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Sample records for hormesis historical perspective

  1. Radiation hormesis: an ecological and energetic perspective.

    Science.gov (United States)

    Parsons, P A

    2001-09-01

    Organisms in natural habitats are exposed to an array of environmental stresses, which all have energetic costs. Under this ecological scenario, hormesis for ionizing radiation becomes an evolutionary expectation at exposures substantially exceeding background. This conclusion implies that some relaxation of radiation protection criteria is worthy of serious consideration. Copyright 2001 Harcourt Publishers Ltd.

  2. Historical perspective

    International Nuclear Information System (INIS)

    Davis, E.M.

    1982-01-01

    A historical perspective of the nuclear waste issue is presented, beginning from the Atoms for Peace Legislation which made nuclear technology available to private industry in 1953 to 1954. Once the nuclear process had been demonstrated to be a technically and economically feasible method to convert thermal energy for electric power generation, commercial application began. The issue of nuclear waste management did not keep up with higher priorities. As early as 1957, research into storing the waste in geological structures was conducted by the National Academy of Sciences, and considerable technical progress was made in the 60's. During the 60's and 70's, numerous legislative actions (e.g., Clean Air Act, Clean Water Act, Environmental Policy Act) had a significant impact on nuclear waste dipsosal decisions. In 1971 to 1972 the Atomic Energy Commission authorized a nuclear waste repository in Kansas, a decision which was amended the following year and finally abandoned altogether in 1974. The OPEC oil embargo and ensuing price actions moved nuclear power into a more prominent position in the United States' plans for energy independence. This increased the stress between environmental concerns and economic need. The Carter Administration indefinitely deferred reprocessing of spent fuel and initiated a government-wide review of nuclear policy issues. The Congress did not actively begin to fashion a nuclear waste program until February 1980. The legislation which passed the Senate in the Spring of '82, and a compromise version pending before the House, may resolve the issue by establishing a long-term stable policy which will contain milestones, goals and specific decision making processes; it will include a mechanism for the public and the states to be involved; and it will insure adequate financing provisions

  3. Historical perspective

    Science.gov (United States)

    Landsberg, H. E.

    It was a pleasure to learn, from a recent (May 4) issue of Eos, of the formation of a permanent Committee on History of Geophysics. There is a dire need for reference material, books, and articles on geophysical history.Let me recommend to them that they take a good look at the Dictionary of the History of Science (W.F. Bynum, E.J. Browne, Roy Porter (Eds.), Princeton University Press, 494 pp., 1981). What follows is not a book review, although it may appear so. It is meant to be a challenge to place geophysics on the map in historical context. In this book, hydrology is dealt with in one sentence under the heading ‘cycle,’ geomagnetism under ‘declination and dip,’ and its history ends with Edward Sabine. Seismology appears under earthquakes. No important seismologist is mentioned. In the biographical index, Wiechert is included only for a contribution to physics. Where are Sir Harold Jeffreys, Galitzin, Gutenberg, Mohorovičić, Lehman, and many others? Meteorology ends with V. Bjerknes and Solberg; Köppen, Richardson, Rossby, and other notables [of] the last century do not seem to exist.

  4. Postconditioning hormesis put in perspective: an overview of experimental and clinical studies.

    Science.gov (United States)

    Wiegant, F A C; Prins, H A B; Van Wijk, R

    2011-01-01

    A beneficial effect of applying mild stress to cells or organisms, that were initially exposed to a high dose of stress, has been referred to as 'postconditioning hormesis'. The initial high dose of stress activates intrinsic self-recovery mechanisms. Modulation of these endogenous adaptation strategies by administration of a subsequent low dose of stress can confer effects that are beneficial to the biological system. Owing to its potentially therapeutic applications, postconditioning hormesis is subject to research in various scientific disciplines. This paper presents an overview of the dynamics of postconditioning hormesis and illustrates this phenomenon with a number of examples in experimental and clinical research.

  5. Radiation hormesis

    International Nuclear Information System (INIS)

    Hattori, Sadao; Nemoto, Kazuyasu; Ishida, Kenzi; Misonoo, Jun; Suganuma, Hirotoshi; Ishi, Keiichirou; Yamaoka, Kiyonori

    1990-01-01

    Greater attention has recently been drawn to the hormesis effect of radiations on living things. An agent is said to show hormesis when it gives a favorable physiological stimulation to living things and activated their biological functions if used in slight amounts, though it has an adverse effect on them if used in large amount. Recently many reports have been published which insist that radiations in a certain low dose range can have favorable biological effects, such as stimulation and activation, on living things including humans, animals and plants. Thus hormesis can be seen very widely in the biological field. The report first describes recent trends in research in this field, including the background behind the proposal of the radiation hormesis hypothesis, and major studies presented at the Oakland and Frankfurt Conferences. Then it outlines major research efforts that have been made at Denryoku Chuo Kenkyusho in Japan, focusing on animal tests (superoxidedismutase activity, thymidinekinase activity, etc.), immunological surveys, and plant tests. Discussion is also made concerning important issues and study subjects to be covered in future research. (N.K.)

  6. Einstein: A Historical Perspective

    Science.gov (United States)

    Kormos-Buchwald, Diana

    2015-04-01

    In late 1915, Albert Einstein (1879-1955) completed as series of papers on a generalized theory of gravitation that were to constitute a major conceptual change in the history of modern physics and the crowning achievement of his scientific career. But this accomplishment came after a decade of intense intellectual struggle and was received with muted enthusiasm. Einstein's previously unpublished writings and massive correspondence, edited by the Einstein Papers Project, provide vivid insights into the historical, personal, and scientific context of the formulation, completion, and reception of GR during the first decades of the 20th century.

  7. Basavarajeeyam: A historical perspective.

    Science.gov (United States)

    Nishteswar, K

    2011-10-01

    Basavarajeeyam is an important handbook for an Ayurvedic physician of Andhra region. It is a bilingual work and the content was presented in Sanskrit and Telugu languages. With regard to the place and date of Basavarajeeyam there is no common opinion among the present day scholars. Pt Govardhana Sharma Changani in his introduction to the Sanskrit version of Basavarajeeyam exposed a historical profile of Basavrajeeyam picturising him as Basava who was a staunch follower of Veerashaivism and a contemporary of king Bijjala (end of 12(th) cent. AD). The same statement is carried out in the works of Ayurvedic Itihasa written by Atredeva Vidyawalkan and Acharya Priyavrata Sharma. It appears that the historical evidence shown by these scholars is one sided and cannot stand any reason. Basavraju stated that he had started writing this work after a thorough study of many works such as Charaka, Nithyanatheeyam (1360 AD), Revenakalpam, Pujyapadiyam, Bahatam, Kashikhandam (1435 AD) etc. Basavraju has faithfully reproduced certain chapter of Vaidyachintamani, which is considered to be a work of 15(th) century. Basavraju not only mentioned Phirangiroga in the index of diseases described by him at the end of the book, but also indicated Phirangichekka (Madhusnuhi) in the management of Meharoga and Granthi. By this evidence Basavarajiyam should be considered as the work of post Bhavaprakasha period. Basavraju indicates in the Gulmaroga Chikitsa that Sankhadravaka should be administered in the dose of 'Ekanni'. The name Ekanni was given for a copper coin which came in to circulation of money during British India produced from Madras mint (1794 AD). Based on these internal evidences, it can be safely concluded that Basavraju belong to 18(th)century.

  8. Hormesis and Female Sex Hormones

    Directory of Open Access Journals (Sweden)

    Elvar Theodorsson

    2011-05-01

    Full Text Available Hormone replacement after menopause has in recent years been the subject of intense scientific debate and public interest and has sparked intense research efforts into the biological effects of estrogens and progestagens. However, there are reasons to believe that the doses used and plasma concentrations produced in a large number of studies casts doubt on important aspects of their validity. The concept of hormesis states that a substance can have diametrically different effects depending on the concentration. Even though estrogens and progestagens have proven prone to this kind of dose-response relation in a multitude of studies, the phenomenon remains clearly underappreciated as exemplified by the fact that it is common practice to only use one hormone dose in animal experiments. If care is not taken to adjust the concentrations of estrogens and progestagens to relevant biological conditions, the significance of the results may be questionable. Our aim is to review examples of female sexual steroids demonstrating bidirectional dose-response relations and to discuss this in the perspective of hormesis. Some examples are highlighted in detail, including the effects on cerebral ischemia, inflammation, cardiovascular diseases and anxiety. Hopefully, better understanding of the hormesis phenomenon may result in improved future designs of studies of female sexual steroids.

  9. Hormesis, an update of the present position

    International Nuclear Information System (INIS)

    Johansson, Lennart

    2003-01-01

    The ongoing debate over the possible beneficial effects of ionising radiation on health, hormesis, is reviewed from different perspectives. Radiation hormesis has not been strictly defined in the scientific literature. It can be understood as a decrease in the risk of cancer due to low-dose irradiation, but other positive health effects may also be encompassed by the concept. The overwhelming majority of the currently available epidemiological data on populations exposed to ionising radiation support the assumption that there is a linear non-threshold dose-response relationship. However, epidemiological data fail to demonstrate detrimental effects of ionising radiation at absorbed doses smaller than 100-200 mSv. Risk estimates for these levels are therefore based on extrapolations from higher doses. Arguments for hormesis are derived only from a number of epidemiological studies, but also from studies in radiation biology. Radiobiological evidence for hormesis is based on radio-adaptive response; this has been convincingly demonstrated in vitro, but some questions remain as to how it affects humans. Furthermore, there is an ecologically based argument for hormesis in that, given the evolutionary prerequisite of best fitness, it follows that humans are best adapted to background levels of ionising radiation and other carcinogenic agents in our environment. A few animal studies have also addressed the hormesis theory, some of which have supported it while others have not. To complete the picture, the results of new radiobiological research indicate the need for a paradigm shift concerning the mechanisms of cancer induction. Such research is a step towards a better understanding of how ionising radiation affects the living cell and the organism, and thus towards a more reliable judgement on how to interpret the present radiobiological evidence for hormesis. (orig.)

  10. Radonotherapy and radiation hormesis

    International Nuclear Information System (INIS)

    Gusarov, I.I.; Dubovskoj, A.V.

    1999-01-01

    Based on the analysis of published data the concept is discussed concerning the fact that emission of Rn-222 and its daughter products containing in the atmospheric and accommodation air, at certain dose range is a natural stimulator for adaptive and defense forces of organism, improves viability and resistance to oncological diseases. Positive effect of Rn and its daughter products on vital activity of living organisms is considered to be the radiation hormesis manifestation. It is concluded that the medical effect of radon procedures is also the radiation hormesis evidence. From this viewpoint the hypothesis on mechanism of their biological and therapeutic effect is presented [ru

  11. The INIS Thesaurus: historical perspective

    International Nuclear Information System (INIS)

    Duresa, Bekele Negeri; Vakula, Olga

    2015-01-01

    The INIS Thesaurus is a controlled terminological knowledge base that has been developed over the years through the contribution of INIS Member States in all areas of peaceful applications of nuclear science and technology, which is also the subject scope of the INIS Collection. The thesaurus is primarily used for subject indexing of input into the INIS system and for retrieval of information from the database. Thanks to the vital support of INIS Member States, the thesaurus has been translated into eight languages (i.e. all IAEA official languages plus German and Japanese) and is available online to assist our global users as a tool for retrieval and for general reference. It is a dynamic information resource that is continually updated to cater to new developments of terminologies in nuclear science and technology. Since its inception in the 1960’s, it was decided that the subject analysis for INIS input preparation be based on its own subject categories, which also determines its scope, and keyword indexing using a thesaurus. This article briefly describes the development of the INIS Thesaurus from a historical perspective

  12. Radium in consumer products: an historical perspective

    International Nuclear Information System (INIS)

    Holm, W.M.

    1978-01-01

    This paper demonstrates in historical and technical perspective how radium began to be used in consumer products and how changing conditions in technology and regulations have greatly modified the use of radium. In addition, the various uses of radium that have been tried or have been used in consumer products have been described, and whenever possible, the historical perspective has been used to show when devices were needed and when changing conditions caused the products to be no longer required. The historical perspective attitude is again used in the evaluation of the risks and benefits of radium in comparison to radium substitutes

  13. Open source software development : some historical perspectives

    NARCIS (Netherlands)

    Nuvolari, A.

    2005-01-01

    In this paper we suggest that historical studies of technology can help us to account for some, perplexing (at least for traditional economic reasoning) features of open source software development. From a historical perspective, open source software seems to be a particular case of what Robert C.

  14. Open source software development : some historical perspectives

    NARCIS (Netherlands)

    Nuvolari, A.

    2003-01-01

    In this paper we suggest that historical studies of technology can help us to account for some, perplexing (at least for traditional economic reasoning) features of open source software development. When looked in historical perspective, open source software seems to be a particular case of what

  15. VARIETIES OF SOCIAL DISCIPLINING, HISTORICAL PERSPECTIVES.

    Directory of Open Access Journals (Sweden)

    Tomás A. Mantecón Movellán

    2011-04-01

    Full Text Available Historical thought has tended to explain social disciplining according to two main analytical perspectives: on one hand, German tradition about the so-called sozialdisziplinierung and, on the other hand, Foucault perspectives (focussed on disciplines practiced on the bodies-and/or-minds of people by the authorities. From these both viewpoints social disciplining was a dynamic ingredient of change, from traditional societies up to contemporary liberal societies; a machinery to provoke top-down changes (from above. On the bases of historical evidences, this research claims for a third viewpoint that stresses dynamics of social discipline and social disciplining from below; underlines the need of integrating this third perspective in the historical explanation of change in past societies throughout the analysis of social practices of everyday life; the values underneath them and, in the end, taking into account varieties of discipline and perspectives of social disciplining from below.

  16. A Historical Perspective on Gender.

    Science.gov (United States)

    St. Pierre, Elizabeth A.

    1999-01-01

    Traces perspectives on gender and gender discrimination over the last several decades, as they affect schools and English classrooms. Discusses feminism/feminisms, "add women and stir," sex differences, resistance and backlash, intersections of identity categories, and multiculturalism. Argues that English teachers can be powerful agents in the…

  17. Japan 2006 in historical perspectives

    Directory of Open Access Journals (Sweden)

    Michiko Tanaka Nishishima

    2007-11-01

    Full Text Available Readings of the current Japanese politics with the historic and social insight through analysis of four facts registered in 2006: the visit of the prime minister Koizumi to the Yasukuni shrine; the election of Abe Shinzo as the president of Liberal Democratic Party and the formation of Abe cabinet; the Atomic bomb experimentation by the North Corea; the publication of the book of feminist counteroffensive against the numerous rightist conservative harassment.

  18. Radiation hormesis in plant

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jae Sung; Song, Hi Sup; Lee, Young Keun; Lee, Byung Hun; Shin, In Chul; Lim, Young Taek

    2000-04-01

    This research was performed to investigate the effects of low dose {gamma}-ray radiation on the seed germination and the following physiological responses in vegetable crops. Special attention was focused on whether the resistance of vegetables against the unfavorable conditions of environment such as subsequent high doses of radiation or Phytophthora blight of pepper could be enhanced as an aspect of radiation hormesis. Analysis and characterization of antioxidant enzyme from plant culture cells and radiation tolerant of transformed plants from antioxidant (POD) were accomplished in the plant irradiated with different dose of {gamma}-ray. (author)

  19. Radiation hormesis in plant

    International Nuclear Information System (INIS)

    Kim, Jae Sung; Song, Hi Sup; Lee, Young Keun; Lee, Byung Hun; Shin, In Chul; Lim, Young Taek

    2000-04-01

    This research was performed to investigate the effects of low dose γ-ray radiation on the seed germination and the following physiological responses in vegetable crops. Special attention was focused on whether the resistance of vegetables against the unfavorable conditions of environment such as subsequent high doses of radiation or Phytophthora blight of pepper could be enhanced as an aspect of radiation hormesis. Analysis and characterization of antioxidant enzyme from plant culture cells and radiation tolerant of transformed plants from antioxidant (POD) were accomplished in the plant irradiated with different dose of γ-ray. (author)

  20. Radiation hormesis in plant

    International Nuclear Information System (INIS)

    Kim, Jae Sung; Song, Hi Sup; Lee, Young Keun; Cun, Ki Jung; Shin, In Chul; Lim, Young Taek

    1999-04-01

    This research was performed to investigate the effects of low dose γ-ray radiation on the seed germination and the following physiological responses in vegetable crops. Special attention was focused on whether the resistance of vegetables against the unfavorable conditions of environment such as acid rain or soil types could be enhanced as an aspect of radiation hormesis. Analysis and characterization of antioxidant enzyme from plant culture cells and radiation tolerant of transformed plants from antioxidant enzyme (POD) were accomplished in the plant irradiated with difference dosage of γ-ray

  1. Radiation hormesis in plant

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jae Sung; Song, Hi Sup; Lee, Young Keun; Cun, Ki Jung; Shin, In Chul; Lim, Young Taek

    1999-04-01

    This research was performed to investigate the effects of low dose {gamma}-ray radiation on the seed germination and the following physiological responses in vegetable crops. Special attention was focused on whether the resistance of vegetables against the unfavorable conditions of environment such as acid rain or soil types could be enhanced as an aspect of radiation hormesis. Analysis and characterization of antioxidant enzyme from plant culture cells and radiation tolerant of transformed plants from antioxidant enzyme (POD) were accomplished in the plant irradiated with difference dosage of {gamma}-ray.

  2. Supporting Exploration of Historical Perspectives across Collections

    NARCIS (Netherlands)

    Odijk, Daan; Garbacea, Cristina; Schoegje, Thomas; Hollink, Laura; de Boer, Victor; Ribbens, Kees; van Ossenbruggen, Jacco

    2015-01-01

    The ever growing number of textual historical collections calls for methods that can meaningfully connect and explore these. Different collections offer different perspectives, expressing views at the time of writing or even a subjective view of the author. We propose to connect heterogeneous

  3. Supporting Exploration of Historical Perspectives Across Collections

    NARCIS (Netherlands)

    Odijk, D.; Gârbacea, C.; Schoegje, T.; Hollink, L.; de Boer, V.; Ribbens, K.; van Ossenbruggen, J.; Kapidakis, S.; Mazurek, C.; Werla, M.

    2015-01-01

    The ever growing number of textual historical collections calls for methods that can meaningfully connect and explore these. Different collections offer different perspectives, expressing views at the time of writing or even a subjective view of the author. We propose to connect heterogeneous

  4. Dermatotoxicology: Historical perspective and advances

    International Nuclear Information System (INIS)

    Ngo, Mai A.; Maibach, Howard I.

    2010-01-01

    The fundamental principles underlying the study of dermatotoxicology were developed by Arnold Lehman and John Draize over a half century ago and remain applicable today. This discipline has proven indispensable for addressing the problems associated with skin exposure to chemicals. The 55th anniversary of Lehman's landmark publication on safety factors presents the opportunity to reflect upon the historical beginnings of dermatotoxicology and the role of regulatory policies on the development of this field over the years. The complexity and sheer volume of information that has been collected makes it difficult to comprehensively cover all aspects of this vast discipline. This overview will touch upon the general concepts of ADME, the various forms of contact dermatitis, and transdermal drug delivery systems. The traditional tests performed in animals and humans to identify allergic or irritant potential of chemicals, in addition to alternative methods such as QSAR modeling will be discussed. The subspecialties of infant and occupational dermatotoxicology, as well as dermatotoxicology of aged and ethnic skin, and skin of the vulva and vagina will also be noted.

  5. Historical perspectives on evidence-based nursing.

    Science.gov (United States)

    Beyea, Suzanne C; Slattery, Mary Jo

    2013-04-01

    The authors of this article offer a review and historical perspective on research utilization and evidence-based practice in nursing. They present the evolution of research utilization to the more contemporary framework of evidence-based nursing practice. The authors address the role of qualitative research in the context of evidence-based practice. Finally, some approaches and resources for learning more about the fundamentals of evidence-based healthcare are provided.

  6. Radiation hormesis in higher plants

    International Nuclear Information System (INIS)

    Kim, Jae Sung

    1996-03-01

    The most remarkable aspect in the hormesis law is that low dose of harmful agents can produce effect that are diametrically opposite to the effect found with high doses of the same agent. Minute quantities of a harmful agent bring about very small change in the organism and control mechanisms appear to subjugate normal processes to place the organism in a state of alert and repair. The stimulated organism is more responsive to changes in environmental factors than it did before being alerted. Routine functions, including repair and defense, have priority for available energy and material. The alerted organism utilizes nutrients more efficiently, grows faster, shows improved defense reactions, matures faster, reproduces more effectively, has less disease, and lives longer. Accelerated germination, sprouting, growth, development, blooming and ripening, and increased crop yield and resistance to disease are found in plants. Another concept supported by the data is that low doses of ionizing radiation provide increased resistance to subsequent high doses of radiation. The hormesis varies with subject plant, variety, state of seed, environmental and cultural conditions, physiologic function measured, dose rate and total exposure. The results of hormesis are less consistently found, probably due to the great number of uncontrolled variables in the experiments. The general dosage for radiation hormesis in about 100 (10 to 1,000) times ambient or 100 (10 to 1,000) times less than a definitely harmful dose, but these must be modified to the occasion. Although little is known about most mechanisms of hormesis reaction, overcompensation of repair mechanism is offered as on mechanism. Radiation hormesis can provide more efficient use of resources, maximum production of foods, and increased health by the use of ionizing radiation as a useful tool in our technologic society. Efficient utilization of nature's resources demands support to explore the practical application of

  7. Radiation hormesis in higher plants

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jae Sung [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

    1996-03-01

    The most remarkable aspect in the hormesis law is that low dose of harmful agents can produce effect that are diametrically opposite to the effect found with high doses of the same agent. Minute quantities of a harmful agent bring about very small change in the organism and control mechanisms appear to subjugate normal processes to place the organism in a state of alert and repair. The stimulated organism is more responsive to changes in environmental factors than it did before being alerted. Routine functions, including repair and defense, have priority for available energy and material. The alerted organism utilizes nutrients more efficiently, grows faster, shows improved defense reactions, matures faster, reproduces more effectively, has less disease, and lives longer. Accelerated germination, sprouting, growth, development, blooming and ripening, and increased crop yield and resistance to disease are found in plants. Another concept supported by the data is that low doses of ionizing radiation provide increased resistance to subsequent high doses of radiation. The hormesis varies with subject plant, variety, state of seed, environmental and cultural conditions, physiologic function measured, dose rate and total exposure. The results of hormesis are less consistently found, probably due to the great number of uncontrolled variables in the experiments. The general dosage for radiation hormesis in about 100 times ambient or 100 times less than a definitely harmful dose, but these must be modified to the occasion. Although little is known about most mechanisms of hormesis reaction, overcompensation of repair mechanism is offered as on mechanism. Radiation hormesis can provide more efficient use of resources, maximum production of foods, and increased health by the use of ionizing radiation as a useful tool in our technologic society. Efficient utilization of nature`s resources demands support to explore the practical application of radiation hormesis.

  8. Radiation hormesis in plant

    International Nuclear Information System (INIS)

    Kim, Jae Sung; Lee, Young Keun; Lee, Sang Jae and others; Park, Youn Il; Kwon, Soon Tae

    2003-05-01

    This research was performed to investigate the effects of low dose gamma radiation on germination, early growth and yield in a wide range of vegetable crops. The stimulating effects of gamma radiation was evaluated through investigating germination rate, early growth and physiological activities such as enzyme activities, hormones and photosynthetic responses etc. Induction of increased shikonin production in the plants by low dose gamma radiation was challenged to open up the possibility of applying radiation hormesis to the industrial mass production system of the natural materials useful to humans. Effects of natural radiation emitted from solid ceramics was compared on the plants with those of low dose gamma radiation. Finally, activation of aged seeds by low dose gamma radiation, probably facilitating their commercial circulation in the agriculture, was challenged in association with an industrial seed company. Moreover, the shift in resistance of the crops to environmental stresses including UV and low temperature was addressed as well as DNA damage, repair and protein expression after gamma irradiation

  9. Management of basilar invagination: A historical perspective

    Directory of Open Access Journals (Sweden)

    Abhidha Shah

    2016-01-01

    Full Text Available For a long time the terms basilar invagination and platybasia were used interchangeably. Basilar invagination has been defined as a prolapse of the vertebral column into the spinal cord. Platybasia is defined as an abnormal obtuse angle between the anterior skull base and the clivus. The authors review the existing literature and summarize the historical and modern perspectives in the management of basilar invagination. From radiological curiosities, the subject of basilar invagination is now viewed as eminently treatable. The more pronounced understanding of the subject has taken place in the last three decades when on the basis of understanding of the biomechanical subtleties the treatment paradigm has remarkably altered. From surgery that involved decompression of the region, stabilization and realignment now form the basis of treatment.

  10. Universities' Engagement with Vocationalism: Historical Perspective

    Directory of Open Access Journals (Sweden)

    Pericles 'asher' Rospigliosi

    2016-12-01

    Full Text Available The aim of this article is to explore the historical context of vocationalism in universities. It is based on an analysis of the history of the university from a vocational perspective. It looks for evidence of vocational engagement in the activities of universities over time, taking a long view from the birth of the Western University in the Middle Ages to the 1980s with the emergence of current issues of vocationalism in university education. It adopts a chronological perspective initially and then a thematic one. The main findings are: (1 vocationalism in university education is as old as the Western University itself, (2 there is evidence from the start of the Western University of vocational engagement in terms of the provision of vocationally relevant subjects, vocationally relevant skills and the development of vocationally relevant attitudes, (3 whereas most graduate employers used to be concerned with the vocationally relevant knowledge, skills and attitudes students acquired on their degree courses, most are now more concerned with graduate capacity and disposition to learn within their employment after graduation and (4 subject-centred education is compatible with university education that supports the vocational aspirations of students.

  11. Neurophysiology of conversion disorders: a historical perspective.

    Science.gov (United States)

    Crommelinck, M

    2014-10-01

    The aim of this paper is to present a short historical perspective on the neurophysiological approach to hysteria and conversion disorders. The body of this paper will be constituted of three main parts. In the first part, we will present the significant progress due to some pioneers of neurology/psychiatry during the XIXth century. As we shall see, this period was particularly rich in personalities whose work gradually laid the foundations to a true medical approach to hysteria. In the first half of the XXth century, different factors have led to a long eclipse of the neurological approach to hysteria. In the second part, we will show how, by the 1960's-1970's, the conceptual and methodological advances in neurophysiology, as well as the turning point of cognitive sciences (and cognitive psychology in particular) allowed a gradual reinstatement of hysteria within the fields of neurology and clinical neurophysiology. Finally, and this is the third part of this paper, we will show how over the past three decades, an entirely new neurophysiological approach to hysteria and conversion disorders has emerged. Copyright © 2013 Elsevier Masson SAS. All rights reserved.

  12. Technical writing in America: A historical perspective

    Science.gov (United States)

    Connaughton, M. E.

    1981-01-01

    The standard distinction between poetic and referential language, the gulf between science and the humanities, and the distress many teachers of English feel when faced for the first time with the prospect of teaching technical writing are discussed. In the introduction of many technical writing textbooks. Technical communication is divorced from other forms of linguistic experience by making language limiting and reductive rather than creative and expansive. The emphasis on technical/scientific writing as radically different had blinded people to those traits it has in common with all species of composition and has led to a neglect of research, on fundamental rhetorical issues. A complete rhetorical theory of technical discourse should include information about the attitudes and motives of writers, the situations which motivate (or coerce) them to write, definitive features of technical style and form, interrelationship of expression and creativity, and functions of communication in shaping and preserving scientific networds and institutions. The previous areas should be explored with respect to contemporary practice and within an historical perspective.

  13. Multi-Infarct Dementia: A Historical Perspective

    Directory of Open Access Journals (Sweden)

    Erin McKay

    2017-05-01

    Full Text Available Background: Multi-infarct dementia (MID, a prominent subtype of vascular dementia (VaD, has only achieved recognition in the last 4 decades. Since its original description, the characterization, etiological understanding, and therapeutic direction of MID and other VaD subtypes has progressed at an astounding rate. Summary: This paper divides the landmark discoveries and emergence of new research strategies for MID into decade-defining patterns so that a condensed picture of the total history of MID and its eventual inclusion as a VaD subtype emerges. This paper follows the first descriptive decade, a shift to a preventative focus, a renewed interest coinciding with timely advances in research technology, and a hopeful return to treatment possibilities for VaD. Key Message: Concisely tracing the historical lineage of the modern understanding of MID, both as a singular entity and as part of the VaD con­stellation of disorders, provides a novel perspective on the foundation upon which future advances in combating vascular contributions to dementia will be based.

  14. Hormesis and homeopathy: bridge over troubled waters.

    Science.gov (United States)

    Oberbaum, Menachem; Singer, Shepherd Roee; Samuels, Noah

    2010-07-01

    Homeopathy is an empirical method of treatment. Hormesis, while stemming from within the rationalist tradition, has yet to be explained according to current pharmacological theory. Both share in common sub-threshold doses of toxic substances and an initial semi-toxicological insult followed by a greater compensatory (or healing) response. We question whether the differences between these fields may be amenable to scientific research. We identify five cardinal differences between homeopathy and hormesis: (1) Hormesis is a universal phenomenon, while homeopathy is highly specific; (2) Hormesis uses only measurable quantities of compounds, as opposed to homeopathy, which frequently administers medicines at dilutions far beyond the material range; (3) Preparation of hormetic solutions follows standard laboratory procedure, while homeopathy requires a sequential series of dilutions, each followed by vigorous shaking ('succussion'); (4) The effects of hormesis are moderate and temporary, while homeopathy claims curative and permanent responses and (5) Hormesis is a lab phenomenon observed primarily in healthy organisms, whereas homeopathy is a mode of treatment administered primarily to ailing individuals. We believe that all five of these differences are amenable to scientific investigation, and suggest comparing succussed to non-succussed diluted solutions as an optimal first evaluation. We conclude that while certain differences exist between hormesis and homeopathy, hormesis may in fact be a subset of homeopathy.

  15. Bioactive compounds: historical perspectives, opportunities, and challenges.

    Science.gov (United States)

    Patil, Bhimanagouda S; Jayaprakasha, G K; Chidambara Murthy, K N; Vikram, Amit

    2009-09-23

    Mom's conventional wisdom of eating fruits and vegetables to lead a healthy life has evolved with scientific, fact-finding research during the past four decades due to advances in science of "Foods for Health". Epidemiological and prospective studies have demonstrated the vital role of fruits, vegetables, and nuts in reducing the risk of cancer and cardiovascular diseases. In recent years, several meta-analyses strongly suggested that by adding one serving of fruits and vegetables to daily diet, the risk of cardiovascular diseases will be decreased up to 7%. The multidisciplinary and partnership efforts of agriculture and medical scientists across the globe stimulated interest in establishing certain interdisciplinary centers and institutes focusing on "Foods for Health". While the consumption of various healthy foods continues, several questions about toxicity, bioavailability, and food-drug interactions of bioactive compounds are yet to be fully understood on the basis of scientific evidence. Recent research on elucidation of the molecular mechanisms to understand the "proof of the concept" will provide the perfect answer when consumers are ready for a "consumer-to-farm" rather than the current "farm-to-consumer" approach. The multidisciplinary research and educational efforts will address the role of healthy foods to improve eye, brain, and heart health while reducing the risk of cancer. Through this connection, this review is an attempt to provide insight and historical perspectives on some of the bioactive compounds from the day of discovery to their current status. The bioactive compounds discussed in this review are flavonoids, carotenoids, curcumin, ascorbic acid, and citrus limonoids.

  16. Stem cells and bone: a historical perspective.

    Science.gov (United States)

    Bianco, Paolo

    2015-01-01

    Bone physiology and stem cells were tightly intertwined with one another, both conceptually and experimentally, long before the current explosion of interest in stem cells and so-called regenerative medicine. Bone is home to the two best known and best characterized systems of postnatal stem cells, and it is the only organ in which two stem cells and their dependent lineages coordinate the overall adaptive responses of two major physiological systems. All along, the nature and the evolutionary significance of the interplay of bone and hematopoiesis have remained a major scientific challenge, but also allowed for some of the most spectacular developments in cell biology-based medicine, such as hematopoietic stem cell transplantation. This question recurs in novel forms at multiple turning points over time: today, it finds in the biology of the "niche" its popular phrasing. Entirely new avenues of investigation emerge as a new view of bone in physiology and medicine is progressively established. Looking at bone and stem cells in a historical perspective provides a unique case study to highlight the general evolution of science in biomedicine since the end of World War II to the present day. A paradigm shift in science and in its relation to society and policies occurred in the second half of the XXth century, with major implications thereof for health, industry, drug development, market and society. Current interest in stem cells in bone as in other fields is intertwined with that shift. New opportunities and also new challenges arise. This article is part of a Special Issue entitled "Stem cells and bone". Copyright © 2014. Published by Elsevier Inc.

  17. Military Policy toward Homosexuals: Scientific, Historic, and Legal Perspectives

    National Research Council Canada - National Science Library

    Davis, Jeffrey S

    1990-01-01

    This thesis examines military policy toward homosexuals. Scientific, historic, and legal perspectives are reviewed as they relate to current policy and the distinction between homosexual acts and homosexual status...

  18. Library automation in Nigerian universities: a historical perspective ...

    African Journals Online (AJOL)

    Library automation in Nigerian universities: a historical perspective. ... Journal Home > Vol 7, No 2 (2005) > ... others are making some progress along this line while the challenges of library automation are discussed and solutions proposed.

  19. Historical Perspectives in Marketing Education: Justification and Implementation

    Science.gov (United States)

    Petkus, Ed, Jr.

    2010-01-01

    This article provides a justification and an implementation plan for the establishment of a historical orientation across the undergraduate marketing curriculum. The justification for the historical perspective addresses three areas: tapping into the extensive body of knowledge in marketing history, practical implications, and critical thinking.…

  20. Perspectives: Using Historical Documents To Think about NIF Issues.

    Science.gov (United States)

    National Archives and Records Service (GSA), Washington, DC.

    The purpose of using historical documents in the classroom is to generate and enhance discussion by providing a historical perspective for issues. Five documents are included in this packet and are to be used as a supplemental material for the National Issues Forum (NIF) topics. Issues raised include (1) an analysis of the documents and (2)…

  1. Concerns for the Historical Profession: A Liberal Perspective.

    Science.gov (United States)

    Jarausch, Konrad H.

    This paper contends that the debate over multiculturalism in the university is best understood from a broadened historical perspective. The experiences of educational reformers in Germany and the impact of fascism and communism are explored. Based on a historical approach to the multiculturalism debate, three areas of particular concern are…

  2. [Scientific standards in parasitology in historical perspective].

    Science.gov (United States)

    Lonc, Elzbieta; Płonka-Syroka, Bozena

    2005-01-01

    An analysis of scientific standards in parasitology was carried out from the perspective of anthropology of knowledge - a new discipline that emerged from non-classical history science in the 1990s. The history of parasitology, its development and limitations, are presented in a broad socio-cultural context, as the answers of scientists to different social needs in historical periods. In parasitological history there are some periods characteristic for all newly emerging disciplines of natural science. The first systematic account of natural phenomena and their interpretations was initiated in the 16th century and continued till the mid 18th century. It was a period when the phenomena could not be explained in a proper way by the existing and accepted theories. The epidemic diseases were one of these phenomena which were interpreted based on ancient ideas, mostly humoral pathology. In the 16th century a new contagium concept of material factors (pathogenes) that could be spread by contact among humans or close association was formed. This hypothesis, however, was not widely accepted because it contradicted the well-established normative concepts in the European academic naturalism. The development of parasitology was stopped because of theoretical barriers and interpretation difficulties (non-materialistic standard of naturalism, humoral pathology and spontaneous theory). In the second half of the 18th century, the theoretical crisis in natural sciences gave a new impulse for many disciplines; among others, parasitology entered in its second stage of development. The collected observations were classified in a new way and in the context of new interpretations. The progress in parasitology was prompted by the intensified urbanization, rapid increase of European population as well as by wars connected with infections and epidemics. It resulted in two competitive research programs (the French and the German). On the basis of the same observations, they advanced

  3. Toxicological awakenings: the rebirth of hormesis as a central pillar of toxicology

    International Nuclear Information System (INIS)

    Calabrese, Edward J.

    2005-01-01

    This paper assesses historical reasons that may account for the marginalization of hormesis as a dose-response model in the biomedical sciences in general and toxicology in particular. The most significant and enduring explanatory factors are the early and close association of the concept of hormesis with the highly controversial medical practice of homeopathy and the difficulty in assessing hormesis with high-dose testing protocols which have dominated the discipline of toxicology, especially regulatory toxicology. The long-standing and intensely acrimonious conflict between homeopathy and 'traditional' medicine (allopathy) lead to the exclusion of the hormesis concept from a vast array of medical- and public health-related activities including research, teaching, grant funding, publishing, professional societal meetings, and regulatory initiatives of governmental agencies and their advisory bodies. Recent publications indicate that the hormetic dose-response is far more common and fundamental than the dose-response models [threshold/linear no threshold (LNT)] used in toxicology and risk assessment, and by governmental regulatory agencies in the establishment of exposure standards for workers and the general public. Acceptance of the possibility of hormesis has the potential to profoundly affect the practice of toxicology and risk assessment, especially with respect to carcinogen assessment

  4. Teaching Historical Memories in an Intercultural Perspective

    DEFF Research Database (Denmark)

    Scheibel, Katrine Vinther; Wrochem, Oliver

    How can we approach historical remembrance in history teaching? This question lies at the heart of the three-year, EU-funded project TeacMem,which involves partners from Denmark, Germany and Norway. The participants (teacher trainers, historians, teachers, memorial educators, disseminators...

  5. The Amazon Caboclo: Historical and Contemporary Perspectives.

    Science.gov (United States)

    Parker, Eugene Philip, Ed.

    1985-01-01

    This collection of papers provides a general sketch of the events and processes leading to the evolution and development of Caboclo culture in the Amazonia region of South America. Following the foreword and introduction, the book is divided into two parts. Part one contains historical background about the period from 1615 to 1920 within three…

  6. Indian Women: An Historical and Personal Perspective

    Science.gov (United States)

    Christensen, Rosemary Ackley

    1975-01-01

    Several issues relating to Indian women are discussed. These include (1) the three types of people to whom we owe our historical perceptions of Indian women, (2) role delineation in Indian society; (3) differences between Indian women and white women, and (4) literary role models of Indian women. (Author/BW)

  7. Robotic Autonomous Observatories: A Historical Perspective

    Directory of Open Access Journals (Sweden)

    Alberto Javier Castro-Tirado

    2010-01-01

    Full Text Available This paper presents a historical introduction to the field of Robotic Astronomy, from the point of view of a scientist working in this field for more than a decade. The author discusses the basic definitions, the differing telescope control operating systems, observatory managers, as well as a few current scientific applications.

  8. Putting Barack Obama's Candidacy in Historical Perspective

    Science.gov (United States)

    Rogers, Ibram

    2008-01-01

    Senator Barack Obama's historic candidacy for president of the United States has generated an intense and thoughtful national discussion within Black America. His campaign has brought several issues to the fore. Recently, the author spoke with five of the most preeminent Black scholars in the nation to search out some of their thoughts on five key…

  9. A stochastic model of hormesis

    International Nuclear Information System (INIS)

    Yakovlev, A.Yu.; Tsodikov, A.D.; Bass, L.

    1993-01-01

    In order to describe the life-prolonging effect of some agents that are harmful at higher doses, ionizing radiations in particular, a stochastic model is developed in terms of accumulation and progression of intracellular lesions caused by the environment and by the agent itself. The processes of lesion repair, operating at the molecular and cellular level, are assumed to be responsible for this hormesis effect within the framework of the proposed model. Properties of lifetime distributions, derived for analysis of animal experiments with prolonged and acute irradiation, are given special attention. The model provides efficient means of interpreting experimental findings, as evidenced by its application to analysis of some published data on the hormetic effects of prolonged irradiation and of procaine on animal longevity. 51 refs., 2 figs., 1 tabs

  10. Artificial Heart Research: An Historical Perspective

    OpenAIRE

    Joshi, Rayan

    2001-01-01

    This paper tracks the historical evolution of artificial heart technology, from its humble beginnings, to its relatively staggering current potential. While examining various milestones along this fascinating timeline, the paper attempts to shed light on some of the ethical, economic, and social dilemmas that have infused this history. In doing so, it strives to provide the reader with a sense of the various factors, some technical in nature and others purely societal, that have wielded influ...

  11. LWR control assembly designs: A historical perspective

    International Nuclear Information System (INIS)

    Kennard, M.W.; Harbottle, J.E.

    2000-01-01

    Control rod designs and materials have evolved in response to performance problems in both PWRs and BWRs. Irradiation-assisted stress corrosion cracking (IASCC) due to absorber swelling has primarily affected BWR control rods with B 4 C absorbers, but has also occurred in PWRs with Ag-In-Cd absorbers. The primary problems for some designs of PWR control rods have been wear of the rodlets against upper internal components and swelling with tip wear and cracking. Competition amongst vendors for supplying control rod reloads has also resulted in design improvements. This paper provides an historical review of PWR and BWR control rod designs, their problems and remedies. (author)

  12. Radiation risk - historical perspective and current issues

    Energy Technology Data Exchange (ETDEWEB)

    Kellerer, Albrecht M. [Strahlenbiologisches Institut, Ludwig-Maximilians-Universitaet, Munich, Germany and Institute for Radiation Biology, GSF-National Research Center for Environment and Health, Neuherberg (Germany)

    2002-09-01

    The assessment of radiation risk needs to be seen against the background of a historical development that has reversed the initial belief in a general beneficial effect of radiation to apprehension and fear. Numerical risk estimates are, today, based on large epidemiological studies, and the observations on the A-bomb survivors are outlined as the primary source of information. Since the epidemiological findings are obtained from relatively high radiation exposures, extrapolations are required to the much lower doses that are relevant to radiation protection. The evolution of extrapolation procedures up to current attempts at mechanistic modelling is outlined, and some of the open issues are reviewed. (author)

  13. Radiation risk - historical perspective and current issues

    International Nuclear Information System (INIS)

    Kellerer, Albrecht M.

    2002-01-01

    The assessment of radiation risk needs to be seen against the background of a historical development that has reversed the initial belief in a general beneficial effect of radiation to apprehension and fear. Numerical risk estimates are, today, based on large epidemiological studies, and the observations on the A-bomb survivors are outlined as the primary source of information. Since the epidemiological findings are obtained from relatively high radiation exposures, extrapolations are required to the much lower doses that are relevant to radiation protection. The evolution of extrapolation procedures up to current attempts at mechanistic modelling is outlined, and some of the open issues are reviewed. (author)

  14. Academic Entrepreneurship and Institutional Change in Historical Perspective

    DEFF Research Database (Denmark)

    Wadhwani, R. Daniel; Galvez-Behar, Gabriel; Mercelis, Joris

    2017-01-01

    This article provides a historical perspective on academic entrepreneurship and its role in institutional change, and serves as an introduction to a special issue devoted to the subject. Unlike approaches that define academic entrepreneurship narrowly as the commercialization of academic research...

  15. Learning Spiritual Dimensions of Care from a Historical Perspective.

    Science.gov (United States)

    Narayanasamy, Aru

    1999-01-01

    Looks at the spiritual dimensions of nursing at various historical periods: ancient civilizations, the Middle Ages, Renaissance, and the 18th and 19th centuries. Reviews contemporary perspectives on spirituality and nursing and suggests how nurses can be equipped to deal with patients' spiritual needs. (SK)

  16. Biomolecular simulation: historical picture and future perspectives.

    Science.gov (United States)

    van Gunsteren, Wilfred F; Dolenc, Jozica

    2008-02-01

    Over the last 30 years, computation based on molecular models is playing an increasingly important role in biology, biological chemistry and biophysics. Since only a very limited number of properties of biomolecular systems are actually accessible to measurement by experimental means, computer simulation complements experiments by providing not only averages, but also distributions and time series of any definable, observable or non-observable, quantity. Biomolecular simulation may be used (i) to interpret experimental data, (ii) to provoke new experiments, (iii) to replace experiments and (iv) to protect intellectual property. Progress over the last 30 years is sketched and perspectives are outlined for the future.

  17. Women and drug addiction: a historical perspective.

    Science.gov (United States)

    Kandall, Stephen R

    2010-04-01

    The history of women and addiction in America extends back more than 150 years. Although the true epidemiology of women and addiction has always been difficult to determine, the spectrum of female addicts extends well beyond those women who make sensationalistic headlines by "abandoning" or "battering" their children. Historically, female addiction has been largely the result of inappropriate overmedication practices by physicians and pharmacists, media manipulation, or individuals own attempts to cope with social or occupational barriers preventing equality and self-fulfillment. From the mid-nineteenth century, uneasy tolerance, social ostracism, vilification, persecution, and legal prosecution have grudgingly, but not completely, given way to more humane treatment opportunities in the setting of more enlightened comprehensive care.

  18. The population health approach in historical perspective.

    Science.gov (United States)

    Szreter, Simon

    2003-03-01

    The origin of the population health approach is an historic debate over the relationship between economic growth and human health. In Britain and France, the Industrial Revolution disrupted population health and stimulated pioneering epidemiological studies, informing the early preventive public health movement. A century-long process of political adjustment between the forces of liberal democracy and propertied interests ensued. The 20th-century welfare states resulted as complex political mechanisms for converting economic growth into enhanced population health. However, the rise of a "neoliberal" agenda, denigrating the role of government, has once again brought to the fore the importance of prevention and a population health approach to map and publicize the health impacts of this new phase of "global" economic growth.

  19. Radiation hormesis at occupational exposure

    International Nuclear Information System (INIS)

    Georgieva, R.; Rupova, I.; Zaharieva, E.; Acheva, A.

    2007-01-01

    Complete text of publication follows. Objective: The idea in favour of the auspicious effect of low dose ionizing radiation in biological systems exists for years and serves as basis of the radiation hormesis hypothesis. The results in support of this phenomenon are not accepted as reliable by ICRP. The available epidemiological data could only suppose the presence of hormetic effect because of statistics limitations and relatively high spontaneous rate of the examined effects. The present work was aimed at finding appropriate biomarkers applicable in molecular epidemiological surveys of occupationally exposed individuals and/or population to prove radiation hormesis. Methods: Blood samples were taken from more than 400 NPP workers, divided in two groups: from the 'strict regimen' area (exposed) and from the administration staff (control). Two levels of evaluation were used: 1) molecular - spontaneous and induced DNA repair by UDS, protein synthesis evaluated radio-metrically, DNA damage by SCGE - all of them in white blood cells, concentration of malonedialdehyde in blood serum; and 2) cellular - the Ly-subsets by flow cytometry, using a FacScan analyzer and immunofluorescent stained mouse monoclonal antibodies. Results: A significant decrease of potentially lethal damage was found in persons with 'mean annual dose' lower or equal to 5 mSv/a, compared to the control group. The highest repair capacity after a challenging dose of 2,0 Gy gamma rays as well as a significant decrease in the level of oxidative stress was evaluated for persons from the same group. At doses below 200 mSv statistically different decrease of the index of CD3+4+, CD4+25+, CD4+62L+ lymphocyte populations and CD4/CD8 cell ratio was established, and increased levels of NK cells, CD57+8+ , CD8+28+ and CD8+38 were recorded. Conclusion: The present investigation showed that annual doses lower than twice the natural radiation background exert positive effects on DNA damage and repair, increase

  20. The AIDS pandemic in historic perspective.

    Science.gov (United States)

    Kazanjian, Powel

    2014-07-01

    Potent antiretroviral drugs (ART) have changed the nature of AIDS, a once deadly disease, into a manageable illness and offer the promise of reducing the spread of HIV. But the pandemic continues to expand and cause significant morbidity and devastation to families and nations as ART cannot be distributed worldwide to all who need the drugs to treat their infections, prevent HIV transmission, or serve as prophylaxis. Furthermore, conventional behavioral prevention efforts based on theories that individuals can be taught to modify risky behaviors if they have the knowledge to do so have been ineffective. Noting behavioral strategies targeting individuals fail to address broader social and political structures that create environments vulnerable to HIV spread, social scientists and public health officials insist that HIV policies must be comprehensive and also target a variety of structures at the population and environmental level. Nineteenth-century public health programs that targeted environmental susceptibility are the historical analogues to today's comprehensive biomedical and structural strategies to handle AIDS. Current AIDS policies underscore that those fighting HIV using scientific advances in virology and molecular biology cannot isolate HIV from its broader environment and social context any more than their nineteenth-century predecessors who were driven by the filth theory of disease. © The Author 2012. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  1. Europe of electricity. An historical perspective

    International Nuclear Information System (INIS)

    Bouttes, Jean-Paul; DASSA, Francois

    2016-11-01

    The authors propose a perspective on the history of electricity in Europe which notably illustrates both similarities and differences between models and policies in European countries. In a first part, they address the early years of electricity development, between 1880 and 1920, which drove the whole European society and economy. They analyse this success as based on three main issues: a common vision of the role of electricity in the society (a symbol of progress and modernity), a collective work on the technical and economic reality (a community of scientists and engineers working on technological breakthroughs), and propositions regarding institutions and the activity organisation (a common industrial model elaborated by contractors-managers of the electricity sector and proposed to governments). In a second part, the authors address the following period (1920-1980) which is characterized by a diversity of models for the electricity sectors and systems. They highlight the background of these differences, propose a focus on the three main European countries (France, Germany, Great-Britain), and discuss the relationship between this diversity of organisation modes and imageries. The next part addresses the Europe of electricity since the 1980's. The authors outline its technical characteristic, the adoption of a top-down approach since the 1990's, and the lack of consistency in these evolutions, and draw some lessons from the building up of a Europe of electricity since the 1990's. The authors finally question and comment how to build up the Europe of energy again

  2. Heart rate variability - a historical perspective.

    Science.gov (United States)

    Billman, George E

    2011-01-01

    Heart rate variability (HRV), the beat-to-beat variation in either heart rate or the duration of the R-R interval - the heart period, has become a popular clinical and investigational tool. The temporal fluctuations in heart rate exhibit a marked synchrony with respiration (increasing during inspiration and decreasing during expiration - the so called respiratory sinus arrhythmia, RSA) and are widely believed to reflect changes in cardiac autonomic regulation. Although the exact contributions of the parasympathetic and the sympathetic divisions of the autonomic nervous system to this variability are controversial and remain the subject of active investigation and debate, a number of time and frequency domain techniques have been developed to provide insight into cardiac autonomic regulation in both health and disease. It is the purpose of this essay to provide an historical overview of the evolution in the concept of HRV. Briefly, pulse rate was first measured by ancient Greek physicians and scientists. However, it was not until the invention of the "Physician's Pulse Watch" (a watch with a second hand that could be stopped) in 1707 that changes in pulse rate could be accurately assessed. The Rev. Stephen Hales (1733) was the first to note that pulse varied with respiration and in 1847 Carl Ludwig was the first to record RSA. With the measurement of the ECG (1895) and advent of digital signal processing techniques in the 1960s, investigation of HRV and its relationship to health and disease has exploded. This essay will conclude with a brief description of time domain, frequency domain, and non-linear dynamic analysis techniques (and their limitations) that are commonly used to measure HRV.

  3. Heart Rate Variability - A Historical Perspective

    Directory of Open Access Journals (Sweden)

    George E Billman

    2011-11-01

    Full Text Available Heart rate variability (HRV, the beat-to-beat variation in either heart rate or the duration of the R-R interval – the heart period, has become a popular clinical and investigational tool. The temporal fluctuations in heart rate exhibit a marked synchrony with respiration (increasing during inspiration and decreasing during expiration – the so called respiratory sinus arrhythmia, RSA and are widely believed to reflect changes in cardiac autonomic regulation. Although the exact contributions of the parasympathetic and the sympathetic divisions of the autonomic nervous system to this variability are controversial and remain the subject of active investigation and debate, a number of time and frequency domain techniques have been developed to provide insight into cardiac autonomic regulation in both health and disease. It is the purpose of this essay to provide an historical overview of the evolution in the concept of heart rate variability. Briefly, pulse rate was first measured by ancient Greek physicians and scientists. However, it was not until the invention of the Physician’s Pulse Watch (a watch with a second hand that could be stopped in 1707 that changes in pulse rate could be accurately assessed. The Rev. Stephen Hales (1733 was the first to note that pulse varied with respiration and in 1847 Carl Ludwig was the first to record RSA. With the measurement of the ECG (1895 and advent of digital signal processing techniques in the 1960’s, investigation of HRV and its relationship to health and disease has exploded. This essay will conclude with a brief description of time domain, frequency domain, and non-linear dynamic analysis techniques (and their limitations that are commonly used to measure heart rate variability.

  4. A historical perspective on ventilator management.

    Science.gov (United States)

    Shapiro, B A

    1994-02-01

    Paralysis via neuromuscular blockade in ICU patients requires mechanical ventilation. This review historically addresses the technological advances and scientific information upon which ventilatory management concepts are based, with special emphasis on the influence such concepts have had on the use of neuromuscular blocking agents. Specific reference is made to the scientific information and technological advances leading to the newer concepts of ventilatory management. Information from > 100 major studies in the peer-reviewed medical literature, along with the author's 25 yrs of clinical experience and academic involvement in acute respiratory care is presented. Nomenclature related to ventilatory management is specifically defined and consistently utilized to present and interpret the data. Pre-1970 ventilatory management is traced from the clinically unacceptable pressure-limited devices to the reliable performance of volume-limited ventilators. The scientific data and rationale that led to the concept of relatively large tidal volume delivery are reviewed in the light of today's concerns regarding alveolar overdistention, control-mode dyssynchrony, and auto-positive end-expiratory pressure. Also presented are the post-1970 scientific rationales for continuous positive airway pressure/positive end-expiratory pressure therapy, avoidance of alveolar hyperxia, and partial ventilatory support techniques (intermittent mandatory ventilation/synchronized intermittent mandatory ventilation). The development of pressure-support devices is discussed and the capability of pressure-control techniques is presented. The rationale for more recent concepts of total ventilatory support to avoid ventilator-induced lung injury is presented. The traditional techniques utilizing volume-preset ventilators with relatively large tidal volumes remain valid and desirable for the vast majority of patients requiring mechanical ventilation. Neuromuscular blockade is best avoided in these

  5. Radiation hormesis at occupational exposure

    International Nuclear Information System (INIS)

    Zaharieva, E.; Georgieva, R.

    2006-01-01

    Full text: The aim of our work was to find appropriate biomarkers applicable in molecular epidemiological surveys of occupationally exposed individuals to prove radiation hormesis. Blood samples were taken from a group of irradiated persons, and from a control group. For each worker we estimated a parameter arbitrarily called by us 'mean annual dose' as a quotient of cumulated dose and length of service. DNA repair synthesis in leucocytes before and after in vitro exposure to a challenge dose of 2.0 Gy gamma rays was determined by the level of incorporation of radioactively labeled nucleotides, level of DNA damage in lymphocytes was analyzed by single cell gel electrophoresis and level of lipid peroxidation processes was evaluated by malonedialdehyde concentration in blood plasma. A significant decrease of potentially lethal damage in persons with 'mean annual dose' lower or equal to 5 mSv/y was found, compared to the control group. The highest repair capacity after a challenging dose of 2.0 Gy gamma rays as well as a significant decrease in the level of oxidative stress determined in the blood plasma was evaluated for persons from the same group. The present investigation of occupationally exposed workers showed that annual doses no higher than twice the natural radiation background exert positive effects on DNA damage and repair, increase cellular resistance and decrease oxidative stress

  6. Unequal brothers : are homeopathy and hormesis linked?

    Science.gov (United States)

    Oberbaum, Menachem; Frass, Michael; Gropp, Cornelius

    2015-04-01

    The debate between those who believe homeopathy and hormesis derive from the same root and those who believe the two are different phenomena is as old as hormesis. It is an emotionally loaded discussion, with both sides fielding arguments which are far from scientific. Careful analysis of the basic paradigms of the two systems questions the claim of the homeopaths, who find similarities between them. The authors discuss these paradigms, indicating the differences between the claims of homeopathy and hormesis. It is time for thorough and serious research to lay this question to rest. One possible approach is to compare the activity of a hormetic agent, prepared in the usual way, with that of the same agent in the same concentration prepared homeopathically by serial dilution and succussion. Copyright © 2015. Published by Elsevier Ltd.

  7. Poverty, Population, Inequality, and Development: the Historical Perspective

    Directory of Open Access Journals (Sweden)

    Chilosi, Alberto

    2010-12-01

    Full Text Available Seen in historical perspective the main economic predicaments of the present world (such as poverty, inequality, backwardness appear in a somewhat different light than in many current discussions, especially by sociologists, radical economists and political scientists. In the present paper the achievements of the modern age, and in particular of the post- World War II period, are considered in the perspective of economic and demographic history, and in their connection with the systems of production and of international relations. Some considerations concerning future possible developments conclude the paper.

  8. Physics Education Research in Perspective: An Historical and Conceptual Overview

    Science.gov (United States)

    Meltzer, David E.

    2011-04-01

    I will discuss the evolution of physics education research (PER) within an historical perspective that begins in the 1860s, focuses on developments in the post-World War II period, and extends towards diverse future pathways. PER has incorporated a broad array of themes that resonate with past developments in science education; however, it also provides unique perspectives that offer promise of potential breakthroughs in areas previously underexplored. Nonetheless, there is a long road from promise to realization, and I will try to identify key aspects of past accomplishments as well as of present and future challenges. Supported in part by NSF PHY-0108787 and DUE-0817282.

  9. Science and technology from global and historical perspectives

    CERN Document Server

    Karagözoğlu, Bahattin

    2017-01-01

    This book provides science and technology ethos to a literate person. It starts with a rather detailed treatment of basic concepts in human values, educational status and domains of education, development of science and technology and their contributions to the welfare of society. It describes ways and means of scientific progresses and technological advancements with their historical perspectives including scientific viewpoints of contributing scientists and technologists. The technical, social, and cultural dimensions are surveyed in relation to acquisition and application of science, and advantages and hindrances of technological developments. Science and Technology is currently taught as a college course in many universities with the intention to introduce topics from a global historical perspective so that the reader shall stretch his/her vision by mapping the past to the future. The book can also serve as a primary reference for such courses.

  10. Historical perspective of thermal reactor safety in light water reactors

    International Nuclear Information System (INIS)

    Levy, S.

    1986-01-01

    A brief history of thermal reactor safety in U.S. light water reactors is provided in this paper. Important shortcomings in safety philosophy evolution versus time are identified and potential corrective actions are suggested. It should be recognized, that this analysis represents only one person's opinion and that most historical accountings reflect the author's biases and specific areas of knowledge. In that sense, many of the examples used in this paper are related to heat transfer and fluid flow safety issues, which explains why it has been included in a Thermal Hydraulics session. One additional note of caution: the value of hindsight and the selective nature of human memory when looking at the past cannot be overemphasized in any historical perspective

  11. Historical perspectives on theories of periodontal disease etiology

    DEFF Research Database (Denmark)

    Hujoel, Philippe; Zina, Lívia Guimarães; Cunha-Cruz, Joana

    2012-01-01

    Our understanding of the causes of periodontal disease have changed greatly over time. The aim of this review is to provide a critical and historical perspective, dating back over more than a century, on two competing paradigms. While we understand that this stark dichotomization may be viewed...... as extreme, and is legitimately open to challenge, it is our hope that this didactic approach will serve to stimulate debate. The distinction made focuses on whether the primary etiology involves local causes, such as dental plaque, or involves remote causes, such as nutrition, tobacco use or other systemic...... factors. We provide a brief historical overview of the local and remote cause hypotheses and discuss some key reasons why the local cause hypothesis has become dominant....

  12. Hospital and asylum visiting in historical perspective: themes and issues.

    Science.gov (United States)

    Mooney, Graham; Reinarz, Jonathan

    2009-01-01

    Compared to doctors, patients and institutions, visitors are an understudied constituency in medical history. The collection of essays in this book situates the historical practice of hospital and asylum visiting in broad social, cultural and geographical perspectives. This introduction loosely categorises visitors into four groups: patient visitors, including family and friends; public visitors, such as entertainers, tourists and the clergy, who have no direct formal ties with the institution or the patients; house visitors involved with the management and government of the hospital; and official visitors, who have inspectorial responsibilities. Discussion of the wider historical significance of visiting draws attention to issues such as urban governance, philanthropy, the public sphere, civil society and citizenship.

  13. The concept of learning in cultural-historical perspective

    DEFF Research Database (Denmark)

    Chaiklin, Seth

    2015-01-01

    their implications for understanding learning. Brief comments are made about the notions of internalization and zone of proximal development. Subsequent theoretical developments are mentioned, with a special focus on the idea of learning activity and developmental teaching. The chapter concludes with three issues......A cultural-historical perspective on learning is presented. The key idea is to conceptualise learning as self-mastery of action, using existing psychological functions. The main part of the chapter provides an overview of Vygotsky’s theory of higher psychological functions, and discusses...

  14. Historic perspectives from anthropology. Reflections proposed to Transcultural Nursing.

    Science.gov (United States)

    Rohrbach Viadas, Cecilia

    2015-01-01

    History brings together meanings related to earlier periods, being aware of the past as a panorama to reread the present. Madeleine Leininger presented in 1970 an implicit and respectful message to the Nursing Profession when introducing Nursing and Anthropology. Two Worlds to Blend. Implicitly: Nursing you disregard culture. This article shows the absence of the history of anthropology and of nursing within Transcultural Nursing and it includes how education has influenced theoretic, methodological, and comparative approaches giving researchers the responsibility to decide their fundamentals. Berthoud (2001) has inspired the anthropological and historic perspectives of the author, thus universalism, relativism, and comparison are presented.

  15. Separations chemistry for f elements: Recent developments and historical perspective

    International Nuclear Information System (INIS)

    Nash, K.L.; Choppin, G.R.

    1995-01-01

    With the end of the cold war, the principal mission in actinide separations has changed from production of plutonium to cleanup of the immense volume of moderately radioactive mixed wastes which resulted from fifty years of processing activities. In order to approach the cleanup task from a proper perspective, it is necessary to understand the nature of the problem and how the wastes were generated. In this report, the history of actinide separations, both the basic science and production aspects, is examined. Many of the separations techniques in use today were developed in the 40's and 50's for the identification and production of actinide elements. To respond to the modern world of actinide separations new techniques are being developed for separations ranging from analytical methods to detect ultra-trace concentrations (for bioassay and environmental monitoring) to large scale waste treatment procedures. Some of these new methods are ''improvements'' or adaptations of the historical techniques. Total actinide recovery, lanthanide/actinide separations, and selective partitioning of actinides from inert constituents are of primary concern. This report, offers a historical perspective, review the current status of f element separation processes, and suggest areas for continued research in both actinide separations and waste cleanup/environment remediation

  16. Homeopathy: clarifying its relationship to hormesis.

    Science.gov (United States)

    Calabrese, Edward J; Jonas, Wayne B

    2010-07-01

    This paper presents the case that certain types of homeopathic medicine may represent a form of hormesis, that is, either pre- or post-conditioning hormesis. An example of a post-conditioning model by van Wijk and colleagues demonstrated successful enhancement of adaptive responses using below-toxic threshold doses (i.e. hormetic doses) of inducing agents when administered subsequent to a highly toxic chemical exposure, thus satisfying a basic experimental biomedical standard. Of note is that this model uses exposures within a measurable predicted hormetic range, unlike most forms of homeopathy. This experimental framework (along with a pre-conditioning model developed by Bellavite) provides a possible vehicle by which certain aspect(s) of homeopathy may be integrated into mainstream biomedical assessment and clinical practice.

  17. Research status on radiation hormesis at CRIEPI

    International Nuclear Information System (INIS)

    Hattori, Sadao

    1996-01-01

    In 1982, Thomas D. Luckey, Prof. Emeritus, University of Missouri published a paper on radiation hormesis. His emphasis was on the beneficial effects of low-level radiation contributing to a healthy body, longer life, vitalization, etc. Radiation hormesis research by the Central Research Institute of Electric Power Industry in Japan was initiated on the rationale that if Luckey's claim were true, radiation management in Japan was extremely erroneous and the research institutes had to determine the truth. Obtaining many test results from some human data and various animal experiments on the health effects of low-level radiation that support the radiation hormesis hypothesis, the Central Research Institute decided to expand their research activities into a collaborative testing program with 14 universities and 2 other institutes on various subjects. The subjects in which they are now interested are as follows: 1. enhancement of molecular biological activities such as gene repair and apoptosis by low-level radiation; 2. enhancement of the immune system such as the ratio of Helper T cell/Suppressor T cell by low-level radiation; 3. rejuvenation such as cell membrane permeability, superoxide dismutase activity, and the therapy of old-age diseases such as diabetes and high blood pressure

  18. Statistical methods and applications from a historical perspective selected issues

    CERN Document Server

    Mignani, Stefania

    2014-01-01

    The book showcases a selection of peer-reviewed papers, the preliminary versions of which were presented at a conference held 11-13 June 2011 in Bologna and organized jointly by the Italian Statistical Society (SIS), the National Institute of Statistics (ISTAT) and the Bank of Italy. The theme of the conference was "Statistics in the 150 years of the Unification of Italy." The celebration of the anniversary of Italian unification provided the opportunity to examine and discuss the methodological aspects and applications from a historical perspective and both from a national and international point of view. The critical discussion on the issues of the past has made it possible to focus on recent advances, considering the studies of socio-economic and demographic changes in European countries.

  19. The case of James A. Garfield: a historical perspective.

    Science.gov (United States)

    Weiner, Bradley K

    2003-05-15

    In 1881, President James A. Garfield was shot in the back and died 79 days later. During this time, many controversies arose that had repercussions for years to come. Who was to manage the President's care? A prominent local physician took on the case, but after Garfield's death, he was highly criticized for inappropriate care and for excluding more highly qualified surgeons. Where was the bullet? Multiple opinions were given including that of Alexander Graham Bell. The correct suggestion turned out to be that of a young, unknown assistant demonstrator of anatomy. What was the proper treatment? Local wound care, removal of the bullet, and laparotomy all were considered. Many have felt that the choice of treatment may have proved to be worse than the injury itself. What did the autopsy show? Even this was controversial, with different observers claiming different results. This historical perspective reviews the case as well the controversies that surrounded it.

  20. Of Marx and Makers: an Historical Perspective on Generative Justice

    Directory of Open Access Journals (Sweden)

    Ron Eglash

    2016-06-01

    Full Text Available In Marxist frameworks “distributive justice” depends on extracting value through a centralized state. Many new social movements—peer to peer economy, maker activism, community agriculture, queer ecology, etc.—take the opposite approach, keeping value in its unalienated form and allowing it to freely circulate from the bottom up. Unlike Marxism, there is no general theory for bottom-up, unalienated value circulation. This paper examines the concept of “generative justice” through an historical contrast between Marx’s writings and the indigenous cultures that he drew upon. Marx erroneously concluded that while indigenous cultures had unalienated forms of production, only centralized value extraction could allow the productivity needed for a high quality of life. To the contrary, indigenous cultures now provide a robust model for the “gift economy” that underpins open source technological production, agroecology, and restorative approaches to civil rights. Expanding Marx’s concept of unalienated labor value to include unalienated ecological (nonhuman value, as well as the domain of freedom in speech, sexual orientation, spirituality and other forms of “expressive” value, we arrive at an historically informed perspective for generative justice. 

  1. Historic perspective: prebiotics, probiotics, and other alternatives to antibiotics.

    Science.gov (United States)

    Hume, M E

    2011-11-01

    Applications of antimicrobials in food production and human health have found favor throughout human history. Antibiotic applications in agricultural and human medical arenas have resulted in tremendous increases in food animal production and historically unprecedented gains in human health protection. Successes attributed to widespread antibiotic use have been accompanied by the inadvertent emergence of antibiotic-resistant bacteria. A major problem associated with this emerging resistance is the crossover use of some antibiotics in agricultural settings as well as in the prevention and treatment of human disease. This outcome led to calls to restrict the use of human health-related antibiotics in food animal production. Calls for restricted antibiotic use have heightened existing searches for alternatives to antibiotics that give similar or enhanced production qualities as highly reliable as the antibiotics currently provided to food animals. Agricultural and scientific advances, mainly within the last 100 yr, have given us insights into sources, structures, and actions of materials that have found widespread application in our modern world. The purpose of this presentation is to provide a historic perspective on the search for what are generally known as antibiotics and alternative antimicrobials, probiotics, prebiotics, bacteriophages, bacteriocins, and phytotherapeutics.

  2. RACK(1) to the future - a historical perspective

    LENUS (Irish Health Repository)

    Ron, Dorit

    2013-08-01

    This perspective summarises the first and long overdue RACK1 meeting held at the University of Limerick, Ireland, May 2013, in which RACK1’s role in the immune system, the heart and the brain were discussed and its contribution to disease states such as cancer, cardiac hypertrophy and addiction were described. RACK1 is a scaffolding protein and a member of the WD repeat family of proteins. These proteins have a unique architectural assembly that facilitates protein anchoring and the stabilisation of protein activity. A large body of evidence is accumulating which is helping to define the versatile role of RACK1 in assembling and dismantling complex signaling pathways from the cell membrane to the nucleus in health and disease. In this commentary, we first provide a historical perspective on RACK1. We also address many of the pertinent and topical questions about this protein such as its role in transcription, epigenetics and translation, its cytoskeletal contribution and the merits of targeting RACK1 in disease.

  3. Camelid Single-Domain Antibodies: Historical Perspective and Future Outlook

    Directory of Open Access Journals (Sweden)

    Mehdi Arbabi-Ghahroudi

    2017-11-01

    Full Text Available Tremendous effort has been expended over the past two and a half decades to understand many aspects of camelid heavy chain antibodies, from their biology, evolution, and immunogenetics to their potential applications in various fields of research and medicine. In this article, I present a historical perspective on the development of camelid single-domain antibodies (sdAbs or VHHs, also widely known as nanobodies since their discovery and discuss the advantages and disadvantages of these unique molecules in various areas of research, industry, and medicine. Commercialization of camelid sdAbs exploded in 2001 with a flurry of patents issued to the Vrije Universiteit Brussel (VUB and later taken on by the Vlaams Interuniversitair Instituut voor Biotechnologie (VIB and, after 2002, the VIB-founded spin-off company, Ablynx. While entrepreneurial spirit has certainly catalyzed the exploration of nanobodies as marketable products, IP restrictions may be partially responsible for the relatively long time span between the discovery of these biomolecules and their entry into the pharmaceutical market. It is now anticipated that the first VHH-based antibody drug, Caplacizumab, a bivalent anti-vWF antibody for treating rare blood clotting disorders, may be approved and commercialized in 2018 or shortly thereafter. This elusive first approval, along with the expiry of key patents, may substantially alter the scientific and biomedical landscape surrounding camelid sdAbs and pave the way for their emergence as mainstream biotherapeutics.

  4. Crisis discussions in psychology--New historical and philosophical perspectives.

    Science.gov (United States)

    Sturm, Thomas; Mülberger, Annette

    2012-06-01

    In this introductory article, we provide a historical and philosophical framework for studying crisis discussions in psychology. We first trace the various meanings of crisis talk outside and inside of the sciences. We then turn to Kuhn's concept of crisis, which is mainly an analyst's category referring to severe clashes between theory and data. His view has also dominated many discussions on the status of psychology: Can it be considered a "mature" science, or are we dealing here with a pre- or multi-paradigmatic discipline? Against these Kuhnian perspectives, we point out that especially, but not only in psychology distinctive crisis declarations and debates have taken place since at least the late 19th century. In these, quite different usages of crisis talk have emerged, which can be determined by looking at (a) the content and (b) the dimensions of the declarations, as well as (c) the functions these declarations had for their authors. Thus, in psychology at least, 'crisis' has been a vigorous actor's category, occasionally having actual effects on the future course of research. While such crisis declarations need not be taken at face value, they nevertheless help to break the spell of Kuhnian analyses of psychology's history. They should inform ways in which the history and philosophy of psychology is studied further. Copyright © 2011 Elsevier Ltd. All rights reserved.

  5. Neutron activation analysis of trace elements in Japanese hormesis cosmetics

    International Nuclear Information System (INIS)

    Furuta, E.; Nakahara, H.; Hatsukawa, Y.; Matsue, H.; Sakane, H.

    2008-01-01

    In Japan, cosmetics claiming hormesis effect are available through Internet. Although these cosmetics show the contents, they never mention the minor elements and radioactive sources. The existence of radioisotopes, however, was observed by measurements of the gamma-rays with a HPGe detector. In this study, in order to clarify the contents of trace elements, the hormesis cosmetics including radioactive sources were analyzed using INAA, PGAA and NAA with multiple gamma-ray detection (NAAMG). Nineteen elements were analyzed quantitatively in hormesis cosmetics by INAA, PGAA and NAAMG and 16 elements were detected qualitatively by SEM-EPMA. (author)

  6. Review of retrofit strategies decision system in historic perspective

    Directory of Open Access Journals (Sweden)

    M. D. Bostenaru Dan

    2004-01-01

    Full Text Available Urban development is a process. In structuring and developing its phases different actors are implied, who act under different, sometimes opposite, dynamic conditions and within different reference systems. This paper aims to explore the contribution of participatism to disaster mitigation, when this concerns earthquake impact on urban settlements, through the support provided to multi-criteria decision in matters of retrofit. The research broadness in field of decision making on one side and the lack of a specific model for the retrofit of existing buildings on another side led to an extensive review of the state of the art in related models to address the issue. Core idea in the selection of existing models has been the preoccupation for collaborative issues, in other words, the consideration for the different actors implied in the planning process. The historic perspective on participative planning models is made from the view of two generations of citizen implication. The first approaches focus on the participation of the building owner/inhabitant in the planning process of building construction. As current strategies building rehabilitation and selection from alternative retrofit strategies are presented. New developments include innovative models using the internet or spatial databases. The investigated participation approaches show, that participation and communication as a more comprehensive term are an old topic in the field politics-democratisation-urbanism. In all cases it can be talked of 'successful learning processes', of the improvement of the level of the professional debate. More than 30 years history of participation marked a transition in understanding the concept: from participation, based on a central decision process leading to a solution controlled and steered by the political-administrative system, to communication, characterised by simultaneous decision processes taking place outside politics and administration in co

  7. Prospects for tobacco control in Zimbabwe: a historical perspective.

    Science.gov (United States)

    Woelk, G; Mtisi, S; Vaughan, J P

    2001-09-01

    Using a historical and political economy perspective, this paper explores the prospects for tobacco control in Zimbabwe, the world's sixth largest producer and third largest tobacco exporter. Tobacco production, which first began in the former Rhodesia in the early 1900s, is closely associated with colonial history and land occupation by white settlers. The Zimbabwe (formerly Rhodesia) Tobacco Association was formed in 1928 and soon became a powerful political force. Although land redistribution has always been a central issue, it was not adequately addressed after independence in 1980, largely due to the need for Zimbabwe to gain foreign currency and safeguard employment. However, by the mid-1990s political pressures forced the government to confront the mainly white, commercial farmers with a new land acquisition policy, but intense national and international lobbying prevented its implementation. With advent of global economic changes, and following the start of a structural adjustment programme in 1991, manufacturing began to decline and the government relied even more on the earnings from tobacco exports. Thus strengthening tobacco control policies has always had a low national and public health priority. Recent illegal occupation of predominantly white owned farms, under the guise of implementing the former land redistribution policy, was politically motivated as the government faced its first major challenge at the general elections in June 2000. It remains unclear whether this will lead to long term reductions in tobacco production, although future global declines in demand could weaken the tobacco lobby. However, since Zimbabwe is only a minor consumer of tobacco, a unique opportunity does exist to develop controls on domestic cigarette consumption. To achieve this the isolated ministry of health would need considerable support from international agencies, such as the World Health Organisation and World Bank.

  8. Ethno-Confessional Realities in the Romanian Area: Historical Perspectives (XVIII-XX centuries)

    OpenAIRE

    Brie, Mircea; Şipoş, Sorin; Horga, Ioan

    2011-01-01

    Ethno-Confessional Realities in the Romanian Area: Historical Perspectives (XVII-XX Centuries) This present collective volume, coordinated by Mircea Brie, Sorin Şipoş and Ioan Horga, contains the papers of the international conference Ethnicity, Confession and Intercultural Dialogue at the European Union’s East Border (workshop: Ethno-Confessional Realities in the Romanian Area: Historical Perspectives), held in Oradea between 2nd-5th of June 2011. This international conference, organized...

  9. Healthy ageing - from molecules to hormesis

    DEFF Research Database (Denmark)

    Rattan, Suresh

    2012-01-01

    Ageing can be understood at various levels, from evolutionary and biological levels to psychological and sociological levels. At the molecular biological level ageing is characterized by the stochastic occurrence and progressive accumulation of molecular damage. Failure of homeodynamics, increased...... molecular heterogeneity, altered cellular functioning and reduced stress tolerance are the determinants of health status, probability of diseases and the duration of survival. The inefficiency and imperfection of the maintenance and repair systems underlie the biological basis of ageing. Two major issues...... life style alterations are examples of ageing interventions. A promising healthy-ageing approach is that of hormesis by strengthening the homeodynamic ability of self-maintenance through transient and repetitive mild stress-inducing hormetins. Achieving the goal of extended health-span will depend...

  10. Comparative Examination of Fair Value Accounting and Historical Cost Accountingin Perspective of Advantages and Disadvantages

    OpenAIRE

    Arı, Mustafa; Yılmaz, Rıfat

    2015-01-01

    In this study, it has examined that advantages and disadvantages of fair value accounting and historical cost accounting in comparatively. We discuss advantages and disadvantages of produced financial information according to fair value accounting and historical cost accounting in perspective of reliability, relavance, transparency, intelligibility, comparability, timeliness and financial stability. Literature review results of this study indicate that there are advantages and disadvantages b...

  11. The Self Attenuation Correction for Holdup Measurements, a Historical Perspective

    International Nuclear Information System (INIS)

    Oberer, R. B.; Gunn, C. A.; Chiang, L. G.

    2006-01-01

    Self attenuation has historically caused both conceptual as well as measurement problems. The purpose of this paper is to eliminate some of the historical confusion by reviewing the mathematical basis and by comparing several methods of correcting for self attenuation focusing on transmission as a central concept

  12. Greenhouse effect and ice ages: historical perspective; Effet de serre et glaciations, une perspective historique

    Energy Technology Data Exchange (ETDEWEB)

    Bard, E. [College de France, Chaire d' Evolution du Climat et de l' Ocean, 75 - Paris (France); CEREGE (UMR 6635), 13 - Aix en Provence (France)

    2004-06-01

    This article provides a brief historical perspective on the first scientific research on the greenhouse effect and glaciations. While these two aspects of our climate can be investigated separately, naturalists, physicists and chemists during the 19. century were interested jointly in both issues, as well as the possible relationship between them. The contributions of famous pioneers are mentioned, ranging from scholars with encyclopedic knowledge such as Horace-Benedict de Saussure, to modern scientists like Svante Arrhenius, who was first to predict global warming as a consequence of using fossil fuels. Despite fragmentary observations, these pioneers had prophetic insights. Indeed, the main fundamental concepts used nowadays have been developed during the 19. century. However, we must wait until the second half of the 20. century to see a true revolution of investigative techniques in the Earth Sciences, enabling full access to previously unknown components of the climate system, such as deep oceans and the interior of the polar ice caps. (author)

  13. Radiation hormesis, public health, and public policy: a commentary

    Energy Technology Data Exchange (ETDEWEB)

    Hickey, R J; Bowers, E J; Clelland, R C

    1983-03-01

    Public policy affecting public health regarding effects of low-level ionizing radiations has been, and is being, determined by effects estimates based on linear or other monotonic extrapolation from high-level radiation dose-response data to presumed ecologically realistic low-level exposure effects. Such predictive, unmeasured estimates are very possibly in serious error; they are incompatible with observed low-level dose-response data that indicate a negative correlation between low-level radiation data and health effects, such as cancer mortality rates. Observed negative correlations with low-level radiation data are to be expected on the basis of evidence supporting the validity of the hormesis phenomenon. Hormesis theory, derived in part from evolutionary biology, asserts that while high levels of exposure to an agent such as ionizing radiation are indeed hazardous, ecologically realistic low levels can be stimulatory and largely beneficial. Stimulation of activities of DNA and other repair mechanisms may be involved. Although evidence of the reality of radiation hormesis has been reported in about 1000 scientific publications over the last century, this effect has been largely unrecognized. Moreover, this widespread non-acceptance of hormesis as a real-world phenomenon is usually but not always present in the case of chemical hormesis; the oversight appears systematic. The ignoring of the hormesis phenomenon seems to constitute a very serious error in modern biomedical science and in preventive medicine. A mathematical model is offered that describes the general shape of certain dose-response functions when radiation hormesis at low-level exposure is taken into consideration along with the well-known detrimental effects of high-level radiation.

  14. Historical Perspectives on Games and Education from the Learning Sciences

    Science.gov (United States)

    Shelton, Brett E.; Satwicz, Tom; Caswell, Tom

    2011-01-01

    This paper reviews three classic theorists' writing on games, learning, and development. Piaget, Vygotsky, and Bruner all wrote about games and play as important to thinking and learning. This review attempts to synthesize their perspectives as a means to revisit underused theoretical perspectives on the role of games in education. The views of…

  15. Contextualizing Corporate Political Responsibilities: Neoliberal CSR in Historical Perspective

    OpenAIRE

    Djelic, Marie-Laure; Etchanchu, Helen

    2015-01-01

    This article provides a historical analysis of the political role of Corporate Social Responsibility (CSR) before it was even called CSR. We describe two ideal types of political responsibilities during the eras of 19th century paternalism in Europe and corporate trusteeship in the US. Our historical contextualization of recent scholarly work on a “political turn” of CSR offers a two-pronged critique: 1. Growing discussions on political CSR start from a problematic foundation that does not ho...

  16. Radiation hormesis and its potential to manage radiation injuries

    International Nuclear Information System (INIS)

    Bala, Madhu; Mathew, Lazar

    2000-01-01

    The term radiation hormesis explains stimulatory or beneficial effects of low dose radiation exposure, which cannot be predicted by extrapolation of detrimental or lethal effects of high dose radiation exposure. Although beneficial effects of low doses of radiation were observed soon after discovery of x-rays and radioactivity, studies remained inconclusive until recently, due to (i) inadequate statistical planning of experiments conducted in early part of the 20th century; and (ii) poor dose monitoring. Recently (1980s onwards), large scale, systematic epidemiological and experimental studies with a number of diverse systems have demonstrated existence of radiation hormesis beyond doubt. It is pointed out that the hormetic effects of radiation have not been successfully exploited so far for human benefits, primarily because underlying molecular mechanisms are poorly understood. It is argued that with more and more studies, it is becoming evident that radiation hormesis is not merely physiological adaptation, but a genetically regulated phenomenon and involves de novo synthesis of proteins. Role of these proteins in induction of radiation hormesis is the current area of research in a number of world-renowned laboratories. The first part of this review elucidates the shifts in paradigms on radiation effects in the 20th century and the later portion presents a brief on underlying molecular mechanisms of radiation hormesis and their implications towards management of radiation injuries. (author)

  17. Hormesis: Decoding Two Sides of the Same Coin

    Directory of Open Access Journals (Sweden)

    Dipita Bhakta-Guha

    2015-12-01

    Full Text Available In the paradigm of drug administration, determining the correct dosage of a therapeutic is often a challenge. Several drugs have been noted to demonstrate contradictory effects per se at high and low doses. This duality in function of a drug at different concentrations is known as hormesis. Therefore, it becomes necessary to study these biphasic functions in order to understand the mechanistic basis of their effects. In this article, we focus on different molecules and pathways associated with diseases that possess a duality in their function and thus prove to be the seat of hormesis. In particular, we have highlighted the pathways and factors involved in the progression of cancer and how the biphasic behavior of the molecules involved can alter the manifestations of cancer. Because of the pragmatic role that it exhibits, the imminent need is to draw attention to the concept of hormesis. Herein, we also discuss different stressors that trigger hormesis and how stress-mediated responses increase the overall adaptive response of an individual to stress stimulus. We talk about common pathways through which cancer progresses (such as nuclear factor erythroid 2-related factor 2-Kelch-like ECH-associated protein 1 (Nrf2-Keap1, sirtuin-forkhead box O (SIRT-FOXO and others, analyzing how diverse molecules associated with these pathways conform to hormesis.

  18. Insecticide-induced hormesis and arthropod pest management.

    Science.gov (United States)

    Guedes, Raul Narciso C; Cutler, G Christopher

    2014-05-01

    Ecological backlashes such as insecticide resistance, resurgence and secondary pest outbreaks are frequent problems associated with insecticide use against arthropod pest species. The last two have been particularly important in sparking interest in the phenomenon of insecticide-induced hormesis within entomology and acarology. Hormesis describes a biphasic dose-response relationship that is characterized by a reversal of response between low and high doses of a stressor (e.g. insecticides). Although the concept of insecticide-induced hormesis often does not receive sufficient attention, or has been subject to semantic confusion, it has been reported in many arthropod pest species and natural enemies, and has been linked to pest outbreaks and potential problems with insecticide resistance. The study of hormesis remains largely neglected in entomology and acarology. Here, we examined the concept of insecticide-induced hormesis in arthropods, its functional basis and potential fitness consequences, and its importance in arthropod pest management and other areas. © 2013 Society of Chemical Industry.

  19. Hormesis in Regulatory risk assessment - Science and Science Policy.

    Science.gov (United States)

    Gray, George

    2011-01-01

    This brief commentary will argue that whether hormesis is considered in regulatory risk assessment is a matter less of science than of science policy. I will first discuss the distinction between science and science policy and their roles in regulatory risk assessment. Then I will focus on factors that influence science policy, especially as it relates to the conduct of risk assessments to inform regulatory decisions, with a focus on the U.S. Environmental Protection Agency (EPA). The key questions will then be how does hormesis interact with current concepts of science and science policy for risk assessment? Finally, I look ahead to factors that may increase, or decrease, the likelihood of hormesis being incorporated into regulatory risk assessment.

  20. Historical perspective on diameter-limit cutting in northeastern forests

    Science.gov (United States)

    Matthew J. Kelty; Anthony W. D' Amato; Anthony W. D' Amato

    2006-01-01

    The use of diameter-limit cutting and high-grading is currently a concern for long-term sustainability of forests in the Northeastern United States and surrounding areas. This paper reviews historical information about the kinds of harvesting used in this region from 1620 to 1950, to provide a context for current discussions. Throughout this period, most timber...

  1. The Aesthetic As Immediately Sensuous: An Historical Perspective

    Science.gov (United States)

    Madenfort, Duke

    1974-01-01

    The views of Immanuel Kant, Soren Kierkegaard, Henri Bergson, John Dewey, and Susanne Langer were discussed. In this article they served as five important figures in a historical account of the concept of the aesthetic as the immediately sensuous. (Author/RK)

  2. The Obligations of American Citizenship: A Historical Perspective.

    Science.gov (United States)

    Murphy, Paul L.

    1983-01-01

    Historical antecedents of modern constitutionalism are examined, and the concepts of citizen participation, civic responsibility, and limitation of government are explained in that context. Students must be exposed to the constitutional basics--why the document is retained, what values it incorporates, and where it has succeeded and failed. (PP)

  3. Accumulation and management in global historical perspective: An introduction

    NARCIS (Netherlands)

    Roberts, Lissa L.

    2014-01-01

    This essay introduces a special issue dedicated to the theme ‘accumulation and management in global historical perspective’. The concepts and practices of accumulation and management are explored in ways that work to de-center the history of science and empire. Particular attention is paid to four

  4. Historic perspective: Prebiotics, probiotics, and other alternatives to antibiotics

    Science.gov (United States)

    Antibiotic applications in agricultural and human medical arenas have resulted in tremendous increases in food animal production and historically unprecedented gains in human health protection. Successes attributed to wide-spread antibiotic use have been accompanied by the inadvertent emergence of r...

  5. Pirates, ports, and coasts in Asia: historical and contemporary perspectives

    NARCIS (Netherlands)

    Kleinen, J.; Osseweijer, M.

    2010-01-01

    Pirates, Ports and Coasts in Asia aims to fill in some of the historical gaps in the coverage of maritime piracy and armed robbery in Asia. The authors highlight a variety of activities ranging from raiding, destroying and pillaging coastal villages and capturing inhabitants to attacking and taking

  6. The Toolbox of Proton Spin Physics in Historical Perspective

    International Nuclear Information System (INIS)

    Haeberli, Willy

    2008-01-01

    This paper was part of the general-interest session on lecture day, and is thus addressed to a general audience. A 50-year historic overview of the development of the tools of proton spin physics is presented: nuclear scattering, ion sources for polarized protons and deuterons based on atomic beam and optical pumping methods, and polarized gas targets

  7. Art as an investment in a historical perspective

    NARCIS (Netherlands)

    David, Geraldine

    2016-01-01

    This dissertation studies the price formation mechanisms on the art market. More specifically, it uses historical data to test the impact of several factors on the French art market between 1860 and 1950 and on the Belgian art market between 1945 and 1950. The first paper investigates the link

  8. The Materiality of Digital Collections: Theoretical and Historical Perspectives

    Science.gov (United States)

    Manoff, Marlene

    2006-01-01

    Digital and textual objects are coming under a new kind of scrutiny as scholars are becoming more interested in physical artifacts and their relation to their social and cultural environment. This study of material culture suggests a need to explore the nature of digital materiality, as well as the broader historical context in which electronic…

  9. The Statue of Liberty: Double Stories Provide Historical Perspective

    Science.gov (United States)

    Britt, Judy

    2013-01-01

    Standing tall in New York Harbor, the Statue of Liberty is an enduring symbol of America. Layers of historical content and symbolism are uncovered in books that tell various parts of her story. By reading one or more of these books, students can begin to see that the experience of immigration is complex--it's not one narrative, but many that…

  10. Children's Generalization of Strategies: An Historical Perspective on Transfer.

    Science.gov (United States)

    Cox, Brian D.; And Others

    As an aid to contemporary research, this paper examines historical ideas about young children's use of strategies for memorization and the transfer of such strategies to different contexts. Discussion focuses on (1) current approaches to inducing transfer of strategies; (2) Thorndike and Woodworth's concept of identical elements; (3) Gestalt…

  11. Molecular stress response pathways as the basis of hormesis

    DEFF Research Database (Denmark)

    Demirovic, Dino; de Toda, Irene Martinez; Rattan, Suresh

    2014-01-01

    There is now a large amount of data available for human beings showing positive hormetic effects of mild stresses from physical, chemical, nutritional and mental sources. However, these data are dispersed in the literature and not always interpreted as hormetic effects, thus restricting their full...... apprehension and application. A comprehensive discussion of the research, this book is composed of four sections: (1) History and terminology; (2) Evidence for hormesis in humans; (3) Molecular mechanisms of hormesis; and (4) Ethical and legal aspects, and risk assessment....

  12. Radiation hormesis and the linear-no-threshold assumption

    CERN Document Server

    Sanders, Charles L

    2009-01-01

    Current radiation protection standards are based upon the application of the linear no-threshold (LNT) assumption, which considers that even very low doses of ionizing radiation can cause cancer. The radiation hormesis hypothesis, by contrast, proposes that low-dose ionizing radiation is beneficial. In this book, the author examines all facets of radiation hormesis in detail, including the history of the concept and mechanisms, and presents comprehensive, up-to-date reviews for major cancer types. It is explained how low-dose radiation can in fact decrease all-cause and all-cancer mortality an

  13. Perspectives : anecdotal, historical and critical commentaries on genetics

    Science.gov (United States)

    Bryan K. Epperson

    1999-01-01

    The purpose of this article is to give a personal perspective of the person of Gustave Malecot and a conceptual account of his contributions to the field of population genetics. Some essential biographical information is given, but more important are some insights he himself gave into his early career. I was privileged to have him share these insights with me over the...

  14. The double-contingency principle: An historical perspective

    International Nuclear Information System (INIS)

    Knief, R.A.

    1995-01-01

    Standard ANSI/ANS-8.1 states the double contingency principle as: Process designs should, in general, incorporate sufficient factors of safety to require at least two unlikely, independent, and concurrent changes in process conditions before a criticality accident is possible. This paper presents a perspective on the double contingency principle

  15. "Fuzziness" in the celular interactome: a historical perspective.

    Science.gov (United States)

    Welch, G Rickey

    2012-01-01

    Some historical background is given for appreciating the impact of the empirical construct known as the cellular protein-protein interactome, which is a seemingly de novo entity that has arisen of late within the context of postgenomic systems biology. The approach here builds on a generalized principle of "fuzziness" in protein behavior, proposed by Tompa and Fuxreiter.(1) Recent controversies in the analysis and interpretation of the interactome studies are rationalized historically under the auspices of this concept. There is an extensive literature on protein-protein interactions, dating to the mid-1900s, which may help clarify the "fuzziness" in the interactome picture and, also, provide a basis for understanding the physiological importance of protein-protein interactions in vivo.

  16. Family types and intimate-partner violence: A historical perspective

    OpenAIRE

    Ana Tur-Prats

    2015-01-01

    This paper examines the historical origins of violence against women, in contrast to earlier literature, which focused only on short-term determinants. It analyses the relationship between traditional family patterns (stem versus nuclear) and intimate-partner violence (IPV). Stem families are those in which one child stays in the parental household with spouse and children, so that at least two generations live together. I model the behavior of a traditional peasant family and show how coresi...

  17. Latin American Civil-Military Relationships in a Historical Perspective

    OpenAIRE

    Skaar, Elin

    2013-01-01

    Civil-military relationships constitute a crucial element in the transition to substantive democracy all over the world. During periods of authoritarianism or civil war, the military in Latin America has historically speaking been responsible for extensive violations of human rights and humanitarian law. Since the reintroduction of democracy in the region in the 1980s and 1990s, the military has gradually been brought back under civilian rule. The balance of power between military and civil p...

  18. Historical Perspective on Familial Gastric CancerSummary

    OpenAIRE

    C. Richard Boland; Matthew B. Yurgelun

    2017-01-01

    Gastric cancer is a common disease worldwide, typically associated with acquired chronic inflammation in the stomach, related in most instances to infection by Helicobacter pylori. A small percentage of cases occurs in familial clusters, and some of these can be linked to specific germline mutations. This article reviews the historical background to the current understanding of familial gastric cancer, focuses on the entity of hereditary diffuse gastric cancer, and also reviews the risks for ...

  19. Historical Perspectives and Recent Trends in the Coastal Mozambican Fishery

    Directory of Open Access Journals (Sweden)

    Jessica L. Blythe

    2013-12-01

    Full Text Available Historical data describing changing social-ecological interactions in marine systems can help guide small-scale fisheries management efforts. Fisheries landings data are often the primary source for historical reconstructions of fisheries; however, we argue that reliance on data of a single type and/or from a single scale can lead to potentially misleading conclusions. For example, a narrow focus on aggregate landings statistics can mask processes and trends occurring at local scales, as well as the complex social changes that result from and precipitate marine ecosystem change. Moreover, in the case of many small-scale fisheries, landings statistics are often incomplete and/or inaccurate. We draw on case study research in Mozambique that combines national landings statistics and career history interviews with fish harvesters to generate a multi-scale historical reconstruction that describes social-ecological interactions within the coastal Mozambican fishery. At the national level, our analysis points toward trends of fishing intensification and decline in targeted species, and it highlights the significant impact of small-scale fisheries on marine stocks. At the local level, fishers are experiencing changes in fish abundance and distribution, as well as in their physical, social, and cultural environments, and have responded by increasing their fishing effort. We conclude with a discussion of the governance implications of our methodological approach and findings.

  20. A Historical Perspective of the Atlantic’s Evolution

    OpenAIRE

    Teixeira, Nuno Severiano; Marcos, Daniel

    2016-01-01

    SFRH/BPD/75764/2011 UID/CPO/04627/2013 565280-EPP-1-2015-1-USEPPJMO-NETWORK In the last two centuries, several key moments have defined the Atlantic Basin’s history that help us understand its present. This chapter endeavours to present a comprehensive overview of this evolution, pointing out key events that set up the historical links that still play a role in the Atlantic. In the first section, following a chronological approach, it shows how the American and the French Revolutions...

  1. Historical and epistemological perspectives on research and nursing.

    Science.gov (United States)

    Cushing, A

    1994-09-01

    This paper examines four main themes with respect to some problematic issues concerning the discipline of nursing, nursing scholarship and the social sciences. First, attention is directed to the controversial issues concerning nursing's search for a knowledge base. Second, a historical context is provided by drawing attention to some key developments between the quantitative and qualitative approaches to research in nursing. Third, the issue of the fundamental and attested difficulties in the application of qualitative methodologies is addressed. Finally, it is submitted that in the interest of nursing's future as a scholarly endeavour, the discipline should focus polemic attention on the body of knowledge already accumulated.

  2. Innovation in science and organizational renewal historical and sociological perspectives

    CERN Document Server

    Münch, Richard

    2016-01-01

    This book looks at the types of new research organizations that drive scientific innovation and how ground-breaking science transforms research fields and their organization. Based on historical case studies and comparative empirical data, the book presents new and thought-provoking evidence that improves our knowledge and understanding about how new research fields are formed and how research organizations adapt to breakthroughs in science. While the book is firmly based in science history, it discusses more general sociological and policy propositions regarding scientific innovations and organizational change. The volume brings together leading scholars both from the United States and Europe.

  3. Public and Private Intelligence: Historical and Contemporary Perspectives

    Directory of Open Access Journals (Sweden)

    Ruth Delaforce

    2013-06-01

    Full Text Available Intelligence is often regarded as information that is special or different, which must be safely kept. When sought, collected or used by the private sector, as opposed to public agencies, concerns are raised on the purpose and propriety of such an activity. However, in an historical context, intelligence collection or sharing between public and private interests for the purpose of national security was not unusual, particularly during the Cold War. Case studies from this era indicate that overlapping concerns were economic success combined with political strategy. Glimpses of these shared interests between the state and business can also be identified in the immediate post-Cold War era, and the aftermath of terrorist attacks in 2001. Perhaps the greatest contemporary change is not that “private” and “public” intelligence is shared between business and state, but the extent of such an enterprise. Further issues related to this change are: state dominance in the public-private relationship; potential fragmentation in the intelligence process; gaps in the historical record; and implications for future generations of intelligence professionals.

  4. Bitcoin and Potosí Silver: Historical Perspectives on Cryptocurrency.

    Science.gov (United States)

    Zimmer, Zac

    Bitcoin, the digital cryptocurrency, has been celebrated as the future of money on the Internet. Although Bitcoin does present several forward-looking innovations, it also integrates a very old concept into its digital architecture: the mining of precious metals. Even though Bitcoin explicitly invokes mining as a metaphor and gold as an example for understanding the cryptocurrency, there has been little critical work on the connections between Bitcoin and previous metalist currency regimes. The following essay proposes a historical comparison with colonial South American silver mining and the global currency regime based on the New World silver peso it created as a way to interrogate Bitcoin. The comparison with colonial South America, and specifically the silver mining economy around the Cerro Rico de Potosí, will help to develop a historical and political understanding of Bitcoin's stakes, including questions of resources, labor, energy, and ecology. Mining and the extractive apparatus that accompanies it always imply massive-scale earthworks that reshape the planet itself, a process known as terraforming. The Potosí comparison will reveal Bitcoin to form part of a similar process of digital primitive accumulation we can provisionally name cryptoforming.

  5. A historical perspective on the collaboration between psychoanalysis and neuroscience.

    Science.gov (United States)

    Sauvagnat, François; Wiss, Matthias; Clément, Sandra

    2010-12-01

    The aim of this article is to present and discuss the connections between psychoanalysis and neuroscience from a historical viewpoint. We start by examining how Sigmund Freud can be viewed as a pioneer in the interaction between these two fields. Freud was himself a neurologist and had maintained an interest in biology as he developed the key concepts of psychoanalysis. His ideas regarding psychosomatics are described. We will also explore how the concept of drive is essential to the connection between psychoanalysis and neuroscience. Then, we describe several key actors and historical events and characters at the interface of these two fields, namely Sándor Radó Lawrence S. Kubie and Mc Culloch, the debates that took place during the Macy conferences, as well as the positions of Jacques Lacan, George L. Engel, and Eric Kandel. Finally, we present a synthesis of the main fields in which the connections between psychoanalysis and neuroscience are already fruitful, and those where they should be developed: the classification of mental diseases, the link between the scientific and psychic dimensions, therapeutics, the organization of the body, intersubjectivity, the subjective division and ambivalence, as well as transferential effects like such as the placebo and nocebo effects. In the conclusion, we advocate several strategic alliances and underscore the complementarity between rigorous scientific experimentation and the individualized psychoanalytic approach. Copyright © 2010 Elsevier Ltd. All rights reserved.

  6. Diagnostic Perspectives on the Family: Process, Structural and Historical Contextual Models.

    Science.gov (United States)

    Levant, Ronald F.

    1983-01-01

    Describes diagnostic perspectives for viewing dysfunctional families. Presents three general types of models (process, structural, and historical) and organized them along a continuum from most descriptive to most inferential. Presented at the 39th Annual Conference of the American Association for Marriage and Family Therapy, October-November…

  7. A Historical Perspective on Gender Inequality and Development in the World Economy, c. 1850-2000

    NARCIS (Netherlands)

    Dilli, S.D.|info:eu-repo/dai/nl/370724267

    2015-01-01

    The main objective of this dissertation is to add a historical perspective to the debate on the link between gender inequality and development. To do so, the dissertation first documents global gender differences in life expectancy and sex ratios (to cover health status); in average years of

  8. A Historical Perspective on Student Affairs Professionals' Use of Digital Technology

    Science.gov (United States)

    Cabellon, Edmund T.; Payne-Kirchmeier, Julie

    2016-01-01

    This chapter provides a historical perspective of student affairs professionals' use of digital and social technologies in their work on college campuses. The purpose of the chapter is to describe how digital technology tools have evolved since 2005, demonstrate how student affairs technology shifted and changed during this time, and shape student…

  9. Computer Science Education in French Secondary Schools: Historical and Didactical Perspectives

    Science.gov (United States)

    Baron, Georges-Louis; Drot-Delange, Beatrice; Grandbastien, Monique; Tort, Françoise

    2014-01-01

    Computer science as a school subject in France is characterized by a succession of promising starts that have not yet been transformed into perennial solutions. The main goal of this article is to analyze this complex situation from a historical perspective, and describe the current rebirth of an optional Computer Science course in the last year…

  10. Historical and Cultural Perspectives on Centralization/Decentralization in Continuing Education.

    Science.gov (United States)

    Edelson, Paul J.

    1995-01-01

    Views centralization/decentralization from four perspectives: historical, as an outgrowth of professionalism, in the culture of higher education, and management theory. Suggests that some form of centralized control will always be necessary if continuing education is to function in a larger organization, but smaller units may be the wave of the…

  11. Hormesis and homeopathy: The and nbsp;artificial twins

    Directory of Open Access Journals (Sweden)

    Sergei V Jargin

    2015-03-01

    Full Text Available Homeopathy claims a curative reaction from small doses of a substance, high doses of which cause symptoms similar to those the patient is suffering from. Hormesis is a concept of biphasic dose-response to different pharmacological and toxicological agents. According to this concept, a small dose of a noxious agent can exert a beneficial action. A hypothesis is defended here that hormesis as a general principle can be assumed only for the factors present in the natural environment thus having induced adaptation of living organisms. Generalizations of the hormesis phenomenon used in support of homeopathy are unfounded. Low-dose impacts may be associated with a higher risk in a state of organ sub-compensation or failure especially in the elderly patients. Practical recommendations should be based neither on the hormesis as a default approach nor on the postulates of homeopathy. All clinically relevant effects, hormetic or not, should be tested by the methods of evidence-based medicine. [J Intercult Ethnopharmacol 2015; 4(1.000: 74-77

  12. Advance of study on hormesis of low dose radiation

    International Nuclear Information System (INIS)

    Su Liaoyuan

    2003-01-01

    There have been growing interests in recent years over the effects of low doses of ionizing radiation on human. The paper gives a brief review on the LDR studies, which include LDR-induced hormesis and adaptive response, LDR experiments in vivo or in vitro and epidemiologic investigation, and clinical applications of LDR as well

  13. The occurrence of hormesis in plants and algae

    DEFF Research Database (Denmark)

    Cedergreen, Nina; Streibig, Jens Carl; Kudsk, Per

    2007-01-01

    This paper evaluated the frequency, magnitude and dose/concentration range of hormesis in four species: The aquatic plant Lemna minor, the micro-alga Pseudokirchneriella subcapitata and the two terrestrial plants Tripleurospermum inodorum and Stellaria media exposed to nine herbicides and one...

  14. Radio listening in a life-historical perspective

    DEFF Research Database (Denmark)

    Blaakilde, Anne Leonora

    are interpreted as material-semiotic interactions, as well as the embodied and subjective experiences and memories in time and space are interpreted in a postphenomenological perspective. Encompassing these rather different theories is the notion of soundscape (Schafer) which, in a newer reading inspired by John...... things matter. UCL Press, London. Pink, Sarah and Mackley, Kerstin Leder 2013. Saturated and situated: expanding the meaning of media in the routines of everyday life. Media Culture Society, vol. 35, no. 6: 677-691. Schafer, R. Murray 1994. The Soundscape: Our Sonic Environment and the Tuning...

  15. Historical perspective on the moon base: the British experience

    International Nuclear Information System (INIS)

    Jones, E.M.; Finney, B.R.

    1984-01-01

    Among the many historical episodes that have relevance to the establishment of a human base, the voyages of Captain Cook, and the founding of Britain's Botany Bay colony in Australia seems particularly appropriate. The process resulting in the selection of Cook rewards study, as do his relations with the Admiralty, with the scientific establishment and with the scientists who accompanies him. Britain's tight control of the Botany Bay settlement and its unwillingness to promote early self-sufficiency may have delayed the time when Australia became self-supporting. Structuring the lunar base to offer opportunities for private initiatives may hasten the day when it becomes a self-supporting settlement rather than an externally supported scientific base on an Antarctic model

  16. Chronic Subdural Hematoma: A Historical and Clinical Perspective.

    Science.gov (United States)

    Sahyouni, Ronald; Goshtasbi, Khodayar; Mahmoodi, Amin; Tran, Diem K; Chen, Jefferson W

    2017-12-01

    This review aims to highlight the clinical complexity of chronic subdural hematoma (cSDH) while presenting a brief historical discussion of cSDH. A thorough literature search of published English-language papers was performed in PubMed, Ovid, and Cochrane databases. cSDH affects 1-5.3 per 100,000 individuals annually, with the incidence expected to rise as the U.S. population ages. The symptoms of cSDH are often nonspecific, with headaches being the most common complaint. Other symptoms include weakness, balance and gait problems, and memory problems. A variety of clinical factors must be taken into account in the treatment of cSDH, and the multifaceted treatment paradigms continue to evolve. Copyright © 2017. Published by Elsevier Inc.

  17. The relativity revolution from the perspective of historical epistemology.

    Science.gov (United States)

    Renn, Jürgen

    2004-12-01

    This essay analyzes Einstein's relativity revolution as part of a long-term development of knowledge in which the knowledge system of classical physics was reorganized in a process of reflection, described here as a "Copernican process." This process led in 1905 to the introduction of fundamentally new concepts of space, time, matter, and radiation. On the basis of an extensive historical reconstruction, the heuristics of Einstein's creation of the general theory of relativity, completing the relativity revolution, is interpreted as a further transformation of the knowledge of classical physics, starting from conceiving gravitation as a borderline problem between field theory and mechanics. The essay thus provides an answer to the puzzle of how Einstein was able to create a theory capable of accounting for a wide range of phenomena that were discovered only much later.

  18. Professionalethics, deontology and unionism in brazilian librarianship: multiple historical perspectives

    Directory of Open Access Journals (Sweden)

    Jessé Albino Santana

    2017-09-01

    collection, bibliographical and documental research. It presents concepts related to ethics as a science and its importance in the field of professions. It relates ethics and deontology, understanding this as a science of duty, responsible for ascertaining how the norms guiding the professional classes arise and are sustained. It evokes historical elements of the trade union movement in England, its arrival in Brazil and the beginning of unionization of Brazilian librarians. As a result, it highlights the need to broaden the debates about professional ethics and the maturation of class consciousness in Librarianship, which may have repercussions on collective actions of greater visibility with society.

  19. Historical perspective of the H- Ion Source Symposia

    International Nuclear Information System (INIS)

    Schmidt, C.W.

    1997-11-01

    The International Symposium on the Production and Neutralization of Negative Hydrogen Ions and Beams is entering its third decade of providing a forum for the H - ion source community. The first meeting was held at Brookhaven National Laboratory in 1977 and has returned there every three years to 1995. This is the eighth meeting in this series and for the first time is in Europe, hosted by CEA/Center de Cadarache. Since this Symposium is meeting in Europe many new people have had an opportunity to attend and many of these are of a younger generation. On the 20th anniversary of the First Symposium it seems fitting that a historical review should be given. The Symposium meetings and its archiving of information has been a valuable asset to this community. I hope to briefly describe the early H - source work and provide some insight into the success of the H - source effort

  20. European Welfare State in a Historical Perspective. A Critical Review

    Directory of Open Access Journals (Sweden)

    George Marian ŞTEFAN

    2015-06-01

    Full Text Available This paper provides an analysis of the historical evolution of the European welfare state, especially after the second half of the nineteenth century. Even if one considers that social protection systems have their origins in the period of German Chancellor Otto von Bismarck, various social problems have been treated in European countries before the Bismarck’s social legislation, beginning with the sixteenth century. In this article we presented mainly (i the origins of social policy systems in Europe, as shown in the literature covered, (ii the conceptual evolution of the so-called “welfare state” and (iii the development of social security schemes based on International Labour Organization typology.

  1. Historical perspective of the H- ion source symposia

    International Nuclear Information System (INIS)

    Schmidt, C.W.

    1998-01-01

    The International Symposium on the Production and Neutralization of Negative Hydrogen Ions and Beams is entering its third decade of providing a forum for the H - ion source community. The first meeting was held at Brookhaven National Laboratory in 1977 and has returned there every three years to 1995. This is the eighth meeting in this series and for the first time is in Europe, hosted by CEA/Center de Cadarache. Since this Symposium is meeting in Europe many new people have had an opportunity to attend and many of these are of a younger generation. On the 20th anniversary of the First Symposium it seems fitting that a historical review should be given. The Symposium meetings and its archiving of information has been a valuable asset to this community. I hope to briefly describe the early H - source work and provide some insight into the success of the H - source effort. copyright 1998 American Institute of Physics

  2. Historical perspective of the H- ion source symposia

    International Nuclear Information System (INIS)

    Schmidt, C. W.

    1998-01-01

    The International Symposium on the Production and Neutralization of Negative Hydrogen Ions and Beams is entering its third decade of providing a forum for the H - ion source community. The first meeting was held at Brookhaven National Laboratory in 1977 and has returned there every three years to 1995. This is the eighth meeting in this series and for the first time is in Europe, hosted by CEA/Center de Cadarache. Since this Symposium is meeting in Europe many new people have had an opportunity to attend and many of these are of a younger generation. On the 20th anniversary of the First Symposium it seems fitting that a historical review should be given. The Symposium meetings and its archiving of information has been a valuable asset to this community. I hope to briefly describe the early H - source work and provide some insight into the success of the H - source effort

  3. Historical Perspectives and Guidelines for Botulinum Neurotoxin Subtype Nomenclature

    Directory of Open Access Journals (Sweden)

    Michael W. Peck

    2017-01-01

    Full Text Available Botulinum neurotoxins are diverse proteins. They are currently represented by at least seven serotypes and more than 40 subtypes. New clostridial strains that produce novel neurotoxin variants are being identified with increasing frequency, which presents challenges when organizing the nomenclature surrounding these neurotoxins. Worldwide, researchers are faced with the possibility that toxins having identical sequences may be given different designations or novel toxins having unique sequences may be given the same designations on publication. In order to minimize these problems, an ad hoc committee consisting of over 20 researchers in the field of botulinum neurotoxin research was convened to discuss the clarification of the issues involved in botulinum neurotoxin nomenclature. This publication presents a historical overview of the issues and provides guidelines for botulinum neurotoxin subtype nomenclature in the future.

  4. A historical perspective of synthetic ceramic and traditional feldspathic porcelain.

    Science.gov (United States)

    Chu, Stephen; Ahmad, Irfan

    2005-10-01

    Ceramics were invented by the Chinese during the T'ang Dynasty, where they quickly became a precious commodity. By the early 18th Century, ceramics found its way into dentistry due to its high strength, biocompatibility, and malleability. Today, ceramic materials are a staple in dentistry, available in both naturally based and partially synthetic formulas. Most recently they have become available as quartz-glass synthetic materials manufactured under controlled conditions to eliminate the inconsistencies and impurities inherent in the naturally based counterpart. This article details the discovery of porcelain and its role as a precious substance throughout the world and time, from its initial use as ornamental earthenware to its practical application in modern dentistry. Upon reading this article, the reader should: Understand the historical significance of porcelain. Recognize the fundamental constituents and physical properties of both natural feldspathic porcelains and fully synthetic ceramics used in dentistry.

  5. Systems Approaches: A Global and Historical Perspective on Integrative Medicine

    Science.gov (United States)

    2012-01-01

    The globalization of healing systems is a dance of cultural awareness and cultural dominance that has arisen throughout history. With the development of greater communication and interest in whole-systems approaches to healing, the opportunity for the development of a global perspective on healing has emerged with new life force. The birth of integrative holistic healing systems in the West, such as naturopathic, homeopathic, anthroposophic, integral and functional medicine, and others, echoes the ocean of wisdom present in traditional healing systems, such as traditional Chinese medicine (TCM) and Ayurveda. In working to integrate the lessons from these systems, we see the inextricable link between man and the natural world, we work to understand the root cause of disease, we focus on the whole person to return balance, and we use empiric observation in large populations over time to grasp the interrelationships inherent in the whole-systems view of illness and wellness. PMID:24278794

  6. Directly smelted lead-tin alloys: A historical perspective

    Science.gov (United States)

    Dube, R. K.

    2010-08-01

    This paper discusses evidence related to the genesis and occurrence of mixed lead-tin ore deposit consisting of cassiterite and the secondary minerals formed from galena. These evidences belong to a very long time period ranging from pre-historic to as late as the nineteenth century a.d. This type of mixed ore deposits was smelted to prepare lead-tin alloys. The composition of the alloy depended on the composition of the starting ore mixture. A nineteenth century evidence for the production of directly smelted lead-tin alloys in southern Thailand is discussed. A unique and rather uncommon metallurgical terminology in Sanskrit language— Nāgaja—was introduced in India for the tin recovered from impure lead. This suggests that Indians developed a process for recovering tin from lead-tin alloys, which in all probability was based on the general principle of fire refining. It has been shown that in the context of India the possibility of connection between the word Nāgaja and the directly smelted lead-tin alloys cannot be ruled out.

  7. People involved in radiation research and protection - an historical perspective

    International Nuclear Information System (INIS)

    Toussaint, L.F.

    2010-01-01

    Full text: The lives of selected people involved in radiation research are covered in two parts: 1. history of radiation and radioactivity; and 2. historical aspects of radiation and radiation protection in Western Australia. History of radiation/radioactivity: The background of some of the key people involved in early radiation research is discussed. These include Rontgen and Becqucrel who undertook early research into X-rays and radioactivity respectively. As well as the radiation hazards which early radiation scientists faced, there were also social pressures, as exemplified by the life of women such as Marie Curie, particularly after the death of her husband Pierre. Despite this being the time of the so-called 'beautiful years' in Europe, where there was a friendly exchange of ideas between scientists from various countries, there were also protracted disagreements. Some of the scientific findings of the Curies' daughter (Irene Joliot-Curie) and husband (Frederic Joliot-Curie) were vigorously disputed by Lisa Meitner (and colleague Otto Hahn) in Vienna. The 'beautiful years' came to an end when politics intruded and scientists such as Lisa Meitner had to flee from persecution. The splitting of the atom and realisation (by Leo Szilard) that a chain reaction was possible, led to political barriers being erected around scientists. With Europe poised for war, the implication of this science for warfare application was cause for concern among many of the normally free thinking and co-operative scientists. Secrecy now prevailed.

  8. The (deMilitarization of Humanitarian Aid: A Historical Perspective

    Directory of Open Access Journals (Sweden)

    Marc-Antoine Pérouse de Montclos

    2014-06-01

    Full Text Available Humanitarian workers often complain that international aid to victims of armed conflicts is more and more militarized because relief organizations are embedded into peacekeeping operations, used as a “force multiplier”, or manipulated as an instrument of diplomacy by proxy. Historically, however, charity has always been a military issue in times of war. We can distinguish four types of militarization of relief organizations in this regard. First is the use of charities to make “war by proxy”, as in Afghanistan or Nicaragua in the 1980s. The second pattern is “embedment”, like the Red Cross during the two world wars. The third is “self-defense”, as with the Order of Saint John of Jerusalem (now Malta in the 12th Century. The fourth, finally, is the model of “International Brigades” alongside the Spanish Republicans in 1936 or various liberation movements in the 1970s. In comparison, humanitarian aid today appears to be much less militarized. However, this perception also depends on the various definitions of the word “humanitarian”.

  9. Symptom research on chronic cough: a historical perspective.

    Science.gov (United States)

    Irwin, R S; Madison, J M

    2001-05-01

    This review provides a perspective on how research on the management of cough has evolved, looks at key methodologic lessons that have been learned from this research and how they may relate to the management of other symptoms, identifies important methodologic challenges that remain to be solved, and lists important questions that still need to be answered. Three important methodologic lessons have been learned. First, cough must be evaluated systematically and according to a neuroanatomic framework. Second, the response to specific therapy must be noted to determine the cause or causes of cough and to characterize the strengths and limitations of diagnostic testing. Third, multiple conditions can simultaneously cause cough. Among the three methodologic challenges that still need to be solved are 1) definitively determining the diagnostic accuracy and reliability of 24-hour esophageal pH monitoring and how best to interpret pH test results, 2) definitively determining the role of nonacid reflux in cough due to gastroesophageal reflux disease, and 3) developing reliable and reproducible subjective and objective methods with which to assess the efficacy of cough therapy. Numerous important clinical questions are still unanswered: What role do empirical therapeutic trials play in diagnosing the cause of chronic cough? What is the most cost-effective approach to the diagnosis and treatment of chronic cough: empirical therapeutic trials or laboratory testing-directed therapeutic trials? How often is environmental air pollution, unrelated to allergies or smoking, responsible for chronic cough?

  10. Separations chemistry for actinide elements: Recent developments and historical perspective

    International Nuclear Information System (INIS)

    Nash, K.L.; Choppin, G.R.

    1997-01-01

    With the end of the cold war, the principal mission in actinide separations has changed from production of plutonium to cleanup of the immense volume of moderately radioactive mixed wastes which resulted from fifty years of processing activities. In order to approach the cleanup task from a proper perspective, it is necessary to understand how the wastes were generated. Most of the key separations techniques central to actinide production were developed in the 40's and 50's for the identification and production of actinide elements. Total actinide recovery, lanthanide/actinide separations, and selective partitioning of actinides from inert constituents are currently of primary concern. To respond to the modern world of actinide separations, new techniques are being developed for separations ranging from analytical methods to detect ultra-trace concentrations (for bioassay and environmental monitoring) to large-scale waste treatment procedures. In this report, the history of actinide separations, both the basic science and production aspects, is examined and evaluated in terms of contemporary priorities

  11. Historical Perspective About the Nursing Care of the Mental Patient

    Directory of Open Access Journals (Sweden)

    Loide Ferreira

    2014-10-01

    Full Text Available The concept of caring in nursing has changed throughout the years. Nursing has developed to meet the needs of the population and to adapt at the same time to scientific knowledge, which has taken another dimension, and technical demand. Every field in nursing gains new formas as it evolves, namely the mental health and psychiatric fields. We start by describing the dominant beliefs of society in the past regarding mental health. We will then talk about mental patients in Portugal from the 16th Century on (1539-1850 and how they were cared for, underlining the first psychiatric institution - Rilhafoles Hospital. We will elaborate on the more common treatments in psychiatry, the purposes they served and how the nursing staff intervened in their application. Finally, we will put the evolution of nursing care to the mental patients into perspective, from the begining of the 20th century, as well as the development of nursing schools in the field of mental and psychiatric health.

  12. Changing tides: ecological and historical perspectives on fish cognition.

    Science.gov (United States)

    Patton, B Wren; Braithwaite, Victoria A

    2015-01-01

    The capacity for specialization and radiation make fish an excellent group in which to investigate the depth and variety of animal cognition. Even though early observations of fish using tools predates the discovery of tool use in chimpanzees, fish cognition has historically been somewhat overlooked. However, a recent surge of interest is now providing a wealth of material on which to draw examples, and this has required a selective approach to choosing the research described below. Our goal is to illustrate the necessity for basing cognitive investigations on the ecological and evolutionary context of the species at hand. We also seek to illustrate the importance of ecology and the environment in honing a range of sensory systems that allow fish to glean information and support informed decision-making. The various environments and challenges with which fish interact require equally varied cognitive skills, and the solutions that fish have developed are truly impressive. Similarly, we illustrate how common ecological problems will frequently produce common cognitive solutions. Below, we focus on four topics: spatial learning and memory, avoiding predators and catching prey, communication, and innovation. These are used to illustrate how both simple and sophisticated cognitive processes underpin much of the adaptive behavioral flexibility exhibited throughout fish phylogeny. Never before has the field had such a wide array of interdisciplinary techniques available to access both cognitive and mechanistic processes underpinning fish behavior. This capacity comes at a critical time to predict and manage fish populations in an era of unprecedented global change. © 2015 John Wiley & Sons, Ltd.

  13. [Swimming, physical activity and health: a historical perspective].

    Science.gov (United States)

    Conti, A A

    2015-01-01

    Swimming, which is the coordinated and harmonic movement of the human body inside a liquid medium by means of the combined action of the superior and inferior limbs, is a physical activity which is diffused throughout the whole world and it is practiced by healthy and non-healthy subjects. Swimming is one of the physical activities with less contraindications and, with limited exceptions, can be suggested to individuals of both sexes and of every age range, including the most advanced. Swimming requires energy both for the floating process and for the anterograde progression, with a different and variable osteo-arthro-muscular involvement according to the different styles. The energetic requirement is about four times that for running, with an overall efficiency inferior to 10%; the energetic cost of swimming in the female subject is approximately two thirds of that in the male subject. The moderate aerobic training typical of swimming is useful for diabetic and hypertensive individuals, for people with painful conditions of rachis, as also for obese and orthopaedic patients. Motor activity inside the water reduces the risk of muscular-tendinous lesions and, without loading the joints in excess, requires the harmonic activation of the whole human musculature. Swimming is an activity requiring multiple abilities, ranging from a sense of equilibrium to that of rhythm, from reaction speed to velocity, from joint mobility to resistance. The structured interest for swimming in the perspective of human health from the beginning of civilization, as described in this contribution, underlines the relevance attributed to this activity in the course of human history.

  14. Promoting astronomy in developing countries: A historical perspective

    Science.gov (United States)

    Kochhar, Rk

    2006-08-01

    Any international effort to promote astronomy world wide today must necessarily take into account its cultural and historical component. The past few decades have ushered in an age, which we may call the Age of Cultural Copernicanism. In analogy with the cosmological principle that the universe has no preferred location or direction, Cultural Copernicanism would imply that no cultural or geographical area, or ethnic or social group, can be deemed to constitute a superior entity or a benchmark for judging or evaluating others. In this framework, astronomy (as well as science in general) is perceived as a multi-stage civilizational cumulus where each stage builds on the knowledge gained in the previous stages and in turn leads to the next. This framework however is a recent development. The 19th century historiography consciously projected modern science as a characteristic product of the Western civilization decoupled from and superior to its antecedents, with the implication that all material and ideological benefits arising from modern science were reserved for the West. As a reaction to this, the orientalized East has often tended to view modern science as "their" science, distance itself from its intellectual aspects, and seek to defend, protect and reinvent "our" science and the alleged (anti-science) Eastern mode of thought. This defensive mindset works against the propagation of modern astronomy in most of the non-Western countries. There is thus need to construct a history of world astronomy that is truly universal and unselfconscious. Similarly , the planetarium programs , for use the world over, should be culturally sensitive. IAU can help produce cultural-specific modules. Equipped with this paradigmatic background, we can now address the question of actual means to be adopted for the task at hand. Astronomical activity requires a certain minimum level of industrial activity support. Long-term maintenance of astronomical equipment is not a trivial task

  15. The Phenological Network of Catalonia: an historical perspective

    Science.gov (United States)

    Busto, Montserrat; Cunillera, Jordi; de Yzaguirre, Xavier

    2017-04-01

    ). Fenocat technicians are also involved in data rescue initiatives that allow the study of historical phenological series. The La Serra d'Almos (near Tarragona) phenological series is an example that shows the life cycle trends for plants and birds observed since 1971. The Phenological Network of Catalonia has marked a turning point in the recording of the rhythms of nature in Catalonia and works to preserve sensitive information for the study of climate change in the fragile Mediterranean ecosystem.

  16. Health care in Nicaragua: a social and historical perspective.

    Science.gov (United States)

    Petrack, E M

    1984-10-01

    To facilitate understanding of the advances in health care in Nicaragua since 1979, this discussion examines them within a historical framework. Nicaragua was occupied by US marines almost continuously from 1909-33. In 1933, their withdrawal left in power the US backed National Guard and the 1st dictator, Anastasio Somoza Garcia. Health conditions under the Somoza regime are difficult to evaluate because lack of data and underreporting were the norm. The health care system under Somoza was administered by 23 separate agencies, including the National Social Security Institute (INSS), a national Ministry of Health, independent local health ministries, and autonomous public hospital governing boards. On July 19, 1979, the dictatorship was overthrown in a popular uprising. Somoza left behind a foreign debt of 1.6 billion dollars, which the Sandinista Front for National Liberation (FSLN) needed to honor to qualify for needed loans. Following Somoza's defeat, the new government faced the problem of how to care for the tens of thousands of persons wounded and how to distribute the aid and medical supplies coming in from other countries. The key to achieving these tasks was popular participation and organization. By the early part of 1980, the new government was addressing more directly the organization of the health care system. Unlike the fragmented services under Somoza, health care in the new Nicaragua fell under the control of a unified Ministry of Health (MINSA). In 1980, the FSLN initiated an intensive campaign against illiteracy, 100,000 young Nicaraguans, called "brigadistas," were trained and sent around the country to teach basic reading and writing. In addition, 1 out of 10 was trained in elementary health principles. They were responsible for educating others about hygiene and basic sanitation as well as distributing antimalarial medication. 5 popular Health Campaigns were waged during 1981 against polio; measles, diphtheria, pertussis, and tetanus; rabies

  17. North American osprey populations and contaminants: Historic and contemporary perspectives

    Science.gov (United States)

    Henny, Charles J.; Grove, Robert A.; Kaiser, James L.; Johnson, Branden L.

    2010-01-01

    Osprey (Pandion haliaetus) populations were adversely affected by DDT and perhaps other contaminants in the United States and elsewhere. Reduced productivity, eggshell thinning, and high DDE concentrations in eggs were the signs associated with declining osprey populations in the 1950s, 1960s, and 1970s. The species was one of the first studied on a large scale to bring contaminant issues into focus. Although few quantitative population data were available prior to the 1960s, many osprey populations in North America were studied during the 1960s and 1970s with much learned about basic life history and biology. This article reviews the historical and current effects of contaminants on regional osprey populations. Breeding populations in many regions of North America showed post-DDT-era (1972) population increases of varying magnitudes, with many populations now appearing to stabilize at much higher numbers than initially reported in the 1970s and 1980s. However, the magnitude of regional population increases in the United States between 1981 (first Nationwide Survey, ∼8,000 pairs), when some recovery had already occurred, 1994 (second survey, ∼14,200), and 2001 (third survey, ∼16,000–19,000), or any other years, is likely not a simple response to the release from earlier contaminant effects, but a response to multi-factorial effects. This indirect “contaminant effects” measurement comparing changes (i.e., recovery) in post-DDT-era population numbers over time is probably confounded by changing human attitudes toward birds of prey (shooting, destroying nests, etc.), changing habitats, changing fish populations, and perhaps competition from other species. The species' adaptation to newly created reservoirs and its increasing use of artificial nesting structures (power poles, nesting platforms, cell towers, channel markers, offshore duck blinds, etc.) are two important factors. The timing of the initial use of artificial nesting structures, which replaced

  18. Assessment of Drought Severity Techniques - A Historical Perspective

    Science.gov (United States)

    Panu, U. S.; Crinklaw, T.

    2011-12-01

    Droughts are natural phenomenon experienced by all nations across the globe. Drought inherently means a scarcity of water, which adversely affects various sectors of human socio-economic spectrum, e.g. agriculture, hydropower generation, water supply, industry, recreation, navigation, fish production etc. The prime cause of droughts is the occurrence of less than optimal (below normal) precipitation, which has its origin to various natural reasons, the most important being the global climatic forcing. Droughts are also referred to as sustained and regionally extensive occurrences of below average water availability which invariably cultivate into environmental disasters. The evolution of a drought event is defined into four types; meteorological, agricultural, hydrological, and socio-economic. Drought affects all aspects of societal systems irrespective of how it is defined. This has led to a wide range of studies conducted by meteorologists, ecologists, environmentalists, hydrologists, geologists and agricultural scientists in attempts to understand drought processes as required to analyze and predict the impacts of droughts. A conceptual definition, such as a shortage of water relied on by human activity, avoids quantification of a drought event. On the other hand, the purpose of an operational definition is to determine the beginning, termination, and severity of a drought event. The severity assessment of droughts is of primary importance for allocation and management of available water resources. The progression and impact of historical droughts in a region is helpful for developing relationships and techniques to investigate relevant characteristics of droughts. For optimum drought preparedness and mitigative responses, professional bodies need to provide information to private and government agencies in a manner that may also be understood by their employers, stakeholders and the general public. Drought indicators bridge this communication gap between all

  19. Brief historical perspective on the definition of high-level nuclear wastes

    International Nuclear Information System (INIS)

    Jacobs, D.G.; Szluha, A.T.; Gablin, K.A.; Croff, A.G.

    1985-03-01

    This report constitutes a historical perspective on the definition of HLW with emphasis on the US situation. The major HLW definitions are summarized chronologically, including a categorization of the considerations (e.g., waste source, heat generation rate, radiological effects) forming the bases of the definitions. High-level waste (HLW) definitions are then discussed in terms of these considerations. A brief discussion of the institutional aspects of HLW regulation and management are presented. An appendix to the report constitutes an annotated, chronological bibliography that formed the basis of the perspective

  20. Woodland caribou management in Alberta: historical perspectives and future opportunities

    Directory of Open Access Journals (Sweden)

    Elston H. Dzus

    2007-04-01

    Full Text Available Woodland caribou conservation has been the topic of much debate for the past few decades. By the late 1970s there was growing concern about declining woodland caribou populations and the interaction between industrial activities and woodland caribou. Initial concerns led to the closure of the licensed hunting season in 1981. Early confrontation between government and industry in the late 1980s transformed into a series of evolving collaborative ventures. Improving our understanding of the basic ecology of woodland caribou in Alberta was at the center of early research efforts; more recent studies have examined the effects of industrial activities on caribou and effectiveness of various mitigation factors. Despite having amassed an impressive body of information from a research and monitoring perspective, progress on implementing effective management actions has been less dramatic. Industry has endured significant costs implementing a variety of perceived conservation initiatives, but caribou populations continued to decline through the last few decades. While some parties feel more research is needed, there is growing consensus that changes to habitat as induced by human activities are important factors influencing current caribou declines. Predation is a proximate cause of most caribou mortality. Climate change mediated alterations to habitat and predator-prey interactions remain a key source of uncertainty relative to future caribou population trends. Management actions will need to deal with long term habitat changes associated with human land use and short term implications of increased predation. In 2005, the provincial minister responsible for caribou conservation responded to the draft 2004 recovery plan and created the Alberta Caribou Committee (ACC. The goal of the ACC is to maintain and recover woodland caribou in Alberta’s forest ecosystems while providing opportunities for resource development, following guidance provided by the

  1. S.M. Guma and the Sesotho historical novel: an Afrocentric perspective

    Directory of Open Access Journals (Sweden)

    T.J. Selepe

    2008-07-01

    Full Text Available Afrocentricity seems to be emerging as one of the potent critical tools that could be used to re-establish and qualify African cultural identity through literary study among others. The primary objective of this movement is to reinterpret world history from an African perspective. This article will therefore examine some historical features of S.M. Guma’s novels from the 1960s to the 1990s from an African perspective. By applying the Afrocentric paradigm this will attempt to demonstrate how material conditions of the period have provided useful raw materials for the Sesotho historical novel, which tends to illuminate a better understanding of the Basotho culture, history, identity and nationhood.

  2. CAPITAL STRUCTURE OF UKRAINIAN NON-FINANCIAL COMPANIES IN HISTORICAL PERSPECTIVE

    Directory of Open Access Journals (Sweden)

    D. Chernenko

    2018-01-01

    Full Text Available This paper examines the dynamics of Ukrainian non-financial firms' capital structure within a historical perspective. It shows that firm financing since 1990 was a derivative from economic and institutional changes, and current levels of leverage are lower than ones of foreign peers. Whereas in the short-term we can expect some market recovery, long-term dynamics relies almost exclusively on the successof institutional reforms.

  3. Energy use in the U.S. steel industry: An historical perspective and future opportunities

    Energy Technology Data Exchange (ETDEWEB)

    Stubbles, John [Steel Industry Consultant, Mason, OH (United States)

    2000-09-01

    Renowned industry expert Dr. John Stubbles has projected the energy savings that the U.S. steel industry could reasonably expect to achieve in the report, Energy Use in the U.S. Steel Industry: Historical Perspective and Future Opportunities (PDF 432 KB). The report examines the potential impacts of state-of-the-art technologies and operating practices, as well as structural changes in the industry itself.

  4. Altruistic cell suicide in relation to radiation hormesis

    International Nuclear Information System (INIS)

    Kondo, Sohei

    1988-01-01

    The high radiosensitivity to killing of undifferentiated primordial cells (Bergonie and Tribondeau 1906) can be described as a manifestation of the suicide of injured cells for the benefit of an organism as a whole if their suicide stimulates proliferation of healthy cells to replace them, resulting in complete elimination of injury. This process is called cell-replacement repair, to distinguish it from DNA repair which is rarely complete. 'Cell suicide', 'programmed death' and 'apoptosis' are terms used for the same type of active cell death. Cell suicide is not always altruistic. Altruistic suicide in Drosophila, mice, humans, plants, and E. coli is reviewed in this paper to illustrate its widely different facets. The hypothesis that in animals, radiation hormesis results from altruistic cell suicide is proposed. This hypothesis can explain the hormetic effect of low doses of radiation on the immune system in mice. In contrast, in plants, radiation hormesis seems to be mainly due to non-altruistic cell death. (author)

  5. Historical perspective of sexually transmitted infections and their control in Peru.

    Science.gov (United States)

    García, P J

    2010-04-01

    In designing an effective national response to sexually transmitted infections (STIs), one must incorporate a historical perspective of previous efforts that have addressed different aspects of STIs. One must understand who have been the key players, what aspects of STIs were the focus of efforts (prevention, treatment or control), and which, if any, societal subgroups were targeted (i.e. sex workers, military, men who have sex with men [MSM], etc.). In addition, one must consider historical and modern attitudes towards sex, sexuality and STIs, especially in terms of taboos and stigmas that may be attached to each. Most importantly, one must recognize which efforts have succeeded, which have failed, and why. This paper presents a historical overview of the perceptions of and responses to STIs at different points in Peru's history, and discusses current efforts to build upon past successes and avoid repeating previous failures that could be helpful for other countries in the Latin American region.

  6. Three Norwegian Varieties of a Nordic Model — A Historical Perspective on Working Life Relations

    Directory of Open Access Journals (Sweden)

    Jan Heiret

    2012-11-01

    Full Text Available Through the use of a historical perspective, the aim of this article is to discuss and clarify the concurrent and conflicting interests and norms that have characterized the establishment and development of important institutions in Norwegian working life. The article concentrates on collective bargaining systems, the arrangements for codetermination, and the working environment regulations in both the public and private sector, which are regarded as the main institutions in the Norwegian and Nordic models of working life relations. The article is structured by an analytical distinction between three different historical periods that have constituted three distinct versions of the Norwegian model. By presenting a historical synthesis of Norwegian experiences, the article is a contribution to the ongoing debate on the varieties in the Nordic model, as to further comparisons and broader transnational studies.

  7. First study of hormesis effect on mushroom cultivation.

    Science.gov (United States)

    Zied, Diego Cunha; Dourado, Fernanda Aparecida; Dias, Eustáquio Souza; Pardo-Giménez, Arturo

    2017-10-05

    The use of fungicides is common in mushroom cultivation, but no study was carried out applying reduced doses of fungicides in order to increase yield, taking account the hormesis effect. The aim of this manuscript was to verify the effects of different concentrations of fungicides to stimulate the productivity of different strains of Agaricus bisporus. Two stages were developed, an in vitro study to define the best concentration to be applied in the second experiment an agronomic study, which consisted of the application of the selected fungicides, in their respective concentrations, in an experiment carried out in the mushroom chamber. Clearly, the result of the hormesis effect on mushroom cultivation can be verified. The results obtained in the 1st stage of the study (in vitro) were not always reproduced in the 2nd stage of the study (in vivo). The kresoxim methyl active ingredient may be an important chemical agent, while strain ABI 15/01 may be an extremely important biological agent to increase yield in the study of hormesis effects.

  8. How prevalent is chemical hormesis in the natural and experimental worlds?

    Energy Technology Data Exchange (ETDEWEB)

    Mushak, Paul, E-mail: pandbmushak@cs.com

    2013-01-15

    Hormesis is described as a biological phenomenon showing bidirectional (biphasic) responses to chemical or other stressors: stimulation at low doses and inhibition at high doses or vice-versa. The label applies to either radiation or chemical hormesis. This review addresses certain critical but persisting quantitative questions about chemical hormesis. For example, what is its actual generalizability in nature? Is hormesis generalizable enough to figure in risk analysis and regulatory efforts within human or ecological toxicant exposures? No evidence exists to show that chemical hormesis is a universally distributed biological phenomenon within some law, rule or principle (100% frequency) nor is there a reliable and consistent body of evidence that leads to identifying some significant and reproducible value for frequency of occurrence below the universality standard, i.e., < 100% frequency. Lack of reliable and/or consistent evidence arises from diverse limits to study methods, i.e., methods were post-hoc evaluations of published data gathered for other purposes and using ad-hoc characterization approaches, rather than doing new studies. The literature selected for generalizability analyses has not been systematically pre-evaluated as a scientifically reliable representation of hormesis frequency in nature. Furthermore, database evaluations have used certain criteria not validated for this specific purpose, so that metric and what was measured are objects of scrutiny and ambiguity. Finally, simultaneous estimates of frequency of non-hormetic dose–response relationships, required for reliable determinations of hormesis frequency, were not done in these analyses. Chemical hormesis frequency estimates vary with conditions for characterization. For all these reasons, chemical hormesis still has limited use in health policy and regulatory thinking. - Highlights: ► Hormesis is not a universally distributed biological phenomenon (100% frequency). ► There is also no

  9. How prevalent is chemical hormesis in the natural and experimental worlds?

    International Nuclear Information System (INIS)

    Mushak, Paul

    2013-01-01

    Hormesis is described as a biological phenomenon showing bidirectional (biphasic) responses to chemical or other stressors: stimulation at low doses and inhibition at high doses or vice-versa. The label applies to either radiation or chemical hormesis. This review addresses certain critical but persisting quantitative questions about chemical hormesis. For example, what is its actual generalizability in nature? Is hormesis generalizable enough to figure in risk analysis and regulatory efforts within human or ecological toxicant exposures? No evidence exists to show that chemical hormesis is a universally distributed biological phenomenon within some law, rule or principle (100% frequency) nor is there a reliable and consistent body of evidence that leads to identifying some significant and reproducible value for frequency of occurrence below the universality standard, i.e., < 100% frequency. Lack of reliable and/or consistent evidence arises from diverse limits to study methods, i.e., methods were post-hoc evaluations of published data gathered for other purposes and using ad-hoc characterization approaches, rather than doing new studies. The literature selected for generalizability analyses has not been systematically pre-evaluated as a scientifically reliable representation of hormesis frequency in nature. Furthermore, database evaluations have used certain criteria not validated for this specific purpose, so that metric and what was measured are objects of scrutiny and ambiguity. Finally, simultaneous estimates of frequency of non-hormetic dose–response relationships, required for reliable determinations of hormesis frequency, were not done in these analyses. Chemical hormesis frequency estimates vary with conditions for characterization. For all these reasons, chemical hormesis still has limited use in health policy and regulatory thinking. - Highlights: ► Hormesis is not a universally distributed biological phenomenon (100% frequency). ► There is also no

  10. Ophthalmology's future in the next decade: a historical and comparative perspective.

    Science.gov (United States)

    Day, S H

    1999-01-01

    To gain a historical and comparative perspective about the future of ophthalmology within the profession of medicine. A literature search is made of disciplines other than medicine (history, sociology, philosophy, economics, and ethics) in order to assess factors responsible for survival and healthiness of a profession. The "learned" professions (medicine, law, and theology) are assessed. Other "professional" careers valued by society (sports and classical music) are reviewed. From the perspective of other disciplines, the future of ophthalmology is seen as vulnerable and fragile. Survival of professions, be they classically or economically defined, is linked to societal needs, a profession's unique commitment and ability to provide services to society, and the profession's maintenance of knowledge as well as skill-based services. Historical evidence has shown erosion of a profession's power consequent to capitalist influences, government influences, access of skills by less trained individuals, and elitist posturing by a profession. Comparative evidence has shown societal acceptance of an escalation of salaries for designated superstars, increasing roles and influence of managerial personnel, and trivialization of values other than economic ones. Attention to historical and comparative trends by individual ophthalmologists as well as associations representing ophthalmologists is mandatory if ophthalmology as we know it is to survive within the profession of medicine.

  11. Clarifying appeals to dignity in medical ethics from an historical perspective.

    Science.gov (United States)

    Van Der Graaf, Rieke; Van Delden, Johannes Jm

    2009-03-01

    Over the past few decades the concept of (human) dignity has deeply pervaded medical ethics. Appeals to dignity, however, are often unclear. As a result some prefer to eliminate the concept from medical ethics, whereas others try to render it useful in this context. We think that appeals to dignity in medical ethics can be clarified by considering the concept from an historical perspective. Firstly, on the basis of historical texts we propose a framework for defining the concept in medical debates. The framework shows that dignity can occur in a relational, an unconditional, a subjective and a Kantian form. Interestingly, all forms relate to one concept since they have four features in common: dignity refers, in a restricted sense, to the 'special status of human beings'; it is based on essential human characteristics; the subject of dignity should live up to it; and it is a vulnerable concept, it can be lost or violated. We argue that being explicit about the meaning of dignity will prevent dignity from becoming a conversation-stopper in moral debate. Secondly, an historical perspective on dignity shows that it is not yet time to dispose of dignity in medical ethics. At least Kantian and relational dignity can be made useful in medical ethics.

  12. Advances for prosthetic technology from historical perspective to current status to future application

    CERN Document Server

    LeMoyne, Robert

    2016-01-01

    This book focuses on the advances in transtibial prosthetic technology and targets research in the evolution of the powered prosthesis such as the BiOM, which was derived from considerable research and development at the Massachusetts Institute of Technology. The concept of the book spans the historical evolution of prosthetic applications from passive to new and futuristic robotic prosthetic technologies.  The author describes the reasons for amputation, surgical procedures, and an historical perspective of the prosthesis for the lower limb. He also addresses the phases and sub-phases of gait and compensatory mechanisms arising for a transtibial prosthesis and links the compensatory mechanisms to long-term morbidities.  The general technologies for gait analysis central to prosthetic design and the inherent biomechanics foundations for analysis are also explored.  The book reports on recent-past to current-term applications with passive elastic prostheses.  The core of the book deals with futuristic robo...

  13. Historical perspective and contemporary management of acute coronary syndromes: from MONA to THROMBINS2.

    Science.gov (United States)

    Kline, Kristopher P; Conti, C Richard; Winchester, David E

    2015-01-01

    Acute coronary syndrome (ACS) remains a major burden on morbidity and mortality in the United States. Medical professionals and students often use the mnemonic 'MONA' (morphine, oxygen, nitroglycerin and aspirin) to recall treatments for ACS; however, this list of therapies is outdated. We provide a historical perspective on 'MONA,' attempt to uncover its origin in the medical literature, and demonstrate the myriad changes that have occurred over the last 50 years of ACS management. We have developed a novel mnemonic, 'THROMBINS2' (thienopyridines, heparin/enoxaparin, renin-angiotensin system blockers, oxygen, morphine, beta blocker, intervention, nitroglycerin, statin/salicylate) to help bedside clinicians recall all the elements of contemporary ACS management. We demonstrate the mortality benefit for each component of contemporary ACS management, correlating the continued improvement with historical data on mortality after myocardial infarction. We encourage providers to utilize this mnemonic to explore options and guide treatments in ACS patients.

  14. Propulsion Control Technology Development in the United States A Historical Perspective

    Science.gov (United States)

    Jaw, Link C.a; Garg, Sanjay

    2005-01-01

    This paper presents a historical perspective of the advancement of control technologies for aircraft gas turbine engines. The paper primarily covers technology advances in the United States in the last 60 years (1940 to approximately 2002). The paper emphasizes the pioneering technologies that have been tested or implemented during this period, assimilating knowledge and experience from industry experts, including personal interviews with both current and retired experts. Since the first United States-built aircraft gas turbine engine was flown in 1942, engine control technology has evolved from a simple hydro-mechanical fuel metering valve to a full-authority digital electronic control system (FADEC) that is common to all modern aircraft propulsion systems. At the same time, control systems have provided engine diagnostic functions. Engine diagnostic capabilities have also evolved from pilot observation of engine gauges to the automated on-board diagnostic system that uses mathematical models to assess engine health and assist in post-flight troubleshooting and maintenance. Using system complexity and capability as a measure, we can break the historical development of control systems down to four phases: (1) the start-up phase (1942 to 1949), (2) the growth phase (1950 to 1969), (3) the electronic phase (1970 to 1989), and (4) the integration phase (1990 to 2002). In each phase, the state-of-the-art control technology is described and the engines that have become historical landmarks, from the control and diagnostic standpoint, are identified. Finally, a historical perspective of engine controls in the last 60 years is presented in terms of control system complexity, number of sensors, number of lines of software (or embedded code), and other factors.

  15. [The Woman and the Care of Life. Historical Understanding and Future Perspectives].

    Science.gov (United States)

    Massé García, M Carmen

    2017-01-01

    Over the ages of humanity, women has established a special relationship life care's with the most vulnerable. Women dedicated to the professional care have always existed, also to the unpaid home care of the sick, elderly, with some disability, and children. This study has been carried out a historical and current verification of this question, marking its most characteristic and significant features. From that perspective, we tried to answer these key questions: causes that have motivated this fact, its social consequences and, finally, the most important future implications for all, men and women that, surely, we will be caregivers and strapped for care in our illness.

  16. ADOLESCENCE IN DEBATE: THEORETICAL CONTRIBUTIONS IN THE LIGHT OF THE HISTORICAL-CULTURAL PERSPECTIVE

    Directory of Open Access Journals (Sweden)

    Candida de Souza

    2018-04-01

    Full Text Available In the studies about adolescence, it is noticeable that psychology has more and more been invited to give answers to questions pertaining this specific period of the human development. The historical-cultural perspective proposed by Lev Semenovich Vygotsky and his followers has represented an important theoretical approach to the comprehension of the human being. Thus, this study aims to offer contributions to the debate about adolescence as a social category and a particular stage of the cultural development of subjects. In this way, the main ideas of this Russian theorist are presented here, incorporating them into the discussion that is still incipient in the studies of the historical-cultural perspective: the role of the body in the constitution of subjects. With this starting point, we build arguments that reinforce the monolithic characteristic of the constitution of the human being, where the mind and the body are inseparable parts of the same gear, that develop together along the lifespan, through the social relations of the individuals with the environmental elements. As final considerations, it is pointed out that the role of the body in the process of developing a conceptual thought – a specific characteristic of adolescence – cannot be neglected when we propose the goal to understand the constitution of the totality of the human psyche.

  17. Transformations over Time or Sudden Change:Historical Perspectives on Mass Migrations and Human Lives

    Directory of Open Access Journals (Sweden)

    Dirk Hoerder

    2012-05-01

    Full Text Available Both migrations and attitudes towards them have deep historical roots. To pronounce the present migration and the economic crisis triggered by derivative bankers in the fall of 2008 as “new without historical precedent” overlooks the impact of patterns of the past on the present and prevents an understanding being reached of continuities and comparisons. It is not migrants who are “uprooted”, as some would have it, but historical memory is deliberately being uprooted. This essay starts by addressing the multiple problems of present-day debates about migration and historicising the perspectives. It critiques the anti-immigrant ascriptions, labels and ideologies. It goes on to present the data and discuss the geographies of migrant trajectories in the context of translocal, transregional, transnational and global connectivity. An integrative Transcultural Societal Studies approach will be proposed. The essay will then deal with migrant agency, that is the actions of migrants, criticising “victimization” approaches and argue that Otherness is a resource as well as a framework for exploitation. Remittances will serve as an example of the intersection between migrant agency and states’ needs. The conclusion will briefly place the present in the context of global inequalities, of the economic aspect and of anti-immigrantism, as well as the ideological national-essentialist aspect.

  18. Paradigm lost, paradigm found: The re-emergence of hormesis as a fundamental dose response model in the toxicological sciences

    Energy Technology Data Exchange (ETDEWEB)

    Calabrese, Edward J. [Environmental Health Sciences, School of Public Health, Morrill I, N344, University of Massachusetts, Amherst, MA 01003 (United States)]. E-mail: edwardc@schoolph.umass.edu

    2005-12-15

    This paper provides an assessment of the toxicological basis of the hormetic dose-response relationship including issues relating to its reproducibility, frequency, and generalizability across biological models, endpoints measured and chemical class/physical stressors and implications for risk assessment. The quantitative features of the hormetic dose response are described and placed within toxicological context that considers study design, temporal assessment, mechanism, and experimental model/population heterogeneity. Particular emphasis is placed on an historical evaluation of why the field of toxicology rejected hormesis in favor of dose response models such as the threshold model for assessing non-carcinogens and linear no threshold (LNT) models for assessing carcinogens. The paper argues that such decisions were principally based on complex historical factors that emerged from the intense and protracted conflict between what is now called traditional medicine and homeopathy and the overly dominating influence of regulatory agencies on the toxicological intellectual agenda. Such regulatory agency influence emphasized hazard/risk assessment goals such as the derivation of no observed adverse effect levels (NOAELs) and the lowest observed adverse effect levels (LOAELs) which were derived principally from high dose studies using few doses, a feature which restricted perceptions and distorted judgments of several generations of toxicologists concerning the nature of the dose-response continuum. Such historical and technical blind spots lead the field of toxicology to not only reject an established dose-response model (hormesis), but also the model that was more common and fundamental than those that the field accepted. - The quantitative features of the hormetic dose/response are described and placed within the context of toxicology.

  19. Paradigm lost, paradigm found: The re-emergence of hormesis as a fundamental dose response model in the toxicological sciences

    International Nuclear Information System (INIS)

    Calabrese, Edward J.

    2005-01-01

    This paper provides an assessment of the toxicological basis of the hormetic dose-response relationship including issues relating to its reproducibility, frequency, and generalizability across biological models, endpoints measured and chemical class/physical stressors and implications for risk assessment. The quantitative features of the hormetic dose response are described and placed within toxicological context that considers study design, temporal assessment, mechanism, and experimental model/population heterogeneity. Particular emphasis is placed on an historical evaluation of why the field of toxicology rejected hormesis in favor of dose response models such as the threshold model for assessing non-carcinogens and linear no threshold (LNT) models for assessing carcinogens. The paper argues that such decisions were principally based on complex historical factors that emerged from the intense and protracted conflict between what is now called traditional medicine and homeopathy and the overly dominating influence of regulatory agencies on the toxicological intellectual agenda. Such regulatory agency influence emphasized hazard/risk assessment goals such as the derivation of no observed adverse effect levels (NOAELs) and the lowest observed adverse effect levels (LOAELs) which were derived principally from high dose studies using few doses, a feature which restricted perceptions and distorted judgments of several generations of toxicologists concerning the nature of the dose-response continuum. Such historical and technical blind spots lead the field of toxicology to not only reject an established dose-response model (hormesis), but also the model that was more common and fundamental than those that the field accepted. - The quantitative features of the hormetic dose/response are described and placed within the context of toxicology

  20. Plant Hormesis Management with Biostimulants of Biotic Origin in Agriculture.

    Science.gov (United States)

    Vargas-Hernandez, Marcela; Macias-Bobadilla, Israel; Guevara-Gonzalez, Ramon G; Romero-Gomez, Sergio de J; Rico-Garcia, Enrique; Ocampo-Velazquez, Rosalia V; Alvarez-Arquieta, Luz de L; Torres-Pacheco, Irineo

    2017-01-01

    Over time plants developed complex mechanisms in order to adapt themselves to the environment. Plant innate immunity is one of the most important mechanisms for the environmental adaptation. A myriad of secondary metabolites with nutraceutical features are produced by the plant immune system in order to get adaptation to new environments that provoke stress (stressors). Hormesis is a phenomenon by which a stressor (i.e., toxins, herbicides, etc.) stimulates the cellular stress response, including secondary metabolites production, in order to help organisms to establish adaptive responses. Hormetins of biotic origin (i.e., biostimulants or biological control compounds), in certain doses might enhance plant performance, however, in excessive doses they are commonly deleterious. Biostimulants or biological control compounds of biotic origin are called "elicitors" that have widely been studied as inducers of plant tolerance to biotic and abiotic stresses. The plant response toward elicitors is reminiscent of hormetic responses toward toxins in several organisms. Thus, controlled management of hormetic responses in plants using these types of compounds is expected to be an important tool to increase nutraceutical quality of plant food and trying to minimize negative effects on yields. The aim of this review is to analyze the potential for agriculture that the use of biostimulants and biological control compounds of biotic origin could have in the management of the plant hormesis. The use of homolog DNA as biostimulant or biological control compound in crop production is also discussed.

  1. Stress and fish reproduction: The roles of allostasis and hormesis

    Science.gov (United States)

    Schreck, C.B.

    2010-01-01

    This paper is a review of the effects of stress on reproduction in fishes. I hope to further the development of the concepts of allostasis and hormesis as relevant to understanding reproduction in general and in fish in particular. The main contentions I derive in this review are the following: Stressors affect fish reproduction in a variety of ways depending on the nature and severity of the stressor. The effects are transduced through a hormonal cascade initiated by perception of the stressor and involving the hypothalamus-pituitary-interrenal axis, the catecholamines, and also cytokines. Mounting a stress response and resisting a stressor is an energetically costly process, including costs associated with allostasis, attempting to reset homeostatic norms. Responses in emergency situations (e.g., being chased by a predator or a net) can be different from those where fish can cope (e.g., being in a more crowded environment) with a stressor, but both situations involve energy re-budgeting. Emergency responses happen in concert with the onset of energy limitations (e.g., the fish may not eat), while coping with allostatic overload can happen in a more energy-rich environment (e.g., the fish can continue to eat). Low levels of stress may have a positive effect on reproductive processes while greater stress has negative effects on fish reproduction. The concept of hormesis is a useful way to think about the effect of stressors on fish reproduction since responses can be nonmonotonal, often biphasic.

  2. Sex specific effects of heat induced hormesis in Hsf-deficient Drosophila melanogaster

    DEFF Research Database (Denmark)

    Sørensen, J G; Kristensen, Torsten Nygård; Kristensen, K V

    2007-01-01

    In insects mild heat stress early in life has been reported to increase life span and heat resistance later in life, a phenomenon termed hormesis. Here, we test if the induction of the heat shock response by mild heat stress is mediating hormesis in longevity and heat resistance at older age...... line, seemingly mediated by the production of heat shock proteins (Hsps). The results indicate that heat inducible Hsps are important for heat induced hormesis in longevity and heat stress resistance. However, the results also suggest that other processes are involved and that different mechanisms...... might have marked sex specific impact...

  3. Hormesis response of marine and freshwater luminescent bacteria to metal exposure

    Directory of Open Access Journals (Sweden)

    KAILI SHEN

    2009-01-01

    Full Text Available The stimulatory effect of low concentrations of toxic chemicals on organismal metabolism, referred to as hormesis, has been found to be common in the widely used luminescence bioassay. This paper aims to study the hormesis phenomenon in both marine and freshwater luminescent bacteria, named Photobacterium phosphorem and Vibrio qinghaiensis. The effects of Cu (II, Zn (II, Cd (II and Cr (VI on luminescence of these two bacteria were studied for 0 to 75 minutes exposure by establishing dose- and time-response curves. A clear hormesis phenomenon was observed in all four testing metals at low concentrations under the condition of luminescence assays.

  4. Sugar Cane Agrobussiness and Traditional Farm in the Northern Plains of Cauca (Colombia). Historical Perspectives and Ethnographic Notes

    OpenAIRE

    Jaramillo Marín, Jefferson; Pontificia Universidad Javeriana (Bogotá, Colombia); Londoño Ortiz, Natalia; Pontificia Universidad Javeriana (Bogotá, Colombia); Sánchez González, Gina; Pontificia Universidad Javeriana (Bogotá, Colombia)

    2015-01-01

    This article reflects in an historical and etnographic key about some of the frictions and links between sugar cain agrobussiness and traditional farm in the northern plains of Cauca, since the mid xx century to the date. The historical perspective allows to trace the consolidation of the sugar cain agroindustrial model. The etnographic approach, describes from the inhabitants narratives some of the socio enviromental conflicts wich are generated by this model in the traditional farm. Both ke...

  5. Johann P. Arnason & Kurt A. Raaflaub, The Roman Empire in Context: Historical and Comparative Perspectives (Chichester: Wiley & Sons, 2011

    Directory of Open Access Journals (Sweden)

    Michael Gibbons

    2012-03-01

    Full Text Available Arnason and Raaflaub’s edited volume, The Roman Empire in Context: Historical and Comparative Perspectives, is the fifth volume in a series entitled The Ancient World: Comparative Histories. The overarching aim of the series is to bring a comparative perspective to studies of ancient histories, and earlier titles focus either on content or geography. This is the only volume to date that focuses on a specific civilization, and Rome is of course significant enough to merit its own volume.

  6. On the concept of “variant” in lexicon studies from a historic-variational perspective

    Directory of Open Access Journals (Sweden)

    Américo Venâncio Lopes Machado Filho

    2014-02-01

    Full Text Available Even though the concept of linguistic variant has been fully established in contemporary sociolinguistic studies, it demands a theoretical review when it is considered from the perspective of lexicon studies, especially when related to historical and variational biases. In this paper, we present limits on identification and characterization of lexical variation, considering formal changes that may occur at other levels of analysis, especially at the morphological or phonetic ones. To support the reflections on the topic, we discuss the process of lexicon constitution in Portuguese and the results of etymological convergence and divergence present in the history of the language. Based on the analysis presented, it is proposed that research on lexical variation should incorporate to this notion any significant formal or content changes.

  7. Hunger strikers: historical perspectives from the emergency management of refugee camp asylum seekers.

    Science.gov (United States)

    Burkle, Frederick M; Chan, Jimmy T S; Yeung, Richard D S

    2013-12-01

    The treatment of hunger strikers is always contentious, chaotic and complex. The management is particularly difficult for health professionals as it raises unprecedented clinical, ethical, moral, humanitarian, and legal questions. There are never any easy answers. The current situation of prisoners from the Iraq and Afghanistan Wars currently at the Guantanamo Bay Detention Center in Cuba demands unprecedented transparency, accountability and multilevel coordination to ensure that the rights of the strikers are properly met. There are scant references available in the scientific literature on the emergency management of these tragedies. This historical perspective documents the complex issues faced by emergency physicians in Hong Kong surrounding refugee camp asylum seekers from Vietnam in 1994 and is offered as a useful adjunct in understanding the complex issues faced by emergency health providers and managers.

  8. Race and ethnicity in the workplace: spotlighting the perspectives of historically stigmatized groups.

    Science.gov (United States)

    Plaut, Victoria C; Thomas, Kecia M; Hebl, Michelle R

    2014-10-01

    Racial and ethnic identity matter and are salient for people in the workplace--a place where people spend a substantial amount of their time. This special issue brings the workplace into the domain of racial and ethnic minority psychology. It also brings to the study of the workplace a relatively neglected perspective: that of people from historically stigmatized racial and ethnic groups. Though there is, of course, need for more work with different themes, outcomes, and populations, this special issue takes us an important step in the direction of understanding better and giving voice to the experiences of racial and ethnic minorities in the workplace. (PsycINFO Database Record (c) 2014 APA, all rights reserved).

  9. Historical and perspectives of thorium compounds production and purification at IPEN-CNEN/SP

    International Nuclear Information System (INIS)

    Lainetti, Paulo E.O.; Abrao, A.; Freitas, Antonio A.; Carvalho, Fatima M.S. de; Bergamaschi, Vanderlei S.; Cunha, Edgar F.; Ayoub, Jamil M.S.; Mindrisz, Ana C.

    2000-01-01

    The production and purification of some thorium compounds has been performed in the IPEN in the last 15 years. Some raw materials have been employed in this production, obtained from the monazite exploitation in industrial scale that it was performed in Sao paulo during the period 1948 until 1994. More than 160 t of high purity thorium nitrate were produced, purified by the solvent extraction process. The thorium nitrate has been supplied for the Brazilian portable gaslight industry to the production of Welsbach Mantle. Nowadays, a new facility is being designed and built. The main concern is the recovering of the production capacity, lost after some years of operation without suitable maintenance. This activity has an important strategic role, considering the huge Brazilian thorium resources and the renewed interest in thorium fuel cycle. This paper describes a brief historical background of thorium activities in the IPEN as well as their perspectives. (author)

  10. Searching for social capital: historical perspectives on health, poverty and culture.

    Science.gov (United States)

    Welshman, John

    2006-11-01

    Social capital has been seen as having a positive effect on health, and the concept of social capital has been viewed as of central importance to debates about healthy, sustainable communities. More generally, behaviour and its relationship with health has become much more central to policy-making, as illustrated in the Choosing Health White Paper (2005), and the concept of social capital has been one influence on the concept of social exclusion. Robert Putnam's arguments, both those expressed in Making Democracy Work (1993) and the revised version seen in Bowling Alone (2000) have been taken up by numerous social scientists and policy-makers. But despite the explicitly historical perspective that Putnam employs in Bowling Alone in particular, the history of social capital remains rather neglected in the available literature. This article is concerned with providing a historical perspective on social capital, especially the ways in which social investigators have viewed the relationships between health, poverty and behaviour. The article puts social capital alongside that of 'underclass' concepts such as the culture of poverty thesis, and examines how the latter has been invented and reinvented in the U.K. and the U.S.A. over the last 120 years. It argues that there are important similarities between the culture of poverty and social capital, but also significant differences, and these have implications for current policy initiatives. One way of analysing concepts like social capital and social exclusion more rigorously is by locating them within this longer-term history of social investigation, in which debates about health, poverty, and culture have been of

  11. Strategy for Self-Centered Development from the Perspective of an Historical Analysis of Development

    Directory of Open Access Journals (Sweden)

    Alfredo Pérez Sánchez

    1998-04-01

    Full Text Available After acknowledging the three phases of historical analysis of development, and especially considering the research work done in the last twenty-five years by the Germans Dieter Sengcheus and Ulrich Mezel, the author presents the principle elements of a self-centered development strategy which highlights the following perspectives:dissociation, economic restructuring, and the new forms of an international division of labor among Third World economies.This document calls into question the underlying operation of the conventional theory of development and its current policy, which call for the increasing integration of the Third World in the world market as a means of going beyond development as it is commonly understood. Though being an integral element in the theory of self-centereddevelopment, temporary dissociation from the world market is proposed. The justification for the strategy of dissociation, excepting the recourse to some historical and paradigmatic reflections sketched by Friedrich List, has kept itself, of necessity, to the global and abstract level. This position is nothing, however, but a most direct analytical result deduced fromthe principle theoretical beginnings and the empirical observations of both the Theory of Dependence and Peripheral Capitalism. Although the review vents its criticism on (and mainly questions the practicality of the aforesaid conception, a more penetratingunderstanding of what the wager for such a strategy entails is found. Thus, the notion of self-centered development influences and gives impulse to a most extensive ideologicallymarked debate about the alternative conceptions of development.

  12. Heritage Conservation and Urban Landscaping of Ancient Pan Pool Neighborhood, Qufu: a Historical and Indigenous Perspective

    Directory of Open Access Journals (Sweden)

    Yingchun Zhang

    2014-12-01

    Full Text Available Gu Pan Pool neighborhood got its name because of Gu Pan Chi, (古泮池,the ancient Pan Pool, located in the southeastern part of Confucius’ birthplace, Qufu, the birth place of Confucius with a history of 3000 year. Gu Pan Pool has been recently under preservation with the joint efforts of World Bank cultural heritage conservation project and the local municipal government. With disparate interests in mind, the three stakeholders of heritage, the world bank, Qufu municipal government and local residents are contradictory with each other in the regeneration process, in which the local voices are often ignored. The purpose of this paper is to rethink heritage making from a historical and indigenous perspective in the contemporary Chinese urban historic landscape planning process. The author contends that the cultural value and pluralism embedded in the ritual way of thinking in Chinese Classics inherited and transmitted for thousands of years could be an alternative way of thinking for the landscape planning practices in the homogenizing culture of global capitalism. This research aims to reinterpret and re-activate Confucianism as cultural heritage to enrich the understanding and hence the sustainability related to human action in urban spaces with emphasis on planning processes in contemporary China.

  13. Medical dominance in Canada in historical perspective: the rise and fall of medicine?

    Science.gov (United States)

    Coburn, D; Torrance, G M; Kaufert, J M

    1983-01-01

    Freidson's concept of medical dominance is compared to the alternative conceptions of neo-Marxist writers. Dominance is then examined in historical perspective, using medicine in Canada (mainly Ontario) as a case study. Medicine emerged as the dominant health occupation in Canada in the late 19th and early 20th centuries, consolidating its power between World War I and the Saskatchewan doctors' strike of 1962. The authors argue that medical dominance has declined since that time due to such factors as the involvement of the state in health insurance, the rise of other health occupations, increasing public or at least elite skepticism, and possible internal fragmentation. The underlying social explanation for this historical process is sought in changes in the Canadian class structure, specifically the spread of the capitalist mode of production, the decline of the petite bourgeoisie, and the rise of the state. It is suggested that Freidson's specific accounts of the history of medicine must be incorporated for explanatory purposes within the broader neo-Marxist view of medicine as an intermediary rather than an ultimately determining institution.

  14. Radiation hormesis: Beneficial effects of exposure to low levels of ionizing radiation. A critical review

    International Nuclear Information System (INIS)

    Koch, J.; Schlesinger, T.

    2002-01-01

    Hormesis is defined as the stimulating effect of low doses of agents that cause an inhibiting effect at high doses. The hormesis hypothesis states that most chemical and physical agents may stimulate biological effects at doses lower than a threshold, while they are toxic at doses higher than this threshold. Since the eighties of the nineties century multiple evidences of hormetic responses have been reported in the scientific literature

  15. Avaliação da cultura do milho submetida à hormesis

    OpenAIRE

    Sousa, Saulo Fernando Gomes de [UNESP; Silva, Paulo Roberto Arbex [UNESP; Benez, Sérgio Hugo [UNESP

    2014-01-01

    Under conservation tillage systems is critical to maintaining plant residues from previous crops on the soil surface. A technique called Hormesis aims to increase the amount of straw and also cause a delay in straw decomposition. Therefore, this study aimed to evaluate the agronomic characteristics of corn under no-tillage system subjected to Hormesis. The experiment was carried out at UNESP campus in the city of Botucatu, SP . The experimental was design in completely randomized blocks. The ...

  16. Modernity Strikes Back? A Historical Perspective on the Latest Increase in Interpersonal Violence (1960–1990

    Directory of Open Access Journals (Sweden)

    Manuel Eisner

    2008-11-01

    Full Text Available There is a plethora of criminological explanations why criminal violence increased during the three decades between the early 1960s and the early 1990s. This paper argues that most available interpretations are lacking in three respects: they lack a historical perspective that anchors the three critical decades in a wider understanding of long-term trends; they take the nation-state as their unit of analysis and disregard important commonalities across the Western world; and they pay insufficient attention to different trends in broad categories of physical violence. This paper therefore takes a macro-level and long-term perspective on violent crime, focussing on European homicide during the past 160 years. It demonstrates that the period of increase was preceded by a long-term decline and convergence of homicide rates from the 1840s to the 1950s. Also, it shows that both the decline and the increase primarily resulted from temporal variation in the likelihood of physical aggression between men in public space. It argues that explanations of these common trends need to take into account broad long-term cultural change common to Western societies. In particular, the paper suggests that shifts in culturally transmitted and institutionally embedded ideals of the conduct of life may provide an explanation for long-term change in levels of interpersonal violence.

  17. Hormesis as a mechanistic approach to understanding herbal treatments in traditional Chinese medicine.

    Science.gov (United States)

    Wang, Dali; Calabrese, Edward J; Lian, Baoling; Lin, Zhifen; Calabrese, Vittorio

    2018-04-01

    Traditional Chinese medicine (TCM) has been long practiced and is becoming ever more widely recognized as providing curative and/or healing treatments for a number of diseases and physiological conditions. This paper posits that herbal medicines used in TCM treatments may act through hormetic dose-response mechanisms. It is proposed that the stimulatory (i.e., low dose) and inhibitory (i.e., high dose) components of the hormetic dose response correspond to respective "regulating" and "curing" aspects of TCM herbal treatments. Specifically, the "regulating" functions promote adaptive or preventive responses, while "curing" treatments alleviate the clinical symptoms. Patterns of hormetic responses are described, and the applicability of these processes to herbal medicines of TCM are explicated. It is noted that a research agenda aimed at elucidating these mechanisms and patterns would be expansive and complex. However, we argue its value, in that hormesis may afford something akin to a Rosetta Stone with which to interpret, translate, and explain TCM herbology in ways that are aligned with biomedical perspectives that could enable a more integrative approach to medicine. Copyright © 2017 Elsevier Inc. All rights reserved.

  18. Hormesis, epitaxy, the structure of liquid water, and the science of homeopathy.

    Science.gov (United States)

    Mastrangelo, Domenico

    2007-01-01

    According to the western medical establishment, homeopathy is both "unscientific" and "implausible". A short overview of its history and the methods it uses, however, easily reveals that homeopathy is a true science, fully grounded on the scientific method and on principles, such as, among others, the Arndt-Schultz law, hormesis, and epitaxy, whose plausibility has been clearly and definitely demonstrated in a number of scientific publications and reports. Through a review of the scientific literature, an explanation of the basic principles of homeopathy is proposed based on arguments and evidence of mainstream science to demonstrate that, in spite of the claims of conventional medicine, homeopathy is both scientific and plausible and that there is no reasonable justification for its rejection by the western medical establishment. Hopefully, this hurdle will be overcome by opening academic institutions to homeopathy to enlarge the horizons of medical practice, recover the value of the human relationship with the patient, and through all this, offer the sick a real alternative and the concrete perspective of an improved quality of life.

  19. The Adoption of Smoking and Its Effect on the Mortality Gender Gap in Netherlands : A Historical Perspective

    NARCIS (Netherlands)

    Janssen, Fanny; van Poppel, Frans

    2015-01-01

    We examine in depth the effect of differences in the smoking adoption patterns of men and women on the mortality gender gap in Netherlands, employing a historical perspective. Using an indirect estimation technique based on observed lung cancer mortality from 1931 to 2012, we estimated lifetime

  20. The Adoption of Smoking and Its Effect on the Mortality Gender Gap in Netherlands: A Historical Perspective

    NARCIS (Netherlands)

    Janssen, F.; van Poppel, F.W.A.

    2015-01-01

    We examine in depth the effect of differences in the smoking adoption patterns of men and women on the mortality gender gap in Netherlands, employing a historical perspective. Using an indirect estimation technique based on observed lung cancer mortality from1931 to 2012, we estimated lifetime

  1. Effect of Photon Hormesis on Dose Responses to Alpha Particles in Zebrafish Embryos

    Directory of Open Access Journals (Sweden)

    Candy Yuen Ping Ng

    2017-02-01

    Full Text Available Photon hormesis refers to the phenomenon where the biological effect of ionizing radiation with a high linear energy transfer (LET value is diminished by photons with a low LET value. The present paper studied the effect of photon hormesis from X-rays on dose responses to alpha particles using embryos of the zebrafish (Danio rerio as the in vivo vertebrate model. The toxicity of these ionizing radiations in the zebrafish embryos was assessed using the apoptotic counts at 20, 24, or 30 h post fertilization (hpf revealed through acridine orange (AO staining. For alpha-particle doses ≥ 4.4 mGy, the additional X-ray dose of 10 mGy significantly reduced the number of apoptotic cells at 24 hpf, which proved the presence of photon hormesis. Smaller alpha-particle doses might not have inflicted sufficient aggregate damages to trigger photon hormesis. The time gap T between the X-ray (10 mGy and alpha-particle (4.4 mGy exposures was also studied. Photon hormesis was present when T ≤ 30 min, but was absent when T = 60 min, at which time repair of damage induced by alpha particles would have completed to prevent their interactions with those induced by X-rays. Finally, the drop in the apoptotic counts at 24 hpf due to photon hormesis was explained by bringing the apoptotic events earlier to 20 hpf, which strongly supported the removal of aberrant cells through apoptosis as an underlying mechanism for photon hormesis.

  2. Resurgence of malaria in Bombay (Mumbai) in the 1990s: a historical perspective.

    Science.gov (United States)

    Kamat, V

    2000-06-01

    Bombay has achieved extraordinary success in controlling its malaria problem for nearly six decades by relying primarily on legislative measures and non-insecticidal methods of mosquito abatement. In 1992, however, malaria reemerged in Bombay with a vengeance. During 1992-1997, the city witnessed a manifold increase in the number of malaria cases diagnosed and treated by the public health system. The large number of malaria patients treated by private practitioners was not recorded by the municipal malaria surveillance system during this period. In 1995, at the peak of the resurgence, public health officials of the Municipal Corporation of Greater Bombay (MCGB) confirmed that 170 persons in the city had died due to malaria. The crisis was unprecedented in Bombay's modern public health history. In response to intense criticism from the media, the city's public health officials attributed the resurgence to the global phenomenon of mosquito-vector resistance to insecticides, and Plasmodium resistance to antimalarial chemoprophylaxis and treatment. Local scientists who investigated the problem offered no support to this explanation. So what might explain the resurgence? What factors led the problem to reach an epidemic level in a matter of two or three years? In addressing the above principal questions, this paper adopts a historical perspective and argues that in the resurgence of malaria in Bombay in the 1990s, there is an element of the 'presence of the past'. In many ways the present public health crisis in Bombay resembles the health scenario that characterized the city at the turn of the 19th century. It is possible to draw parallels between the early public health history of malaria control in Bombay, which was punctuated by events that followed the bubonic plague epidemic of 1896, and the present-day malaria epidemic punctuated by the threat of a plague epidemic in 1994. As such, the paper covers a long period, of almost 100 years. This time-depth is used to

  3. Spa Treatment (Balneotherapy) for Fibromyalgia—A Qualitative-Narrative Review and a Historical Perspective

    Science.gov (United States)

    Ablin, Jacob N.; Buskila, Dan

    2013-01-01

    Aim. To perform a narrative review of spa therapy for management of the fibromyalgia syndrome (FMS), evaluating this traditional time-honored form of therapy in a historical perspective. Methods. Medline was searched using the terms “Spa therapy,” “Balneotherapy,” and “Fibromyalgia” between 1990 (year of ACR fibromyalgia criteria publication) and April 2013. The Cochrane database was also searched. Publications relating to the implementation of spa therapy and related practices over the centuries were identified through references, searched, and reviewed. Results. Reports of balneotherapy were described from diverse locations throughout Europe and Asia, and various forms of water-related therapy have been incorporated for many musculoskeletal indications. In the management of FMS, spa therapy has generally been shown to be well accepted and moderately effective for symptom reduction. Conclusion. While achieving high-quality evidence-based conclusions is difficult for complex natural therapies such as spa therapy, the existing evidence indicates a positive effect in management of FMS. In view of the long history of this modality in the management of rheumatic pain as well as the inherent difficulties related to pharmacological treatment, the role of spa therapy should currently be recognized as part of a therapeutic program for FMS. PMID:23983795

  4. Spa Treatment (Balneotherapy for Fibromyalgia—A Qualitative-Narrative Review and a Historical Perspective

    Directory of Open Access Journals (Sweden)

    Jacob N. Ablin

    2013-01-01

    Full Text Available Aim. To perform a narrative review of spa therapy for management of the fibromyalgia syndrome (FMS, evaluating this traditional time-honored form of therapy in a historical perspective. Methods. Medline was searched using the terms “Spa therapy,” “Balneotherapy,” and “Fibromyalgia” between 1990 (year of ACR fibromyalgia criteria publication and April 2013. The Cochrane database was also searched. Publications relating to the implementation of spa therapy and related practices over the centuries were identified through references, searched, and reviewed. Results. Reports of balneotherapy were described from diverse locations throughout Europe and Asia, and various forms of water-related therapy have been incorporated for many musculoskeletal indications. In the management of FMS, spa therapy has generally been shown to be well accepted and moderately effective for symptom reduction. Conclusion. While achieving high-quality evidence-based conclusions is difficult for complex natural therapies such as spa therapy, the existing evidence indicates a positive effect in management of FMS. In view of the long history of this modality in the management of rheumatic pain as well as the inherent difficulties related to pharmacological treatment, the role of spa therapy should currently be recognized as part of a therapeutic program for FMS.

  5. Analysing young children’s thinking about natural phenomena: A sociocultural/cultural historical perspective

    Directory of Open Access Journals (Sweden)

    JILL ROBBINS

    2009-01-01

    Full Text Available Vygotsky’s sociocultural/cultural historical theory emphasised the notion of semiotic mediation – or how thinking is transformed through signs (such as language and cultural tools (such as drawings from an intermental to an intramental plane. While the ideas of Vygotsky have become well-accepted within research in early childhood education in Australia, they are somewhat slower to be adopted within science education research. Yet they offer the potential for gaining new understandings of how young children’s thinking about the world develops. This article will demonstrate one way in which aspects of Vygotsky’s (1987-1999 work, particularly his ideas about semiotic mediation can inform analysis of children’s thinking about the world. Focusing on conversations with children about natural phenomena, and drawings they completed during those conversations, the analysis identifies a number of significant issues that are not normally revealed within the dominant forms of analysis which draw on constructivist perspectives. The findings, which reveal complex and dynamic aspects of children’s thinking, have implications for both teachers and researchers working with young children – especially within science education and science education research.

  6. Measuring retrograde autobiographical amnesia following electroconvulsive therapy: historical perspective and current issues.

    Science.gov (United States)

    Semkovska, Maria; McLoughlin, Declan M

    2013-06-01

    Retrograde amnesia following electroconvulsive therapy (ECT) is a major concern for both patients and clinicians. In contemporary ECT research, retrograde autobiographical amnesia (RAA) is commonly measured with instruments assessing autobiographical memory (AM) consistency over time. However, normal AM recall loses in consistency with the passage of time, and time has a differential effect on stability of personal memories. In addition, experiencing depression is associated with a decreased ability to recall specific AMs, and this difficulty may persist in the euthymic phase of recurrent depression. Despite these scientific facts, relatively few attempts have been made to accurately measure the specific effect of ECT on AM independent of both normal and mood-associated forgetting over time. This major gap in our knowledge prevents us at present from objectively quantifying the nature and extent of RAA associated with ECT. In turn, this hinders our identifying and implementing strategies for prevention or remediation of AM deficits. The present article aims to provide an up-to-date review and historical perspective of this major methodological conundrum for ECT research, highlight current issues in retrograde amnesia assessment following ECT, and propose directions for future studies. In conclusion, we suggest methods to reliably and specifically measure the extent and progression over time of ECT-associated RAA independently from persistent depressive symptoms' contribution and normal loss in AM consistency over time.

  7. Portfolio Risk of International Diversification of Kosovo Pension Fund: A Historical Perspective

    Directory of Open Access Journals (Sweden)

    Florin Aliu

    2017-01-01

    Full Text Available Finance do not stand on static variables like exact sciences, they are changeable and influenced from human actions. The question where to invest funds, is a crucial task for financial managers. The study aimed at assessing the portfolio risk of different asset managers of the Kosovo Pension and Saving Trust. In general, the assessment has been categorized in two historical perspectives. The first phase is an assessment of the portfolio risk of the fund from 2003 to 2009 and the second phase is from 2003 to 2013. In general, portfolio risk in the second stage has shown a reduction as compared to the first stage. However, the return side shows also a reduction in the second phase than the first one. The overall risk of Kosovo Pension and Saving Trust has been in accepted range. Majority of money have been invested in stocks which automatically exposes huge risk on KPST portfolio, since it is proven that financial markets are not stable and they are prone to asset bubbles.

  8. THE ROLE PLAY AND THE CHILD WITH AUTISM IN THE HISTORICAL-CULTURAL PERSPECTIVE

    Directory of Open Access Journals (Sweden)

    Maria Angélica da Silva

    2017-09-01

    Full Text Available This article aims to analyze the play of make-believe for children with autism, focusing on the symbolic resources it uses in asserting roles. It is based on the theoretical contributions of the historical-cultural perspective, with Vygotsky as its main exponent. The research was carried out in a public school of Early Childhood Education, in Brasília. From the microgenetic analysis, the research had six children diagnosed with autism, at the ages of 4 and 6 years, included in Special Class, as participants. The play situations were videotaped and later transcribed in episode format. In the data analysis, we identified two axes, namely: 1 The construction of the role play and; 2 Assumption of roles by the child with autism: set design and imagery resources. The results reveal the role of the other (intentional participation in the constitution of play activity, especially the role of the adult. In addition, they demonstrate that pedagogical mediation, including the creation of 'scenarios', is fundamental for the extension of the symbolic experience of the child with autism.

  9. From "ES-like" cells to induced pluripotent stem cells: a historical perspective in domestic animals.

    Science.gov (United States)

    Koh, Sehwon; Piedrahita, Jorge A

    2014-01-01

    Pluripotent stem cells such as embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) provide great potential as cell sources for gene editing to generate genetically modified animals, as well as in the field of regenerative medicine. Stable, long-term ESCs have been established in laboratory mouse and rat; however, isolation of true pluripotent ESCs in domesticated animals such as pigs and dogs have been less successful. Initially, domesticated animal pluripotent cell lines were referred to as "embryonic stem-like" cells owing to their similar morphologic characteristics to mouse ESCs, but accompanied by a limited ability to proliferate in vitro in an undifferentiated state. That is, they shared some but not all the characteristics of true ESCs. More recently, advances in reprogramming using exogenous transcription factors, combined with the utilization of small chemical inhibitors of key biochemical pathways, have led to the isolation of iPSCs. In this review, we provide a historical perspective of the isolation of various types of pluripotent stem cells in domesticated animals. In addition, we summarize the latest progress and limitations in the derivation and application of iPSCs. Copyright © 2014 Elsevier Inc. All rights reserved.

  10. Profiles in chemistry: a historical perspective on the national organic symposium.

    Science.gov (United States)

    Fenlon, Edward E; Myers, Brian J

    2013-06-21

    This perspective delineates the history of the National Organic Chemistry Symposium (NOS) and, in doing so, traces the development of organic chemistry over the past 88 years. The NOS is the premier event sponsored by the ACS Division of Organic Chemistry (ORGN) and has been held in odd-numbered years since 1925, with the exceptions of 1943 and 1945. During the 42 symposia, 332 chemists have given 549 plenary lectures. The role the NOS played in the launch of The Journal of Organic Chemistry and Organic Reactions and the initiation of the Roger Adams Award are discussed. Representative examples highlighting the chemistry presented in each era are described, and the evolution of the field is examined by assigning each NOS talk to one of seven subdisciplines and analyzing how the number of talks in each subdiscipline has changed over time. Comparisons of the demographics of speakers, attendees, and ORGN members are made, and superlatives are noted. Personal interest stories of the speakers are discussed, along with the relationships among them, especially their academic lineage. Logistical aspects of the NOS and their historical trends are reviewed. Finally, the human side of science is examined, where over the past century, the NOS has been intertwined with some of the most heated debates in organic chemistry. Conflicts and controversies involving free radicals, reaction mechanisms, and nonclassical carbocations are discussed.

  11. The history of the Russian Orthodox Church in Denmark (1741-2016 seen in a Danish-Russian historical perspective

    Directory of Open Access Journals (Sweden)

    Christensen Carsten Sander

    2017-07-01

    Full Text Available The article deals with the history and the problems of the Russian Orthodox Church in Denmark – and here seen in a Danish-Russian historical perspective, especially, in the last 300 years. The relations between the Danes and the Orthodox Church began, however, around 900 years before, in the Eastern European state of Kievan Rus. The article shows that the history of the church is closely linked to the political development in Russia. In this article, the history of the church and the changing Russian congregations will be illuminated in a historical perspective so that both the church and church buildings will throw a new light on the role of the Russian Church in both Danish and Russian history. In addition, it will be analysed to what extent trade policy, strategy and power policy and family relations have influenced the role and position of the Russian Church in Danish history.

  12. The study of hormesis effection on mice by Zuibyougan

    International Nuclear Information System (INIS)

    Ishii, Takeshi; Nishina, Kazunari.

    1997-01-01

    Although various biohazards of high-dose radiation have been known, Dr. Lucky (1980) paid an attention to low-dose radiation and reported that a low-dose exposure which allows normal functioning of cellular repairing mechanism caused some favorable effects such as growth stimulation, elongation of life-span etc. And these effects were named as Hormesis effects by him. In this study, the biological effects of Zuibyougan, a ionizing radioactive rock produced from a mine were investigated on the growth and locomotor activities in TRC mice. Drinking water containing Zuibyougan in 3 different forms (chip, sand and fine powder) at a concentration of 25 g/100 ml was administered from the time of weaning and tap water was given to the control group. Their body weights were measured once a week up to 12 weeks of age. Body weight of the group administered with either type of Zuibyougan was slightly higher than that of the control. The increasing effects were most marked for the group given in powder form. However, the effects were not statistically significant. Further, the locomotive activities determined by round running method were also slightly higher in the mice administered with Zuibyougan. (M.N.)

  13. Ringhals unit 3 and 4 - Fluence determination in a historic and future perspective

    Energy Technology Data Exchange (ETDEWEB)

    Green, E.L. [Primary Systems Inspection and Repair, Vattenfall/Ringhals AB, 432 85 Vaeroebacka (Sweden); Rouden, J. [Material and Analytical Services, Vattenfall/Ringhals AB, 432 85 Vaeroebacka (Sweden); Efsing, P. [Materials Mechanics, Research and Nuclear Development, Vattenfall/Ringhals AB, 432 85 Vaeroebacka (Sweden)

    2011-07-01

    Document available in abstract form only, full text of document follows: The Ringhals site is situated on the Swedish southwest coastline. At the site, there are four operating nuclear power plants. Historically, the Swedish policy has been that the nuclear power plants were to be closed in 2010. The present position is to operate the units until their technical and economic lifetime has run out. The units shall be maintained and invested in to ensure a lifetime of at least 50 years, but the actions taken shall not limit the time to this date. When the initial surveillance capsules were evaluated, it was noted that the material properties of the weld material of unit 3 and 4 showed some deviations from the expected behaviour. Currently there is an extensive project running for re-evaluating the embrittlement situation from a long-term operating perspective. One part of the project is aimed at more accurately determining the fluence levels of the reactor pressure vessels (RPVs). The basis for the early evaluations of the dosimeters in the surveillance capsules and the corresponding fluence evaluation had an operating lifetime of 25 years as a target value. Therefore, the accuracy and refinement of the measurement and calculation were taken to be good enough to suit this life span. Looking back at the results from the dosimetry measurements there are a few discrepancies. Some of the dosimeters were disintegrated and some measurements had comparatively large uncertainties. When starting this project there were some re-evaluations done with the old fluence prediction model. For every new run and refinement there appeared new difficulties, and the decision was to start the evaluation from scratch. Then there are two questions remaining regarding the fluence: What is the current fluence level? What will the resulting fluence be after 60 years of operation, when we have up-rated output power of both reactors? This paper aims to describe the view of the fluence evaluation

  14. Hormesis-based anti-aging products: a case study of a novel cosmetic

    DEFF Research Database (Denmark)

    Rattan, Suresh; Kryzch, Valerie; Schnebert, Sylvianne

    2013-01-01

    in reducing the age-related accumulation of molecular damage. For example, repeated heat stress-induced synthesis of heat shock proteins has been shown to have a variety of anti-aging effects on growth and other cellular and biochemical characteristics of normal human skin fibroblasts, keratinocytes...... and cosmeceuticals. Here we present the example of a skin care cosmetic as one of the first successful product developments incorporating the ideas of hormesis. This was based on the studies to analyse the molecular effects of active ingredients extracted from the roots of the Chinese herb Sanchi (Panax notoginseng...... and removal of abnormal proteins. Acceptance of such a hormesis-based product by the wider public could be instrumental in the social recognition of the concept of hormesis as the beneficial effects of mild stress of choice, and will encourage the development of novel health care products with physical...

  15. RELIGION AND BANKING SYSTEM: THE FUTURE OF SYARIAH BANKING PRACTICES Historical and Contemporary Fiqh Perspectives

    Directory of Open Access Journals (Sweden)

    Hamka Siregar

    2014-12-01

    Full Text Available The momentum of the development of Sharia banking has been noticed since the 1970s, which generally had two patterns: first, establishing the Islamic bank side by side with conventional one (dual-banking system as practiced in Egypt, Malaysia, Saudi Arabia, Jordan, Kuwait, Bahrain, and Bangladesh; and second, restructuring the banking system as a whole in accordance with Islamic Sharia (full-fledged Islamic financial system as applied in Sudan, Iran and Pakistan. The development of the Sharia-based banks which have been established across the world since the 1970s, became the motivation of the Indonesian ulemas to draft law on Sharia banking, so that Sharia banking could also be developed. As a result, these last few years, the banking world in Indonesia has witnessed the establishment of the public Sharia banks and Sharia business units, like Bank Muamalat and Bank Syariah Mandiri to mention a few. Using historical and contemporary jurisprudence perspective, this paper provides discussion on the future of Sharia banking.

  16. Controlling our destinies: Historical, philosophical, social and ethical perspectives on the Human Genome Project: Final report, July 1, 1995-June 30, 1996

    Energy Technology Data Exchange (ETDEWEB)

    Sloan, P.R.

    1996-09-25

    This report briefly describes the efforts by the organizing committee in preparation for the conference entitled Controlling Our Destinies: Historical, Philosophical, Social, and Ethical Perspectives on the Human Genome Project. The conference was held October 5-8, 1995.

  17. Radiation hormesis using an x-ray radiography device. The fourth report. Radiation hormesis of salad rocket

    International Nuclear Information System (INIS)

    Sakuma, Atsushi; Nakayama, Miho

    2006-01-01

    Radiation hormesis was studied for salad rocket plant (Eruca vesicaria sp.sativa), using different energies of X-ray (100 kV and 10 MV). To get the optimum dose for plant to provide the highest growth, the dose for the seeds was changed from 0 to 3000 mGy using 100 kV of X-ray. The highest growth of the plant was found for the dose of 600 mGy. When the seeds were irradiated to 600 mGy with 100 kV and 10 MV X-rays, in both cases, the growth of the irradiated seeds was higher than those without irradiation, where P-values were 0.0112 and 0.0214, respectively. In the case of 600 mGy irradiation, there was not any significant change in the plant growth between the seeds irradiated with 10 MV and 100 kV X-ray (P=0.862). (author)

  18. Stress to the Rescue: Is Hormesis a ‘Cure’ For Aging?

    DEFF Research Database (Denmark)

    Kahn, Arnold; Olsen, Anders

    2009-01-01

    Despite the fact that the phenomenon of hormesis has been known for many years it is still very much an area of controversy just how useful hormetic treatments are in preventing age-related human diseases and increasing life expectancy. Since there are no data in humans demonstrating hormesis...... as an effective anti-ageing strategy we turn to a simple model organism for insight. In this review we explore what can be predicted about the usefulness of hormetic treatments in humans based upon studies conducted in the soil nematode Caenorhabditis elegans....

  19. Subsidiary historical disciplines at Yugoslav and Serbian universities: Their development and perspectives

    Directory of Open Access Journals (Sweden)

    Atlagić Marko P.

    2013-01-01

    Full Text Available Subsidiary historical disciplines are an important segment of the studies of history without which the history cannot achieve its main methodological goal. They are available for the purpose of history and historical scientific research. Also, they are of an immense importance for collecting and examining historical sources that is for heuristics. At the same time they are relevant for the judgment regarding choosing, valorization and the use of historical sources, namely for historical critique. In the modern period of the development of teaching history at the universities, subsidiary historical disciplines were consisted mostly of Latin paleography, diplomatics and chronology. Since teaching at universities is being developed, the extension of subsidiary historical disciplines is also being slowly spread on sphragistics and numismatics so that nowadays they include Latin paleography, Slavic paleography, epigraphic, filigranology, diplomatics, chronology, genealogy, sphragistics, numismatics, historical metrology, toponomastics with topography and vexillology. Subsidiary historical disciplines became a part of the programmes for studying history at the end of the XVIII century while they were completely affirmed during the XIX century. However, that practice was not included in Yugoslav and especially not in Serbian universities where subsidiary historical disciplines should have been given the first place in the programmes for studying history as well as in their practical use.

  20. Stopping the "Flow of Co-Eds and Other Female Species": A Historical Perspective on Gender Discrimination at Southern (U.S.) Colleges and Universities

    Science.gov (United States)

    McCandless, Amy Thompson

    2009-01-01

    The interrelated nature of gender and racial constructs in the culture of the southern United States accounts for much of the historical prejudice against coeducation in the region's institutions of higher education. This essay offers a historical perspective on gender discrimination on the campuses of Southern universities from the attempts to…

  1. Evidence for beneficial low level radiation effects and radiation hormesis

    International Nuclear Information System (INIS)

    Feinendegen, L.E.

    2005-01-01

    Low doses in the mGy range cause a dual effect on cellular DNA. One effect concerns a relatively low probability of DNA damage per energy deposition event and it increases proportional with dose, with possible bystander effects operating. This damage at background radiation exposure is orders of magnitudes lower than that from endogenous sources, such as ROS. The other effect at comparable doses brings an easily obeservable adaptive protection against DNA damage from any, mainly endogenous sources, depending on cell type, species, and metabolism. Protective responses express adaptive responses to metabolic perturbations and also mimic oxygen stress responses. Adaptive protection operates in terms of DNA damage prevention and repair, and of immune stimulation. It develops with a delay of hours, may last for days to months, and increasingly disappears at doses beyond about 100 to 200 mGy. Radiation-induced apoptosis and terminal cell differentiation occurs also at higher doses and adds to protection by reducing genomic instability and the number of mutated cells in tissues. At low doses, damage reduction by adaptive protection against damage from endogenous sources predictably outweighs radiogenic damage induction. The analysis of the consequences of the particular low-dose scenario shows that the linear-no-threshold (LNT) hypothesis for cancer risk is scientifically unfounded and appears to be invalid in favor of a threshold or hormesis. This is consistent with data both from animal studies and human epidemiological observations on low-dose induced cancer. The LNT hypothesis should be abandoned and be replaced by a hypothesis that is scientifically justified. The appropriate model should include terms for both linear and non-linear response probabilities. Maintaining the LNT-hypothesis as basis for radiation protection causes unressonable fear and expenses. (author)

  2. What are check dams made for? An historical perspective from the French experience

    Science.gov (United States)

    Piton, Guillaume; Carladous, Simon; Recking, Alain

    2015-04-01

    technical and sociological reasons. The Mountain lands' conservation and restoration law of 1882 aimed to better fit local issues. The idea of the presentation is thus to highlight how evolved the historical comprehension of torrential hazards and of the usefulness of check dams in mitigation plans in a changing environment on the technical as well as on the sociological and regulatory points of view. Pioneering scientific and technical works on torrential hydraulics and check dams will be presented. Describing the global context that leads to French laws of 1860,1864 and 1882 will allow us to explain the extensive development of the works in more than a thousand of torrents and a hundred of big landslides. We then will discuss the evolution of technics during the beginning of the 20th century and the changes induced after WWII by the arrival of reinforced-concrete technics. We will conclude the presentation with a synthesis table aiming to highlight the different functions of check dams based on a description of their situations in the watershed, compare to other structures' situations and on shape criteria. This historical perspective will hopefully help people to better understand for which purposes some structures have been built in the past centuries and what lessons can be learnt from this assessment.

  3. Poseidon's paintbox : historical archives of ocean colour in global-change perspective

    Science.gov (United States)

    Wernand, M. R.

    2011-11-01

    In the thesis introduction issues are discussed on the historical background of marine optics and on marine optical devices that were used over the past centuries to observe and measure; as in all sciences, in marine optics we can see a steady development: that of ‘measuring’, beginning many centuries ago, to 'knowing' and since less than a century to the understanding of the phenomenon. Hereafter, six themes are treated successively. The first theme, ‘Ocean optics from 1600 (Hudson) to 1930 (Raman), shift in interpretation of natural water colouring’, addresses the question of why it took so long a time to explain the phenomenon ‘the colouring of the sea’, especially the blue colour, despite the age-long interest of sailors, for practical purposes of navigation and detection of fish - of which more later. The second theme ‘On the history of the Secchi disc’, describes the search to establish methods for the determination of (sea) water clarity concerning purposes of navigation (near coast colour changes) just mentioned to detect shoals, and for a more basic purpose, tracing lost objects. The search to determine the clarity of lakes and seas culminated in the invention of the Secchi disc, used since the late 19th century. The third theme, ‘Spectral analysis of the Forel-Ule ocean colour comparator scale’, addresses the accuracy of a colour scale proposed, used in limnology and oceanography. Scale observations are put into perspective with contemporary measurements on the colour of the sea. The fourth theme, ‘Ocean colour changes in the North Pacific since 1930’, handles the question whether long-term ocean colour changes using historic Forel-Ule observations, in this part of the ocean made very frequently over time, can be determined in relation to global change. In principal global warming may cause a gradual change in ocean colour due to the effect of biological, chemical and physical aspects of the ocean-surface. The fifth theme,

  4. Choice of rotatable plug seals for prototype fast breeder reactor: Review of historical perspectives

    Energy Technology Data Exchange (ETDEWEB)

    Sinha, N.K., E-mail: nksinha@igcar.gov.in; Raj, Baldev, E-mail: baldev.dr@gmail.com

    2015-09-15

    Highlights: • Choice and arrangement of elastomeric inflatable and backup seals as primary and secondary barriers. • With survey (mid-1930s onwards) of reactor, sealing, R&D and rubber technology. • Load, reliability, safety, life and economy of seals and reactors are key factors. • PFBR blends concepts and experience of MOX fuelled FBRs with original solutions. • R&D indicates inflatable seal advanced fluoroelastomer pivotal in unifying nuclear sealing. - Abstract: Choice and arrangement of elastomeric primary inflatable and secondary backup seals for the rotatable plugs (RPs) of 500 MW (e), sodium cooled, pool type, 2-loop, mixed oxide (MOX) fuelled Prototype Fast Breeder Reactor (PFBR) is depicted with review of various historical perspectives. Static and dynamic operation, largest diameters (PFBR: ∼6.4 m, ∼4.2 m), widest gaps and variations (5 ± 2 mm) and demanding operating requirements make RP openings on top shield (TS) the most difficult to seal which necessitated extensive development from 1950s to early 1990s. Liquid metal freeze seals with life equivalent to reactor prevailed as primary barrier (France, Japan, U.S.S.R.) during pre-1980s in spite of bulk, cost and complexity due to the abilities to meet zero leakage and resist core disruptive accident (CDA). Redefinition of CDA as beyond design basis accident, tolerable leakage and enhanced economisation drive during post-1980s established elastomeric inflatable seal as primary barrier excepting in U.S.S.R. (MOX fuel, freeze seal) and U.S.A. (metallic fuel). Choice of inflatable seal for PFBR RPs considers these perspectives, inherent advantages of elastomers and those of inflatable seals which maximise seal life. Choice of elastomeric backup seal as secondary barrier was governed by reliability and minimisation as well as distribution of load (temperature, radiation, mist) to maximise seal life. The compact sealing combination brings the hanging RPs at about the same elevation to reduce

  5. History from Children's Perspectives: Learning to Read and Write Historical Accounts Using Family Sources

    Science.gov (United States)

    Schmidt, Maria Auxiliadora; Garcia, Tania Maria F. Braga

    2010-01-01

    This paper presents the results of an investigation which was part of a project called "Recreating Histories". It is concerned with the analysis of historical narratives created by the children who participated in the project and an analysis of historical sources kept by families who live in Campina Grande do Sul (Brazil). It draws on…

  6. Historical Facts and Fictions: Representing and Reading Diverse Perspectives on the Past.

    Science.gov (United States)

    Enciso, Patricia E.; Jenkins, Christine; Rogers, Theresa; Tyson, Cynthia; Marshall, Elizabeth; Robinson, Dwan; Wissman, Jackie; Price-Dennis, Detra; Core, Elizabeth; Morss, Betty; Cordova, Carmen; Youngsteadt-Parish, Denise

    2000-01-01

    Presents brief descriptions of 22 recently published books for children and adolescents that present untold stories that begin to fill in the gaps of mainstream versions of the past. Includes categories of historical fiction, historical nonfiction, biography/memoir, and poetry and verse. Discusses these books in tandem with numerous landmark…

  7. The Inside, Out: Diaries as Entry Points to Historical Perspective-Taking

    Science.gov (United States)

    Lemisko, Lynn

    2010-01-01

    Diaries can serve as meaningful entry points for advancing historical consciousness and develop historical thinking (Seixas, 2002) because they can connect readers/learners with the diverse emotions, thoughts and motivations of the people who wrote them in particular times and particular places. According to philosopher and historian, R.G.…

  8. Hormesis on life-history traits: is there such thing as a free lunch?

    NARCIS (Netherlands)

    Jager, T.; Barsi, A.; Ducrot, V.

    2013-01-01

    The term "hormesis" is used to describe dose-response relationships where the response is reversed between low and high doses of a stressor (generally, stimulation at low doses and inhibition at high ones). A mechanistic explanation is needed to interpret the relevance of such responses, but there

  9. Model Uncertainty via the Integration of Hormesis and LNT as the Default in Cancer Risk Assessment.

    Science.gov (United States)

    Calabrese, Edward J

    2015-01-01

    On June 23, 2015, the US Nuclear Regulatory Commission (NRC) issued a formal notice in the Federal Register that it would consider whether "it should amend its 'Standards for Protection Against Radiation' regulations from the linear non-threshold (LNT) model of radiation protection to the hormesis model." The present commentary supports this recommendation based on the (1) flawed and deceptive history of the adoption of LNT by the US National Academy of Sciences (NAS) in 1956; (2) the documented capacity of hormesis to make more accurate predictions of biological responses for diverse biological end points in the low-dose zone; (3) the occurrence of extensive hormetic data from the peer-reviewed biomedical literature that revealed hormetic responses are highly generalizable, being independent of biological model, end point measured, inducing agent, level of biological organization, and mechanism; and (4) the integration of hormesis and LNT models via a model uncertainty methodology that optimizes public health responses at 10(-4). Thus, both LNT and hormesis can be integratively used for risk assessment purposes, and this integration defines the so-called "regulatory sweet spot."

  10. Radiation hormesis. Stimulatory effects of low level ionizing radiation on plant

    Energy Technology Data Exchange (ETDEWEB)

    Kinoshita, Shigenobu; Masui, Hisashi; Yoshida, Shigeo; Murata, Isao [Osaka Univ., Suita (Japan). Faculty of Engineering

    1999-04-01

    Recently, the study for radiation hormesis has been executed against animals and plants; subharmful doses of radiation may evoke a stimulatory response in any organism. We executed irradiating experiments of dry seeds with fusion (D-T) neutron, fission neutron, cobalt-60 gamma-ray and investigated existence of the radiation hormesis effects by measuring germination, the length of a stalk and the total weight of a seed leaf on the 7th day after starting cultivation. And we estimated radiation hormesis effects by relative effectiveness, the ratio of the mean value of measurement subjects for the irradiated group to that of non-irradiated group. In relation to Raphanus sativus, the hormesis effects on seed leaf growth from irradiated seeds have only turned up in seed groups irradiated by the fusion (D-T) neutron. We have confirmed that absorbed dose range which revealed the effects is from 1 cGy to 10 Gy and the increasing rate is from 5 percent to 25 percent against a control group. (author)

  11. The territoriality of spatial-economic governance in historical perspective: the case of the Netherlands

    NARCIS (Netherlands)

    Lagendijk, A.; Boekema, F.W.M.; Arts, B.J.M.; Lagendijk, A.; Houtum, H.J. van

    2009-01-01

    This chapter explores how shifts in governmentality and the rise of new forms of governance in the field of regional innovation policies have impacted upon perspectives on territoriality and practices of territorialisation. The debate centres on two dominant perspectives, both endorsed by

  12. A Historical Perspective of Global Warming Potential from Municipal Solid Waste Management

    DEFF Research Database (Denmark)

    Habib, Komal; Schmidt, Jannick Højrup; Christensen, Per

    2013-01-01

    The Municipal Solid Waste Management (MSWM) sector has developed considerably during the past century, paving the way for maximum resource (materials and energy) recovery and minimising environmental impacts such as global warming associated with it. The current study is assessing the historical...... development of MSWM in the municipality of Aalborg, Denmark throughout the period of 1970 to 2010, and its implications regarding Global Warming Potential (GWP100), using the Life Cycle Assessment (LCA) approach. Historical data regarding MSW composition, and different treatment technologies...

  13. [The proof of paternity. An andrological-forensic challenge in historical perspective].

    Science.gov (United States)

    Albrecht, K; Schultheiss, D

    2004-10-01

    For centuries, difficulties have occurred in determining unresolved paternities. In addition to the modern standard methods, such as the examination of DNA or serological proof, expert opinion on fertility once played an important role. The andrological difference between incapability to fertilise and the inability to participate in sexual intercourse was also distinguished historically. Of special significance was the discovery of spermatozoa by the medical student Johan Ham in 1677 and their further investigation by Antoni van Leeuwenhoek.Recently, modern DNA methods have also been applied for historical investigations. Illustrious examples are the DNA analysis in the case of Kaspar Hauser of Ansbach and the dispute about Thomas Jefferson, President of the U.S., fathering a child by one of his slaves. In this discourse, a medicinal-forensic review of the development of expert opinion, illustrated with historical case studies, is given.

  14. Translating Bourdieu: cultural capital and the English middle class in historical perspective.

    Science.gov (United States)

    Gunn, Simon

    2005-03-01

    This article examines the ways in which Pierre Bourdieu's work on culture and cultural capital can be applied to the study of the English middle class in the nineteenth and twentieth centuries. Drawing on a wide historical literature, the article argues for the significance of culture as a constitutive element of middle-class identities in England since 1800. It goes on to examine Bourdieu's ideas of 'objectivated', 'instutionalized' and 'incorporated' cultural capital, in the context of family, inheritance, education and the body. The article identifies changes in the historical forms which cultural capital has taken and emphasizes the importance of analysing family processes of intergenerational transmission.

  15. The real dope: social, legal, and historical perspectives on the regulation of drugs in Canada

    National Research Council Canada - National Science Library

    Montigny, Edgar-André

    2011-01-01

    ... - to examine the relationship between moral judgment and legal regulation. Highlights of this collection include rare glimpses into how LSD, cocaine, and Ecstasy have historically been treated by authority figures. Other topics explored range from anti-smoking campaigns and addiction treatment to the relationship between ethnicity and liquor control. Readers ...

  16. Exploring Perspectives of Transitional Leadership Styles at Historically Black Colleges and Universities: A Case Study

    Science.gov (United States)

    Mosley, Melvin L.

    2017-01-01

    Historically Black Colleges and Universities (HBCUs) continue to strive for academic relevance in spite of the national problem of the misalignment of mission and values among their institutional leadership. The national problem was important to both the HBCU institutions and the entire academic community to establish global relevancy. The…

  17. Practicality in Curriculum Building: A Historical Perspective on the Mission of Chinese Education

    Science.gov (United States)

    Bai, Limin

    2013-01-01

    This paper examines how the definition and interpretation of the concept gewu zhizhi ???? (investigating things and extending knowledge), evolved along with Chinese intellectual efforts to construct the framework for Chinese learning which, in turn, had a profound impact on the development of educational curricula in different historical periods.…

  18. Hebrew Education in the United States: Historical Perspectives and Future Directions

    Science.gov (United States)

    Avni, Sharon

    2014-01-01

    This article sketches the trajectory of Hebrew education in the United States from the early 1900s to the present. Attending to the historiography of Hebrew education, it shows how current curricula and pedagogical approaches have been stamped by historical considerations and language ideologies, how goals and strategies have changed (or remained…

  19. Research in the Work of New Zealand Teacher Educators: A Cultural-Historical Activity Theory Perspective

    Science.gov (United States)

    Berg, David A. G.; Gunn, Alexandra C.; Hill, Mary F.; Haigh, Mavis

    2016-01-01

    In this article we use cultural-historical activity theory to explore the place of research in the work of New Zealand university-based teacher educators (TEs). We consider how aspirations for a research-informed initial teacher education are served by New Zealand universities' recruitment practices and TEs' actual work. We suggest that TEs value…

  20. Student Motivation for Involvement in Supervised Agricultural Experiences: An Historical Perspective

    Science.gov (United States)

    Bird, William A.; Martin, Michael J.; Simonsen, Jon C.

    2013-01-01

    The purpose of this study was to examine student motivation for SAEs through the lens of the Self-Determination Theory. Self-Determination Theory proposed that human beings are more genuinely motivated when driven by internal factors as opposed to external factors. We used historical research and general qualitative interpretative methods to…

  1. A conceptual perspective for investigating motive in cultural-historical theory

    DEFF Research Database (Denmark)

    Chaiklin, Seth

    2012-01-01

    This chapter provides a brief discussion of the other chapters in this edited volume, and then presents a brief introduction to the concept of motive within cultural-historical theory. This discussion includes a discussion of why the concept is needed, the ontological shift in the explanatory log...

  2. Government's Paper Empire: Historical Perspectives on Measuring Student Achievement in British Columbia Schools, 1872-1999

    Science.gov (United States)

    Fleming, Thomas; Raptis, Helen

    2005-01-01

    Few historical studies of government's interest in student achievement exist and, of those that do, most concern themselves with relatively short periods of time, a decade or two in general. This discussion takes a longer view of measurement practices in one jurisdiction, British Columbia. Based on archival records, it examines testing and…

  3. "To Kill a Mockingbird": An Historical Perspective. Learning Page Lesson Plan.

    Science.gov (United States)

    Prody, Kathleen; Whearty, Nicolet

    Students gain from a sense of the living history that surrounds Harper Lee's novel, "To Kill a Mockingbird." Through studying primary source materials from American Memory and other online sources, students of all backgrounds may better grasp how historical events and human forces have shaped relationships between black and white and…

  4. Health and Fitness Courses in Higher Education: A Historical Perspective and Contemporary Approach

    Science.gov (United States)

    Bjerke, Wendy

    2013-01-01

    The prevalence of obesity among 18- to 24-year-olds has steadily increased. Given that the majority of young American adults are enrolled in colleges and universities, the higher education setting could be an appropriate environment for health promotion programs. Historically, health and fitness in higher education have been provided via…

  5. Perspective has a strong effect on the calculation of historical contributions to global warming

    Science.gov (United States)

    Skeie, Ragnhild B.; Fuglestvedt, Jan; Berntsen, Terje; Peters, Glen P.; Andrew, Robbie; Allen, Myles; Kallbekken, Steffen

    2017-02-01

    The politically contentious issue of calculating countries’ contributions to climate change is strongly dependent on methodological choices. Different principles can be applied for distributing efforts for reducing human-induced global warming. According to the ‘Brazilian Proposal’, industrialized countries would reduce emissions proportional to their historical contributions to warming. This proposal was based on the assumption that the political process would lead to a global top-down agreement. The Paris Agreement changed the role of historical responsibilities. Whereas the agreement refers to equity principles, differentiation of mitigation efforts is delegated to each country, as countries will submit new national contributions every five years without any international negotiation. It is likely that considerations of historical contributions and distributive fairness will continue to play a key role, but increasingly so in a national setting. Contributions to warming can be used as a background for negotiations to inform and justify positions, and may also be useful for countries’ own assessment of what constitutes reasonable and fair contributions to limiting warming. Despite the fact that the decision from COP21 explicitly rules out compensation in the context of loss and damage, it is likely that considerations of historical responsibility will also play a role in future discussions. However, methodological choices have substantial impacts on calculated contributions to warming, including rank-ordering of contributions, and thus support the view that there is no single correct answer to the question of how much each country has contributed. There are fundamental value-related and ethical questions that cannot be answered through a single set of calculated contributions. Thus, analyses of historical contributions should not present just one set of results, but rather present a spectrum of results showing how the calculated contributions vary with a

  6. Intrinsic electrical properties of mammalian neurons and CNS function: a historical perspective

    Science.gov (United States)

    Llinás, Rodolfo R.

    2014-01-01

    This brief review summarizes work done in mammalian neuroscience concerning the intrinsic electrophysiological properties of four neuronal types; Cerebellar Purkinje cells, inferior olivary cells, thalamic cells, and some cortical interneurons. It is a personal perspective addressing an interesting time in neuroscience when the reflex view of brain function, as the paradigm to understand global neuroscience, began to be modified toward one in which sensory input modulates rather than dictates brain function. The perspective of the paper is not a comprehensive description of the intrinsic electrical properties of all nerve cells but rather addresses a set of cell types that provide indicative examples of mechanisms that modulate brain function. PMID:25408634

  7. INTRINSIC ELECTRICAL PROPERTIES OF MAMMALIAN NEURONS AND CNS FUNCTION: A HISTORICAL PERSPECTIVE

    Directory of Open Access Journals (Sweden)

    Rodolfo R Llinas

    2014-11-01

    Full Text Available This brief review summarizes work done in mammalian neuroscience concerning the intrinsic electrophysiological properties of four neuronal types; Cerebellar Purkinje cells, inferior olivary cells, thalamic cells, and some cortical interneurons. It is a personal perspective addressing an interesting time in neuroscience when the reflex view of brain function, as the paradigm to understand global neuroscience, began to be modified towards one in which sensory input modulates rather than dictates brain function. The perspective of the paper is not a comprehensive description of the intrinsic electrical properties of all nerve cells but rather addresses a set of cell types that provide indicative examples of mechanisms that modulate brain function.

  8. The rare earth element (REE) lanthanum (La) induces hormesis in plants.

    Science.gov (United States)

    Agathokleous, Evgenios; Kitao, Mitsutoshi; Calabrese, Edward J

    2018-07-01

    Lanthanum is a rare earth element (REE) which has been extensively studied due to its wide application in numerous fields with a potential accumulation in the environment. It has long been known for its potential to stimulate plant growth within a hormetic-biphasic dose response framework. This article provides evidence from a series of high resolution studies published within the last two decades demonstrating a substantial and significant occurrence of lanthanum-induced hormesis in plants. These findings suggest that hormetic responses should be built into the study design of hazard assessment study protocols and included in the risk assessment process. Hormesis also offers the opportunity to substantially improve cost benefit estimates for environmental contaminants, which have the potential to induce beneficial/desirable effects at low doses. Copyright © 2018 Elsevier Ltd. All rights reserved.

  9. Water, mining, and waste: An historical and economic perspective on conflict management in South Africa

    OpenAIRE

    Rebecca A. Adler; Marius Claassen; Linda Godfrey; Anthony R. Turton.

    2007-01-01

    Lack of government intervention in South Africa’s mining industry has worsened conflicts associated with limited water resources. With the advent of democracy, new legislation demands that all South African citizens have the right to a clean, safe environment, including access to potable water, and that the country develop in a sustainable manner. But conflict remains due to the historical partnership between the government and the mining industry, as well as due to cumulative impacts associa...

  10. Historical films and the Asian nations: struggles for independence and emancipation – a gendered perspective

    OpenAIRE

    Wan Yahaya, Wan Aida

    2017-01-01

    This thesis explores in detail fourteen historical films about Asian nations, most made by indigenous production companies and directors from the countries depicted in the films. The thesis has concentrated on films from Southeast Asia, but includes extensive discussion of two films made about Indian history and of two films made about Japanese history. The thesis concentrates on films concerned with issues of national independence, the period of the formation of the nation, and with women’s ...

  11. Historical perspectives and future directions in the surgical management of retroperitoneal sarcoma.

    Science.gov (United States)

    Tseng, William W; Seo, Hyun Jae; Pollock, Raphael E; Gronchi, Alessandro

    2018-01-01

    Retroperitoneal sarcomas (RPS) have fascinated and intrigued physicians both past and present. Operative mortality rates were historically very high and complete resection was not possible for the majority of patients until only the last 2 decades. More recently, changes to the surgical approach and clinical decision-making in RPS have improved patient outcomes. With select integration of nonsurgical therapies, continued RPS-specific research, and ongoing collaborative efforts among major referral centers, the future appears promising. © 2017 Wiley Periodicals, Inc.

  12. Historical Perspectives of Federal Educational Promises and Performance Among the Fort Berthold Indians.

    Science.gov (United States)

    Stockman, Wallace Henry

    The study concerns Federal Indian Law--its social origins, its historical growth and direction, and its effectiveness among the 3 affiliated tribes (Mandan, Hidatsa, and Arikara) of the Ft. Berthold American Indian Reservation (population total 2,750, with a birth rate of 40 per 1,000 and a death rate of 9 per 1,000) located in North Dakota. It is…

  13. The Historical Perspective of Formation of Offshore Jurisdictions as the Global System of Tax Evasion

    OpenAIRE

    Synyutka Nataliya G.; Synyutka Oleg M.

    2017-01-01

    The aim of this publication is improving the knowledge about the genesis of formation of offshore jurisdictions. The article characterizes the historical stages of origination of tax havens on the basis of theoretical generalizations and comparing the results of studies and publications on the specified issues. The article identifies the main groups of tax havens: offshores of the colonies of the former British Empire; the European havens; the group of simulators (such as Panama, Uruguay, Dub...

  14. SRS SLUDGE BATCH QUALIFICATION AND PROCESSING; HISTORICAL PERSPECTIVE AND LESSONS LEARNED

    Energy Technology Data Exchange (ETDEWEB)

    Cercy, M.; Peeler, D.; Stone, M.

    2013-09-25

    This report provides a historical overview and lessons learned associated with the SRS sludge batch (SB) qualification and processing programs. The report covers the framework of the requirements for waste form acceptance, the DWPF Glass Product Control Program (GPCP), waste feed acceptance, examples of how the program complies with the specifications, an overview of the Startup Program, and a summary of continuous improvements and lessons learned. The report includes a bibliography of previous reports and briefings on the topic.

  15. China’s Land-Use Changes during the Past 300 Years: A Historical Perspective

    Directory of Open Access Journals (Sweden)

    Lijuan Miao

    2016-08-01

    Full Text Available Understanding the processes of historical land-use change is crucial to the research of global environmental sustainability. Here we examine and attempt to disentangle the evolutionary interactions between land-use change and its underlying causes through a historical lens. We compiled and synthesized historical land-use change and various biophysical, political, socioeconomic, and technical datasets, from the Qing dynasty to modern China. The analysis reveals a clear transition period between the 1950s and the 1980s. Before the 1950s, cropland expanded while forested land diminished, which was also accompanied by increasing population; after the 1980s land-use change exhibited new characteristics: changes in cropland, and decoupling of forest from population as a result of agricultural intensification and globalization. Chinese political policies also played an important and complex role, especially during the 1950s–1980s transition periods. Overall, climate change plays an indirect but fundamental role in the dynamics of land use via a series of various cascading effects such as shrinking agricultural production proceeding to population collapse and outbreaks of war. The expected continuation of agricultural intensification this century should be able to support increasing domestic demand for richer diets, but may not be compatible with long-term environmental sustainability.

  16. Historical and future perspectives of global soil carbon response to climate and land-use changes

    Science.gov (United States)

    Eglin, T.; Ciais, P.; Piao, S. L.; Barre, P.; Bellassen, V.; Cadule, P.; Chenu, C.; Gasser, T.; Koven, C.; Reichstein, M.; Smith, P.

    2010-11-01

    ABSTRACT In this paper, we attempt to analyse the respective influences of land-use and climate changes on the global and regional balances of soil organic carbon (SOC) stocks. Two time periods are analysed: the historical period 1901-2000 and the period 2000-2100. The historical period is analysed using a synthesis of published data as well as new global and regional model simulations, and the future is analysed using models only. Historical land cover changes have resulted globally in SOC release into the atmosphere. This human induced SOC decrease was nearly balanced by the net SOC increase due to higher CO2 and rainfall. Mechanization of agriculture after the 1950s has accelerated SOC losses in croplands, whereas development of carbon-sequestering practices over the past decades may have limited SOC loss from arable soils. In some regions (Europe, China and USA), croplands are currently estimated to be either a small C sink or a small source, but not a large source of CO2 to the atmosphere. In the future, according to terrestrial biosphere and climate models projections, both climate and land cover changes might cause a net SOC loss, particularly in tropical regions. The timing, magnitude, and regional distribution of future SOC changes are all highly uncertain. Reducing this uncertainty requires improving future anthropogenic CO2 emissions and land-use scenarios and better understanding of biogeochemical processes that control SOC turnover, for both managed and un-managed ecosystems.

  17. China’s Land-Use Changes during the Past 300 Years: A Historical Perspective

    Science.gov (United States)

    Miao, Lijuan; Zhu, Feng; Sun, Zhanli; Moore, John C.; Cui, Xuefeng

    2016-01-01

    Understanding the processes of historical land-use change is crucial to the research of global environmental sustainability. Here we examine and attempt to disentangle the evolutionary interactions between land-use change and its underlying causes through a historical lens. We compiled and synthesized historical land-use change and various biophysical, political, socioeconomic, and technical datasets, from the Qing dynasty to modern China. The analysis reveals a clear transition period between the 1950s and the 1980s. Before the 1950s, cropland expanded while forested land diminished, which was also accompanied by increasing population; after the 1980s land-use change exhibited new characteristics: changes in cropland, and decoupling of forest from population as a result of agricultural intensification and globalization. Chinese political policies also played an important and complex role, especially during the 1950s–1980s transition periods. Overall, climate change plays an indirect but fundamental role in the dynamics of land use via a series of various cascading effects such as shrinking agricultural production proceeding to population collapse and outbreaks of war. The expected continuation of agricultural intensification this century should be able to support increasing domestic demand for richer diets, but may not be compatible with long-term environmental sustainability. PMID:27571087

  18. Nutrient removal by Chlorella vulgaris F1068 under cetyltrimethyl ammonium bromide induced hormesis.

    Science.gov (United States)

    Zhou, Qiongzhi; Li, Feng; Ge, Fei; Liu, Na; Kuang, Yangduo

    2016-10-01

    Toxicants are generally harmful to biotechnology in wastewater treatment. However, trace toxicant can induce microbial hormesis, but to date, it is still unknown how this phenomenon affects nutrient removal during municipal wastewater treatment process. Therefore, this study focused on the effects of hormesis induced by cetyltrimethyl ammonium bromide (CTAB), a representative quaternary ammonium cationic surfactant, on nutrient removal by Chlorella vulgaris F1068. Results showed that when the concentration of CTAB was less than 10 ng/L, the cellular components chlorophyll a, proteins, polysaccharides, and total lipids increased by 10.11, 58.17, 38.78, and 11.87 %, respectively, and some enzymes in nutrient metabolism of algal cells, such as glutamine synthetase (GS), acid phosphatase (ACP), H(+)-ATPase, and esterase, were also enhanced. As a result, the removal efficiencies of ammonia nitrogen (NH4 (+)) and total phosphorus (TP) increased by 14.66 and 8.51 %, respectively, compared to the control during a 7-day test period. The underlying mechanism was mainly due to an enhanced photosynthetic activity of C. vulgaris F1068 indicated by the increase in chlorophyll fluorescence parameters (the value of Fv/Fm, ΦII, Fv/Fo, and rETR increased by 12.99, 7.56, 25.59, and 8.11 %, respectively) and adenylate energy charge (AEC) (from 0.68 to 0.72). These results suggest that hormesis induced by trace toxicants could enhance the nutrient removal, which would be further considered in the design of municipal wastewater treatment processes. Graphical abstract The schematic mechanism of C. vulgaris F1068 under CTAB induced hormesis. Green arrows ( ) represent the increase and the red arrow ( ) represents the decrease.

  19. Hormesis on life-history traits: is there such thing as a free lunch?

    Science.gov (United States)

    Jager, Tjalling; Barsi, Alpar; Ducrot, Virginie

    2013-03-01

    The term "hormesis" is used to describe dose-response relationships where the response is reversed between low and high doses of a stressor (generally, stimulation at low doses and inhibition at high ones). A mechanistic explanation is needed to interpret the relevance of such responses, but there does not appear to be a single universal mechanism underlying hormesis. When the endpoint is a life-history trait such as growth or reproduction, a stimulation of the response comes with costs in terms of resources. Organisms have to obey the conservation laws for mass and energy; there is no such thing as a free lunch. Based on the principles of Dynamic Energy Budget theory, we introduce three categories of explanations for hormesis that obey the conservation laws: acquisition (i.e., increasing the input of energy into the individual), allocation (i.e., rearranging the energy flows over various traits) and medication (e.g., the stressor is an essential element or acts as a cure for a disease or infection). In this discussion paper, we illustrate these explanations with cases where they might apply, and elaborate on the potential consequences for field populations.

  20. Intrinsic electrical properties of mammalian neurons and CNS function: a historical perspective

    OpenAIRE

    Llinás, Rodolfo R.

    2014-01-01

    This brief review summarizes work done in mammalian neuroscience concerning the intrinsic electrophysiological properties of four neuronal types; Cerebellar Purkinje cells, inferior olivary cells, thalamic cells, and some cortical interneurons. It is a personal perspective addressing an interesting time in neuroscience when the reflex view of brain function, as the paradigm to understand global neuroscience, began to be modified towards one in which sensory input modulates rather than dictate...

  1. Solar System Exploration Augmented by Lunar and Outer Planet Resource Utilization: Historical Perspectives and Future Possibilities

    Science.gov (United States)

    Palaszewski, Bryan

    2014-01-01

    Establishing a lunar presence and creating an industrial capability on the Moon may lead to important new discoveries for all of human kind. Historical studies of lunar exploration, in-situ resource utilization (ISRU) and industrialization all point to the vast resources on the Moon and its links to future human and robotic exploration. In the historical work, a broad range of technological innovations are described and analyzed. These studies depict program planning for future human missions throughout the solar system, lunar launched nuclear rockets, and future human settlements on the Moon, respectively. Updated analyses based on the visions presented are presented. While advanced propulsion systems were proposed in these historical studies, further investigation of nuclear options using high power nuclear thermal propulsion, nuclear surface power, as well as advanced chemical propulsion can significantly enhance these scenarios. Robotic and human outer planet exploration options are described in many detailed and extensive studies. Nuclear propulsion options for fast trips to the outer planets are discussed. To refuel such vehicles, atmospheric mining in the outer solar system has also been investigated as a means of fuel production for high energy propulsion and power. Fusion fuels such as helium 3 (3He) and hydrogen (H2) can be wrested from the atmospheres of Uranus and Neptune and either returned to Earth or used in-situ for energy production. Helium 3 and H2 (deuterium, etc.) were the primary gases of interest with hydrogen being the primary propellant for nuclear thermal solid core and gas core rocket-based atmospheric flight. A series of analyses have investigated resource capturing aspects of atmospheric mining in the outer solar system. These analyses included the gas capturing rate, storage options, and different methods of direct use of the captured gases. While capturing 3He, large amounts of hydrogen and 4He are produced. With these two additional

  2. Fish and fisheries in the Lower Rhine 1550-1950: A historical-ecological perspective.

    Science.gov (United States)

    Lenders, H J Rob

    2017-11-01

    Regulation and intensive use of most of the world's large rivers, has led to dramatic decline and even to extinction of riverine fish populations like salmon and sturgeon in the river Rhine. In general this decline is considered an unwelcome side-effect of the Industrial Revolution and large-scale river regulation (c. 1800), but the deterioration of stocks of some species may have started well before the 19th century. For the river Rhine, data on fish landings as proxies of abundance in the period 1550-1950 can be derived from historical market prices, fisheries taxation and fishery and fish auctions statistics, especially for commercially interesting species like Atlantic salmon, sturgeon, Allis shad and Twaite shad. Most data from which abundance of these species can be derived, however, appear to be missing in historical sources until decline of the investigated species sets in and the species become economically scarce goods. Atlantic salmon in the Rhine catchment appears to be already in decline during Early Modern Times (post 1500 AD) after which time river regulation, pollution and intensified fisheries finished off the remaining stocks in the 20th century. Salmon decline caused a cascade in the River Rhine ecosystem as fisheries shifted to, especially, Allis shad and Twaite shad, followed by (near-)extinction of these species. Dropping yields of salmon fishery did not lead to increased sturgeon fishery, although numbers of sturgeon also dwindled to extinction in the river Rhine. The onset of sturgeon decline appears to coincide with the period of the first large regulation works. It is shown that historical-ecological data on fish abundance can quantitatively underpin detrimental long-term processes in river ecosystems. Copyright © 2016 Elsevier Ltd. All rights reserved.

  3. Italian Chemists’ Contributions to Named Reactions in Organic Synthesis: An Historical Perspective

    Directory of Open Access Journals (Sweden)

    Gianluca Papeo

    2013-09-01

    Full Text Available From the second half of the 19th century up to modern times, the tremendous contribution of Italian chemists to the development of science resulted in the discovery of a number of innovative chemical transformations. These reactions were subsequently christened according to their inventors’ name and so entered into the organic chemistry portfolio of “named organic reactions”. As these discoveries were being conceived, massive social, political and geographical changes in these chemists’ homeland were also occurring. In this review, a brief survey of known (and some lesser known named organic reactions discovered by Italian chemists, along with their historical contextualization, is presented.

  4. Italian chemists' contributions to named reactions in organic synthesis: an historical perspective.

    Science.gov (United States)

    Papeo, Gianluca; Pulici, Maurizio

    2013-09-04

    From the second half of the 19th century up to modern times, the tremendous contribution of Italian chemists to the development of science resulted in the discovery of a number of innovative chemical transformations. These reactions were subsequently christened according to their inventors' name and so entered into the organic chemistry portfolio of "named organic reactions". As these discoveries were being conceived, massive social, political and geographical changes in these chemists' homeland were also occurring. In this review, a brief survey of known (and some lesser known) named organic reactions discovered by Italian chemists, along with their historical contextualization, is presented.

  5. Women in physics in El Salvador: Historical perspectives and current challenges

    Science.gov (United States)

    Jiménez, Telma; Jiménez, Diana; Larios, Gloria

    2015-12-01

    Physics as a discipline in El Salvador's higher education system has struggled historically; however, since 1991, it has enjoyed a growth-friendly environment. While there are few female physicists in El Salvador, they are employed in various organizations and educational institutions, demonstrating that physics is a viable career path. El Salvador currently offers a range of opportunities for women in physics. With the support of the 5th IUPAP International Conference on Women in Physics, we will both meet the challenges and take advantage of the opportunities that face female physicists in El Salvador.

  6. Can artificial parthenogenesis sidestep ethical pitfalls in human therapeutic cloning? An historical perspective

    Science.gov (United States)

    Fangerau, H

    2005-01-01

    The aim of regenerative medicine is to reconstruct tissue that has been lost or pathologically altered. Therapeutic cloning seems to offer a method of achieving this aim; however, the ethical debate surrounding human therapeutic cloning is highly controversial. Artificial parthenogenesis—obtaining embryos from unfertilised eggs—seems to offer a way to sidestep these ethical pitfalls. Jacques Loeb (1859–1924), the founding father of artificial parthogenesis, faced negative public opinion when he published his research in 1899. His research, the public's response to his findings, and his ethical foundations serve as an historical argument both for the communication of science and compromise in biological research. PMID:16319240

  7. Historical and current introgression in a Mesoamerican hummingbird species complex: a biogeographic perspective

    Directory of Open Access Journals (Sweden)

    Rosa Alicia Jiménez

    2016-01-01

    Full Text Available The influence of geologic and Pleistocene glacial cycles might result in morphological and genetic complex scenarios in the biota of the Mesoamerican region. We tested whether berylline, blue-tailed and steely-blue hummingbirds, Amazilia beryllina, Amazilia cyanura and Amazilia saucerottei, show evidence of historical or current introgression as their plumage colour variation might suggest. We also analysed the role of past and present climatic events in promoting genetic introgression and species diversification. We collected mitochondrial DNA (mtDNA sequence data and microsatellite loci scores for populations throughout the range of the three Amazilia species, as well as morphological and ecological data. Haplotype network, Bayesian phylogenetic and divergence time inference, historical demography, palaeodistribution modelling, and niche divergence tests were used to reconstruct the evolutionary history of this Amazilia species complex. An isolation-with-migration coalescent model and Bayesian assignment analysis were assessed to determine historical introgression and current genetic admixture. mtDNA haplotypes were geographically unstructured, with haplotypes from disparate areas interdispersed on a shallow tree and an unresolved haplotype network. Assignment analysis of the nuclear genome (nuDNA supported three genetic groups with signs of genetic admixture, corresponding to: (1 A. beryllina populations located west of the Isthmus of Tehuantepec; (2 A. cyanura populations between the Isthmus of Tehuantepec and the Nicaraguan Depression (Nuclear Central America; and (3 A. saucerottei populations southeast of the Nicaraguan Depression. Gene flow and divergence time estimates, and demographic and palaeodistribution patterns suggest an evolutionary history of introgression mediated by Quaternary climatic fluctuations. High levels of gene flow were indicated by mtDNA and asymmetrical isolation-with-migration, whereas the microsatellite analyses

  8. The Regulation of Market Manipulation in Australia: A Historical Comparative Perspective

    Directory of Open Access Journals (Sweden)

    Howard Chitimira

    2015-07-01

    Full Text Available Notably, in Australia, market abuse practices like market manipulation and other market misconduct practices are expressly prohibited under the Corporations Act as amended by the Financial Services Reform Act. In the light of this, and for the purposes of this article, a brief historical analysis of the market manipulation prohibition will be presented first. Secondly, the available penalties and remedies for market manipulation are discussed. Thereafter, possible recommendations and significant Australian anti-market abuse enforcement approaches that may be utilised in South Africa are briefly stated. Lastly, concluding remarks are provided.

  9. Historical and current introgression in a Mesoamerican hummingbird species complex: a biogeographic perspective

    Science.gov (United States)

    Jiménez, Rosa Alicia

    2016-01-01

    The influence of geologic and Pleistocene glacial cycles might result in morphological and genetic complex scenarios in the biota of the Mesoamerican region. We tested whether berylline, blue-tailed and steely-blue hummingbirds, Amazilia beryllina, Amazilia cyanura and Amazilia saucerottei, show evidence of historical or current introgression as their plumage colour variation might suggest. We also analysed the role of past and present climatic events in promoting genetic introgression and species diversification. We collected mitochondrial DNA (mtDNA) sequence data and microsatellite loci scores for populations throughout the range of the three Amazilia species, as well as morphological and ecological data. Haplotype network, Bayesian phylogenetic and divergence time inference, historical demography, palaeodistribution modelling, and niche divergence tests were used to reconstruct the evolutionary history of this Amazilia species complex. An isolation-with-migration coalescent model and Bayesian assignment analysis were assessed to determine historical introgression and current genetic admixture. mtDNA haplotypes were geographically unstructured, with haplotypes from disparate areas interdispersed on a shallow tree and an unresolved haplotype network. Assignment analysis of the nuclear genome (nuDNA) supported three genetic groups with signs of genetic admixture, corresponding to: (1) A. beryllina populations located west of the Isthmus of Tehuantepec; (2) A. cyanura populations between the Isthmus of Tehuantepec and the Nicaraguan Depression (Nuclear Central America); and (3) A. saucerottei populations southeast of the Nicaraguan Depression. Gene flow and divergence time estimates, and demographic and palaeodistribution patterns suggest an evolutionary history of introgression mediated by Quaternary climatic fluctuations. High levels of gene flow were indicated by mtDNA and asymmetrical isolation-with-migration, whereas the microsatellite analyses found evidence

  10. Comparing World Economic and Net Energy Metrics, Part 3: Macroeconomic Historical and Future Perspectives

    Directory of Open Access Journals (Sweden)

    Carey W. King

    2015-11-01

    Full Text Available I use energy cost share to characterize the role of energy in the economy. Specifically, I use an estimate of monetary expenditures for primary energy on an annualized basis for forty-four countries from 1978 to 2010 for natural gas, coal, petroleum, and electricity. I show that global energy cost share is significantly correlated to a one-year lag in the change in gross domestic product as well as measures of total factor productivity. Given the historical reduction in the relative cost of energy (including food and fodder for animate power since the start of the Industrial Revolution, combined with a global energy cost share estimate, I conclude that the turn of the 21st Century represents the time period with the cheapest energy in the history of human civilization (to date. This potential historical nadir for energy expenditures around 2000 has important ramifications for strategies to solve future social, economic, and environmental problems such as reducing annual emissions of greenhouse gases (GHGs. Rapidly decreasing annual GHG emissions while internalizing their costs into the economy might feedback to increase energy expenditures to such a degree as to prevent economic growth during that transition.

  11. A historical perspective of Global Warming Potential from Municipal Solid Waste Management

    International Nuclear Information System (INIS)

    Habib, Komal; Schmidt, Jannick H.; Christensen, Per

    2013-01-01

    Highlights: • Five scenarios are compared based on different waste management systems from 1970 to 2010. • Technology development for incineration and vehicular exhaust system throughout the time period is considered. • Compared scenarios show continuous improvement regarding environmental performance of waste management system. • Energy and material recovery from waste account for significant savings of Global Warming Potential (GWP) today. • Technology development for incineration has played key role in lowering the GWP during past five decades. - Abstract: The Municipal Solid Waste Management (MSWM) sector has developed considerably during the past century, paving the way for maximum resource (materials and energy) recovery and minimising environmental impacts such as global warming associated with it. The current study is assessing the historical development of MSWM in the municipality of Aalborg, Denmark throughout the period of 1970 to 2010, and its implications regarding Global Warming Potential (GWP 100 ), using the Life Cycle Assessment (LCA) approach. Historical data regarding MSW composition, and different treatment technologies such as incineration, recycling and composting has been used in order to perform the analysis. The LCA results show a continuous improvement in environmental performance of MSWM from 1970 to 2010 mainly due to the changes in treatment options, improved efficiency of various treatment technologies and increasing focus on recycling, resulting in a shift from net emission of 618 kg CO 2 -eq. tonne −1 to net saving of 670 kg CO 2 -eq. tonne −1 of MSWM

  12. A historical perspective on the economics of the ownership of mineral rights ownership

    Energy Technology Data Exchange (ETDEWEB)

    Cawood, F.T.; Minnitt, R.C.A. [Technikon SA, Florida (South Africa). Dept. of Engineering

    1998-11-01

    Inauguration of the new political dispensation in South Africa, initiated a dynamic period in the historical development of its minerals policy. The process of substituting the current South African mineral policy framework with an acceptable `post apartheid` system, started soon after the 1994 election of the African National Congress (ANC) government. The Green Paper on a Minerals and Mining Policy for South Africa released for public discussion in February 1998, calls for radical transformation in mineral rights ownership. A shift towards exclusive state ownership of mineral rights, away from the present dual system of private and state ownership, is the most significant proposal. The current holders of mineral rights, or their nominees, who lawfully enjoyed security of tenure under past and present mineral laws are opposed to this transformation because mineral rights were often acquired at considerable cost. The situation is compounded by poor public record-keeping and passive mineral rights administration over a very long period. This paper represents a summary of the historical developments leading to the current legislative environment and forms the basis for any discussion on which future sculpturing of South Africa`s policy regarding mineral rights can take place. One cannot plan for the future without considering the past. 21 refs.

  13. A historical perspective of Global Warming Potential from Municipal Solid Waste Management

    Energy Technology Data Exchange (ETDEWEB)

    Habib, Komal, E-mail: koh@kbm.sdu.dk [Institute of Chemical Engineering, Biotechnology and Environmental Technology, University of Southern Denmark, Niels Bohr’s Alle 1, 5230 Odense M (Denmark); Schmidt, Jannick H.; Christensen, Per [Department of Development and Planning, Aalborg University, Fibigerstraede 13, DK-9220 Aalborg OE (Denmark)

    2013-09-15

    Highlights: • Five scenarios are compared based on different waste management systems from 1970 to 2010. • Technology development for incineration and vehicular exhaust system throughout the time period is considered. • Compared scenarios show continuous improvement regarding environmental performance of waste management system. • Energy and material recovery from waste account for significant savings of Global Warming Potential (GWP) today. • Technology development for incineration has played key role in lowering the GWP during past five decades. - Abstract: The Municipal Solid Waste Management (MSWM) sector has developed considerably during the past century, paving the way for maximum resource (materials and energy) recovery and minimising environmental impacts such as global warming associated with it. The current study is assessing the historical development of MSWM in the municipality of Aalborg, Denmark throughout the period of 1970 to 2010, and its implications regarding Global Warming Potential (GWP{sub 100}), using the Life Cycle Assessment (LCA) approach. Historical data regarding MSW composition, and different treatment technologies such as incineration, recycling and composting has been used in order to perform the analysis. The LCA results show a continuous improvement in environmental performance of MSWM from 1970 to 2010 mainly due to the changes in treatment options, improved efficiency of various treatment technologies and increasing focus on recycling, resulting in a shift from net emission of 618 kg CO{sub 2}-eq. tonne{sup −1} to net saving of 670 kg CO{sub 2}-eq. tonne{sup −1} of MSWM.

  14. A historical perspective of Global Warming Potential from Municipal Solid Waste Management.

    Science.gov (United States)

    Habib, Komal; Schmidt, Jannick H; Christensen, Per

    2013-09-01

    The Municipal Solid Waste Management (MSWM) sector has developed considerably during the past century, paving the way for maximum resource (materials and energy) recovery and minimising environmental impacts such as global warming associated with it. The current study is assessing the historical development of MSWM in the municipality of Aalborg, Denmark throughout the period of 1970 to 2010, and its implications regarding Global Warming Potential (GWP(100)), using the Life Cycle Assessment (LCA) approach. Historical data regarding MSW composition, and different treatment technologies such as incineration, recycling and composting has been used in order to perform the analysis. The LCA results show a continuous improvement in environmental performance of MSWM from 1970 to 2010 mainly due to the changes in treatment options, improved efficiency of various treatment technologies and increasing focus on recycling, resulting in a shift from net emission of 618 kg CO(2)-eq.tonne(-1) to net saving of 670 kg CO(2)-eq.tonne(-1) of MSWM. Copyright © 2013 Elsevier Ltd. All rights reserved.

  15. Is hormesis an underestimated factor in the development of herbicide resistance?

    Directory of Open Access Journals (Sweden)

    Belz, Regina G.

    2014-02-01

    Full Text Available The growing impact of herbicide resistant weeds increasingly affects weed management and the delay of resistance evolution has become a major task of chemical weed control. Hormesis and, thus, the phenomenon that low doses of herbicides can boost weed growth could be of importance in this regard since the recommended field rate may represent a low dose for weeds that have evolved resistance to the applied herbicide and, thus, a potential hormetic dose. Applying the field rate may thus not only directly select resistant biotypes, it may also indirectly promote the success and spread of resistant biotypes via hormesis. Nevertheless, hormetic effects in resistant weeds are hitherto merely randomly observed and, thus, a clear quantitative basis to judge the significance of hormesis for resistance evolution is lacking. Therefore, this study aimed at quantifying the degree and frequency of herbicide hormesis in sensitive and resistant weed species in order to provide a first indication of whether the phenomenon deserves consideration as a potential factor contributing to the development of herbicide resistance. In germination assays complete dose-response experiments were conducted with sensitive and resistant biotypes of Matricaria inodora (ALS-target-site resistant; treated with iodosulfuron-methyl-sodium/mesosulfuron-methyl, Eleusine indica (glyphosateresistant; treated with glyphosate, and Chenopodium album (triazine/triazinone-target-site resistant; treated with terbuthylazine. After 10 days of cultivation under controlled conditions plant growth was analyzed by measuring shoot/root length and mass. Results indicated that herbicide hormesis occurred on average with a total frequency of 29% in sensitive/resistant biotypes with an average growth increase of 53% occurring typically within a dose zone exceeding 350fold. Hormetic effects occurred, however, very variable and only for specific endpoints and not plant growth in general. If such a

  16. Growth and yield models in Spain: Historical overview, Contemporary Examples and perspectives

    Energy Technology Data Exchange (ETDEWEB)

    Bravo, F.; Alvarez-Gonzalez, J. G.; Rio, M. del; Barrio, M.; Bonet, J. a.; Bravo-Oviedo, A.; Calama, R.; Castedo-Dorado, F.; Crecente-Campo, F.; Condes, S.; Dieguez-Aranda, U.; Gonzalez-Martinez, S. C.; Lizarralde, I.; Nanos, N.; Madrigal, A.; Martinez-Millan, F. J.; Montero, G.; Ordonez, C.; Palahi, M.; Pique, M.; Rodriguez, F.; Rodriguez-Soalleiro, R.; Rojo, A.; Ruiz-Peinado, R.; Sanchez-Gonzalez, M.; Trasobares, A.; Vazquez-Pique, J.

    2011-07-01

    In this paper we present a review of forest models developed in Spain in recent years for both timber and non timber production and forest dynamics (regeneration, mortality,..). Models developed are whole stand, size (diameter) class and individual-tree. The models developed to date have been developed using data from permanent plots, experimental sites and the National Forest Inventory. In this paper we show the different sub-models developed so far and the friendly use software. Main perspectives of forest modelling in Spain are presented. (Author) 107 refs.

  17. Capital-centric versus knowledge-centric paradigms of human resource management: A historical perspective

    Directory of Open Access Journals (Sweden)

    Chris W. Callaghan

    2016-04-01

    Research purpose: This article relates certain changes in HRM over time to the argument that there has been a shift from an industrial paradigm (on which many human resource [HR] systems, practices and theoretical frameworks are still based to a knowledge paradigm (of knowledge work, in which employee knowledge and skills offer compound advantages that are not substitutable which explains a great deal of the variance in changes of the field over time. Motivation for the study: It is argued that in order for the field to move forward, it may needto bring to the surface certain assumptions and differentiate between theoretical frameworkswhen dealing with knowledge work versus non-knowledge work. Research design, approach and method: This article offers a perspective of HR theory development over time. It is a conceptual/perspectives article and is not qualitative nor quantitative in nature. Further research will be able to test the ideas presented here. Practical/managerial implications: Managers and human resources managers need to differentiate between knowledge and non-knowledge work. The latter is associated with increased heterogeneity and complexity, and differences in power relationships, as knowledge work shifts power away from capital into the hands of skilled knowledge labour.

  18. An historical perspective of the NERVA nuclear rocket engine technology program. Final Report

    International Nuclear Information System (INIS)

    Robbins, W.H.; Finger, H.B.

    1991-07-01

    Nuclear rocket research and development was initiated in the United States in 1955 and is still being pursued to a limited extent. The major technology emphasis occurred in the decade of the 1960s and was primarily associated with the Rover/NERVA Program where the technology for a nuclear rocket engine system for space application was developed and demonstrated. The NERVA (Nuclear Engine for Rocket Vehicle Application) technology developed twenty years ago provides a comprehensive and viable propulsion technology base that can be applied and will prove to be valuable for application to the NASA Space Exploration Initiative (SEI). This paper, which is historical in scope, provides an overview of the conduct of the NERVA Engine Program, its organization and management, development philosophy, the engine configuration, and significant accomplishments

  19. Economists, capitalists, and the making of globalization: North American free trade in comparative-historical perspective.

    Science.gov (United States)

    Fairbrother, Malcolm

    2014-03-01

    Why did globalization happen? Current explanations point to a variety of conditions under which states have made the free market policy changes driving international economic integration since the 1980s. Such accounts disagree, however, about the key actors involved. This article provides a reconciliation, showing how two different combinations of actors, and two different political economic pathways, have led to globalization in recent decades. In developed countries, mobilization by business has been central; elsewhere, technocrats both constrained and empowered by international finance have pursued globalization more independently of business. In both contexts, economists' technical authority has helped legitimate liberalization, despite the limited diffusion of their ideas. The article validates and elaborates this model using a comparative-historical study of how the United States, Canada, and Mexico proposed, negotiated, and ratified agreements for free trade in North America.

  20. Dharmic projects, imperial reservoirs, and new temples of India: An historical perspective on dams in India

    Directory of Open Access Journals (Sweden)

    Morrison Kathleen

    2010-01-01

    Full Text Available As international attention continues to focus on large dam projects across Asia, it is worth noting that conflicts over the politics of and environmental changes caused by dams in India are not new. Population dislocation, siltation, disease, floods caused by catastrophic dam failure, raised water tables, high costs and low returns-all of these concerns, and others, can be discussed in the context of reservoir projects ten, one hundred, or even one thousand years old. In this paper, I identify some of the major issues in the political ecology of contemporary dam projects and show how these same issues have played out in southern India over the last thousand years, suggesting that historical attention to the cultural and political context of reservoir construction might help us to understand some aspects of contemporary conflicts.

  1. Roles of sunlight and natural ventilation for controlling infection: historical and current perspectives.

    Science.gov (United States)

    Hobday, R A; Dancer, S J

    2013-08-01

    Infections caught in buildings are a major global cause of sickness and mortality. Understanding how infections spread is pivotal to public health yet current knowledge of indoor transmission remains poor. To review the roles of natural ventilation and sunlight for controlling infection within healthcare environments. Comprehensive literature search was performed, using electronic and library databases to retrieve English language papers combining infection; risk; pathogen; and mention of ventilation; fresh air; and sunlight. Foreign language articles with English translation were included, with no limit imposed on publication date. In the past, hospitals were designed with south-facing glazing, cross-ventilation and high ceilings because fresh air and sunlight were thought to reduce infection risk. Historical and recent studies suggest that natural ventilation offers protection from transmission of airborne pathogens. Particle size, dispersal characteristics and transmission risk require more work to justify infection control practices concerning airborne pathogens. Sunlight boosts resistance to infection, with older studies suggesting potential roles for surface decontamination. Current knowledge of indoor transmission of pathogens is inadequate, partly due to lack of agreed definitions for particle types and mechanisms of spread. There is recent evidence to support historical data on the effects of natural ventilation but virtually none for sunlight. Modern practice of designing healthcare buildings for comfort favours pathogen persistence. As the number of effective antimicrobial agents declines, further work is required to clarify absolute risks from airborne pathogens along with any potential benefits from additional fresh air and sunlight. Copyright © 2013 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.

  2. Religious morality (and secular humanism) in Western civilization as precursors to medical ethics: A historic perspective

    Science.gov (United States)

    Faria, Miguel A.

    2015-01-01

    In discussing bioethics and the formulation of neuroethics, the question has arisen as to whether secular humanism should be the sole philosophical guiding light, to the exclusion of any discussion (or even mention) of religious morality, in professional medical ethics. In addition, the question has arisen as to whether freedom or censorship should be part of medical (and neuroscience) journalism. Should independent medical journals abstain from discussing certain issues, or should only the major medical journals — i.e., the New England Journal of Medicine (NEJM), the Journal of the American Medical Association (JAMA) or Lancet — be heard, speaking with one “consensual,” authoritative voice? This issue is particularly important in controversial topics impacting medical politics — e.g., public health policy, socio-economics, bioethics, and the so-called redistributive justice in health care. Should all sides be heard when those controversial topics are discussed or only a consensual (monolithic) side? This historical review article discusses those issues and opts for freedom in medical and surgical practice as well as freedom in medical journalism, particularly in opinion pieces such as editorials, commentaries, or letters to the editor, as long as they relate to medicine and, in our special case, to neuroscience and neurosurgery. After answering those questions, and in response to a critical letter to the editor, this review article then expounds comprehensively on the historical and philosophical origins of ethics and religious morality. Necessarily, we discuss the Graeco-Roman legacy and the Judeo-Christian inheritance in the development of ethics and religious morality in Western civilization and their impact on moral conduct in general and on medical and neuroscience ethics in particular. PMID:26110085

  3. Herbicide hormesis to segregate a weed population? – A case study with Tripleurospermum perforatum (Mérat Lainz

    Directory of Open Access Journals (Sweden)

    Belz, Regina G.

    2016-02-01

    Full Text Available Weed populations feature within-population genetic differences. Thus, evaluating mean responses in herbicide treated populations may miss ecologically significant individual responses. Since hormesis can likewise vary between individuals, this study investigated the hypothesis that herbicide hormesis within a high-density weed population is different among slowly-growing individuals, as compared to fast-growing individuals. In a dose-response experiment, Tripleurospermum perforatum (Mérat Lainz was exposed to 12 doses of Atlantis WG (mesosulfuron + iodosulfuron in 24 replicates (50 plants/replicate. Root/shoot growth responses were evaluated as dose-response relationships for the population mean, the 90-97th percentile of the population (fast-growing individuals, and the 5-10th percentile (slow-growing individuals. Growth responses were generally biphasic. Slow-growing individuals had more pronounced hormesis that occurred partially at lower doses as compared to the population mean. With fast-growing individuals, hormesis was instead less pronounced and partially shifted to higher doses. Hence, hormesis was primarily associated with a stimulation of slow-growing individuals, while fast-growing individuals contributed to a lesser extent to the hormetic population response in a dense stand in vitro. This discrepancy may have the potential to segregate an herbicide exposed population and alter its sensitivity in the long-run.

  4. Mechanical fasteners used in historical Siberian shipbuilding: perspectives for metallurgical analysis

    Science.gov (United States)

    Goncharov, A. E.; Mednikov, D. M.; Karelin, N. M.; Nasyrov, I. R.

    2017-10-01

    Recent discoveries of shipwrecked vessels in the northern reaches of the river Yenisei led to a number of questions concerning the history of shipbuilding in Siberia and the technical features of the first vessels of the industrial era to navigate the Northern Sea Route and the Yenisei. One of these questions addresses the features of mechanical fasteners used in the construction of the Siberian vessels. The answer to this question may provide information on how the first vessels, constructed in Siberia during the 1870’s, were able to sail the high seas of the Arctic Ocean and reach European ports. In this paper, we provide a description of iron mechanical fasteners obtained from one shipwrecked vessel and discuss on the perspectives of a metallurgical analysis This research has been funded by a grant of the Russian Fund of Humanities Research (Russian Fund of Fundamental Research) and the Krasnoyarsk Regional Science Fund under Grant number 16-11-24010.

  5. Diversity dynamics operating between students lecturers and management in a historically Black university: The lecturers perspective

    Directory of Open Access Journals (Sweden)

    Michelle S. May

    2012-03-01

    Research purpose: The purpose of the research was to describe the experiences of nine lecturers in a particular HBU. This was undertaken to analyse and interpret the conscious and unconscious diversity dynamics operating in the relationship between the students, lecturers and management, from the lecturers’ perspective. Motivation for the study: The researcher was interested in the nature of the diversity dynamics operating in the relationship between students, lecturers and management in an HBU, as a platform towards understanding diversity dynamics in educational institutions and South African organisations. Research design, approach and method: Qualitative and descriptive research approaches were used. Hermeneutic phenomenology, using the systems psychodynamic perspective, allowed for the description and interpretation of diversity dynamics operating in the relationship between the students, lecturers and management. The data were obtained through in-depth interviews with nine lecturers. Thematic analysis resulted in two broad themes for which a discussion was provided and a research hypothesis formulated. Main findings: Two broad themes manifested, firstly diversity characteristics and secondly struggle skills entrenching the Black and White divide. Practical/managerial implications: The research highlighted the importance of understanding the diversity dynamics operating in the relationship between students, lecturers and management. This was in order to develop our understanding of diversity dynamics operating in educational institutions specifically, and organisations in general. Contribution/value-add: The understanding about diversity dynamics is available for application, by lecturers and management, to form a different understanding of conscious and unconscious factors impacting on the relationship between the three stakeholders, and subsequently the effectiveness of the three stakeholders in their respective roles. This understanding can also be

  6. Therapeutic journery of nitrogen mustard as alkylating anticancer agents: Historic to future perspectives.

    Science.gov (United States)

    Singh, Rajesh K; Kumar, Sahil; Prasad, D N; Bhardwaj, T R

    2018-05-10

    Cancer is considered as one of the most serious health problems today. The discovery of nitrogen mustard as an alkylating agent in 1942, opened a new era in the cancer chemotherapy. This valuable class of alkylating agent exerts its biological activity by binding to DNA, cross linking two strands, preventing DNA replication and ultimate cell death. At the molecular level, nitrogen lone pairs of nitrogen mustard generate a strained intermediate "aziridinium ion" which is very reactive towards DNA of tumor cell as well as normal cell resulting in various adverse side effects alogwith therapeutic implications. Over the last 75 years, due to its high reactivity and peripheral cytotoxicity, numerous modifications have been made in the area of nitrogen mustard to improve its efficacy as well as enhancing drug delivery specifically to tumor cells. This review mainly discusses the medicinal chemistry aspects in the development of various classes of nitrogen mustards (mechlorethamine, chlorambucil, melphalan, cyclophosphamide and steroidal based nitrogen mustards). The literature collection includes the historical and the latest developments in these areas. This comprehensive review also attempted to showcase the recent progress in the targeted delivery of nitrogen mustards that includes DNA directed nitrogen mustards, antibody directed enzyme prodrug therapy (ADEPT), gene directed enzyme prodrug therapy (GDEPT), nitrogen mustard activated by glutathione transferase, peptide based nitrogen mustards and CNS targeted nitrogen mustards. Copyright © 2018 Elsevier Masson SAS. All rights reserved.

  7. Evolutionary systems biology: historical and philosophical perspectives on an emerging synthesis.

    Science.gov (United States)

    O'Malley, Maureen A

    2012-01-01

    Systems biology (SB) is at least a decade old now and maturing rapidly. A more recent field, evolutionary systems biology (ESB), is in the process of further developing system-level approaches through the expansion of their explanatory and potentially predictive scope. This chapter will outline the varieties of ESB existing today by tracing the diverse roots and fusions that make up this integrative project. My approach is philosophical and historical. As well as examining the recent origins of ESB, I will reflect on its central features and the different clusters of research it comprises. In its broadest interpretation, ESB consists of five overlapping approaches: comparative and correlational ESB; network architecture ESB; network property ESB; population genetics ESB; and finally, standard evolutionary questions answered with SB methods. After outlining each approach with examples, I will examine some strong general claims about ESB, particularly that it can be viewed as the next step toward a fuller modern synthesis of evolutionary biology (EB), and that it is also the way forward for evolutionary and systems medicine. I will conclude with a discussion of whether the emerging field of ESB has the capacity to combine an even broader scope of research aims and efforts than it presently does.

  8. The Composition of Cigarette Smoke. An Historical Perspective of Several Polycyclic Aromatic Hydrocarbons

    Directory of Open Access Journals (Sweden)

    Rodgman A

    2014-12-01

    Full Text Available Because of the significant advancements in fractionation, analytical, and characterization technologies since the early 1960s, hundreds of components of complex mixtures have been accurately characterized without the necessity of actually isolating the individual component. This has been particularly true in the case of the complex mixtures tobacco and tobacco smoke. Herein, an historical account of a mid-1950 situation concerning polycyclic aromatic hydrocarbons (PAHs in cigarette smoke is presented. While the number of PAHs identified in tobacco smoke has escalated from the initial PAH, azulene, identified in 1947 to almost 100 PAHs identified by late 1963 to more than 500 PAHs identified by the late 1970s, the number of PAHs isolated individually and characterized by several of the so-called classical chemical means (melting point, mixture melting point, derivative preparation and properties in the mid-1950s and since is relatively few, 14 in all. They were among 44 PAHs identified in cigarette mainstream smoke and included the following PAHs ranging from bicyclic to pentacyclic: Acenaphthylene, 1,2-dihydroacenaphthylene, anthracene, benz[a]anthracene, benzo[a]pyrene, chrysene, dibenz[a, h]anthracene, fluoranthene, 9H-fluorene, naphthalene, 1-methylnaphthalene, 2-methylnaphthalene, phenanthrene, and pyrene. One of them, benzo[a]pyrene, was similarly characterized in another study in 1959 by Hoffmann.

  9. “Grammar-translation” method, a linguistic historic err or of perspective: origins, dynamics and inconsistencies

    Directory of Open Access Journals (Sweden)

    Camilo Andrés Bonilla Carvajal

    2013-07-01

    Full Text Available The Grammar-Translation method is frequently referred to as the traditional ineffective approach par excellence. Such view is often justified by the claim that before the Audiolingual method oral performance in foreign language was not reached, and language classes were reduced to memorizing grammar rules and lists of vocabulary. Nevertheless, this opinion is derived from unproved claims, mainly made by misinformed authors for they offer no compelling empirical evidence to validate their restrictive descriptions where translation is shown as an invalid metacognitive strategy. The aim of this paper is to demonstrate that Grammar-Translation is merely an arbitrary historic label, developed by methodologists and theoreticians to encompass the history of language teaching from 1790 through 1950. References to Grammar-Translation are critically reviewed to make evident they are biased inferences based on partial evidence to account for the existence of any such methodology. The assumption that Grammar-Translation did exist, and that it is the negative model of teaching practices that should be better avoided at all costs, might reflect an unconstructive and unfounded ideological interest of mainstream theoreticians and unsuspecting teachers.

  10. Pelvic Fixation in Adult and Pediatric Spine Surgery: Historical Perspective, Indications, and Techniques: AAOS Exhibit Selection.

    Science.gov (United States)

    Jain, Amit; Hassanzadeh, Hamid; Strike, Sophia A; Menga, Emmanuel N; Sponseller, Paul D; Kebaish, Khaled M

    2015-09-16

    Achieving solid osseous fusion across the lumbosacral junction has historically been, and continues to be, a challenge in spine surgery. Robust pelvic fixation plays an integral role in achieving this goal. The goals of this review are to describe the history of and indications for spinopelvic fixation, examine conventional spinopelvic fixation techniques, and review the newer S2-alar-iliac technique and its outcomes in adult and pediatric patients with spinal deformity. Since the introduction of Harrington rods in the 1960s, spinal instrumentation has evolved substantially. Indications for spinopelvic fixation as a means to achieve lumbosacral arthrodesis include a long arthrodesis (five or more vertebral levels) or use of three-column osteotomies in the lower thoracic or lumbar spine, surgical treatment of high-grade spondylolisthesis, and correction of lumbar deformity and pelvic obliquity. A variety of techniques have been described over the years, including Galveston iliac rods, Jackson intrasacral rods, the Kostuik transiliac bar, iliac screws, and S2-alar-iliac screws. Modern iliac screws and S2-alar-iliac screws are associated with relatively low rates of pseudarthrosis. S2-alar-iliac screws have the advantages of less implant prominence and inline placement with proximal spinal anchors. Collectively, these techniques provide powerful methods for obtaining control of the pelvis in facilitating lumbosacral arthrodesis. Copyright © 2015 by The Journal of Bone and Joint Surgery, Incorporated.

  11. The evolution of the Japanese medical education system: a historical perspective.

    Science.gov (United States)

    Kuwabara, Norimitsu; Yamashita, Miu; Yee, Keolamau; Kurahara, David

    2015-03-01

    The Japanese Medical Education system has been influenced by political events throughout the country's history. From long periods of isolation from the western world to the effect of world wars, Japan's training system for physicians has had to adapt in many ways and will continue to change. The Japanese medical education system was recently compared to the "Galapagos Islands" for its unusual and singular evolution, in a speech by visiting professor Dr. Gordon L. Noel at the University of Tokyo International Research center.1 Japanese medical schools are currently working to increase their students' clinical hours or else these students may not be able to train in the United States for residencies. Knowing the history of the Japanese Medical education system is paramount to understanding the current system in place today. Studying the historical foundation of this system will also provide insight on how the system must change in order to produce better clinicians. This article provides a glimpse into the medical system of another nation that may encourage needed reflection on the state of current healthcare training in the United States.

  12. Death, bereavement and traumatic loss in Israel: a historical and cultural perspective.

    Science.gov (United States)

    Witztum, E; Malkinson, R; Rubin, S S

    2001-01-01

    In the present article, we focus on the experience of bereavement and traumatic loss in Israel and examine the main influences that continue to shape them. For the Jewish population the main features are: religious aspects stemming from Jewish tradition and its variants; the secular and contemporary traditions, the ethos of the Israeli state, and the influence of the struggle to reestablish the Jewish people in its homeland. In an increasingly multicultural society, significant changes are occurring. A series of vignettes of grief and mourning illustrate current issues and practices among religious, secular, kibbutz, Russian and Ethiopian segments of society. The remainder of the article discusses emerging patterns of response to bereavement that are socially constructed and historically situated. We follow the variations in these patterns, from shifting forms of memorialization on the collective level to changes in expressive mood on the individual level, which are mediated by the cultural mosaic of the society. Mental health professionals would benefit from an understanding of the multifaceted fabric of beliefs and cultural-specific customs that shape the mourning rituals and their meanings for the bereaved.

  13. The Historical Perspective of Formation of Offshore Jurisdictions as the Global System of Tax Evasion

    Directory of Open Access Journals (Sweden)

    Synyutka Nataliya G.

    2017-03-01

    Full Text Available The aim of this publication is improving the knowledge about the genesis of formation of offshore jurisdictions. The article characterizes the historical stages of origination of tax havens on the basis of theoretical generalizations and comparing the results of studies and publications on the specified issues. The article identifies the main groups of tax havens: offshores of the colonies of the former British Empire; the European havens; the group of simulators (such as Panama, Uruguay, Dubai, new havens in the countries with transition economy and in African countries. A comprehensive list of offshores in terms of actors by the domestic classification has been provided. The authors suggest, as a timely measures, establishing a coordinated international campaign to counter the aggressive tax planning. For the purpose of stabilization of the internal capital markets, as well as success of the fiscal control, the main directions of the anti-offshore policy have been proposed as follows: unification of the taxation rules for residents and non-residents within the offshore countries; global limitation of the bank secrecy along with transparency of information for the taxation purposes, ensuring transparency of ownership and tracing of end the beneficiaries of assets; changing the model convention for the avoidance of double taxation and the data exchange.

  14. Historical Perspectives and Future Needs in the Development of the Soil Series Concept

    Science.gov (United States)

    Beaudette, Dylan E.; Brevik, Eric C.; Indorante, Samuel J.

    2016-04-01

    The soil series concept is an ever-evolving understanding of soil profile observations, their connection to the landscape, and functional limits on the range in characteristics that affect management. Historically, the soil series has played a pivotal role in the development of soil-landscape theory, modern soil survey methods, and concise delivery of soils information to the end-user-- in other words, soil series is the palette from which soil survey reports are crafted. Over the last 20 years the soil series has received considerable criticism as a means of soil information organization (soil survey development) and delivery (end-user application of soil survey data), with increasing pressure (internal and external) to retire the soil series. We propose that a modern re-examination of soil series information could help address several of the long-standing critiques of soil survey: consistency across survey vintage and political divisions and more robust estimates of soil properties and associated uncertainty. A new library of soil series data would include classic narratives describing morphology and management, quantitative descriptions of soil properties and their ranges, graphical depiction of the relationships between associated soil series, block diagrams illustrating soil-landscape models, maps of series distribution, and a probabilistic representation of a "typical" soil profile. These data would be derived from re-correlation of existing morphologic and characterization data informed by modern statistical methods and regional expertise.

  15. Canadian upstream oil and gas industry profitability: Historical review and future perspectives [with executive summary

    International Nuclear Information System (INIS)

    1991-09-01

    The profitability of the Canadian upstream oil and gas industry is examined by analyzing return on equity and return on capital invested. By all measures and interpretations, the upstream industry has been unprofitable since the mid-1980s; returns generated are far below the industry's own historical cost of capital, and are inadequate relative to other sectors of the Canadian economy and to international oil and gas companies. This poor profitability is attributed to such factors as: overly optimistic price forecasts and healthy cash flows generated in the early 1980s, which led to excess capital spending; poor returns on capital reflective of the physical limitations of the Western Canadian Sedimentary Basin; high capital and operating costs; and a high royalty burden imposed by provincial governments. The consequences of low profitability include inadequate returns to equity investors, a drop in spending on upstream services such as drilling and exploration, a reduced ability of the industry to generate employment, and an adverse effect on the economy of Alberta. Forecasts indicate that the upstream sector is extremely vulnerable to a scenario of relatively flat prices due to high and increasing operating costs and depletion charges, and the significant royalty payments that still are in effect. Little scope is foreseen for industry profitability to return to acceptable levels over the first half of the 1990s. Reduced royalties have the potential to make a significant contribution to improved profitability. 52 figs., 40 tabs

  16. Historical perspective and human consequences of Africanized bee stings in the Americas.

    Science.gov (United States)

    Ferreira, R S; Almeida, R A M B; Barraviera, S R C S; Barraviera, B

    2012-01-01

    In 1956, Africanized bees began to spread in the American continent from southern Brazil, where original African bees mated with European bees. A few years later, in 1990, these Africanized bees reached the United States and were found in Texas. Currently, these hybrid bees are found in several North American states and will probably reach the Canadian border in the future. Although the presence of Africanized bees had produced positive effects on Brazilian economy, including improvement in crop pollination and in honey production, turning Brazil into a major exporter, the negative impacts-such as swarming, aggressive behavior, and the ability to mass attack-resulted in serious and fatal envenomation with humans and animals. Victims of bee attacks usually develop a severe envenomation syndrome characterized by the release of a large amount of cytokines [interleukins (IL) IL-1, IL-6, IL-8], and tumor necrosis factor (TNF). Subsequently, such cytokines produce an acute inflammatory response that triggers adverse effects on skeletal muscles; bone marrow; hepatic and renal functions; and cardiovascular, central nervous, and immune systems. Finally, the aim of the present review is to study historical characteristics and current status of Africanized bees' spread, the composition of their venom, the impact of the bees on the Brazilian economy and ecology, and clinical aspects of their stings including immune response, and to suggest a protocol for bee sting management since there is no safe and effective antivenom available.

  17. Why New Hybrid Organizations are Formed: Historical Perspectives on Epistemic and Academic Drift.

    Science.gov (United States)

    Kaiserfeld, Thomas

    2013-06-01

    By comparing three types of hybrid organizations-18th-century scientific academies, 19th-century institutions of higher vocational education, and 20th-century industrial research institutes-it is the purpose here to answer the question of why new hybrid organizations are continuously formed. Traditionally, and often implicitly, it is often assumed that emerging groups of potential knowledge users have their own organizational preferences and demands influencing the setup of new hybrid organizations. By applying the concepts epistemic and academic drift, it will be argued here, however, that internal organizational dynamics are just as important as changing historical conjunctures in the uses of science when understanding why new hybrid organizations are formed. Only seldom have older hybrid organizations sought to make themselves relevant to new categories of knowledge users as the original ones have been marginalized. Instead, they have tended to accede to ideals supported by traditional academic organizations with higher status in terms of knowledge management, primarily universities. Through this process, demand has been generated for the founding of new hybrid organizations rather than the transformation of existing ones. Although this study focuses on Swedish cases, it is argued that since Sweden strove consistently to implement existing international policy trends during the periods in question, the observations may be generalized to apply to other national and transnational contexts.

  18. [Cocaine: historical background, neurobiology of the addiction and relapse and therapeutic perspectives].

    Science.gov (United States)

    Silva, M I; Citó, M C; Vasconcelos, P F; Vasconcelos, S M; Sousa, F C

    2010-01-01

    Following more than a century of cocaine hydrochloride extraction from Erythroxylon coca, this drug remains representing a serious social and public health problema around the world. This paper intends to provide a review about the cocaine theme, focusing on historical background and on its different neurotransmission systems, as well as addresses therapeutics aspects about drug addiction. Electronic search in databases Medline, Pubmed and Lilacs was accomplished in order to select classics and recent studies relevant to the discussion of issue addressed. Previous studies have shown high vulnerability to relapse to cocaine seeking following prolonged withdrawal periods. Such behavioral consequences have been cre-dited to induced changes in brain neurotransmitters provoked by repeated cocaine use. In recent years, the growing abuse of this drug has mobilized researchers worldwide in seeking for new therapies that reduce the behavioral and neurochemical changes resulting from addiction. Numerous advances regarding the treatment of cocaine abuse and dependence have emerged in recent years. However, researche aiming at a safe and effective users' pharmacological treatment remain necessary and should be continued.

  19. Has player development in men's tennis really changed? An historical rankings perspective.

    Science.gov (United States)

    Bane, Michael Kenneth; Reid, Machar; Morgan, Stuart

    2014-01-01

    Tennis federations are regularly faced with decisions regarding which athletes should be supported in financial terms, and for how long. The financial investments can be considerable, given the cost of competing on tour has been estimated at a minimum $121,000 per year and only the top 130 professionally ranked athletes earned enough prize money to cover this cost in 2012. This study investigates key points of progression in tennis players' careers, to determine how these have changed over time and how that evolution may inform talent development. Approximately 400,000 weekly rankings for 273 male professional tennis players between 1985 and 2010 were compiled, and historical trends in the time taken to reach career milestones were investigated by least-squares regression. The time between earning a first professional ranking point and entry into the Top 100 significantly increased over time for all considered athletes. This was at the detriment of time spent within the Top 100 for some athletes. Career peak Top 50-100 athletes have shown an increase in longevity. These results assist tennis federations in assessing the progress of developing athletes and highlight the evolving nature of the competition for top players.

  20. Women's leadership in neuropsychology: historical perspectives, present trends, and future directions.

    Science.gov (United States)

    Sachs, Bonnie C; Benitez, Andreana; Buelow, Melissa T; Gooding, Amanda; Schaefer, Lynn A; Sim, Anita H; Tussey, Chriscelyn M; Shear, Paula K

    2018-02-01

    Although psychology has become a female-dominated field, this pattern of gender representation has not held true within the specialty of neuropsychology. In recent years more women have been pursuing careers in neuropsychology, and while the balance of male and female neuropsychologists as a whole has shifted, it is unclear whether the gender composition of leadership has also changed. Our goal was to survey various neuropsychological organizations, training programs, editorial boards, and organizations granting board certification to determine the current gender composition of leadership positions within neuropsychology. A literature review was conducted to examine past trends of gender composition in neuropsychology, psychology, medicine, and academia. Data on current gender compositions of the field were culled from publicly available websites and through personal communication with representatives from major psychological and neuropsychological organizations. We found that the overall composition of the field has changed over time, but notable gender disparities in leadership positions remain. Women still comprise the minority of leadership positions within most neuropsychological organizations, editorial boards for neuropsychology journals, and fellow positions in major neuropsychological organizations. More equitable representation has been achieved in the directorships of training programs and ABPP/ABCN board certification. We review the historical trends in gender discrepancies in leadership in neuropsychology and discuss these within the broader arenas of academia, research, and medicine. We conclude with a summary addressing potential causes for these discrepancies, including work-life balance issues, discrimination, institutional bias, and various other factors. We also provide pragmatic suggestions to help address these continued disparities.

  1. Vectorcardiographic diagnostic & prognostic information derived from the 12-lead electrocardiogram: Historical review and clinical perspective.

    Science.gov (United States)

    Man, Sumche; Maan, Arie C; Schalij, Martin J; Swenne, Cees A

    2015-01-01

    In the course of time, electrocardiography has assumed several modalities with varying electrode numbers, electrode positions and lead systems. 12-lead electrocardiography and 3-lead vectorcardiography have become particularly popular. These modalities developed in parallel through the mid-twentieth century. In the same time interval, the physical concepts underlying electrocardiography were defined and worked out. In particular, the vector concept (heart vector, lead vector, volume conductor) appeared to be essential to understanding the manifestations of electrical heart activity, both in the 12-lead electrocardiogram (ECG) and in the 3-lead vectorcardiogram (VCG). Not universally appreciated in the clinic, the vectorcardiogram, and with it the vector concept, went out of use. A revival of vectorcardiography started in the 90's, when VCGs were mathematically synthesized from standard 12-lead ECGs. This facilitated combined electrocardiography and vectorcardiography without the need for a special recording system. This paper gives an overview of these historical developments, elaborates on the vector concept and seeks to define where VCG analysis/interpretation can add diagnostic/prognostic value to conventional 12-lead ECG analysis. Copyright © 2015 Elsevier Inc. All rights reserved.

  2. Alternative explanations of the cosmic microwave background: A historical and an epistemological perspective

    Science.gov (United States)

    Ćirković, Milan M.; Perović, Slobodan

    2018-05-01

    We historically trace various non-conventional explanations for the origin of the cosmic microwave background and discuss their merit, while analyzing the dynamics of their rejection, as well as the relevant physical and methodological reasons for it. It turns out that there have been many such unorthodox interpretations; not only those developed in the context of theories rejecting the relativistic ("Big Bang") paradigm entirely (e.g., by Alfvén, Hoyle and Narlikar) but also those coming from the camp of original thinkers firmly entrenched in the relativistic milieu (e.g., by Rees, Ellis, Rowan-Robinson, Layzer and Hively). In fact, the orthodox interpretation has only incrementally won out against the alternatives over the course of the three decades of its multi-stage development. While on the whole, none of the alternatives to the hot Big Bang scenario is persuasive today, we discuss the epistemic ramifications of establishing orthodoxy and eliminating alternatives in science, an issue recently discussed by philosophers and historians of science for other areas of physics. Finally, we single out some plausible and possibly fruitful ideas offered by the alternatives.

  3. Social network analysis in the study of nonhuman primates: A historical perspective

    Science.gov (United States)

    Brent, Lauren J.N.; Lehmann, Julia; Ramos-Fernández, Gabriel

    2011-01-01

    Advances over the last fifteen years have made social network analysis (SNA) a powerful tool for the study of nonhuman primate social behavior. Although many SNA-based techniques have been only very recently adopted in primatological research, others have been commonly used by primatologists for decades. The roots of SNA also stem from some of the same conceptual frameworks as the majority of nonhuman primate behavioral research. The rapid development of SNA in recent years has led to questions within the primatological community of where and how SNA fits within this field. We aim to address these questions by providing an overview of the historical relationship between SNA and the study of nonhuman primates. We begin with a brief history of the development of SNA, followed by a detailed description of the network-based visualization techniques, analytical methods and conceptual frameworks which have been employed by primatologists since as early as the 1960s. We also introduce some of the latest advances to SNA, thereby demonstrating that this approach contains novel tools for study of nonhuman primate social behavior which may be used to shed light on questions that cannot be addressed fully using more conventional methods. PMID:21433047

  4. A brief historical perspective on the advent of brain oscillations in the biological and psychological disciplines.

    Science.gov (United States)

    Karakaş, Sirel; Barry, Robert J

    2017-04-01

    We aim to review the historical evolution that has led to the study of the brain (body)-mind relationship based on brain oscillations, to outline and illustrate the principles of neuro-oscillatory dynamics using research findings. The paper addresses the relevant developments in behavioral sciences after Wundt established the science of psychology, and developments in the neurosciences after alpha and gamma oscillations were discovered by Berger and Adrian, respectively. Basic neuroscientific studies have led to a number of principles: (1) spontaneous EEG is composed of a set of oscillatory components, (2) the brain responds with oscillatory activity, (3) poststimulus oscillatory activity is a function of prestimulus activity, (4) the brain response results from a superposition of oscillatory components, (5) there are multiplicities with regard to oscillations and functions, and (6) oscillations are spatially integrated. Findings of clinical studies suggest that oscillatory responses can serve as biomarkers for neuropsychiatric disorders. However, the field of psychology is still making limited use of neuro-oscillatory dynamics for a bio-behavioral understanding of cognitive-affective processes. Copyright © 2016 Elsevier Ltd. All rights reserved.

  5. Lessons from the past: Historical perspectives of mental health in the Eastern Cape

    Directory of Open Access Journals (Sweden)

    Kiran Sukeri

    2014-07-01

    Full Text Available The development of mental health services in the Eastern Cape Province is inextricably entwined in South Africa’s colonial history and the racist policy of apartheid. Prior to the development of mental hospitals, mental health services were provided through a network of public and mission hospitals. This paper explores the development of early hospital and mental health services in the Eastern Cape from the time of the Cape Colony to the dissolution of apartheid in 1994, and highlights the influence of colonialism, race and legislation in the development of mental health services in this province. The objective is to provide a background of mental health services in order to identify the historical factors that have had an impact on the current shortcomings in the provision of public sector mental health services in the province. This information will assist in the future planning and development of a new service for the province without the stigma of the past. This research indicates that one lesson from the past should be the equitable distribution of resources for the provision of care for all that inhabit this province, as enshrined in South Africa’s constitution.

  6. Potable water for a city: a historic perspective from Bruges, Belgium

    Science.gov (United States)

    Vandenbohede, A.; Vandevyvere, E.

    2014-06-01

    Contributing to the optimisation of drinking-water supplies is a key responsibility for professional hydrogeologists. Thus, it is interesting to look back and put current-day practices in the framework of historic evolution and past achievements. The water supply of Bruges (Belgium), with an innovative supply system already established by the end of the 13th century, forms an interesting case study. The supply system consisted of an underground network of pipes feeding public and private wells. A special construction, the Water House, was built to overcome a topographical height difference. Population growth and industrial expansion during the 19th century increased the water demand and new solutions were necessary. Tap water became available from 1925 onwards and, as a stopgap measure to meet demand, deep groundwater was used. This invoked a lively debate among the city council, scientists and entrepreneurs, whereby both water quality and quantity were discussed. Although based on a lack of modern understanding of the groundwater system, some arguments, both pro or contra, look very familiar to current-day hydrogeologists.

  7. Historical and contemporary perspectives on children's diets: is choice always in the patients' best interest?

    Science.gov (United States)

    Denny, G; Sundvall, P; Thornton, S J; Reinarz, J; Williams, A N

    2010-06-01

    On 29 March 1744, Thomasin Grace, a 13-year-old girl, was the first inpatient admitted to the Northampton General Infirmary (later the Northampton General Hospital). Inpatient hospital diets, then and now, are mainstays of effective patient treatment. In the mid-18th century there were four prescribed diets at Northampton: 'full', 'milk', 'dry' and 'low'. Previous opinions concerning these four diets were unfavourable, but had not been based upon an individual dietetic assessment. Thomasin would most likely have been given the milk diet, but use of the full diet cannot be excluded. 'Grace Everyman' is Thomasin's modern equivalent. Under current NHS guidelines Thomasin would be considered a paediatric patient, but in 1744 she would have been considered as an adult. This study undertakes a full dietetic analysis of all the prescribed diets available for Thomasin in 1744 and compares this against random choices for Grace from the 2009 inpatient menu from the paediatric (Paddington) ward, and the adult ward inpatient menu at the Northampton General Hospital. The results show that, for Thomasin, the 1744 milk and full diets met the current advised nutritional requirements for adequate dietary intake. However, for Grace, the present 2009 Paddington and adult ward menu, although generally meeting nutritional requirements, could, if Grace or her carer consistently chose poorly during a prolonged inpatient stay, lead to inadequate nutrition. This challenges assumptions that hospital diets were historically inadequate, and that choice in present day equates with satisfactory nutritional intake.

  8. A Historical Perspective on Local Environmental Movements in Japan: Lessons for the Transdisciplinary Approach on Water Resource Governance

    Science.gov (United States)

    Oh, T.

    2014-12-01

    Typical studies on natural resources from a social science perspective tend to choose one type of resource—water, for example— and ask what factors contribute to the sustainable use or wasteful exploitation of that resource. However, climate change and economic development, which are causing increased pressure on local resources and presenting communities with increased levels of tradeoffs and potential conflicts, force us to consider the trade-offs between options for using a particular resource. Therefore, the transdisciplinary approach that accurately captures the advantages and disadvantages of various possible resource uses is particularly important in the complex social-ecological systems, where concerns about inequality with respect to resource use and access have become unavoidable. Needless to say, resource management and policy require sound scientific understanding of the complex interconnections between nature and society, however, in contrast to typical international discussions, I discuss Japan not as an "advanced" case where various dilemmas have been successfully addressed by the government through the optimal use of technology, but rather as a nation seeing an emerging trend that is based on a awareness of the connections between local resources and the environment. Furthermore, from a historical viewpoint, the nexus of local resources is not a brand-new idea in the experience of environmental governance in Japan. There exist the local environment movements, which emphasized the interconnection of local resources and succeeded in urging the governmental action and policymaking. For this reason, local movements and local knowledge for the resource governance warrant attention. This study focuses on the historical cases relevant to water resource management including groundwater, and considers the contexts and conditions to holistically address local resource problems, paying particular attention to interactions between science and society. I

  9. Using historical perspective in designing discovery learning on Integral for undergraduate students

    Science.gov (United States)

    Abadi; Fiangga, S.

    2018-01-01

    In the course of Integral Calculus, to be able to calculate an integral of a given function is becoming the main idea in the teaching beside the ability in implementing the application of integral. The students tend to be unable to understand the conceptual idea of what is integration actually. One of the promising perspectives that can be used to invite students to discover the idea of integral is the History and Pedagogy Mathematics (HPM). The method of exhaustion and indivisible appear in the discussion on the early history of area measurement. This paper study will discuss the designed learning activities based on the method of exhaustion and indivisible in providing the undergraduate student’s discovery materials for integral using design research. The designed learning activities were conducted into design experiment that consists of three phases, i.e., preliminary, design experimental, and teaching experiment. The teaching experiment phase was conducted in two cycles for refinement purpose. The finding suggests that the implementation of the method of exhaustion and indivisible enable students to reinvent the idea of integral by using the concept of derivative.

  10. A free church perspective on military chaplains role in its historical context

    Directory of Open Access Journals (Sweden)

    Neil E. Allison

    2016-12-01

    Full Text Available The waning influence of Christianity in the United Kingdom’s armed forces since 1960 and the growing ignorance of personnel who have ties to a particular denomination, gave rise to a new assessment of the military chaplain in a modern and postmodern context. This article gives an overview of the practice during the two world wars and after the 1960s. It also gives an overview of the debate on the current role of the military chaplain, especially the beliefs of Herspring, Zahn, Coleman and McCormack, and eventually set up a role model from a Free Church perspective. It is shown that an operating model that is only defined in pastoral terms does not satisfy. The pastoral and spiritual definition, in terms of a liminal serving as an alternative, is suggested because it frees the chaplain to act more independent and also describes the best practice that has always prevailed in the British army.

  11. Supply/Demand in Radiology: A Historical Perspective and Comparison to other Labor Markets.

    Science.gov (United States)

    Sharafinski, Mark E; Nussbaum, David; Jha, Saurabh

    2016-02-01

    There has been attention on the job market recently and on radiology's supply/demand calculus. Supply is influenced by the number of trained radiologists, while demand is driven by demographics and technological innovation. We analyze the supply of radiologists historically and compare to other labor markets-medical and non-medical, domestic and foreign. We review National Resident Matching Program data in radiology and several other specialties from 1991 to 2015. We also review surveys, physician recruitment data, and peer-reviewed commentaries on medical specialty job markets. Trends are compared across specialties. The regulation of American medical training is compared to that in the United Kingdom and to a nonmedical labor market, unionized theatrical stage employees. Radiology residency positions have increased since 1998 despite a downturn in the job market. This expansion coincides with a decreasing percentage of positions filled by domestic graduates. A similar trend has been seen in pathology, a notoriously oversupplied specialty. Conversely, other specialties have maintained their proportion of domestic graduates by way of limited supply or implicit demand. The radiology job market is currently oversupplied, primarily a result of increasing residency positions despite indicators of decreasing demand. The percentage of residency positions filled by domestic graduates has decreased during the same period, suggesting that medical student interest is responsive to the market. Other specialties, particularly pathology, demonstrate the dangers of chronic oversupply. We advocate a reduction of radiology residency positions such that supply closely approximates demand without exceeding it. Additional measures may be taken, if necessary, to restore market equilibrium in the event of a mild undersupply. Copyright © 2015 The Association of University Radiologists. Published by Elsevier Inc. All rights reserved.

  12. Childhood central nervous system leukemia: historical perspectives, current therapy, and acute neurological sequelae

    Energy Technology Data Exchange (ETDEWEB)

    Laningham, Fred H. [St. Jude Children' s Research Hospital, Division of Diagnostic Imaging, Department of Radiological Sciences, Memphis, TN (United States); University of Tennessee Health Sciences Center, Memphis, TN (United States); Kun, Larry E. [St. Jude Children' s Research Hospital, Division of Radiation Oncology, Department of Radiological Sciences, Memphis, TN (United States); University of Tennessee Health Sciences Center, Memphis, TN (United States); Reddick, Wilburn E.; Ogg, Robert J. [St. Jude Children' s Research Hospital, Division of Translational Imaging Research, Department of Radiological Sciences, Memphis, TN (United States); Morris, E.B. [St. Jude Children' s Research Hospital, Department of Oncology, Memphis, TN (United States); Pui, Ching-Hon [St. Jude Children' s Research Hospital, Department of Oncology, Memphis, TN (United States); University of Tennessee Health Sciences Center, Memphis, TN (United States)

    2007-11-15

    During the past three decades, improvements in the treatment of childhood leukemia have resulted in high cure rates, particularly for acute lymphoblastic leukemia (ALL). Unfortunately, successful therapy has come with a price, as significant morbidity can result from neurological affects which harm the brain and spinal cord. The expectation and hope is that chemotherapy, as a primary means of CNS therapy, will result in acceptable disease control with less CNS morbidity than has been observed with combinations of chemotherapy and radiotherapy over the past several decades. In this review we discuss the poignant, historical aspects of CNS leukemia therapy, outline current methods of systemic and CNS leukemia therapy, and present imaging findings we have encountered in childhood leukemia patients with a variety of acute neurological conditions. A major objective of our research is to understand the neuroimaging correlates of acute and chronic effects of cancer and therapy. Specific features related to CNS leukemia and associated short-term toxicities, both disease- and therapy-related, are emphasized in this review with the specific neuroimaging findings. Specific CNS findings are similarly important when treating acute myelogenous leukemia (AML), and details of leukemic involvement and toxicities are also presented in this entity. Despite contemporary treatment approaches which favor the use of chemotherapy (including intrathecal therapy) over radiotherapy in the treatment of CNS leukemia, children still occasionally experience morbid neurotoxicity. Standard neuroimaging is sufficient to identify a variety of neurotoxic sequelae in children, and often suggest specific etiologies. Specific neuroimaging findings frequently indicate a need to alter antileukemia therapy. It is important to appreciate that intrathecal and high doses of systemic chemotherapy are not innocuous and are associated with acute, specific, recognizable, and often serious neurological

  13. Skyscape of an Amazonian Diaspora: Arawak Astronomy in Historical Comparative Perspective

    Science.gov (United States)

    Jara, Fabiola

    The title of this article "Arawak Astronomy" suggests that the research matter concerns the astronomy of an already well-defined ethnographic entity. This however does not do justice to the complexities of Arawak (pre)history. This contribution aims to discuss and connect the available historical and ethnographic data on Arawak astronomies as gathered by the author (Jara 2000), with the most recent research on the archeology and comparative linguistics of the Arawak diaspora. The article argues that Arawak astronomy has to be related to the cultural and sociopolitical continuities and discontinuities of the Arawak diaspora throughout the lowlands of tropical South America. This article recognizes the need to consider Arawak astronomy has an object to be discovered and explained within its local and regional contexts. Notwithstanding these remarks, based on a sustained examination of ethnohistorical and ethnographic sources, this article proposes that Arawak astronomy can be characterized by at least four elements: firstly, a horizon system of observation which combines the observation of the solar solstices and equinoxes with the near heliacal and near cosmic rising or setting of at least seven star groups - the Pleiades, the Hyades, the upper stars of the constellation of Scorpius (including α Sco), Corvus, the Belt of Orion, several stars near Sirius, and the Milky Way. Secondly, the association of the rising and setting of these star groups with the seasonal cycle, mainly with the start and/or of the end of rainy and dry seasons. Thirdly, the widespread association of the stars of the year (most commonly the Pleiades but sometimes Orion or the head of Scorpius) with the beginning of the agricultural cycle and consequently with the end of the heavy rains announcing the time to plant the new fields. The last and fourth commonality are the inscriptions or markings of the origin of the stars in the local landscape, lakes, mountains, and other salient landscape

  14. Childhood central nervous system leukemia: historical perspectives, current therapy, and acute neurological sequelae

    International Nuclear Information System (INIS)

    Laningham, Fred H.; Kun, Larry E.; Reddick, Wilburn E.; Ogg, Robert J.; Morris, E.B.; Pui, Ching-Hon

    2007-01-01

    During the past three decades, improvements in the treatment of childhood leukemia have resulted in high cure rates, particularly for acute lymphoblastic leukemia (ALL). Unfortunately, successful therapy has come with a price, as significant morbidity can result from neurological affects which harm the brain and spinal cord. The expectation and hope is that chemotherapy, as a primary means of CNS therapy, will result in acceptable disease control with less CNS morbidity than has been observed with combinations of chemotherapy and radiotherapy over the past several decades. In this review we discuss the poignant, historical aspects of CNS leukemia therapy, outline current methods of systemic and CNS leukemia therapy, and present imaging findings we have encountered in childhood leukemia patients with a variety of acute neurological conditions. A major objective of our research is to understand the neuroimaging correlates of acute and chronic effects of cancer and therapy. Specific features related to CNS leukemia and associated short-term toxicities, both disease- and therapy-related, are emphasized in this review with the specific neuroimaging findings. Specific CNS findings are similarly important when treating acute myelogenous leukemia (AML), and details of leukemic involvement and toxicities are also presented in this entity. Despite contemporary treatment approaches which favor the use of chemotherapy (including intrathecal therapy) over radiotherapy in the treatment of CNS leukemia, children still occasionally experience morbid neurotoxicity. Standard neuroimaging is sufficient to identify a variety of neurotoxic sequelae in children, and often suggest specific etiologies. Specific neuroimaging findings frequently indicate a need to alter antileukemia therapy. It is important to appreciate that intrathecal and high doses of systemic chemotherapy are not innocuous and are associated with acute, specific, recognizable, and often serious neurological

  15. A historical perspective on soil organic carbon in Mediterranean cropland (Spain, 1900-2008).

    Science.gov (United States)

    Aguilera, Eduardo; Guzmán, Gloria I; Álvaro-Fuentes, Jorge; Infante-Amate, Juan; García-Ruiz, Roberto; Carranza-Gallego, Guiomar; Soto, David; González de Molina, Manuel

    2018-04-15

    Soil organic carbon (SOC) management is key for soil fertility and for mitigation and adaptation to climate change, particularly in desertification-prone areas such as Mediterranean croplands. Industrialization and global change processes affect SOC dynamics in multiple, often opposing, ways. Here we present a detailed SOC balance in Spanish cropland from 1900 to 2008, as a model of a Mediterranean, industrialized agriculture. Net Primary Productivity (NPP) and soil C inputs were estimated based on yield and management data. Changes in SOC stocks were modeled using HSOC, a simple model with one inert and two active C pools, which combines RothC model parameters with humification coefficients. Crop yields increased by 227% during the studied period, but total C exported from the agroecosystem only increased by 73%, total NPP by 30%, and soil C inputs by 20%. There was a continued decline in SOC during the 20th century, and cropland SOC levels in 2008 were 17% below their 1933 peak. SOC trends were driven by historical changes in land uses, management practices and climate. Cropland expansion was the main driver of SOC loss until mid-20th century, followed by the decline in soil C inputs during the fast agricultural industrialization starting in the 1950s, which reduced harvest indices and weed biomass production, particularly in woody cropping systems. C inputs started recovering in the 1980s, mainly through increasing crop residue return. The upward trend in SOC mineralization rates was an increasingly important driver of SOC losses, triggered by irrigation expansion, soil cover loss and climate change-driven temperature rise. Copyright © 2017 Elsevier B.V. All rights reserved.

  16. Territorial Contradictions of the Rise of China: Geopolitics, Nationalism and Hegemony in Comparative-Historical Perspective

    Directory of Open Access Journals (Sweden)

    Sahan Savas Karatasli

    2017-02-01

    Full Text Available There is debate in the literature regarding whether China can become a new world hegemonic power in the 21st century. Most existing analyses focus on economic aspects of world hegemony-building processes and ignore its macro-political dimensions. This article starts with the premise that reshaping the geopolitical configuration of the inter-state system is an important part of world hegemony-building processes. One of the ways in which previous and current world hegemonic powers established their world hegemonies was through the inclusion of new nations by co-opting, supporting or sometimes selectively leading a section of nationalist movements into independence. Our comparative analysis shows that, as of now, contemporary China has not been following this historical pattern. Compared to Mao-era China, which was perceived as a champion of national liberation—at least when colonial and semi-colonial areas were at stake—today’s People’s Republic of China (PRC is emerging as a champion of the global geo-political status quo. The current Chinese government is not actively pursuing the transformation of the inter-state system or seeking to create instabilities at different levels. This is because, unlike previous and current world hegemonic powers, during its rise to global preeminence, Chinese territorial integrity has been challenged due to rapid escalation of nationalist/secessionist movements within its own state boundaries. Hence, the PRC's foreign policy has consistently been concerned with creating and preserving macro-political stability at national and international levels.

  17. Sulfate Salts in Gasoline and Ethanol Fuels -- Historical Perspective and Analysis of Available Data

    Energy Technology Data Exchange (ETDEWEB)

    McCormick, Robert L. [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Alleman, Teresa [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Yanowitz, Janet [Ecoengineering, Inc., Sharonville, OH (United States)

    2017-09-21

    This report reviews the chemistry of sulfate salts dissolved in ethanol and gasoline, potential sources of sulfate salts in ethanol and gasoline, the history of consumer vehicle issues with sulfate salt deposits in the early 2000s, and the corresponding changes to the denatured fuel ethanol specification. Recommendations for future research are provided. During a period of rapid market expansion in 2004-05, issues were reported with vehicles running on E10 provided by certain suppliers in some markets. It was commonly believed that these vehicle problems were caused by sulfate salts precipitating from the fuel. Investigators identified sodium sulfate, and in one case also ammonium sulfate, as the predominate salts found in the engines. Several stakeholders believed the issue was excess sulfate ions in the ethanol portion of the E10, and in 2005 the ASTM specification for ethanol (D4806) was modified to include a 4-part per million (ppm) limit on sulfate ions. While there have been no further reports of consumer vehicle issues, the recently approved increase of ethanol in gasoline from 10 to 15 volume percent has resulted in renewed interest in the sulfate ion concentration in fuel ethanol. This report reviews published data on the solubility of sulfate salts in ethanol. The possible sources of sulfate anions and charge balancing cations (such as sodium) in fuel ethanol and petroleum derived blendstocks are discussed. Examination of historical information on the consumer vehicle issues that occurred in 2004-2005 reveals that a source of sodium or ammonium ions, required for the formation of the observed insoluble salts, was never identified. Recommendations for research to better understand sulfate salt solubility issues in ethanol, hydrocarbon blendstocks, and ethanol-gasoline blends are presented.

  18. Twenty years of the G protein-coupled estrogen receptor GPER: Historical and personal perspectives.

    Science.gov (United States)

    Barton, Matthias; Filardo, Edward J; Lolait, Stephen J; Thomas, Peter; Maggiolini, Marcello; Prossnitz, Eric R

    2018-02-01

    Estrogens play a critical role in many aspects of physiology, particularly female reproductive function, but also in pathophysiology, and are associated with protection from numerous diseases in premenopausal women. Steroids and the effects of estrogen have been known for ∼90 years, with the first evidence for a receptor for estrogen presented ∼50 years ago. The original ancestral steroid receptor, extending back into evolution more than 500 million years, was likely an estrogen receptor, whereas G protein-coupled receptors (GPCRs) trace their origins back into history more than one billion years. The classical estrogen receptors (ERα and ERβ) are ligand-activated transcription factors that confer estrogen sensitivity upon many genes. It was soon apparent that these, or novel receptors may also be responsible for the "rapid"/"non-genomic" membrane-associated effects of estrogen. The identification of an orphan GPCR (GPR30, published in 1996) opened a new field of research with the description in 2000 that GPR30 expression is required for rapid estrogen signaling. In 2005-2006, the field was greatly stimulated by two studies that described the binding of estrogen to GPR30-expressing cell membranes, followed by the identification of a GPR30-selective agonist (that lacked binding and activity towards ERα and ERβ). Renamed GPER (G protein-coupled estrogen receptor) by IUPHAR in 2007, the total number of articles in PubMed related to this receptor recently surpassed 1000. In this article, the authors present personal perspectives on how they became involved in the discovery and/or advancement of GPER research. These areas include non-genomic effects on vascular tone, receptor cloning, molecular and cellular biology, signal transduction mechanisms and pharmacology of GPER, highlighting the roles of GPER and GPER-selective compounds in diseases such as obesity, diabetes, and cancer and the obligatory role of GPER in propagating cardiovascular aging, arterial

  19. Energy use in the U.S. steel industry: a historical perspective and future opportunities

    Energy Technology Data Exchange (ETDEWEB)

    Stubbles, John

    2000-09-01

    The U.S. steel industry has taken enormous strides over the past decades to reduce its energy consumption; since the end of World War II, the industry has reduced its energy intensity (energy use per shipped ton) by 60 percent. Between 1990 and 1998 alone, intensity has dropped from 20 to 18 million Btu (MBtu) per ton. This figure is projected to decrease to 15 MBtu/ton by 2010 with an asymptotic trend towards 14 MBtu/ton. Domestic shipments are projected to flatten out over the next decade to around 105 million tons which means that total energy consumption will also decrease. Historically, the steel industry has accounted for about 6 percent of U.S. energy consumption. Today, that figure is less than 2 percent and will decrease further to 1.5 percent by 2010. The primary causes for the decrease in energy consumption since WWII are: The use of pellets in the blast furnace and the application of new technology in the ironmaking process to further reduce fuel rates per net ton of hot metal (NTHM); The total replacement of the open hearth process by basic oxygen and electric furnaces; The almost total replacement of ingot casting by continuous casting (which improved yield dramatically and thus reduced the tons of raw steel required per ton of shipments); and The growth of the electric furnace sector of the industry at the expense of hot metal-based processes (which has also stimulated scrap recycling so that about 55 percent of ''new'' steel is now melted from scrap steel). This report focuses on the concept of good practices (i.e., those that are sustainable and can use today's technology). If all the industry could operate on this basis, the additional savings per ton could total 2 MBtu, As further restructuring occurs and the swing from hot metal-based to electric furnace-based production continues, the average consumption will approach the good practice energy per ton. Further savings will accrue through new technology, particularly in

  20. Energy use in the U.S. steel industry: a historical perspective and future opportunities; TOPICAL

    International Nuclear Information System (INIS)

    Stubbles, John

    2000-01-01

    The U.S. steel industry has taken enormous strides over the past decades to reduce its energy consumption; since the end of World War II, the industry has reduced its energy intensity (energy use per shipped ton) by 60 percent. Between 1990 and 1998 alone, intensity has dropped from 20 to 18 million Btu (MBtu) per ton. This figure is projected to decrease to 15 MBtu/ton by 2010 with an asymptotic trend towards 14 MBtu/ton. Domestic shipments are projected to flatten out over the next decade to around 105 million tons which means that total energy consumption will also decrease. Historically, the steel industry has accounted for about 6 percent of U.S. energy consumption. Today, that figure is less than 2 percent and will decrease further to 1.5 percent by 2010. The primary causes for the decrease in energy consumption since WWII are: The use of pellets in the blast furnace and the application of new technology in the ironmaking process to further reduce fuel rates per net ton of hot metal (NTHM); The total replacement of the open hearth process by basic oxygen and electric furnaces; The almost total replacement of ingot casting by continuous casting (which improved yield dramatically and thus reduced the tons of raw steel required per ton of shipments); and The growth of the electric furnace sector of the industry at the expense of hot metal-based processes (which has also stimulated scrap recycling so that about 55 percent of ''new'' steel is now melted from scrap steel). This report focuses on the concept of good practices (i.e., those that are sustainable and can use today's technology). If all the industry could operate on this basis, the additional savings per ton could total 2 MBtu, As further restructuring occurs and the swing from hot metal-based to electric furnace-based production continues, the average consumption will approach the good practice energy per ton. Further savings will accrue through new technology, particularly in the areas of reduced blast

  1. Microbial influences on hormesis, oncogenesis, and therapy: A review of the literature

    International Nuclear Information System (INIS)

    Clanton, Ryan; Saucier, David; Ford, John; Akabani, Gamal

    2015-01-01

    Utilization of environmental stimuli for growth is the main factor contributing to the evolution of prokaryotes and eukaryotes, independently and mutualistically. Epigenetics describes an organism’s ability to vary expression of certain genes based on their environmental stimuli. The diverse degree of dose-dependent responses based on their variances in expressed genetic profiles makes it difficult to ascertain whether hormesis or oncogenesis has or is occurring. In the medical field this is shown where survival curves used in determining radiotherapeutic doses have substantial uncertainties, some as large as 50% (Barendsen, 1990). Many in-vitro radiobiological studies have been limited by not taking into consideration the innate presence of microbes in biological systems, which have either grown symbiotically or pathogenically. Present in-vitro studies neglect to take into consideration the varied responses that commensal and opportunistic pathogens will have when exposed to the same stimuli and how such responses could act as stimuli for their macro/microenvironment. As a result many theories such as radiation carcinogenesis explain microscopic events but fail to describe macroscopic events (Cohen, 1995). As such, this review shows how microorganisms have the ability to perturb risks of cancer and enhance hormesis after irradiation. It will also look at bacterial significance in the microenvironment of the tumor before and during treatment. In addition, bacterial systemic communication after irradiation and the host’s immune responses to infection could explain many of the phenomena associated with bystander effects. Therefore, the present literature review considers the paradigms of hormesis and oncogenesis in order to find a rationale that ties them all together. This relationship was thus characterized to be the microbiome.

  2. Secondary UV radiation from biota as a proof of radiation hormesis and Gurwitsch phenomena

    International Nuclear Information System (INIS)

    Goraczko, W.

    1997-01-01

    High (large) and low (small) doses of ionizing radiation consistently induce opposite physiologic effects in biological systems. The effects of low doses cannot be inferred by interpolation between the result from groups exposed to high doses and controls irradiated only by Natural Background Radiation. Stimulation NBR ('bio-positive') effects by low-level doses of ionizing radiation is called radiation hormesis. It is still a controversial idea; however it was found that some biological objects (yeast, sees, animals) after γ-irradiation by low-level doses (10-50 times more NBR) can increase their development. The results of the researches demonstrate that the excitation of living systems by ionizing radiation (high energy, low doses) produces among other hydrogen peroxide which initiates prolonged secondary emission that can influence biota and activate many important processes in biological systems. On the other hand it is well known that after water irradiation by ionizing radiation as the product of radiolysis concentration of hydrogen peroxide has been received. The spectral analysis of this secondary emission confirmed the contribution of the UV component to the total emission. This secondary radiation can play a very important role in the intercellular communication. The influence of hydrogen peroxide on glycine has been examined. I have measured secondary emission from Gly using the Single Photon Counting device SPC. The data obtained made possible at least a partial understanding of the radiation hormesis phenomenon and suggest closer relationship to mitogenetic radiation. I propose deexcitation processes in biomolecules as a common denominator of UV and ionizing radiation interacting with living cells, underlying both radiation hormesis and mitogenetic effect. Based on the above experiments and other authors' reports it is postulated that low-level doses of ionizing radiation through radiolysis products (among others hydrogen peroxide) generate UV

  3. Transgenerational shifts in reproduction hormesis in green peach aphid exposed to low concentrations of imidacloprid.

    Directory of Open Access Journals (Sweden)

    Murali-Mohan Ayyanath

    Full Text Available Hormesis is a biphasic phenomenon that in toxicology is characterized by low-dose stimulation and high-dose inhibition. It has been observed in a wide range of organisms in response to many chemical stressors, including insects exposed to pesticides, with potential repercussions for agriculture and pest management. To address questions related to the nature of the dose-response and potential consequences on biological fitness, we examined transgenerational hormesis in the green peach aphid, Myzus persicae, when exposed to sublethal concentrations of the insecticide imidacloprid. A hormetic response in the form of increased reproduction was consistently observed and a model previously developed to test for hormesis adequately fit some of our data. However, the nature of the dose-response differed within and across generations depending upon the duration and mode of exposure. Decreased reproduction in intermediate generations confirmed that fitness tradeoffs were a consequence of the hormetic response. However, recovery to levels of reproduction equal to that of controls in subsequent generations and significantly greater total reproduction after four generations suggested that biological fitness was increased by exposure to low concentrations of the insecticide, even when insects were continuously exposed to the stressor. This was especially evident in a greenhouse experiment where the instantaneous rate of population increase almost doubled and total aphid production more than quadrupled when aphids were exposed to potato plants systemically treated with low amounts of imidacloprid. Our results show that although fitness tradeoffs do occur with hormetic responses, this does not necessarily compromise overall biological fitness.

  4. Microbial influences on hormesis, oncogenesis, and therapy: A review of the literature

    Energy Technology Data Exchange (ETDEWEB)

    Clanton, Ryan [Department of Nuclear Engineering, Texas A& M University, College Station, TX 77843 (United States); Texas A& M Institute for Preclinical Studies, Texas A& M University, College Station, TX 77843 (United States); Saucier, David; Ford, John [Department of Nuclear Engineering, Texas A& M University, College Station, TX 77843 (United States); Akabani, Gamal [Department of Nuclear Engineering, Texas A& M University, College Station, TX 77843 (United States); Department of Veterinary Integrative Biosciences, Texas A& M University, College Station, TX 77843 (United States); Texas A& M Institute for Preclinical Studies, Texas A& M University, College Station, TX 77843 (United States)

    2015-10-15

    Utilization of environmental stimuli for growth is the main factor contributing to the evolution of prokaryotes and eukaryotes, independently and mutualistically. Epigenetics describes an organism’s ability to vary expression of certain genes based on their environmental stimuli. The diverse degree of dose-dependent responses based on their variances in expressed genetic profiles makes it difficult to ascertain whether hormesis or oncogenesis has or is occurring. In the medical field this is shown where survival curves used in determining radiotherapeutic doses have substantial uncertainties, some as large as 50% (Barendsen, 1990). Many in-vitro radiobiological studies have been limited by not taking into consideration the innate presence of microbes in biological systems, which have either grown symbiotically or pathogenically. Present in-vitro studies neglect to take into consideration the varied responses that commensal and opportunistic pathogens will have when exposed to the same stimuli and how such responses could act as stimuli for their macro/microenvironment. As a result many theories such as radiation carcinogenesis explain microscopic events but fail to describe macroscopic events (Cohen, 1995). As such, this review shows how microorganisms have the ability to perturb risks of cancer and enhance hormesis after irradiation. It will also look at bacterial significance in the microenvironment of the tumor before and during treatment. In addition, bacterial systemic communication after irradiation and the host’s immune responses to infection could explain many of the phenomena associated with bystander effects. Therefore, the present literature review considers the paradigms of hormesis and oncogenesis in order to find a rationale that ties them all together. This relationship was thus characterized to be the microbiome.

  5. The Adoption of Smoking and Its Effect on the Mortality Gender Gap in Netherlands: A Historical Perspective

    Science.gov (United States)

    Janssen, Fanny; van Poppel, Frans

    2015-01-01

    We examine in depth the effect of differences in the smoking adoption patterns of men and women on the mortality gender gap in Netherlands, employing a historical perspective. Using an indirect estimation technique based on observed lung cancer mortality from 1931 to 2012, we estimated lifetime smoking prevalence and smoking-attributable mortality. We decomposed the sex difference in life expectancy at birth into smoking-related and nonsmoking-related overall and cause-specific mortality. The smoking epidemic in Netherlands, which started among men born around 1850 and among women from birth cohort 1900 onwards, contributed substantially to the increasing sex difference in life expectancy at birth from 1931 (1.3 years) to 1982 (6.7 years), the subsequent decline to 3.7 years in 2012, and the high excess mortality among Dutch men born between 1895 and 1910. Smoking-related cancer mortality contributed most to the increase in the sex difference, whereas smoking-related cardiovascular disease mortality was mainly responsible for the decline from 1983 onwards. Examining nonsmoking-related (cause-specific) mortality shed new light on the mortality gender gap and revealed the important role of smoking-related cancers, the continuation of excess mortality among women aged 40–50, and a smaller role of biological factors in the sex difference than was previously estimated. PMID:26273613

  6. The Adoption of Smoking and Its Effect on the Mortality Gender Gap in Netherlands: A Historical Perspective

    Directory of Open Access Journals (Sweden)

    Fanny Janssen

    2015-01-01

    Full Text Available We examine in depth the effect of differences in the smoking adoption patterns of men and women on the mortality gender gap in Netherlands, employing a historical perspective. Using an indirect estimation technique based on observed lung cancer mortality from 1931 to 2012, we estimated lifetime smoking prevalence and smoking-attributable mortality. We decomposed the sex difference in life expectancy at birth into smoking-related and nonsmoking-related overall and cause-specific mortality. The smoking epidemic in Netherlands, which started among men born around 1850 and among women from birth cohort 1900 onwards, contributed substantially to the increasing sex difference in life expectancy at birth from 1931 (1.3 years to 1982 (6.7 years, the subsequent decline to 3.7 years in 2012, and the high excess mortality among Dutch men born between 1895 and 1910. Smoking-related cancer mortality contributed most to the increase in the sex difference, whereas smoking-related cardiovascular disease mortality was mainly responsible for the decline from 1983 onwards. Examining nonsmoking-related (cause-specific mortality shed new light on the mortality gender gap and revealed the important role of smoking-related cancers, the continuation of excess mortality among women aged 40–50, and a smaller role of biological factors in the sex difference than was previously estimated.

  7. Radiation hormesis of radish using an X-ray photography device

    Energy Technology Data Exchange (ETDEWEB)

    Sakuma, Atsushi [Asahikawa Kousei Hospital, Hokkaido (Japan)

    2000-07-01

    Radiation hormesis was studied at an X-ray photography room. Seed of radish (Kaiwaredaikon) was irradiated by X-ray, from 10 to 3000 mGy. Since the growth of plant was the highest around 500 mGy, 100 seeds were irradiated at a dose of 500 mGy. Fifty seeds were selected and the growth rate was measured after 1 and 2 weeks. After 2 weeks, the growth of the seeds irradiated (129{+-}5 mm) was found to be higher than those without irradiation (115{+-}5 mm). (author)

  8. Mitochondrial Hormesis in Pancreatic β Cells: Does Uncoupling Protein 2 Play a Role?

    Directory of Open Access Journals (Sweden)

    Ning Li

    2012-01-01

    Full Text Available In pancreatic β cells, mitochondrial metabolism translates glucose sensing into signals regulating insulin secretion. Chronic exposure of β cells to excessive nutrients, namely, glucolipotoxicity, impairs β-cell function. This is associated with elevated ROS production from overstimulated mitochondria. Mitochondria are not only the major source of cellular ROS, they are also the primary target of ROS attacks. The mitochondrial uncoupling protein UCP2, even though its uncoupling properties are debated, has been associated with protective functions against ROS toxicity. Hormesis, an adaptive response to cellular stresses, might contribute to the protection against β-cell death, possibly limiting the development of type 2 diabetes. Mitochondrial hormesis, or mitohormesis, is a defense mechanism observed in ROS-induced stress-responses by mitochondria. In β cells, mitochondrial damages induced by sublethal exogenous H2O2 can induce secondary repair and defense mechanisms. In this context, UCP2 is a marker of mitohormesis, being upregulated following stress conditions. When overexpressed in nonstressed naïve cells, UCP2 confers resistance to oxidative stress. Whether treatment with mitohormetic inducers is sufficient to restore or ameliorate secretory function of β cells remains to be determined.

  9. Effect of low-dose ionizing radiation on luminous marine bacteria: radiation hormesis and toxicity

    International Nuclear Information System (INIS)

    Kudryasheva, N.S.; Rozhko, T.V.

    2015-01-01

    The paper summarizes studies of effects of alpha- and beta-emitting radionuclides (americium-241, uranium-235+238, and tritium) on marine microorganisms under conditions of chronic low-dose irradiation in aqueous media. Luminous marine bacteria were chosen as an example of these microorganisms; bioluminescent intensity was used as a tested physiological parameter. Non-linear dose-effect dependence was demonstrated. Three successive stages in the bioluminescent response to americium-241 and tritium were found: 1 – absence of effects (stress recognition), 2 – activation (adaptive response), and 3 – inhibition (suppression of physiological function, i.e. radiation toxicity). The effects were attributed to radiation hormesis phenomenon. Biological role of reactive oxygen species, secondary products of the radioactive decay, is discussed. The study suggests an approach to evaluation of non-toxic and toxic stages under conditions of chronic radioactive exposure. - Highlights: • Luminous bacteria demonstrate nonlinear dose-effect relation in radioactive solutions. • Response to low-dose radiation includes 3 stages: threshold, activation, inhibition. • ROS are responsible for low-dose effects of alpha-emitting radionuclides. • Luminous marine bacteria are a convenient tool to study radiation hormesis

  10. Radiation hormesis: an outcome of exposure to low level ionizing radiation

    International Nuclear Information System (INIS)

    Kant, Krishan

    2012-01-01

    Ionizing radiation is a benign environmental agent at background levels. Human population is always exposed to ionizing radiation from natural sources. Important sources are cosmic rays which come from outer space and from the surface of the sun, terrestrial radionuclides which occur in the earths crust in various geological formations in soils, rocks, building materials, plants, water, food, air and in the human body itself. With the increasing use of radiation in health facilities, scientific research, industry and agriculture, the study of impact of low-level ionizing radiation on environment and possible health effects on future generations has been a cause of concern in recent years. As regards the effects, it is established fact that high doses of ionizing radiation are harmful to health, there exists, however, a substantial controversy regarding the effects of low doses of ionizing radiation (LLIR). In the present paper, brief review of the available literature, data and reports on stimulation by low-dose irradiation and recent data supporting radiation hormesis. A linear quadratic model has been given illustrating the validity of radiation hormesis, besides the comparison of the dose rates arising from natural and manmade sources to the Indian population. This overview summarizes various reports

  11. A Historical Comparative Perspective

    African Journals Online (AJOL)

    MJM Venter

    with the free and fair operation of the financial markets by creating an artificial, false or misleading appearance with respect ... to as the Financial Markets Act. See Benade et al Entrepreneurial Law 130; Van Deventer 2008 ...... Financial Institutions (Protection of Funds) Act 28 of 2001 as amended, hereinafter referred to as.

  12. Diamond films: Historical perspective

    Energy Technology Data Exchange (ETDEWEB)

    Messier, R. [Pennsylvania State Univ., University Park (United States)

    1993-01-01

    This section is a compilation of notes and published international articles about the development of methods of depositing diamond films. Vapor deposition articles are included from American, Russian, and Japanese publications. The international competition to develop new deposition methodologies is stressed. The current status of chemical vapor deposition of diamond is assessed.

  13. Historical perspective of peptidomics

    Directory of Open Access Journals (Sweden)

    Michael Schrader

    2014-06-01

    Full Text Available Peptides have been studied for over 100 years, but for most of this time the focus was on a specific peptide or peptides, and not on the general peptidome of a biological sample. In the 1990s, mass spectrometry techniques were developed for the analysis of proteins, usually after digestion into peptides. The field of peptidomics started soon after proteomics and has grown to over 600 publications that use the word “peptidomic” or “peptidomics”. Although peptidomics is related to proteomics, there are fundamental differences. In this review, we discuss these differences along with the history of the field of peptidomics.

  14. Photon hormesis deactivates alpha-particle induced bystander effects between zebrafish embryos

    International Nuclear Information System (INIS)

    Ng, C.Y.P.; Cheng, S.H.; Yu, K.N.

    2017-01-01

    In the present work, we studied the effects of low-dose X-ray photons on the alpha-particle induced bystander effects between embryos of the zebrafish, Danio rerio. The effects on the naive whole embryos were studied through quantification of apoptotic signals (amounts of cells undergoing apoptosis) at 24 h post fertilization (hpf) using vital dye acridine orange staining, followed by counting the stained cells under a fluorescent microscope. We report data showing that embryos at 5 hpf subjected to a 4.4 mGy alpha-particle irradiation could release a stress signal into the medium, which could induce bystander effect in partnered naive embryos sharing the same medium. We also report that the bystander effect was deactivated when the irradiated embryos were subjected to a concomitant irradiation of 10 or 14 mGy of X-rays, but no such deactivation was achieved if the concomitant X-ray dose dropped to 2.5 or 5 mGy. In the present study, the significant drop in the amount of apoptotic signals on the embryos having received 4.4 mGy alpha particles together X-rays irradiation from 2.5 or 5 mGy to 10 or 14 mGy, together with the deactivation of RIBE with concomitant irradiation of 10 or 14 mGy of X-rays supported the participation of photon hormesis with an onset dose between 5 and 10 mGy, which might lead to removal of aberrant cells through early apoptosis or induction of high-fidelity DNA repair. As we found that photons and alpha particles could have opposite biological effects when these were simultaneously irradiated onto living organisms, these ionizing radiations could be viewed as two different environmental stressors, and the resultant effects could be regarded as multiple stressor effects. The present work presented the first study on a multiple stressor effect which occurred on bystander organisms. In other words, this was a non-targeted multiple stressor effect. The photon hormesis could also explain some failed attempts to observe neutron-induced bystander

  15. The history of nuclear decommissioning: an historical perspective from the view point of the International Atomic Energy Agency

    International Nuclear Information System (INIS)

    Laraia, M.

    2008-01-01

    facilities will reach the end of their operational, lifetime and become candidates for decommissioning. Taking account of work done to date on nuclear facility decommissioning, it is timely to provide an up to date basis for ongoing and foreseen activities in this field. An evaluation of the state of the art, latest trends and current issues is desirable. The approach taken in this paper is to review, from a historical perspective, decommissioning issues either solved in recent years or under way, to assess progress, as well as remaining and new issues. (author)

  16. Effect of low-dose ionizing radiation on luminous marine bacteria: radiation hormesis and toxicity.

    Science.gov (United States)

    Kudryasheva, N S; Rozhko, T V

    2015-04-01

    The paper summarizes studies of effects of alpha- and beta-emitting radionuclides (americium-241, uranium-235+238, and tritium) on marine microorganisms under conditions of chronic low-dose irradiation in aqueous media. Luminous marine bacteria were chosen as an example of these microorganisms; bioluminescent intensity was used as a tested physiological parameter. Non-linear dose-effect dependence was demonstrated. Three successive stages in the bioluminescent response to americium-241 and tritium were found: 1--absence of effects (stress recognition), 2--activation (adaptive response), and 3--inhibition (suppression of physiological function, i.e. radiation toxicity). The effects were attributed to radiation hormesis phenomenon. Biological role of reactive oxygen species, secondary products of the radioactive decay, is discussed. The study suggests an approach to evaluation of non-toxic and toxic stages under conditions of chronic radioactive exposure. Copyright © 2015 Elsevier Ltd. All rights reserved.

  17. What is hormesis and why haven't we heard about it before

    International Nuclear Information System (INIS)

    Sagan, L.A.

    1987-01-01

    Low doses of ionizing radiation are widely believed to produce effects similar to those observed at high doses; only the incidence (i.e. risk) varies with dose. Furthermore, it is assumed that effects other than those observed at high doses will not occur at low doses. Yet there have been frequent reports in the literature of anomalies at low doses--effects unrelated to and unpredictable from the high-dose exposure experiences. These have been referred to as hormetic effects. These effects have their parallel with other hormetic effects seen with many other agents generally considered toxic. It is postulated that hormesis has previously received scant attention because it conflicts with the conventional radiation science paradigm

  18. Establishing cellular stress response profiles as biomarkers of homeodynamics, health, and hormesis

    DEFF Research Database (Denmark)

    Demirovic, Dino; Rattan, Suresh

    2013-01-01

    strategy, which makes use of SRP for achieving healthy aging and extending the healthspan, is that of strengthening the homeodynamics through repeated mild stress-induced hormesis by physical, biological and nutritional hormetins. Furthermore, SRP can also be the basis for defining health as a state......Aging is the progressive shrinkage of the homeodynamic space. A crucial component of the homeodynamic space is the stress response (SR), by virtue of which a living system senses disturbance and initiates a series of events for maintenance, repair, adaptation, remodeling and survival. Here we...... discuss the main intracellular SR pathways in human cells, and argue for the need to define and establish the immediate and delayed stress response profiles (SRP) during aging. Such SRP are required to be established at several age-points, which can be the molecular biomarkers of homeodynamic space...

  19. A list of personal perspectives with selected quotations, along with lists of tributes, historical notes, Nobel and Kettering awards related to photosynthesis.

    Science.gov (United States)

    Krogmann, David W

    2002-01-01

    The history of photosynthesis research can be found in original papers and books. However, a special history is available from the prefatory chapters and the personal perspectives of various researchers who published them in several journals over the last 40 years. We have compiled a list of such perspectives published since 1964. Selection is not easy, especially of authors who were not directly engaged in photosynthesis research; some are included for their special insights related to central issues in the study of photosynthesis. Our journal, Photosynthesis Research, contains other valuable historic data in the occasional tributes, obituaries and historical notes, that have been published. Lists of these items are included. This article ends by listing the Nobel prizes related to photosynthesis and the Kettering Awards for Excellence in Photosynthesis Research. Wherever possible, a web page address is provided. The web page addresses have been taken from the article 'Photosynthesis and the Web: 2001' by Larry Orr and Govindjee, available at http://www.life.uiuc.edu/govindjee/photoweb and at http://photoscience.la.asu.edu/photosyn/ photoweb/default.html.When I find a bit of leisureI trifle with my papers.This is one of the lesserfrailities.'- Horace, Satires I, IV.

  20. Tropical systems from the southwest Indian Ocean making landfall over the Limpopo River Basin, southern Africa: a historical perspective

    CSIR Research Space (South Africa)

    Malherbe, J

    2011-03-01

    Full Text Available The study provides perspective on the contribution of landfalling tropical systems (cyclones, depressions, storms and lows) from the southwest Indian Ocean (SWIO) towards rainfall over the eastern interior of southern Africa, over the period 1948...

  1. A Current Perspective on the Historical Geographic Distribution of the Endangered Muriquis (Brachyteles spp.): Implications for Conservation.

    Science.gov (United States)

    Ingberman, Bianca; Fusco-Costa, Roberto; Monteiro-Filho, Emygdio Leite de Araujo

    2016-01-01

    The muriqui (Brachyteles spp.), endemic to the Atlantic Forest of Brazil, is the largest primate in South America and is endangered, mainly due to habitat loss. Its distribution limits are still uncertain and need to be resolved in order to determine their true conservation status. Species distribution modeling (SDM) has been used to estimate potential species distributions, even when information is incomplete. Here, we developed an environmental suitability model for the two endangered species of muriqui (Brachyteles hypoxanthus and B. arachnoides) using Maxent software. Due to historical absence of muriquis, areas with predicted high habitat suitability yet historically never occupied, were excluded from the predicted historical distribution. Combining that information with the model, it is evident that rivers are potential dispersal barriers for the muriquis. Moreover, although the two species are environmentally separated in a large part of its distribution, there is a potential contact zone where the species apparently do not overlap. This separation might be due to either a physical (i.e., Serra da Mantiqueira mountains) or a biotic barrier (the species exclude one another). Therefore, in addition to environmental characteristics, physical and biotic barriers potentially shaped the limits of the muriqui historical range. Based on these considerations, we proposed the adjustment of their historical distributional limits. Currently only 7.6% of the predicted historical distribution of B. hypoxanthus and 12.9% of B. arachnoides remains forested and able to sustain viable muriqui populations. In addition to measurement of habitat loss we also identified areas for conservation concern where new muriqui populations might be found.

  2. A Current Perspective on the Historical Geographic Distribution of the Endangered Muriquis (Brachyteles spp.: Implications for Conservation.

    Directory of Open Access Journals (Sweden)

    Bianca Ingberman

    Full Text Available The muriqui (Brachyteles spp., endemic to the Atlantic Forest of Brazil, is the largest primate in South America and is endangered, mainly due to habitat loss. Its distribution limits are still uncertain and need to be resolved in order to determine their true conservation status. Species distribution modeling (SDM has been used to estimate potential species distributions, even when information is incomplete. Here, we developed an environmental suitability model for the two endangered species of muriqui (Brachyteles hypoxanthus and B. arachnoides using Maxent software. Due to historical absence of muriquis, areas with predicted high habitat suitability yet historically never occupied, were excluded from the predicted historical distribution. Combining that information with the model, it is evident that rivers are potential dispersal barriers for the muriquis. Moreover, although the two species are environmentally separated in a large part of its distribution, there is a potential contact zone where the species apparently do not overlap. This separation might be due to either a physical (i.e., Serra da Mantiqueira mountains or a biotic barrier (the species exclude one another. Therefore, in addition to environmental characteristics, physical and biotic barriers potentially shaped the limits of the muriqui historical range. Based on these considerations, we proposed the adjustment of their historical distributional limits. Currently only 7.6% of the predicted historical distribution of B. hypoxanthus and 12.9% of B. arachnoides remains forested and able to sustain viable muriqui populations. In addition to measurement of habitat loss we also identified areas for conservation concern where new muriqui populations might be found.

  3. Human Capital or Humane Talent? Rethinking the Nature of Education in China from a Comparative Historical Perspective

    Science.gov (United States)

    Bai, Limin

    2010-01-01

    In order to analyze the impact of human capital theory on contemporary Chinese education, this paper first draws a conceptual outline of how this theory was introduced and interpreted to suit the Chinese quest for modernization. The study then adopts a comparative historical approach to the points of similarity between Neo-Confucian educational…

  4. The "Culture" of Migrant Pupils: A Nation- and Welfare-State Historical Perspective on the European Refugee Crisis

    Science.gov (United States)

    Buchardt, Mette

    2018-01-01

    Culture seems to function as a central explanation when refugees and other migrants are framed as a risk and a challenge in European and national politics across the member states, including educational politics. Based on the case of Denmark during the 1970s, the article unfolds how education historically has been an arena for the internal…

  5. Beyond Progressive Liberalism and Cultural Relativism: Towards Critical Postmodernist, Socio-historically Situated Perspectives in Classroom Studies.

    Science.gov (United States)

    Lin, Angel; Luk, Jasmine

    2002-01-01

    Proposes that classroom studies in the Teaching English as a Second or Other Language (TESOL) field tend to subscribe to either of the following two normative orders: Progressive liberalism or cultural relativism, without reflexively recognizing and meta-analyzing these normative frameworks and their social, historical, and political situatedness.…

  6. Science at Harvard University: Historical Perspectives, edited by Clark A. Elliott and Margaret W. Rossiter. Lehigh University Press, Bethlehem, 1992

    OpenAIRE

    Christenson, Andrew L.

    1992-01-01

    This volume contains historical studies of several sciences as practiced at Harvard University. Two of these studies have relevance to the history of archaeology. A chapter by Toby Appel focuses upon the scientific career of Jeffries Wyman, first curator of Harvard's Peabody Museum. She contrasts Wyman's unassuming character with the dominating personality of his mentor and contemporary Louis Agassiz. Trained as a medi...

  7. Historical consciousness - Contemporary history and the problem of historical perception

    NARCIS (Netherlands)

    Den Hollander, JC

    2002-01-01

    Historical consciousness is an elusive concept, as long as we try to understand it from the narrow perspective of professional historians. Therefore, a wider perspective is needed. If we accept that historical understanding has become a general trait of modern culture, we may try to explain it in

  8. Low dose radiation induced hormesis and its mechanism of free radicals

    International Nuclear Information System (INIS)

    Zhang Liyuan; Huo Hongmei; Zhang Yusong; Zhao Peifeng; Li Wei; Jiang Jiagui

    2008-01-01

    Objective: To investigate whether the supernatant (the stimulating fluid) centrifuged from myeloid cells suspension after low dose radiation in vitro can produce hormesis on the normal or radiation damage cells. The mechanism of free radical was probed. Methods: Mouse myeloid cell suspension was irradiated respectively by 0, 2 and 5 Gy, and cultured in vitro. MTT method was used to measure the reproductive activity of cells. Meanwhile, Cytochrome C reduction method was used to determine the concentration of O 2 - . Lastly, the concentration of O 2 - was decreased or increased by adding DPI or PMA, and the effect of such changes on 'the stimulating fluid' was observed. Results: Co-cultured with 'the stimulating fluid', the reproductive activity of the myeloid cells after large dose radiation or the normal myeloid cells were enhanced. Decreasing the concentration of O 2 - ; may degrade the proliferation of the cells after radiation damage; while increasing it may lead to the opposite result. Conclusions: The stimulating fluid can enhance the proliferation of the myeloid cells after radiation damage and also the normal ones. The mechanism of above-mentioned phenomena might be related with the changes of O 2 - concentration. (authors)

  9. The hormesis effect of plasma-elevated intracellular ROS on HaCaT cells

    Science.gov (United States)

    Szili, Endre J.; Harding, Frances J.; Hong, Sung-Ha; Herrmann, Franziska; Voelcker, Nicolas H.; Short, Robert D.

    2015-12-01

    We have examined the link between ionized-gas plasma delivery of reactive oxygen species (ROS) to immortalized keratinocyte (HaCaT) cells and cell fate, defined in terms of cell viability versus death. Phospholipid vesicles were used as cell mimics to measure the possible intracellular ROS concentration, [ROSi], delivered by various plasma treatments. Cells were exposed to a helium cold atmospheric plasma (CAP) jet for different plasma exposure times (5-60 s) and gas flow rates (50-1000 ml min-1). Based upon the [ROSi] data we argue that plasma-generated ROS in the cell culture medium can readily diffuse into real cells. Plasma exposure that equated to an [ROSi] in the range of 3.81  ×  10-10-9.47  ×  10-8 M, measured at 1 h after the plasma exposure, resulted in increased cell viability at 72 h; whereas a higher [ROSi] at 1 h decreased cell viability after 72 h of culture. This may be because of the manner in which the ROS are delivered by the plasma: HaCaT cells better tolerate a low ROS flux over an extended plasma exposure period of 1 min, compared to a high flux delivered in a few seconds, although the final [ROSi] may be the same. Our results suggest that plasma stimulation of HaCaT cells follows the principle of hormesis.

  10. Inflammatory modulation of exercise salience: using hormesis to return to a healthy lifestyle

    Directory of Open Access Journals (Sweden)

    Bell Jimmy D

    2010-12-01

    Full Text Available Abstract Most of the human population in the western world has access to unlimited calories and leads an increasingly sedentary lifestyle. The propensity to undertake voluntary exercise or indulge in spontaneous physical exercise, which might be termed "exercise salience", is drawing increased scientific attention. Despite its genetic aspects, this complex behaviour is clearly modulated by the environment and influenced by physiological states. Inflammation is often overlooked as one of these conditions even though it is known to induce a state of reduced mobility. Chronic subclinical inflammation is associated with the metabolic syndrome; a largely lifestyle-induced disease which can lead to decreased exercise salience. The result is a vicious cycle that increases oxidative stress and reduces metabolic flexibility and perpetuates the disease state. In contrast, hormetic stimuli can induce an anti-inflammatory phenotype, thereby enhancing exercise salience, leading to greater biological fitness and improved functional longevity. One general consequence of hormesis is upregulation of mitochondrial function and resistance to oxidative stress. Examples of hormetic factors include calorie restriction, extreme environmental temperatures, physical activity and polyphenols. The hormetic modulation of inflammation, and thus, exercise salience, may help to explain the highly heterogeneous expression of voluntary exercise behaviour and therefore body composition phenotypes of humans living in similar obesogenic environments.

  11. The role of the open-quotes stress protein responseclose quotes in hormesis

    International Nuclear Information System (INIS)

    Smith-Sonneborn, J.

    1992-01-01

    Hormesis refers to the phenomenon of induction of beneficial effects by low doses of otherwise harmful physical or chemical agents: 'a little bit of bad can be good for you.' That the hormetic response may operate by a common mechanism has already been proposed, but this review is the first to propose the hypothesis that the common pathway is a heat shock-like response. The heat shock response is a model for a more general phenomenon, called the stress response. The stress response is characterized by increased synthesis of a family of stressor specific proteins with concomitant reduction of synthesis of most of the proteins transcribed prior to the exposure to the toxic agent. The stress response has been characterized using heat, radiation, heavy metals, and oxidizing agents as the stressors. This chapter includes: Identification of agents known to induce both the stress response and hormetic phenomena; A description of the unique and common pathways in the stress response to three stressors - heat, DNA-damaging agents, and teratogens; The stress response as a model for teratogen-induced damage; A theory explaining the paradoxical beneficial response to low doses of an otherwise harmful agent via a stress-response pathway

  12. Extension of lifespan in C. elegans by naphthoquinones that act through stress hormesis mechanisms.

    Directory of Open Access Journals (Sweden)

    Piper R Hunt

    Full Text Available Hormesis occurs when a low level stress elicits adaptive beneficial responses that protect against subsequent exposure to severe stress. Recent findings suggest that mild oxidative and thermal stress can extend lifespan by hormetic mechanisms. Here we show that the botanical pesticide plumbagin, while toxic to C. elegans nematodes at high doses, extends lifespan at low doses. Because plumbagin is a naphthoquinone that can generate free radicals in vivo, we investigated whether it extends lifespan by activating an adaptive cellular stress response pathway. The C. elegans cap'n'collar (CNC transcription factor, SKN-1, mediates protective responses to oxidative stress. Genetic analysis showed that skn-1 activity is required for lifespan extension by low-dose plumbagin in C. elegans. Further screening of a series of plumbagin analogs identified three additional naphthoquinones that could induce SKN-1 targets in C. elegans. Naphthazarin showed skn-1dependent lifespan extension, over an extended dose range compared to plumbagin, while the other naphthoquinones, oxoline and menadione, had differing effects on C. elegans survival and failed to activate ARE reporter expression in cultured mammalian cells. Our findings reveal the potential for low doses of naturally occurring naphthoquinones to extend lifespan by engaging a specific adaptive cellular stress response pathway.

  13. Pest insect olfaction in an insecticide-contaminated environment: info-disruption or hormesis effect.

    Science.gov (United States)

    Tricoire-Leignel, Hélène; Thany, Steeve Hervé; Gadenne, Christophe; Anton, Sylvia

    2012-01-01

    Most animals, including pest insects, live in an "odor world" and depend strongly on chemical stimuli to get information on their biotic and abiotic environment. Although integrated pest management strategies including the use of insect growth regulators (IGRs) are increasingly developed, most insect pest treatments rely on neurotoxic chemicals. These molecules are known to disrupt synaptic transmission, affecting therefore sensory systems. The wide-spread use of neurotoxic insecticides and the growing use of IGRs result in residual accumulation of low concentrations in the environment. These insecticide residues could act as an "info-disruptor" by modifying the chemical communication system, and therefore decrease chances of reproduction in target insects. However, residues can also induce a non-expected hormesis effect by enhancing reproduction abilities. Low insecticide doses might thus induce adaptive processes in the olfactory pathway of target insects, favoring the development of resistance. The effect of sublethal doses of insecticides has mainly been studied in beneficial insects such as honeybees. We review here what is known on the effects of sublethal doses of insecticides on the olfactory system of insect pests.

  14. Complex mixture-associated hormesis and toxicity: the case of leather tanning industry.

    Science.gov (United States)

    Pagano, Giovanni; Castello, Giuseppe; Gallo, Marialuisa; Borriello, Ilaria; Guida, Marco

    2008-01-01

    A series of studies investigated the toxicities of tannery-derived complex mixtures, i.e. vegetable tannin (VT) from Acacia sp. or phenol-based synthetic tannin (ST), and waste-water from tannin-based vs. chromium-based tanneries. Toxicity was evaluated by multiple bioassays including developmental defects and loss of fertilization rate in sea urchin embryos and sperm (Paracentrotus lividus and Sphaerechinus granularis), and algal growth inhibition (Dunaliella tertiolecta and Selenastrum capricornutum). Both VT and ST water extracts resulted in hormetic effects at concentrations ranging 0.1 to 0.3%, and toxicity at levels > or =1%, both in sea urchin embryo and sperm, and in algal growth bioassays. When comparing tannin-based tannery wastewater (TTW) vs. chromium-based tannery effluent (CTE), a hormesis to toxicity trend was observed for TTW both in terms of developmental and fertilization toxicity in sea urchins, and in algal growth inhibition, with hormetic effects at 0.1 to 0.2% TTW, and toxicity at TTW levels > or =1%. Unlike TTW, CTE showed a monotonic toxicity increase from the lowest tested level (0.1%) and CTE toxicity at higher levels was significantly more severe than TTW-induced toxicity. The results support the view that leather production utilizing tannins might be regarded as a more environmentally friendly procedure than chromium-based tanning process.

  15. Nuclear energy and health: and the benefits of low-dose radiation hormesis.

    Science.gov (United States)

    Cuttler, Jerry M; Pollycove, Myron

    2009-01-01

    Energy needs worldwide are expected to increase for the foreseeable future, but fuel supplies are limited. Nuclear reactors could supply much of the energy demand in a safe, sustainable manner were it not for fear of potential releases of radioactivity. Such releases would likely deliver a low dose or dose rate of radiation, within the range of naturally occurring radiation, to which life is already accustomed. The key areas of concern are discussed. Studies of actual health effects, especially thyroid cancers, following exposures are assessed. Radiation hormesis is explained, pointing out that beneficial effects are expected following a low dose or dose rate because protective responses against stresses are stimulated. The notions that no amount of radiation is small enough to be harmless and that a nuclear accident could kill hundreds of thousands are challenged in light of experience: more than a century with radiation and six decades with reactors. If nuclear energy is to play a significant role in meeting future needs, regulatory authorities must examine the scientific evidence and communicate the real health effects of nuclear radiation. Negative images and implications of health risks derived by unscientific extrapolations of harmful effects of high doses must be dispelled.

  16. Sublethal and hormesis effects of imidacloprid on the soybean aphid Aphis glycines.

    Science.gov (United States)

    Qu, Yanyan; Xiao, Da; Li, Jinyu; Chen, Zhou; Biondi, Antonio; Desneux, Nicolas; Gao, Xiwu; Song, Dunlun

    2015-04-01

    The soybean aphid, Aphis glycines Matsumura, is a major pest in soybean crop. Current management of this pest relies mainly on insecticides applications, and the neonicotinoid imidacloprid has been proposed as an effective insecticide to control A. glycines in soybean field. Imidacloprid at lethal concentrations not only exerts acute toxicity to A. glycines, but also cause various biological changes when aphids are chronically exposed to lower concentrations. In this study, we assessed the effects of a low-lethal (0.20 mg L(-1)) and two sublethal (0.05 and 0.10 mg L(-1)) imidacloprid concentrations on various A. glycines life history traits. Aphid exposure to 0.20 mg L(-1) imidacloprid caused slower juvenile development, shorter reproductive period, and reduced adult longevity, fecundity and total lifespan. Stimulatory effects, i.e. hormesis, on reproduction and immature development duration were observed in aphids exposed to the lower sublethal imidacloprid concentrations. Consequently, the net reproduction rate (R 0) was significantly higher than in the control aphids. These findings stress the importance of the actual imidacloprid concentration in its toxicological properties on A. glycines. Therefore, our results would be useful for assessing the overall effects of imidacloprid on A. glycines and for optimizing integrated pest management programs targeting this pest.

  17. Commentary on resveratrol and hormesis: resveratrol--a hormetic marvel in waiting?

    Science.gov (United States)

    Marques, Francine Z; Morris, Brian J

    2010-12-01

    Hormesis is a phenomenon in which adaptive responses to low doses of otherwise-harmful factors (also called mild stressors) make cells and organisms more robust. In their review, Calabrese et al. provide evidence for resveratrol acting hormetically in different types of human cell lines. The effects of resveratrol represent a 'two-edged sword' in that it has contrasting effects at low and high doses in healthy and cancerogenous cells. What demarcates a low and a high dose needs to be clarified. Concentrations tested in cell cultures, moreover, may not be relevant to whole organisms. And data from animal models need not apply to humans. Co-morbidities should also be considered. More research is needed to understand the action of resveratrol on all cell types and conditions, and the optimum therapeutic concentration that applies to each of these. Future research needs to determine the dynamics of the effects of resveratrol in different subcellular compartments and the interactions of these. In addition, the interactions between resveratrol, environmental factors, other compounds and medications, diseases and the genetic background of the individual will need to be appreciated in order to gain a complete understanding of the hormetic response of resveratrol.

  18. Pest insect olfaction in an insecticide-contaminated environment : info-disruption or hormesis effect

    Directory of Open Access Journals (Sweden)

    Hélène eTricoire-Leignel

    2012-03-01

    Full Text Available Most animals, including pest insects, live in an odour world and depend strongly on chemical stimuli to get information on their biotic and abiotic environment. Although integrated pest management strategies including the use of insect growth regulators (IGRs are increasingly developed, most insect pest treatments rely on neurotoxic chemicals. These molecules are known to disrupt synaptic transmission, affecting therefore sensory systems. The wide-spread use of neurotoxic insecticides and the growing use of IGRs result in residual accumulation of low concentrations in the environment. These insecticide residues could act as an info-disruptor by modifying the chemical communication system, and therefore decrease chances of reproduction in target insects. However, residues can also induce a non-expected hormesis effect by enhancing reproduction abilities. Low insecticide doses might thus induce adaptive processes in the olfactory pathway of target insects, favouring the development of resistance. The effect of sublethal doses of insecticides has mainly been studied in beneficial insects such as honeybees. We review here what is known on the effects of sublethal doses of insecticides on the olfactory system of insect pests.

  19. Natural oxygenation of Champagne wine during ageing on lees: A metabolomics picture of hormesis.

    Science.gov (United States)

    Roullier-Gall, Chloé; Witting, Michael; Moritz, Franco; Gil, Ryan B; Goffette, Delphine; Valade, Michel; Schmitt-Kopplin, Philippe; Gougeon, Régis D

    2016-07-15

    The oxygenation of Champagne wine after 4 and 6 years of aging on lees in bottle was investigated by FTICR-MS and UPLC-Q-TOF-MS. Three levels of permeability were considered for the stoppers, ranging from 0.2 to 1.8 mg/L/year of oxygen transfer rate. Our results confirmed a good repeatability of ultra-high resolution FTICR-MS, both in terms of m/z and coefficient of variation of peak intensities among biological replicates. Vintages appeared to be the most discriminated features, and metabolite annotations suggested that the oldest wines (2006) were characterized by a higher sensitivity towards oxygenation. Within each vintage, the oxygenation mechanisms appeared to be different for low and high ingresses of oxygen, in agreement with the hormesis character of wine oxygenation. In the particular case of single variety wines and for a given level of stopper permeability, our results also showed that variety discrimination could be easily achieved among wines. Copyright © 2016 Elsevier Ltd. All rights reserved.

  20. Separation – integration – and now …? - An historical perspective on the relationship between German management accounting and financial accounting

    OpenAIRE

    Brandau, M.; Endenich, C.; Luther, R.; Trapp, R.

    2017-01-01

    German accounting has traditionally followed a dual ledger approach with strictly separated internal cost accounting, as the basis for management information, and external financial accounting focusing on creditor protection and based on the commercial law. However, the increased adoption of integrated accounting system implies a significant change in the relationship between financial and management accounting systems. We use Hegelian dialectic to trace the historical development of German a...

  1. Historical Perspectives: A Review and Evaluation of 76 Studies of the Defense Research Enterprise, 1945-2015

    Science.gov (United States)

    2016-08-01

    support and contractor oversight. Recommendations Administration / Organizational Structure  SECDEF and CJCS should initiate high -level “Packard...relevant historical detail, and prominent policy tensions are emphasized. Views expressed in summaries and evaluations represent only those of the...capabilities; 2) Supporting the DoD Smart Buyer mission throughout the acquisition lifecycle (i.e. “the ability to collaborate with contractors and assess

  2. Two items: Transcription of a presentation by Dr. E. L. Albenesius, ''SRS burial ground operation from an historical perspective''; video tape entitled ''Burial ground operation''

    International Nuclear Information System (INIS)

    Holcomb, H.P.

    1992-01-01

    On February 6, 1992, approximately 35 SRS personnel from DOE, WSRC, and Dames and Moore attended a very informative talk given by Dr. E.L. Albenesius who discussed the operation of the SRS Burial Ground from an historical perspective. Dr. Albenesius, a Du Point retiree, formerly served as research manager of SRL's Environmental Effects and Solid Waste Management Technology Divisions among other assignments. One notable point Dr. Albenesius made was in answer to a question concerning what was the most important thing that could be done to reduce the hazard to man from buried waste. His response was to remove as much plutonium as practical prior to closure. In order to preserve this valuable information for the record, the program was audiotaped from which a point-by-point chronological transcription, with minor editing, was prepared

  3. Developments of high physiological function technique for vegetable and flower nursery trees using radiation hormesis and chemical analysis of the physiological function using radiation isotopes

    International Nuclear Information System (INIS)

    Honda, I.; Hamano, M.; Yamazaki, H.

    2004-01-01

    A large number of young lettuces were irradiated by carbon ion and neon ion for searching the effects of heavy ion doses. The irradiated young lettuces were grown up normally on the dose of 100 Gy. Sprouting tests of lettuce seed were carried out by irradiation dose of <30 Gy for research of hormesis effect. The sprouting rate of irradiated lettuce seeds at temperature 30 degC increased at dose of 0.3 Gy for carbon ion, and at dose of 0.1 Gy for neon ion, in comparison with the one of non-treated seeds. The sprouting test at 35 degC were carried out, also. An initial sprouting promotion effect, the hormesis effect was suggested at low dose of the heavy ions. Possibility of technical application aiming at hormesis effects for creating mutant should be investigated on heavy ion beam irradiation also, as well as the gamma-ray irradiation. (M. Suetake)

  4. Historical perspectives on autism: its past record of discovery and its present state of solipsism, skepticism, and sorrowful suspicion.

    Science.gov (United States)

    Greydanus, Donald E; Toledo-Pereyra, Luis H

    2012-02-01

    Concepts of autism have evolved over the twentieth century after Bleuler coined the term to refer to symptoms of self-absorption in those with schizophrenia. Autism nosology changed to the current sesquipedalian constellation of autism spectrum disorders with a confusing archipelago of 5 conditions that often serve as islands of confusion to both the general public and professionals. This article reviews historical links that have led to the current confusing and controversial situation that is encouraging some people to return to magic, mysticism, and mantics for health care, despite the amazing accumulation of progress in vaccinology over the past 2 centuries. Copyright © 2012 Elsevier Inc. All rights reserved.

  5. Radioactive waste storage: historical outlook and socio technical analysis; Le stockage des dechets radioactifs: perspective historique et analyse sociotechnique

    Energy Technology Data Exchange (ETDEWEB)

    Petit, J C

    1993-07-01

    The radioactive waste storage remains, in most of the industrialized concerned countries, one extremely debated question. This problem may, if an acceptable socially answer is not found, to create obstacles to the whole nuclear path. This study aim was to analyze the controversy in an historical outlook. The large technological plans have always economical, political, sociological, psychological and so on aspects, that the experts may be inclined to neglect. ``Escape of radioactivity is unlikely, as long as surveillance of the waste is maintained, that is, as long as someone is present to check for leaks or corrosion or malfunctioning of and to take action, if any of these occur. 444 refs., 32 figs.

  6. East is East and West is West - a literary and historical view from the perspective of Madame Butterfly

    OpenAIRE

    Bamford, Nick

    2016-01-01

    In this paper I will look at aspects of cultural difference as well as commercial and political relationships between East and West in a literary and historical context. These aspects have become evident during research for my PhD by practice, which involves creating a contemporary, gay, screen adaptation of the story of Madame Butterfly. I will demonstrate how the story, by American author John Luther Long, emerged in response to the fashion of ‘Japonisme’, which was prompted by the opening ...

  7. A historical perspective on the development of modern concepts of tissue perfusion: prehistory to the twentieth century.

    Science.gov (United States)

    Ashby, Nathan; Squiers, Joshua

    2014-09-01

    The historical development of the concept of perfusion is traced, with particular focus on the development of the modern clinical concepts of perfusion through the fields of anatomy, physiology, and biochemistry. This article reviews many of the significant contributors to the changing ideas of perfusion up through the twentieth century that have influenced the modern physiologic circulatory and metabolic models. The developments outlined have provided the modern model of perfusion, linking the cardiopulmonary circulation, tissue oxygen utilization and carbon dioxide production, food intake, tissue waste production and elimination, and ultimately the production and utilization of ATP in the body. Copyright © 2014 Elsevier Inc. All rights reserved.

  8. Chlorpyrifos-induced hormesis in insecticide-resistant and -susceptible Plutella xylostella under normal and high temperatures.

    Science.gov (United States)

    Deng, Z Z; Zhang, F; Wu, Z L; Yu, Z Y; Wu, G

    2016-06-01

    Hormesis induced by insecticides at the dosage lower than what ostensibly directly causes death on insects was studied. This paper reports the effects of the in vivo application of varied concentrations of chlorpyrifos (CPF) on Plutella xylostella (DBM). The insecticide concentrations applied included 0.000025-2.5 mg l-1, which are far lower than LC1 (7.2 mg l-1), for the CPF-susceptable (Si) DBM, and 250 mg l-1 which is far below LC1 (1286 mg l-1), for the CPF-resistant (Rc) DBM, as well as LC10- and LC50-doses for both strains. Significant hormesis was found with the 'hermetic-CPFs', i.e., 0.0025 mg l-1 for Si DBM and 2.5 mg l-1 for Rc DBM, at the normal or high temperature either in a 24 h or under a long-term treatment. These doses of CPF significantly stimulated the development and increased the fecundity of Si and Rc DBM at 25°C with approximately 23.5-29.8% activity increase on acetylcholinesterase (AChE) and 30.5-91.3% increase on glutathione S-transferases (GSTs) at 25 or 38°C in 4-24 h. The enzymatic activities were significantly reduced by LC50-CPF at 25°C in vivo, but the inhibition was relieved significantly, if the insects were first subjected to a hormetic-CPF pretreatment. It was remarkable that the average rates of enzymatic activity increase were 67.5-76.6% for AChE and 366-546% for GSTs. Consequently, it was concluded that the hormesis on Si and Rc DBM could be induced by CPF doses far below LC1 at normal or high temperature in short- or long-term treatment. These findings might help to improve the current insect control practices in the field.

  9. The hormetic zone: an ecological and evolutionary perspective based upon habitat characteristics and fitness selection.

    Science.gov (United States)

    Parsons, P A

    2001-12-01

    Fitness varies nonlinearly with environmental variables such as temperature, water availability, and nutrition, with maximum fitness at intermediate levels between more stressful extremes. For environmental agents that are highly toxic at exposures that substantially exceed background levels, fitness is maximized at concentrations near zero--a phenomenon often referred to as hormesis. Two main components are suggested: (1) background hormesis, which derives from the direct adaptation of organisms to their habitats; and (2) stress-derived hormonesis, which derives from metabolic reserves that are maintained as an adaptation to environmental stresses through evolutionary time. These reserves provide protection from lesser correlated stresses. This article discusses illustrative examples, including ethanol and ionizing radiation, aimed at placing hormesis into an ecological and evolutionary context. A unifying approach comes from fitness-stress continua that underlie responses to abiotic variables, whereby selection for maximum metabolic efficiency and hence fitness in adaptation to habitats in nature underlies hormetic zones. Within this reductionist model, more specific metabolic mechanisms to explain hormesis are beginning to emerge, depending upon the agent and the taxon in question. Some limited research possibilities based upon this evolutionary perspective are indicated.

  10. Historical perspectives on channel pattern in the Clark Fork River, Montana and implications for post-dam removal restoration

    Science.gov (United States)

    Woelfle-Erskine, C. A.; Wilcox, A. C.

    2009-12-01

    Active restoration approaches such as channel reconstruction have moved beyond the realm of small streams and are being applied to larger rivers. Uncertainties arising from limited knowledge, fluvial and ecosystem variability, and contaminants are especially significant in restoration of large rivers, where project costs and the social, infrastructural, and ecological costs of failure are high. We use the case of Milltown Dam removal on the Clark Fork River, Montana and subsequent channel reconstruction in the former reservoir to examine the use of historical research and uncertainty analysis in river restoration. At a cost of approximately $120 million, the Milltown Dam removal involves the mechanical removal of approximately 2 million cubic meters of sediments contaminated by upstream mining, followed by restoration of the former reservoir reach in which a single-thread meandering channel is being constructed. Historical maps, surveys, photographs, and accounts suggest a conceptual model of a multi-thread, anastomosing river in the reach targeted for channel reconstruction, upstream of the confluence of the Clark Fork and Blackfoot Rivers. We supplemented historical research with analysis of aerial photographs, topographic data, and USGS stage-discharge measurements in a lotic but reservoir-influenced reach of the Clark Fork River within our study area to estimate avulsion frequency (0.8 avulsions/year over a 70-year period) and average rates of lateral migration and aggradation. These were used to calculate the mobility number, a dimensionless relationship between channel filling and lateral migration timescales that can be used to predict whether a river’s planform is single or multi-threaded. The mobility number within our study reach ranged from 0.6 (multi-thread channel) to 1.7 (transitional channel). We predict that, in the absence of active channel reconstruction, the post-dam channel pattern would evolve to one that alternates between single and multi

  11. Historical and Physical Account on Entropy and Perspectives on the Second Law of Thermodynamics for Astrophysical and Cosmological Systems

    Directory of Open Access Journals (Sweden)

    Jeroen Schoenmaker

    2014-08-01

    Full Text Available We performed an in depth analysis of the subjects of entropy and the second law of thermodynamics and how they are treated in astrophysical systems. These subjects are retraced historically from the early works on thermodynamics to the modern statistical mechanical approach and analyzed in view of specific practices within the field of astrophysics. As often happens in discussions regarding cosmology, the implications of this analysis range from physics to philosophy of science. We argue that the difficult question regarding entropy and the second law in the scope of cosmology is a consequence of the dominating paradigm. We further demonstrate this point by assuming an alternative paradigm, not related to thermodynamics of horizons, and successfully describing entropic behavior of astrophysical systems.

  12. The Role of Stigma and Denormalization in Suicide-Prevention Laws in East Asia: A Sociocultural, Historical, and Ethical Perspective.

    Science.gov (United States)

    Chen, Justin A; Courtwright, Andrew; Wu, Kevin Chien-Chang

    In many Western countries, the criminalization and stigmatization of suicide has given way to a biomedical approach aimed at destigmatizing suicide and treating underlying mental illness. By contrast, in many East Asian countries, suicide has never historically been criminalized or stigmatized. High rates of suicide in Japan, South Korea, and Taiwan have recently led policy makers in those countries to pursue innovative suicide-prevention strategies. The intentional denormalization of harmful behaviors has been discussed in the public health and ethics literatures, particularly with regard to smoking cessation, and could represent a novel mechanism for preventing suicides in East Asia. Using examples from the sociocultural, historical, and legal discourses surrounding suicide in Western and East Asian contexts, we suggest that denormalization can be a justified, culturally relevant suicide-prevention strategy, but that care must be taken to avoid shaming or stigmatizing suicidal individuals. Specifically, we propose the term weak denormalization to refer to an ethically permissible strategy at the mildest end of a spectrum of denormalizing approaches-milder than the reintegrative shaming described in the criminal justice literature, and diametrically opposed to outright stigmatization, which is generally considered ethically impermissible. Given the severe stigma of mental illness in East Asia, adopting the dominant Western view of suicide as solely a psychiatric concern would not be justified. Weak denormalization strategies in East Asia should be culturally tailored and rigorously tested on a small scale. They should include social supports, praise for the bravery of those of who seek help, and strategies to reduce shame regarding perceived social failure.

  13. A biased historical perspective of women in the engineering field at Dryden from 1946 to November 1992

    Science.gov (United States)

    Powers, Sheryll Goecke

    1994-01-01

    Being a woman in engineering, and in particular, being the woman with the dubious distinction of having the most years at Dryden, gives the author a long-term perspective on the women who worked in the engineering field and their working environment. The working environment for the women was influenced by two main factors. One factor was the Dryden's growth of 14 persons (2 of them women) at the end of 1946 to the present size. The other factor was the need for programming knowledge when the digital computers came into use. Women have been involved with flight research at Dryden since the days of the first transonic and supersonic airplanes. This paper uses available records, along with memory, to document the number of women in engineering at Dryden, to comment about observed trends, and to make personal observations.

  14. Mobile phone signal exposure triggers a hormesis-like effect in Atm+/+ and Atm-/- mouse embryonic fibroblasts.

    Science.gov (United States)

    Sun, Chuan; Wei, Xiaoxia; Fei, Yue; Su, Liling; Zhao, Xinyuan; Chen, Guangdi; Xu, Zhengping

    2016-11-18

    Radiofrequency electromagnetic fields (RF-EMFs) have been classified by the International Agency for Research on Cancer as possible carcinogens to humans; however, this conclusion is based on limited epidemiological findings and lacks solid support from experimental studies. In particular, there are no consistent data regarding the genotoxicity of RF-EMFs. Ataxia telangiectasia mutated (ATM) is recognised as a chief guardian of genomic stability. To address the debate on whether RF-EMFs are genotoxic, we compared the effects of 1,800 MHz RF-EMF exposure on genomic DNA in mouse embryonic fibroblasts (MEFs) with proficient (Atm +/+ ) or deficient (Atm -/- ) ATM. In Atm +/+ MEFs, RF-EMF exposure for 1 h at an average special absorption rate of 4.0 W/kg induced significant DNA single-strand breaks (SSBs) and activated the SSB repair mechanism. This effect reduced the DNA damage to less than that of the background level after 36 hours of exposure. In the Atm -/- MEFs, the same RF-EMF exposure for 12 h induced both SSBs and double-strand breaks and activated the two repair processes, which also reduced the DNA damage to less than the control level after prolonged exposure. The observed phenomenon is similar to the hormesis of a toxic substance at a low dose. To the best of our knowledge, this study is the first to report a hormesis-like effect of an RF-EMF.

  15. Adaptation to acrolein through upregulating the protection by glutathione in human bronchial epithelial cells: the materialization of the hormesis concept.

    Science.gov (United States)

    Sthijns, Mireille M J P E; Randall, Matthew J; Bast, Aalt; Haenen, Guido R M M

    2014-04-18

    Acrolein is a thiol reactive compound present in cigarette smoke and plays a pivotal role in the deleterious effects of smoking. Acrolein causes toxicity in human bronchial epithelial cells in a dose dependent manner. GSH forms the first line of defense against acrolein-induced toxicity. At high doses of acrolein (⩾10 μM) the capacity of the cellular protection by GSH is overwhelmed and GSH is not able to quench all the acrolein, resulting in cytotoxicity. At a relatively low dose of acrolein (3 μM), no cytotoxicity is observed due to protection by GSH. Moreover we found that exposure to a low dose of acrolein protects cells against the toxic effect of a second higher dose of acrolein. The adaptation to acrolein is induced via Nrf2 mediated gene expression of γ-glutamylcysteine synthetase leading to elevated GSH levels. This upregulation of the protection by GSH demonstrates a hormetic response to acrolein. Hormesis is an adaptive or compensatory response induced by a relatively subtle challenge of homeostasis by a toxic compound. Insight into the mechanism of hormesis is mandatory for a more accurate societal regulation of toxic compounds. Copyright © 2014 Elsevier Inc. All rights reserved.

  16. Rise, fall and resurrection of chromosome territories: a historical perspective. Part I. The rise of chromosome territories

    Directory of Open Access Journals (Sweden)

    T Cremer

    2009-06-01

    Full Text Available It is now generally accepted that chromosomes in the cell nucleus are organized in distinct domains, first called chromosome territories in 1909 by the great cytologist Theodor Boveri. Yet, even today chromosomes have remained enigmatic individuals, whose structures, arrangements and functions in cycling and post-mitotic cells still need to be explored in full detail. Whereas numerous recent reviews describe present evidence for a dynamic architecture of chromosome territories and discuss the potential significance within the functional compartmentalization of the nucleus, a comprehensive historical account of this important concept of nuclear organization was lacking so far. Here, we describe the early rise of chromosome territories within the context of the discovery of chromosomes and their fundamental role in heredity, covering a period from the 1870th to the early 20th century (part I, this volume. In part II (next volume we review the abandonment of the chromosome territory concept during the 1950th to 1980th and the compelling evidence, which led to its resurrection during the 1970th to 1980th.

  17. China's People-to-people Diplomacy and Its Importance to China-EU Relations: A Historical Institutionalism Perspective

    Directory of Open Access Journals (Sweden)

    Shichen Wang

    2015-12-01

    Full Text Available People-to-people exchange has become a heated topic of the Chinese foreign policy. Since the beginning of the twenty-first century, China has established people-to-people dialogues with the United States, the European Union, the United Kingdom, France and Russia. In 2012, China and the EU established a high-level dialogue for people-to-people exchange, making people-to-people exchange the third pillar of China-EU relations. However, China is not a newcomer to people-to-people exchanges with Europe. Why does China launch the people-to-people diplomacy? Is it a plus or a must for China as well as for China-EU relations? The author reviews the history and current situation of China's people-to-people exchange and investigates China’s motivations behind the policy. Using the historical institutionalism as an approach, this paper argues that people-to-people diplomacy is a key component of the contemporary Chinese foreign policy towards Europe. China has long been an unequal counterpart to Europe since the 1840s. After the development of bilateral political and economic cooperation in the past four decades, people-to-people diplomacy is the last part that China needs to finish in order to regain equal status with Europe. In addition, it is also a step towards realising the "great rejuvenation of the Chinese nation".

  18. A cultural historical activity theory perspective to understand preservice science teachers' reflections on and tensions during a microteaching experience

    Science.gov (United States)

    Sezen-Barrie, Asli; Tran, Minh-Dan; McDonald, Scott P.; Kelly, Gregory J.

    2014-09-01

    This study draws from cultural historical activity theory (CHAT) to analyze preservice teachers' reflections on a microteaching activity. Microteaching activities involved preservice educators teaching middle school students from local schools. The study was conducted with 23 preservice teachers enrolled in a large university's teacher education program. During this secondary science teaching methods course, every pair of preservice teachers engaged in 20 minute microteaching activity with 3-5 middle school students. The microteaching was videotaped, and the teachers subsequently provided voice-over reflections on a second audio track. Transcriptions of the microteaching events were analyzed through the formation of event maps showing the phases of activity and the organizational sequence of actions. Event maps were used to investigate the focus of preservice teachers' reflections. The results showed that while learning from their microteaching, preservice teachers focused primarily on the mediating artifacts and gave least attention to the larger teaching community surrounding these activities. Use of CHAT helped to identify challenges in different elements of the microteaching activity. The study contributes to how reflective practice can be enhanced through attention to the social and cultural dimensions of the teaching.

  19. Science at Harvard University: Historical Perspectives, edited by Clark A. Elliott and Margaret W. Rossiter. Lehigh University Press, Bethlehem, 1992

    Directory of Open Access Journals (Sweden)

    Andrew L. Christenson

    1992-05-01

    Full Text Available This volume contains historical studies of several sciences as practiced at Harvard University. Two of these studies have relevance to the history of archaeology. A chapter by Toby Appel focuses upon the scientific career of Jeffries Wyman, first curator of Harvard's Peabody Museum. She contrasts Wyman's unassuming character with the dominating personality of his mentor and contemporary Louis Agassiz. Trained as a medical doctor, Wyman's main love was zoology, particularly comparative anatomy. In his mid-40s, he encountered his first shell midden and was bitten by the archaeology bug. Soon he was doing pioneering excavation in both New England and Florida. In 1866, he was selected to be the curator of the Peabody Museum, primarily upon his strong museum background but also because of the high regard with which he was held by certain influential people. His selection to this position may have made him America's first professional archaeologist. His principal responsibilities were to collect and display archaeological and ethnological specimens and he made great steps in this direction prior to his death in 1874. Wyman's scientific work was poorly known or studied (he is best noted for having made the first scientific description of the gorilla, in part, Appel argues, because he did not seek acclaim or controversy. His greatest influence was locally through personal interactions with students and colleagues. His archaeological work is only briefly discussed in this and the following article, and there is still much to be written about this man of high character.

  20. Hyperoxia exposure induced hormesis decreases mitochondrial superoxide radical levels via Ins/IGF-1 signaling pathway in a long-lived age-1 mutant of Caenorhabditis elegans

    International Nuclear Information System (INIS)

    Yanase, Sumino; Ishii, Naoaki

    2008-01-01

    The hormetic effect, which extends the lifespan by various stressors, has been confirmed in Caenorhabditis elegans (C. elegans). We have previously reported that oxidative stress resistance in a long-lived mutant age-1 is associated with the hormesis. In the age-1 allele, which activates an insulin/insulin-like growth factor-1 (Ins/IGF-1) signaling pathway, the superoxide dismutase (SOD) and catalase activities increased during normal aging. We now demonstrate changes in the mitochondrial superoxide radical (O 2 - ) levels of the hormetic conditioned age-related strains. The O 2 - levels in age-1 strain significantly decreased after intermittent hyperoxia exposure. On the other hand, this phenomenon was not observed in a daf-16 null mutant. This hormesis-dependent reduction of the O 2 - levels was observed even if the mitochondrial Mn-SOD was experimentally reduced. Therefore, it is indicated that the hormesis is mediated by events that suppress the mitochondrial O 2 - production. Moreover, some SOD gene expressions in the hormetic conditioned age-1 mutant were induced over steady state messenger ribonucleic acid (mRNA) levels. These data suggest that oxidative stress-inducible hormesis is associated with a reduction of the mitochondrial O 2 - production by activation of the antioxidant system via the Ins/IGF-1 signaling pathway. (author)

  1. Radioactive iodine (131I) therapy for differentiated thyroid cancer in Japan. Current issues with historical review and future perspective

    International Nuclear Information System (INIS)

    Higashi, Tatsuya; Kudo, Takashi; Kinuya, Seigo

    2012-01-01

    Radioactive iodine (RAI, 131 I) has been used as a therapeutic agent for differentiated thyroid cancer (DTC) with over 50 years of history. Recently, it is now attracting attention in medical fields as one of the molecular targeting therapies, which is known as targeted radionuclide therapy. Radioactive iodine therapy (RIT) for DTC, however, is now at stake in Japan, because Japan is confronting several problems, including the recent occurrence of the Great East Japan Disaster (GEJD) in March 2011. RIT for DTC is strictly limited in Japan and requires hospitalization. Because of strict regulations, severe lack of medical facilities for RIT has become one of the most important medical problems, which results in prolonged waiting time for Japanese patients with DTC, including those with distant metastasis, who wish to receive RIT immediately. This situation is also due to various other factors, such as prolonged economic recession, super-aging society, and subsequent rapidly changing medical environment. In addition, due to the experience of atomic bombings in Hiroshima and Nagasaki, Japanese people have strong feeling of ''radiophobia ''. There is fear that GEJD and related radiation contamination may worsen this feeling, which might be reflected in more severe regulation of RIT. To overcome these difficulties, it is essential to collect and disclose all information about the circumstances around this therapy in Japan. In this review, we would like to look at this therapy through several lenses, including historical, cultural, medical, and socio-economic points of view. We believe that clarifying the problems is sure to lead to the resolution of this complicated situation. We have also included several recommendations for future improvements. (author)

  2. Globalisations in a nutshell: Historical perspectives on the changing governance of the shea commodity chain in northern Ghana

    Directory of Open Access Journals (Sweden)

    Andrew Wardell

    2013-08-01

    Full Text Available Pre-colonial patterns of trade in West Africa included exchanges of shea in periodic local and regional markets. The collection, processing and marketing of shea products in such markets continues to be predominantly by women to both meet subsistence needs, and exchange of surpluses. In the early part of the 20th century, the British colonial administration considered the possibilities of starting large-scale exports of shea kernels to Europe. Multiple colonial initiatives to develop the global trade were not successful due to a composite of factors. Contemporary patterns of production, trade and regulation are contrasted in the context of globalisation in the post-independence era. The government of Ghana has progressively reinforced its ambitions to expand the shea nut trade as part of the state’s portfolio of major non-traditional agricultural export commodities. This policy is embedded within the (now dominant orthodoxy of neo-liberalism, which privileges monetized production systems and private over public regulation. Historically and culturally-embedded patterns of shea production and trade by women in northern Ghana may now be challenged by the emergence of new processing technologies, the emergence of an oligopolistic global commodity chain and the anticipated continued growth in global demand for cocoa butter equivalents.  Nevertheless, the cumulative impacts of increasing commercialisation and world market integration at the national and local level in Ghana, and other West African producer countries, are still unknown. There are risks, however, that this process may result in social differentiation, changes in household consumption patterns and loss of livelihoods, particularly for women.

  3. Formulation of work stress in 1960-2000: analysis of scientific works from the perspective of historical sociology.

    Science.gov (United States)

    Väänänen, Ari; Anttila, Erkko; Turtiainen, Jussi; Varje, Pekka

    2012-09-01

    During the latter part of the 20th century, work stress became an important societal issue and a huge amount of scientific attention went to studying it. This paper examines the process of formulating and defining the concept of work stress in the occupational health sciences and in industrial and organizational psychology from the early 1960s to the late 1990s. The empirical material of the study encompasses 108 scientific articles, books, book chapters, 'state of the art' reviews, book reviews, and written conference presentations. The data are analysed in the frameworks of historical sociology, critical psychology, and the anthropology of knowledge. We argue that work stress as a life-structuring concept gained ground in psychosocial and occupational health sciences (and also in lay understanding) in the 1960s simultaneously with the rise of social reformist movements that called for fundamental changes emphasizing democratic and human-orientated work organizations and socially responsible values. With the passing of time, however, the focus on structural improvement of work life waned and the emphasis shifted towards the apolitical occupational health aspects of work stress. Researchers with a psychological orientation emphasized micro-level characteristics as factors affecting work stress, whereas stress-orientated epidemiologists turned to the study of specific occupational stress models and/or risk factors. The emergence and development of work stress research can be seen as a chain of attempts to define and identify new risks and experiences occurring in work life. The process, driven by a gradual shift from industrial environments towards organizational frameworks characterized by social and psychological dimensions, reflected the overall shift towards modern democratic work life and the information society in which employees' emotions and well-being became an issue. Copyright © 2012 Elsevier Ltd. All rights reserved.

  4. Historizing epistemology in psychology.

    Science.gov (United States)

    Jovanović, Gordana

    2010-12-01

    The conflict between the psychometric methodological framework and the particularities of human experiences reported in psychotherapeutic context led Michael Schwarz to raise the question whether psychology is based on a methodological error. I take this conflict as a heuristic tool for the reconstruction of the early history of psychology, which bears witness to similar epistemological conflicts, though the dominant historiography of psychology has largely forgotten alternative conceptions and their valuable insights into complexities of psychic phenomena. In order to work against the historical amnesia in psychology I suggest to look at cultural-historical contexts which decisively shaped epistemological choices in psychology. Instead of keeping epistemology and history of psychology separate, which nurtures individualism and naturalism in psychology, I argue for historizing epistemology and for historical psychology. From such a historically reflected perspective psychology in contemporary world can be approached more critically.

  5. Toward an epistemology of nano-technosciences: Probing technoscience from a historical perspective: on today's surprising prevalence and relevance of Francis Bacon.

    Science.gov (United States)

    Schmidt, Jan C

    2011-12-01

    This paper aims to contribute to the attempts to clarify and classify the vague notion of "technosciences" from a historical perspective. A key question that is raised is as follows: Does Francis Bacon, one of the founding fathers of the modern age, provide a hitherto largely undiscovered programmatic position, which might facilitate a more profound understanding of technosciences? The paper argues that nearly everything we need today for an ontologically well-informed epistemology of technoscience can be found in the works of Bacon-this position will be called epistemological real-constructivism. Rather than realist or constructivist, empiricist or rationalist, Bacon's position can best be understood as real-constructivist since it challenges modern dichotomies. Reflection upon the contemporary relevance of Bacon could contribute to the expanding and critical discussion on technoscience. In the following I will reconstruct the term "technoscience". My finding is that at least four different understandings or types of the term "technoscience" co-exist. In a second step, I will analyze and elaborate on Bacon's epistemological position. I will identify central elements of the four different understandings in Bacon's work. Finally, I will conclude that the epistemology of technoscience is, indeed, very old-it is the epistemological position put forward by Bacon.

  6. Health Care Providers in War and Armed Conflict: Operational and Educational Challenges in International Humanitarian Law and the Geneva Conventions, Part I. Historical Perspective.

    Science.gov (United States)

    Burkle, Frederick M; Kushner, Adam L; Giannou, Christos; Paterson, Mary A; Wren, Sherry M; Burnham, Gilbert

    2018-04-30

    Since 1945, the reason for humanitarian crises and the way in which the world responds to them has dramatically changed every 10 to 15 years or less. Planning, response, and recovery for these tragic events have often been ad hoc, inconsistent, and insufficient, largely because of the complexity of global humanitarian demands and their corresponding response system capabilities. This historical perspective chronicles the transformation of war and armed conflicts from the Cold War to today, emphasizing the impact these events have had on humanitarian professionals and their struggle to adapt to increasing humanitarian, operational, and political challenges. An unprecedented independent United Nations-World Health Organization decision in the Battle for Mosul in Iraq to deploy to combat zones emergency medical teams unprepared in the skills of decades-tested war and armed conflict preparation and response afforded to health care providers and dictated by International Humanitarian Law and Geneva Convention protections has abruptly challenged future decision-making and deployments. (Disaster Med Public Health Preparedness. 2018;page 1 of 7).

  7. The Long-term Impact of Early Life Pain On Adult Responses to Anxiety and Stress: Historical Perspectives and Empirical Evidence

    Science.gov (United States)

    Victoria, Nicole C.; Murphy, Anne Z.

    2016-01-01

    Approximately 1 in 6 infants are born prematurely each year. Typically, these infants spend 25 days in the Neonatal Intensive Care Unit (NICU) where they experience 10–18 painful and inflammatory procedures each day. Remarkably, pre-emptive analgesics and/or anesthesia are administered less than 25% of the time. Unalleviated pain during the perinatal period is associated with permanent decreases in pain sensitivity, blunted cortisol responses and high rates of neuropsychiatric disorders. To date, the mechanism(s) by which these long-term changes in stress and pain behavior occur, and whether such alterations can be prevented by appropriate analgesia at the time of insult, remains unclear. Work in our lab using a rodent model of early life pain suggests that inflammatory pain experienced on the day of birth blunts adult responses to stress- and pain-provoking stimuli, and dysregulates the hypothalamic pituitary adrenal (HPA) axis in part through a permanent upregulation in central endogenous opioid tone. This review focuses on the long-term impact of neonatal inflammatory pain on adult anxiety- and stress-related responses, and underlying neuroanatomical changes in the context of endogenous pain control and the HPA axis. These two systems are in a state of exaggerated developmental plasticity early in postnatal life, and work in concert to respond to noxious or aversive stimuli. We present empirical evidence from animal and clinical studies, and discuss historical perspectives underlying the lack of analgesia/anesthetic use for early life pain in the modern NICU. PMID:26210872

  8. Earthquake induced liquefaction hazard, probability and risk assessment in the city of Kolkata, India: its historical perspective and deterministic scenario

    Science.gov (United States)

    Nath, Sankar Kumar; Srivastava, Nishtha; Ghatak, Chitralekha; Adhikari, Manik Das; Ghosh, Ambarish; Sinha Ray, S. P.

    2018-01-01

    synthesized bedrock ground motion for both the 1897 and 1934 earthquakes on non-linear analysis of local site conditions through DEEPSOIL Geotechnical analysis package present surface level peak ground acceleration of the order of 0.05-0.14 g for the 1934 Bihar-Nepal earthquake while for the 1897 Shillong earthquake it is found to be in the range of 0.03-0.11 g. The factor of safety (FOS) against liquefaction, the probability of liquefaction ( P L), the liquefaction potential index (LPI), and the liquefaction risk index are estimated under the influence of these two earthquakes wherein the city is classified into severe (LPI > 15), high (5 65% comprising of coarse-grained sediments of sand, silty sand, and clayey silty sand in mostly the deltaic plain geomorphologic unit with 39.1% sites depicting severe liquefaction hazard with a median LPI of 28.3. A non-linear regression analysis on both the historical and deterministic liquefaction scenarios in P L versus LPI domain with ± 1 standard deviation confidence bound generated a cubic polynomial relationship between the two liquefaction hazard proxies. This study considered a bench mark for other cities in the country and elsewhere forms an integral part of the mega-seismic microzonation endeavors undertaken in all the earthquake-prone counties in the world.

  9. Hydrogen sulfide (H{sub 2}S) and sour gas effects on the eye. A historical perspective

    Energy Technology Data Exchange (ETDEWEB)

    Lambert, Timothy William [Environmental Health, Calgary Health Region, 1509 Centre St SW, Calgary Alberta, T2G 2E6 (Canada)]. E-mail: tim.lambert@calgaryheathregion.ca; Goodwin, Verona Marie [VM Goodwin Research and Consulting Ltd. (Canada); Stefani, Dennis [Environmental Health, Calgary Health Region, 1509 Centre St SW, Calgary Alberta, T2G 2E6 (Canada); Strosher, Lisa [Environmental Health, Calgary Health Region, 1509 Centre St SW, Calgary Alberta, T2G 2E6 (Canada)

    2006-08-15

    The toxicology of hydrogen sulfide (H{sub 2}S) and sour gas on the eye has a long history beginning at least with Ramazzini's observations [Ramazzini B. Diseases of Workers-De Morbis Artificum Diatriba-1713. Wright WC (trans). New York, C. Hafner Publishing Co Inc.; 1964. 98-99 pp.]. In contrast, a recent review by Alberta Health and Wellness (AHW Report) concluded that there is little evidence of eye irritation following short-term exposures to H{sub 2}S at concentrations up to 100 ppm and that the H{sub 2}S literature on the eye is a series of unsubstantiated claims reproduced in review articles dating back to the 1930s [Alberta Health and Wellness (AHW report). Health effects associated with short-term exposure to low levels of hydrogen sulfide: a technical review, Alberta Health and Wellness, October 2002, 81pp.]. In this paper, we evaluated this claim through a historical review of the toxicology of the eye. Ramazzini noted the effects of sewer gas on the eye [Ramazzini B. Diseases of Workers-De Morbis Artificum Diatriba-1713. Wright WC (trans). New York, C. Hafner Publishing Co Inc. 1964. 98-99 pp.]. Lehmann experimentally showed eye effects in men at 70-90 ppm H{sub 2}S and also in animals [Lehmann K. Experimentalle Studien uber den Einfluss technisch und hygienisch wichtiger Gase und Dampfe auf den Organismus. Arch Hyg 1892;14:135-189]. In 1923, Sayers, Mitchell and Yant reported eye effects in animals and men at 50 ppm H{sub 2}S. Barthelemy showed eye effects in animals and men at 20 ppm H{sub 2}S [Barthelemy HL. Ten years' experience with industrial hygiene in connection with the manufacture of viscose rayon. J Ind Hyg Toxicol 1939;21:141-51]. Masure experimentally showed that H{sub 2}S is the causative agent of eye impacts in animals and men [Masure R. La Keratoconjunctivite des filatures de viscose; etude clinique and experiementale. Rev Belge Pathol 1950;20:297-341]. Michal upon microscopic examination of the rat's cornea, found nuclear

  10. PERM Hypothesis: The Fundamental Machinery Able to Elucidate the Role of Xenobiotics and Hormesis in Cell Survival and Homeostasis

    Directory of Open Access Journals (Sweden)

    Salvatore Chirumbolo

    2017-01-01

    Full Text Available In this article the Proteasome, Endoplasmic Reticulum and Mitochondria (PERM hypothesis is discussed. The complex machinery made by three homeostatic mechanisms involving the proteasome (P, endoplasmic reticulum (ER and mitochondria (M is addressed in order to elucidate the beneficial role of many xenobiotics, either trace metals or phytochemicals, which are spread in the human environment and in dietary habits, exerting their actions on the mechanisms underlying cell survival (apoptosis, cell cycle regulation, DNA repair and turnover, autophagy and stress response. The “PERM hypothesis” suggests that xenobiotics can modulate this central signaling and the regulatory engine made fundamentally by the ER, mitochondria and proteasome, together with other ancillary components such as peroxisomes, by acting on the energetic balance, redox system and macromolecule turnover. In this context, reactive species and stressors are fundamentally signalling molecules that could act as negative-modulating signals if PERM-mediated control is offline, impaired or dysregulated, as occurs in metabolic syndrome, degenerative disorders, chronic inflammation and cancer. Calcium is an important oscillatory input of this regulation and, in this hypothesis, it might play a role in maintaining the correct rhythm of this PERM modulation, probably chaotic in its nature, and guiding cells to a more drastic decision, such as apoptosis. The commonest effort sustained by cells is to maintain their survival balance and the proterome has the fundamental task of supporting this mechanism. Mild stress is probably the main stimulus in this sense. Hormesis is therefore re-interpreted in the light of this hypothetical model and that experimental evidence arising from flavonoid and hormesis reasearch.

  11. Azadirachtin-induced hormesis mediating shift in fecundity-longevity trade-off in the Mexican bean weevil (Chrysomelidae: Bruchinae).

    Science.gov (United States)

    Mallqui, K S Vilca; Vieira, J L; Guedes, R N C; Gontijo, L M

    2014-04-01

    Insecticides can have lethal or sublethal effects upon targeted pest species, and sublethal effects may even favor pest outbreaks if insecticide-induced hormesis occurs. Hormesis is a biphasic dose-response of a given chemical compound that is stimulatory at low doses and toxic at high doses. The former response may result from the disruption of animal homeostasis leading to trade-off shifts between basic ecophysiological processes. A growing interest in the use of biorational insecticides, such as azadirachtin to control stored-product pests, raises concerns about potential sublethal effects. In this study, we explored the hypothesis that azadirachtin can negatively impact the reproductive capacity of the Mexican bean weevil, Zabrotes subfasciatus (Boheman) (Chrysomelidae: Bruchinae), a key pest of stored beans. In addition, we investigated whether adults of this species could compensate for any sublethal effect that might have affected any of their reproductive parameters by adjusting the allocation of its reproductive efforts. The results showed that females of Z. subfasciatus increased fecundity daily to compensate for azadirachtin-induced decreased longevity. In addition, a stage-structured matrix study revealed that populations of Z. subfasciatus engendered from females exposed to azadirachtin exhibited a higher rate of population increase (r) and a higher net reproductive rate (R(o)). Finally, a projection matrix analysis showed notably higher densities along the generations for azadirachtin-exposed Z. subfasciatus populations. Thus, our study provides empirical evidence for the capacity of Z. subfasciatus to adapt to sublethal effects caused by biorational insecticides; consequently, this study highlights the importance of understanding this phenomenon when devising pest management strategies.

  12. Herbicide toxicity, selectivity and hormesis of nicosulfuron on 10 Trichogrammatidae (Hymenoptera) species parasitizing Anagasta ( = Ephestia) kuehniella (Lepidoptera: Pyralidae) eggs.

    Science.gov (United States)

    Leite, Germano L D; de Paulo, Paula D; Zanuncio, José C; Tavares, Wagner De S; Alvarenga, Anarelly C; Dourado, Luan R; Bispo, Edilson P R; Soares, Marcus A

    2017-01-02

    Selective agrochemicals including herbicides that do not affect non-target organisms such as natural enemies are important in the integrated pest management (IPM) programs. The aim of this study was to evaluate the herbicide toxicity, selectivity and hormesis of nicosulfuron, recommended for the corn Zea mays L. (Poaceae) crop, on 10 Trichogrammatidae (Hymenoptera) species. A female of each Trichogramma spp. or Trichogrammatoidea annulata De Santis, 1972 was individually placed in plastic test tubes (no choice) with a cardboard containing 45 flour moth Anagasta ( = Ephestia) kuehniella Zeller, 1879 (Lepidoptera: Pyralidae) eggs. Parasitism by these natural enemies was allowed for 48 h and the cardboards were sprayed with the herbicide nicosulfuron at 1.50 L.ha -1 , along with the control (only distilled water). Nicosulfuron reduced the emergence rate of Trichogramma bruni Nagaraja, 1983 females, but increased that of Trichogramma pretiosum Riley, 1879, Trichogramma acacioi Brun, Moraes and Smith, 1984 and T. annulata females. Conversely, this herbicide increased the emergence rate of Trichogramma brasiliensis Ashmead, 1904, T. bruni, Trichogramma galloi Zucchi, 1988 and Trichogramma soaresi Nagaraja, 1983 males and decreased those of T. acacioi, Trichogramma atopovilia Oatman and Platner, 1983 and T. pretiosum males. In addition, nicosulfuron reduced the sex ratio of T. galloi, Trichogramma bennetti Nagaraja and Nagarkatti, 1973 and T. pretiosum and increased that of T. acacioi, T. bruni, T. annulata, Trichogramma demoraesi Nagaraja, 1983, T. soaresi and T. brasiliensis. The herbicide nicosulfuron was "harmless" (class 1, <30% reduction) for females and the sex ratio of all Trichogrammatidae species based on the International Organization for Biological Control (IOBC) classification. The possible hormesis effect of nicosulfuron on Trichogrammatidae species and on the bacterium Wolbachia sp. (Rickettsiales: Rickettsiaceae) was also discussed.

  13. Perspective

    DEFF Research Database (Denmark)

    Kussmann, Martin; Morine, Melissa J; Hager, Jörg

    2013-01-01

    We review here the status of human type 2 diabetes studies from a genetic, epidemiological, and clinical (intervention) perspective. Most studies limit analyses to one or a few omic technologies providing data of components of physiological processes. Since all chronic diseases are multifactorial...... at different time points along this longitudinal investigation are performed with a comprehensive set of omics platforms. These data sets are generated in a biological context, rather than biochemical compound class-driven manner, which we term "systems omics."...

  14. Power Relations in Parinoush Sani’ee’s Sahm-e Man (The Book of Fate: A New-historical Perspective

    Directory of Open Access Journals (Sweden)

    Ali Taghizadeh

    2015-12-01

    Full Text Available This paper is an attempt to critically analyze Parinoush Sani’ee’s Sahm-e Man (translated into English as The Book of Fate from a New-historical perspective. Beginning from before the 1979 Iranian Revolution, and going forward through the reign of the Islamic Republic to the current years, the time-line of the story shows five decades of changing fortunes of Sani’ee’s main character. Reading her book in the light of New-historicism, this paper tries to show how the story reflects Foucauldian notions of resistance, power relations, normalization, and self-formation in the five phases of Massoumeh’s life. Considering Foucault’s arguments on how power imposes ideology on the citizens, the paper also tries to reflect how it changes in each phase of Massoumeh’s life and how it normalizes her to make her into a docile subject whom it can best control. Added to that, the paper tries to demonstrate her success in resisting the power and acquiring an ethical self through practicing a care for her ‘self’. However, in spite of all her resistances to power and normalization, in the last phase of the story when the novel’s discourse is more emotional, Massoumeh gives up resistance and accepts normalization, and for the sake of her children’s satisfaction, rejects Saiid’s proposal, and like most of the widows in her age, decides to live alone to the end of her life.

  15. The long-term impact of early life pain on adult responses to anxiety and stress: Historical perspectives and empirical evidence.

    Science.gov (United States)

    Victoria, Nicole C; Murphy, Anne Z

    2016-01-01

    Approximately 1 in 6 infants are born prematurely each year. Typically, these infants spend 25 days in the Neonatal Intensive Care Unit (NICU) where they experience 10-18 painful and inflammatory procedures each day. Remarkably, pre-emptive analgesics and/or anesthesia are administered less than 25% of the time. Unalleviated pain during the perinatal period is associated with permanent decreases in pain sensitivity, blunted cortisol responses and high rates of neuropsychiatric disorders. To date, the mechanism(s) by which these long-term changes in stress and pain behavior occur, and whether such alterations can be prevented by appropriate analgesia at the time of insult, remains unclear. Work in our lab using a rodent model of early life pain suggests that inflammatory pain experienced on the day of birth blunts adult responses to stress- and pain-provoking stimuli, and dysregulates the hypothalamic pituitary adrenal (HPA) axis in part through a permanent upregulation in central endogenous opioid tone. This review focuses on the long-term impact of neonatal inflammatory pain on adult anxiety- and stress-related responses, and underlying neuroanatomical changes in the context of endogenous pain control and the HPA axis. These two systems are in a state of exaggerated developmental plasticity early in postnatal life, and work in concert to respond to noxious or aversive stimuli. We present empirical evidence from animal and clinical studies, and discuss historical perspectives underlying the lack of analgesia/anesthetic use for early life pain in the modern NICU. Copyright © 2015 Elsevier Inc. All rights reserved.

  16. Historical perspective of Indian neurology.

    Science.gov (United States)

    Mishra, Shrikant; Trikamji, Bhavesh; Singh, Sandeep; Singh, Parampreet; Nair, Rajasekharan

    2013-10-01

    To chronicle the history of medicine and neurology in India with a focus on its establishment and evolution. THE HISTORY OF NEUROLOGY IN INDIA IS DIVIDED INTO TWO PERIODS: ancient and modern. The ancient period dates back to the mid-second millennium Before Christ (B.C.) during the creation of the Ayurvedic Indian system of Medicine, which detailed descriptions of neurological disorders called Vata Vyadhi. The early 20(th) century witnessed the birth of modern Indian medicine with the onset of formal physician training at the nation's first allopathic medical colleges located in Madras (1835), Calcutta (1835) and Mumbai (1848). Prior to India's independence from Britain in 1947, only 25 medical schools existed in the entire country. Today, there are over 355. In 1951, physicians across the field of neurology and neurosurgery united to create the Neurological Society of India (NSI). Four decades later in 1991, neurologists branched out to establish a separate organization called the Indian Academy of Neurology (IAN). Information was gathered through literature review using PubMed, MD Consult, OVID, primary texts and research at various academic institutions in India. Neurological disorders were first described in ancient India under Ayurveda. The transition to modern medicine occurred more recently through formal training at medical schools beginning in the 1930's. Early pioneers and founders of the NSI (1951) include Dr. Jacob Chandy, Dr. B Ramamurthi, Dr. S. T. Narasimhan and Dr. Baldev Singh. Later, Dr. J. S. Chopra, a prominent neurologist and visionary, recognized the need for primary centers of collaboration and subsequently established the IAN (1991). The future of Neurology in India is growing rapidly. Currently, there are 1100 practicing neurologists and more than 150 post-graduate trainees who join the ranks every year. As the number of neurologists rises across India, there is an increase in the amount of basic, clinical and epidemiological research being conducted across the country every day. The history of neurology in India roots back to its rich culture and tradition. Over time, there has been great structural and organizational evolution and the future of neurology in India appears to be bright. However, the number of neurologists and research in neurology needs to experience a significant growth in the future to ensure the best patient care.

  17. A historical perspective of laminitis.

    Science.gov (United States)

    Heymering, Henry W

    2010-04-01

    The causes of laminitis are many-often interrelated, sometimes direct opposites. The history of laminitis has been a search for the cause or causes of laminitis and for effective treatment. Going in and out of fashion, many treatments have lasted for centuries, some for millennia, but very few have been proven. Copyright 2010 Elsevier Inc. All rights reserved.

  18. Historical perspectives on cadmium toxicology

    International Nuclear Information System (INIS)

    Nordberg, Gunnar F.

    2009-01-01

    The first health effects of cadmium (Cd) were reported already in 1858. Respiratory and gastrointestinal symptoms occurred among persons using Cd-containing polishing agent. The first experimental toxicological studies are from 1919. Bone effects and proteinuria in humans were reported in the 1940's. After World War II, a bone disease with fractures and severe pain, the itai-itai disease, a form of Cd-induced renal osteomalacia, was identified in Japan. Subsequently, the toxicokinetics and toxicodynamics of Cd were described including its binding to the protein metallothionein. International warnings of health risks from Cd-pollution were issued in the 1970's. Reproductive and carcinogenic effects were studied at an early stage, but a quantitative assessment of these effects in humans is still subject to considerable uncertainty. The World Health Organization in its International Program on Chemical Safety, WHO/IPCS (1992) (Cadmium. Environmental Health Criteria Document 134, IPCS. WHO, Geneva, 1-280.) identified renal dysfunction as the critical effect and a crude quantitative evaluation was presented. In the 1990's and 2000 several epidemiological studies have reported adverse health effects, sometimes at low environmental exposures to Cd, in population groups in Japan, China, Europe and USA (reviewed in other contributions to the present volume). The early identification of an important role of metallothionein in cadmium toxicology formed the basis for recent studies using biomarkers of susceptibility to development of Cd-related renal dysfunction such as gene expression of metallothionein in peripheral lymphocytes and autoantibodies against metallothionein in blood plasma. Findings in these studies indicate that very low exposure levels to cadmium may give rise to renal dysfunction among sensitive subgroups of human populations such as persons with diabetes.

  19. Schwarzschild Solution: A Historical Perspective

    Science.gov (United States)

    Bartusiak, Marcia

    2016-03-01

    While eighteenth-century Newtonians had imagined a precursor to the black hole, the modern version has its roots in the first full solution to Einstein's equations of general relativity, derived by the German astronomer Karl Schwarzschild on a World War I battlefront just weeks after Einstein introduced his completed theory in November 1915. This talk will demonstrate how Schwarzschild's solution is linked to the black hole and how it took more than half a century for the physics community to accept that such a bizarre celestial object could exist in the universe.

  20. Historical perspective of Indian neurology

    Directory of Open Access Journals (Sweden)

    Shrikant Mishra

    2013-01-01

    Full Text Available Objective: To chronicle the history of medicine and neurology in India with a focus on its establishment and evolution. Background: The history of neurology in India is divided into two periods: ancient and modern. The ancient period dates back to the mid-second millennium Before Christ (B.C. during the creation of the Ayurvedic Indian system of Medicine, which detailed descriptions of neurological disorders called Vata Vyadhi. The early 20 th century witnessed the birth of modern Indian medicine with the onset of formal physician training at the nation′s first allopathic medical colleges located in Madras (1835, Calcutta (1835 and Mumbai (1848. Prior to India′s independence from Britain in 1947, only 25 medical schools existed in the entire country. Today, there are over 355. In 1951, physicians across the field of neurology and neurosurgery united to create the Neurological Society of India (NSI. Four decades later in 1991, neurologists branched out to establish a separate organization called the Indian Academy of Neurology (IAN. Design/Methods: Information was gathered through literature review using PubMed, MD Consult, OVID, primary texts and research at various academic institutions in India. Results: Neurological disorders were first described in ancient India under Ayurveda. The transition to modern medicine occurred more recently through formal training at medical schools beginning in the 1930′s. Early pioneers and founders of the NSI (1951 include Dr. Jacob Chandy, Dr. B Ramamurthi, Dr. S. T. Narasimhan and Dr. Baldev Singh. Later, Dr. J. S. Chopra, a prominent neurologist and visionary, recognized the need for primary centers of collaboration and subsequently established the IAN (1991. The future of Neurology in India is growing rapidly. Currently, there are 1100 practicing neurologists and more than 150 post-graduate trainees who join the ranks every year. As the number of neurologists rises across India, there is an increase in the amount of basic, clinical and epidemiological research being conducted across the country every day. Conclusions: The history of neurology in India roots back to its rich culture and tradition. Over time, there has been great structural and organizational evolution and the future of neurology in India appears to be bright. However, the number of neurologists and research in neurology needs to experience a significant growth in the future to ensure the best patient care.

  1. Cognitive Dominance: A Historical Perspective

    Science.gov (United States)

    2015-05-23

    pregnant woman preparing for the birth of her child . When asked about his genius, Napoleon responded that genius did not occur naturally, but came only...near Saint Louis, Missouri. There he met his future wife, Julia Dent. The Mexican War intervened, and Grant had to wait until the campaign ended to...land Julia inherited from her family. Grant spent the first year clearing the land, then a second year building a log cabin for his family. He could

  2. Accountability--A Historical Perspective.

    Science.gov (United States)

    Keefover, Karen Shade

    1983-01-01

    Asserts that existing accountability policies assume that a single behaviorist theory is the one best system for effective education. Examines the pitfalls of the one-system approach through the examples of John Stuart Mill's utilitarian upbringing and "Gradgrindism" in Charles Dickens' novel "Hard Times." (SK)

  3. Women in Sport: Historical Perspectives.

    Science.gov (United States)

    Gregg, Elizabeth A; Gregg, Vanessa H

    2017-10-01

    The history of women in sport in America was shaped by Victorian ideals and other belief systems prevalent during the nineteenth century. Medical experts of that era believed that intense exercise and competition could cause women to become masculine, threaten their ability to bear children, and create other reproductive health complications. Consequently, sport for women was reserved for upper-class women until the mid-twentieth century. Title IX of the Education Amendments had a significant and lasting impact on sport in America. Today, girls and women are enjoying sport at the interscholastic, intercollegiate, and professional levels comparable with their male counterparts. Copyright © 2017 Elsevier Inc. All rights reserved.

  4. REDUCTIONS WITHOUT REGRET: HISTORICAL PERSPECTIVES

    Energy Technology Data Exchange (ETDEWEB)

    Swegle, J.; Tincher, D.

    2013-09-09

    This is the first of three papers (in addition to an introductory summary) aimed at providing a framework for evaluating future reductions or modifications of the U.S. nuclear force, first by considering previous instances in which nuclear-force capabilities were eliminated; second by looking forward into at least the foreseeable future at the features of global and regional deterrence (recognizing that new weapon systems currently projected will have expected lifetimes stretching beyond our ability to predict the future); and third by providing examples of past or possible undesirable outcomes in the shaping of the future nuclear force, as well as some closing thoughts for the future. This paper examines the circumstances and consequences of the elimination of The INF-range Pershing II ballistic missile and Gryphon Ground-Launched Cruise Missile (GLCM), deployed by NATO under a dual-track strategy to counter Soviet intermediate-range missiles while pursuing negotiations to limit or eliminate all of these missiles. The Short-Range Attack Missile (SRAM), which was actually a family of missiles including SRAM A, SRAM B (never deployed), and SRAM II and SRAM T, these last two cancelled during an over-budget/behind-schedule development phase as part of the Presidential Nuclear Initiatives of 1991 and 1992. The nuclear-armed version of the Tomahawk Land-Attack Cruise Missile (TLAM/N), first limited to shore-based storage by the PNIs, and finally eliminated in deliberations surrounding the 2010 Nuclear Posture Review Report. The Missile-X (MX), or Peacekeeper, a heavy MIRVed ICBM, deployed in fixed silos, rather than in an originally proposed mobile mode. Peacekeeper was likely intended as a bargaining chip to facilitate elimination of Russian heavy missiles. The plan failed when START II did not enter into force, and the missiles were eliminated at the end of their intended service life. The Small ICBM (SICBM), or Midgetman, a road-mobile, single-warhead missile for which per-unit costs were climbing when it was eliminated under the PNIs. Although there were liabilities associated with each of these systems, there were also unique capabilities; this paper lays out the pros and cons for each. Further, we articulate the capabilities that were eliminated with these systems.

  5. Metropolitan siting: a historical perspective

    International Nuclear Information System (INIS)

    Bunch, D.F.

    1978-09-01

    The paper discusses the development and implementation of the Reactor Site Criteria and particularly the evolving posture of the agency on the subject of metropolitan siting. The review actions on nine sites are described to illustrate the various issues and positions and to clarify at least some of the bases for current practices of the NRC staff

  6. Database Security: A Historical Perspective

    OpenAIRE

    Lesov, Paul

    2010-01-01

    The importance of security in database research has greatly increased over the years as most of critical functionality of the business and military enterprises became digitized. Database is an integral part of any information system and they often hold sensitive data. The security of the data depends on physical security, OS security and DBMS security. Database security can be compromised by obtaining sensitive data, changing data or degrading availability of the database. Over the last 30 ye...

  7. Testosterone deficiency: a historical perspective

    Directory of Open Access Journals (Sweden)

    Eberhard Nieschlag

    2014-02-01

    Full Text Available The biological effects of the testes and testosterone are known since antiquity. Aristotle knew the effects of castration and his hypothesis on fertilization is one of the first scientific encounters in reproductive biology. Over centuries, castration has been performed as punishment and to produce obedient slaves, but also to preserve the soprano voices of prepubertal boys. The Chinese imperial (and other oriental courts employed castrates as overseers in harems who often obtained high-ranking political positions. The era of testis transplantation and organotherapy was initiated by John Hunter in London who transplanted testes into capons in 1786. The intention of his experiments was to prove the 'vital principle' as the basis for modern transplantation medicine, but Hunter did not consider endocrine aspects. Arnold Adolph Berthold postulated internal secretion from his testicular transplantation experiments in 1849 in Göttingen and is thus considered the father of endocrinology. Following his observations, testicular preparations were used for therapy, popularized by self-experiments by Charles-Edouard Brown-Séquard in Paris (1889, which can at best have placebo effects. In the 1920s Sergio Voronoff transplanted testes from animals to men, but their effectiveness was disproved. Today testicular transplantation is being refined by stem cell research and germ cell transplantation. Modern androgen therapy started in 1935 when Enrest Lacquer isolated testosterone from bull testes in Amsterdam. In the same year testosterone was chemically synthesized independently by Adolf Butenandt in Göttingen and Leopold Ruzicka in Basel. Since testosterone was ineffective orally it was either compressed into subcutaneous pellets or was used orally as 17α-methyl testosterone, now obsolete because of liver toxicity. The early phases of testosterone treatment coincide with the first description of the most prominent syndromes of hypogonadism by Klinefelter, by Kallmann, DelCastillo and Pasqualini. In the 1950s longer-acting injectable testosterone enanthate became the preferred therapeutic modality. In the 1950s and 1960s, research concentrated on the chemical modification of androgens in order to emphasize their anabolic effects. Although anabolic steroids have largely disappeared from clinical medicine, they continue to live an illegal life for doping in athletics. In the 1970s the orally effective testosterone undecanoate was added to the spectrum of preparations. Recent transdermal gels and long-acting injectable preparations provide options for physiological testosterone substitution therapy.

  8. Vesicoureteral reflux: A historical perspective

    African Journals Online (AJOL)

    K.N. DeCotiis

    2016-12-28

    Dec 28, 2016 ... Abstract. The management of vesicoureteral reflux is a mainstay of pediatric urology. ... exponential relationship between number of urinary tract infections, .... dysfunction as an independent predictor of low reflux resolution.

  9. Wilderness science: A historical perspective

    Science.gov (United States)

    David N. Cole

    2014-01-01

    Wilderness is a relatively new and powerful idea that is still finding its footing in the world of science. Although the intellectual history of wilderness can be traced farther back in time (Nash 2001), as a land classification wilderness is less than a century old, and it was just 50 years ago that wilderness was codified in legislation in the United States. While...

  10. Historical Research: A Qualitative Perspective.

    Science.gov (United States)

    Heller, George N.

    1996-01-01

    Provides a brief overview of the uses of rhetoric in the history of writing about music. Discusses Aristotle's topology of the three different kinds of rhetoric: deliberative, judicial, and epideictic (demonstrative). Includes excerpts from past music criticism, copious notes, and a 27-item bibliography. (MJP)

  11. Waste vitrification: a historical perspective

    International Nuclear Information System (INIS)

    McElroy, J.L.; Bjorklund, W.J.; Bonner, W.F.

    1982-02-01

    The possibility of converting high-level wastes (HLW) to glass was first pursued in Canada and England at a time when other countries were evaluating many other alternatives. By 1966, the British had completed radioactive demonstrations of the FINGAL pot process, converting HLW to borosilicate glass. By this time other countries, including France and the United States, had begun using the glass waste form. Beginning in 1966, several processes, including phosphate and borosilicate glass, were demonstrated by the US in the Waste Solidification Engineering Prototypes (WSEP) program at the Pacific Northwest Laboratory (PNL). Most of the current vitrification processes are adaptations of the FINGAL pot process or the continuous metallic melter used in the WSEP program. One notable exception is the joule-heated ceramic melter, which was adapted from commercial glass technology for HLW by PNL in the mid-1970's. Both batch and continuous processes have been developed to an advanced stage of readiness. These processes are described and compared in this paper

  12. Selective toxin effects on faster and slower growing individuals in the formation of hormesis at the population level - A case study with Lactuca sativa and PCIB.

    Science.gov (United States)

    Belz, Regina G; Sinkkonen, Aki

    2016-10-01

    Natural plant populations have large phenotypic plasticity that enhances acclimation to local stress factors such as toxin exposures. While consequences of high toxin exposures are well addressed, effects of low-dose toxin exposures on plant populations are seldom investigated. In particular, the importance of 'selective low-dose toxicity' and hormesis, i.e. stimulatory effects, has not been studied simultaneously. Since selective toxicity can change the size distribution of populations, we assumed that hormesis alters the size distribution at the population level, and investigated whether and how these two low-dose phenomena coexist. The study was conducted with Lactuca sativa L. exposed to the auxin-inhibitor 2-(p-chlorophenoxy)-2-methylpropionic acid (PCIB) in vitro. In two separate experiments, L. sativa was exposed to 12 PCIB doses in 24 replicates (50 plants/replicate). Shoot/root growth responses at the population level were compared to the fast-growing (≥90% percentile) and the slow-growing subpopulations (≤10% percentile) by Mann-Whitney U testing and dose-response modelling. In the formation of pronounced PCIB hormesis at the population level, low-dose effects proved selective, but widely stimulatory which seems to counteract low-dose selective toxicity. The selectivity of hormesis was dose- and growth rate-dependent. Stimulation occurred at lower concentrations and stimulation percentage was higher among slow-growing individuals, but partly or entirely masked at the population level by moderate or negligible stimulation among the faster growing individuals. We conclude that the hormetic effect up to the maximum stimulation may be primarily facilitated by an increase in size of the most slow-growing individuals, while thereafter it seems that mainly the fast-growing individuals contributed to the observed hormesis at the population level. As size distribution within a population is related to survival, our study hints that selective effects on slow

  13. Biblical Interpretation Beyond Historicity

    DEFF Research Database (Denmark)

    Biblical Interpretation beyond Historicity evaluates the new perspectives that have emerged since the crisis over historicity in the 1970s and 80s in the field of biblical scholarship. Several new studies in the field, as well as the ‘deconstructive’ side of literary criticism that emerged from...... writers such as Derrida and Wittgenstein, among others, lead biblical scholars today to view the texts of the Bible more as literary narratives than as sources for a history of Israel. Increased interest in archaeological and anthropological studies in writing the history of Palestine and the ancient Near...... and the commitment to a new approach to both the history of Palestine and the Bible’s place in ancient history. This volume features essays from a range of highly regarded scholars, and is divided into three sections: “Beyond Historicity”, which explores alternative historical roles for the Bible, “Greek Connections...

  14. Vegetable and synthetic tannins induce hormesis/toxicity in sea urchin early development and in algal growth

    International Nuclear Information System (INIS)

    De Nicola, Elena; Meric, Suereyya; Gallo, Marialuisa; Iaccarino, Mario; Della Rocca, Claudio; Lofrano, Giusy; Russo, Teresa; Pagano, Giovanni

    2007-01-01

    Mimosa tannin and phenol-based synthetic tannin (syntan) were tested for toxicity to sea urchin (Paracentrotus lividus and Sphaerechinus granularis) early development and to marine algal growth (Dunaliella tertiolecta). Sea urchin embryogenesis was affected by vegetable tannin and syntan water extracts (VTWE and STWE) at levels ≥1 mg/L. Developmental defects were significantly decreased at VTWE and STWE levels of 0.1 and 0.3 mg/L when control cultures displayed suboptimal quality, i.e. <70% 'viable' (normal or retarded) larvae. Fertilization success of sea urchin sperm was increased up to 0.3 mg/L STWE or VTWE, then was inhibited by increasing tannin levels (1-30 mg/L). Offspring abnormalities, following sperm exposure to VTWE or STWE, showed the same shift from hormesis to toxicity. Cell growth bioassays in D. tertiolecta exposed to VTWE or STWE (0.1-30 mg/L) showed non-linear concentration-related toxicity. Novel criteria are suggested in defining control quality that should reveal hormetic effects. - Vegetable tannin and synthetic tannins were moderately toxic or displayed hormetic effects in sea urchins and in algae. Re-defining control quality is needed for evaluating hormetic effects

  15. Vegetable and synthetic tannins induce hormesis/toxicity in sea urchin early development and in algal growth

    Energy Technology Data Exchange (ETDEWEB)

    De Nicola, Elena [Italian National Cancer Institute, G. Pascale Foundation, via M. Semmola, I-80131 Naples (Italy); Meric, Suereyya [Department of Civil Engineering, Salerno University, I-84084 Fisciano (Italy); Gallo, Marialuisa [Campania Regional Agency for Environmental Protection (ARPAC), I-80143 Naples (Italy); Iaccarino, Mario [Italian National Cancer Institute, G. Pascale Foundation, via M. Semmola, I-80131 Naples (Italy); Della Rocca, Claudio [Department of Civil Engineering, Salerno University, I-84084 Fisciano (Italy); Lofrano, Giusy [Department of Civil Engineering, Salerno University, I-84084 Fisciano (Italy); Russo, Teresa [Campania Regional Agency for Environmental Protection (ARPAC), I-80143 Naples (Italy); Pagano, Giovanni [Italian National Cancer Institute, G. Pascale Foundation, via M. Semmola, I-80131 Naples (Italy)]. E-mail: gbpagano@tin.it

    2007-03-15

    Mimosa tannin and phenol-based synthetic tannin (syntan) were tested for toxicity to sea urchin (Paracentrotus lividus and Sphaerechinus granularis) early development and to marine algal growth (Dunaliella tertiolecta). Sea urchin embryogenesis was affected by vegetable tannin and syntan water extracts (VTWE and STWE) at levels {>=}1 mg/L. Developmental defects were significantly decreased at VTWE and STWE levels of 0.1 and 0.3 mg/L when control cultures displayed suboptimal quality, i.e. <70% 'viable' (normal or retarded) larvae. Fertilization success of sea urchin sperm was increased up to 0.3 mg/L STWE or VTWE, then was inhibited by increasing tannin levels (1-30 mg/L). Offspring abnormalities, following sperm exposure to VTWE or STWE, showed the same shift from hormesis to toxicity. Cell growth bioassays in D. tertiolecta exposed to VTWE or STWE (0.1-30 mg/L) showed non-linear concentration-related toxicity. Novel criteria are suggested in defining control quality that should reveal hormetic effects. - Vegetable tannin and synthetic tannins were moderately toxic or displayed hormetic effects in sea urchins and in algae. Re-defining control quality is needed for evaluating hormetic effects.

  16. Sexual Success after Stress? Imidacloprid-Induced Hormesis in Males of the Neotropical Stink Bug Euschistus heros

    Science.gov (United States)

    Haddi, Khalid; Mendes, Marcos V.; Lino-Neto, José; Freitas, Hemerson L.; Guedes, Raul Narciso C.; Oliveira, Eugênio E.

    2016-01-01

    Environmental stress in newly-emerged adult insects can have dramatic consequences on their life traits (e.g., dispersion, survival and reproduction) as adults. For instance, insects sublethally exposed to environmental stressors (e.g., insecticides) can gain fitness benefits as a result of hormesis (i.e., benefits of low doses of compounds that would be toxic at higher doses). Here, we experimentally tested whether sublethal exposure to the insecticide imidacloprid would hormetically affect the sexual fitness of newly-emerged adults of the Neotropical brown stink bug Euschistus heros (Hemiptera: Heteroptera: Pentatomidae), which is the most abundant and prevalent insect pest in Neotropical soybean fields. We evaluated the sexual fitness of four couple combinations: unexposed couples, exposed females, exposed males, and exposed couples. Sublethal exposure to dry residues (i.e., contact) of imidacloprid (at 1% of recommended field rate) did not affect insect survival, but led to higher mating frequencies when at least one member of the couple was exposed. However, the average mating duration was shortened when only females were exposed to imidacloprid. Moreover, exposed males showed higher locomotory (walking) activity, lower respiration rates and induced higher fecundity rates when mated to unexposed females. Although the reproductive tracts of exposed males did not differ morphometrically from unexposed males, their accessory glands exhibited positive reactions for acidic and basic contents. Our findings suggest that males of the Neotropical brown stink bug hormetically increase their sexual fitness when cued by impending insecticidal stress in early adulthood. PMID:27284906

  17. Sexual Success after Stress? Imidacloprid-Induced Hormesis in Males of the Neotropical Stink Bug Euschistus heros.

    Directory of Open Access Journals (Sweden)

    Khalid Haddi

    Full Text Available Environmental stress in newly-emerged adult insects can have dramatic consequences on their life traits (e.g., dispersion, survival and reproduction as adults. For instance, insects sublethally exposed to environmental stressors (e.g., insecticides can gain fitness benefits as a result of hormesis (i.e., benefits of low doses of compounds that would be toxic at higher doses. Here, we experimentally tested whether sublethal exposure to the insecticide imidacloprid would hormetically affect the sexual fitness of newly-emerged adults of the Neotropical brown stink bug Euschistus heros (Hemiptera: Heteroptera: Pentatomidae, which is the most abundant and prevalent insect pest in Neotropical soybean fields. We evaluated the sexual fitness of four couple combinations: unexposed couples, exposed females, exposed males, and exposed couples. Sublethal exposure to dry residues (i.e., contact of imidacloprid (at 1% of recommended field rate did not affect insect survival, but led to higher mating frequencies when at least one member of the couple was exposed. However, the average mating duration was shortened when only females were exposed to imidacloprid. Moreover, exposed males showed higher locomotory (walking activity, lower respiration rates and induced higher fecundity rates when mated to unexposed females. Although the reproductive tracts of exposed males did not differ morphometrically from unexposed males, their accessory glands exhibited positive reactions for acidic and basic contents. Our findings suggest that males of the Neotropical brown stink bug hormetically increase their sexual fitness when cued by impending insecticidal stress in early adulthood.

  18. Hormesis and stage specific toxicity induced by cadmium in an insect model, the queen blowfly, Phormia regina Meig

    Energy Technology Data Exchange (ETDEWEB)

    Nascarella, Marc A.; Stoffolano, John G.; Stanek, Edward J.; Kostecki, Paul T.; Calabrese, Edward J

    2003-07-01

    This is the first report of a heavy metal displaying a hormetic-like biphasic response for early developmental success, while at the same time displaying stage-specific toxicity at a later developmental stage. - Hormesis is an adaptive response, commonly characterized by a biphasic dose-response that can be either directly induced, or the result of compensatory biological processes following an initial disruption in homeostasis [Calabrese and Baldwin, Hum. Exp. Toxicol., 21 (2002), 91]. Low and environmentally relevant levels of dietary cadmium significantly enhanced the pupation rate of blowfly larvae, while higher doses inhibited pupation success. However, dietary cadmium at all exposure levels adversely affected the emergence of the adult fly from the pupal case. Such findings represent the first report of a heavy metal displaying a hormetic-like biphasic response for pupation success, while at the same time displaying stage-specific toxicity at a later developmental period. These conclusions are based on substantial experimentation of over 1750 blowflies, in seven replicate experiments, involving 10 concentrations per experiment. These findings indicate the need to assess the impact of environmental stressors over a broad range of potential exposures as well as throughout the entire life cycle.

  19. Hormesis and stage specific toxicity induced by cadmium in an insect model, the queen blowfly, Phormia regina Meig

    International Nuclear Information System (INIS)

    Nascarella, Marc A.; Stoffolano, John G.; Stanek, Edward J.; Kostecki, Paul T.; Calabrese, Edward J.

    2003-01-01

    This is the first report of a heavy metal displaying a hormetic-like biphasic response for early developmental success, while at the same time displaying stage-specific toxicity at a later developmental stage. - Hormesis is an adaptive response, commonly characterized by a biphasic dose-response that can be either directly induced, or the result of compensatory biological processes following an initial disruption in homeostasis [Calabrese and Baldwin, Hum. Exp. Toxicol., 21 (2002), 91]. Low and environmentally relevant levels of dietary cadmium significantly enhanced the pupation rate of blowfly larvae, while higher doses inhibited pupation success. However, dietary cadmium at all exposure levels adversely affected the emergence of the adult fly from the pupal case. Such findings represent the first report of a heavy metal displaying a hormetic-like biphasic response for pupation success, while at the same time displaying stage-specific toxicity at a later developmental period. These conclusions are based on substantial experimentation of over 1750 blowflies, in seven replicate experiments, involving 10 concentrations per experiment. These findings indicate the need to assess the impact of environmental stressors over a broad range of potential exposures as well as throughout the entire life cycle

  20. George Wallis (1811-1891) and Ernest Beinfeld Havell (1861-1934): Juxtaposing Historical Perspectives on Nineteenth-Century Drawing Books in England and India

    Science.gov (United States)

    Kantawala, Ami; Daichendt, G. James

    2017-01-01

    Drawing books can be seen as a vital component to teaching and learning art. They serve as an excellent resource for understanding the historical context of teaching drawing. As the industrial revolution geared forward in the nineteenth century, drawing books became a crucial source for sharing and disseminating educational philosophies for the…

  1. Cultural Diversity and Best Practices in the Teaching and Learning of Statistics: A Faculty Perspective from A Historically Black College/University (HBCU)

    Science.gov (United States)

    Whaley, Arthur L.

    2017-01-01

    The literature on the teaching and learning of statistics tend not to address issues of cultural diversity. Twenty-nine students enrolled in a statistics course at a historically Black college/university (HBCU) were the focus of this pilot study. Using structural equation modeling (SEM), the study tested models of the effects of writing…

  2. Mitigating the consequences of future earthquakes in historical centres: what perspectives from the joined use of past information and geological-geophysical surveys?

    Science.gov (United States)

    Terenzio Gizzi, Fabrizio; Moscatelli, Massimiliano; Potenza, Maria Rosaria; Zotta, Cinzia; Simionato, Maurizio; Pileggi, Domenico; Castenetto, Sergio

    2015-04-01

    To mitigate the damage effects of earthquakes in urban areas and particularly in historical centres prone to high seismic hazard is an important task to be pursued. As a matter of fact, seismic history throughout the world informs us that earthquakes have caused deep changes in the ancient urban conglomerations due to their high building vulnerability. Furthermore, some quarters can be exposed to an increase of seismic actions if compared with adjacent areas due to the geological and/or topographical features of the site on which the historical centres lie. Usually, the strategies aimed to estimate the local seismic hazard make only use of the geological-geophysical surveys. Thorough this approach we do not draw any lesson from what happened as a consequences of past earthquakes. With this in mind, we present the results of a joined use of historical data and traditional geological-geophysical approach to analyse the effects of possible future earthquakes in historical centres. The research activity discussed here is arranged into a joint collaboration between the Department of Civil Protection of the Presidency of Council of Ministers, the Institute of Environmental Geology and Geoengineering and the Institute of Archaeological and Monumental Heritage of the National (Italian) Research Council. In order to show the results, we discuss the preliminary achievements of the integrated study carried out on two historical towns located in Southern Apennines, a portion of the Italian peninsula exposed to high seismic hazard. Taking advantage from these two test sites, we also discuss some methodological implications that could be taken as a reference in the seismic microzonation studies.

  3. Why has Greece not defaulted, yet? - A macroeconomic and historical institutionalist perspective on why Greece has not followed in Argentine footsteps and defaulted.

    OpenAIRE

    Afranie, Lenny Matthew; Rauff Hansen, Tina; Dalgaard Steffensen, Ida

    2012-01-01

    This projects sets out to explore the reasons why Greece, in the light of the current sovereign debt crisis, has not done as Argentina did in 2001 and defaulted. It uses a historical institutionalist framework, drawing on path dependency and critical junctures in the analysis of 1. how the European Union (EU) imposes restrictions on Greece, and 2. how Greece's and Argentina's situations correspond and differ. The project concludes that the main difference lies in the restrictions imposed on G...

  4. Negotiating the Process of Historical Empathy

    Science.gov (United States)

    Endacott, Jason L.

    2014-01-01

    Historical empathy scholarship has evolved to the point where further progress necessitates empirical examinations from a variety of perspectives. Prior studies on historical empathy have largely focused on teachers' pedagogical approach and student outcomes. This qualitative study focuses on students as they engage in the process of historical…

  5. "A new lachrymal gland with an excretory duct in red and fallow deer" by Johann jacob Harder (1694): English translation and historical perspective.

    Science.gov (United States)

    Hillenius, Willem J; Phillips, Darryl A; Rehorek, Susan J

    2007-01-01

    The Harderian gland is an enigmatic orbital gland that has been described for many tetrapods, although a consistent definition of this structure has remained elusive. In particular, an unambiguous distinction between the Harderian gland and the nictitans gland, which may both occur in the anterior aspect of the orbit of mammals, remains problematic. These glands were first distinguished in 1694 by Johann Jacob Harder, a Swiss physician and anatomist. To facilitate a renewed examination of the anatomical and developmental relationships of the anterior orbital glands, we review the historical context of Harder's discovery, and provide Harder's original Latin text as well as an English translation.

  6. Historical review

    International Nuclear Information System (INIS)

    Zamora C, H.H.

    1989-01-01

    Short history of the ''Instituto de Asuntos Nucleares''. A short historical review about IAN is made: from 1956 when it was called Instituto Colombiano de Asuntos Nucleares, showing its scientific and technical development and the most important events that have occurred in the last 30 years. The people who had contributed to the progress of the institution are also considered, making emphasis in the important happenings that have guided the routes of the IAN

  7. Low-dose radiation (LDR) induces hematopoietic hormesis: LDR-induced mobilization of hematopoietic progenitor cells into peripheral blood circulation.

    Science.gov (United States)

    Li, Wei; Wang, Guanjun; Cui, Jiuwei; Xue, Lu; Cai, Lu

    2004-11-01

    The aim of this study was to investigate the stimulating effect of low-dose radiation (LDR) on bone marrow hematopoietic progenitor cell (HPC) proliferation and peripheral blood mobilization. Mice were exposed to 25- to 100-mGy x-rays. Bone marrow and peripheral blood HPCs (BFU-E, CFU-GM, and c-kit+ cells) were measured, and GM-CSF, G-CSF, and IL-3 protein and mRNA expression were detected using ELISA, slot blot hybridization, and Northern blot methods. To functionally evaluate LDR-stimulated and -mobilized HPCs, repopulation of peripheral blood cells in lethally irradiated recipients after transplantation of LDR-treated donor HPCs was examined by WBC counts, animal survival, and colony-forming units in the recipient spleens (CFUs-S). 75-mGy x-rays induced a maximal stimulation for bone marrow HPC proliferation (CFU-GM and BFU-E formation) 48 hours postirradiation, along with a significant increase in HPC mobilization into peripheral blood 48 to 72 hours postradiation, as shown by increases in CFU-GM formation and proportion of c-kit+ cells in the peripheral mononuclear cells. 75-mGy x-rays also maximally induced increases in G-CSF and GM-CSF mRNA expression in splenocytes and levels of serum GM-CSF. To define the critical role of these hematopoietic-stimulating factors in HPC peripheral mobilization, direct administration of G-CSF at a dose of 300 microg/kg/day or 150 microg/kg/day was applied and found to significantly stimulate GM-CFU formation and increase c-kit+ cells in the peripheral mononuclear cells. More importantly, 75-mGy x-rays plus 150 microg/kg/day G-CSF (LDR/150-G-CSF) produced a similar effect to that of 300 microg/kg/day G-CSF alone. Furthermore, the capability of LDR-mobilized donor HPCs to repopulate blood cells was confirmed in lethally irradiated recipient mice by counting peripheral WBC and CFUs-S. These results suggest that LDR induces hematopoietic hormesis, as demonstrated by HPC proliferation and peripheral mobilization, providing a

  8. Fatherlessness in first-century Mediterranean culture: The historical Jesus seen from the perspective of cross-cuitural anthropology and cultural psychology

    Directory of Open Access Journals (Sweden)

    Andries van Aarde

    1999-12-01

    Full Text Available In the peasant sociey of Jesus' world the family revolved around the father. The father and the mother were the source of the family, not only in the biological sense, but because their interaction with their child rencreated the structures of society. In first-century Mediterranean culture, fatherlessness led to marginalization. Seen against the background of the patriarchal mind set of Israelites in the Second Temple period, a fatherless son would have been without social identiy. He would have been debarred from being called child of Abraham (that is child of God and from the privilege of being given a daughter in marriage. He would be denied access to the court of the Israelites in the Temple. In this article, with the help of cross-cultural anthropology and cultural psychology, the life of the historical Jesus is explained in social-scientiic terms against the background of the mariage regulations determined by the Temple. The historical Jesus is seen as someone who sufered the stigma of being fatherless but who trusted God as father.

  9. Historical perspective, economic analysis, and regulatory analysis of the impacts of waste partitioning-transmutation on the disposal of radioactive wastes

    International Nuclear Information System (INIS)

    Forsberg, C.W.; Croff, A.G.; Kocher, D.C.

    1990-10-01

    Partitioning-transmutation, sometimes called actinide burning, is an alternative approach to high-level radioactive waste management. It consists of removing long-lived radionuclides from wastes and destroying those radionuclides, thus reducing the long-term hazards of radioactive waste. It was studied in detail in the 1970's. New developments in technology and other factors are resulting in a reexamination of this waste management option. This report consists of three papers which summarize the historical work, update the analysis of the costs of waste disposal, and describe current regulatory requirements which might be impacted by P-T. The papers provide a starting point for future research on P-T. 152 refs., 2 figs., 19 tabs

  10. Has epidemiology become infatuated with methods? A historical perspective on the place of methods during the classical (1945-1965) phase of epidemiology.

    Science.gov (United States)

    Morabia, Alfredo

    2015-03-18

    Before World War II, epidemiology was a small discipline, practiced by a handful of people working mostly in the United Kingdom and in the United States. Today it is practiced by tens of thousands of people on all continents. Between 1945 and 1965, during what is known as its "classical" phase, epidemiology became recognized as a major academic discipline in medicine and public health. On the basis of a review of the historical evidence, this article examines to which extent classical epidemiology has been a golden age of an action-driven, problem-solving science, in which epidemiologists were less concerned with the sophistication of their methods than with the societal consequences of their work. It also discusses whether the paucity of methods stymied or boosted classical epidemiology's ability to convince political and financial agencies about the need to intervene in order to improve the health of the people.

  11. Forming, transfer and globalization of medical-pharmaceutical knowledge in South East Asian missions (17th to 18th c.) - historical dimensions and modern perspectives.

    Science.gov (United States)

    Anagnostou, Sabine

    2015-06-05

    From the 17th to the 18th centuries, missionaries in Southeast Asia dedicated themselves to providing and establishing a professional medical-pharmaceutical supply for the local population and therefore explored the genuine Materia medica for easily available and affordable remedies, especially medicinal plants. In characteristic medical-pharmaceutical compendia, which can be classified as missionary pharmacopoeias, they laid down their knowledge to advise others and to guarantee a professional health care. As their knowledge often resulted from an exchange with indigenous communities, these compendia provide essential information about traditional plant uses of Southeast Asian people. Individual missionaries such as the Jesuit Georg Joseph Kamel (1661-1706) not only strove to explore medicinal plants but performed botanical studies and even composed comprehensive herbals. The Jesuit missionaries in particular played roles in both the order's own global network of transfer of medicinal drugs and knowledge about the application, and within the contemporary local and European scientific networks which included, for example, the famous Royal Society of London. The results of their studies were distributed all over the world, were introduced into the practical Materia medica of other regions, and contributed significantly to the academization of knowledge. In our article we will explain the different intentions and methods of exploring, the resulting works and the consequences for the forming of the pharmaceutical and scientific knowledge. Finally, we will show the options which the works of the missionaries can offer for the saving of traditional ethnopharmacological knowledge and for the development of modern phytotherapeutics and pharmaceutical supply. The publication is based on a comprehensive study on the phenomenon of missionary pharmacy which has been published as a book in 2011 (Anagnostou, 2011a) and shows now the potential of historical medical

  12. Avaliação da cultura do milho e da decomposição da palhada submetida à Hormesis

    OpenAIRE

    Sousa, Saulo Fernando Gomes de [UNESP

    2013-01-01

    Nos sistemas conservacionistas de preparo do solo é fundamental a manutenção de resíduos vegetais das culturas anteriores na superfície do solo. Em certas regiões de clima quente com alta umidade no ar, a ação dos microorganismos é mais rápida, favorecendo a decomposição acelerada. Além do fator climático, também a relação Carbono/Nitrogênio (relação C/N), influi na velocidade de decomposição, pois quanto mais baixa essa relação mais rápida é a decomposição. A técnica denominada Hormesis é ba...

  13. Experiencing the “refugee crisis” through the Intervention into the Public Discourse: Us as the Others in the Historical Perspective of Slovenian Emigration and Integration Practices

    Directory of Open Access Journals (Sweden)

    Mirjam Milharčič Hladnik

    2016-12-01

    Full Text Available In Slovenia the so called refugee crisis lasted from October 2015 to March 2016, when the Balkan route was closed. The public discourse in this time had the characteristic of moral panic; it abruptly started when the Hungarian government closed the border with Serbia and Croatia, forcing masses of migrants to take the route to “Germany” via Slovenia, and as abruptly ended with the closure of the Balkan route. The subjective experience with the period of intense public interest in migration is described through many interventions by the author, who happened to be one of the many experts who were asked to comment on the “refugee crisis”. Each intervention was intentionally the same, and addressed the same two clusters of public fears: first, the masses of migrants and refugees as a natural disaster that would destroy “everything”, and, second, the impossibility of integration of masses of migrants into European and Slovenian societies. Each intervention insisted, first, on the forgotten historical facts about the intense migrations that have been a crucial part of the formations of Europe’s ethnically, religiously, linguistically and culturally diverse and mixed populations and societies, and, second, on the forgotten facts about the recent successful integration practices that have evolved in Europe and Slovenia in the past fifty years and enabled them to become and remain economically and socially stable and safe.

  14. OBSERVATIONS (NEW AND OLD ON THE ARMED FORCES IN THE THE ATLANTIC WORLD: CURRENT AND FUTURE THREATS AND CHALLENGES IN HISTORICAL PERSPECTIVE

    Directory of Open Access Journals (Sweden)

    FREDERICK M. NUNN

    2017-12-01

    Full Text Available Confrontations with threats and challenges to the existence of governments and societies have marked the flow of time throughout history. Present and future threats associated, as they are, with historical and traditional challenge are, in many places, of such complexity that they already require new forms of relations between civilian authorities and the leadership of professional institutions dedicated to defense and security. These new relations will have to be based on an understanding of the processes of democratization and globalization as much as on the complex nature of conflicts that affect the security, sovereignty and stability of 21st century nation-states. As formidable as they appear, these threats and challenges may be considered current reiterations of others that mark our histories. In the Atlantic World, nowhere more so than in Latin America, the literature of the military profession has always demonstrated the recognition of lessons of the past applied to problems of the presentation aid in preparation for the future. A principal reason for this is that said literature is in and of itself the product of civil-military collaborations.

  15. An integrated simulation method for flash-flood risk assessment: 2. Effects of changes in land-use under a historical perspective

    Science.gov (United States)

    Rosso, R.; Rulli, M. C.

    The influence of land use changes on flood occurrence and severity in the Bisagno River (Thyrrenian Liguria, N.W. Italy is investigated using a Monte Carlo simulation approach (Rulli and Rosso, 2002). High resolution land-use maps for the area were reconstructed and scenario simulations were made for a pre-industrial (1878), an intermediate (1930) and a current (1980) year. Land-use effects were explored to assess the consequences of distributed changes in land use due to agricultural practice and urbanisation. Hydraulic conveyance effects were considered, to assess the consequences of channel modifications associated with engineering works in the lower Bisagno River network. Flood frequency analyses of the annual flood series, retrieved from the simulations, were used to examine the effect of land-use change and river conveyance on flood regime. The impact of these effects proved to be negligible in the upper Bisagno River, moderate in the downstream river and severe in the small tributaries in the lower Bisagno valley that drain densely populated urban areas. The simulation approach is shown to be capable of incorporating historical data on landscape and river patterns into quantitative methods for risk assessment.

  16. Southern Cone Initiative for the elimination of domestic populations of Triatoma infestans and the interruption of transfusion Chagas disease: historical aspects, present situation, and perspectives

    Directory of Open Access Journals (Sweden)

    João Carlos Pinto Dias

    2007-10-01

    Full Text Available Created in 1991 by the governments of Argentina, Bolivia, Brazil, Chile, Paraguay, and Uruguay, the Southern Cone Initiative (SCI has been extremely important for Chagas disease control in this region. Its basic objective was to reach the interruption of this disease, chiefly by means of the elimination of the principal vector Triatoma infestans and by the selection of safe donors in the regional blood banks. After a summarized historic of SCI, the text shows the advance of technical and operative activities, emphasizing some factors for the initiative success, as well as some difficulties and constraints. The future of SCI will depend of the continuity of the actions and of political priority. Scientific community has been highly responsible for this initiative and its maintenance. At the side of this, national and international efforts must be involved and reinforced to assure the accomplishment of the final targets of SCI. Very specially, the Pan American Health Organization has cooperated with the Initiative in all its moments and activities,being the most important catalytic and technical factor for SCI success.

  17. Surrendering to the Big Picture: Historical and Legal Perspectives on Accountability in the Democratic Republic of Congo Following the Defeat of the March 23 Movement

    Directory of Open Access Journals (Sweden)

    Janet McKnight

    2014-02-01

    Full Text Available It remains to be seen whether the past few months will mark a genuine turning point in the conflict in eastern Democratic Republic of Congo (DRC, as the rebel faction March 23 Movement (M23 announced the end of its 20-month insurgency against the government on 5 November 2013. News of the rebel group’s surrender following its political and military defeat signals an important moment of hope and renewed prospects of peace and stability in a region prone to protracted armed conflict. However, long-term stability in the country and in the region will require a multi-faceted process consisting of comprehensive accountability for human rights violations that have been committed by all parties to the conflict. In this article, I will first lay out the historical context of the fighting and the root causes of conflict present long before M23’s entrance onto the scene as a splintered rebel faction so as to understand M23’s place within the country’s history of protracted violence. Next, I will explain the violations of international humanitarian and human rights law committed by all possible parties, including rebel and government groups, as well as individual criminal responsibility and corporate liability. Lastly, I will chart the pathways of criminal and social accountability at various levels of international and domestic justice systems to see how the DRC may continue to build long-term local stability in the eastern parts of the country by addressing the question of accountability for international crimes. This brief analysis aims to provide a broader understanding of a complex conflict beyond the defeat and disarmament of M23, albeit a key group in a region of contentious cross-border conflict.

  18. Democratização da governança global: perspectivas históricas mundiais Democratizing global governance: world historical perspectives

    Directory of Open Access Journals (Sweden)

    Christopher Chase-Dunn

    2013-04-01

    Full Text Available Este artigo examina a controversa noção de democracia global. O texto apresenta uma perspectiva histórica mundial da evolução da governança global - como a estrutura política do sistema-mundo evoluiu ao longo dos últimos séculos - e analisa movimentos sociais contemporâneos que buscam democratizar as instituições de governança global. Argumenta-se que os que desejam democratizar a governança global devem assumir o repto de ajudar a promover a construção de um estado mundial globalmente multilateral para fazer frente aos desafios que se colocarão à humanidade no século 21. Movimentos sociais transnacionais e estados nacionais semiperiféricos progressistas são vistos como os agentes que irão desafiar os poderes constituídos e conduzir a humanidade rumo a uma comunidade global democrática e coletivamente racional nas próximas décadas.This article examines the contested idea of global democracy. It presents a world historical view of the evolution of global governance - how the political structure of the world-system has evolved of over the past several centuries - and it examines contemporary social movements that are seeking to democratize global governance institutions. It is argued that those who want to democratize global governance must take up the problem of helping to further construct a global multilateral world state in order that the challenges that humanity has created for itself may be met in a collectively rational, sustainable and humane manner in the 21st century. Transnational social movements and progressive semiperipheral national-states are seen as the agents that will challenge the powers that be and move humanity closer to a democratic and collectively rational global commonwealth in the next several decades.

  19. Plants as De-Worming Agents of Livestock in the Nordic Countries: Historical Perspective, Popular Beliefs and Prospects for the Future

    Directory of Open Access Journals (Sweden)

    Ingebrigtsen K

    2001-03-01

    Full Text Available Preparations derived from plants were the original therapeutic interventions used by man to control diseases (including parasites, both within humans and livestock. Development of herbal products depended upon local botanical flora with the result that different remedies tended to develop in different parts of the world. Nevertheless, in some instances, the same or related plants were used over wide geographic regions, which also was the result of communication and/or the importation of plant material of high repute. Thus, the Nordic countries have an ancient, rich and diverse history of plant derived anthelmintic medications for human and animal use. Although some of the more commonly used herbal de-wormers were derived from imported plants, or their products, many are from endemic plants or those that thrive in the Scandinavian environment. With the advent of the modern chemotherapeutic era, and the discovery, development and marketing of a seemingly unlimited variety of highly efficacious, safe synthetic chemicals with very wide spectra of activities, herbal remedies virtually disappeared from the consciousness – at least in the Western world. This attitude is now rapidly changing. There is a widespread resurgence in natural product medication, driven by major threats posed by multi-resistant pest, or disease, organisms and the diminishing public perceptions that synthetic chemicals are the panacea to health and disease control. This review attempts to provide a comprehensive account of the depth of historical Nordic information available on herbal de-wormers, with emphasis on livestock and to provide some insights on potentially rewarding areas of "re-discovery" and scientific evaluation in this field.

  20. Usos e significados do conhecimento histórico em estudos organizacionais: uma (releitura do taylorismo sob a perspectiva do poder disciplinar Uses and meanings of historical knowledge in organizational studies: a (rereading of Taylorism from the disciplinary power perspective

    Directory of Open Access Journals (Sweden)

    Eloisio Moulin de Souza

    2013-03-01

    Full Text Available O objetivo deste artigo é problematizar - por meio da ampliação dos usos e significados do conhecimento histórico proposta pela perspectiva da nova história e pela genealogia de Michel Foucault - abordagens de estudos organizacionais mais convencionais que assumem como objeto de pesquisa os grandes feitos de grandes homens da história da Administração. Nesse sentido, tem-se: (1 como foco principal de análise uma releitura da versão legitimada do taylorismo como acontecimento histórico diretamente responsável por um conjunto de preceitos e técnicas de racionalização do trabalho; e (2 como argumento central a premissa de que as "subversões" epistemológicas da história renovada e da genealogia possibilitam-nos ler esse acontecimento com outras lentes e identificar a obra de F. W. Taylor como inserida em um conjunto maior de práticas sociais disciplinadoras. Para alcançar esse propósito, o texto está organizado em três partes. Na primeira parte, expõe-se o significado de história para Michel Foucault, em seguida, analisa-se o movimento da história nova e suas convergências com a proposta de conhecimento histórico da genealogia. Por fim, na terceira parte, o taylorismo é repensado e analisado à luz da sociedade disciplinar.This paper aims to discuss - by expanding the uses and meanings of historical knowledge as proposed from the new history perspective and by Michel Foucault's genealogy - approaches of more conventional organizational studies which take as research object the great deeds of great men in the management history. In this sense, one has: (1 as the main focus of analysis a re-reading of the legitimate version of Taylorism as a historical event directly responsible for a set of precepts and techniques of work rationalization; and (2 as the central argument the premise that epistemological "subversions" of renewed history and genealogy allow us to read this event through other lenses and identify the work of F

  1. Hormesis with ionizing radiation

    International Nuclear Information System (INIS)

    Luckey, T.D.

    1982-01-01

    This article reviews a book which summarizes and classifies more than 1250 references to experimental work with low-level radiation between 1898 and 1977; explains that the detailed material is presented in tabular form with type of radiation as the primary classification and type of organism and date of report as subclassifications; notes that an incredible variety of effects are specified for flora and fauna; praises the summaries of background radiation and of overall radiation-dose effects to a variety of organisms; and emphasizes the importance of information dealing with the public perception of radiation and its effects

  2. Hormesis: Fact or fiction?

    International Nuclear Information System (INIS)

    Holzman, D.

    1995-01-01

    Bernard Cohen had not intended to foment revolution. To be sure, he had hoped that the linear, no-threshold (LNT) model of ionizing radiation's effects on humans would prove to be an exaggeration of reality at the low levels of radiation that one can measure in humans throughout the United States. His surprising conclusion, however, was that within the low dose ranges of radiation one receives in the home, the higher the dose, the less chance one had of contracting lung cancer. 1 fig., 1 tab

  3. Historical prologue

    International Nuclear Information System (INIS)

    Ball, D.; Bethe, H.A.; Blair, B.G.; Bracken, P.; Carter, A.B.; Dickinson, H.; Garwin, R.L.; Holloway, D.; Kendall, H.W.

    1988-01-01

    The organizations and machines engaged in a severe nuclear crisis would be its tangible and partially quantifiable factors. For that reason they often dominate our thinking about superpower confrontations. Military organizations, however, are not automatons that can run amok on their own. The perceptions of leaders and populations propel the course of events, and their mindsets are shaped by what experience, history, and myth claim to say about war. Since there has never been combat between nuclear-armed states, it is debatable whether the past has any relevance to what we now face. But the part is all we have to go on. Thus soldiers and statesmen are still haunted by the manner in which this century's two great wars began, and the past thereby influences the thoughts that lead to weapons, to military plans, and to decisions that could turn peace into war. It is therefore essential to have some appreciation for the historical roots that nourish our expectations about international conflict. This paper describes some of these roots

  4. THE SCIENCE OF SCIENCE (NAUKOZNAWSTWO) IN POLAND: THE CHANGING THEORETICAL PERSPECTIVES AND POLITICAL CONTEXTS--A HISTORICAL SKETCH FROM THE 1910S TO 1993.

    Science.gov (United States)

    Kokowski, Michał

    2015-01-01

    The article sketches the history of naukoznawstwo (literally meaning the science connoisseurship or the science of science or science studies) in Poland from the 1910s to the end of the Cold War (1991), and the recovery of full political independence in 1993. It outlines the changing research perspectives of this interdisciplinary field of knowledge in Poland against a background of changing political conditions caused by the reconfigurations of the political order. The first part of the article concerns the period from the 1910s, when Poland was occupied by Russia, Prussia, and Austria, through the regaining of independence by Poland in 1918, the reconstruction of the state in 1918-1939; the second part--World War II; the third part--the period from the initial period of Soviet dominance (1944-1954) in Poland and simultaneously the beginnings of the Cold War (1947-1954), the period 1955-1956 (when the Polish state was liberated from Sovietization), through the different political crises in October 1956, March 1968, December 1970, and June 1976, to the emergence of the Independent Self-governing Trade Union Solidarity in September 1980, the end of the Cold War (1991), and the recovery of full political independence in 1993. The article outlines the fundamental achievements of prominent Polish scholars (among others K. Twardowski, M. Ossowska, S. Ossowski, T. Kotarbiński, K. Ajdukiewicz, S. Michalski, F. Znaniecki, B. Suchodolski, L. Fleck, M. Choynowski, Z. Modzelewski, S. Amsterdamski), politicians (among others B. Bierut, E. Krasowska), politicians and scholars (H. Jabłoński, S. Kulczyński), as well as committees (among others the Academic Section of the Józef Mianowski Fund, The Science of Science Committee of the Polish Academy of Sciences), schools of thought (among others the Lvov-Warsaw School of Philosophy), and academic units (among others the Science of Science Seminar in Kraków, the Department for the History of Science and Technology of the Polish

  5. Some notes on a historical perspective of panic disorder Algumas notas sobre uma perspectiva histórica do transtorno de pânico

    Directory of Open Access Journals (Sweden)

    Antonio Egidio Nardi

    2006-01-01

    Full Text Available This article aims to describe important points in the history of panic disorder concept, as well as to highlight the importance of its diagnosis for clinical and research developments. Panic disorder has been described in several literary reports and folklore. One of the oldest examples lies in Greek mythology - the god Pan, responsible for the term panic. The first half of the 19th century witnessed the culmination of medical approach. During the second half of the 19th century came the psychological approach of anxiety. The 20th century associated panic disorder to hereditary, organic and psychological factors, dividing anxiety into simple and phobic anxious states. Therapeutic development was also observed in psychopharmacological and psychotherapeutic fields. Official classifications began to include panic disorder as a category since the third edition of the American Classification Manual (1980. Some biological theories dealing with etiology were widely discussed during the last decades of the 20th century. They were based on laboratory studies of physiological, cognitive and biochemical tests, as the false suffocation alarm theory and the fear network. Such theories were important in creating new diagnostic paradigms to modern psychiatry. That suggests the need to consider a wide range of historical variables to understand how particular features for panic disorder diagnosis have been developed and how treatment has emerged.O objetivo deste artigo é descrever alguns pontos importantes na história do desenvolvimento do conceito de transtorno de pânico e ressaltar a importância do diagnóstico para o progresso da pesquisa e da clínica. O transtorno de pânico foi descrito em vários textos literários e folclóricos. Talvez um dos exemplos mais antigos seja o deus Pan da mitologia grega, responsável pelo termo pânico.Aprimeira metade do século XIX presenciou o apogeu do processo de abordagem médica. Durante a segunda metade do s

  6. A swinging seesaw as a novel model mechanism for time-dependent hormesis under dose-dependent stimulatory and inhibitory effects: A case study on the toxicity of antibacterial chemicals to Aliivibrio fischeri.

    Science.gov (United States)

    Sun, Haoyu; Calabrese, Edward J; Zheng, Min; Wang, Dali; Pan, Yongzheng; Lin, Zhifen; Liu, Ying

    2018-08-01

    Hormesis occurs frequently in broadly ranging biological areas (e.g. plant biology, microbiology, biogerontology), toxicology, pharmacology and medicine. While numerous mechanisms (e.g. receptor and pathway mediated pathway responses) account for stimulatory and inhibitory features of hormetic dose responses, the vast majority emphasizes the inclusion of many doses but only one timepoint or use of a single optimized dose that is assessed over a broad range of timepoints. In this paper, a toxicity study was designed using a large number of properly spaced doses with responses determined over a large number of timepoints, which could help us reveal the underlying mechanism of hormesis. We present the results of a dose-time-response study on hormesis using five antibacterial chemicals on the bioluminescence of Aliivibrio fischeri, measuring expression of protein mRNA based on quorum sensing, simulating bioluminescent reaction and analyzing toxic actions of test chemicals. The findings show dose-time-dependent responses conforming to the hormetic dose-response model, while revealing unique response dynamics between agent induced stimulatory and inhibitory effects within bacterial growth phase dynamics. These dynamic dose-time features reveal a type of biological seesaw model that integrates stimulatory and inhibitory responses within unique growth phase, dose and time features, which has faultlessly explained the time-dependent hormetic phenomenon induced by five antibacterial chemicals (characterized by low-dose stimulation and high-dose inhibition). This study offers advances in understanding cellular dynamics, the biological integration of diverse and opposing responses and their role in evolutionary adaptive strategies to chemicals, which can provide new insight into the mechanistic investigation of hormesis. Copyright © 2018 Elsevier Ltd. All rights reserved.

  7. Paradigmenwechsel in der Anti-Aging-Medizin: Hormesis, Target-of-Rapamycin-Komplex und erste Anti-Aging-Pillen // Paradigm Shift in Anti-Aging Medicine: Hormesis, Target of Rapamycin Complex and First Human Anti-Aging-Pills

    Directory of Open Access Journals (Sweden)

    Römmler A

    2016-01-01

    dieser Gesellschaften. Manche Maßnahmen der Lebensführung (z. B. kalorienreduzierte Ernährung, regelmäßiges Training verbessern die Altersgesundheit, dennoch benötigen viele zusätzlich Therapien gegen Krankheiten im Alter. Deren größter Risikofaktor ist „das Altern“ selbst.brIn Tiermodellen können durch bestimmte Substanzen und Lebensführung die gesunde Lebensspanne verlängert und das Altern verzögert werden. Dies wird durch physiologische Signalketten vermittelt, die evolutionär konserviert erscheinen. Im Mittelpunkt solcher Regulatoren steht der mTOR-Komplex („mechanistic Target of Rapamycin“. Er verknüpft Signale wie Energie-, Nahrungs- und Stressstatus mit grundlegenden Aktivitäten der Zelle, zu denen Proliferation versus Zellarrest sowie Reparatur versus Apoptose gehören.brDie Zellregulation auf solche Signale bzw. Stressoren erfolgt nicht linear, sondern biphasisch (U-förmig, glockenförmig als hormetisches Prinzip. Demnach führen milde Stress-Dosen zunächst zur Aktivierung von Reparatursystemen, womit sich die Zelle an solche „giftigen“ Reize adaptiert und widerstandsfähiger wird. Erst bei höheren Reizen kommt es zum Umkehreffekt und zu toxischer Schädigung. „Hormesis“ beschreibt plausibel die in Modellorganismen beobachteten Anti-Aging-Effekte solcher milden Reize, die sich durch verlängerte Lebensspanne bei verminderter Krankheitsinzidenz (Diabetes mellitus, Karzinome, Demenz auszeichnen.brEinige natürliche mTOR-Inhibitoren sind für humane Anwendungen bereits verfügbar. Hierzu zählen Resveratrol, Rapamycin (Sirolimus und Metformin, die von Bakterien, Pilzen oder Pflanzen jeweils als „Giftstoffe“ zur Abwehr von Fressfeinden gebildet werden. Erste Humandaten bei Diabetikern unter Metformin und bei Älteren mit Immunseneszenz unter Rapamycin zeigen bereits Anti-Aging-Effekte, was neue Perspektiven für die Altersmedizin eröffnet.

  8. POSIBILIDADES Y LÍMITES DE LA UNIVERSIDAD LATINOAMERICANA DESDE UNA PERSPECTIVA HISTÓRICA POSSIBILITIES AND LIMITS OF THE LATIN AMERICAN UNIVERSITY FROM A HISTORICAL PERSPECTIVE

    Directory of Open Access Journals (Sweden)

    Claudia Milena Jaramillo

    2011-06-01

    German, and the American people. Despite the interests which hang over the Latin American university, from diverse glances (the experiences of Mexico, Peru, Guatemala, Argentina, Chile, and Colombia appear possibilities of considering the idea of restructuring an individual thinking which could recount a different identity that separates it from the Euro-centered discourse and places it in a perspective of analysis concerning the realities it has to deal with. In the configuration of the Latin American University, the following can stand out: Andrés Bello’s thought, José Vasconcellos’ ideas, and the implications of the Movement of Cordoba, as for the social and student movements with similar characteristics, which are directed toward the reflection about the need of making a decolonized change, not just as a matter of resistance, but of self-awareness of who we are and how to strengthen a common future. This is especially done in this epoch when the Latin American University is facing the attacks of globalization and the application of macro-economic policies that blur its social and academic being, undermining it.

  9. O desenvolvimento do marketing: uma perspectiva histórica El desarrollo del marketing: una perspectiva histórica The evolution of marketing: an historical perspective

    Directory of Open Access Journals (Sweden)

    Tatiani Santos

    2009-03-01

    y dividimos su historia en décadas, comenzando en el año de 1900 y llegando hasta los días actuales, con el intuito de presentar el surgimiento de las diferentes escuelas de pensamiento, el desarrollo de nuevas actividades, el Marketing dentro de las organizaciones y su diferenciación en actividades específicas como el Marketing “Societal” y el Marketing “Experiencial”. Además de eso, buscamos remontar también a la historia del Marketing en Brasil, resaltando sus principales marcos evolutivos. Por fin, son presentadas algunas contribuciones de otras áreas del conocimiento y ciencias, así como los problemas vivenciados por el Marketing.For a better understanding of marketing and its growing importance in organizations, this work provided a detailed view of the historical evolution of marketing, from a time when it was not yet considered a specific area, up to the present day. The early history of marketing included activities that were developed only as trade practices. After 1900, marketing activities differed from the practices of trade, with the emergence of Marketing as a distinct domain. So from 1900, the history was divided into decades until now to show the emergence of the different schools of thought, the development of new activities, marketing inside organizations as well as the differentiation into the specific activities of Societal Marketing and Experience Marketing. Further, the history of marketing in Brazil was revisited emphasizing important milestones. Finally, some contributions from other areas of knowledge and sciences as well as problems experienced by Marketing are mentioned.

  10. National Register Historic Districts

    Data.gov (United States)

    Iowa State University GIS Support and Research Facility — The National Register Historic District layer is a shape file showing the boundaries of Historic Districts that are listed on the National Register of Historic Places.

  11. Una perspectiva histórica y comparada sobre la Contraloría General de la República del Chile / A historic and comparative perspective on the Office of the Comptroller General of the Republic of Chile

    Directory of Open Access Journals (Sweden)

    Iván Mauricio Obando Camino

    2016-07-01

    Full Text Available Resumen: Este artículo explora el desarrollo constitucional y legal de la Contraloría General de la República de Chile, considerando una perspectiva histórica y comparada. Tras referirse a sus orígenes legales en 1927, este artículo discurre sobre las razones que presidieron su constitucionalización en 1943 y 1980, lo que ha llevado a hacer de ella un órgano de control administrativo autónomo, en casi todos sus aspectos, en el sistema político chileno. Así también queda de manifiesto cuando ella es comparada con órganos de control administrativo semejantes existentes en la región, lo que permite visualizar la singularidad de aquélla. Palabras clave: Contraloría; control; fiscalización.    Abstract: This article explores the constitutional and legal development of the Office of the Comptroller General of the Republic of Chile taking into account both a historic and comparative perspective. After dwelling on the legal origins of this agency back in 1927, this article deals with the reasons that presided over the writing of this agency into the Chilean constitution both in 1943 and 1980, which gave way to an almost autonomous agency of administrative oversight in the Chilean political system. The latter stands out after comparing this agency with similar offices that exist in the region, which points out to the distinctiveness of the aforementioned agency. Keywords: Comptroller; control; oversight.

  12. O brincar de uma criança autista sob a ótica da perspectiva histórico-cultural An autistic child's play from the cultural-historical perspective

    Directory of Open Access Journals (Sweden)

    Maria Fernanda Bagarollo

    2013-03-01

    historical-cultural perspective of human development - which conceives of subjects as social beings, culturally constituted in and through language - this statement is no longer sustainable, since play is a socially constituted activity. From this standpoint, this study aimed to analyze the peculiarities of play in a child with autism, immersed in rich experiences with other children, with toys and games. Data collection was carried out using video recordings of speech therapy sessions with a group of four autistic children. The focus was on one child's play activities (S1, four years. The recordings were transcribed and data was analyzed based on the microgenetic analysis perspective. The data showed that when autistic children experience positive social interactions, it is possible to develop play, imaginative processes and sequences of actions such as those observed in the group's social and cultural use of toys. We conclude that therapist intervention is critical during the interaction process, assigning meanings to the child's actions, enabling the possibility of constitution of cultural being and of interacting with others. This process helps build the basis for internalizations derived from playing with others. As observed, experiences outside the institution provided opportunities to play and develop during the process, albeit more slowly and more specifically.

  13. Course Descriptions in Environmental Studies Part One: Historical Courses.

    Science.gov (United States)

    Hughes, Donald; And Others

    1984-01-01

    Presents descriptions (syllabi, outlines, goals) of selected environmental studies courses which approach the discipline from an historical and humanistic perspective. Areas explored in the courses include human ecology, American environmental history, environmental politics, and others. (JN)

  14. Hormesis of specific IgG antibody to rabies virus in serum of mice irradiated with low dose γ-rays

    International Nuclear Information System (INIS)

    Liu Qingjie; Chen Deqing

    1998-01-01

    Objective: To explore the effect of low dose ionizing radiation on specific antibody in mouse serum. Methods: Kunming strain male mice, weighing 18-22 g, aged 6-8 weeks, were immunized intraperitoneally with rabies vaccine after exposure to cobalt-60 γ-rays. The specific IgG antibody against rabies virus in mouse serum was measured. Results: (1) The serum levels of specific IgG in mice irradiated with 5-30 cGy γ-rays were significantly elevated in comparison with those in control mice (P<0.01), the optimum stimulating dose being 10 cGy. (2) Exposure to 10 cGy caused significant enhancement and earlier emergence of the peak level of specific IgG in serum. (3) The hormesis of specific IgG to rabies virus induced by 10 cGy γ-rays could last one week at least. Conclusion: Low dose ionizing radiation can enhance the level of specific antibody in mouse serum, and this effect can last for one week at least

  15. Typography in Media Historical Perspective. An Introduction

    NARCIS (Netherlands)

    Post, Jack; Lentjes, Ewan

    2017-01-01

    textabstractEditorialAt first glance, a special issue on the subject of typography might seem an unusual choice for an academic journal dedicated to media history. After all, wouldn’t the study of typography be better suited to a publication on the history of art and graphic design, or perhaps the

  16. Photography and sustainability in historical perspective

    NARCIS (Netherlands)

    Monte, A.; Roeling, M.M.; Reijenga, J.C.

    2007-01-01

    Photography exists since the early 1800's. This book gives an overview of sustainability of photography during the past 200 years. Both the (chemistry of the) image carrier and photo camera's are treated. While the former has shown consistent improvements, the latter has displayed rapid

  17. Nelson syndrome: historical perspectives and current concepts.

    Science.gov (United States)

    Hornyak, Mark; Weiss, Martin H; Nelson, Don H; Couldwell, William T

    2007-01-01

    The appearance of an adrenocorticotropic hormone (ACTH)-producing tumor after bilateral adrenalectomy for Cushing disease was first described by Nelson in 1958. The syndrome that now bears his name was characterized by hyperpigmentation, a sellar mass, and increased plasma ACTH levels. The treatment of Cushing disease has changed drastically since the 1950s, when the choice was adrenalectomy. Thus, the occurrence, diagnosis, and treatment of Nelson syndrome have changed as well. In the modern era of high-resolution neuroimaging, transsphenoidal microneurosurgery, and stereotactic radiosurgery, Nelson syndrome has become a rare entity. The authors describe the history of the diagnosis and treatment of Nelson syndrome. In light of the changes described, the authors believe this disease must be reevaluated in the contemporary era and a modern paradigm adopted.

  18. Historical perspectives on health. Early Arabic medicine.

    Science.gov (United States)

    Brewer, Harry

    2004-07-01

    The Arabian conquests during and after the 7th century led to a spread of Islam as well as the consequential influence of theology on health through the teachings of the Qur'an (Koran). Although traditional medicine was widely accepted and used, the character of early aggrandisement of Arabic medicine involved a facility for adapting and absorbing Graeco-Roman knowledge. The translation schools and libraries, famous in both the East and West, preserved and expanded the knowledge acquired. European academic learning owed much to the Arabs. Information came through Spain to Italy, France and, later on, England. The founding of hospitals, whilst not an Arab initiative, received a fillip from the religious prescriptions for care of the sick. The Military Orders developed specialist institutions for the sick, probably as a result of what they saw during their sojourn in the Middle East. The legacy of Arabic medical care is still with us today and deserves understanding and greater appreciation.

  19. Einstein and general relativity: historical perspectives

    International Nuclear Information System (INIS)

    Chandrasekhar, S.

    1978-01-01

    The place of Einstein in 20th-century physics is discussed. The basic ideas that led Einstein to his theory of gravitation by the sheer power of speculative thought are described in the most general terms. The prediction of the bending of starlight by the Sun and the eclipse expedition of 1919 are recounted. The author feels that ''the general theory of relativity is incredibly rich in its content;...one finds a glittering face at almost every turn.'' The prediction of black holes by general relativity is noted

  20. Optometry in Portugal: a historical perspective

    Science.gov (United States)

    Teixeira, Eduardo; Baptista, António M. G.; Sousa, Raul A. R. C.

    2011-05-01

    The establishment and development of optometry in Portugal resulted from the committed work of many individuals and institutions. These efforts have had good results in terms of raising the public's awareness of the major role played by optometrists in primary eye care. Back in the late 80's higher education in optometry was started. Ten years ago the results of scientific research on the topic first became available and are now also contributing to the success of optometry in Portugal. In regard to the optometry profession, specific regulations are to be discussed in the national parliament. The Associação de Profissionais Licenciados de Optometria (APLO), as the professional organization representing optometrists in Portugal, has been critically important in this process. This article will present an overview of the history of optometry in Portugal, of change in the foreseeable future and of the APLO's experience and activities.

  1. Evolution of nuclear medicine: a historical perspective

    International Nuclear Information System (INIS)

    Ahmed, A.; Kamal, S.

    1996-01-01

    The field Nuclear Medicine has Completed its 100 yeas in 1996. Nuclear medicine began with physics, expanded into chemistry and instrumentation, and then greatly influenced various fields of medicine. The chronology of the events that formulated the present status of nuclear medicine involves some of the great pioneers of yesterday like Becquerel, Curie, Joliot, Hevesy, Anger, Berson and Yallow. The field of nuclear medicine has been regarded as the bridge builder between various aspects of health care and within next 20 years, nuclear medicine enters a new age of certainty, in which surgery, radiation and chemotherapy will only be used when a benefit in certain to result from the treatment. (author)

  2. Diversity research from a historical perspective

    DEFF Research Database (Denmark)

    Ottsen, Christina Lundsgaard

    2018-01-01

    into the workforce. Their collaborative style made human relations central in a way that challenged existing norms. This and other improvements in gender equality during the last century have opened the possibility of high-position jobs for women, but progress in gender balance at the C-suite level remains slow...

  3. Neurology Of Hysteria - A Historical Perspective

    Directory of Open Access Journals (Sweden)

    Chakravarty Ambar

    2001-01-01

    Full Text Available The Present article summarises the changing concepts about hysteria from Egyptian papyrus to early 20th century. The contributions of early physicians including Charcot and his pupils in developing bedside clinical methods to differentiate organic disease from hysterical conversion have been highlighted. Various forms of therapy used over several centuries for this fascinating disorder is also discussed.

  4. An historical review and perspective of AINSE

    Energy Technology Data Exchange (ETDEWEB)

    Ophel, T.R. [Australian National University, Canberra, ACT, (Australia). Department of Nuclear Physics

    1998-12-31

    Full text: ANSTO was formed in 1958 as a cooperative venture of modest scope, involving the newly established AAEC (created by the Atomic Energy Act of 1953 with facilities at Lucas Heights being formally opened in 1955) and the eight universities that existed at the time. Research emphasis was very much nuclear, with the two reactors MOATA and HIFAR and possible future nuclear energy developments defining it. Two accelerators, added in the early sixties - the 3 MV Van de Graaff and the 1.3 MV electron machine, were to sustain those original activities of the AAEC. It would probably be true to say that AINSE in those early days placed much importance on the general support of nuclear science throughout Australia, whereas now of course the facilitation of the use of ANSTO facilities has become the main function. Thereafter, both AINSE and the AAEC have undergone dramatic change. The number of universities expanded to 19 in the late sixties, along with more support and encouragement for research at both the new institutions and the original group of eight. University use of Lucas Heights facilities, through the agency of AINSE, expanded and began to diversify somewhat into other disciplines - a trend that has continued apace ever since. In the nineties, the Dawkins revolution led to a doubling of the number of tertiary institutions, so that once again AINSE experienced a quantum jump in size, with of course matching complexity. In parallel, AAEC broadened its activities to embrace a wide range of nuclear and energy related areas, though basic research began to taper off. Finally, the organization was given a new charter in 1985 and re-named ANSTO. A much expanded university system, the `new` ANSTO, the rise of economic rationalism and the creation of the Australian Research Council have combined to provide a succession of challenges to AINSE. From the original small, club-like beginning with narrow interests, AINSE has emerged with more than a four-fold increase in membership, to foster research within almost all of the Faculties of those members

  5. Einstein and General Relativity: Historical Perspectives.

    Science.gov (United States)

    Chandrasekhar, S.

    1979-01-01

    This paper presented in the 1978 Oppenheimer Memorial Lecture at Los Alamos Scientific Laboratories on August 17, 1978, discusses Einstein's contributions to physics, in particular, his discovery of the general theory of relativity. (HM)

  6. EUV lithography : historical perspective and road ahead

    NARCIS (Netherlands)

    Banine, V.Y.

    2014-01-01

    Lithography, in the form of carved type printing, can be dated as far back as the 3rd century AD. Starting from the 19th century it played a major role as the basis for dissemination and preservation of knowledge in the form of printed books, maps, newspapers, etc. In the mid 20th century, with the

  7. The Moro Problem: An Historical Perspective

    Science.gov (United States)

    1985-06-01

    Contemporary Problems (Manila: Solidaridad Publishing House, 1974), p. 187. 1 2 Majul, Cesar Adib., Muslims in the Philippines (Manila: St. Mary’s Publishing...Rcbert D. McAmis (eds.), The Muslim Filipinos: Their History, Society and Contemporary Problems (Manila: Solidaridad Publishing House, 1974), p. 271. 17...Filipinos: Their History, Society, and Contemporary Problems (Manila: Solidaridad Publishing House, 1974), p. 246. 117 :4 S. N N I , •..- t 2 9 Wulff

  8. A Historical Perspective from "a" to "c"

    Science.gov (United States)

    Edwards, Thomas G.; Ozgun-Koca, S. Asli

    2010-01-01

    Evolving technology has played an important part in a common quadratic-function lesson. Having been mentioned repeatedly in numerous reform documents, a recurring lesson has involved changing the parameters in f(x) = ax[superscript 2] + bx + c and studying the effects on the graph. In both NCTM Yearbooks and NCTM Standards documents, technology is…

  9. Parasites in Forensic Science: a historic perspective

    Science.gov (United States)

    Cardoso, Rita; Alves, Helena; Richter, Joachim; Botelho, Monica C

    Parasites show a great potential to Forensic Science. Forensic Science is the application of any science and methodology to the legal system. The forensic scientist collects and analyses the physical evidence and produce a report of the results to the court. A parasite is an organism that lives at the expense of another and they exist in any ecosystem. Parasites are the cause of many important diseases. The forensic scientists can use the parasites to identify a crime scene, to determine the murder weapon or simply identify an individual. The applications for parasites in the Forensic Science can be many and more studies should be made in Forensic Parasitology. The most important parasites in Forensic Science are helminths specifically schistosomes. Through history there are many cases where schistosomes were described in autopsies and it was related to the cause of death. Here we review the applications of parasites in Forensic Science and its importance to the forensic scientist.

  10. Offshoring in the Semiconductor Industry: Historical Perspectives

    OpenAIRE

    Brown, Clair; Linden, Greg

    2005-01-01

    Semiconductor design is a frequently-cited example of the new wave of offshoring and foreign-outsourcing of service sector jobs. It is certainly a concern to U.S. design engineers themselves. In addition to the current wave of white-collar outsourcing, the industry also has a rich experience with offshoring of manufacturing activity. Semiconductor companies were among the first to invest in offshore facilities to manufacture goods for imports back to the U.S. A brief review of these earlie...

  11. Historical perspective: eponyms of vascular radiology.

    Science.gov (United States)

    DiPoce, Jason; Jimenez, Guillermo; Weintraub, Joshua

    2014-01-01

    Eponyms are ubiquitous throughout the medical literature, especially the radiology lexicon. In particular, vascular radiology is replete with dozens of eponyms named after pathologic and anatomic features and various medical devices. Several disease processes are known exclusively by their eponyms or by both their eponyms and their descriptive names. Although some authors advocate abandoning eponyms in favor of more descriptive terms, the established history and common use of eponyms make it unlikely that they will disappear from the vocabulary. Radiologists should be familiar with both the eponymous and descriptive names of disease processes to ensure effective communication and prevent erroneous identification. Study of these eponyms provides information about these disease processes and other medical knowledge for use in daily practice. In addition, biographic information about the pertinent physicians can yield insights into the sometimes surprising origins of these eponyms. The authors provide biographic sketches of these physicians and discuss the clinical relevance of the anatomic features, malformations, and syndromes that bear their names. ©RSNA, 2014.

  12. Exercise is medicine: a historical perspective.

    Science.gov (United States)

    Berryman, Jack W

    2010-01-01

    Much of the early information about exercise and medicine appeared in the ancient, medieval, and Renaissance medical literature in the context of the "six things nonnatural." These were the things that were under everyone's own control, directly influenced health, and became the central part of the new "physical education" movement in the early 19 century in the United States. They were known then as the "Laws of Health." Until the early 1900s, "physical education" was dominated by physicians who specialized in health and exercise. However, physical education changed to a games and sports curriculum led by coaches who introduced competition and athletic achievement into the classroom. As that happened, physicians disappeared from the profession. Through the last half of the twentieth century, as exercise became more central to public health, the medical community began to view exercise as part of lifestyle, a concept embracing what was once called the "six things nonnatural."

  13. Overview of Drosophila immunity: a historical perspective.

    Science.gov (United States)

    Imler, Jean-Luc

    2014-01-01

    The functional analysis of genes from the model organism Drosophila melanogaster has provided invaluable information for many cellular and developmental or physiological processes, including immunity. The best-understood aspect of Drosophila immunity is the inducible humoral response, first recognized in 1972. This pioneering work led to a remarkable series of findings over the next 30 years, ranging from the identification and characterization of the antimicrobial peptides produced, to the deciphering of the signalling pathways activating the genes that encode them and, ultimately, to the discovery of the receptors sensing infection. These studies on an insect model coincided with a revival of the field of innate immunity, and had an unanticipated impact on the biomedical field. Copyright © 2013 Elsevier Ltd. All rights reserved.

  14. Family in historical and regional perspective

    Directory of Open Access Journals (Sweden)

    Tripković Gordana D.

    2002-01-01

    Full Text Available In this article author gives try to provide a frame suitable for researches of regional and multicultural characteristics of family, specially in Vojvodina region. Starting with the thesis that there is no perfect analytical model to be applied in investigation of regionalization and multiculturality, for the gap between monocultural and multicultural epistemology could not be bridged over, author is paying attention to the opportunities for regionalization to pervert in regionalism in the sense of ideology and policy that neglect specific regional needs of family. This dispels a negative consequences concerning the self development of the family as a very reason for regionalization to be accomplished. In spite of attractive ideas that regionalization is addressed to, regionalization of this kind realizes on the matrix above, of deciding 'in the people's name'. In this fashion regionalization is followed with the violence and confrontations as probable outcomes of changes within multicultural society. Exaggeration in emphasizing of differences. a s well as its neglecting, would cause more or less open confrontations and thus provide the causes of dissolution of the communities. In this context main problem is how family could retained its stability if it persists under the pressure of contrary forces concerning identity. This would be resolved only if identity is conceived as an open complex and ever unfinished on lay - in endless process of building. Regionalization in this sense of the term could be perceived as a defining of the proper game rules as well as it forceful adjustment and completion.

  15. [Therapy of scoliosis from a historical perspective].

    Science.gov (United States)

    Harms, J; Rauschmann, M; Rickert, M

    2015-12-01

    Scoliosis can be considered as one of the classical orthopedic diseases of the spine. The history of orthopedics is closely connected to the development of the therapy of scoliosis. In the eighteenth and the beginning of the nineteenth centuries the therapy of scoliosis was mainly a conservative corrective orthopedic treatment with a variety of corset forms and extension bed treatment. In the middle of the nineteenth century physiotherapy (movement therapy) became established as an supplementary active treatment. The first operations for treatment of scoliosis were carried out in 1839. The real success with surgical procedures for improvement in corrective options was connected to the introduction of metal spinal implants in the early 1960s.

  16. Historical perspectives of the metabolic syndrome.

    Science.gov (United States)

    Oda, Eiji

    The metabolic syndrome (MetS) or insulin resistance syndrome is a constellation of obesity-related metabolic derangements predisposing to type 2 diabetes and cardiovascular disease. In 1998, WHO defined the first criteria of MetS. Three years later, the user-friendly National Cholesterol Education Program criteria of MetS were proposed. Different criteria were issued by the International Diabetes Federation in 2005, making abdominal obesity a necessary component. Several international societies, including The International Diabetes Federation, jointly adopted the revised National Cholesterol Education Program criteria as harmonizing criteria of MetS in 2009. WHO warned the next year that MetS has limited practical utility as a management tool. Adipose tissue inflammation has been shown to be a fundamental mechanism of metabolic derangements, associated with ectopic lipid deposit and mitochondrial dysfunction in skeletal muscle and the liver. Copyright © 2017 Elsevier Inc. All rights reserved.

  17. A HISTORICAL PERSPECTIVE OF NUCLEAR THERMAL HYDRAULICS

    Energy Technology Data Exchange (ETDEWEB)

    D’Auria, F; Rohatgi, Upendra S.

    2017-01-12

    The nuclear thermal-hydraulics discipline was developed following the needs for nuclear power plants (NPPs) and, to a more limited extent, research reactors (RR) design and safety. As in all other fields where analytical methods are involved, nuclear thermal-hydraulics took benefit of the development of computers. Thermodynamics, rather than fluid dynamics, is at the basis of the development of nuclear thermal-hydraulics together with the experiments in complex two-phase situations, namely, geometry, high thermal density, and pressure.

  18. A Historical Perspective of Technology and Planning

    OpenAIRE

    Pitkin, Bill

    2001-01-01

    Technology is our savior. We see, hear and experience this mes- sage constantly in popular culture, from advertisements that demon- strate how technological gadgets make us smarter and perhaps even more likable to forecasts by financial analysts that the information economy will continue to increase wealth for savvy investors. The hype produced by this common message implies that unless we jump on the information age bandwagon, we risk missing out on its vast benefits. Futuristic writers such...

  19. The Intelligence Revolution: A Historical Perspective

    Science.gov (United States)

    1988-10-01

    dimension. Orbis 24:771-86, Winter 1981. Gray, Colin S. Moscow is cheating. Foreign Polic No.56:141-152, 1984. Knight, Amy W. The KGB’s special... Bamford , James. The puzzle palace: a report on America’s most secret agency. Boston, MA: Houghton Mifflin, 1982. (UB 251 .U5 B35 1982) Braswell, Nancy S

  20. The uses of neutrinos: a historical perspective

    International Nuclear Information System (INIS)

    Mateos, G; Navarro, J

    2006-01-01

    When Pauli postulated the existence of a new elementary particle, the 'neutron', in the late 1930s, he was introducing an entity to fill the gaps in the physics of the day. There was no direct evidence for such a particle; only the need to account for the missing energy in beta decay processes and to explain the statistics of some nuclei. Thus, Pauli's neutron was called into existence to solve problems in the areas of radioactivity and nuclear physics; but, in time, it would prove useful in many other areas of physics. The aim of this paper is to describe the many uses the neutrino has had in physics since its appearance, uses that have determined the ontological status of this elusive particle. Interestingly, the experimental detection of neutrinos 50 years ago was a minor episode in understanding the nature of such particles. As we shall argue, other moments in the biography of the particle proved more significant in determining the uses of neutrinos and their ontology

  1. A Historical Perspective of the Paralympic Games

    Science.gov (United States)

    DePauw, Karen P.

    2012-01-01

    Athletes with disabilities are more visible in the 21st century than they used to be, including in the world of sport. Today, one hears about the Paralympic Games, can find media coverage of them, can read about athletes who compete in the Paralympics and about advancements in sport prosthetic devices in science and sport magazines, and can even…

  2. Nordic food culture – A historical perspective

    OpenAIRE

    Amilien, Virginie

    2013-01-01

    Henry Notaker is a well- known Norwegian historian, specialist of books and articles about food, culture and history. He has got awards for journalism on food history, he was responsible for TV series about food and history in the 1990’s, and he is currently teaching in food history at the universities in Bergen and Agder and at Akershus University College (courses on food culture). Henry Notaker is a member of the editorial board of the scientific journal Food & History. He has published alm...

  3. A Historical Perspective of Medical Education

    Science.gov (United States)

    Balcioglu, Huseyin; Bilge, Ugur; Unluoglu, Ilhami

    2015-01-01

    Even though there are significant developments in recent years in medical education, physicians are still needed reform and innovation in order to prepare the information society. The spots in the forefront of medical education in recent years; holistic approach in all processes, including health education, evidence-based medicine and…

  4. Gamma-ray astronomy: A historical perspective

    International Nuclear Information System (INIS)

    Lingenfelter, R.E.

    1988-01-01

    This is a brief review of the course theoretical gamma-ray astronomy has taken over the past thirty years. An examination is given of what the theoretical expectations were; to what extent they were realized; how well they anticipated new directions of research; and alternatively, how often were new directions unexpected

  5. Historical perspective on confirmatory data gathering

    International Nuclear Information System (INIS)

    Budge, D.R.

    1982-01-01

    Confirmatory earth science investigation in the nuclear power area began with the development of NRC siting standards. They arose from controversies stemming from nuclear power plant siting. The standards were intended to provide means for assessing the magnitude of a given hazard for earth scientists, and as a means to determine compliance for a regulator. They were developed for use in a quasi-legal format where technical disputes could be debated and resolved, and licensing actions brought to a conclusion satisfactory to industry, environmental groups, and professional scientists and engineers. Regulations (requirements mandated by law), regulatory guides (recommended procedures), and staff positions (statements of staff opinion) are the three basic types of NRC standards. As inherent quality of NRC's earth science standards is the recognition that an evaluation of the mutual relationships between descriptive observational data and the interpretive geologic assessment must take place; and that due to the nature of the earth science information base quantification and codification of data and conclusions are often impossible. Accordingly, siting assessment conclusions made in what is a rapidly evolving technology must frequently be reassessed and reconfirmed. In short, earth scientists and regulators dealing with the siting of nuclear facilities are working with living systems. Four major problem areas have existed in the nuclear power program. These areas deal with the development of an expanded sense of posterity, the need to more adequately scope the exact nature of a given problem, the adequacy of an existing design to envelop unforeseen concerns, and politics. These problem areas and those of the descriptive-interpretive aspects are directly transferable to waste disposal siting

  6. [Historical perspective of mass spectrometry in microbiology].

    Science.gov (United States)

    Mingorance, Jesús; Regueiro, Benito; Muñoz-Bellido, Juan Luis

    2016-06-01

    La espectrometría de masas (EM) es una técnica de análisis que permite caracterizar muestras midiendo las masas (estrictamente las razones masa-carga) de las moléculas componentes. Cuenta con más de un siglo de historia y evolución tecnológica y a lo largo de los años ha ampliado su alcance desde los isótopos a moléculas pequeñas, moléculas orgánicas más complejas y, en las últimas décadas, macromoléculas (ácidos nucleicos y proteínas). La EM MALDI-TOF (matrix-assisted laser desorption ionization time-of-flight) es una variante que permite el análisis de mezclas complejas de proteínas y que se ha aplicado recientemente a la identificación de microorganismos en cultivo, convirtiéndose en una herramienta rápida y eficaz para el diagnóstico microbiológico que ha conseguido entrar en poco tiempo en la rutina de muchos servicios de microbiología clínica. El gran impacto que ha tenido está impulsando el desarrollo de nuevas aplicaciones en el campo de la microbiología clínica. Copyright © 2016 Elsevier España, S.L.U. All rights reserved.

  7. Community Colleges in America: A Historical Perspective

    Science.gov (United States)

    Drury, Richard L.

    2003-01-01

    Drury traces the development of community colleges in America from their earliest days through modern times, describing the social, political, religious, and economic factors that influenced their development.

  8. Heat and smoke - a historical perspective

    Energy Technology Data Exchange (ETDEWEB)

    Hester, C. [SIMTARS, Redbank, Qld. (Australia)

    2002-01-01

    From 1891 until 1947 coal was used to fire the boiler at the water supply pumping station at Mount Crosby, near Ipswich in south-east Queensland. Ash and waste coal was tipped over the nearest bank which lay between the boiler house and the Brisbane River. By 1947 thousands of tonnes of hot waste had been ejected, covered with a meagre amount of soil, and forgotten. In 1953 the river began to rise in an extensive flow that its 4000 square mile catchment periodically caused, and water sped over the earth fill. A portion of the bank collapsed into the water and when it did, there was a huge and continuing efflux of steam from the ash and coal waste, which had remained heated for as long as 60 years. The possibility of a water gas reaction having caused this 'explosion' cannot be ruled out. This incident gives an indication of the lasting problems associated with discarded coal waste; and the fact that these problem rarely go away of their own accord. Readers interested in details of heat stress or requiring information on compliance monitoring related to the EPA Environmental Protection (Air) Policy are referred to the Queensland Government's Environment and Chemistry Centre. 3 photos.

  9. Gender and social reproduction: historical perspectives.

    Science.gov (United States)

    Laslett, B; Brenner, J

    1989-01-01

    It is argued that gender relations and social reproduction were both shaped by macrohistorical processes and shaped the processes. Social reproduction is defined within feminist theory as more than production in the Marxist sense. Societal reproduction is a combination of the organization of production, the organization of social reproduction, the perpetuation of gender, and the continuation of class relations. Social reproduction includes the care and socialization of children and care of the elderly or infirm. Social reproduction includes the organization of sexuality, biological reproduction, and how food, clothing, and shelter are made available. Most social reproduction occurs within the family unit. It is pointed out that variations in the distribution of the work of social reproduction are affected by the family, market, community, and state. The ways in which women construct their own worlds of activity is a central concern. The feminist concept of social reproduction differs from modernization theory, which is concerned with the institutional location of the tasks of social reproduction and the structural effects on the family and gender relations. This literature review focuses only on the history of family strategies and separate gender-related activities. The authors describe the changes in family organization that define men as income producers and women as caretakers, who base child rearing on love and feminine virtue rather than patriarchal authority and religious doctrine. The discussion focuses on the differences in marital relationships, motherhood, and sexuality between upper and middle class and working class women in the 19th century. Among working class women, a good wife was an efficient manager, a skilled domestic worker, and an income earner. The turn of the century was a period of social change marked by smaller average family size, the decline of household production, the rise in real wages, and increased consumption. It is argued that new developments in gender relations are due to sex as well as economics and the institutionalization of these changes results in constraints and opportunities for women.

  10. Historical perspectives on pollution in the city

    International Nuclear Information System (INIS)

    Jacobson, C.D.

    2001-01-01

    This essay reviews two books - 'The Sanitary City: Urban Infrastructure in America from Colonial Times to the Present' by Martin V Melosi, and 'Smokestacks and Progressives: Environmental, Engineers, and Air Quality in America 1881-1951' by David Stradling both published by Johns Hopkins University Press. The first book focuses on the development of water supply, wastewater, and solid waste disposal systems in urban areas in America, and examines the relationship between disease and sanitation, the identification of bacteria as the cause of illnesses, and the rise of environmental and ecological concerns. The second book concentrates on the attempts of reformers to persuade/compel facilities to curb their emissions, and discusses the efforts of municipal governments to regulate the grades of coal, smoke and other pollutants

  11. A Historical Perspective on Light Infantry

    Science.gov (United States)

    1987-01-01

    which were scarce) expecting the enemy to use them in building fires. In another case, the CCF draped a large wire entanglement across a village...Jungle Frontier: 92 Special Air Service Regiment in the Borneo Campaign, 1963-1966 (London: Arms and Armour Press, 1985), 65, 57. Lieutenant Colonel P. E...1963-1966. London: Arms and Armour Press, 1985. Foxley-Norris, C. N., Air Vice Marshal, "Air Aspects of Operations Against ’Confrontation.’ " In

  12. An historical review and perspective of AINSE

    International Nuclear Information System (INIS)

    Ophel, T.R.

    1998-01-01

    Full text: ANSTO was formed in 1958 as a cooperative venture of modest scope, involving the newly established AAEC (created by the Atomic Energy Act of 1953 with facilities at Lucas Heights being formally opened in 1955) and the eight universities that existed at the time. Research emphasis was very much nuclear, with the two reactors MOATA and HIFAR and possible future nuclear energy developments defining it. Two accelerators, added in the early sixties - the 3 MV Van de Graaff and the 1.3 MV electron machine, were to sustain those original activities of the AAEC. It would probably be true to say that AINSE in those early days placed much importance on the general support of nuclear science throughout Australia, whereas now of course the facilitation of the use of ANSTO facilities has become the main function. Thereafter, both AINSE and the AAEC have undergone dramatic change. The number of universities expanded to 19 in the late sixties, along with more support and encouragement for research at both the new institutions and the original group of eight. University use of Lucas Heights facilities, through the agency of AINSE, expanded and began to diversify somewhat into other disciplines - a trend that has continued apace ever since. In the nineties, the Dawkins revolution led to a doubling of the number of tertiary institutions, so that once again AINSE experienced a quantum jump in size, with of course matching complexity. In parallel, AAEC broadened its activities to embrace a wide range of nuclear and energy related areas, though basic research began to taper off. Finally, the organization was given a new charter in 1985 and re-named ANSTO. A much expanded university system, the 'new' ANSTO, the rise of economic rationalism and the creation of the Australian Research Council have combined to provide a succession of challenges to AINSE. From the original small, club-like beginning with narrow interests, AINSE has emerged with more than a four-fold increase in membership, to foster research within almost all of the Faculties of those members

  13. Fifty years chlorpromazine: a historical perspective.

    Science.gov (United States)

    Ban, Thomas A

    2007-08-01

    Chlorpromazine was synthesized in December 1951 in the laboratories of Rhône-Poiulenc, and became available on prescription in France in November 1952. Its effectiveness was reflected in the transformation of disturbed wards; its commercial success stimulated the development of other psychotropic drugs. Recognition of chemical mediation at the site of the synapse, followed by the introduction of the spectrophotofluorimeter first, and receptor assays subsequently, led to the demonstration that chlorpromazine blocks dopamine receptors. Treatment with chlorpromazine focused attention on the heterogeneity of schizophrenia in terms of responsiveness to treatment. By the mid-1980s there was sufficient evidence to believe that resolving this heterogeneity is a prerequisite for developing more effective treatments. Chlorpromazine was instrumental in the development of neuropsychopharmacology, a new discipline dedicated to the study of mental pathology with the employment of centrally acting drugs.

  14. Historical perspective on the use of garlic.

    Science.gov (United States)

    Rivlin, R S

    2001-03-01

    The objective of this review is to examine briefly the medical uses of garlic throughout the ages and the role that it was considered to play in prevention and treatment of disease. Interest in the potential benefits of garlic has origins in antiquity and is one of the earliest documented examples of plants employed for treatment of disease and maintenance of health. Garlic was in use at the beginning of recorded history and was found in Egyptian pyramids and ancient Greek temples. There are Biblical references to garlic. Ancient medical texts from Egypt, Greece, Rome, China and India each prescribed medical applications for garlic. In many cultures, garlic was administered to provide strength and increase work capacity for laborers. Hippocrates, the revered physician, prescribed garlic for a variety of conditions. Garlic was given to the original Olympic athletes in Greece, as perhaps one of the earliest "performance enhancing" agents. It is of interest that cultures that developed without contact with one another came to similar conclusions about the efficacy of garlic. Modern science is tending to confirm many of the beliefs of ancient cultures regarding garlic, defining mechanisms of action and exploring garlic's potential for disease prevention and treatment.

  15. Teleultrasound: Historical Perspective and Clinical Application

    Directory of Open Access Journals (Sweden)

    Adilson Cunha Ferreira

    2015-01-01

    Full Text Available The health care of patients in rural or isolated areas is challenged by the scarcity of local resources, limited patient access to doctors and hospitals, and the lack of specialized professionals. This has led to a new concept in telemedicine: teleultrasonography (or teleultrasound, which permits ultrasonographic diagnoses to be performed remotely. Telemedicine and teleultrasonography are effective in providing diagnostic imaging services to these populations and reduce health care costs by decreasing the number and duration of hospitalizations and reducing unnecessary surgical procedures. This is a narrative review to present the potential clinical applications of teleultrasonography in clinical practice. The results indicate that although barriers persist for implementing teleultrasonography in a more universal and routine way, advances in telecommunications, Internet bandwidth, and the high resolution currently available for portable ultrasonography suggest teleultrasonography applications will continue to expand. Teleultrasound appears to be a valuable addition to remote medical care for isolated populations with limited access to tertiary healthcare facilities and also a useful tool for education and training.

  16. "Globalised sports in a historical perspective"

    OpenAIRE

    Christer Ericsson; Bjorn Horgby

    2010-01-01

    The great interest in Asia for European, male football is an expression of globalised sports. Here globalisation and processes of globalisation stands for the economical, social and cultural processes, which link and affect globally. Global capitalism created a world hegemony. As a consequence the hegemonic power of the western world (including Japan) until now will be the norm of interpretation. A precondition for the development of globalised sports as an industry of entertainment is the de...

  17. Physics and medicine: a historical perspective.

    Science.gov (United States)

    Keevil, Stephen F

    2012-04-21

    Nowadays, the term medical physics usually refers to the work of physicists employed in hospitals, who are concerned mainly with medical applications of radiation, diagnostic imaging, and clinical measurement. This involvement in clinical work began barely 100 years ago, but the relation between physics and medicine has a much longer history. In this report, I have traced this history from the earliest recorded period, when physical agents such as heat and light began to be used to diagnose and treat disease. Later, great polymaths such as Leonardo da Vinci and Alhazen used physical principles to begin the quest to understand the function of the body. After the scientific revolution in the 17th century, early medical physicists developed a purely mechanistic approach to physiology, whereas others applied ideas derived from physics in an effort to comprehend the nature of life itself. These early investigations led directly to the development of specialties such as electrophysiology, biomechanics, and ophthalmology. Physics-based medical technology developed rapidly during the 19th century, but it was the revolutionary discoveries about radiation and radioactivity at the end of the century that ushered in a new era of radiation-based medical diagnosis and treatment, thereby giving rise to the modern medical physics profession. Subsequent developments in imaging in particular have revolutionised the practice of medicine. We now stand on the brink of a new revolution in post-genomic personalised medicine, with physics-based techniques again at the forefront. As before, these techniques are often the unpredictable fruits of earlier investment in basic physics research. Copyright © 2012 Elsevier Ltd. All rights reserved.

  18. Constructing Worlds of Education: A Historical Perspective

    Science.gov (United States)

    Droux, Joëlle; Hofstetter, Rita

    2015-01-01

    Over the past two decades, historians have dedicated a growing amount of research to the history of globalization. This introduction shows how the articles in this issue contribute to this dynamic, aiming to illustrate its heuristic potential in historicizing educational phenomena. The field of education is presented as a relevant platform for an…

  19. The Intelligence Revolution: A Historical Perspective

    Science.gov (United States)

    1988-10-01

    1979), is a useful survey. 7. Cf. Zara Steiner , The Foreign Office and Foreign Policy, 1898-1914 (Cambridge, 1969); and Lamar F. Cecil, The German...falsifying two identity of these people. You may recall that Rudolf Abel was arrested in New York in the 1950s. He was later exchanged, I believe, for

  20. ACCOUNTING PARADIGMS WHICH FAVOR HISTORICAL COST

    Directory of Open Access Journals (Sweden)

    Valentin Gabriel CRISTEA

    2014-05-01

    Full Text Available Henning Kirkegaard shows that the evolution of accounting is to shift from one paradigm to another . Business continuity perspective should guide the company into the future , without confine it exclusively in the past. Accounting in its classical form , however, can not be dissociated from the historical cost evaluation .