presenting to the emergency department over three successive time periods was evaluated; the baseline, academic detailing and CDSS periods. The rate of empiric antibiotic prescribing that was concordant with recommendations was studied over time comparing pre and post periods and using an interrupted time series analysis. Results The odds ratio for concordant therapy in the academic detailing period, after adjustment for age, illness severity and suspicion of aspiration, compared with the baseline period was OR = 2.79 [1.88, 4.14], p Conclusion Deployment of a computerised decision support system was associated with an early improvement in antibiotic prescribing practices which was greater than the changes seen with academic detailing. The sustainability of this intervention requires further evaluation.

  5. The application of modern electric systems to T and D infrastructures to achieve EU 20/20/20 climate and energy targets

    Energy Technology Data Exchange (ETDEWEB)

    Bonfiglio, A.; Delfino, F.; Denegri, G.B.; Invernizzi, M.; Procopio, R.; Pampararo, F. [Department of Electrical Engineering, University of Genoa, via Opera Pia, 11 a, I-16145 Genova (Italy); Amann, G.; Bessede, J. L.; Luxa, A.; Monizza, G. [T and D Europe - The European Association of the Electricity Transmission and Distribution Equipment and Services Industry, Diamant Building, Boulevard A. Reyers 80, B 1030 Brussels (Belgium)

    2011-03-15

    This paper is the outcome of a collaboration between T and D Europe - The European Association of the Electricity Transmission and Distribution Equipment and Services Industry and the Power Systems Research Team at the University of Genoa. It presents a scientific analysis of how much modern products and systems from the electric industry contribute to the European Union's (EU) efforts to mitigate climate change (EU's Climate and Energy Policy 20/20/20 [1]). A methodology is proposed in order to quantify the possible environmental benefits in terms of efficiency increase, CO{sub 2} reduction and a wider employ of renewable energy resources as well as of power quality improvement provided by a renewal of the European T and D infrastructures. Such methodology is based both on the identification of suitable technical KPIs (Key Performance Indicators) to be used to rank the benefits brought by the different grid upgrading measures and on the definition of suitable 'test networks', which can be employed as benchmarks to perform the numerical evaluation of the introduced KPIs. (authors)

  6. Financing transformative health systems towards achievement of the health Sustainable Development Goals: a model for projected resource needs in 67 low-income and middle-income countries.

    Science.gov (United States)

    Stenberg, Karin; Hanssen, Odd; Edejer, Tessa Tan-Torres; Bertram, Melanie; Brindley, Callum; Meshreky, Andreia; Rosen, James E; Stover, John; Verboom, Paul; Sanders, Rachel; Soucat, Agnès

    2017-09-01

    The ambitious development agenda of the Sustainable Development Goals (SDGs) requires substantial investments across several sectors, including for SDG 3 (healthy lives and wellbeing). No estimates of the additional resources needed to strengthen comprehensive health service delivery towards the attainment of SDG 3 and universal health coverage in low-income and middle-income countries have been published. We developed a framework for health systems strengthening, within which population-level and individual-level health service coverage is gradually scaled up over time. We developed projections for 67 low-income and middle-income countries from 2016 to 2030, representing 95% of the total population in low-income and middle-income countries. We considered four service delivery platforms, and modelled two scenarios with differing levels of ambition: a progress scenario, in which countries' advancement towards global targets is constrained by their health system's assumed absorptive capacity, and an ambitious scenario, in which most countries attain the global targets. We estimated the associated costs and health effects, including reduced prevalence of illness, lives saved, and increases in life expectancy. We projected available funding by country and year, taking into account economic growth and anticipated allocation towards the health sector, to allow for an analysis of affordability and financial sustainability. We estimate that an additional $274 billion spending on health is needed per year by 2030 to make progress towards the SDG 3 targets (progress scenario), whereas US$371 billion would be needed to reach health system targets in the ambitious scenario-the equivalent of an additional $41 (range 15-102) or $58 (22-167) per person, respectively, by the final years of scale-up. In the ambitious scenario, total health-care spending would increase to a population-weighted mean of $271 per person (range 74-984) across country contexts, and the share of gross

  7. Achieving diagnosis by consensus

    LENUS (Irish Health Repository)

    Kane, Bridget

    2009-08-01

    This paper provides an analysis of the collaborative work conducted at a multidisciplinary medical team meeting, where a patient’s definitive diagnosis is agreed, by consensus. The features that distinguish this process of diagnostic work by consensus are examined in depth. The current use of technology to support this collaborative activity is described, and experienced deficiencies are identified. Emphasis is placed on the visual and perceptual difficulty for individual specialities in making interpretations, and on how, through collaboration in discussion, definitive diagnosis is actually achieved. The challenge for providing adequate support for the multidisciplinary team at their meeting is outlined, given the multifaceted nature of the setting, i.e. patient management, educational, organizational and social functions, that need to be satisfied.

  8. Achieving best outcomes for patients with cardiovascular disease in China by enhancing the quality of medical care and establishing a learning health-care system.

    Science.gov (United States)

    Jiang, Lixin; Krumholz, Harlan M; Li, Xi; Li, Jing; Hu, Shengshou

    2015-10-10

    China has an immediate need to address the rapidly growing population with cardiovascular disease events and the increasing number of people living with this illness. Despite progress in increasing access to services, China faces the dual challenge of addressing gaps in quality of care and producing more evidence to support clinical practice. In this Review, we address opportunities to strengthen performance measurement, programmes to improve quality of care, and national capacity to produce high-impact knowledge for clinical practice. Moreover, we propose recommendations, with implications for other diseases, for how China can immediately make use of its Hospital Quality-Monitoring System and other existing national platforms to assess and improve performance of medical care, and to generate new knowledge to inform clinical decisions and national policies. Copyright © 2015 Elsevier Ltd. All rights reserved.

  9. IL-6 blockade in systemic juvenile idiopathic arthritis - achievement of inactive disease and remission (data from the German AID-registry).

    Science.gov (United States)

    Bielak, M; Husmann, E; Weyandt, N; Haas, J-P; Hügle, B; Horneff, G; Neudorf, U; Lutz, T; Lilienthal, E; Kallinich, T; Tenbrock, K; Berendes, R; Niehues, T; Wittkowski, H; Weißbarth-Riedel, E; Heubner, G; Oommen, P; Klotsche, J; Foell, Dirk; Lainka, E

    2018-04-05

    Systemic juvenile idiopathic arthritis (sJIA) is a complex disease with an autoinflammatory component of unknown etiology related to the innate immune system. A major role in the pathogenesis has been ascribed to proinflammatory cytokines like interleukin-6 (IL-6), and effective drugs inhibiting their signaling are being developed. This study evaluates sJIA patients treated with the IL-6 inhibitor tocilizumab (TCZ) concerning clinical response rate, disease course and adverse effects in a real-life clinical setting. In 2009 a clinical and research consortium was established, including an online registry for autoinflammatory diseases (AID) ( https://aid-register.de ). Data for this retrospective TCZ study were documented by 13 centers. From 7/2009 to 4/2014, 200 patients with sJIA were recorded in the AID-registry. Out of these, 46 (19 m, 27 f, age 1-18 years) received therapy with TCZ. Long term treatment (median 23 months) has been documented in 24/46 patients who were evaluated according to Wallace criteria (active disease 6/24, inactive disease 5/24, remission 13/24 cases). Under observation co-medication were used in 40/46 cases. Adverse events were reported in 11/46 patients. The clinical response rate (no clinical manifestation, no increased inflammation parameters) within the first 12 weeks of treatment was calculated to be 35%. Out of 200 sJIA children reported in the German AID-registry, 46 were treated with TCZ, showing a clinical response rate of 35% during the first 12 weeks, and inactive disease and/or remission under medication in 75% after one year. Adverse events were seen in 24% and severe adverse events in 4%. The AID-Registry is funded by the BMBF (01GM08104, 01GM1112D, 01GM1512D).

  10. Comparisons between students' learning achievements of their conventional instruction and the science, technology and social conceptual instructional design on digestion system issue of secondary students at the 10th grade level

    Science.gov (United States)

    Wichalek, Supattra; Chayaburakul, Kanokporn; Santiboon, Toansakul

    2018-01-01

    The purposes of this action research study were 1) to develop learning activities according to the instructional designing model of science, technology, and social (STS) on Digestion Issue, 2) to compare students' learning achievements between their learning activities with the conventional instructional (CIM) and conceptual instructional designing methods of science, technology, and social (STS) on digestion system of secondary students at the 10th grade level with a sample size of 35 experimental student group of their STS learning method, and 91 controlling group in two classes in the first semester in academic year 2016. Using the 4-Instructional Innovative Lesson Plans, the Students' Learning Behaviour Observing Form, the Questionnaire on Teacher Behaviour Interaction (QTBI), the Researcher's Recording Form, the Learning Activity Form, and the Parallel Learning Achievement Test (LAT) were assessed. The results of this research have found that; the Index of Item Objective Congruence (IOC) value ranged from 0.67 to 1.00; the difficulty values were 0.47 and 0.79 for the CIM and STS methods, respectively, the discriminative validity for the LAT was ranged from 0.20 to 0.75. The reliability of the QTBI was 0.79. Students' responses of their learning achievements with the average means scores indicted of the normalized gain values of 0.79 for the STS group, and 0.50 and 0.36 for the CIM groups, respectively. Students' learning achievements of their post-test indicated that of a higher than pre-test, the pre-test and post-test assessments were also differentiated evidence at the 0.05 levels for the STS and CIM groups, significantly. The 22-students' learning outcomes from the STS group evidences at a high level, only of the 9-students' responses in a moderate level were developed of their learning achievements, responsibility.

  11. Achievement Goals and Achievement Emotions: A Meta-Analysis

    Science.gov (United States)

    Huang, Chiungjung

    2011-01-01

    This meta-analysis synthesized 93 independent samples (N = 30,003) in 77 studies that reported in 78 articles examining correlations between achievement goals and achievement emotions. Achievement goals were meaningfully associated with different achievement emotions. The correlations of mastery and mastery approach goals with positive achievement…

  12. The need for sustainable technology diffusion in mining: Achieving the use of belt conveyor systems in the German hard-rock quarrying industry

    Directory of Open Access Journals (Sweden)

    Tobias Braun

    2017-01-01

    Full Text Available The movement of raw materials can be one of the most challenging tasks in open pit mining, with truck transportation representing the largest factor in mining costs and resulting in major greenhouse gas (GHG emissions. In this study, the transportation methods of bulk materials within German hard-rock open pit mines were investigated. Approximately 450 quarries were studied for their production tonnage, lease areas, mined rock type as well as mining methods and processing equipment. The results demonstrate that 90% of the operations use truck-based transportation methods, with the remainder relying partly or completely on continuous conveyor-based systems. The installation of continuous conveyors compared to trucks represents a real alternative because of reduced dead load, reduced GHG emissions and in many cases even reduced costs. Thus, for in-pit haulage in quarries sustainable technology substitutions exist that are yet to be adopted by the German quarrying industry. As this study shows, in the future the diffusion of sustainable technologies requires site champions and large-scale case studies that demonstrate their successful introduction in the mining value chain.

  13. Addition of hydrochlorothiazide to angiotensin receptor blocker therapy can achieve a lower sodium balance with no acceleration of intrarenal renin angiotensin system in patients with chronic kidney disease.

    Science.gov (United States)

    Fuwa, Daisuke; Fukuda, Michio; Ogiyama, Yoshiaki; Sato, Ryo; Mizuno, Masashi; Miura, Toshiyuki; Abe-Dohmae, Sumiko; Michikawa, Makoto; Kobori, Hiroyuki; Ohte, Nobuyuki

    2016-01-01

    Angiotensin receptor blockers (ARBs) produce a lower sodium (Na) balance, and the natriuretic effect is enhanced under Na deprivation, despite falls in blood pressure (BP) and glomerular filtration rate (GFR). The effect of additional hydrochlorothiazide (HCTZ; 12.5 mg/day) to ARB treatment (valsartan; 80 mg/day) on glomerulotubular Na balance was evaluated in 23 patients with chronic kidney disease. Add-on HCTZ decreased GFR, tubular Na load, and tubular Na reabsorption (t(Na)), although 24-hour urinary Na excretion (U(Na)V) remained constant. Daily urinary angiotensinogen excretion (U(AGT)V, 152±10→82±17 μg/g Cre) reduced (p=0.02). Changes in tubular Na load (r(2)=0.26) and t(Na) (r(2)=0.25) correlated with baseline 24-hour U(AGT)V. Changes in filtered Na load correlated with changes in nighttime systolic BP (r(2)=0.17), but not with changes in daytime systolic BP. The change in the t(Na) to filtered Na load ratio was influenced by the change in daytime U(Na)V (β=-0.67, F=16.8), rather than the change in nighttime U(Na)V. Lower Na balance was produced by add-on HCTZ to ARB treatment without an increase of intra-renal renin-angiotensin system activity, leading to restoration of nocturnal hypertension. A further study is needed to demonstrate that the reduction of U(AGT)V by additional diuretics to ARBs prevents the progression of nephropathy or cardiovascular events. © The Author(s) 2016.

  14. Linking Student Achievement and Teacher Science Content Knowledge about Climate Change: Ensuring the Nations 3 Million Teachers Understand the Science through an Electronic Professional Development System

    Science.gov (United States)

    Niepold, F.; Byers, A.

    2009-12-01

    The scientific complexities of global climate change, with wide-ranging economic and social significance, create an intellectual challenge that mandates greater public understanding of climate change research and the concurrent ability to make informed decisions. The critical need for an engaged, science literate public has been repeatedly emphasized by multi-disciplinary entities like the Intergovernmental Panel on Climate Change (IPCC), the National Academies (Rising Above the Gathering Storm report), and the interagency group responsible for the recently updated Climate Literacy: The Essential Principles of Climate Science. There is a clear need for an American public that is climate literate and for K-12 teachers confident in teaching relevant science content. A key goal in the creation of a climate literate society is to enhance teachers’ knowledge of global climate change through a national, scalable, and sustainable professional development system, using compelling climate science data and resources to stimulate inquiry-based student interest in science, technology, engineering, and mathematics (STEM). This session will explore innovative e-learning technologies to address the limitations of one-time, face-to-face workshops, thereby adding significant sustainability and scalability. The resources developed will help teachers sift through the vast volume of global climate change information and provide research-based, high-quality science content and pedagogical information to help teachers effectively teach their students about the complex issues surrounding global climate change. The Learning Center is NSTA's e-professional development portal to help the nations teachers and informal educators learn about the scientific complexities of global climate change through research-based techniques and is proven to significantly improve teacher science content knowledge.

  15. Achievement report on contract research. Large-scale project - Results of 1st-phase research and development of MHD power generation system; Plant system no hyoka. Ogata project dai 1 ki MHD hatsuden system kenkyu kaihatsu seika hokokusho

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1976-03-01

    Described in detail involving the results of component development, assessment, and the indication of problems are the power generation channel, superconductive magnets and a helium refrigeration and liquefaction unit, seeds collector, heat exchanger, combustor, etc. Described involving the result and effect of power generation system research and development and the indication of problems is the research on Mark V and Mark VI operation tests. Described in relation to thermal performance calculation, economic effectiveness calculation, and environmental conservation involving an MHD (magnetohydrodynamic) power plant are the combustion of heavy oil, combustion of natural gas, plant having a 1,000MW power generator as its base load, control of NOx and sulfur in MHD power generation, etc. As for planning for the next stage, the configuration of a 10MW MHD power generation plant, its equipment, construction cost, and preliminary element research, etc., are described. Furthermore, propositions are presented concerning future plans and the prospect of commercial MHD power generators, technological ripple effects due to MHD power generation research and development, and research and development in the future. (NEDO)

  16. Entrepreneur achievement. Liaoning province.

    Science.gov (United States)

    Zhao, R

    1994-03-01

    This paper reports the successful entrepreneurial endeavors of members of a 20-person women's group in Liaoning Province, China. Jing Yuhong, a member of the Family Planning Association at Shileizi Village, Dalian City, provided the basis for their achievements by first building an entertainment/study room in her home to encourage married women to learn family planning. Once stocked with books, magazines, pamphlets, and other materials on family planning and agricultural technology, dozens of married women in the neighborhood flocked voluntarily to the room. Yuhong also set out to give these women a way to earn their own income as a means of helping then gain greater equality with their husbands and exert greater control over their personal reproductive and social lives. She gave a section of her farming land to the women's group, loaned approximately US$5200 to group members to help them generate income from small business initiatives, built a livestock shed in her garden for the group to raise marmots, and erected an awning behind her house under which mushrooms could be grown. The investment yielded $12,000 in the first year, allowing each woman to keep more than $520 in dividends. Members then soon began going to fairs in the capital and other places to learn about the outside world, and have successfully ventured out on their own to generate individual incomes. Ten out of twenty women engaged in these income-generating activities asked for and got the one-child certificate.

  17. Nebraska STARS: Achieving Results

    Science.gov (United States)

    Roschewski, Pat; Isernhagen, Jody; Dappen, Leon

    2006-01-01

    In 2000, the state of Nebraska passed legislation requiring the assessment of student performance on content standards, but its requirements were very different from those of any other state. Nebraska created what has come to be known as STARS (School-based Teacher-led Assessment and Reporting System). Under STARS, each of Nebraska's nearly 500…

  18. BIBLIOGRAPHY ON ACHIEVEMENT. SUPPLEMENT I.

    Science.gov (United States)

    Harvard Univ., Cambridge, MA. Graduate School of Education.

    THIS BIBLIOGRAPHY SUPPLEMENT LISTS MATERIALS ON VARIOUS ASPECTS OF ACHIEVEMENT. APPROXIMATELY 60 REFERENCES ARE PROVIDED TO DOCUMENTS DATING FROM 1961 TO 1966. JOURNALS, BOOKS, AND REPORT MATERIALS ARE LISTED. SUBJECT AREAS INCLUDED ARE ACHIEVEMENT LEVEL, ACADEMIC ACHIEVEMENT, ACHIEVEMENT MOTIVATION, UNDERACHIEVERS, PROBABILITY ESTIMATES, AND…

  19. Research and development project for large industrial technologies in fiscal 1989. Achievement report on research and development of manganese nodule mining system - Volume 2/6 (Edition for total system - experiment program); 1989 nendo mangan dankai saiko system no kenkyu kaihatsu seika hokokusho. 2/6. Total system (jikken keikaku) hen

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1990-03-01

    With an objective to ensure non-ferrous metal resources such as nickel, cobalt, copper and manganese, and enhance the ocean development technologies, research and development has been performed on a technology to mine by using the fluid dredge system the manganese nodules existing in ocean bottoms as deep as 4,000 to 6,000 m. This paper summarizes the achievements in fiscal 1989. This fiscal year has reviewed and rationalized the experiment program for the purpose of largely reducing the experimental expense without damaging the purpose and achievement of the experiment. In the rationalized program, such programs were established as the dock side test at the quay and off shore of the Kobe Shipyard, a comprehensive trial operation in the sea area with depth of about 2,000 m, and comprehensive experiments in the sea area around 9 degrees 10 minutes north latitude and 146 degrees 30 minutes west longitude with depth of 5,150 m. Based on these programs, discussions were given on the personnel plan, operation management, fuel, and lubrication oil for the experimental vessel. In addition, discussions were given on the operation, maintenance management, operation management, communications, safety control, and hurricane countermeasures as the experiment implementation procedures. Furthermore, such discussions were given as investigation and selection of the environmental effects and the experimental sea areas for the experiment system. (NEDO)

  20. Fiscal 2000 achievement report on the development of energy conservation/environment purification system using cleaning effect of optical irradiation; 2000 nendo hikari clean gijutsu wo mochiita sho energy kankyo joka system no kaihatsu seika hokokusho

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-03-01

    The research aims to develop materials and apparatuses for the purification of atmosphere using titanium dioxide that exhibits a powerful oxidizing capability when irradiated with light. A study is conducted to find out an optimum composition for a photocatalytic fluorocarbon polymer sheet suitable for use in a denitration apparatus. A high density fluorocarbon polymer sheet composed of TiO{sub 2} modified with 0.3% of Pd/absorbent zeolite/fluorocarbon polymer PTFE (polytetrafluoroethylene) =48-63/24-36/10-20 is found to show high denitration efficiency, and this achieves the denitration efficiency goal. As for sheet thickness, 0.75mm is found to be enough. The sheet experiences some hardening in an accelerated exposure test, but does not change much in a surface gloss test or a chalking test. Although a slight reduction is observed in denitration efficiency, yet the durability goal is achieved. In the effort to develop an energy conservation type air cleaning apparatus, field tests and experiments are repeatedly conducted. As for photodenitration in the cleaning apparatus, the number of photodenitration stages and the magnitude of equimolar adsorption area necessary for achieving an 80% denitration rate is calculated from the relations of the NOx concentration profile and the denitration rate in the equimolar adsorption module to (gas flow rate/module surface), and the result shows that the initially intended goal is achieved. (NEDO)

  1. Report on achievements in proliferation project to assist introduction of environment harmonizing type coal utilization system in fiscal 1998. Joint demonstration project for CMG recovery and utilization system in fiscal 1998 (recovering facilities); Kankyo chowagata sekitan riyo system donyu shien nado fukyu taisaku jigyo. 1998 nendo CMG kaishu riyo system kyodo system kyodo jissho jigyo (kaishu setsubi)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-09-01

    This paper describes the achievements of the discussions in fiscal 1998 on the recovering system for coal bed methane gas to be supplied to the city of Tieling in China. The paper puts on record the associated documents, and figures and drawings. The associated documents appearing in the paper include the table for explosion-proof examination on the recovering devices, a parts list for the RK-3A type test drilling machine, and its operation manual. Specifications for the test drilling machine (including those for the sealing pumps), specifications for the mouth facilities, and device lists are shown. Test drilling device arrangement drawings and standard drilling record table are also described. Central blower specifications, a back-fire preventing device, a device to prevent well exterior from freezing, and a summarized drawing for drain remover for gas induction for the Daixing mine are explained. The schemes for induction and sealing, specifications and procedures for observation devices are shown. Specifications for sealing materials and the centralized monitoring facilities are also touched on. The safety measures, measures taken for power failure in the centralized monitoring facilities, and the control organization are described. Test drilling cost simulation and environment assessing methods are also described. The figures and drawings presented include the topographic map, Daixing mine cavity drawing, pipeline network, and chart for representative test drilling columns near the coal beds were also presented. (NEDO)

  2. CAMS achievements in 1995

    International Nuclear Information System (INIS)

    Berg, Oe.; Fantoni, P.; Iguchi, Y.; Meyer, G.; Soerensen, A.; Dyck, C. van.

    1996-01-01

    CAMS (Computerized Accident Management Support) is a system being developed as a joint research activity at the Halden Reactor Project with additional financing from the Swedish Nuclear Inspectorate (SKI) and the Nordic NKS/RAK-2 project. Three types of users are envisaged: the staff in the control room, the staff in the technical support centre and the staff at a national emergency centre. It is still an experimental system. The Swedish Nuclear Inspectorate kindly accepted to test CAMS at a safety exercise on the 4th of May, 1995. CAMS is designed assuming automatic data transfer from the plant. Missing the data link, a simulator running in the next room was updated now and then with data received by phone. As seen from CAMS, it did not matter if the data came from a fake plant or from a real plant, except that the data were delayed. Overall, it seemed that CAMS can be a very important tool for a national authority. A data link from the plant would increase its usefulness. Several comments on design features were collected and will be used to improve the system. The model needs more inputs to control the main parameters, and a larger repertoire of fault conditions should be put into the model. In the second half of 1995 the work on CAMS has concentrated upon designing new modules for signal validation, tracking simulation and state identification. This will provide better capabilities for on-line monitoring and assessment of the plant state. Further, it has been proposed to introduce Probabilistic Safety Assessment (PSA) to assist in risk monitoring. A first prototype has been made on a personal computer showing the main features of such a PSA module. (au)

  3. Attitude Towards Physics and Additional Mathematics Achievement Towards Physics Achievement

    Science.gov (United States)

    Veloo, Arsaythamby; Nor, Rahimah; Khalid, Rozalina

    2015-01-01

    The purpose of this research is to identify the difference in students' attitude towards Physics and Additional Mathematics achievement based on gender and relationship between attitudinal variables towards Physics and Additional Mathematics achievement with achievement in Physics. This research focused on six variables, which is attitude towards…

  4. Strengthening Health Systems to Accelerate Achievement of ...

    African Journals Online (AJOL)

    AJRH Managing Editor

    to urban area due to unavailability of the service facilities. ... established to improve access and quality of health care in Ghana. ... programmes de planification et de services de santé à base communautaire ont été mis en place pour améliorer .... pregnancies, they can reduce the body's reserve ... emergency prenatal care.

  5. Nuclear power station achievement 1968-1980

    International Nuclear Information System (INIS)

    Howles, L.R.

    This report reviews and gives an analysis of the achievement of operating nuclear power stations in the Western world on three relevant bases: (1) both annual and cumulative achievement of all nuclear power stations at a particular time; (2) cumulative achievement of all nuclear power stations at the end of the first and subsequent years of their lives to show trends with age; (3) achievement based on refuelling period considerations. Nowhere in the report are any operating details ignored, omitted or eliminated in the method of analysis. Summarising the results of the reviews shows: an improvement with time from initial electricity generation on all bases; that initially, larger sizes of reactor/turbine operate less well than smaller sizes (except for PHWR's); that after an initial number of years, the largest size units operate as well as the intermediate and smaller sizes, or better in the PHWR case; that a 75 per cent cumulative load factor achievement in the middle years of a reactor/turbines life can be expected on the refuelling period considerations base; that at June 1980, 35 nuclear power stations achieved an annual load factor over 75 per cent; that the above achievement was possible despite the repercussions following the Three Mile Island 'accident' and the shutdowns in the USA for piping system seismic adequacy checks required by the Nuclear Regulatory Commission for five nuclear power stations; and that even when reactors/turbines are reaching towards the end of their design life, there is no rapid deterioration in their achievements. (author)

  6. An Aussie quiet achiever

    International Nuclear Information System (INIS)

    Wallace, Paula

    2012-01-01

    Full text: Maker of the 20 kilowatt Eco Whisper Turbine, Renewable Energy Solutions Australia believes the technology represents a game changer and major advance in wind power, attracting interest globally. The company recently completed the second commercial installation of the technology, both of which are in Victoria. “This marks a crucial milestone in our evolution and adoption of renewable energy,” RESA business development manager Michael Le Messurier said. The EWT's virtually silent operation and ability to capture up to 30% more energy than traditional three-bladed designs make it well-suited to mid-sized commercial, manufacturing and industrial facilities wanting to reduce their greenhouse emissions and lower the impact of the carbon tax. Standing at 21m, it has the ability to generate 45,000-plus kilowatt hours per annum on windy sites. The EWT is built from a number of interdependent systems, including the blade array, the control system and inverter. The blade array consists of 30 forward- swept heavily cambered blades joined by circumferential cowls at the blade tip and midway along the blade length. Aesthetically it is the major differentiator when compared to traditional three- bladed wind turbines. The roots of the blades are faired smoothly into a large diameter conical nose fairing. The combination of features reflects key aspects of the EWT design philosophy, namely, maximum power production efficiency in very light winds and minimum noise at all wind speeds. The EWT blade array has high solidity (around 60%) as compared to typical three-bladed wind turbines which have low solidity (5-7%). As a result the EWT will have a lower starting speed as it is able to effectively harness low wind speeds. The blade array has a full circumferential tip cowl. The cowl manages the merger of the high and low pressure air flows that travel outward along the front and rear of the blade. Controlling the flows means less lost power at the tip and less noise

  7. Physical Activity and Academic Achievement

    Centers for Disease Control (CDC) Podcasts

    This podcast highlights the evidence that supports the link between physical activity and improved academic achievement. It also identifies a few actions to support a comprehensive school physical activity program to improve academic achievement.

  8. Healthy Eating and Academic Achievement

    Centers for Disease Control (CDC) Podcasts

    This podcast highlights the evidence that supports the link between healthy eating and improved academic achievement. It also identifies a few actions to support a healthy school nutrition environment to improve academic achievement.

  9. Report on achievements in fiscal 1998. Development of technologies to put photovoltaic power generation systems into practical use - Demonstrative research on photovoltaic power generation system (Research on multi-hybrid photovoltaic power generation system); 1998 nendo taiyoko hatsuden system jitsuyoka gijutsu kaihatsu seika hokokusho. Taiyoko hatsuden system no jissho kenkyu (taiyoko hatsuden multi hybrid system no kenkyu)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-03-01

    A multi-hybrid system integrating photovoltaic and wind power generation systems with the existing diesel engine power generation system was assumed for installation in power systems in islands. System analyzing simulation and economic performance analyses were performed to consider system configurations suitable for islands from the viewpoints of system stability and economic performance. The work was progressed by dividing the subject into (1) research on the system configurations, and (2) studies on the economic performance. In performing either work, the power demand was classified as large (in Miyako Island), medium (in Kume Island) and small (in Tarama Island), and the introduction years into 1997, 2000, and 2005. In Item (1), the system parameter specifications were put into order, and the system analyzing simulation was performed, wherein it was verified that the system will be stabilized by introducing a system stabilizing equipment (batteries and an inverter) and by limiting the output from the wind power generation. In Item (2), it was made clear that the power generation cost is equivalent to or lower than the present cost, making reduction in fuel consumption possible. It was also disclosed that the introduction is most effective in small islands, and drop in the power generation amount due to limiting the output from the wind power generation is small. (NEDO)

  10. Achievement report on developing superconductor power applied technologies in fiscal 1999 (1). Research and development of superconductor wire materials, research and development of superconductor power generators, research of total systems, research and development of freezing systems, and verification tests; 1999 nendo chodendo denryoku oyo gijutsu kaihatsu seika hokokusho. 1. Chodendo senzai no kenkyu kaihatsu / chodendo hatsudenki no kenkyu kaihatsu / total system no kenkyu / reito system no kenkyu kaihatsu / jissho shiken

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-03-01

    With an objective to achieve higher efficiency, higher density, and higher stability in power systems, research and development has been performed on superconductor power applied technologies. This paper summarizes the achievements thereof in fiscal 1999. In research and development of the superconductor wire materials, decrease in loss and increase in capacity of the conductors were progressed for the Nb{sub 3}Sn wire material, whereas its mechanical properties and stability were evaluated. In research and development of the superconductor generators, an ultra high speed responding generator was verified of its healthiness in a sudden short circuit test. A linkage test with an operating 77-kV system was performed, wherein verification was given that the superconductor generator can be operated stably against various disturbances. In research and development of the freezing systems, an improved system was structured, which achieved operation of 11,390 hours in a single system as a result of the high reliability of the oil-free structure. In the verification tests, the ultra high speed responding model generator was connect to the freezing system to give such tests as load test, onerous test, actuation test by using the M-G system, and 77-kV system linkage test. The functions, reliability, and durability of the system were verified, and different data were acquired. (NEDO)

  11. Achievement report for fiscal 2000 on research and development of human cooperating and coexisting robot system. Research and development of rationalization in oil refining system; 2000 nendo ningen kyocho kyozongata robot system kenkyu kaihatsu seika hokokusho. Sekiyu seisei system gorika kenkyu kaihatsu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-06-01

    It is intended to develop a human cooperating and coexisting robot system that can move around freely during operation and shutdown of a oil refining plant to perform different works. This paper describes the achievements in fiscal 2000. With regard to the navigation and maintenance work functions, design was made on the robot induction system and its conception to perform the works after the robot has reached a place of the work. The specifications required for the robot supporting agent were made clear, and the constituting modules were designed to exchange information with the robot. Specifications were compiled for a portable remote operation device intended of operating different vehicles. Investigations were carried out on such protection technologies as interference check and shock absorbing materials to protect the robot platform. A method was developed to acquire posture and motion patterns of a human demonstrator, using only the upper half of the body, from the images captured by a head-mounted camera. Discussions were given on the specifications, systems and image processing algorithms required for vision-navigated autonomous walking, whose practicability was verified. Autonomous walking by means of map-based guidance, and hand operating technologies were also discussed. (NEDO)

  12. Students' Achievement Goals, Learning-Related Emotions and Academic Achievement

    Directory of Open Access Journals (Sweden)

    Marko eLüftenegger

    2016-05-01

    Full Text Available In the present research, the recently proposed 3x2 model of achievement goals is tested and associations with achievement emotions and their joint influence on academic achievement are investigated. The study was conducted with 388 students using the 3x2 Achievement Goal Questionnaire including the six proposed goal constructs (task-approach, task-avoidance, self-approach, self-avoidance, other-approach, other-avoidance and the enjoyment and boredom scales from the Achievement Emotion Questionnaire. Exam grades were used as an indicator of academic achievement. Findings from CFAs provided strong support for the proposed structure of the 3x2 achievement goal model. Self-based goals, other-based goals and task-approach goals predicted enjoyment. Task-approach goals negatively predicted boredom. Task-approach and other-approach predicted achievement. The indirect effects of achievement goals through emotion variables on achievement were assessed using bias-corrected bootstrapping. No mediation effects were found. Implications for educational practice are discussed.

  13. Achievement report for fiscal 1998 on development of wide-area energy utilization network system. Eco-energy urban system (Research of systematization technology and evaluation technology out of energy system designing technology researches); Koiki energy riyo network system kaihatsu (eko energy toshi system) 1998 nendo seika hokokusho. Energy system sekkei gijutsu no kenkyu no uchi system ka gijutsu hyoka gijutsu no kenkyu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-03-01

    For the realization of urban society respecting enhanced energy efficiency and environmental protection, cities and surrounding industrial facilities are investigated for the development of element technologies involving energy recovery, conversion, transportation, storage, delivery, utilization, etc., and for the compounding of urban energy systems. In the study of the effect of introduction, assumption is made of delivery of heat to an urban heat accumulation district from a plant equivalent to a district air-conditioning system which is covered by the existing technologies. Also assumed are the delivery of exhaust heat to the said plant utilizing eco-energy element technologies and the replacement of existing technologies by eco-energy element technologies. Comparison is established in terms of energy efficiency, environmental protection, and economy, and then it is found that the eco-energy element technologies for the utilization of exhaust heat are in all cases superior to the conventional technologies as far as energy efficiency and environmental protection are concerned. It is found, however, that they are inferior from the economic viewpoint. The energy efficiency technology in heat transportation is superior to the existing technology in energy efficiency and environmental protection but roughly equal to the existing ones in economy. (NEDO)

  14. Achieving single channel, full duplex wireless communication

    KAUST Repository

    Choi, Jung Il; Jain, Mayank; Srinivasan, Kannan; Levis, Phil; Katti, Sachin

    2010-01-01

    This paper discusses the design of a single channel full-duplex wireless transceiver. The design uses a combination of RF and baseband techniques to achieve full-duplexing with minimal effect on link reliability. Experiments on real nodes show the full-duplex prototype achieves median performance that is within 8% of an ideal full-duplexing system. This paper presents Antenna Cancellation, a novel technique for self-interference cancellation. In conjunction with existing RF interference cancellation and digital baseband interference cancellation, antenna cancellation achieves the amount of self-interference cancellation required for full-duplex operation. The paper also discusses potential MAC and network gains with full-duplexing. It suggests ways in which a full-duplex system can solve some important problems with existing wireless systems including hidden terminals, loss of throughput due to congestion, and large end-to-end delays. Copyright 2010 ACM.

  15. Modifications to LLNL Plutonium Packaging Systems (PuPS) to achieve ASME VIII UW-13.2(d) Requirements for the DOE Standard 3013-00 Outer Can Weld

    International Nuclear Information System (INIS)

    Riley, D; Dodson, K

    2001-01-01

    The Lawrence Livermore National Laboratory (LLNL) Plutonium Packaging System (PuPS) prepares packages to meet the DOE Standard 3013 (Reference 1). The PuPS equipment was supplied by the British Nuclear Fuels Limited (BNFL). The DOE Standard 3013 requires that the welding of the Outer Can meets ASME Section VIII Division 1 (Reference 2). ASME Section VIII references to ASME Section IX (Reference 3) for most of the welding requirements, but UW-13.2 (d) of Section VIII requires a certain depth and width of the weld. In this document the UW-13.2(d) requirement is described as the (a+b)/2t s ratio. This ratio has to be greater than or equal to one to meet the requirements of UW-13.2(d). The Outer Can welds had not been meeting this requirement. Three methods are being followed to resolve this issue: (1) Modify the welding parameters to achieve the requirement, (2) Submit a weld case to ASME that changes the UW-13.2(d) requirement for their review and approval, and (3) Change the requirements in the DOE-STD-3013. Each of these methods are being pursued. This report addresses how the first method was addressed for the LLNL PuPS. The experimental work involved adjusting the Outer Can rotational speed and the power applied to the can. These adjustments resulted in being able to achieve the ASME VIII, UW-13.2(d) requirement

  16. Systemic chemotherapy and extracorporeal photochemotherapy for T3 and T4 cutaneous T-cell lymphoma patients who have achieved a complete response to total skin electron beam therapy

    International Nuclear Information System (INIS)

    Wilson, Lynn D.; Licata, Anita L.; Braverman, Irwin M.; Edelson, Richard L.; Heald, Peter W.; Feldman, Andrea M.; Kacinski, Barry M.

    1995-01-01

    Purpose: To evaluate the impact of systemic adjuvant therapies on relapse-free (RFS) and overall survival (OS) of cutaneous T-cell lymphoma (CTCL) patients treated with total skin electron beam therapy (TSEBT). Methods and Materials: Between 1974 and 1990, TSEBT (36 Gy at 1 Gy/day; 9 weeks; 6 MeV electrons) was administered with curative intent to a total of 163 CTCL (mycosis fungoides) patients using six fields supplemented by orthovoltage boosts (120 kvp, 1 Gy x 20) to the perineum, soles of feet, and apical scalp (120 kvp, 2 Gy x 3). In this group, all patients who achieved a clinical complete response or a good partial response were offered one of two competing regimens of either adjuvant doxorubicin/cyclophosphamide or adjuvant extracorporeal photochemotherapy (ECP). Results: When the results for the group who achieved a complete response (CR) to TSEBT were analyzed, OS for T1 and T2 patients was excellent (85-90% at 5-10 years) and not improved by either adjuvant regimen. However, T3 and T4 patients who received either adjuvant doxorubicin/cyclophosphamide (75% at 3 years) or adjuvant ECP (100% at 3 years) had better overall survival than those who received neither adjuvant regimen (∼ 50% at 5 years). The difference between the OS curves for those who received ECP vs. those who received no adjuvant therapy approached statistical significance (p < 0.06), while a significant survival benefit from the addition of chemotherapy for TSEBT complete responders was not observed. Neither adjuvant therapy provided benefit with respect to relapse free survival after TSEBT. Conclusions: These results suggest that an adjuvant nontoxic regimen of extracorporeal photochemotherapy may prolong survival in advanced stage CTCL patients who have achieved a complete remission after TSEBT. The combination of doxorubicin/cyclophosphamide had no significant impact on overall survival in those patients who achieved CR to TSEBT, and neither adjuvant therapy had an impact on relapse

  17. Achievement report for fiscal 1999 on research and development of technologies for medical welfare equipment. Rehabilitation system for upper limbs and lower limbs; 1999 nendo iryo fukushi kiki gijutsu kenkyu kaihatsu seika hokokusho. Shintai kino rihabiri shien system

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-05-01

    This project aims to develop physical function measuring and training systems equipped with a variety of feedback utilities and widely applicable to the prevention of the elderly from physical function degradation, to the preservation of physical functions, and to their recovery from mild physical difficulties, thereby helping the elderly enjoy independence and participation in social activities. Possibilities will be studied of providing them with engineering support in the field of exercise therapy through the analysis of the characteristics of old people's movement, and the findings will be applied to the designing and assessment of welfare and nursing equipment and also fed back to their development environment. In the gait training system, the suspension force is adjusted according to data from the force plate and various position sensors, and the system produces an effect similar to that of walking in the water. The lower limb rehabilitation system facilitates the treatment of the aged or handicapped people, and patients suffering from cerebral disorders, at any of their physical positions from lying to standing. The upper limb training support system is to provide motivation for the aged or handicapped people suffering from mild difficulties in their upper limbs. In this fiscal year, basic designs have been prepared for the gait training system and the lower limb rehabilitation system, and a preparatory survey is conducted for the upper limb training support system. (NEDO)

  18. Achievement report for fiscal 1998 on Simple Operation Type CAD/CAM System Development through International Cooperation; 1998 nendo 'kan'i sosagata denshi sekkei seian shien system no kaihatsu ni kansru kenkyu kyoryoku' ni kansuru hokokusho

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-03-01

    The subject project is implemented in the fields of automobiles and their parts, electrical home appliances and their parts, and textile and apparel. In the field of automobiles and their parts, a prototype is developed of an integrated information management system which is to serve between corporation head offices and assembling businesses overseas, and another prototype is developed of an inter-business technical data serving system which is to serve between overseas assembling businesses and supporting businesses, both involving Japan, Indonesia, and Thailand. In the field of electrical home appliances and their parts, a prototype is developed of an electronic catalog system in a joint endeavor with research institutes of Indonesia, Malaysia, Singapore, and Thailand, and a demonstration test is conducted. A design concurrent engineering system is developed by Japan and Malaysian research institutes. In the field of textile and apparel, prototypes are developed, by Japanese, Chinese, and Indonesian apparel manufactures, of an apparel manufacturing specification system, international EDI (electronic data interchange) system, translation system, and a CAD (computer-aided design)/CAM (computer-aided manufacturing) data interchange system. (NEDO)

  19. Fiscal 2000 achievement report on the research and development of medical and welfare apparatus/technology. Home rehabilitation system for aphasia patients; 2000 nendo iryo fukushi kiki gijutsu kenkyu kaihatsu seika hokokusho. Shitsugosho zaitaku rehabilitation shien system

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-05-01

    In the effort to develop an authoring system for assistance programs, a self-training system to enhance home rehabilitation, a remote rehabilitation evaluation/diagnosis supporting system, and a communication assisting system, the systems developed in the preceding fiscal years were customized and, together with their operation manuals, introduced to seven hospitals and subjected to evaluation. The results were analyzed, and improvement centering on the ease of operation was carried out. Various development efforts were exerted to improve on what were strongly demanded. As for the aphasiac/caregiver interface, it was distributed to every hospital concerned. There was a demand for immediate introduction, and then the interface was developed into a practical tool to satisfy the demand. This enabled aphasiac patients to receive training stimuli effectively through various sense organs. (NEDO)

  20. Achievement report for fiscal 2000 on the phase II research and development for the hydrogen utilizing international clean energy system technology (WE-NET). Task 1. Investigations and researched on system assessment; 2000 nendo suiso riyo kokusai clean energy system gijutsu (WE-NET) dai 2 ki kenkyu kaihatsu. Task 1. System hyoka ni kansuru chosa kenkyu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-03-01

    This paper describes the achievements in fiscal 2000 from the WE-NET Phase II for Task-1. Technologies drawing attentions relate to fuel cell driven automobiles and hybrid automobiles in the field of utilizing hydrogen derived from reproducible energies and fossil energies, and fuel cell co-generation and micro gas turbine co-generation in the field of electric power generation. Hydrogen reformed from gasoline on board the automobile as the fuel for fuel cell driven automobiles, hydrogen as a by-product of coke furnace off-gas (COG), and reproducible energy hydrogen have the same fuel consumption performance as in the hybrid automobiles. Particularly the COG is low in cost, and has large supply potential. Liquefied hydrogen is as promising as compressed hydrogen in view of the cost for automotive hydrogen supply stations. What has high economic performance as the self-sustaining systems for islands are photovoltaic and wind power generation, and the system using hydrogen as the secondary energy. Since much of the reproducible energies is used for electric power demand in Japan, the by-product hydrogen and the reformed hydrogen in an amount of 9.3 billion Nm{sup 3}/year would take care of majority of the demand in view of the short time period. For a longer time span, hydrogen originated from the reproduced energies in the Pan-Pacific Region should be introduced. (NEDO)