Sample records for hormesis historical perspective

  1. Historical foundations of hormesis. (United States)

    Calabrese, Edward J


    The present paper provides an historical assessment of the concept of hormesis and its relationship to homeopathy and modern medicine. It is argued that the dose-response concept was profoundly influenced by the conflict between homeopathy and traditional medicine and that decisions on which dose-response model to adopt were not based on "science" but rater on historical antipathies. While the historical dispute between homeopathy and traditional medicine has long since subsided, their impact upon the field has been enduring and generally unappreciated, profoundly adversely affecting current drug development, therapeutic strategies and environmental risk assessment strategies and policies.

  2. Hormesis: why it is important to biogerontologists. (United States)

    Calabrese, Edward J; Iavicoli, Ivo; Calabrese, Vittorio


    This paper offers a broad assessment of the hormetic dose response and its relevance to biogerontology. The paper provides detailed background information on the historical foundations of hormesis, its quantitative features, mechanistic foundations, as well as how the hormesis concept could be further applied in the development of new therapeutic advances in the treatment of age-related diseases. The concept of hormesis has direct application to biogerontology not only affecting the quality of the aging process but also experimental attempts to extend longevity.

  3. Econophysics: historical perspectives


    Daniel, G.; Sornette, D.


    Econophysics embodies the recent upsurge of interest by physicists into financial economics, driven by the availability of large amount of data, job shortage in physics and the possibility of applying many-body techniques developed in statistical and theoretical physics to the understanding of the self-organizing economy. This brief historical survey emphasizes that Econophysics has many historical precursors, and is in fact rooted in a continuous cross-fertilization between economics and phy...

  4. Energy Sources: An Historical Perspective. (United States)

    Perry, Constance M.


    Putting the present energy situation into an historical perspective provides meaning to today's energy concerns and demonstrates how important energy has always been to our life style. Primary energy sources of the United States from 1850 to the present are examined. (RM)

  5. Basavarajeeyam: A historical perspective. (United States)

    Nishteswar, K


    Basavarajeeyam is an important handbook for an Ayurvedic physician of Andhra region. It is a bilingual work and the content was presented in Sanskrit and Telugu languages. With regard to the place and date of Basavarajeeyam there is no common opinion among the present day scholars. Pt Govardhana Sharma Changani in his introduction to the Sanskrit version of Basavarajeeyam exposed a historical profile of Basavrajeeyam picturising him as Basava who was a staunch follower of Veerashaivism and a contemporary of king Bijjala (end of 12(th) cent. AD). The same statement is carried out in the works of Ayurvedic Itihasa written by Atredeva Vidyawalkan and Acharya Priyavrata Sharma. It appears that the historical evidence shown by these scholars is one sided and cannot stand any reason. Basavraju stated that he had started writing this work after a thorough study of many works such as Charaka, Nithyanatheeyam (1360 AD), Revenakalpam, Pujyapadiyam, Bahatam, Kashikhandam (1435 AD) etc. Basavraju has faithfully reproduced certain chapter of Vaidyachintamani, which is considered to be a work of 15(th) century. Basavraju not only mentioned Phirangiroga in the index of diseases described by him at the end of the book, but also indicated Phirangichekka (Madhusnuhi) in the management of Meharoga and Granthi. By this evidence Basavarajiyam should be considered as the work of post Bhavaprakasha period. Basavraju indicates in the Gulmaroga Chikitsa that Sankhadravaka should be administered in the dose of 'Ekanni'. The name Ekanni was given for a copper coin which came in to circulation of money during British India produced from Madras mint (1794 AD). Based on these internal evidences, it can be safely concluded that Basavraju belong to 18(th)century.

  6. Nutritional Hormesis and Aging


    Hayes, Daniel P.


    Nutritional hormesis has the potential to serve as a pro-healthy aging intervention by reducing the susceptibility of the elderly to various chronic degenerative diseases and thereby extending human healthspan. Supportive evidence for nutritional hormesis arising from essential nutrients (vitamins and minerals), dietary pesticides (natural and synthetic), dioxin and other herbicides, and acrylamide will be reviewed and discussed.

  7. Nutritional hormesis and aging. (United States)

    Hayes, Daniel P


    Nutritional hormesis has the potential to serve as a pro-healthy aging intervention by reducing the susceptibility of the elderly to various chronic degenerative diseases and thereby extending human healthspan. Supportive evidence for nutritional hormesis arising from essential nutrients (vitamins and minerals), dietary pesticides (natural and synthetic), dioxin and other herbicides, and acrylamide will be reviewed and discussed.

  8. Critical perspectives on historical collapse. (United States)

    Butzer, Karl W; Endfield, Georgina H


    Historical collapse of ancient states or civilizations has raised new awareness about its possible relevance to current issues of sustainability, in the context of global change. This Special Feature examines 12 case studies of societies under stress, of which seven suffered severe transformation. Outcomes were complex and unpredictable. Five others overcame breakdown through environmental, political, or socio-cultural resilience, which deserves as much attention as the identification of stressors. Response to environmental crises of the last millennium varied greatly according to place and time but drew from traditional knowledge to evaluate new information or experiment with increasing flexibility, even if modernization or intensification were decentralized and protracted. Longer-term diachronic experience offers insight into how societies have dealt with acute stress, a more instructive perspective for the future than is offered by apocalyptic scenarios.

  9. Hormesis in aging. (United States)

    Rattan, Suresh I S


    Hormesis in aging is represented by mild stress-induced stimulation of protective mechanisms in cells and organisms resulting in biologically beneficial effects. Single or multiple exposure to low doses of otherwise harmful agents, such as irradiation, food limitation, heat stress, hypergravity, reactive oxygen species and other free radicals have a variety of anti-aging and longevity-extending hormetic effects. Detailed molecular mechanisms that bring about the hormetic effects are being increasingly understood, and comprise a cascade of stress response and other pathways of maintenance and repair. Although the extent of immediate hormetic effects after exposure to a particular stress may only be moderate, the chain of events following initial hormesis leads to biologically amplified effects that are much larger, synergistic and pleiotropic. A consequence of hormetic amplification is an increase in the homeodynamic space of a living system in terms of increased defence capacity and reduced load of damaged macromolecules. Hormetic strengthening of the homeodynamic space provides wider margins for metabolic fluctuation, stress tolerance, adaptation and survival. Hormesis thus counter-balances the progressive shrinkage of the homeodynamic space, which is the ultimate cause of aging, diseases and death. Healthy aging may be achieved by hormesis through mild and periodic, but not severe or chronic, physical and mental challenges, and by the use of nutritional hormesis incorporating mild stress-inducing molecules called hormetins. The established scientific foundations of hormesis are ready to pave the way for new and effective approaches in aging research and intervention.


    Directory of Open Access Journals (Sweden)

    Tomás A. Mantecón Movellán


    Full Text Available Historical thought has tended to explain social disciplining according to two main analytical perspectives: on one hand, German tradition about the so-called sozialdisziplinierung and, on the other hand, Foucault perspectives (focussed on disciplines practiced on the bodies-and/or-minds of people by the authorities. From these both viewpoints social disciplining was a dynamic ingredient of change, from traditional societies up to contemporary liberal societies; a machinery to provoke top-down changes (from above. On the bases of historical evidences, this research claims for a third viewpoint that stresses dynamics of social discipline and social disciplining from below; underlines the need of integrating this third perspective in the historical explanation of change in past societies throughout the analysis of social practices of everyday life; the values underneath them and, in the end, taking into account varieties of discipline and perspectives of social disciplining from below.

  11. The Principalship in Historical Perspective (United States)

    Kafka, Judith


    This article offers a review of the existing historiography of the American school principal. Although a small and incomplete body of research, scholarship on the history of the principalship demonstrates that it has always been a complex and multifaceted role and that principals have historically drawn on shifting sources of authority to assert…

  12. Japan 2006 in historical perspectives

    Directory of Open Access Journals (Sweden)

    Michiko Tanaka Nishishima


    Full Text Available Readings of the current Japanese politics with the historic and social insight through analysis of four facts registered in 2006: the visit of the prime minister Koizumi to the Yasukuni shrine; the election of Abe Shinzo as the president of Liberal Democratic Party and the formation of Abe cabinet; the Atomic bomb experimentation by the North Corea; the publication of the book of feminist counteroffensive against the numerous rightist conservative harassment.

  13. Japan 2006 in historical perspectives


    Michiko Tanaka Nishishima


    Readings of the current Japanese politics with the historic and social insight through analysis of four facts registered in 2006: the visit of the prime minister Koizumi to the Yasukuni shrine; the election of Abe Shinzo as the president of Liberal Democratic Party and the formation of Abe cabinet; the Atomic bomb experimentation by the North Corea; the publication of the book of feminist counteroffensive against the numerous rightist conservative harassment.

  14. Hormesis: a fundamental concept in biology (United States)

    Calabrese, Edward J.


    This paper assesses the hormesis dose response concept, including its historical foundations, frequency, generality, quantitative features, mechanistic basis and biomedical, pharmaceutical and environmental health implications. The hormetic dose response is highly generalizable, being independent of biology model (i.e. common from plants to humans), level of biological organization (i.e. cell, organ and organism), endpoint, inducing agent and mechanism, providing the first general and quantitative description of plasticity. The hormetic dose response describes the limits to which integrative endpoints (e.g. cell proliferation, cell migration, growth patterns, tissue repair, aging processes, complex behaviors such as anxiety, learning, memory, and stress, preconditioning responses, and numerous adaptive responses) can be modulated (i.e., enhanced or diminished) by pharmaceutical, chemical and physical means. Thus, the hormesis concept is a fundamental concept in biology with a wide range of biological implications and biomedical applications.

  15. Hormesis: a fundamental concept in biology

    Directory of Open Access Journals (Sweden)

    Edward J. Calabrese


    Full Text Available This paper assesses the hormesis dose response concept, including its historical foundations, frequency, generality, quantitative features, mechanistic basis and biomedical, pharmaceutical and environmental health implications. The hormetic dose response is highly generalizable, being independent of biology model (i.e. common from plants to humans, level of biological organization (i.e. cell, organ and organism, endpoint, inducing agent and mechanism, providing the first general and quantitative description of plasticity. The hormetic dose response describes the limits to which integrative endpoints (e.g. cell proliferation, cell migration, growth patterns, tissue repair, aging processes, complex behaviors such as anxiety, learning, memory, and stress, preconditioning responses, and numerous adaptive responses can be modulated (i.e., enhanced or diminished by pharmaceutical, chemical and physical means. Thus, the hormesis concept is a fundamental concept in biology with a wide range of biological implications and biomedical applications.

  16. Active Learning: Historical and Contemporary Perspectives. (United States)

    Page, Marilyn

    The purposes of the first two parts of this literature review are to clarify the concept of active learning and discuss the use and value of active learning models. In Part I, the perspectives of five historical proponents of active learning, Rousseau, Pestalozzi, Dewey, Kilpatrick, and Piaget, are discussed. The views of four contemporary…

  17. Historical perspective: surgery for chronic thromboembolic disease. (United States)

    Jamieson, Stuart W


    This article provides a historical perspective for our current understanding of chronic thromboembolic pulmonary hypertension and surgery for this disease. It chronicles the developments in surgical techniques that have made pulmonary endarterectomy the procedure of choice for obstruction of pulmonary vessels by organized thromboemboli and secondary vessel wall thickening.

  18. Radiation hormesis in plant

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jae Sung; Song, Hi Sup; Lee, Young Keun; Cun, Ki Jung; Shin, In Chul; Lim, Young Taek


    This research was performed to investigate the effects of low dose {gamma}-ray radiation on the seed germination and the following physiological responses in vegetable crops. Special attention was focused on whether the resistance of vegetables against the unfavorable conditions of environment such as acid rain or soil types could be enhanced as an aspect of radiation hormesis. Analysis and characterization of antioxidant enzyme from plant culture cells and radiation tolerant of transformed plants from antioxidant enzyme (POD) were accomplished in the plant irradiated with difference dosage of {gamma}-ray.

  19. Radiation hormesis in plant

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jae Sung; Song, Hi Sup; Lee, Young Keun; Lee, Byung Hun; Shin, In Chul; Lim, Young Taek


    This research was performed to investigate the effects of low dose {gamma}-ray radiation on the seed germination and the following physiological responses in vegetable crops. Special attention was focused on whether the resistance of vegetables against the unfavorable conditions of environment such as subsequent high doses of radiation or Phytophthora blight of pepper could be enhanced as an aspect of radiation hormesis. Analysis and characterization of antioxidant enzyme from plant culture cells and radiation tolerant of transformed plants from antioxidant (POD) were accomplished in the plant irradiated with different dose of {gamma}-ray. (author)

  20. Radiation hormesis in higher plants

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jae Sung [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)


    The most remarkable aspect in the hormesis law is that low dose of harmful agents can produce effect that are diametrically opposite to the effect found with high doses of the same agent. Minute quantities of a harmful agent bring about very small change in the organism and control mechanisms appear to subjugate normal processes to place the organism in a state of alert and repair. The stimulated organism is more responsive to changes in environmental factors than it did before being alerted. Routine functions, including repair and defense, have priority for available energy and material. The alerted organism utilizes nutrients more efficiently, grows faster, shows improved defense reactions, matures faster, reproduces more effectively, has less disease, and lives longer. Accelerated germination, sprouting, growth, development, blooming and ripening, and increased crop yield and resistance to disease are found in plants. Another concept supported by the data is that low doses of ionizing radiation provide increased resistance to subsequent high doses of radiation. The hormesis varies with subject plant, variety, state of seed, environmental and cultural conditions, physiologic function measured, dose rate and total exposure. The results of hormesis are less consistently found, probably due to the great number of uncontrolled variables in the experiments. The general dosage for radiation hormesis in about 100 times ambient or 100 times less than a definitely harmful dose, but these must be modified to the occasion. Although little is known about most mechanisms of hormesis reaction, overcompensation of repair mechanism is offered as on mechanism. Radiation hormesis can provide more efficient use of resources, maximum production of foods, and increased health by the use of ionizing radiation as a useful tool in our technologic society. Efficient utilization of nature`s resources demands support to explore the practical application of radiation hormesis.

  1. DPAL: historical perspective and summary of achievements (United States)

    Zhdanov, B. V.; Knize, R. J.


    Alkali vapor lasers are under extensive research and development during the past decade because of their potential for scaling to high powers while maintaining a good beam quality. Also, a possibility of using efficient diode lasers for pumping alkali vapor promises high total wall plug efficiency for a Diode Pumped Alkali Laser (DPAL). Since the first DPAL demonstration with output power of 130 mW in 20051, a significant progress in this field was achieved. The output power of about 1 kW in continuous wave (CW) operation with optical efficiency close to 50% was recently demonstrated for a Cs DPAL2. Also, the DPALs based on other alkali metals (Rubidium and Potassium) were demonstrated3,4 . In spite of these significant achievements, there are still several problems in DPAL power scaling exist that must be addressed. Among them are the thermal5 and photoionization6 issues that become important even at power level about several tens of watts. In this paper we present a historical review of the alkali laser research and development, discuss the most important achievements and future perspectives in this field of research.

  2. Technical writing in America: A historical perspective (United States)

    Connaughton, M. E.


    The standard distinction between poetic and referential language, the gulf between science and the humanities, and the distress many teachers of English feel when faced for the first time with the prospect of teaching technical writing are discussed. In the introduction of many technical writing textbooks. Technical communication is divorced from other forms of linguistic experience by making language limiting and reductive rather than creative and expansive. The emphasis on technical/scientific writing as radically different had blinded people to those traits it has in common with all species of composition and has led to a neglect of research, on fundamental rhetorical issues. A complete rhetorical theory of technical discourse should include information about the attitudes and motives of writers, the situations which motivate (or coerce) them to write, definitive features of technical style and form, interrelationship of expression and creativity, and functions of communication in shaping and preserving scientific networds and institutions. The previous areas should be explored with respect to contemporary practice and within an historical perspective.

  3. Concerns for the Historical Profession: A Liberal Perspective. (United States)

    Jarausch, Konrad H.

    This paper contends that the debate over multiculturalism in the university is best understood from a broadened historical perspective. The experiences of educational reformers in Germany and the impact of fascism and communism are explored. Based on a historical approach to the multiculturalism debate, three areas of particular concern are…

  4. Perspectives: Using Historical Documents To Think about NIF Issues. (United States)

    National Archives and Records Service (GSA), Washington, DC.

    The purpose of using historical documents in the classroom is to generate and enhance discussion by providing a historical perspective for issues. Five documents are included in this packet and are to be used as a supplemental material for the National Issues Forum (NIF) topics. Issues raised include (1) an analysis of the documents and (2)…

  5. Historical Perspectives in Marketing Education: Justification and Implementation (United States)

    Petkus, Ed, Jr.


    This article provides a justification and an implementation plan for the establishment of a historical orientation across the undergraduate marketing curriculum. The justification for the historical perspective addresses three areas: tapping into the extensive body of knowledge in marketing history, practical implications, and critical thinking.…

  6. The hormesis concept and risk assessment: are there unique ethical and policy considerations? (United States)

    Hoffmann, Gr; Stempsey, We


    The hormesis concept holds that low doses of toxic substances and radiation elicit modest biological responses opposite to those caused by higher doses of the same agents. This concept stands in contrast to the prevailing views that a threshold model predicts most responses to toxicants at low doses and that linear extrapolation best predicts mutagenic and carcinogenic responses. Beyond the scientific considerations, there has been concern that inclusion of the hormesis model in risk assessment would raise complex ethical questions, pose serious challenges for policy makers, and threaten public safety. This article briefly reviews the growing evidence for hormesis and offers a perspective on the related ethical and societal issues. Complexities stem from the nature of biphasic curves, in which biological responses fall both above and below background levels. The monotonic responses of the threshold and linear models lend themselves to a single policy objective--avoiding harm associated with exposures. The biphasic responses of the hormesis model, however, suggest the possibility of accruing benefit as well as avoiding harm. The prospect of applying the hormesis model to public health policy is impeded by insufficient ability to identify the hormetic and toxic zones with precision. Moreover, heterogeneity among individuals in susceptibility to toxicants suggests that benefit and risk may be distributed unequally in the population. The potential shift in policy objectives associated with hormesis is considered relative to the difficulty of balancing the ethical principles of nonmaleficence and beneficence while maintaining a higher priority on the former.

  7. Global Transfer and Indian Management A Historical Hybridity Perspective

    NARCIS (Netherlands)

    Becker-Ritterspach, Florian; Raaijman, Tico


    The goal of this paper is to contribute to a better understanding of Indian management and to challenge more generally ahistorical and essentialist notions of indigenous management perspectives. Drawing selectively on postcolonial theory, we suggest that a historical hybridity perspective serves as

  8. An Historical Perspective on Collaborative Learning. (United States)

    Gaillet, Lynee Lewis


    Presents a historical study of the contribution of George Jardine to the field of composition. Considers why Jardine has been omitted from histories of writing instruction. Outlines Jardine's plan for using collaborative learning and peer editing in the classroom. (HB)

  9. [Scientific standards in parasitology in historical perspective]. (United States)

    Lonc, Elzbieta; Płonka-Syroka, Bozena


    An analysis of scientific standards in parasitology was carried out from the perspective of anthropology of knowledge - a new discipline that emerged from non-classical history science in the 1990s. The history of parasitology, its development and limitations, are presented in a broad socio-cultural context, as the answers of scientists to different social needs in historical periods. In parasitological history there are some periods characteristic for all newly emerging disciplines of natural science. The first systematic account of natural phenomena and their interpretations was initiated in the 16th century and continued till the mid 18th century. It was a period when the phenomena could not be explained in a proper way by the existing and accepted theories. The epidemic diseases were one of these phenomena which were interpreted based on ancient ideas, mostly humoral pathology. In the 16th century a new contagium concept of material factors (pathogenes) that could be spread by contact among humans or close association was formed. This hypothesis, however, was not widely accepted because it contradicted the well-established normative concepts in the European academic naturalism. The development of parasitology was stopped because of theoretical barriers and interpretation difficulties (non-materialistic standard of naturalism, humoral pathology and spontaneous theory). In the second half of the 18th century, the theoretical crisis in natural sciences gave a new impulse for many disciplines; among others, parasitology entered in its second stage of development. The collected observations were classified in a new way and in the context of new interpretations. The progress in parasitology was prompted by the intensified urbanization, rapid increase of European population as well as by wars connected with infections and epidemics. It resulted in two competitive research programs (the French and the German). On the basis of the same observations, they advanced

  10. The concept of learning in cultural-historical perspective

    DEFF Research Database (Denmark)

    Chaiklin, Seth


    A cultural-historical perspective on learning is presented. The key idea is to conceptualise learning as self-mastery of action, using existing psychological functions. The main part of the chapter provides an overview of Vygotsky’s theory of higher psychological functions, and discusses their im......A cultural-historical perspective on learning is presented. The key idea is to conceptualise learning as self-mastery of action, using existing psychological functions. The main part of the chapter provides an overview of Vygotsky’s theory of higher psychological functions, and discusses...

  11. Introduction: Communicating European Integration: A Historical Perspective

    Directory of Open Access Journals (Sweden)

    Manuel Müller


    Full Text Available Since the 1990s the so-called 'democratic deficit' of the EU became an increasingly discussed topic in both academic and political circles. In this context, the (apparently insufficient communication of European politics to its citizens has been of especially great importance. Academic research has invested considerable efforts in trying to analyse and explain these problematic relationships. However, because this still growing area of research is still dominated by social scientists, historical approaches seem to be somewhat underrepresented. Against this background, this special issue will present historical studies on actors, means and contents of communicating the process of European integration from its beginnings to the present day.

  12. Tales of two similar hypotheses: the rise and fall of chemical and radiation hormesis. (United States)

    Calabrese, E J; Baldwin, L A


    This paper compares the historical developments of chemical and radiation hormesis from their respective inceptions in the late 1880's for chemical hormesis and early 1900's for radiation hormesis to the mid 1930's to 1940 during which both hypotheses rose to some prominence but then became marginalized within the scientific community. This analysis documents that there were marked differences in their respective temporal developments, and the direction and maturity of research. In general, the formulation of the chemical hormesis hypothesis displayed an earlier, more-extensive and more sophisticated development than the radiation hormesis hypothesis. It was able to attract prestigious researchers with international reputations from leading institutions, to be the subject of numerous dissertations, to have its findings published in leading journals, and to have its concepts incorporated into leading microbiological texts. While both areas became the object of criticism from leading scientists, the intensity of the challenge was greatest for chemical hormesis due to its more visible association with the medical practice of homeopathy. Despite the presence of legitimate and flawed criticism, the most significant limitations of both chemical and radiation hormesis and their respective ultimate undoing were due to their: (1) lack of development of a coherent dose-response theory using data of low dose stimulation from both the chemical and radiation domains; (2) difficulty in replication of low dose stimulatory responses without an adequate study design especially with respect to an appropriate number and properly spaced doses below the toxic threshold; (3) modest degree of stimulation even under optimal conditions which was difficult to distinguish from normal variation; and (4) lack of appreciation of the practical and/or commercial applications of the concepts of low dose stimulation.

  13. Robotic Autonomous Observatories: A Historical Perspective


    Alberto Javier Castro-Tirado


    This paper presents a historical introduction to the field of Robotic Astronomy, from the point of view of a scientist working in this field for more than a decade. The author discusses the basic definitions, the differing telescope control operating systems, observatory managers, as well as a few current scientific applications.

  14. A historical perspective on space station (United States)

    Hook, W. Ray


    The historical development of space stations is presented through a series of various spacecraft configurations including: (1) Salut 6; (2) Skylab; (3) the Space Operations Center (SOC); (4) the Manned Science and Applications Space Platform; (5) Space Station Freedom; and (4) the Mir Space Station.

  15. Teaching Historical Memories in an Intercultural Perspective

    DEFF Research Database (Denmark)

    Scheibel, Katrine Vinther; Wrochem, Oliver

    How can we approach historical remembrance in history teaching? This question lies at the heart of the three-year, EU-funded project TeacMem,which involves partners from Denmark, Germany and Norway. The participants (teacher trainers, historians, teachers, memorial educators, disseminators...

  16. Robotic Autonomous Observatories: A Historical Perspective

    Directory of Open Access Journals (Sweden)

    Alberto Javier Castro-Tirado


    Full Text Available This paper presents a historical introduction to the field of Robotic Astronomy, from the point of view of a scientist working in this field for more than a decade. The author discusses the basic definitions, the differing telescope control operating systems, observatory managers, as well as a few current scientific applications.

  17. Putting Barack Obama's Candidacy in Historical Perspective (United States)

    Rogers, Ibram


    Senator Barack Obama's historic candidacy for president of the United States has generated an intense and thoughtful national discussion within Black America. His campaign has brought several issues to the fore. Recently, the author spoke with five of the most preeminent Black scholars in the nation to search out some of their thoughts on five key…

  18. Contemporary Social Psychology in Historical Perspective. (United States)

    Cartwright, Dorwin


    The current state of social psychology is assessed in light of its historical and social context. The discipline is viewed as a social system, and it is argued that the properties of this system have influenced the research techniques, substantive content, and theories of contemporary social psychology. (Author/RD)

  19. Social Justice: An Historical and Philosophical Perspective (United States)

    Stoll, Sharon Kay


    Social justice in education concerns three questions: whom do we teach, what do we teach, and how do we teach? In this article the author briefly discusses social justice and its related concepts, its historical underpinnings, the social climate that brought about social change, and its effect on teaching physical activity. She also gives personal…

  20. Risk and Risk society in Historical Perspective



    International audience; Since the mid-1980s “risk” has constituted a sort of banner to which the social sciences have rallied. It has given rise to a whole range of research in the political science, sociology and economics spheres. This paper is a general introduction to a History and Technology special issue which attempt to construct analytical frameworks and research proposals that may contribute to a historization and a denaturalization of risk. This paper considers the role of history i...

  1. The Voting Rights Act--An Historical Perspective (United States)

    Rustin, Bayard; And Others


    This address to the morning session of the Southern Policy Conference on the Voting Rights Act of 1965 puts the Act in an historical perspective in which its importance is clearly perceived; also includes is a discussion of the address by Nicholas Katzenbach, Vernon Jordan, James P. Turner, and George H. Esser, persons who either were involved in…

  2. Learning Spiritual Dimensions of Care from a Historical Perspective. (United States)

    Narayanasamy, Aru


    Looks at the spiritual dimensions of nursing at various historical periods: ancient civilizations, the Middle Ages, Renaissance, and the 18th and 19th centuries. Reviews contemporary perspectives on spirituality and nursing and suggests how nurses can be equipped to deal with patients' spiritual needs. (SK)

  3. Some economic historic perspectives on the 2009 world trade collapse

    NARCIS (Netherlands)

    P.A.G. van Bergeijk (Peter)


    textabstractThe paper puts the collapse of the world trade volume in 2009 into two historic perspectives. First, the paper analyses 18 major post-1980 / pre-2007 financial crises and uses these observations as a basis to critically evaluate presently available projections for world trade. Second, th

  4. Some economic historic perspectives on the 2009 world trade collapse

    NARCIS (Netherlands)

    P.A.G. van Bergeijk (Peter)


    textabstractThe paper puts the collapse of the world trade volume in 2009 into two historic perspectives. First, the paper analyses 18 major post-1980/pre-2007 financial crises and uses these observations as a basis to critically evaluate presently available projections for world trade. Second, the

  5. Historical perspectives on theories of periodontal disease etiology

    DEFF Research Database (Denmark)

    Hujoel, Philippe; Zina, Lívia Guimarães; Cunha-Cruz, Joana


    Our understanding of the causes of periodontal disease have changed greatly over time. The aim of this review is to provide a critical and historical perspective, dating back over more than a century, on two competing paradigms. While we understand that this stark dichotomization may be viewed...

  6. The Intelligence Revolution: A Historical Perspective (United States)


    Castro Hidalgo, Orlando. Spy for Fidel. Miami, FL: E. A. Seemann Pub., 1971. (JL 1009.5 .16 C3) Chomsky , Noam . The Washington connection and Third World...and Joseph 0. Baylen. Colonel Philip R. Faymonville and the Red Army, 1934-43. Slavic Review 35(3):483-505, 1975. Mersky, Peter. My dad made models . U.S...Neilson, Keith. "Joy rides?": British intelligence and propaganda in Russia, 1914-1917. Historical Journal 24(4):885-906, 1981. Watching the "steamroller

  7. People Recognition: A Historical/Anthropological Perspective

    Directory of Open Access Journals (Sweden)

    A. Ardila


    Full Text Available Using current neurological and neuropsychological literature, and the analysis of different cultural and historical conditions, people recognition is analyzed. Different “subsystems” or “modules” could be involved in individuals' recognition: living versus non-living, own species versus other species, familiar versus non-familiar, males versus females, and individual identification versus emotional identification. Not only visual, but also auditory and even olfactory information may be involved in people recognition. Visual information involved in people recognition is proposed to include not only the perception of faces, but also the perception of whole body and gait, clothes, emotional expressions, and individual marks.

  8. Geomagnetic storms: historical perspective to modern view (United States)

    Lakhina, Gurbax S.; Tsurutani, Bruce T.


    The history of geomagnetism is more than 400 years old. Geomagnetic storms as we know them were discovered about 210 years ago. There has been keen interest in understanding Sun-Earth connection events, such as solar flares, CMEs, and concomitant magnetic storms in recent times. Magnetic storms are the most important component of space weather effects on Earth. We give an overview of the historical aspects of geomagnetic storms and the progress made during the past two centuries. Super magnetic storms can cause life-threatening power outages and satellite damage, communication failures and navigational problems. The data for such super magnetic storms that occurred in the last 50 years during the space era is sparce. Research on historical geomagnetic storms can help to create a database for intense and super magnetic storms. New knowledge of interplanetary and solar causes of magnetic storms gained from spaceage observations will be used to review the super magnetic storm of September 1-2, 1859. We discuss the occurrence probability of such super magnetic storms, and the maximum possible intensity for the effects of a perfect ICME: extreme super magnetic storm, extreme magnetospheric compression, and extreme magnetospheric electric fields.

  9. Modeling Concept Evolution: A Historical Perspective (United States)

    Rizzolo, Flavio; Velegrakis, Yannis; Mylopoulos, John; Bykau, Siarhei

    The world is changing, and so must the data that describes its history. Not surprisingly, considerable research effort has been spent in Databases along this direction, covering topics such as temporal models and schema evolution. A topic that has not received much attention, however, is that of concept evolution. For example, Germany (instance-level concept) has evolved several times in the last century as it went through different governance structures, then split into two national entities that eventually joined again. Likewise, a caterpillar is transformed into a butterfly, while a mother becomes two (maternally-related) entities. As well, the concept of Whale (a class-level concept) changed over the past two centuries thanks to scientific discoveries that led to a better understanding of what the concept entails. In this work, we present a formal framework for modeling, querying and managing such evolution. In particular, we describe how to model the evolution of a concept, and how this modeling can be used to answer historical queries of the form "How has concept X evolved over period Y". Our proposal extends an RDF-like model with temporal features and evolution operators. Then we provide a query language that exploits these extensions and supports historical queries.

  10. The population health approach in historical perspective. (United States)

    Szreter, Simon


    The origin of the population health approach is an historic debate over the relationship between economic growth and human health. In Britain and France, the Industrial Revolution disrupted population health and stimulated pioneering epidemiological studies, informing the early preventive public health movement. A century-long process of political adjustment between the forces of liberal democracy and propertied interests ensued. The 20th-century welfare states resulted as complex political mechanisms for converting economic growth into enhanced population health. However, the rise of a "neoliberal" agenda, denigrating the role of government, has once again brought to the fore the importance of prevention and a population health approach to map and publicize the health impacts of this new phase of "global" economic growth.

  11. Astronomy in India a historical perspective

    CERN Document Server


    India has a strong and ancient tradition of astronomy, which seamlessly merges with the current activities in Astronomy and Astrophysics in the country. While the younger generation of astronomers and students are reasonably familiar with the current facilities and the astronomical research, they might not have an equally good knowledge of the rich history of Indian astronomy. This particular volume, brought out as a part of the Platinum Jubilee Celebrations of Indian National Science Academy, concentrates on selected aspects of historical development of Indian astronomy in the form of six invited chapters. Two of the chapters – by Balachandra Rao and M.S. Sriram – cover ancient astronomy and the development of calculus in the ancient Kerela text Yuktibhasa. The other four chapters by B.V. Sreekantan, Siraj Hasan, Govind Swarup and Jayant Narlikar deal with the contemporary history of Indian astronomy covering space astronomy, optical astronomy, radio astronomy and developments in relativistic astrophysic...

  12. The vector algebra war: A historical perspective

    CERN Document Server

    Chappell, James M; Hartnett, John G; Abbott, Derek


    There are a wide variety of different vector formalisms currently utilized in science. For example, Gibbs three-vectors, spacetime four-vectors, complex spinors for quantum mechanics, quaternions used for rigid body rotations and Clifford multivectors. With such a range of vector formalisms in use, it thus appears that there is as yet no general agreement on a vector formalism suitable for the whole of science. This surprising situation exists today, despite the fact that one of the main goals of nineteenth century science was to correctly describe vectors and the algebra of three-dimensional space. This situation has also had the unfortunate consequence of fragmenting knowledge across many disciplines and requiring a very significant amount of time and effort in learning the different formalisms. We thus review historically the development of our various vector systems and conclude that the Clifford algebra multivector fulfills the goal of correctly describing vectorial quantities in three dimensions.

  13. Optimal experimental design strategies for detecting hormesis



    Hormesis is a widely observed phenomenon in many branches of life sciences ranging from toxicology studies to agronomy with obvious public health and risk assessment implications. We address optimal experimental design strategies for determining the presence of hormesis in a controlled environment using the recently proposed Hunt-Bowman model. We propose alternative models that have an implicit hormetic threshold, discuss their advantages over current models, construct and study properties of...

  14. Poverty, Population, Inequality, and Development: the Historical Perspective

    Directory of Open Access Journals (Sweden)

    Chilosi, Alberto


    Full Text Available Seen in historical perspective the main economic predicaments of the present world (such as poverty, inequality, backwardness appear in a somewhat different light than in many current discussions, especially by sociologists, radical economists and political scientists. In the present paper the achievements of the modern age, and in particular of the post- World War II period, are considered in the perspective of economic and demographic history, and in their connection with the systems of production and of international relations. Some considerations concerning future possible developments conclude the paper.

  15. Science and technology from global and historical perspectives

    CERN Document Server

    Karagözoğlu, Bahattin


    This book provides science and technology ethos to a literate person. It starts with a rather detailed treatment of basic concepts in human values, educational status and domains of education, development of science and technology and their contributions to the welfare of society. It describes ways and means of scientific progresses and technological advancements with their historical perspectives including scientific viewpoints of contributing scientists and technologists. The technical, social, and cultural dimensions are surveyed in relation to acquisition and application of science, and advantages and hindrances of technological developments. Science and Technology is currently taught as a college course in many universities with the intention to introduce topics from a global historical perspective so that the reader shall stretch his/her vision by mapping the past to the future. The book can also serve as a primary reference for such courses.

  16. Historical perspective on developmental concepts and terminology. (United States)

    Opitz, John M; Neri, Giovanni


    In their ontogeny and phylogeny all living beings are historical entities. The revolution in biology of the 18th and 19th centuries that did away with the scala naturae according to which we humans, the acme of creation, "made a little lower than the angels," also led to the gradual realization that a humble one-celled protist ("protoctist"), such as Entamoeba histolytica of ill repute [Margulis and Chapman, ] has the same 4-billion-year phylogeny as that of Homo sapiens, vivid testimony to common ancestry and the relatedness of all living beings on earth. The group of medical geneticists who assembled at the NIH, Bethesda, MD this January to address terms pertaining to human ontogeny, did so in the long tradition of Sydenham, Linnaeus, Meckel, Geoffroy St-Hilaire père et fils, Wilhelm His and so many others before who had over the previous two centuries wrestled as earnestly as they could with concepts of "classification" and nomenclature of developmental anomalies. The prior massive need for classification per se in medical morphology has diminished over the years in favor of ever more sophisticated understanding of pathogenesis and cause through experimental biology and genetics; however, in the winter of 2013 it was still found prudent to respect terminological precedent on general terms while recognizing recent advances in developmental pathology requiring clarification and definition of special terms. Efforts along similar lines instigated by the German Society of Anatomists at their first meeting in Leipzig in 1887 culminated, after intense years of work by hundreds of experts and consultants under the goad of Wilhelm His, in the Basel Nomina Anatomica [BNA, His (1895)]. His, himself, stated prefatorily that the BNA had no legislative weight, only an evanescent consensus of many to be amended in the future as needed and indicated. Without hubris, no one before or after will do the same. The more substantial the consensus the more permanent the structure

  17. Plant taxonomy: a historical perspective, current challenges, and perspectives. (United States)

    Rouhan, Germinal; Gaudeul, Myriam


    Taxonomy is the science that explores, describes, names, and classifies all organisms. In this introductory chapter, we highlight the major historical steps in the elaboration of this science that provides baseline data for all fields of biology and plays a vital role for society but is also an independent, complex, and sound hypothesis-driven scientific discipline.In a first part, we underline that plant taxonomy is one of the earliest scientific disciplines that emerged thousands of years ago, even before the important contributions of Greeks and Romans (e.g., Theophrastus, Pliny the Elder, and Dioscorides). In the fifteenth to sixteenth centuries, plant taxonomy benefited from the Great Navigations, the invention of the printing press, the creation of botanic gardens, and the use of the drying technique to preserve plant specimens. In parallel with the growing body of morpho-anatomical data, subsequent major steps in the history of plant taxonomy include the emergence of the concept of natural classification, the adoption of the binomial naming system (with the major role of Linnaeus) and other universal rules for the naming of plants, the formulation of the principle of subordination of characters, and the advent of the evolutionary thought. More recently, the cladistic theory (initiated by Hennig) and the rapid advances in DNA technologies allowed to infer phylogenies and to propose true natural, genealogy-based classifications.In a second part, we put the emphasis on the challenges that plant taxonomy faces nowadays. The still very incomplete taxonomic knowledge of the worldwide flora (the so-called taxonomic impediment) is seriously hampering conservation efforts that are especially crucial as biodiversity enters its sixth extinction crisis. It appears mainly due to insufficient funding, lack of taxonomic expertise, and lack of communication and coordination. We then review recent initiatives to overcome these limitations and to anticipate how taxonomy

  18. Optimal experimental design strategies for detecting hormesis. (United States)

    Dette, Holger; Pepelyshev, Andrey; Wong, Weng Kee


    Hormesis is a widely observed phenomenon in many branches of life sciences, ranging from toxicology studies to agronomy, with obvious public health and risk assessment implications. We address optimal experimental design strategies for determining the presence of hormesis in a controlled environment using the recently proposed Hunt-Bowman model. We propose alternative models that have an implicit hormetic threshold, discuss their advantages over current models, and construct and study properties of optimal designs for (i) estimating model parameters, (ii) estimating the threshold dose, and (iii) testing for the presence of hormesis. We also determine maximin optimal designs that maximize the minimum of the design efficiencies when we have multiple design criteria or there is model uncertainty where we have a few plausible models of interest. We apply these optimal design strategies to a teratology study and show that the proposed designs outperform the implemented design by a wide margin for many situations.

  19. Unequal brothers : are homeopathy and hormesis linked? (United States)

    Oberbaum, Menachem; Frass, Michael; Gropp, Cornelius


    The debate between those who believe homeopathy and hormesis derive from the same root and those who believe the two are different phenomena is as old as hormesis. It is an emotionally loaded discussion, with both sides fielding arguments which are far from scientific. Careful analysis of the basic paradigms of the two systems questions the claim of the homeopaths, who find similarities between them. The authors discuss these paradigms, indicating the differences between the claims of homeopathy and hormesis. It is time for thorough and serious research to lay this question to rest. One possible approach is to compare the activity of a hormetic agent, prepared in the usual way, with that of the same agent in the same concentration prepared homeopathically by serial dilution and succussion.

  20. Summer 2015 Extremes over South Asia within the Historical Perspective (United States)

    Rastogi, D.; Ashfaq, M.


    South Asian summer in 2015 has been marked by weather events of extremely different nature, including hot extremes over India and Pakistan, and wet extremes over northern, western and eastern states of India. Interestingly, these extremes are happening against the backdrop of warm sea surface temperature anomalies in the equatorial Pacific, which has historically reduced the strength of summer monsoon over South Asia. Given the occurrence of the contrasting anomalies at large and regional scales, in this study, we analyze 2015 extremes over South Asia within the historical perspective. We study the anomalies in the land, atmospheric and oceanic processes that potentially led to the regional heat waves and wet extremes throughout the summer and their connection to the large-scale anomalies in the monsoon dynamic. Additionally, we analyze historical simulations of the CMIP5 GCMs to investigate the likelihood of these anomalies with respect to the pre-industrial time period. Our analysis suggests evolving changes in the monsoon dynamics over South Asia where the lesser-known regional and local drivers have influence on the historical tele-connections.

  1. Historical perspective and advances in the treatment of multiple myeloma

    Directory of Open Access Journals (Sweden)

    Amir Harandi


    Full Text Available Corticosteroids and melphalan were used for decades to treat multiple myeloma. Combination chemotherapy has been extensively studied with similar overall survival rates to melphalan and prednisone. In the last decade, the development of new agents has progressed significantly. Thalidomide and its newer derivatives lenalidomide, bortezomib, and pegylated liposomal doxorubicin have drastically revolutionized treatment approaches. As a result, numerous clinical trials have yielded exciting treatment strategies resulting in therapeutic advances, and improved responses and overall survival of patients. This review summarizes the international uniform response criteria for multiple myeloma and gives a historical perspective on previous therapies with updates on the newest available treatments.

  2. Historic perspectives from anthropology. Reflections proposed to Transcultural Nursing. (United States)

    Rohrbach Viadas, Cecilia


    History brings together meanings related to earlier periods, being aware of the past as a panorama to reread the present. Madeleine Leininger presented in 1970 an implicit and respectful message to the Nursing Profession when introducing Nursing and Anthropology. Two Worlds to Blend. Implicitly: Nursing you disregard culture. This article shows the absence of the history of anthropology and of nursing within Transcultural Nursing and it includes how education has influenced theoretic, methodological, and comparative approaches giving researchers the responsibility to decide their fundamentals. Berthoud (2001) has inspired the anthropological and historic perspectives of the author, thus universalism, relativism, and comparison are presented.

  3. Separations chemistry for f elements: Recent developments and historical perspective

    Energy Technology Data Exchange (ETDEWEB)

    Nash, K.L. [Argonne National Lab., IL (United States); Choppin, G.R. [Florida State Univ., Tallahassee, FL (United States). Dept. of Chemistry


    With the end of the cold war, the principal mission in actinide separations has changed from production of plutonium to cleanup of the immense volume of moderately radioactive mixed wastes which resulted from fifty years of processing activities. In order to approach the cleanup task from a proper perspective, it is necessary to understand the nature of the problem and how the wastes were generated. In this report, the history of actinide separations, both the basic science and production aspects, is examined. Many of the separations techniques in use today were developed in the 40`s and 50`s for the identification and production of actinide elements. To respond to the modern world of actinide separations new techniques are being developed for separations ranging from analytical methods to detect ultra-trace concentrations (for bioassay and environmental monitoring) to large scale waste treatment procedures. Some of these new methods are ``improvements`` or adaptations of the historical techniques. Total actinide recovery, lanthanide/actinide separations, and selective partitioning of actinides from inert constituents are of primary concern. This report, offers a historical perspective, review the current status of f element separation processes, and suggest areas for continued research in both actinide separations and waste cleanup/environment remediation.

  4. Using Digital Primary Sources to Teach Historical Perspective to Preservice Teachers (United States)

    Waring, Scott M.; Torrez, Cheryl A. Franklin


    This article focuses on the use of digital primary sources to teach historical perspective to preservice teachers. Discussed here are the experiences of 90 elementary education majors during their inquiry-based elementary social studies methods course. A variety of digital primary sources were used to teach historical perspective and to model…


    Directory of Open Access Journals (Sweden)

    Moh. Fathoni


    Full Text Available New Historicism and cultural history have opened up the new approaches to writing histories. However, the last decade national and transnational literary histories have continued to take different approaches, by typical new national literary histories have distinguished the teleology of grand narratives by revised the linear ways into specific subjects and certain conception. In the following discussion, I shall describe how ‘new’ perspective of moral and ideological on history of literary criticism reacted to the crisis of history writing, by appearing the writing of the history of Islamic literary criticism—especially to perceiving the historical writing proposed by M.A.R. Habib, A History of Literary Criticism (2005.

  6. Statistical methods and applications from a historical perspective selected issues

    CERN Document Server

    Mignani, Stefania


    The book showcases a selection of peer-reviewed papers, the preliminary versions of which were presented at a conference held 11-13 June 2011 in Bologna and organized jointly by the Italian Statistical Society (SIS), the National Institute of Statistics (ISTAT) and the Bank of Italy. The theme of the conference was "Statistics in the 150 years of the Unification of Italy." The celebration of the anniversary of Italian unification provided the opportunity to examine and discuss the methodological aspects and applications from a historical perspective and both from a national and international point of view. The critical discussion on the issues of the past has made it possible to focus on recent advances, considering the studies of socio-economic and demographic changes in European countries.

  7. RACK(1) to the future - a historical perspective

    LENUS (Irish Health Repository)

    Ron, Dorit


    This perspective summarises the first and long overdue RACK1 meeting held at the University of Limerick, Ireland, May 2013, in which RACK1’s role in the immune system, the heart and the brain were discussed and its contribution to disease states such as cancer, cardiac hypertrophy and addiction were described. RACK1 is a scaffolding protein and a member of the WD repeat family of proteins. These proteins have a unique architectural assembly that facilitates protein anchoring and the stabilisation of protein activity. A large body of evidence is accumulating which is helping to define the versatile role of RACK1 in assembling and dismantling complex signaling pathways from the cell membrane to the nucleus in health and disease. In this commentary, we first provide a historical perspective on RACK1. We also address many of the pertinent and topical questions about this protein such as its role in transcription, epigenetics and translation, its cytoskeletal contribution and the merits of targeting RACK1 in disease.

  8. Crisis discussions in psychology--New historical and philosophical perspectives. (United States)

    Sturm, Thomas; Mülberger, Annette


    In this introductory article, we provide a historical and philosophical framework for studying crisis discussions in psychology. We first trace the various meanings of crisis talk outside and inside of the sciences. We then turn to Kuhn's concept of crisis, which is mainly an analyst's category referring to severe clashes between theory and data. His view has also dominated many discussions on the status of psychology: Can it be considered a "mature" science, or are we dealing here with a pre- or multi-paradigmatic discipline? Against these Kuhnian perspectives, we point out that especially, but not only in psychology distinctive crisis declarations and debates have taken place since at least the late 19th century. In these, quite different usages of crisis talk have emerged, which can be determined by looking at (a) the content and (b) the dimensions of the declarations, as well as (c) the functions these declarations had for their authors. Thus, in psychology at least, 'crisis' has been a vigorous actor's category, occasionally having actual effects on the future course of research. While such crisis declarations need not be taken at face value, they nevertheless help to break the spell of Kuhnian analyses of psychology's history. They should inform ways in which the history and philosophy of psychology is studied further.

  9. Epidemiological profile of India: Historical and contemporary perspectives

    Indian Academy of Sciences (India)

    M D Gupte; Vidya Ramachandran; R K Mutatkar


    Knowledge and understanding of the epidemiological profile is an essential pre-requisite to assess and address public health needs in the country and to enable efficient programme planning and management. The need for adequate and accurate health information and data to undertake such an exercise cannot be over-emphasized. The present effort is a modest attempt to critically analyse the epidemiological profile of India from the historical and contemporary perspective. In order to assess the successes achieved as well caution against the daunting challenges awaiting the country, parameters such as disease burden and health status indicators, are increasingly being used. Changes in the population age structure, improvements in the nation’s economic status, altered lifestyles of people and duality of disease burden testify to the demographic, development and health transition occurring in the country. Population stabilization, poverty alleviation, life-style modification, surveillance and control of communicable and non-communicable diseases constitute the major challenges demanding urgent attention in the future.

  10. Postnatal care: a cross-cultural and historical perspective. (United States)

    Eberhard-Gran, Malin; Garthus-Niegel, Susan; Garthus-Niegel, Kristian; Eskild, Anne


    Childbirth and the immediate postpartum period represent a major transition in a woman's life. This period is considered a vulnerable time for the mother and child in most societies, and rituals for this transition are common. In this study, we present some examples of postpartum customs in a cross-cultural and historical perspective. Also, we present the current knowledge on the possible impact of postnatal care on mental health. Systematic literature searches were performed in Medline, PsycINFO, and the Science Citation Index Expanded (ISI) for the time period 1966 through May 2010. Reference lists in books on pregnancy and childbirth from the University Library in Oslo were used to obtain additional information. We found that the postnatal period seems to be universally defined as 40 days. Most cultures have special postnatal customs, including special diet, isolation, rest, and assistance for the mother. The uniformity of customs across different cultures is striking. However, many postnatal customs that were common before 1950 are no longer existent. The focus on rest and assistance for the mother after delivery has gradually decreased. Studies of associations of postnatal care and mental health in the mother are limited and show inconsistent results. More knowledge is needed on postnatal care and mental health.

  11. Insecticide-induced hormesis and arthropod pest management. (United States)

    Guedes, Raul Narciso C; Cutler, G Christopher


    Ecological backlashes such as insecticide resistance, resurgence and secondary pest outbreaks are frequent problems associated with insecticide use against arthropod pest species. The last two have been particularly important in sparking interest in the phenomenon of insecticide-induced hormesis within entomology and acarology. Hormesis describes a biphasic dose-response relationship that is characterized by a reversal of response between low and high doses of a stressor (e.g. insecticides). Although the concept of insecticide-induced hormesis often does not receive sufficient attention, or has been subject to semantic confusion, it has been reported in many arthropod pest species and natural enemies, and has been linked to pest outbreaks and potential problems with insecticide resistance. The study of hormesis remains largely neglected in entomology and acarology. Here, we examined the concept of insecticide-induced hormesis in arthropods, its functional basis and potential fitness consequences, and its importance in arthropod pest management and other areas.

  12. Geohistorical Archaeology: A Perspective for Considering the Historic Past (United States)

    McGregor, John R.


    The term geohistorical archaeology was adopted to describe the combination of the techniques and concepts of historical geography, historical archaeology, and history. It is suggested that the field offers the potential of enhanced research and instruction as it pertains to the early historical settlement of an area. Particular emphasis is placed…

  13. Review of retrofit strategies decision system in historic perspective

    Directory of Open Access Journals (Sweden)

    M. D. Bostenaru Dan


    Full Text Available Urban development is a process. In structuring and developing its phases different actors are implied, who act under different, sometimes opposite, dynamic conditions and within different reference systems. This paper aims to explore the contribution of participatism to disaster mitigation, when this concerns earthquake impact on urban settlements, through the support provided to multi-criteria decision in matters of retrofit. The research broadness in field of decision making on one side and the lack of a specific model for the retrofit of existing buildings on another side led to an extensive review of the state of the art in related models to address the issue. Core idea in the selection of existing models has been the preoccupation for collaborative issues, in other words, the consideration for the different actors implied in the planning process. The historic perspective on participative planning models is made from the view of two generations of citizen implication. The first approaches focus on the participation of the building owner/inhabitant in the planning process of building construction. As current strategies building rehabilitation and selection from alternative retrofit strategies are presented. New developments include innovative models using the internet or spatial databases. The investigated participation approaches show, that participation and communication as a more comprehensive term are an old topic in the field politics-democratisation-urbanism. In all cases it can be talked of 'successful learning processes', of the improvement of the level of the professional debate. More than 30 years history of participation marked a transition in understanding the concept: from participation, based on a central decision process leading to a solution controlled and steered by the political-administrative system, to communication, characterised by simultaneous decision processes taking place outside politics and administration in co

  14. Hormesis and the salk polio vaccine. (United States)

    Calabrese, Edward J


    The production of the Salk vaccine polio virus by monkey kidney cells was generated using the synthetic tissue culture medium, Mixture 199. In this paper's retrospective assessment of this process, it was discovered that Mixture 199 was modified by the addition of ethanol to optimize animal cell survival based on experimentation that revealed a hormetic-like biphasic response relationship. This hormesis-based optimization procedure was then applied to all uses of Mixture 199 and modifications of it, including its application to the Salk polio vaccine during preliminary testing and in its subsequent major societal treatment programs.

  15. Parental Involvement and Participation in German Schools: Insights from Historical, Jurisdictional, and Empirical Perspectives (United States)

    Brauckmann, Stefan; Geißler, Gert; Weishaupt, Horst


    This article starts with a historical perspective on parental involvement in German schools' decision making in the context of historical developments and societal conditions as well as those specific to federal states. Subsequently, a presentation of contemporary school legislation highlights parental rights and duties with respect to parental…

  16. Greenhouse effect and ice ages: historical perspective; Effet de serre et glaciations, une perspective historique

    Energy Technology Data Exchange (ETDEWEB)

    Bard, E. [College de France, Chaire d' Evolution du Climat et de l' Ocean, 75 - Paris (France); CEREGE (UMR 6635), 13 - Aix en Provence (France)


    This article provides a brief historical perspective on the first scientific research on the greenhouse effect and glaciations. While these two aspects of our climate can be investigated separately, naturalists, physicists and chemists during the 19. century were interested jointly in both issues, as well as the possible relationship between them. The contributions of famous pioneers are mentioned, ranging from scholars with encyclopedic knowledge such as Horace-Benedict de Saussure, to modern scientists like Svante Arrhenius, who was first to predict global warming as a consequence of using fossil fuels. Despite fragmentary observations, these pioneers had prophetic insights. Indeed, the main fundamental concepts used nowadays have been developed during the 19. century. However, we must wait until the second half of the 20. century to see a true revolution of investigative techniques in the Earth Sciences, enabling full access to previously unknown components of the climate system, such as deep oceans and the interior of the polar ice caps. (author)

  17. Historical Perspectives on Games and Education from the Learning Sciences (United States)

    Shelton, Brett E.; Satwicz, Tom; Caswell, Tom


    This paper reviews three classic theorists' writing on games, learning, and development. Piaget, Vygotsky, and Bruner all wrote about games and play as important to thinking and learning. This review attempts to synthesize their perspectives as a means to revisit underused theoretical perspectives on the role of games in education. The views of…

  18. Testing elementary and secondary school students’ ability to perform historical perspective taking: the constructing of valid and reliable measure instruments

    NARCIS (Netherlands)

    Huijgen, Tim; van Boxtel, Carla; van de Grift, Wim; Holthuis, Paul


    Historical reasoning competencies play an important role in history education. However, valid and reliable large-scale measurement instruments to assess these competencies are scarce. This study considers two instruments for measuring students’ ability to perform historical perspective taking (HPT)

  19. Hormesis [Biological Effects of Low Level Exposures (Belle)] and Dermatology


    Thong, Haw-Yueh; Maibach, Howard I.


    Hormesis, or biological effects of low level exposures (BELLE), is characterized by nonmonotonic dose response which is biphasic, displaying opposite effects at low and high dose. Its occurrence has been documented across a broad range of biological models and diverse type of exposure. Since hormesis appears to be a relatively common phenomenon in many areas, the objective of this review is to explore its occurrence related to dermatology and its public health and risk assessment implication....

  20. Fundamental Flaws of Hormesis for Public Health Decisions


    Thayer, Kristina A.; Melnick, Ronald; Burns, Kathy; DAVIS, Devra; Huff, James


    Hormesis (defined operationally as low-dose stimulation, high-dose inhibition) is often used to promote the notion that while high-level exposures to toxic chemicals could be detrimental to human health, low-level exposures would be beneficial. Some proponents claim hormesis is an adaptive, generalizable phenomenon and argue that the default assumption for risk assessments should be that toxic chemicals induce stimulatory (i.e., “beneficial”) effects at low exposures. In many cases, nonmonoto...

  1. Healthy ageing - from molecules to hormesis

    DEFF Research Database (Denmark)

    Rattan, Suresh


    life style alterations are examples of ageing interventions. A promising healthy-ageing approach is that of hormesis by strengthening the homeodynamic ability of self-maintenance through transient and repetitive mild stress-inducing hormetins. Achieving the goal of extended health-span will depend......Ageing can be understood at various levels, from evolutionary and biological levels to psychological and sociological levels. At the molecular biological level ageing is characterized by the stochastic occurrence and progressive accumulation of molecular damage. Failure of homeodynamics, increased...... molecular heterogeneity, altered cellular functioning and reduced stress tolerance are the determinants of health status, probability of diseases and the duration of survival. The inefficiency and imperfection of the maintenance and repair systems underlie the biological basis of ageing. Two major issues...

  2. Molecular gerontology: from homeodynamics to hormesis. (United States)

    Rattan, Suresh I S


    The science and study of the biological basis of aging, biogerontology, is now a well-established field with solid scientific base. A paradigm-shift in gerontology has occurred by realising the fact that biological aging occurs in spite of the presence of complex homeodynamic pathways of maintenance, repair and defence, and there is no "enemy within". This viewpoint separates the modulation of aging from the treatment of one or more age-related diseases. A promising strategy in biogerontology is to slow down aging and to extend healthspan by hormetin-mediated hormesis. Physical, nutritional and mental hormetins, which initiate stress responses and strengthen the homeodynamics, are potentially effective aging modulators. As a biomedical issue, the biological process of aging underlies all major diseases, and while the optimal treatment of every disease is a social and moral necessity, preventing the onset of agerelated diseases by intervening in the basic process of aging is the best approach for designing novel pharmaceutical interventions.

  3. An Historical Perspective on Fractional Calculus in Linear Viscoelasticity

    CERN Document Server

    Mainardi, Francesco


    The article provides an historical survey of the early contributions on the applications of fractional calculus in linear viscoelasticty. The period under examination covers four decades, since 1930's up to 1970's and authors are from both Western and Eastern countries. References to more recent contributions may be found in the bibliography of a recent book by the author.

  4. Art as an investment in a historical perspective

    NARCIS (Netherlands)

    David, Geraldine


    This dissertation studies the price formation mechanisms on the art market. More specifically, it uses historical data to test the impact of several factors on the French art market between 1860 and 1950 and on the Belgian art market between 1945 and 1950. The first paper investigates the link betwe

  5. The Materiality of Digital Collections: Theoretical and Historical Perspectives (United States)

    Manoff, Marlene


    Digital and textual objects are coming under a new kind of scrutiny as scholars are becoming more interested in physical artifacts and their relation to their social and cultural environment. This study of material culture suggests a need to explore the nature of digital materiality, as well as the broader historical context in which electronic…

  6. Historical Perspectives in the Care of Patients with Enterocutaneous Fistula (United States)


    KEYWORDS: Enterocutaneous fistulas, historical review Objectives: On completion of this article the reader should understand the evolution of care of the...and proton-pump inhibitors can decrease fistula effluent, prevent stress- induced gastritis , and reduce electrolyte losses, but have not been

  7. Polynomial Approximation of Functions: Historical Perspective and New Tools (United States)

    Kidron, Ivy


    This paper examines the effect of applying symbolic computation and graphics to enhance students' ability to move from a visual interpretation of mathematical concepts to formal reasoning. The mathematics topics involved, Approximation and Interpolation, were taught according to their historical development, and the students tried to follow the…

  8. College Student Values: An Historical and Conceptual Perspective. (United States)

    Martin, William E.

    A historical survey of the literature and research on values and value measurement is presented. Various approaches to value study such as the Allport-Vernon-Lindsey model and the work of Adorno, et al in "The Authoritarian Personality" are discussed and analyzed. The author suggests that the models set forth in these works are not…

  9. Historic perspective: Prebiotics, probiotics, and other alternatives to antibiotics (United States)

    Antibiotic applications in agricultural and human medical arenas have resulted in tremendous increases in food animal production and historically unprecedented gains in human health protection. Successes attributed to wide-spread antibiotic use have been accompanied by the inadvertent emergence of r...

  10. The Aesthetic As Immediately Sensuous: An Historical Perspective (United States)

    Madenfort, Duke


    The views of Immanuel Kant, Soren Kierkegaard, Henri Bergson, John Dewey, and Susanne Langer were discussed. In this article they served as five important figures in a historical account of the concept of the aesthetic as the immediately sensuous. (Author/RK)

  11. Pirates, ports, and coasts in Asia: historical and contemporary perspectives

    NARCIS (Netherlands)

    Kleinen, J.; Osseweijer, M.


    Pirates, Ports and Coasts in Asia aims to fill in some of the historical gaps in the coverage of maritime piracy and armed robbery in Asia. The authors highlight a variety of activities ranging from raiding, destroying and pillaging coastal villages and capturing inhabitants to attacking and taking

  12. Researching Children's Musical Culture: Historical and Contemporary Perspectives (United States)

    McCarthy, M.


    When she was invited to present a keynote address at the Exeter Conference, the author was asked to offer "a particular perspective on a field of research within music education or a related domain". Given her interest in the related disciplines of sociology and ethnomusicology, and acknowledging the centrality of children's music making in the…

  13. The (de)Militarization of Humanitarian Aid: A Historical Perspective



    Humanitarian workers often complain that international aid to victims of armed conflicts is more and more militarized because relief organizations are embedded into peacekeeping operations, used as a "force multiplier", or manipulated as an instrument of diplomacy by proxy. Historically, however, charity has always been a military issue in times of war. We can distinguish four types of militarization of relief organizations in this regard. First is the use of charities to make "war by proxy",...

  14. Historical and current perspectives on Clostridium botulinum diversity. (United States)

    Smith, Theresa J; Hill, Karen K; Raphael, Brian H


    For nearly one hundred years, researchers have attempted to categorize botulinum neurotoxin-producing clostridia and the toxins that they produce according to biochemical characterizations, serological comparisons, and genetic analyses. Throughout this period the bacteria and their toxins have defied such attempts at categorization. Below is a description of both historic and current Clostridium botulinum strain and neurotoxin information that illustrates how each new finding has significantly added to the knowledge of the botulinum neurotoxin-containing clostridia and their diversity.

  15. A Medieval Perspective of Historical California and Nevada Droughts (United States)

    Hatchett, B.; Boyle, D. P.; Garner, C.; Putnam, A. E.; Bassett, S.; Kaplan, M.


    Dryland closed basin lake systems are ideal natural laboratories for model-proxy evaluations of how climate change alters the regional water balance. We use an existing water balance and lake-evaporation model of the Walker Lake Basin, a 1600-year reconstruction of Walker Lake shoreline elevations, and fields from the 20th Century Reanalysis to provide the following insights: 1) The three major historical (post-Little Ice Age) droughts observed in the California-western Nevada region (the 1930s, 1987-1992, and 2012-2015) are comparable in magnitude to the severe droughts of the Medieval Climate Anomaly but not in duration; 2) The atmospheric circulation anomalies associated with these events include poleward deflections of storm tracks and reduced moisture transport into the region; 3) To produce the Medieval lowstands of Walker Lake, precipitation and circulation anomalies comparable to historical droughts must persist for a minimum of 50 years. These insights show how severe historical and ongoing droughts in this region are within the range of natural variability. The 2012-2015 drought is also shown to be exacerbated by recent positive temperature anomalies that may be outside of the range of natural variability. These results can help to improve future water resource planning for the western United States, where ongoing and future changes in climate leading to increased water scarcity will have significant negative impacts on socioeconomic and ecological systems.

  16. Historical Perspectives and Recent Trends in the Coastal Mozambican Fishery

    Directory of Open Access Journals (Sweden)

    Jessica L. Blythe


    Full Text Available Historical data describing changing social-ecological interactions in marine systems can help guide small-scale fisheries management efforts. Fisheries landings data are often the primary source for historical reconstructions of fisheries; however, we argue that reliance on data of a single type and/or from a single scale can lead to potentially misleading conclusions. For example, a narrow focus on aggregate landings statistics can mask processes and trends occurring at local scales, as well as the complex social changes that result from and precipitate marine ecosystem change. Moreover, in the case of many small-scale fisheries, landings statistics are often incomplete and/or inaccurate. We draw on case study research in Mozambique that combines national landings statistics and career history interviews with fish harvesters to generate a multi-scale historical reconstruction that describes social-ecological interactions within the coastal Mozambican fishery. At the national level, our analysis points toward trends of fishing intensification and decline in targeted species, and it highlights the significant impact of small-scale fisheries on marine stocks. At the local level, fishers are experiencing changes in fish abundance and distribution, as well as in their physical, social, and cultural environments, and have responded by increasing their fishing effort. We conclude with a discussion of the governance implications of our methodological approach and findings.

  17. Causation and Caution in Financial Aid Reform: A Historical Perspective through Multiple Shades of Gray Literature (United States)

    Broomhead, Keiko Shimizu


    To better understand how a once well-intentioned concept of financial tuition assistance for college students has devolved into its current troubled and broken state, this doctoral thesis explored the evolution of the U.S. system of federal financial aid in higher education from a historical perspective. The study began with a review of the…

  18. Computer Science Education in French Secondary Schools: Historical and Didactical Perspectives (United States)

    Baron, Georges-Louis; Drot-Delange, Beatrice; Grandbastien, Monique; Tort, Françoise


    Computer science as a school subject in France is characterized by a succession of promising starts that have not yet been transformed into perennial solutions. The main goal of this article is to analyze this complex situation from a historical perspective, and describe the current rebirth of an optional Computer Science course in the last year…

  19. Curricular and Didactic Conceptions of Interdisciplinarity in the Field of Education: A Socio-Historical Perspective (United States)

    Lenoir, Yves; Hasni, Abdelkrim; Froelich, Alessandra


    Although interdisciplinary approaches to education are found throughout the West, interdisciplinarity is not everywhere conceived and implemented the same way. Adopting a socio-historical perspective, this article presents two conceptions of interdisciplinarity in primary and middle school education (though the conceptions are apparent at other…

  20. A Historical Perspective on Gender Inequality and Development in the World Economy, c. 1850-2000

    NARCIS (Netherlands)

    Dilli, S.D.


    The main objective of this dissertation is to add a historical perspective to the debate on the link between gender inequality and development. To do so, the dissertation first documents global gender differences in life expectancy and sex ratios (to cover health status); in average years of schooli

  1. Mass loss and evolution of stars and star clusters: a personal historical perspective

    NARCIS (Netherlands)

    Lamers, H.J.G.L.M.


    The development and progress of the studies of winds and mass loss from hot stars, from about 1965 up to now, is discussed in a personal historical perspective. The present state of knowledge about stellar winds, based on papers presented at this workshop, is described. About ten years ago the mecha



    Moh. Fathoni


    New Historicism and cultural history have opened up the new approaches to writing histories. However, the last decade national and transnational literary histories have continued to take different approaches, by typical new national literary histories have distinguished the teleology of grand narratives by revised the linear ways into specific subjects and certain conception. In the following discussion, I shall describe how ‘new’ perspective of moral and ideological on history of literary cr...

  3. Scientific cosmology meets western theology: a historical perspective. (United States)

    Gingerich, O


    Traditional sacred geography of Christendom met a challenge not so much from Copernicus' heliocentrism per se as from the greatly expanded vision of the cosmos that it ushered in. The twentieth-century view of the vastness of both space and time has brought revolutionary conceptual changes to the sacred landscape. From a theistic perspective, God is not simply the source of the Big Bang, but the Creator in the larger sense of designer and intender of the universe.

  4. Surgical robotics: the early chronicles: a personal historical perspective. (United States)

    Satava, Richard M


    The use of robotics has been emerging for approximately 75 years, but only during the past 5 years has the potential of robotics been recognized by the surgical community as a whole. This personal perspective chronicles the development of robotics for the general surgical community, the role of the military medical research effort, and many of the major programs that contributed to the current success of robotics.

  5. Hormesis: Decoding Two Sides of the Same Coin

    Directory of Open Access Journals (Sweden)

    Dipita Bhakta-Guha


    Full Text Available In the paradigm of drug administration, determining the correct dosage of a therapeutic is often a challenge. Several drugs have been noted to demonstrate contradictory effects per se at high and low doses. This duality in function of a drug at different concentrations is known as hormesis. Therefore, it becomes necessary to study these biphasic functions in order to understand the mechanistic basis of their effects. In this article, we focus on different molecules and pathways associated with diseases that possess a duality in their function and thus prove to be the seat of hormesis. In particular, we have highlighted the pathways and factors involved in the progression of cancer and how the biphasic behavior of the molecules involved can alter the manifestations of cancer. Because of the pragmatic role that it exhibits, the imminent need is to draw attention to the concept of hormesis. Herein, we also discuss different stressors that trigger hormesis and how stress-mediated responses increase the overall adaptive response of an individual to stress stimulus. We talk about common pathways through which cancer progresses (such as nuclear factor erythroid 2-related factor 2-Kelch-like ECH-associated protein 1 (Nrf2-Keap1, sirtuin-forkhead box O (SIRT-FOXO and others, analyzing how diverse molecules associated with these pathways conform to hormesis.

  6. Contingent and Continuing Employment: Comparative National and Historical Perspectives

    DEFF Research Database (Denmark)

    Marens, Richard; Tackney, Charles T.

    This symposium focuses on the comparative impact of social institutions and labor laws on both contingent and continuing employment. Presenters will apply a wide range of analytical concepts to the history and culture of five individual nations. These concepts include a diverse set of theoretical...... approaches aimed at understanding the web of rules governing comparative industrial and employment relations around the world. The approaches include path dependence, institutional theory, historical materialism, and post-modernism. The central strength of this symposium is its comprehensive and inclusive...

  7. Innovation in science and organizational renewal historical and sociological perspectives

    CERN Document Server

    Münch, Richard


    This book looks at the types of new research organizations that drive scientific innovation and how ground-breaking science transforms research fields and their organization. Based on historical case studies and comparative empirical data, the book presents new and thought-provoking evidence that improves our knowledge and understanding about how new research fields are formed and how research organizations adapt to breakthroughs in science. While the book is firmly based in science history, it discusses more general sociological and policy propositions regarding scientific innovations and organizational change. The volume brings together leading scholars both from the United States and Europe.

  8. A historical perspective on the collaboration between psychoanalysis and neuroscience. (United States)

    Sauvagnat, François; Wiss, Matthias; Clément, Sandra


    The aim of this article is to present and discuss the connections between psychoanalysis and neuroscience from a historical viewpoint. We start by examining how Sigmund Freud can be viewed as a pioneer in the interaction between these two fields. Freud was himself a neurologist and had maintained an interest in biology as he developed the key concepts of psychoanalysis. His ideas regarding psychosomatics are described. We will also explore how the concept of drive is essential to the connection between psychoanalysis and neuroscience. Then, we describe several key actors and historical events and characters at the interface of these two fields, namely Sándor Radó Lawrence S. Kubie and Mc Culloch, the debates that took place during the Macy conferences, as well as the positions of Jacques Lacan, George L. Engel, and Eric Kandel. Finally, we present a synthesis of the main fields in which the connections between psychoanalysis and neuroscience are already fruitful, and those where they should be developed: the classification of mental diseases, the link between the scientific and psychic dimensions, therapeutics, the organization of the body, intersubjectivity, the subjective division and ambivalence, as well as transferential effects like such as the placebo and nocebo effects. In the conclusion, we advocate several strategic alliances and underscore the complementarity between rigorous scientific experimentation and the individualized psychoanalytic approach.

  9. A historical perspective on the male sexual case history. (United States)

    Quallich, Susanne A


    The contemporary sexual medicine case history is grounded in the Biopsychosocial Model and its recognition that the past influences one's current interpretation of symptoms. However, the thread of this model can be found throughout the case studies of the early pioneers of sexology. These early investigators began with examinations of homosexual men, slowly moving toward awareness that male sexuality comprises a continuum, while striving to place sexual behavior in a biologic context. Their perspectives served to establish the groundwork for the emerging construct of sexuality and helped shape current methods for identification of sexual function concerns.

  10. Herbicide phosphinothricin causes direct stimulation hormesis. (United States)

    Dragićević, Milan; Platiša, Jelena; Nikolić, Radomirka; Todorović, Slađana; Bogdanović, Milica; Mitić, Nevena; Simonović, Ana


    Herbicide phosphinothricin (PPT) inhibits glutamine synthetase (GS), a key enzyme in nitrogen assimilation, thus causing ammonia accumulation, glutamine depletion and eventually plant death. However, the growth response of Lotus corniculatus L. plants immersed in solutions with a broad range of PPT concentrations is biphasic, with pronounced stimulating effect on biomass production at concentrations ≤ 50 μM and growth inhibition at higher concentrations. The growth stimulation at low PPT concentrations is a result of activation of chloroplastic isoform GS2, while the growth suppression is caused by inhibition of both cytosolic GS1 and GS2 at higher PPT concentrations. Since the results are obtained in cell-free system (e.g. protein extracts), to which the principles of homeostasis are not applicable, this PPT effect is an unambiguous example of direct stimulation hormesis. A detailed molecular mechanism of concentration-dependent interaction of both PPT and a related GS inhibitor, methionine sulfoximine, with GS holoenzymes is proposed. The mechanism is in concurrence with all experimental and literature data.

  11. Defining hormesis: evaluation of a complex concentration response phenomenon. (United States)

    Kendig, Eric L; Le, Hoa H; Belcher, Scott M


    Hormesis describes dose-response relationships characterized by a reversal of response between low and high doses of chemicals, biological molecules, physical stressors, or other initiators of a response. Acceptance of hormesis as a viable dose-response theory has been limited until recently, in part, because of poor conceptual understanding, ad hoc and inappropriate use, and lack of a defined mechanism. By examining the history of this dose-response theory, it is clear that both pharmacological and toxicological studies provide evidence for hormetic dose responses, but retrospective examination of studies can be problematic at best. Limited scientific evidence and lack of a common lexicon with which to describe these responses have left hormesis open to inappropriate application to unrelated dose-response relationships. Future studies should examine low-dose effects using unbiased, descriptive criteria to further the scientific understanding of this dose response. A clear, concise definition is required to further the limited scientific evidence for hormetic dose responses.

  12. Patient vs. disease in medicine: Historical perspectives and contemporary concerns. (United States)

    von Engelhardt, Dietrich


    Subjectivity and objectivity are central dimensions or perspectives in medicine. During modern times, the "history of the disease" (objectivity) has more and more re-placed the "history of the patient" (subjectivity). But if medicine wants to be human, the physician's and patient's subjectivity and ethics cannot be ignored. During the Middle Ages, the concepts of health and disease are seen from a transcendental point of view, subjectivity was given an objective or spiritual meaning. Processes of secularization, naturalization and individualization deeply influenced medicine in Modern Times. The positivist 19th century laid the foundations of successful scientific medicine; the concept of disease became objective, the length and the quality of life were increased, at the same time, however, medicine witnessed anthropological losses. The 20th century stressed anew the patient's subjectivity and ethics against the scientific objectivity. Integrating psychology and sociology is a similar initiative in this anthropological perspective. The anthropological and ethical permeation of medicine is essential. Disease is not just a physical phenomenon, it is also a psychic, social, and spiritual one. Medical science behaving as human medicine should always and above all see the ill and suffering person.

  13. Historical perspectives on the evolution of surgical procedures in endodontics. (United States)

    Gutmann, James L; Gutmann, Marylou S


    The historical pathway to current surgical endodontic procedures and their applications has been tortuous and tumultuous. Influenced heavily in their development by the European sector, these surgical procedures faced many challenges over the decades. Fortunately for today's practitioners, influential members of the oral surgery community, and a few staunch believers in retaining devitalized teeth, persisted in their investigation of and search for improved procedures that had predictable outcomes. Many so-called "revolutionary" or newer techniques practiced today are but a re-emergence of surgical concepts that were lost in the archives of time. With the advent of evidence-based endodontics, these procedures are now supported extensively by science and by the integration of science into materials usage, technique applications and outcomes research. However, in many respects, this story is just beginning, as the "roots" of surgical endodontics are explored.

  14. Typhoid transmission: a historical perspective on mathematical model development. (United States)

    Bakach, Iurii; Just, Matthew R; Gambhir, Manoj; Fung, Isaac Chun-Hai


    Mathematical models of typhoid transmission were first developed nearly half a century ago. To facilitate a better understanding of the historical development of this field, we reviewed mathematical models of typhoid and summarized their structures and limitations. Eleven models, published in 1971 to 2014, were reviewed. While models of typhoid vaccination are well developed, we highlight the need to better incorporate water, sanitation and hygiene interventions into models of typhoid and other foodborne and waterborne diseases. Mathematical modeling is a powerful tool to test and compare different intervention strategies which is important in the world of limited resources. By working collaboratively, epidemiologists and mathematicians should build better mathematical models of typhoid transmission, including pharmaceutical and non-pharmaceutical interventions, which will be useful in epidemiological and public health practice.

  15. European Welfare State in a Historical Perspective. A Critical Review

    Directory of Open Access Journals (Sweden)

    George Marian ŞTEFAN


    Full Text Available This paper provides an analysis of the historical evolution of the European welfare state, especially after the second half of the nineteenth century. Even if one considers that social protection systems have their origins in the period of German Chancellor Otto von Bismarck, various social problems have been treated in European countries before the Bismarck’s social legislation, beginning with the sixteenth century. In this article we presented mainly (i the origins of social policy systems in Europe, as shown in the literature covered, (ii the conceptual evolution of the so-called “welfare state” and (iii the development of social security schemes based on International Labour Organization typology.

  16. Historical Perspectives and Guidelines for Botulinum Neurotoxin Subtype Nomenclature (United States)

    Peck, Michael W.; Smith, Theresa J.; Anniballi, Fabrizio; Austin, John W.; Bano, Luca; Bradshaw, Marite; Cuervo, Paula; Cheng, Luisa W.; Derman, Yagmur; Dorner, Brigitte G.; Fisher, Audrey; Hill, Karen K.; Kalb, Suzanne R.; Korkeala, Hannu; Lindström, Miia; Lista, Florigio; Lúquez, Carolina; Mazuet, Christelle; Pirazzini, Marco; Popoff, Michel R.; Rossetto, Ornella; Rummel, Andreas; Sesardic, Dorothea; Singh, Bal Ram; Stringer, Sandra C.


    Botulinum neurotoxins are diverse proteins. They are currently represented by at least seven serotypes and more than 40 subtypes. New clostridial strains that produce novel neurotoxin variants are being identified with increasing frequency, which presents challenges when organizing the nomenclature surrounding these neurotoxins. Worldwide, researchers are faced with the possibility that toxins having identical sequences may be given different designations or novel toxins having unique sequences may be given the same designations on publication. In order to minimize these problems, an ad hoc committee consisting of over 20 researchers in the field of botulinum neurotoxin research was convened to discuss the clarification of the issues involved in botulinum neurotoxin nomenclature. This publication presents a historical overview of the issues and provides guidelines for botulinum neurotoxin subtype nomenclature in the future. PMID:28106761

  17. Historical Perspectives and Guidelines for Botulinum Neurotoxin Subtype Nomenclature

    Directory of Open Access Journals (Sweden)

    Michael W. Peck


    Full Text Available Botulinum neurotoxins are diverse proteins. They are currently represented by at least seven serotypes and more than 40 subtypes. New clostridial strains that produce novel neurotoxin variants are being identified with increasing frequency, which presents challenges when organizing the nomenclature surrounding these neurotoxins. Worldwide, researchers are faced with the possibility that toxins having identical sequences may be given different designations or novel toxins having unique sequences may be given the same designations on publication. In order to minimize these problems, an ad hoc committee consisting of over 20 researchers in the field of botulinum neurotoxin research was convened to discuss the clarification of the issues involved in botulinum neurotoxin nomenclature. This publication presents a historical overview of the issues and provides guidelines for botulinum neurotoxin subtype nomenclature in the future.

  18. [The psychodynamics of anti-Judaism in the historical perspective]. (United States)

    Loewenberg, P


    In the author's view, anti-Jewishness is the expression of covert anti-Christianism, which in its turn conceals an unconscious revolt against Christ. Unconscious aggression is unleashed against the Jews, who thus become scapegoats against whom three constantly recurring accusations are levelled: the killing of Christ; the desecration of the Host; and the ritual murder of children. The author traces the history of these accusations from the Middle Ages to the present. The search for scapegoats is a universal phenomenon not limited to anti-Jeweshness but encountered more generally in situations of social and political uncertainty. To substantiate his claims, the author draws upon historical documents from the Second World War dealing with the threat to China from Japan's armed forces, and also makes reference to the race riots in Los Angeles early this year.

  19. Historical perspectives on long distance transport of animals

    Directory of Open Access Journals (Sweden)

    Jean Blancou


    Full Text Available Since Roman Antiquity, domestic and wild animals have been transported over long distances for purposes as different as improvement of livestock production, food supply, scientific interest, public entertainment, war and numerous other purposes. This long distance transportation was originally limited to the Mediterranean area but, during the Middle Ages extended to the rest of Europe. The conquest of the New World was the first major occasion to transport large numbers of horses and other livestock across the oceans. Domestic animals were necessary for the new colonies and their armies. European expansion to Asia and the Pacific also required the transportation of large numbers of domestic animals. Data, figures and description of the conditions of transport of animals as different as wild beasts, horses, camels, elephants or poultry are reported for each historical period.

  20. Radiation hormesis and the linear-no-threshold assumption

    CERN Document Server

    Sanders, Charles L


    Current radiation protection standards are based upon the application of the linear no-threshold (LNT) assumption, which considers that even very low doses of ionizing radiation can cause cancer. The radiation hormesis hypothesis, by contrast, proposes that low-dose ionizing radiation is beneficial. In this book, the author examines all facets of radiation hormesis in detail, including the history of the concept and mechanisms, and presents comprehensive, up-to-date reviews for major cancer types. It is explained how low-dose radiation can in fact decrease all-cause and all-cancer mortality an

  1. Free Fall and Self-Force: an Historical Perspective (United States)

    Spallicci, Alessandro

    Free fall has signed the greatest markings in the history of physics through the leaning Pisa tower, the Woolsthorpe apple tree and the Einstein lift. The perspectives offered by the capture of stars by supermassive black holes are to be cherished, because the study of the motion of falling stars will constitute a giant step forward in the understanding of gravitation in the regime of strong field. After an account on the perception of free fall in ancient times and on the behaviour of a gravitating mass in Newtonian physics, this chapter deals with last century debate on the repulsion for a Schwarzschild-Droste black hole and mentions the issue of an infalling particle velocity at the horizon. Further, black hole perturbations and numerical methods are presented, paving the way to the introduction of the self-force and other back-action related methods. The impact of the perturbations on the motion of the falling particle is computed via the tail, the back-scattered part of the perturbations, or via a radiative Green function. In the former approach, the self-force acts upon the background geodesic; in the latter, the geodesic is conceived in the total (background plus perturbations) field. Regularisation techniques (mode-sum and Riemann-Hurwitz z function) intervene to cancel divergencies coming from the infinitesimal size of the particle. An account is given on the state of the art, including the last results obtained in this most classical problem, together with a perspective encompassing future space gravitational wave interferometry and head-on particle physics experiments. As free fall is patently non-adiabatic, it requires the most sophisticated techniques for studying the evolution of the motion. In this scenario, the potential of the self-consistent approach, by means of which the background geodesic is continuously corrected by the self-force contribution, is examined.

  2. Accurate nomenclature for forefoot nerve entrapment: a historical perspective. (United States)

    Larson, Ethan E; Barrett, Stephen L; Battiston, Bruno; Maloney, Christopher T; Dellon, A Lee


    Current medical nomenclature is often based on the early history of the condition, when the true etiology of the disease or condition was not known. Sadly, this incorrect terminology can become inextricably woven into the lexicon of mainstream medicine. More important, when this is the case, the terminology itself can become integrated into current clinical decision making and ultimately into surgical intervention for the condition. "Morton's neuroma" is perhaps the most striking example of this nomenclature problem in foot and ankle surgery. We aimed to delineate the historical impetus for the terminology still being used today for this condition and to suggest appropriate terminology based on our current understanding of its pathogenesis. We concluded that this symptom complex should be given the diagnosis of nerve compression and be further distinguished by naming the involved nerve, such as compression of the interdigital nerve to the third web space or compression of the third common plantar digital nerve. Although the nomenclature becomes longer, the pathogenesis is correct, and treatment decisions can be made accordingly.

  3. Understanding autism: parents and pediatricians in historical perspective. (United States)

    Silverman, Chloe; Brosco, Jeffrey P


    Both primary care providers and subspecialists in pediatrics encounter families who are actively involved in the diagnosis and treatment of their children. Parents of children with an autism spectrum disorder in particular are often aware of scientific issues, and their expertise and desire for a medical cure for autism sometimes put them at odds with the medical team. We investigated the role of parents and advocates in autism research and treatment over the last 50 years. Our review of scientific publications and archival sources documents how parents and advocacy groups have done the following: (1) organized research funding; (2) constructed clinical research networks; (3) suggested new avenues for research; (4) popularized empirically based therapies; and (5) anticipated paradigmatic shifts in the understanding of autism. We believe that this historical account will help pediatricians and researchers recognize that families can contribute to expert understanding of complex medical conditions such as autism and that the existence of partnerships with families of children with autism is a critical component of future research and treatment programs.

  4. Vertical transmission of arboviruses in mosquitoes: a historical perspective. (United States)

    Lequime, Sebastian; Lambrechts, Louis


    Arthropod-borne viruses (arboviruses) are mainly transmitted horizontally among vertebrate hosts by blood-feeding invertebrate vectors, but can also be transmitted vertically in the vector from an infected female to its offspring. Vertical transmission (VT) is considered a possible mechanism for the persistence of arboviruses during periods unfavorable for horizontal transmission, but the extent and epidemiological significance of this phenomenon have remained controversial. To help resolve this question, we reviewed over a century of published literature on VT to analyze historical trends of scientific investigations on experimental and natural occurrence of VT in mosquitoes. Our synthesis highlights the influence of major events of public health significance in arbovirology on the number of VT publications. Epidemiological landmarks such as emergence events have significantly stimulated VT research. Our analysis also reveals the association between the evolution of virological assays and the probability of VT detection. Increased sensitivity and higher-throughput of modern laboratory assays resulted in enhanced VT detection. In general, VT contribution to arbovirus persistence is likely modest because vertically infected mosquitoes are rarely observed in nature. Taken together, however, our results call for caution when interpreting VT studies because their conclusions are context- and method-dependent.

  5. The (deMilitarization of Humanitarian Aid: A Historical Perspective

    Directory of Open Access Journals (Sweden)

    Marc-Antoine Pérouse de Montclos


    Full Text Available Humanitarian workers often complain that international aid to victims of armed conflicts is more and more militarized because relief organizations are embedded into peacekeeping operations, used as a “force multiplier”, or manipulated as an instrument of diplomacy by proxy. Historically, however, charity has always been a military issue in times of war. We can distinguish four types of militarization of relief organizations in this regard. First is the use of charities to make “war by proxy”, as in Afghanistan or Nicaragua in the 1980s. The second pattern is “embedment”, like the Red Cross during the two world wars. The third is “self-defense”, as with the Order of Saint John of Jerusalem (now Malta in the 12th Century. The fourth, finally, is the model of “International Brigades” alongside the Spanish Republicans in 1936 or various liberation movements in the 1970s. In comparison, humanitarian aid today appears to be much less militarized. However, this perception also depends on the various definitions of the word “humanitarian”.

  6. Reflexes from the lungs and airways: historical perspective. (United States)

    Widdicombe, John


    Historical aspects of respiratory reflexes from the lungs and airways are reviewed, up until about 10 yr ago. For most of the 19th century, the possible reflex inputs into the "respiratory center," the position of which had been identified, were very speculative. There was little concept of reflex control of the pattern of breathing. Then, in 1868, Breuer published his paper on "The self-steering of respiration via the Nervus Vagus." For the first time this established the role of vagal inflation and deflation reflexes in determining the pattern of breathing. Head later extended Breuer's work, and Kratschmer laid a similar basis for reflexes from the nose and larynx. Then, 50-60 yr later, the development of the thermionic valve and the oscilloscope allowed recording action potentials from single nerve fibers in the vagus. In 1933, Adrian showed that slowly adapting pulmonary stretch receptors were responsible for the inflation reflex. Later, Knowlton and Larrabee described rapidly adapting receptors and showed that they mediated deep augmented breaths and the deflation reflex. Still later, it was established that rapidly adapting receptors were, at least in part, responsible for cough. In 1954, Paintal began his study of C-fiber receptors (J receptors), work greatly extended by the Coleridges. Since approximately 10 yr ago, when the field of this review stops, there has been an explosion of research on lung and airway receptors, many aspects of which are dealt with in other papers in this series.

  7. Free fall and self-force: an historical perspective

    CERN Document Server

    Spallicci, Alessandro


    Free fall has signed the greatest markings in the history of physics through the leaning Pisa tower, the Cambridge apple tree and the Einstein lift. The perspectives offered by the capture of stars by supermassive black holes are to be cherished, because the study of the motion of falling stars will constitute a giant step forward in the understanding of gravitation in the regime of strong field. After an account on the perception of free fall in ancient times and on the behaviour of a gravitating mass in Newtonian physics, this chapter deals with last century debate on the repulsion for a Schwarzschild black hole and mentions the issue of an infalling particle velocity at the horizon. Further, black hole perturbations and numerical methods are presented, paving the way to the introduction of the self-force and other back-action related methods. The impact of the perturbations on the motion of the falling particle is computed via the tail, the back-scattered part of the perturbations, or via a radiative Green...

  8. A historical perspective on malaria control in Brazil. (United States)

    Griffing, Sean Michael; Tauil, Pedro Luiz; Udhayakumar, Venkatachalam; Silva-Flannery, Luciana


    Malaria has always been an important public health problem in Brazil. The early history of Brazilian malaria and its control was powered by colonisation by Europeans and the forced relocation of Africans as slaves. Internal migration brought malaria to many regions in Brazil where, given suitable Anopheles mosquito vectors, it thrived. Almost from the start, officials recognised the problem malaria presented to economic development, but early control efforts were hampered by still developing public health control and ignorance of the underlying biology and ecology of malaria. Multiple regional and national malaria control efforts have been attempted with varying success. At present, the Amazon Basin accounts for 99% of Brazil's reported malaria cases with regional increases in incidence often associated with large scale public works or migration. Here, we provide an exhaustive summary of primary literature in English, Spanish and Portuguese regarding Brazilian malaria control. Our goal was not to interpret the history of Brazilian malaria control from a particular political or theoretical perspective, but rather to provide a straightforward, chronological narrative of the events that have transpired in Brazil over the past 200 years and identify common themes.

  9. NOx emissions in China: historical trends and future perspectives (United States)

    Zhao, B.; Wang, S. X.; Liu, H.; Xu, J. Y.; Fu, K.; Klimont, Z.; Hao, J. M.; He, K. B.; Cofala, J.; Amann, M.


    Nitrogen oxides (NOx) are key pollutants for the improvement of ambient air quality. Within this study we estimated the historical NOx emissions in China for the period 1995-2010, and calculated future NOx emissions every five years until 2030 under six emission scenarios. Driven by the fast growth of energy consumption, we estimate the NOx emissions in China increased rapidly from 11.0 Mt in 1995 to 26.1 Mt in 2010. Power plants, industry and transportation were major sources of NOx emissions, accounting for 28.4%, 34.0%, and 25.4% of the total NOx emissions in 2010, respectively. Two energy scenarios, a business as usual scenario (BAU) and an alternative policy scenario (PC), were developed to project future energy consumption. In 2030, total energy consumption is projected to increase by 64% and 27% from 2010 level respectively. Three sets of end-of-pipe pollution control measures, including baseline, progressive, and stringent control case, were developed for each energy scenario, thereby constituting six emission scenarios. By 2030, the total NOx emissions are projected to increase (compared to 2010) by 36% in the baseline while policy cases result in reduction up to 61% in the most ambitious case with stringent control measures. More than a third of the reduction achieved by 2030 between least and most ambitious scenario comes from power sector, and more than half is distributed equally between industry and transportation sectors. Selective catalytic reduction dominates the NOx emission reductions in power plants, while life style changes, control measures for industrial boilers and cement production are major contributors to reductions in industry. Timely enforcement of legislation on heavy-duty vehicles would contribute significantly to NOx emission reductions. About 30% of the NOx emission reduction in 2020 and 40% of the NOx emission reduction in 2030 could be treated as the ancillary benefit of energy conservation. Sensitivity analysis was conducted to

  10. Concepts of neurosurgical management of chronic subdural haematoma: historical perspectives. (United States)

    Weigel, R; Krauss, J K; Schmiedek, P


    The history of chronic subdural haematoma (CSH), spanning from its possibly earliest beginnings throughout the centuries until the early 1980s, was investigated within the context of four different epochs. In the 'era of uncertainty', successful trephination, the modem method of choice for the treatment of CSH, was developed by neolithic men. Various historical sources indicate that patients with CSH might have undergone surgery at that time. CSH might have been one of the ailments that had spectacular courses of salvation after trephination. The entity of CSH was first described in the 'era of pioneers' in the seventeenth century by Johann Jacob Wepfer. The misconception of 'pachymeningitis hemorrhagica interna' was introduced by Rudolf Virchow in 1857. By the end of the nineteenth century it became more widely accepted that trauma was a possible cause of CSH. Successful neurosurgical treatment of CSH was first reported by Hulke in 1883. Putnam and Cushing, in 1925, focused on surgery as the treatment of choice for CSH. In the 'era of diagnostic refinement', the introduction of pneumencephalography and angiography allowed the diagnosis of CSH much earlier. Subsequently, the typical signs and symptoms of patients suffering from CSH changed from apathy and coma to headaches and discrete focal neurological symptoms. In the 'era of surgical routine', neurosurgical approaches became smaller and less invasive. Removal of the haematoma was identified as the primary goal of surgery. The use of closed system drainage markedly improved reexpansion of the brain after surgery. Burr hole craniostomy and twist drill craniostomy became the surgical treatment of first choice because of their low morbidity and mortality. There is growing evidence, however, that the neurosurgical learning curve has reached a plateau.

  11. Clinical trials in luminal Crohn's disease: a historical perspective. (United States)

    Hindryckx, Pieter; Baert, Filip; Hart, Ailsa; Armuzzi, Alessandro; Panès, Julian; Peyrin-Biroulet, Laurent


    It goes back to 1932 when Dr. Burrill Bernard Crohn and co-workers published their landmark paper, describing regional ileitis as a disease entity. However, clinical trial research has been developing rather slowly in luminal Crohn's disease. It took until the early seventies before the first randomized clinical trial was set up by the National Co-operative Crohn's Disease Study (NCCDS) group. Although the efforts of this group triggered a first wave of clinical trials in Crohn's disease, the lack of guidelines for conducting a clinical trial in this research area resulted in a variety of study designs and much criticism. Besides having a rather small sample size and a short follow-up time, they were often characterized by vague and subjective assessment of disease activity and treatment response. Following the advent of a new and very potent drug class in the late nineties, the anti-TNF agents, investigators started to re-think their study protocols and the first guidelines were set up by the regulatory authorities. Over the last 15years, clinical trials in luminal Crohn's disease have been evolving significantly. Inclusion criteria have been shifting from clinical scores such as Crohn's Disease Activity Index (CDAI) to more objective disease activity parameters such as biomarkers (C-reactive protein and faecal calprotectin) and endoscopic lesions. Primary endpoints have been developing from clinical response to corticosteroid-free remission and more ambitious end-points such as mucosal healing. In this paper, we will give a historical overview on clinical trials in luminal Crohn's disease, before and within the biologic era, and provide insight into how they have shaped our current understanding of trial designs in Crohn's disease.

  12. NOx emissions in China: historical trends and future perspectives

    Directory of Open Access Journals (Sweden)

    B. Zhao


    Full Text Available Nitrogen oxides (NOx are key pollutants for the improvement of ambient air quality. Within this study we estimated the historical NOx emissions in China for the period 1995–2010, and calculated future NOx emissions every five years until 2030 under six emission scenarios. Driven by the fast growth of energy consumption, we estimate the NOx emissions in China increased rapidly from 11.0 Mt in 1995 to 26.1 Mt in 2010. Power plants, industry and transportation were major sources of NOx emissions, accounting for 28.4, 34.0, and 25.4% of the total NOx emissions in 2010, respectively. Two energy scenarios, a business as usual scenario (BAU and an alternative policy scenario (PC, were developed to project future energy consumption. In 2030, total energy consumption is projected to increase by 64 and 27% from 2010 level respectively. Three sets of end-of-pipe pollution control measures, including baseline, progressive, and stringent control case, were developed for each energy scenario, thereby constituting six emission scenarios. By 2030, the total NOx emissions are projected to increase (compared to 2010 by 36% in the baseline while policy cases result in reduction up to 61% in the most ambitious case with stringent control measures. More than a third of the reduction achieved by 2030 between least and most ambitious scenario comes from power sector and more than half is distributed equally between industry and transportation sectors. Selective Catalytic Reduction dominates the NOx emission reductions in power plants, while life style changes, control measures for industrial boilers and cement production are major contributors to reductions in industry. Timely enforcement of legislation on heavy duty vehicles would contribute significantly to NOx emission reductions. About 30% of the NOx emission reduction in 2020, and 40% of the NOx emission reduction in 2030 could be treated as the ancillary benefit of energy conservation. Sensitivity analysis was

  13. Promoting astronomy in developing countries: A historical perspective (United States)

    Kochhar, Rk


    Any international effort to promote astronomy world wide today must necessarily take into account its cultural and historical component. The past few decades have ushered in an age, which we may call the Age of Cultural Copernicanism. In analogy with the cosmological principle that the universe has no preferred location or direction, Cultural Copernicanism would imply that no cultural or geographical area, or ethnic or social group, can be deemed to constitute a superior entity or a benchmark for judging or evaluating others. In this framework, astronomy (as well as science in general) is perceived as a multi-stage civilizational cumulus where each stage builds on the knowledge gained in the previous stages and in turn leads to the next. This framework however is a recent development. The 19th century historiography consciously projected modern science as a characteristic product of the Western civilization decoupled from and superior to its antecedents, with the implication that all material and ideological benefits arising from modern science were reserved for the West. As a reaction to this, the orientalized East has often tended to view modern science as "their" science, distance itself from its intellectual aspects, and seek to defend, protect and reinvent "our" science and the alleged (anti-science) Eastern mode of thought. This defensive mindset works against the propagation of modern astronomy in most of the non-Western countries. There is thus need to construct a history of world astronomy that is truly universal and unselfconscious. Similarly , the planetarium programs , for use the world over, should be culturally sensitive. IAU can help produce cultural-specific modules. Equipped with this paradigmatic background, we can now address the question of actual means to be adopted for the task at hand. Astronomical activity requires a certain minimum level of industrial activity support. Long-term maintenance of astronomical equipment is not a trivial task

  14. Surgery for anterior cruciate ligament deficiency: a historical perspective. (United States)

    Schindler, Oliver S


    ACL reconstruction as a common procedure within the realm of most surgeons' ability. More recently, the principle of anatomic ACL reconstruction, aiming at the functional restoration of native ACL dimensions and insertion sites, has been introduced, superseding the somewhat ill-advised concept of isometric graft placement. Double-bundle reconstruction is gaining in popularity, and combined extra- and intra-articular procedures are seeing a revival, but more accurate and reliable pre- and post-operative assessment tools are required to provide customised treatment options and appropriate evaluation and comparability of long-term results. Modern ACL surgery is united in the common goal of re-establishing joint homoeostasis with normal knee kinematics and function which may ultimately assist in reducing the prevalence of post-operative joint degeneration. This review hopes to provide an insight into the historical developments of ACL surgery and the various controversies surrounding its progress. Level of evidence V.

  15. North American osprey populations and contaminants: Historic and contemporary perspectives (United States)

    Henny, Charles J.; Grove, Robert A.; Kaiser, James L.; Johnson, Branden L.


    Osprey (Pandion haliaetus) populations were adversely affected by DDT and perhaps other contaminants in the United States and elsewhere. Reduced productivity, eggshell thinning, and high DDE concentrations in eggs were the signs associated with declining osprey populations in the 1950s, 1960s, and 1970s. The species was one of the first studied on a large scale to bring contaminant issues into focus. Although few quantitative population data were available prior to the 1960s, many osprey populations in North America were studied during the 1960s and 1970s with much learned about basic life history and biology. This article reviews the historical and current effects of contaminants on regional osprey populations. Breeding populations in many regions of North America showed post-DDT-era (1972) population increases of varying magnitudes, with many populations now appearing to stabilize at much higher numbers than initially reported in the 1970s and 1980s. However, the magnitude of regional population increases in the United States between 1981 (first Nationwide Survey, ≈8,000 pairs), when some recovery had already occurred, 1994 (second survey, ≈14,200), and 2001 (third survey, ≈16,000–19,000), or any other years, is likely not a simple response to the release from earlier contaminant effects, but a response to multi-factorial effects. This indirect "contaminant effects" measurement comparing changes (i.e., recovery) in post-DDT-era population numbers over time is probably confounded by changing human attitudes toward birds of prey (shooting, destroying nests, etc.), changing habitats, changing fish populations, and perhaps competition from other species. The species' adaptation to newly created reservoirs and its increasing use of artificial nesting structures (power poles, nesting platforms, cell towers, channel markers, offshore duck blinds, etc.) are two important factors. The timing of the initial use of artificial nesting structures, which replaced

  16. Woodland caribou management in Alberta: historical perspectives and future opportunities

    Directory of Open Access Journals (Sweden)

    Elston H. Dzus


    Full Text Available Woodland caribou conservation has been the topic of much debate for the past few decades. By the late 1970s there was growing concern about declining woodland caribou populations and the interaction between industrial activities and woodland caribou. Initial concerns led to the closure of the licensed hunting season in 1981. Early confrontation between government and industry in the late 1980s transformed into a series of evolving collaborative ventures. Improving our understanding of the basic ecology of woodland caribou in Alberta was at the center of early research efforts; more recent studies have examined the effects of industrial activities on caribou and effectiveness of various mitigation factors. Despite having amassed an impressive body of information from a research and monitoring perspective, progress on implementing effective management actions has been less dramatic. Industry has endured significant costs implementing a variety of perceived conservation initiatives, but caribou populations continued to decline through the last few decades. While some parties feel more research is needed, there is growing consensus that changes to habitat as induced by human activities are important factors influencing current caribou declines. Predation is a proximate cause of most caribou mortality. Climate change mediated alterations to habitat and predator-prey interactions remain a key source of uncertainty relative to future caribou population trends. Management actions will need to deal with long term habitat changes associated with human land use and short term implications of increased predation. In 2005, the provincial minister responsible for caribou conservation responded to the draft 2004 recovery plan and created the Alberta Caribou Committee (ACC. The goal of the ACC is to maintain and recover woodland caribou in Alberta’s forest ecosystems while providing opportunities for resource development, following guidance provided by the

  17. Reliability and risk analysis data base development: an historical perspective

    Energy Technology Data Exchange (ETDEWEB)

    Fragola, Joseph R


    altogether (Cushing, M. et al., Comparison of electronics-reliability assessment approaches. Trans. Reliab., 42 (1993) 542-546 Wat son, G.F., MIL Reliability: a new approach. IEEE Spectrum, 29 (1992) 46-49). Authors who have suggested that the concept of generic data collection be abolished in favor of a physics-of-failure approach (Watson, G.F., MIL Reliability: a new approach. IEEE Spectrum, 29 (1992) 46-49) now seem to be suggesting that the concept of 'failure rate' be banished altogether and with it the concept of reliability prediction (Pecht., M. and Nash, F., Predicting the reliability of electronic equipment. Proc. IEEE, 82 (1994) 992-1004). There can be no doubt that abuses of generic data exist and that the physics-of-failure approach has merit, especially in design development, however, does the situation really justify the abandonment of the collection, analysis, and classification of empirical failure data and the elimination of reliability or risk prediction? If not, can the concepts of 'failure rate' and 'prediction' be redefined so as to allow for meaningful support to be provided to logical decision making? This paper reviews both the logical and historical context within which reliability and risk data bases have been developed so as to generate an understanding of the motivations for and the assumptions underlying their development. Further, an attempt is made to clarify what appears to be fundamental confusion in the field of reliability and risk analysis. With these clarifications in hand, a restructuring of the conceptual basis for reliability data base development and reliability predictions is suggested, and some hopeful recent developments are reported upon.

  18. A Short Account of RRKM Theory of Unimolecular Reactions and of Marcus Theory of Electron Transfer in a Historical Perspective (United States)

    Di Giacomo, Francesco


    The RRKM Theory of Unimolecular Reactions and Marcus Theory of Electron Transfer are here briefly discussed in a historical perspective. In the final section, after a general discussion on the educational usefulness of teaching chemistry in a historical framework, hints are given on how some characteristics of Marcus' work could be introduced in…

  19. Advances for prosthetic technology from historical perspective to current status to future application

    CERN Document Server

    LeMoyne, Robert


    This book focuses on the advances in transtibial prosthetic technology and targets research in the evolution of the powered prosthesis such as the BiOM, which was derived from considerable research and development at the Massachusetts Institute of Technology. The concept of the book spans the historical evolution of prosthetic applications from passive to new and futuristic robotic prosthetic technologies.  The author describes the reasons for amputation, surgical procedures, and an historical perspective of the prosthesis for the lower limb. He also addresses the phases and sub-phases of gait and compensatory mechanisms arising for a transtibial prosthesis and links the compensatory mechanisms to long-term morbidities.  The general technologies for gait analysis central to prosthetic design and the inherent biomechanics foundations for analysis are also explored.  The book reports on recent-past to current-term applications with passive elastic prostheses.  The core of the book deals with futuristic robo...

  20. Historical perspective and contemporary management of acute coronary syndromes: from MONA to THROMBINS2. (United States)

    Kline, Kristopher P; Conti, C Richard; Winchester, David E


    Acute coronary syndrome (ACS) remains a major burden on morbidity and mortality in the United States. Medical professionals and students often use the mnemonic 'MONA' (morphine, oxygen, nitroglycerin and aspirin) to recall treatments for ACS; however, this list of therapies is outdated. We provide a historical perspective on 'MONA,' attempt to uncover its origin in the medical literature, and demonstrate the myriad changes that have occurred over the last 50 years of ACS management. We have developed a novel mnemonic, 'THROMBINS2' (thienopyridines, heparin/enoxaparin, renin-angiotensin system blockers, oxygen, morphine, beta blocker, intervention, nitroglycerin, statin/salicylate) to help bedside clinicians recall all the elements of contemporary ACS management. We demonstrate the mortality benefit for each component of contemporary ACS management, correlating the continued improvement with historical data on mortality after myocardial infarction. We encourage providers to utilize this mnemonic to explore options and guide treatments in ACS patients.

  1. The Occurrence of Hormesis in Plants and Algae

    DEFF Research Database (Denmark)

    Cedergreen, Nina; Streibig, Jens C; Kudsk, Per


    fungicide and binary mixtures thereof. In total 687 dose-response curves were included in the database. The study showed that both the frequency and the magnitude of the hormetic response depended on the endpoint being measured. Dry weight at harvest showed a higher frequency and a larger hormetic response...... compared to relative growth rates. Evaluating hormesis for relative growth rates for all species showed that 25% to 76% of the curves for each species had treatments above 105% of the control. Fitting the data with a dose-response model including a parameter for hormesis showed that the average growth...... for acifluorfen and terbuthylazine. The concentration ranges of the hormetic part of the dose-response curves corresponded well with literature values....

  2. A Method to Evaluate Hormesis in Nanoparticle Dose-Responses


    Nascarella, Marc A.; Calabrese, Edward J.


    The term hormesis describes a dose-response relationship that is characterized by a response that is opposite above and below the toxicological or pharmacological threshold. Previous reports have shown that this relationship is ubiquitous in the response of pharmaceuticals, metals, organic chemicals, radiation, and physical stressor agents. Recent reports have also indicated that certain nanoparticles (NPs) may also exhibit a hormetic dose-response. We describe the application of three previo...

  3. Reductive stress impairs myoblasts mitochondrial function and triggers mitochondrial hormesis. (United States)

    Singh, François; Charles, Anne-Laure; Schlagowski, Anna-Isabel; Bouitbir, Jamal; Bonifacio, Annalisa; Piquard, François; Krähenbühl, Stephan; Geny, Bernard; Zoll, Joffrey


    Even though oxidative stress damage from excessive production of ROS is a well known phenomenon, the impact of reductive stress remains poorly understood. This study tested the hypothesis that cellular reductive stress could lead to mitochondrial malfunction, triggering a mitochondrial hormesis (mitohormesis) phenomenon able to protect mitochondria from the deleterious effects of statins. We performed several in vitro experiments on L6 myoblasts and studied the effects of N-acetylcysteine (NAC) at different exposure times. Direct NAC exposure (1mM) led to reductive stress, impairing mitochondrial function by decreasing maximal mitochondrial respiration and increasing H₂O₂production. After 24h of incubation, the reactive oxygen species (ROS) production was increased. The resulting mitochondrial oxidation activated mitochondrial biogenesis pathways at the mRNA level. After one week of exposure, mitochondria were well-adapted as shown by the decrease of cellular ROS, the increase of mitochondrial content, as well as of the antioxidant capacities. Atorvastatin (ATO) exposure (100μM) for 24h increased ROS levels, reduced the percentage of live cells, and increased the total percentage of apoptotic cells. NAC exposure during 3days failed to protect cells from the deleterious effects of statins. On the other hand, NAC pretreatment during one week triggered mitochondrial hormesis and reduced the deleterious effect of statins. These results contribute to a better understanding of the redox-dependant pathways linked to mitochondria, showing that reductive stress could trigger mitochondrial hormesis phenomenon.

  4. The 10th anniversary of the publication of genes and environment: memoir of establishing the Japanese environmental mutagen society and a proposal for a new collaborative study on mutagenic hormesis. (United States)

    Sutou, Shizuyo


    The Japanese Environmental Mutagen Society (JEMS) was established in 1972 by 147 members, 11 of whom are still on the active list as of May 1, 2016. As one of them, I introduce some historic topics here. These include 1) establishment of JEMS, 2) the issue of 2-(2-furyl)-3-(3-nitro-2-furyl)acrylamide (AF-2), 3) the Mammalian Mutagenicity Study Group (MMS) and its achievements, and 4) the Collaborative Study Group of the Micronucleus Test (CSGMT) and its achievements. In addition to these historic matters, some of which are still ongoing, a new collaborative study is proposed on adaptive response or hormesis by mutagens. There is a close relationship between mutagens and carcinogens, the dose-response relationship of which has been thought to follow the linear no-threshold model (LNT). LNT was fabricated on the basis of Drosophila sperm experiments using high dose radiation delivered in a short period. The fallacious 60 years-old LNT is applied to cancer induction by radiation without solid data and then to cancer induction by carcinogens also without solid data. Therefore, even the smallest amount of carcinogens is postulated to be carcinogenic without thresholds now. Radiation hormesis is observed in a large variety of living organisms; radiation is beneficial at low doses, but hazardous at high doses. There is a threshold at the boundary between benefit and hazard. Hormesis denies LNT. Not a few papers report existence of chemical hormesis. If mutagens and carcinogens show hormesis, the linear dose-response relationship in mutagenesis and carcinogenesis is denied and thresholds can be introduced.

  5. Johann P. Arnason & Kurt A. Raaflaub, The Roman Empire in Context: Historical and Comparative Perspectives (Chichester: Wiley & Sons, 2011

    Directory of Open Access Journals (Sweden)

    Michael Gibbons


    Full Text Available Arnason and Raaflaub’s edited volume, The Roman Empire in Context: Historical and Comparative Perspectives, is the fifth volume in a series entitled The Ancient World: Comparative Histories. The overarching aim of the series is to bring a comparative perspective to studies of ancient histories, and earlier titles focus either on content or geography. This is the only volume to date that focuses on a specific civilization, and Rome is of course significant enough to merit its own volume.

  6. On the origins and the historical roots of the Higgs boson research from a bibliometric perspective

    CERN Document Server

    Barth, Andreas; Bornmann, Lutz; Mutz, Ruediger


    Subject of our present paper is the analysis of the origins or historical roots of the Higgs boson research from a bibliometric perspective, using a segmented regression analysis in a reference publication year spectroscopy (RPYS). Our analysis is based on the references cited in the Higgs boson publications published since 1974. The objective of our analysis consists of identifying concrete individual publications in the Higgs boson research context to which the scientific community frequently had referred to. As a consequence, we are interested in seminal works which contributed to a high extent to the discovery of the Higgs boson. Our results show that researchers in the Higgs boson field preferably refer to more recently published papers - particular papers published since the beginning of the sixties. For example, our analysis reveals seven major contributions which appeared within the sixties: Englert and Brout (1964), Higgs (1964, 2 papers), and Guralnik et al. (1964) on the Higgs mechanism as well as ...

  7. On the concept of “variant” in lexicon studies from a historic-variational perspective

    Directory of Open Access Journals (Sweden)

    Américo Venâncio Lopes Machado Filho


    Full Text Available Even though the concept of linguistic variant has been fully established in contemporary sociolinguistic studies, it demands a theoretical review when it is considered from the perspective of lexicon studies, especially when related to historical and variational biases. In this paper, we present limits on identification and characterization of lexical variation, considering formal changes that may occur at other levels of analysis, especially at the morphological or phonetic ones. To support the reflections on the topic, we discuss the process of lexicon constitution in Portuguese and the results of etymological convergence and divergence present in the history of the language. Based on the analysis presented, it is proposed that research on lexical variation should incorporate to this notion any significant formal or content changes.

  8. Assessing the Constructive Potential of Union Citizenship A Socio-Historical Perspective

    Directory of Open Access Journals (Sweden)

    Antje Wiener


    Full Text Available In European integration studies citizenship policy has not received much attention as a practice. Instead much of the literature has predominantly focused on legal assessments of Union citizenship shedding light on the limitations of supranational citizenship compared to the familiar statist concepts of citizenship. Legal approaches have thus often adopted a minimalist perspective on citizenship, establishing what Union citizenship is not leaving aside the constructive potential of Union citizenship. This paper seeks to demonstrate that a constructive perspective on the practice of citizenship facilitates valuable information about the creation of the institutionalised terms of citizenship over time. If it is true that Union citizenship is different from other types of citizenship, what is new about it? Constructive approaches suggest, that if we are to establish the dynamics which characterise Union citizenship analyses need to allow for a way of appreciating historical variability of context and contents of citizenship. To that end the major part of this paper seeks to develop a way of assessing the constructive potential of citizenship based on its newly institutionalised terms such as the shared values, objectives and regulations that have been established by citizenship policy over time. Beyond describing the emergence of EC/EU citizenship the paper promotes a systematic approach to reconstruct the policy in this supranational context. It is assumed that citizenship did not emerge out of the blue on the agenda of the Maastricht Intergovernmental Conference but that it is possible to identify agenda-setting steps in earlier stages of the policy process. If this assumption is correct, then a historical account could bring the various steps of citizenship policy which led to the history-making decision at Maastricht summit to the fore.

  9. Assessing the Constructive Potential of Union Citizenship – A Socio-Historical Perspective

    Directory of Open Access Journals (Sweden)

    Antje Wiener


    Full Text Available In European integration studies citizenship policy has not received much attention as a practice. Instead much of the literature has predominantly focused on legal assessments of Union citizenship shedding light on the limitations of supranational citizenship – compared to the familiar statist concepts of citizenship. Legal approaches have thus often adopted a minimalist perspective on citizenship, establishing what Union citizenship is not leaving aside the constructive potential of Union citizenship. This paper seeks to demonstrate that a constructive perspective on the practice of citizenship facilitates valuable information about the creation of the institutionalised terms of citizenship over time. If it is true that Union citizenship is different from other types of citizenship, what is new about it? Constructive approaches suggest, that if we are to establish the dynamics which characterise Union citizenship analyses need to allow for a way of appreciating historical variability of context and contents of citizenship. To that end the major part of this paper seeks to develop a way of assessing the constructive potential of citizenship based on its newly institutionalised terms such as the shared values, objectives and regulations that have been established by citizenship policy over time. Beyond describing the emergence of EC/EU citizenship the paper promotes a systematic approach to reconstruct the policy in this supranational context. It is assumed that citizenship did not emerge out of the blue on the agenda of the Maastricht Intergovernmental Conference but that it is possible to identify agenda-setting steps in earlier stages of the policy process. If this assumption is correct, then a historical account could bring the various steps of citizenship policy which led to the history-making decision at Maastricht summit to the fore.

  10. Searching for social capital: historical perspectives on health, poverty and culture. (United States)

    Welshman, John


    Social capital has been seen as having a positive effect on health, and the concept of social capital has been viewed as of central importance to debates about healthy, sustainable communities. More generally, behaviour and its relationship with health has become much more central to policy-making, as illustrated in the Choosing Health White Paper (2005), and the concept of social capital has been one influence on the concept of social exclusion. Robert Putnam's arguments, both those expressed in Making Democracy Work (1993) and the revised version seen in Bowling Alone (2000) have been taken up by numerous social scientists and policy-makers. But despite the explicitly historical perspective that Putnam employs in Bowling Alone in particular, the history of social capital remains rather neglected in the available literature. This article is concerned with providing a historical perspective on social capital, especially the ways in which social investigators have viewed the relationships between health, poverty and behaviour. The article puts social capital alongside that of 'underclass' concepts such as the culture of poverty thesis, and examines how the latter has been invented and reinvented in the U.K. and the U.S.A. over the last 120 years. It argues that there are important similarities between the culture of poverty and social capital, but also significant differences, and these have implications for current policy initiatives. One way of analysing concepts like social capital and social exclusion more rigorously is by locating them within this longer-term history of social investigation, in which debates about health, poverty, and culture have been of

  11. Paradigm lost, paradigm found: The re-emergence of hormesis as a fundamental dose response model in the toxicological sciences

    Energy Technology Data Exchange (ETDEWEB)

    Calabrese, Edward J. [Environmental Health Sciences, School of Public Health, Morrill I, N344, University of Massachusetts, Amherst, MA 01003 (United States)]. E-mail:


    This paper provides an assessment of the toxicological basis of the hormetic dose-response relationship including issues relating to its reproducibility, frequency, and generalizability across biological models, endpoints measured and chemical class/physical stressors and implications for risk assessment. The quantitative features of the hormetic dose response are described and placed within toxicological context that considers study design, temporal assessment, mechanism, and experimental model/population heterogeneity. Particular emphasis is placed on an historical evaluation of why the field of toxicology rejected hormesis in favor of dose response models such as the threshold model for assessing non-carcinogens and linear no threshold (LNT) models for assessing carcinogens. The paper argues that such decisions were principally based on complex historical factors that emerged from the intense and protracted conflict between what is now called traditional medicine and homeopathy and the overly dominating influence of regulatory agencies on the toxicological intellectual agenda. Such regulatory agency influence emphasized hazard/risk assessment goals such as the derivation of no observed adverse effect levels (NOAELs) and the lowest observed adverse effect levels (LOAELs) which were derived principally from high dose studies using few doses, a feature which restricted perceptions and distorted judgments of several generations of toxicologists concerning the nature of the dose-response continuum. Such historical and technical blind spots lead the field of toxicology to not only reject an established dose-response model (hormesis), but also the model that was more common and fundamental than those that the field accepted. - The quantitative features of the hormetic dose/response are described and placed within the context of toxicology.

  12. The Adoption of Smoking and Its Effect on the Mortality Gender Gap in Netherlands: A Historical Perspective

    NARCIS (Netherlands)

    Janssen, F.; van Poppel, F.W.A.


    We examine in depth the effect of differences in the smoking adoption patterns of men and women on the mortality gender gap in Netherlands, employing a historical perspective. Using an indirect estimation technique based on observed lung cancer mortality from1931 to 2012, we estimated lifetime smoki

  13. Early Intervention Approaches to Enhance the Peer-Related Social Competence of Young Children with Developmental Delays: A Historical Perspective (United States)

    Guralnick, Michael J.


    This article presents a framework for future research and program development designed to support children's peer-related social competence. Intervention research is examined within a historical perspective culminating with a discussion of contemporary translational approaches capable of integrating models of normative development, developmental…

  14. Object Recognition and Object Segregation in Infancy: Historical Perspective, Theoretical Significance, "Kinds" of Knowledge, and Relation to Object Categorization. (United States)

    Quinn, Paul C.; Bhatt, Ramesh S.


    Reflects on Needham's findings on infants' object recognition and segregation. Examines the role for perceptual bias in explaining infant performance, places Needham's studies in historical perspective, and assesses their theoretical significance. Discusses the merits of positing different kinds of information sources for object segregation, and…

  15. Strategy for Self-Centered Development from the Perspective of an Historical Analysis of Development

    Directory of Open Access Journals (Sweden)

    Alfredo Pérez Sánchez


    Full Text Available After acknowledging the three phases of historical analysis of development, and especially considering the research work done in the last twenty-five years by the Germans Dieter Sengcheus and Ulrich Mezel, the author presents the principle elements of a self-centered development strategy which highlights the following perspectives:dissociation, economic restructuring, and the new forms of an international division of labor among Third World economies.This document calls into question the underlying operation of the conventional theory of development and its current policy, which call for the increasing integration of the Third World in the world market as a means of going beyond development as it is commonly understood. Though being an integral element in the theory of self-centereddevelopment, temporary dissociation from the world market is proposed. The justification for the strategy of dissociation, excepting the recourse to some historical and paradigmatic reflections sketched by Friedrich List, has kept itself, of necessity, to the global and abstract level. This position is nothing, however, but a most direct analytical result deduced fromthe principle theoretical beginnings and the empirical observations of both the Theory of Dependence and Peripheral Capitalism. Although the review vents its criticism on (and mainly questions the practicality of the aforesaid conception, a more penetratingunderstanding of what the wager for such a strategy entails is found. Thus, the notion of self-centered development influences and gives impulse to a most extensive ideologicallymarked debate about the alternative conceptions of development.

  16. Heritage Conservation and Urban Landscaping of Ancient Pan Pool Neighborhood, Qufu: a Historical and Indigenous Perspective

    Directory of Open Access Journals (Sweden)

    Yingchun Zhang


    Full Text Available Gu Pan Pool neighborhood got its name because of Gu Pan Chi, (古泮池,the ancient Pan Pool, located in the southeastern part of Confucius’ birthplace, Qufu, the birth place of Confucius with a history of 3000 year. Gu Pan Pool has been recently under preservation with the joint efforts of World Bank cultural heritage conservation project and the local municipal government. With disparate interests in mind, the three stakeholders of heritage, the world bank, Qufu municipal government and local residents are contradictory with each other in the regeneration process, in which the local voices are often ignored. The purpose of this paper is to rethink heritage making from a historical and indigenous perspective in the contemporary Chinese urban historic landscape planning process. The author contends that the cultural value and pluralism embedded in the ritual way of thinking in Chinese Classics inherited and transmitted for thousands of years could be an alternative way of thinking for the landscape planning practices in the homogenizing culture of global capitalism. This research aims to reinterpret and re-activate Confucianism as cultural heritage to enrich the understanding and hence the sustainability related to human action in urban spaces with emphasis on planning processes in contemporary China.

  17. Economic Mentalities And Present Day Values In Romanian Business Higher Education. A Historical Perspective

    Directory of Open Access Journals (Sweden)

    Maria MURESAN


    Full Text Available Mentalities and behaviours are the result of the interactions between persons/groups and the environment. The present paper explores the way mentalities and behaviours have been created by and have themselves determined the economic, social and political processes on the present day Romanian territory at the end of the 19th and the beginning of the 20th centuries. A historical perspective to the study of mentalities shows that the adaptation of a certain mindset, of the mainstream values characteristic of an epoch, to the changes in the evolution of the economy and society was also responsible for preparing the changes in the development of the economy. The present paper explores the differences between economic and business mentalities of people belonging to developed and emerging market economies by considering their historical development. The paper looks at the importance of the presence in the curriculum of business schools of the history of economy and/or of economic thought disciplines in order to help Romanian business higher education become a driving force in changing present day mentalities into values that pro-actively help Romanian students to become effective employees on the globalized labour markets.

  18. On the origins and the historical roots of the Higgs boson research from a bibliometric perspective (United States)

    Barth, A.; Marx, W.; Bornmann, L.; Mutz, R.


    The subject of our present paper is the analysis of the origins or historical roots of the Higgs boson research from a bibliometric perspective, using a segmented regression analysis in combination with a method named reference publication year spectroscopy (RPYS). Our analysis is based on the references cited in the Higgs boson publications published since 1974. The objective of our analysis consists of identifying specific individual publications in the Higgs boson research context to which the scientific community frequently had referred to. We are interested in seminal works which contributed to a high extent to the discovery of the Higgs boson. Our results show that researchers in the Higgs boson field preferably refer to more recently published papers —particularly papers published since the beginning of the sixties. For example, our analysis reveals seven major contributions which appeared within the sixties: Englert and Brout (1964), Higgs (1964, 2 papers), and Guralnik et al. (1964) on the Higgs mechanism as well as Glashow (1961), Weinberg (1967), and Salam (1968) on the unification of weak and electromagnetic interaction. Even if the Nobel Prize award highlights the outstanding importance of the work of Peter Higgs and Francois Englert, bibliometrics offer the additional possibility of getting hints to other publications in this research field (especially to historical publications), which are of vital importance from the expert point of view.

  19. Record Rainfall and Flooding in Texas and Oklahoma, May 2015; Extent and Historical Perspective (United States)

    Cepeda, J. C.


    Heavy rains began in Texas and Oklahoma in early May 2015 and continued through the end of the month. Both states set all-time records for mean statewide precipitation; Texas - 227mm (8.93 in), Oklahoma - 357mm (14.06 in) -- for the period of record (1895-2015). These new statewide records were set despite the fact that the western portions of both Texas and Oklahoma received only modest rainfall. Parameters used in this study to evaluate the magnitude and historical perspective of the May 2015 rainfall included daily and total storm precipitation, stream flow, changes in the Palmer Drought Severity Index (PDSI), and changes in reservoir water levels. Although the Dallas-Fort Worth area and the cities of Austin, Houston and Oklahoma City sustained the most serious flood events, more than 100 localities in the two states reported some flooding. The region with the largest amounts of precipitation extended from north-central Texas northeastward into eastern Oklahoma. Cumulative May rainfall in this region exceeded 508 mm (20 in). Provisional stream flow data for the river basins most affected -- Red River, Brazos, Colorado, and Trinity rivers -- reveal significant peaks, but the peaks generally are within the ranges of the historical record. With the exception of the Red River the most significant flooding relative to historic flood peaks, occurred on tributaries to the major rivers. Comparison of the PDSI for the months of April and June reveals the dramatic impact of the precipitation during May. By the first week of June both states are classified as moderately moist - with the exception of the extreme northeastern corner of Oklahoma. Changes in Reservoir levels (as a percent of capacity) between April and June was greatest for the Rolling Plains region (+ 15.5%), with lesser, but significant gains in South and Central Texas and the Central Oklahoma region.

  20. Stress and fish reproduction: the roles of allostasis and hormesis. (United States)

    Schreck, Carl B


    This paper is a review of the effects of stress on reproduction in fishes. I hope to further the development of the concepts of allostasis and hormesis as relevant to understanding reproduction in general and in fish in particular. The main contentions I derive in this review are the following: Stressors affect fish reproduction in a variety of ways depending on the nature and severity of the stressor. The effects are transduced through a hormonal cascade initiated by perception of the stressor and involving the hypothalamus-pituitary-interrenal axis, the catecholamines, and also cytokines. Mounting a stress response and resisting a stressor is an energetically costly process, including costs associated with allostasis, attempting to reset homeostatic norms. Responses in emergency situations (e.g., being chased by a predator or a net) can be different from those where fish can cope (e.g., being in a more crowded environment) with a stressor, but both situations involve energy re-budgeting. Emergency responses happen in concert with the onset of energy limitations (e.g., the fish may not eat), while coping with allostatic overload can happen in a more energy-rich environment (e.g., the fish can continue to eat). Low levels of stress may have a positive effect on reproductive processes while greater stress has negative effects on fish reproduction. The concept of hormesis is a useful way to think about the effect of stressors on fish reproduction since responses can be nonmonotonal, often biphasic.

  1. A Historical Perspective on Primary and Possible Secondary Sources of Atmospheric Carbon Tetrachloride (United States)

    Singh, Hanwant B.


    Atmospheric sources of Carbon Tetrachloride (CTC) have been controversial since its detection in the early 1970. Initial proposals were that it is globally uniformly distributed and its lack of current emissions and inferred lifetime indicated that it was likely of natural origin. Historical analysis of CTC use and emissions showed that atmospheric CTC was long-lived and mainly of man-made origin although small natural sources and sinks (e. g. oceans) could not be ruled out. This deduction was hard because a majority of emissions had occurred in early part of the 20th century when CTC was commonly used as a fumigant, a solvent, and a raw material for the manufacture of many chemicals. In the 1940's adverse health effects of exposure to CTC became evident and its emissions were greatly curtailed and substituted with C2Cl4 which was thought to be much safer. There were smog chamber studies that showed that C2Cl4, a widely used solvent during the late 20th century, could produce CTC with up to a 7% yield. Subsequently it was discovered that this chemistry probably required Cl atoms and since Cl atoms were not abundant in the atmosphere actual yields based on OH oxidation were probably closer to 0.1%. CTC was subsequently banned by the Montreal Protocol to prevent stratospheric ozone depletion and its preferred substitute C2Cl4 was also banned by EPA for reasons of potential carcinogenicity and toxicity. CTC since has been measured in many airborne NASA campaigns in which plumes have been sampled from a variety of regions which may still be emitting CTC. I will briefly discuss this historical perspective of CTC and show some recent data that may shed light on its current sources or lack there off.

  2. Stress to the Rescue: Is Hormesis a ‘Cure’ For Aging?

    DEFF Research Database (Denmark)

    Kahn, Arnold; Olsen, Anders


    Despite the fact that the phenomenon of hormesis has been known for many years it is still very much an area of controversy just how useful hormetic treatments are in preventing age-related human diseases and increasing life expectancy. Since there are no data in humans demonstrating hormesis as ...... as an effective anti-ageing strategy we turn to a simple model organism for insight. In this review we explore what can be predicted about the usefulness of hormetic treatments in humans based upon studies conducted in the soil nematode Caenorhabditis elegans.......Despite the fact that the phenomenon of hormesis has been known for many years it is still very much an area of controversy just how useful hormetic treatments are in preventing age-related human diseases and increasing life expectancy. Since there are no data in humans demonstrating hormesis...

  3. Thinking Historically, Teaching Historically: Perspectives on the Professional Development of Teachers from a Teaching American History Grant (United States)

    Sheets, Kevin B.


    In teacher's idealized history classroom, students are abuzz with questions. They are eager to jump into a serious analysis of primary sources. They relish additional opportunities to engage historiographical debates. They are, as teachers like to say, "thinking historically." While there are few easy ways to create these idealized…

  4. Resurgence of malaria in Bombay (Mumbai) in the 1990s: a historical perspective. (United States)

    Kamat, V


    Bombay has achieved extraordinary success in controlling its malaria problem for nearly six decades by relying primarily on legislative measures and non-insecticidal methods of mosquito abatement. In 1992, however, malaria reemerged in Bombay with a vengeance. During 1992-1997, the city witnessed a manifold increase in the number of malaria cases diagnosed and treated by the public health system. The large number of malaria patients treated by private practitioners was not recorded by the municipal malaria surveillance system during this period. In 1995, at the peak of the resurgence, public health officials of the Municipal Corporation of Greater Bombay (MCGB) confirmed that 170 persons in the city had died due to malaria. The crisis was unprecedented in Bombay's modern public health history. In response to intense criticism from the media, the city's public health officials attributed the resurgence to the global phenomenon of mosquito-vector resistance to insecticides, and Plasmodium resistance to antimalarial chemoprophylaxis and treatment. Local scientists who investigated the problem offered no support to this explanation. So what might explain the resurgence? What factors led the problem to reach an epidemic level in a matter of two or three years? In addressing the above principal questions, this paper adopts a historical perspective and argues that in the resurgence of malaria in Bombay in the 1990s, there is an element of the 'presence of the past'. In many ways the present public health crisis in Bombay resembles the health scenario that characterized the city at the turn of the 19th century. It is possible to draw parallels between the early public health history of malaria control in Bombay, which was punctuated by events that followed the bubonic plague epidemic of 1896, and the present-day malaria epidemic punctuated by the threat of a plague epidemic in 1994. As such, the paper covers a long period, of almost 100 years. This time-depth is used to

  5. A cultural historical theoretical perspective of discourse and design in the science classroom (United States)

    Adams, Megan


    Flavio Azevedo, Peggy Martalock and Tugba Keser have initiated an important conversation in science education as they use sociocultural theory to introduce design based scenarios into the science classroom. This response seeks to expand Azevedo, Martalock and Keser's article The discourse of design- based science classroom activities by using a specific perspective within a sociocultural framework. Through using a cultural historical (Vygotsky in The history and development of higher mental functions, Plenum Press, New York, 1987) reading of design based activity and discourse in the science classroom, it is proposed that learning should be an integral part of these processes. Therefore, everyday and scientific concepts are explained and expanded in relation to Inventing Graphing and discourse presented in Azevedo, Martalock and Keser's article. This response reports on the importance of teacher's being explicit in relation to connecting everyday and scientific concepts alongside design based activity and related science concepts when teaching students. It is argued that explicit teaching of concepts should be instigated prior to analysis of discourse in the science classroom as it is only with experience and understanding these processes that students have the resources to call upon to argue like practicing scientists.

  6. Analysing young children’s thinking about natural phenomena: A sociocultural/cultural historical perspective

    Directory of Open Access Journals (Sweden)



    Full Text Available Vygotsky’s sociocultural/cultural historical theory emphasised the notion of semiotic mediation – or how thinking is transformed through signs (such as language and cultural tools (such as drawings from an intermental to an intramental plane. While the ideas of Vygotsky have become well-accepted within research in early childhood education in Australia, they are somewhat slower to be adopted within science education research. Yet they offer the potential for gaining new understandings of how young children’s thinking about the world develops. This article will demonstrate one way in which aspects of Vygotsky’s (1987-1999 work, particularly his ideas about semiotic mediation can inform analysis of children’s thinking about the world. Focusing on conversations with children about natural phenomena, and drawings they completed during those conversations, the analysis identifies a number of significant issues that are not normally revealed within the dominant forms of analysis which draw on constructivist perspectives. The findings, which reveal complex and dynamic aspects of children’s thinking, have implications for both teachers and researchers working with young children – especially within science education and science education research.

  7. Cultural politics and masculinities: multiple-partners in historical perspective in KwaZulu-Natal. (United States)

    Hunter, Mark


    Drawing from ethnographic, archival and secondary research, this article examines multiple-sexual partners in historical perspective in KwaZulu-Natal, a South Africa province where one in three people are thought to be HIV positive. Research on masculinities, multiple partners, and AIDS has been predominantly directed towards the present day. This article stresses the importance of unraveling the antecedents of contemporary masculinities particularly the gendered cultural politics through which they have been produced. Arguing against dominant conceptions of African masculinity as being innate or static, it charts the rise and fall of the isoka, the Zulu man with multiple-sexual partners, over the last century. Showing how the isoka developed through changing conditions occasioned by capitalism, migrant labor and Christianity, it contends that an important turning point took place from the 1970s when high unemployment threatened previous expressions of manliness, notably marriage, settings up an independent household and becoming umnumzana (a household head). The high value placed on men seeking multiple-partners increasingly filled the void left by men's inability to become men through previous means. Turning to the contemporary period, the articles argues that, shaken by the huge AIDS deaths, men are betraying increasing doubts about the isoka masculinity.

  8. Profiles in chemistry: a historical perspective on the national organic symposium. (United States)

    Fenlon, Edward E; Myers, Brian J


    This perspective delineates the history of the National Organic Chemistry Symposium (NOS) and, in doing so, traces the development of organic chemistry over the past 88 years. The NOS is the premier event sponsored by the ACS Division of Organic Chemistry (ORGN) and has been held in odd-numbered years since 1925, with the exceptions of 1943 and 1945. During the 42 symposia, 332 chemists have given 549 plenary lectures. The role the NOS played in the launch of The Journal of Organic Chemistry and Organic Reactions and the initiation of the Roger Adams Award are discussed. Representative examples highlighting the chemistry presented in each era are described, and the evolution of the field is examined by assigning each NOS talk to one of seven subdisciplines and analyzing how the number of talks in each subdiscipline has changed over time. Comparisons of the demographics of speakers, attendees, and ORGN members are made, and superlatives are noted. Personal interest stories of the speakers are discussed, along with the relationships among them, especially their academic lineage. Logistical aspects of the NOS and their historical trends are reviewed. Finally, the human side of science is examined, where over the past century, the NOS has been intertwined with some of the most heated debates in organic chemistry. Conflicts and controversies involving free radicals, reaction mechanisms, and nonclassical carbocations are discussed.

  9. Teaching a changing paradigm in physiology: a historical perspective on gut interstitial cells. (United States)

    Drumm, Bernard T; Baker, Salah A


    The study and teaching of gastrointestinal (GI) physiology necessitates an understanding of the cellular basis of contractile and electrical coupling behaviors in the muscle layers that comprise the gut wall. Our knowledge of the cellular origin of GI motility has drastically changed over the last 100 yr. While the pacing and coordination of GI contraction was once thought to be solely attributable to smooth muscle cells, it is now widely accepted that the motility patterns observed in the GI tract exist as a result of a multicellular system, consisting of not only smooth muscle cells but also enteric neurons and distinct populations of specialized interstitial cells that all work in concert to ensure proper GI functions. In this historical perspective, we focus on the emerging role of interstitial cells in GI motility and examine the key discoveries and experiments that led to a major shift in a paradigm of GI physiology regarding the role of interstitial cells in modulating GI contractile patterns. A review of these now classic experiments and papers will enable students and educators to fully appreciate the complex, multicellular nature of GI muscles as well as impart lessons on how shifting paradigms in physiology are fueled by new technologies that lead to new emerging discoveries.

  10. The Canadian Management of Bovine Spongiform Encephalopathy in Historical and Scientific Perspective, 1990-2014. (United States)

    Quimby, Alexandra E; Shamy, Michel C F


    On February 11, 2015, the Canadian Food Inspection Agency announced that a cow born and raised in Alberta had tested positive for bovine spongiform encephalopathy (BSE), commonly known as mad cow disease. BSE is a prion disease of cattle that, when transmitted to humans, produces a fatal neurodegenerative disease known as variant Creutzfeldt-Jakob disease. We believe that this latest case of BSE in Canadian cattle suggests the timeliness of a review of the management of BSE in Canada from a historically and scientifically informed perspective. In this article, we ask: how did the Canadian management of BSE between 1990 and 2014 engage with the contemporary understanding of BSE's human health implications? We propose that Canadian policies largely ignored the implicit medical nature of BSE, treating it as a purely agricultural and veterinary issue. In this way, policies to protect Canadians were often delayed and incomplete, in a manner disturbingly reminiscent of Britain's failed management of BSE. Despite assurances to the contrary, it is premature to conclude that BSE (and with it the risk of variant Creutzfeldt-Jakob disease) is a thing of Canada's past: BSE remains very much an issue in Canada's present.

  11. Mitochondrial stress extends lifespan in C. elegans through neuronal hormesis. (United States)

    Maglioni, Silvia; Schiavi, Alfonso; Runci, Alessandra; Shaik, Anjumara; Ventura, Natascia


    Progressive neuronal deterioration accompanied by sensory functions decline is typically observed during aging. On the other hand, structural or functional alterations of specific sensory neurons extend lifespan in the nematode Caenorhabditis elegans. Hormesis is a phenomenon by which the body benefits from moderate stress of various kinds which at high doses are harmful. Several studies indicate that different stressors can hormetically extend lifespan in C. elegans and suggest that hormetic effects could be exploited as a strategy to slow down aging and the development of age-associated (neuronal) diseases in humans. Mitochondria play a central role in the aging process and hormetic-like bimodal dose-response effects on C. elegans lifespan have been observed following different levels of mitochondrial stress. Here we tested the hypothesis that mitochondrial stress may hormetically extend C. elegans lifespan through subtle neuronal alterations. In support of our hypothesis we find that life-lengthening dose of mitochondrial stress reduces the functionality of a subset of ciliated sensory neurons in young animals. Notably, the same pro-longevity mitochondrial treatments rescue the sensory deficits in old animals. We also show that mitochondrial stress extends C. elegans lifespan acting in part through genes required for the functionality of those neurons. To our knowledge this is the first study describing a direct causal connection between sensory neuron dysfunction and extended longevity following mitochondrial stress. Our work supports the potential anti-aging effect of neuronal hormesis and open interesting possibility for the development of therapeutic strategy for age-associated neurodegenerative disorders.

  12. Controlling our destinies: Historical, philosophical, social and ethical perspectives on the Human Genome Project: Final report, July 1, 1995-June 30, 1996

    Energy Technology Data Exchange (ETDEWEB)

    Sloan, P.R.


    This report briefly describes the efforts by the organizing committee in preparation for the conference entitled Controlling Our Destinies: Historical, Philosophical, Social, and Ethical Perspectives on the Human Genome Project. The conference was held October 5-8, 1995.

  13. Modelling and simulation of dielectric heterostructures: a physical survey from an historical perspective

    Energy Technology Data Exchange (ETDEWEB)

    Brosseau, Christian [Laboratoire d' Electronique et Systemes de Telecommunications and Departement de Physique, Universite de Bretagne Occidentale, CS 93837, 6 avenue Le Gorgeu, 29238 Brest Cedex 3 (France)


    Basic physical concepts and theoretical ideas concerning dielectric heterostructures are reviewed from a historical perspective. This background for today's theory of dielectric heterostructures is discussed in some detail because the guiding principles for our understanding can be traced to the earliest developments in electromagnetism. To give an impression of the accelerating progress, I shall distinguish five stages in the development of our understanding of the dielectric properties of heterostructures. Historical remarks are included and technical concepts are introduced informally. For each stage, I call attention to synthetic works or compendia created during the interval. The first stage was reached towards the second half of the 19th century with the work of James Clerk Maxwell. Next the second stage was initiated by Bruggeman through the concept of an effective medium. Bounding methods form the third stage, with many investigators involved, beginning with the work of Wiener; the importance and ingenuity of these methods cannot be overstated. The fourth stage was the introduction of the crucial concept of percolation through an infinite cluster of connected particles and the modern approach to criticality which began in the mid-20th century with the work of Broadbent and Hammersley. Finally, the fifth stage we have experienced in the last decades involves the rapidly developing subject of computational electromagnetics: computers have moved the emphasis away from the general theory of macroscopic electromagnetism towards a better look at the detailed features of the randomness and connectedness of heterostructures. It is concluded that computational techniques provide a versatile tool for studying the dielectric properties of complex composite materials and that considerable progress can be achieved by comparing numerical results against analytical predictions for the properties of these models. As the capabilities for performing realistic

  14. Ringhals unit 3 and 4 - Fluence determination in a historic and future perspective

    Energy Technology Data Exchange (ETDEWEB)

    Green, E.L. [Primary Systems Inspection and Repair, Vattenfall/Ringhals AB, 432 85 Vaeroebacka (Sweden); Rouden, J. [Material and Analytical Services, Vattenfall/Ringhals AB, 432 85 Vaeroebacka (Sweden); Efsing, P. [Materials Mechanics, Research and Nuclear Development, Vattenfall/Ringhals AB, 432 85 Vaeroebacka (Sweden)


    Document available in abstract form only, full text of document follows: The Ringhals site is situated on the Swedish southwest coastline. At the site, there are four operating nuclear power plants. Historically, the Swedish policy has been that the nuclear power plants were to be closed in 2010. The present position is to operate the units until their technical and economic lifetime has run out. The units shall be maintained and invested in to ensure a lifetime of at least 50 years, but the actions taken shall not limit the time to this date. When the initial surveillance capsules were evaluated, it was noted that the material properties of the weld material of unit 3 and 4 showed some deviations from the expected behaviour. Currently there is an extensive project running for re-evaluating the embrittlement situation from a long-term operating perspective. One part of the project is aimed at more accurately determining the fluence levels of the reactor pressure vessels (RPVs). The basis for the early evaluations of the dosimeters in the surveillance capsules and the corresponding fluence evaluation had an operating lifetime of 25 years as a target value. Therefore, the accuracy and refinement of the measurement and calculation were taken to be good enough to suit this life span. Looking back at the results from the dosimetry measurements there are a few discrepancies. Some of the dosimeters were disintegrated and some measurements had comparatively large uncertainties. When starting this project there were some re-evaluations done with the old fluence prediction model. For every new run and refinement there appeared new difficulties, and the decision was to start the evaluation from scratch. Then there are two questions remaining regarding the fluence: What is the current fluence level? What will the resulting fluence be after 60 years of operation, when we have up-rated output power of both reactors? This paper aims to describe the view of the fluence evaluation

  15. Human embryonic stem cell cultivation: historical perspective and evolution of xeno-free culture systems. (United States)

    Desai, Nina; Rambhia, Pooja; Gishto, Arsela


    Human embryonic stem cells (hESC) have emerged as attractive candidates for cell-based therapies that are capable of restoring lost cell and tissue function. These unique cells are able to self-renew indefinitely and have the capacity to differentiate in to all three germ layers (ectoderm, endoderm and mesoderm). Harnessing the power of these pluripotent stem cells could potentially offer new therapeutic treatment options for a variety of medical conditions. Since the initial derivation of hESC lines in 1998, tremendous headway has been made in better understanding stem cell biology and culture requirements for maintenance of pluripotency. The approval of the first clinical trials of hESC cells for treatment of spinal cord injury and macular degeneration in 2010 marked the beginning of a new era in regenerative medicine. Yet it was clearly recognized that the clinical utility of hESC transplantation was still limited by several challenges. One of the most immediate issues has been the exposure of stem cells to animal pathogens, during hESC derivation and during in vitro propagation. Initial culture protocols used co-culture with inactivated mouse fibroblast feeder (MEF) or human feeder layers with fetal bovine serum or alternatively serum replacement proteins to support stem cell proliferation. Most hESC lines currently in use have been exposed to animal products, thus carrying the risk of xeno-transmitted infections and immune reaction. This mini review provides a historic perspective on human embryonic stem cell culture and the evolution of new culture models. We highlight the challenges and advances being made towards the development of xeno-free culture systems suitable for therapeutic applications.


    Directory of Open Access Journals (Sweden)

    Hamka Siregar


    Full Text Available The momentum of the development of Sharia banking has been noticed since the 1970s, which generally had two patterns: first, establishing the Islamic bank side by side with conventional one (dual-banking system as practiced in Egypt, Malaysia, Saudi Arabia, Jordan, Kuwait, Bahrain, and Bangladesh; and second, restructuring the banking system as a whole in accordance with Islamic Sharia (full-fledged Islamic financial system as applied in Sudan, Iran and Pakistan. The development of the Sharia-based banks which have been established across the world since the 1970s, became the motivation of the Indonesian ulemas to draft law on Sharia banking, so that Sharia banking could also be developed. As a result, these last few years, the banking world in Indonesia has witnessed the establishment of the public Sharia banks and Sharia business units, like Bank Muamalat and Bank Syariah Mandiri to mention a few. Using historical and contemporary jurisprudence perspective, this paper provides discussion on the future of Sharia banking.

  17. Myofascial Trigger Points Then and Now: A Historical and Scientific Perspective. (United States)

    Shah, Jay P; Thaker, Nikki; Heimur, Juliana; Aredo, Jacqueline V; Sikdar, Siddhartha; Gerber, Lynn


    The intent of this article is to discuss the evolving role of the myofascial trigger point (MTrP) in myofascial pain syndrome (MPS) from both a historical and scientific perspective. MTrPs are hard, discrete, palpable nodules in a taut band of skeletal muscle that may be spontaneously painful (i.e., active) or painful only on compression (i.e., latent). MPS is a term used to describe a pain condition that can be acute or, more commonly, chronic and involves the muscle and its surrounding connective tissue (e.g. fascia). According to Travell and Simons, MTrPs are central to the syndrome-but are they necessary? Although the clinical study of muscle pain and MTrPs has proliferated over the past two centuries, the scientific literature often seems disjointed and confusing. Unfortunately, much of the terminology, theories, concepts, and diagnostic criteria are inconsistent, incomplete, or controversial. To address these deficiencies, investigators have recently applied clinical, imaging (of skeletal muscle and brain), and biochemical analyses to systematically and objectively study the MTrP and its role in MPS. Data suggest that the soft tissue milieu around the MTrP, neurogenic inflammation, sensitization, and limbic system dysfunction may all play a role in the initiation, amplification, and perpetuation of MPS. The authors chronicle the advances that have led to the current understanding of MTrP pathophysiology and its relationship to MPS, and review the contributions of clinicians and researchers who have influenced and expanded our contemporary level of clinical knowledge and practice.

  18. Effect of Photon Hormesis on Dose Responses to Alpha Particles in Zebrafish Embryos

    Directory of Open Access Journals (Sweden)

    Candy Yuen Ping Ng


    Full Text Available Photon hormesis refers to the phenomenon where the biological effect of ionizing radiation with a high linear energy transfer (LET value is diminished by photons with a low LET value. The present paper studied the effect of photon hormesis from X-rays on dose responses to alpha particles using embryos of the zebrafish (Danio rerio as the in vivo vertebrate model. The toxicity of these ionizing radiations in the zebrafish embryos was assessed using the apoptotic counts at 20, 24, or 30 h post fertilization (hpf revealed through acridine orange (AO staining. For alpha-particle doses ≥ 4.4 mGy, the additional X-ray dose of 10 mGy significantly reduced the number of apoptotic cells at 24 hpf, which proved the presence of photon hormesis. Smaller alpha-particle doses might not have inflicted sufficient aggregate damages to trigger photon hormesis. The time gap T between the X-ray (10 mGy and alpha-particle (4.4 mGy exposures was also studied. Photon hormesis was present when T ≤ 30 min, but was absent when T = 60 min, at which time repair of damage induced by alpha particles would have completed to prevent their interactions with those induced by X-rays. Finally, the drop in the apoptotic counts at 24 hpf due to photon hormesis was explained by bringing the apoptotic events earlier to 20 hpf, which strongly supported the removal of aberrant cells through apoptosis as an underlying mechanism for photon hormesis.

  19. Effect of Photon Hormesis on Dose Responses to Alpha Particles in Zebrafish Embryos (United States)

    Ng, Candy Yuen Ping; Cheng, Shuk Han; Yu, Kwan Ngok


    Photon hormesis refers to the phenomenon where the biological effect of ionizing radiation with a high linear energy transfer (LET) value is diminished by photons with a low LET value. The present paper studied the effect of photon hormesis from X-rays on dose responses to alpha particles using embryos of the zebrafish (Danio rerio) as the in vivo vertebrate model. The toxicity of these ionizing radiations in the zebrafish embryos was assessed using the apoptotic counts at 20, 24, or 30 h post fertilization (hpf) revealed through acridine orange (AO) staining. For alpha-particle doses ≥ 4.4 mGy, the additional X-ray dose of 10 mGy significantly reduced the number of apoptotic cells at 24 hpf, which proved the presence of photon hormesis. Smaller alpha-particle doses might not have inflicted sufficient aggregate damages to trigger photon hormesis. The time gap T between the X-ray (10 mGy) and alpha-particle (4.4 mGy) exposures was also studied. Photon hormesis was present when T ≤ 30 min, but was absent when T = 60 min, at which time repair of damage induced by alpha particles would have completed to prevent their interactions with those induced by X-rays. Finally, the drop in the apoptotic counts at 24 hpf due to photon hormesis was explained by bringing the apoptotic events earlier to 20 hpf, which strongly supported the removal of aberrant cells through apoptosis as an underlying mechanism for photon hormesis. PMID:28208665

  20. Stopping the "Flow of Co-Eds and Other Female Species": A Historical Perspective on Gender Discrimination at Southern (U.S.) Colleges and Universities (United States)

    McCandless, Amy Thompson


    The interrelated nature of gender and racial constructs in the culture of the southern United States accounts for much of the historical prejudice against coeducation in the region's institutions of higher education. This essay offers a historical perspective on gender discrimination on the campuses of Southern universities from the attempts to…

  1. Hormesis does not make sense except in the light of TOR-driven aging. (United States)

    Blagosklonny, Mikhail V


    Weak stresses (including weak oxidative stress, cytostatic agents, heat shock, hypoxia, calorie restriction) may extend lifespan. Known as hormesis, this is the most controversial notion in gerontology. For one, it is believed that aging is caused by accumulation of molecular damage. If so, hormetic stresses (by causing damage) must shorten lifespan. To solve the paradox, it was suggested that, by activating repair, hormetic stresses eventually decrease damage. Similarly, Baron Munchausen escaped from a swamp by pulling himself up by his own hair. Instead, I discuss that aging is not caused by accumulation of molecular damage. Although molecular damage accumulates, organisms do not live long enough to age from this accumulation. Instead, aging is driven by overactivated signal-transduction pathways including the TOR (Target of Rapamycin) pathway. A diverse group of hormetic conditions can be divided into two groups. "Hormesis A" inhibits the TOR pathway. "Hormesis B" increases aging-tolerance, defined as the ability to survive catastrophic complications of aging. Hormesis A includes calorie restriction, resveratrol, rapamycin, p53-inducing agents and, in part, physical exercise, heat shock and hypoxia. Hormesis B includes ischemic preconditioning and, in part, physical exercise, heat shock, hypoxia and medical interventions.

  2. Structured Development and Promotion of a Research Field: Hormesis in Biology, Toxicology, and Environmental Regulatory Science. (United States)

    Mushak, Paul; Elliott, Kevin C


    The ability of powerful and well-funded interest groups to steer scientific research in ways that advance their goals has become a significant social concern. This steering ability is increasingly being recognized in the peer-reviewed scientific literature and in findings of deliberative scientific bodies. This paper provides a case study that illustrates some of the major strategies that can be used to structure and advance a controversial research field. It focuses on hormesis, described as a type of dose-response relationship in toxicology and biology showing low-dose stimulation but high-dose inhibition, or the reverse. Hormesis proponents tout its significance, arguing that substances toxic at high doses and beneficial at lower doses should be regulated less stringently. We identify five strategies employed by hormesis proponents to foster its acceptance: (1) creating institutions focused on supporting hormesis; (2) developing terminology, study designs, and data interpretations that cast it in a favorable light; (3) using bibliometric techniques and surveys to attract attention; (4) aggressively advocating for the phenomenon and challenging critics; and (5) working with outside interest groups to apply the hormesis phenomenon in the economic and political spheres. We also suggest a number of oversight strategies that can be implemented to help promote credible and socially responsible research in cases like this one.

  3. Poseidon's paintbox : historical archives of ocean colour in global-change perspective (United States)

    Wernand, M. R.


    In the thesis introduction issues are discussed on the historical background of marine optics and on marine optical devices that were used over the past centuries to observe and measure; as in all sciences, in marine optics we can see a steady development: that of ‘measuring’, beginning many centuries ago, to 'knowing' and since less than a century to the understanding of the phenomenon. Hereafter, six themes are treated successively. The first theme, ‘Ocean optics from 1600 (Hudson) to 1930 (Raman), shift in interpretation of natural water colouring’, addresses the question of why it took so long a time to explain the phenomenon ‘the colouring of the sea’, especially the blue colour, despite the age-long interest of sailors, for practical purposes of navigation and detection of fish - of which more later. The second theme ‘On the history of the Secchi disc’, describes the search to establish methods for the determination of (sea) water clarity concerning purposes of navigation (near coast colour changes) just mentioned to detect shoals, and for a more basic purpose, tracing lost objects. The search to determine the clarity of lakes and seas culminated in the invention of the Secchi disc, used since the late 19th century. The third theme, ‘Spectral analysis of the Forel-Ule ocean colour comparator scale’, addresses the accuracy of a colour scale proposed, used in limnology and oceanography. Scale observations are put into perspective with contemporary measurements on the colour of the sea. The fourth theme, ‘Ocean colour changes in the North Pacific since 1930’, handles the question whether long-term ocean colour changes using historic Forel-Ule observations, in this part of the ocean made very frequently over time, can be determined in relation to global change. In principal global warming may cause a gradual change in ocean colour due to the effect of biological, chemical and physical aspects of the ocean-surface. The fifth theme,

  4. What are check dams made for? An historical perspective from the French experience (United States)

    Piton, Guillaume; Carladous, Simon; Recking, Alain


    technical and sociological reasons. The Mountain lands' conservation and restoration law of 1882 aimed to better fit local issues. The idea of the presentation is thus to highlight how evolved the historical comprehension of torrential hazards and of the usefulness of check dams in mitigation plans in a changing environment on the technical as well as on the sociological and regulatory points of view. Pioneering scientific and technical works on torrential hydraulics and check dams will be presented. Describing the global context that leads to French laws of 1860,1864 and 1882 will allow us to explain the extensive development of the works in more than a thousand of torrents and a hundred of big landslides. We then will discuss the evolution of technics during the beginning of the 20th century and the changes induced after WWII by the arrival of reinforced-concrete technics. We will conclude the presentation with a synthesis table aiming to highlight the different functions of check dams based on a description of their situations in the watershed, compare to other structures' situations and on shape criteria. This historical perspective will hopefully help people to better understand for which purposes some structures have been built in the past centuries and what lessons can be learnt from this assessment.

  5. Choice of rotatable plug seals for prototype fast breeder reactor: Review of historical perspectives

    Energy Technology Data Exchange (ETDEWEB)

    Sinha, N.K., E-mail:; Raj, Baldev, E-mail:


    Highlights: • Choice and arrangement of elastomeric inflatable and backup seals as primary and secondary barriers. • With survey (mid-1930s onwards) of reactor, sealing, R&D and rubber technology. • Load, reliability, safety, life and economy of seals and reactors are key factors. • PFBR blends concepts and experience of MOX fuelled FBRs with original solutions. • R&D indicates inflatable seal advanced fluoroelastomer pivotal in unifying nuclear sealing. - Abstract: Choice and arrangement of elastomeric primary inflatable and secondary backup seals for the rotatable plugs (RPs) of 500 MW (e), sodium cooled, pool type, 2-loop, mixed oxide (MOX) fuelled Prototype Fast Breeder Reactor (PFBR) is depicted with review of various historical perspectives. Static and dynamic operation, largest diameters (PFBR: ∼6.4 m, ∼4.2 m), widest gaps and variations (5 ± 2 mm) and demanding operating requirements make RP openings on top shield (TS) the most difficult to seal which necessitated extensive development from 1950s to early 1990s. Liquid metal freeze seals with life equivalent to reactor prevailed as primary barrier (France, Japan, U.S.S.R.) during pre-1980s in spite of bulk, cost and complexity due to the abilities to meet zero leakage and resist core disruptive accident (CDA). Redefinition of CDA as beyond design basis accident, tolerable leakage and enhanced economisation drive during post-1980s established elastomeric inflatable seal as primary barrier excepting in U.S.S.R. (MOX fuel, freeze seal) and U.S.A. (metallic fuel). Choice of inflatable seal for PFBR RPs considers these perspectives, inherent advantages of elastomers and those of inflatable seals which maximise seal life. Choice of elastomeric backup seal as secondary barrier was governed by reliability and minimisation as well as distribution of load (temperature, radiation, mist) to maximise seal life. The compact sealing combination brings the hanging RPs at about the same elevation to reduce

  6. Proton pump inhibitor-responsive esophageal eosinophilia: a historical perspective on a novel and evolving entity

    Directory of Open Access Journals (Sweden)

    Javier Molina-Infante

    Full Text Available Eosinophilic esophagitis (EoE is an emerging chronic esophageal disease, first described in 1993, with a steadily increasing incidence and prevalence in western countries. Over the 80's and early 90's, dense esophageal eosinophilia was mostly associated gastroesophageal reflux disease (GERD. For the next 15 years, EoE and GERD were rigidly considered separate entities: Esophageal eosinophilia with pathological acid exposure on pH monitoring or response to proton pump inhibitor (PPI therapy was GERD, whereas normal pH monitoring or absence of response to PPIs was EoE. Updated guidelines in 2011 described a novel phenotype, proton pump inhibitor-responsive esophageal eosinophilia (PPI-REE, referring to patients who appear to have EoE clinically, but who achieve complete remission after PPI therapy. Currently, PPI-REE must be formally excluded before diagnosing EoE, since 30-40 % of patients with suspected EoE are eventually diagnosed with PPI-REE. Interestingly, PPI-REE and EoE remain undistinguishable based on clinical, endoscopic, and histological findings, pH monitoring, and measurement of tissue markers and cytokines related to eosinophilic inflammation. This review article aims to revisit the relatively novel concept of PPI-REE from a historical perspective, given the strong belief that only GERD, as an acid peptic disorder, could respond to the acid suppressing ability of PPI therapy, is becoming outdated. Evolving evidence suggests that PPI-REE is genetically and phenotypically undistinguishable from EoE and PPI therapy alone can almost completely reverse allergic inflammation. As such, PPI-REE might constitute a subphenotype of EoE and PPI therapy may be the first therapeutic step and diet/ steroids may represent step up therapy. Possibly, the term PPI-REE will be soon replaced by PPI-responsive EoE. The mechanism as to why some patients respond to PPI therapy (PPI-REE while others do not (EoE, remains to be elucidated.

  7. A historical perspective on precipitation, drought severity, and streamflow in Texas during 1951-56 and 2011 (United States)

    Winters, Karl E.


    The intense drought throughout Texas during 2011 resulted in substantial declines in streamflow. By April 2011, nearly all of the State was experiencing severe to extreme drought according to data from the University of Nebraska–Lincoln Drought Monitor. By the end of July 2011, more than 75 percent of the State was experiencing exceptional drought. The worst of the drought occurred around October 4, 2011, when 97 percent of Texas was suffering from extreme to exceptional drought. The historical drought of 1951–56 has long been used by water-resource managers, engineers, and scientists as a point of reference for water-supply planning. A comparison of drought conditions during the 2011 water year (October 1, 2010, through September 30, 2011) to the historical drought of 1951–56 from a hydrologic perspective serves as an additional reference for water-supply planning.

  8. Historical Facts and Fictions: Representing and Reading Diverse Perspectives on the Past. (United States)

    Enciso, Patricia E.; Jenkins, Christine; Rogers, Theresa; Tyson, Cynthia; Marshall, Elizabeth; Robinson, Dwan; Wissman, Jackie; Price-Dennis, Detra; Core, Elizabeth; Morss, Betty; Cordova, Carmen; Youngsteadt-Parish, Denise


    Presents brief descriptions of 22 recently published books for children and adolescents that present untold stories that begin to fill in the gaps of mainstream versions of the past. Includes categories of historical fiction, historical nonfiction, biography/memoir, and poetry and verse. Discusses these books in tandem with numerous landmark…

  9. The Inside, Out: Diaries as Entry Points to Historical Perspective-Taking (United States)

    Lemisko, Lynn


    Diaries can serve as meaningful entry points for advancing historical consciousness and develop historical thinking (Seixas, 2002) because they can connect readers/learners with the diverse emotions, thoughts and motivations of the people who wrote them in particular times and particular places. According to philosopher and historian, R.G.…

  10. A Dataset on Comparative Historical National Accounts, ca.1870-1950 : A Time-Series Perspective

    NARCIS (Netherlands)

    Smits, J.-P.; Woltjer, P.; Ma, D.


    This paper accompanies the Historical National Accounts datahub which presents an overview of the currently available studies on long-term economic growth across countries. Now that more and more detailed historical national accounts have become available, the Groningen Growth and Development Centre

  11. Social contract of academic medical centres to the community: Dr Howard Atwood Kelly (1858-1943), a historical perspective. (United States)

    Allen, Paul


    Academic medical centres have traditionally been bastions of teaching and research. Outreach to the community at large and involvement in community affairs have sometimes been lacking in the overall mission and activities of academic medical centres. This paper provides an historical perspective first on the numerous achievements of a physician and surgeon and then on the topic of involvement in community affairs by reviewing the many contributions of America's pioneer gynaecological surgeon and one of the four physician founders of the Johns Hopkins Hospital and School of Medicine in 1889 - Dr Howard Atwood Kelly.

  12. Constraints on the general solutions of Einstein cosmological equations by Hubble parameter times cosmic age: a historical perspective

    CERN Document Server

    Gonzalo, Julio A


    In a historical perspective, compact solutions of Einstein's equations, including the cosmological constant and the curvature terms, are obtained, starting from two recent observational estimates of the Hubble's parameter (H0) and the "age" of the universe (t0). Cosmological implications for {\\Lambda}CDM ({\\Lambda} Cold Dark Matter), KOFL (k Open Friedman-Lemaitre), plus two mixed solutions are investigated, under the constraints imposed by the relatively narrow current uncertainties. Quantitative results obtained for the KOFL case seem to be compatible with matter density and the highest observed red-shifts from distant galaxies, while those obtained for the {\\Lambda}CDM may be more difficult to reconcile.

  13. The territoriality of spatial-economic governance in historical perspective: the case of the Netherlands

    NARCIS (Netherlands)

    Lagendijk, A.; Boekema, F.W.M.


    This chapter explores how shifts in governmentality and the rise of new forms of governance in the field of regional innovation policies have impacted upon perspectives on territoriality and practices of territorialisation. The debate centres on two dominant perspectives, both endorsed by neo-libera

  14. Monitoring Colonial Waterbird Populations in the Northeast: Historical and Future Perspectives (United States)

    US Fish and Wildlife Service, Department of the Interior — In this paper the author documents both historical and current programs or activities affecting waterbird populations and their habitats in the Northeast, review...

  15. The Marine Engineers in Today’s MAGTF: Historical Perspective, Consequences and Alternatives (United States)


    responsive to the needs of the force. 1 INTRODUCTION “More than most professions , the military is forced to depend on intelligent... profession , the soldier makes maximum use of the historical record to function effectively in emergency. The facts derived from historical analysis, he...years of experience and broad exposure to varying mission sets. Senior officers and SNCOs in the utilities and hygiene support, heavy equipment

  16. "A terror to their neighbors": beliefs about mental disorder and violence in historical and cultural perspective. (United States)

    Monahan, J


    This tribute to the enduring legacy of Bernard Diamond explores public perceptions of a link between mental disorder and violent behavior. Research on contemporary American beliefs is summarized and compared both to historical accounts of public perceptions in Western cultures and to anthropological investigations of public perceptions in non-Western cultures. The conclusion of these reviews is that the belief that mental disorder bears some moderate association with violent behavior is both historically invariant and culturally universal.

  17. A Historical Perspective of Global Warming Potential from Municipal Solid Waste Management

    DEFF Research Database (Denmark)

    Habib, Komal; Schmidt, Jannick Højrup; Christensen, Per


    The Municipal Solid Waste Management (MSWM) sector has developed considerably during the past century, paving the way for maximum resource (materials and energy) recovery and minimising environmental impacts such as global warming associated with it. The current study is assessing the historical...... development of MSWM in the municipality of Aalborg, Denmark throughout the period of 1970 to 2010, and its implications regarding Global Warming Potential (GWP100), using the Life Cycle Assessment (LCA) approach. Historical data regarding MSW composition, and different treatment technologies...

  18. Ultraviolet radiation: questions of hazard, homeostasis, or hormesis?

    Energy Technology Data Exchange (ETDEWEB)

    Sliney, D. [USA Center for Health Promotion and Preventive Medicine, Gunpowder, MD (United States)


    The general approach taken when dealing with health issues arising from chronic human exposure to solar ultraviolet radiation appear to be quite different from that taken with the safety of human exposure to ionizing radiation. The public climate for accepting scientific risk assessments of human exposure appears to be markedly different for these two types of radiation exposures. Issues relating to setting exposure guidelines, such as dose response, with arguments over ''linear-no-threshold'' or ''hormesis,'' have engendered much debate and have severely challenged the development of a consensus on how to best control the health hazards from low-level ionizing radiation exposure. By contrast, these same questions are rarely raised in the public policy arena with regard to health policies for dealing with ultraviolet, non-ionizing radiation. Ultraviolet radiation exposure is a known carcinogen, but workers and the general public willingly expose themselves routinely to levels of ultraviolet radiation exceeding health exposure guidelines. Occupational health and safety advisors are constantly challenged on how to cope with exposure of the outdoor worker to the ultraviolet radiation in sunlight that can exceed health guidelines. A de facto consensus that permits workers to be exposed far above guidelines appears to exist because of the overwhelming public acceptance of the concept that ultraviolet radiation in sunlight has some benefit, despite the risk. A similar public perception generally does not exist for ionizing radiation, but are there similar risks? From a biophysical standpoint, the generally accepted target molecule is DNA and the single-hit theory would apply to both. Unlike ionizing radiation the target organs are limited to skin and eye. Furthermore, cancer of the eye in humans is virtually unknown; whereas, cancer of the skin is most common. It would be well to examine whether the potential for different outcomes

  19. [The proof of paternity. An andrological-forensic challenge in historical perspective]. (United States)

    Albrecht, K; Schultheiss, D


    For centuries, difficulties have occurred in determining unresolved paternities. In addition to the modern standard methods, such as the examination of DNA or serological proof, expert opinion on fertility once played an important role. The andrological difference between incapability to fertilise and the inability to participate in sexual intercourse was also distinguished historically. Of special significance was the discovery of spermatozoa by the medical student Johan Ham in 1677 and their further investigation by Antoni van Leeuwenhoek.Recently, modern DNA methods have also been applied for historical investigations. Illustrious examples are the DNA analysis in the case of Kaspar Hauser of Ansbach and the dispute about Thomas Jefferson, President of the U.S., fathering a child by one of his slaves. In this discourse, a medicinal-forensic review of the development of expert opinion, illustrated with historical case studies, is given.

  20. Hormesis-based anti-aging products: a case study of a novel cosmetic

    DEFF Research Database (Denmark)

    Rattan, Suresh; Kryzch, Valerie; Schnebert, Sylvianne


    and cosmeceuticals. Here we present the example of a skin care cosmetic as one of the first successful product developments incorporating the ideas of hormesis. This was based on the studies to analyse the molecular effects of active ingredients extracted from the roots of the Chinese herb Sanchi (Panax notoginseng......, nutritional and mental hormetins...

  1. Radiation hormesis. Stimulatory effects of low level ionizing radiation on plant

    Energy Technology Data Exchange (ETDEWEB)

    Kinoshita, Shigenobu; Masui, Hisashi; Yoshida, Shigeo; Murata, Isao [Osaka Univ., Suita (Japan). Faculty of Engineering


    Recently, the study for radiation hormesis has been executed against animals and plants; subharmful doses of radiation may evoke a stimulatory response in any organism. We executed irradiating experiments of dry seeds with fusion (D-T) neutron, fission neutron, cobalt-60 gamma-ray and investigated existence of the radiation hormesis effects by measuring germination, the length of a stalk and the total weight of a seed leaf on the 7th day after starting cultivation. And we estimated radiation hormesis effects by relative effectiveness, the ratio of the mean value of measurement subjects for the irradiated group to that of non-irradiated group. In relation to Raphanus sativus, the hormesis effects on seed leaf growth from irradiated seeds have only turned up in seed groups irradiated by the fusion (D-T) neutron. We have confirmed that absorbed dose range which revealed the effects is from 1 cGy to 10 Gy and the increasing rate is from 5 percent to 25 percent against a control group. (author)

  2. Model Uncertainty via the Integration of Hormesis and LNT as the Default in Cancer Risk Assessment

    Directory of Open Access Journals (Sweden)

    Edward J. Calabrese


    Full Text Available On June 23, 2015, the US Nuclear Regulatory Commission (NRC issued a formal notice in the Federal Register that it would consider whether “it should amend its ‘Standards for Protection Against Radiation’ regulations from the linear non-threshold (LNT model of radiation protection to the hormesis model.” The present commentary supports this recommendation based on the (1 flawed and deceptive history of the adoption of LNT by the US National Academy of Sciences (NAS in 1956; (2 the documented capacity of hormesis to make more accurate predictions of biological responses for diverse biological end points in the low-dose zone; (3 the occurrence of extensive hormetic data from the peer-reviewed biomedical literature that revealed hormetic responses are highly generalizable, being independent of biological model, end point measured, inducing agent, level of biological organization, and mechanism; and (4 the integration of hormesis and LNT models via a model uncertainty methodology that optimizes public health responses at 10−4. Thus, both LNT and hormesis can be integratively used for risk assessment purposes, and this integration defines the so-called “regulatory sweet spot.”

  3. Hiromeri: a specialty ham of Cyprus--historical evidence, culinary and cultural perspectives. (United States)

    Patapiou, Nasa; Lazarou, Chrystalleni


    Hiromeri is a specialty ham of Cyprus, made of smoked pork leg that is matured in wine. Until now there has been no systematic effort to present historical evidence that will support the Cypriot authenticity of this product. In this article, the historical evidence from sixteenth to twentieth centuries, referring to the production and trade of hiromeri in Cyprus, is presented. The evidence is drawn from archival testimony, travelers' descriptions, old history books, and essays on agricultural production. Moreover, a description of the hiromeri production process as well as past and current culinary uses and customs associated with its production and consumption are presented.

  4. On Narrative Strategies Embodied in The Known World under New His-torical Perspective

    Institute of Scientific and Technical Information of China (English)

    ZHANG Ying-ying; QIU Jia-ling


    With the multiple clues, rambling narrative and multidimensional architecture, Jones, in TheKnownWorld, constructs a fairly layered, three-dimensional world and presents a panorama of the entire slave society. The so-called mongline History be-fore is decomposed into a number of linear histories, and history which was non-narrative and non-representational is dismantled into histories narrated by many single narrators. Cultural discourse and historical discourse blend together. Jones shares the same conception on history and literature with New Historical critics who emphasize the complex mix-and-match interaction be-tween history and text.

  5. [A historical-epistemological perspective of the ontological problem of Positivism. Positivism and psychiatry]. (United States)

    Fantin, Juan Carlos


    The present article reviews epistemological problems related to the philosophical and scientific current known as Positivism. The revision begins with the study of the historical period during which the Logical Positivism emerges (early in the decade of 1920); and finishes with the analysis of its influence on psychiatry and its relation with other epistemological currents in the same period. The article reviews the historical and epistemological outlook at te beginning of the XX th century, when the problem of language became ontologically outstanding. The question of language remains important in the present discussions.

  6. Translating Bourdieu: cultural capital and the English middle class in historical perspective. (United States)

    Gunn, Simon


    This article examines the ways in which Pierre Bourdieu's work on culture and cultural capital can be applied to the study of the English middle class in the nineteenth and twentieth centuries. Drawing on a wide historical literature, the article argues for the significance of culture as a constitutive element of middle-class identities in England since 1800. It goes on to examine Bourdieu's ideas of 'objectivated', 'instutionalized' and 'incorporated' cultural capital, in the context of family, inheritance, education and the body. The article identifies changes in the historical forms which cultural capital has taken and emphasizes the importance of analysing family processes of intergenerational transmission.

  7. Differences and Deficits in Psychological Research in Historical Perspective: A Commentary on the Special Section (United States)

    Cole, Michael


    This commentary traces discussions of psychological differences and deficits from the mid-1950s to the current day, positioning the disciplinary discussions in the social-historical context in which they took place. The challenges of assessing diagnoses of deficit and the potential harms that result when misdiagnosis is implemented as social…

  8. Research in the Work of New Zealand Teacher Educators: A Cultural-Historical Activity Theory Perspective (United States)

    Berg, David A. G.; Gunn, Alexandra C.; Hill, Mary F.; Haigh, Mavis


    In this article we use cultural-historical activity theory to explore the place of research in the work of New Zealand university-based teacher educators (TEs). We consider how aspirations for a research-informed initial teacher education are served by New Zealand universities' recruitment practices and TEs' actual work. We suggest that TEs value…

  9. Young People Who Sexually Abuse: A Historical Perspective and Future Directions (United States)

    Rasmussen, Lucinda A.


    This article presents a historical overview of research on sexually abusive youth. The evolution of the field over the past 30 years is discussed--from the initial development of treatment interventions to contemporary efforts of professionals to move from traditional, adult-oriented interventions toward developmentally sensitive assessment…

  10. Historical Empathy as Perspective Recognition and Care in One Secondary Social Studies Classroom (United States)

    Brooks, Sarah


    This qualitative case study examined the place that historical empathy, as both a subjective and an objective endeavor, occupied in one teacher's instruction and her students' response. Data--collected over five months--include 29 hours of classroom observations in an Advanced Placement European History course, instructional artifacts, and…

  11. Skyscape of an Amazonian Diaspora : Arawak Astronomy in Historical Comparative Perspective

    NARCIS (Netherlands)

    Jara Gomez, Fabiola


    The title of this article “Arawak Astronomy” suggests that the research matter concerns the astronomy of an already well-defined ethnographic entity. This however does not do justice to the complexities of Arawak (pre)history. This contribution aims to discuss and connect the available historical an

  12. Understanding and Dismantling Barriers for Partnerships for Inclusive Education: A Cultural Historical Activity Theory Perspective (United States)

    Waitoller, Federico R.; Kozleski, Elizabeth B.


    Increasingly, universities and school districts share responsibility for teacher and student learning. Sharing responsibility demands that both institutions work to develop closer relationships through ongoing engagement, dialogue and negotiation. Drawing from Cultural Historical Activity Theory (CHAT), we examined one school/university…

  13. Historical Perspectives and Recommendations for revision of the Agricultural Handbook 296 (United States)

    While the most recent edition of Agriculture Handbook 296 was released in 2006, many of the geographic boundaries consistently mimic historic map products of generalized regional and national soil-survey maps (some dating back to the 1930s). Furthermore, the underlying concepts and technologies used...

  14. The Ecology of Coeducational Opportunity: The Higher Education of American Women in Historical Perspective. (United States)

    Haines, Patricia Foster

    A case study of Cornell University in its formative years (1868-1900) is presented to suggest the value of the historical approach in understanding the problem of sex-role channeling in the coeducational environment. The case of Cornell illustrates how nineteenth century concepts of femininity and masculinity were fundamental to evolution of both…

  15. Looking through the Looking Glass: A Historical and Factual Perspective on Black Higher "Book Learning." (United States)

    Dease, Barbara C.


    The history of Black colleges and universities is chronicled through excerpts from five articles. Four stages in the colleges' historical development are noted, and the history treats the topics of origins, objectives, legislative landmarks, controversies and conflicts, foreign language education's role, curriculum development, enrollment,…

  16. Perspective has a strong effect on the calculation of historical contributions to global warming (United States)

    Skeie, Ragnhild B.; Fuglestvedt, Jan; Berntsen, Terje; Peters, Glen P.; Andrew, Robbie; Allen, Myles; Kallbekken, Steffen


    The politically contentious issue of calculating countries’ contributions to climate change is strongly dependent on methodological choices. Different principles can be applied for distributing efforts for reducing human-induced global warming. According to the ‘Brazilian Proposal’, industrialized countries would reduce emissions proportional to their historical contributions to warming. This proposal was based on the assumption that the political process would lead to a global top-down agreement. The Paris Agreement changed the role of historical responsibilities. Whereas the agreement refers to equity principles, differentiation of mitigation efforts is delegated to each country, as countries will submit new national contributions every five years without any international negotiation. It is likely that considerations of historical contributions and distributive fairness will continue to play a key role, but increasingly so in a national setting. Contributions to warming can be used as a background for negotiations to inform and justify positions, and may also be useful for countries’ own assessment of what constitutes reasonable and fair contributions to limiting warming. Despite the fact that the decision from COP21 explicitly rules out compensation in the context of loss and damage, it is likely that considerations of historical responsibility will also play a role in future discussions. However, methodological choices have substantial impacts on calculated contributions to warming, including rank-ordering of contributions, and thus support the view that there is no single correct answer to the question of how much each country has contributed. There are fundamental value-related and ethical questions that cannot be answered through a single set of calculated contributions. Thus, analyses of historical contributions should not present just one set of results, but rather present a spectrum of results showing how the calculated contributions vary with a

  17. Science Education and Religion in the Post-Darwin Era: An Historical Perspective (United States)

    Prince, Tiffany


    This article is part of the author's current research into science teachers' perspectives on the theory of evolution and its teaching in the classroom. Anti-evolutionary views have recently become very prominent in the context of science education, with almost one third of science teachers in the United Kingdom agreeing that creationism should be…

  18. A historical perspective of Global Warming Potential from Municipal Solid Waste Management. (United States)

    Habib, Komal; Schmidt, Jannick H; Christensen, Per


    The Municipal Solid Waste Management (MSWM) sector has developed considerably during the past century, paving the way for maximum resource (materials and energy) recovery and minimising environmental impacts such as global warming associated with it. The current study is assessing the historical development of MSWM in the municipality of Aalborg, Denmark throughout the period of 1970 to 2010, and its implications regarding Global Warming Potential (GWP(100)), using the Life Cycle Assessment (LCA) approach. Historical data regarding MSW composition, and different treatment technologies such as incineration, recycling and composting has been used in order to perform the analysis. The LCA results show a continuous improvement in environmental performance of MSWM from 1970 to 2010 mainly due to the changes in treatment options, improved efficiency of various treatment technologies and increasing focus on recycling, resulting in a shift from net emission of 618 kg CO(2)-eq.tonne(-1) to net saving of 670 kg CO(2)-eq.tonne(-1) of MSWM.

  19. Qualitative vs. quantitative atopic dermatitis criteria - in historical and present perspectives

    DEFF Research Database (Denmark)

    Andersen, R M; Thyssen, J P; Maibach, H I


    This review summarizes historical aspects, clinical expression and pathophysiology leading to coining of the terms atopy and atopic dermatitis, current diagnostic criteria and further explore the possibility of developing quantitative diagnostic criteria of atopic dermatitis (AD) based on the imp......This review summarizes historical aspects, clinical expression and pathophysiology leading to coining of the terms atopy and atopic dermatitis, current diagnostic criteria and further explore the possibility of developing quantitative diagnostic criteria of atopic dermatitis (AD) based...... phenomenon. Specific pheno- and endotypes are now emerging potentially enabling us to better classify patients with AD, but the influence of these on the diagnosis of AD is so far unclear. Few diagnostic models use quantitative scoring systems to establish AD cases from normal population, which, however, may...

  20. The development of ICT across the curriculum in Irish schools: a historical perspective


    McGarr, Oliver


    peer-reviewed This literature review explores the historical development of ICT in Irish postprimary/ secondary schools and examines how the education system has responded to the various ICT initiatives and policy changes. The review has found that despite national policy and significant ICT initiatives, it appears that the use of computer technology has instead evolved independent of these changes. The various policy nudges throughout the past three decades have had limited...

  1. Oral submucous fibrosis: a historical perspective and a review on etiology and pathogenesis. (United States)

    Tilakaratne, Wanninayake Mudiyanselage; Ekanayaka, Rasika Priyadharshani; Warnakulasuriya, Saman


    Oral submucous fibrosis (OSF) is a chronic, insidious disease characterized by progressive submucosal fibrosis of the oral cavity and the oropharynx. People affected by this disease mostly live in south Asia, but migrants from these countries to the United States and Europe may present with OSF. We provide a historical background of the disease, and the objective of this review is to update the current knowledge on the etiology and etiopathogenesis of OSF.


    Energy Technology Data Exchange (ETDEWEB)

    Cercy, M.; Peeler, D.; Stone, M.


    This report provides a historical overview and lessons learned associated with the SRS sludge batch (SB) qualification and processing programs. The report covers the framework of the requirements for waste form acceptance, the DWPF Glass Product Control Program (GPCP), waste feed acceptance, examples of how the program complies with the specifications, an overview of the Startup Program, and a summary of continuous improvements and lessons learned. The report includes a bibliography of previous reports and briefings on the topic.

  3. Tourism promotion and urban space in Barcelona : historic perspective and critical review, 1900-1936


    Cocola Gant, Agustin; Palou-Rubio, Saida


    This paper focuses on the historic connections between tourist promotion as a factor for both capital attraction and competitiveness and its influence on the urban configuration of Barcelona. Today, tourism represents a strategic value in the urban organisation of Barcelona and constitutes an excuse for the design, management and planning of the city, but the genealogy of this process has not been considered. In analysing this origin, the paper emphasises the validity of the strategies that w...

  4. [A golden age of the elderly? Old age in a historical perspective]. (United States)

    Luh, Andreas


    The subject of the following article is 'old age' of women and men in prehistoric times, in the ancient Greek and Roman times, in the Middle Ages, in the Age of Enlightenment, in the times of the western industrial civilization and finally in the so-called post-modern civilization (in German terms "Erlebnisgesellschaft") of the present. There is a double focus on the subject. On one hand, the examination deals with the concrete circumstances of living of the elderly people. On the other hand, the examination analyzes the images of old age and the dominant image of the elderly people in the different times. The historical focus shows that old age is no anthropological or biological, unchangeable condition. Old age is a social and cultural construction that is historically formed and can be changed by society. This statement is valid for the number of the elderly in relation to the whole population of a historical society, it is valid for the way of every day life of the elderly and it is also valid to answer the question, who is an 'old' person. 'Old age' and the appearance of 'old age' depends on gender, on sociological items and last but not least on individual conditions during the different historical times. Dominant and strongly changing images of old age can be seen in all periods of human culture, in ancient times, in the Middle Ages and also in modern times. These images (negative or positive) depend strongly on the economic circumstances and conditions of living. Connected with these analyzed images of old age in all former cultures are concrete systems of values that have a leading function for the whole society.

  5. China’s Land-Use Changes during the Past 300 Years: A Historical Perspective (United States)

    Miao, Lijuan; Zhu, Feng; Sun, Zhanli; Moore, John C.; Cui, Xuefeng


    Understanding the processes of historical land-use change is crucial to the research of global environmental sustainability. Here we examine and attempt to disentangle the evolutionary interactions between land-use change and its underlying causes through a historical lens. We compiled and synthesized historical land-use change and various biophysical, political, socioeconomic, and technical datasets, from the Qing dynasty to modern China. The analysis reveals a clear transition period between the 1950s and the 1980s. Before the 1950s, cropland expanded while forested land diminished, which was also accompanied by increasing population; after the 1980s land-use change exhibited new characteristics: changes in cropland, and decoupling of forest from population as a result of agricultural intensification and globalization. Chinese political policies also played an important and complex role, especially during the 1950s–1980s transition periods. Overall, climate change plays an indirect but fundamental role in the dynamics of land use via a series of various cascading effects such as shrinking agricultural production proceeding to population collapse and outbreaks of war. The expected continuation of agricultural intensification this century should be able to support increasing domestic demand for richer diets, but may not be compatible with long-term environmental sustainability. PMID:27571087

  6. Godzilla in the corridor: The Ontario SARS crisis in historical perspective. (United States)

    Rankin, John


    Ontario nurses were employed as the front-line workers when SARS descended upon Toronto in March 2003. Once the crisis had subsided, many nurses remarked that SARS had forever altered their chosen profession; employment, which they once viewed as relatively safe, had been transformed into potentially life-threatening. This discussion provides descriptions of these expressions through nurses who experienced the crisis and chose to go on the public record. Secondly, it compares the subjective perceptions of those nurses to those held by nurses who worked through historical epidemics of unknown or contested epidemiology. The historical literature on nursing in yellow fever, cholera and influenza epidemics has been employed to offer insight. The goal is to determine whether the SARS outbreak was a unique experience for nurses or whether similar experiences were shared by nurses in the past? In summary, the reactions of nurses when confronted with the possibility of contracting a deadly disease remain altogether human, not dissimilar in past or present. Nurses' responses to SARS can be usefully studied within a larger historical vision of crisis nursing, and information or impressions from earlier crises are potentially of interest to the nursing profession.

  7. China’s Land-Use Changes during the Past 300 Years: A Historical Perspective

    Directory of Open Access Journals (Sweden)

    Lijuan Miao


    Full Text Available Understanding the processes of historical land-use change is crucial to the research of global environmental sustainability. Here we examine and attempt to disentangle the evolutionary interactions between land-use change and its underlying causes through a historical lens. We compiled and synthesized historical land-use change and various biophysical, political, socioeconomic, and technical datasets, from the Qing dynasty to modern China. The analysis reveals a clear transition period between the 1950s and the 1980s. Before the 1950s, cropland expanded while forested land diminished, which was also accompanied by increasing population; after the 1980s land-use change exhibited new characteristics: changes in cropland, and decoupling of forest from population as a result of agricultural intensification and globalization. Chinese political policies also played an important and complex role, especially during the 1950s–1980s transition periods. Overall, climate change plays an indirect but fundamental role in the dynamics of land use via a series of various cascading effects such as shrinking agricultural production proceeding to population collapse and outbreaks of war. The expected continuation of agricultural intensification this century should be able to support increasing domestic demand for richer diets, but may not be compatible with long-term environmental sustainability.

  8. The meaning of 'community' in the lives of people with intellectual disabilities: an historical perspective. (United States)

    Jarrett, Simon


    This paper critically examines the term 'community' as applied to people with intellectual disabilities over time and aims to describe its shifting conceptualisation from the eighteenth century to the present day. Unpublished documentary sources from Old Bailey criminal trials in the eighteenth century, the Earlswood Idiot asylum in the mid-nineteenth-century and early-twentieth-century government reports have been used to explore historical changes in the concept of community. The word community is historically contingent both in its past and present uses. Its meaning has been adapted to strengthen and justify professional claims to own, treat and manage people with intellectual disabilities. Inclusion and community acceptance were normative in the eighteenth century. In later medicalized institutionalization programmes the meaning of community was subverted to endorse and vindicate professional claims. It has been further adapted since deinstitutionalization to support contemporary claims for the social model of community inclusion. Today's language of inclusion emanates from these historical conceptual shifts, masking a set of unconscious assumptions and meanings attached to the status of intellectually disabled people. The modern concept of community is based on an assumption that people with intellectual disabilities have always been excluded. In the collective memory, it has been forgotten that they were, before the asylum, natural members of community embedded within social, economic, and familial networks. It is communities themselves that must adapt and remodel rather than trying to remodel those people they originally excluded.

  9. Hormesis depends upon the life-stage and duration of exposure: examples for a pesticide and a nanomaterial


    Tyne, William; Little, Simon; Spurgeon, David J.; Svendsen, Claus


    Tests to assess toxic effects on the reproduction of adult C. elegans after 72 h exposure for two chemicals, (3-(3,4-dichlorophenyl)-1,1-dimethylurea (DCMU)), also known as diuron, and silver nanoparticles (Ag NPs) indicated potential, although not significant hormesis. Follow up toxicity tests comparing the potential hormesis concentrations with controls at high replication confirmed that the stimulatory effect was repeatable and also statistically significant within the test. To...

  10. Gender issues and Japanese family-centered caregiving for frail elderly parents or parents-in-law in modern Japan: From the sociocultural and historical perspectives



    This paper presents a sociocultural and historical literature review of gender related issues associated with family-centered caregiving for frail, elderly relatives in modern Japan. Issues addressed from a Japanese perspective are (a) women and social norms of caregiving, (b) feminine identity and caregiving, (c) women in the workforce, and (d) women and caregiving. Implications for research are also discussed.

  11. Gender issues and Japanese family-centered caregiving for frail elderly parents or parents-in-law in modern Japan: from the sociocultural and historical perspectives. (United States)

    Hashizume, Y


    This paper presents a sociocultural and historical literature review of gender related issues associated with family-centered caregiving for frail, elderly relatives in modern Japan. Issues addressed from a Japanese perspective are (a) women and social norms of caregiving, (b) feminine identity and caregiving, (c) women in the workforce, and (d) women and caregiving. Implications for research are also discussed.

  12. Perezhivanie and classroom discourse: a cultural-historical perspective on "Discourse of design based science classroom activities" (United States)

    Adams, Megan; March, Sue


    Flavio Azevedo, Peggy Martalock and Tugba Keser challenge the `argumentation focus of science lessons' and propose that through a `design-based approach' emergent conversations with the teacher offer possibilities for different types of discussions to enhance pedagogical discourse in science classrooms. This important paper offers a "preliminary contribution to a general theory" regarding the link between activity types and discourse practices. Azevedo, Martalock and Keser offer a general perspective with a sociocultural framing for analysis of classroom discourse. Interestingly the specific concepts drawn upon are from conversation analysis; there are few sociocultural concepts explored in detail. Therefore, in this article we focus on a cultural historical (Vygotsky in The collected works of L. S. Vygotsky. The history and development of higher mental functions, vol 4. Plenum Press, New York, 1987; The Vygotsky reader. Black, Cambridge, 1994) methodology to explore, analyse and explain how we would use a different theoretical lens. We argue that a cultural historical reading of argumentation in science lessons and design based activity will expand Azevedo, Martalock and Keser's proposed general theory of activity types and discourse practices. Specifically, we use Lev Vygotksy's idea of perezhivanie as the unit of analysis to reconceptualise this important paper. We focus on the holistic category of students' emotional experience through discourse while developing scientific awareness.

  13. Solar System Exploration Augmented by Lunar and Outer Planet Resource Utilization: Historical Perspectives and Future Possibilities (United States)

    Palaszewski, Bryan


    Establishing a lunar presence and creating an industrial capability on the Moon may lead to important new discoveries for all of human kind. Historical studies of lunar exploration, in-situ resource utilization (ISRU) and industrialization all point to the vast resources on the Moon and its links to future human and robotic exploration. In the historical work, a broad range of technological innovations are described and analyzed. These studies depict program planning for future human missions throughout the solar system, lunar launched nuclear rockets, and future human settlements on the Moon, respectively. Updated analyses based on the visions presented are presented. While advanced propulsion systems were proposed in these historical studies, further investigation of nuclear options using high power nuclear thermal propulsion, nuclear surface power, as well as advanced chemical propulsion can significantly enhance these scenarios. Robotic and human outer planet exploration options are described in many detailed and extensive studies. Nuclear propulsion options for fast trips to the outer planets are discussed. To refuel such vehicles, atmospheric mining in the outer solar system has also been investigated as a means of fuel production for high energy propulsion and power. Fusion fuels such as helium 3 (3He) and hydrogen (H2) can be wrested from the atmospheres of Uranus and Neptune and either returned to Earth or used in-situ for energy production. Helium 3 and H2 (deuterium, etc.) were the primary gases of interest with hydrogen being the primary propellant for nuclear thermal solid core and gas core rocket-based atmospheric flight. A series of analyses have investigated resource capturing aspects of atmospheric mining in the outer solar system. These analyses included the gas capturing rate, storage options, and different methods of direct use of the captured gases. While capturing 3He, large amounts of hydrogen and 4He are produced. With these two additional

  14. Fish and fisheries in the Lower Rhine 1550-1950: A historical-ecological perspective. (United States)

    Lenders, H J Rob


    Regulation and intensive use of most of the world's large rivers, has led to dramatic decline and even to extinction of riverine fish populations like salmon and sturgeon in the river Rhine. In general this decline is considered an unwelcome side-effect of the Industrial Revolution and large-scale river regulation (c. 1800), but the deterioration of stocks of some species may have started well before the 19th century. For the river Rhine, data on fish landings as proxies of abundance in the period 1550-1950 can be derived from historical market prices, fisheries taxation and fishery and fish auctions statistics, especially for commercially interesting species like Atlantic salmon, sturgeon, Allis shad and Twaite shad. Most data from which abundance of these species can be derived, however, appear to be missing in historical sources until decline of the investigated species sets in and the species become economically scarce goods. Atlantic salmon in the Rhine catchment appears to be already in decline during Early Modern Times (post 1500 AD) after which time river regulation, pollution and intensified fisheries finished off the remaining stocks in the 20th century. Salmon decline caused a cascade in the River Rhine ecosystem as fisheries shifted to, especially, Allis shad and Twaite shad, followed by (near-)extinction of these species. Dropping yields of salmon fishery did not lead to increased sturgeon fishery, although numbers of sturgeon also dwindled to extinction in the river Rhine. The onset of sturgeon decline appears to coincide with the period of the first large regulation works. It is shown that historical-ecological data on fish abundance can quantitatively underpin detrimental long-term processes in river ecosystems.

  15. Robert H. Pudenz (1911-1998) and Ventriculoatrial Shunt: Historical Perspective. (United States)

    Konar, Subhas K; Maiti, Tanmoy K; Bir, Shyamal C; Kalakoti, Piyush; Nanda, Anil


    Robert H. Pudenz was a renowned neurosurgeon in North America in the 20th century, famous for his contributions in the evolution of the shunt valve and ventriculoatrial shunt surgery. With his innovative idea and help from Heyer, in 1955, he demonstrated that a venous catheter worked best when in the right atrium and that the slit valve should be located at the most distal portion of the shunt system to prevent retrograde filling and thrombosis. He also contributed to various experimental studies on the brain, especially the electrical response of different neural structures. This historical vignette focuses on the work of Robert Pudenz and the evolution of the ventriculoatrial shunt.

  16. Women in physics in El Salvador: Historical perspectives and current challenges (United States)

    Jiménez, Telma; Jiménez, Diana; Larios, Gloria


    Physics as a discipline in El Salvador's higher education system has struggled historically; however, since 1991, it has enjoyed a growth-friendly environment. While there are few female physicists in El Salvador, they are employed in various organizations and educational institutions, demonstrating that physics is a viable career path. El Salvador currently offers a range of opportunities for women in physics. With the support of the 5th IUPAP International Conference on Women in Physics, we will both meet the challenges and take advantage of the opportunities that face female physicists in El Salvador.

  17. A conceptual perspective for investigating motive in cultural-historical theory

    DEFF Research Database (Denmark)

    Chaiklin, Seth


    This chapter provides a brief discussion of the other chapters in this edited volume, and then presents a brief introduction to the concept of motive within cultural-historical theory. This discussion includes a discussion of why the concept is needed, the ontological shift in the explanatory logic...... of the theory, the relation of the concept in the theory of activity. The main section of the chapter provides a methodological discussion of ways to research the motive concept. The chapter concludes with three open research problems in relation to the motive concept....

  18. Multiaxial and Thermomechanical Fatigue of Materials: A Historical Perspective and Some Future Challenges (United States)

    Kalluri, Sreeramesh


    Structural materials used in engineering applications routinely subjected to repetitive mechanical loads in multiple directions under non-isothermal conditions. Over past few decades, several multiaxial fatigue life estimation models (stress- and strain-based) developed for isothermal conditions. Historically, numerous fatigue life prediction models also developed for thermomechanical fatigue (TMF) life prediction, predominantly for uniaxial mechanical loading conditions. Realistic structural components encounter multiaxial loads and non-isothermal loading conditions, which increase potential for interaction of damage modes. A need exists for mechanical testing and development verification of life prediction models under such conditions.

  19. India–EU engagement and international migration: Historical perspectives, future challenges, and policy imperatives

    Directory of Open Access Journals (Sweden)

    Basant Kumar Potnuru


    Full Text Available In the absence of a multilateral framework and a rule based global structure for the governance of international migration of people in all its complexities, countries engage in bilateral or regional cooperation in an attempt to engage and harmonize international movements and work towards a win–win situation. The current paper examines if and how the bilateral relationship or engagement between India and the EU has historically evolved and influenced international migration flows between them, and what potential future challenges and policy options they face for a successful engagement and facilitation of movement of people.

  20. Italian Chemists’ Contributions to Named Reactions in Organic Synthesis: An Historical Perspective

    Directory of Open Access Journals (Sweden)

    Gianluca Papeo


    Full Text Available From the second half of the 19th century up to modern times, the tremendous contribution of Italian chemists to the development of science resulted in the discovery of a number of innovative chemical transformations. These reactions were subsequently christened according to their inventors’ name and so entered into the organic chemistry portfolio of “named organic reactions”. As these discoveries were being conceived, massive social, political and geographical changes in these chemists’ homeland were also occurring. In this review, a brief survey of known (and some lesser known named organic reactions discovered by Italian chemists, along with their historical contextualization, is presented.

  1. Industrial Property and global competitiveness in historical perspective; Propiedad industrial y competitividad global en perspectiva historica

    Energy Technology Data Exchange (ETDEWEB)

    Saiz, P.


    The ability to compete globally changes over time. The processes of technological innovation and education largely determine economic growth and international competitiveness. The development and evolution of Intellectual Property Rights in the long term have been essential for the management of R and D and of creative and innovative competence's in several countries. Thus, economic and technological history becomes an essential tool for analysts and political economists. And the historical archive of the Spanish Patents and Trademarks Office turns out to be a laboratory of the past for thinking on the future. (Author) 48 refs.

  2. The hunt for the dynamical resonances in chemical reaction dynamics: a perspective on historical advances

    Directory of Open Access Journals (Sweden)

    Yu Angyang


    Full Text Available The theoretical background and basic definition of the resonances in chemical reaction dynamics have been introduced in this article. The historical breakthrough in the experimental search for the reaction resonances has been reviewed in this report, with an emphasis on the crossed molecular beam apparatus. The research of the chemical reaction resonances has attracted many scientists’ attention from 80s of last century. The chemical reaction resonances in the F+H2 reaction were firstly observed by the researchers of the Chinese Academy of Sciences in 2006. Besides, the partial wave resonances in the chemical reactions have been observed for the first time in 2010.

  3. Europe of Monnet, Schumann and Mitrany: A Historical Glance to the EU from the Functionalist Perspective

    Directory of Open Access Journals (Sweden)

    Umit Kurt


    Full Text Available The introductory article to this special issue pursues two main objectives, one empirical the other theoretical. This paper investigates the European Coal and Steel Community, established in 1951, as an empirical reality. After explaining the historical background of the European Coal and Steel Community (ECSC, the paper tries to explain the ECSC through functionalist approach or theory, which is very debatable among scholars. The paper then concludes that at the very beginning the best way to understand the process of European integration within the framework of theoretical conceptualization is to take functionalism as an approach or perhaps a mid-range theory what Simon Hix (2004 used.

  4. Europe of Monnet, Schumann and Mitrany: A Historical Glance to the EU from the Functionalist Perspective

    Directory of Open Access Journals (Sweden)

    Ümit Kurt


    Full Text Available The introductory article to this special issue pursues two main objectives, one empirical the other theoretical. This paper investigates the European Coal and Steel Community, established in 1951, as an empirical reality. After explaining the historical background of the European Coal and Steel Community (ECSC, the paper tries to explain the ECSC through functionalist approach or theory, which is very debatable among scholars. The paper then concludes that at the very beginning the best way to understand the process of European integration within the framework of theoretical conceptualization is to take functionalism as an approach or perhaps a mid-range theory what Simon Hix (2004 used.

  5. Myth of the ideal cesarean section rate: commentary and historic perspective. (United States)

    Cyr, Ronald M


    Attempts to define, or enforce, an "ideal" cesarean section rate are futile, and should be abandoned. The cesarean rate is a consequence of individual value-laden clinical decisions, and is not amenable to the methods of evidence-based medicine. The influence of academic authority figures on the cesarean rate in the US is placed in historic context. Like other population health indices, the cesarean section rate is an indirect result of American public policy during the last century. Without major changes in the way health and maternity care are delivered in the US, the rate will continue to increase without improving population outcomes.

  6. The Regulation of Market Manipulation in Australia: A Historical Comparative Perspective

    Directory of Open Access Journals (Sweden)

    Howard Chitimira


    Full Text Available Notably, in Australia, market abuse practices like market manipulation and other market misconduct practices are expressly prohibited under the Corporations Act as amended by the Financial Services Reform Act. In the light of this, and for the purposes of this article, a brief historical analysis of the market manipulation prohibition will be presented first. Secondly, the available penalties and remedies for market manipulation are discussed. Thereafter, possible recommendations and significant Australian anti-market abuse enforcement approaches that may be utilised in South Africa are briefly stated. Lastly, concluding remarks are provided.

  7. A Historical Perspective in the Christian-Muslim Relations in Nigeria since 1914

    Directory of Open Access Journals (Sweden)

    Adamolekun Taiye


    Full Text Available This paper discusses Christian- Muslim relations in Nigeria since 1914. In achieving the objective in this paper, Historical approach is adopted. It gives a historical survey of the evolution of Nigeria and the attitude of colonial administration to religious propaganda. The method of conversion adopted by Islam and Christianity in pre-independence is discussed .The independence and republican constitution provision for religious freedom is pointed out. The role of military Government on religious development and interaction is identified. 1978 Nigeria constituent Assembly debate on Sharia court of appeal and 1979 constitution on Religious affairs are discussed. New dimension in Religious propaganda, fanaticism, fundamentalism, and Religious Politics since 1980 is discussed. The 1999 constitution and Sharia law in the civilian dispensation is identified. Religious terrorism as practised by maitasine and Boko Haram sects is discussed. It is discovered that various factors contributed and affected Christian-Muslim relationship in Nigeria. The paper concludes with suggestions and solutions to the problems affecting Christian-Muslim relations.

  8. The nude in medical photography: a historical perspective, with modern legal ramifications. (United States)

    Burns, S B


    Taking medical photographs of nude patients was common in the nineteenth century and was related to the diagnostic promises of photography. Nude photography today, while just as diagnostically important, is a carefully thought out practice fraught with serious legal ramifications especially when dealing with children and adolescents. As members of the human race, we are diverse in our practices and not only on a country wide but a regional level. What is acceptable in New York is not necessarily acceptable in central Kansas. Unfortunately, in many circumstances, it is difficult to measure intent. Vintage medical photographs have become valued as art, as well as historic and cultural documents. Nude vintage medical photographs fully expose the human condition and have become among the most valued of historic medical photographs. The implications for the future treatment of nude medical photography is well established. The passage of time, nostalgia, and, most importantly, the attempt to learn the secrets of life and means of death in past epochs will result in preserving and valuing these most important clinical photographs.

  9. A historical perspective on the economics of the ownership of mineral rights ownership

    Energy Technology Data Exchange (ETDEWEB)

    Cawood, F.T.; Minnitt, R.C.A. [Technikon SA, Florida (South Africa). Dept. of Engineering


    Inauguration of the new political dispensation in South Africa, initiated a dynamic period in the historical development of its minerals policy. The process of substituting the current South African mineral policy framework with an acceptable `post apartheid` system, started soon after the 1994 election of the African National Congress (ANC) government. The Green Paper on a Minerals and Mining Policy for South Africa released for public discussion in February 1998, calls for radical transformation in mineral rights ownership. A shift towards exclusive state ownership of mineral rights, away from the present dual system of private and state ownership, is the most significant proposal. The current holders of mineral rights, or their nominees, who lawfully enjoyed security of tenure under past and present mineral laws are opposed to this transformation because mineral rights were often acquired at considerable cost. The situation is compounded by poor public record-keeping and passive mineral rights administration over a very long period. This paper represents a summary of the historical developments leading to the current legislative environment and forms the basis for any discussion on which future sculpturing of South Africa`s policy regarding mineral rights can take place. One cannot plan for the future without considering the past. 21 refs.

  10. Comparing World Economic and Net Energy Metrics, Part 3: Macroeconomic Historical and Future Perspectives

    Directory of Open Access Journals (Sweden)

    Carey W. King


    Full Text Available I use energy cost share to characterize the role of energy in the economy. Specifically, I use an estimate of monetary expenditures for primary energy on an annualized basis for forty-four countries from 1978 to 2010 for natural gas, coal, petroleum, and electricity. I show that global energy cost share is significantly correlated to a one-year lag in the change in gross domestic product as well as measures of total factor productivity. Given the historical reduction in the relative cost of energy (including food and fodder for animate power since the start of the Industrial Revolution, combined with a global energy cost share estimate, I conclude that the turn of the 21st Century represents the time period with the cheapest energy in the history of human civilization (to date. This potential historical nadir for energy expenditures around 2000 has important ramifications for strategies to solve future social, economic, and environmental problems such as reducing annual emissions of greenhouse gases (GHGs. Rapidly decreasing annual GHG emissions while internalizing their costs into the economy might feedback to increase energy expenditures to such a degree as to prevent economic growth during that transition.

  11. Growth and yield models in Spain: Historical overview, Contemporary Examples and perspectives

    Energy Technology Data Exchange (ETDEWEB)

    Bravo, F.; Alvarez-Gonzalez, J. G.; Rio, M. del; Barrio, M.; Bonet, J. a.; Bravo-Oviedo, A.; Calama, R.; Castedo-Dorado, F.; Crecente-Campo, F.; Condes, S.; Dieguez-Aranda, U.; Gonzalez-Martinez, S. C.; Lizarralde, I.; Nanos, N.; Madrigal, A.; Martinez-Millan, F. J.; Montero, G.; Ordonez, C.; Palahi, M.; Pique, M.; Rodriguez, F.; Rodriguez-Soalleiro, R.; Rojo, A.; Ruiz-Peinado, R.; Sanchez-Gonzalez, M.; Trasobares, A.; Vazquez-Pique, J.


    In this paper we present a review of forest models developed in Spain in recent years for both timber and non timber production and forest dynamics (regeneration, mortality,..). Models developed are whole stand, size (diameter) class and individual-tree. The models developed to date have been developed using data from permanent plots, experimental sites and the National Forest Inventory. In this paper we show the different sub-models developed so far and the friendly use software. Main perspectives of forest modelling in Spain are presented. (Author) 107 refs.

  12. Economists, capitalists, and the making of globalization: North American free trade in comparative-historical perspective. (United States)

    Fairbrother, Malcolm


    Why did globalization happen? Current explanations point to a variety of conditions under which states have made the free market policy changes driving international economic integration since the 1980s. Such accounts disagree, however, about the key actors involved. This article provides a reconciliation, showing how two different combinations of actors, and two different political economic pathways, have led to globalization in recent decades. In developed countries, mobilization by business has been central; elsewhere, technocrats both constrained and empowered by international finance have pursued globalization more independently of business. In both contexts, economists' technical authority has helped legitimate liberalization, despite the limited diffusion of their ideas. The article validates and elaborates this model using a comparative-historical study of how the United States, Canada, and Mexico proposed, negotiated, and ratified agreements for free trade in North America.

  13. [The Gioconda from the historical and medical perspective (hypotheses of pathology in her painting)]. (United States)

    Cruz Hermida, J


    As a preamble, some historical and biographical brushtrokes of the Gioconda, Leonardo and his painting will be outlined. Following these observations, a series of medical interpretations will be put forth regarding his painting with the aim of analysing possible pathologies related to: the skin, hair, eyes, hands and the reproductive and endocrine systems. We will conclude by observing the famous work The Smile and by extracting a hypothesis on pathologies of various natures such as: neurological, muscular, hypoacusic, asthmatic, psychoneurotic, psychiatric, ethylic, sexual, stress-related, stomatological (bruxismo) and the driving force that lies behind setting off the Stendhal Syndrome: a psychosomatic disorder known to be due to the human being's susceptibility to saturation from having received impressions of great artistic beauty.

  14. Quantitative analysis of saltwater-freshwater relationships in groundwater systems-A historical perspective (United States)

    Reilly, T.E.; Goodman, A.S.


    Although much progress has been made toward the mathematical description of saltwater-freshwater relationships in groundwater systems since the late 19th century, the advective and dispersive mechanisms involved are still incompletely understood. This article documents the major historical advances in this subject and summarizes the major direction of current studies. From the time of Badon Ghyben and Herzberg, it has been recognized that density is important in mathematically describing saltwater-freshwater systems. Other mechanisms, such as hydrodynamic dispersion, were identified later and are still not fully understood. Quantitative analysis of a saltwater-freshwater system attempts to mathematically describe the physical system and the important mechanisms using reasonable simplifications and assumptions. This paper, in developing the history of quantitative analysis discusses many of these simplifications and assumptions and their effect on describing and understanding the phenomenon. ?? 1985.

  15. Native American men-women, lesbians, two-spirits: Contemporary and historical perspectives. (United States)

    Lang, Sabine


    People living in the role of the "other" sex in Native American cultures, often entering into same-sex relationships, have been subject to various anthropological, historical, and psychological analyses and interpretations. Most recently, there has been a shift to an indigenist/decolonial interdisciplinary focus on lesbian, gay, bisexual, transgender, and queer Native people. This article gives a discussion of approaches to the subject, with a focus on female gender variability. An overview is given of the latter, complemented by a discussion of the identities and concerns of contemporary Native lesbians, many of whom identify as "two-spirit," a term that alludes to the dual, spiritually powerful nature traditionally attributed in a number of Native American cultures to individuals who combine the feminine and masculine.

  16. The Hydraulic Option in Former Soviet Central Asia. Historical Perspective and Current Situation

    Directory of Open Access Journals (Sweden)

    Laura Vea Rodríguez


    Full Text Available This paper deals with the situation of water resource management in the five Central Asian republics that formed part of the USSR. By way of introduction, it lists the characteristics of water as a resource and then analyses the uses and distribution of water in the region.For this, it outlines a brief historical approach which helps to understand, in all its magnitude, the current situation of ecological degradation and how it determines living conditions in the region. Likewise, it deals with the policies of intervention in water resource management of the Central Asian states and of international institutions, and it includes the description of two specific case studies which form part of initiatives devoted to reversing a processwhich has led to the greatest ecological disaster on the planet, the most well-known aspect of which is the practical disappearance of the Aral Sea.

  17. Discourse about Synthetic Biology and Responsible Innovation: Notes from a Historical Perspective

    Directory of Open Access Journals (Sweden)

    Christopher Coenen


    Full Text Available Dominated as it is by visionary images of the future and influenced by the ‘Responsible Research and Innovation’ (RRI approach, the discourse about synthetic biology (SynBio and the prospects for its application may be interpreted as an arena for argument about the future of our societies generally. At a time when the widespread end of the systemic conflict between capitalism and socialism has made it rare for the whole of society to engage in debates on fundamental political and socioeconomic issues, discourses on science and technology can apparently be used to address questions of this kind indirectly. It is possible to clarify this function of SynBio discourse by setting it in its historical context, in which respect the focus is placed on older discourses about the societal significance of biology and its technological applications.

  18. Paradigms and public policies on drought in northeast Brazil: a historical perspective. (United States)

    Campos, José Nilson B


    This paper describes the evolution of drought-related public policies in Northeast Brazil (NEB). Using a historical approach, we show that the evolution of public policy has not been characterized by abrupt shifts, but has instead been shaped through debates between renowned intellectuals. The resulting public policies formed a hydrological infrastructure that delivers clean water needed for robust economic activity. However, outcomes of the 2012-2013 drought show that populations that depend on rain fed agriculture are as vulnerable to drought as they were at the start of the 20th century. Although government, social, and emergency programs have aided drought victims, drought analysts agree that rain fed agriculture has remained vulnerable since drought policies were first formulated. Drought policies formulate integrated water resources management (IWRM) strategies that are geared toward supplying safe drinking water, and debates surrounding the IWRM paradigm have been affected by outcomes of major international events such as the World Water Forum.

  19. Religious morality (and secular humanism) in Western civilization as precursors to medical ethics: A historic perspective (United States)

    Faria, Miguel A.


    In discussing bioethics and the formulation of neuroethics, the question has arisen as to whether secular humanism should be the sole philosophical guiding light, to the exclusion of any discussion (or even mention) of religious morality, in professional medical ethics. In addition, the question has arisen as to whether freedom or censorship should be part of medical (and neuroscience) journalism. Should independent medical journals abstain from discussing certain issues, or should only the major medical journals — i.e., the New England Journal of Medicine (NEJM), the Journal of the American Medical Association (JAMA) or Lancet — be heard, speaking with one “consensual,” authoritative voice? This issue is particularly important in controversial topics impacting medical politics — e.g., public health policy, socio-economics, bioethics, and the so-called redistributive justice in health care. Should all sides be heard when those controversial topics are discussed or only a consensual (monolithic) side? This historical review article discusses those issues and opts for freedom in medical and surgical practice as well as freedom in medical journalism, particularly in opinion pieces such as editorials, commentaries, or letters to the editor, as long as they relate to medicine and, in our special case, to neuroscience and neurosurgery. After answering those questions, and in response to a critical letter to the editor, this review article then expounds comprehensively on the historical and philosophical origins of ethics and religious morality. Necessarily, we discuss the Graeco-Roman legacy and the Judeo-Christian inheritance in the development of ethics and religious morality in Western civilization and their impact on moral conduct in general and on medical and neuroscience ethics in particular. PMID:26110085

  20. Religious morality (and secular humanism in Western civilization as precursors to medical ethics: A historic perspective

    Directory of Open Access Journals (Sweden)

    Miguel A Faria


    Full Text Available In discussing bioethics and the formulation of neuroethics, the question has arisen as to whether secular humanism should be the sole philosophical guiding light, to the exclusion of any discussion (or even mention of religious morality, in professional medical ethics. In addition, the question has arisen as to whether freedom or censorship should be part of medical (and neuroscience journalism. Should independent medical journals abstain from discussing certain issues, or should only the major medical journals - i.e., the New England Journal of Medicine (NEJM, the Journal of the American Medical Association (JAMA or Lancet - be heard, speaking with one "consensual," authoritative voice? This issue is particularly important in controversial topics impacting medical politics - e.g., public health policy, socio-economics, bioethics, and the so-called redistributive justice in health care. Should all sides be heard when those controversial topics are discussed or only a consensual (monolithic side? This historical review article discusses those issues and opts for freedom in medical and surgical practice as well as freedom in medical journalism, particularly in opinion pieces such as editorials, commentaries, or letters to the editor, as long as they relate to medicine and, in our special case, to neuroscience and neurosurgery. After answering those questions, and in response to a critical letter to the editor, this review article then expounds comprehensively on the historical and philosophical origins of ethics and religious morality. Necessarily, we discuss the Graeco-Roman legacy and the Judeo-Christian inheritance in the development of ethics and religious morality in Western civilization and their impact on moral conduct in general and on medical and neuroscience ethics in particular.

  1. Can poisons stimulate bees? Appreciating the potential of hormesis in bee-pesticide research. (United States)

    Cutler, G Christopher; Rix, Rachel R


    Hormesis, a biphasic dose response whereby exposure to low doses of a stressor can stimulate biological processes, has been reported in many organisms, including pest insects when they are exposed to low doses of a pesticide. However, awareness of the hormesis phenomenon seems to be limited among bee researchers, in spite of the increased emphasis of late on pollinator toxicology and risk assessment. In this commentary, we show that there are several examples in the literature of substances that are toxic to bees at high doses but stimulatory at low doses. Appreciation of the hormetic dose response by bee researchers will improve our fundamental understanding of how bees respond to low doses of chemical stressors, and may be useful in pollinator risk assessment.

  2. Sex specific effects of heat induced hormesis in Hsf-deficient Drosophila melanogaster

    DEFF Research Database (Denmark)

    Sørensen, J G; Kristensen, Torsten Nygård; Kristensen, K V;


    In insects mild heat stress early in life has been reported to increase life span and heat resistance later in life, a phenomenon termed hormesis. Here, we test if the induction of the heat shock response by mild heat stress is mediating hormesis in longevity and heat resistance at older age....... To test this hypothesis we used two heat shock transcription factor (Hsf) mutant stocks. One stock harbours a mutation giving rise to a heat sensitive Hsf which inactivates the heat shock response at high temperature and the other is a rescued mutant giving rise to a wild-type phenotype. We measured...... longevity, heat resistance and expression level of a heat shock protein, Hsp70, in controls and mildly heat treated flies. We found a marked difference between males and females with males showing a beneficial effect of the early heat treatment on longevity and heat resistance later in life in the rescued...

  3. Hormesis, allostatic buffering capacity and physiological mechanism of physical activity: a new theoretic framework. (United States)

    Li, Guolin; He, Hong


    Despite great progress made in sports medicine, the physiological mechanism of moderate physical activity-induced physical fitness remains only partly understood. Combined with the hormetic characteristic of physical activity and property of allostasis, we first propose the hormesis induced allostatic buffering capacity enhancement as a physiological mechanism to explain the moderate physical activity-induced physical fitness. As stressful stimulus, physical activity can induce several stresses in the host, including eustress ('good stress') and distress ('bad stress'), which may have both positive and negative effects. Too little or too much physical activities will introduce too weak eustress or too strong distress and result in allostasis load through weakening allostatic buffering capacity or damaging allostatic buffering capacity respectively. However, moderate physical activities will introduce eustress and contribute to the hormesis induced allostatic buffering capacity enhancement, which benefits organism.

  4. Targeting the age-related occurrence, removal, and accumulation of molecular damage by hormesis. (United States)

    Rattan, Suresh I S


    Strategies for testing and developing effective means of intervention, prevention, and modulation of aging incorporate means to minimize the occurrence and accumulation of molecular damage, to reduce molecular heterogeneity, and to evaluate the relevance of the type and extent of damage with respect to its role in aging and age-related diseases. One such approach is that of mild stress-induced hormesis, which stimulates maintenance and repair systems and strengthens the homeodynamic space of cells and organisms. Hormesis through mild heat shock, natural and synthetic hormetins, and other stressors brings about several antiaging effects in human fibroblasts, keratinocytes, and telomerase-immortalized bone marrow stem cells. Depending on the cell type, these antiaging hormetic effects include extension of replicative life span, enhanced proteasomal activities, increased chaperone levels, and improved wound healing, angiogenesis, and differentiation. The main molecular pathways for achieving such hormetic effects are through targeting the processes for the repair and removal of molecular damage, which can slow aging.

  5. My Historical Perspective on the ONR Coastal Science Program and the Kinder Years (United States)

    Thornton, E. B.


    My perspective on the ONR Coastal Science program and the role of Tom Kinder is presented. The history of the program and how it evolved is presented, starting with my participation in the early 70's to the present. Comprehensive near shore field experiments from NSTS and "the Ducks", to RIPEX and the future NCEX and their importance to improving our knowledge base is discussed. The evolution of instrumentation techniques used in nearshore field experiments are reviewed. The importance of the efficiencies of digital technology and improvements in instrumentation with increased temporal and spatial resolution to field measurements are presented. A view toward the future with emphasis on how Tom has helped lead us is discussed.

  6. Hormesis-Based Anti-Aging Products: A Case Study of a Novel Cosmetic


    Rattan, Suresh I.S.; Kryzch, Valérie; Schnebert, Sylvianne; Perrier, Eric; Nizard, Carine


    Application of hormesis in aging research and interventions is becoming increasingly attractive and successful. The reason for this is the realization that mild stress-induced activation of one or more stress response (SR) pathways, and its consequent stimulation of repair mechanisms, is effective in reducing the age-related accumulation of molecular damage. For example, repeated heat stress-induced synthesis of heat shock proteins has been shown to have a variety of anti-aging effects on gro...

  7. Nutrient removal by Chlorella vulgaris F1068 under cetyltrimethyl ammonium bromide induced hormesis. (United States)

    Zhou, Qiongzhi; Li, Feng; Ge, Fei; Liu, Na; Kuang, Yangduo


    Toxicants are generally harmful to biotechnology in wastewater treatment. However, trace toxicant can induce microbial hormesis, but to date, it is still unknown how this phenomenon affects nutrient removal during municipal wastewater treatment process. Therefore, this study focused on the effects of hormesis induced by cetyltrimethyl ammonium bromide (CTAB), a representative quaternary ammonium cationic surfactant, on nutrient removal by Chlorella vulgaris F1068. Results showed that when the concentration of CTAB was less than 10 ng/L, the cellular components chlorophyll a, proteins, polysaccharides, and total lipids increased by 10.11, 58.17, 38.78, and 11.87 %, respectively, and some enzymes in nutrient metabolism of algal cells, such as glutamine synthetase (GS), acid phosphatase (ACP), H(+)-ATPase, and esterase, were also enhanced. As a result, the removal efficiencies of ammonia nitrogen (NH4 (+)) and total phosphorus (TP) increased by 14.66 and 8.51 %, respectively, compared to the control during a 7-day test period. The underlying mechanism was mainly due to an enhanced photosynthetic activity of C. vulgaris F1068 indicated by the increase in chlorophyll fluorescence parameters (the value of Fv/Fm, ΦII, Fv/Fo, and rETR increased by 12.99, 7.56, 25.59, and 8.11 %, respectively) and adenylate energy charge (AEC) (from 0.68 to 0.72). These results suggest that hormesis induced by trace toxicants could enhance the nutrient removal, which would be further considered in the design of municipal wastewater treatment processes. Graphical abstract The schematic mechanism of C. vulgaris F1068 under CTAB induced hormesis. Green arrows ( ) represent the increase and the red arrow ( ) represents the decrease.

  8. Awareness of hormesis will enhance future research in basic and applied neuroscience. (United States)

    Mattson, Mark P


    Hormesis is defined operationally as responses of cells or organisms to an exogenous or intrinsic factor (chemical, temperature, psychological challenge, etc.) in which the factor induces stimulatory or beneficial effects at low doses and inhibitory or adverse effects at high doses. The compendium of articles by Calabrese entitled "Neuroscience and Hormesis" provides a broad range of examples of neurobiological processes and responses to environmental factors that exhibit biphasic dose responses, the signature of hormesis. Nerve cell networks are the "first responders" to environmental challenges--they perceive the challenge and orchestrate coordinated adaptive responses that typically involve autonomic, neuroendocrine, and behavioral changes. In addition to direct adaptive responses of neurons to environmental stressors, cells subjected to a stressor produce and release molecules such as growth factors, cytokines, and hormones that alert adjacent and even distant cells to impending danger. The discoveries that some molecules (e.g., carbon monoxide and nitric oxide) and elements (e.g., selenium and iron) that are toxic at high doses play fundamental roles in cellular signaling or metabolism suggest that during evolution, organisms (and their nervous systems) co-opted environmental toxins and used them to their advantage. Neurons also respond adaptively to everyday stressors, including physical exercise, cognitive challenges, and dietary energy restriction, each of which activates pathways linked to the production of neurotrophic factors and cellular stress resistance proteins. The development of interventions that activate hormetic signaling pathways in neurons is a promising new approach for the preventation and treatment of a range of neurological disorders.

  9. Transgenerational shifts in reproduction hormesis in green peach aphid exposed to low concentrations of imidacloprid. (United States)

    Ayyanath, Murali-Mohan; Cutler, G Christopher; Scott-Dupree, Cynthia D; Sibley, Paul K


    Hormesis is a biphasic phenomenon that in toxicology is characterized by low-dose stimulation and high-dose inhibition. It has been observed in a wide range of organisms in response to many chemical stressors, including insects exposed to pesticides, with potential repercussions for agriculture and pest management. To address questions related to the nature of the dose-response and potential consequences on biological fitness, we examined transgenerational hormesis in the green peach aphid, Myzus persicae, when exposed to sublethal concentrations of the insecticide imidacloprid. A hormetic response in the form of increased reproduction was consistently observed and a model previously developed to test for hormesis adequately fit some of our data. However, the nature of the dose-response differed within and across generations depending upon the duration and mode of exposure. Decreased reproduction in intermediate generations confirmed that fitness tradeoffs were a consequence of the hormetic response. However, recovery to levels of reproduction equal to that of controls in subsequent generations and significantly greater total reproduction after four generations suggested that biological fitness was increased by exposure to low concentrations of the insecticide, even when insects were continuously exposed to the stressor. This was especially evident in a greenhouse experiment where the instantaneous rate of population increase almost doubled and total aphid production more than quadrupled when aphids were exposed to potato plants systemically treated with low amounts of imidacloprid. Our results show that although fitness tradeoffs do occur with hormetic responses, this does not necessarily compromise overall biological fitness.

  10. Hormesis and Paradoxical Effects of Drooping Birch (Betula pendula Roth Parameters Under Motor Traffic Pollution

    Directory of Open Access Journals (Sweden)

    Elena A. Erofeeva


    Full Text Available Various plant indexes are used or recommended for bioindication. However, the nonmonotonic dose–response dependences (hormesis and paradoxical effects of these indexes are insufficiently explored upon exposure to pollution. We studied the dependences of these Betula pendula indexes on the intensity of motor traffic pollution. Regression analysis did not reveal any dependence of chlorophyll and carotenoid content on traffic intensity (in 2008 and 2010-2013. Lipid peroxidation rate had different versions of paradoxical effects in 2008 and 2010 to 2012 and increased in comparison with control under an increase in pollution level in 2013. In 2010 to 2012, all dose–response dependences for total protein and thiol group content were biphasic and multiphasic paradoxical effects. In 2013, an increase in traffic intensity induced a linear reduction in protein content and an increase in thiol group level in comparison with the control. In most cases, the studied phenological indexes and seed production decreased monotonically in comparison with the control following an increase in traffic intensity. Only in 2010 and 2013, share of fallen leaves had hormesis and paradoxical effect accordingly. Fluctuating asymmetry had a paradoxical effect and hormesis in 2008 and 2012, accordingly, and increased in comparison with the control under an increase in the level of pollution in 2010 to 2011.

  11. Hormesis and Paradoxical Effects of Drooping Birch (Betula pendula Roth) Parameters Under Motor Traffic Pollution. (United States)

    Erofeeva, Elena A


    Various plant indexes are used or recommended for bioindication. However, the nonmonotonic dose-response dependences (hormesis and paradoxical effects) of these indexes are insufficiently explored upon exposure to pollution. We studied the dependences of these Betula pendula indexes on the intensity of motor traffic pollution. Regression analysis did not reveal any dependence of chlorophyll and carotenoid content on traffic intensity (in 2008 and 2010-2013). Lipid peroxidation rate had different versions of paradoxical effects in 2008 and 2010 to 2012 and increased in comparison with control under an increase in pollution level in 2013. In 2010 to 2012, all dose-response dependences for total protein and thiol group content were biphasic and multiphasic paradoxical effects. In 2013, an increase in traffic intensity induced a linear reduction in protein content and an increase in thiol group level in comparison with the control. In most cases, the studied phenological indexes and seed production decreased monotonically in comparison with the control following an increase in traffic intensity. Only in 2010 and 2013, share of fallen leaves had hormesis and paradoxical effect accordingly. Fluctuating asymmetry had a paradoxical effect and hormesis in 2008 and 2012, accordingly, and increased in comparison with the control under an increase in the level of pollution in 2010 to 2011.

  12. Hormesis on life-history traits: is there such thing as a free lunch? (United States)

    Jager, Tjalling; Barsi, Alpar; Ducrot, Virginie


    The term "hormesis" is used to describe dose-response relationships where the response is reversed between low and high doses of a stressor (generally, stimulation at low doses and inhibition at high ones). A mechanistic explanation is needed to interpret the relevance of such responses, but there does not appear to be a single universal mechanism underlying hormesis. When the endpoint is a life-history trait such as growth or reproduction, a stimulation of the response comes with costs in terms of resources. Organisms have to obey the conservation laws for mass and energy; there is no such thing as a free lunch. Based on the principles of Dynamic Energy Budget theory, we introduce three categories of explanations for hormesis that obey the conservation laws: acquisition (i.e., increasing the input of energy into the individual), allocation (i.e., rearranging the energy flows over various traits) and medication (e.g., the stressor is an essential element or acts as a cure for a disease or infection). In this discussion paper, we illustrate these explanations with cases where they might apply, and elaborate on the potential consequences for field populations.

  13. Exploring Child Play within the Framework of Cultural-Historical Psychology: Experience and Perspectives

    Directory of Open Access Journals (Sweden)

    L.I. Elkoninova


    Full Text Available The paper reconstructs the history of the problem of the development of mind on the example of child play. It reveals how researchers from the cultural-historical school of thought explored the developmental function of play, recorded quantitative leaps in its development and attempted to reconstruct it — from the works of L.S. Vygotsky and his followers (activity approach to role play: A.N. Leontiev, D.B. Elkonin, N.Ya. Mikhaylenko, N.A. Korotkova and others to the works of researchers who studied the very act of development in play (L.I. Elkoninova, T.V. Bazhanova, K.O. Yuryeva. It is argued that the concept of the cultural form of play that contains the Challenge (limited by possibilities of action, by risk and the Response to it serves as a foundation not only for role-playing games, but also for games with rules and computer games too. The Challenge is associated with action which transforms the situation of acting and is typical of all forms of play that are required to tie together everything that is separated in an everyday behavior of a child.

  14. Clinical manifestations of hysteria: an epistemological perspective or how historical dynamics illuminate current practice. (United States)

    Medeiros De Bustos, Elisabeth; Galli, Sylvio; Haffen, Emmanuel; Moulin, Thierry


    Hysteria has generated the most heated debates among physicians, from antiquity to the present day. It has been long confused with neuroses and neurological pathologies such as Parkinson's disease and epilepsy, principally associated with women and sexual disorders. The clinical manifestations must first be seen in their historical context, as interpretation varies according to the time period. Recently, the Diagnostic and Statistical Manual of Mental Disorders by the American Psychiatric Association marked a break in the consensus that previously seemed to apply to the concept of hysteria and approach to the clinical manifestations. The clinical manifestations of hysteria are numerous and multifaceted, comprising 3 main classifications: paroxysms, attacks, and acute manifestations; long-lasting functional syndromes, and visceral events. Each main classification can be subdivided into several subgroups. The first main group of paroxysms, attacks, and acute manifestations includes major hysterical attacks, such as prodrome, trance and epileptic states, minor hysterical attacks such as syncope and tetany, twilight states, paroxysmal amnesia, and cataleptic attacks. The second group includes focal hysterical symptoms, paralyses, contractures and spasms, anesthesia, and sensory disorders. Visceral manifestations can be subdivided into spasms, pain, and general and trophic disorders. The diversity of the symptoms of hysteria and its changing clinical presentation calls into question the same hysterical attacks and the same symptoms, which have had only a few differences for over 2,000 years. A new definition of hysteria should be proposed, in that it is a phenomenon that is not pathological, but physiological and expressional.

  15. Historical Perspectives and Future Needs in the Development of the Soil Series Concept (United States)

    Beaudette, Dylan E.; Brevik, Eric C.; Indorante, Samuel J.


    The soil series concept is an ever-evolving understanding of soil profile observations, their connection to the landscape, and functional limits on the range in characteristics that affect management. Historically, the soil series has played a pivotal role in the development of soil-landscape theory, modern soil survey methods, and concise delivery of soils information to the end-user-- in other words, soil series is the palette from which soil survey reports are crafted. Over the last 20 years the soil series has received considerable criticism as a means of soil information organization (soil survey development) and delivery (end-user application of soil survey data), with increasing pressure (internal and external) to retire the soil series. We propose that a modern re-examination of soil series information could help address several of the long-standing critiques of soil survey: consistency across survey vintage and political divisions and more robust estimates of soil properties and associated uncertainty. A new library of soil series data would include classic narratives describing morphology and management, quantitative descriptions of soil properties and their ranges, graphical depiction of the relationships between associated soil series, block diagrams illustrating soil-landscape models, maps of series distribution, and a probabilistic representation of a "typical" soil profile. These data would be derived from re-correlation of existing morphologic and characterization data informed by modern statistical methods and regional expertise.

  16. The evolution of the Japanese medical education system: a historical perspective. (United States)

    Kuwabara, Norimitsu; Yamashita, Miu; Yee, Keolamau; Kurahara, David


    The Japanese Medical Education system has been influenced by political events throughout the country's history. From long periods of isolation from the western world to the effect of world wars, Japan's training system for physicians has had to adapt in many ways and will continue to change. The Japanese medical education system was recently compared to the "Galapagos Islands" for its unusual and singular evolution, in a speech by visiting professor Dr. Gordon L. Noel at the University of Tokyo International Research center.1 Japanese medical schools are currently working to increase their students' clinical hours or else these students may not be able to train in the United States for residencies. Knowing the history of the Japanese Medical education system is paramount to understanding the current system in place today. Studying the historical foundation of this system will also provide insight on how the system must change in order to produce better clinicians. This article provides a glimpse into the medical system of another nation that may encourage needed reflection on the state of current healthcare training in the United States.

  17. Source and fate of hydraulic fracturing water in the Barnett Shale: a historical perspective. (United States)

    Nicot, Jean-Philippe; Scanlon, Bridget R; Reedy, Robert C; Costley, Ruth A


    Considerable controversy continues about water availability for and potential impacts of hydraulic fracturing (HF) of hydrocarbon assets on water resources. Our objective was to quantify HF water volume in terms of source, reuse, and disposal, using the Barnett Shale in Texas as a case study. Data were obtained from commercial and state databases, river authorities, groundwater conservation districts, and operators. Cumulative water use from ∼ 18,000 (mostly horizontal) wells since 1981 through 2012 totaled ∼ 170,000 AF (210 Mm(3)); ∼ 26 000 AF (32 Mm(3)) in 2011, representing 32% of Texas HF water use and ∼ 0.2% of 2011 state water consumption. Increase in water use per well by 60% (from 3 to 5 Mgal/well; 0.011-0.019 Mm(3)) since the mid-2000s reflects the near-doubling of horizontal-well lengths (2000-3800 ft), offset by a reduction in water-use intensity by 40% (2000-1200 gal/ft; 2.5-1.5 m(3)/m). Water sources include fresh surface water and groundwater in approximately equal amounts. Produced water amount is inversely related to gas production, exceeds HF water volume, and is mostly disposed in injection wells. Understanding the historical evolution of water use in the longest-producing shale play is invaluable for assessing its water footprint for energy production.

  18. Vectorcardiographic diagnostic & prognostic information derived from the 12-lead electrocardiogram: Historical review and clinical perspective. (United States)

    Man, Sumche; Maan, Arie C; Schalij, Martin J; Swenne, Cees A


    In the course of time, electrocardiography has assumed several modalities with varying electrode numbers, electrode positions and lead systems. 12-lead electrocardiography and 3-lead vectorcardiography have become particularly popular. These modalities developed in parallel through the mid-twentieth century. In the same time interval, the physical concepts underlying electrocardiography were defined and worked out. In particular, the vector concept (heart vector, lead vector, volume conductor) appeared to be essential to understanding the manifestations of electrical heart activity, both in the 12-lead electrocardiogram (ECG) and in the 3-lead vectorcardiogram (VCG). Not universally appreciated in the clinic, the vectorcardiogram, and with it the vector concept, went out of use. A revival of vectorcardiography started in the 90's, when VCGs were mathematically synthesized from standard 12-lead ECGs. This facilitated combined electrocardiography and vectorcardiography without the need for a special recording system. This paper gives an overview of these historical developments, elaborates on the vector concept and seeks to define where VCG analysis/interpretation can add diagnostic/prognostic value to conventional 12-lead ECG analysis.

  19. Pelvic Fixation in Adult and Pediatric Spine Surgery: Historical Perspective, Indications, and Techniques: AAOS Exhibit Selection. (United States)

    Jain, Amit; Hassanzadeh, Hamid; Strike, Sophia A; Menga, Emmanuel N; Sponseller, Paul D; Kebaish, Khaled M


    Achieving solid osseous fusion across the lumbosacral junction has historically been, and continues to be, a challenge in spine surgery. Robust pelvic fixation plays an integral role in achieving this goal. The goals of this review are to describe the history of and indications for spinopelvic fixation, examine conventional spinopelvic fixation techniques, and review the newer S2-alar-iliac technique and its outcomes in adult and pediatric patients with spinal deformity. Since the introduction of Harrington rods in the 1960s, spinal instrumentation has evolved substantially. Indications for spinopelvic fixation as a means to achieve lumbosacral arthrodesis include a long arthrodesis (five or more vertebral levels) or use of three-column osteotomies in the lower thoracic or lumbar spine, surgical treatment of high-grade spondylolisthesis, and correction of lumbar deformity and pelvic obliquity. A variety of techniques have been described over the years, including Galveston iliac rods, Jackson intrasacral rods, the Kostuik transiliac bar, iliac screws, and S2-alar-iliac screws. Modern iliac screws and S2-alar-iliac screws are associated with relatively low rates of pseudarthrosis. S2-alar-iliac screws have the advantages of less implant prominence and inline placement with proximal spinal anchors. Collectively, these techniques provide powerful methods for obtaining control of the pelvis in facilitating lumbosacral arthrodesis.

  20. Has player development in men's tennis really changed? An historical rankings perspective. (United States)

    Bane, Michael Kenneth; Reid, Machar; Morgan, Stuart


    Tennis federations are regularly faced with decisions regarding which athletes should be supported in financial terms, and for how long. The financial investments can be considerable, given the cost of competing on tour has been estimated at a minimum $121,000 per year and only the top 130 professionally ranked athletes earned enough prize money to cover this cost in 2012. This study investigates key points of progression in tennis players' careers, to determine how these have changed over time and how that evolution may inform talent development. Approximately 400,000 weekly rankings for 273 male professional tennis players between 1985 and 2010 were compiled, and historical trends in the time taken to reach career milestones were investigated by least-squares regression. The time between earning a first professional ranking point and entry into the Top 100 significantly increased over time for all considered athletes. This was at the detriment of time spent within the Top 100 for some athletes. Career peak Top 50-100 athletes have shown an increase in longevity. These results assist tennis federations in assessing the progress of developing athletes and highlight the evolving nature of the competition for top players.

  1. Historical perspective: The problem of the origin of life in the context of developments in biology (United States)

    Kamminga, Harmke


    The structure of the history of scientific ideas on the origin of life, after Darwin's theory of evolution brought the problem into focus, is discussed. 19th-century theories in the mainstream of historical development already included some notion of chemical evolution. These theories were limited, however, by their reliance on a protoplasmic view of life, according to which the protoplasmic substance combines all vital properties. It was only when this holistic concept of protoplasm was abandoned that a clear distinction between different vital functions such as metabolism and replication was made. This led to two schools of thought in the origin of life field, one inspired by biochemistry and one by genetics. Oparin's theory, which was rooted in the metabolic traditions of biochemistry, provided a model which has had a lasting impact in methodological terms and which helped to transform the field from a largely theoretical one to an area of active research. Genetically based theories, on the other hand, had a delayed impact in this respect, because of long-lasting uncertainty regarding the structural basis of gene function.

  2. The midwives ordinance of Palestine, 1929: historical perspectives and current lessons. (United States)

    Katvan, Eyal; Bartal, Nira


    Until 1929, midwifery in Palestine was relatively open to anyone and only partially regulated by the 1918 Public Health Ordinance, legislated shortly after the beginning of British rule. This article describes the factors that guided the shaping of midwifery and suggests possible sources of inspiration for the British legislator in crafting the Midwives Ordinance in 1929, including American, local (Jews and Arabs), and British ones. The Midwives Ordinance reflects the adjustment of midwifery to changes in the society that evolved under the British Mandate. The ordinance shows how the modern midwife's role contracted relative to the traditional one, in the context of social processes in other countries, east and west. This historical research project is based on interviews, archive documents and research literature. It analyzes the British interests in regulating midwifery, including the rationale of preserving public health and reducing infant mortality, against a background of political power struggles as well as cultural, social and professional diversity in Palestine (the tensions between the powers of doctors, nurses, and pharmacists).

  3. Foul weather friends: big business and health care reform in the 1990s in historical perspective. (United States)

    Swenson, Peter; Greer, Scott


    Existing accounts of the Clinton health reform efforts of the early 1990s neglect to examine how the change in big business reform interests during the short period between the late 1980s and 1994 might have altered the trajectory of compulsory health insurance legislation in Congress. This article explores evidence that big employers lost their early interest in reform because they believed their private remedies for bringing down health cost inflation were finally beginning to work. This had a discouraging effect on reform efforts. Historical analysis shows how hard times during the Great Depression also aligned big business interests with those of reformers seeking compulsory social insurance. Unlike the present case, however, the economic climate did not quickly improve, and the social insurance reform of the New Deal succeeded. The article speculates, therefore, that had employer health expenditures not flattened out, continuing and even growing big business support might have neutralized small business and other opposition that contributed heavily to the failure of reform. Thus in light of the Clinton administration's demonstrated willingness to compromise with business on details of its plan, some kind of major reform might have succeeded.

  4. Stem cells and the reproductive system: historical perspective and future directions. (United States)

    Duke, Cindy M P; Taylor, Hugh S


    Recent findings in stem cell biology have presented new perspectives and opportunities for the treatment of reproductive disease. In a departure from the long held dogma of embryologically fixed numbers of oocytes, current literature suggests that human ovaries contain stem cells which form new oocytes even in adulthood and that these stem cells can be cultured in vitro to develop into mature oocytes. These findings have provided new hope and broader options for fertility preservation. Evidence of endometrial regeneration by bone marrow stem cells in endometrial tissue of women who received bone marrow transplant highlight potential for the novel treatments of uterine disorders and supports new theories for the etiology of endometriosis - ectopic transdifferentiation of stem cells. Further, endometrial derived stem cells have been demonstrated to be useful in the treatment of several chronic and often debilitating diseases, including Parkinson's Disease and Diabetes. Other cells that may present future therapeutic benefits for a myriad of disease states include placental and fetal cells which enter maternal circulation during pregnancy and can later promote parenchymal regeneration in maternal tissue. These findings highlight novel functions of the uterus and ovaries. They demonstrate that the uterus is a dynamic organ permeable to fetal stem cells capable of transdifferentiation as well as a renewable source of multipotent stem cells. While we still have much to understand about stem cells, their potential applications in reproductive biology and medicine are countless.

  5. Non-marital pregnancy and the second demographic transition in Australia in historical perspective

    Directory of Open Access Journals (Sweden)

    Gordon Carmichael


    Full Text Available Background: Australia has remarkably detailed data on non-marital pregnancy dating from 1908. They both offer insight into long-term trends in childbearing resulting from non-marital sexual activity and reveal in historical context key features of the second demographic transition and its genesis. Objective: Trends are traced in rates of non-marital conception of children ultimately born both outside and within marriage. A range of related indices is also presented in examining how demographic behaviour surrounding non-marital pregnancy (i helped generate the second demographic transition and (ii unfolded as a component of it. Methods: Core indices are rates of non-marital conception partitioned into additive components associated with marital and non-marital confinement. Data on non-marital and early marital births (at marriage durations 0-7 months are lagged back 38 weeks to a date of and age at conception basis to facilitate a common, unmarried, population at risk. Results: Post-war weakening of parental oversight of courtship was a fundamental trigger to the broader rejection of normative and institutional values that underpinned the second demographic transition. In tandem with denying the unmarried access to oral contraception it generated rampant youthful non-marital pregnancy, which undermined Judeo-Christian values, especially once abortion law reform occurred. Conclusions: Childbearing following non-marital conception transitioned rapidly after the 1960s from primarily the unintended product of youthful intercourse in non-coresidential relationships to mainly intended behaviour at normative reproductive ages in consensual unions. Family formation increasingly mixed non-marital births and premaritally and/or maritally conceived marital births.

  6. Skyscape of an Amazonian Diaspora: Arawak Astronomy in Historical Comparative Perspective (United States)

    Jara, Fabiola

    The title of this article "Arawak Astronomy" suggests that the research matter concerns the astronomy of an already well-defined ethnographic entity. This however does not do justice to the complexities of Arawak (pre)history. This contribution aims to discuss and connect the available historical and ethnographic data on Arawak astronomies as gathered by the author (Jara 2000), with the most recent research on the archeology and comparative linguistics of the Arawak diaspora. The article argues that Arawak astronomy has to be related to the cultural and sociopolitical continuities and discontinuities of the Arawak diaspora throughout the lowlands of tropical South America. This article recognizes the need to consider Arawak astronomy has an object to be discovered and explained within its local and regional contexts. Notwithstanding these remarks, based on a sustained examination of ethnohistorical and ethnographic sources, this article proposes that Arawak astronomy can be characterized by at least four elements: firstly, a horizon system of observation which combines the observation of the solar solstices and equinoxes with the near heliacal and near cosmic rising or setting of at least seven star groups - the Pleiades, the Hyades, the upper stars of the constellation of Scorpius (including α Sco), Corvus, the Belt of Orion, several stars near Sirius, and the Milky Way. Secondly, the association of the rising and setting of these star groups with the seasonal cycle, mainly with the start and/or of the end of rainy and dry seasons. Thirdly, the widespread association of the stars of the year (most commonly the Pleiades but sometimes Orion or the head of Scorpius) with the beginning of the agricultural cycle and consequently with the end of the heavy rains announcing the time to plant the new fields. The last and fourth commonality are the inscriptions or markings of the origin of the stars in the local landscape, lakes, mountains, and other salient landscape

  7. The Cultural Industry and educational criticism in Latin America: A Historical Perspective

    Directory of Open Access Journals (Sweden)

    Miguel Ángel Soto Sandoval


    Full Text Available The purpose of this article is to study three authors from different academic fields who have contributed to the development of educational knowledge systems in Latin America in the areas of culture, media communication, and education. In order to do so, I will first explore a historical study about the importance of the Cultural Industry in Latin America, based on academic contributions by Andres Bello, who focused intellectually to give cohesion to national unity in the recently established XIX century Latin American states. Enlightened culture emerges from its written and spoken language, and with support of the media at the time, the “bellista project” would become the first media communication and educational strategy aimed at capturing the new and varied dimensions of a nascent South American Culture. Similarly and in the same vein, I will look into the stance of writers and journalists, José Martí and Rubén Darío, who had to face Modernity as it began to replace the Enlightenment for a Culture for the Masses. Their poems and writings in newspapers back then, established an academic standpoint, for the first time, linked to media analysis and education, such as questioning the cultural industry and media narratives that were operating towards the end of the XIX century, in different media outlets. Finally, I examine how media analysis in Latin America emerged in the face of processes of domination that came not only from the economic but the so called cultural industries that surfaced with so much power in the mid-twentieth century. These media outlets show cultural processes as a marketable product while diluting the true real dimensions of culture.

  8. A historical perspective on protein crystallization from 1840 to the present day. (United States)

    Giegé, Richard


    Protein crystallization has been known since 1840 and can prove to be straightforward but, in most cases, it constitutes a real bottleneck. This stimulated the birth of the biocrystallogenesis field with both 'practical' and 'basic' science aims. In the early years of biochemistry, crystallization was a tool for the preparation of biological substances. Today, biocrystallogenesis aims to provide efficient methods for crystal fabrication and a means to optimize crystal quality for X-ray crystallography. The historical development of crystallization methods for structural biology occurred first in conjunction with that of biochemical and genetic methods for macromolecule production, then with the development of structure determination methodologies and, recently, with routine access to synchrotron X-ray sources. Previously, the identification of conditions that sustain crystal growth occurred mostly empirically but, in recent decades, this has moved progressively towards more rationality as a result of a deeper understanding of the physical chemistry of protein crystal growth and the use of idea-driven screening and high-throughput procedures. Protein and nucleic acid engineering procedures to facilitate crystallization, as well as crystallization methods in gelled-media or by counter-diffusion, represent recent important achievements, although the underlying concepts are old. The new nanotechnologies have brought a significant improvement in the practice of protein crystallization. Today, the increasing number of crystal structures deposited in the Protein Data Bank could mean that crystallization is no longer a bottleneck. This is not the case, however, because structural biology projects always become more challenging and thereby require adapted methods to enable the growth of the appropriate crystals, notably macromolecular assemblages.

  9. Future energy shifts in historical perspective; Framtida energiomstaellningar i historiskt perspektiv

    Energy Technology Data Exchange (ETDEWEB)

    Kaijser, Arne; Kander, Astrid


    The purpose of this report is to summarize the knowledge about historical changes that may be relevant to assess the opportunities and challenges that climate policy faces when it should steer towards future radical changes of infrastructure and energy systems. Scenarios for these transitions and change strategies for implementing them are presented including in the reports 'Two-degree target in sight? Scenarios for Swedish energy and transport by 2050' and 'Choice of path to 2050 - Governance challenges and change strategies for a transition to a carbon constrained society'. In this report, we analyze a number of major changes since the mid-1800s. These changes are of two types: on one hand what we call tailwind changes, on the other hand what we call head wind changes. Tailwind changes have been initiated by fundamental technological innovation and has led to growth opportunities and benefits for both the individual and for the economy. Head wind changes was initiated by crises in the world of various types and can be viewed as the necessity forced conversions where there is in the short and medium term, only losses. Any such change are treated both qualitatively and quantitatively: what institutional conditions were important conditions or obstacles, and how change can be described using different indicators. The main focus is on changes in Sweden, but since these processes are included in international development, we also make outlooks outside Sweden to clarify characteristics in Sweden and to discuss the reasons why some countries were converted faster than others.

  10. Childhood central nervous system leukemia: historical perspectives, current therapy, and acute neurological sequelae

    Energy Technology Data Exchange (ETDEWEB)

    Laningham, Fred H. [St. Jude Children' s Research Hospital, Division of Diagnostic Imaging, Department of Radiological Sciences, Memphis, TN (United States); University of Tennessee Health Sciences Center, Memphis, TN (United States); Kun, Larry E. [St. Jude Children' s Research Hospital, Division of Radiation Oncology, Department of Radiological Sciences, Memphis, TN (United States); University of Tennessee Health Sciences Center, Memphis, TN (United States); Reddick, Wilburn E.; Ogg, Robert J. [St. Jude Children' s Research Hospital, Division of Translational Imaging Research, Department of Radiological Sciences, Memphis, TN (United States); Morris, E.B. [St. Jude Children' s Research Hospital, Department of Oncology, Memphis, TN (United States); Pui, Ching-Hon [St. Jude Children' s Research Hospital, Department of Oncology, Memphis, TN (United States); University of Tennessee Health Sciences Center, Memphis, TN (United States)


    During the past three decades, improvements in the treatment of childhood leukemia have resulted in high cure rates, particularly for acute lymphoblastic leukemia (ALL). Unfortunately, successful therapy has come with a price, as significant morbidity can result from neurological affects which harm the brain and spinal cord. The expectation and hope is that chemotherapy, as a primary means of CNS therapy, will result in acceptable disease control with less CNS morbidity than has been observed with combinations of chemotherapy and radiotherapy over the past several decades. In this review we discuss the poignant, historical aspects of CNS leukemia therapy, outline current methods of systemic and CNS leukemia therapy, and present imaging findings we have encountered in childhood leukemia patients with a variety of acute neurological conditions. A major objective of our research is to understand the neuroimaging correlates of acute and chronic effects of cancer and therapy. Specific features related to CNS leukemia and associated short-term toxicities, both disease- and therapy-related, are emphasized in this review with the specific neuroimaging findings. Specific CNS findings are similarly important when treating acute myelogenous leukemia (AML), and details of leukemic involvement and toxicities are also presented in this entity. Despite contemporary treatment approaches which favor the use of chemotherapy (including intrathecal therapy) over radiotherapy in the treatment of CNS leukemia, children still occasionally experience morbid neurotoxicity. Standard neuroimaging is sufficient to identify a variety of neurotoxic sequelae in children, and often suggest specific etiologies. Specific neuroimaging findings frequently indicate a need to alter antileukemia therapy. It is important to appreciate that intrathecal and high doses of systemic chemotherapy are not innocuous and are associated with acute, specific, recognizable, and often serious neurological

  11. Selective elimination of breast cancer surgery in exceptional responders: historical perspective and current trials. (United States)

    van la Parra, Raquel F D; Kuerer, Henry M


    With improvements in chemotherapy regimens, targeted therapies, and our fundamental understanding of the relationship of tumor subtype and pathologic complete response (pCR), there has been dramatic improvement in pCR rates in the past decade, especially among triple-negative and human epidermal growth factor receptor 2-positive breast cancers. Rates of pCR in these groups of patients can be in the 60 % range and thus question the paradigm for the necessity of breast and nodal surgery in all cases, particularly when the patient will be receiving adjuvant local therapy with radiotherapy. Current practice for patients who respond well to neoadjuvant chemotherapy (NCT) is often to proceed with the same breast and axillary procedures as would have been offered women who had not received NCT, regardless of the apparent clinical response. Given these high response rates in defined subgroups among exceptional responders it is appropriate to question whether surgery is now a redundant procedure in their overall management. Further, definitive radiation without surgical resection with or without systemic therapy has been proven effective for several other malignant disease sites including some stages of esophageal, anal, laryngeal, prostate, cervical, and lung carcinoma. The main impediments for potential elimination of surgery have been the fact that prior and current standard and functional breast imaging methods are incapable of accurate prediction of residual disease and that integrating percutaneous biopsy of the breast primary and nodes following NCT may circumvent this issue. This article highlights historical attempts at omission of surgery following NCT in an earlier era, the current status of breast and nodal imaging to predict residual carcinoma, and ongoing and planned trials designed to identify appropriate patients who might be selected for clinical trials designed to test the safety of selected elimination of breast cancer surgery in percutaneous image

  12. Is hormesis an underestimated factor in the development of herbicide resistance?

    Directory of Open Access Journals (Sweden)

    Belz, Regina G.


    Full Text Available The growing impact of herbicide resistant weeds increasingly affects weed management and the delay of resistance evolution has become a major task of chemical weed control. Hormesis and, thus, the phenomenon that low doses of herbicides can boost weed growth could be of importance in this regard since the recommended field rate may represent a low dose for weeds that have evolved resistance to the applied herbicide and, thus, a potential hormetic dose. Applying the field rate may thus not only directly select resistant biotypes, it may also indirectly promote the success and spread of resistant biotypes via hormesis. Nevertheless, hormetic effects in resistant weeds are hitherto merely randomly observed and, thus, a clear quantitative basis to judge the significance of hormesis for resistance evolution is lacking. Therefore, this study aimed at quantifying the degree and frequency of herbicide hormesis in sensitive and resistant weed species in order to provide a first indication of whether the phenomenon deserves consideration as a potential factor contributing to the development of herbicide resistance. In germination assays complete dose-response experiments were conducted with sensitive and resistant biotypes of Matricaria inodora (ALS-target-site resistant; treated with iodosulfuron-methyl-sodium/mesosulfuron-methyl, Eleusine indica (glyphosateresistant; treated with glyphosate, and Chenopodium album (triazine/triazinone-target-site resistant; treated with terbuthylazine. After 10 days of cultivation under controlled conditions plant growth was analyzed by measuring shoot/root length and mass. Results indicated that herbicide hormesis occurred on average with a total frequency of 29% in sensitive/resistant biotypes with an average growth increase of 53% occurring typically within a dose zone exceeding 350fold. Hormetic effects occurred, however, very variable and only for specific endpoints and not plant growth in general. If such a

  13. Hormesis-based anti-aging products: a case study of a novel cosmetic. (United States)

    Rattan, Suresh I S; Kryzch, Valérie; Schnebert, Sylvianne; Perrier, Eric; Nizard, Carine


    Application of hormesis in aging research and interventions is becoming increasingly attractive and successful. The reason for this is the realization that mild stress-induced activation of one or more stress response (SR) pathways, and its consequent stimulation of repair mechanisms, is effective in reducing the age-related accumulation of molecular damage. For example, repeated heat stress-induced synthesis of heat shock proteins has been shown to have a variety of anti-aging effects on growth and other cellular and biochemical characteristics of normal human skin fibroblasts, keratinocytes and endothelial cells undergoing aging in vitro. Therefore, searching for potential hormetins - conditions and compounds eliciting SR-mediated hormesis - is drawing attention of not only the researchers but also the industry involved in developing healthcare products, including nutriceuticals, functional foods and cosmeceuticals. Here we present the example of a skin care cosmetic as one of the first successful product developments incorporating the ideas of hormesis. This was based on the studies to analyse the molecular effects of active ingredients extracted from the roots of the Chinese herb Sanchi (Panax notoginseng) on gene expression at the level of mRNAs and proteins in human skin cells. The results showed that the ginsenosides extracted from Sanchi induced the transcription of stress genes and increased the synthesis of stress proteins, especially the heat shock protein HSP1A1 or Hsp70, in normal human keratinocytes and dermal fibroblasts. Furthermore, this extract also has significant positive effects against facial wrinkles and other symptoms of facial skin aging as tested clinically, which may be due to its hormetic mode of action by stress-induced synthesis of chaperones involved in protein repair and removal of abnormal proteins. Acceptance of such a hormesis-based product by the wider public could be instrumental in the social recognition of the concept of

  14. An inquiry into the causes for the multiple goals of the United States Antitrust Law from a historical perspective

    Institute of Scientific and Technical Information of China (English)

    Han Tie


    It is not the case as Robert Bork claims that the U.S.antitrust law had only one goal-maximization of consumer welfare of efficiency-at the very beginning and should have been kept that way for its later development.Partly because of the fighting among different interest groups as well as spokesmen of different regions at the 51 st Congress,the Sherman Antitrust Act came out as a legislation with multiple goals,which were also taking shape under the influence of the Republican idea of balance of power,the liberal belief in property rights,the freedom of contract of classic economics,and the price theory of neoclassic economics.In more than a hundred years after that,the U.S.antitrust law has shifted the center of its goals as a result of the change of regulatory regimes with different emphases such as market function,economic stabilization,social concern,and economic efficiency during different periods.From a historical perspective,it is beyond dispute that the U.S.antitrust law has had multiple goals instead of only one.

  15. Historical perspective on the synonymization of the four major pest species belonging to the Bactrocera dorsalis species complex (Diptera, Tephritidae). (United States)

    Hee, Alvin K W; Wee, Suk-Ling; Nishida, Ritsuo; Ono, Hajime; Hendrichs, Jorge; Haymer, David S; Tan, Keng-Hong


    An FAO/IAEA-sponsored coordinated research project on integrative taxonomy, involving close to 50 researchers from at least 20 countries, culminated in a significant breakthrough in the recognition that four major pest species, Bactrocera dorsalis, Bactrocera philippinensis, Bactrocera papayae and Bactrocera invadens, belong to the same biological species, Bactrocera dorsalis. The successful conclusion of this initiative is expected to significantly facilitate global agricultural trade, primarily through the lifting of quarantine restrictions that have long affected many countries, especially those in regions such as Asia and Africa that have large potential for fresh fruit and vegetable commodity exports. This work stems from two taxonomic studies: a revision in 1994 that significantly increased the number of described species in the Bactrocera dorsalis species complex; and the description in 2005 of Bactrocera invadens, then newly incursive in Africa. While taxonomically valid species, many biologists considered that these were different names for one biological species. Many disagreements confounded attempts to develop a solution for resolving this taxonomic issue, before the FAO/IAEA project commenced. Crucial to understanding the success of that initiative is an accounting of the historical events and perspectives leading up to the international, multidisciplinary collaborative efforts that successfully achieved the final synonymization. This review highlights the 21 year journey taken to achieve this outcome.

  16. Historical perspectives on typhoons and tropical storms in the natural and socio-economic system of Nam Dinh (Vietnam) (United States)

    Kleinen, John


    This contribution starts with a brief introduction of the effects of typhoons and tropical storms on Vietnam, focusing in particular on the coastal region of Nam Dinh, a province in the northern part of the country and part of the Red River Delta. The magnitude of damage caused by a natural disaster is not solely determined by the direct physical impact of the event, but also depends on the socio-economic and political circumstances that shape a person or a groups' daily life. Such conditions define where and how people live and work. An overview of the major events since the 19th century shows how important it is to study these events in historical perspective. This paper briefly considers various conceptualizations and definitions of vulnerability. It analyses the destruction caused by a natural disaster in terms of peoples' vulnerability in a deltaic region. A distinction is made between collective vulnerability and individual vulnerability, each leading to different levels of perception of the disaster. The levels overlap in the discussion because they are interwoven and dependent on one another.

  17. The nutrition and health impact of cash cropping in west Africa: a historical perspective. (United States)

    Brun, T A


    The impact of cash cropping in West Africa cannot be isolated from its social and historical background. Among the many changes brought to West African economies by cash cropping since the beginning of the century, the present document shows how the extension of trade with European merchants and colonizers created new sets of values and criteria for wealth. Food crops gradually lost their prominent cultural and economics roles to the benefit of export crops or goods. Traditional systems of agricultural production were profoundly disrupted by military actions. They imposed colonial rule and control of trade of tropical crops and goods. Forced labor and compulsory (poorly paid) work assignments were instituted for private and public enterprises: construction of roads, railways, public buildings and plantations. The main justification was the need for cheap labor to cultivate, transport and build roads for the extraction of raw materials. This in turn caused massive migrations from countries such as Burkina Faso (Upper Volta) to Ivory Coast. Cash cropping made systematic collection of taxes possible. An imposition on a per capita basis became the rule and the major incentive of small farmers to engage in commercial farming. Cash cropping made also possible extensive monetarization of West Africa. This results in both favorable and unfavorable effects on the quality of the diet. In profoundly disrupted traditional societies, the diffusion of new consumption patterns was easier and faster. It led to massive food imports of wheat, rice, sugar, alcohol, etc. Cash cropping was (and still is) practiced as a 'mining' agriculture, exhausting soils and deteriorating their fertility for extended periods of time. In the Sudanian and Sahelian zones cash cropping conflicted with the cultivation of grains because peak demands for labor were similar. Therefore, millet and sorghum production declined. Cash cropping was developed in response to the need of European economies for

  18. Herbicide hormesis to segregate a weed population? – A case study with Tripleurospermum perforatum (Mérat Lainz

    Directory of Open Access Journals (Sweden)

    Belz, Regina G.


    Full Text Available Weed populations feature within-population genetic differences. Thus, evaluating mean responses in herbicide treated populations may miss ecologically significant individual responses. Since hormesis can likewise vary between individuals, this study investigated the hypothesis that herbicide hormesis within a high-density weed population is different among slowly-growing individuals, as compared to fast-growing individuals. In a dose-response experiment, Tripleurospermum perforatum (Mérat Lainz was exposed to 12 doses of Atlantis WG (mesosulfuron + iodosulfuron in 24 replicates (50 plants/replicate. Root/shoot growth responses were evaluated as dose-response relationships for the population mean, the 90-97th percentile of the population (fast-growing individuals, and the 5-10th percentile (slow-growing individuals. Growth responses were generally biphasic. Slow-growing individuals had more pronounced hormesis that occurred partially at lower doses as compared to the population mean. With fast-growing individuals, hormesis was instead less pronounced and partially shifted to higher doses. Hence, hormesis was primarily associated with a stimulation of slow-growing individuals, while fast-growing individuals contributed to a lesser extent to the hormetic population response in a dense stand in vitro. This discrepancy may have the potential to segregate an herbicide exposed population and alter its sensitivity in the long-run.

  19. Hydrogen sulfide (H2S) and sour gas effects on the eye. A historical perspective. (United States)

    Lambert, Timothy William; Goodwin, Verona Marie; Stefani, Dennis; Strosher, Lisa


    The toxicology of hydrogen sulfide (H(2)S) and sour gas on the eye has a long history beginning at least with Ramazzini's observations [Ramazzini B. Diseases of Workers--De Morbis Artificum Diatriba--1713. Wright WC (trans). New York, C. Hafner Publishing Co Inc.; 1964. 98-99 pp.]. In contrast, a recent review by Alberta Health and Wellness (AHW Report) concluded that there is little evidence of eye irritation following short-term exposures to H(2)S at concentrations up to 100ppm and that the H(2)S literature on the eye is a series of unsubstantiated claims reproduced in review articles dating back to the 1930s [Alberta Health and Wellness (AHW report). Health effects associated with short-term exposure to low levels of hydrogen sulfide: a technical review, Alberta Health and Wellness, October 2002, 81pp.]. In this paper, we evaluated this claim through a historical review of the toxicology of the eye. Ramazzini noted the effects of sewer gas on the eye [Ramazzini B. Diseases of Workers--De Morbis Artificum Diatriba--1713. Wright WC (trans). New York, C. Hafner Publishing Co Inc. 1964. 98-99 pp.]. Lehmann experimentally showed eye effects in men at 70-90ppm H(2)S and also in animals [Lehmann K. Experimentalle Studien uber den Einfluss technisch und hygienisch wichtiger Gase und Dampfe auf den Organismus. Arch Hyg 1892;14:135-189]. In 1923, Sayers, Mitchell and Yant reported eye effects in animals and men at 50ppm H(2)S. Barthelemy showed eye effects in animals and men at 20ppm H(2)S [Barthelemy HL. Ten years' experience with industrial hygiene in connection with the manufacture of viscose rayon. J Ind Hyg Toxicol 1939;21:141-51]. Masure experimentally showed that H(2)S is the causative agent of eye impacts in animals and men [Masure R. La Keratoconjunctivite des filatures de viscose; etude clinique and experiementale. Rev Belge Pathol 1950;20:297-341]. Michal upon microscopic examination of the rat's cornea, found nuclear pyknosis, edema and separation of cells in

  20. Respiratory medicine and research at McGill University: A historical perspective (United States)

    Martin, James G; Schwartzman, Kevin


    , areas of particular clinical strength and investigation included asthma, occupational and immunological lung diseases. In 1989, the Meakins Christie Laboratories relocated to its current site on Rue St Urbain, adjacent to the Montreal Chest Institute. Dr Qutayba Hamid, on faculty at the Brompton Hospital, joined the Meakins-Christie Labs in 1994. In addition to an outstanding career in the area of the immunopathology of human asthma, he broadened the array of techniques routinely applied at the labs and has ably led the Meakins-Christie Labs from 2008 to the present. The Meakins Christie Laboratories have had a remarkable track record that continues to this day. The basis for its enduring success is not immediately clear but it has almost certainly been linked to the balance of MD and PhD scientists that brought perspective and rigour. The diverse disciplines and research programs also facilitated adaptation to changing external research priorities. The late 1990s and the early 21st century also saw the flourishing of the Respiratory Epidemiology Unit, under the leadership of Drs Pierre Ernst, Dick Menzies and Jean Bourbeau. It moved from McGill University to the Montreal Chest Institute in 2004. This paved the way for expanded clinical and translational research programs in COPD, tuberculosis, asthma, respiratory sleep disorders and other pulmonary diseases. The faculty now comprises respiratory clinician-researchers and PhD scientists with expertise in epidemiological methods and biostatistics. Respiratory physiology and medicine at McGill benefitted from a strong start through the influence of Meakins and Christie, and a tight linkage between clinical observation and physiological research. The subsequent recruitment of talented and creative faculty members with absolute dedication to academic medicine continued the legacy. No matter how significant the scientific contributions of the individuals themselves, their most important impact resulted from the training of a

  1. Bacterial, Fungal, and Parasitic Infections of the Central Nervous System: Radiologic-Pathologic Correlation and Historical Perspectives. (United States)

    Shih, Robert Y; Koeller, Kelly K


    Despite remarkable progress in prevention and treatment, infectious diseases affecting the central nervous system remain an important source of morbidity and mortality, particularly in less-developed countries and in immunocompromised persons. Bacterial, fungal, and parasitic pathogens are derived from living organisms and affect the brain, spinal cord, or meninges. Infections due to these pathogens are associated with a variety of neuroimaging patterns that can be appreciated at magnetic resonance imaging in most cases. Bacterial infections, most often due to Streptococcus, Haemophilus, and Neisseria species, cause significant meningitis, whereas the less common cerebritis and subsequent abscess formation have well-documented progression, with increasingly prominent altered signal intensity and corresponding contrast enhancement. Atypical bacterial infections are characterized by the development of a granulomatous response, classically seen in tuberculosis, in which the tuberculoma is the most common parenchymal form of the disease; spirochetal and rickettsial diseases are less common. Fungal infections predominate in immunocompromised hosts and are caused by yeasts, molds, and dimorphic fungi. Cryptococcal meningitis is the most common fungal infection, whereas candidiasis is the most common nosocomial infection. Mucormycosis and aspergillosis are characterized by angioinvasiveness and are associated with high morbidity and mortality among immunocompromised patients. In terms of potential exposure in the worldwide population, parasitic infections, including neurocysticercosis, toxoplasmosis, echinococcosis, malaria, and schistosomiasis, are the greatest threat. Rare amebic infections are noteworthy for their extreme virulence and high mortality. The objective of this article is to highlight the characteristic neuroimaging manifestations of bacterial, fungal, and parasitic diseases, with emphasis on radiologic-pathologic correlation and historical perspectives.

  2. On the genesis of heterogeneous photocatalysis: a brief historical perspective in the period 1910 to the mid-1980s. (United States)

    Serpone, N; Emeline, A V; Horikoshi, S; Kuznetsov, V N; Ryabchuk, V K


    The concept Photocatalysis and, of greater import here, Heterogeneous Photocatalysis were first introduced in the second decade (1910-1920) of the 20th century according to the CAPLUS and MEDLINE databases (SciFinder). This review reports a brief historical perspective on the origins of the two concepts, whether implied or explicitly stated, in some detail up to about the mid-1980s when heterogeneous photocatalysis witnessed the beginning of an exponential growth, with particular emphasis on the use of nanosized TiO(2) particles in powdered form as the (so-called) photocatalyst of choice in environmental applications because of its inherent properties of abundance and chemical stability in acidic and alkaline aqueous media (in the dark), in contrast to ZnO that had been the metal oxide of choice in the early days. The early workers in this area often used the term photosensitization rather than the current popular term photocatalysis, used since the early 1980s. The term Photocatalysis appeared in the literature as early as 1910 in a book by Plotnikow (Russia) and a few years later it was introduced in France by Landau. The review also reports on contributions during the early years by Terenin at the University of St. Petersburg (previously Leningrad, Soviet Union), and in the decade spanning 1975-1985 contributions by Bard's group at the University of Texas at Austin (USA) as well as those of other groups. Some activities into the conversion of light energy to chemical fuels (e.g. H(2)) during the 1975-1985 decade are also considered.

  3. Transgenerational shifts in reproduction hormesis in green peach aphid exposed to low concentrations of imidacloprid.

    Directory of Open Access Journals (Sweden)

    Murali-Mohan Ayyanath

    Full Text Available Hormesis is a biphasic phenomenon that in toxicology is characterized by low-dose stimulation and high-dose inhibition. It has been observed in a wide range of organisms in response to many chemical stressors, including insects exposed to pesticides, with potential repercussions for agriculture and pest management. To address questions related to the nature of the dose-response and potential consequences on biological fitness, we examined transgenerational hormesis in the green peach aphid, Myzus persicae, when exposed to sublethal concentrations of the insecticide imidacloprid. A hormetic response in the form of increased reproduction was consistently observed and a model previously developed to test for hormesis adequately fit some of our data. However, the nature of the dose-response differed within and across generations depending upon the duration and mode of exposure. Decreased reproduction in intermediate generations confirmed that fitness tradeoffs were a consequence of the hormetic response. However, recovery to levels of reproduction equal to that of controls in subsequent generations and significantly greater total reproduction after four generations suggested that biological fitness was increased by exposure to low concentrations of the insecticide, even when insects were continuously exposed to the stressor. This was especially evident in a greenhouse experiment where the instantaneous rate of population increase almost doubled and total aphid production more than quadrupled when aphids were exposed to potato plants systemically treated with low amounts of imidacloprid. Our results show that although fitness tradeoffs do occur with hormetic responses, this does not necessarily compromise overall biological fitness.

  4. Is the integration of hormesis and essentiality into ecotoxicology now opening Pandora's Box? (United States)

    Kefford, Ben J; Zalizniak, Liliana; Warne, Michael St J; Nugegoda, Dayanthi


    Hormesis and essentiality are likely real and common effects at the level of the individual. However, the widespread incorporation of stimulatory effects into applications of ecotoxicology requires the acceptance of assumptions, value judgements and possibly lowering of water/sediment quality standards. There is also currently little data appropriate for considering hormetic effects in the ecotoxicological context. Except perhaps in the case of fitting concentration-response curves, it is not clear that incorporation of hormetic and essentiality type responses into ecotoxicology is necessary. Furthermore, its incorporation presents considerable intellectual and practical changes for ecotoxicology and could have unanticipated consequences.

  5. Comments on Ortwin Renn's article 'Hormesis and risk communication': considerations about uncertainity, ignorance and governance. (United States)

    De Marchi, Bruna


    After acknowledging Renn's careful investigation and valuable insights, this paper expands on some issues that have been somewhat neglected in his account. It addresses the relationship between risk, uncertainity and ignorance in risk assessment, focusing in particular on the need to recognize that framing assumptions condition all subsequent steps. Subsequently, it discusses the implications for risk communication in the case of hormesis. The author maintains that problems of risk are strictly and irremediably intertwined with problems of governance. Therefore, she is doubtful that regulatory agencies would promote, and the public would welcome, modifications in current regimes on the basis of still limited and debated evidence of good.

  6. Forensic odontology, historical perspective. (United States)

    Sansare, K


    According to the old testament Adam was convinced by eve to put a "Bite Mark" on the apple. Interest in Forensic Odontology was heightened in the latter part of 19th Century. The first formal instructional programme was given at the Armed Forces Institute of Pathology, U.S. Since then the number of cases reported has played a significant role in expanding the role of Forensic Odontology. The earliest reported case was of Lollia Paulina in the year 49 A. D. One of the early reported case is also found in India in the year 1193. In the last few decades, the basic pattern of Forensic Odontology has changed quite a lot. Advances in dental material and laboratory techniques, with improvements in scientific and photographic technology, have made the proof of presentation much to forensic science.

  7. Diamond films: Historical perspective

    Energy Technology Data Exchange (ETDEWEB)

    Messier, R. [Pennsylvania State Univ., University Park (United States)


    This section is a compilation of notes and published international articles about the development of methods of depositing diamond films. Vapor deposition articles are included from American, Russian, and Japanese publications. The international competition to develop new deposition methodologies is stressed. The current status of chemical vapor deposition of diamond is assessed.

  8. Historical Perspective of COIL (United States)


    Chemically, these reactions should be about equal in rate. A recording mercury manometer was devised (we couldn’t afford a capacitance manometer) to measure... Mercury Manometer . Journal of Chemical Education, 1976. 14. McDermott, W.E., et al. Chemical Generation of Molecular 02( 1 Ag). in Summer Colloquium

  9. HBT Interferometry: Historical Perspective

    CERN Document Server

    Padula, S S


    I review the history of HBT interferometry, since its discovery in the mid 50's, up to the recent developments and results from BNL/RHIC experiments. I focus the discussion on the contributions to the subject given by members of our Brazilian group.

  10. Historical perspective of peptidomics

    Directory of Open Access Journals (Sweden)

    Michael Schrader


    Full Text Available Peptides have been studied for over 100 years, but for most of this time the focus was on a specific peptide or peptides, and not on the general peptidome of a biological sample. In the 1990s, mass spectrometry techniques were developed for the analysis of proteins, usually after digestion into peptides. The field of peptidomics started soon after proteomics and has grown to over 600 publications that use the word “peptidomic” or “peptidomics”. Although peptidomics is related to proteomics, there are fundamental differences. In this review, we discuss these differences along with the history of the field of peptidomics.

  11. Placebo, a historical perspective. (United States)

    Czerniak, Efrat; Davidson, Michael


    Substances and interventions with no specific therapeutic effect have been in use since the dawn of history. The term placebo has first been mentioned in the Scriptures, but it was not until the 19th century that it appeared in a medical context. Although lay people like Voltaire, and physicians such as Sir William Osler, have raised the possibility that much of what physicians did had no specific therapeutic effect, this notion was not shared by the public at large or by the medical profession. It was only by the end of the 18th century that a placebo-controlled trial has been conducted, repudiating the therapeutic effect of mesmerism. The advent, in the late 1940s, of effective treatments, which also had serious adverse effects, made the distinction between placebo and putative, active drug effects more relevant and urgent, and cleared the way for double-blind, randomized, placebo-controlled trials. This in turn triggered an ethical debate on the use of placebo, both in research and in clinical practice. Anthropologists, sociologists, physiologists, and medical researchers are all focusing their efforts on understanding the mechanism, role and modulating factors of placebo.

  12. STS Historical Perspectives. (United States)

    Lewis, A. O.


    Presented is a collection of poems from the seventeenth through nineteenth centuries that have asked questions about the social consequences of science and technology. Discussed are the beliefs of poets toward scientific knowledge and advances in technology. (KR)

  13. Transcript expression patterns illuminate the mechanistic background of hormesis in caenorhabditis elegans maupas. (United States)

    Steinberg, Christian E W; Pietsch, Kerstin; Saul, Nadine; Menzel, Stefanie; Swain, Suresh C; Stürzenbaum, Stephen R; Menzel, Ralph


    The animal model Caenorhabditis elegans was employed to study polyphenol- and humic substances-induced hormetic changes in lifespan. A detailed insight into the underlying mechanism of hormesis was uncovered by applying whole genome DNA microarray experimentation over a range of quercetin (Q), tannic acid (TA), and humic substances (HuminFeed(®), HF) concentrations. The transcriptional response to all exposures followed a non-linear mode which highlighted differential signaling and metabolic pathways. While low Q concentrations regulated processes improving the health of the nematodes, higher concentrations extended lifespan and modulated substantially the global transcriptional response. Over-represented transcripts were notably part of the biotransformation process: enhanced catabolism of toxic intermediates possibly contributes to the lifespan extension. The regulation of transcription, Dauer entry, and nucleosome suggests the presence of distinct exposure dependent differences in transcription and signaling pathways. TA- and HF-mediated transcript expression patterns were overall similar to each other, but changed across the concentration range indicating that their transcriptional dynamics are complex and cannot be attributed to a simple adaptive response. In contrast, Q-mediated hormesis was well aligned to fit the definition of an adaptive response. Simple molecules are more likely to induce an adaptive response than more complex molecules.

  14. Mitochondrial Hormesis in Pancreatic β Cells: Does Uncoupling Protein 2 Play a Role?

    Directory of Open Access Journals (Sweden)

    Ning Li


    Full Text Available In pancreatic β cells, mitochondrial metabolism translates glucose sensing into signals regulating insulin secretion. Chronic exposure of β cells to excessive nutrients, namely, glucolipotoxicity, impairs β-cell function. This is associated with elevated ROS production from overstimulated mitochondria. Mitochondria are not only the major source of cellular ROS, they are also the primary target of ROS attacks. The mitochondrial uncoupling protein UCP2, even though its uncoupling properties are debated, has been associated with protective functions against ROS toxicity. Hormesis, an adaptive response to cellular stresses, might contribute to the protection against β-cell death, possibly limiting the development of type 2 diabetes. Mitochondrial hormesis, or mitohormesis, is a defense mechanism observed in ROS-induced stress-responses by mitochondria. In β cells, mitochondrial damages induced by sublethal exogenous H2O2 can induce secondary repair and defense mechanisms. In this context, UCP2 is a marker of mitohormesis, being upregulated following stress conditions. When overexpressed in nonstressed naïve cells, UCP2 confers resistance to oxidative stress. Whether treatment with mitohormetic inducers is sufficient to restore or ameliorate secretory function of β cells remains to be determined.

  15. The notion of hormesis and the dose-response theory: a unified approach. (United States)

    Murado, M A; Vázquez, J A


    According to an opinion which is vigorous and insistently defended for approximately one decade, hormesis (the response of a biological entity to an effector, with stimulatory results at low doses and inhibitory results at high doses) radically puts into question the classic theory of dose-response (DR) relationships and demands a profound revision of environmental protection policies. Herein we show that DR theory, with the modifications which we propose, allows the modelling of various kinds of biphasic responses which are phenomenologically similar to hormetic ones and of well-defined origin, as well as responses which have been treated as genuinely hormetic. Our descriptive approach may also represent a useful resource for experimental design, directed towards identifying some of the potentially heterogeneous mechanisms which underlie the hormetic phenomenon. Finally, it also allows to discuss some factors which prevent the use of the notion of hormesis-perhaps useful in a clinical context, under strictly controlled conditions-to make decisions on environmental protection measures.

  16. Preconditioning is hormesis part I: Documentation, dose-response features and mechanistic foundations. (United States)

    Calabrese, Edward J


    This article provides the first extensive documentation of the dose response features of pre- and postconditioning. Pre- and postconditioning studies with rigorous study designs, using multiple doses/concentrations along with refined dose/concentration spacing strategies, often display hormetic dose/concentration response relationships with considerable generality across biological model, inducing (i.e., conditioning) agent, challenging dose treatment, endpoint, and mechanism. Pre- and postconditioning hormesis dose/concentration-response relationships are reported for 154 diverse conditioning agents, affecting more than 550 dose/concentration responses, across a broad range of biological models and endpoints. The quantitative features of the pre- and postconditioning-induced protective responses are modest, typically being 30-60% greater than control values at maximum, findings that are consistent with a large body (>10,000) of hormetic dose/concentration responses not related to pre- and postconditioning. Regardless of the biological model, inducing agent, endpoint or mechanism, the quantitative features of hormetic dose/concentration responses are similar, suggesting that the magnitude of response is a measure of biological plasticity. This paper also provides the first documentation that hormetic effects account for preconditioning induced early (1-3h) and delayed (12-72h) windows of protection. These findings indicate that pre- and postconditioning are specific types of hormesis.

  17. Reprint of: From the 90's to now: A brief historical perspective on more than two decades of estrogen neuroprotection (United States)

    Engler-Chiurazzi, E.B.; Singh, M.; Simpkins, J.W.


    Historical perspective abstract: From the 90's to now: a historical perspective on more than two decades of estrogen neuroprotection: In the early 90's, estrogens were known to exert organizational and activational effects on reproductive tissues and sexual behavior. As well, the role of sex and gonadal hormones in altering the risk for developing Alzheimer's Disease (AD) was only beginning to be elucidated. Preliminary investigations suggested that estrogen-containing therapies typically given for the management of disruptive menopausal symptoms could reduce AD risk, attenuate disease-associated cognitive deficits, and modulate brain substrates known to be dysregulated by the condition, such as the cholingeric system. The findings from our seminal paper demonstrating cognitive benefits and cholinergic impacts with exogenous estrogen treatment in a rodent model of surgical hormone depletion provided initial support for use of estrogen-containing therapies as a treatment for age-related brain disorders. We then went on to demonstrate neuroprotective actions of estrogen in several other in vivo and in vitro models of neurological challenge, including stroke and AD. Further, our findings of the chemical structure requirements for estrogen's neuroprotective effects identified a novel approach for optimizing future estrogen-containing hormone therapy options. These early efforts laid the groundwork for later, large-scale clinical investigations into the potential of estrogen-based menopausal hormone therapies for the prevention of a variety of age-related disorders. Although findings of these studies were equivocal, the neuroprotective actions of estrogen, and specifically 17β-estradiol, identified by early investigations, remain well-documented. Future development of interventions that optimize cognitive aging are crucial and, with proper understanding of the factors that influence the realization of beneficial impacts, estrogen-containing treatments may still be

  18. Establishing cellular stress response profiles as biomarkers of homeodynamics, health, and hormesis

    DEFF Research Database (Denmark)

    Demirovic, Dino; Rattan, Suresh


    Aging is the progressive shrinkage of the homeodynamic space. A crucial component of the homeodynamic space is the stress response (SR), by virtue of which a living system senses disturbance and initiates a series of events for maintenance, repair, adaptation, remodeling and survival. Here we...... and the health status of cells and organisms. SRP can also be useful for testing potential protectors and stimulators of homeodynamics, and can be a standard for monitoring the efficacy of potential pro-survival, health-promoting and aging-modulating conditions, food components and other compounds. An effective...... strategy, which makes use of SRP for achieving healthy aging and extending the healthspan, is that of strengthening the homeodynamics through repeated mild stress-induced hormesis by physical, biological and nutritional hormetins. Furthermore, SRP can also be the basis for defining health as a state...

  19. The ecological stress theory of aging and hormesis: an energetic evolutionary model. (United States)

    Parsons, Peter A


    Free-living organisms normally struggle to exist in harsh environments that are nutritionally and energetically inadequate, where evolutionary adaptation is challenged by internal stresses within organisms and external stresses from the environment. The incorporation of environmental variables into aging theories such as the free-radical and metabolic rate/oxidative stress theories, is the basis of the ecological stress theory of aging and hormesis. Environmental variation from optimum to lethal extremes gives a fitness-stress continuum, where energetic efficiency, or fitness, is inversely related to stress level; in the evolutionary context survival is a more direct measure of fitness for assessing aging than is lifespan. On this continuum, the hormetic zone is in the optimum region, while aging emphasizes survival towards lethal extremes. At the limits of survival, a convergence of physiological and genetical processes is expected under accumulating stress from Reactive Oxygen Species, ROS. Limited ecologically-oriented studies imply that major genes are important towards limits of survival compared with the hormetic zone. Future investigations could usefully explore outlier populations physiologically and genetically, since there is the likelihood that genetic variability may be lower in those cohorts managing to survive to extremely advanced ages as found in highly stressed ecological outlier populations. If so, an evolutionary explanation of the mortality-rate decline typical of cohorts of the extremely old emerges. In summary, an energetic evolutionary approach produces a general aging theory which automatically incorporates hormesis, since the theory is based on a fitness-stress continuum covering the whole range of possible abiotic environments of natural populations.

  20. Historical consciousness - Contemporary history and the problem of historical perception

    NARCIS (Netherlands)

    Den Hollander, JC


    Historical consciousness is an elusive concept, as long as we try to understand it from the narrow perspective of professional historians. Therefore, a wider perspective is needed. If we accept that historical understanding has become a general trait of modern culture, we may try to explain it in te

  1. History of Science in the Science Curriculum: An Historical Perspective. Part I: Early Interest and Roles Advocated. (United States)

    Sherratt, W. J.


    Discusses some of the factors underlying early calls for history of science in the science curriculum of English secondary schools. These factors focus on attacks on science, disquiet among science teachers, and parallelism between intellectual and historical development. Also discusses roles seen for historial materials advocated up to World War…

  2. Human Capital or Humane Talent? Rethinking the Nature of Education in China from a Comparative Historical Perspective (United States)

    Bai, Limin


    In order to analyze the impact of human capital theory on contemporary Chinese education, this paper first draws a conceptual outline of how this theory was introduced and interpreted to suit the Chinese quest for modernization. The study then adopts a comparative historical approach to the points of similarity between Neo-Confucian educational…

  3. Video "Reading" and Multimodality: A Study of ESL/Literacy Pupils' Interpretation of "Cinderella" from Their Socio-Historical Perspective (United States)

    Ajayi, Lasisi


    The purpose of this study was to investigate how Hispanic ESL/literacy learners used their socio-historical experiences and multimodal resources to mediate interpretation and representation of "Cinderella". Eighteen third-grade pupils "read" the video and re-created their understandings in pictures and sentences. The findings suggest that (a)…

  4. Health Administrator Perspectives on Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome Prevention and Services at Historically Black Colleges and Universities (United States)

    Warren-Jeanpiere, Lari; Jones, Sandra; Sutton, Madeline Y.


    Objective: Due to the disproportionate impact of human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) among African American young adults, the authors explored (1) number of historically black college and university (HBCU) campuses with existing HIV prevention policies and services and (2) perceived barriers for implementing…

  5. SafeCare: Historical Perspective and Dynamic Development of an Evidence-Based Scaled-Up Model for the Prevention of Child Maltreatment

    Directory of Open Access Journals (Sweden)

    Katelyn M. Guastaferro


    Full Text Available SafeCare is an evidence-based parent-training program that reduces child maltreatment, particularly neglect. The risk of child maltreatment, a public health issue affecting millions of U.S. children each year, can be markedly reduced by interventions such as SafeCare that deliver in-home services. Drawing from applied behavioral analysis roots, SafeCare focuses on providing parents with concrete skills in three areas: health, home safety, and parent-child/-infant interaction. This paper will include an overview of the SafeCare model, an historical perspective of its history and dynamic development, description of the theoretical underpinnings of the model, a description of the program targets and content by describing its modules and delivery, an overview of program outcomes, and data discussion of dissemination and implementation.

  6. Historical perspectives on the discovery and elucidation of autoantibodies to centromere proteins (CENP) and the emerging importance of antibodies to CENP-F. (United States)

    Fritzler, Marvin J; Rattner, Jerome B; Luft, LeeAnne M; Edworthy, Steven M; Casiano, Carlos A; Peebles, Carol; Mahler, Michael


    Autoantibodies to the centromere proteins (CENP), which are major constituents of the primary constriction of metaphase chromosomes, were first described in 1980. In those seminal publications and 30 years of research that have followed, a number of CENP have been identified as autoantibody targets in human diseases. Historically, autoantibodies directed to CENP-A, -B and -C have been considered relatively specific biomarkers for limited cutaneous systemic sclerosis (lcSSc) or the calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia (CREST) syndrome. These autoantibodies, found in up to 40% of SSc sera, can be identified by indirect immunofluorescence (IIF) on a variety of tissue culture cell lines as a discrete speckled staining pattern of both interphase nuclei and metaphase chromatin. Early in the investigation of anti-CENP, it became apparent that some autoantibodies had a similar IIF pattern wherein as cells entered into the cell cycle, speckled staining of the metaphase chromatin could be observed but, unlike conventional CENP staining, interphase nuclei were not stained. Subsequent studies identified one of the targets of these autoantibodies to be CENP-F, a kinesin binding protein essential for completion of the cell cycle. Early clinical studies found that, unlike antibodies to the earlier described CENP, lcSSc rarely expressed anti-CENP-F and approximately 50% of these patients had a malignancy. This review provides a historical perspective of CENP autoantibodies and focuses on an update of the information on CENP-F and their clinical associations.

  7. Radioactive waste storage: historical outlook and socio technical analysis; Le stockage des dechets radioactifs: perspective historique et analyse sociotechnique

    Energy Technology Data Exchange (ETDEWEB)

    Petit, J.C.


    The radioactive waste storage remains, in most of the industrialized concerned countries, one extremely debated question. This problem may, if an acceptable socially answer is not found, to create obstacles to the whole nuclear path. This study aim was to analyze the controversy in an historical outlook. The large technological plans have always economical, political, sociological, psychological and so on aspects, that the experts may be inclined to neglect. ``Escape of radioactivity is unlikely, as long as surveillance of the waste is maintained, that is, as long as someone is present to check for leaks or corrosion or malfunctioning of and to take action, if any of these occur. 444 refs., 32 figs.

  8. Photon hormesis deactivates alpha-particle induced bystander effects between zebrafish embryos (United States)

    Ng, C. Y. P.; Cheng, S. H.; Yu, K. N.


    In the present work, we studied the effects of low-dose X-ray photons on the alpha-particle induced bystander effects between embryos of the zebrafish, Danio rerio. The effects on the naive whole embryos were studied through quantification of apoptotic signals (amounts of cells undergoing apoptosis) at 24 h post fertilization (hpf) using vital dye acridine orange staining, followed by counting the stained cells under a fluorescent microscope. We report data showing that embryos at 5 hpf subjected to a 4.4 mGy alpha-particle irradiation could release a stress signal into the medium, which could induce bystander effect in partnered naive embryos sharing the same medium. We also report that the bystander effect was deactivated when the irradiated embryos were subjected to a concomitant irradiation of 10 or 14 mGy of X-rays, but no such deactivation was achieved if the concomitant X-ray dose dropped to 2.5 or 5 mGy. In the present study, the significant drop in the amount of apoptotic signals on the embryos having received 4.4 mGy alpha particles together X-rays irradiation from 2.5 or 5 mGy to 10 or 14 mGy, together with the deactivation of RIBE with concomitant irradiation of 10 or 14 mGy of X-rays supported the participation of photon hormesis with an onset dose between 5 and 10 mGy, which might lead to removal of aberrant cells through early apoptosis or induction of high-fidelity DNA repair. As we found that photons and alpha particles could have opposite biological effects when these were simultaneously irradiated onto living organisms, these ionizing radiations could be viewed as two different environmental stressors, and the resultant effects could be regarded as multiple stressor effects. The present work presented the first study on a multiple stressor effect which occurred on bystander organisms. In other words, this was a non-targeted multiple stressor effect. The photon hormesis could also explain some failed attempts to observe neutron-induced bystander

  9. Hormesis and its application in medicinal plant growing%Hormesis及其在药用植物生产中的应用

    Institute of Scientific and Technical Information of China (English)

    郭兰萍; 张小波; 杨光; 黄璐琦; 马炯


    Hormesis describes the low-dose stimulation and high-dose inhibition phenomena for all kind lives under toxicity environment.This paper generalized hormesis of medicinal plant on grow and metabolite after introducing the concept and study state of hormesis and analyzing hormesis mechanism and its significance.It points out that hormesis can be well used for medicinal plants growth, including increasing the metabolise, giving a dereaction for cultivated field chosen, guiding the agriculture management during the cultivation and improving the anti-stres.%"Honnesis"是指生物体在不同剂量化学物质刺激下产生的,以双相剂量--反应曲线为特征的一种适应性反应.作者在分析了Hormesis概念、机制、研究现状及生物学意义的基础上,总结了药用植物生长发育及次生代谢产物积累的Hortnesis现象,指出了Hormesis在药用植物生产中的应用,包括提高次生代谢产物,指导中药材适生地的选择,指导中药材生产管理,提高植物整体抗逆性.

  10. Art, production and market conditions: Gottfried Semper’s historical perspective on commodities and the role of museums

    Directory of Open Access Journals (Sweden)

    Claudio Leoni


    Full Text Available This paper looks at Gottfried Semper’s notions on the commodity and capitalism. When Semper attended the Great Exhibition, he realized the enormous impact that capitalist industries and interests have had on the arts. The Crystal Palace has always been at the centre of Semper scholarship but the focus has been less on capitalism than on the arts and crafts although Semper’s comments on capitalism are apparent and illustrate that he understood that everything becomes a commodity, even architecture. As a theorist trying to principles of by which art is driven, he analyzes industries and their mass produced objects and tries to come to terms with this. At the same time, he tries to integrate capitalism into his historical and scientific models. This paper tries to unravel Semper’s ideas on capitalism and the way he tries to resolve its problems in artistic production.

  11. The negative impact of the cognitive movement on the continued growth of the behavior therapy movement: a historical perspective. (United States)

    Levis, D J


    In recent years, a growing number of behavior therapists have expressed concern over the current state of the behavioral therapy movement. Some of the major problems raised center on current overload and fractionization, the lack of a coherent overall picture, the loss of identity, and the influx of cognitivism. In an attempt to enhance understanding of the factors responsible for the current crises in the behavior therapy field, the author provides a historical overview of the behavioral movement from its original conception to its current state. An argument is made that the solution to the afore-mentioned problems resides in the readoption of the underlying philosophy of science that originally gave birth and purpose to the field.

  12. Aviation Medicine: global historical perspectives and the development of Aviation Medicine alongside the growth of Singapore's aviation landscape. (United States)

    Gan, W H; Low, R; Singh, J


    Aviation Medicine traces its roots to high altitude physiology more than 400 years ago. Since then, great strides have been made in this medical specialty, initially catalysed by the need to reduce pilot medical attrition during the World Wars, and more recently, fuelled by the explosive growth in globalised commercial air travel. This paper traces the historical milestones in Aviation Medicine, and maps its development in Singapore since the 1960s. Advancements in military aviation platforms and technology as well as the establishment of Singapore as an international aviation hub have propelled Aviation Medicine in Singapore to the forefront of many domains. These span Aviation Physiology training, selection medical standards, performance maximisation, as well as crew and passenger protection against communicable diseases arising from air travel. The year 2011 marks the centennial milestone of the first manned flight in Singapore, paving the way for further growth of Aviation Medicine as a mature specialty in Singapore.

  13. Historical and Physical Account on Entropy and Perspectives on the Second Law of Thermodynamics for Astrophysical and Cosmological Systems

    Directory of Open Access Journals (Sweden)

    Jeroen Schoenmaker


    Full Text Available We performed an in depth analysis of the subjects of entropy and the second law of thermodynamics and how they are treated in astrophysical systems. These subjects are retraced historically from the early works on thermodynamics to the modern statistical mechanical approach and analyzed in view of specific practices within the field of astrophysics. As often happens in discussions regarding cosmology, the implications of this analysis range from physics to philosophy of science. We argue that the difficult question regarding entropy and the second law in the scope of cosmology is a consequence of the dominating paradigm. We further demonstrate this point by assuming an alternative paradigm, not related to thermodynamics of horizons, and successfully describing entropic behavior of astrophysical systems.

  14. The hormesis effect of plasma-elevated intracellular ROS on HaCaT cells (United States)

    Szili, Endre J.; Harding, Frances J.; Hong, Sung-Ha; Herrmann, Franziska; Voelcker, Nicolas H.; Short, Robert D.


    We have examined the link between ionized-gas plasma delivery of reactive oxygen species (ROS) to immortalized keratinocyte (HaCaT) cells and cell fate, defined in terms of cell viability versus death. Phospholipid vesicles were used as cell mimics to measure the possible intracellular ROS concentration, [ROSi], delivered by various plasma treatments. Cells were exposed to a helium cold atmospheric plasma (CAP) jet for different plasma exposure times (5-60 s) and gas flow rates (50-1000 ml min-1). Based upon the [ROSi] data we argue that plasma-generated ROS in the cell culture medium can readily diffuse into real cells. Plasma exposure that equated to an [ROSi] in the range of 3.81  ×  10-10-9.47  ×  10-8 M, measured at 1 h after the plasma exposure, resulted in increased cell viability at 72 h; whereas a higher [ROSi] at 1 h decreased cell viability after 72 h of culture. This may be because of the manner in which the ROS are delivered by the plasma: HaCaT cells better tolerate a low ROS flux over an extended plasma exposure period of 1 min, compared to a high flux delivered in a few seconds, although the final [ROSi] may be the same. Our results suggest that plasma stimulation of HaCaT cells follows the principle of hormesis.

  15. Interpreting 'dose-response' curves using homeodynamic data: with an improved explanation for hormesis. (United States)

    Stebbing, A R D


    A re-interpretation of the 'dose-response' curve is given that accommodates homeostasis. The outcome, or overall effect, of toxicity is the consequence of toxicity that is moderated by homeodynamic responses. Equilibrium is achieved by a balance of opposing forces of toxic inhibition countered by a stimulatory response. A graphical model is given consisting of two linked curves (response vs concentration and effect vs concentration), which provide the basis for a re-interpretation of the 'dose-response' curve. The model indicates that such relationships are non-linear with a threshold, which is due to homeodynamic responses. Subthreshold concentrations in 'dose-response' curves provide the sum of toxic inhibition minus the homeodynamic response; the response itself is unseen in serving its purpose of neutralizing perturbation. This interpretation suggests why the alpha- and beta-curves are non-linear. The beta-curve indicates adaptive overcorrection to toxicity that confers greater resistance to subsequent toxic exposure, with hormesis as an epiphenomenon.

  16. Pest insect olfaction in an insecticide-contaminated environment : info-disruption or hormesis effect

    Directory of Open Access Journals (Sweden)

    Hélène eTricoire-Leignel


    Full Text Available Most animals, including pest insects, live in an odour world and depend strongly on chemical stimuli to get information on their biotic and abiotic environment. Although integrated pest management strategies including the use of insect growth regulators (IGRs are increasingly developed, most insect pest treatments rely on neurotoxic chemicals. These molecules are known to disrupt synaptic transmission, affecting therefore sensory systems. The wide-spread use of neurotoxic insecticides and the growing use of IGRs result in residual accumulation of low concentrations in the environment. These insecticide residues could act as an info-disruptor by modifying the chemical communication system, and therefore decrease chances of reproduction in target insects. However, residues can also induce a non-expected hormesis effect by enhancing reproduction abilities. Low insecticide doses might thus induce adaptive processes in the olfactory pathway of target insects, favouring the development of resistance. The effect of sublethal doses of insecticides has mainly been studied in beneficial insects such as honeybees. We review here what is known on the effects of sublethal doses of insecticides on the olfactory system of insect pests.

  17. Cell mechanics and stress: from molecular details to the 'universal cell reaction' and hormesis. (United States)

    Agutter, Paul S


    The 'universal cell reaction' (UCR), a coordinated biphasic response to external (noxious and other) stimuli observed in all living cells, was described by Nasonov and his colleagues in the mid-20th century. This work has received no attention from cell biologists in the West, but the UCR merits serious consideration. Although it is non-specific, it is likely to be underpinned by precise mechanisms and, if these mechanisms were characterized and their relationship to the UCR elucidated, then our understanding of the integration of cellular function could be improved. As a step towards identifying such mechanisms, I review some recent advances in understanding cell mechanics and the stress response and I suggest potentially testable hypotheses. There is a particular need for time-course studies of cellular responses to different stimulus doses or intensities. I also suggest a correspondence with hormesis; re-investigation of the UCR using modern biophysical and molecular-biological techniques might throw light on this much-discussed phenomenon.

  18. Nuclear energy and health: and the benefits of low-dose radiation hormesis. (United States)

    Cuttler, Jerry M; Pollycove, Myron


    Energy needs worldwide are expected to increase for the foreseeable future, but fuel supplies are limited. Nuclear reactors could supply much of the energy demand in a safe, sustainable manner were it not for fear of potential releases of radioactivity. Such releases would likely deliver a low dose or dose rate of radiation, within the range of naturally occurring radiation, to which life is already accustomed. The key areas of concern are discussed. Studies of actual health effects, especially thyroid cancers, following exposures are assessed. Radiation hormesis is explained, pointing out that beneficial effects are expected following a low dose or dose rate because protective responses against stresses are stimulated. The notions that no amount of radiation is small enough to be harmless and that a nuclear accident could kill hundreds of thousands are challenged in light of experience: more than a century with radiation and six decades with reactors. If nuclear energy is to play a significant role in meeting future needs, regulatory authorities must examine the scientific evidence and communicate the real health effects of nuclear radiation. Negative images and implications of health risks derived by unscientific extrapolations of harmful effects of high doses must be dispelled.

  19. Establishing cellular stress response profiles as biomarkers of homeodynamics, health and hormesis. (United States)

    Demirovic, Dino; Rattan, Suresh I S


    Aging is the progressive shrinkage of the homeodynamic space. A crucial component of the homeodynamic space is the stress response (SR), by virtue of which a living system senses disturbance and initiates a series of events for maintenance, repair, adaptation, remodeling and survival. Here we discuss the main intracellular SR pathways in human cells, and argue for the need to define and establish the immediate and delayed stress response profiles (SRP) during aging. Such SRP are required to be established at several age-points, which can be the molecular biomarkers of homeodynamic space and the health status of cells and organisms. SRP can also be useful for testing potential protectors and stimulators of homeodynamics, and can be a standard for monitoring the efficacy of potential pro-survival, health-promoting and aging-modulating conditions, food components and other compounds. An effective strategy, which makes use of SRP for achieving healthy aging and extending the healthspan, is that of strengthening the homeodynamics through repeated mild stress-induced hormesis by physical, biological and nutritional hormetins. Furthermore, SRP can also be the basis for defining health as a state of having adequate physical and mental independence of activities of daily living, by identifying a set of measurable parameters at the most fundamental level of biological organization.

  20. Historical perspective and modern applications of Attenuated Total Reflectance-Fourier Transform Infrared Spectroscopy (ATR-FTIR). (United States)

    Blum, Marc-Michael; John, Harald


    Vibrational spectroscopy has a long history as an important spectroscopic method in chemical and pharmaceutical analysis. Instrumentation for infrared (IR) spectroscopy was revolutionized by the introduction of Fourier Transform Infrared (FTIR) spectrometers. In addition, easier sampling combined with better sample-to-sample reproducibility and user-to-user spectral variation became available with attenuated total reflectance (ATR) probes and their application for in situ IR spectroscopy. These innovations allow many new applications in chemical and pharmaceutical analysis, such as the use of IR spectroscopy in Process Analytical Chemistry (PAC), the quantitation of drugs in complex matrix formulations, the analysis of protein binding and function and in combination with IR microscopy to the emergence of IR imaging technologies. The use of ATR-FTIR instruments in forensics and first response to 'white powder' incidents is also discussed. A short overview is given in this perspective article with the aim to renew and intensify interest in IR spectroscopy.

  1. A cultural historical activity theory perspective to understand preservice science teachers' reflections on and tensions during a microteaching experience (United States)

    Sezen-Barrie, Asli; Tran, Minh-Dan; McDonald, Scott P.; Kelly, Gregory J.


    This study draws from cultural historical activity theory (CHAT) to analyze preservice teachers' reflections on a microteaching activity. Microteaching activities involved preservice educators teaching middle school students from local schools. The study was conducted with 23 preservice teachers enrolled in a large university's teacher education program. During this secondary science teaching methods course, every pair of preservice teachers engaged in 20 minute microteaching activity with 3-5 middle school students. The microteaching was videotaped, and the teachers subsequently provided voice-over reflections on a second audio track. Transcriptions of the microteaching events were analyzed through the formation of event maps showing the phases of activity and the organizational sequence of actions. Event maps were used to investigate the focus of preservice teachers' reflections. The results showed that while learning from their microteaching, preservice teachers focused primarily on the mediating artifacts and gave least attention to the larger teaching community surrounding these activities. Use of CHAT helped to identify challenges in different elements of the microteaching activity. The study contributes to how reflective practice can be enhanced through attention to the social and cultural dimensions of the teaching.

  2. Science at Harvard University: Historical Perspectives, edited by Clark A. Elliott and Margaret W. Rossiter. Lehigh University Press, Bethlehem, 1992

    Directory of Open Access Journals (Sweden)

    Andrew L. Christenson


    Full Text Available This volume contains historical studies of several sciences as practiced at Harvard University. Two of these studies have relevance to the history of archaeology. A chapter by Toby Appel focuses upon the scientific career of Jeffries Wyman, first curator of Harvard's Peabody Museum. She contrasts Wyman's unassuming character with the dominating personality of his mentor and contemporary Louis Agassiz. Trained as a medical doctor, Wyman's main love was zoology, particularly comparative anatomy. In his mid-40s, he encountered his first shell midden and was bitten by the archaeology bug. Soon he was doing pioneering excavation in both New England and Florida. In 1866, he was selected to be the curator of the Peabody Museum, primarily upon his strong museum background but also because of the high regard with which he was held by certain influential people. His selection to this position may have made him America's first professional archaeologist. His principal responsibilities were to collect and display archaeological and ethnological specimens and he made great steps in this direction prior to his death in 1874. Wyman's scientific work was poorly known or studied (he is best noted for having made the first scientific description of the gorilla, in part, Appel argues, because he did not seek acclaim or controversy. His greatest influence was locally through personal interactions with students and colleagues. His archaeological work is only briefly discussed in this and the following article, and there is still much to be written about this man of high character.

  3. Equipoise in Research and the Development of Neonatal Interventions for the Management of Respiratory Distress Syndrome: A Historical Perspective. (United States)

    Rojas, Mario Augusto


    The historical review of how evidence was developed for the management of respiratory distress syndrome in premature infants has not been clearly characterized. Knowledge of this process is essential to understand the role of equipoise and its influence on the decision to evaluate interventions as they were implemented in the practice of medicine. We suspect that errant approaches to clinical equipoise secondary to states of false certainty and false uncertainty have been important barriers to the timely acquisition and implementation of evidence-based knowledge necessary to improve outcomes in this fragile population of infants. When confronted with the decision to test an intervention, physicians should question whether they have lost clinical equipoise based on opinion, expertise, or observational data rather than evidence obtained from methodological inquiry; doing so facilitates reaching clinical equipoise and promotes the application of scientific methodology to answer relevant clinical questions. Timely acquisition of evidence-based knowledge can be viewed as an ethical imperative when the status quo may have negative consequences on outcomes for generations.

  4. The Objective Structured Clinical Examination (OSCE): AMEE Guide No. 81. Part I: an historical and theoretical perspective. (United States)

    Khan, Kamran Z; Ramachandran, Sankaranarayanan; Gaunt, Kathryn; Pushkar, Piyush


    The Objective Structured Clinical Examination (OSCE) was first described by Harden in 1975 as an alternative to the existing methods of assessing clinical performance (Harden et al. 1975). The OSCE was designed to improve the validity and reliability of assessment of performance, which was previously assessed using the long case and short case examinations. Since then the use of the OSCE has become widespread within both undergraduate and postgraduate clinical education. We recognise that the introduction of the OSCE into an existing assessment programme is a challenging process requiring a considerable amount of theoretical and practical knowledge. The two parts of this Guide are designed to assist all those who intend implementing the OSCE into their assessment systems. Part I addresses the theoretical aspects of the OSCE, exploring its historical development, its place within the range of assessment tools and its core applications. Part II offers more practical information on the process of implementing an OSCE, including guidance on developing OSCE stations, choosing scoring rubrics, training examiners and standardised patients and managing quality assurance processes. Together we hope these two parts will act as a useful resource both for those choosing to implement the OSCE for the first time and also those wishing to quality assure their existing OSCE programme.

  5. Perspectives (United States)

    Tarone, Elaine


    The topic of this "Perspectives" column is "Requiring a Proficiency Level as a Requirement for U.S. K-12 Teacher Licensure." In 1998, the American Council of Teachers of Foreign Languages (ACTFL) began to work with the National Council for Accreditation of Teacher Education (NCATE), which accredits teacher education programs…

  6. 浅谈饶宗颐的文化历史观%A Brief Discussion of Jao Tsung-I’s Cultural-historical Perspective

    Institute of Scientific and Technical Information of China (English)



    This paper discusses some views and assertions of Chinese culture by Jao Tsung-I, dubbed by many as“Dongzhou Hongru”(the erudite scholar of the East) and“Guoxue Dashi”(the master of Chinese culture), through the angles of“multicultural and historical perspective”and“time-spatial cultural-histori-cal perspective”respectively. Jao Tsung-I’s scholarship puts an emphasis on“Tri-fold Evidence Methodol-ogy”, namely field archaeology, historical records and oracle bone scripts. He on the one hand uses Chinese exegetics to trace the origin, applying philology to the study of culture and history, while on the other hand ac-quires a keen insight into a comprehensive view of the situation from bibliography. The attainment of being a great learned literate results in Jao’s time-spatial cultural-historical perspective with a convergence of the an-cient and the modernized. The academic achievements of Jao contribute to important inspiration and valuable cultural heritage for future scholars.%  从“多元文化历史观”和“时空兼顾的文化历史观”两方面来看“东洲鸿儒”、“国学大师”饶宗颐对中国文化的看法和主张,饶宗颐治学強调“三重证据法”即田野考古、文献记录和甲骨文三方面的资料,一方面用中国训诂学的方法去溯本追源,把语言文字学运用到文化史的研究中去,一方面从目录学上得到通观全局的眼力。这种“通儒”境界,造就了饶宗颐“博古通今,中西贯通”时空兼顾的文化历史观。饶宗颐的学术成果为以后的学者留下了重要的启示与宝贵的文化遗产。

  7. The Synthetic Elicitor 2-(5-Bromo-2-Hydroxy-Phenyl)-Thiazolidine-4-Carboxylic Acid Links Plant Immunity to Hormesis. (United States)

    Rodriguez-Salus, Melinda; Bektas, Yasemin; Schroeder, Mercedes; Knoth, Colleen; Vu, Trang; Roberts, Philip; Kaloshian, Isgouhi; Eulgem, Thomas


    Synthetic elicitors are drug-like compounds that induce plant immune responses but are structurally distinct from natural defense elicitors. Using high-throughput screening, we previously identified 114 synthetic elicitors that activate the expression of a pathogen-responsive reporter gene in Arabidopsis (Arabidopsis thaliana). Here, we report on the characterization of one of these compounds, 2-(5-bromo-2-hydroxy-phenyl)-thiazolidine-4-carboxylic acid (BHTC). BHTC induces disease resistance of plants against bacterial, oomycete, and fungal pathogens and has a unique mode of action and structure. Surprisingly, we found that low doses of BHTC enhanced root growth in Arabidopsis, while high doses of this compound inhibited root growth, besides inducing defense. These effects are reminiscent of the hormetic response, which is characterized by low-dose stimulatory effects of a wide range of agents that are toxic or inhibitory at higher doses. Like its effects on defense, BHTC-induced hormesis in Arabidopsis roots is partially dependent on the WRKY70 transcription factor. Interestingly, BHTC-induced root hormesis is also affected in the auxin-response mutants axr1-3 and slr-1. By messenger RNA sequencing, we uncovered a dramatic difference between transcriptional profiles triggered by low and high doses of BHTC. Only high levels of BHTC induce typical defense-related transcriptional changes. Instead, low BHTC levels trigger a coordinated intercompartmental transcriptional response manifested in the suppression of photosynthesis- and respiration-related genes in the nucleus, chloroplasts, and mitochondria as well as the induction of development-related nuclear genes. Taken together, our functional characterization of BHTC links defense regulation to hormesis and provides a hypothetical transcriptional scenario for the induction of hormetic root growth.

  8. Formulation of work stress in 1960-2000: analysis of scientific works from the perspective of historical sociology. (United States)

    Väänänen, Ari; Anttila, Erkko; Turtiainen, Jussi; Varje, Pekka


    During the latter part of the 20th century, work stress became an important societal issue and a huge amount of scientific attention went to studying it. This paper examines the process of formulating and defining the concept of work stress in the occupational health sciences and in industrial and organizational psychology from the early 1960s to the late 1990s. The empirical material of the study encompasses 108 scientific articles, books, book chapters, 'state of the art' reviews, book reviews, and written conference presentations. The data are analysed in the frameworks of historical sociology, critical psychology, and the anthropology of knowledge. We argue that work stress as a life-structuring concept gained ground in psychosocial and occupational health sciences (and also in lay understanding) in the 1960s simultaneously with the rise of social reformist movements that called for fundamental changes emphasizing democratic and human-orientated work organizations and socially responsible values. With the passing of time, however, the focus on structural improvement of work life waned and the emphasis shifted towards the apolitical occupational health aspects of work stress. Researchers with a psychological orientation emphasized micro-level characteristics as factors affecting work stress, whereas stress-orientated epidemiologists turned to the study of specific occupational stress models and/or risk factors. The emergence and development of work stress research can be seen as a chain of attempts to define and identify new risks and experiences occurring in work life. The process, driven by a gradual shift from industrial environments towards organizational frameworks characterized by social and psychological dimensions, reflected the overall shift towards modern democratic work life and the information society in which employees' emotions and well-being became an issue.

  9. Globalisations in a nutshell: Historical perspectives on the changing governance of the shea commodity chain in northern Ghana

    Directory of Open Access Journals (Sweden)

    Andrew Wardell


    Full Text Available Pre-colonial patterns of trade in West Africa included exchanges of shea in periodic local and regional markets. The collection, processing and marketing of shea products in such markets continues to be predominantly by women to both meet subsistence needs, and exchange of surpluses. In the early part of the 20th century, the British colonial administration considered the possibilities of starting large-scale exports of shea kernels to Europe. Multiple colonial initiatives to develop the global trade were not successful due to a composite of factors. Contemporary patterns of production, trade and regulation are contrasted in the context of globalisation in the post-independence era. The government of Ghana has progressively reinforced its ambitions to expand the shea nut trade as part of the state’s portfolio of major non-traditional agricultural export commodities. This policy is embedded within the (now dominant orthodoxy of neo-liberalism, which privileges monetized production systems and private over public regulation. Historically and culturally-embedded patterns of shea production and trade by women in northern Ghana may now be challenged by the emergence of new processing technologies, the emergence of an oligopolistic global commodity chain and the anticipated continued growth in global demand for cocoa butter equivalents.  Nevertheless, the cumulative impacts of increasing commercialisation and world market integration at the national and local level in Ghana, and other West African producer countries, are still unknown. There are risks, however, that this process may result in social differentiation, changes in household consumption patterns and loss of livelihoods, particularly for women.

  10. Toward an epistemology of nano-technosciences: Probing technoscience from a historical perspective: on today's surprising prevalence and relevance of Francis Bacon. (United States)

    Schmidt, Jan C


    This paper aims to contribute to the attempts to clarify and classify the vague notion of "technosciences" from a historical perspective. A key question that is raised is as follows: Does Francis Bacon, one of the founding fathers of the modern age, provide a hitherto largely undiscovered programmatic position, which might facilitate a more profound understanding of technosciences? The paper argues that nearly everything we need today for an ontologically well-informed epistemology of technoscience can be found in the works of Bacon-this position will be called epistemological real-constructivism. Rather than realist or constructivist, empiricist or rationalist, Bacon's position can best be understood as real-constructivist since it challenges modern dichotomies. Reflection upon the contemporary relevance of Bacon could contribute to the expanding and critical discussion on technoscience. In the following I will reconstruct the term "technoscience". My finding is that at least four different understandings or types of the term "technoscience" co-exist. In a second step, I will analyze and elaborate on Bacon's epistemological position. I will identify central elements of the four different understandings in Bacon's work. Finally, I will conclude that the epistemology of technoscience is, indeed, very old-it is the epistemological position put forward by Bacon.

  11. On the Historical and Cultural Elements Implied in The Last of the Mohi-cans from the Perspective of Cross-Cultural Communication

    Institute of Scientific and Technical Information of China (English)



    The last of the Mohicans was written by American novelist James Fenimore Cooper in 1826, who is considered as the first long novelist of America. The work has no concentrate plots but the white people and the Indians ’friendship, communica⁃tion, and wars.The Last of the Mohicans was set in the mid-18th century when the French colonists and English colonists were fighting for Indian lands. English colonized America and were at loggerheads with France. It belongs to the frontier literature and creates a precedent for the American Frontier Fiction. The American western fiction has the most native feature.With the rise of multiculturalism trend at present,it is the best way for understanding the American local culture and history to study the American western fiction which is bred during the course of the frontier-running and Westward Movement.Cooper is a novelist who de⁃picted the real and pure American life. Based on the frontier theme, he created Leatherstocking Tales, which is a series of five nov⁃els, are his masterpieces representing his style. Among them, The Last of the Mohicans prominently reflects the Indian culture.This thesis mainly explores the historical and cultural elements embodied in The Last of the Mohicans from the perspective of cross-cul⁃tural communication.

  12. An Analysis on Academic Misconduct in Perspective of Historical Institutionalism%历史制度主义视角下的学术不端分析

    Institute of Scientific and Technical Information of China (English)



    近年来,学术不端行为时有发生,引发了社会对这一问题的关注。从历史制度主义视角观察,我国缺乏对学术不端行为清晰的识别制度,科学的学术评价制度,有力的惩罚机制。由于制度的路径依赖,学术不端的治理呈现无效率的状态。为此,欲有效治理学术不端行为,应建立治理学术不端行为的行政法律制度,建立科学合理的学术考核机制,改革科研管理制度。%In recent years, academic misconducts occur every now and then, which have attracted much social attention. In a perspective of historical institutionalism, there lack clear identification systems, scientific evaluation systems and forceful punishment systems for academic misconducts in China. Due to path dependence of systems, the governance for academic misconducts is still inefficient. Thus some administrative legal systems for controlling academic misconducts, scientific academic evaluation systems should be timely established, while the scientific research system is reformed, so as to effectively wipe out the academic misconducts.

  13. Historizing epistemology in psychology. (United States)

    Jovanović, Gordana


    The conflict between the psychometric methodological framework and the particularities of human experiences reported in psychotherapeutic context led Michael Schwarz to raise the question whether psychology is based on a methodological error. I take this conflict as a heuristic tool for the reconstruction of the early history of psychology, which bears witness to similar epistemological conflicts, though the dominant historiography of psychology has largely forgotten alternative conceptions and their valuable insights into complexities of psychic phenomena. In order to work against the historical amnesia in psychology I suggest to look at cultural-historical contexts which decisively shaped epistemological choices in psychology. Instead of keeping epistemology and history of psychology separate, which nurtures individualism and naturalism in psychology, I argue for historizing epistemology and for historical psychology. From such a historically reflected perspective psychology in contemporary world can be approached more critically.

  14. Non-linear uptake and hormesis effects of selenium in red-winged blackbirds (Agelaius phoeniceus). (United States)

    Harding, Lee E


    Effects of selenium on reproductive success were assessed in red-winged blackbirds (Agelaius phoeniceus). Mean egg selenium (MES) ranged from 2.96 to 21.7 mg/kg dry weight with individual eggs up to 40 mg/kg. Uptake was non-linear: increments in MES declined as aqueous selenium increased; the asymptote was approximately 23 mg/kg. Eggs were heavier and more were laid in 2004 compared to 2005, a year of record rainfall and below-normal temperatures. Mortality of embryos that were incubated to full term was low (2.6% in 2004 and 3.2% in 2005), as was the prevalence of embryonic defects (2.7% in 2004 and 5.1% in 2005). Abnormalities in nestlings were also rare. Egg mortality was caused by predation, weather, and parental abandonment. Nestlings died from predation, starvation, and hypothermia associated with rain and cold, drowning, and bacterial infections. Nestling liver concentrations reached 81 mg/kg dry wt. selenium and were highest at the most highly selenium-exposed sites. Blood glutathione peroxidase (a selenium-dependent enzyme indicative of selenium exposure) was unrelated to liver selenium concentrations, egg selenium, or ambient selenium exposure. The selenium concentration in prey that parents fed to nestlings was higher at the selenium-exposed sites (up to 37 mg/kg dry wt. Se) compared to reference sites. Aqueous selenate:selenite ratios were related to redox differences and were much higher at the site with the highest MES, liver selenium, and prey item selenium concentrations. Hatchability showed U-shaped, or hormesis, relationships with MES: productivity increased with selenium concentrations at low exposures and decreased at high exposures. The effects threshold was approximately 22 mg/kg dry wt. MES.

  15. 大学自治的意蕴:历史向度与现实向度%The Implication of University Autonomy: The Historical Perspective and the Realistic Perspective

    Institute of Scientific and Technical Information of China (English)

    钱志刚; 祝延


    University autonomy is the foundation for the existence and development of the university.Viewed from the historical perspective,university autonomy is a struggle guaranteeing the existence and development of the university;it is an inheritance protecting university philosophy and ideal from being overwhelmed;it is some equilibrium contributing to the compromise and compatibility between the university and other organizations.From the perspective of reality,university autonomy means the spirit of perseverance that keeps universities from getting lost in its pursuit of scientific truth;it means a kind of responsibility that ensures the persistent performance of public functions;it also means a certain guidance that brings about the constant transcendence of social reality.The revelation and demonstration of the implication of university autonomy is supposed to shed light on and grasp the historical trajectory and realistic implication of university autonomy,and to play a better role in guiding the construction and development of modern universities.%大学自治是大学生存发展的根基。从历史向度看,大学自治是一种斗争,使大学生存和发展得以保证;是一种传承,使大学理念和理想不被淹没;是一种平衡,使大学和其他组织妥协相容。从现实向度看,大学自治是一种守护,使大学不迷失对真理的追求;是一种责任,使大学不松懈对公共职能的履行;是一种引领,使大学不放弃对现实社会的超越。揭示和彰显大学自治意蕴,能更好地理解和把握大学自治的历史轨迹和现实内涵,更好地引导现代大学的建设与发展。

  16. Mobile phone signal exposure triggers a hormesis-like effect in Atm(+/+) and Atm(-/-) mouse embryonic fibroblasts. (United States)

    Sun, Chuan; Wei, Xiaoxia; Fei, Yue; Su, Liling; Zhao, Xinyuan; Chen, Guangdi; Xu, Zhengping


    Radiofrequency electromagnetic fields (RF-EMFs) have been classified by the International Agency for Research on Cancer as possible carcinogens to humans; however, this conclusion is based on limited epidemiological findings and lacks solid support from experimental studies. In particular, there are no consistent data regarding the genotoxicity of RF-EMFs. Ataxia telangiectasia mutated (ATM) is recognised as a chief guardian of genomic stability. To address the debate on whether RF-EMFs are genotoxic, we compared the effects of 1,800 MHz RF-EMF exposure on genomic DNA in mouse embryonic fibroblasts (MEFs) with proficient (Atm(+/+)) or deficient (Atm(-/-)) ATM. In Atm(+/+) MEFs, RF-EMF exposure for 1 h at an average special absorption rate of 4.0 W/kg induced significant DNA single-strand breaks (SSBs) and activated the SSB repair mechanism. This effect reduced the DNA damage to less than that of the background level after 36 hours of exposure. In the Atm(-/-) MEFs, the same RF-EMF exposure for 12 h induced both SSBs and double-strand breaks and activated the two repair processes, which also reduced the DNA damage to less than the control level after prolonged exposure. The observed phenomenon is similar to the hormesis of a toxic substance at a low dose. To the best of our knowledge, this study is the first to report a hormesis-like effect of an RF-EMF.

  17. Adaptation to acrolein through upregulating the protection by glutathione in human bronchial epithelial cells: the materialization of the hormesis concept. (United States)

    Sthijns, Mireille M J P E; Randall, Matthew J; Bast, Aalt; Haenen, Guido R M M


    Acrolein is a thiol reactive compound present in cigarette smoke and plays a pivotal role in the deleterious effects of smoking. Acrolein causes toxicity in human bronchial epithelial cells in a dose dependent manner. GSH forms the first line of defense against acrolein-induced toxicity. At high doses of acrolein (⩾10 μM) the capacity of the cellular protection by GSH is overwhelmed and GSH is not able to quench all the acrolein, resulting in cytotoxicity. At a relatively low dose of acrolein (3 μM), no cytotoxicity is observed due to protection by GSH. Moreover we found that exposure to a low dose of acrolein protects cells against the toxic effect of a second higher dose of acrolein. The adaptation to acrolein is induced via Nrf2 mediated gene expression of γ-glutamylcysteine synthetase leading to elevated GSH levels. This upregulation of the protection by GSH demonstrates a hormetic response to acrolein. Hormesis is an adaptive or compensatory response induced by a relatively subtle challenge of homeostasis by a toxic compound. Insight into the mechanism of hormesis is mandatory for a more accurate societal regulation of toxic compounds.

  18. Biphasic toxicodynamic features of some antimicrobial agents on microbial growth: a dynamic mathematical model and its implications on hormesis

    Directory of Open Access Journals (Sweden)

    Murado Miguel A


    Full Text Available Abstract Background In the present work, we describe a group of anomalous dose-response (DR profiles and develop a dynamic model that is able to explain them. Responses were obtained from conventional assays of three antimicrobial agents (nisin, pediocin and phenol against two microorganisms (Carnobacterium piscicola and Leuconostoc mesenteroides. Results Some of these anomalous profiles show biphasic trends which are usually attributed to hormetic responses. But they can also be explained as the result of the time-course of the response from a microbial population with a bimodal distribution of sensitivity to an effector, and there is evidence suggesting this last origin. In light of interest in the hormetic phenomenology and the possibility of confusing it with other phenomena, especially in the bioassay of complex materials we try to define some criteria which allow us to distinguish between sensu stricto hormesis and biphasic responses due to other causes. Finally, we discuss some problems concerning the metric of the dose in connection with the exposure time, and we make a cautionary suggestion about the use of bacteriocins as antimicrobial agents. Conclusions The mathematical model proposed, which combines the basis of DR theory with microbial growth kinetics, can generate and explain all types of anomalous experimental profiles. These profiles could also be described in a simpler way by means of bisigmoidal equations. Such equations could be successfully used in a microbiology and toxicology context to discriminate between hormesis and other biphasic phenomena.

  19. Perspective

    DEFF Research Database (Denmark)

    Kussmann, Martin; Morine, Melissa J; Hager, Jörg


    We review here the status of human type 2 diabetes studies from a genetic, epidemiological, and clinical (intervention) perspective. Most studies limit analyses to one or a few omic technologies providing data of components of physiological processes. Since all chronic diseases are multifactorial...... of the complexity of T2DM, we propose a systems biology approach to advance the understanding of origin, onset, development, prevention, and treatment of this complex disease. This systems-based strategy is based on new study design principles and the integrated application of omics technologies: we pursue...

  20. On ecological crisis from the perspective of historical materialism%论历史唯物主义视阈下的生态危机

    Institute of Scientific and Technical Information of China (English)

    陶火生; 薛帆帆


    随着社会的不断发展,生态问题逐渐演变成生态危机,人们开始重新审视和思考生态危机的出现与人类社会的生存、发展模式之间的联系。以历史唯物主义为切入点,通过剖析生产力、生产关系、生产方式、上层建筑与社会状况之间的关系,论证了资本主义的生产方式是生态危机出现的根源。在历史唯物主义的指导下,提出了以打破资本主义生产方式所遵循的逻辑为主,以合理运用科学技术、生态制度规范、改善意识形态等途径为辅,共同化解生态危机,构建和谐社会的途径。%As ecological problems have gradually evolved into ecological crises owing to the steady development of the society,people have begun to re-examine the relationship between the occurrence of the ecological crises and the survival and the development patterns of human and the society.The relationships among productivity,production relations,production mode,the superstructure and so-cial status are analysed in the perspective of historical materialism.It confirms that the capitalist mode of production is the root of the ecological crises.A proposal is proposed under the guidance of historical materialism that we should break the logic of the capitalist mode of production and combine the rational use of science and technology,ecological systems standardization and ideology improve-ment to resolve the ecological crises and to build a harmonious society.

  1. Psychiatry and political-institutional abuse from the historical perspective: the ethical lessons of the Nuremberg Trial on their 60th anniversary. (United States)

    López-Muñoz, Francisco; Alamo, Cecilio; Dudley, Michael; Rubio, Gabriel; García-García, Pilar; Molina, Juan D; Okasha, Ahmed


    Sixty years ago at the Nuremberg Trials, 23 Nazi leaders were tried as war criminals, in what was known as "The Doctors' Trial". This trial exposed a perverse system of the criminal use of medicine in the fields of public health and human research. These practices, in which racial hygiene constituted one of the fundamental principles and euthanasia programmes were the most obvious consequence, violated the majority of known bioethical principles. Psychiatry played a central role in these programmes, and the mentally ill were the principal victims. The aim of the present work is to review, from the historical perspective, the antecedents of the shameful euthanasia programmes for the mentally ill, the procedures involved in their implementation and the use of mentally ill people as research material. The Nuremberg Code, a direct consequence of the Doctors' Trial, is considered to be the first international code of ethics for research with human beings, and represented an attempt to prevent any repeat of the tragedy that occurred under Nazism. Nevertheless, the last 60 years have seen continued government-endorsed psychiatric abuse and illegitimate use of psychoactive drugs in countries such as the Soviet Union or China, and even in some with a long democratic tradition, such as the United States. Even today, the improper use of psychiatry on behalf of governments is seen to be occurring in numerous parts of the globe: religious repression in China, enforced hospitalization in Russia, administration of psychoactive drugs in immigrant detention centres in Australia, and the application of the death penalty by lethal injection and psychiatric participation in coercive interrogation at military prisons, in relation to the USA. The Declaration of Madrid in 1996 constituted the most recent attempt to eradicate, from the ethical point of view, these horrendous practices. Various strategies can be used to combat such abuses, though it is uncertain how effective they are in

  2. Some Problems in Constructing Moral Theory in Perspective of Historical Materialism%建构以唯物史观为视域的道德理论所面临的一些问题

    Institute of Scientific and Technical Information of China (English)

    翁学辉; 郑元叶


    马克思和恩格斯在《德意志意识形态》中比较全面地论述了他们的唯物史观。西方当代学者从不同角度对它提出了质疑。因此,要想构建唯物史观视域中的伦理或道德理论,有必要对这些质疑进行梳理。这些质疑包括把唯物史观看做是经济一元论或者一种历史决定论等,只有在合理反驳这些质疑的基础上,建构唯物史观的道德理论才是可能的。%Marx and Engels set forth the historical materialism in a more comprehensive way in the German Ideology .Contem-porary western scholars questioned and criticized it from different angles .Therefore ,in order to construct some ethical or mor-al point of view in the perspective of the historical materialism ,it is necessary to sort out the questioning and the criticizing points .The criticism includes one that it looks the historical materialism as an economic monism or a kind of historical deter-minism .It is possible to construct a moral theory in the perspective of the historical materialism only if we can refute them rea-sonably .

  3. Planet Classification: A Historical Perspective (United States)

    Weintraub, David A.


    As philosopher George Santayana famously said, "those who cannot remember the past are condemned to repeat it." The professional astronomy community, as embodied in the IAU, now suffers from Santayana's malady. Ceres was expelled from the community of planets because it apparently was not a planet; yet, no working, scientifically reasonable definition of the word planet existed in the early nineteenth century and so no rational basis existed for excluding or including Ceres or, for that matter, Uranus or the soon-to-be-discovered Neptune from the family of planets. Instead, William Herschel disparaged Ceres as only an "asteroid," a term he invented specifically to separate Ceres and Pallas and Vesta from the true planets. Clearly, in Herschel's view, Ceres was not big enough, and apparently, to Herschel, size mattered. So how big is big enough and by what method was size put in place as the critical scientific metric for assessing planethood? Certainly, as members of the newly discovered asteroid belt, the newly identified asteroids were members of a previously unknown family of objects in the solar system. But why did that make these non-classically known objects asteroids but not planets rather than asteroids and planets? Uranus and Neptune were also members of a newly identified and previously unknown family of solar system objects that we now call "ice giants." On what basis were these two objects embraced as planets and why have these two non-classical objects become known as ice giants and planets rather than ice giants but not planets? Perhaps our scientific predecessors were too quick to render judgment, as they lacked the scientific context in which to understand the many new objects discovered during the years 1781 to 1846. Is that a lesson from the past that we might remember today?

  4. Mastery Learning in Historical Perspective. (United States)

    Perko, F. Michael

    Seen in its strictest sense, mastery learning is a recent phenomenon. Viewed in terms of its constituent elements, however, it has roots deep in the Western tradition of education. Elements of mastery learning theory can be found in the work of the Sophists; early Jesuit educators; John Amos Comenius, a Moravian pastor; John Locke; Johann Heinrich…

  5. Schwarzschild Solution: A Historical Perspective (United States)

    Bartusiak, Marcia


    While eighteenth-century Newtonians had imagined a precursor to the black hole, the modern version has its roots in the first full solution to Einstein's equations of general relativity, derived by the German astronomer Karl Schwarzschild on a World War I battlefront just weeks after Einstein introduced his completed theory in November 1915. This talk will demonstrate how Schwarzschild's solution is linked to the black hole and how it took more than half a century for the physics community to accept that such a bizarre celestial object could exist in the universe.

  6. Historical perspectives on myelodysplastic syndromes. (United States)

    Steensma, David P


    Although Georg Hegel quipped, "We learn from history that we do not learn from history", Aldous Huxley expressed a more nuanced view: "The charm of history and its enigmatic lesson consist in the fact that, from age to age, nothing changes and yet everything is completely different." In order to understand present-day positions and peculiarities in any field of human endeavor, familiarity with the past is essential. Those of us who study myelodysplastic syndromes (MDS) or care for patients diagnosed with these troublesome conditions may wonder also how the current state of affairs evolved with respect to our narrow area of focus, and how we know what we think we know now about these still-enigmatic bone marrow diseases. Here, I review a number of developments that collectively represent a brief "history of MDS." I first highlight a few landmark observations that preceded any concept of MDS by hundreds of years. Twentieth-century case descriptions and series with hypotheses about the etiology and nature of disorders described as "refractory anemia", "preleukemia", and with other terminology culminated in the efforts of the French-American-British (FAB) Co-operative Group of morphologists, whose landmark 1976 and 1982 papers provided the first widely-used classification of MDS. More recent developments in the MDS field include new mechanistic biological insights, regulatory approval of several somewhat-effective treatments, and improved organizational support and advocacy. The history of a disease concept like MDS, as for history in general, provides both inspiration and cautionary tales that can inform present and future work.

  7. Historical Perspective on Mitochondrial Medicine (United States)

    DiMauro, Salvatore; Garone, Caterina


    In this review, we trace the origins and follow the development of mitochondrial medicine from the premolecular era (1962-1988) based on clinical clues, muscle morphology, and biochemistry into the molecular era that started in 1988 and is still advancing at a brisk pace. We have tried to stress conceptual advances, such as endosymbiosis,…

  8. Historical perspective of Indian neurology

    Directory of Open Access Journals (Sweden)

    Shrikant Mishra


    Full Text Available Objective: To chronicle the history of medicine and neurology in India with a focus on its establishment and evolution. Background: The history of neurology in India is divided into two periods: ancient and modern. The ancient period dates back to the mid-second millennium Before Christ (B.C. during the creation of the Ayurvedic Indian system of Medicine, which detailed descriptions of neurological disorders called Vata Vyadhi. The early 20 th century witnessed the birth of modern Indian medicine with the onset of formal physician training at the nation′s first allopathic medical colleges located in Madras (1835, Calcutta (1835 and Mumbai (1848. Prior to India′s independence from Britain in 1947, only 25 medical schools existed in the entire country. Today, there are over 355. In 1951, physicians across the field of neurology and neurosurgery united to create the Neurological Society of India (NSI. Four decades later in 1991, neurologists branched out to establish a separate organization called the Indian Academy of Neurology (IAN. Design/Methods: Information was gathered through literature review using PubMed, MD Consult, OVID, primary texts and research at various academic institutions in India. Results: Neurological disorders were first described in ancient India under Ayurveda. The transition to modern medicine occurred more recently through formal training at medical schools beginning in the 1930′s. Early pioneers and founders of the NSI (1951 include Dr. Jacob Chandy, Dr. B Ramamurthi, Dr. S. T. Narasimhan and Dr. Baldev Singh. Later, Dr. J. S. Chopra, a prominent neurologist and visionary, recognized the need for primary centers of collaboration and subsequently established the IAN (1991. The future of Neurology in India is growing rapidly. Currently, there are 1100 practicing neurologists and more than 150 post-graduate trainees who join the ranks every year. As the number of neurologists rises across India, there is an increase in the amount of basic, clinical and epidemiological research being conducted across the country every day. Conclusions: The history of neurology in India roots back to its rich culture and tradition. Over time, there has been great structural and organizational evolution and the future of neurology in India appears to be bright. However, the number of neurologists and research in neurology needs to experience a significant growth in the future to ensure the best patient care.

  9. Individuality and Literacy: Historical Perspective. (United States)

    Robbins, Rosemary A.

    The technology of literacy for any given culture helps to Determine the character of its members. In less than 3,000 years, Western culture has been transformed from an oral/aural culture through many increasingly literate phases to a present stage which is approaching "computer literacy." Erich Fromm suggests that in the course of…


    Energy Technology Data Exchange (ETDEWEB)

    Swegle, J.; Tincher, D.


    This is the first of three papers (in addition to an introductory summary) aimed at providing a framework for evaluating future reductions or modifications of the U.S. nuclear force, first by considering previous instances in which nuclear-force capabilities were eliminated; second by looking forward into at least the foreseeable future at the features of global and regional deterrence (recognizing that new weapon systems currently projected will have expected lifetimes stretching beyond our ability to predict the future); and third by providing examples of past or possible undesirable outcomes in the shaping of the future nuclear force, as well as some closing thoughts for the future. This paper examines the circumstances and consequences of the elimination of The INF-range Pershing II ballistic missile and Gryphon Ground-Launched Cruise Missile (GLCM), deployed by NATO under a dual-track strategy to counter Soviet intermediate-range missiles while pursuing negotiations to limit or eliminate all of these missiles. The Short-Range Attack Missile (SRAM), which was actually a family of missiles including SRAM A, SRAM B (never deployed), and SRAM II and SRAM T, these last two cancelled during an over-budget/behind-schedule development phase as part of the Presidential Nuclear Initiatives of 1991 and 1992. The nuclear-armed version of the Tomahawk Land-Attack Cruise Missile (TLAM/N), first limited to shore-based storage by the PNIs, and finally eliminated in deliberations surrounding the 2010 Nuclear Posture Review Report. The Missile-X (MX), or Peacekeeper, a heavy MIRVed ICBM, deployed in fixed silos, rather than in an originally proposed mobile mode. Peacekeeper was likely intended as a bargaining chip to facilitate elimination of Russian heavy missiles. The plan failed when START II did not enter into force, and the missiles were eliminated at the end of their intended service life. The Small ICBM (SICBM), or Midgetman, a road-mobile, single-warhead missile for which per-unit costs were climbing when it was eliminated under the PNIs. Although there were liabilities associated with each of these systems, there were also unique capabilities; this paper lays out the pros and cons for each. Further, we articulate the capabilities that were eliminated with these systems.

  11. Historical perspectives on interventional electrophysiology. (United States)

    Lüderitz, Berndt


    The history of interventional electrophysiology is long and fascinating. In the beginning, there is not simply the anatomy and physiology of the heart, but also analysis of the pulse, which indicates the activity of the heart. The analysis of the (peripheral) pulse as a mechanical expression of heart activity goes back several millennia. In China, in 280 B.C., Wang Chu Ho wrote ten books about the pulse. The Greeks called the pulse "sphygmos", and the sphygmology thus deals with a theory of this natural occurrence. In Roman times, Galen interpreted the various types of pulse according to the widespread presumption of the time, that each organ in every disease has its own form of pulse. The basic tool for arrhythmia diagnosis became the electrocardiography introduced by Willem Einthoven who obtained the first human electrogram 1902 in Leiden, The Netherlands. The growing clinical importance of electrical cardiac stimulation has been recognized and renewed as Zoll (1911-1999) in 1952 reported a successful resuscitation in cardiac standstill by external stimulation. Meanwhile all over the world, millions of patients with cardiac arrhythmias have been treated with pacemakers in the last 45 years. The concept of a fully automatic implantable cardioverter-defibrillator system (ICD) for recognition and treatment of ventricular tachyarrhythmias was first suggested in 1970. The first implantation of the device in a human being was performed in February 1980. Further developments concern atrial and atrioventricular defibrillators, radiofrequency ablation, laser therapy and advanced antiarrhythmic surgery, new antiarrhythmic drugs and sophisticated devices for preventive pacing. The advances in the field of diagnostic and therapeutic application of pharmacologic and electrical tools as well as alternative methods will continue as rapidly as before in order to give us further significant aid in taking care of the patient.

  12. Accountability--A Historical Perspective. (United States)

    Keefover, Karen Shade


    Asserts that existing accountability policies assume that a single behaviorist theory is the one best system for effective education. Examines the pitfalls of the one-system approach through the examples of John Stuart Mill's utilitarian upbringing and "Gradgrindism" in Charles Dickens' novel "Hard Times." (SK)

  13. Testosterone deficiency: a historical perspective

    Directory of Open Access Journals (Sweden)

    Eberhard Nieschlag


    Full Text Available The biological effects of the testes and testosterone are known since antiquity. Aristotle knew the effects of castration and his hypothesis on fertilization is one of the first scientific encounters in reproductive biology. Over centuries, castration has been performed as punishment and to produce obedient slaves, but also to preserve the soprano voices of prepubertal boys. The Chinese imperial (and other oriental courts employed castrates as overseers in harems who often obtained high-ranking political positions. The era of testis transplantation and organotherapy was initiated by John Hunter in London who transplanted testes into capons in 1786. The intention of his experiments was to prove the 'vital principle' as the basis for modern transplantation medicine, but Hunter did not consider endocrine aspects. Arnold Adolph Berthold postulated internal secretion from his testicular transplantation experiments in 1849 in Göttingen and is thus considered the father of endocrinology. Following his observations, testicular preparations were used for therapy, popularized by self-experiments by Charles-Edouard Brown-Séquard in Paris (1889, which can at best have placebo effects. In the 1920s Sergio Voronoff transplanted testes from animals to men, but their effectiveness was disproved. Today testicular transplantation is being refined by stem cell research and germ cell transplantation. Modern androgen therapy started in 1935 when Enrest Lacquer isolated testosterone from bull testes in Amsterdam. In the same year testosterone was chemically synthesized independently by Adolf Butenandt in Göttingen and Leopold Ruzicka in Basel. Since testosterone was ineffective orally it was either compressed into subcutaneous pellets or was used orally as 17α-methyl testosterone, now obsolete because of liver toxicity. The early phases of testosterone treatment coincide with the first description of the most prominent syndromes of hypogonadism by Klinefelter, by Kallmann, DelCastillo and Pasqualini. In the 1950s longer-acting injectable testosterone enanthate became the preferred therapeutic modality. In the 1950s and 1960s, research concentrated on the chemical modification of androgens in order to emphasize their anabolic effects. Although anabolic steroids have largely disappeared from clinical medicine, they continue to live an illegal life for doping in athletics. In the 1970s the orally effective testosterone undecanoate was added to the spectrum of preparations. Recent transdermal gels and long-acting injectable preparations provide options for physiological testosterone substitution therapy.

  14. Functional hemianopsia: a historical perspective. (United States)

    Gittinger, J W


    The controversial history of functional hemianopsia is reviewed from Briquet's 1859 monograph on 430 cases of hysteria, through the 19th century works of Charcot, Freud, and Janet, and the observations of Fox and Wilbrand and Saenger in the early 20th century. More recently, concepts of this entity have been clarified by modern binocular testing of visual fields.

  15. Cleft lip: The historical perspective

    Directory of Open Access Journals (Sweden)

    Bhattacharya S


    Full Text Available The earliest documented history of cleft lip is based on a combination of religion, superstition, invention and charlatanism. While Greeks ignored their existence, Spartans and Romans would kill these children as they were considered to harbour evil spirits. When saner senses prevailed Fabricius ab Aquapendente (1537-1619 was the first to suggest the embryological basis of these clefts. The knowledge of cleft lip and the surgical correction received a big boost during the period between the Renaissance and the 19th century with the publication of Pierre Franco′s Petit Traite and Traite des Hernies in which he described the condition as "lievre fendu de nativite" (cleft lip present from birth. The first documented Cleft lip surgery is from China in 390 BC in an 18 year old would be soldier, Wey Young-Chi. Albucasis of Arabia and his fellow surgeons used the cautery instead of the scalpel and Yperman in 1854 recommended scarifying the margins with a scalpel before suturing them with a triangular needle dipped in wax. The repair was reinforced by passing a long needle through the two sides of the lip and fixing the shaft of the needle with a figure-of-eight thread over the lip. Germanicus Mirault can be credited to be the originator of the triangular flap which was later modified by C.W. Tennison in 1952 and Peter Randall in 1959. In the late 50s, Ralph Millard gave us his legendary ′cut as you go′ technique. The protruding premaxilla of a bilateral cleft lip too has seen many changes throughout the ages - from being discarded totally to being pushed back by wedge resection of vomer to finally being left to the orthodontists.

  16. Cognitive Dominance: A Historical Perspective (United States)


    and knew how to maximize everyone’s strengths. When issuing orders, the commanders spent considerable time explaining information they needed to...advantage was in his ability to maximize use of existing resources using his mind.14 France’s neighbors faced a tremendous, existential challenge...including classic literature, poetry , religion, history, geography, and philosophy. Napoleon’s preparation took a great deal of work, something that

  17. Peyronie's Disease: A Historical Perspective. (United States)

    Carriere, Stephen P; Pytell, Jarratt D; Saltzman, Amanda F; Fuselier, Harold A


    Peyronie's disease (PD), more commonly known as penile curvature, is caused by plaque formation in the connective tissue of the penis. PD affects 0.3% to 8.9% of men, most commonly between ages 40 and 60 years and can cause significant psychological distress, regardless of severity. There is a rich history behind the initial reports of PD, initial beliefs about pathogenesis, and initial treatment. This article aims to discuss the history of PD as well as the evolution of causes and treatments throughout time up to present-day theories of pathogenesis and treatment.

  18. The Historical Perspective of the Study of Medieval Aesthetics%中古美学研究的历史视角

    Institute of Scientific and Technical Information of China (English)



    For a long time,"Aesthetics" as a word is always very holy for us. It seems to have a sense of transcendence and purity when we refer to the Aesthetics or aesthetic problems. In the study of aesthetics or aesthetic history, most of people are not willing to re⁃search for the social and historical foundation of aesthetic activities and the formation process of aesthetic ideas, instead taking a static and synchronic point of view as a start for research work. But in fact, as like any other social and cultural phenomenon, aesthetic ques⁃tions are the products of history, be restricted to specific historical conditions, play some kind of social functions, and be constructed in accordance with certain rules. In the previous studies, medieval aesthetics also has a tendency of being holy for us, and attracts us to it, such as "Wei Jin demeanor","sound of Zhengshi","seven sages of bamboo grove", etc. However, if we research medieval aes⁃thetics from the historical perspective, we will find that there are not only political or ideological interests, but also all kinds of contra⁃dictions and conflicts in it. As far as the mainstream of medieval aesthetics is concerned, it embodies the aesthetic taste of the intelli⁃gentsia. However, as a special class, they were originated from the scholar-officials of Qin and Han Dynasties, in a word, nobility scholars. For them, aesthetic taste plays an important role in the justification of their privileged identity, and undertakes the historical function of class distinction.%长期以来,“美学”一直是一个很神圣的词语,似乎涉及“美学”或“审美”问题时总会有那么一点不食人间烟火、超尘拔俗的味道。人们在研究美学或美学史问题时,也往往是从静态的、共时性的角度出发的,不大愿意去追索在“审美”背后蕴含的社会历史原因及其生成过程。而事实上,美学问题也和其他任何社会文化现象一样,都是历史的产

  19. Herbicide toxicity, selectivity and hormesis of nicosulfuron on 10 Trichogrammatidae (Hymenoptera) species parasitizing Anagasta ( = Ephestia) kuehniella (Lepidoptera: Pyralidae) eggs. (United States)

    Leite, Germano L D; de Paulo, Paula D; Zanuncio, José C; Tavares, Wagner De S; Alvarenga, Anarelly C; Dourado, Luan R; Bispo, Edilson P R; Soares, Marcus A


    Selective agrochemicals including herbicides that do not affect non-target organisms such as natural enemies are important in the integrated pest management (IPM) programs. The aim of this study was to evaluate the herbicide toxicity, selectivity and hormesis of nicosulfuron, recommended for the corn Zea mays L. (Poaceae) crop, on 10 Trichogrammatidae (Hymenoptera) species. A female of each Trichogramma spp. or Trichogrammatoidea annulata De Santis, 1972 was individually placed in plastic test tubes (no choice) with a cardboard containing 45 flour moth Anagasta ( = Ephestia) kuehniella Zeller, 1879 (Lepidoptera: Pyralidae) eggs. Parasitism by these natural enemies was allowed for 48 h and the cardboards were sprayed with the herbicide nicosulfuron at 1.50 L.ha(-1), along with the control (only distilled water). Nicosulfuron reduced the emergence rate of Trichogramma bruni Nagaraja, 1983 females, but increased that of Trichogramma pretiosum Riley, 1879, Trichogramma acacioi Brun, Moraes and Smith, 1984 and T. annulata females. Conversely, this herbicide increased the emergence rate of Trichogramma brasiliensis Ashmead, 1904, T. bruni, Trichogramma galloi Zucchi, 1988 and Trichogramma soaresi Nagaraja, 1983 males and decreased those of T. acacioi, Trichogramma atopovilia Oatman and Platner, 1983 and T. pretiosum males. In addition, nicosulfuron reduced the sex ratio of T. galloi, Trichogramma bennetti Nagaraja and Nagarkatti, 1973 and T. pretiosum and increased that of T. acacioi, T. bruni, T. annulata, Trichogramma demoraesi Nagaraja, 1983, T. soaresi and T. brasiliensis. The herbicide nicosulfuron was "harmless" (class 1, <30% reduction) for females and the sex ratio of all Trichogrammatidae species based on the International Organization for Biological Control (IOBC) classification. The possible hormesis effect of nicosulfuron on Trichogrammatidae species and on the bacterium Wolbachia sp. (Rickettsiales: Rickettsiaceae) was also discussed.

  20. Diachronic Perspective and Interaction

    DEFF Research Database (Denmark)

    Marchetti, Emanuela; Valente, Andrea

    . An ongoing participatory inquiry is being conducted, to explore deeper forms of learning and communication for historical museums. Our hypothesis is that the diachronic perspective on historical processes, defined as social interaction within the environment through time, is a key missing element....... Explorations of more interactive representations of the diachronic perspective, through play and tangible interaction, may foster a dialogue with young visitors. Therefore, a new interactive installation is being designed, intended as a tool to enrich learning, allowing children to experience historical...

  1. Historical blunders: how toxicology got the dose-response relationship half right. (United States)

    Calabrese, E J


    Substantial evidence indicates that reliable examples of hormetic dose responses in the toxicological literature are common and generalizable across biological model, endpoint measured and chemical class. Further evaluation revealed that the hormetic dose response model is more common than the threshold dose response model in objective, head-to-head comparisons. Nonetheless, the field of toxicology made a profound error by rejecting the use of the hormetic dose response model in its teaching, research, risk assessment and regulatory activities over nearly the past century. This paper argues that the hormetic dose response model (formerly called the Arndt-Schulz Law) was rejected principally because of its close historical association with the medical practice of homeopathy as a result of the prolonged and bitter feud between traditional medicine and homeopathy. Opponents of the concept of hormesis, making use of strong appeals to authority, were successful in their misrepresentation of the scientific foundations of hormesis and in their unfair association of it with segments of the homeopathic movement with extreme and discreditable views. These misrepresentations became established and integrated within the pharmacology and toxicology communities as a result of their origins in and continuities with traditional medicine and subsequently profoundly impacted a broad range of governmental risk assessment activities further consolidating the rejection of hormesis. This error of judgment was reinforced by toxicological hazard assessment methods using only high and few doses that were unable to assess hormetic responses, statistical modeling processes that were constrained to deny the possibility of hormetic dose response relationships and by the modest nature of the hormetic stimulatory response itself, which required more rigorous study designs to evaluate possible hormetic responses.

  2. Selective toxin effects on faster and slower growing individuals in the formation of hormesis at the population level - A case study with Lactuca sativa and PCIB. (United States)

    Belz, Regina G; Sinkkonen, Aki


    Natural plant populations have large phenotypic plasticity that enhances acclimation to local stress factors such as toxin exposures. While consequences of high toxin exposures are well addressed, effects of low-dose toxin exposures on plant populations are seldom investigated. In particular, the importance of 'selective low-dose toxicity' and hormesis, i.e. stimulatory effects, has not been studied simultaneously. Since selective toxicity can change the size distribution of populations, we assumed that hormesis alters the size distribution at the population level, and investigated whether and how these two low-dose phenomena coexist. The study was conducted with Lactuca sativa L. exposed to the auxin-inhibitor 2-(p-chlorophenoxy)-2-methylpropionic acid (PCIB) in vitro. In two separate experiments, L. sativa was exposed to 12 PCIB doses in 24 replicates (50 plants/replicate). Shoot/root growth responses at the population level were compared to the fast-growing (≥90% percentile) and the slow-growing subpopulations (≤10% percentile) by Mann-Whitney U testing and dose-response modelling. In the formation of pronounced PCIB hormesis at the population level, low-dose effects proved selective, but widely stimulatory which seems to counteract low-dose selective toxicity. The selectivity of hormesis was dose- and growth rate-dependent. Stimulation occurred at lower concentrations and stimulation percentage was higher among slow-growing individuals, but partly or entirely masked at the population level by moderate or negligible stimulation among the faster growing individuals. We conclude that the hormetic effect up to the maximum stimulation may be primarily facilitated by an increase in size of the most slow-growing individuals, while thereafter it seems that mainly the fast-growing individuals contributed to the observed hormesis at the population level. As size distribution within a population is related to survival, our study hints that selective effects on slow

  3. Comparative phylogeny and historical perspectives on population genetics of the Pacific hawksbill (Eretmochelys imbricata) and green turtles (Chelonia mydas), inferred from feeding populations in the Yaeyama Islands, Japan. (United States)

    Nishizawa, Hideaki; Okuyama, Junichi; Kobayashi, Masato; Abe, Osamu; Arai, Nobuaki


    Mitochondrial DNA sequence polymorphisms and patterns of genetic diversity represent the genealogy and relative impacts of historical, geographic, and demographic events on populations. In this study, historical patterns of population dynamics and differentiation in hawksbill (Eretmochelys imbricata) and green turtles (Chelonia mydas) in the Pacific were estimated from feeding populations in the Yaeyama Islands, Japan. Phylogenetic relationships of the haplotypes indicated that hawksbill and green turtles in the Pacific probably underwent very similar patterns and processes of population dynamics over the last million years, with population subdivision during the early Pleistocene and population expansion after the last glacial maximum. These significant contemporary historical events were suggested to have been caused by climatic and sea-level fluctuations. On the other hand, comparing our results to long-term population dynamics in the Atlantic, population subdivisions during the early Pleistocene were specific to Pacific hawksbill and green turtles. Therefore, regional differences in historical population dynamics are suggested. Despite limited sampling locations, these results are the first step in estimating the historical trends in Pacific sea turtles by using phylogenetics and population genetics.

  4. A Cultural Historical Activity Theory Perspective to Understand Preservice Science Teachers' Reflections on and Tensions during a Microteaching Experience (United States)

    Sezen-Barrie, Asli; Tran, Minh-Dan; McDonald, Scott P.; Kelly, Gregory J.


    This study draws from cultural historical activity theory (CHAT) to analyze preservice teachers' reflections on a microteaching activity. Microteaching activities involved preservice educators teaching middle school students from local schools. The study was conducted with 23 preservice teachers enrolled in a large university's teacher…

  5. Mitigating the consequences of future earthquakes in historical centres: what perspectives from the joined use of past information and geological-geophysical surveys? (United States)

    Terenzio Gizzi, Fabrizio; Moscatelli, Massimiliano; Potenza, Maria Rosaria; Zotta, Cinzia; Simionato, Maurizio; Pileggi, Domenico; Castenetto, Sergio


    To mitigate the damage effects of earthquakes in urban areas and particularly in historical centres prone to high seismic hazard is an important task to be pursued. As a matter of fact, seismic history throughout the world informs us that earthquakes have caused deep changes in the ancient urban conglomerations due to their high building vulnerability. Furthermore, some quarters can be exposed to an increase of seismic actions if compared with adjacent areas due to the geological and/or topographical features of the site on which the historical centres lie. Usually, the strategies aimed to estimate the local seismic hazard make only use of the geological-geophysical surveys. Thorough this approach we do not draw any lesson from what happened as a consequences of past earthquakes. With this in mind, we present the results of a joined use of historical data and traditional geological-geophysical approach to analyse the effects of possible future earthquakes in historical centres. The research activity discussed here is arranged into a joint collaboration between the Department of Civil Protection of the Presidency of Council of Ministers, the Institute of Environmental Geology and Geoengineering and the Institute of Archaeological and Monumental Heritage of the National (Italian) Research Council. In order to show the results, we discuss the preliminary achievements of the integrated study carried out on two historical towns located in Southern Apennines, a portion of the Italian peninsula exposed to high seismic hazard. Taking advantage from these two test sites, we also discuss some methodological implications that could be taken as a reference in the seismic microzonation studies.

  6. Sexual Success after Stress? Imidacloprid-Induced Hormesis in Males of the Neotropical Stink Bug Euschistus heros (United States)

    Haddi, Khalid; Mendes, Marcos V.; Lino-Neto, José; Freitas, Hemerson L.; Guedes, Raul Narciso C.; Oliveira, Eugênio E.


    Environmental stress in newly-emerged adult insects can have dramatic consequences on their life traits (e.g., dispersion, survival and reproduction) as adults. For instance, insects sublethally exposed to environmental stressors (e.g., insecticides) can gain fitness benefits as a result of hormesis (i.e., benefits of low doses of compounds that would be toxic at higher doses). Here, we experimentally tested whether sublethal exposure to the insecticide imidacloprid would hormetically affect the sexual fitness of newly-emerged adults of the Neotropical brown stink bug Euschistus heros (Hemiptera: Heteroptera: Pentatomidae), which is the most abundant and prevalent insect pest in Neotropical soybean fields. We evaluated the sexual fitness of four couple combinations: unexposed couples, exposed females, exposed males, and exposed couples. Sublethal exposure to dry residues (i.e., contact) of imidacloprid (at 1% of recommended field rate) did not affect insect survival, but led to higher mating frequencies when at least one member of the couple was exposed. However, the average mating duration was shortened when only females were exposed to imidacloprid. Moreover, exposed males showed higher locomotory (walking) activity, lower respiration rates and induced higher fecundity rates when mated to unexposed females. Although the reproductive tracts of exposed males did not differ morphometrically from unexposed males, their accessory glands exhibited positive reactions for acidic and basic contents. Our findings suggest that males of the Neotropical brown stink bug hormetically increase their sexual fitness when cued by impending insecticidal stress in early adulthood. PMID:27284906

  7. Vegetable and synthetic tannins induce hormesis/toxicity in sea urchin early development and in algal growth

    Energy Technology Data Exchange (ETDEWEB)

    De Nicola, Elena [Italian National Cancer Institute, G. Pascale Foundation, via M. Semmola, I-80131 Naples (Italy); Meric, Suereyya [Department of Civil Engineering, Salerno University, I-84084 Fisciano (Italy); Gallo, Marialuisa [Campania Regional Agency for Environmental Protection (ARPAC), I-80143 Naples (Italy); Iaccarino, Mario [Italian National Cancer Institute, G. Pascale Foundation, via M. Semmola, I-80131 Naples (Italy); Della Rocca, Claudio [Department of Civil Engineering, Salerno University, I-84084 Fisciano (Italy); Lofrano, Giusy [Department of Civil Engineering, Salerno University, I-84084 Fisciano (Italy); Russo, Teresa [Campania Regional Agency for Environmental Protection (ARPAC), I-80143 Naples (Italy); Pagano, Giovanni [Italian National Cancer Institute, G. Pascale Foundation, via M. Semmola, I-80131 Naples (Italy)]. E-mail:


    Mimosa tannin and phenol-based synthetic tannin (syntan) were tested for toxicity to sea urchin (Paracentrotus lividus and Sphaerechinus granularis) early development and to marine algal growth (Dunaliella tertiolecta). Sea urchin embryogenesis was affected by vegetable tannin and syntan water extracts (VTWE and STWE) at levels {>=}1 mg/L. Developmental defects were significantly decreased at VTWE and STWE levels of 0.1 and 0.3 mg/L when control cultures displayed suboptimal quality, i.e. <70% 'viable' (normal or retarded) larvae. Fertilization success of sea urchin sperm was increased up to 0.3 mg/L STWE or VTWE, then was inhibited by increasing tannin levels (1-30 mg/L). Offspring abnormalities, following sperm exposure to VTWE or STWE, showed the same shift from hormesis to toxicity. Cell growth bioassays in D. tertiolecta exposed to VTWE or STWE (0.1-30 mg/L) showed non-linear concentration-related toxicity. Novel criteria are suggested in defining control quality that should reveal hormetic effects. - Vegetable tannin and synthetic tannins were moderately toxic or displayed hormetic effects in sea urchins and in algae. Re-defining control quality is needed for evaluating hormetic effects.

  8. A Historical Perspective of Deaf People and Its Constitution as aMeans of Social Movement in Brazil, in Contemporary Times

    Institute of Scientific and Technical Information of China (English)

    Ingrid Karla da Nobrega Beserra


    This paper aims to present the historical constitution of the Deaf Movement (Movimento Surdo) and theirrespective events and claims in the national socio-political scene. Among the numerous social movements operatingin the country and the world we identified the Deaf Movement while present in the social struggles and the poorvisibility conferred on it in the context of listener culture, considering their undeniable importance in the currentform of society. Search up from the use of surveys and interviews to understand this movement as the set of actionsdeveloped by the deaf community around the historical issues, identity, cultural, social and political. Among themany claims of this movement highlights the proposed bilingual education for deaf people seeking socialknowledge of deafness would mean not only the best form of education for the deaf, but also for themaintenance/affirmation of deaf culture.

  9. Contemporary Capitalism and the Building of Harmonious Society in World Historical Perspectives%世界历史视角·当代资本主义与和谐世界建构

    Institute of Scientific and Technical Information of China (English)



    World historical perspectives are views and approaches derived from the mutual connections among nations and countries, which are of critical epistemological importance. World historical perspectives must be adopted to perceive contemporary capitalism and chart the blueprint of human future. Contemporary capitalism is state monopoly capitalism, which is the full embodiment of systematic defects, giving rise to socialist factors and global polarization between extreme richness and poverty. Global polarization is the major demonstration of capitalist corruption. While it is fundamental to replace capitalism with socialism in the worldwide for mankind to get a way out, a feasible road to address current global problems is to build a harmonious world.%世界历史视角有着重要的认识功能,必须用世界历史视角来认识当代资本主义和规划人类的出路。当代资本主义是国家垄断资本主义,是制度性缺陷充分暴露、萌生了一些社会主义因素、造成全球贫富两极分化的资本主义。而全球两极分化是当代资本主义腐朽性的主要表现。人类出路的根本取向是在全世界用社会主义取代资本主义,而在当前解决全球性问题的一条现实道路则是构建和谐世界。

  10. Negotiating the Process of Historical Empathy (United States)

    Endacott, Jason L.


    Historical empathy scholarship has evolved to the point where further progress necessitates empirical examinations from a variety of perspectives. Prior studies on historical empathy have largely focused on teachers' pedagogical approach and student outcomes. This qualitative study focuses on students as they engage in the process of…

  11. 有毒物质Hormesis效应的识别与评价%Ways to identify and evaluate the Hormesis induced by toxic substances

    Institute of Scientific and Technical Information of China (English)

    朱鸿林; 张燕; 赏国锋; 沈国清


    有毒物质Hormesis效应对传统的毒理学模型提出了挑战.在低剂量条件下单纯的效应增强并不一定是Hormesis效应,可能由效应的某种波动或试验误差引起.对有毒物质Hormesis效应特征、发生的低剂量范围及其识别与评价方法进行了综述,并以低剂量镉对蚯蚓体内谷胱甘肽过氧化物酶(GSH - PX)活性影响为例,建立了Hormesis效应及其定量评价方法.结果表明,二次函数拟合模型为y=0.3994- 1.4472X2+ 1.707X,刺激效应强度为45.34%.%The present paper takes as its objective to provide ways to identify and evaluate the hormesis induced by toxic substances. Great challenges have been brought about to the traditional model of toxicology, and the general stimulation at low-dose began to attract more and more attention both at home and abroad. However, the current research advances in this aspect are mostly based on the accumulated observation results compared to the control at low-dosages. Nevertheless , merely enhanced responses at low doses may not be likely to reveal fully the characteristics of hormesis but a random fluctuation in the response process. Thus, it can be said that the key problem leading to the inefficient identification and evaluation of hormesis lies in the lack of identification and evaluation means. Therefore, in this paper, we have first of all summarized the characteristic features of hormesis, the relation of low-dose range and the evaluation methods, and, what is more, worked out a new approach to the development of hormesis. To illustrate how to use the method, we have made attempt to apply it to the data analysis due to the influence of the low dose cadmium on the glutathione peroxidase (GSH - PX) activity in the earthworms. The results of our experiments show that cadmium at low concentrations tends to induce the stimulation of GSH - PX activity, whereas high concentrations tend to result in inhibition. To make the data fit the quadratic functions

  12. Immmigrants and their associations: A global and historical perspective Los inmigrantes y sus asociaciones: Una perspectiva histórica y global

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    José C. Moya


    sociability. The paper addresses the class and gender composition of memberships, compares the associative practices of the late 19th century’s immigrants with those of the early 21st century, and discusses the issue of state involvement. The essay shows, from a global and historical perspective, how quasi-universal processes and local and temporal specificities shaped associational practices in a way that transcended the ethno-national traditions and characteristics of particular immigrant groups and host countries.

  1. 什么是生命伦理学?——从历史发展的视角%What is bioethics: from perspective of historical development

    Institute of Scientific and Technical Information of China (English)



    生命伦理学是20世纪60年代兴起于美国的一门新兴学科,旨在应对生命科学和生物技术的发展或医疗保健的演变使人类面临的种种伦理难题.生命伦理学的兴起有着特殊的社会历史背景.它在发展过程中出现的一些里程碑式的案例,对生命伦理学的发展产生了深远的影响.从其发展特征上看,生命伦理学和医学伦理学紧密联系,有着更为广泛的研究内容和独特的专业特性.生命伦理学要有效回应现代医学和生命科学的发展给人类带来的伦理难题,既要准确地界定伦理问题,又要以适当的方式将伦理学基础理论应用到具体问题当中.对生命伦理学的基本理论进行概述.%Bioethics is an emerging discipline originating in America of the 1960s, aiming to bridge between life science, biomedical technology, health care and ethics. Bioethics originated under particular social historical contexts; Some events or cases which happened as the cornerstone in the history have profound influences on the development of bioethics. With respect to its developmental features, even though bioethics historical linked with medical ethics, it owns broader contents and unique characteristics. In order to answer ethical dilemmas caused by the developments of contemporary medicine and life science, bioethics firstly needs to define ethical issues correctly, then apply fundamental theories of ethics to concrete scenarios in appropriate ways. This paper also makes a briefly introduction of the basic theories of bioethics.

  2. Southern Cone Initiative for the elimination of domestic populations of Triatoma infestans and the interruption of transfusional Chagas disease. Historical aspects, present situation, and perspectives. (United States)

    Dias, João Carlos Pinto


    Created in 1991 by the governments of Argentina, Bolivia, Brazil, Chile, Paraguay, and Uruguay, the Southern Cone Initiative (SCI) has been extremely important for Chagas disease control in this region. Its basic objective was to reach the interruption of this disease, chiefly by means of the elimination of the principal vector Triatoma infestans and by the selection of safe donors in the regional blood banks. After a summarized historic of SCI, the text shows the advance of technical and operative activities, emphasizing some factors for the initiative success, as well as some difficulties and constraints. The future of SCI will depend of the continuity of the actions and of political priority. Scientific community has been highly responsible for this initiative and its maintenance. At the side of this, national and international efforts must be involved and reinforced to assure the accomplishment of the final targets of SCI. Very specially, the Pan American Health Organization has cooperated with the Initiative in all its moments and activities,being the most important catalytic and technical factor for SCI success.

  3. Southern Cone Initiative for the elimination of domestic populations of Triatoma infestans and the interruption of transfusion Chagas disease: historical aspects, present situation, and perspectives

    Directory of Open Access Journals (Sweden)

    João Carlos Pinto Dias


    Full Text Available Created in 1991 by the governments of Argentina, Bolivia, Brazil, Chile, Paraguay, and Uruguay, the Southern Cone Initiative (SCI has been extremely important for Chagas disease control in this region. Its basic objective was to reach the interruption of this disease, chiefly by means of the elimination of the principal vector Triatoma infestans and by the selection of safe donors in the regional blood banks. After a summarized historic of SCI, the text shows the advance of technical and operative activities, emphasizing some factors for the initiative success, as well as some difficulties and constraints. The future of SCI will depend of the continuity of the actions and of political priority. Scientific community has been highly responsible for this initiative and its maintenance. At the side of this, national and international efforts must be involved and reinforced to assure the accomplishment of the final targets of SCI. Very specially, the Pan American Health Organization has cooperated with the Initiative in all its moments and activities,being the most important catalytic and technical factor for SCI success.

  4. Analysis of "hedonism" from the perspective of historical materialism%从唯物史观的视角分析“享乐主义”

    Institute of Scientific and Technical Information of China (English)

    冯石岗; 王静涛


    Historical materialism teaches us that social existence determines social consciousness, social consciousness develops with the development of social existence. Social ideology has a dynamic reaction to social existence, "hedonism" belongs to social consciousness, is decided by social existence. Hedonism is a mistake of social consciousness, which hinder the development of society, we must resolutely resist hedonism.%唯物史观教导我们:社会存在决定社会意识,社会意识随着社会存在的发展而发展。社会意识对社会存在有能动的反作用,“享乐主义”属于社会意识层面,是由社会存在决定的。享乐主义是一种错误的社会意识,它阻碍社会的发展,我们要坚决抵制享乐主义。

  5. 敦煌城与莫高窟的历史概观%Historical Perspective on Dunhuang and the Mogao Caves

    Institute of Scientific and Technical Information of China (English)



    Based on study of the mural of Zhang Qian’s exploration of the Western Region depicted in Mo-gao Cave 323, an Eastern Han dynasty bamboo slip which records a Buddhist pagoda in Dunhuang, and other relevant historical documents,this paper discusses the Buddhist history in Dunhuang and demonstrates the evolu-tion of Buddhist art styles of Mogao and the importance of this art in the history of Chinese Buddhism.%结合相关文献证据,通过考察敦煌莫高窟有关佛教传入中国的壁画以及最早记载敦煌佛教痕迹的一枚东汉汉简,探讨了敦煌佛教发展过程、阐释了莫高窟佛教艺术风格的流变及其在中国佛教史上的重要意义。

  6. Experiencing the “refugee crisis” through the Intervention into the Public Discourse: Us as the Others in the Historical Perspective of Slovenian Emigration and Integration Practices

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    Mirjam Milharčič Hladnik


    Full Text Available In Slovenia the so called refugee crisis lasted from October 2015 to March 2016, when the Balkan route was closed. The public discourse in this time had the characteristic of moral panic; it abruptly started when the Hungarian government closed the border with Serbia and Croatia, forcing masses of migrants to take the route to “Germany” via Slovenia, and as abruptly ended with the closure of the Balkan route. The subjective experience with the period of intense public interest in migration is described through many interventions by the author, who happened to be one of the many experts who were asked to comment on the “refugee crisis”. Each intervention was intentionally the same, and addressed the same two clusters of public fears: first, the masses of migrants and refugees as a natural disaster that would destroy “everything”, and, second, the impossibility of integration of masses of migrants into European and Slovenian societies. Each intervention insisted, first, on the forgotten historical facts about the intense migrations that have been a crucial part of the formations of Europe’s ethnically, religiously, linguistically and culturally diverse and mixed populations and societies, and, second, on the forgotten facts about the recent successful integration practices that have evolved in Europe and Slovenia in the past fifty years and enabled them to become and remain economically and socially stable and safe.

  7. 《鲁谼方氏族谱》的历史社会学解读%The Interpretation of Luhong Fang Family Genealogy from the Perspective of Historical Sociology

    Institute of Scientific and Technical Information of China (English)



    近年来,随着我国经济社会的快速发展,民间续修族谱活动逐渐兴起,人们更多地给予族谱以正面的新认识。人们从族谱记载家族世系等情况中,可以了解姓氏源流、家族兴替、人口迁徙、族习门风乃至社会变故等历史,赋予族谱一定的历史价值与社会意义。《鲁谼方氏族谱》由桐城派古文家方东树撰修,具有较高的历史文献价值,折射出社会变迁与文化传承。受学术风气与交叉学科的影响,人们解读族谱的方式有所变化,族谱学研究的视野不断扩展,从历史社会学的角度解读族谱亦是一种尝试。%In recent years, with the rapid economic and social development of China, the activities of editing genealogy are gradually on the rise, which makes more and more people take new positive understanding of it. From the family lineage recorded in genealogy, people can get to know the family history, such as origin of the family name, rise and fall of the family, population migration, customs and moral standing, as well as social changes, which give genealogy certain historical value and social significance. The Luhong Fang Family Genealogy, which was written by Fang Dongshu,the Tongcheng school prose master, reflects social changes and cultural inheritance, and embodies high historical and cultural value. Under the influence of academic atmosphere and interdisciplinary, the horizon of genealogy research is expanding, which changes the way of people’s understanding of genealogy. To interpret genealogy from the perspective of historical sociology is also an attempt.

  8. 建设马克思主义学习型政党的历史透视%Historical Perspective on Building a Marxist Learning Party

    Institute of Scientific and Technical Information of China (English)



    中国共产党始终注重学习马克思主义理论,并不断将其与中国实际相结合,努力实现马克思主义中国化。党学习马克思主义理论,在党创立后的前30年,着重从思想上建设党,确立了正确的思想和政治路线,实现了马克思主义中国化第一次历史性飞跃,取得了新民主主义革命伟大胜利;在第二个"30年",对适合中国情况的社会主义建设道路进行了艰苦的探索,教训十分深刻;在最近的"30年",党从号召学习马克思主义理论走向建设马克思主义学习型政党,期间现实了马克思主义中国化第二次历史性飞跃,从而取得了中国特色社会主义事业的伟大成就。党建设马克思主义学习型政党的历史给予我们许多重要启示。%The Communist Party of China has always attached great importance to the learning of Marxist theory and keeps its integration with Chinese reality.The Party has tried to realize the adaption of Marxism to Chinese conditions.The Party's study of Marxism has three "30 year" periods.In the first 30 years after the founding of the Party,she emphasized to build the Party ideologically,established correct ideological and political lines,realized the first historic leap in adapting Marxism to Chinese conditions,and won a great victory in the new democratic revolution;in the second 30 years,the Party conducted hard exploration and got poignant lesson for a road suited to Chinese conditions of building socialism;in the recent 30 years,the Party moved from calling for studying Marxist theory toward building a Marxist learning party,realized the second historic leap in adapting Marxism to Chinese conditions in the meantime,and achieved great accomplishments in the cause of socialism with Chinese characteristics.The Party's history of building a Marxist learning party provides us numerous important inspirations.

  9. Organic Carbon Dynamics beyond the Perspective of Monitoring: Impact of Historical Landscape Utilization on the Past Lake-Water Carbon Trajectory in Central Boreal Sweden (United States)

    Meyer-Jacob, C.; Tolu, J.; Bigler, C.; Bindler, R.


    To date, the key drivers behind the recent observed increase in organic carbon (OC) concentrations in surface waters are still controversial. The lack of long-term monitoring data - over centuries and millennia - leaves us with an ambiguous understanding of the past trajectory of OC concentrations in surface waters, and inhibits a better mechanistic understanding of past and a reliable prediction of future changes in OC levels.By using a paleolimnological approach, we reconstructed past lake-water total organic carbon (TOC) concentrations in lakes across the boreal landscape of central Sweden. Reconstructions are based on a transfer function between visible near-infrared spectra of surface sediments and the corresponding TOC concentration in the water column. Potential drivers behind changes in TOC were determined by a multi-proxy analysis of one of the studied lake sediment records including organic and inorganic geochemistry as well as biological proxies (pollen, diatoms).Our results show a significant decrease in lake-water TOC beginning already ~550 years ago. This decline continued until the mid-20th century when TOC concentrations started to increase again. These dynamics in TOC coincide with changes in proxies indicating catchment disturbance by human activities. The chronology of these changes corresponds to the expansion and decline of a landscape-wide system of summer forest grazing and farming in central Sweden from the 15th century to the turn of the 20th century. Frequent grazing and exploitation of forests and mires reduce aboveground vegetation and physically disturb soils. This further affects the carbon cycling by enhancing carbon turnover, reducing the thickness of organic soils and consequently altering the transport of OC from the catchment to lakes.Our findings suggest that recent changes in lake-water TOC in Sweden are strongly associated with historical patterns in land use and not only on-going changes in climate or sulfur deposition.

  10. Plants as De-Worming Agents of Livestock in the Nordic Countries: Historical Perspective, Popular Beliefs and Prospects for the Future

    Directory of Open Access Journals (Sweden)

    Ingebrigtsen K


    Full Text Available Preparations derived from plants were the original therapeutic interventions used by man to control diseases (including parasites, both within humans and livestock. Development of herbal products depended upon local botanical flora with the result that different remedies tended to develop in different parts of the world. Nevertheless, in some instances, the same or related plants were used over wide geographic regions, which also was the result of communication and/or the importation of plant material of high repute. Thus, the Nordic countries have an ancient, rich and diverse history of plant derived anthelmintic medications for human and animal use. Although some of the more commonly used herbal de-wormers were derived from imported plants, or their products, many are from endemic plants or those that thrive in the Scandinavian environment. With the advent of the modern chemotherapeutic era, and the discovery, development and marketing of a seemingly unlimited variety of highly efficacious, safe synthetic chemicals with very wide spectra of activities, herbal remedies virtually disappeared from the consciousness – at least in the Western world. This attitude is now rapidly changing. There is a widespread resurgence in natural product medication, driven by major threats posed by multi-resistant pest, or disease, organisms and the diminishing public perceptions that synthetic chemicals are the panacea to health and disease control. This review attempts to provide a comprehensive account of the depth of historical Nordic information available on herbal de-wormers, with emphasis on livestock and to provide some insights on potentially rewarding areas of "re-discovery" and scientific evaluation in this field.


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    Sheju Thomas


    Full Text Available Hindu pilgrimage sites in India always experience tremendous influxes of pilgrims and they are eventually subjected to considerable environmental impact. This article demonstrates how this sacred wetland has been established, and how since then it has been a religious – urban place which receives thousands of pilgrims daily. The present review is the case study of one of the anthropogenicfreshwater wetland ecosystem of viz. Gomti Pond of Dakor Town, Kheda District of Central Gujarat, India. The pond is one of the esteemed and religious Hindu pilgrimage places, associated with exodus of Lord Krishna and his devotee Bodana. Geographically, the place is a regional province, fringed by mainly three districts viz. Anand, Kheda (Charotar and Ahmedabad, reflected by identical culture, heritage, traditions, rites, and rituals. The present article has been prepared referring to various printed and on-line published literatures, visiting the place several times, and gathering information from the locals by semi-structured questionnaires. Besides, the screening of the entire area was done and a complete scenario was observed. This article delineates how the most sacred town ‘Dakor’ got recognized as a renowned pilgrimage spot, attracting the people from all over the State and the Country for its splendid historical significance, vivid geographical features, natural habitats, prevalent biotic community, variegated human population, and its holistic scenario. Keeping in mind the future challenges and projected perceptions about Gomti Pond, Dakor, many questions are still to be unanswered about how it is losing its natural habitats and biotic components. The information provided in the form of an article undoubtedly offers an insight for better understanding the environmental aspects to be addressed effectively for its better protection, conservation and management

  12. Surrendering to the Big Picture: Historical and Legal Perspectives on Accountability in the Democratic Republic of Congo Following the Defeat of the March 23 Movement

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    Janet McKnight


    Full Text Available It remains to be seen whether the past few months will mark a genuine turning point in the conflict in eastern Democratic Republic of Congo (DRC, as the rebel faction March 23 Movement (M23 announced the end of its 20-month insurgency against the government on 5 November 2013. News of the rebel group’s surrender following its political and military defeat signals an important moment of hope and renewed prospects of peace and stability in a region prone to protracted armed conflict. However, long-term stability in the country and in the region will require a multi-faceted process consisting of comprehensive accountability for human rights violations that have been committed by all parties to the conflict. In this article, I will first lay out the historical context of the fighting and the root causes of conflict present long before M23’s entrance onto the scene as a splintered rebel faction so as to understand M23’s place within the country’s history of protracted violence. Next, I will explain the violations of international humanitarian and human rights law committed by all possible parties, including rebel and government groups, as well as individual criminal responsibility and corporate liability. Lastly, I will chart the pathways of criminal and social accountability at various levels of international and domestic justice systems to see how the DRC may continue to build long-term local stability in the eastern parts of the country by addressing the question of accountability for international crimes. This brief analysis aims to provide a broader understanding of a complex conflict beyond the defeat and disarmament of M23, albeit a key group in a region of contentious cross-border conflict.

  13. La enseñanza del cine en España: perspectiva histórica y panorama actual Cinema teaching in Spain. A historical perspective and a contemporary view

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    Eduardo Rodríguez Merchán


    Full Text Available El artículo trata de ofrecer una perspectiva histórica de la enseñanza superior del cine en España, desde sus orígenes en los años cuarenta hasta la actualidad. Dada la complejidad del mapa actual de titulaciones, cursos, talleres y propuestas docentes sobre la cinematografía, se ofrece también un cuadro sinóptico bastante amplio de las asignaturas universitarias vinculadas al cine –al margen de las troncales de Comunicación Audiovisual– que se ofrecen en los centros de enseñanza superior de las distintas Comunidades Autónomas. This paper tries to offer a historical perspective of higher cinema teaching in Spain, from its origins in the 40s to the present. The current map of official studies in film, courses, workshops, seminars, etc., in Spain is very complex. This is the reason why we offer a complete diagram of university subjects related to the cinema in higher education in all the autonomous regions.

  14. On the Inevitability and Importance of Civic Education from the Perspective of Historical Materialism%从历史唯物主义的角度看公民教育存在的必然性与重要性

    Institute of Scientific and Technical Information of China (English)



    The existence of civic education has its necessity and importance,for it advents and develops with the development and change of human society from the perspective of historical materialism,so we can see that the history of human development determines the identity and status of civic education.At present,civic education has become an indispensable content of education system for a country,for it plays an important role in unifying civic ideology,standardizing limited behavior,and condensing force.%公民教育的存在有着必然性和重要性,从历史唯物主义的角度来看公民教育,可以了解其是跟随人类社会的发展变革而产生和发展的,是人类发展的历史决定了公民教育的身份与地位。当下,公民教育已经成为一个国家教育体系当中不可或缺的重要内容,在统一其公民意识形态、规范限制行为、凝聚力量等方面发挥着重要的作用。


    Kokowski, Michał


    The article sketches the history of naukoznawstwo (literally meaning the science connoisseurship or the science of science or science studies) in Poland from the 1910s to the end of the Cold War (1991), and the recovery of full political independence in 1993. It outlines the changing research perspectives of this interdisciplinary field of knowledge in Poland against a background of changing political conditions caused by the reconfigurations of the political order. The first part of the article concerns the period from the 1910s, when Poland was occupied by Russia, Prussia, and Austria, through the regaining of independence by Poland in 1918, the reconstruction of the state in 1918-1939; the second part--World War II; the third part--the period from the initial period of Soviet dominance (1944-1954) in Poland and simultaneously the beginnings of the Cold War (1947-1954), the period 1955-1956 (when the Polish state was liberated from Sovietization), through the different political crises in October 1956, March 1968, December 1970, and June 1976, to the emergence of the Independent Self-governing Trade Union Solidarity in September 1980, the end of the Cold War (1991), and the recovery of full political independence in 1993. The article outlines the fundamental achievements of prominent Polish scholars (among others K. Twardowski, M. Ossowska, S. Ossowski, T. Kotarbiński, K. Ajdukiewicz, S. Michalski, F. Znaniecki, B. Suchodolski, L. Fleck, M. Choynowski, Z. Modzelewski, S. Amsterdamski), politicians (among others B. Bierut, E. Krasowska), politicians and scholars (H. Jabłoński, S. Kulczyński), as well as committees (among others the Academic Section of the Józef Mianowski Fund, The Science of Science Committee of the Polish Academy of Sciences), schools of thought (among others the Lvov-Warsaw School of Philosophy), and academic units (among others the Science of Science Seminar in Kraków, the Department for the History of Science and Technology of the Polish

  16. Some notes on a historical perspective of panic disorder Algumas notas sobre uma perspectiva histórica do transtorno de pânico

    Directory of Open Access Journals (Sweden)

    Antonio Egidio Nardi


    Full Text Available This article aims to describe important points in the history of panic disorder concept, as well as to highlight the importance of its diagnosis for clinical and research developments. Panic disorder has been described in several literary reports and folklore. One of the oldest examples lies in Greek mythology - the god Pan, responsible for the term panic. The first half of the 19th century witnessed the culmination of medical approach. During the second half of the 19th century came the psychological approach of anxiety. The 20th century associated panic disorder to hereditary, organic and psychological factors, dividing anxiety into simple and phobic anxious states. Therapeutic development was also observed in psychopharmacological and psychotherapeutic fields. Official classifications began to include panic disorder as a category since the third edition of the American Classification Manual (1980. Some biological theories dealing with etiology were widely discussed during the last decades of the 20th century. They were based on laboratory studies of physiological, cognitive and biochemical tests, as the false suffocation alarm theory and the fear network. Such theories were important in creating new diagnostic paradigms to modern psychiatry. That suggests the need to consider a wide range of historical variables to understand how particular features for panic disorder diagnosis have been developed and how treatment has emerged.O objetivo deste artigo é descrever alguns pontos importantes na história do desenvolvimento do conceito de transtorno de pânico e ressaltar a importância do diagnóstico para o progresso da pesquisa e da clínica. O transtorno de pânico foi descrito em vários textos literários e folclóricos. Talvez um dos exemplos mais antigos seja o deus Pan da mitologia grega, responsável pelo termo pânico.Aprimeira metade do século XIX presenciou o apogeu do processo de abordagem médica. Durante a segunda metade do s


    Directory of Open Access Journals (Sweden)

    Claudia Milena Jaramillo


    German, and the American people. Despite the interests which hang over the Latin American university, from diverse glances (the experiences of Mexico, Peru, Guatemala, Argentina, Chile, and Colombia appear possibilities of considering the idea of restructuring an individual thinking which could recount a different identity that separates it from the Euro-centered discourse and places it in a perspective of analysis concerning the realities it has to deal with. In the configuration of the Latin American University, the following can stand out: Andrés Bello’s thought, José Vasconcellos’ ideas, and the implications of the Movement of Cordoba, as for the social and student movements with similar characteristics, which are directed toward the reflection about the need of making a decolonized change, not just as a matter of resistance, but of self-awareness of who we are and how to strengthen a common future. This is especially done in this epoch when the Latin American University is facing the attacks of globalization and the application of macro-economic policies that blur its social and academic being, undermining it.

  18. Historical Superbolides (United States)

    Sánchez de Miguel, A.; Zamora, S.; Ocaña, F.; Tapia, C.; de Burgos, A.; Herráiz, G.; Petrova, M.


    The amount of impacts of 50 m -- 1 cm asteroid with the Earth is a typical issue of controversy. Explosions in upper atmosphere and lunar impacts suggest that could have more impacts than is currently accepted. A ``new'' information source data can be fireballs appeared in historical press. Some of these reports indicate the presence of pressure waves or damage that may help estimate the energy of the event. We analysed more than 50 years of the archive of the New York Times and found a number of abnormally clustered events that can not be explained by a Poisson distribution. We have found at least two big concentrations not associated to any major meteor shower. One around the actual 23rd of July and other on the 14th of February. This second major concentration it is really close to the Chelyabinsk event date, so it is probable that there they are related. The preliminary results were published in Sánchez de Miguel, A., Ocaña, F., Zamora, S., et al. 2014, in Garzón Guerrero J. A., López Sánchez A. R., eds, Libro de Actas del XXI Congreso Estatal de Astronomía. Granada, Spain.

  19. Swimming microorganisms acting as nanorobots versus artificial nanorobotic agents: A perspective view from an historical retrospective on the future of medical nanorobotics in the largest known three-dimensional biomicrofluidic networks. (United States)

    Martel, Sylvain


    The vascular system in each human can be described as a 3D biomicrofluidic network providing a pathway close to approximately 100 000 km in length. Such network can be exploited to target any parts inside the human body with further accessibility through physiological spaces such as the interstitial microenvironments. This fact has triggered research initiatives towards the development of new medical tools in the form of microscopic robotic agents designed for surgical, therapeutic, imaging, or diagnostic applications. To push the technology further towards medical applications, nanotechnology including nanomedicine has been integrated with principles of robotics. This new field of research is known as medical nanorobotics. It has been particularly creative in recent years to make what was and often still considered science-fiction to offer concrete implementations with the potential to enhance significantly many actual medical practices. In such a global effort, two main strategic trends have emerged where artificial and synthetic implementations presently compete with swimming microorganisms being harnessed to act as medical nanorobotic agents. Recognizing the potentials of each approach, efforts to combine both towards the implementation of hybrid nanorobotic agents where functionalities are implemented using both artificial/synthetic and microorganism-based entities have also been initiated. Here, through the main eras of progressive developments in this field, the evolutionary path being described from some of the main historical achievements to recent technological innovations is extrapolated in an attempt to provide a perspective view on the future of medical nanorobotics capable of targeting any parts of the human body accessible through the vascular network.


    Directory of Open Access Journals (Sweden)

    Rodríguez Arocho Wanda


    Full Text Available Resumen:Este trabajo propone un examen crítico del concepto: “calidad educativa” desde la óptica históricocultural. A partir de la misma, se argumenta que la acepción técnica del concepto que domina el discurso educativo en la actualidad, según la cual la calidad se define a partir de parámetros derivados de una lógica empresarial, devela un origen asentado en el modelo neoliberal e impulsado por los procesos que caracterizan la globalización. Se plantea que tomar conciencia del origen sociocultural del concepto es una condición necesaria para construir significados alternos al término calidad y darle otros sentidos a su práctica. Se discute el rol que la pedagogía crítica puede desempeñar en la reflexión y la acción para el logro de esta meta.Abstract:This work presents a critical analysis of the concept of quality education from a cultural-historical perspective. It is argued that the technical reference of the concept that dominates current educational discourse, form which quality is defined in terms of parameters drawn form a commercial logical, unveils its origin grounded in the neoliberal model and propelled by the processes that characterize globalization. It is also argued that the development of consciousness regarding the sociocultural origins or the concept is a needed condition for the construction of alternative meanings and making new senses for its transformation into practices. The role of critical pedagogy in this endeavor is discussed.

  1. O brincar de uma criança autista sob a ótica da perspectiva histórico-cultural An autistic child's play from the cultural-historical perspective

    Directory of Open Access Journals (Sweden)

    Maria Fernanda Bagarollo


    historical-cultural perspective of human development - which conceives of subjects as social beings, culturally constituted in and through language - this statement is no longer sustainable, since play is a socially constituted activity. From this standpoint, this study aimed to analyze the peculiarities of play in a child with autism, immersed in rich experiences with other children, with toys and games. Data collection was carried out using video recordings of speech therapy sessions with a group of four autistic children. The focus was on one child's play activities (S1, four years. The recordings were transcribed and data was analyzed based on the microgenetic analysis perspective. The data showed that when autistic children experience positive social interactions, it is possible to develop play, imaginative processes and sequences of actions such as those observed in the group's social and cultural use of toys. We conclude that therapist intervention is critical during the interaction process, assigning meanings to the child's actions, enabling the possibility of constitution of cultural being and of interacting with others. This process helps build the basis for internalizations derived from playing with others. As observed, experiences outside the institution provided opportunities to play and develop during the process, albeit more slowly and more specifically.

  2. National Register Historic Districts (United States)

    Iowa State University GIS Support and Research Facility — The National Register Historic District layer is a shape file showing the boundaries of Historic Districts that are listed on the National Register of Historic Places.

  3. Paradigmenwechsel in der Anti-Aging-Medizin: Hormesis, Target-of-Rapamycin-Komplex und erste Anti-Aging-Pillen // Paradigm Shift in Anti-Aging Medicine: Hormesis, Target of Rapamycin Complex and First Human Anti-Aging-Pills

    Directory of Open Access Journals (Sweden)

    Römmler A


    dieser Gesellschaften. Manche Maßnahmen der Lebensführung (z. B. kalorienreduzierte Ernährung, regelmäßiges Training verbessern die Altersgesundheit, dennoch benötigen viele zusätzlich Therapien gegen Krankheiten im Alter. Deren größter Risikofaktor ist „das Altern“ selbst.brIn Tiermodellen können durch bestimmte Substanzen und Lebensführung die gesunde Lebensspanne verlängert und das Altern verzögert werden. Dies wird durch physiologische Signalketten vermittelt, die evolutionär konserviert erscheinen. Im Mittelpunkt solcher Regulatoren steht der mTOR-Komplex („mechanistic Target of Rapamycin“. Er verknüpft Signale wie Energie-, Nahrungs- und Stressstatus mit grundlegenden Aktivitäten der Zelle, zu denen Proliferation versus Zellarrest sowie Reparatur versus Apoptose gehören.brDie Zellregulation auf solche Signale bzw. Stressoren erfolgt nicht linear, sondern biphasisch (U-förmig, glockenförmig als hormetisches Prinzip. Demnach führen milde Stress-Dosen zunächst zur Aktivierung von Reparatursystemen, womit sich die Zelle an solche „giftigen“ Reize adaptiert und widerstandsfähiger wird. Erst bei höheren Reizen kommt es zum Umkehreffekt und zu toxischer Schädigung. „Hormesis“ beschreibt plausibel die in Modellorganismen beobachteten Anti-Aging-Effekte solcher milden Reize, die sich durch verlängerte Lebensspanne bei verminderter Krankheitsinzidenz (Diabetes mellitus, Karzinome, Demenz auszeichnen.brEinige natürliche mTOR-Inhibitoren sind für humane Anwendungen bereits verfügbar. Hierzu zählen Resveratrol, Rapamycin (Sirolimus und Metformin, die von Bakterien, Pilzen oder Pflanzen jeweils als „Giftstoffe“ zur Abwehr von Fressfeinden gebildet werden. Erste Humandaten bei Diabetikern unter Metformin und bei Älteren mit Immunseneszenz unter Rapamycin zeigen bereits Anti-Aging-Effekte, was neue Perspektiven für die Altersmedizin eröffnet.

  4. 道德历史人类学视域中我国多民族道德生活的历史变迁%Historical Changes of the Ethics in the Multi-ethnic Nation of China from the Perspective of Ethical Historical Anthropology

    Institute of Scientific and Technical Information of China (English)

    李伟; 陈文江


    It is a major turn in the orientation of the academic research on ethics and morality in China to probe into the occurrence and evolution of Chinese ethics,especially the great changes of the social ethics in modern times,from the perspective of the history of the ethics of multi-nation China.The changes of the paradigm has brought about changes in the subjects,content,topics,theoretical orien-tation,framework of analysis,and the research methodology,which have made the construction of the paradigm of the history of ethics in the multi-ethnic groups necessary and possible.By combining the empirical research of Anthropology and Sociology and the value analysis of Ethics,from the perspec-tives of daily lives,spiritual life and public intercourse life,the methodology studies the occurrence and the changes in core values,ethical culture and common spiritual home,thus forming a new theoretical analysis framework with empirical analysis dimension.From the perspective of this paradigm,the a-nalysis route of the historical changes of the ethics of Chinas multi-ethic groups can be examined as follows:the ethical origin of the concept of human beings in the ethics of the multi-ethnic nation;how the dharma of the human beings have been formed in the ethnic ethics;“where”the dharma of the hu-man beings have been formed in the ethnic ethics;the space of the presentation of dharma and the process of its social construction;and how the dharma has been spread and presented.%从多民族的道德生活史入手研究我国几千年文明史中伦理道德的发生演变,特别是近代以来社会道德伦理秩序的巨大变化,是我国伦理学研究方向的一个重大转变。这种研究范式把人类学、社会学的实证分析方法和伦理学的价值分析方法结合起来,从我国多民族的人的日常生活、精神生活以及公共交往生活三个层面,对多民族道德生活中的人的核心价值观念、伦理文化形态和共有精神

  5. Disciplinary Perspectives on Archaeoastronomy (United States)

    McCluskey, Stephen C.

    This chapter examines the contributions of major academic disciplines to archaeoastronomy, beginning with a consideration of several indicators of the participation of scholars from various fields. We then consider examples of research from astronomy and the physical sciences; anthropology, archaeology, and the social sciences; and the historical disciplines to see how they reflect their disciplinary perspectives. The questions drawn from these varied disciplinary perspectives stimulate different strands of research, enriching the study of astronomies in cultures.


    Directory of Open Access Journals (Sweden)

    Valentin Gabriel CRISTEA


    Full Text Available Henning Kirkegaard shows that the evolution of accounting is to shift from one paradigm to another . Business continuity perspective should guide the company into the future , without confine it exclusively in the past. Accounting in its classical form , however, can not be dissociated from the historical cost evaluation .

  7. Treatment of Tuberculosis. A Historical Perspective. (United States)

    Murray, John F; Schraufnagel, Dean E; Hopewell, Philip C


    Of all achievements in medicine, the successful treatment of tuberculosis has had one of the greatest impacts on society. Tuberculosis was a leading cause of disease and a mortal enemy of humanity for millennia. The first step in finding a cure was the discovery of the cause of tuberculosis by Robert Koch in 1882. The sanatorium movement that began shortly afterward in Europe, and soon spread to the United States, brought attention to the plight of afflicted persons, and catalyzed public health action. The antituberculosis benefit of streptomycin was announced in 1945, although application was limited by the rapid development of resistance. para-Aminosalicylic acid, also discovered in 1945, when combined with streptomycin was found to greatly reduce the occurrence of drug resistance. In 1952, isoniazid opened the modern era of treatment; it was inexpensive, well tolerated, and safe. In the early 1960s, ethambutol was shown to be effective and better tolerated than para-aminosalicylic acid, which it replaced. In the 1970s, rifampin found its place as a keystone in the therapy of tuberculosis. The use of rifampin enabled the course of treatment to be reduced to nine months. Incorporation of pyrazinamide into the first-line regimen led to a further reduction of treatment duration to six months. Treatment of multiple drug-resistant tuberculosis remains a difficult problem requiring lengthy treatment with toxic drugs. However, shortened regimens show promise, and two new drugs, bedaquiline and delamanid, have demonstrated effectiveness in preliminary studies and are being used for extensively drug-resistant tuberculosis.

  8. An historical review and perspective of AINSE

    Energy Technology Data Exchange (ETDEWEB)

    Ophel, T.R. [Australian National University, Canberra, ACT, (Australia). Department of Nuclear Physics


    Full text: ANSTO was formed in 1958 as a cooperative venture of modest scope, involving the newly established AAEC (created by the Atomic Energy Act of 1953 with facilities at Lucas Heights being formally opened in 1955) and the eight universities that existed at the time. Research emphasis was very much nuclear, with the two reactors MOATA and HIFAR and possible future nuclear energy developments defining it. Two accelerators, added in the early sixties - the 3 MV Van de Graaff and the 1.3 MV electron machine, were to sustain those original activities of the AAEC. It would probably be true to say that AINSE in those early days placed much importance on the general support of nuclear science throughout Australia, whereas now of course the facilitation of the use of ANSTO facilities has become the main function. Thereafter, both AINSE and the AAEC have undergone dramatic change. The number of universities expanded to 19 in the late sixties, along with more support and encouragement for research at both the new institutions and the original group of eight. University use of Lucas Heights facilities, through the agency of AINSE, expanded and began to diversify somewhat into other disciplines - a trend that has continued apace ever since. In the nineties, the Dawkins revolution led to a doubling of the number of tertiary institutions, so that once again AINSE experienced a quantum jump in size, with of course matching complexity. In parallel, AAEC broadened its activities to embrace a wide range of nuclear and energy related areas, though basic research began to taper off. Finally, the organization was given a new charter in 1985 and re-named ANSTO. A much expanded university system, the `new` ANSTO, the rise of economic rationalism and the creation of the Australian Research Council have combined to provide a succession of challenges to AINSE. From the original small, club-like beginning with narrow interests, AINSE has emerged with more than a four-fold increase in membership, to foster research within almost all of the Faculties of those members

  9. The Moro Problem: An Historical Perspective (United States)


    system to allow for three annual. harvests. "The major crops that are raised for profit are copra, coffee, abaca , and fruit. Copra production was... abaca is usually sold to Chinese middlemen who are .on Jolo Island. The method of fishing utilized by the Tausug employs motorized boats in offshore

  10. Typography in Media Historical Perspective. An Introduction

    NARCIS (Netherlands)

    Post, Jack; Lentjes, Ewan


    textabstractEditorialAt first glance, a special issue on the subject of typography might seem an unusual choice for an academic journal dedicated to media history. After all, wouldn’t the study of typography be better suited to a publication on the history of art and graphic design, or perhaps the s

  11. Foreign Language Learning Difficulties: An Historical Perspective. (United States)

    Ganschow, Leonore; Sparks, Richard L.; Javorsky, James


    Discusses cognitive, affective, and linguistic influences on foreign language learning. It proposes the Linguistic Coding Differences Hypothesis (LCDH) model for understanding foreign language learning problems. The empirical support for the LCDH model is reviewed. Diagnostic, pedagogical, and policy implications are addressed. (Author/DB)

  12. Earth cycles:A historical perspective

    Institute of Scientific and Technical Information of China (English)

    David Oldroyd


    @@ For at Jeast two centuries,most geologists have been convinced that Earth has experienced a"linear,"directional history.There iS no doubt that our planet is very different from what it was a few billion years ago.

  13. Historical perspective of living donor liver transplantation

    Institute of Scientific and Technical Information of China (English)

    See Ching Chan; Sheung Tat Fan


    Living donor liver transplantation (LDLT) has gone through its formative years and established as a legitimate treatment when a deceased donor liver graft is not timely or simply not available at all. Nevertheless,LDLT is characterized by its technical complexity and ethical controversy. These are the consequences of a single organ having to serve two subjects, the donor and the recipient, instantaneously. The transplant community has a common ground on assuring donor safety while achieving predictable recipient success. With this background, a reflection of the development of LDLT may be appropriate to direct future research and patient- care efforts on this life-saving treatment alternative.

  14. Einstein and General Relativity: Historical Perspectives. (United States)

    Chandrasekhar, S.


    This paper presented in the 1978 Oppenheimer Memorial Lecture at Los Alamos Scientific Laboratories on August 17, 1978, discusses Einstein's contributions to physics, in particular, his discovery of the general theory of relativity. (HM)

  15. [Historical perspective of mass spectrometry in microbiology]. (United States)

    Mingorance, Jesús; Regueiro, Benito; Muñoz-Bellido, Juan Luis


    La espectrometría de masas (EM) es una técnica de análisis que permite caracterizar muestras midiendo las masas (estrictamente las razones masa-carga) de las moléculas componentes. Cuenta con más de un siglo de historia y evolución tecnológica y a lo largo de los años ha ampliado su alcance desde los isótopos a moléculas pequeñas, moléculas orgánicas más complejas y, en las últimas décadas, macromoléculas (ácidos nucleicos y proteínas). La EM MALDI-TOF (matrix-assisted laser desorption ionization time-of-flight) es una variante que permite el análisis de mezclas complejas de proteínas y que se ha aplicado recientemente a la identificación de microorganismos en cultivo, convirtiéndose en una herramienta rápida y eficaz para el diagnóstico microbiológico que ha conseguido entrar en poco tiempo en la rutina de muchos servicios de microbiología clínica. El gran impacto que ha tenido está impulsando el desarrollo de nuevas aplicaciones en el campo de la microbiología clínica.

  16. Nordic food culture – A historical perspective


    Amilien, Virginie


    Henry Notaker is a well- known Norwegian historian, specialist of books and articles about food, culture and history. He has got awards for journalism on food history, he was responsible for TV series about food and history in the 1990’s, and he is currently teaching in food history at the universities in Bergen and Agder and at Akershus University College (courses on food culture). Henry Notaker is a member of the editorial board of the scientific journal Food & History. He has published alm...

  17. WMD Forecasting in Historical and Contemporary Perspective (United States)


    missile was developed by stacking the shorter range liquid fueled Prithvi on top of a solid rocket booster thought to have come from India’s developing... booster in an ICBM development. Acquisition patterns/trends Even as the dispersion of biotechnology promises a means of improving the quality of...argues that BW provide “more bang for the buck ,” they are cheap to make and easy to deliver. 2) Economically and technically attractive. That is

  18. Neurology Of Hysteria - A Historical Perspective

    Directory of Open Access Journals (Sweden)

    Chakravarty Ambar


    Full Text Available The Present article summarises the changing concepts about hysteria from Egyptian papyrus to early 20th century. The contributions of early physicians including Charcot and his pupils in developing bedside clinical methods to differentiate organic disease from hysterical conversion have been highlighted. Various forms of therapy used over several centuries for this fascinating disorder is also discussed.

  19. Historical perspectives on fatty acid chemistry (United States)

    Fatty acids are basic renewable chemical building blocks that can be used as intermediates for a multitude of products. Today the global value of fatty acids exceeds 18 billion dollars and is expected to increase to nearly 26 billion over the period from 2014-2019. From it auspicious beginnings, the...

  20. Phonology and Language: A Historical Perspective (United States)

    Arezzo, Emilia La Pergola


    This article first gives the definition of "phonology" most widely accepted today, and then illustrates briefly the role that phonology has had in the works of European and American linguists, such as De Saussure, Trubetckoj, Sapir, Bloomfield, H. Sweet, D. Jones, O. Jesperson, K. Pike, Trager and Smith, and N. Chomsky. (CFM)

  1. Rocks From Space: A Historical Perspective (United States)

    Yeomans, Donald K.


    The notion that rocks could fall to Earth from space was not seriously considered until the early nineteenth century. The impact origin of the lunar craters reached a scientific consensus only in the mid twentieth century and a wide understanding that the Earth’s neighborhood is crowded with millions of near-Earth asteroids that could cause impact damage to Earth is less than a few decades old. In the late seventeenth century, even such notable scientists as Robert Hooke and Isaac Newton ruled out the existence of small bodies in space. In 1794, the German physicist and father of acoustics Ernst F.F. Chladni published a short list of fireball events and effectively argued that these events and the meteorites they dropped could not have been atmospheric and were likely due to cosmic rocks entering the Earth’s atmosphere. In 1802 the British chemist Edward Charles Howard showed that several meteoritic stones had similar chemical compositions and that nickel, which is seldom present in terrestrial rocks except in trace amounts, was common to all of them. These two pivotal works, along with a number of early nineteenth century falls, slowly strengthened the notion that fireball events and the stones they dropped were of celestial, rather than atmospheric, origin. Even so, it was well into the mid twentieth century before Meteor Crater in particular and the obvious lunar craters in general were widely considered as impact phenomena rather than being due to volcanic eruptions or steam generated explosions. It seems that despite Mother Nature’s best attempts to point out the importance of impact events in the solar system and the existence of a vast population of near-Earth asteroids, much of the scientific community reached these viewpoints rather late. Likely reasons for this slow acceptance of rocks from space will be discussed.

  2. Hangman's fracture: a historical and biomechanical perspective. (United States)

    Rayes, Mahmoud; Mittal, Monika; Rengachary, Setti S; Mittal, Sandeep


    The execution technique of hanging, introduced by the Angle, Saxon, and Jute Germanic tribes during their invasions of the Roman Empire and Britain in the 5th century, has remained largely unchanged over time. The earliest form of a gallows was a tree on which prisoners were hanged. Despite the introduction of several modifications such as a trap door, the main mechanism of death remained asphyxiation. This created the opportunity for attempted revival after the execution, and indeed several well-known cases of survival following judicial hanging have been reported. It was not until the introduction of the standard drop by Dr. Samuel Haughton in 1866, and the so-called long drop by William Marwood in 1872 that hanging became a standard, humane means to achieve instantaneous death. Hangmen, however, fearing knot slippage, started substituting the subaural knot for the traditional submental knot. Subaural knots were not as effective, and cases of decapitation were recorded. Standardization of the long drop was further propagated by John Berry, an executioner who used mathematical calculations to estimate the correct drop length for each individual to be hanged. A British committee on capital sentences, led by Lord Aberdare, studied the execution method, and advocated for the submental knot. However, it was not until Frederic Wood-Jones published his seminal work in 1913 that cervical fractures were identified as the main mechanism of death following hanging in which the long drop and a submental knot were used. Schneider introduced the term "hangman's fracture" in 1965, and reported on the biomechanics and other similarities of the cervical fractures seen following judicial hangings and those caused by motor vehicle accidents.

  3. A historical perspective on Modified Newtonian Dynamics

    CERN Document Server

    Sanders, R H


    I review the history and development of Modified Newtonian Dynamics (MOND) beginning with the phenomenological basis as it existed in the early 1980s. I consider Milgrom's papers of 1983 introducing the idea and its consequences for galaxies and galaxy groups, as well as the initial reactions, both negative and positive. The early criticisms were primarily on matters of principle, such as the absence of conservation laws and perceived cosmological problems; an important step in addressing these issues was the development of the Lagrangian-based non-relativistic theory of Bekenstein and Milgrom. This theory led to the development of a tentative relativistic theory that formed the basis for later multi-field theories of gravity. On an empirical level the predictive success of the idea with respect to the phenomenology of galaxies presents considerable challenges for cold dark matter. For MOND the essential challenge remains the absence of a generally accepted theoretical underpinning of the idea and, thus, cosm...

  4. The Stress Reaction: A Historical Perspective. (United States)

    Rom, Oren; Reznick, Abraham Z


    The history of stress research - milestones and people. Definitions and modern concepts of stress as well as the conflict between Hans Selye and the psychologists are described in this review. The molecular and physiological mechanisms of stress and their possible pharmacological intervention are introduced. The cycle of stress is presented as a new concept of the stress reaction, trying to bridge the gap between physiology and psychology. The cycle is a circular event in life, composed of 4 phases: (1) the resting ground phase, (2) the tension phase, (3) the response phase, and (4) the relief phase. In each phase, both physiological and psychological components can be assessed. These components are the basis for the proper handling of each phase and provide a unified model for the psycho-biological response to stress. In addition, parameters of the cycle such as frequency, duration, and intensity can be measured, providing an effective tool for stress management. Finally, modern techniques and mechanisms for coping with stress are discussed like the Norwegian Gate Theory and Lazarus Dichotomy Model for the Stress Reaction. In the above models, specific examples of how people respond to the first time encounter of stressful events and how soldiers cope with stress are presented.

  5. The Intelligence Revolution: A Historical Perspective (United States)


    coreligionists across the border was no more than a prudent insurance policy. 4 8 Catholic and Protestant, the Reformations made resistance legitimate, but not...scouts, including Redmond Burke, Will Farley , Charles Dabney, John S. Mosby, and Frank Stringfellow. 41 Scouts performed diverse functions. At times...34Razvedka" [Intelligence (reconnaissance)], Sovetskaia voennaia entsiklopediia [Soviet Military Encyclopedia ], 8 vols., (Moscow: Voenizdat, 1976-1980

  6. Constructing Worlds of Education: A Historical Perspective (United States)

    Droux, Joëlle; Hofstetter, Rita


    Over the past two decades, historians have dedicated a growing amount of research to the history of globalization. This introduction shows how the articles in this issue contribute to this dynamic, aiming to illustrate its heuristic potential in historicizing educational phenomena. The field of education is presented as a relevant platform for an…

  7. Historical perspective on the use of garlic. (United States)

    Rivlin, R S


    The objective of this review is to examine briefly the medical uses of garlic throughout the ages and the role that it was considered to play in prevention and treatment of disease. Interest in the potential benefits of garlic has origins in antiquity and is one of the earliest documented examples of plants employed for treatment of disease and maintenance of health. Garlic was in use at the beginning of recorded history and was found in Egyptian pyramids and ancient Greek temples. There are Biblical references to garlic. Ancient medical texts from Egypt, Greece, Rome, China and India each prescribed medical applications for garlic. In many cultures, garlic was administered to provide strength and increase work capacity for laborers. Hippocrates, the revered physician, prescribed garlic for a variety of conditions. Garlic was given to the original Olympic athletes in Greece, as perhaps one of the earliest "performance enhancing" agents. It is of interest that cultures that developed without contact with one another came to similar conclusions about the efficacy of garlic. Modern science is tending to confirm many of the beliefs of ancient cultures regarding garlic, defining mechanisms of action and exploring garlic's potential for disease prevention and treatment.

  8. Drug misuse in sport: a historical perspective. (United States)

    Gerrard, David


    This editorial draws comparisons between the recent revelations of drug misuse in Russian sport, and the State-sponsored programme of the former German Democratic Republic. While 50 years separates these two regimes, there are commonalities. The history of major incidents involving drug abuse by serious national players in sport suggests a 20-year cycle, with the GDR, China and now Russia employing similar strategies. These events underscore the value placed upon international sporting success by politicians.

  9. The uses of neutrinos: a historical perspective

    Energy Technology Data Exchange (ETDEWEB)

    Mateos, G [Centro de Estudios Interdisciplinarios en Ciencias Y Humanidades, Universidad Autonoma Nacional de Mexico, Mexico (Mexico); Navarro, J [Department of History and Philosophy of Science, University of Cambridge, Free School Lane, Cambridge, CB2 3RH (United Kingdom)


    When Pauli postulated the existence of a new elementary particle, the 'neutron', in the late 1930s, he was introducing an entity to fill the gaps in the physics of the day. There was no direct evidence for such a particle; only the need to account for the missing energy in beta decay processes and to explain the statistics of some nuclei. Thus, Pauli's neutron was called into existence to solve problems in the areas of radioactivity and nuclear physics; but, in time, it would prove useful in many other areas of physics. The aim of this paper is to describe the many uses the neutrino has had in physics since its appearance, uses that have determined the ontological status of this elusive particle. Interestingly, the experimental detection of neutrinos 50 years ago was a minor episode in understanding the nature of such particles. As we shall argue, other moments in the biography of the particle proved more significant in determining the uses of neutrinos and their ontology.

  10. Historical Perspectives: plasticity of mammalian skeletal muscle. (United States)

    Pette, D


    More than 40 years ago, the nerve cross-union experiment of Buller, Eccles, and Eccles provided compelling evidence for the essential role of innervation in determining the properties of mammalian skeletal muscle fibers. Moreover, this experiment revealed that terminally differentiated muscle fibers are not inalterable but are highly versatile entities capable of changing their phenotype from fast to slow or slow to fast. With the use of various experimental models, numerous studies have since confirmed and extended the notion of muscle plasticity. Together, these studies demonstrated that motoneuron-specific impulse patterns, neuromuscular activity, and mechanical loading play important roles in both the maintenance and transition of muscle fiber phenotypes. Depending on the type, intensity, and duration of changes in any of these factors, muscle fibers adjust their phenotype to meet the altered functional demands. Fiber-type transitions resulting from multiple qualitative and quantitative changes in gene expression occur sequentially in a regular order within a spectrum of pure and hybrid fiber types.

  11. [Therapy of scoliosis from a historical perspective]. (United States)

    Harms, J; Rauschmann, M; Rickert, M


    Scoliosis can be considered as one of the classical orthopedic diseases of the spine. The history of orthopedics is closely connected to the development of the therapy of scoliosis. In the eighteenth and the beginning of the nineteenth centuries the therapy of scoliosis was mainly a conservative corrective orthopedic treatment with a variety of corset forms and extension bed treatment. In the middle of the nineteenth century physiotherapy (movement therapy) became established as an supplementary active treatment. The first operations for treatment of scoliosis were carried out in 1839. The real success with surgical procedures for improvement in corrective options was connected to the introduction of metal spinal implants in the early 1960s.

  12. Nelson syndrome: historical perspectives and current concepts. (United States)

    Hornyak, Mark; Weiss, Martin H; Nelson, Don H; Couldwell, William T


    The appearance of an adrenocorticotropic hormone (ACTH)-producing tumor after bilateral adrenalectomy for Cushing disease was first described by Nelson in 1958. The syndrome that now bears his name was characterized by hyperpigmentation, a sellar mass, and increased plasma ACTH levels. The treatment of Cushing disease has changed drastically since the 1950s, when the choice was adrenalectomy. Thus, the occurrence, diagnosis, and treatment of Nelson syndrome have changed as well. In the modern era of high-resolution neuroimaging, transsphenoidal microneurosurgery, and stereotactic radiosurgery, Nelson syndrome has become a rare entity. The authors describe the history of the diagnosis and treatment of Nelson syndrome. In light of the changes described, the authors believe this disease must be reevaluated in the contemporary era and a modern paradigm adopted.

  13. Understanding Electronic Commerce from a historical perspective


    Heng, S.H.


    The aim of this paper is to examine the macro-level phenomena associated with electronic commerce (EC), and it is mainly being informed by a study of the history of commerce. Commerce in its modem form first appeared in early 13th century in Italy where the political conditions were conducive for it. Trade facilitated the exchange of goods, thereby enhancing the efficiency between production and consumption. Even more important than this was its role in the creation of many modem business pra...

  14. A Historical Perspective of the Paralympic Games (United States)

    DePauw, Karen P.


    Athletes with disabilities are more visible in the 21st century than they used to be, including in the world of sport. Today, one hears about the Paralympic Games, can find media coverage of them, can read about athletes who compete in the Paralympics and about advancements in sport prosthetic devices in science and sport magazines, and can even…

  15. An historical perspective on GABAergic drugs. (United States)

    Froestl, Wolfgang


    In 1950, γ-aminobutyric acid (GABA) was discovered in the brain and in 1967 it was recognized as an inhibitory neurotransmitter. The discovery of the benzodiazepines Librium® (launched in 1960) and Valium® by Sternbach initiated huge research activities resulting in 50 marketed drugs. In 1975, Haefely found that GABA is involved in the actions of benzodiazepines. The baclofen-sensitive, bicuculline-insensitive GABA(B) receptor was discovered by Bowery in 1980, and the baclofen-insensitive, bicuculline-insensitive GABA(C) receptor by Johnston in 1984. Barnard & Seeburg reported the cloning of the GABA(A) receptor in 1987, Cutting the GABA(C) receptor in 1991 and Bettler the GABA(B1a) and GABA(B1b) receptors in 1997. Six groups cloned the GABA(B2) receptor in 1998/1999 showing that the GABA(B) receptor functions as a heterodimer with GABA(B1b)/GABA(B2) mediating postsynaptic inhibition and GABA(B1a)/GABA(B2) mediating presynaptic inhibition. Möhler and McKernan dissected the pharmacology of the benzodiazepine-receptor subtypes. Antagonists and positive allosteric modulators of GABA(B) receptors were discovered in 1987 and 2001, respectively. GABA transporter inhibitor, tiagabine, was launched in 1996, a GABA aminotransferase inhibitor, vigabatrin, in 1998 and a glutamic acid decarboxylase activator, pregabalin, in 2004. Most recently, brain-penetrating GABA(C)-receptor antagonists were reported in 2009.

  16. Forces in Physics A Historical Perspective

    CERN Document Server

    Shore, Steven N


    Force is one of the most elementary concepts that must be understood in order to understand modern science; it is discussed extensively in textbooks at all levels and is a requirement in most science guidelines. It is also one of the most challenging - how could one idea be involved in such disparate physical phenomena as gravity and radioactivity? Forces in Physics helps the science student by explaining how these ideas originally were developed and provides context to the stunning conclusions that scientists over the centuries have arrived at. It covers the history of all of the four traditi

  17. Heat and smoke - a historical perspective

    Energy Technology Data Exchange (ETDEWEB)

    Hester, C. [SIMTARS, Redbank, Qld. (Australia)


    From 1891 until 1947 coal was used to fire the boiler at the water supply pumping station at Mount Crosby, near Ipswich in south-east Queensland. Ash and waste coal was tipped over the nearest bank which lay between the boiler house and the Brisbane River. By 1947 thousands of tonnes of hot waste had been ejected, covered with a meagre amount of soil, and forgotten. In 1953 the river began to rise in an extensive flow that its 4000 square mile catchment periodically caused, and water sped over the earth fill. A portion of the bank collapsed into the water and when it did, there was a huge and continuing efflux of steam from the ash and coal waste, which had remained heated for as long as 60 years. The possibility of a water gas reaction having caused this 'explosion' cannot be ruled out. This incident gives an indication of the lasting problems associated with discarded coal waste; and the fact that these problem rarely go away of their own accord. Readers interested in details of heat stress or requiring information on compliance monitoring related to the EPA Environmental Protection (Air) Policy are referred to the Queensland Government's Environment and Chemistry Centre. 3 photos.

  18. Amyotrophic Lateral Sclerosis: A Historical Perspective. (United States)

    Katz, Jonathan S; Dimachkie, Mazen M; Barohn, Richard J


    This article looks back in time to see where the foundational basis for the understanding of amyotrophic lateral sclerosis originated. This foundation was created primarily in France by Jean-Martin Charcot and his fellow countrymen and disciples, along with key contributions from early clinicians in England and Germany. The early work on amyotrophic lateral sclerosis provides a useful foundation for today's clinicians with respect to tying together genetic and biologic aspects of the disorder that have been discovered over the past few decades.

  19. Discovery of anticoagulant drugs: a historical perspective. (United States)

    Gómez-Outes, Antonio; Suárez-Gea, Ma Luisa; Calvo-Rojas, Gonzalo; Lecumberri, Ramón; Rocha, Eduardo; Pozo-Hernández, Carmen; Terleira-Fernández, Ana Isabel; Vargas-Castrillón, Emilio


    The history of the traditional anticoagulants is marked by both perseverance and serendipity. The anticoagulant effect of heparin was discovered by McLean in 1915, while he was searching for a procoagulant in dog liver. Link identified dicumarol from spoiled sweet clover hay in 1939 as the causal agent of the sweet clover disease, a hemorrhagic disorder in cattle. Hirudin extracts from the medicinal leech were first used for parenteral anticoagulation in the clinic in 1909, but their use was limited due to adverse effects and difficulties in achieving highly purified extracts. Heparins and coumarins (i.e.: warfarin, phenprocoumon, acenocoumarol) have been the mainstay of anticoagulant therapy for more than 60 years. Over the past decades, the drug discovery paradigm has shifted toward rational design following a target-based approach, in which specific proteins, or "targets", are chosen on current understandings of pathophysiology, small molecules that inhibit the target's activity may be identified by high-throughput screening and, in selected cases, these new molecules can be developed further as drugs. Despite the application of rational design, serendipity has still played a significant role in some of the new discoveries. This review will focus on the discovery of the main anticoagulant drugs in current clinical use, like unfractionated heparin, low-molecular-weight heparins, fondaparinux, coumarins (i.e.: warfarin, acenocoumarol, phenprocoumon), parenteral direct thrombin inhibitors (DTIs) (i.e.: argatroban, recombinant hirudins, bivalirudin), oral DTIs (i.e.: dabigatran) and oral direct factor Xa inhibitors (i.e.: rivaroxaban, apixaban).

  20. A Historical Perspective on Light Infantry (United States)


    runners and signals. (Sometimes, battalion and company commanders enjoyed the use nf captured U.S. walkie-talkies.) Under these conditions, unyielding...concealed, The patrol element that discovered the CT@ kept the camp under surveillance and sent off a runner to inform the platoon leader or company...through a sparsely settled and thinly held maze of barren hills and ridges. German opposition consisted of scattered outposts leading back to a main line of

  1. The ligament augmentation device: an historical perspective. (United States)

    Kumar, K; Maffulli, N


    Anterior cruciate ligament (ACL) injury is the most common ligament injury in the knee, and a significant number of patients may develop progressive instability and disability despite aggressive rehabilitation. Various materials have been used for its reconstruction. These include autografts, allografts, prosthetic ligaments, and synthetic augmentation of the biological tissue. The concept of ligament augmentation device (LAD) arose from the observation that biological grafts undergo a phase of degeneration and loss of strength before being incorporated. The LAD is meant to protect the biological graft during this vulnerable phase. However, it provokes an inflammatory reaction in the knee, and has been found to delay maturation of autogenous graft in humans. In experimental situations, the LAD has been found to share loads in a composite graft. It has also been found to be substantially stronger than the biological graft. However, in clinical situations no significant advantages have been observed with the use of LAD to augment patellar tendon or hamstring reconstruction of the chronic ACL-deficient knee or in the acute setting to augment repair of the torn ACL. There are very few reports of the use of LAD in reconstruction of the posterior cruciate ligament, and again these do not suggest any advantage in its use. Insertion of the LAD implies the introduction of a foreign material into the knee, has been associated with complications such as reactive synovitis and effusions, and may also be associated with an increased risk of infection. At present, there is no evidence that its routine use should be advocated in uncomplicated reconstructions of the ACL using biological grafts.

  2. Typography in Media Historical Perspective. An Introduction

    NARCIS (Netherlands)

    Post, Jack; Lentjes, Ewan


    abstractEditorialAt first glance, a special issue on the subject of typography might seem an unusual choice for an academic journal dedicated to media history. After all, wouldn’t the study of typography be better suited to a publication on the history of art and graphic design, or perhaps the study

  3. A Historical Perspective of Medical Education (United States)

    Balcioglu, Huseyin; Bilge, Ugur; Unluoglu, Ilhami


    Even though there are significant developments in recent years in medical education, physicians are still needed reform and innovation in order to prepare the information society. The spots in the forefront of medical education in recent years; holistic approach in all processes, including health education, evidence-based medicine and…

  4. Physics and medicine: a historical perspective. (United States)

    Keevil, Stephen F


    Nowadays, the term medical physics usually refers to the work of physicists employed in hospitals, who are concerned mainly with medical applications of radiation, diagnostic imaging, and clinical measurement. This involvement in clinical work began barely 100 years ago, but the relation between physics and medicine has a much longer history. In this report, I have traced this history from the earliest recorded period, when physical agents such as heat and light began to be used to diagnose and treat disease. Later, great polymaths such as Leonardo da Vinci and Alhazen used physical principles to begin the quest to understand the function of the body. After the scientific revolution in the 17th century, early medical physicists developed a purely mechanistic approach to physiology, whereas others applied ideas derived from physics in an effort to comprehend the nature of life itself. These early investigations led directly to the development of specialties such as electrophysiology, biomechanics, and ophthalmology. Physics-based medical technology developed rapidly during the 19th century, but it was the revolutionary discoveries about radiation and radioactivity at the end of the century that ushered in a new era of radiation-based medical diagnosis and treatment, thereby giving rise to the modern medical physics profession. Subsequent developments in imaging in particular have revolutionised the practice of medicine. We now stand on the brink of a new revolution in post-genomic personalised medicine, with physics-based techniques again at the forefront. As before, these techniques are often the unpredictable fruits of earlier investment in basic physics research.

  5. Historical Perspectives: The 1958 Conference Report (United States)

    Jolly, Jennifer L.


    From February 6 to 8, 1958, approximately 200 educators and interested individuals were invited to New York City in hopes of discussing the education of academically talented students at the secondary level. Topics included identification, programming options, the social emotional well-being of students, and the limited resources allocated to…

  6. Planetary geomorphology: Some historical/analytical perspectives (United States)

    Baker, V. R.


    Three broad themes from the history of planetary geomorphology provide lessons in regard to the logic (valid reasoning processes) for the doing of that science. The long controversy over the origin of lunar craters, which was dominated for three centuries by the volcanic hypothesis, provides examples of reasoning on the basis of authority and a priori presumptions. Percival Lowell's controversy with geologists over the nature of linear markings on the surface of Mars illustrates the role of tenacity in regard to the beliefs of some individual scientists. Finally, modern controversies over the role of water in shaping the surface of Mars illustrate how the a priori method, i.e., belief produced according to reason, can seductively cloud the scientific openness to the importance of brute facts that deviate from a prevailing paradigm.

  7. Emigrants and Emigration States in Historical Perspective


    Waldinger, Roger


    International migration from poorer to richer states gives emigrants resources that they can use to exercise leverage over home states, but also leaves them vulnerable to exploitation and discrimination in host states, conditions that activate interventions by emigration states seeking to influence and protect nationals abroad.  This paper traces the changing patterns of interaction between emigrants and emigration states over the past century and a half.  Many of the underlying incentives fo...

  8. Emigrants and Emigration in Historical Perspective


    Waldinger, Roger


    International migration from poorer to richer states gives emigrants resources that they can use to exercise leverage over home states, but also leaves them vulnerable to exploitation and discrimination in host states, conditions that activate interventions by emigration states seeking to influence and protect nationals abroad.  This paper traces the changing patterns of interaction between emigrants and emigration states over the past century and a half.  Many of the underlying incentives fo...

  9. Mangghuer Folktales and Historical Narratives

    Directory of Open Access Journals (Sweden)

    Grigori Potanin


    Full Text Available Grigori Potanin (Xénia de Heering, translator. 2015. Mangghuer Folktales and Historical Narratives IN Gerald Roche and CK Stuart (eds Asian Highlands Perspectives 36: Mapping the Monguor, 178-188, 301-332. Eleven folktales and historical narratives are presented that were collected by Grigori Potanin during his visit to the Sanchuan Region in 1884-1885. The folktales all appear to have been collected from males, mostly monks. One folktale deals with Wencheng Gongzhu, the Chinese bride of the Tibetan emperor, Srong btsan sgam po. One deals with the building of the Potala Palace in Lha sa, another with the founder of Dge lugs Buddhism, Tsong kha pa, and two more with the founding of Dmar gtsang Monastery, in A mdo. Two narratives relate events from the Chinese epic, Journey to the West, and four narrate events related to Li Jinwang, a Tang Dynasty general, and his adopted son, Li Cunxiao.

  10. Governmentality as a Genealogical Toolbox in Historical Analysis (United States)

    Andersson, Janicke


    The aim of this article is to show how governmentality may be used to analyze historical events and discourses, and how this historical analysis can be used as a perspective to problematize contemporary discourses. The example used in this article is from my research on life-extension handbooks published in Sweden 1700-1930, and by this I stress…

  11. O corpo problematizado de uma perspectiva histórico-política El cuerpo problematizado de una perspectiva histórico-política The problematized body from a political-historical perspective

    Directory of Open Access Journals (Sweden)

    Kleber Prado Filho


    Full Text Available Este artigo trata da produção histórico-política dos corpos dos indivíduos nas sociedades ocidentais modernas, perspectiva mais próxima das ciências sociais e humanas, que é diversa e crítica da clássica abordagem anatômico-fisiológica predominante no domínio das ciências naturais e da medicina. Esta reflexão, apoiada no pensamento de Michel Foucault, busca desnaturalizar uma abordagem do corpo centrada em seus elementos biológicos e anatomofisiológicos, para problematizar a sua construção em termos sociais, econômicos e políticos, além de estéticos, ao longo da história.Este artículo trata de la producción histórico-política de los cuerpos de los individuos en las sociedades occidentales modernas, perspectiva más próxima de las ciencias sociales y humanas, que es diversa y crítica del clásico abordaje anatómico-fisiológico predominante en el dominio de las ciencias naturales y de la medicina. Esta reflexión, apoyada en el pensamiento de Michel Foucault, busca desnaturalizar un abordaje del cuerpo centrado en sus elementos biológicos y anatomofisiológicos, para problematizar su construcción en términos sociales, económicos y políticos, además de estéticos, a lo largo de la historia.The bodies' historical and political production in individuals in modern Western societies is provided. Whereas above perspective is closer to the social and human sciences, it is different and critical to the anatomical and physiological approach predominant in the natural sciences and in medicine. Current analysis, based on Michel Foucault, denaturalizes an approach of the body centered on biological and anatomical-physiological elements and problematizes its construction in social, economical and political terms, besides aesthetical ones, throughout History.

  12. A historical perspective and prospects of biomedical research on parasitic diseases Uma perspectiva histórica e prospecções da pesquisa biomédica em doenças parasitárias

    Directory of Open Access Journals (Sweden)



    Full Text Available We all hope that biotechnology will answer some social and economical unavoidable requirements of the modern life. It is necessary to improve agriculture production, food abundance and health quality in a sustainable development. It is indeed a hard task to keep the progress on taking into account the rational use of genetic resources and the conservation of biodiversity. In this context, a historical perspective and prospects of the biomedical research on parasitic diseases is described in a view of three generations of investigators. This work begins with a picture of the scientific progress on biomedical research and human health over the last centuries. This black-and-white picture is painted by dissecting current advancements of molecular biology and modern genetics, which are outlined at the meaning of prospecting achievements in health science for this new millenium.Espera-se que os grandes avanços da pesquisa de genomas alcancem saltos visíveis para a sobrevivência da humanidade dentro do contexto de sustentabilidade global. Vemos atualmente a necessidade imediata de incrementar a produção de alimentos e melhorar a qualidade de vida e saúde humana, mantendo a biodiversidade preservada. A biotecnologia é a utilização racional das ferramentas geradas pela biologia molecular e genética moderna que, dado ao grande avanço dessas áreas, poderá em breve responder essas novas questões. Este trabalho, escrito por três gerações de pesquisadores, inicia com uma perspectiva histórica da pesquisa biomédica em doenças parasitárias nos últimos séculos em nosso país. Em seguida, descrevemos os mais recentes avanços da biologia molecular e genética genômica. Ressaltamos a importância dessas novas conquistas dentro de uma prospecção da pesquisa biomédica deste século e seus possíveis impactos na saúde humana.

  13. 历史唯物主义视野中的中国正义问题%The Issue of Justice in China from the Perspective of Historical Materialism

    Institute of Scientific and Technical Information of China (English)



    当代中国的正义问题涉及三个子问题:(1)我们应该追求什么样的正义?(2)对于分配正义,我们最需要关注什么?(3)我们应该如何看待正义批判?从历史唯物主义的视角看,中国所要追求的正义应是崇尚契约精神与人的内在价值的正义;与其关注分配正义本身,不如关注制约分配正义的权力和市场等背景因素,因为正是这些因素制约着分配正义的产生及其实现;正义批判虽然属于意识形态批判,但它对于当代中国的制度完善与社会进步有着独特的价值。%From the Perspective of Historical Materialism, three questions about the issue of justice in contemporary China are examined in this paper: (1) What kind of justice should we pursue? (2) For distributive justice, what do we need to concern about? (3) How to look at the critique of justice? The contemporary China should pursue the justice which emphasizes contractual spirit and the intrinsic val- ue of human. It is important to pay more attention to the background factors of distributive justice such as the elements of the public power and the market behind it than to the distributive justice itself, for the key of solving the distributive justice in China lies in solving the background factors such as the elements of the public power and the market. Although the critique of justice is subject to the critique of ideology, it is helpful for the development of social institution and social progress in China with distinctive value.

  14. 基于空间生产视角的历史街区改造困境--以汕头小公园历史街区为例%The Dilemma of Historic District Reconstruction Based on the Perspective of Space Production:A Case Study of Small Park Historic District of Shantou

    Institute of Scientific and Technical Information of China (English)

    袁奇峰; 蔡天抒


    Small Park Historic District in Shantou is the result of urbanization under the joint efforts of Chaoshan overseas wage economy relfux and foreign investment in the early 20th century. With the city center drift, its commercial monopoly has been losing, and physical structure and social structure bidirectional are aging. Housing property fragmentation and expected earnings instability has made the space production of local ifnance and capital markets tend to the new district with lower transaction costs, but the old town is locked to the negative cycle. From improving living conditions to pursuing urban land revenue, Small Park District has gone through three stages of transformation: "must attack" type of house reconstruction, "into a iflm supporting" type of residential groups Construction and "major demolition and construction" type of space production. Finally the achievement effect is ift to market interests, so that Small Park District renovation under the auspices of the right and capital has become urban development activities with land beneift as the goal. This article, from the perspective of protective development dilemma of Small Park Historic District, discusses the deep contradictions between protection plan expected and the game of actual development.%汕头小公园历史街区是20世纪初潮汕华侨打工经济回流与外商投资共同推动城市化的结果。随着城市中心漂移,其商业垄断地位渐失,物质结构与社会结构双向老化。房屋产权细碎化,预期收益不稳定,使得地方财政与市场资本的空间生产均趋向交易成本较低的新区,旧城则被负向循环锁定。小公园街区从改善居住条件到追求城市土地收益,经历了“见缝插针”式的独栋危房改造、“成片配套”式的居住组团建设、“大拆大建”式的空间生产三个改造阶段,最终政绩效应与市场利益的契合使小公园街区的改造沦为权力和资本主导下以

  15. A perspectiva histórico-dialética da periodização do desenvolvimento infantil La perspective histórica-dialéctica de la periodización del desarrollo infantil Historic-dialectical perspective on child development stages

    Directory of Open Access Journals (Sweden)

    Juliana Campregher Pasqualini


    éctico. Se presentan los períodos del desarrollo infantil provisoriamente identificados por Vigotski y, por fin, el análisis de Leontiev y Elkonin sobre la periodicidad del desarrollo en la infancia apoyada en el concepto de actividad rectora.This paper presents an analysis of the child development’s stages under the historic-cultural perspective. The principles and fundamentals which should support periodization of child development according to Vigotski are presented, seeking to highlight the historical and dialectical character of his propositions. The paper also briefly presents Leontiev and Elkonin important contributions to this issue. Initially, the importance of an historic approach to child development is discussed, emphasizing the relationship between child and society and the concrete historic conditions as determiners of the child development process. Then, the fundamentals of age periodization in child development proposed by Vigotski are introduced, pointing the relationship between his propositions and the principles of the dialectical method. Next, the periods of child development provisionally identified by Vigotski are presented, followed by Leontiev and Elkonin analysis of periodization in child development from the category of main activity.

  16. VT Historic Preservation Grant (United States)

    Vermont Center for Geographic Information — The State-funded Historic Preservation Grant Program helps municipalities and non-profit organizations rehabilitate the historic buildings that are a vital part of...

  17. Teorias econômicas de oferta de educação: evolução histórica, estado atual e perspectivas Economic theories of the supply of education: historical evolution, current state, and perspectives

    Directory of Open Access Journals (Sweden)

    Fábio D. Waltenberg


    Full Text Available Este artigo preocupa-se com uma faceta particular (o lado da oferta de uma das duas grandes linhas de pesquisa em economia da educação (aspectos econômicos dos sistemas educacionais. Apresentam-se a evolução histórica, o estado atual do debate e as perspectivas de desenvolvimento das teorias econômicas de oferta de educação, abarcando-se o período compreendido entre o início da década de 1960 e as contribuições mais recentes. Argumenta-se que as teorias tradicionais de economia da educação (capital humano e sinalização não deram tratamento adequado ao lado da oferta da educação. Mais tarde, os conceitos e o instrumental da microeconomia da firma foram mobilizados a fim de se tentar mapear a "tecnologia de produção de educação". A abordagem das funções de produção de educação, baseadas inicialmente apenas em insumos monetários, não foi suficiente para que se apreendesse toda a complexidade envolvida no processo de provisão de educação. Uma análise de artigos mais recentes revela três caminhos promissores para o desenvolvimento das teorias de oferta de educação: (i incluir insumos não monetários às funções de produção; (ii levar em consideração aspectos institucionais e organizacionais do sistema educativo; e (iii aprimorar as técnicas econométricas de estimação das funções de produção. Por fim, o artigo discute mais detidamente o primeiro desses três caminhos.The present article deals with a particular aspect (the side of the supply of one of the two main lines of research in the economics of education (economical aspects of educational systems. It shows the historical evolution, the current state, and the perspectives of development of the economic theories of education supply, covering the period from the early 1960s to the more recent contributions. It argues that the traditional theories of the economics of education (human capital and screening have not dealt adequately with the


    Directory of Open Access Journals (Sweden)

    Rodríguez Arocho Wanda


    Full Text Available Resumen:En este ensayo se analiza la relación entre aprendizaje, desarrollo y evaluación en contextos educativos desde el enfoque históricocultural. Como método de trabajo se ha utilizado el análisis de discurso de las formulaciones teóricas originales del enfoque y una revisión de sus desarrollos actuales en investigaciones e intervenciones psicoeducativas. En el análisis, se identifican y se examinan conceptos centrales de este enfoque, paradójicamente poco discutidos, como es el caso del concepto unidad de análisis. Nuestro estudio revela una estrecha relación entre los procesos de aprendizaje (apropiación y dominio de artefactos y signos culturales, desarrollo (transformaciones en la conciencia y la subjetividad enraizadas en dinámicas históricoculturales y socioinstitucionales, y evaluación (herramienta que puede incidir sobre ambos procesos. Se presentan y discuten algunos ejemplos concretos de prácticas de evaluación que pueden promover el aprendizaje y el desarrollo. Se concluye que, desde el enfoque históricocultural, aprendizaje, desarrollo y evaluación, constituyen una unidad indivisible con serias implicaciones para las prácticas docentes y las investigaciones psicoeducativas. Estas implicaciones obligan a realizar una mirada crítica de las formas tradicionales de pensar y hacer evaluación en contextos educativos.Abstract: This essay analyzes the relationship between learning, development and assessment in educational contexts from a cultural-historical perspective. The methodological approach to analysis includes discourse analysis of the original theoretical formulations and a review of current developments in psychoeducational research and intervention. The analysis identifies and examines central concepts in the cultural-historical perspective, paradoxically not frequently discussed, as is the case with the concept of unit of analysis. Our analysis reveals a close relationship of interdependency between

  19. Inverse perspective (United States)

    Dolinsky, Margaret


    This paper will discuss the potentiality towards a methodology for creating perceptual shifts in virtual reality (VR) environments. A perceptual shift is a cognitive recognition of having experienced something extra-marginal, on the boundaries of normal awareness, outside of conditioned attenuation. Definitions of perceptual shifts demonstrate a historical tradition for the wonder of devices as well as analyze various categories of sensory and optical illusions. Neuroscience and cognitive science attempt to explain perceptual shifts through biological and perceptual mechanisms using the sciences. This paper explores perspective, illusion and projections to situate an artistic process in terms of perceptual shifts. Most VR environments rely on a single perceptual shift while there remains enormous potential for perceptual shifts in VR. Examples of artwork and VR environments develop and present this idea.

  20. Cosmic Perspectives (United States)

    Biswas, S. K.; Mallik, D. C. V.; Vishveshwara, C. V.


    1. Astronomy in ancient and medieval China Joseph Needham; 2. Indian astronomy: an historical perspective B. V. Subbarayappa; 3. Making of astronomy in ancient India Debiprasad Chattopadhyaya; 4. The impact of astronomy on the development of western science Jean-Claude Pecker; 5. Man and the Universe Hubert Reeves; 6. Understanding the Universe - challenges and directions in modern observational astronomy Harlan Smith, Jr: 7. Frontiers in cosmology Fred Hoyle; 8. Did the Universe originate in a big bang? Jayant Narlikar; 9. The dark matter problem Bernard Carr; 10. Geometry and the Universe C. V. Vishveshwara; 11. The origin and evolution of life Cyril Ponnamperuma; 12. The anthropic principle: self selection as an adjunct to natural selection Brandon Carter; 13. Astrology and science: an examination of the evidence Ivan Kelly, Roger Culver and Peter Loptson; 14. Astronomy and science fiction Allen Janis.

  1. Building Collections. Historical Fiction (United States)

    Krapp, JoAnn Vergona


    At least once a year, teachers generally request a historical fiction assignment. Bare facts make dry reading but historical fiction, set in an actual time period with plausible dialogue and credible characters, is more palatable to youngsters. This column discusses the most widely-requested historical periods of study for intermediate and upper…

  2. Democracy and Historical Writing

    NARCIS (Netherlands)

    de Baets, Antoon


    In this essay, we try to clarify the relationship between democracy and historical writing. The strategy is first exploring the general relationship between democracy and historical awareness, and then, studying the relationship between democracy and historical writing itself to find out whether dem

  3. Performer rights and responsibilities in historical performance

    Directory of Open Access Journals (Sweden)

    Irving John


    Full Text Available In April 2014, fortepianist and Mozart specialist John Irving recorded a CD of solo keyboard sonatas by Joseph Haydn, using a modern copy of a Viennese fortepiano of Haydn’s era. This is an account of the project written from the performer’s perspective, examining some relevant issues of historical performance practice, organology, and detailed reflections upon the performer’s preparations (of various musical and technical kinds for the recording.

  4. Making Connections with Historical Fiction. (United States)

    Nawrot, Kathy


    Discusses the value of historical fiction, using historical fiction to teach history and to teach literature, and activities using historical fiction. Offers a sample approach using the book "Underground to Canada," and notes cautions in using historical fiction. (SR)

  5. Durability of Silicate Glasses: An Historical Approach

    Energy Technology Data Exchange (ETDEWEB)

    Farges, Francois; /Museum Natl. Hist. Natur. /Stanford U., Geo. Environ. Sci.; Etcheverry, Marie-Pierre; /Marne la Vallee U.; Haddi, Amine; /Marne la Valle U.; Trocellier,; /Saclay; Curti, Enzo; /PSI, Villigen; Brown, Gordon E., Jr.; /SLAC, SSRL


    We present a short review of current theories of glass weathering, including glass dissolution, and hydrolysis of nuclear waste glasses, and leaching of historical glasses from an XAFS perspective. The results of various laboratory leaching experiments at different timescales (30 days to 12 years) are compared with results for historical glasses that were weathered by atmospheric gases and soil waters over 500 to 3000 years. Good agreement is found between laboratory experiments and slowly leached historical glasses, with a strong enrichment of metals at the water/gel interface. Depending on the nature of the transition elements originally dissolved in the melt, increasing elemental distributions are expected to increase with time for a given glass durability context.

  6. Genetic origin of Behçet's disease population in Denizli, Turkey; population genetics data analysis; historical demography and geographical perspectives based on β-globin gene cluster haplotype variation. (United States)

    Ozturk, O; Arikan, S; Bahadir, A; Atalay, A; Atalay, E O


    In our study, we aimed to investigate the possible genetic drift, relationships, expansion and historical origin based on haplotype frequencies of the β-globin gene cluster of normal and Behçet's disease (BD) population in Denizli, Turkey. We examined blood DNA samples obtained from our DNA bank. The association of population genetic parameters such as haplotypes, diversity, differentiation, Hardy-Weinberg equilibrium and demographic analysis for two populations was performed by Arlequin ver. 3.5. Our results show that both populations have high similarity in genetic parameters in terms of development and expansion based on haplotype diversity through the history. We found that historical levels of gene flow were significantly higher between the two populations. According to historical population, growth parameter of τ values for normal and BD populations dated approximately 42 000 to 38 000 ybp, respectively. In conclusion, historically, two populations show similar genetic parameters and unimodal growth distribution. Our results are consistent with the view that the BD may have occurred in area, independent from Silk Road.

  7. Historically defined autobiographical periods

    DEFF Research Database (Denmark)

    Brown, Norman R.; Hansen, Tia G. B.; Lee, Peter J.;


    The chapter reviews a research programme that has demonstrated the existence of historically defined autobiographical periods and identified the conditions that bring them about. Data from four samples of World War II-generation adults show that historically defined autobiographical periods endure...... over time and theoretical implications are discussed, notably by introducing a new approach to autobiographical memory, Transition Theory, which assumes that autobiographical memory is organized by transitional events that can be selfinitiated or externally imposed - historically defined...


    Directory of Open Access Journals (Sweden)

    Cristhyane Ramos Haddad


    Full Text Available This article presents the historical-critical pedagogy and historical-cultural psychology, also rehearses to make inferences for teacher training in Brazil. Therefore, was sought to theoretical base in authors such as Dermeval Saviani, Newton Duarte, Vygotsky, Leontiev, Ligia Marcia Martins, Marilda Facci, Marta Sforni. The historical-critical pedagogy postulates that the educational actis characterized by intentionality, aiming as objective the appropriation of knowledge systematized by the student. In the same sense, the historical- cultural psychology understands that the learning of knowledge scholarship is critical for the development of higher psychological functions. The good teaching in this perspective is the one that promotes the development of the individual that is always asocial and historical development. These approaches are confronting and overcoming the pedagogies of learning to learn that find their foundation in constructivism and who claim that more important than teaching or learning is to take the student to find ways to learn how to learn. The teacher’s job, according to these pedagogies, is of a learning facilitator, which has led to an undermining of their function and causing serious consequences for the teaching learning process of students in the classroom. Finally, this article points according to the marxist perspective the omnilateral defense of teachers training as an indispensable element for the progress toward the consolidation of a quality public education.

  9. Educação Infantil: o lugar da Pedagogia e da Educação Física em uma perspectiva Sócio-Histórico-Dialética Infant Eductation: The Place of Pedagogy and of Physical Education in a Social-Historical-Dialectic Perspective

    Directory of Open Access Journals (Sweden)


    Full Text Available O objetivo deste artigo é realizar um exercício reflexivo sobre as relações entre Pedagogia e Educação Física e suas contribuições para a educação da infância em uma perspectiva sócio-histórico-dialética. Para isso, organizamos os textos em três momentos: o primeiro tem como finalidade resgatar a constituição histórica dos projetos em educação infantil no Brasil; o segundo busca delimitar as proposições fundamentais da perspectiva sóciohistórico-dialética, e, por último, indicamos caminhos a serem percorridos pelas duas áreas de conhecimento em debate, Educação Física e Pedagogia. PALAVRAS-CHAVE: Educação infantil - Pedagogia - Educação The aim of this article is to reflect upon the relations between Pedagogy and Physical Education and their contributions to infant education in a social-historical-dialectic perspective. To achieve this, we have organized this text in three parts: the first one aims at recollecting the historical constitution of projects on infant education in Brazil; the second part aims at defining the scope for thefundamental propositions of this social-historicaldialectic perspective. Lastly, we indicate paths that can be followed by these two fields of knowledge that are discussed here, physical education and pedagogy. KEY WORDS: Infant education - Pedagogy - Physical education.

  10. Creating Historical Drama. (United States)

    Cassler, Robert


    Describes creating for the National Archives Public Education Department a historical drama, "Second in the Realm," based on the story of the Magna Carta. Demonstrates the effectiveness of historical drama as a teaching tool. Explains the difficulties of writing such dramas and provides guidelines for overcoming these problems. (NL)

  11. Possible consequences of increasing life expectancy in Brazil: the perspective of a European historical demographer Possíveis conseqüências da crescente longevidade no Brasil: perspectiva de um demógrafo

    Directory of Open Access Journals (Sweden)

    Arthur E. Imhof


    Full Text Available Those over sixty years of age accounted for 6.6% of the total population of Brazil in 1985, in the Federal Republic of Germany this proportion was 20.3% in 1984. As early as 1950 it had been 14.5%. This proportion will not even be reached in Brazil in the year 2000 when persons aged sixty years and older are only projected to make up 8.8% of the total population. Similarly, in 1982/84 life expectancy at birth in the Federal Republic was 70.8 years for men and 77.5 for women; in Brazil the figures for 1980/85 were, by contrast, "only" 61.0 and 66.0. Against this background it is easy to understand why the discussion concerning an ageing society with its many related medical, economic, individual and social problems has been so slow in coming into its own in Brazil. As important as a more intensive consideration of these aspects may be in Brazil at present, they are, nevertheless, only one side of the story. For a European historical demographer with a long-term perspective of three of four hundred years, the other side of the story is just as important. The life expectancy which is almost ten years lower in Brazil is not a result of the fact that no one in Brazil lives to old age. In 1981 people sixty-five years and older accounted for 34.4% of all deaths! At the same time infants accounted for only 22.1% of total mortality. They are responsible, along with the "premature" deaths among youths and adults, for the low, "average" life expectancy figure. In Europe, by contrast, these "premature" deaths no longer play much of a role. In 1982/84 more than half of the women (52.8% in the Federal Republic of Germany lived to see their eightieth birthdays and almost half of the men (47.3% lived to see their seventy-fifth. Our biological existence is guaranteed to an extent today that would have been unthinkable a few generations ago. Then, the classic troika of "plague, hunger and war" threatened our forefathers all the time and everywhere. The radical

  12. Play: Dormant Issues and New Perspectives. (United States)

    Vandenberg, Brian


    Discusses the role of play in development from both cultural-evolutionary and ontogenetic-historical perspectives. These perspectives illuminate how play and imitation are important for the developing individual who is seen as influencing a changing cultural environment. (Author/RH)

  13. Historical Museums in Israel: Semiotics of Culture

    Directory of Open Access Journals (Sweden)

    Gabriel Mayer


    Full Text Available Tiny by physical size, the State of Israel retains some of the world’s most important cultural treasures, along with many other great cultural institutions. Archeological treasures have yielded much information as far as biblical history and have been well adapted to a Zionist narrative by both the Jewish press and international news organizations, such as the New York Times whose archives are replete with reports of Jewish history being dug up by the Jewish people. Once the State of Israel gained independence in 1948, the course was set for the development of historical museums whose discourse would reflect the most significant events in Jewish history, most especially the Holocaust and the state of constant warfare that continues to imbue the cultural consciousness of its citizens. In this paper we outline, through categorization, the various historical museums, which are currently operating. Furthermore, this article hopes to shed some light upon the cultural sensibilities conveyed through these institutions. This paper is about Israeli culture, mythology, and collective needs, as formed by and informed through a variety of historical museums. The working assumption is that in a historical museum culture is partially formed and at the same time the culture is influencing the contents and narratives on display inside the museum. It should be clear from the start that the discussion is held about Israeli museums as viewed by a Jewish population and created by and for Jews. Notwithstanding the multifaceted collective of Israeli society, this work is confined to and circumscribed by this demarcation. In the following sections, I intend to provide an explanation for this viewpoint from a historical perspective and also provide a framework of what constitutes a historical museum and justify the methodology of its employ. This will be followed by a discussion of the main categorical types of historical museums present in Israel, and finally a

  14. The historical supernovae

    CERN Document Server

    Clark, David H


    The Historical Supernovae is an interdisciplinary study of the historical records of supernova. This book is composed of 12 chapters that particularly highlight the history of the Far East. The opening chapter briefly describes the features of nova and supernova, stars which spontaneously explode with a spectacular and rapid increase in brightness. The succeeding chapter deals with the search for the historical records of supernova from Medieval European monastic chronicles, Arabic chronicles, astrological works etc., post renaissance European scientific writings, and Far Eastern histories and

  15. History of Historical Archaeology

    Directory of Open Access Journals (Sweden)

    Robert L. Schuyler


    Full Text Available On Sunday April 19, 1998 Jean Carl Harrington (known to the profession as J.C. or "Pinky" Harrington passed away at his home in Richmond, Virginia. At 96 Harrington's life almost spanned the 20th century and did encompass the rise and establishment of professional Historical Archaeology in North America. Many consider Harrington to be the founder or "father" of Americanist Historical Archaeology. In 1936 he took over the newly created NPS-CCC project at Jamestown, Virginia and that event is arguably the inception of Historical Archaeology as an organized, scholarly discipline.

  16. Historical Climatology Series (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Historical Climatology Series (HCS) is a set of climate-related publications published by NOAA's National Climatic Data Center beginning in 1978. HCS is...

  17. Historical Survey Data Archive (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — To preserve NEFSC historical data, images of biological and oceanographic data sheets (1948-1975) were scanned to digital format and can be queried through a portal...

  18. Iowa Historic Cemeteries (United States)

    Iowa State University GIS Support and Research Facility — This shape file represents Iowa Historic Cemeteries. Originally it was based on an Iowa DNR point file marking cemetery locations as found on 7.5 min. USGS quad...

  19. Historical Development of Newton's Laws of Motion and Suggestions for Teaching Content (United States)

    Chang, Wheijen; Bell, Beverley; Jones, Allister


    A review of the history of Newton's Laws of Motion illustrates that the historical development gradually shifted away from intuitive experiences and daily life conventions towards a scientific regulated perspective. Three stages of the historical development are discussed, i.e. prior to the Principia, the 3rd (last) edition of the Principia,…

  20. Developing Critical and Historical Thinking Skills in Middle Grades Social Studies (United States)

    Waring, Scott M.; Robinson, Kirk S.


    The author describes a social studies unit designed to help students develop critical thinking skills. The lessons give students opportunities to analyze multiple perspectives, use multiple sources when conducting research, and construct historical narratives through the creation of a digital historical biography.