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Sample records for hong kong h5n1

  1. A review on human influenza A H5N1 infections in Hong Kong

    Institute of Scientific and Technical Information of China (English)

    CHAN Paul K S

    2009-01-01

    Avian influenza A H5N1 remains the most threatening virus that may cause another devastating pan-demic in the foreseeable future, In 1997, Hong Kong was the first place to detect human infections due to this virus originated from birds. The experience and lessons learnt provide important information for controlling further outbreaks caused by avian influenza viruses.

  2. A review on human influenza A H5N1 infections in Hong Kong

    Institute of Scientific and Technical Information of China (English)

    CHAN; Paul; K; S

    2009-01-01

    Avian influenza A H5N1 remains the most threatening virus that may cause another devastating pandemic in the foreseeable future. In 1997, Hong Kong was the first place to detect human infections due to this virus originated from birds. The experience and lessons learnt provide important information for controlling further outbreaks caused by avian influenza viruses.

  3. Investigation of outbreaks of highly pathogenic H5N1 avian influenza in waterfowl and wild birds in Hong Kong in late 2002.

    Science.gov (United States)

    Ellis, Trevor M; Bousfield, R Barry; Bissett, Lucy A; Dyrting, Kitman C; Luk, Geraldine S M; Tsim, S T; Sturm-Ramirez, Katharine; Webster, Robert G; Guan, Yi; Malik Peiris, J S

    2004-10-01

    Outbreaks of highly pathogenic H5N1 avian influenza have occurred in Hong Kong in chickens and other gallinaceous poultry in 1997, 2001, twice in 2002 and 2003. High mortality rates were seen in gallinaceous birds but not in domestic or wild waterfowl or other wild birds until late 2002 when highly pathogenic H5N1 avian influenza occurred in waterfowl (geese, ducks and swans), captive Greater Flamingo (Phoenicopterus ruber) and other wild birds (Little Egret Egretta garzetta) at two waterfowl parks and from two dead wild Grey Heron (Ardea cinerea) and a Black-headed Gull (Larus ridibundus) in Hong Kong. H5N1 avian influenza virus was also isolated from a dead feral pigeon (Columba livia) and a dead tree sparrow (Passer montanus) during the second outbreak. The first waterfowl outbreak was controlled by immediate strict quarantine and depopulation 1 week before the second outbreak commenced. Control measures implemented for the second outbreak included strict isolation, culling, increased sanitation and vaccination. Outbreaks in gallinaceous birds occurred in some live poultry markets concurrently with the second waterfowl outbreak, and infection on a chicken farm was detected 1 week after the second waterfowl park outbreak was detected, on the same day the second grey heron case was detected. Subsequent virus surveillance showed the outbreaks had been contained.

  4. H5N1 avian influenza virus: human cases reported in southern China.

    NARCIS (Netherlands)

    Crofts, J.; Paget, J.; Karcher, F.

    2003-01-01

    Two cases of confirmed influenza due to the avian influenza A H5N1 virus were reported last week in Hong Kong (1). The cases occurred in a Hong Kong family who had recently visited Fujian province in southern China. The daughter, aged 8 years, died following a respiratory illness. The cause of her d

  5. Hong Kong Fashions

    Institute of Scientific and Technical Information of China (English)

    1997-01-01

    Fashion in Hong Kong has quickly developed. In the 1980s the Hong Kong Developing Bureau started holding the Hong Kong International Fashion Festival. This promoted development in the manufacturing and processing of the garment trade, making Hong Kong the garment center of Southeast Asia.

  6. TOUR OF HONG KONG

    Institute of Scientific and Technical Information of China (English)

    1997-01-01

    SITUATED on the shore of the South China Sea and east of the mouth of the Pearl River, Hong Kong consists of three parts: Hong Kong Island, Kowloon and the New Territories. With an area of 1,092 sq kms and a population of 6.31 million, Hong Kong is well-positioned geographically. Facing Southeast Asia and at the communications hub of the shippinglines in the Pacific and Indian oceans,plus deepwater ports, Hong Kong’s economy skyrocketed in the years following World War Ⅱ. Trade began booming after Hong Kong completed the transition from entrepot trade to

  7. Human avian influenza A (H5N1) virus infection in China

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    Highly pathogenic influenza A (H5N1) virus causes a widespread poultry deaths worldwide. The first human H5N1 infected case was reported in Hong Kong Special Administrative Region of China in 1997. Since then, the virus re-emerged in 2003 and continues to infect people worldwide. Currently, over 400 human infections have been reported in more than 15 countries and mortality rate is greater than 60%. H5N1 viruses still pose a potential pandemic threat in the future because of the continuing global spread and evolution. Here, we summarize the epidemiological, clinical and virological characteristics of human H5N1 infection in China monitored and identified by our national surveillance systems.

  8. Proinflammatory cytokine responses induced by influenza A (H5N1 viruses in primary human alveolar and bronchial epithelial cells

    Directory of Open Access Journals (Sweden)

    Poon LLM

    2005-11-01

    Full Text Available Abstract Background Fatal human respiratory disease associated with influenza A subtype H5N1 has been documented in Hong Kong, and more recently in Vietnam, Thailand and Cambodia. We previously demonstrated that patients with H5N1 disease had unusually high serum levels of IP-10 (interferon-gamma-inducible protein-10. Furthermore, when compared with human influenza virus subtype H1N1, the H5N1 viruses in 1997 (A/Hong Kong/483/97 (H5N1/97 were more potent inducers of pro-inflammatory cytokines (e.g. tumor necrosis factor-a and chemokines (e.g. IP-10 from primary human macrophages in vitro, which suggests that cytokines dysregulation may play a role in pathogenesis of H5N1 disease. Since respiratory epithelial cells are the primary target cell for replication of influenza viruses, it is pertinent to investigate the cytokine induction profile of H5N1 viruses in these cells. Methods We used quantitative RT-PCR and ELISA to compare the profile of cytokine and chemokine gene expression induced by H5N1 viruses A/HK/483/97 (H5N1/97, A/Vietnam/1194/04 and A/Vietnam/3046/04 (both H5N1/04 with that of human H1N1 virus in human primary alveolar and bronchial epithelial cells in vitro. Results We demonstrated that in comparison to human H1N1 viruses, H5N1/97 and H5N1/04 viruses were more potent inducers of IP-10, interferon beta, RANTES (regulated on activation, normal T cell expressed and secreted and interleukin 6 (IL-6 in primary human alveolar and bronchial epithelial cells in vitro. Recent H5N1 viruses from Vietnam (H5N1/04 appeared to be even more potent at inducing IP-10 than H5N1/97 virus. Conclusion The H5N1/97 and H5N1/04 subtype influenza A viruses are more potent inducers of proinflammatory cytokines and chemokines in primary human respiratory epithelial cells than subtype H1N1 virus. We suggest that this hyper-induction of cytokines may be relevant to the pathogenesis of human H5N1 disease.

  9. Hong Kong Geological Survey

    Institute of Scientific and Technical Information of China (English)

    R J Sewell

    2007-01-01

    @@ History and objectives The Hong Kong Geological Survey(HKGS) was created on 5 May,1982,wimin the then Engineering Development Department of the Hong Kong Govemment.The initial objective was to carry out a new geological survey of the Territory at 1∶20,000 scale.This followed recognition of an urgent need to produce high quality geological maps at a large scale with sufficient detail to facilitate physical planning and land use management of Hong Kong.

  10. Hong Kong - Aalborg

    DEFF Research Database (Denmark)

    Nielsen, Peter V.

    2006-01-01

    Artiklen beskriver nogle forløb i SARS epidemien fra efteråret 2002 til sommeren 2003 i Hong Kong. Epidemien blev starten på samarbejdet mellem universitet i Hong Kong og Aalborg Universiter, hvor man i en årrække har forsket i udviklingen af ventilationssystemer der kan forhindre sygdomssprednin...... på hospitaler og sengestuer....

  11. Generation and Characterization of Monoclonal Antibodies Specific to Avian Influenza H5N1 Hemagglutinin Protein.

    Science.gov (United States)

    Malik, Ankita; Mallajosyula, V Vamsee Aditya; Mishra, Nripendra Nath; Varadarajan, Raghavan; Gupta, Satish Kumar

    2015-12-01

    Highly pathogenic avian influenza (HPAI) H5N1 virus has in the past breached the species barrier from infected domestic poultry to humans in close contact. Although human-to-human transmission has previously not been reported, HPAI H5N1 virus has pandemic potential owing to gain of function mutation(s) and/or genetic reassortment with human influenza A viruses. Monoclonal antibodies (MAbs) have been used for diagnosis as well as specific therapeutic candidates in several disease conditions including viral infections in humans. In this study, we describe the preliminary characterization of four murine MAbs developed against recombinant hemagglutinin (rHA) protein of avian H5N1 A/turkey/Turkey/1/2005 virus that are either highly specific or broadly reactive against HA from other H5N1 subtype viruses, such as A/Hong Kong/213/03, A/Common magpie/Hong Kong/2256/2006, and A/Barheaded goose/Quinghai/14/2008. The antibody binding is specific to H5N1 HAs, as none of the antibodies bound H1N1, H2N2, H3N2, or B/Brisbane/60/2008 HAs. Out of the four MAbs, one of them (MA-7) also reacted weakly with the rHA protein of H7N9 A/Anhui/1/2013. All four MAbs bound H5 HA (A/turkey/Turkey/1/2005) with high affinity with an equilibrium dissociation constant (KD) ranging between 0.05 and 10.30 nM. One of the MAbs (MA-1) also showed hemagglutination inhibition activity (HI titer; 31.25 μg/mL) against the homologous A/turkey/Turkey/1/2005 H5N1 virus. These antibodies may be useful in developing diagnostic tools for detection of influenza H5N1 virus infection.

  12. A Travel To Hong Kong

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    This summer holiday,I had travelled to Hong Kong with many other students.We went to Hong Kong by plane.Hong Kong is very small,but there are many people living there. In Hong Kong,all of the buildings are very tall.There are lots of shops there and

  13. Hong Kong: country profile.

    Science.gov (United States)

    Fozzard, A

    1988-09-01

    In the 1840s, the small fishing community that is now Hong Kong became a British colony and an important naval base for the Opium Wars. Now it is a leading capitalist center operating on mainland communist China. Hong Kong is scheduled to go back to China in 1997. In the agreement signed between the British government and China, Hong Kong's present lifestyle is guaranteed for at least 50 years. Textbook colonialism rules here. Foreigners hold the key jobs and earn much more than do the indigenous people. They even receive subsidized housing in this very high rent colony. As for the Hong Kong Chinese, overcrowding into 2 room apartments is the norm even though the government tries to provide more housing units. The large skyscrapers in the New Territories breed their unique social and mental health problems, such as poverty, drug abuse and frustration. Essentially all food is imported from communist China, yet agriculture in Hong Kong does exist--pig farms, duck lakes, and fields of the popular vegetable choi sum. Major industry comprise textiles and sweat shops which pay their workers (mostly illegal immigrants and children with no legal protection) wages that are 1/4 of those paid in Great Britain. Financial services, trade, and tourism may soon dominate Hong Kong's economy. Almost 4 million tourists visit Hong Kong yearly, often looking for bargains. Despite Hong Kong's active Western-like business climate, Chinese culture still abounds. Traditional incense burns in Buddhist temples. Snake soup is served in restaurants. Plus traditional medicine practiced alongside Western medicine contributes to Hong Kong having 1 of the lowest infant mortality rates in the world (9/1000) and to its high life expectancy of 76 years.

  14. Implementing Hong Kong English into Hong Kong language curriculum

    OpenAIRE

    Kwan, Joanna Long-Lam

    2010-01-01

    Recognising the autonomy of Hong Kong English, which has become increasingly controversial in linguistic research, requires Hong Kong people to develop a sense of local identity within the English Language and to recognise its linguistic distinctiveness. Since local English Language teachers are believed to play a crucial role in the process, the study in this thesis examines these teachers’ perceptions towards the issues of Hong Kong English and seeks potentials for implementing Hong Kong En...

  15. Hong Kong's Foundry Industry Survey

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    @@ Hong Kong, as one of the global economy centers, its manufacturing industry is well-known to the world. Foundry industry is named as "The Father of Manufacturing Industry",and in Hong Kong there currently are 1 500 enterprises, staffed with 500 000 employees. The following are some special features of the Hong Kong foundry industry.

  16. Avian Influenza A (H5N1)

    Centers for Disease Control (CDC) Podcasts

    2009-05-27

    In this podcast, CDC's Dr. Tim Uyeki discusses H5N1, a subtype of influenza A virus. This highly pathogenic H5N1 virus doesn't usually infect people, although some rare infections with H5N1 viruses have occurred in humans. We need to use a comprehensive strategy to prevent the spread of H5N1 virus among birds, including having human health and animal health work closely together.  Created: 5/27/2009 by Emerging Infectious Diseases.   Date Released: 5/27/2009.

  17. The variable codons of H5N1 avian influenza A virus haemagglutinin genes

    Institute of Scientific and Technical Information of China (English)

    Mark; J.GIBBS; Robert; W.MURPHY

    2008-01-01

    We investigated the selection pressures on the haemagglutinin genes of H5N1 avian influenza viruses using fixed effects likelihood models. We found evidence of positive selection in the sequences from isolates from 1997 to 2007, except viruses from 2000. The haemagglutinin sequences of viruses from southeast Asia, Hong Kong and mainland China were the most polymorphic and had similar nonsyn-onymous profiles. Some sites were positively selected in viruses from most regions and a few of these sites displayed different amino acid patterns. Selection appeared to produce different outcomes in vi-ruses from Europe, Africa and Russia and from different host types. One position was found to be positively selected for human isolates only. Although the functions of some positively selected posi-tions are unknown, our analysis provided evidence of different temporal, spatial and host adaptations for H5N1 avian influenza viruses.

  18. Human mesenchymal stromal cells reduce influenza A H5N1-associated acute lung injury in vitro and in vivo.

    Science.gov (United States)

    Chan, Michael C W; Kuok, Denise I T; Leung, Connie Y H; Hui, Kenrie P Y; Valkenburg, Sophie A; Lau, Eric H Y; Nicholls, John M; Fang, Xiaohui; Guan, Yi; Lee, Jae W; Chan, Renee W Y; Webster, Robert G; Matthay, Michael A; Peiris, J S Malik

    2016-03-29

    Influenza can cause acute lung injury. Because immune responses often play a role, antivirals may not ensure a successful outcome. To identify pathogenic mechanisms and potential adjunctive therapeutic options, we compared the extent to which avian influenza A/H5N1 virus and seasonal influenza A/H1N1 virus impair alveolar fluid clearance and protein permeability in an in vitro model of acute lung injury, defined the role of virus-induced soluble mediators in these injury effects, and demonstrated that the effects are prevented or reduced by bone marrow-derived multipotent mesenchymal stromal cells. We verified the in vivo relevance of these findings in mice experimentally infected with influenza A/H5N1. We found that, in vitro, the alveolar epithelium's protein permeability and fluid clearance were dysregulated by soluble immune mediators released upon infection with avian (A/Hong Kong/483/97, H5N1) but not seasonal (A/Hong Kong/54/98, H1N1) influenza virus. The reduced alveolar fluid transport associated with down-regulation of sodium and chloride transporters was prevented or reduced by coculture with mesenchymal stromal cells. In vivo, treatment of aged H5N1-infected mice with mesenchymal stromal cells increased their likelihood of survival. We conclude that mesenchymal stromal cells significantly reduce the impairment of alveolar fluid clearance induced by A/H5N1 infection in vitro and prevent or reduce A/H5N1-associated acute lung injury in vivo. This potential adjunctive therapy for severe influenza-induced lung disease warrants rapid clinical investigation.

  19. Four Outstanding Women Visit Hong Kong

    Institute of Scientific and Technical Information of China (English)

    1996-01-01

    ON March 2, four of the "Ten Outstanding Chinese Women" of 1995, joined the delegation of the All-China Women’s Federation (ACWF) on its visit to Hong Kong, and delivered speeches to more than 500 Hong Kong women. They visited Hong Kong with the ACWF delegation at the invitation of women’s organizations in Hong Kong.

  20. Acid Stability of the Hemagglutinin Protein Regulates H5N1 Influenza Virus Pathogenicity

    Energy Technology Data Exchange (ETDEWEB)

    DuBois, Rebecca M.; Zaraket, Hassan; Reddivari, Muralidhar; Heath, Richard J.; White, Stephen W.; Russell, Charles J. (Tennessee-HSC); (SJCH)

    2012-12-10

    Highly pathogenic avian influenza viruses of the H5N1 subtype continue to threaten agriculture and human health. Here, we use biochemistry and x-ray crystallography to reveal how amino-acid variations in the hemagglutinin (HA) protein contribute to the pathogenicity of H5N1 influenza virus in chickens. HA proteins from highly pathogenic (HP) A/chicken/Hong Kong/YU562/2001 and moderately pathogenic (MP) A/goose/Hong Kong/437-10/1999 isolates of H5N1 were found to be expressed and cleaved in similar amounts, and both proteins had similar receptor-binding properties. However, amino-acid variations at positions 104 and 115 in the vestigial esterase sub-domain of the HA1 receptor-binding domain (RBD) were found to modulate the pH of HA activation such that the HP and MP HA proteins are activated for membrane fusion at pH 5.7 and 5.3, respectively. In general, an increase in H5N1 pathogenicity in chickens was found to correlate with an increase in the pH of HA activation for mutant and chimeric HA proteins in the observed range of pH 5.2 to 6.0. We determined a crystal structure of the MP HA protein at 2.50 {angstrom} resolution and two structures of HP HA at 2.95 and 3.10 {angstrom} resolution. Residues 104 and 115 that modulate the acid stability of the HA protein are situated at the N- and C-termini of the 110-helix in the vestigial esterase sub-domain, which interacts with the B loop of the HA2 stalk domain. Interactions between the 110-helix and the stalk domain appear to be important in regulating HA protein acid stability, which in turn modulates influenza virus replication and pathogenesis. Overall, an optimal activation pH of the HA protein is found to be necessary for high pathogenicity by H5N1 influenza virus in avian species.

  1. Live, attenuated influenza A H5N1 candidate vaccines provide broad cross-protection in mice and ferrets.

    Directory of Open Access Journals (Sweden)

    Amorsolo L Suguitan

    2006-09-01

    Full Text Available BACKGROUND: Recent outbreaks of highly pathogenic influenza A H5N1 viruses in humans and avian species that began in Asia and have spread to other continents underscore an urgent need to develop vaccines that would protect the human population in the event of a pandemic. METHODS AND FINDINGS: Live, attenuated candidate vaccines possessing genes encoding a modified H5 hemagglutinin (HA and a wild-type (wt N1 neuraminidase from influenza A H5N1 viruses isolated in Hong Kong and Vietnam in 1997, 2003, and 2004, and remaining gene segments derived from the cold-adapted (ca influenza A vaccine donor strain, influenza A/Ann Arbor/6/60 ca (H2N2, were generated by reverse genetics. The H5N1 ca vaccine viruses required trypsin for efficient growth in vitro, as predicted by the modification engineered in the gene encoding the HA, and possessed the temperature-sensitive and attenuation phenotypes specified by the internal protein genes of the ca vaccine donor strain. More importantly, the candidate vaccines were immunogenic in mice. Four weeks after receiving a single dose of 10(6 50% tissue culture infectious doses of intranasally administered vaccines, mice were fully protected from lethality following challenge with homologous and antigenically distinct heterologous wt H5N1 viruses from different genetic sublineages (clades 1, 2, and 3 that were isolated in Asia between 1997 and 2005. Four weeks after receiving two doses of the vaccines, mice and ferrets were fully protected against pulmonary replication of homologous and heterologous wt H5N1 viruses. CONCLUSIONS: The promising findings in these preclinical studies of safety, immunogenicity, and efficacy of the H5N1 ca vaccines against antigenically diverse H5N1 vaccines provide support for their careful evaluation in Phase 1 clinical trials in humans.

  2. Hong Kong English: phonological features

    Directory of Open Access Journals (Sweden)

    Irina-Ana Drobot

    2008-01-01

    Full Text Available The aim of the paper is to present phonological features of Hong Kong English, which is a variety of New English. I examine features of the sound system (vowel and consonantal systems, characteristics of stress, rhythm, intonation, and phonological processes of the English spoken by Hongkongers. The way in which the accent and characteristics of the Hong Kong variety of English differs from standard, RP English is pointed out. Influences of Chinese and Cantonese on the phonological features of Hong Kong English are noticeable

  3. The European Union faces up to the threat of a pandemic: meeting at the DGV on the influenza A (H5N1) of the ad hoc group on communicable diseases Luxembourg 14 January 1998.

    Science.gov (United States)

    Desenclos, J-C.; Manigat, R

    1998-03-01

    The transmission of an avian influenza H5N1 virus to a child in Hong Kong in May 1997 followed by the occurrence of 17 other human cases with a high case fatality rate (6/18, 33%) suggested that an influenza pandemic could be imminent and led many Europea

  4. Malignant mesothelioma in Hong Kong.

    Science.gov (United States)

    Chang, Kwok C; Leung, Chi C; Tam, Cheuk M; Yu, Wai C; Hui, David S; Lam, Wah K

    2006-01-01

    Malignant mesothelioma (mesothelioma) is rare. We conducted the first systematic study of the epidemiology of mesothelioma in Hong Kong from 1988 to May 2002 by reviewing medical records. Mesothelioma patients were identified from the database of 12 out of 20 hospitals that would have admitted mesothelioma patients territory-wide. These 12 hospitals served 73% of the total hospital bed-years of the 20 hospitals. We identified 67 mesothelioma patients. The estimated annual incidence was one per million, which was similar to the background incidence of one to two per million among Caucasians. Occupational history was available in 43 subjects. Three quarters of mesothelioma patients with available occupational history had occupational asbestos exposure. Restricting analysis to 48 patients with accessible medical records and using 67 occupational asbestosis patients for comparison, the epidemiology of mesothelioma in Hong Kong shares similarities with the literature: mean age of 63 years upon diagnosis, mean latency of 46 years, median survival of 9.5 months, male predominance, selective presentation among women, high prevalence among workers in ships and dockyards, predominantly epithelioid type, lower prevalence of asbestos bodies, and negative association with pleural plaques. Asbestos consumption in Hong Kong rose in the 1970s and peaked in early 1980s and late 1990s. Hong Kong may encounter an epidemic of mesothelioma in the 2010s if effective occupational asbestos control measures are not in place.

  5. Stormwater Management in Hong Kong

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    This paper presents the practice of stormwater management in Hong Kong. It gives an overview of the current situation as regards to the organization, policies and strategies, the technologies adopted, and the economics and financing aspects relevant to implementation of the management practices. The influencing factors and trends in future development of stormwater management are also discussed.

  6. Roaming yuppies: Hong Kong migration to Australia.

    Science.gov (United States)

    Wong, S

    1994-01-01

    "Hong Kong has been the top source for Asian migration to Australia in recent years. The majority of the Hong Kong migrants are young, educated professionals. Using survey data conducted in Hong Kong on emigration tendencies, this article analyzes why they are leaving Hong Kong, what attracts them to Australia, and what impact this influx has on Australian society. It is speculated that this movement may create an enduring change in the identity of emigrant Hong Kongers and have a wider significance in the contradictory currents of geopolitics and geoeconomics which are simultaneously encouraging and resisting migration."

  7. Avian influenza and pandemic influenza preparedness in Hong Kong.

    Science.gov (United States)

    Lam, Ping Yan

    2008-06-01

    Avian influenza A H5N1 continues to be a major threat to global public health as it is a likely candidate for the next influenza pandemic. To protect public health and avert potential disruption to the economy, the Hong Kong Special Administrative Region Government has committed substantial effort in preparedness for avian and pandemic influenza. Public health infrastructures for emerging infectious diseases have been developed to enhance command, control and coordination of emergency response. Strategies against avian and pandemic influenza are formulated to reduce opportunities for human infection, detect pandemic influenza timely, and enhance emergency preparedness and response capacity. Key components of the pandemic response include strengthening disease surveillance systems, updating legislation on infectious disease prevention and control, enhancing traveller health measures, building surge capacity, maintaining adequate pharmaceutical stockpiles, and ensuring business continuity during crisis. Challenges from avian and pandemic influenza are not to be underestimated. Implementing quarantine and social distancing measures to contain or mitigate the spread of pandemic influenza is problematic in a highly urbanised city like Hong Kong as they involved complex operational and ethical issues. Sustaining effective risk communication campaigns during interpandemic times is another challenge. Being a member of the global village, Hong Kong is committed to contributing its share of efforts and collaborating with health authorities internationally in combating our common public health enemy.

  8. Quality of Life in Hong Kong: The CUHK Hong Kong Quality of Life Index

    Science.gov (United States)

    Chan, Ying Keung; Kwan, Cheuk Chiu Andy; Shek, Tan Lei Daniel

    2005-01-01

    The CUHK Hong Kong Quality of Life Index, which aims to assess and monitor the quality of life in Hong Kong, is a composite index incorporating both objective and subjective measures. This index, developed by the Faculty of Social Science of The Chinese University of Hong Kong, employs data collected in representative sample surveys and official…

  9. Hong Kong: Ten Years After the Handover

    Science.gov (United States)

    2007-06-29

    stockholder of the newspaper, Robert Kuok Hock Nien; and in 2004, the hosts of the radio shows “Smoke Signals” (Fung Yin), “Teacup in a Tempest” (Fung Bor...35 For a description of the pre-Handover Hong Kong economic network, see Hong Hong Advantage, by Michael Enright , Edith Scott, and David Dodwell...Hong Kong & the Pearl River Delta: The Economic Interaction, by Michael J. Enright , Chang Ka Mun, Edith Scott, and Zhu Wen Hui, sponsored by the 2022

  10. Neurovirulence of H5N1 infection in ferrets is mediated by multifocal replication in distinct permissive neuronal cell regions.

    Directory of Open Access Journals (Sweden)

    Jennifer R Plourde

    Full Text Available Highly pathogenic avian influenza A (HPAI, subtype H5N1, remains an emergent threat to the human population. While respiratory disease is a hallmark of influenza infection, H5N1 has a high incidence of neurological sequelae in many animal species and sporadically in humans. We elucidate the temporal/spatial infection of H5N1 in the brain of ferrets following a low dose, intranasal infection of two HPAI strains of varying neurovirulence and lethality. A/Vietnam/1203/2004 (VN1203 induced mortality in 100% of infected ferrets while A/Hong Kong/483/1997 (HK483 induced lethality in only 20% of ferrets, with death occurring significantly later following infection. Neurological signs were prominent in VN1203 infection, but not HK483, with seizures observed three days post challenge and torticollis or paresis at later time points. VN1203 and HK483 replication kinetics were similar in primary differentiated ferret nasal turbinate cells, and similar viral titers were measured in the nasal turbinates of infected ferrets. Pulmonary viral titers were not different between strains and pathological findings in the lungs were similar in severity. VN1203 replicated to high titers in the olfactory bulb, cerebral cortex, and brain stem; whereas HK483 was not recovered in these tissues. VN1203 was identified adjacent to and within the olfactory nerve tract, and multifocal infection was observed throughout the frontal cortex and cerebrum. VN1203 was also detected throughout the cerebellum, specifically in Purkinje cells and regions that coordinate voluntary movements. These findings suggest the increased lethality of VN1203 in ferrets is due to increased replication in brain regions important in higher order function and explains the neurological signs observed during H5N1 neurovirulence.

  11. Hong Kong Dreams and Disney Fantasies: How Hong Kong Disneyland (Controversially) Indigenizes Space, Labor, and Consumption

    OpenAIRE

    Banh, Jenny

    2013-01-01

    ABSTRACT OF THE DISSERTATIONHong Kong Dreams and Disney Fantasies: How Hong Kong Disneyland (Controversially) Indigenizes Space, Labor, and ConsumptionbyJenny BanhDoctor of Philosophy, Graduate Program in Anthropology University of California, RiversideDr. Yolanda Moses, ChairpersonIn 2005, Hong Kong imported the ultimate piece of Americana - Disneyland: the globe's largest media company and themepark operator. This dissertation looks at how the Hong Kong Disneyland indigenizes in terms of Sp...

  12. Developments in Dance Education in Hong Kong

    Science.gov (United States)

    Street, Susan

    2002-01-01

    Three key publications from September 2000 point to rapid changes in the educational and arts environment in Hong Kong that will impact on the development of dance education. This paper provides some contextual details on the current state of dance education in Hong Kong and also examines the influence and possible ramifications implicit within…

  13. Historical Development of Hong Kong Sign Language

    Science.gov (United States)

    Sze, Felix; Lo, Connie; Lo, Lisa; Chu, Kenny

    2013-01-01

    This article traces the origins of Hong Kong Sign Language (hereafter HKSL) and its subsequent development in relation to the establishment of Deaf education in Hong Kong after World War II. We begin with a detailed description of the history of Deaf education with a particular focus on the role of sign language in such development. We then…

  14. Jmpressions of Langham Hotel Hong Kong

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Hong Kong has long been famous for its exquisite architecture and effective administration.Its hotels are no exception.Last week,we had a chance to experience the five-star Langham Hotel Hong Kong and learn about its design and management concepts,namely its unique characteristics and people-oriented services.

  15. The Preparation of Educational Psychologists in Hong Kong

    Science.gov (United States)

    Lam, Shui-fong

    2014-01-01

    Modeled after the British system, school psychologists in Hong Kong are called educational psychologists. Hong Kong is the first location in Asia to have a recognized specialty vocation in educational psychology and a program for their professional preparation. The first program in Hong Kong, established by the University of Hong Kong in 1981…

  16. The Preparation of Educational Psychologists in Hong Kong

    Science.gov (United States)

    Lam, Shui-fong

    2014-01-01

    Modeled after the British system, school psychologists in Hong Kong are called educational psychologists. Hong Kong is the first location in Asia to have a recognized specialty vocation in educational psychology and a program for their professional preparation. The first program in Hong Kong, established by the University of Hong Kong in 1981…

  17. Education Reform in Hong Kong

    Directory of Open Access Journals (Sweden)

    Chris Dowson

    2000-05-01

    Full Text Available Since the early 1990s, the pace of educational reform in Hong Kong has accelerated and broadened to incorporate almost all areas of schooling. The reforms introduced during this period can be subsumed under what has generally been labelled the quality movement. In this paper, we review and comment on a number of policy reform initiatives in the four areas of "Quality Education," English Language Benchmarking, Initial Teacher Training and the Integration of Pupils with Special Needs into Ordinary Classrooms. Following a brief description of each policy initiative, the reforms are discussed in terms of their consistency, coherence and cultural fit.

  18. The emergence of influenza A H7N9 in human beings 16 years after influenza A H5N1: a tale of two cities.

    Science.gov (United States)

    To, Kelvin K W; Chan, Jasper F W; Chen, Honglin; Li, Lanjuan; Yuen, Kwok-Yung

    2013-09-01

    Infection with either influenza A H5N1 virus in 1997 or avian influenza A H7N9 virus in 2013 caused severe pneumonia that did not respond to typical or atypical antimicrobial treatment, and resulted in high mortality. Both viruses are reassortants with internal genes derived from avian influenza A H9N2 viruses that circulate in Asian poultry. Both viruses have genetic markers of mammalian adaptation in their haemagglutinin and polymerase PB2 subunits, which enhanced binding to human-type receptors and improved replication in mammals, respectively. Hong Kong (affected by H5N1 in 1997) and Shanghai (affected by H7N9 in 2013) are two rapidly flourishing cosmopolitan megacities that were increasing in human population and poultry consumption before the outbreaks. Both cities are located along the avian migratory route at the Pearl River delta and Yangtze River delta. Whether the widespread use of the H5N1 vaccine in east Asia-with suboptimum biosecurity measures in live poultry markets and farms-predisposed to the emergence of H7N9 or other virus subtypes needs further investigation. Why H7N9 seems to be more readily transmitted from poultry to people than H5N1 is still unclear.

  19. Brief of Language education in Hong Kong

    Institute of Scientific and Technical Information of China (English)

    李超

    2014-01-01

    This paper discusses the current language education and issues in Hong Kong, The language apply maintain successfully the international and local identity needs in Hong Kong, both English and Cantonese are mainly in the different areas, meeting the different needs of various aspects of the mainstream language. Hong Kong was a multi-lingual region. English was the official language in more than one hundred years before Return;English enjoyed a dominant position in Hong Kong, where expression under the influence of English, Chinese and English code-switching is also very common. The Return of Hong Kong has a con-siderable influence to language phenomenon;greatly strengthen the importance of Mandarin. In this paper, from the Angle of so-cial linguistics, this paper discusses the English position before and after Hong Kong's return to China, discussing economic, busi-ness, education, and other areas of the social development and changes of English status, and analyzes the Hong Kong residents for English, Cantonese and Mandarin language attitude.

  20. Prehospital care in Hong Kong.

    Science.gov (United States)

    Lo, C B; Lai, K K; Mak, K P

    2000-09-01

    A quick and efficient prehospital emergency response depends on immediate ambulance dispatch, patient assessment, triage, and transport to hospital. During 1999, the Ambulance Command of the Hong Kong Fire Services Department responded to 484,923 calls, which corresponds to 1329 calls each day. Cooperation between the Fire Services Department and the Hospital Authority exists at the levels of professional training of emergency medical personnel, quality assurance, and a coordinated disaster response. In response to the incident at the Hong Kong International Airport in the summer of 1999, when an aircraft overturned during landing, the pre-set quota system was implemented to send patients to designated accident and emergency departments. Furthermore, the 'first crew at the scene' model has been adopted, whereby the command is established and triage process started by the first ambulance crew members to reach the scene. The development of emergency protocols should be accompanied by good field-to-hospital and interhospital communication, the upgrading of decision-making skills, a good monitoring and auditing structure, and commitment to training and skills maintenance.

  1. Influenza H5N1 and H1N1 virus replication and innate immune responses in bronchial epithelial cells are influenced by the state of differentiation.

    Directory of Open Access Journals (Sweden)

    Renee W Y Chan

    Full Text Available Influenza H5N1 virus continues to be enzootic in poultry and transmits zoonotically to humans. Although a swine-origin H1N1 virus has emerged to become pandemic, its virulence for humans remains modest in comparison to that seen in zoonotic H5N1 disease. As human respiratory epithelium is the primary target cells for influenza viruses, elucidating the viral tropism and host innate immune responses of influenza H5N1 virus in human bronchial epithelium may help to understand the pathogenesis. Here we established primary culture of undifferentiated and well differentiated normal human bronchial epithelial (NHBE cells and infected with highly pathogenic influenza H5N1 virus (A/Vietnam/3046/2004 and a seasonal influenza H1N1 virus (A/Hong Kong/54/1998, the viral replication kinetics and cytokine and chemokine responses were compared by qPCR and ELISA. We found that the in vitro culture of the well differentiated NHBE cells acquired the physiological properties of normal human bronchi tissue which express high level of alpha2-6-linked sialic acid receptors and human airway trypsin-like (HAT protease, in contrast to the low expression in the non-differentiated NHBE cells. When compared to H1N1 virus, the H5N1 virus replicated more efficiently and induced a stronger type I interferon response in the undifferentiated NHBE cells. In contrast, in well differentiated cultures, H5N1 virus replication was less efficient and elicited a lower interferon-beta response in comparison with H1N1 virus. Our data suggest that the differentiation of bronchial epithelial cells has a major influence in cells' permissiveness to human H1N1 and avian H5N1 viruses and the host innate immune responses. The reduced virus replication efficiency partially accounts for the lower interferon-beta responses in influenza H5N1 virus infected well differentiated NHBE cells. Since influenza infection in the bronchial epithelium will lead to tissue damage and associate with the

  2. Avian influenza vaccines against H5N1 'bird flu'.

    Science.gov (United States)

    Li, Chengjun; Bu, Zhigao; Chen, Hualan

    2014-03-01

    H5N1 avian influenza viruses (AIVs) have spread widely to more than 60 countries spanning three continents. To control the disease, vaccination of poultry is implemented in many of the affected countries, especially in those where H5N1 viruses have become enzootic in poultry and wild birds. Recently, considerable progress has been made toward the development of novel avian influenza (AI) vaccines, especially recombinant virus vector vaccines and DNA vaccines. Here, we will discuss the recent advances in vaccine development and use against H5N1 AIV in poultry. Understanding the properties of the available, novel vaccines will allow for the establishment of rational vaccination protocols, which in turn will help the effective control and prevention of H5N1 AI.

  3. Air quality strategy for Hong Kong

    Energy Technology Data Exchange (ETDEWEB)

    Alex, N.K.Y. [Air Policy Group, Wanchai (Hong Kong). Environmental Protection Dept.

    1995-12-31

    Hong Kong has experienced unimpeded economic growth for four decades but at the same time has suffered from growing air pollution. A new look at the air quality strategy is therefore required to bring about sustainable development. (author)

  4. Greenhouse gas emissions in Hong Kong

    Science.gov (United States)

    Leung, D. Y. C.; Lee, Y. T.

    This study provides a quantitative review of the emissions of carbon dioxide (CO 2) and methane (CH 4), the two most significant greenhouse gases (GHGs) in Hong Kong. Study indicated that CO 2 accounts for 90% of the local GHG emissions in Hong Kong. Among the different types of fuels coal is identified as the major source of CO 2, which constitutes about 50% by fuel type. On the other hand, CH 4, which mainly comes from waste decomposition, contributes to 5% of the total GHG emissions. Correlation study revealed that energy consumption and waste quantity were strongly correlated with population and gross domestic products (GDP), implying that not much has been done in Hong Kong to re-mediate GHG emissions. Regression analysis concluded that supply side management (fuel switch) was more effective than demand side management (energy conservation) in mitigating CO 2 emissions in Hong Kong.

  5. Protection of Minors in Hong Kong

    Institute of Scientific and Technical Information of China (English)

    CAO WEI

    2007-01-01

    @@ Ⅰ. Laws and systems 1. Laws There is no unified law or regulation in Hong Kong devoted to the protection of minors. The provisions concerning the protection of minors are reflected in many ordinances. Chapter 226 of Hong Kong Laws: Juvenile Offenders Ordinance says:It shall be conclusively presumed that no child under the age of 10 years can be guilty of an offence.

  6. Hong Kong is the First Choice

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    The Support of the Industry The major shows held in Hong Kong, out of the 70 annual ones, are mainly trade fairs for consumer products--fashion, giftware, jewelery, consumer electronics, watches, optical and the like. Most of the manufacturing factories of these products are located in the PRD region, many of which are invested by Hong

  7. 一株H5N1亚型禽流感病毒全基因组克隆及HA基因分子进化分析%Cloning and sequencing full-length genome of H5N1 avian influenza A virus and molecular evolution analysis of HA gene

    Institute of Scientific and Technical Information of China (English)

    徐军强; 吴叔文; 詹发先; 喻明霞; 江永忠; 霍细香

    2011-01-01

    Objective To clone and sequence full-length genome of the avian influenza A/Chicken/Hubei/489/ 2004(H5N1 ) virus,in order to analyze genetic mutation patterns of HA gene and polygenetic relationship between A/ Chicken/Hubei/489/2OO4(H5Nl) virus and other strains since 1996. Methods 8 genes of the avian influenza A/ Chicken/Hubei/489/2004 ( H5N1 ) virus were amplified and cloned, and then genetic mutation analysis and phylogenetic trees were made by bioinformatics software. Results Full-length genome of the avian influenza A/ Chicken/Hubei/489/2004(H5N1)virus were cloned into the vector of PMD18-T. Genetic evolution analysis showed that there is a specific cleavage site of "PQRERRRKKR" , which was proved be related with virulence. In addition, molecular phylogenetic trees of HA gene revealed that A/Chicken/Hubei/ 489/2004 virus were closely related to HSN1 viruses of 2000-2006 isolated in Hong Kong and in Southeast Asia. Conclusion the influenza A/Chicken/ Hubei/489/2004 ( H5N1) virus was closest genetic relatives to the influenza A/Chicken/HongKong/YU777/2002 (H5N1) virus, and it was most possible that the avian influenza outbreak was caused by the 2002 lineage of Hong Kong.%目的 对禽流感H5N1亚型病毒株A/Chicken/Hubei/489/2004的全基因组进行克隆和测序,并分析血凝素基因HA的遗传突变特点及其与1996年以来其他病毒株的亲缘关系.方法 通过RT-PCR扩增病毒株A/C hicken/Hubei/489/2004的8个基因,并将其克隆到测序载体;在对病毒株全基因组序列测定基础上,利用生物信息学软件对HA基因进行遗传进化分析.结果 病毒株A/Chicken/Hubei/489/2004的全基因组克隆到PMD18-T;遗传进化分析显示该毒株HA蛋白具有与致病性有关的切割位点“PQRERRRKKR”,并且与2000~2006年在香港从人和禽体内分离的H5N1亲缘关系相近,也与2003~2004年在东南亚从人和禽体内分离的H5N1极其相关.结论 A/Chicken/H ubei/489/2004病毒分离株具有与A/Chicken/Hong

  8. A model to control the epidemic of H5N1 influenza at the source

    Directory of Open Access Journals (Sweden)

    Li KS

    2007-11-01

    Full Text Available Abstract Background No country is fully prepared for a 1918-like pandemic influenza. Averting a pandemic of H5N1 influenza virus depends on the successful control of its endemicity, outbreaks in poultry and occasional spillage into human which carries a case-fatality rate of over 50%. The use of perimetric depopulation and vaccination has failed to halt the spread of the epidemic. Blanket vaccination for all poultry over a large geographical area is difficult. A combination of moratorium, segregation of water fowls from chickens and vaccination have been proved to be effective in the Hong Kong Special Administrative Region (HKSAR since 2002 despite endemicity and outbreaks in neighbouring regions. Systematic surveillance in southern China showed that ducks and geese are the primary reservoirs which transmit the virus to chickens, minor poultry and even migratory birds. Presentation of the hypothesis We hypothesize that this combination of moratorium, poultry segregation and targeted vaccination if successfully adapted to an affected district or province in any geographical region with high endemicity would set an example for the control in other regions. Testing the hypothesis A planned one-off moratorium of 3 weeks at the hottest month of the year should decrease the environmental burden as a source of re-infection. Backyard farms will then be re-populated by hatchlings from virus-free chickens and minor poultry only. Targeted immunization of the ducks and geese present only in the industrial farms and also the chickens would be strictly implemented as blanket immunization of all backyard poultry is almost impossible. Freely grazing ducks and geese would not be allowed until neutralizing antibodies of H5 subtype virus is achieved. As a proof of concept, a simple mathematical model with susceptible-infected-recovered (SIR structure of coupled epidemics between aquatic birds (mainly ducks and geese and chickens was used to estimate

  9. Is corporate Hong Kong ready for the green economy?

    OpenAIRE

    Association of Chartered Certified Accountants

    2012-01-01

    This report summarises the ACCA and WWF Hong Kong roundtable held in Hong Kong on 27 June 2012, one of a series of events addressing sustainability issues relevant to the business community in Asia. Publisher PDF

  10. College Psychotherapy at a Hong Kong Counseling Center

    Science.gov (United States)

    Leung, Eugenie Y.

    2013-01-01

    This article presents an online interview about college psychotherapy at a Hong Kong counseling center. The interview discusses how students generally feel about going for counseling or therapy and how common it is in Hong Kong.

  11. Disneyland in Hong Kong — Green Challenge (A)

    OpenAIRE

    Terence Tsai; Shubo Philip Liu

    2011-01-01

    In mid-1999, the Walt Disney Company and the Hong Kong Government were involved in intense discussions about the possibility of building the Hong Kong Disneyland theme park on Lantau Island. This case presented detailed information about the proposed theme park and the associated decision making process with a particular emphasis on sustainable development. It also lays out the characteristics of the Hong Kong Government and Hong Kong people that might have played a role in decision making.Th...

  12. Intra-Nationalization of Higher Education: The Hong Kong Case

    Science.gov (United States)

    Chao, Roger Y.

    2012-01-01

    This paper explores the internationalization of higher education initiatives of Hong Kong, being one of the Special Administrative Regions (SAR) of China, within the context of the Chinese Mainland-Hong Kong (CM-HK) relations. Historical, social, economic, and political ties between Hong Kong and the Mainland of China, their economic and political…

  13. Hong Kong Fashion Week Spring/Summer Unveiled Trend Forecast

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    The 19th Hong Kong Fashion Week for Spring/Summer, organized by the Hong Kong Trade Development Council (HKTDC), kicked off its four-day run on 3 July, 2012 at the Hong Kong Convention and Exhibition Centre.

  14. Hong Kong Disney:A Paradise in Your Dream

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    @@ A paradise dream will become true! That's Hong Kong Disney! On June 3,there was magic at work at Hong Kong Disneyland today as hundreds of cast members, together with Hong Kong Disneyland Ambassador Angela To, celebrated the start of the 100-day countdown to the Park's grand opening on September 12.

  15. H5N1 avian influenza in China

    Institute of Scientific and Technical Information of China (English)

    CHEN HuaLan

    2009-01-01

    H5N1 highly pathogenic avian influenza virus was first detected in a goose in Guangdong Province of China in 1996. Multiple genotypes of H5N1 viruses have been identified from apparently healthy wa-terfowl since 1999. In the years 2004-2008, over 100 outbreaks in domestic poultry occurred in 23 provinces and caused severe economic damage to the poultry industry in China. Beginning from 2004, a culling plus vaccination strategy has been implemented for the control of epidemics. Since then, over 35420000 poultry have been depopulated, and over 55 billion doses of the different vaccines have been used to control the outbreaks. Although it is logistically impossible to vaccinate every single bird in China due to the large poultry population and the complicated rearing styles, there is no doubt that the increased vaccination coverage has resulted in decreased disease epidemic and environmental virus loading. The experience in China suggests that vaccination has played an important role in the protec-tion of poultry from H5N1 virus infection, the reduction of virus load in the environment, and the pre-vention of H5N1 virus transmission from poultry to humans.

  16. H5N1 avian influenza in China

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    H5N1 highly pathogenic avian influenza virus was first detected in a goose in Guangdong Province of China in 1996. Multiple genotypes of H5N1 viruses have been identified from apparently healthy waterfowl since 1999. In the years 2004-2008, over 100 outbreaks in domestic poultry occurred in 23 provinces and caused severe economic damage to the poultry industry in China. Beginning from 2004, a culling plus vaccination strategy has been implemented for the control of epidemics. Since then, over 35420000 poultry have been depopulated, and over 55 billion doses of the different vaccines have been used to control the outbreaks. Although it is logistically impossible to vaccinate every single bird in China due to the large poultry population and the complicated rearing styles, there is no doubt that the increased vaccination coverage has resulted in decreased disease epidemic and environmental virus loading. The experience in China suggests that vaccination has played an important role in the protection of poultry from H5N1 virus infection, the reduction of virus load in the environment, and the prevention of H5N1 virus transmission from poultry to humans.

  17. The historical role of demographic change in Hong Kong.

    Science.gov (United States)

    Yang, Z

    1996-01-01

    In the aftermath of the Opium War, Britain coerced the Manchurian government into signing three treaties under which Britain occupied and leased the territory of Hong Kong and established colonial rule in the region. The rapid development of Hong Kong over the past 30 years has resulted in an increase of the territory's population from 5650 in 1841 to 6,149,000 at the end of 1994. Hong Kong now ranks fourth among the global financial centers, sixth in global foreign exchange reserve, and eighth among the world's trade systems, with per capita output of US$21,760. Demographic change and an exceptional development model were instrumental in building Hong Kong into what it has become. This paper discusses successful demographic transformation as the milestone of Hong Kong's social development, population growth as the basis of the Hong Kong government's economic strategy, and a modernized population management system as an important condition for the smooth transition of Hong Kong.

  18. The Quality of Life in Hong Kong

    Science.gov (United States)

    Sing, Ming

    2009-01-01

    The AsiaBarometer of 1,000 respondents shows that Hong Kong people have a great desire for materialistic attainment, and such an emphasis on materialism bodes ill for their quality of life. Negative assessments of the public life sphere, which encompasses the natural environment, the social welfare system, and the democratic system, also detract…

  19. Intraseasonal variation of visibility in Hong Kong

    Science.gov (United States)

    Zhou, Wen; Li, Richard C. Y.; Chow, Eric C. H.

    2017-01-01

    Visibility is one of the parameters for indicating air pollution. In this study, visibility variation in Hong Kong during summer and winter is investigated. Visibility in Hong Kong has clear intraseasonal variation. Examination of different environmental parameters suggests that the intraseasonal component dominates the overall circulation anomalies in both summer and winter. Associated with the intraseasonal variation of environmental parameters, obvious variation in visibility impairment is found in both summer and winter. In summer, local visibility and air quality are found to be significantly affected by the (MJO) and the 10-30-day intraseasonal oscillation (ISO) through modulation of associated atmospheric circulations. In winter, the modulation effects appear to be weaker due to the southward shift of the associated convection. The results in this study highlight the importance of the ISO in contributing to the overall variation in visibility in Hong Kong, and provide useful implications for the development of possible mitigation strategies associated with visibility impairment and air pollution in Hong Kong.

  20. Sibling Incest: A Hong Kong Experience.

    Science.gov (United States)

    Tsun, O. K. Angela

    1999-01-01

    Presents a case study of a Hong Kong Chinese adult survivor of brother-sister incest. Discusses her symptoms, feelings toward incest, parental response at disclosures, and implications for practice. Also discusses Chinese cultural influences that affect the family and lead to secrecy and shame. (CR)

  1. Avian influenza a (H5N1): A preliminary review

    OpenAIRE

    Padhi S.; Panigrahi P; Mahapatra A; Mahapatra S

    2004-01-01

    Humanity has been at the receiving end of many viral diseases since ages. Sudden emergence and re-emergence of new viral diseases in human beings has surprised the medical scientists from time to time. "Avian influenza" or "Bird flu" by H5N1 epidemics is one such surprise. Although many aspects about this disease are clear, there are some dark areas regarding vaccine development that need to be further explored and understood, so as to effectively contain the spread of this disease. The prese...

  2. Avian influenza a (H5N1: A preliminary review

    Directory of Open Access Journals (Sweden)

    Padhi S

    2004-01-01

    Full Text Available Humanity has been at the receiving end of many viral diseases since ages. Sudden emergence and re-emergence of new viral diseases in human beings has surprised the medical scientists from time to time. "Avian influenza" or "Bird flu" by H5N1 epidemics is one such surprise. Although many aspects about this disease are clear, there are some dark areas regarding vaccine development that need to be further explored and understood, so as to effectively contain the spread of this disease. The present article details out almost everything known about this interesting disease along with the review of the recent literature.

  3. Rehabilitation for Young Offenders in Hong Kong Correctional Institutions

    Science.gov (United States)

    Tam, Kai Yung; Heng, Mary Anne

    2008-01-01

    The motto of the Hong Kong Correctional Services Department (CSD) is to "Support Rehabilitative Offenders for a More Inclusive Society." The Hong Kong CSD has developed a correctional system which has placed increasing emphasis on correction and rehabilitation of offenders over the years. This paper describes the efforts of the Hong Kong…

  4. Ayuntamiento de Hong-Kong

    Directory of Open Access Journals (Sweden)

    Fitch, A.

    1963-11-01

    Full Text Available This town hall comprises five buildings, each with a particular function, but all expressing a mutual coherence and architectural unity. The main building features a large entrance hall, leading to the concert hall and the theatre. On the first floor there is a dancing hall with accommodation for 500 people. The banquet hall can seat 500, it is situated on the second floor, and is fitted to supply both Chinese and European food. It can operate as an ordinary restaurant. The concert hall has been designed for an audience of 1,500, with a stage suitable for an orchestra of 100 players and 120 dancers. Although its primary purpose is the holding of symphony concerts, it can be adapted to Chinese opera and other types of stage displays. The theatre has 467 seats, and its acoustical properties are such that chamber music can also be performed in it. Another building of this project is a 12 storey tower. On the lower floor weddings and civil ceremonies are held. There are libraries on the second and sixth floors. An exhibition hall occupies the seventh floor. On the eighth there are two lecture rooms, and on the ninth offices and a workshop. A museum and an art gallery take up the tenth and eleventh floors. The air conditioning installations, engine room and other ancillary services are situated on the top of the building. Part of the project includes a garden commemorating the Hong-Kong volunteers who died in the period 1941-45: it stands on an elevated site, and a polygonal shaped chapel completes this memorial. On the outside the tower is faced in marble, whilst the concert hall walls are in polished granite. A sole of blue enamelled brick extends along the whole perimeter of the central block, including the wall surrounding the memorial garden.Comprende un grupo de cinco edificios dedicados a fines diversos, pero a. los que se les ha imprimido una coherencia y unidad que aumenta su valor individual. La edificación principal presenta el gran hall

  5. Characterization of avian influenza H5N1 virosome

    Directory of Open Access Journals (Sweden)

    Chatchai Sarachai

    2014-04-01

    Full Text Available The purpose of this study was to prepare and characterize virosome containing envelope proteins of the avian influenza (H5N1 virus. The virosome was prepared by the solubilization of virus with octaethyleneglycol mono (n-dodecyl ether (C12E8 followed by detergent removal with SM2 Bio-Beads. Biochemical analysis by SDS-PAGE and western blotting, indicated that avian influenza H5N1 virosome had similar characteristics to the parent virus and contained both the hemagglutinin (HA, 60-75 kDa and neuraminidase (NA, 220 kDa protein, with preserved biological activity, such as hemagglutination activity. The virosome structure was analyzed by negative stained transmission electron microscope (TEM demonstrated that the spherical shapes of vesicles with surface glycoprotein spikes were harbored. In conclusion, the biophysical properties of the virosome were similar to the parent virus, and the use of octaethyleneglycol mono (n-dodecyl ether to solubilize viral membrane, followed by removal of detergent using polymer beads adsorption (Bio-Beads SM2 was the preferable method for obtaining avian influenza virosome. The outcome of this study might be useful for further development veterinary virus vaccines.

  6. CEPA and interrelationship between Chinese yuan and Hong Kong dollar

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    In order to explore the interrelated impacts of the economical communications between China and Hong Kong SAR, especially after the closer economic partnership arrangement (CEPA) and the Chinese yuan offshore financial business in Hong Kong banks in 2004, the exchange rates of the Chinese yuan and the Hong Kong dollar are investigated as well-performing market signals that should reflect this historical transformation. With vector autoregressive models (VAR), the Johansen cointegration test and the Granger ...

  7. Sources of Hong Kong Civil Legal Proceedings Legal Regulation

    Directory of Open Access Journals (Sweden)

    Elena P. Ermakova

    2014-06-01

    Full Text Available In the present article author gives characteristic of the civil legal proceedings sources of legal regulation in Hong Kong: statute law, delegated legislation, general law, the Chinese common law. System of the Hong Kong law sources completely corresponds to the system of England civil procedural law sources. Till June 30, 1997 Hong Kong was a colony of the Great Britain. Since 1997 Hong Kong became a special administrative region of the People's Republic of China (PRC. Laws of Hong Kong on courts, on proofs, on the legal aid, on administration of justice contain references to the corresponding English legal acts. The feature of the Hong Kong legal system is due to the fact that Hong Kong Basic Law of 1990 sets on the territory of the country a simultaneous action of two systems of the legislation until 2047: legislation of Hong Kong created before 1997 under the influence Great Britain and legislation of People's Republic of China which regulates questions of foreign policy and country’s defense. The list of sources of the civil procedural law of Hong Kong includes: 1 statute law; 2 delegated legislation (rule of courts; 3 general law (precedents. Author gives opinions of jurists and practicians both from China, and from other countries, present own definitions and justifications.

  8. Slimming company websites in Hong Kong: implications for women's health.

    Science.gov (United States)

    Chan, Zenobia C Y; Lai, Wing-Fu

    2011-07-01

    This study sought to investigate, with a focus on the Hong Kong context, how commercial slimming websites portray the body image of beauty to the public, and to explore practical implications for related public health practices and health policy formulation. Commercial entities in the Hong Kong slimming industry were retrieved from the Hong Kong Yellow Page Directory and Yahoo Hong Kong Directory, and selected websites were coded and further analyzed. We found that irresponsible tactics are used in the slimming industry such that irresponsible messages prevail. Collaborative efforts from multidisciplinary sectors are needed to tackle the situation.

  9. A Hong Kong Woman on Teaching

    Institute of Scientific and Technical Information of China (English)

    1999-01-01

    "SHE has black hair,very beautiful eyes and a smile alwaysplaying on her lips,"sixth-grade Pan Yong wrote in his diary.Hewas describing his teacher,Zhou Kefan,a young Hong Kong womanwho came to teach for half a year in the mainland’s southern remotemountains inhabited by the Yao people. A graduate of the preparatory course from Hong Kong LiBaochun United International Academy of Classical Learning,ZhouKefan has been a good scholar with an agreeable demeanor since shewas little.Just as she had decided to go to the United States to studyfurthe,a voluntary teaching position on the mainland made herchange her mind. A long-term help and support to the Nangang Primary School in

  10. Breast milk substitutes in Hong Kong.

    Science.gov (United States)

    Nelson, E A S; Chan, C W; Yu, C M

    2004-07-01

    In 1981 the World Health Assembly (WHA) adopted the International Code of Marketing of Breast Milk Substitutes (the Code) to support breastfeeding. Despite improving trends, Hong Kong has low rates of breastfeeding compared to other developed countries. We surveyed companies marketing breast milk substitutes in Hong Kong to determine self-reported adherence to the Code. Companies were informed that individual responses would not be published and seven of nine companies responded to the questionnaire. The majority of respondents promoted infant and follow-on formula in hospitals and provided free supplies of infant formula to hospitals. Follow-on formula and weaning foods were promoted in shops and to the general public and free samples were given to mothers reflecting a belief that, despite WHA resolutions, follow-on formula is not a breast milk substitute. Transnational companies should follow the Code and subsequent WHA resolutions equally in all countries.

  11. Aetiology of allergic rhinitis in Hong Kong

    Directory of Open Access Journals (Sweden)

    Christopher W.K. Lam

    1998-01-01

    Full Text Available In a 1993 survey, allergic rhinitis was identified as the most common allergic disease in Hong Kong, affecting 29.1% of schoolchildren. Recently (1995, the International Study of Asthma and Allergies in Childhood (ISAAC also reported 44.5% current rhinitis among Hong Kong teenagers. Our objective was to study the aetiology of allergic rhinitis in Hong Kong using serological tests of allergen sensitization. In 57 allergic rhinitis patients and in the same number of age- and sex-matched controls the following were measured: serum total IgE, mixed aeroallergen IgE (Phadiatop™ and specific IgE versus house dust mite (HDM, cockroach, cat and dog dander, mould mixture (Penicillium, Cladosporium, Aspergillus and Alternaria species and four local pollens (Bermuda grass, Timothy, ragweed and mugwort. Compared with controls, allergic rhinitis patients (26 males, 31 females; mean (± SD age 25 ±11 years had a significantly elevated serum total IgE concentration (mean ± SEM: 496 ± 88 vs 179 ± 38 kU/L and an increased proportion of positive Phadiatop (95 vs 33% and specific IgE tests versus HDM (90 vs 44% and cockroach (42 vs 9%; Mann-Whitney U-test and χ2 tests all P < 0.005. There was no significant difference in sensitization to other allergens tested. House dust mite and cockroach are ubiquitous in Hong Kong with a warm, humid climate and crowded living conditions. Their identification as aetiological agents of allergic rhinitis should help in the development of environmental strategies for reducing the inhalant allergen load to prevent and control this prevalent and costly health problem in our community.

  12. Silver-Russell syndrome in Hong Kong.

    Science.gov (United States)

    Luk, H M; Yeung, K S; Wong, W L; Chung, B Hy; Tong, T Mf; Lo, I Fm

    2016-12-01

    To examine the molecular pathogenetic mechanisms, (epi)genotype-phenotype correlation, and the performance of the three clinical scoring systems-namely Netchine et al, Bartholdi et al, and Birmingham scores-for patients with Silver-Russell syndrome in Hong Kong. This retrospective case series was conducted at two tertiary genetic clinics, the Clinical Genetic Service, Department of Health, and clinical genetic clinic in Queen Mary Hospital in Hong Kong. All records of patients with suspected Silver-Russell syndrome under the care of the two genetic clinics between January 2010 and September 2015 were retrieved from the computer database. Of the 28 live-birth patients with Silver-Russell syndrome, 35.7% had H19 loss of DNA methylation, 21.4% had maternal uniparental disomy of chromosome 7, 3.6% had mosaic maternal uniparental disomy of chromosome 11, and the remaining 39.3% were Silver-Russell syndrome of unexplained molecular origin. No significant correlation between (epi)genotype and phenotype could be identified between H19 loss of DNA methylation and maternal uniparental disomy of chromosome 7. Comparison of molecularly confirmed patients and patients with Silver-Russell syndrome of unexplained origin revealed that postnatal microcephaly and café-au-lait spots were more common in the latter group, and body and limb asymmetry was more common in the former group. Performance analysis showed the Netchine et al and Birmingham scoring systems had similar sensitivity in identifying Hong Kong Chinese subjects with Silver-Russell syndrome. This is the first territory-wide study of Silver-Russell syndrome in Hong Kong. The clinical features and the spectrum of underlying epigenetic defects were comparable to those reported in western populations.

  13. Families and family therapy in Hong Kong.

    Science.gov (United States)

    Tse, Samson; Ng, Roger M K; Tonsing, Kareen N; Ran, Maosheng

    2012-04-01

    Family therapy views humans not as separate entities, but as embedded in a network of relationships, highlighting the reciprocal influences of one's behaviours on one another. This article gives an overview of family demographics and the implementation of family therapy in Hong Kong. We start with a review of the family demographics in Hong Kong and brief notes on families in mainland China. Demographics show that the landscape has changed markedly in the past decade, with more cross-border marriages, an increased divorce rate, and an ageing overall population - all of which could mean that there is increasing demand for professional family therapy interventions. However, only a limited number of professionals are practising the systems-based approach in Hong Kong. Some possible reasons as to why family therapy is not well disseminated and practised are discussed. These reasons include a lack of mental health policy to support family therapy, a lack of systematic family therapy training, and a shortage of skilled professionals. Furthermore, challenges in applying the western model in Chinese culture are also outlined. We conclude that more future research is warranted to investigate how family therapy can be adapted for Chinese families.

  14. A Case Study of Language Policies in Hong Kong

    Institute of Scientific and Technical Information of China (English)

    朱玲玲

    2015-01-01

    Hong Kong belongs to China. However, Hong Kong has been a colony of the British Empire for 154 years and 11 months and it has been under Japan rule for three years and eight years. Hong Kong returned to China in 1997. Its special histo⁃ry has significant influence on the language development in Hong Kong. During the period of British Empire, the popularity of Christianity, the commercial usefulness of English and high prestige in the society have resulted in the widely spread of English. In addition, English-medium education is in a relatively high state under the colonial regime while Chinese-medium education to some extent is not emphasized. The government has ruled that if parents would like their children to be educated in a good government school, they need to receive English-medium education. Consequently, the majority of parents would like their chil⁃dren to be educated by English. Apart from that, English has a legal status as an official language during British Colonialism period in Hong Kong. Lastly, some scholars supported the existence of a new English variety in Hong Kong (Hong Kong English), but others do not believe that. The requirements of language policies and the process of language spread in Hong Kong could be ex⁃plained using some theories such as‘linguistic imperialism’,‘Kachru’s concentric circles’and‘Schneider’s five stages’. For in⁃stance, from Kachru’s perspective, the development of English in Hong Kong could be placed at the beginning of the third stage. It will firstly demonstrate some primary language policies in Hong Kong before its‘Handover’to China. And then, it will show several significant language spread theories and focus on relating them to the requirements of language policies and the process of language spread in Hong Kong.

  15. Hong kong chemical waste treatment facilities: a technology overview

    Energy Technology Data Exchange (ETDEWEB)

    Siuwang, Chu [Enviropace Ltd., Hong Kong (Hong Kong)

    1993-12-31

    The effective management of chemical and industrial wastes represents one of the most pressing environmental problems confronting the Hong Kong community. In 1990, the Hong Kong government contracted Enviropace Limited for the design, construction and operation of a Chemical Waste Treatment Facility. The treatment and disposal processes, their integration and management are the subject of discussion in this paper

  16. Hong Kong Perspectives on Educational Technology Research and Practice

    Science.gov (United States)

    Spector, J. Michael; Yuen, H. K.; Wang, Minhong; Churchill, Daniel; Law, Nancy

    2014-01-01

    This is the 25th anniversary of the Hong Kong Association for Educational Communications and Technology (HKAECT; see http://www.hkaect.org/). The silver anniversary annual meeting will be held at the University of Hong Kong December 8--10, with the theme of the conference being "Communication and Education: New Media, Knowledge Practices, and…

  17. Hong Kong Perspectives on Educational Technology Research and Practice

    Science.gov (United States)

    Spector, J. Michael; Yuen, H. K.; Wang, Minhong; Churchill, Daniel; Law, Nancy

    2014-01-01

    This is the 25th anniversary of the Hong Kong Association for Educational Communications and Technology (HKAECT; see http://www.hkaect.org/). The silver anniversary annual meeting will be held at the University of Hong Kong December 8--10, with the theme of the conference being "Communication and Education: New Media, Knowledge Practices, and…

  18. Inclusive Education Policy in the Hong Kong Primary Music Classroom

    Science.gov (United States)

    Wong, Marina Wai-yee; Chik, Maria Pik-yuk

    2016-01-01

    An education reform policy and inclusive education policy have been implemented in Hong Kong for over a decade. As more students with special educational needs have entered the mainstream education system under these policies, Hong Kong's primary music classrooms offer a site where three policies interact--the education reform policy entitled…

  19. Imperialism and the English Language in Hong Kong.

    Science.gov (United States)

    Boyle, Joseph

    1997-01-01

    Considers whether the charge of linguistic imperialism can be appropriately leveled against the British government during its colonial rule of Hong Kong. The article analyzes the concept of linguistic imperialism, considers landmarks in the history of the English language in Hong Kong, and applies the concept of linguistic imperialism to the…

  20. Family Effects on Student Achievement in Hong Kong

    Science.gov (United States)

    Chiu, Ming Ming; Ho, Esther Sui Chu

    2006-01-01

    We examine the effects of family structures and processes on student achievement in Hong Kong. Specifically, we show that the negative effects of single parenthood in past studies are not universal. In Hong Kong, 4,405 15-year-old students completed a questionnaire, and tests in reading, mathematics and science. We analysed the data using…

  1. School Experience of Chinese Sexual Minority Students in Hong Kong

    Science.gov (United States)

    Kwok, Diana K.

    2016-01-01

    Heterosexism faced by sexual minority (lesbian, gay, bisexual, and queer/questioning [LGBQ]) students has been extensively studied internationally in the past 2 decades but has only recently received attention from Hong Kong Chinese society. Chinese LGBQ students are not guaranteed to be included in Hong Kong schools, where antidiscrimination…

  2. Kowloon Shangri-La,Hong Kong Launches New Limousine Fleet

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    In its constant pursuit to offer the highest level of services and luxury to its guests, Kowloon Shangri-La, Hong Kong has launched a new fleet of limousines, including seven bespoke Mercedes-Benz S350L Series sedans and two five-seat Viano vans. Together with the two existing seven-seat vans, Kowloon Shangri-La, Hong Kong

  3. On-line geological memoir of Hong Kong

    Institute of Scientific and Technical Information of China (English)

    C W Lee; R J Sewell

    2007-01-01

    @@ Introduction The Geotechnical Engineering Office (GEO)of the Civil Engineering and DevelopmentDepartment (CEDD), Hong Kong SpecialAdministrative Region (HKSAR), China,has recently published an internet version ofthe geology of Hong Kong which is intendedto make the available geological informationmore accessible to the local and internationalcommunities.

  4. Transforming Hong Kong's Schools: Trends and Emerging Issues.

    Science.gov (United States)

    Dimmock, Clive; Walker, Allan

    1998-01-01

    Outlines three 1990s reforms in Hong Kong affecting curriculum and management: the School Management Initiative, the target-oriented curriculum, and an education commission report on quality education. Reviews reforms' effects and discusses the need to reorient the current school-based management system and recognize Hong Kong's societal culture.…

  5. Press Ideology and Organizational Control in Hong Kong.

    Science.gov (United States)

    Chan, Joseph Man; Lee, Chin-Chuan

    1988-01-01

    Surveys the entire Chinese journalist population of Hong Kong to determine how news organizations in the highly politicized environment of Hong Kong exercise institutional control on recruitment and newswork. Finds that press ideology is a major determinant of its organizational control. (MS)

  6. Political Participation : A qualitative study of citizens in Hong Kong

    OpenAIRE

    Bergström, Liza

    2006-01-01

    Abstract “Political participation” - A qualitative study of citizens in Hong Kong Thesis in Political Science, D-level Author: Liza Bergström Tutor: Michele Micheletti On July 1, 1997 China resumed its sovereignty over Hong Kong. Ever since long before the handover until today scholars ask whether and how the changes in Hong Kong’s political status are affecting politics in Hong Kong. This paper is situated in this on-going academic debate. Its purpose is to investigate whether system changes...

  7. Hong Kong-Ideal Access For Mainland Enterprises

    Institute of Scientific and Technical Information of China (English)

    Guo Yan

    2009-01-01

    @@ With the deepen economic integration between mainland China and Hong Kong SAR,more and more mainland enterprises choose Hong Kong as their platform to enter the international market.At the end or 2008,more than 3,800 mainland enterprises have invested in Hong Kong with the total amount of US$20.7 billion;and mainland enterprises collected the investment in Hong Kong has reached the scale of 22.1 billion HKD.In March of 2009,The Management Method of Investment Abroad issued by Ministry of Commerce also provides the great convenience for mainland investors.China's Foreign Trade invited Ms.Wong Hoi Wan,Charmraine,Associate Director-General of Invest HK to introduce HK investment environment,the development of mainland enterprises in Hong Kong as well as the investment perspective.

  8. Evaluation of the antigenic relatedness and cross-protective immunity of the neuraminidase between human influenza A (H1N1) virus and highly pathogenic avian influenza A (H5N1) virus.

    Science.gov (United States)

    Lu, Xiuhua; Liu, Feng; Zeng, Hui; Sheu, Tiffany; Achenbach, Jenna E; Veguilla, Vic; Gubareva, Larisa V; Garten, Rebecca; Smith, Catherine; Yang, Hua; Stevens, James; Xu, Xiyan; Katz, Jacqueline M; Tumpey, Terrence M

    2014-04-01

    To determine the genetic and antigenic relatedness as well as the cross-protective immunity of human H1N1 and avian H5N1 influenza virus neuraminidase (NA), we immunized rabbits with either a baculovirus-expressed recombinant NA from A/Beijing/262/95 (BJ/262) H1N1 or A/Hong Kong/483/97 (HK/483) H5N1 virus. Cross-reactive antibody responses were evaluated by multiple serological assays and cross-protection against H5N1 virus challenge was evaluated in mice. In a neuraminidase inhibition (NI) test, the antisera exhibited substantial inhibition of NA activity of the homologous virus, but failed to inhibit the NA activity of heterologous virus. However, these antisera exhibited low levels of cross-reactivity measured by plaque size reduction, replication inhibition, single radial hemolysis, and ELISA assays. Passive immunization with HK/483 NA-specific antisera significantly reduced virus replication and disease, and afforded almost complete protection against lethal homologous virus challenge in mice. However, passive immunization with BJ/262 (H1N1) NA-specific antisera was ineffective at providing cross-protection against lethal H5N1 virus challenge and only slightly reduced weight loss. Substantial amino acid variation among the NA antigenic sites was observed between BJ/262 and HK/483 virus, which was consistent with the lack of cross-reactive NI activity by the antibody and limited cross-protective immunity in mice. These results show a strong correlation between the lack of cross-protective immunity and low structural similarities of NA from a human seasonal H1N1 virus and an avian H5N1 influenza virus.

  9. Influenza H5N1 Virus of Birds Surrounding H5N1 Human Cases Have Specific Characteristics on the Matrix Protein

    Directory of Open Access Journals (Sweden)

    NI LUH PUTU INDI DHARMAYANTI

    2011-06-01

    Full Text Available The H5N1 influenza virus in Indonesia has caused more than 100 people died due to the virus infections. Cases in humans were mostly due to the virus spread from the infected birds. This study characterized molecularly the H5N1 virus from birds around the H5N1 infection cases in humans in Indonesia. Result from this study revealed that in several cases, waterfowl species could become the source of H5N1 infections in human. We found that the one of six viruses used in this study probably was a first antigenic shift virus in Indonesia. This study shows that the AI viruses isolated from birds around humans infected by H5N1 virus has specific characteristics namely the presence of several amino acid substitutions especially on the M1 and M2 proteins. The substitutions are similar in most of H5N1 human cases in Indonesia.

  10. Human embryo cloning prohibited in Hong Kong.

    Science.gov (United States)

    Liu, Athena

    2005-12-01

    Since the birth of Dolly (the cloned sheep) in 1997, debates have arisen on the ethical and legal questions of cloning-for-biomedical-research (more commonly termed "therapeutic cloning") and of reproductive cloning using human gametes. Hong Kong enacted the Human Reproductive Technology Ordinance (Cap 561) in 2000. Section 15(1)(e) of this Ordinance prohibits the "replacing of the nucleus of a cell of an embryo with a nucleus taken from any other cell," i.e., nucleus substitution. Section 15(1)(f) prohibits the cloning of any embryo. The scope of the latter, therefore, is arguably the widest, prohibiting all cloning techniques such as cell nucleus replacement, embryo splitting, parthenogenesis, and cloning using stem cell lines. Although the Human Reproductive Technology Ordinance is not yet fully operative, this article examines how these prohibitions may adversely impact on basic research and the vision of the Hong Kong scientific community. It concludes that in light of recent scientific developments, it is time to review if the law offers a coherent set of policies in this area.

  11. Adenovirus-based vaccines against avian-origin H5N1 influenza viruses.

    Science.gov (United States)

    He, Biao; Zheng, Bo-jian; Wang, Qian; Du, Lanying; Jiang, Shibo; Lu, Lu

    2015-02-01

    Since 1997, human infection with avian H5N1, having about 60% mortality, has posed a threat to public health. In this review, we describe the epidemiology of H5N1 transmission, advantages and disadvantages of different influenza vaccine types, and characteristics of adenovirus, finally summarizing advances in adenovirus-based H5N1 systemic and mucosal vaccines.

  12. Avian Influenza (H5N1) Susceptibility and Receptors in Dogs

    OpenAIRE

    Maas,; Tacken, M.G.J.; Ruuls-van Stalle, E.M.F.; G. Koch; Rooij, De; Stockhofe-Zurwieden, N.

    2007-01-01

    Inoculation of influenza (H5N1) into beagles resulted in virus excretion and rapid seroconversion with no disease. Binding studies that used labeled influenza (H5N1) showed virus attachment to higher and lower respiratory tract tissues. Thus, dogs that are subclinically infected with influenza (H5N1) may contribute to virus spread.

  13. Avian flu : multiple introductions of H5N1 in Nigeria

    NARCIS (Netherlands)

    Ducatez, M F; Olinger, C M; Owoade, A A; De Landtsheer, S; Ammerlaan, W; Niesters, H G M; Osterhaus, A D M E; Fouchier, R A M; Muller, C P

    2006-01-01

    As the avian influenza virus H5N1 swept from Asia across Russia to Europe, Nigeria was the first country in Africa to report the emergence of this highly pathogenic virus. Here we analyse H5N1 sequences in poultry from two different farms in Lagos state and find that three H5N1 lineages were indepen

  14. Explaining Hong Kong Students' International Achievement in Civic Learning

    Institute of Scientific and Technical Information of China (English)

    Kerry J.KENNEDY; LI Lijuan

    2016-01-01

    This study identifies predictors ofHong Kong students' civic learning.It has adopted a cross-sectional quantitative design using secondary data from the 2009 International Civics and Citizenship Education Study (ICCS 2009;Schulz et al.,2010).Multi-level analysis reveals that most of the variance in student achievement can be accounted for by school level rather than individual level factors.Student background variables are largely insignificant suggesting the resilience of many Hong Kong students.Regarding Hong Kong students' achievements in civic learning,a possible explanation is made and implications are developed for both theory and practice.

  15. Household food waste recycling in Hong Kong : issues and potential

    OpenAIRE

    Chan, Yee-man; 陳懿雯

    2014-01-01

    The food waste problem has recently been put in the spotlight in Hong Kong and around the world. Food waste is the largest part of the municipal solid waste in Hong Kong, which accounts for more than a third of all solid waste. In 2011, there was approximately 3,600 tonnes of food waste generated everyday, with two-thirds coming from households and one-third from the commercial and industrial sector. The capacities of the three strategic landfills in Hong Kong are going to be exhausted soon. ...

  16. 高致病性H5N1型禽流感%The overview of highly pathogenic H5N1 avian influenza

    Institute of Scientific and Technical Information of China (English)

    高维旭; 董芝

    2006-01-01

    目的:高致病性H5N1型禽流感在亚洲的持续爆发引起了人们对全球流感大流行的担心.截至2006年2月,已有160多人被证实感染了H5N1型禽流感,80多人已死亡.本文对H5N1型禽流感的起源,传播,预防及治疗,以及可能的流行情况进行了综述.

  17. Decision-Making in the Hong Kong Bank Stock Market

    Directory of Open Access Journals (Sweden)

    Tai-Yuen HON

    2015-12-01

    Full Text Available Abstract. This paper investigates the decision-making of small investors in the Hong Kong bank stock market.The objective of this study was to search the factors, investing characteristics, and decision-making processes that affect Hong Kong small investors who participate in bank stock market.The results suggest that we can derive the following ascending order of importance of factors:reference group, stock nature, returnsperformance and bank performance. Reference group is the least important factor and bank performance is the most important factor. We used Kendall rank correlation coefficients to measure thedifferent ranking of factorsand are therefore attempting to give advice for financial advisers approaching target customers in Hong Kong. Keywords.Investment decision, smallinvestors, bank stock markets, Hong Kong.JEL. G02, G10, G11.

  18. Gaming behavior and addiction among Hong Kong adolescents

    National Research Council Canada - National Science Library

    Wong, Irene Lai Kuen; Lam, Millicent Pui Sze

    2016-01-01

    Game playing is very popular among Hong Kong teenagers. This study aimed to investigate adolescent gaming behavior and addiction at the Internet cafe, and to explore perceived benefits and harms associated...

  19. Introduction of Eleutherodactylus planirostris (Amphibia, Anura, Eleutherodactylidae to Hong Kong

    Directory of Open Access Journals (Sweden)

    Wing Ho Lee

    2016-06-01

    Full Text Available An unidentified small frog species was first encountered in Hong Kong Special Administration Region (SAR, China, in 2000, where the local amphibian diversity is well-studied. We herein identified this unknown frog as Eleutherodactylus planirostris (greenhouse frog using DNA barcoding. We found that its distribution in Hong Kong is widespread (>18 localities, and breeding has been observed in multiple occasions. The populations in at least four localities persisted for over seven years. We discuss its potential negative impacts to terrestrial ecosystems in Hong Kong, with particular concern of its potential competition with the endemic Liuixalus romeri. We call for studies to investigate the impacts of the introduced E. planirostris on the local ecosystem. Screening for E. planirostris in exported plants from Hong Kong should be carried out.

  20. Differences between influenza virus receptors on target cells of duck and chicken and receptor specificity of the 1997 H5N1 chicken and human influenza viruses from Hong Kong.

    Science.gov (United States)

    Gambaryan, A S; Tuzikov, A B; Bovin, N V; Yamnikova, S S; Lvov, D K; Webster, R G; Matrosovich, M N

    2003-01-01

    To study whether influenza virus receptors in chickens differ from those in other species, we compared the binding of lectins and influenza viruses with known receptor specificity to cell membranes and gangliosides from epithelial tissues of ducks, chickens, and African green monkeys. We found that chicken cells contained Neu5Ac alpha(2-6)Gal-terminated receptors recognized by Sambucus nigra lectin and by human viruses. This finding explains how some recent H9N2 viruses replicate in chickens despite their human virus-like receptor specificity. Duck virus bound to gangliosides with short sugar chains that were abundant in duck intestine. Human and chicken viruses did not bind to these gangliosides and bound more strongly than duck virus to gangliosides with long sugar chains that were found in chicken intestinal and monkey lung tissues. Chicken and duck viruses also differed by their ability to recognize the structure of the third sugar moiety in Sia2-3Gal-terminated receptors. Chicken viruses preferentially bound to Neu5Ac alpha(2-3)Gal beta(1-4)GlcNAc-containing synthetic sialylglycopolymer, whereas duck viruses displayed a higher affinity for Neu5Ac alpha(2-3)Gal beta(1-3)GalNAc-containing polymer. Our data indicate that sialyloligosaccharide receptors in different avian species are not identical and provide a potential explanation for the differences between the hemagglutinin and neuraminidase proteins of duck and chicken viruses.

  1. Evaluating Hong Kong's air pollution legislation and policies

    OpenAIRE

    Wong, Ping-hei, Benny; 黃丙熙

    2014-01-01

    Air pollution is a major environmental problem that poses numerous health risks to those exposed to it. The adverse health effects are compounded in a place as dense as Hong Kong and further intensified due to its proximity to industrial and manufacturing plants across the border in Mainland China. Hong Kong has attempted to address the issue of air pollution through the enactment of legislation and policies such as the 1983 Air Pollution Control Ordinance and Air Quality Objectives, but so f...

  2. The shift green challenges of Hong Kong construction industry

    OpenAIRE

    Kwan, Shuk-wai; 關淑慧

    2013-01-01

    Recognizing that green construction industry has begun to notify recently among Hong Kong citizens; people begin to concern about the environment protection practices in daily life. The government has introduced the green building development since 1996, however, the development and policy do not mature enough as other developed countries. The Hong Kong green development is lagging behind. In the context of this research will focus on the following objectives: i) to review the current status ...

  3. Climate Responsive Buildings Concepts in Hong Kong

    DEFF Research Database (Denmark)

    Haase, M.; Amato, A.; van der Aa, A.

    2006-01-01

    energy saving installations are increasingly applied as heat pumps in combination with energy storage, balanced ventilation with heat recovery, cooling towers etc. In Hong Kong in most cases there is no integrated design process for building projects. This means that projects are developed and designed...... of the established responsive building elements have been applied. This is mainly due to lack of information, lack of incentives, high capital cost, lack of competition between suppliers, lack of guidelines and design tools, lack of practical demonstrations, lack of cooperation between designers. On the other hand......There is a global need for a more sustainable building development. About 50% of energy is used in buildings indicating that buildings provide a considerable potential for operational energy savings. Studies were conducted with the following objectives: to perform a state-of-the-art review...

  4. Virtual blood banking in Hong Kong.

    Science.gov (United States)

    Wong, K F; Kwan, Angela M Y; Wong, Michael L G; Lam, Clarence C K; Yip, S C

    2012-08-01

    OBJECTIVE. To review our experience in virtual blood banking for intra-operative transfusion in Hong Kong. DESIGN. Retrospective study. SETTING. Three major acute hospitals and a specialised centre for joint replacement surgery with installation of an Operating Theatre Blood Transaction System. PATIENTS. Patients undergoing surgery under anaesthesia and requiring intra-operative transfusion for the period from the implementation of the system in individual institutes (Queen Elizabeth Hospital: June 1997; Princess Margaret Hospital: May 2001; Queen Mary Hospital: October 2009; and Hong Kong Buddhist Hospital: December 2010) till September 2011. RESULTS. Under the system, 58 923 units of red cells were released intra-operatively for 18 264 patients (11% of the total number of blood units issued by the blood banks in these institutes during the study period). About 1% of them (613 units) entailed unmatched red cells given to 183 patients for emergency transfusions during surgery. The mean time required for the issue of the first unit of red cells was less than 1 minute. A total of 1231 units of red cells were returned unused after being released. Among them, 95 units were deemed unfit for re-issue because they had left the temperature-monitored blood storage refrigerators in the operating theatres for more than 30 minutes. There was no delay in transfusion or postponement of surgery due to problems or downtime of the Operating Theatre Blood Transaction System. CONCLUSION. Our experience has shown that our virtual blood banking system was efficient and effective, and helped ensure that the right patient received the right amount of the right blood at the right time. The system can be implemented either locally in the same hospital with a central blood bank, or in a more remote and networked site without a nearby supporting blood bank.

  5. H5N1 VLP vaccine induced protection in ferrets against lethal challenge with highly pathogenic H5N1 influenza viruses.

    Science.gov (United States)

    Mahmood, Kutubuddin; Bright, Rick A; Mytle, Nutan; Carter, Donald M; Crevar, Corey J; Achenbach, Jenna E; Heaton, Penny M; Tumpey, Terrence M; Ross, Ted M

    2008-10-03

    In this study, recombinant virus-like particles (VLPs) were evaluated as a candidate vaccine against emerging influenza viruses with pandemic potential. The VLPs are composed of the hemagglutinin (HA), neuraminidase (NA), and matrix 1 (M1) proteins of the H5N1 A/Indonesia/05/2005 (clade 2.1; [Indo/05]) virus, which were expressed using baculovirus in Spodoptera frugiperda (Sf9) cells. Ferrets received either 2 injections of the VLP vaccine at escalating doses (based on HA content), recombinant HA, or were mock vaccinated. Vaccinated ferrets were then challenged with either H5N1 Indo/05 or H5N1 A/Viet Nam 1203/2004 (VN/04) wild-type viruses. All ferrets that received the VLP vaccine survived regardless of the VLP dose or challenge strain, whereas seven of eight mock vaccinated ferrets died. The VLP vaccine induced HAI antibodies against the homologous H5N1 clade 2.1 strain, as well as heterologous strains from H5N1 clades 1, 2.2, and 2.3. The magnitude of the HAI titers correlated with VLP dose. Neutralizing antibody responses against the Indo/05 and VN/04 strains showed a similar pattern. Affinity of the anti-HA antibodies raised by the H5N1 Indo/05 VLPs had a higher association rate to the homologous clade 2.1 HA than to the clade 1 (VN/04) HA; however, once bound, antibodies had similar slow disassociation rates. These results provide support for continued development of the H5N1 VLPs as a candidate vaccine against pandemic influenza. Exploration of immunologic correlates of protection for H5N1 vaccines beyond HAI and neutralizing antibody responses is warranted.

  6. Bovine adenoviral vector-based H5N1 influenza vaccine overcomes exceptionally high levels of pre-existing immunity against human adenovirus.

    Science.gov (United States)

    Singh, Neetu; Pandey, Aseem; Jayashankar, Lakshmi; Mittal, Suresh K

    2008-05-01

    Because of the high prevalence of adenovirus (Ad) infections in humans, it is believed that pre-existing Ad-neutralizing antibodies (vector immunity) may negatively impact the immune response to vaccine antigens when delivered by human Ad (HAd) vectors. In order to evaluate whether bovine Ad subtype 3 (BAd3), a non-HAd vector, can effectively elude high levels of pre-existing vector immunity, naïve and HAd serotype 5 (HAd)-primed mice were immunized with BAd-H5HA [BAd3 vector expressing the hemagglutinin (HA) gene from H5N1 influenza virus]. Even in the presence of very high levels of HAd-specific neutralizing antibody, no significant reductions in HA-specific humoral and cell-mediated immune (CMI) responses were observed in HAd-primed mice immunized with BAd-H5HA. In naïve mice immunized with HAd-H5HA (HAd5 vector expressing H5N1 HA) and boosted with BAd-H5HA, the humoral responses elicited were significantly higher (P BAd-H5HA alone, while the CMI responses were comparable in the groups. This finding underlines the importance of a heterologous prime-boost approach for achieving an enhanced immune response. The immunization of naïve or HAd-primed mice with BAd-H5HA bestowed full protection from morbidity and mortality following a potentially lethal challenge with A/Hong Kong/483/97. These results demonstrate the importance of BAd vectors as an alternate or supplement to HAd vectors for influenza pandemic preparedness.

  7. The development of the Hong Kong Heat Index for enhancing the heat stress information service of the Hong Kong Observatory

    Science.gov (United States)

    Lee, K. L.; Chan, Y. H.; Lee, T. C.; Goggins, William B.; Chan, Emily Y. Y.

    2016-07-01

    This paper presents a study to develop a heat index, for use in hot and humid sub-tropical climate in Hong Kong. The study made use of hospitalization data and heat stress measurement data in Hong Kong from 2007 to 2011. The heat index, which is called Hong Kong Heat Index (HKHI), is calculated from the natural wet bulb temperature, the globe temperature, and the dry bulb temperature together with a set of coefficients applicable to the high humidity condition in the summer of Hong Kong. Analysis of the response of hospitalization rate to variation in HKHI and two other heat indices, namely Wet Bulb Globe Temperature (WBGT) and Net Effective Temperature (NET), revealed that HKHI performed generally better than WBGT and NET in reflecting the heat stress impact on excess hospitalization ratio in Hong Kong. Based on the study results, two reference criteria of HKHI were identified to establish a two-tier approach for the enhancement of the heat stress information service in Hong Kong.

  8. Perception of wine labels by Hong Kong Chinese consumers

    OpenAIRE

    Vicky Chi Man Tang; Anat Tchetchik; Eli Cohen

    2015-01-01

    Despite Hong Kong׳s growing wine consumption and the abundance of retail brands available there, the demanding choice task faced by its wine consumers, who are more subject to a mix of Chinese and Western cultural influences than consumers in other South Asian countries, has not been studied until now. This exploratory study aims to delve into the importance of wine label attributes for Hong Kong Chinese wine consumers, and to shed light on the ways in which their perceptions affect their cho...

  9. Perception of wine labels by Hong Kong Chinese consumers

    Directory of Open Access Journals (Sweden)

    Vicky Chi Man Tang

    2015-06-01

    Full Text Available Despite Hong Kong׳s growing wine consumption and the abundance of retail brands available there, the demanding choice task faced by its wine consumers, who are more subject to a mix of Chinese and Western cultural influences than consumers in other South Asian countries, has not been studied until now. This exploratory study aims to delve into the importance of wine label attributes for Hong Kong Chinese wine consumers, and to shed light on the ways in which their perceptions affect their choice of wine. Employing an online survey, the results suggest that Hong Kong Chinese wine consumers look for the top three most searched attributes: wine origin, grape variety, and food and wine pairing. A simple means differences test indicated that a traditional label design is favored over modern and contemporary wine labels, and that yellow is the most preferred color. However, a data-driven segmentation analysis reveals that about 95% of young Hong Kong Chinese wine consumers prefer “elegant contemporary” labels with red as the dominant color. These findings could be useful for wineries entering this market and for wine label designers who wish to better understand how Hong Kong wine consumers assess alternatives when choosing a bottle of wine.

  10. T-705 (favipiravir) activity against lethal H5N1 influenza A viruses.

    Science.gov (United States)

    Kiso, Maki; Takahashi, Kazumi; Sakai-Tagawa, Yuko; Shinya, Kyoko; Sakabe, Saori; Le, Quynh Mai; Ozawa, Makoto; Furuta, Yousuke; Kawaoka, Yoshihiro

    2010-01-12

    The neuraminidase inhibitors oseltamivir and zanamivi are used to treat H5N1 influenza. However, oseltamivir-resistant H5N1 viruses have been isolated from oseltamivir-treated patients. Moreover, reassortment between H5N1 viruses and oseltamvir-resistant human H1N1 viruses currently circulating could create oseltamivir-resistant H5N1 viruses, rendering the oseltamivir stockpile obsolete. Therefore, there is a need for unique and effective antivirals to combat H5N1 influenza viruses. The investigational drug T-705 (favipiravir; 6-fluoro-3-hydroxy-2-pyrazinecarboxamide) has antiviral activity against seasonal influenza viruses and a mouse-adapted H5N1 influenza virus derived from a benign duck virus. However, its efficacy against highly pathogenic H5N1 viruses, which are substantially more virulent, remains unclear. Here, we demonstrate that T-705 effectively protects mice from lethal infection with oseltamivir-sensitive or -resistant highly pathogenic H5N1 viruses. Furthermore, our biochemical analysis suggests that T-705 ribofuranosyl triphosphate, an active form of T-705, acts like purines or purine nucleosides in human cells and does not inhibit human DNA synthesis. We conclude that T-705 shows promise as a therapeutic agent for the treatment of highly pathogenic H5N1 influenza patients.

  11. Technology for Tomorrow---High-Tech Exhibition Held in HONG KONG

    Institute of Scientific and Technical Information of China (English)

    Fang Lin

    1997-01-01

    @@ "Technology for Tomorrow"--- High-Tech Exhibition has been held by Hong Kong Science & Technology Sector for Celebration of Return of Sovereignty Association and China Association Science & Technology on June 28 to July 4, 1997 in Hong Kong.

  12. 长沙市家禽市场环境中H5N1亚型禽流感病毒传播风险研究%Risk related to the transmission of H5N1 subtype avian influenza virus in the environment of poultry markets in Changsha, China

    Institute of Scientific and Technical Information of China (English)

    张如胜; 欧新华; 宋克云; 袁洁; 陈田木; 肖姗; 孙边成

    2012-01-01

    .7%,19/77).H5 subtype AIV positive rate was different in the tested specimens,with ranking of positive rates were sewage (50.0%,24/48),feathers (44.5%,4/9 ),birds stools ( 29.8%,14/47) and smearing samples of poultry cages (14.3%,8/56),with statistically significant differences (P<0.01).Four H5N1 HA genes TA cloning were successfully constructed and identified as Eurasian branch,similar to viruses isolated in mainland China and Hong Kong in the same group,according to genetic analysis.Sequence data of the four HA genes showed the same feature of high pathogenicity,compared to the H5N 1 AIV from mainland China of human origin.The receptor specificities were still with avian influenza origin (QSG)and the connecting peptide between HA1 and HA2 possessing the polybasic motif (RERRRKK or RERRGKK).Conclusion One of the reasons for H5N1 antibody positive rate of 25.5% among poultry markets workers was that there were large numbers of H5N 1 subtype AIV detected in the environment of poultry markets and HA genes of H5N 1 subtype AIV in the poultry markets environment carried molecular characteristics of highly pathogenic which could increase the risk for H5N1 subtype AIV transmission in the environment of poultry markets.%目的 对长沙市家禽市场职业暴露人群进行禽流感病毒(AIV)H5N1亚型抗体水平和环境AIV核酸检测,并对环境中AIV H5N1亚型的血凝素(HA)基因进行测序分析.方法 抽取长沙市1个区和1个县,各选择2个城区或乡镇家禽市场进行职业暴露人群H5N1抗体和环境AIV核酸检测.利用单放射免疫扩散溶血实验(SRH)对102份家禽市场职业暴露人员血清标本进行H5N1抗体检测,real-time PCR方法检测160份家禽市场环境标本(污水、禽类粪便、羽毛和禽类笼具表面涂抹标本)AIV核酸,对4份污水H5N1亚型AIV核酸阳性标本进行HA基因RT-PCR扩增和TA克隆测序,测序结果利用Lasergene和Mega 5.0软件进行氨基酸比对

  13. Homosubtypic and heterosubtypic antibodies against highly pathogenic avian influenza H5N1 recombinant proteins in H5N1 survivors and non-H5N1 subjects.

    Science.gov (United States)

    Noisumdaeng, Pirom; Pooruk, Phisanu; Prasertsopon, Jarunee; Assanasen, Susan; Kitphati, Rungrueng; Auewarakul, Prasert; Puthavathana, Pilaipan

    2014-04-01

    Six recombinant vaccinia viruses containing HA, NA, NP, M or NS gene insert derived from a highly pathogenic avian influenza H5N1 virus, and the recombinant vaccinia virus harboring plasmid backbone as the virus control were constructed. The recombinant proteins were characterized for their expression and subcellular locations in TK(-) cells. Antibodies to the five recombinant proteins were detected in all 13 sequential serum samples collected from four H5N1 survivors during four years of follow-up; and those directed to rVac-H5 HA and rVac-NA proteins were found in higher titers than those directed to the internal proteins as revealed by indirect immunofluorescence assay. Although all 28 non-H5N1 subjects had no neutralizing antibodies against H5N1 virus, they did have cross-reactive antibodies to those five recombinant proteins. A significant increase in cross-reactive antibody titer to rVac-H5 HA and rVac-NA was found in paired blood samples from patients infected with the 2009 pandemic virus.

  14. Ozone production and hydrocarbon reactivity in Hong Kong, Southern China

    Directory of Open Access Journals (Sweden)

    J. Zhang

    2007-01-01

    Full Text Available Data obtained in Hong Kong during the Hong Kong and the Pearl River Delta (PRD Pilot Air Monitoring Study in autumn 2002 are analyzed to unravel the relationship between ground-level ozone (O3, pollution precursors, and cross-border transport. Ten ozone episodes, during which the hourly O3 concentration exceeded 100 ppbv in 9 cases and 90 ppbv in one case, are subject to detailed analysis, including one case with hourly O3 of 203 ppbv, which is the highest concentration on record to date in Hong Kong. Combined with high-resolution back trajectories, dCO/dNOy (the ratio of enhancement of CO concentration above background to that of NOy is used to define whether O3 is locally or regionally produced. Five out of the ten Hong Kong O3-episodes studied show a "pollution signature" that is indicative of impact from Guangdong Province. Examination of speciated volatile organic compounds (VOCs shows that the reactivity of VOCs is dominated by anthropogenic VOCs, of which the reactive aromatics dominate, in particular xylenes and toluene. Calculations using a photochemical box model indicate that between 50–100% of the O3 increase observed in Hong Kong during the O3 episodes can be explained by photochemical generation within the Hong Kong area, provided that nitrous acid (HONO is present at the concentrations derived from this study. An Observation-Based Model (OBM is used to calculate the sensitivity of the O3 production to changes in the concentrations of the precursor compounds. Generally the production of O3 throughout much of the Hong Kong area is limited by VOCs, while high nitric oxide (NO concentrations suppress O3 concentration.

  15. Evolving towards professionalism in emergency nursing in Hong Kong.

    Science.gov (United States)

    Wong, Eliza Mi-Ling; Lau, Ping Fat

    2008-01-01

    This paper aims to share with the readers about the experience of emergency nursing development and related roles in Hong Kong. The roles of emergency nurses are evolving and triggered by three major historical milestones. The three milestones consist of: (1) Transition of nursing education from hospital training to nursing degree program at universities in 1990; (2) The re-evolution after the establishment of Hospital Authority in 1993; (3) Hong Kong's return to China in 1997. These milestones have contributed immensely to the development of quality nursing education, nursing professionalism with emphasis on specialty knowledge and skill training in Accident and Emergency departments (AED) in Hong Kong. Since 1991, the emergency nursing role has been expanded and extended. Wound management remains one of the major extending roles for emergency nurses, who confine themselves to manage simple wounds. Nurse initiated tetanus immunization, intravenous access; investigations such as electrocardiogram, blood glucose, and urinalysis are well implemented in all AEDs under the governance of guidelines and protocols. Initial triage analgesic for the minor musculoskeletal injury and fever are also part of the triage care in some AEDs in Hong Kong now. To meet the demand and challenge, innovative role development such as lecturer practitioners and emergency nurse practitioners have been piloted and implemented recently. Besides the normal duty, emergency nurses also participate in the work outside the hospitals such as involvement in emergency medical teams to assist in various rescue missions or volunteer for Flight Nursing (Government Flying Services). However, the nursing shortage is another common problem faced by the Hong Kong health care body. With the help of advanced technology, better pre-graduate and specialty-training programs, Hong Kong health care strives to achieve the highest standards of quality care. Emergency nursing role development in Hong Kong is evolving

  16. Influenza A H5N1 immigration is filtered out at some international borders.

    Directory of Open Access Journals (Sweden)

    Robert G Wallace

    Full Text Available BACKGROUND: Geographic spread of highly pathogenic influenza A H5N1, the bird flu strain, appears a necessary condition for accelerating the evolution of a related human-to-human infection. As H5N1 spreads the virus diversifies in response to the variety of socioecological environments encountered, increasing the chance a human infection emerges. Genetic phylogenies have for the most part provided only qualitative evidence that localities differ in H5N1 diversity. For the first time H5N1 variation is quantified across geographic space. METHODOLOGY AND PRINCIPAL FINDINGS: We constructed a statistical phylogeography of 481 H5N1 hemagglutinin genetic sequences from samples collected across 28 Eurasian and African localities through 2006. The MigraPhyla protocol showed southern China was a source of multiple H5N1 strains. Nested clade analysis indicated H5N1 was widely dispersed across southern China by both limited dispersal and long distance colonization. The UniFrac metric, a measure of shared phylogenetic history, grouped H5N1 from Indonesia, Japan, Thailand and Vietnam with those from southeastern Chinese provinces engaged in intensive international trade. Finally, H5N1's accumulative phylogenetic diversity was greatest in southern China and declined beyond. The gradient was interrupted by areas of greater and lesser phylogenetic dispersion, indicating H5N1 migration was restricted at some geopolitical borders. Thailand and Vietnam, just south of China, showed significant phylogenetic clustering, suggesting newly invasive H5N1 strains have been repeatedly filtered out at their northern borders even as both countries suffered recurring outbreaks of endemic strains. In contrast, Japan, while successful in controlling outbreaks, has been subjected to multiple introductions of the virus. CONCLUSIONS: The analysis demonstrates phylogenies can provide local health officials with more than hypotheses about relatedness. Pathogen dispersal, the

  17. Protective efficacy of an H5N1 DNA vaccine against challenge with a lethal H5N1 virus in quail.

    Science.gov (United States)

    Li, Junping; Jiang, Yongping; Zhao, Shuangcheng; Chang, Xiaofei; Liu, Jinxiong; Zeng, Xianying; Li, Yanbing; Chen, Hualan

    2012-12-01

    Some H5N1 avian influenza viruses (AIVs) are lethal to quail; however, the use of inactivated vaccines in these birds is largely restricted because of side effects caused by oil adjuvants. Here we evaluated the protective efficacy of a DNA vaccine against lethal challenge with H5N1 highly pathogenic avian influenza virus (HPAIV) in quail. Groups of ten 3-wk-old quail were intramuscularly inoculated three times at 3-wk intervals with 10, 15, 30, or 60 microg, respectively, of plasmid pCAGGoptiHA, which expresses a codon-optimized hemagglutinin gene of the H5N1 virus A/goose/Guangdong/1/96 (GS/GD/96). The control group was inoculated with phosphate-buffered saline. Hemagglutination-inhibition (HI) antibodies were monitored every week after the primary vaccination. The quail were challenged intranasally with 10(5) EID50 of heterologous HPAIV A/duck/Fujian/31/2007 (DK/ FJ/31) (H5N1) 2 wk after the third inoculation. Oropharyngeal and cloacal swab specimens were collected 3, 5, and 7 days after inoculation, and quail were observed daily for disease signs and death for 2 wk. The quail showed no side effects after the plasmid inoculation, and HI antibodies were detectable 1 wk after the second vaccination in all groups and increased sharply after the third inoculation. All quail in the PBS-inoculated group and 20% of the birds in the 10 microg plasmid-inoculated group died after the lethal H5N1 virus challenge; however, birds in the 15, 30, and 60 jg plasmid-inoculated groups were completely protected. These results indicate that this DNA vaccine holds promise for use in quail to protect against H5N1 AIV.

  18. 2006 Cooperation Forum of the Chinese Mainland,Taiwan and Hong Kong Foundry Industry

    Institute of Scientific and Technical Information of China (English)

    TIAN Shi-jiang; GE Chen-guang

    2006-01-01

    @@ The 2006 Cooperation Forum of the Chinese Mainland,Taiwan and Hong Kong foundry industry sponsored by China Foundry Association and jointly sponsored by Taiwan Casting Industry Association, Hong Kong Foundry Association and Hong Kong Die Casting Association was held in Beijing Zhongyuan Hotel on April 17, 2006.

  19. From Capitalism to Socialism? Hong Kong Education within a Transitional Society.

    Science.gov (United States)

    Postiglione, Gerard A.

    1991-01-01

    Examines implications for educational policy formation of Hong Kong's 1997 return to China. Discusses the economic interdependence of Hong Kong and China; the potential for educational policy to reconcile or heighten the contradictions among capitalism, socialism, and patriotism; and the crisis of cultural identity among Hong Kong youth. (SV)

  20. Effectiveness of cognitive training for Chinese elderly in Hong Kong

    Directory of Open Access Journals (Sweden)

    Kwok T

    2013-02-01

    Full Text Available Timothy Kwok,1,2 Anita Wong,3 Grace Chan,4 YY Shiu,3 Ko-Chuen Lam,2 Daniel Young,2 Daniel WH Ho,2 Florence Ho21Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, People's Republic of China; 2Jockey Club Centre for Positive Ageing, Shatin, Hong Kong, People's Republic of China; 3The Hong Kong Chinese Women's Club Madam Wong Chan Sook Ying Memorial Care and Attention Home for the Aged, Hong Kong, People's Republic of China; 4The Hong Kong Council of Social Service, Hong Kong, People's Republic of ChinaAbstract: In Hong Kong, the evidence for cognitive-training programs in fighting against memory complaints is lacking. This study aimed to evaluate the effectiveness of the Active Mind cognitive-training program in improving the cognitive function and quality of life (QoL for local community-dwelling Chinese older adults. A total of 200 subjects were recruited from 20 different district elderly community centers (DECCs. Centers were randomly assigned into either the intervention group or control group. The intervention group underwent eight 1-hour sessions of cognitive training, while the control group were included in the usual group activities provided by the DECCs. Standardized neuropsychological tests (the Chinese version of Mattis Dementia Rating Scale [CDRS] and the Cantonese version of the Mini-Mental State Examination and the QoL questionnaire SF12 were used to assess participants' cognitive function and QoL before and after the trial. A total of 176 subjects completed the study. The intervention group showed greater improvement in the cognitive function measured by total CDRS score (treatment: 12.24 ± 11.57 vs control: 4.37 ± 7.99; P < 0.001 and QoL measured by total SF12 score (treatment: 7.82 ± 13.19 vs control: 3.18 ± 11.61; P = 0.014. Subjects with lower education level were associated with better cognitive response to the cognitive-training program. The current findings indicated that the Active

  1. Subclinical avian influenza A(H5N1) virus infection in human, Vietnam.

    Science.gov (United States)

    Le, Mai Quynh; Horby, Peter; Fox, Annette; Nguyen, Hien Tran; Le Nguyen, Hang Khanh; Hoang, Phuong Mai Vu; Nguyen, Khanh Cong; de Jong, Menno D; Jeeninga, Rienk E; Rogier van Doorn, H; Farrar, Jeremy; Wertheim, Heiman F L

    2013-10-01

    Laboratory-confirmed cases of subclinical infection with avian influenza A(H5N1) virus in humans are rare, and the true number of these cases is unknown. We describe the identification of a laboratory-confirmed subclinical case in a woman during an influenza A(H5N1) contact investigation in northern Vietnam.

  2. An RNA conformational shift in recent H5N1 influenza A viruses

    NARCIS (Netherlands)

    Gultyaev, A.P.; Heus, H.A.; Olsthoorn, R.C.

    2007-01-01

    Recent outbreaks of avian influenza are being caused by unusually virulent H5N1 strains. It is unknown what makes these recent H5N1 strains more aggressive than previously circulating strains. Here, we have compared more than 3000 RNA sequences of segment 8 of type A influenza viruses and found a un

  3. Genetic versus antigenic differences among highly pathogenic H5N1 avian influenza A viruses

    NARCIS (Netherlands)

    Peeters, Ben; Reemers, Sylvia; Dortmans, Jos; Vries, de Erik; Jong, de Mart; Zande, van de Saskia; Rottier, Peter J.M.; Haan, de Cornelis A.M.

    2017-01-01

    Highly pathogenic H5N1 avian influenza A viruses display a remarkable genetic and antigenic diversity. We examined to what extent genetic distances between several H5N1 viruses from different clades correlate with antigenic differences and vaccine performance. H5-specific antisera were generated, an

  4. Highlight the significance of genetic evolution of H5N1 avian flu

    Institute of Scientific and Technical Information of China (English)

    LU Jia-hai; ZHANG Ding-mei; WANG Guo-ling

    2006-01-01

    @@ Agrowing concern has focused on the recent identification of influenza A H5N1 virus in Asia.Previously thought to infect only wild birds and poultry, H5N1 has now infected humans, cats, pigs,and other mammals in an ongoing outbreak, often with fatal results. According to a report from the World Health Organization (WHO), 217 human H5N1 cases have been confirmed and 123 of them have been fatal as of May 19, 2006.1 But many questions remain unanswered, for example how the H5N1 virus could cross species barriers and acquire the ability to infect humans; when and how the H5N1 virus will transmit effectively between humans and cause an influenza pandemic; and what are the determinants of its high virulence. This article summarizes research progress on the origin of H5N1 virus, factors determining pathogenicity, the contribution of genetic evolution to H5N1 species barrier traversal, human-to-human transmission, and problems in prevention and treatment of H5N1 avian influenza virus.

  5. Virulence of H5N1 Influenza Virus in Cattle Egrets (Bubulcus Ibis)

    DEFF Research Database (Denmark)

    Phuong, Do Quy; Dung, Nguyen Tien; Jørgensen, Poul Henrik

    2011-01-01

    for insect control in households. In this study, six Cattle Egrets were experimentally infected intranasally with highly pathogenic avian influenza (AI) A/duck/Vietnam/40D/04 (H5N1) to investigate a possible epidemiologic role for Cattle Egrets in outbreaks of H5N1 AI in Vietnam. The Cattle Egrets were...

  6. Genetic characterization of 2008 reassortant influenza A virus (H5N1, Thailand

    Directory of Open Access Journals (Sweden)

    Wongphatcharachai Manoosak

    2010-09-01

    Full Text Available Abstract In January and November 2008, outbreaks of avian influenza have been reported in 4 provinces of Thailand. Eight Influenza A H5N1 viruses were recovered from these 2008 AI outbreaks and comprehensively characterized and analyzed for nucleotide identity, genetic relatedness, virulence determinants, and possible sites of reassortment. The results show that the 2008 H5N1 viruses displayed genetic drift characteristics (less than 3% genetic differences, as commonly found in influenza A viruses. Based on phylogenetic analysis, clade 1 viruses in Thailand were divided into 3 distinct branches (subclades 1, 1.1 and 1.2. Six out of 8 H5N1 isolates have been identified as reassorted H5N1 viruses, while other isolates belong to an original H5N1 clade. These viruses have undergone inter-lineage reassortment between subclades 1.1 and 1.2 and thus represent new reassorted 2008 H5N1 viruses. The reassorted viruses have acquired gene segments from H5N1, subclade 1.1 (PA, HA, NP and M and subclade 1.2 (PB2, PB1, NA and NS in Thailand. Bootscan analysis of concatenated whole genome sequences of the 2008 H5N1 viruses supported the reassortment sites between subclade 1.1 and 1.2 viruses. Based on estimating of the time of the most recent common ancestors of the 2008 H5N1 viruses, the potential point of genetic reassortment of the viruses could be traced back to 2006. Genetic analysis of the 2008 H5N1 viruses has shown that most virulence determinants in all 8 genes of the viruses have remained unchanged. In summary, two predominant H5N1 lineages were circulating in 2008. The original CUK2-like lineage mainly circulated in central Thailand and the reassorted lineage (subclades 1.1 and 1.2 predominantly circulated in lower-north Thailand. To prevent new reassortment, emphasis should be put on prevention of H5N1 viruses circulating in high risk areas. In addition, surveillance and whole genome sequencing of H5N1 viruses should be routinely performed for

  7. Resurgence of cholera in Hong Kong.

    Science.gov (United States)

    Lee, S H; Lai, S T; Lai, J Y; Leung, N K

    1996-08-01

    Cholera is one of the three diseases subject to the International Health Regulations. After a period of over 30 years, the seventh pandemic of cholera, which started in South East Asia in 1961, still shows no sign of a decline. On the contrary, it has increased its severity and invaded many other countries in Africa and Latin America. In the last two years, there has been a recrudescence of the disease in South East Asia and Western Pacific Regions. The discovery of a new strain of Vibrio cholerae 0139 in these regions is causing concern in view of its potential to cause major epidemics and higher mortality. Hong Kong had two intensive outbreaks of cholera in the last two years. The cause of these outbreaks was not clear, but adverse environmental conditions and increasing pollution of coastal waters have been implicated. The spread of cholera knows no geographical boundaries. There is a need for intensified efforts among health authorities in the affected areas to prevent the international spread of the disease.

  8. Immunogenicity and protective efficacy of a live attenuated H5N1 vaccine in nonhuman primates.

    Directory of Open Access Journals (Sweden)

    Shufang Fan

    2009-05-01

    Full Text Available The continued spread of highly pathogenic H5N1 influenza viruses among poultry and wild birds, together with the emergence of drug-resistant variants and the possibility of human-to-human transmission, has spurred attempts to develop an effective vaccine. Inactivated subvirion or whole-virion H5N1 vaccines have shown promising immunogenicity in clinical trials, but their ability to elicit protective immunity in unprimed human populations remains unknown. A cold-adapted, live attenuated vaccine with the hemagglutinin (HA and neuraminidase (NA genes of an H5N1 virus A/VN/1203/2004 (clade 1 was protective against the pulmonary replication of homologous and heterologous wild-type H5N1 viruses in mice and ferrets. In this study, we used reverse genetics to produce a cold-adapted, live attenuated H5N1 vaccine (AH/AAca that contains HA and NA genes from a recent H5N1 isolate, A/Anhui/2/05 virus (AH/05 (clade 2.3, and the backbone of the cold-adapted influenza H2N2 A/AnnArbor/6/60 virus (AAca. AH/AAca was attenuated in chickens, mice, and monkeys, and it induced robust neutralizing antibody responses as well as HA-specific CD4+ T cell immune responses in rhesus macaques immunized twice intranasally. Importantly, the vaccinated macaques were fully protected from challenge with either the homologous AH/05 virus or a heterologous H5N1 virus, A/bar-headed goose/Qinghai/3/05 (BHG/05; clade 2.2. These results demonstrate for the first time that a cold-adapted H5N1 vaccine can elicit protective immunity against highly pathogenic H5N1 virus infection in a nonhuman primate model and provide a compelling argument for further testing of double immunization with live attenuated H5N1 vaccines in human trials.

  9. Lemna (duckweed) expressed hemagglutinin from avian influenza H5N1 protects chickens against H5N1 high pathogenicity avian influenza virus challenge

    Science.gov (United States)

    In the last two decades, transgenic plants have been explored as safe and cost effective alternative expression platforms for producing recombinant proteins. In this study, a synthetic hemagglutinin (HA) gene from the high pathogenicity avian influenza (HPAI) virus A/chicken/Indonesia/7/2003 (H5N1)...

  10. Developmental issues of university students in Hong Kong.

    Science.gov (United States)

    Shek, Daniel T L; Cheung, Boris P M

    2013-01-01

    Four domains of developmental issues of university students in Hong Kong are examined in this paper. First, behavioral and lifestyle problems of university students are identified, including alcohol consumption, Internet addiction, cyber-pornography, irregular sleep patterns, and interpersonal violence. Second, the mental health problems of university students, including suicidal ideation, depression and anxiety problems, are outlined. Third, issues on self-determination (including establishment of personal goals), self-confidence, and materialism of the students are reviewed. Fourth, issues related to students' connection to the society, including egocentrism and civic engagement, are discussed. The views of employers about university graduates in Hong Kong are also examined. With the emergence of developmental issues among Hong Kong university students, it is argued that promoting the psychosocial competencies of university students via positive youth development programs is an important strategy in addressing such issues.

  11. Remembering Student Activities in Hong Kong During the War of Resistance Against Japan (Ⅰ)

    Institute of Scientific and Technical Information of China (English)

    1997-01-01

    COMPATRIOTS in Hong Kong share a revolutionary tradition. Early in 1922 and 1925, the Seamen’s Strike and Guangdong-Hong Kong Strike were taking place in Hong Kong, shocking the country and the world. During the one-year-long Guangdong-Hong Kong Strike, many family members of workers also fought. Late in 1936, influenced by the upsurge of resistance against Japanese aggression in the country, people in Hong Kong rose up to help save the nation. Save-the-nation associations of women, students and literary and art circles went up one after another. When the news that Fu

  12. H5N1 病毒感染及其防治现状

    Institute of Scientific and Technical Information of China (English)

    孙丽萍; 马静

    2007-01-01

    @@ 高致病性禽流感病毒-H5N1(Avian Influenza A Virus-H5N1)不仅影响了家禽,而且已经跨越种属障碍,感染人类,并导致许多病例病死.H5N1 病毒感染的流行尚未得到有效控制,还在呈范围不断扩大、感染动物种类增加的态势.本文综合有关文献,对人 H5N1 病毒感染的一些特征、临床病例处置以及 H5N1 病毒研究进展[1],以及人 H5N1 病毒感染防治措施进行了梳理,旨在探讨加强人 H5N1 病毒感染的预防与控制.

  13. Angiotensin-converting enzyme 2 protects from lethal avian influenza A H5N1 infections.

    Science.gov (United States)

    Zou, Zhen; Yan, Yiwu; Shu, Yuelong; Gao, Rongbao; Sun, Yang; Li, Xiao; Ju, Xiangwu; Liang, Zhu; Liu, Qiang; Zhao, Yan; Guo, Feng; Bai, Tian; Han, Zongsheng; Zhu, Jindong; Zhou, Huandi; Huang, Fengming; Li, Chang; Lu, Huijun; Li, Ning; Li, Dangsheng; Jin, Ningyi; Penninger, Josef M; Jiang, Chengyu

    2014-05-06

    The potential for avian influenza H5N1 outbreaks has increased in recent years. Thus, it is paramount to develop novel strategies to alleviate death rates. Here we show that avian influenza A H5N1-infected patients exhibit markedly increased serum levels of angiotensin II. High serum levels of angiotensin II appear to be linked to the severity and lethality of infection, at least in some patients. In experimental mouse models, infection with highly pathogenic avian influenza A H5N1 virus results in downregulation of angiotensin-converting enzyme 2 (ACE2) expression in the lung and increased serum angiotensin II levels. Genetic inactivation of ACE2 causes severe lung injury in H5N1-challenged mice, confirming a role of ACE2 in H5N1-induced lung pathologies. Administration of recombinant human ACE2 ameliorates avian influenza H5N1 virus-induced lung injury in mice. Our data link H5N1 virus-induced acute lung failure to ACE2 and provide a potential treatment strategy to address future flu pandemics.

  14. Endothelial cell tropism is a determinant of H5N1 pathogenesis in mammalian species.

    Directory of Open Access Journals (Sweden)

    Smanla Tundup

    2017-03-01

    Full Text Available The cellular and molecular mechanisms underpinning the unusually high virulence of highly pathogenic avian influenza H5N1 viruses in mammalian species remains unknown. Here, we investigated if the cell tropism of H5N1 virus is a determinant of enhanced virulence in mammalian species. We engineered H5N1 viruses with restricted cell tropism through the exploitation of cell type-specific microRNA expression by incorporating microRNA target sites into the viral genome. Restriction of H5N1 replication in endothelial cells via miR-126 ameliorated disease symptoms, prevented systemic viral spread and limited mortality, despite showing similar levels of peak viral replication in the lungs as compared to control virus-infected mice. Similarly, restriction of H5N1 replication in endothelial cells resulted in ameliorated disease symptoms and decreased viral spread in ferrets. Our studies demonstrate that H5N1 infection of endothelial cells results in excessive production of cytokines and reduces endothelial barrier integrity in the lungs, which culminates in vascular leakage and viral pneumonia. Importantly, our studies suggest a need for a combinational therapy that targets viral components, suppresses host immune responses, and improves endothelial barrier integrity for the treatment of highly pathogenic H5N1 virus infections.

  15. Spatio-temporal dynamics of global H5N1 outbreaks match bird migration patterns.

    Science.gov (United States)

    Si, Yali; Skidmore, Andrew K; Wang, Tiejun; de Boer, Willem F; Debba, Pravesh; Toxopeus, Albert G; Li, Lin; Prins, Herbert H T

    2009-11-01

    The global spread of highly pathogenic avian influenza H5N1 in poultry, wild birds and humans, poses a significant pandemic threat and a serious public health risk. An efficient surveillance and disease control system relies on the understanding of the dispersion patterns and spreading mechanisms of the virus. A space-time cluster analysis of H5N1 outbreaks was used to identify spatio-temporal patterns at a global scale and over an extended period of time. Potential mechanisms explaining the spread of the H5N1 virus, and the role of wild birds, were analyzed. Between December 2003 and December 2006, three global epidemic phases of H5N1 influenza were identified. These H5N1 outbreaks showed a clear seasonal pattern, with a high density of outbreaks in winter and early spring (i.e., October to March). In phase I and II only the East Asia Australian flyway was affected. During phase III, the H5N1 viruses started to appear in four other flyways: the Central Asian flyway, the Black Sea Mediterranean flyway, the East Atlantic flyway and the East Africa West Asian flyway. Six disease cluster patterns along these flyways were found to be associated with the seasonal migration of wild birds. The spread of the H5N1 virus, as demonstrated by the space-time clusters, was associated with the patterns of migration of wild birds. Wild birds may therefore play an important role in the spread of H5N1 over long distances. Disease clusters were also detected at sites where wild birds are known to overwinter and at times when migratory birds were present. This leads to the suggestion that wild birds may also be involved in spreading the H5N1 virus over short distances.

  16. Spatio-temporal dynamics of global H5N1 outbreaks match bird migration patterns

    Directory of Open Access Journals (Sweden)

    Yali Si

    2009-11-01

    Full Text Available The global spread of highly pathogenic avian influenza H5N1 in poultry, wild birds and humans, poses a significant pandemic threat and a serious public health risk. An efficient surveillance and disease control system relies on the understanding of the dispersion patterns and spreading mechanisms of the virus. A space-time cluster analysis of H5N1 outbreaks was used to identify spatio-temporal patterns at a global scale and over an extended period of time. Potential mechanisms explaining the spread of the H5N1 virus, and the role of wild birds, were analyzed. Between December 2003 and December 2006, three global epidemic phases of H5N1 influenza were identified. These H5N1 outbreaks showed a clear seasonal pattern, with a high density of outbreaks in winter and early spring (i.e., October to March. In phase I and II only the East Asia Australian flyway was affected. During phase III, the H5N1 viruses started to appear in four other flyways: the Central Asian flyway, the Black Sea Mediterranean flyway, the East Atlantic flyway and the East Africa West Asian flyway. Six disease cluster patterns along these flyways were found to be associated with the seasonal migration of wild birds. The spread of the H5N1 virus, as demonstrated by the space-time clusters, was associated with the patterns of migration of wild birds. Wild birds may therefore play an important role in the spread of H5N1 over long distances. Disease clusters were also detected at sites where wild birds are known to overwinter and at times when migratory birds were present. This leads to the suggestion that wild birds may also be involved in spreading the H5N1 virus over short distances.

  17. Internet Addiction Phenomenon in Early Adolescents in Hong Kong

    OpenAIRE

    Daniel T. L. Shek; Lu Yu

    2012-01-01

    The present study investigated the prevalence and demographic correlates of Internet addiction in Hong Kong adolescents as well as the change in related behavior at two time points over a one-year interval. Two waves of data were collected from a large sample of students (Wave 1: 3,328 students, age = 12.59 ± 0.74 years; Wave 2: 3,580 students, age = 13.50 ± 0.75 years) at 28 secondary schools in Hong Kong. Comparable to findings at Wave 1 (26.4%), 26.7% of the participants met the criterion ...

  18. Internet Open Exchange Point Set Up in Hong Kong

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    @@ Since November 23, 2004, the Beijing-Hong Kong section of the "China-US-Russia Global Ring Network for Advanced Applications Development (GLORIAD)" has been upgraded to 2.5G. And on the same day, the Chinese Academy of Sciences formally announced a plan to establish the next generation light wave "Hong Kong Internet Open Exchange Point - HK Light". This is the first Open Exchange Point in Asia and will serve as a venue where high-speed broadband Internet networks from Japan,South Korea and Taiwan Province of China will interconnect.

  19. A Brief Overview of Adolescent Developmental Problems in Hong Kong

    Directory of Open Access Journals (Sweden)

    Daniel T. L. Shek

    2011-01-01

    Full Text Available Several adolescent developmental problems in Hong Kong are briefly reviewed in this paper. First, rising adolescent substance abuse trends are described. Second, Internet use problems and Internet addiction among young people are examined. Third, worrying trends in adolescent sexuality are identified. Fourth, phenomena on bullying among young people are reviewed. Finally, phenomena related to adolescent materialistic orientation are focused upon. With reference to these adolescent developmental problems, possible solutions are briefly discussed particularly with reference to the ecological perspective. It is argued that the related scientific literature provides useful pointers for designing the curriculum in the extension phase of the Project P.A.T.H.S. in Hong Kong.

  20. Impact Evaluation of Low Flow Showerheads for Hong Kong Residents

    OpenAIRE

    Ling-tim Wong; Kwok-wai Mui; Yang Zhou

    2016-01-01

    The voluntary Water Efficiency Labelling Scheme (WELS) on showers for bathing in Hong Kong is a water conservation initiative of the Hong Kong Special Administrative Region (HKSAR) Government. As shower water consumption has been identified as a potential area for carbon emissions reductions, this study examines, from a five-month measurement survey of the showering practices of 37 local residents, a range of showerheads with resistance factors k = 0.54–4.05 kPa·min2·L−2 with showering attrib...

  1. Marine biofouling in Hong Kong:a review

    Institute of Scientific and Technical Information of China (English)

    Zongguo Huang

    2003-01-01

    From 1980 to 1998, biofouling communities in Hong Kong waters, the Zhujiang RiverEstuary and the Mirs Bay were studied and a total of 610 samples. The samples were collected from ves-sels, buoys, piers and cages. Totally, 340 species (see Appendix Ⅰ ) have been recorded and identified,six of which are new. At the same time, research on the biology of the cirripede, bryozoan, polychaeteand mollusc communities were also conducted. Twenty-three related papers have been published. Thisreview summarizes works in Hong Kong over past twenty years, and some unpublished data are also re-ported.

  2. The changing nature of avian influenza A virus (H5N1).

    Science.gov (United States)

    Watanabe, Yohei; Ibrahim, Madiha S; Suzuki, Yasuo; Ikuta, Kazuyoshi

    2012-01-01

    Highly pathogenic avian influenza A virus subtype H5N1 has been endemic in some bird species since its emergence in 1996 and its ecology, genetics and antigenic properties have continued to evolve. This has allowed diverse virus strains to emerge in endemic areas with altered receptor specificity, including a new H5 sublineage with enhanced binding affinity to the human-type receptor. The pandemic potential of H5N1 viruses is alarming and may be increasing. We review here the complex dynamics and changing nature of the H5N1 virus that may contribute to the emergence of pandemic strains.

  3. An Overview of the Highly Pathogenic H5N1 Influenza Virus

    Institute of Scientific and Technical Information of China (English)

    Jingchuan Yin; Shi Liu; Ying Zhu

    2013-01-01

    Since the first human case of H5N1 avian influenza virus infection was reported in 1997,this highly pathogenic virus has infected hundreds of people around the world and resulted in many deaths.The ability of H5N1 to cross species boundaries,and the presence of polymorphisms that enhance virulence,present challenges to developing clear strategies to prevent the pandemic spread of this highly pathogenic avian influenza (HPAI) virus.This review summarizes the current understanding of,and recent research on,the avian influenza H5N1 virus,including transmission,virulence,pathogenesis,clinical characteristics,treatment and prevention.

  4. Catalogue and Bibliography of the Hong Kong Carabidae Latreille, 1802 (Coleoptera: Adephaga), with notes on the historic boundaries of Hong Kong as related to zoological collections.

    Science.gov (United States)

    Aston, Paul

    2016-06-09

    A complete list of Carabidae species historically collected in Hong Kong combined with more recent records and notes on their biology is given. Notes on the historic boundaries of Hong Kong through the colonial period are given, as this is an important element relating to our understanding of the origins of historic zoological collections made in the region. Likewise a list of collectors in Hong Kong up to the outbreak of hostilities in the Second World War is given. A full bibliography of Hong Kong Carabidae is included.

  5. Domestic pigs have low susceptibility to H5N1 highly pathogenic avian influenza viruses.

    Directory of Open Access Journals (Sweden)

    Aleksandr S Lipatov

    2008-07-01

    Full Text Available Genetic reassortment of H5N1 highly pathogenic avian influenza viruses (HPAI with currently circulating human influenza A strains is one possibility that could lead to efficient human-to-human transmissibility. Domestic pigs which are susceptible to infection with both human and avian influenza A viruses are one of the natural hosts where such reassortment events could occur. Virological, histological and serological features of H5N1 virus infection in pigs were characterized in this study. Two- to three-week-old domestic piglets were intranasally inoculated with 10(6 EID(50 of A/Vietnam/1203/04 (VN/04, A/chicken/Indonesia/7/03 (Ck/Indo/03, A/Whooper swan/Mongolia/244/05 (WS/Mong/05, and A/Muscovy duck/Vietnam/ 209/05 (MDk/VN/05 viruses. Swine H3N2 and H1N1 viruses were studied as a positive control for swine influenza virus infection. The pathogenicity of the H5N1 HPAI viruses was also characterized in mouse and ferret animal models. Intranasal inoculation of pigs with H5N1 viruses or consumption of infected chicken meat did not result in severe disease. Mild weight loss was seen in pigs inoculated with WS/Mong/05, Ck/Indo/03 H5N1 and H1N1 swine influenza viruses. WS/Mong/05, Ck/Indo/03 and VN/04 viruses were detected in nasal swabs of inoculated pigs mainly on days 1 and 3. Titers of H5N1 viruses in nasal swabs were remarkably lower compared with those of swine influenza viruses. Replication of all four H5N1 viruses in pigs was restricted to the respiratory tract, mainly to the lungs. Titers of H5N1 viruses in the lungs were lower than those of swine viruses. WS/Mong/05 virus was isolated from trachea and tonsils, and MDk/VN/05 virus was isolated from nasal turbinate of infected pigs. Histological examination revealed mild to moderate bronchiolitis and multifocal alveolitis in the lungs of pigs infected with H5N1 viruses, while infection with swine influenza viruses resulted in severe tracheobronchitis and bronchointerstitial pneumonia. Pigs

  6. Using knowledge fusion to analyze avian influenza H5N1 in East and Southeast Asia.

    Directory of Open Access Journals (Sweden)

    Erjia Ge

    Full Text Available Highly pathogenic avian influenza (HPAI H5N1, a disease associated with high rates of mortality in infected human populations, poses a serious threat to public health in many parts of the world. This article reports findings from a study aimed at improving our understanding of the spatial pattern of the highly pathogenic avian influenza, H5N1, risk in East-Southeast Asia where the disease is both persistent and devastating. Though many disciplines have made important contributions to our understanding of H5N1, it remains a challenge to integrate knowledge from different disciplines. This study applies genetic analysis that identifies the evolution of the H5N1 virus in space and time, epidemiological analysis that determines socio-ecological factors associated with H5N1 occurrence, and statistical analysis that identifies outbreak clusters, and then applies a methodology to formally integrate the findings of the three sets of methodologies. The present study is novel in two respects. First it makes the initiative attempt to use genetic sequences and space-time data to create a space-time phylogenetic tree to estimate and map the virus' ability to spread. Second, by integrating the results we are able to generate insights into the space-time occurrence and spread of H5N1 that we believe have a higher level of corroboration than is possible when analysis is based on only one methodology. Our research identifies links between the occurrence of H5N1 by area and a set of socio-ecological factors including altitude, population density, poultry density, and the shortest path distances to inland water, coastlines, migrating routes, railways, and roads. This study seeks to lay a solid foundation for the interdisciplinary study of this and other influenza outbreaks. It will provide substantive information for containing H5N1 outbreaks.

  7. Genetic drift evolution under vaccination pressure among H5N1 Egyptian isolates

    OpenAIRE

    Afifi Manal A; Abdel-Moneim Ahmed S; El-Kady Magdy F

    2011-01-01

    Background The highly pathogenic H5N1 is a major avian pathogen that intensively affects the poultry industry in Egypt even in spite of the adoption of vaccination strategy. Antigenic drift is among the strategies the influenza virus uses to escape the immune system that might develop due to the pressure of extensive vaccination. H5N1 mutates in an intensified manner and is considered a potential candidate for the possible next pandemic with all the catastrophic consequences such an eventual...

  8. H5N1 chicken influenza viruses display a high binding affinity for Neu5Acalpha2-3Galbeta1-4(6-HSO3)GlcNAc-containing receptors.

    Science.gov (United States)

    Gambaryan, A S; Tuzikov, A B; Pazynina, G V; Webster, R G; Matrosovich, M N; Bovin, N V

    2004-09-01

    To characterize differences in the receptor-binding specificity of H5N1 chicken viruses and viruses of aquatic birds, we used a panel of synthetic polyacrylamide (PAA)-based sialylglycopolymers that carried identical terminal Neu5Acalpha2-3Gal fragments but varied by the structure of the next saccharide residues. A majority of duck viruses irrespective of their HA subtype, bound with the highest affinity to trisaccharide Neu5Acalpha2-3Galbeta1-3GlcNAc, suggesting that these viruses preferentially recognize sialyloligosaccharide receptors with type 1 core (Galbeta1-3GlcNAc). Substitution of 6-hydroxyl group of GlcNAc residue of tested sialylglycopolymers by 6-sulfo group had little effect on receptor binding by duck viruses. By contrast, H5N1 chicken and human viruses isolated in 1997 in Hong Kong preferred receptors with type 2 core (Galbeta1-4GlcNAcbeta) and bound sulfated trisaccharide Neu5Acalpha2-3Galbeta1-4(6-HSO3)GlcNAcbeta (6-Su-3'SLN) with the extraordinary high affinity. Another chicken virus, A/FPV/Rostok/34 (H7N1), and several mammalian viruses also displayed an increased affinity for sulfated sialyloligosaccharide receptor. The binding of chicken and mammalian viruses to tracheal epithelial cells of green monkey decreased after treatment of cells with glucosamine-6-sulfatase suggesting the presence of 6-O-Su-3'SLN determinants in the airway epithelium. It remains to be seen whether existence of the 6-O-Su-3'SLN groups in the human airway epithelial cells might facilitate infection of humans with H5N1 chicken viruses.

  9. Insights into Human Astrocyte Response to H5N1 Infection by Microarray Analysis

    Directory of Open Access Journals (Sweden)

    Xian Lin

    2015-05-01

    Full Text Available Influenza virus infects not only the respiratory system but also the central nervous system (CNS, leading to influenza-associated encephalopathy and encephalitis. Astrocytes are essential for brain homeostasis and neuronal function. These cells can also be infected by influenza virus. However, genome-wide changes in response to influenza viral infection in astrocytes have not been defined. In this study, we performed gene profiling of human astrocytes in response to H5N1. Innate immune and pro-inflammatory responses were strongly activated at 24 h post-infection (hpi. Antiviral genes, as well as several cytokines and chemokines, including CXCL9, CXCL10, and CXCL11, were robustly induced. Phosphorylation of p65 and p38 can be activated by viral infection, suggesting their potential critical roles in H5N1-induced pro-inflammatory response. Moreover, H5N1 infection significantly upregulated the gene expressions related to the neuroactive ligand-receptor interaction pathway at 24 hpi, such as MC2R, CHRNG, P2RY13, GABRA1, and HRH2, which participant in synaptic transmission and may take part in CNS disorders induced by H5N1 infection. Targeting key components of innate immune response and the neuroactive ligand-receptor interaction pathway may provide a strategy to control H5N1-induced encephalopathy and encephalitis. This research can contribute to the understanding of H5N1 pathogenesis in astrocytes.

  10. Distributive Justice among Hong Kong Chinese College Students.

    Science.gov (United States)

    Chiu, Chi-Yue

    1990-01-01

    Presents a naturalistic study involving 112 Hong Kong Chinese college psychology students who worked in small groups. Reveals the perceived fairness of all group members receiving the same grade related positively to group cohesiveness. Also shows students' endorsement of receiving same grade depends on low contributors' personality, previous…

  11. Cinematography in Motherhood: a Hong Kong film adaptation of Ghosts

    Directory of Open Access Journals (Sweden)

    Kwok-kan Tam

    2015-02-01

    Full Text Available This is a study of a Hong Kong Chinese film adaptation of Ghosts made in 1960. It deals with processes of cross-cultural and cross-media adaptation, and probes issues of how stage techniques are turned into cinematographic devices. Ibsen’s plays, except Ghosts, have been adapted numerous times for the Chinese stage and screen in Hong Kong and China. Unlike in China, the reception of Ibsen in Hong Kong is not meant for political purposes. In most Hong Kong adaptations, Ibsen is valued for the purpose of theatrical experimentation. Among the stage adaptations, A Doll’s House and The Master Builder are the most popular. However, there was a film adaptation of Ghosts in 1960, which has never been discussed in Ibsen scholarship. In this adaptation, Director Tso Kea borrowed the plot from Ghosts and made a perfect Chinese melodrama film highlighting the Chinese emotions and relations in a wealthy family that undergoes a crisis. In traditional Chinese drama, there is the lack of psychological rendering in characterization and characters act according to moral considerations. In Tso Kea’s film, the portrayal of the mother provides a new sense of characterization by combining Mrs Alving with the traditional Chinese mother figure. The borrowing from Ibsen makes it possible for the Chinese film to create a character with emotional and psychological complexities. Images from the film are selected as illustration in the article.

  12. Gender Differences in Financial Literacy among Hong Kong Workers

    Science.gov (United States)

    Yu, Kar-Ming; Wu, Alfred M.; Chan, Wai-Sum; Chou, Kee-Lee

    2015-01-01

    Using a phone survey conducted in 2012, we examined whether there is a gender difference in financial literacy among Hong Kong workers; and if such a difference exists, whether it can be explained by gender differences in sociodemographic variables, social or psychological factors, and/or the outcomes of retirement planning. Results show a gender…

  13. Difficulties with Team Teaching in Hong Kong Kindergartens

    Science.gov (United States)

    Ng, Mei Lee

    2015-01-01

    This article draws on qualitative classroom observation and interview data from a case study of one native-English speaker teacher (NEST) teaching in a Hong Kong kindergarten. Features of the NEST's teaching are identified, namely their professional limitations, their part-time involvement in teaching, and their limited collaboration with the…

  14. The Intercultural Approach in a Hong Kong Academic Setting

    Science.gov (United States)

    Cabau, Béatrice

    2015-01-01

    This article examines the various educational paradigms used in the design of a European studies undergraduate programme in Hong Kong to enhance the acquisition of intercultural competences (IC) among students. The intercultural approach is supported by intensive foreign language (FL) learning and is motivated by a compulsory full year academic…

  15. How Hong Kong Can Help China "Go Out"

    Institute of Scientific and Technical Information of China (English)

    Zhang Yuncheng

    2011-01-01

    Hong Kong has been a great help to the nation in its efforts to rejoin the .world community over the past 30 years since the beginning of "Reform and Opening Up" in 1978. It has played a unique role in helping the nation in implementing an exports-driven economy, improving industrial performance, upgrading technology, accumulating wealth, creating jobs,

  16. Online Independent Vocabulary Learning Experience of Hong Kong University Students

    Science.gov (United States)

    Tang, Eunice; Chung, Edsoulla; Li, Eddy; Yeung, Steven

    2016-01-01

    In response to the limited vocabulary size of its undergraduates, an independent vocabulary learning platform, VLearn was designed and launched in a university in Hong Kong. As an e-learning environment that supports self-directed vocabulary learning of Chinese learners, the primary aim of VLearn is to equip users with appropriate knowledge and…

  17. Multicultural Hong Kong: Alternative New Media Representations of Ethnic Minorities

    Science.gov (United States)

    Jackson, Liz; Nesterova, Yulia

    2017-01-01

    Racial and ethnic minorities experience misrecognition, prejudice and discrimination in Hong Kong. In response to these challenges, multicultural education there aims to enable young people to recognize diversity in a more tolerant, open-minded way. Educators have been encouraged to not rely only on textbooks, but to include news and digital media…

  18. Nursing Stress and Coping Patterns in Hong Kong.

    Science.gov (United States)

    Hung, Beatrice K. M.; Lee, Peter W. H.

    The role of nurses in providing patient care is both instrumental and expressive. Fulfillment of these dual roles depends on the psychosocial and physical well-being of nurses. This study examined the stress experience of nurses in Hong Kong. Various factors affecting the experience of stress and the coping strategies adopted were also…

  19. Sustainable Development Index in Hong Kong: Approach, Method and Findings

    Science.gov (United States)

    Tso, Geoffrey K. F.; Yau, Kelvin K. W.; Yang, C. Y.

    2011-01-01

    Sustainable development is a priority area of research in many countries and regions nowadays. This paper illustrates how a multi-stakeholders engagement process can be applied to identify and prioritize the local community's concerns and issues regarding sustainable development in Hong Kong. Ten priority areas covering a wide range of community's…

  20. Secondary School Students' Views of Climate Change in Hong Kong

    Science.gov (United States)

    Jackson, Liz; Pang, Ming-Fai

    2017-01-01

    Though there has been an increased focus on climate change in Hong Kong's educational policy and curriculum over the last decade, little is known about the impact of curricular implementation on young people's environmental and climate change-related views, attitudes, awareness, or behaviors. This paper examines the state of climate change…

  1. Active Ageing, Active Learning: Policy and Provision in Hong Kong

    Science.gov (United States)

    Tam, M.

    2011-01-01

    This paper discusses the relationship between ageing and learning, previous literature having confirmed that participation in continued learning in old age contributes to good health, satisfaction with life, independence and self-esteem. Realizing that learning is vital to active ageing, the Hong Kong government has implemented policies and…

  2. Ageing, Loss, and Learning: Hong Kong and Australian Seniors

    Science.gov (United States)

    Boulton-Lewis, Gillian M.; Pike, Lucinda; Tam, Maureen; Buys, Laurie

    2017-01-01

    In this article, the discussion of loss and its relationship to learning is based on the analysis of interview data from 39 older adults in Hong Kong and 40 in Australia. The focus of the research was on ageing and learning. The phenomenon of life changes, specifically losses, and their relationship to learning was frequently mentioned, and this…

  3. Paradigms, Perspectives and Dichotomies amongst Teacher Educators in Hong Kong

    Science.gov (United States)

    Katyal, Kokila Roy; Fai, Pang Ming

    2010-01-01

    This paper argues that the concepts, beliefs and understandings of local and non-local teacher educators in a Hong Kong university are grounded in their own cultural cognition and antecedents. It presents the viewpoint that contemporary notions of good practice were compromised when applied to a context that is strongly influenced by the tenets of…

  4. Conceptions of Creativity among Hong Kong University Students

    Science.gov (United States)

    Zhang, Li-fang

    2013-01-01

    This research had two objectives. The first was to determine the reliability and validity of the multifaceted assessment of creativity (MAC) for evaluating Hong Kong university students' conceptions of creativity. The second was to establish if the theory-practice and gender gaps discovered among mainland Chinese university students would be…

  5. Students' and Faculty's Perception of Academic Integrity in Hong Kong

    Science.gov (United States)

    Kwong, Theresa; Ng, Hing-Man; Kai-Pan, Mark; Wong, Eva

    2010-01-01

    Purpose: The purpose of this paper is to compare students' and faculty members' perceptions of academic integrity; their understanding of experiences pertaining to different aspects of academic misconduct (e.g. plagiarism); and to examine the underlying reasons behind academic integrity violations in a Hong Kong context.…

  6. Challenges to Values Education in Hong Kong School Music Education

    Science.gov (United States)

    Ho, Wai-Chung

    2006-01-01

    This study deals with the issue of incorporating values education in music education in Hong Kong's primary and secondary schools. It includes the development of the state's cultural and national identity since its handover from the United Kingdom to the People's Republic of China (PRC). Thirty primary and secondary school music teachers were…

  7. Political disempowerment among older people in Hong Kong.

    Science.gov (United States)

    Kam, P K

    2000-01-01

    The democratic elections that took place in Hong Kong before and after 1997 presented a unique opportunity for older people, politicians and government officials to take action to promote the participation of older people. There were, however, few significant projects undertaken to this end. This paper reports on recent research on political participation of older people in Hong Kong which found that they were active in voting but they were passive in other forms of participation. Factors affecting participation are more significantly related to politicians' mobilization than to civic education or work done by centres for the elderly. In the field, there is little awareness of using more effective strategies to address older people's political powerlessness. Strategies identified include: educational talks in local elderly centres, mock election games and meeting with candidates from different political parties. All these activities were locally based and not well articulated, and there were few concerted efforts to promote the political power and influence of older people at the central level. The present situation of older people in Hong Kong remains one of political powerlessness and the piecemeal strategies used to address the issue have so far had little impact. This paper suggests that political powerlessness is not a natural result of old age. It is a problem which is socially constructed. An analysis of the factors shaping this situation is presented. It also presents some suggested strategies for gerontological practice in promoting political empowerment among older people in Hong Kong.

  8. Hong Kong and Australian Seniors: Views of Aging and Learning

    Science.gov (United States)

    Boulton-Lewis, Gillian M.; Tam, M.; Buys, Laurie; Chui, Ernest Wing-tak

    2016-01-01

    This article reports on the findings of qualitative, semistructured interviews conducted with 40 older Australian participants and 39 participants in Hong Kong who either did or did not engage in organized learning in the last 6 months. Phenomenology was used to guide the interviews and analysis to explore the experiences and perspectives of these…

  9. VIRTUAL WORLD OF CULTURAL MEMORY: HONG KONG VARIANT

    Directory of Open Access Journals (Sweden)

    Tolkacheva, V.A.

    2016-07-01

    Full Text Available The article considers ways and forms of cultural memory preservation of Hong Kong as the unique place which harmoniously combines features of the European and Asian cultures for many years. Who are they: Chinese or Europeans? What do they prefer to remember about themselves?

  10. Teaching Business Ethics in Hong Kong: Challenges and Response.

    Science.gov (United States)

    McCann, Dennis P.; Lam, Joanna Kit Chun; Chiu, Randy K.

    2001-01-01

    Describes a program for teaching business ethics to undergraduate business students at the Hong Kong Baptist University. Provides an anecdotal account to illustrate that in non-Western cultural contexts, figurative rather than scientific language often captures the essence of qualitative phenomena. Underscores the importance of understanding and…

  11. The Determinants of Hiring Older Workers: Evidence from Hong Kong.

    Science.gov (United States)

    Heywood, John S.; Ho, Lok-Sang; Wei, Xiangdong

    1999-01-01

    A survey of 770 Hong Kong firms showed that, in a developed economy with little government intervention, many companies employed older workers but were not hiring new ones. Firms were more likely to invest in training when workers were young. Delayed compensation was more acceptable to younger workers. (SK)

  12. Life Satisfaction and Family Structure among Adolescents in Hong Kong

    Science.gov (United States)

    Kwan, Ying-Keung

    2008-01-01

    Relationships between family structure and perceived life satisfaction in overall life and five domains of the Brief Multidimensional Students' Life Satisfaction Scale, family life, friendships, school experience, myself, and where I live were examined among 4,502 Chinese adolescent secondary school students in Hong Kong. Bivariate analyses showed…

  13. Communication in Hong Kong Accident and Emergency Departments

    Directory of Open Access Journals (Sweden)

    Eloise Chandler

    2015-03-01

    Full Text Available In this article, we report findings from the first qualitatively driven study of patient–clinician communication in Hong Kong Accident and Emergency Departments (AEDs. In light of the Hong Kong Hospital Authority’s policy emphasis on patient-centered care and communication in the public hospitals it oversees, we analyze clinicians’ perceptions of the role and relevance of patient-centered communication strategies in emergency care. Although aware of the importance of effective communication in emergency care, participants discussed how this was frequently jeopardized by chronic understaffing, patient loads, and time pressures. This was raised in relation to the absence of spoken interdisciplinary handovers, the tendency to downgrade interpersonal communication with patients, and the decline in staff attendance at communication training courses. Participants’ frequent descriptions of patient-centered communication as dispensable from, and time-burdensome in, AEDs highlight a discrepancy between the stated Hong Kong Hospital Authority policy of patient-centered care and the reality of contemporary Hong Kong emergency practice.

  14. Attitudes toward Suicide among Chinese People in Hong Kong

    Science.gov (United States)

    Lee, Sing; Tsang, Adley; Li, Xian-yun; Phillips, Michael Robert; Kleinman, Arthur

    2007-01-01

    Since suicide in Chinese people exhibits certain distinctive characteristics, it is important to develop indigenous measures to assess Chinese attitudes toward suicide that may be used to inform suicide reduction programs. Combining qualitative and quantitative methods, we developed a Hong Kong version of the Chinese Attitude toward Suicide…

  15. Foreignizing Translation and Domesticating Translation of Hong Kong Movie Titles

    Institute of Scientific and Technical Information of China (English)

    林慧韵

    2014-01-01

    Generally,the movie title translation strategy would be divided into two:domesticating translation strategy and foreignizing translation strategy.The movie title translation in Hong Kong is chosen to be the material for the analysis of the domesticating translation strategy and foreignizing translation strategy,compared with that of Mainland China.

  16. Institutional Potential for Online Learning: A Hong Kong Case Study

    Science.gov (United States)

    Donoghue, Sue L.

    2006-01-01

    Hong Kong's tertiary education environment has changed dramatically in recent years with universities now facing specific educational challenges in the areas of critical thinking, "life-long learning" and English language. The question exists as to what pedagogic developments will best allow the universities to address these challenges.…

  17. Role Management Strategies of Beginning Teachers in Hong Kong

    Science.gov (United States)

    Choi, Pik Lin; Tang, Sylvia Yee Fan

    2005-01-01

    Beginning teachers encounter new challenges as the role system in contemporary society has become more and more demanding. By means of the life history method, role management strategies of four Hong Kong beginning teachers employed to cope with role demands and intra-role conflicts were located in their biographical, workplace and wider…

  18. Managing Chinese Catalogingat The Hong Kong Polytechnic University Library

    Institute of Scientific and Technical Information of China (English)

    NoraFung

    1994-01-01

    This paper describes the experience and the observation of the author as a cataloger of Chinese publications at The Hong Kong Polytechnic University, Library. The trends in collection development of Chinese language materials in the Library have a crucial impact on Chinese cataloging. The way that Chinese cataloging has been haudled in this rapidly changing environment is reported here.

  19. Sustainable Development Index in Hong Kong: Approach, Method and Findings

    Science.gov (United States)

    Tso, Geoffrey K. F.; Yau, Kelvin K. W.; Yang, C. Y.

    2011-01-01

    Sustainable development is a priority area of research in many countries and regions nowadays. This paper illustrates how a multi-stakeholders engagement process can be applied to identify and prioritize the local community's concerns and issues regarding sustainable development in Hong Kong. Ten priority areas covering a wide range of community's…

  20. Undergraduates' Career Perceptions and First Job Needs in Hong Kong.

    Science.gov (United States)

    Lau, Agnes; Pang, Mary

    1995-01-01

    Focus groups (n=23) and survey responses (n=492) of Hong Kong business graduates reveal a belief that intrinsic and extrinsic rewards are important, but they tend to make job rather than career decisions, seek extrinsic rewards in initial jobs, lack commitment to organizations, have a short-term perspective, and focus on gaining exposure and…

  1. Barriers Impacting Students with Disabilities at a Hong Kong University

    Science.gov (United States)

    Gilson, Christie L.; Dymond, Stacy K.

    2012-01-01

    A qualitative study was conducted to examine the barriers to postsecondary education experienced by students with disabilities in Hong Kong and the impact of those barriers. Data were gathered from six students with disabilities, their instructors, and university staff with whom they interacted to procure disability-related services using…

  2. Is avian influenza virus A(H5N1) a real threat to human health?

    Science.gov (United States)

    Amendola, A; Ranghiero, A; Zanetti, A; Pariani, E

    2011-09-01

    The A(H5N1) influenza remains a disease of birds with a significant species barrier: in the presence of some tens million cases of infection in poultry--with a wide geographical spread--, only a few hundreds cases have occurred in humans. To date, human cases have been reported in 15 countries--mainly in Asia--and all were related to the onset of outbreaks in poultry. A peak of H5N1 human cases was recorded in 2006, then decreasing in subsequent years. Despite this trend, the H5N1 virus still represents a possible threat to human health, considering that more than half of human cases of H5N1 have been fatal. Moreover, despite the drop in the number of cases, the risk of a novel pandemic cannot be excluded, since H5N1 continues to circulate in poultry in countries with elevated human population density and where monitoring systems are not fully appropriate. In addition, there is a major global concern about the potential occurrence of a reassortment between the 2009 pandemic H1N1 and the highly pathogenic H5N1 influenza viruses following a co-infection in a susceptible host. Therefore, the implementation of appropriate surveillance and containment measures is crucial in order to minimize such risk. In conclusion, H5N1 avian influenza is still a rare disease in humans but its clinical severe outcome requires a careful monitoring of the virus's ability to evolve and to trigger a new pandemic.

  3. Highly Pathogenic Avian Influenza H5N1 in Mainland China.

    Science.gov (United States)

    Li, Xin-Lou; Liu, Kun; Yao, Hong-Wu; Sun, Ye; Chen, Wan-Jun; Sun, Ruo-Xi; de Vlas, Sake J; Fang, Li-Qun; Cao, Wu-Chun

    2015-05-08

    Highly pathogenic avian influenza (HPAI) H5N1 has posed a significant threat to both humans and birds, and it has spanned large geographic areas and various ecological systems throughout Asia, Europe and Africa, but especially in mainland China. Great efforts in control and prevention of the disease, including universal vaccination campaigns in poultry and active serological and virological surveillance, have been undertaken in mainland China since the beginning of 2006. In this study, we aim to characterize the spatial and temporal patterns of HPAI H5N1, and identify influencing factors favoring the occurrence of HPAI H5N1 outbreaks in poultry in mainland China. Our study shows that HPAI H5N1 outbreaks took place sporadically after vaccination campaigns in poultry, and mostly occurred in the cold season. The positive tests in routine virological surveillance of HPAI H5N1 virus in chicken, duck, goose as well as environmental samples were mapped to display the potential risk distribution of the virus. Southern China had a higher positive rate than northern China, and positive samples were mostly detected from chickens in the north, while the majority were from duck in the south, and a negative correlation with monthly vaccination rates in domestic poultry was found (R = -0.19, p value = 0.005). Multivariate panel logistic regression identified vaccination rate, interaction between distance to the nearest city and national highway, interaction between distance to the nearest lake and wetland, and density of human population, as well as the autoregressive term in space and time as independent risk factors in the occurrence of HPAI H5N1 outbreaks, based on which a predicted risk map of the disease was derived. Our findings could provide new understanding of the distribution and transmission of HPAI H5N1 in mainland China and could be used to inform targeted surveillance and control efforts in both human and poultry populations to reduce the risk of future infections.

  4. Waterfowl potential as resevoirs of high pathogenic avian influenza H5N1 viruses

    Directory of Open Access Journals (Sweden)

    R Susanti

    2007-06-01

    Full Text Available The high population of waterfowl subsequently with the high case fatality of poultry and people in West Java regency caused by HPAI H5N1 can raise possibility that waterfowl was a natural reservoir. This research aimed to prove that waterfowl in West Java served as reservoir of AI virus (primarily H5N1 and also identify the virus pathotype based on cleavage site of amino acid sequence. Cloacal swab sample was obtained from healthy and unvaccinated waterfowl from Sukabumi and Bogor Regency. Cloacal swab was propagated in 9 days old embryonic chicken eggs. Allantoic fluid was harvested at the 4th day of incubation and then tested for hemagglutination, and positive isolate continued with virus sub-typing using PCR method. H5 gene from H5N1 isolate then sequenced using dideoxy termination method. Multiple alignment of nucleotide sequences were analysed using MEGA-3.1 program. Sub-typing using PCR method indicated the existence of 25 strain H5N1, 16 strain HxN1, 4 strain H5Nx and 9 virus ND. Characterization of cleavage site amino acid sequence indicated that all H5N1 sample were pathogenic with sequence QRERRRKKR (23 sample dan QRESRRKKR (2 sample. Waterfowl was HPAI H5N1 virus reservoir. Asymptomatic infection in waterfowl, but the virus shedding gradually occurred and therefore it became potential source of H5N1 virus infection. Our findings suggest that immediate action is needed to prevent the transmission of highly pathogenic avian influenza viruses from the apparently healthy waterfowl into terrestrial poultry or human.

  5. Restructuring Hong Kong's Schools: The Applicability of Western Theories, Policies, and Practices to an Asian Culture.

    Science.gov (United States)

    Dimmock, Clive

    1998-01-01

    Explores the appropriateness and synchrony between educational policy reforms imported into Hong Kong and central features of the host culture. Draws upon Geert Hofstede's cultural dimensions to provide a framework for identifying and matching Hong Kong's culture in juxtaposition with other cultures. Despite powerful Western influences, Hong Kong…

  6. Global distribution patterns of highly pathogenic H5N1 avian influenza: environmental vs. socioeconomic factors.

    Science.gov (United States)

    Chen, Youhua; Chen, You-Fang

    2014-01-01

    In this report, we quantitatively analyzed the essential ecological factors that were strongly correlated with the global outbreak of highly pathogenic H5N1 avian influenza. The ecological niche modeling (ENM) was used to reveal the potential outbreak hotspots of H5N1. A two-step modeling procedure has been proposed: we first used BioClim model to obtain the coarse suitable areas of H5N1, and then those suitable areas with very high probabilities were retained as the inputs of multiple-variable autologistic regression analysis (MAR) for model refinement. MAR was implemented taking spatial autocorrelation into account. The final performance of ENM was evaluated using the areas under the curve (AUC) of receiver-operating characteristic. In addition, principal component analysis (PCA) was employed to reveal the most important variables and relevant ecological gradients of H5N1 outbreak. Niche visualization was used to identify potential spreading trend of H5N1 along important ecological gradients. For the first time, we combined socioeconomic and environmental variables as joint predictors in developing ecological niche modeling. Environmental variables represented the natural element related to H5N1 outbreak, whereas socioeconomic ones represented the anthropogenic element. Our results indicated that: (1) the high-risk hotspots are mainly located in temperate zones (indicated by ENM)-correspondingly, we argued that the "ecoregions hypothesis" was reasonable to some extent; (2) evaporation, humidity, human population density, livestock population density were the first four important factors (in descending order) that were associated with the H5N1 global outbreak (indicated by PCA); (3) influenza had a tendency to expand into areas with low evaporation (indicated by niche visualization). In conclusion, our study substantiates that both the environmental and socioeconomic variables jointly determined the global spreading trend of H5N1, but environmental variables

  7. Estimation of transmission parameters of H5N1 avian influenza virus in chickens.

    Directory of Open Access Journals (Sweden)

    Annemarie Bouma

    2009-01-01

    Full Text Available Despite considerable research efforts, little is yet known about key epidemiological parameters of H5N1 highly pathogenic influenza viruses in their avian hosts. Here we show how these parameters can be estimated using a limited number of birds in experimental transmission studies. Our quantitative estimates, based on Bayesian methods of inference, reveal that (i the period of latency of H5N1 influenza virus in unvaccinated chickens is short (mean: 0.24 days; 95% credible interval: 0.099-0.48 days; (ii the infectious period of H5N1 virus in unvaccinated chickens is approximately 2 days (mean: 2.1 days; 95%CI: 1.8-2.3 days; (iii the reproduction number of H5N1 virus in unvaccinated chickens need not be high (mean: 1.6; 95%CI: 0.90-2.5, although the virus is expected to spread rapidly because it has a short generation interval in unvaccinated chickens (mean: 1.3 days; 95%CI: 1.0-1.5 days; and (iv vaccination with genetically and antigenically distant H5N2 vaccines can effectively halt transmission. Simulations based on the estimated parameters indicate that herd immunity may be obtained if at least 80% of chickens in a flock are vaccinated. We discuss the implications for the control of H5N1 avian influenza virus in areas where it is endemic.

  8. A SPR aptasensor for detection of avian influenza virus H5N1.

    Science.gov (United States)

    Bai, Hua; Wang, Ronghui; Hargis, Billy; Lu, Huaguang; Li, Yanbin

    2012-01-01

    Rapid and specific detection of avian influenza virus (AIV) is urgently needed due to the concerns over the potential outbreaks of highly pathogenic H5N1 influenza in animals and humans. Aptamers are artificial oligonucleic acids that can bind specific target molecules, and show comparable affinity for target viruses and better thermal stability than monoclonal antibodies. The objective of this research was to use a DNA-aptamer as the specific recognition element in a portable Surface Plasmon Resonance (SPR) biosensor for rapid detection of AIV H5N1 in poultry swab samples. A SPR biosensor was fabricated using selected aptamers that were biotinylated and then immobilized on the sensor gold surface coated with streptavidin via streptavidin-biotin binding. The immobilized aptamers captured AIV H5N1 in a sample solution, which caused an increase in the refraction index (RI). After optimizing the streptavidin and aptamer parameters, the results showed that the RI value was linearly related (R(2) = 0.99) to the concentration of AIV in the range of 0.128 to 1.28 HAU. Negligible signal (H5N1) was observed from six non-target AIV subtypes. The AIV H5N1 in poultry swab samples with concentrations of 0.128 to 12.8 HAU could be detected using this aptasensor in 1.5 h.

  9. A SPR Aptasensor for Detection of Avian Influenza Virus H5N1

    Directory of Open Access Journals (Sweden)

    Huaguang Lu

    2012-09-01

    Full Text Available Rapid and specific detection of avian influenza virus (AIV is urgently needed due to the concerns over the potential outbreaks of highly pathogenic H5N1 influenza in animals and humans. Aptamers are artificial oligonucleic acids that can bind specific target molecules, and show comparable affinity for target viruses and better thermal stability than monoclonal antibodies. The objective of this research was to use a DNA-aptamer as the specific recognition element in a portable Surface Plasmon Resonance (SPR biosensor for rapid detection of AIV H5N1 in poultry swab samples. A SPR biosensor was fabricated using selected aptamers that were biotinylated and then immobilized on the sensor gold surface coated with streptavidin via streptavidin-biotin binding. The immobilized aptamers captured AIV H5N1 in a sample solution, which caused an increase in the refraction index (RI. After optimizing the streptavidin and aptamer parameters, the results showed that the RI value was linearly related (R2 = 0.99 to the concentration of AIV in the range of 0.128 to 1.28 HAU. Negligible signal ( < 4% of H5N1 was observed from six non-target AIV subtypes. The AIV H5N1 in poultry swab samples with concentrations of 0.128 to 12.8 HAU could be detected using this aptasensor in 1.5 h.

  10. Rapid and highly informative diagnostic assay for H5N1 influenza viruses.

    Directory of Open Access Journals (Sweden)

    Nader Pourmand

    Full Text Available A highly discriminative and information-rich diagnostic assay for H5N1 avian influenza would meet immediate patient care needs and provide valuable information for public health interventions, e.g., tracking of new and more dangerous variants by geographic area as well as avian-to-human or human-to-human transmission. In the present study, we have designed a rapid assay based on multilocus nucleic acid sequencing that focuses on the biologically significant regions of the H5N1 hemagglutinin gene. This allows the prediction of viral strain, clade, receptor binding properties, low- or high-pathogenicity cleavage site and glycosylation status. H5 HA genes were selected from nine known high-pathogenicity avian influenza subtype H5N1 viruses, based on their diversity in biologically significant regions of hemagglutinin and/or their ability to cause infection in humans. We devised a consensus pre-programmed pyrosequencing strategy, which may be used as a faster, more accurate alternative to de novo sequencing. The available data suggest that the assay described here is a reliable, rapid, information-rich and cost-effective approach for definitive diagnosis of H5N1 avian influenza. Knowledge of the predicted functional sequences of the HA will enhance H5N1 avian influenza surveillance efforts.

  11. Isolation and characterization of highly pathogenic avian influenza virus subtype H5N1 from donkeys

    Directory of Open Access Journals (Sweden)

    Abdel-Ghany Ahmad E

    2010-04-01

    Full Text Available Abstract Background The highly pathogenic H5N1 is a major avian pathogen that crosses species barriers and seriously affects humans as well as some mammals. It mutates in an intensified manner and is considered a potential candidate for the possible next pandemic with all the catastrophic consequences. Methods Nasal swabs were collected from donkeys suffered from respiratory distress. The virus was isolated from the pooled nasal swabs in specific pathogen free embryonated chicken eggs (SPF-ECE. Reverse transcriptase polymerase chain reaction (RT-PCR and sequencing of both haemagglutingin and neuraminidase were performed. H5 seroconversion was screened using haemagglutination inhibition (HI assay on 105 donkey serum samples. Results We demonstrated that H5N1 jumped from poultry to another mammalian host; donkeys. Phylogenetic analysis showed that the virus clustered within the lineage of H5N1 from Egypt, closely related to 2009 isolates. It harboured few genetic changes compared to the closely related viruses from avian and humans. The neuraminidase lacks oseltamivir resistant mutations. Interestingly, HI screening for antibodies to H5 haemagglutinins in donkeys revealed high exposure rate. Conclusions These findings extend the host range of the H5N1 influenza virus, possess implications for influenza virus epidemiology and highlight the need for the systematic surveillance of H5N1 in animals in the vicinity of backyard poultry units especially in endemic areas.

  12. Widespread of H5N1 infections in apparently healthy backyard poultry.

    Science.gov (United States)

    Abozaid, Khaled G A; Aly, Mona M; Abdel-Moneim, Ahmed S; El-Kady, Magdy F

    2016-08-01

    Highly pathogenic avian influenza subtype H5N1 represents a threat to the poultry industry and human health worldwide. Inapparently infected birds are suspected to play an essential role in the spread of avian influenza virus. In the current study, a total of 25,646 samples (16,185 chicken, 4696 ducks, 1633 geese and 3132 turkeys) from apparently healthy birds were screened for the presence of positive samples for H5N1 during 2009-2014. The samples were examined by reverse transcriptase real-time polymerase chain reaction (rRT-PCR) for M, H5 and N1 genes of avian influenza viruses. The results revealed that the HPAI H5N1 existed in an inapparent manner in ducks (4.68 %), geese (4.10 %), chickens (2.48 %) and turkeys (2.29 %). The current finding highlights the serious impact of such type on birds in the epidemiology of H5N1 in birds, animals and humans. It also highlights the existence of another reason other than vaccination that contributes to the widespread of inapparent infection of H5N1 in Egypt.

  13. Greater virulence of highly pathogenic H5N1 influenza virus in cats than in dogs.

    Science.gov (United States)

    Kim, Heui Man; Park, Eun Hye; Yum, Jung; Kim, Hyun Soo; Seo, Sang Heui

    2015-01-01

    Highly pathogenic H5N1 influenza virus continues to infect animals and humans. We compared the infectivity and pathogenesis of H5N1 virus in domestic cats and dogs to find out which animal is more susceptible to H5N1 influenza virus. When cats and dogs were infected with the H5N1 virus, cats suffered from severe outcomes including death, whereas dogs did not show any mortality. Viruses were shed in the nose and rectum of cats and in the nose of dogs. Viruses were detected in brain, lung, kidney, intestine, liver, and serum in the infected cats, but only in the lung in the infected dogs. Genes encoding inflammatory cytokines and chemokines, Toll-like receptors, and apoptotic factors were more highly expressed in the lungs of cats than in those of dogs. Our results suggest that the intensive monitoring of dogs is necessary to prevent human infection by H5N1 influenza virus, since infected dogs may not show clear clinical signs, in contrast to infected cats.

  14. Avian Influenza A(H5N1) Virus in Egypt.

    Science.gov (United States)

    Kayali, Ghazi; Kandeil, Ahmed; El-Shesheny, Rabeh; Kayed, Ahmed S; Maatouq, Asmaa M; Cai, Zhipeng; McKenzie, Pamela P; Webby, Richard J; El Refaey, Samir; Kandeel, Amr; Ali, Mohamed A

    2016-03-01

    In Egypt, avian influenza A subtype H5N1 and H9N2 viruses are enzootic in poultry. The control plan devised by veterinary authorities in Egypt to prevent infections in poultry focused mainly on vaccination and ultimately failed. Recently, widespread H5N1 infections in poultry and a substantial increase in the number of human cases of H5N1 infection were observed. We summarize surveillance data from 2009 through 2014 and show that avian influenza viruses are established in poultry in Egypt and are continuously evolving genetically and antigenically. We also discuss the epidemiology of human infection with avian influenza in Egypt and describe how the true burden of disease is underestimated. We discuss the failures of relying on vaccinating poultry as the sole intervention tool. We conclude by highlighting the key components that need to be included in a new strategy to control avian influenza infections in poultry and humans in Egypt.

  15. Mx1 gene protects mice against the highly lethal human H5N1 influenza virus.

    Science.gov (United States)

    Salomon, Rachelle; Staeheli, Peter; Kochs, Georg; Yen, Hui-Ling; Franks, John; Rehg, Jerold E; Webster, Robert G; Hoffmann, Erich

    2007-10-01

    We investigated the importance of the host Mx1 gene in protection against highly pathogenic H5N1 avian influenza virus. Mice expressing the Mx1 gene survived infection with the lethal human H5N1 isolate A/Vietnam/1203/04 and with reassortants combining its genes with those of the non-lethal virus A/chicken/Vietnam/C58/04, while all Mx1-/- mice succumbed. Mx1-expressing mice showed lower organ virus titers, fewer lesions, and less pulmonary inflammation. Our data support the hypothesis that Mx1 expression protects mice against the high pathogenicity of H5N1 virus through inhibition of viral polymerase activity ultimately resulting in reduced viral growth and spread. Drugs that mimic this mechanism may be protective in humans.

  16. Singing the Praise of Hong Kong’s Return——A Hong Kong chorus visits Beijing

    Institute of Scientific and Technical Information of China (English)

    1997-01-01

    AN 82-member Hong Kong chorus recently held a concert in Beijing to express their happiness at Hong Kong’s return to China. The Hong Kong Arts Chorus entitled their concert, "When the wind sweeps through, paddy fields produce fragrance to merge both banks--hail the return of Hong Kong." The verse which the chorus had adopted as the title of their concert in Beijing comes from a well-known song on the mainland,"My Motherland." By adopting this famous

  17. Seasonal patterns in human A (H5N1 virus infection: analysis of global cases.

    Directory of Open Access Journals (Sweden)

    Maya B Mathur

    Full Text Available Human cases of highly pathogenic avian influenza (HPAI A (H5N1 have high mortality. Despite abundant data on seasonal patterns in influenza epidemics, it is unknown whether similar patterns exist for human HPAI H5N1 cases worldwide. Such knowledge could help decrease avian-to-human transmission through increased prevention and control activities during peak periods.We performed a systematic search of published human HPAI H5N1 cases to date, collecting month, year, country, season, hemisphere, and climate data. We used negative binomial regression to predict changes in case incidence as a function of season. To investigate hemisphere as a potential moderator, we used AIC and the likelihood-ratio test to compare the season-only model to nested models including a main effect or interaction with hemisphere. Finally, we visually assessed replication of seasonal patterns across climate groups based on the Köppen-Geiger climate classification.We identified 617 human cases (611 with complete seasonal data occurring in 15 countries in Southeast Asia, Africa, and the Middle East. Case occurrence was much higher in winter (n = 285, p = 0.03 than summer (n = 64, and the winter peak occurred across diverse climate groups. There was no significant interaction between hemisphere and season.Across diverse climates, HPAI H5N1 virus infection in humans increases significantly in winter. This is consistent with increased poultry outbreaks and HPAI H5N1 virus transmission during cold and dry conditions. Prioritizing prevention and control activities among poultry and focusing public health messaging to reduce poultry exposures during winter months may help to reduce zoonotic transmission of HPAI H5N1 virus in resource-limited settings.

  18. Isolation of avian influenza H5N1 virus from vaccinated commercial layer flock in Egypt

    Directory of Open Access Journals (Sweden)

    El-Zoghby Elham F

    2012-11-01

    Full Text Available Abstract Background Uninterrupted transmission of highly pathogenic avian influenza virus (HPAIV H5N1 of clade 2.2.1 in Egypt since 2006 resulted in establishment of two main genetic clusters. The 2.2.1/C group where all recent human and majority of backyard origin viruses clustered together, meanwhile the majority of viruses derived from vaccinated poultry in commercial farms grouped in 2.2.1.1 clade. Findings In the present investigation, an HPAIV H5N1 was isolated from twenty weeks old layers chickens that were vaccinated with a homologous H5N1 vaccine at 1, 7 and 16 weeks old. At twenty weeks of age, birds showed cyanosis of comb and wattle, decrease in egg production and up to 27% mortality. Examined serum samples showed low antibody titer in HI test (Log2 3.2± 4.2. The hemagglutinin (HA and neuraminidase (NA genes of the isolated virus were closely related to viruses in 2.2.1/C group isolated from poultry in live bird market (LBM and backyards or from infected people. Conspicuous mutations in the HA and NA genes including a deletion within the receptor binding domain in the HA globular head region were observed. Conclusions Despite repeated vaccination of layer chickens using a homologous H5N1 vaccine, infection with HPAIV H5N1 resulted in significant morbidity and mortality. In endemic countries like Egypt, rigorous control measures including enforcement of biosecurity, culling of infected birds and constant update of vaccine virus strains are highly required to prevent circulation of HPAIV H5N1 between backyard birds, commercial poultry, LBM and humans.

  19. Characterization of low-pathogenicity H5N1 avian influenza viruses from North America

    Science.gov (United States)

    Spackman, Erica; Swayne, David E.; Suarez, David L.; Senne, Dennis A.; Pedersen, Janice C.; Killian, Mary Lea; Pasick, John; Handel, Katherine; Somanathan Pillai, Smitha; Lee, Chang-Won; Stallknecht, David; Slemons, Richard; Ip, Hon S.; Deliberto, Tom

    2007-01-01

    Wild-bird surveillance in North America for avian influenza (AI) viruses with a goal of early identification of the Asian H5N1 highly pathogenic AI virus has identified at least six low-pathogenicity H5N1 AI viruses between 2004 and 2006. The hemagglutinin (HA) and neuraminidase (NA) genes from all 6 H5N1 viruses and an additional 38 North American wild-bird-origin H5 subtype and 28 N1 subtype viruses were sequenced and compared with sequences available in GenBank by phylogenetic analysis. Both HA and NA were phylogenetically distinct from those for viruses from outside of North America and from those for viruses recovered from mammals. Four of the H5N1 AI viruses were characterized as low pathogenicity by standard in vivo pathotyping tests. One of the H5N1 viruses, A/MuteSwan/MI/451072-2/06, was shown to replicate to low titers in chickens, turkeys, and ducks. However, transmission of A/MuteSwan/MI/451072-2/06 was more efficient among ducks than among chickens or turkeys based on virus shed. The 50% chicken infectious dose for A/MuteSwan/MI/451072-2/06 and three other wild-waterfowl-origin H5 viruses were also determined and were between 105.3 and 107.5 50% egg infective doses. Finally, seven H5 viruses representing different phylogenetic clades were evaluated for their antigenic relatedness by hemagglutination inhibition assay, showing that the antigenic relatedness was largely associated with geographic origin. Overall, the data support the conclusion that North American H5 wild-bird-origin AI viruses are low-pathogenicity wild-bird-adapted viruses and are antigenically and genetically distinct from the highly pathogenic Asian H5N1 virus lineage.

  20. Characterization of low-pathogenicity H5N1 avian influenza viruses from North America

    Science.gov (United States)

    Spackman, Erica; Swayne, D. E.; Suarez, D. L.; Senne, D. A.; Pedersen, J. C.; Killian, M. L.; Pasick, J.; Handel, K.; Pillai, S. P. S.; Lee, C. -W.; Stallknecht, D.; Slemons, R.; Ip, H. S.; Deliberto, T.

    2007-01-01

    Wild-bird surveillance in North America for avian influenza (AI) viruses with a goal of early identification of the Asian H5N1 highly pathogenic AI virus has identified at least six low-pathogenicity H5N1 AI viruses between 2004 and 2006. The hemagglutinin (HA) and neuraminidase (NA) genes from all 6 H5N1 viruses and an additional 38 North American wild-bird-origin H5 subtype and 28 N1 subtype viruses were sequenced and compared with sequences available in GenBank by phylogenetic analysis. Both HA and NA were phylogenetically distinct from those for viruses from outside of North America and from those for viruses recovered from mammals. Four of the H5N1 AI viruses were characterized as low pathogenicity by standard in vivo pathotyping tests. One of the H5N1 viruses, A/MuteSwan/MI/451072-2/06, was shown to replicate to low titers in chickens, turkeys, and ducks. However, transmission of A/MuteSwan/MI/451072-2/06 was more efficient among ducks than among chickens or turkeys based on virus shed. The 50% chicken infectious dose for A/MuteSwan/MI/451072-2/06 and three other wild-waterfowl-origin H5 viruses were also determined and were between 10 5.3 and 107.5 50% egg infective doses. Finally, seven H5 viruses representing different phylogenetic clades were evaluated for their antigenic relatedness by hemagglutination inhibition assay, showing that the antigenic relatedness was largely associated with geographic origin. Overall, the data support the conclusion that North American H5 wild-bird-origin AI viruses are low-pathogenicity wild-bird-adapted viruses and are antigenically and genetically distinct from the highly pathogenic Asian H5N1 virus lineage. Copyright ?? 2007, American Society for Microbiology. All Rights Reserved.

  1. Retrospective space-time analysis of H5N1 Avian Influenza emergence in Thailand

    OpenAIRE

    Shanmugasundaram Jothiganesh; Gonzalez Jean-Paul; Souris Marc; Corvest Victoria; Kittayapong Pattamaporn

    2010-01-01

    Abstract Background The highly pathogenic avian influenza (HPAI) H5N1 virus remains a worldwide threat to human and animal health, while the mechanisms explaining its epizootic emergence and re-emergence in poultry are largely unknown. Data from Thailand, a country that experienced significant epidemics in poultry and has recorded suspicious cases of HPAI on a daily basis since 2004, are used here to study the process of emergence. A spatial approach is employed to describe all HPAI H5N1 viru...

  2. Basic Law of the Hong Kong Special Administrative Region (SAR) of China [4 April 1990].

    Science.gov (United States)

    1990-04-09

    On December 19, 1984, the Chinese and British Governments signed the joint declaration allowing the Peoples' Republic of China to resume sovereignty over Hong Kong effective July 1, 1997. To assure the prosperity and stability of Hong Kong, China will establish a Hong Kong Special Administrative Region allowing the socialist system and the policies practiced in Hong Kong to co-exist under the principle of "one country, two systems" as elaborated by the Chinese Government in the Sino-British joint declaration. Under the laws of China, the following Basic Law of the Hong Kong Special Administrative Region of the People's Republic of China is enacted, prescribing the systems to be practiced in the Hong Kong Special Administrative Region, necessary in order to assure implementation of the policies of China toward Hong Kong. The law covers: 1) General Principles, allowing the previous capitalist system to remain unchanged for 50 years, etc. 2) It establishes the relationship between the Central Authorities and the Hong Kong Special Administrative Region; e.g., China will defend Hong Kong, Hong Kong will possess independent judicial power. Chapter 3 defines the fundamental rights and duties of Hong Kong residents, and defines in chapter 4) the political structure that includes the Chief Executive, the Executive Authorities, the Legislature, the Judiciary, the District Organizations, and Public Servants. Chapter 5 contains information about the economy, public finance, monetary affairs, trade, industry, commerce, land leases, shipping, and civil aviation. Chapter 6 deals with education, science, culture, sports, religion, and labor and social services. Chapter 7 defines the responsibilities for external affairs. Chapter 8 specifies the interpretation and amendment of the Basic Law, ending with chapter 9 Supplementary Provisions, selection of the Chief Executive, formation of the Legislative Council, voting procedures, and the national laws to be applied in the Hong Kong

  3. Evaluation of information technology application in retail marketing in Hong Kong

    OpenAIRE

    Kwong, Tung-wing, Albert; 鄺東榮

    2014-01-01

    Hong Kong is renowned for its name of shopping paradise in the past several decades. It not only has the attractive street markets, but also has the different styles, themes and levels of shopping malls. Indeed, the retail industry of Hong Kong serves both visitors and Hong Kong local people as well. From the figures of Hong Kong Retail Management Association, it recorded HK$494,456 million dollars overall retail sale in 2013 and 267,703 person were employed as the workforce under retail as a...

  4. Remembering Student Activities in Hong Kong During the War of Resistance Against Japan(Ⅱ)

    Institute of Scientific and Technical Information of China (English)

    1997-01-01

    SINCE its foundation, the Hong Kong Student Association (HKSA) was productive, achieving much success and gaing public support."The students have been organized and shown the power of the collective. It is an ordinary thing on the Mainland, bu is a miracle in Hong Kong...," Shen Pao newspaper read. "The Hong Kong student movement seems promising for Hong Kong youth. The future is bright as the Chinese nation has such promising young people." In 1940, we ended the HKSA’s work. The female students’ work shifted to schools. Female student leaders went to

  5. A CROSS-SOCIETAL COMPARATIVE STUDY OF BEIJING AND HONG KONG CHILDRENS SELF-CONCEPT

    National Research Council Canada - National Science Library

    Hui, Anna; Lau, Sing; Li, Chun Sau; Tong, Toby; Zhang, Jie-Lian

    2006-01-01

    .... Beijing students scored much higher than Hong Kong students on the academic, social, physical and general domains and all the perspectives of parental appraisal, school appraisal, upward comparison...

  6. Avian influenza H5N1 viral and bird migration networks in Asia

    Science.gov (United States)

    Tian, Huaivu; Zhou, Sen; Dong, Lu; Van Boeckel, Thomas P.; Cui, Yujun; Newman, Scott H.; Takekawa, John Y.; Prosser, Diann J.; Xiao, Xiangming; Wu, Yarong; Cazelles, Bernard; Huang, Shanqian; Yang, Ruifu; Grenfell, Bryan T.; Xu, Bing

    2015-01-01

    The spatial spread of the highly pathogenic avian influenza virus H5N1 and its long-term persistence in Asia have resulted in avian influenza panzootics and enormous economic losses in the poultry sector. However, an understanding of the regional long-distance transmission and seasonal patterns of the virus is still lacking. In this study, we present a phylogeographic approach to reconstruct the viral migration network. We show that within each wild fowl migratory flyway, the timing of H5N1 outbreaks and viral migrations are closely associated, but little viral transmission was observed between the flyways. The bird migration network is shown to better reflect the observed viral gene sequence data than other networks and contributes to seasonal H5N1 epidemics in local regions and its large-scale transmission along flyways. These findings have potentially far-reaching consequences, improving our understanding of how bird migration drives the periodic reemergence of H5N1 in Asia.

  7. Evolution of highly pathogenic avian influenza H5N1 viruses in Egypt indicating progressive adaptation

    Science.gov (United States)

    Highly pathogenic avian influenza (HPAI) virus of the H5N1 subtype was first diagnosed in poultry in Egypt in 2006, and since then the disease became enzootic in poultry throughout the country affecting the poultry industry and village poultry as well as infecting humans. Vaccination has been used ...

  8. Gene expression responses to highly pathogenic avian influenza H5N1 virus infections in ducks

    Science.gov (United States)

    Differences in host response to infection with avian influenza (AI) viruses were investigated by identifying genes differentially expressed in tissues of infected ducks. Clear differences in pathogenicity were observed among ducks inoculated with five H5N1 HPAI viruses. Virus titers in tissues cor...

  9. The avian and mammalian host range of highly pathogenic avian H5N1 influenza.

    Science.gov (United States)

    Kaplan, Bryan S; Webby, Richard J

    2013-12-05

    Highly pathogenic H5N1 influenza viruses have been isolated from a number of avian and mammalian species. Despite intensive control measures the number of human and animal cases continues to increase. A more complete understanding of susceptible species and of contributing environmental and molecular factors is crucial if we are to slow the rate of new cases. H5N1 is currently endemic in domestic poultry in only a handful of countries with sporadic and unpredictable spread to other countries. Close contact of terrestrial bird or mammalian species with infected poultry/waterfowl or their biological products is the major route for interspecies transmission. Intra-species transmission of H5N1 in mammals, including humans, has taken place on a limited scale though it remains to be seen if this will change; recent laboratory studies suggest that it is indeed possible. Here we review the avian and mammalian species that are naturally susceptible to H5N1 infection and the molecular factors associated with its expanded host range.

  10. Pathogenesis of avian influenza A (H5N1) viruses in pigs

    Science.gov (United States)

    Background. Genetic reassortment of avian influenza H5N1 viruses with currently circulating human influenza A strains is one possibility that could lead to efficient human-to-human transmissibility. Domestic pigs which are susceptible to infection with both human and avian influenza A viruses are o...

  11. The pause on avian H5N1 influenza virus transmission research should be ended

    NARCIS (Netherlands)

    R.A.M. Fouchier (Ron); A. García-Sastre (Adolfo); Y. Kawaoka (Yoshihiro)

    2012-01-01

    textabstractA voluntary 60-day pause on avian H5N1 influenza virus transmission research was announced in January 2012 by the international community of influenza scientists engaged in this work to provide time to explain the benefits of such work and the risk mitigation measures in place. Subsequen

  12. Genetic insight of the H5N1 hemagglutinin cleavage site

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    The cleavability of the hemagglutinin (HA) plays a major role in virulence of avian influenza viruses. Detailed analyses of the cleavage sequences and their evolution would give insights into the high pathogenicity of the H5N1 virus. HA segments were visually identifiable in the cellular automata (CA) image, and a feature gene segment (FGS) was only found in H5N1 rather than any other subtype. This FGS is a 30-bp gene segment mainly consisting of 'A' and 'G'. When translated into amino acids the FGS converted into a sequence of mainly basic amino acids with positive charges. This feature amino acid segment (FAAS) was located in the cleavage site loop of HA which was potentially cleavable by various proteases. The 3D structure of H5N1 HA was reconstructed using homology modelling. It was found that the cleavage site loop was well exposed to potential proteases. The molecular surfaces were reconstructed to study how mutation and deletion of some amino acids in the FAAS affected the charge distribution. It was found that some mutations had severely changed the landscape of the charge distribution. Statistical analyses of FAAS were made with respect to when and where the H5N1 viruses were found. In 2005, there were less un-mutated FAAS than the other years according to temporal evolution, and more mutated FAAS appeared in China than other regions according to geographic distribution. These results are helpful for exploring the evolution of virus high pathogenicity.

  13. Bird migration and risk for H5N1 transmission into Qinghai Lake, China.

    Science.gov (United States)

    Cui, Peng; Hou, Yuansheng; Xing, Zhi; He, Yubang; Li, Tianxian; Guo, Shan; Luo, Ze; Yan, Baoping; Yin, Zuohua; Lei, Fumin

    2011-05-01

    The highly pathogenic avian influenza H5N1 virus still cause devastating effects to humans, agricultural poultry flocks, and wild birds. Wild birds are also detected to carry H5N1 over long distances and are able to introduce it into new areas during migration. In this article, our objective is to provide lists of bird species potentially involved in the introduction of highly pathogenic avian influenza H5N1 in Qinghai Lake, which is an important breeding and stopover site for aquatic birds along the Central Asian Flyway. Bird species were classified according to the following behavioral and ecological factors: migratory status, abundance, degree of mixing species and gregariousness, and the prevalence rate of H5N1 virus. Most of the high-risk species were from the family Anatidae, order Anseriformes (9/14 in spring, 11/15 in fall). We also estimated the relative risk of bird species involved by using a semi-quantitative method; species from family Anatidae accounted for over 39% and over 91% of the total risk at spring and fall migration periods, respectively. Results also show the relative risk for each bird aggregating site in helping to identify high-risk areas. This work may also be instructive and meaningful to the avian influenza surveillance in the breeding, stopover, and wintering sites besides Qinghai Lake along the Central Asian Flyway.

  14. Hemagglutinin from the H5N1 virus activates Janus kinase 3 to dysregulate innate immunity.

    Directory of Open Access Journals (Sweden)

    Wei Xu

    Full Text Available Highly pathogenic avian influenza viruses (HPAIVs cause severe disease in humans. There are no effective vaccines or antiviral therapies currently available to control fatal outbreaks due in part to the lack of understanding of virus-mediated immunopathology. In our study, we used hemagglutinin (HA of H5N1 virus to investigate the related signaling pathways and their relationship to dysregulated innate immune reaction. We found the HA of H5N1 avian influenza triggered an abnormal innate immune signalling in the pulmonary epithelial cells, through an unusual process involving activation of Janus kinase 3 (JAK3 that is exclusively associated with γc chain and is essential for signaling via all γc cytokine receptors. By using a selective JAK3 inhibitor and JAK3 knockout mice, we have, for the first time, demonstrated the ability to target active JAK3 to counteract injury to the lungs and protect immunocytes from acute hypercytokinemia -induced destruction following the challenge of H5N1 HA in vitro and in vivo. On the basis of the present data, it appears that the efficacy of selective JAK3 inhibition is likely based on its ability to block multiple cytokines and protect against a superinflammatory response to pathogen-associated molecular patterns (PAMPs attack. Our findings highlight the potential value of selective JAK3 inhibitor in treating the fatal immunopathology caused by H5N1 challenge.

  15. Molecular characteristic and pathogenicity of Indonesian H5N1 clade 2.3.2 viruses

    Directory of Open Access Journals (Sweden)

    Dharmayanti NLPI

    2013-06-01

    Full Text Available The outbreak of disease in late 2012 in Indonesia caused high duck mortality. The agent of the disease was identified as H5N1 clade 2.3.2. The disease caused economic loss to the Indonesian duck farmer. The clade 2.3.2 of H5N1 virus has not previously been identified, so this study was conducted to characterize 4 of H5N1 clade 2.3.2 viruses by DNA sequencing in eight genes segment virus namely HA, NA, NS, M, PB1, PB2, PA and NP. The pathogenicity test of clade 2.3.2 viruses in ducks was compared to clade 2.1.3 viruses which predominat circulating in Indonesia. Results of phylogenetic tree analysis showed that the four of clade 2.3.2 viruses isolated in 2012 was the new introduced virus from abroad. Further analysis showed eight genes were in one group with the clade 2.3.2 viruses, especially those from VietNam and did not belong to Indonesia viruses group. The pathogenicity test in ducks showed that virus H5N1 clade 2.3.2 and clade 2.1.3 have similar clinical symptoms and pathogenicity and cause death in 75% of ducks on days 3-6 after infection.

  16. Ecological determinants of highly pathogenic avian influenza (H5N1) outbreaks in Bangladesh

    DEFF Research Database (Denmark)

    Ahmed, Syed Sayeem Uddin; Ersbøll, Annette Kjær; Biswas, Paritosh K.

    2012-01-01

    Background: The agro-ecology and poultry husbandry of the south Asian and south-east Asian countries share common features, however, with noticeable differences. Hence, the ecological determinants associated with risk of highly pathogenic avian influenza (HPAI-H5N1) outbreaks are expected to diff...

  17. Influenza A H5N1 and HIV co-infection: case report

    Directory of Open Access Journals (Sweden)

    Simmons Cameron

    2010-06-01

    Full Text Available Abstract Background The role of adaptive immunity in severe influenza is poorly understood. The occurrence of influenza A/H5N1 in a patient with HIV provided a rare opportunity to investigate this. Case Presentation A 30-year-old male was admitted on day 4 of influenza-like-illness with tachycardia, tachypnea, hypoxemia and bilateral pulmonary infiltrates. Influenza A/H5N1 and HIV tests were positive and the patient was treated with Oseltamivir and broad-spectrum antibiotics. Initially his condition improved coinciding with virus clearance by day 6. He clinically deteriorated as of day 10 with fever recrudescence and increasing neutrophil counts and died on day 16. His admission CD4 count was 100/μl and decreased until virus was cleared. CD8 T cells shifted to a CD27+CD28- phenotype. Plasma chemokine and cytokine levels were similar to those found previously in fatal H5N1. Conclusions The course of H5N1 infection was not notably different from other cases. Virus was cleared despite profound CD4 T cell depletion and aberrant CD8 T cell activation but this may have increased susceptibility to a fatal secondary infection.

  18. Highly pathogenic avian influenza H5N1 in Mainland China

    NARCIS (Netherlands)

    X.-L. Li (Xin-Lou); K. Liu (Kun); H.-W. Yao (Hong-Wu); Y. Sun (Ye); W.-J. Chen (Wan-Jun); R.-X. Sun (Ruo-Xi); S.J. de Vlas (Sake); L.Q. Fang; W. Cao (W.)

    2015-01-01

    textabstractHighly pathogenic avian influenza (HPAI) H5N1 has posed a significant threat to both humans and birds, and it has spanned large geographic areas and various ecological systems throughout Asia, Europe and Africa, but especially in mainland China. Great efforts in control and prevention of

  19. Influenza viruses and the evolution of avian influenza virus H5N1.

    Science.gov (United States)

    Skeik, Nedaa; Jabr, Fadi I

    2008-05-01

    Although small in size and simple in structure, influenza viruses are sophisticated organisms with highly mutagenic genomes and wide antigenic diversity. They are species-specific organisms. Mutation and reassortment have resulted in newer viruses such as H5N1, with new resistance against anti-viral medications, and this might lead to the emergence of a fully transmissible strain, as occurred in the 1957 and 1968 pandemics. Influenza viruses are no longer just a cause of self-limited upper respiratory tract infections; the H5N1 avian influenza virus can cause severe human infection with a mortality rate exceeding 50%. The case death rate of H5N1 avian influenza infection is 20 times higher than that of the 1918 infection (50% versus 2.5%), which killed 675000 people in the USA and almost 40 million people worldwide. While the clock is still ticking towards what seems to be inevitable pandemic influenza, on April 17, 2007 the U.S. Food and Drug Administration (FDA) approved the first vaccine against the avian influenza virus H5N1 for humans at high risk. However, more research is needed to develop a more effective and affordable vaccine that can be given at lower doses.

  20. Evolution and adaptation of hemagglutinin gene of human H5N1 influenza virus.

    Science.gov (United States)

    Wei, Kaifa; Chen, Yanfeng; Chen, Juan; Wu, Lingjuan; Xie, Daoxin

    2012-06-01

    The H5N1 HPAI virus has brought heavy loss to poultry industry. Although, there exists limited human-to-human transmission, it poses potential serious risks to public health. HA is responsible for receptor-binding and membrane-fusion and contains the host receptor-binding sites and major epitopes for neutralizing antibodies. To investigate molecular adaption of HPAI H5N1 viruses, we performed a phylogenetic analysis of HA sequences with 240 HPAI virus strains isolated from human. The topology of the tree reveals overall clustering of strains in four major clusters based on geographic location, and shows antigenic diversity of HA of human H5N1 isolates co-circulating in Asia, Africa, and Europe. The four clusters possess distinct features within the cleavage site and glycosylation sites, respectively. We identified six sites apparently evolving under positive selection, five of which persist in the population. Three positively selected sites are found to be located either within or flanking the receptor-binding sites, suggesting that selection at these sites may increase the affinity to human-type receptor. Furthermore, some sites are also associated with glycosylation and antigenic changes. In addition, two sites are found to be selected differentially in the two clusters. The analyses provide us deep insight into the adaptive evolution of human H5N1 viruses, show us several candidate mutations that could cause a pandemic, and suggest that efficiency measures should be taken to deal with potential risks.

  1. Knowledge discovery from mining the association between H5N1 outbreaks and environmental factors

    NARCIS (Netherlands)

    Si, Y.; Wang, T.; Skidmore, A.K.; Prins, H.H.T.

    2010-01-01

    The global spread of highly pathogenic avian influenza H5N1 in poultry, wild birds and humans, poses a significant panzootic threat and a serious public health risk. An efficient surveillance and disease control system requires a deep understanding of their spread mechanisms, including environmental

  2. Avian Influenza Virus A (H5N1), Detected through Routine Surveillance, in Child, Bangladesh

    Science.gov (United States)

    Alamgir, A.S.M.; Sultana, Rebecca; Islam, M. Saiful; Rahman, Mustafizur; Fry, Alicia M.; Shu, Bo; Lindstrom, Stephen; Nahar, Kamrun; Goswami, Doli; Haider, M. Sabbir; Nahar, Sharifun; Butler, Ebonee; Hancock, Kathy; Donis, Ruben O.; Davis, Charles T.; Zaman, Rashid Uz; Luby, Stephen P.; Uyeki, Timothy M.; Rahman, Mahmudur

    2009-01-01

    We identified avian influenza virus A (H5N1) infection in a child in Bangladesh in 2008 by routine influenza surveillance. The virus was of the same clade and phylogenetic subgroup as that circulating among poultry during the period. This case illustrates the value of routine surveillance for detection of novel influenza virus. PMID:19751601

  3. Environmental factors contributing to the spread of H5N1 avian influenza in mainland China

    NARCIS (Netherlands)

    L.Q. Fang; S.J. de Vlas (Sake); S. Liang (Song); C.W.N. Looman (Caspar); P. Gong (Peng); B. Xu (Bing); L. Yan (Lei); H. Yang (Honghui); J.H. Richardus (Jan Hendrik); W.C. Cao (Wu Chun)

    2008-01-01

    textabstractBackground: Since late 2003, highly pathogenic avian influenza (HPAI) outbreaks caused by infection with H5N1 virus has led to the deaths of millions of poultry and more than 10 thousands of wild birds, and as of 18-March 2008, at least 373 laboratory-confirmed human infections with 236

  4. Rapid detection of the avian influenza virus H5N1 subtype in Egypt ...

    African Journals Online (AJOL)

    Rapid detection of the avian influenza virus H5N1 subtype in Egypt. ... Effective diagnosis and control management are needed to control the disease. ... rabbit serum, which secrete immunoglobulin G (IgG) was served as the detector antibody ...

  5. Spatial and temporal patterns of global H5N1 outbreaks

    CSIR Research Space (South Africa)

    Si, YL

    2008-07-01

    Full Text Available The global spread of highly pathogenic avian influenza (H5N1) in wild birds and poultry is considered a significant pandemic threat. Furthermore, human infections resulting from direct contact with infected birds/ poultry pose a serious public...

  6. Self-reported Stress Problems among Teachers in Hong Kong

    Science.gov (United States)

    Chan, Alan H. S.; Chen, K.; Chong, Elaine Y. L.

    2010-10-01

    The present study was developed to comprehensively investigate the occupational health problems among teachers of primary and secondary schools in Hong Kong. A random sample of 1,710 respondents was generated from the database of Hong Kong Professional Teachers' Union (HKPTU) members. A self-administrated questionnaire was designed and sent by mail to the teachers of primary and secondary schools in HK. The results indicated that comparing with one year and five years ago, 91.6% and 97.3% of the responding teachers reported an increase of perceived stress level, respectively. Heavy workload and time pressure, education reforms, external school review, pursuing further education, and managing students' behaviour and learning were the most frequently reported sources of work stress. The four most frequently reported stress management activities were sleeping, talking to neighbors and friends, self-relaxing, and watching television, while the least frequently reported activity was doing more exercises or sports.

  7. Characteristics of urban ozone level in Hong kong

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The long term trend of ozone level in Hong Kong has been investigated. One of the characteristics of ozone level in Hong Kong is the existence of autumn maximum and summer minimum. Observations of the diurnal variation of ozone level have been made in different area categories. There are early morning peak and afternoon peak occurred in the diurnal variation, which are different from some metropolitans where only an afternoon peak is observed. A negative correlation coefficient was found between monthly ozone level with nitric oxide level. On the contrary, there is a positive correlation between ozone and nitrogen dioxide. The positive correlation coefficient between nitric oxide and nitrogen dioxide shows that the total amount of nitric oxide emitted from a series of moving and fixed sources greatly exceeded the stoichiometric amount of ozone formed from chemical reactions of precursors and long distance transportation.

  8. Stock Market Manipulation on the Hong Kong Stock Exchange

    Directory of Open Access Journals (Sweden)

    Dionigi Gerace

    2014-10-01

    Full Text Available This study is the first to empirically examine stock market manipulation on the Hong Kong Stock Exchange. The dataset contains 40 cases of market manipulation from 1996 to 2009 that were successfully prosecuted by the Hong Kong Securities & Futures Commission. Manipulation is found to negatively impact market efficiency measures such as the bid-ask spread and volatility. Markets appear incapable of efficiently responding to the presence of manipulators and are characterised by information asymmetry. Manipulators were successfully able to raise prices and exit the market. This finding contradicts views that trade-based manipulation is entirely unprofitable and self-deterring. The victimisation of information-seeking investors and the market as a whole provides a strong rationale for all jurisdictions, including Australia, to have effective laws that prohibit manipulation and for robust enforcement of those laws to further deter market manipulation.

  9. H5N1 surveillance in migratory birds in Java, Indonesia.

    Science.gov (United States)

    Stoops, Arthur C; Barbara, Katie A; Indrawan, Mochamad; Ibrahim, Ima N; Petrus, Wicaksana B; Wijaya, Susan; Farzeli, Arik; Antonjaya, Ungke; Sin, Lim W; Hidayatullah, N; Kristanto, Ige; Tampubolon, A M; Purnama, S; Supriatna, Adam; Burgess, Timothy H; Williams, Maya; Putnam, Shannon D; Tobias, Steve; Blair, Patrick J

    2009-12-01

    We sought to elucidate the role of migratory birds in transmission of H5N1 in an enzoonotic area. Resident, captive, and migratory birds were sampled at five sites in Java, Indonesia. Mist nets were used to trap birds. Birds were identified to species. RNA was extracted from swabs and reverse transcriptase polymerase chain reaction (RT-PCR) conducted for the HA and M genes of H5N1. Antibodies were detected by enzyme-linked immunosorbent assay and hemagglutination inhibition test. Between October 2006 and September 2007, a total of 4,067 captive, resident, and migratory birds comprising 98 species in 23 genera were sampled. The most commonly collected birds were the common sandpiper (6% of total), striated heron (3%), and the domestic chicken (14%). The overall prevalence of H5N1 antibodies was 5.3%. A significantly higher percentage of captive birds (16.1%) showed antibody evidence of H5N1 exposure when compared to migratory or resident birds. The greatest number of seropositive birds in each category were Muschovy duck (captive), striated heron (resident), and the Pacific golden plover (migratory). Seven apparently well captive birds yielded molecular evidence of H5N1 infection. Following amplification, the HA, NA, and M genes were analyzed. Phylogenetic analysis of the HA gene showed that the isolates were 97% similar to EU124153.1 A/chicken/West Java/Garut May 2006, an isolate obtained in a similar region of West Java. While no known markers of neuraminidase inhibitor resistance were found within the NA gene, M segment analysis revealed the V27A mutation known to confer resistance to adamantanes. Our results demonstrate moderate serologic evidence of H5N1 infection in captive birds, sampled in five sites in Java, Indonesia, but only occasional infection in resident and migratory birds. These data imply that in an enzoonotic region of Indonesia the role of migratory birds in transmission of H5N1 is limited.

  10. Highly Pathogenic Avian Influenza H5N1 in Mainland China

    Directory of Open Access Journals (Sweden)

    Xin-Lou Li

    2015-05-01

    Full Text Available Highly pathogenic avian influenza (HPAI H5N1 has posed a significant threat to both humans and birds, and it has spanned large geographic areas and various ecological systems throughout Asia, Europe and Africa, but especially in mainland China. Great efforts in control and prevention of the disease, including universal vaccination campaigns in poultry and active serological and virological surveillance, have been undertaken in mainland China since the beginning of 2006. In this study, we aim to characterize the spatial and temporal patterns of HPAI H5N1, and identify influencing factors favoring the occurrence of HPAI H5N1 outbreaks in poultry in mainland China. Our study shows that HPAI H5N1 outbreaks took place sporadically after vaccination campaigns in poultry, and mostly occurred in the cold season. The positive tests in routine virological surveillance of HPAI H5N1 virus in chicken, duck, goose as well as environmental samples were mapped to display the potential risk distribution of the virus. Southern China had a higher positive rate than northern China, and positive samples were mostly detected from chickens in the north, while the majority were from duck in the south, and a negative correlation with monthly vaccination rates in domestic poultry was found (R = −0.19, p value = 0.005. Multivariate panel logistic regression identified vaccination rate, interaction between distance to the nearest city and national highway, interaction between distance to the nearest lake and wetland, and density of human population, as well as the autoregressive term in space and time as independent risk factors in the occurrence of HPAI H5N1 outbreaks, based on which a predicted risk map of the disease was derived. Our findings could provide new understanding of the distribution and transmission of HPAI H5N1 in mainland China and could be used to inform targeted surveillance and control efforts in both human and poultry populations to reduce the risk of

  11. Genetic drift evolution under vaccination pressure among H5N1 Egyptian isolates

    Directory of Open Access Journals (Sweden)

    Afifi Manal A

    2011-06-01

    Full Text Available Background The highly pathogenic H5N1 is a major avian pathogen that intensively affects the poultry industry in Egypt even in spite of the adoption of vaccination strategy. Antigenic drift is among the strategies the influenza virus uses to escape the immune system that might develop due to the pressure of extensive vaccination. H5N1 mutates in an intensified manner and is considered a potential candidate for the possible next pandemic with all the catastrophic consequences such an eventuality will entail. Methods H5N1 was isolated from the pooled organ samples of four different affected flocks in specific pathogen free embryonated chicken eggs (SPF-ECE. A reverse transcriptase polymerase chain reaction (RT-PCR was performed to the haemagglutingin and neuraminidase. Sequencing of the full length haemagglutingin was performed. Sequence analyses of the isolated strains were performed and compared to all available H5N1 from Egyptian human and avian strains in the flu database. Changes in the different amino acid that may be related to virus virulence, receptor affinity and epitope configuration were assigned and matched with all available Egyptian strains in the flu database. Results One out of the four strains was found to be related to the B2 Egyptian lineage, 2 were related to A1 lineage and the 4th was related to A2 lineage. Comparing data obtained from the current study by other available Egyptian H5N1 sequences remarkably demonstrates that amino acid changes in the immune escape variants are remarkably restricted to a limited number of locations on the HA molecule during antigenic drift. Molecular diversity in the HA gene, in relevance to different epitopes, were not found to follow a regular trend, suggesting abrupt cumulative sequence mutations. However a number of amino acids were found to be subjected to high mutation pressure. Conclusion The current data provides a comprehensive view of HA gene evolution among H5N1 subtype viruses in

  12. The Use of Management Contracts for Construction in Hong Kong

    Institute of Scientific and Technical Information of China (English)

    Dr. S.L. Tang

    2002-01-01

    A traditional construction contract requires all detail design works to be completed before tendering and subsequentconstruction works can commence, and therefore requires a longer time for project completion. This paper describes ahence reduce project duration. There are advantages in management contracting, but there are disadvantages too. They arediscussed in detail in this paper. Two management contracts executed in Hong Kong are used as case studies to illustrate thesaid advantages and disadvantages. Conclusion is then made and possible further research work is also suggested.

  13. SARS Transmission among Hospital Workers in Hong Kong

    OpenAIRE

    Lau, Joseph T F; Fung, Kitty S.; Wong, Tze Wai; Kim, Jean H; Wong, Eric; Chung, Sydney; Ho, Deborah; Chan, Louis Y; Lui, S F; Cheng, Augustine

    2004-01-01

    Despite infection control measures, breakthrough transmission of severe acute respiratory syndrome (SARS) occurred for many hospital workers in Hong Kong. We conducted a case-control study of 72 hospital workers with SARS and 144 matched controls. Inconsistent use of goggles, gowns, gloves, and caps was associated with a higher risk for SARS infection (unadjusted odds ratio 2.42 to 20.54, p < 0.05). The likelihood of SARS infection was strongly associated with the amount of personal protectio...

  14. The transferability of housing voucher system in Hong Kong

    OpenAIRE

    Tang, Yiu-kei; 鄧耀基

    2013-01-01

    This dissertation is about the use of in-cash housing subsidy, in the form of housing voucher, to deliver housing welfare in Hong Kong. This type of subsidy is currently the major type of housing assistance implemented in the United States since 1970s for improving the deteriorating public housing stock as well as the concentrated poverty and racial segregated neighbourhoods developed in the public housing projects. As a foreign policy, the research has taken the academic approach of policy t...

  15. Recent Research of Power Electronics and Drives in Hong Kong

    Institute of Scientific and Technical Information of China (English)

    K.W.E.Cheng; N.C.Cheung

    2004-01-01

    The research in Power Electronics and Dives at The Hong Kong Polytechnic University has been undertaking for many years. Recently, a Power Electronics Research Centre (PERC) has been developed that is contributed towards the research anddevelopment in the area. It encompasses the high frequency power supplies, chaos and bifurcation, soft-switching power converters, electrical machines, high precision motion control, traction and traffic control,alternative energy and electrical building services.

  16. Physical Hydrography and Algal Bloom Transport in Hong Kong Waters

    Institute of Scientific and Technical Information of China (English)

    KUANG Cui-ping; LEE Joseph H.W.

    2005-01-01

    In sub-tropical coastal waters around Hong Kong, algal blooms and red tides are usually first sighted in the Mirs Bay, in the eastern waters of Hong Kong. A calibrated three-dimensional hydrodynamic model for the Pearl River Estuary (Delft3D) has been applied to the study of the physical hydrography of Hong Kong waters and its relationship with algal bloom transport patterns in the dry and wet seasons. The general 3D hydrodynamic circulation and salinity structure in the partially-mixed estuary are presented. Extensive numerical surface drogue tracking experiments are performed for algal blooms that are initiated in the Mirs Bay under different seasonal, wind and tidal conditions. The probability of bloom impact on the Victoria Harbour and nearby urban coastal waters is estimated. The computations show that: I) In the wet season (May~August), algal blooms initiated in the Mirs Bay will move in a clockwise direction out of the bay, and be transported away from Hong Kong due to SW monsoon winds which drive the SW to NE coastal current; ii) In the dry season (November~April), algal blooms initiated in the northeast Mirs Bay will move in an anti-clockwise direction and be carried away into southern waters due to the NE to SW coastal current driven by the NE monsoon winds; the bloom typically flows past the east edge of the Victoria Harbour and nearby waters. Finally, the role of hydrodynamic transport in an important episodic event - the spring 1998 massive red tide - is quantitatively examined. It is shown that the strong NE to E wind during late March to early April, coupled with the diurnal tide at the beginning of April, significantly increased the probability of bloom transport into the Port Shelter and East Lamma Channel, resulting in the massive fish kill. The results provide a basis for risk assessment of harmful algal bloom (HAB) impact on urban coastal waters around the Victoria Habour.

  17. Highly pathogenic influenza A(H5N1 virus survival in complex artificial aquatic biotopes.

    Directory of Open Access Journals (Sweden)

    Viseth Srey Horm

    Full Text Available BACKGROUND: Very little is known regarding the persistence of Highly Pathogenic Avian Influenza (HPAI H5N1 viruses in aquatic environments in tropical countries, although environmental materials have been suggested to play a role as reservoirs and sources of transmission for H5N1 viruses. METHODOLOGY/PRINCIPAL FINDINGS: The survival of HPAI H5N1 viruses in experimental aquatic biotopes (water, mud, aquatic flora and fauna relevant to field conditions in Cambodia was investigated. Artificial aquatic biotopes, including simple ones containing only mud and water, and complex biotopes involving the presence of aquatic flora and fauna, were set up. They were experimentally contaminated with H5N1 virus. The persistence of HPAI H5N1 virus (local avian and human isolates was determined by virus isolation in embryonated chicken eggs and by real-time reverse-polymerase chain reaction. Persistence of infectious virus did not exceed 4 days, and was only identified in rain water. No infectious virus particles were detected in pond and lake water or mud even when high inoculum doses were used. However, viral RNA persisted up to 20 days in rain water and 7 days in pond or lake water. Viral RNA was also detected in mud samples, up to 14 days post-contamination in several cases. Infectious virus and viral RNA was detected in few cases in the aquatic fauna and flora, especially in bivalves and labyrinth fish, although these organisms seemed to be mostly passive carriers of the virus rather than host allowing virus replication. CONCLUSIONS/SIGNIFICANCE: Although several factors for the survival and persistence of HPAI viruses in the environment are still to be elucidated, and are particularly hard to control in laboratory conditions, our results, along with previous data, support the idea that environmental surveillance is of major relevance for avian influenza control programs.

  18. Epitope mapping of neutralizing monoclonal antibody in avian influenza A H5N1 virus hemagglutinin.

    Science.gov (United States)

    Ohkura, Takashi; Kikuchi, Yuji; Kono, Naoko; Itamura, Shigeyuki; Komase, Katsuhiro; Momose, Fumitaka; Morikawa, Yuko

    2012-02-03

    The global spread of highly pathogenic avian influenza A H5N1 viruses raises concerns about more widespread infection in the human population. Pre-pandemic vaccine for H5N1 clade 1 influenza viruses has been produced from the A/Viet Nam/1194/2004 strain (VN1194), but recent prevalent avian H5N1 viruses have been categorized into the clade 2 strains, which are antigenically distinct from the pre-pandemic vaccine. To understand the antigenicity of H5N1 hemagglutinin (HA), we produced a neutralizing monoclonal antibody (mAb12-1G6) using the pre-pandemic vaccine. Analysis with chimeric and point mutant HAs revealed that mAb12-1G6 bound to the loop (amino acid positions 140-145) corresponding to an antigenic site A in the H3 HA. mAb12-1G6 failed to bind to the mutant VN1194 HA when only 3 residues were substituted with the corresponding residues of the clade 2.1.3.2 A/Indonesia/5/05 strain (amino acid substitutions at positions Q142L, K144S, and S145P), suggesting that these amino acids are critical for binding of mAb12-1G6. Escape mutants of VN1194 selected with mAb12-1G6 carried a S145P mutation. Interestingly, mAb12-1G6 cross-neutralized clade 1 and clade 2.2.1 but not clade 2.1.3.2 or clade 2.3.4 of the H5N1 virus. We discuss the cross-reactivity, based on the amino acid sequence of the epitope.

  19. Immunostimulatory motifs enhance antiviral siRNAs targeting highly pathogenic avian influenza H5N1.

    Directory of Open Access Journals (Sweden)

    Cameron R Stewart

    Full Text Available Highly pathogenic avian influenza (HPAI H5N1 virus is endemic in many regions around the world and remains a significant pandemic threat. To date H5N1 has claimed almost 300 human lives worldwide, with a mortality rate of 60% and has caused the death or culling of hundreds of millions of poultry since its initial outbreak in 1997. We have designed multi-functional RNA interference (RNAi-based therapeutics targeting H5N1 that degrade viral mRNA via the RNAi pathway while at the same time augmenting the host antiviral response by inducing host type I interferon (IFN production. Moreover, we have identified two factors critical for maximising the immunostimulatory properties of short interfering (siRNAs in chicken cells (i mode of synthesis and (ii nucleoside sequence to augment the response to virus. The 5-bp nucleoside sequence 5'-UGUGU-3' is a key determinant in inducing high levels of expression of IFN-α, -β, -λ and interleukin 1-β in chicken cells. Positioning of this 5'-UGUGU-3' motif at the 5'-end of the sense strand of siRNAs, but not the 3'-end, resulted in a rapid and enhanced induction of type I IFN. An anti-H5N1 avian influenza siRNA directed against the PB1 gene (PB1-2257 tagged with 5'-UGUGU-3' induced type I IFN earlier and to a greater extent compared to a non-tagged PB1-2257. Tested against H5N1 in vitro, the tagged PB1-2257 was more effective than non-tagged PB1-2257. These data demonstrate the ability of an immunostimulatory motif to improve the performance of an RNAi-based antiviral, a finding that may influence the design of future RNAi-based anti-influenza therapeutics.

  20. Intersubtype Reassortments of H5N1 Highly Pathogenic Avian Influenza Viruses Isolated from Quail.

    Science.gov (United States)

    Nguyen, Tinh Huu; Than, Van Thai; Thanh, Hien Dang; Hung, Vu-Khac; Nguyen, Duc Tan; Kim, Wonyong

    2016-01-01

    H5N1 highly pathogenic avian influenza (HPAI) viruses are considered a threat to national animal industries, causing production losses and high mortality in domestic poultry. In recent years, quail has become a popular terrestrial poultry species raised for production of meat and eggs in Asia. In this study, to better understand the roles of quail in H5N1 viral evolution, two H5N1-positive samples, designated A/quail/Vietnam/CVVI-49/2010 (CVVI-49/2010) and A/quail/Vietnam/CVVI-50/2014 (CVVI-50/2014), were isolated from quail during H5N1 outbreaks in Vietnam, and their whole genome were analyzed. The phylogenetic analysis reveals new evolutionary variation in the worldwide H5N1 viruses. The quail HA genes were clustered into clades 1.1.1 (CVVI-49/2010) and clade 2.3.2.1c (CVVI-50/2014), which may have evolved from viruses circulating from chickens and/or ducks in Cambodia, mainland of China, Taiwan, Indonesia, and South Korea in recent years. Interestingly, the M2 gene of the CVVI-49/2010 strain contained amino acid substitutions at position 26L-I and 31S-N that are related to amantadine-resistance. In particular, the CVVI-50/2014 strain revealed evidence of multiple intersubtype reassortment events between virus clades 2.3.2.1c, 2.3.2.1b, and 2.3.2.1a. Data from this study supports the possible role of quail as an important intermediate host in avian influenza virus evolution. Therefore, additional surveillance is needed to monitor these HPAI viruses both serologically and virologically in quail.

  1. EVOLUTION AND DEVELOPMENT OF GUANGZHOU-HONG KONG CORRIDOR

    Institute of Scientific and Technical Information of China (English)

    LI Ping; CAO Xiao-shu

    2005-01-01

    With its rapid development in the past two decades, the Pearl River Delta has become one of the most developed regions in China. During this period, an important corridor between Hong Kong and Guangzhou has emerged and shaped the spatial structure of the region. The growth of this region has been greatly marched with the twin poles of Guangzhou and Hong Kong, and the economic and social development h. as taken place in a corridor between these two metropolises. This paper provides an analysis of the significance of this corridor in terms of its infrastructure, population, land use, and economic development. Massive infrastructure construction in the corridor has played an important role in its development. The corridor has high-frequent transport, and each transport mode has contributed in a different way to the process of development of the corridor, With high land use intensity and high population density, it is developing the characteristics of a megalopolis. As a pathway of connection between Guangzhou and Hong Kong, the corridor includes not only physical infrastructure, such as roads, railways and airports, but also logistics operations, human resources, information and capital, which plays important roles in accelerating business development. It demonstrates how this Main Street has become one of the most important factors in regional development.

  2. Review of vector-borne diseases in Hong Kong.

    Science.gov (United States)

    Ma, Siu-keung Edmond; Wong, Wang Christine; Leung, Chi-wah Ryan; Lai, Sik-to Thomas; Lo, Yee-chi Janice; Wong, Kai-hay Howard; Chan, Man-chung; Que, Tak-lun; Chow, Ka-wai Mary; Yuen, Ming-chi; Lau, Tin-wai Winnie; Simon, John

    2011-05-01

    The epidemiology of vector-borne diseases in Hong Kong has changed over the past decade but still poses a significant public health risk. We provided a comprehensive review of the epidemiological information and analysed the trends of major vector-borne diseases, including the vector situation in Hong Kong. The incidence of malaria has dropped dramatically in the past few decades and is now mainly an imported disease acquired from malaria endemic countries. Locally acquired dengue fever occurred in 2002 and 2003, and thereafter all cases were imported, mainly from Southeast Asia areas. Only a few local cases of Japanese encephalitis were reported in the past decade. In contrast, there is a notable increase in scrub typhus and spotted fever cases. The emergence of chikungunya fever in Asia and Indian Ocean countries also resulted in importation of human cases. Given the heavy traffic between this international city and other parts of the world, as well as the presence of vectors in this densely populated area, vigilance should be maintained against these infections. Comprehensive public health measures encompassing disease surveillance, vector surveillance and control measures with support from all sectors of the community are required to combat the old and newly emerging vector-borne diseases in Hong Kong.

  3. Performance selection for Thoroughbreds racing in Hong Kong.

    Science.gov (United States)

    Velie, B D; Hamilton, N A; Wade, C M

    2015-01-01

    Different indicators of racing performance are commonly used in the racing industry to assess the genetic superiority of racing Thoroughbreds. However, how well these indicators predict the performance of future progeny or siblings varies depending on the population and circumstances in which the indicators were recorded or achieved. To identify heritable indicators of racing performance for horses racing in Hong Kong. Heritability analysis of racing performance traits. Performance data on the population of Thoroughbreds racing in Hong Kong between 3 September 2000 and 12 March 2011 (n = 4947) were acquired and used to estimate the heritabilities and probability values of fixed effects and covariates for a range of racing performance traits. Heritabilities for all performance traits were estimated using a single trait animal model. Each model included, as a minimum, the effects of sex, region of origin and trainer. Heritability estimates for traits relating to finish position ranged from 0.01 to 0.06. Average handicap weight had a heritability of 0.07 ± 0.03. The effects of sex (fixed) and trainer (random) were significant (Pracing performance can be reliably used to predict the performance of the individual's progeny or siblings. However, despite Hong Kong's controlled racing environment, these indicators appear to be no more heritable than in other less controlled racing environments. © 2014 EVJ Ltd.

  4. Understanding the Underwater Behaviour of Scuba Divers in Hong Kong

    Science.gov (United States)

    Chung, Shan-shan; Au, Alfred; Qiu, Jian-Wen

    2013-04-01

    Diving-related activities may constitute a major threat to coral reefs. This study aimed to quantify the impact of diving in Hong Kong on hard corals and understand how socio-economic characteristics and experience level of divers influence diver-inflicted damage. We recorded and analysed the underwater behaviour of 81 recreational divers. On average, a diver was in contact with marine biota 14.7 times with about 40 % of contacts involved corals and 38 % were damaging contacts with corals or other biota in a single dive. The most harm-inflicting groups included inexperienced and camera-carrying divers. Although Hong Kong divers did not make many damaging contacts with corals, there is still an imminent need to determine the scale of damage from diving activities on the marine ecosystem given the rapid development of marine-based tourism and the limited coral-inhabited areas in Hong Kong where the marine environment is already under stress from anthropogenic activities.

  5. Understanding the underwater behaviour of scuba divers in Hong Kong.

    Science.gov (United States)

    Chung, Shan-Shan; Au, Alfred; Qiu, Jian-Wen

    2013-04-01

    Diving-related activities may constitute a major threat to coral reefs. This study aimed to quantify the impact of diving in Hong Kong on hard corals and understand how socio-economic characteristics and experience level of divers influence diver-inflicted damage. We recorded and analysed the underwater behaviour of 81 recreational divers. On average, a diver was in contact with marine biota 14.7 times with about 40% of contacts involved corals and 38% were damaging contacts with corals or other biota in a single dive. The most harm-inflicting groups included inexperienced and camera-carrying divers. Although Hong Kong divers did not make many damaging contacts with corals, there is still an imminent need to determine the scale of damage from diving activities on the marine ecosystem given the rapid development of marine-based tourism and the limited coral-inhabited areas in Hong Kong where the marine environment is already under stress from anthropogenic activities.

  6. Hong Kong Consensus Recommendations on the Management of Hepatocellular Carcinoma

    Science.gov (United States)

    Poon, Ronnie Tung-Ping; Cheung, Tom Tan-To; Kwok, Philip Chong-Hei; Lee, Ann-Shing; Li, Tat-Wing; Loke, Kwok-Loon; Chan, Stephen Lam; Cheung, Moon-Tong; Lai, Tak-Wing; Cheung, Chin-Cheung; Cheung, Foon-Yiu; Loo, Ching-Kong; But, Yiu-Kuen; Hsu, Shing-Jih; Yu, Simon Chun-Ho; Yau, Thomas

    2015-01-01

    Background Hepatocellular carcinoma (HCC) is particularly prevalent in Hong Kong because of the high prevalence of chronic hepatitis B (CHB) infection; HCC is the fourth commonest cancer in men and the seventh commonest in women, and it is the third leading cause of cancer death in Hong Kong. The full spectrum of treatment modalities for HCC is available locally; however, there is currently no local consensus document detailing how these modalities should be used. Summary In a series of meetings held between May and October 2013, a multidisciplinary group of Hong Kong clinicians − liver surgeons, medical oncologists, clinical oncologists, hepatologists, and interventional radiologists − convened to formulate local recommendations on HCC management. These recommendations consolidate the most current evidence pertaining to HCC treatment modalities, together with the latest thinking of practicing clinicians engaged in HCC management, and give detailed guidance on how to deploy these modalities effectively for patients in various disease stages. Key messages Distinct from other regional guidelines, these recommendations provide guidance on the use of antiviral therapy to reduce the incidence of HCC in CHB patients with cirrhosis and to reduce recurrence of CHB-related HCC. PMID:26020029

  7. Breastfeeding intention among pregnant Hong Kong Chinese women.

    Science.gov (United States)

    Lau, Ying

    2010-09-01

    This study set out to (1) estimate the prevalence of three forms of feeding intention among 2,178 pregnant women in six of Hong Kong's regional hospitals and (2) identify the associated demographic, socioeconomic, obstetric and relational correlates. The research design was exploratory, cross-sectional, and quantitative. The Chinese version of a self-administered questionnaire was used to collect the demographic, socio-economic, and obstetric characteristics of the women. Couples' relationships were investigated using the Dyadic Adjustment Scale. All women in the second trimester of their pregnancies who attended the target antenatal clinics within the data collection period of December 2004 to December 2006 were recruited. The prevalence rates of breastfeeding, mixed feeding and artificial feeding were 53.9%, 14.8%, and 31.3%, respectively. Women who had been born in Hong Kong, lived in accommodation that was > or = 300 feet(2) (approximately 30 m(2)), had made an early antenatal booking, had a planned pregnancy, were experiencing their first pregnancy, and had a lower level of conflict with their partners were significantly more likely to opt for breastfeeding. Women who had been born in Hong Kong and already had children were significantly more likely to choose mixed feeding, compared with the artificial group in a multinomial logistic regression model. These findings suggest that effective promotion of breastfeeding during the prenatal period must target the correlates of feeding intention.

  8. The Mouse That Roared: The Democratic Movement in Hong Kong

    Directory of Open Access Journals (Sweden)

    Arif Dirlik

    2016-08-01

    Full Text Available The popular uprising in recent years in Hong Kong – “Occupy Central” a.k.a. Umbrella Movement – has again brought to the fore the question of the Special Administrative Region’s relationship with Mainland China post-1997 “handover” of the territory by the British colonial government to the People’s Republic of China. This article argues that the protests have their origins in a consciousness born of the anxieties provoked by the prospect of unification in the 1980s and 1990s, further evolved against the background of the unstable “one country, two systems” arrangement openly favoring the corporate and financial ruling class in Hong Kong which is in turn prepared to align its interests with those of the Communist regime in a mutually beneficial relationship. It also posits while the upheaval in Hong Kong bears similarities to other “Occupy” movements elsewhere in the economic issues that inform it, it may be viewed as the latest chapter in a narrative that goes back to the 1980s – the emergence of a neoliberal global capitalism of which the PRC has been an integral component, and the Tiananmen movement which was one of the earliest expressions of the social and political strains created by shifts in the global economy.

  9. Evolution of highly pathogenic avian H5N1 influenza viruses

    Energy Technology Data Exchange (ETDEWEB)

    Macken, Catherine A [Los Alamos National Laboratory; Green, Margaret A [Los Alamos National Laboratory

    2009-01-01

    Highly pathogenic avian H5N1 viruses have circulated in Southeast Asia for more than a decade, are now endemic in parts of this region, and have also spread to more than 60 countries on three continents. The evolution of these viruses is characterized by frequent reassortment events that have created a significant number of different genotypes, both transient and longer lasting. However, fundamental questions remain about the generation and perpetuation of this substantial genetic diversity. These gaps in understanding may, in part, be due to the difficulties of genotyping closely related viruses, and limitations in the size of the data sets used in analysis. Using our recently published novel genotyping procedure ('two-time test'), which is amenable to high throughput analysis and provides an increased level of resolution relative to previous analyses, we propose a detailed model for the evolution and diversification of avian H5N1 viruses. Our analysis suggests that (i) all current H5N1 genotypes are derived from a single, clearly defined sequence of initial reassortment events; (ii) reassortment of the polymerase and NP genes may have played an important role in avian H5N1 virus evolution; (iii) the current genotype Z viruses have diverged into three distinguishable sub-genotypes in the absence of reassortment; (iv) some potentially significant molecular changes appear to be correlated with particular genotypes (for example, reassortment of the internal genes is often paralleled by a change in the HA clade); and (v) as noted in earlier studies of avian influenza A virus evolution, novel segments are typically derived from different donors (i.e., there is no obvious pattern of gene linkage in reassortment). The model of avian H5N1 viral evolution by reassortment and mutation that emerges from our study provides a context within which significant amino acid changes may be revealed; it also may help in predicting the 'success' of newly emerging

  10. Interspecies transmission and host restriction of avian H5N1 influenza virus

    Institute of Scientific and Technical Information of China (English)

    LIU Di; LIU XiaoLing; YAN JingHua; LIU Wen-Jun; GAO George Fu

    2009-01-01

    Long-term endemicity of avian H5N1 influenza virus in poultry and continuous sporadic human infec-tions in several countries has raised the concern of another potential pandemic influenza. Suspicion of the avian origin of the previous pandemics results in the close investigation of the mechanism of in-terspecies transmission. Entry and fusion is the first step for the H5N1 influenza virus to get into the host cells affecting the host ranges. Therefore receptor usage study has been a major focus for the last few years. We now know the difference of the sialic acid structures and distributions in different spe-cies, even in the different parts of the same host. Many host factors interacting with the influenza virus component proteins have been identified and their role in the host range expansion and interspecies transmission is under detailed scrutiny. Here we review current progress in the receptor usage and host factors.

  11. Interspecies transmission and host restriction of avian H5N1 influenza virus

    Institute of Scientific and Technical Information of China (English)

    GAO; George; Fu

    2009-01-01

    Long-term endemicity of avian H5N1 influenza virus in poultry and continuous sporadic human infections in several countries has raised the concern of another potential pandemic influenza. Suspicion of the avian origin of the previous pandemics results in the close investigation of the mechanism of interspecies transmission. Entry and fusion is the first step for the H5N1 influenza virus to get into the host cells affecting the host ranges. Therefore receptor usage study has been a major focus for the last few years. We now know the difference of the sialic acid structures and distributions in different species, even in the different parts of the same host. Many host factors interacting with the influenza virus component proteins have been identified and their role in the host range expansion and interspecies transmission is under detailed scrutiny. Here we review current progress in the receptor usage and host factors.

  12. Avian Influenza (H5N1) Expert System using Dempster-Shafer Theory

    CERN Document Server

    Maseleno, Andino

    2012-01-01

    Based on Cumulative Number of Confirmed Human Cases of Avian Influenza (H5N1) Reported to World Health Organization (WHO) in the 2011 from 15 countries, Indonesia has the largest number death because Avian Influenza which 146 deaths. In this research, the researcher built an Avian Influenza (H5N1) Expert System for identifying avian influenza disease and displaying the result of identification process. In this paper, we describe five symptoms as major symptoms which include depression, combs, wattle, bluish face region, swollen face region, narrowness of eyes, and balance disorders. We use chicken as research object. Research location is in the Lampung Province, South Sumatera. The researcher reason to choose Lampung Province in South Sumatera on the basis that has a high poultry population. Dempster-Shafer theory to quantify the degree of belief as inference engine in expert system, our approach uses Dempster-Shafer theory to combine beliefs under conditions of uncertainty and ignorance, and allows quantitat...

  13. Avian influenza H5N1: an update on molecular pathogenesis

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    Avian influenza A virus constitutes a large threat to human health. Recent outbreaks of highly pathogenic avian influenza H5N1 virus in poultry and in humans have raised concerns that an influenza pandemic will occur in the near future. Transmission from avian species to humans remains sporadic, but the mortality associated with human infection is very high (about 62%). To date, there are no effective therapeutic drugs or a prophylactic vaccines available, which means that there is still a long way to go before we can eradicate or cure avian influenza. This review focuses on the molecular pathogenesis of avian influenza H5N1 virus infection. An understanding of the viral pathogenesis may facilitate the development of novel treatments or effective eradication of this fatal disease.

  14. Avian influenza H5N1: an update on molecular pathogenesis

    Institute of Scientific and Technical Information of China (English)

    WANG HongLiang; JIANG ChengYu

    2009-01-01

    Avian influenza A virus constitutes a large threat to human health. Recent outbreaks of highly patho-genic avian influenza H5N1 virus in poultry and in humans have raised concerns that an influenza pandemic will occur in the near future. Transmission from avian species to humans remains sporadic, but the mortality associated with human infection is very high (about 62%). To date, there are no effec-tive therapeutic drugs or a prophylactic vaccines available, which means that there is still a long way to go before we can eradicate or cure avian influenza. This review focuses on the molecular pathogenesis of avian influenza H5N1 virus infection. An understanding of the viral pathogenesis may facilitate the development of novel treatments or effective eradication of this fatal disease.

  15. Metapopulation dynamics enable persistence of influenza A, including A/H5N1, in poultry.

    Science.gov (United States)

    Hosseini, Parviez Rana; Fuller, Trevon; Harrigan, Ryan; Zhao, Delong; Arriola, Carmen Sofia; Gonzalez, Armandoe; Miller, Matthew Joshua; Xiao, Xiangming; Smith, Tom B; Jones, Jamie Holland; Daszak, Peter

    2013-01-01

    Highly pathogenic influenza A/H5N1 has persistently but sporadically caused human illness and death since 1997. Yet it is still unclear how this pathogen is able to persist globally. While wild birds seem to be a genetic reservoir for influenza A, they do not seem to be the main source of human illness. Here, we highlight the role that domestic poultry may play in maintaining A/H5N1 globally, using theoretical models of spatial population structure in poultry populations. We find that a metapopulation of moderately sized poultry flocks can sustain the pathogen in a finite poultry population for over two years. Our results suggest that it is possible that moderately intensive backyard farms could sustain the pathogen indefinitely in real systems. This fits a pattern that has been observed from many empirical systems. Rather than just employing standard culling procedures to control the disease, our model suggests ways that poultry production systems may be modified.

  16. Molecular epidemiology of influenza A (H5N1) viruses, Bangladesh, 2007-2011.

    Science.gov (United States)

    Hoque, Md Ahasanul; Tun, Hein Min; Hassan, Mohammad Mahmudul; Khan, Shahneaz Ali; Islam, Skm Azizul; Islam, Md Nurul; Giasuddin, Md; Osmani, Tabm Muzaffar Goni; Islam, Ariful; Thornton, Ronald Norman; Burgess, Graham William; Skerratt, Lee Francis; Selleck, Paul; Brun, Edgar; Debnath, Nitish Chandra; Leung, Frederick Chi-Ching

    2013-09-01

    To investigate the origins, evolution and patterns of spread of HPAI H5N1 outbreaks in Bangladesh, we performed a phylogenetic reconstruction analysis using Bayesian methods. The analysis was conducted using 81 hemagglutinin (HA) gene sequences from the H5N1 viruses isolated in Bangladesh from 2007 to 2011, together with 264 publicly available HA sequences of clade 2.2, 2.3.2 and 2.3.4 retrieved from GenBank. Our study provides evidence that clade 2.2.2 viruses that caused outbreaks in Bangladesh were lineages independent from the viruses introduced earlier into India. Furthermore, the Bangladesh clade 2.2.2 descendents subsequently spread to India and Bhutan. This has implications for avian influenza control in southern Asia suggesting multiple routes of entry of the virus including one pathway that spread to neighboring countries via Bangladesh.

  17. Respon Imun Itik Bali terhadap Berbagai Dosis Vaksin Avian Influenza H5N1

    Directory of Open Access Journals (Sweden)

    Ida Bagus Kade Suardana

    2009-09-01

    Full Text Available A study was carried out to investigate the immune response of Bali ducks against various doses ofAvian Influenza H5N1 vaccine. The study was carried out using a complete Random-Split in Time researchdesign as many as 40 of Bali ducks of 3 months age were kept separately in 4 groups. The ducks werevaccinated twice in two week interval with AI H5N1 vaccine of 0 (as negative control, 1/2, 1, and 2 doses.Sera were collected one day before first vaccination, then every week until three weeks after the secondvaccination. All sera were tested by hemaglutination inhibition (HI test. The result shows that antibodylevel with double dose was significantly higher than single dose, half dose, and negative control (P<0.01.However antibody level in ducks vaccinated with single and half dose did not show any significant difference(P > 0.05.

  18. Biosafety Considerations of Mammalian-Transmissible H5N1 Influenza

    OpenAIRE

    2012-01-01

    Abstract The ability to produce an H5N1 influenza virus that can be transmitted from human to human raises both biosecurity and biosafety concerns. After analyzing the biosafety risks of such a virus, we propose that it be handled at biosafety level 4 (BSL4) containment until and unless it becomes clear that the risks to humans and other mammals can be mitigated.

  19. Modelling H5N1 in Bangladesh across spatial scales: Model complexity and zoonotic transmission risk.

    Science.gov (United States)

    Hill, Edward M; House, Thomas; Dhingra, Madhur S; Kalpravidh, Wantanee; Morzaria, Subhash; Osmani, Muzaffar G; Yamage, Mat; Xiao, Xiangming; Gilbert, Marius; Tildesley, Michael J

    2017-09-01

    Highly pathogenic avian influenza H5N1 remains a persistent public health threat, capable of causing infection in humans with a high mortality rate while simultaneously negatively impacting the livestock industry. A central question is to determine regions that are likely sources of newly emerging influenza strains with pandemic causing potential. A suitable candidate is Bangladesh, being one of the most densely populated countries in the world and having an intensifying farming system. It is therefore vital to establish the key factors, specific to Bangladesh, that enable both continued transmission within poultry and spillover across the human-animal interface. We apply a modelling framework to H5N1 epidemics in the Dhaka region of Bangladesh, occurring from 2007 onwards, that resulted in large outbreaks in the poultry sector and a limited number of confirmed human cases. This model consisted of separate poultry transmission and zoonotic transmission components. Utilising poultry farm spatial and population information a set of competing nested models of varying complexity were fitted to the observed case data, with parameter inference carried out using Bayesian methodology and goodness-of-fit verified by stochastic simulations. For the poultry transmission component, successfully identifying a model of minimal complexity, which enabled the accurate prediction of the size and spatial distribution of cases in H5N1 outbreaks, was found to be dependent on the administration level being analysed. A consistent outcome of non-optimal reporting of infected premises materialised in each poultry epidemic of interest, though across the outbreaks analysed there were substantial differences in the estimated transmission parameters. The zoonotic transmission component found the main contributor to spillover transmission of H5N1 in Bangladesh was found to differ from one poultry epidemic to another. We conclude by discussing possible explanations for these discrepancies in

  20. Modelling H5N1 in Bangladesh across spatial scales: Model complexity and zoonotic transmission risk

    Directory of Open Access Journals (Sweden)

    Edward M. Hill

    2017-09-01

    Full Text Available Highly pathogenic avian influenza H5N1 remains a persistent public health threat, capable of causing infection in humans with a high mortality rate while simultaneously negatively impacting the livestock industry. A central question is to determine regions that are likely sources of newly emerging influenza strains with pandemic causing potential. A suitable candidate is Bangladesh, being one of the most densely populated countries in the world and having an intensifying farming system. It is therefore vital to establish the key factors, specific to Bangladesh, that enable both continued transmission within poultry and spillover across the human–animal interface. We apply a modelling framework to H5N1 epidemics in the Dhaka region of Bangladesh, occurring from 2007 onwards, that resulted in large outbreaks in the poultry sector and a limited number of confirmed human cases. This model consisted of separate poultry transmission and zoonotic transmission components. Utilising poultry farm spatial and population information a set of competing nested models of varying complexity were fitted to the observed case data, with parameter inference carried out using Bayesian methodology and goodness-of-fit verified by stochastic simulations. For the poultry transmission component, successfully identifying a model of minimal complexity, which enabled the accurate prediction of the size and spatial distribution of cases in H5N1 outbreaks, was found to be dependent on the administration level being analysed. A consistent outcome of non-optimal reporting of infected premises materialised in each poultry epidemic of interest, though across the outbreaks analysed there were substantial differences in the estimated transmission parameters. The zoonotic transmission component found the main contributor to spillover transmission of H5N1 in Bangladesh was found to differ from one poultry epidemic to another. We conclude by discussing possible explanations for

  1. Pathogenicity of human high pathogenic H5N1 virus with different plaque property

    Directory of Open Access Journals (Sweden)

    Yong-qiang LI

    2011-06-01

    Full Text Available Objective To determine the pathogenicity of human high pathogenic H5N1 virus with different plaque property,and provide a new train of thought and basis for research on crossing species-genus transmission of avian influenza virus.Methods Variants with different plaque property(larger-and smaller-plaque variant were isolated from A/Beijing/01/03(H5N1(BJ01 by the plaque purification.Mice were inoculated intranasally(i.n. with each kind of isolated variant and monitored for 14 days to record and calculate the body weight change and the survival rate.The difference in pathogenicity of isolated variants was estimated with proper principle of statistics.Results The plaques of original strain of BJ01 virus were heterogeneous with various size and shape.Larger-plaque variants(L1 and L2 and smaller-plaque variants(S1,S2 and S3 were isolated separately.The pathogenicity was higher in S1 and S2 variants than in S3,L1 and L2 variants,and that of L2 variant was the lowest.Variants forming different plaques were heterogeneous in pathogenicity,and those forming same plaques were also heterogeneous in pathogenicity.Conclusion There is no linear correlation between the pathogenicity of variants and the size of plaque they formed.The variants with different pathogenicity could be isolated from the same H5N1 virus strain by plaque purification.These results would provide a basis for vaccine development and the studies on molecular mechanism of H5N1 virus.

  2. Avian influenza virus (H5N1; effects of physico-chemical factors on its survival

    Directory of Open Access Journals (Sweden)

    Hameed Sajid

    2009-03-01

    Full Text Available Abstract Present study was performed to determine the effects of physical and chemical agents on infective potential of highly pathogenic avian influenza (HPAI H5N1 (local strain virus recently isolated in Pakistan during 2006 outbreak. H5N1 virus having titer 108.3 ELD50/ml was mixed with sterilized peptone water to get final dilution of 4HA units and then exposed to physical (temperature, pH and ultraviolet light and chemical (formalin, phenol crystals, iodine crystals, CID 20, virkon®-S, zeptin 10%, KEPCIDE 300, KEPCIDE 400, lifebuoy, surf excel and caustic soda agents. Harvested amnio-allantoic fluid (AAF from embryonated chicken eggs inoculated with H5N1 treated virus (0.2 ml/egg was subjected to haemagglutination (HA and haemagglutination inhibition (HI tests. H5N1 virus lost infectivity after 30 min at 56°C, after 1 day at 28°C but remained viable for more than 100 days at 4°C. Acidic pH (1, 3 and basic pH (11, 13 were virucidal after 6 h contact time; however virus retained infectivity at pH 5 (18 h, 7 and 9 (more than 24 h. UV light was proved ineffectual in inactivating virus completely even after 60 min. Soap (lifebuoy®, detergent (surf excel® and alkali (caustic soda destroyed infectivity after 5 min at 0.1, 0.2 and 0.3% dilution. All commercially available disinfectants inactivated virus at recommended concentrations. Results of present study would be helpful in implementing bio-security measures at farms/hatcheries levels in the wake of avian influenza virus (AIV outbreak.

  3. The Attitudes of Hong Kong Primary School Principals toward Integrated Education

    Science.gov (United States)

    Sharma, Umesh; Chow, Emily W. S.

    2008-01-01

    Positive attitudes of key stakeholders, such as school principals, towards a new policy are considered a necessary pre-requisite to implement any such policy. Hong Kong has recently formulated a policy that supports the integration of students with disabilities into regular schools. This study investigated the attitudes of Hong Kong primary school…

  4. School Adjustment, Social Support, and Mental Health of Mainland Chinese College Students in Hong Kong

    Science.gov (United States)

    Chui, Raymond Chi-Fai; Chan, Chi-Keung

    2017-01-01

    We investigated the relationship of school adjustment and social support with the mental health of mainland Chinese college students studying in Hong Kong. During the spring semester in 2011, 384 mainland Chinese college students across the postsecondary institutions in Hong Kong completed a questionnaire. Results showed that better school…

  5. Indicators and Implications of Zero Tolerance of Corruption: The Case of Hong Kong

    Science.gov (United States)

    Gong, Ting; Wang, Shiru

    2013-01-01

    Notwithstanding the voluminous studies of Hong Kong's anticorruption experience and the admiration the ICAC has earned from other governments as a model for "institutional engineering," little is known about how the public in Hong Kong has perceived and responded to corruption. Less clear is what factors beyond a powerful and independent…

  6. Prevalence of Insomnia and Its Psychosocial Correlates among College Students in Hong Kong

    Science.gov (United States)

    Sing, C. Y.; Wong, W. S.

    2010-01-01

    Objective: This study examined the prevalence of insomnia and its psychosocial correlates among college students in Hong Kong. Participants: A total of 529 Hong Kong college students participated in the study. Methods: Participants completed a self-reported questionnaire that included the Pittsburgh Sleep Quality Index (PSQI), the Revised Life…

  7. The Quality of Hong Kong's Self-Financing Sub-Degree Education from an Economic Perspective

    Science.gov (United States)

    Chan, Chi Wai

    2012-01-01

    This paper examines the quality of Hong Kong's sub-degree level education provided by the self-financing institutes in terms of its impact on the earnings of workers, based on Hong Kong's 2006 by-census data. Education is an investment in human capital that enhances the productivity of workers and increases their lifetime incomes; and a more…

  8. Stumbling Blocks in the Implementation of Accounting Education Reform: Evidence from Hong Kong

    Science.gov (United States)

    Chen, Theodore T. Y.

    2016-01-01

    In determining whether stumbling blocks exist in the implementation of accounting education reform in Hong Kong, a survey questionnaire was sent to all accounting departments at public universities representing accounting academics, and the Hong Kong Institute of Certified Public Accountants representing the profession. The survey showed that both…

  9. The Challenges for Educational Achievements of Young Mainland Chinese Migrants in Hong Kong

    Science.gov (United States)

    Wong, Yu-Cheung

    2011-01-01

    Hong Kong's population has increased by around one million per decade from the end of World War II till the 1990s. A large proportion of this growth came from the mass influx of migrants from Mainland China, and the children born to them. During the 1960s and 1970s when Hong Kong's economy was booming rapidly, career advancement opportunities were…

  10. Dancing with Global Trends: Higher Education Policy and University Governance in Hong Kong, 1997-2012

    Science.gov (United States)

    Lo, William Yat Wai; Tang, Hei-Hang Hayes

    2017-01-01

    This article examines the significance of global trends in higher education (HE) development in Hong Kong between 1997 and 2012. Two trends, massification and internationalisation, are considered key driving forces that shaped Hong Kong's HE policy during the period. The former refers to government measures to widen participation in HE. The latter…

  11. Indicators and Implications of Zero Tolerance of Corruption: The Case of Hong Kong

    Science.gov (United States)

    Gong, Ting; Wang, Shiru

    2013-01-01

    Notwithstanding the voluminous studies of Hong Kong's anticorruption experience and the admiration the ICAC has earned from other governments as a model for "institutional engineering," little is known about how the public in Hong Kong has perceived and responded to corruption. Less clear is what factors beyond a powerful and independent…

  12. Social Development in Hong Kong: Development Issues Identified by Social Development Index (SDI)

    Science.gov (United States)

    Chua, Hoi-wai; Wong, Anthony K. W.; Shek, Daniel T. L.

    2010-01-01

    Surviving the aftermaths of the Asian Financial Crisis and SARS in 2003, Hong Kong's economy has re-gained its momentum and its economic growth has been quite remarkable too in recent few years. Nevertheless, as reflected by the Social Development Index (SDI), economic growth in Hong Kong does not seem to have benefited the people of the city at…

  13. Hong Kong Chinese Community Leaders' Perspectives on Family Health, Happiness and Harmony: A Qualitative Study

    Science.gov (United States)

    Chan, Sophia S. C.; Viswanath, K.; Au, Doreen W. H.; Ma, C. M. S.; Lam, W. W. T.; Fielding, R.; Leung, G. M.; Lam, Tai-Hing

    2011-01-01

    This paper examines the views of Hong Kong community leaders on the underlying issues that affect family health, happiness and harmony (3Hs) in Hong Kong. Using a community reconnaissance method, a series of individual in-depth interviews with 26 leaders that represent neighbourhoods of diverse socio-economic status (SES) from June to August 2008…

  14. The Contributions of Kenelm Hutchinson Digby to Orthopaedics in Hong Kong Part 2

    Directory of Open Access Journals (Sweden)

    Kuo-tai Louis Fu

    2016-06-01

    Full Text Available As the first professor of surgery in Hong Kong, Kenelm Hutchinson Digby had the tremendous task of building a new clinical department in the infant University of Hong Kong from scratch. Despite his heavy commitments in clinical, administrative, and teaching responsibilities, he pioneered novel orthopaedic treatment principles and techniques, in addition to that of general surgery.

  15. Exploring the Reading-Writing Connection in Chinese Children with Dyslexia in Hong Kong

    Science.gov (United States)

    Chan, David W.; Ho, Connie S.-H.; Tsang, Suk-Man; Lee, Suk-Han; Chung, Kevin K. H.

    2006-01-01

    Comparing the analyses based on the data of 1,235 Chinese children referred for government services and subsequently diagnosed as children with dyslexia in Hong Kong and those of 690 Chinese children in the sample for the normative study of the Hong Kong Test of Specific Learning Difficulties in Reading and Writing, we explored the reading-writing…

  16. Portrayals of Pro-Beijing Workers' Night Schools in Hong Kong from 1946 to Post-1997

    Science.gov (United States)

    Lau, Chui Shan

    2011-01-01

    This study focuses on the transformation of pro-Beijing labour education in the socio-political context of Hong Kong. It explores the reasons that Hong Kong pro-Beijing educators initiated Workers' Night Schools for adults; the organisation of schools in many locales and the transformation of labour education that workers received in these…

  17. Colonialism's Aftermath in Asia: A Snapshot View of Bilingualism in Hong Kong.

    Science.gov (United States)

    Pennington, M. C.

    1998-01-01

    Looks at the shifting profile of bilingualism in Hong Kong. Whereas Hong Kong society could once be characterized as diglossic, with differentiation of English and Cantonese in terms of their functions and status as "high" and "low" languages, it is currently undergoing a rapid shift away from diglossia, with erosion of these…

  18. The (Un)Changing Role of Mandarin Chinese in Language Education in Hong Kong.

    Science.gov (United States)

    Leung, Cheung-Shing Samuel; Yuen-Fan, Lomita Wong

    1996-01-01

    Explains how the education system in Hong Kong has helped to shape Hong Kong's past diglossia and how the country is preparing to face the changes inherent in the new political context in which Putonghua will be another element. Reports on the status and use of Cantonese and Putonghua (the national language of the People's Republic of China). (33…

  19. The Financial Centres of Shanghai and Hong Kong: Competition or Complementarity?

    NARCIS (Netherlands)

    B. Karreman (Bas); G.A. van der Knaap (Bert)

    2007-01-01

    textabstractThe contemporary rise of China in the new geo-economy is increasingly pressurising the spatial distribution of financial activity in mainland China and Hong Kong. With the re-emergence of Shanghai, many people foresee the furture demise of Hong Kong as the most important financial centre

  20. The Financial Centres of Shanghai and Hong Kong: Competition or Complementarity?

    NARCIS (Netherlands)

    B. Karreman (Bas); G.A. van der Knaap (Bert)

    2007-01-01

    textabstractThe contemporary rise of China in the new geo-economy is increasingly pressurising the spatial distribution of financial activity in mainland China and Hong Kong. With the re-emergence of Shanghai, many people foresee the furture demise of Hong Kong as the most important financial centre

  1. The Mainland,Hong Kong and Macao Intellectual Property Symposium 2003

    Institute of Scientific and Technical Information of China (English)

    Our; Correspondent

    2004-01-01

    The Mainland,Hong Kong SAR and Macao SARIntellectual Property Symposium 2003,jointlysponsored by the State Intellectual Property Office ofChina,the Hong Kong SAR Intellectual PropertyDepartment,Macao SAR Economic Services,washeld at the China Intellectual Property Training Centrein Beijing from 11-12 December 2003.Over 140

  2. Voices of Donors: Case Reports of Body Donation in Hong Kong

    Science.gov (United States)

    Chiu, Hei Yeung; Ng, Kwok Sing; Ma, Sin Kwan; Chan, Chi Hung; Ng, Sheung Wah; Tipoe, George L.; Chan, Lap Ki

    2012-01-01

    Body donation is important for medical education and academic research. However, it is relatively rare in Hong Kong when compared with many Western countries. Comprehensive research has been performed on the motivation for body donation in Western countries; however, there is still insufficient research on body donation in Hong Kong to provide…

  3. Making Sense of Divergent Perceptions of Racial-Ethnic Discrimination in Hong Kong

    Science.gov (United States)

    Chan, Carol Wing Sze; Lam, Beatrice Oi-yeung; Teng, Yue; Lee, Moosung

    2015-01-01

    Behind a veneer of cosmopolitanism in Hong Kong, racial-ethnic discrimination is pervasively experienced by ethnic minorities such as South and South East Asians (hereafter referred to as South/South East Asians). It is the aim of this study to examine why Hong Kong Chinese and South/South East Asians express what seem to be divergent perceptions…

  4. Earth Sciences as a Vehicle for Gifted Education--The Hong Kong Experience

    Science.gov (United States)

    Murphy, Phillip J.; Chan, Lung Sang; Murphy, Elizabeth

    2012-01-01

    The development and delivery of an Earth-science-focused short course designed to prepare Hong Kong students for university level study is described. Earth sciences provide an inspirational and challenging context for learning and teaching in Hong Kong's increasingly skills-based curriculum. (Contains 3 figures and 4 online resources.)

  5. Global Agenda, Local Responses: Changing Education Governance in Hong Kong's Higher Education

    Science.gov (United States)

    Chan, David K. K.

    2007-01-01

    Hong Kong has undergone a series of educational reforms since the mid 1990s in response to the tidal wave of globalisation. This article tries to examine the recent education reforms in Hong Kong's higher education within the global context, by putting into perspective a discussion of its policy implications of marketisation, privatisation and…

  6. Developing a Rasch Measurement Physical Fitness Scale for Hong Kong Primary School-Aged Students

    Science.gov (United States)

    Yan, Zi; Bond, Trevor G.

    2011-01-01

    The main purpose of this study was to develop a Rasch Measurement Physical Fitness Scale (RMPFS) based on physical fitness indicators routinely used in Hong Kong primary schools. A total of 9,439 records of students' performances on physical fitness indicators, retrieved from the database of a Hong Kong primary school, were used to develop the…

  7. Ideology, Linguistic Capital and the Medium of Instruction in Hong Kong.

    Science.gov (United States)

    Morrison, Keith; Lui, Icy

    2000-01-01

    Examines the links between linguistic capital, cultural capital, linguistic imperialism, and the use of English as the medium of instruction (MOI) in Hong Kong. Suggests that the notion of linguistic imperialism in Hong Kong is superceded by the notion of linguistic capital, although neither presents a complete analysis of the MOI issue in Hong…

  8. A Model of Active Ageing through Elder Learning: The Elder Academy Network in Hong Kong

    Science.gov (United States)

    Tam, Maureen

    2013-01-01

    This article presents the Elder Academy (EA) Network as the policy and practice in promoting active ageing through elder learning in Hong Kong. First, the article examines how the change in demographics and the prevalent trend of an ageing population have propelled the government in Hong Kong to tackle issues and challenges brought about by an…

  9. Similarities and Differences in Views of Ageing and Learning in Hong Kong and Australia

    Science.gov (United States)

    Tam, Maureen; Boulton-Lewis, Gillian; Buys, Laurie; Chui, Ernest

    2017-01-01

    This article is an overview and summary of the findings from a General Research Fund project funded (2012-2014) by the Research Grants Council of the University Grants Committee of Hong Kong to investigate cross cultural understanding of ageing and learning by seniors in Hong Kong and Australia. Results have been published separately in…

  10. Earth Sciences as a Vehicle for Gifted Education--The Hong Kong Experience

    Science.gov (United States)

    Murphy, Phillip J.; Chan, Lung Sang; Murphy, Elizabeth

    2012-01-01

    The development and delivery of an Earth-science-focused short course designed to prepare Hong Kong students for university level study is described. Earth sciences provide an inspirational and challenging context for learning and teaching in Hong Kong's increasingly skills-based curriculum. (Contains 3 figures and 4 online resources.)

  11. A Pilot Study of Using Jazz Warm Up Exercises in Primary School Choir in Hong Kong

    Science.gov (United States)

    Chen, Jason Chi Wai; Lee, Han Wai

    2013-01-01

    This pilot study is to examine whether it is valuable to implement jazz choral practice in Hong Kong primary school setting. The findings can serve as a reference to explore the possibilities of promoting jazz education in Asian countries or in China. The participants were 70 public primary school students from grade 2 to 5 in Hong Kong. All…

  12. The financial centres of Shanghai and Hong Kong: Compentition or complementarity?

    NARCIS (Netherlands)

    B. Karreman (Bas); G.A. van der Knaap (Bert)

    2009-01-01

    textabstractThe contemporary rise of China in the new geo-economy is increasingly pressurising the spatial distribution of financial activity in mainland China and Hong Kong. With the reemergence of Shanghai, many people foresee the future demise of Hong Kong as the most important financial centre f

  13. Hong Kong Chinese Community Leaders' Perspectives on Family Health, Happiness and Harmony: A Qualitative Study

    Science.gov (United States)

    Chan, Sophia S. C.; Viswanath, K.; Au, Doreen W. H.; Ma, C. M. S.; Lam, W. W. T.; Fielding, R.; Leung, G. M.; Lam, Tai-Hing

    2011-01-01

    This paper examines the views of Hong Kong community leaders on the underlying issues that affect family health, happiness and harmony (3Hs) in Hong Kong. Using a community reconnaissance method, a series of individual in-depth interviews with 26 leaders that represent neighbourhoods of diverse socio-economic status (SES) from June to August 2008…

  14. A Study of the Implementation of Sex Education in Hong Kong Secondary Schools

    Science.gov (United States)

    Che, Fok Shui

    2005-01-01

    Sex education is not treated as an important subject in the school curriculum of Hong Kong. The Hong Kong Education Department issued in 1986 and 1997, respectively, two guidelines on sex education for schools' reference. The 1997 Guidelines cover a broader conceptual framework relating to different aspects of human sexuality and also include…

  15. Examining Factors Affecting Science Achievement of Hong Kong in PISA 2006 Using Hierarchical Linear Modeling

    Science.gov (United States)

    Lam, Terence Yuk Ping; Lau, Kwok Chi

    2014-01-01

    This study uses hierarchical linear modeling to examine the influence of a range of factors on the science performances of Hong Kong students in PISA 2006. Hong Kong has been consistently ranked highly in international science assessments, such as Programme for International Student Assessment and Trends in International Mathematics and Science…

  16. The Struggle between Globalisation, Nationalism and Music Education in Hong Kong

    Science.gov (United States)

    Ho, Wai-Chung; Law, Wing-Wah

    2009-01-01

    The year 2008 marked the 11th anniversary of Hong Kong's return from the UK to the People's Republic of China. In this decade, the Hong Kong Special Administrative Region Government has repeatedly emphasised the importance of the development of national identity and patriotism in school education, and has at the same time introduced diverse…

  17. Values Education in Hong Kong School Music Education: A Sociological Critique

    Science.gov (United States)

    Law, Wing-Wah; Ho, Wai-Chung

    2004-01-01

    This article examines the social development of Hong Kong's cultural and national identity since its return from the UK to the People's Republic of China (PRC) nearly six years ago, focusing on the extent to which Hong Kong students are now inculcated in traditional Chinese music and express their devotion to the PRC through singing the national…

  18. Social Developments and School Music Education: The Struggles in Hong Kong

    Science.gov (United States)

    Ho, Wai-Chung

    2009-01-01

    This paper explores two current issues in the educational policies and practices of Hong Kong that have been shaped by the emergence of the nation-state and the return of Hong Kong's sovereignty from the UK to the People's Republic of China on 1 July 1997. Since this time there have been two great challenges facing music education. The first…

  19. The Impact of the Medium of Instruction in Hong Kong Secondary Schools on Tertiary Students' Vocabulary

    Science.gov (United States)

    Lin, Linda H. F.; Morrison, Bruce

    2010-01-01

    Following the hand-over of Hong Kong to China in 1997, the medium of instruction in most secondary schools in Hong Kong was changed from English to Chinese. Concerns have been expressed that the English language proficiency level of pupils whose secondary school medium of instruction (MOI) is Chinese is lower than that of those whose MOI is…

  20. A Pilot Study of Using Jazz Warm Up Exercises in Primary School Choir in Hong Kong

    Science.gov (United States)

    Chen, Jason Chi Wai; Lee, Han Wai

    2013-01-01

    This pilot study is to examine whether it is valuable to implement jazz choral practice in Hong Kong primary school setting. The findings can serve as a reference to explore the possibilities of promoting jazz education in Asian countries or in China. The participants were 70 public primary school students from grade 2 to 5 in Hong Kong. All…

  1. Cognitive and Affective Costs of Bilingual Education: A Look at the Hong Kong Experience.

    Science.gov (United States)

    Ripple, R. E.; And Others

    A study of the impact of language of instruction in schools on the divergent thinking, self-esteem, and locus of control of expatriate and Hong Kong native Chinese adolescents is reported and some of the cognitive and affective costs of the immersion method of bilingual education are examined. Hong Kong children in most schools must change…

  2. Hong Kong Parents' Perceptions of Benefits of Music to Their Children

    Science.gov (United States)

    Choi, Angel Lai Yan; Tse, Jennie Chen Yee; So, Cindy Sin Ni; Yeung, Alexander Seeshing

    2005-01-01

    Background: In Hong Kong, many parents encourage their children to take extra music lessons beyond normal school hours. This study investigates parents' perceptions of the benefits of music to children. Aims: To investigate why many parents in Hong Kong encourage their children to take extra music lessons beyond normal school hours, and to examine…

  3. Analysing Complex Policy Change in Hong Kong: What Role for Critical Discourse Analysis?

    Science.gov (United States)

    Cheng, Annie Y. N.

    2009-01-01

    Purpose: The Hong Kong government recently reformed pre-primary education with the introduction of a voucher scheme. At the time this policy caused considerable opposition from across Hong Kong Society. This paper seeks to use Fairclough's model of critical discourse analysis to explore a key policy text and seeks to assess to what extent such an…

  4. The Development of Local Private Primary and Secondary Schooling in Hong Kong, 1841-2012

    Science.gov (United States)

    Cheung, Alan C. K.; Randall, E. Vance; Tam, Man Kwan

    2016-01-01

    Purpose: This paper is a historical review of the development of private primary and secondary education in Hong Kong from 1841-2012. The purpose of this paper is to examine the evolving relationship between the state and private schools in Hong Kong. Design/methodology/approach: This paper utilizes sources from published official documents,…

  5. Dancing with Global Trends: Higher Education Policy and University Governance in Hong Kong, 1997-2012

    Science.gov (United States)

    Lo, William Yat Wai; Tang, Hei-Hang Hayes

    2017-01-01

    This article examines the significance of global trends in higher education (HE) development in Hong Kong between 1997 and 2012. Two trends, massification and internationalisation, are considered key driving forces that shaped Hong Kong's HE policy during the period. The former refers to government measures to widen participation in HE. The latter…

  6. Developing a Rasch Measurement Physical Fitness Scale for Hong Kong Primary School-Aged Students

    Science.gov (United States)

    Yan, Zi; Bond, Trevor G.

    2011-01-01

    The main purpose of this study was to develop a Rasch Measurement Physical Fitness Scale (RMPFS) based on physical fitness indicators routinely used in Hong Kong primary schools. A total of 9,439 records of students' performances on physical fitness indicators, retrieved from the database of a Hong Kong primary school, were used to develop the…

  7. Portrayals of Pro-Beijing Workers' Night Schools in Hong Kong from 1946 to Post-1997

    Science.gov (United States)

    Lau, Chui Shan

    2011-01-01

    This study focuses on the transformation of pro-Beijing labour education in the socio-political context of Hong Kong. It explores the reasons that Hong Kong pro-Beijing educators initiated Workers' Night Schools for adults; the organisation of schools in many locales and the transformation of labour education that workers received in these…

  8. The Perfect Marriage?--Language and Art Criticism in the Hong Kong Public Examination Context

    Science.gov (United States)

    Lau, Chung-yim; Tam, Cheung-on

    2017-01-01

    Art education in Hong Kong has undergone various changes in response to educational reform. In art assessment, a major change in the Hong Kong New Senior Secondary (NSS) Curriculum is the inclusion of art criticism as a compulsory component of the new public examination. Assessing students' abilities to interpret art in an art criticism public…

  9. Stumbling Blocks in the Implementation of Accounting Education Reform: Evidence from Hong Kong

    Science.gov (United States)

    Chen, Theodore T. Y.

    2016-01-01

    In determining whether stumbling blocks exist in the implementation of accounting education reform in Hong Kong, a survey questionnaire was sent to all accounting departments at public universities representing accounting academics, and the Hong Kong Institute of Certified Public Accountants representing the profession. The survey showed that both…

  10. Class Size and Language Learning in Hong Kong: The Students' Perspective

    Science.gov (United States)

    Harfitt, Gary James

    2012-01-01

    Background: There is currently ongoing debate in Hong Kong between the teachers' union and the Government on the reduction of large class size (typically more than 40 students) in secondary schools and whether smaller class sizes might facilitate improvements in teaching and learning. In fact, many Hong Kong secondary schools have already started…

  11. Identity and Sense of Belonging in Post-Colonial Education in Hong Kong

    Science.gov (United States)

    Kuah-Pearce, Khun Eng; Fong, Yiu-Chak

    2010-01-01

    This paper explores the construction of local and national identities among secondary school students in post-colonial Hong Kong. As a Chinese society that has undergone a prolonged period of British colonial rule, the reunification of capitalist Hong Kong with the motherland under socialism in 1997 has set the context for a negotiation of…

  12. Emotional Autonomy and Perceived Parenting Styles: Relational Analysis in the Hong Kong Cultural Context

    Science.gov (United States)

    Chan, Kwok Wai; Chan, Siu Mui

    2009-01-01

    Three hundred and seven teacher education students of a Hong Kong university were administered two questionnaires, one measuring emotional autonomy (EAS) and the other measuring perceived parenting styles (PAQ) of their parents. It was found that the Hong Kong teacher education students tended to be autonomous and they characterized their parents…

  13. Predictors of Suicide Ideation and Depression in Hong Kong Adolescents: Perceptions of Academic and Family Climates

    Science.gov (United States)

    Lee, Margaret T. Y.; Wong, Betty P.; Chow, Bonnie W.-Y.; McBride-Chang, Catherine

    2006-01-01

    The unique dimensions of perceptions of school and family contributing to depression and suicide ideation in Hong Kong adolescents were examined in two studies. In Study 1, among 327 Hong Kong Chinese female students ages 13-18, 47% reported some suicide ideation. Suicide ideation was significantly associated with depression, test anxiety,…

  14. Liberal Studies Reform in Hong Kong Secondary Education: Contrasting Desirability with Feasibility

    Science.gov (United States)

    Fok, Ping Kwan

    2016-01-01

    In major curriculum reforms, there are inevitably gaps between design and implementation issues, taking the introduction of liberal studies (LS) into the senior secondary curriculum in Hong Kong as a classic example. The current paper illustrates how the implementation of LS as a compulsory core subject has impacted noticeably on Hong Kong senior…

  15. The Partisan Press in Hong Kong: Between British Colonial Rule and Chinese Politics.

    Science.gov (United States)

    Lee, Chin-Chuan

    The aim of this paper is to provide a socio-historical perspective on the continuity and change of the Chinese press in Hong Kong. Divided into four sections, the paper examines (1) the partisan press structure as a microcosm of China's interparty struggle; (2) the rise of the market-oriented centrist press since 1970 as a result of Hong Kong's…

  16. Shifting Journalistic Paradigms: Editorial Stance and Political Transition in Hong Kong.

    Science.gov (United States)

    Chan, Joseph Man; Lee, Chin-Chuan

    This paper suggests that the upcoming transfer of Hong Kong from Great Britain to the People's Republic of China (PRC) in 1997, offers a unique opportunity to observe how changing configurations in the political environment influence mass media. The article investigates how the Hong Kong press, which spans the entire left-center-right ideological…

  17. Prevention and control of highly pathogenic avian influenza with particular reference to H5N1.

    Science.gov (United States)

    Capua, Ilaria; Cattoli, Giovanni

    2013-12-05

    Highly pathogenic avian influenza viruses of the H5N1 subtype emerged in Far East Asia in 1996 and spread in three continents in a period of 10 or less years. Before this event, avian influenza infections caused by highly pathogenic viruses had occurred in many different countries, causing minor or major outbreaks, and had always been eradicated. The unique features of these H5N1 viruses combined to the geographic characteristics of the area of emergence, including animal husbandry practices, has caused this subtype to become endemic in several Asian countries, as well as in Egypt. Our aim is to review the direct and indirect control strategies with the rationale for use, advantages and shortcomings - particularly resulting from practicalities linked to field application and economic constraints. Certainly, in low income countries which have applied vaccination, this has resulted in a failure to eradicate the infection. Although the number of infected countries has dropped from over 40 (2006) to under 10 (2012), the extensive circulation of H5N1 in areas with high poultry density still represents a risk for public and animal health.

  18. Characterization of H5N1 influenza viruses isolated from humans in vitro

    Directory of Open Access Journals (Sweden)

    Kameoka Masanori

    2010-06-01

    Full Text Available Abstract Since December 1997, highly pathogenic avian influenza A H5N1viruses have swept through poultry populations across Asian countries and been transmitted into African and European countries. We characterized 6 avian influenza H5N1 viruses isolated from humans in 2004 in Thailand. A highly pathogenic (HP KAN353 strain showed faster replication and higher virulence in embryonated eggs compared to other strains, especially compared to the low pathogenic (LP SP83 strain. HP KAN353 also showed strong cytopathogenicity compared to SP83 in Madin-Darby canine kidney cells. Interestingly, LP SP83 induced smaller plaques compared to other strains, especially HP KAN353. PB2 amino acid 627E may contribute to low virulence, whereas either PB2 amino acid 627 K or the combination of 627E/701N seems to be associated with high virulence. The in vitro assays used in this study may provide the basis for assessing the pathogenesis of influenza H5N1 viruses in vivo.

  19. Serosurveillance study on transmission of H5N1 virus during a 2006 avian influenza epidemic.

    Science.gov (United States)

    Ceyhan, M; Yildirim, I; Ferraris, O; Bouscambert-Duchamp, M; Frobert, E; Uyar, N; Tezer, H; Oner, A F; Buzgan, T; Torunoglu, M A; Ozkan, B; Yilmaz, R; Kurtoglu, M G; Laleli, Y; Badur, S; Lina, B

    2010-09-01

    In 2006 an outbreak of avian influenza A(H5N1) in Turkey caused 12 human infections, including four deaths. We conducted a serological survey to determine the extent of subclinical infection caused by the outbreak. Single serum samples were collected from five individuals with avian influenza whose nasopharyngeal swabs tested positive for H5 RNA by polymerase chain reaction, 28 family contacts of the cases, 95 poultry cullers, 75 individuals known to have had contact with diseased chickens and 81 individuals living in the region with no known contact with infected chickens and/or patients. Paired serum samples were collected from 97 healthcare workers. All sera were tested for the presence of neutralizing antibodies by enzyme-linked immunoassay, haemagglutination inhibition and microneutralization assays. Only one serum sample, from a parent of an avian influenza patient, tested positive for H5N1 by microneutralization assay. This survey shows that there was minimal subclinical H5N1 infection among contacts of human cases and infected poultry in Turkey in 2006. Further, the low rate of subclinical infection following contact with diseased poultry gave further support to the reported low infectivity of the virus.

  20. Influenza A aviária (H5N1: a gripe do frango Avian influenza A (H5N1: the bird flu

    Directory of Open Access Journals (Sweden)

    Cássio da Cunha Ibiapina

    2005-10-01

    Full Text Available Este estudo tem como objetivo rever a literatura sobre o vírus influenza A aviária (H5N1. O levantamento bibliográfico foi realizado nos bancos de dados eletrônicos Medline, MD Consult, HighWire, Medscape e Literatura Latinoamericana y del Caribe en Ciencias de la Salud (LILACS, Literatura Latinoamericana e do Caribe em Ciências da Saúde, e por pesquisa direta, referentes aos últimos dez anos. Foram selecionados 32 artigos originais abordando os surtos recentes de infecção por um subtipo de vírus influenza A aviária, o H5N1, em criações de aves domésticas na Ásia, que resultaram em importantes prejuízos econômicos e repercussões em saúde pública, além de casos de infecção humana de alta letalidade. A maioria dos casos está associada com a exposição direta a aves infectadas ou superfícies contaminadas com excrementos dessas aves, porém foi confirmada a transmissão entre humanos. O período de incubação foi de dois a quatro dias. As manifestações clínicas variaram de infecção assintomática e doença leve do trato respiratório superior a pneumonia grave e falência múltipla de órgãos. A radiografia de tórax pode apresentar infiltrado intersticial bilateral, colapso lobar, consolidação focal e broncograma aéreo sem derrame pleural. A presença de linfopenia indica pior prognóstico. O tratamento de suporte parece ser o único tratamento aceitável. Os fatores de risco para mau prognóstico incluem idade avançada, demora na hospitalização, envolvimento do trato respiratório inferior, baixa contagem de leucócitos totais e linfopenia à admissão. Controlar os surtos em aves domésticas e o contato entre seres humanos e tais aves deve ser a prioridade no manejo da doença em nível de saúde pública, e medidas e conhecimentos acerca da doença devem ser amplamente divulgados.The objective of this study was to review the literature related to avian influenza A (H5N1. The bibliographic research was

  1. Bureaucratic justice: the incarceration of mainland Chinese women working in Hong Kong's sex industry.

    Science.gov (United States)

    Laidler, Karen Joe; Petersen, Carole; Emerton, Robyn

    2007-02-01

    Since Hong Kong's return to the People's Republic of China (PRC) there has been a significant rise in the number of Chinese visitors to Hong Kong, including women crossing the border to engage in sex work. Sex work itself is not a crime in Hong Kong, but related activities, like soliciting, are prohibited. Sex work is treated as work for immigration purposes, and visitors who engage in work without an employment visa are breaching their conditions of stay. More than 10,000 mainland Chinese women have been arrested, prosecuted, and sentenced in recent years, causing the correctional population to expand beyond capacity. The authors examine the experiences of 58 incarcerated women in their encounters with the Hong Kong criminal justice system and find that women are processed in a highly routinized bureaucratic manner. They consider the purpose served by the largely bureaucratic form of justice that has emerged in response to migrant sex workers in Hong Kong.

  2. The stroller in the virtual city: Spatial practice of Hong Kong players in Sleeping Dogs

    Directory of Open Access Journals (Sweden)

    Ge Zhang

    2014-03-01

    Full Text Available Sleeping Dogs is an open-world role-playing game developed by United Front Games, a Canadian Studio based in Vancouver, in conjunction with Square Enix London Studios and released by Square Enix in 2012. The game features the city of Hong Kong and the society of Chinese Triads. While the game itself is mainly a representation of post-colonial Hong Kong targeting a transnational audience entrenched in similar gameplay mechanics of the genre, the native Hong Kong players react to these reconstructions of Hong Kong through their own gameplay and unique interpretations. The virtual city is not a static representation but a congruence of vigorous interactions between the originally designed space and gamic actions of the players. This paper seeks to explore the spatial and bodily practices of Sleeping Dogs players in the virtual terrain of Hong Kong through the lens of Lefebvre’s spatial theory.

  3. Humor styles and loneliness: a study among Hong Kong and Hangzhou undergraduates.

    Science.gov (United States)

    Yue, Xiao Dong; Wong, Ashley Yuen Man; Hiranandani, Neelam Arjan

    2014-08-01

    This study examined the relationship between humor styles and loneliness among a sample of Hong Kong and Mainland Chinese. A total of 159 Hong Kong undergraduates and 178 Hangzhou undergraduates were recruited to complete a survey composed of the Humor Styles Questionnaire and the Emotional and Social Loneliness Scales. Multiple regression analyses showed that self-defeating humor explained significant variance in both social and emotional loneliness for Hong Kong students, but only in social loneliness for Hangzhou students. Hong Kong students scored significantly higher on aggressive humor and self-defeating humor, and scored significantly lower on affiliative humor and self-enhancing humor than did their counterparts in Hangzhou. This could be attributed to the greater influence of Confucianism in Mainland China than in Hong Kong.

  4. Post-Umbrella Movement: Localism and Radicalness of the Hong Kong Student Movement

    Directory of Open Access Journals (Sweden)

    Che-po Chan

    2016-08-01

    Full Text Available Hong Kong student movements before the Umbrella Movement showed a political outlook of voicing within norm of the establishment, using “peaceful, rational and non-violent” approaches, acknowledging the authorities of the Hong Kong Special Administrative Region (HKSAR and mainland Chinese governments and recognizing attachment to the motherland China. Today’s new emerging political outlook of the Hong Kong student movement has a profile of anti-establishment, using more assertive means and not excluding radical behaviour, distrust of the HKSAR and mainland authorities and assertion of radical localism. In the last two years, Hong Kong students have undergone a rapid change in their orientation, resulting in today’s outlook. This paper argues that the Umbrella Movement is the key for the turnaround and it testifies to the birth of a new social and political consciousness amongst Hong Kong students.

  5. Protection level of AI H5N1 vaccine clade 2.1.3 commercial against AI H5N1 clade 2.3.2 virus from Ducks to SPF chicken in laboratory conditions

    Directory of Open Access Journals (Sweden)

    Indriani R

    2015-03-01

    Full Text Available Highly Pathogenic Avian Influenza (HPAI subtype H5N1 clade 2.3.2 has infected chickens in farms, causing mortality and a decrease in egg production. Vaccination is one of the strategies to control disease of AI subtype H5N1. AI H5N1 clade 2.1.3 vaccine is available commercially. The effectiveness of two vaccines of AI H5N1 clade 2.1.3 (product A and B, and AI H5N1 clade 2.3.2 (Sukoharjo against AI H5N1 clade 2.3.2 (Sukoharjo virus SPF chickens was tested in laboratory. Four groups of SPF chickens were used in this study, there were (1 vaccinated with H5N1 clade 2.1.3 (product A, (2 vaccinated with H5N1 clade 2.1.3 (product B, (3 vaccinated with AI H5N1 clade 2.3.2 and (4 unvaccinated (as a control. Each vaccinated group consisted of 10 chicken except 8 chicken for control group. SPF chicken were vaccinated with 1 dose of vaccine at 3 weeks olds, and then after 3 weeks post vaccination (at 6 weeks olds. All group of chicken were challenged with 106 EID50 per 0.1 ml via intranasal. The results showed, chicken vaccinated with H5N1 clade 2.1.3 product A and B gave 100 and 80% protection respectively, but showed challenged virus shedding, whereas vaccine of H5N1 clade 2.3.2 gave 100% protection from mortality and without virus shedding. Vaccines of AI H5N1 clade 2.1.3 product A was better than vaccine product B, and when chicken vaccinated against H5N1 clade 2.3.2, H5N1 clade 2.3.2 vaccine was the best to be used. In order to protect chicken from AI subtype H5N1 clade 2.1.3 and 2.3.2 in the field, a bivalent vaccine of H5N1 clade 2.1.3 and 2.3.2 subtypes should be developed.

  6. 人感染高致病性禽流感A/H5N1研究现状%Current opinions in highly pathogenic avian influenza A/HSN1 infection in human being

    Institute of Scientific and Technical Information of China (English)

    李佳; 高占成

    2009-01-01

    The avian influenza virus A/HSN1, known to infect only birds previously, broke the species-interface to infect human beings in Hong Kong in 1997. In the 21st century,highly pathogenic avian influenza viruse A/H5N1 is unprecedently spreading to the continents of Asia, Middle East and Africa, involving 15 countries. The mortality is over 60% and this incidence raises universally,concerning about the possibility that such an influenza virus might become the next influenza pandemic strain. This review summarizes the current opinions of avian influenza A/H5N1 with emphasis on virology, epidemiology, pathology and pathogenesis.%1997年,在香港发生禽流感病毒A/HSNl首次突破种间屏障感染人类的病例.21世纪以来,A/HSN1亚型高致病性禽流感疫情的传播范围、规模以及蔓延速度达到了前所未有的程度.世界上许多国家受到冲击,世界范围内病死率超过60%.鉴于目前全球可能出现新一次流感大流行的严峻形势,加强人禽流感的研究迫在眉睫.本文就人禽流感的病毒研究、流行病学特征、病理改变、发病机制等方面进展进行简要综述.

  7. Relationship between Vision and Visual Perception in Hong Kong Preschoolers.

    Science.gov (United States)

    Ho, Wing-Cheung; Tang, Minny Mei-Miu; Fu, Ching-Wah; Leung, Ka-Yan; Pang, Peter Chi-Kong; Cheong, Allen Ming-Yan

    2015-05-01

    Although superior performance in visual motor and visual perceptual skills of preschool children has been documented in the Chinese population, a normative database is only available for the US population. This study aimed to determine the normative values for these visuomotor and visual perceptual tests for preschool children in the Hong Kong Chinese population and to investigate the effect of fundamental visual functions on visuomotor and visual perceptual skills. One hundred seventy-four children from six different kindergartens in Hong Kong were recruited. Distance visual acuity, near visual acuity, and stereopsis were tested, along with two measures of visual perception (VP): Visual-Motor Integration (VMI) and Test of Visual-Perceptual Skills (TVPS). Raw VMI and TVPS scores were converted into standard/scaled scores. The impact of basic visual functions on VP (VMI and TVPS) was examined using multiple regression. Visual functions were generally good: only 9.2 and 4.6% of subjects had unilateral and bilateral reduced habitual vision, respectively (distance visual acuity in the better eye >0.3 logMAR [logarithm of the minimum angle of resolution]). Performance in the VMI and in the visual memory and spatial relationships subtests of the TVPS exceeded that reported for age-matched children from the United States. Multiple regression analysis provided evidence that age had the strongest predictive value for the VMI and VP skills. In addition, near visual acuity was weakly associated with performance in the VMI and the visual discrimination and spatial relationships subtests of the TVPS, accounting for a limited proportion of the intersubject variability (R VMI and visual memory/spatial relationships of TVPS subtests, perhaps attributed to greater exposure to such material during their preschool home education. This study provided normality data for VMI and four subtests of the TVPS for Hong Kong Chinese preschool children as a reference for future studies.

  8. Submarine Groundwater Discharge into Tolo Harbor, Hong Kong, China

    Science.gov (United States)

    Jiao, J. J.

    2008-12-01

    Tolo Harbor is an elongate and semi-enclosed bay in igneous rock areas in northeastern Hong Kong. It has an area of about 50 km2 and the groundwater catchment behind the harbor has an area of 160 km2, which is well-defined by ridges that reach a maximum elevation of 957 m above sea level. Over the last two decades, about half of the algal blooms reported in Hong Kong waters occurred in the harbor. Rivers and sewage are recognized as two key sources of nutrients. It is speculated that this harbor may have relatively high submarine groundwater discharge (SGD) due to its special topographical and hydrogeological setting and that the SGD may be another source of nutrients to the harbor. A research project is conduced to quantify the SGD into Tolo Harbor and to estimate the nutrient flux into the harbor through this pathway. The geochemical tracers of radon (222Rn) and radium (223Ra, 224Ra, 226Ra, and 228Ra) in groundwater and seawater are measured over the harbor and a seepage meter is deployed for direct and continuous SGD measurement for 72 hours. The study shows that the geochemical tracers fluctuate temporally in anti-phase with tidal height and that there is general trend for the geochemical tracers to decrease with distance offshore. Three sites with relatively high SGD are identified. The residence time estimated from 224Ra is around 30 days, which correlates well with previous studies. The flux of SGD to the harbor is estimated by three different approaches including radium and radon budget analyses and seepage meter. Finally, nutrient flux to the harbor through SGD is estimated, which shows that the nutrient loading through this pathway is significant. It is suggested that current practice for the management of algal blooms in Hong Kong, in which nutrient loading through SGD is ignored, should be reviewed and the control measures of groundwater contamination are obviously required.

  9. Organochlorine insecticides in mudflats of Hong Kong, China.

    Science.gov (United States)

    Wong, H L; Giesy, J P; Lam, P K S

    2006-02-01

    Organochlorine (OC) insecticides were measured in different environmental compartments (including seawater, sediment, and biota) at six sites within the Mai Po Marshes Nature Reserve (MPMNR) and at one site in A Chau (AC) in Hong Kong in June 2002 (wet season) and January 2003 (dry season). MPMNR is a Wetland of International Importance (Ramsar site) situated in the western part of Hong Kong, whereas AC is a relatively remote island in Starling Inlet on the eastern side of the New Territories of Hong Kong. Generally, concentrations of OC insecticides in water, sediment, and biota were greater at MPMNR than at AC. Hexachlorobenzene, dichloro-diphenyl-trichloroethane, and hexachlorocyclohexanes were detected in all samples collected from MPMNR. Preliminary risk assessments were performed by comparing the measured concentrations of OCs in different environmental compartments with the corresponding guidelines promulgated by various environmental protection authorities. Concentrations of some OCs in sediments from certain locations in MPMNR were consistently greater than their corresponding sediment guideline values. These results suggest that the sediment OC concentrations in the sediments of MPMNR might pose a risk to aquatic organisms. Despite this, concentrations of OCs in biota samples were much lower than the relevant guideline values promulgated by government agencies to protect the health of human consumers. It is postulated that the management practices adopted at MPMNR have been effective in limiting the bioaccumulation window (duration) for OCs. This situation may have been aided by a frequent exchange of water between the tidal shrimp ponds at MPMNR and the open sea, again attributable to management practices. The low-cost maintenance practices adopted at MPMNR may potentially be applicable to wetlands in other southeastern Asian countries, thus allowing sustainable fishery production and wildlife conservation.

  10. Benchmarking Hong Kong and China energy codes for residential buildings

    Energy Technology Data Exchange (ETDEWEB)

    Lee, W.L.; Chen, Hua [The Department of Building Services Engineering, Hong Kong Polytechnic University, Hung Hom (China)

    2008-07-01

    Mandatory energy codes to curb energy use of residential buildings have been formally launched in China for more than two decades but little has been publicized in literature. Similar codes are not available for residential buildings in Hong Kong, but most residential buildings in Hong Kong, especially public housing estates, are HK-BEAM certified to demonstrate their compliance with regulatory and basic design requirements. Given HK-BEAM is internationally recognized and there are doubts about the effectiveness of the China codes, how the energy efficiency of the HK-BEAM certified buildings compare with buildings in compliance with the China codes is of interest to most building designers and policy makers. This paper describes how the energy efficiency of a case study building in compliance with the China codes compare with the one in compliance with HK-BEAM. The energy simulation by HTB2 and BECRES reveal that the case study building in compliance with the China codes is 51.1% better in energy use. In the study, the relative impact of each compliance criterion on energy use and cooling load has been quantified by sensitivity analysis. The sensitivity values indicate that energy use is most sensitive to air-conditioning operation hours, indoor design temperature, coefficient of performance (COP) of the room air-conditioners (RAC) units, and the envelop characteristics. The results of this study indicate that a HK-BEAM certified building cannot satisfy the China codes requirements. This provides good reference to the policy makers, the building owners, and to the China and Hong Kong Governments when considering reciprocal recognition of building energy codes. (author)

  11. Health Profile of Construction Workers in Hong Kong.

    Science.gov (United States)

    Yi, Wen; Chan, Albert

    2016-12-13

    Construction is a manual, heavy, and complex sector concerning the most fatal accidents and high incidence of occupational illnesses and injuries resulting in days away from work. In Hong Kong, "Pilot Medical Examination Scheme for Construction Workers" was launched in 2014 to detect the health problems of their construction workforce. All registered workers under the Construction Workers Registration Board are eligible to join the scheme. The purpose of this paper is to assess the physical condition, physiological status, and musculoskeletal disorders of 942 construction workers in Hong Kong. This study adopted a two-phase design, which includes a basic medical examination to measure the workers' physiological parameters, such as blood pressure, resting heart rate, glucose, cholesterol, uric acid, liver function test, and renal function test; as well as a face-to-face interview following the medical examination to collect their demographic information and pain experience. Individual characteristics, including gender, age, obesity, alcohol drinking habit, and sleeping habit influenced the health condition of construction workers. Among the participants, 36.1% and 6.5% of them were overweight and obese, respectively. In addition, 43.0%, 38.4%, 16.2%, and 13.9% of the participants exceeded the thresholds of cholesterol, blood pressure, urea nitrogen, and uric urea, correspondingly. Moreover, 41.0% of the participants suffered musculoskeletal pain, where the most frequent painful parts occur in the lower back, shoulder, knees, leg, and neck. Through these findings, a series of important issues that need to be addressed is pointed out in terms of maintaining the physical well-being and reducing musculoskeletal disorders of construction workers. The finding may have implications for formulating proper intervention strategies for the sustainable development of Hong Kong's construction industry.

  12. Postgraduate education for Chinese medicine practitioners: a Hong Kong perspective

    Directory of Open Access Journals (Sweden)

    Mercer Stewart W

    2009-02-01

    Full Text Available Abstract Background Despite Hong Kong government's official commitment to the development of traditional Chinese medicine (TCM over the last ten years, there appears to have been limited progress in public sector initiated career development and postgraduate training (PGT for public university trained TCM practitioners. Instead, the private TCM sector is expected to play a major role in nurturing the next generation of TCM practitioners. In the present study we evaluated TCM graduates' perspectives on their career prospects and their views regarding PGT. Method Three focus group discussions with 19 local TCM graduates who had worked full time in a clinical setting for fewer than 5 years. Results Graduates were generally uncertain about how to develop their career pathways in Hong Kong with few postgraduate development opportunities; because of this some were planning to leave the profession altogether. Despite their expressed needs, they were dissatisfied with the current quality of local PGT and suggested various ways for improvement including supervised practice-based learning, competency-based training, and accreditation of training with trainee involvement in design and evaluation. In addition they identified educational needs beyond TCM, in particular a better understanding of western medicine and team working so that primary care provision might be more integrated in the future. Conclusion TCM graduates in Hong Kong feel let down by the lack of public PGT opportunities which is hindering career development. To develop a new generation of TCM practitioners with the capacity to provide quality and comprehensive care, a stronger role for the government, including sufficient public funding, in promoting TCM graduates' careers and training development is suggested. Recent British and Australian experiences in prevocational western medicine training reform may serve as a source of references when relevant program for TCM graduates is planned in

  13. Occupational stress and burnout among Hong Kong dentists.

    Science.gov (United States)

    Choy, H B; Wong, M C

    2017-08-25

    Professional burnout has been described as a gradual erosion of a person and may be one of the possible consequences of chronic occupational stress. Although occupational stress has been surveyed among dentists in Hong Kong, no study has been published about burnout in the profession. This study aimed to evaluate burnout among Hong Kong dentists and its association with occupational stress. We surveyed a random sample of 1086 registered dentists in Hong Kong, which formed 50% of the local profession. They were mailed an anonymous questionnaire about burnout and occupational stress in 2015. The questionnaire assessed occupational stress, coping strategies, effects of stress, level of burnout, and socio-demographic characteristics of the respondents. Occupational stress assessment concerned 33 stressors in five groups: patient-related, time-related, income-related, job-related, and staff-/technically related. Level of burnout was assessed by the Maslach Burnout Inventory-Human Services Survey (22 items) with three scores: emotional exhaustion, depersonalisation, and personal accomplishment. Completed questionnaires were received from 301 dentists (response rate, 28.3%), of whom 25.4% had a high level of emotional exhaustion, 17.2% had a high level of depersonalisation, and 39.0% had a low level of personal accomplishment. Only 7.0% of respondents, however, had a high level of overall burnout (high emotional exhaustion, high depersonalisation, and low personal accomplishment). A high level of overall burnout was significantly associated with a higher mean score for job-related stressors and lack of postgraduate qualifications (Pburnout. There was a positive association between occupational stress and level of burnout.

  14. Hemagglutinin pseudotyped lentiviral particles: characterization of a new method for avian H5N1 influenza sero-diagnosis.

    OpenAIRE

    Nefkens, Isabelle; Garcia, Jean-Michel; Ling, Chu Shui; Lagarde, Nadège; Nicholls, John; Tang, Dong Jiang; Peiris, Malik; Buchy, Philippe; Altmeyer, Ralf

    2007-01-01

    BACKGROUND: Highly pathogenic avian influenza (HPAI) H5N1 has spread globally in birds and infected over 270 humans with an apparently high mortality rate. Serologic studies to determine the extent of asymptomatic H5N1 infection in humans and other mammals and to investigate the immunogenicity of current H5N1 vaccine candidates have been hampered by the biosafety requirements needed for H5N1 micro-neutralization tests. OBJECTIVE: Development of a serodiagnostic tool for highly pathogenic infl...

  15. The primary research on mouse and cat infected with A/Tiger/Harbin/01/2003(H5N1)

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    It was confirmed by WHOthat the H5N1viruses resultedinsevere or fatal respiratory disease inthe majority of infectedpersons,indicatingthat the H5N1viruses had crossedthe species barrier without genetic reassortment with a humanin-fluenza virus.To design more effective strategies for prevention and treatment of H5N1viruses infected,in the presentstudy,we used atiger original HPAIVA/Tiger/Harbin/01/2003(H5N1)propagated by SPFembryonated hen eggs to es-tablishinfected animal model.TCID50of virus was10-8/0·1ml ...

  16. Thue use of Management Contracts for Construction in Hong Kong

    Institute of Scientific and Technical Information of China (English)

    Dr.S.L.Tang

    2002-01-01

    A traditional construction contract requires all detal design works to be completed before tendering and subsequent construction works can commence,and therefor erequires a longer time for project completion.This paper describes a relatively new way of construction procurement using management contracts',which allow design construction overlap,and hence reduce project duration.There are advantages in management contracting,but there are disadvantages too.They are discussed in detal in this paper.Two management contracts executed in Hong Kong are used as case studies to illustrate the said advantages and disadvantages.Conclusion is then made and pssible further research work is alkso suggested.

  17. New Records of Freeliving Marine Nematodes from Hong Kong, China

    Institute of Scientific and Technical Information of China (English)

    ZHOU Hong; ZHANG Zhinan

    2003-01-01

    Six species of new records collected from intertidal mangrove/non-mangrove and subtidal cave sediments during a mangrove ecological study (1998-2001) and a marine cave expedition (2002) in Hong Kong waters are redescribed. These include two enoplids: Anoplostoma viviparum in Anoplostomatidae and Trissonchulus janetae in Ironidae, two chromadorids:Paracomesoma dubium and Actarjania splendens in Comesomatidae, and two monhysterids: Parodontophora marina and Parodontophora c.f. danker in Axonolaimidae. Five of them are the first records from China. Ecological and taxonomic remarks are provided and discussed in comparison with the original descriptions.

  18. Occlusion therapy in amblyopia: an experience from Hong Kong.

    Science.gov (United States)

    Tang, Emily W H; Li, Brian C Y; Yeung, Ian Y L; Li, Kenneth K W

    2014-02-01

    OBJECTIVES. To review the results of patching for amblyopia management in Hong Kong. DESIGN. Retrospective case series. SETTING. Regional hospital, Hong Kong. PATIENTS. Records of all patients attending Paediatric Ophthalmology Clinic at United Christian Hospital, Hong Kong from 1 January 2009 to 31 March 2009 were retrospectively reviewed. Records of all children who underwent patching for amblyopia in the study period were evaluated. RESULTS. The mean age of 50 children (50 eyes) was 4 (standard deviation, 1; range, 2-7) years and mean pretreatment visual acuity was 0.35 (0.15; 0.02-0.63) [~20/60]. The values for mean, standard deviation, and range of treatment duration were 27, 16, 4-67 months respectively, and corresponding values for prescribed patching per day were 4, 1, 2-8 hours. The mean, standard deviation, and range of visual acuity at final post-treatment assessment were 0.66, 0.16, 0.1-1.0 (~20/30), respectively. The overall success rate (ie final visual acuity >0.7 or 20/30) was 62%. Children with moderate amblyopia (20/40-20/80) and severe amblyopia (20/100-20/400) had success rates of 74% and 55%, respectively. The mean visual acuity improvements for moderate and severely amblyopic children were 2.3 lines and 5.8 lines, respectively. The mean, standard deviation, and range of patching prescriptions for moderate and severely amblyopic children were 5, 1, 2-7 hours and 5, 1, 3-6 hours, respectively. Recurrence ensued in 7% of the children with moderate amblyopia and 46% of those with severe amblyopia. Reported compliance was good (>75% of the time) in 68% of the children. CONCLUSION. Occlusion therapy is the mainstay of treatment in Hong Kong. The overall success rate was comparable to that achieved in the Amblyopia Treatment Study. Recurrence was more common in patients with severe amblyopia, for whom maintenance therapy may reduce the risk of recurrence. The duration of treatment was much longer in our locality than in western countries. Reported

  19. Gaming behavior and addiction among Hong Kong adolescents

    OpenAIRE

    Wong, Irene Lai Kuen; Lam, Millicent Pui Sze

    2016-01-01

    Objectives Game playing is very popular among Hong Kong teenagers. This study aimed to investigate adolescent gaming behavior and addiction at the Internet cafe, and to explore perceived benefits and harms associated with the activity. Methods A convenient sample of 13 male high school students aged 12–15 years (mean age = 13.6 years) were interviewed at two Internet cafes. Young’s (Caught in the net, Wiley, New York, 1998) criteria of Internet addiction were modified to assess gaming addicti...

  20. Gaming behavior and addiction among Hong Kong adolescents

    OpenAIRE

    Irene Lai Kuen Wong; Millicent Pui Sze Lam

    2016-01-01

    Abstract Objectives Game playing is very popular among Hong Kong teenagers. This study aimed to investigate adolescent gaming behavior and addiction at the Internet cafe, and to explore perceived benefits and harms associated with the activity. Methods A convenient sample of 13 male high school students aged 12–15 years (mean age = 13.6 years) were interviewed at two Internet cafes. Young’s (Caught in the net, Wiley, New York, 1998) criteria of Internet addiction were modified to assess gamin...

  1. Hong kong working class and union organization: A historical glimpse

    OpenAIRE

    Ng, Sek Hong; Ip, Olivia

    2008-01-01

    This paper attempts to sketch a longitudinal profile on the evolution of a working class in Hong Kong context in light of the thesis of embourgeoisement. The increasing economic affluence in the 1980s and early 1990s appeared to have bred an optimism in society that the members of the working class were converging in life-style and consumption behaviour with the middle class in a process of embourgeoisement. However, the thesis of embourgeoisement comes under question again around the turn of...

  2. On the historical consciousness of Hong Kong students

    OpenAIRE

    Kan, Flora

    2008-01-01

    This study focused on evaluating students' historical consciousness as defined by Jorn Rüsen. Two historical events are used. Students were asked the importance of these historical events to himself/herself and/or to others. The aim is to investigate whether the typology of historical consciousness devised by Rüsen could be applied to Hong Kong, and/or whether there were other possible typologies other than the four types specified by Rüsen. Rüsen's 'traditional' category does not distinctive...

  3. Beijing Kowloon Railway, A Shortcut from Beijing to Hong Kong

    Institute of Scientific and Technical Information of China (English)

    1998-01-01

    At 2,397 kilometers, the Beijing-Kowloon Railway is the shortest line from China’s capital to Kowloon, Hong Kong SAR. On September 1, 1996, the No. 105 train made its debut at the Beijing West Railway Station and started to click along to the other terminal in Shenzhen. At present, five pairs of trains are running on the railway. Technically, the new line was built to alleviate the bottleneck situation of the rail transportation. In addition, it is hoped that the Shenzhen Special Economic Zone can help spur the economies of the

  4. Antiviral polysaccharides isolated from Hong Kong brown seaweed Hydroclathrus clathratus

    Institute of Scientific and Technical Information of China (English)

    WANG; Hui; OOI; Engchoon; Vincent; ANG; Put; O; Jr.

    2007-01-01

    Two relatively pure polysaccharides H3-a1 and H3-b1 had been isolated from the brown seaweed Hydroclathrus clathratus. They were characterized by HPLC, ultraviolet scanning, gas chromatography, infrared spectroscopy and elemental analysis, and shown to be two different sulfated polysaccharides with different monosaccharide content, but both with high relative molecular mass. They contained some proteins and uronic acid respectively. The sulfate content and bioactivity of these polysaccharides varied during purification. The fractions derived from the hot water extract also exhibited low anticoagulant effect. This is the first time that the antiherpetic and anticoagulant activities were evaluated for the polysaccharides from the Hong Kong brown seaweed Hydroclathrus clathratus.

  5. BIODIVERSITY AND CONSERVATION OF FRESHWATER FISH IN HONG KONG, CHINA

    Institute of Scientific and Technical Information of China (English)

    VIRGINIA; Laifun; Lee; MARIA; Lauching; Young; TONY; Kingtung; Chan; SAMUEL; Kinsan; Lam; FRANCO; Kwokyan; Ng; JULIA; Wingyin; Chan

    2006-01-01

    Hong Kong Special Administrative Region,China,has an area of1095km2and is located at the edge of thenorthern tropical zone.The landscape is dominated byhills and ravines withflat landrestrictedtothe lowflood-plains and coastal regions.Inthis hilly domain,the smallrocky streams are typically fast flowing at their uplandsources,and graduallyreduceinspeed asthey wind alonghill cuttings to reach the lowlands.While streams arecommonlyfound,rivers are very limited in number.Thefewlong and meandering rivers with t...

  6. Hong Kong China Gas Makes Huge Investment in Wuhan

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    @@ Hong Kong China Gas (0003HK) will invest HK$500 million for construction of gas pipeline network in Wuhan City. The company has selected Wuhan Gas Thermal Group, the largest gas supplier in the city, as its cooperation partner. This is the largest investment China Gas has made for construction of urban pipeline network in the inland cities. Wuhan, as important city in Central China with millions of people, is the first large city in the inland area which China Gas has established its business presence.

  7. Evidence for subclinical H5N1 avian influenza infections among Nigerian poultry workers.

    Science.gov (United States)

    Okoye, John O; Eze, Didacus C; Krueger, Whitney S; Heil, Gary L; White, Sarah K; Merrill, Hunter R; Gray, Gregory C

    2014-12-01

    In recent years Nigeria has experienced sporadic incursions of highly pathogenic H5N1 avian influenza among poultry. In 2008, 316 poultry-exposed agricultural workers, and 54 age-group matched non-poultry exposed adults living in the Enugu or Ebonyi States of Nigeria were enrolled and then contacted monthly for 24 months to identify acute influenza-like-illnesses. Annual follow-up sera and questionnaire data were collected at 12 and 24 months. Participants reporting influenza-like illness completed additional questionnaires, and provided nasal and pharyngeal swabs and acute and convalescent sera. Swab and sera specimens were studied for evidence of influenza A virus infection. Sera were examined for elevated antibodies against 12 avian influenza viruses by microneutralization and 3 human viruses by hemagglutination inhibition. Four (3.2%) of the 124 acute influenza-like-illness investigations yielded molecular evidence of influenza, but virus could not be cultured. Serial serum samples from five poultry-exposed subjects had a ≥4-fold change in microneutralization titers against A/CK/Nigeria/07/1132123(H5N1), with three of those having titers ≥1:80 (maximum 1:1,280). Three of the five subjects (60%) reported a preceding influenza-like illness. Hemagglutination inhibition titers were ≥4-fold increases against one of the human viruses in 260 participants. While cross-reactivity from antibodies against other influenza viruses cannot be ruled out as a partial confounder, over the course of the 2-year follow-up, at least 3 of 316 (0.9%) poultry-exposed subjects had evidence for subclinical HPAI H5N1 infections. If these data represent true infections, it seems imperative to increase monitoring for avian influenza among Nigeria's poultry and poultry workers.

  8. Purification of neuraminidase from Influenza virus subtype H5N1

    Directory of Open Access Journals (Sweden)

    Simson Tariga

    2009-03-01

    Full Text Available Influenza-virus neuraminidase plays vital role in the survival of the organisms. Vaccination of animals with this glycoprotein confers immune responses so that enable it to protect the animals from incoming infection. Supplementation of conventional vaccines with this glycoprotein increases the protection and longevity of the vaccine. Purified neuraminidase can also be used to develop serological tests for differentiation of serologically positive animals due to infection or to vaccination. In this study purification of neuraminidase from influenza virus subtype H5N1 was described. Triton x-100 and Octyl β-D-glucopyranoside were used to extract and diluted the glycoprotein membrane. The enzymatic activity of the neuraminidase was assayed using a fluorochrome substrate, 4-methylumbelliferyl-a-D-N-acetyl neuraminic acid, which was found to be simple, sensitive and suitable for the purification purpose. The neuraminidase was absorbed selectively on an oxamic-acid agarose column. The purity of neuraminidase eluted from this affinity column was high. A higher purity of the neuraminidase was obtained by further separation with gel filtration on Superdex-200. The purified neuraminidase was enzymatically active and did not contain any detectable haemagglutinin, either by haemagglutination assay or by monospecific antibodies raised against H5N1 hemagglutinin. The purified neuraminidase was recognized strongly by antibodies raised against an internal but only weakly by that against C-terminal regions of the neuraminidase protein of H5N1-influenza virus. The purified neuraminidase was in tetrameric forms but dissociated into monomeric form on reducing condition, or mostly dimeric form on non-reducing SDS-PAGE.

  9. New strategies for the development of H5N1 subtype influenza vaccines: progress and challenges.

    Science.gov (United States)

    Steel, John

    2011-10-01

    The emergence and spread of highly pathogenic avian influenza (H5N1) viruses among poultry in Asia, the Middle East, and Africa have fueled concerns of a possible human pandemic, and spurred efforts towards developing vaccines against H5N1 influenza viruses, as well as improving vaccine production methods. In recent years, promising experimental reverse genetics-derived H5N1 live attenuated vaccines have been generated and characterized, including vaccines that are attenuated through temperature-sensitive mutation, modulation of the interferon antagonist protein, or disruption of the M2 protein. Live attenuated influenza virus vaccines based on each of these modalities have conferred protection against homologous and heterologous challenge in animal models of influenza virus infection. Alternative vaccine strategies that do not require the use of live virus, such as virus-like particle (VLP) and DNA-based vaccines, have also been vigorously pursued in recent years. Studies have demonstrated that influenza VLP vaccination can confer homologous and heterologous protection from lethal challenge in a mouse model of infection. There have also been improvements in the formulation and production of vaccines following concerns over the threat of H5N1 influenza viruses. The use of novel substrates for the growth of vaccine virus stocks has been intensively researched in recent years, and several candidate cell culture-based systems for vaccine amplification have emerged, including production systems based on Madin-Darby canine kidney, Vero, and PerC6 cell lines. Such systems promise increased scalability of product, and reduced reliance on embryonated chicken eggs as a growth substrate. Studies into the use of adjuvants have shown that oil-in-water-based adjuvants can improve the immunogenicity of inactivated influenza vaccines and conserve antigen in such formulations. Finally, efforts to develop more broadly cross-protective immunization strategies through the inclusion

  10. Highly pathogenic avian influenza (H5N1: pathways of exposure at the animal-human interface, a systematic review.

    Directory of Open Access Journals (Sweden)

    Maria D Van Kerkhove

    Full Text Available BACKGROUND: The threat posed by highly pathogenic avian influenza A H5N1 viruses to humans remains significant, given the continued occurrence of sporadic human cases (499 human cases in 15 countries with a high case fatality rate (approximately 60%, the endemicity in poultry populations in several countries, and the potential for reassortment with the newly emerging 2009 H1N1 pandemic strain. Therefore, we review risk factors for H5N1 infection in humans. METHODS AND FINDINGS: Several epidemiologic studies have evaluated the risk factors associated with increased risk of H5N1 infection among humans who were exposed to H5N1 viruses. Our review shows that most H5N1 cases are attributed to exposure to sick poultry. Most cases are sporadic, while occasional limited human-to-human transmission occurs. The most commonly identified factors associated with H5N1 virus infection included exposure through contact with infected blood or bodily fluids of infected poultry via food preparation practices; touching and caring for infected poultry; [corrected] exposure to H5N1 via swimming or bathing in potentially virus laden ponds; and exposure to H5N1 at live bird markets. CONCLUSIONS: Research has demonstrated that despite frequent and widespread contact with poultry, transmission of the H5N1 virus from poultry to humans is rare. Available research has identified several risk factors that may be associated with infection including close direct contact with poultry and transmission via the environment. However, several important data gaps remain that limit our understanding of the epidemiology of H5N1 in humans. Although infection in humans with H5N1 remains rare, human cases continue to be reported and H5N1 is now considered endemic among poultry in parts of Asia and in Egypt, providing opportunities for additional human infections and for the acquisition of virus mutations that may lead to more efficient spread among humans and other mammalian species

  11. Traumatic Brain Injury Rehabilitation in Hong Kong: A Review of Practice and Research

    Directory of Open Access Journals (Sweden)

    Junhong Yu

    2015-01-01

    Full Text Available Background. The rising public health concern regarding traumatic brain injury (TBI implies a growing need for rehabilitation services for patients surviving TBI. Methods. To this end, this paper reviews the practices and research on TBI rehabilitation in Hong Kong so as to inform future developments in this area. This paper begins by introducing the general situation of TBI patients in Hong Kong and the need for rehabilitation. Next, the trauma system in Hong Kong is introduced. Following that is a detailed description of the rehabilitation services for TBI patients in Hong Kong, as exemplified by a rehabilitation hospital in Hong Kong. This paper will also review intervention studies on rehabilitating brain-injured populations in Hong Kong with respect to various rehabilitation goals. Lastly, the implications of culture-related issues will be discussed in relation to TBI. Results/Conclusions. The intervention studies conducted in Hong Kong are generally successful in achieving various rehabilitative outcomes. Additionally, certain cultural-related issues, such as the stigma associated with TBI, may impede the rehabilitative process and lead to various psychosocial problems.

  12. Design of new inhibitors for H5N1 avian influenza using a molecular dynamics simulation

    Science.gov (United States)

    Park, Jin Woo; Jo, Won Ho

    2008-03-01

    Recently, there has been a growing interest in the treatment of H5N1 avian influenza. One of the most widely used antiviral agents is oseltamivir. However, it has been reported that oseltamivir is not as effective against the neuraminidase subtype N1 as it is against subtypes N2 and N9. In our research we addressed this problem by designing new inhibitors and these altered inhibitor's binding affinities were calculated. In this study, we introduced chemical groups to the existing oseltamivir, so to fit into the newly discovered cavity in the subtype N1. When the binding strengths of the oseltamivir and the newly designed inhibitors for N1 were calculated to examine the drug efficiency through a molecular dynamics simulation, then compared with each other, it was found that one of the designed molecules exhibited a strong binding affinity, with more than twice the binding strength than that of oseltamivir. Since the aforementioned designed inhibitor appears to have the possibility for oral activity according to the criteria of human oral bioavailability, we propose that the inhibitor is a promising antiviral drug for H5N1 avian influenza.

  13. Genome Analysis Linking Recent European and African Influenza (H5N1) Viruses

    Science.gov (United States)

    Kingsford, Carl; Cattoli, Giovanni; Spiro, David J.; Janies, Daniel A.; Aly, Mona Mehrez; Brown, Ian H.; Couacy-Hymann, Emmanuel; De Mia, Gian Mario; Dung, Do Huu; Guercio, Annalisa; Joannis, Tony; Ali, Ali Safar Maken; Osmani, Azizullah; Padalino, Iolanda; Saad, Magdi D.; Savić, Vladimir; Sengamalay, Naomi A.; Yingst, Samuel; Zaborsky, Jennifer; Zorman-Rojs, Olga; Ghedin, Elodie; Capua, Ilaria

    2007-01-01

    To better understand the ecology and epidemiology of the highly pathogenic avian influenza virus in its transcontinental spread, we sequenced and analyzed the complete genomes of 36 recent influenza A (H5N1) viruses collected from birds in Europe, northern Africa, and southeastern Asia. These sequences, among the first complete genomes of influenza (H5N1) viruses outside Asia, clearly depict the lineages now infecting wild and domestic birds in Europe and Africa and show the relationships among these isolates and other strains affecting both birds and humans. The isolates fall into 3 distinct lineages, 1 of which contains all known non-Asian isolates. This new Euro-African lineage, which was the cause of several recent (2006) fatal human infections in Egypt and Iraq, has been introduced at least 3 times into the European-African region and has split into 3 distinct, independently evolving sublineages. One isolate provides evidence that 2 of these sublineages have recently reassorted. PMID:17553249

  14. Avian Influenza H5N1 and the Wild Bird Trade in Hanoi, Vietnam

    Directory of Open Access Journals (Sweden)

    F. Brooks-Moizer

    2009-06-01

    Full Text Available Wildlife trade and emerging infectious diseases pose significant threats to human and animal health and global biodiversity. Legal and illegal trade in domestic and wild birds has played a significant role in the global spread of highly pathogenic avian influenza H5N1, which has killed more than 240 people, many millions of poultry, and an unknown number of wild birds and mammals, including endangered species, since 2003. This 2007 study provides evidence for a significant decline in the scale of the wild bird trade in Hanoi since previous surveys in 2000 (39.7% decline and 2003 (74.1% decline. We attribute this to the enforcement of Vietnam's Law 169/2005/QD UBND, introduced in 2005, which prohibits the movement and sale of wild and ornamental birds in cities. Nevertheless, 91.3% (21/23 of bird vendors perceived no risk of H5N1 infection from their birds, and the trade continues, albeit at reduced levels, in open market shops. These findings highlight the importance of continued law enforcement to maintain this trade reduction and the associated benefits to human and animal health and biodiversity conservation.

  15. Avian influenza H5N1 virus infections in vaccinated commercial and backyard poultry in Egypt.

    Science.gov (United States)

    Hafez, M H; Arafa, A; Abdelwhab, E M; Selim, A; Khoulosy, S G; Hassan, M K; Aly, M M

    2010-08-01

    In this paper, we describe results from a high-pathogenic H5N1 avian influenza virus (AIV) surveillance program in previously H5-vaccinated commercial and family-backyard poultry flocks that was conducted from 2007 to 2008 by the Egyptian National Laboratory for Veterinary Quality Control on Poultry Production. The real-time reverse transcription PCR assay was used to detect the influenza A virus matrix gene and detection of the H5 and N1 subtypes was accomplished using a commercially available kit real-time reverse transcription PCR assay. The virus was detected in 35/3,610 (0.97%) and 27/8,682 (0.31%) of examined commercial poultry farms and 246/816 (30%) and 89/1,723 (5.2%) of backyard flocks in 2007 and 2008, respectively. Positive flocks were identified throughout the year, with the highest frequencies occurring during the winter months. Anti-H5 serum antibody titers in selected commercial poultry ranged from poultry in Egypt to combat H5N1 AIV, continuous circulation of the virus in vaccinated commercial and backyard poultry was reported and the efficacy of the vaccination using a challenge model with the current circulating field virus should be revised.

  16. Metapopulation dynamics enable persistence of influenza A, including A/H5N1, in poultry.

    Directory of Open Access Journals (Sweden)

    Parviez Rana Hosseini

    Full Text Available Highly pathogenic influenza A/H5N1 has persistently but sporadically caused human illness and death since 1997. Yet it is still unclear how this pathogen is able to persist globally. While wild birds seem to be a genetic reservoir for influenza A, they do not seem to be the main source of human illness. Here, we highlight the role that domestic poultry may play in maintaining A/H5N1 globally, using theoretical models of spatial population structure in poultry populations. We find that a metapopulation of moderately sized poultry flocks can sustain the pathogen in a finite poultry population for over two years. Our results suggest that it is possible that moderately intensive backyard farms could sustain the pathogen indefinitely in real systems. This fits a pattern that has been observed from many empirical systems. Rather than just employing standard culling procedures to control the disease, our model suggests ways that poultry production systems may be modified.

  17. Intranasal Immunization of Mice to Avoid Interference of Maternal Antibody against H5N1 Infection.

    Directory of Open Access Journals (Sweden)

    Fenghua Zhang

    Full Text Available Maternally-derived antibodies (MDAs can protect offspring against influenza virus infection but may also inhibit active immune responses. To overcome MDA- mediated inhibition, active immunization of offspring with an inactivated H5N1 whole-virion vaccine under the influence of MDAs was explored in mice. Female mice were vaccinated twice via the intraperitoneal (IP or intranasal (IN route with the vaccine prior to mating. One week after birth, the offspring were immunized twice via the IP or IN route with the same vaccine and then challenged with a lethal dose of a highly homologous virus strain. The results showed that, no matter which immunization route (IP or IN was used for mothers, the presence of MDAs severely interfered with the active immune response of the offspring when the offspring were immunized via the IP route. Only via the IN immunization route did the offspring overcome the MDA interference. These results suggest that intranasal immunization could be a suitable inoculation route for offspring to overcome MDA interference in the defense against highly pathogenic H5N1 virus infection. This study may provide references for human and animal vaccination to overcome MDA-induced inhibition.

  18. Internet Addiction Phenomenon in Early Adolescents in Hong Kong

    Directory of Open Access Journals (Sweden)

    Daniel T. L. Shek

    2012-01-01

    Full Text Available The present study investigated the prevalence and demographic correlates of Internet addiction in Hong Kong adolescents as well as the change in related behavior at two time points over a one-year interval. Two waves of data were collected from a large sample of students (Wave 1: 3,328 students, age =12.59±0.74 years; Wave 2: 3,580 students, age =13.50±0.75 years at 28 secondary schools in Hong Kong. Comparable to findings at Wave 1 (26.4%, 26.7% of the participants met the criterion of Internet addiction at Wave 2 as measured by Young’s 10-item Internet Addiction Test. The behavioral pattern of Internet addiction was basically stable over time. While the predictive effects of demographic variables including age, gender, family economic status, and immigration status were not significant, Internet addictive behaviors at Wave 1 significantly predicted similar behaviors at Wave 2. Students who met the criterion of Internet addiction at Wave 1 were 7.55 times more likely than other students to be classified as Internet addicts at Wave 2. These results suggest that early detection and intervention for Internet addiction should be carried out.

  19. Internet addiction phenomenon in early adolescents in Hong Kong.

    Science.gov (United States)

    Shek, Daniel T L; Yu, Lu

    2012-01-01

    The present study investigated the prevalence and demographic correlates of Internet addiction in Hong Kong adolescents as well as the change in related behavior at two time points over a one-year interval. Two waves of data were collected from a large sample of students (Wave 1: 3,328 students, age = 12.59 ± 0.74 years; Wave 2: 3,580 students, age = 13.50 ± 0.75 years) at 28 secondary schools in Hong Kong. Comparable to findings at Wave 1 (26.4%), 26.7% of the participants met the criterion of Internet addiction at Wave 2 as measured by Young's 10-item Internet Addiction Test. The behavioral pattern of Internet addiction was basically stable over time. While the predictive effects of demographic variables including age, gender, family economic status, and immigration status were not significant, Internet addictive behaviors at Wave 1 significantly predicted similar behaviors at Wave 2. Students who met the criterion of Internet addiction at Wave 1 were 7.55 times more likely than other students to be classified as Internet addicts at Wave 2. These results suggest that early detection and intervention for Internet addiction should be carried out.

  20. Angelman syndrome in Hong Kong Chinese: A 20 years' experience.

    Science.gov (United States)

    Luk, H M; Lo, Ivan F M

    2016-06-01

    AS(OMIM #105830) is a neurodevelopmental disease that characterized by severe intellectual disability, lack of speech, happy disposition, ataxia, epilepsy and distinct behavioural profile. A tertiary wide study was performed in Hong Kong with aim to examine the clinical and molecular features, genotype-phenotype correlation of the Angelman syndrome (AS) patients. There were total 55 molecularly confirmed AS between January 1995 to September 2015 for review. 65.5% of them were caused by maternal microdeletion, 10.9% by paternal uniparental disomy, 3.6% by imprinting center defect and 14.5% by UBE3A gene mutation. Genotype-phenotype correlation showed epilepsy and microcephaly is more common in microdeletion type as compared with non-microdeletional type. We have concluded that the incidence rate, clinical features and underlying genetic mechanisms in Hong Kong Chinese were comparable with other western populations. The overall average age of diagnosis in this cohort was 6.2 years old (95% C.I was 5.0-7.5 years old). It is hope that by increasing awareness and early referral could result in early diagnosis and better management for AS patient. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

  1. Hong Kong architecture 1945-2015 from colonial to global

    CERN Document Server

    Xue, Charlie Q L

    2016-01-01

    This book focuses on the transformation from colonial to global – the formation, mechanism, events, works and people related to urban architecture. The book reveals hardships the city encountered in the 1950s and the glamour enjoyed in the 1980s. It depicts the public and private developments, and especially the public housing which has sheltered millions of residents. The author identifies the architects practising in the formative years and the representatives of a rising generation after the 1980s. Suffering from land shortage and a dense environment, the urban development of Hong Kong has in the past 70 years met the changing demands of fluctuating economic activities and a rising population. Architecture on the island has been shaped by social demands, the economy and technology. The buildings have been forged by the government, clients, planners, architects, many contractors and end-users. The built environment nurtures our life and is visual evidence of the way the city has developed. Hong Kong is a ...

  2. Adolescent Internet Addiction in Hong Kong: Prevalence, Change, and Correlates.

    Science.gov (United States)

    Shek, Daniel T L; Yu, Lu

    2016-02-01

    Prevalence, change, and correlates of adolescent Internet addiction were examined in this study on the basis of six waves of longitudinal data collected over 6 years. DESIGN, SETTING, PARTICIPANTS, INTERVENTIONS, AND MAIN OUTCOME MEASURES: Over 6 years, students responded to a questionnaire containing measures of sociodemographic characteristics, positive youth development, family processes, and Internet addiction behavior. The prevalence rates of Internet addiction in Hong Kong adolescents ranged from 17% to 26.8% during the high school years. Male students consistently showed a higher prevalence rate of Internet addiction and more Internet addictive behaviors than did female students. Longitudinal data suggested that although family economic disadvantage served as a risk factor for youth Internet addiction, the effects of family intactness and family functioning were not significant. Students' overall positive youth development and general positive youth development qualities were negatively related to Internet addictive behaviors and prosocial attributes had a positive relationship with youth Internet addiction. The results suggest that promotion of positive youth development is a promising direction for preventing Internet addiction in Hong Kong adolescents. Gender and family economic disadvantage must be considered in design of the related prevention programs. Copyright © 2016 North American Society for Pediatric and Adolescent Gynecology. Published by Elsevier Inc. All rights reserved.

  3. Internet Addiction Phenomenon in Early Adolescents in Hong Kong

    Science.gov (United States)

    Shek, Daniel T. L.; Yu, Lu

    2012-01-01

    The present study investigated the prevalence and demographic correlates of Internet addiction in Hong Kong adolescents as well as the change in related behavior at two time points over a one-year interval. Two waves of data were collected from a large sample of students (Wave 1: 3,328 students, age = 12.59 ± 0.74 years; Wave 2: 3,580 students, age = 13.50 ± 0.75 years) at 28 secondary schools in Hong Kong. Comparable to findings at Wave 1 (26.4%), 26.7% of the participants met the criterion of Internet addiction at Wave 2 as measured by Young's 10-item Internet Addiction Test. The behavioral pattern of Internet addiction was basically stable over time. While the predictive effects of demographic variables including age, gender, family economic status, and immigration status were not significant, Internet addictive behaviors at Wave 1 significantly predicted similar behaviors at Wave 2. Students who met the criterion of Internet addiction at Wave 1 were 7.55 times more likely than other students to be classified as Internet addicts at Wave 2. These results suggest that early detection and intervention for Internet addiction should be carried out. PMID:22778694

  4. Landslide disaster prevention and mitigation through works in Hong Kong

    Institute of Scientific and Technical Information of China (English)

    K.Y. Choi; Raymond W.M. Cheung

    2013-01-01

    Hong Kong has a high concentration of developments on hilly terrain in close proximity to man-made slopes and natural hillsides. Because of the high seasonal rainfall, these man-made slopes and natural hillsides would pose a risk to the public as manifested by a death toll of 470 people due to landslides since the late 1940s. In 1977, the Government of the Hong Kong SAR embarked on a systematic programme, known as the Landslip Preventive Measure (LPM) Programme, to retrofit substandard man-made slopes. From 1977 to 2010, about 4500 substandard government man-made slopes have been upgraded through engineering works. During the period, the Programme had evolved progressively in response to Gov-ernment’s internal demand for continuous improvement and rising public expectation for slope safety. In 2010, the Government implemented the Landslip Prevention and Mitigation (LPMit) Programme to dovetail with the LPM Programme, with the focus on retrofitting the remaining moderate-risk substan-dard man-made slopes and mitigating systematically the natural terrain landslide risk pursuant to the“react-to-known”hazard principle. This paper presents the evolution of the LPM and LPMit Programmes as well as the insight on landslide prevention and mitigation through engineering works.

  5. Impact Evaluation of Low Flow Showerheads for Hong Kong Residents

    Directory of Open Access Journals (Sweden)

    Ling-tim Wong

    2016-07-01

    Full Text Available The voluntary Water Efficiency Labelling Scheme (WELS on showers for bathing in Hong Kong is a water conservation initiative of the Hong Kong Special Administrative Region (HKSAR Government. As shower water consumption has been identified as a potential area for carbon emissions reductions, this study examines, from a five-month measurement survey of the showering practices of 37 local residents, a range of showerheads with resistance factors k = 0.54–4.05 kPa·min2·L−2 with showering attributes including hot shower temperature, temperature difference between hot and cold water supply, flow rate and water consumption and shower duration. A Monte Carlo model is proposed for evaluating the water consumption and carbon-reducing impacts of WELS on showers for bathing at confidence intervals with input parameters determined from the measurement survey. The simulation results indicate that full implementation of WELS rated showerheads with k ≥ 4.02 can reduce water consumption by 37%, energy use by 25% and carbon dioxide (CO2 emissions by 26%. This study is also a useful source of reference for policymakers and practitioners to evaluate the impacts of water efficient showerheads on water consumption, energy use, and CO2 emissions.

  6. Recent clinical innovations in thoracic surgery in Hong Kong.

    Science.gov (United States)

    Zhao, Ze-Rui; Li, Zheng; Situ, Dong-Rong; Ng, Calvin S H

    2016-08-01

    The concept of personalized medicine, which aims to provide patients with targeted therapies while greatly reducing surgical trauma, is gaining popularity among Asian clinicians. Single port video-assisted thoracic surgery (VATS) has rapidly gained popularity in Hong Kong for major lung resections, despite bringing new challenges such as interference between surgical instruments and insertion of the optical source through a single incision. Novel types of endocutters and thoracoscopes can help reduce the difficulties commonly encountered during single-port VATS. Our region has been the testing ground and has led the development of many of these innovations. Performing VATS, in particular single-port VATS in hybrid operating theatre helps to localise small pulmonary lesions with real-time images, thus increasing surgical accuracy and pushes the boundaries in treating subcentimeter diseases. Such approach may be assisted by use of electromagnetic navigational bronchoscopy in the same setting. In addition, sublobar resection can also be more individualised according to pathologic tumour subtype that require rapid intraoperative diagnostic test to guide appropriate surgical therapy. A focus on technology and innovation for large tumours that require chest wall resection and reconstructions have also been on going, with new materials and prostheses that may be tailored to each individual needs. The current paper reviews the literature pertaining to the above topics and discusses recent related innovations in Hong Kong, highlighting the study results and future perspectives.

  7. First-trimester medical abortion service in Hong Kong.

    Science.gov (United States)

    Lo, Sue S T; Ho, P C

    2015-10-01

    Research on medical abortion has been conducted in Hong Kong since the 1990s. It was not until 2011 that the first-trimester medical abortion service was launched. Mifepristone was registered in Hong Kong in April 2014 and all institutions that are listed in the Gazette as a provider for legal abortion can purchase mifepristone from the local provider. This article aimed to share our 3-year experience of this service with the local medical community. Our current protocol is safe and effective, and advocates 200-mg mifepristone and 400-µg sublingual misoprostol 24 to 48 hours later, followed by a second dose of 400-µg sublingual misoprostol 4 hours later if the patient does not respond. The complete abortion rate is 97.0% and ongoing pregnancy rate is 0.4%. Some minor side-effects have been reported and include diarrhoea, fever, abdominal pain, and allergy. There have been no serious adverse events such as heavy bleeding requiring transfusion, anaphylactic reaction, septicaemia, or death.

  8. Perfluorochemicals in wastewater treatment plants and sediments in Hong Kong

    Energy Technology Data Exchange (ETDEWEB)

    Ma Ruowei [Department of Civil Engineering, University of Hong Kong, Pokfulam Road, Hong Kong (Hong Kong); Shih, Kaimin, E-mail: kshih@hku.h [Department of Civil Engineering, University of Hong Kong, Pokfulam Road, Hong Kong (Hong Kong)

    2010-05-15

    The study reported in this paper examined the concentrations of nineteen perfluorochemicals (PFCs), including perfluoroalkyl sulfonates, carboxylates, and sulfonamides in samples collected from Hong Kong wastewater treatment plants (WWTPs) and sediments. The study was the first to use an external isolator column to assist in the quantification of PFCs in environmental samples without having to make internal modifications to a liquid chromatography system. Perfluorooctanesulfonate was found to be the dominant PFC pollutant in Hong Kong, and the WWTP sludge was the major sink of PFCs discharged from the urban areas. Compared to discharge influenced by industrial activities, much less perfluorooctanoate was found in waste streams. The significantly lower level of perfluorodecanesulfonate in WWTP sludge reflects the important influence of consumer products on PFC distribution. The dominance of even-chain length perfluoroalkyl carboxylates in all of the WWTP sludge samples investigated further suggests the strong aerobic degradation of fluorotelomer alcohols in WWTPs. - WWTP sludge is the major sink for PFCs discharged from the urban areas and has a distinctive compound distribution corresponding to its source.

  9. Design of a positive youth development program in Hong Kong.

    Science.gov (United States)

    Shek, Daniel T L; Ma, Hing Keung

    2006-01-01

    The design of a positive youth development program in Hong Kong is outlined. Based on adolescent developmental issues observed in Hong Kong and the conceptual framework on positive youth development, a 2-tier program was designed. For the Tier 1 Program, it is a universal positive youth development program for students in Secondary 1 to Secondary 3 with the curricula developed by a research team comprising scholars from different disciplines (e.g., social work, psychology, and education). For the Tier 2 Program, it is a selective program targeting adolescents with greater psychosocial needs, developed by school social workers providing school social work service in the schools. With particular reference to the Tier 1 program, several principles are maintained in the design of the program. These include comprehensive coverage of positive youth development constructs, theoretical and empirical grounding of the program, holistic emphasis, focus on both adolescent development assets and problems, developmentally appropriate content, culturally relevant content, multi-year intervention, provision of proper and adequate training to the workers, and use of effective teaching methods in the delivery of the program.

  10. Professional nursing values among baccalaureate nursing students in Hong Kong.

    Science.gov (United States)

    Lui, May H L; Lam, Lai Wah; Lee, Iris F K; Chien, Wai Tong; Chau, Janita P C; Ip, Wan Yim

    2008-01-01

    The development of a nursing code of professional conduct is to guide nurses to make appropriate clinical decision, in particular when facing ethical dilemma. It is of paramount importance that nurse educators understand baccalaureate nursing students' perceptions of the importance of the code of professional conduct and the level of difficulties in implementing this code while preparing them for future practicing nurses. The Code of Professional Conduct in Hong Kong has been developed to guide nursing practice for over two decades. Nevertheless, no study has examined Hong Kong baccalaureate nursing students' perception about this professional code. The aim of this paper was to examine the perceptions of 263 baccalaureate nursing students about this professional code using a cross sectional survey design. The results indicated that most items in the professional code were rated as important and "provide safe and competent care" was rated as the most important one. A few areas that the students perceived as difficult to implement were discussed and future research was recommended. The significant differences identified among students from different years of study also highlighted areas for consideration in planning educational program to further equip students with the ability to deal with challenges in professional practice.

  11. Perceptions of professional attributes in medicine: a qualitative study in Hong Kong.

    Science.gov (United States)

    Leung, Danny C; Hsu, Enoch K; Hui, Edwin C

    2012-08-01

    OBJECTIVE. Medical professionalism has been widely discussed in western scholarly literature. However, since Hong Kong has a mixed Chinese-western culture, it remains uncertain whether Hong Kong health care professionals, medical students, and patients see medical professionalism in exactly the same way as westerners. The objective of the present study was to explore perceptions of medical professionalism in Hong Kong. DESIGN. Individual semi-structured interviews. SETTING. Medical faculty preceptors, residents, interns, nurses, and students from the Li Ka Shing Faculty of Medicine of the University of Hong Kong. Subjects were recruited at an out-patient clinic of Queen Mary Hospital. PARTICIPANTS. We interviewed 39 subjects, including six medical faculty preceptors, six hospital residents, four medical interns, eight nurses, eight out-patients, and seven medical students. The interviews were transcribed and coded. Grounded theory was employed for framing and analysing the interviews. RESULTS. A total of 30 primary themes were identified and grouped under three secondary themes, ie 'Expectations of a professional doctor', 'Work values', and 'Patient care'. In general, the primary themes were consistent with recognised professional attributes in western bioethics, such as knowledge and skills, holistic care, and communication skills. A closer analysis suggested that traditional Chinese thought also played an important role in shaping the medical professionalism of Hong Kong. Challenges to be faced by Hong Kong doctors due to recent social changes were also identified. CONCLUSIONS. Medical professionalism in Hong Kong is shaped by both western medical ethics and traditional Chinese thought. The values treasured by Hong Kong health care professionals as well as technological advance, and the city's proximity to Mainland China makes Hong Kong health care unique. It is important to maintain the present work attitudes and at the same time adapt to new social changes.

  12. Marked endotheliotropism of highly pathogenic avian influenza virus H5N1 following intestinal inoculation in cats

    NARCIS (Netherlands)

    L.A. Reperant (Leslie); M.W.G. van de Bildt (Marco); G. van Amerongen (Geert); L.M.E. Leijten (Lonneke); S. Watson (Sarah)

    2012-01-01

    textabstractHighly pathogenic avian influenza virus (HPAIV) H5N1 can infect mammals via the intestine; this is unusual since influenza viruses typically infect mammals via the respiratory tract. The dissemination of HPAIV H5N1 following intestinal entry and associated pathogenesis are largely unknow

  13. 75 FR 69046 - Notice of Determination of the High Pathogenic Avian Influenza Subtype H5N1 Status of Czech...

    Science.gov (United States)

    2010-11-10

    ... Pathogenic Avian Influenza Subtype H5N1 Status of Czech Republic and Sweden AGENCY: Animal and Plant Health... the highly pathogenic avian influenza (HPAI) subtype H5N1 status of the Czech Republic and Sweden... status of the Czech Republic and Sweden relative to highly pathogenic avian influenza (HPAI) subtype...

  14. Spatio-temporal magnitude and direction of highly pathogenic avian influenza (H5N1) outbreaks in Bangladesh

    DEFF Research Database (Denmark)

    Ahmed, Syed Sayeem Uddin; Ersbøll, Annette Kjær; Biswas, Paritosh K.;

    2011-01-01

    The number of outbreaks of HPAI-H5N1 reported by Bangladesh from 2007 through 2011 placed the country among the highest reported numbers worldwide. However, so far, the understanding of the epidemic progression, direction, intensity, persistence and risk variation of HPAI-H5N1 outbreaks over space...... and time in Bangladesh remains limited....

  15. Highly Pathogenic Avian Influenza H5N1 Clade 2.3.2.1c Virus in Lebanon, 2016.

    Science.gov (United States)

    El Romeh, Ali; Zecchin, Bianca; Fusaro, Alice; Ibrahim, Elias; El Bazzal, Bassel; El Hage, Jeanne; Milani, Adelaide; Zamperin, Gianpiero; Monne, Isabella

    2017-06-01

    We report the phylogenetic analysis of the first outbreak of H5N1 highly pathogenic avian influenza virus detected in Lebanon from poultry in April 2016. Our whole-genome sequencing analysis revealed that the Lebanese H5N1 virus belongs to genetic clade 2.3.2.1c and clusters with viruses from Europe and West Africa.

  16. Marked endotheliotropism of highly pathogenic avian influenza virus H5N1 following intestinal inoculation in cats

    NARCIS (Netherlands)

    Reperant, Leslie A; van de Bildt, Marco W G; van Amerongen, Geert; Leijten, Lonneke M E; Watson, Simon; Palser, Anne; Kellam, Paul; Eissens, Anko C; Frijlink, Hendrik W; Osterhaus, Albert D M E; Kuiken, Thijs; Frijlink, Henderik

    2012-01-01

    Highly pathogenic avian influenza virus (HPAIV) H5N1 can infect mammals via the intestine; this is unusual since influenza viruses typically infect mammals via the respiratory tract. The dissemination of HPAIV H5N1 following intestinal entry and associated pathogenesis are largely unknown. To assess

  17. Bronchointerstitial pneumonia in guinea pigs following inoculation with H5N1 high pathogenicity avian influenza virus

    Science.gov (United States)

    The H5N1 high pathogenicity avian influenza (HPAI) viruses have caused widespread disease of poultry in Asia, Africa and the Middle East, and sporadic human infections. The guinea pig model has been used to study human H3N2 and H1N1 influenza viruses, but knowledge is lacking on H5N1 HPAI virus inf...

  18. Cross-protection against lethal H5N1 challenge ferrets with an adjuvanted pandemic influenza vaccine

    NARCIS (Netherlands)

    B. Baras (Benoît); K.J. Stittelaar (Koert); J.H. Simon (James); R.J.M.M. Thoolen (Robert); S.P. Mossman (Sally); F.H. Pistoor (Frank); G. van Amerongen (Geert); M.A. Wettendorff (Martine); E. Hanon (Emmanuel); A.D.M.E. Osterhaus (Albert)

    2008-01-01

    textabstractBackground. Unprecedented spread between birds and mammals of highly pathogenic avian influenza viruses (HPAI) of the H5N1 subtype has resulted in hundreds of human infections with a high fatality rate. This has highlighted the urgent need for the development of H5N1 vaccines that can be

  19. Marked endotheliotropism of highly pathogenic avian influenza virus H5N1 following intestinal inoculation in cats

    NARCIS (Netherlands)

    L.A. Reperant (Leslie); M.W.G. van de Bildt (Marco); G. van Amerongen (Geert); L.M.E. Leijten (Lonneke); S. Watson (Sarah)

    2012-01-01

    textabstractHighly pathogenic avian influenza virus (HPAIV) H5N1 can infect mammals via the intestine; this is unusual since influenza viruses typically infect mammals via the respiratory tract. The dissemination of HPAIV H5N1 following intestinal entry and associated pathogenesis are largely

  20. Spatio-temporal magnitude and direction of highly pathogenic avian influenza (H5N1) outbreaks in Bangladesh

    DEFF Research Database (Denmark)

    Ahmed, Syed Sayeem Uddin; Ersbøll, Annette Kjær; Biswas, Paritosh K.

    2011-01-01

    The number of outbreaks of HPAI-H5N1 reported by Bangladesh from 2007 through 2011 placed the country among the highest reported numbers worldwide. However, so far, the understanding of the epidemic progression, direction, intensity, persistence and risk variation of HPAI-H5N1 outbreaks over spac...

  1. PM10 and CO Exposure of Hong Kong Population in Public Transit Facilities

    Institute of Scientific and Technical Information of China (English)

    TU Edward Y(涂有); CHAU C K(周志坤); CHAN Daniel W T(陈维田); BURNETT John; TU Guang-bei(涂光备)

    2003-01-01

    Taking public transit facilities (PTFs) is the major transport style in Hong Kong. Human exposure to indoor air pollutants may cause adverse health effects to the passengers. Exposure assessment on air pollutants is important for the control of human diseases caused by indoor air pollution. In this paper, the indoor PM10, CO and CO2 levels in various PTFs, such as public bus, subway, railway and ferry in Hong Kong, were mea-sured. Combining with the time budget survey of Hong Kong population,the human exposures were calculated through Monte-Carlo simulation.

  2. Factors Affecting the Understanding and Use of Psychoanalysis in Hong Kong, Mainland China, and Taiwan.

    Science.gov (United States)

    Busiol, Diego

    2015-06-01

    The majority of Western psychotherapies are known and practiced in Hong Kong, while psychoanalysis still has little resonance. A recent study finds that psychoanalysis is perceived neither as ineffective nor as necessarily in conflict with Hong Kong Chinese values. Nevertheless, Hong Kong Chinese culture influences how psychoanalysis is received and understood, when compared to Mainland China and Taiwan. It is argued that a better reception in the latter two was possible because of different social and historical backgrounds, different clinical backgrounds of those who receive training, and the more active role of Western psychoanalysts.

  3. Health Profile of Construction Workers in Hong Kong

    Directory of Open Access Journals (Sweden)

    Wen Yi

    2016-12-01

    Full Text Available Construction is a manual, heavy, and complex sector concerning the most fatal accidents and high incidence of occupational illnesses and injuries resulting in days away from work. In Hong Kong, “Pilot Medical Examination Scheme for Construction Workers” was launched in 2014 to detect the health problems of their construction workforce. All registered workers under the Construction Workers Registration Board are eligible to join the scheme. The purpose of this paper is to assess the physical condition, physiological status, and musculoskeletal disorders of 942 construction workers in Hong Kong. This study adopted a two-phase design, which includes a basic medical examination to measure the workers’ physiological parameters, such as blood pressure, resting heart rate, glucose, cholesterol, uric acid, liver function test, and renal function test; as well as a face-to-face interview following the medical examination to collect their demographic information and pain experience. Individual characteristics, including gender, age, obesity, alcohol drinking habit, and sleeping habit influenced the health condition of construction workers. Among the participants, 36.1% and 6.5% of them were overweight and obese, respectively. In addition, 43.0%, 38.4%, 16.2%, and 13.9% of the participants exceeded the thresholds of cholesterol, blood pressure, urea nitrogen, and uric urea, correspondingly. Moreover, 41.0% of the participants suffered musculoskeletal pain, where the most frequent painful parts occur in the lower back, shoulder, knees, leg, and neck. Through these findings, a series of important issues that need to be addressed is pointed out in terms of maintaining the physical well-being and reducing musculoskeletal disorders of construction workers. The finding may have implications for formulating proper intervention strategies for the sustainable development of Hong Kong’s construction industry.

  4. Heterosubtype neutralizing responses to influenza A (H5N1 viruses are mediated by antibodies to virus haemagglutinin.

    Directory of Open Access Journals (Sweden)

    Jean-Michel Garcia

    Full Text Available BACKGROUND: It is increasingly clear that influenza A infection induces cross-subtype neutralizing antibodies that may potentially confer protection against zoonotic infections. It is unclear whether this is mediated by antibodies to the neuraminidase (NA or haemagglutinin (HA. We use pseudoviral particles (H5pp coated with H5 haemagglutinin but not N1 neuraminidase to address this question. In this study, we investigate whether cross-neutralizing antibodies in persons unexposed to H5N1 is reactive to the H5 haemagglutinin. METHODOLOGY/PRINCIPAL FINDINGS: We measured H5-neutralization antibody titers pre- and post-vaccination using the H5N1 micro-neutralization test (MN and H5pp tests in subjects given seasonal vaccines and in selected sera from European elderly volunteers in a H5N1 vaccine trial who had detectable pre-vaccination H5N1 MN antibody titers. We found detectable (titer > or = 20 H5N1 neutralizing antibodies in a minority of pre-seasonal vaccine sera and evidence of a serological response to H5N1 in others after seasonal influenza vaccination. There was excellent correlation in the antibody titers between the H5N1 MN and H5pp tests. Similar correlations were found between MN and H5pp in the pre-vaccine sera from the cohort of H5N1 vaccine trial recipients. CONCLUSIONS/SIGNIFICANCE: Heterosubtype neutralizing antibody to H5N1 in healthy volunteers unexposed to H5N1 is mediated by cross-reaction to the H5 haemagglutinin.

  5. The special neuraminidase stalk-motif responsible for increased virulence and pathogenesis of H5N1 influenza A virus.

    Directory of Open Access Journals (Sweden)

    Hongbo Zhou

    Full Text Available The variation of highly pathogenic avian influenza H5N1 virus results in gradually increased virulence in poultry, and human cases continue to accumulate. The neuraminidase (NA stalk region of influenza virus varies considerably and may associate with its virulence. The NA stalk region of all N1 subtype influenza A viruses can be divided into six different stalk-motifs, H5N1/2004-like (NA-wt, WSN-like, H5N1/97-like, PR/8-like, H7N1/99-like and H5N1/96-like. The NA-wt is a special NA stalk-motif which was first observed in H5N1 influenza virus in 2000, with a 20-amino acid deletion in the 49(th to 68(th positions of the stalk region. Here we show that there is a gradual increase of the special NA stalk-motif in H5N1 isolates from 2000 to 2007, and notably, the special stalk-motif is observed in all 173 H5N1 human isolates from 2004 to 2007. The recombinant H5N1 virus with the special stalk-motif possesses the highest virulence and pathogenicity in chicken and mice, while the recombinant viruses with the other stalk-motifs display attenuated phenotype. This indicates that the special stalk-motif has contributed to the high virulence and pathogenicity of H5N1 isolates since 2000. The gradually increasing emergence of the special NA stalk-motif in H5N1 isolates, especially in human isolates, deserves attention by all.

  6. The Hong Kong Chinese University Document Retrieval Database——The Hong Kong Newspaper Full-text Database Projeet

    Institute of Scientific and Technical Information of China (English)

    MichaelM.Lee

    1994-01-01

    This project is to collect, organize, index and store full-text and graphics of selected Chinese and English newspapers currently published in Hang Kong. The end product will be an electronic database available to researchers through local area network, Internet and dial-up users. New items of the day before and up to six months will be available for online searching, via key word or subject, Earlier cumulated nateriats alone with the same indexing and searchmg software will be archived to optical media (CD ROM disks). As Itong Kong experiences rapid social, financial, conmtercial, political, educational and cultural changes, our state-of-the-art comprehensive coverage of local and regional newspapers will be a landmark contribution to information industries and researchers internationally. As the coverage of the database will be comprehensive and centralized, retrieval of news items of major Hang Kong newspapers will be fast and immtediate. Users do no need to look through daily or bi-monthly indexes in order to go to the newspapers or cuttings to obtain the hard copy, and then bring to the photocopier machine to copy,At this stage, we are hiring librarians, information specialists and support staff to work on this project. We also met and work with newspaper indexing and retrieval system developers in Beijing and Hang Kong to study cooperative systems to speed up the process. So far, we have received funding support from the Chinese University and the Hong Kong Government for two years. It is our plan to have a presentable sample database done by mid 1995, and have several newspapers indexed and stored in the structure arid for mat easy formigration to the eventual database system by the end of 1996.

  7. A recombinant vaccine of H5N1 HA1 fused with foldon and human IgG Fc induced complete cross-clade protection against divergent H5N1 viruses.

    Directory of Open Access Journals (Sweden)

    Lanying Du

    Full Text Available Development of effective vaccines to prevent influenza, particularly highly pathogenic avian influenza (HPAI caused by influenza A virus (IAV subtype H5N1, is a challenging goal. In this study, we designed and constructed two recombinant influenza vaccine candidates by fusing hemagglutinin 1 (HA1 fragment of A/Anhui/1/2005(H5N1 to either Fc of human IgG (HA1-Fc or foldon plus Fc (HA1-Fdc, and evaluated their immune responses and cross-protection against divergent strains of H5N1 virus. Results showed that these two recombinant vaccines induced strong immune responses in the vaccinated mice, which specifically reacted with HA1 proteins and an inactivated heterologous H5N1 virus. Both proteins were able to cross-neutralize infections by one homologous strain (clade 2.3 and four heterologous strains belonging to clades 0, 1, and 2.2 of H5N1 pseudoviruses as well as three heterologous strains (clades 0, 1, and 2.3.4 of H5N1 live virus. Importantly, immunization with these two vaccine candidates, especially HA1-Fdc, provided complete cross-clade protection against high-dose lethal challenge of different strains of H5N1 virus covering clade 0, 1, and 2.3.4 in the tested mouse model. This study suggests that the recombinant fusion proteins, particularly HA1-Fdc, could be developed into an efficacious universal H5N1 influenza vaccine, providing cross-protection against infections by divergent strains of highly pathogenic H5N1 virus.

  8. Avian Influenza (H5N1) Warning System using Dempster-Shafer Theory and Web Mapping

    CERN Document Server

    Maseleno, Andino

    2012-01-01

    Based on Cumulative Number of Confirmed Human Cases of Avian Influenza (H5N1) Reported to World Health Organization (WHO) in the 2011 from 15 countries, Indonesia has the largest number death because Avian Influenza which 146 deaths. In this research, the researcher built a Web Mapping and Dempster-Shafer theory as early warning system of avian influenza. Early warning is the provision of timely and effective information, through identified institutions, that allows individuals exposed to a hazard to take action to avoid or reduce their risk and prepare for effective response. In this paper as example we use five symptoms as major symptoms which include depression, combs, wattle, bluish face region, swollen face region, narrowness of eyes, and balance disorders. Research location is in the Lampung Province, South Sumatera. The researcher reason to choose Lampung Province in South Sumatera on the basis that has a high poultry population. Geographically, Lampung province is located at 103040' to 105050' East Lo...

  9. Role of Positive Selection Pressure on the Evolution of H5N1 Hemagglutinin

    Institute of Scientific and Technical Information of China (English)

    Venkata R.S.K. Duwuri; Bhargavi Duvvuri; Wilfred R. Cuff; Gillian E. Wu; Jianhong Wu

    2009-01-01

    The surface glycoprotein hemagglutinin (HA) helps the influenza A virus to evade the host immune system by antigenic variation and is a major driving force for viral evolution. In this study, the selection pressure on HA of H5N1 influenza A virus was analyzed using bioinformatics algorithms. Most of the identified positive selection (PS) sites were found to be within or adjacent to epitope sites. Some of the identified PS sites are consistent with previous experimental studies, providing further support to the biological significance of our findings. The highest frequency of PS sites was observed in recent strains isolated during 2005-2007. Phylogenetic analysis was also conducted on HA sequences from various hosts. Viral drift is almost similar in both avian and human species with a progressive trend over the years. Our study reports new mutations in functional regions of HA that might provide markers for vaccine design or can be used to predict isolates of pandemic potential.

  10. Spatial distribution and risk factors of highly pathogenic avian influenza (HPAI) H5N1 in China

    Science.gov (United States)

    Martin, Vincent; Pfeiffer, Dirk U.; Zhou, Xiaoyan; Xiao, Xiangming; Prosser, Diann J.; Guo, Fusheng; Gilbert, Marius

    2011-01-01

    Highly pathogenic avian influenza (HPAI) H5N1 was first encountered in 1996 in Guangdong province (China) and started spreading throughout Asia and the western Palearctic in 2004–2006. Compared to several other countries where the HPAI H5N1 distribution has been studied in some detail, little is known about the environmental correlates of the HPAI H5N1 distribution in China. HPAI H5N1 clinical disease outbreaks, and HPAI virus (HPAIV) H5N1 isolated from active risk-based surveillance sampling of domestic poultry (referred to as HPAIV H5N1 surveillance positives in this manuscript) were modeled separately using seven risk variables: chicken, domestic waterfowl population density, proportion of land covered by rice or surface water, cropping intensity, elevation, and human population density. We used bootstrapped logistic regression and boosted regression trees (BRT) with cross-validation to identify the weight of each variable, to assess the predictive power of the models, and to map the distribution of HPAI H5N1 risk. HPAI H5N1 clinical disease outbreak occurrence in domestic poultry was mainly associated with chicken density, human population density, and elevation. In contrast, HPAIV H5N1 infection identified by risk-based surveillance was associated with domestic waterfowl density, human population density, and the proportion of land covered by surface water. Both models had a high explanatory power (mean AUC ranging from 0.864 to 0.967). The map of HPAIV H5N1 risk distribution based on active surveillance data emphasized areas south of the Yangtze River, while the distribution of reported outbreak risk extended further North, where the density of poultry and humans is higher. We quantified the statistical association between HPAI H5N1 outbreak, HPAIV distribution and post-vaccination levels of seropositivity (percentage of effective post-vaccination seroconversion in vaccinated birds) and found that provinces with either outbreaks or HPAIV H5N1 surveillance

  11. Influenza H5N1 virus infection of polarized human alveolar epithelial cells and lung microvascular endothelial cells

    Directory of Open Access Journals (Sweden)

    Yuen Kit M

    2009-10-01

    Full Text Available Abstract Background Highly pathogenic avian influenza (HPAI H5N1 virus is entrenched in poultry in Asia and Africa and continues to infect humans zoonotically causing acute respiratory disease syndrome and death. There is evidence that the virus may sometimes spread beyond respiratory tract to cause disseminated infection. The primary target cell for HPAI H5N1 virus in human lung is the alveolar epithelial cell. Alveolar epithelium and its adjacent lung microvascular endothelium form host barriers to the initiation of infection and dissemination of influenza H5N1 infection in humans. These are polarized cells and the polarity of influenza virus entry and egress as well as the secretion of cytokines and chemokines from the virus infected cells are likely to be central to the pathogenesis of human H5N1 disease. Aim To study influenza A (H5N1 virus replication and host innate immune responses in polarized primary human alveolar epithelial cells and lung microvascular endothelial cells and its relevance to the pathogenesis of human H5N1 disease. Methods We use an in vitro model of polarized primary human alveolar epithelial cells and lung microvascular endothelial cells grown in transwell culture inserts to compare infection with influenza A subtype H1N1 and H5N1 viruses via the apical or basolateral surfaces. Results We demonstrate that both influenza H1N1 and H5N1 viruses efficiently infect alveolar epithelial cells from both apical and basolateral surface of the epithelium but release of newly formed virus is mainly from the apical side of the epithelium. In contrast, influenza H5N1 virus, but not H1N1 virus, efficiently infected polarized microvascular endothelial cells from both apical and basolateral aspects. This provides a mechanistic explanation for how H5N1 virus may infect the lung from systemic circulation. Epidemiological evidence has implicated ingestion of virus-contaminated foods as the source of infection in some instances and our

  12. H5N1禽流感文献计量与可视化分析%Metrology and visualized analysis of H5N1 virus:a research of literature

    Institute of Scientific and Technical Information of China (English)

    陈婷; 吴曙霞; 盛立; 刘伟; 刁天喜

    2015-01-01

    目的:对国内外H5N1禽流感研究文献进行文献计量及可视化知识图谱分析。方法基于Web of Knowledge文献数据平台(SCI),综合应用Bibexcel、VOSviewer和Pajek等软件,展示全球H5N1禽流感研究的主要领域和前沿。结果从文献分析结果来看,全球H5 N1禽流感研究从2005年开始持续多年处于高水平态势,美国在这一领域处于领先地位,中国紧随其后。结论 H5 N1禽流感文献计量可视化分析显示,全球多国科学家常年都十分重视H5 N1禽流感研究,美国H5 N1禽流感研究整体实力最强,我国与国际相关研究机构还有一定差距,因此,应加强H5 N1禽流感研究,提高我国H5 N1禽流感研究整体实力水平,为应对可能发生的公共卫生突发事件提供必要的保障。%Objective To analyze domestic and foreign papers on H5N1 virus research using literature metrology and visualized knowledge mapping.Methods Pajek, Bibexcel,and VoSviewer software were used based on Web of Knowledge platform.Results Study on H5N1 virus has been a research focus wide since 2005 and a series of institutions and investi-gators have appeared, with US being the leader in this area and followed by China.The most popular topics of studies on H5N1 included its virology, epidemiology, basic research, anti-virus drugs and vaccines.Conclusion Studies on H5N1 have received more attention, which suggests that more efforts have to be made in China in terms of communication and co-operation with key institutions and famous researchers so as to achieve more success in key areas.

  13. Vaccine Design for H5N1 Based on B- and T-cell Epitope Predictions.

    Science.gov (United States)

    Tambunan, Usman Sumo Friend; Sipahutar, Feimmy Ruth Pratiwi; Parikesit, Arli Aditya; Kerami, Djati

    2016-01-01

    From 2003 to 2013, Indonesia had the highest number of avian influenza A cases in humans, with 192 cases and 160 fatalities. Avian influenza is caused by influenza virus type A, such as subtype H5N1. This virus has two glycoproteins: hemagglutinin and neuraminidase, which will become the primary target to be neutralized by vaccine. Vaccine is the most effective immunologic intervention. In this study, we use the epitope-based vaccine design from hemagglutinin and neuraminidase of H5N1 Indonesian strain virus by using immunoinformatics approach in order to predict the binding of B-cell and T-cell epitopes (class I and class II human leukocyte antigen [HLA]). BCPREDS was used to predict the B-cell epitope. Propred, Propred I, netMHCpan, and netMHCIIpan were used to predict the T-cell epitope. Two B-cell epitopes of hemagglutinin candidates and one B-cell epitope of neuraminidase candidates were obtained to bind T-cell CD4(+) (class II HLA), and also five T-cell epitope hemagglutinin and four T-cell epitope neuraminidase were obtained to bind T-cell CD8(+) (class I HLA). The visualization of epitopes was done using MOE 2008.10. It shows that the binding affinity of epitope-HLA was based on minimum binding free energy (ΔG binding). Based on this result, visualization, and dynamic simulation, four hemagglutinin epitopes (MEKIVLLLA, CPYLGSPSF, KCQTPMGAI, and IGTSTLNQR) and two neuraminidase epitopes (NPNQKIITI and CYPDAGEIT) were computed as having the best binding affinity from HLA ligand. The results mentioned above are from in silico experiments and need to be validated using wet experiment.

  14. Smartphone-Based Fluorescent Diagnostic System for Highly Pathogenic H5N1 Viruses.

    Science.gov (United States)

    Yeo, Seon-Ju; Choi, Kyunghan; Cuc, Bui Thi; Hong, Nguyen Ngoc; Bao, Duong Tuan; Ngoc, Nguyen Minh; Le, Mai Quynh; Hang, Nguyen Le Khanh; Thach, Nguyen Co; Mallik, Shyam Kumar; Kim, Hak Sung; Chong, Chom-Kyu; Choi, Hak Soo; Sung, Haan Woo; Yu, Kyoungsik; Park, Hyun

    2016-01-01

    Field diagnostic tools for avian influenza (AI) are indispensable for the prevention and controlled management of highly pathogenic AI-related diseases. More accurate, faster and networked on-site monitoring is demanded to detect such AI viruses with high sensitivity as well as to maintain up-to-date information about their geographical transmission. In this work, we assessed the clinical and field-level performance of a smartphone-based fluorescent diagnostic device with an efficient reflective light collection module using a coumarin-derived dendrimer-based fluorescent lateral flow immunoassay. By application of an optimized bioconjugate, a smartphone-based diagnostic device had a two-fold higher detectability as compared to that of the table-top fluorescence strip reader for three different AI subtypes (H5N3, H7N1, and H9N2). Additionally, in a clinical study of H5N1-confirmed patients, the smartphone-based diagnostic device showed a sensitivity of 96.55% (28/29) [95% confidence interval (CI): 82.24 to 99.91] and a specificity of 98.55% (68/69) (95% CI: 92.19 to 99.96). The measurement results from the distributed individual smartphones were wirelessly transmitted via short messaging service and collected by a centralized database system for further information processing and data mining. Smartphone-based diagnosis provided highly sensitive measurement results for H5N1 detection within 15 minutes. Because of its high sensitivity, portability and automatic reporting feature, the proposed device will enable agile identification of patients and efficient control of AI dissemination.

  15. Induction of long-term protective immune responses by influenza H5N1 virus-like particles.

    Directory of Open Access Journals (Sweden)

    Sang-Moo Kang

    Full Text Available BACKGROUND: Recurrent outbreaks of highly pathogenic H5N1 avian influenza virus pose a threat of eventually causing a pandemic. Early vaccination of the population would be the single most effective measure for the control of an emerging influenza pandemic. METHODOLOGY/PRINCIPAL FINDINGS: Influenza virus-like particles (VLPs produced in insect cell-culture substrates do not depend on the availability of fertile eggs for vaccine manufacturing. We produced VLPs containing influenza A/Viet Nam1203/04 (H5N1 hemagglutinin, neuraminidase, and matrix proteins, and investigated their preclinical immunogenicity and protective efficacy. Mice immunized intranasally with H5N1 VLPs developed high levels of H5N1 specific antibodies and were 100% protected against a high dose of homologous H5N1 virus infection at 30 weeks after immunization. Protection is likely to be correlated with humoral and cellular immunologic memory at systemic and mucosal sites as evidenced by rapid anamnestic responses to re-stimulation with viral antigen in vivo and in vitro. CONCLUSIONS/SIGNIFICANCE: These results provide support for clinical evaluation of H5N1 VLP vaccination as a public health intervention to mitigate a possible pandemic of H5N1 influenza.

  16. Sequence and epitope analysis of surface proteins of avian influenza H5N1 viruses from Asian patients

    Institute of Scientific and Technical Information of China (English)

    LI Guanglin; TAO Shiheng; WANG Xiujie

    2006-01-01

    Increasing cases of human infections with the high pathogenic avian influenza virus H5N1 have raised great concern on potential human flu pandemics caused by H5N1. The two viral surface glycoproteins, the hemagglutinin (HA) and the neuraminidase (NA) proteins, are major antigens of H5N1. Introducing new mutations on these two proteins is the major strategy used by H5N1 to expand host range and to avoid the recognition of host immune systems. We analyzed the two surface proteins of H5N1 from Asian human patients and identified many new mutation sites, including a few that were unique to certain lethal strains. We also analyzed the distribution of mutations on different epitopes of the two surface proteins. A receptor-binding site that might involve in the determination of host specificity of H5N1 was also found. Results reported here provided information for better understanding of the evolution trend of H5N1 genome in human.

  17. Seroprevalence of avian influenza A (H5N1 virus among poultry workers in Jiangsu Province, China: an observational study

    Directory of Open Access Journals (Sweden)

    Huo Xiang

    2012-04-01

    Full Text Available Abstract Background Since 2003 to 06 Jan 2012, the number of laboratory confirmed human cases of infection with avian influenza in China was 41 and 27 were fatal. However, the official estimate of the H5N1 case-fatality rate has been described by some as an over estimation since there may be numerous undetected asymptomatic/mild cases of H5N1 infection. This study was conducted to better understand the real infection rate and evaluate the potential risk factors for the zoonotic spread of H5N1 viruses to humans. Methods A seroepidemiological survey was conducted in poultry workers, a group expected to have the highest level of exposure to H5N1-infected birds, from 3 counties with habitat lakes of wildfowl in Jiangsu province, China. Serum specimens were collected from 306 participants for H5N1 serological test. All participants were interviewed to collect information about poultry exposures. Results The overall seropositive rate was 2.61% for H5N1 antibodies. The poultry number was found associated with a 2.39-fold significantly increased subclinical infection risk after adjusted with age and gender. Conclusions Avian-to -human transmission of avian H5N1 virus remained low. Workers associated with raising larger poultry flocks have a higher risk on seroconversion.

  18. Influenza A virus H5N1 entry into host cells is through clathrin-dependent endocytosis

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    Influenza A virus H5N1 presents a major threat to human health. The entry of influenza virus into host cells is believed to be mediated by hemagglutinin (HA), a virus surface glycoprotein that can bind terminal sialic acid residues on host cell glycoproteins and glycolipids. In this study, we elucidated the pathways through which H5N1 enters human lung carcinoma cell line A549. We first proved that H5N1 can enter A549 cells via endocytosis, as lysosomotropic agents, such as bafilomycin A1 and chloroquine, can rescue H5N1-induced A549 cell death. By using specific inhibitors, and siRNAs that target the clathrin pathway, we further found that H5N1 could enter A549 cells via clathrin-mediated endocytosis, while inhibitors targeting caveolae-mediated endocytosis could not inhibit H5N1 cell entry. These findings expand our understanding of H5N1 pathogenesis and provide new information for anti-viral drug research.

  19. A survey on misunderstanding of dental scaling in Hong Kong.

    Science.gov (United States)

    Young, Cecilia

    2008-02-01

    There is no information on the misunderstanding of dental scaling; on whether the misunderstanding affects the general public to go for scaling or not; on complaints about dental scaling and suggestion of who should educate the public in the existing literature. This study gives the information from the general public in Hong Kong. A cross-sectional survey by telephone interview on a random sample of 1412 subjects aged 13 years and above in Hong Kong was conducted from 3rd January to 15th February 2006. More females had received scaling (adjusted OR = 1.73, 95%CI 1.31-2.29 P < 0.001), 51-60 years age group had the highest scaling experience (adjusted OR = 2.69, 95% CI 1.55-4.68, P < 0.001). Higher education was related to scaling experience (P < 0.001). Of the subjects with complete data, 22.5% (307/1364) had never received dental scaling, 17.9% (55/307) did not understand the purpose, 12.1% (37/307) replied that it would make the teeth thinner, 11.4% (35/307) replied that the gum space would become wider, and 11.4% (35/307) stated that scaling would damage the gum. In all, 45.9% (298/649) of the subject reported bleeding, 33.7% (139/413) sensitivity, 40.5% (62/153) smaller teeth and 23.9% (84/351) widened gum space because of mistakes made during the procedure; 8.6% (56/649) of those who experienced bleeding, 17.8% (27/152) of those who reported the teeth became smaller and 12% (42/350) of those who stated that the gum space became wider intended to reduce the frequency, delay or not go for scaling. A total of 79.6% (841/1057) experienced one of the perceived problems; 27.8% (234/841) had complained about scaling. This study shows a common lack of knowledge of dental scaling in the Hong Kong population. Patients should be better informed about the aim before the procedure.

  20. Late Immersion in Hong Kong: A Pedagogical Framework for Integrating Content-Language Teaching and Learning

    National Research Council Canada - National Science Library

    Stella Kong

    2008-01-01

    Despite a long history of publicly-funded English immersion education, late immersion in Hong Kong is not achieving the dual goals of content and second language learning at levels that an immersion...

  1. Under Construction: The Development of Multicultural Curriculum in Hong Kong and Taiwan

    National Research Council Canada - National Science Library

    Jackson, Liz

    2014-01-01

    ...culturalism in curriculum content. At the same time, Hong Kong and Taiwan both face tensions today related to competing priorities for cultivating local, national, and global senses of identity and civic participation...

  2. The Rise of Civic Nationalism: Shifting Identities in Hong Kong and Taiwan

    Directory of Open Access Journals (Sweden)

    Justin P. Kwan

    2016-08-01

    Full Text Available The rise of civic nationalism in both Hong Kong and Taiwan indicates a prominence of democratic liberal values which are contributing to the further rejection of an ethnonational Chinese identity imposed by Beijing. Using the 2014 Umbrella Movement in Hong Kong and the Sunflower Movement in Taiwan as case studies, this paper examines how the rise of civic nationalism is furthering the nation-building project of Hong Kong and Taiwanese identities. Following a comparison between the Umbrella Movement and the Sunflower Movement in terms of the sequence of events, the paper identifies the impact of the movements on both societies through an examination of the successes and failures of each movement, the rise of new political forces and party politics, as well as political institutions. The paper concludes by discussing the implications of the widening identity gap of Hong Kong and Taiwan from China.

  3. Development of a credit-bearing service leadership subject for university students in Hong Kong.

    Science.gov (United States)

    Shek, Daniel T L; Yu, Lu; Ma, Cecilia M S; Sun, Rachel C F; Liu, Ting Ting

    2013-01-01

    Given that service industries contribute to 93% of Hong Kong's GDP, an important question that should be asked is whether the education system can promote the development of service leadership among young people in Hong Kong. Unfortunately, service leadership programs specifically designed for university students are lacking in Hong Kong. In this paper, the basic tenets of the Service Leadership and Management framework are presented. Based on the fundamental postulation that effective service leadership is a function of moral character, competence and care (E=MC(2)), a subject called "Service Leadership" has recently been developed at The Hong Kong Polytechnic University. This paper outlines the objectives, intended learning outcomes, syllabus, assessment, and references of the subject. The proposed evaluation strategies are also described.

  4. TYPICAL WEATHER CHARACTERISTICS ASSOCIATED WITH AIR POLLUTION IN HONG KONG AREA

    Institute of Scientific and Technical Information of China (English)

    CHEN Xun-lai; FAN Shao-jia; LI Jiang-nan; LIU Ji; WANG An-yu; FONG Soi-kun

    2008-01-01

    With the hourly data of Air Pollution Index (API) by Hong Kong Environmental Protection Department (HKEPD) during the 6 years of 2000 - 2005 and NCEP / NCAR reanalysis data of 2.5°×2.5° wind and pressure fields, the characteristics of API in Hong Kong area and the impacts of typical weather characteristics on the air pollution in Hong Kong have been studied. The results are shown as follows. (1) The API exhibits obvious seasonal variability as the number of air pollution days increases by the year. For most of the local monitoring stations, it is the most from January to March, a little less from July to September and the least from April to June. (2) There are four typical types of weather situations that are responsible for the air pollution in Hong Kong: tropical cyclones, continental cold highs, transformed highs that have moved out to sea and low pressure troughs.

  5. Comparision of Istanbul with Hong Kong and Singapore for Regional Treasury Centers

    Directory of Open Access Journals (Sweden)

    Ahmet Selçuk DİZKIRICI

    2012-12-01

    Full Text Available The purpose of the study is examining Istanbul to find out whether or not it has the ability to become an appropriate location to host regional treasury centers. Hence; Simkova’s 11 location criteria are compared across Istanbul additionally Hong Kong and Singapore, being already attractive locations in South East Asia for multinational corporations to set up their regional finance offices, to specify Istanbul’s weaker facilities even if it is not regarded as a rival for Hong Kong and Singapore. The study contributes to the understanding of Simkova’s location criteria assessment before establishing a regional treasury center in any location, as it is applied to some European countries and three Asian countries: Brunei, Hong Kong and Singapore, previously. Lastly, it is concluded that Istanbul is not as superior as Hong Kong and Singapore but it has reasonable conditions to become an attractive location for regional treasury centers.

  6. A new species of Lophiotrema from wild fruit in Hong Kong

    NARCIS (Netherlands)

    Tang, A.M.C.; Hyde, K.D.; Tsui, K.M.; Corlett, R.T.

    2003-01-01

    Lophiotremapsychotrii spec. nov. is described and illustrated based on specimens occurring on Psychotria asiatica and Rhodomyrtus tomentosa fruits in Hong Kong. This species is characterized by small, hyaline, guttulate, uniseptate, fusiform ascospores bearing a narrow mucilaginous sheath, which is

  7. Safety and immunogenicity of Sinovac’s prototype pandemic influenza H5N1 vaccines: a review on clinical trials

    OpenAIRE

    Qiu, Yuan‐Zheng; Yin, Wei‐Dong

    2008-01-01

    Abstract  Sinovac Biotech started to develop prototype pandemic influenza H5N1 vaccines in March 2004. On 2 April 2008, Sinovac’s inactivated, aluminium‐adjuvanted, whole‐virion prototype pandemic influenza A (H5N1) vaccine (PanFlu™) was granted production licensure by the China regulatory authority State Food and Drug Administration. The whole‐virion H5N1 vaccine was manufactured in embryonated hens’ eggs using the reassortant strain NIBRG‐14 (A/Vietnam/1194/2004‐A/PR/8/34) as vaccine virus....

  8. Protective measures and H5N1-seroprevalence among personnel tasked with bird collection during an outbreak of avian influenza A/H5N1 in wild birds, Ruegen, Germany, 2006

    OpenAIRE

    Littmann Martina; Buda Silke; Buchholz Udo; Schweiger Brunhilde; Cai Wei; Heusler Jörg; Haas Walter

    2009-01-01

    Background: In Germany, the first outbreak of highly pathogenic avian influenza A/H5N1 occurred among wild birds on the island of Ruegen between February and April 2006. The aim of this study was to investigate the use of recommended protective measures and to measure H5N1- seroprevalence among personnel tasked with bird collection. Methods: Inclusion criteria of our study were participation in collecting wild birds on Ruegen between February and March 2006. Study participants w...

  9. A study on the development potential of bus rapid transit and modern tramways in Hong Kong

    OpenAIRE

    Ho, Choi-yan; 何采殷

    2015-01-01

    The cornerstone of the public transport policy of Hong Kong has been to position railway as the backbone of the transport network. With the adoption of an integrated approach of land-use planning and railway planning, there has been a remarkable achievement that railway now accounts for 41% of all trips made on public transport. Upon completion of the four railway projects by 2020, it will cover 70% of residential population of Hong Kong. Further on, there are anticipated challenges assoc...

  10. Recovery of Tourism Demand in Hong Kong from the Global Financial and Economic Crisis

    OpenAIRE

    K. Chon; Li, G; Lin, S.; Gao, Z.

    2010-01-01

    This study aims to predict the recovery of the Hong Kong tourism industry from the current global financial and economic crisis. Based on the latest statistics available, this study provides updated forecasts of tourist arrivals to Hong Kong from 10 key source markets over the period 2010-2015. The forecasts include annual and quarterly forecasts of tourist arrivals and the market shares of the source markets concerned. An econometric method is used to estimate the demand elasticities as well...

  11. Identifying Core Competencies of Infection Control Nurse Specialists in Hong Kong.

    Science.gov (United States)

    Chan, Wai Fong; Bond, Trevor G; Adamson, Bob; Chow, Meyrick

    2016-01-01

    To confirm a core competency scale for Hong Kong infection control nurses at the advanced nursing practice level from the core competency items proposed in a previous phase of this study. This would serve as the foundation of competency assurance in Hong Kong hospitals. A cross-sectional survey design was used. All public and private hospitals in Hong Kong. All infection control nurses in hospitals of Hong Kong. The 83-item proposed core competency list established in an earlier study was transformed into a questionnaire and sent to 112 infection control nurses in 48 hospitals in Hong Kong. They were asked to rate the importance of each infection prevention and control item using Likert-style response categories. Data were analyzed using the Rasch model. The response rate of 81.25% was achieved. Seven items were removed from the proposed core competency list, leaving a scale of 76 items that fit the measurement requirements of the unidimensional Rasch model. Essential core competency items of advanced practice for infection control nurses in Hong Kong were identified based on the measurement criteria of the Rasch model. Several items of the scale that reflect local Hong Kong contextual characteristics are distinguished from the overseas standards. This local-specific competency list could serve as the foundation for education and for certification of infection control nurse specialists in Hong Kong. Rasch measurement is an appropriate analytical tool for identifying core competencies of advanced practice nurses in other specialties and in other locations in a manner that incorporates practitioner judgment and expertise.

  12. Estimating Incidence of Developmental Dyslexia in Hong Kong: What Differences Do Different Criteria Make?

    Science.gov (United States)

    Chan, David W.; Ho, Connie Suk-han; Tsang, Suk-man; Lee, Suk-han; Chung, Kevin K. H.

    2008-01-01

    Based on the data of a school-referred sample of Cantonese-speaking Chinese children who met the Hong Kong criterion of dyslexia, we estimated for developmental dyslexia of Chinese children aged between 6 and 10 1/2 in Hong Kong an incidence rate of 0.66% and a gender ratio of 3.29 boys to 1 girl over a four-year period. We also explored the…

  13. A history of fishing with explosives and poisons in Hong Kong waters

    OpenAIRE

    Cornish, A.S.; McKellar, D.

    1998-01-01

    Fishing with explosives is still being practiced aroung Hong Kong. The first legislation against blast fishing was passed in Hong Kong in 1903. Since then, successive legislation has increased the penalties and fines on blast fishing and fishing with poisons. However, the problem has not been eliminated as enforcement puts pressure on the resources of the marine police. It would be more effective to educate the local communities on the destructive effects of these practices and make them more...

  14. What is the True Loss Due to Piracy?: Evidence from Microsoft Office in Hong Kong

    OpenAIRE

    Leung, Tin Cheuk

    2011-01-01

    Software piracy remains rampant despite the successful measures the Hong Kong government has taken to eradicate street piracy. This is because most people prefer substituting a counterfeit copy of a software CD (street piracy) with an illegal download of the software (Internet piracy). To support this claim, I construct a unique data set from 281 college students in Hong Kong to demonstrate two things. First, I estimate a random-coefficient discrete choice demand system for Microsoft Office f...

  15. Protection against H5N1 highly pathogenic avian and pandemic (H1N1) 2009 influenza virus infection in cynomolgus monkeys by an inactivated H5N1 whole particle vaccine.

    Science.gov (United States)

    Nakayama, Misako; Shichinohe, Shintaro; Itoh, Yasushi; Ishigaki, Hirohito; Kitano, Mitsutaka; Arikata, Masahiko; Pham, Van Loi; Ishida, Hideaki; Kitagawa, Naoko; Okamatsu, Masatoshi; Sakoda, Yoshihiro; Ichikawa, Takaya; Tsuchiya, Hideaki; Nakamura, Shinichiro; Le, Quynh Mai; Ito, Mutsumi; Kawaoka, Yoshihiro; Kida, Hiroshi; Ogasawara, Kazumasa

    2013-01-01

    H5N1 highly pathogenic avian influenza virus (HPAIV) infection has been reported in poultry and humans with expanding clade designations. Therefore, a vaccine that induces immunity against a broad spectrum of H5N1 viruses is preferable for pandemic preparedness. We established a second H5N1 vaccine candidate, A/duck/Hokkaido/Vac-3/2007 (Vac-3), in our virus library and examined the efficacy of inactivated whole particles of this strain against two clades of H5N1 HPAIV strains that caused severe morbidity in cynomolgus macaques. Virus propagation in vaccinated macaques infected with either of the H5N1 HPAIV strains was prevented compared with that in unvaccinated macaques. This vaccine also prevented propagation of a pandemic (H1N1) 2009 virus in macaques. In the vaccinated macaques, neutralization activity, which was mainly shown by anti-hemagglutinin antibody, against H5N1 HPAIVs in plasma was detected, but that against H1N1 virus was not detected. However, neuraminidase inhibition activity in plasma and T-lymphocyte responses in lymph nodes against H1N1 virus were detected. Therefore, cross-clade and heterosubtypic protective immunity in macaques consisted of humoral and cellular immunity induced by vaccination with Vac-3.

  16. Online Independent Vocabulary Learning Experience of Hong Kong University Students

    Directory of Open Access Journals (Sweden)

    Eunice Tang

    2016-03-01

    Full Text Available In response to the limited vocabulary size of its undergraduates, an independent vocabulary learning platform, VLearn was designed and launched in a university in Hong Kong. As an elearning environment that supports self-directed vocabulary learning of Chinese learners, the primary aim of VLearn is to equip users with appropriate knowledge and skills for vocabulary expansion. This paper introduces the contents of VLearn, and the theoretical underpinnings of its design. It also reports on the vocabulary learning experience of its users during an eight week evaluation study. Suggestions are made on how independent vocabulary building at higher education, as well as comprehensive vocabulary instruction at early years could be supported by means of technology.

  17. Parentage testing anomalies in Hong Kong SAR of China

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    Objective To determine if there are any differences in the number of exclusions from paternity of men using an anonymous parentage testing service compared with that of men using an in-person parentage testing service provided by the same company in Hong Kong SAR of China. Methods Comparable numbers of consecutive anonymous and in-person parentage tests conducted by the same company were analyzed. Results Men using an anonymous parentage testing service were excluded from paternity at a significantly greater rate (P<0.001), compared with men using an in-person parentage test service. Conclusions The results obtained from anonymous parentage testing indicate that the number of families containing children of doubtful parentage is much greater than expected previously. As illegitimate children are known to suffer greater degrees of abuse and neglect, this finding poses serious social questions regarding the welfare of families, which the relevant authorities should acknowledge and address.

  18. The air pollution index system in Hong Kong

    Energy Technology Data Exchange (ETDEWEB)

    Lee, F.Y.P.; Gervat, G.P. [Hong Kong Government, Wanchai (Hong Kong). Environmental Protection Dept.

    1995-12-31

    The Hong Kong Environmental Protection Department (EPD) is currently operating an air quality monitoring network in the territory. There are nine monitoring stations, each with air quality monitoring equipment, meteorological instruments and a data logger. Five minute averaged data are transmitted through telephone lines to the central computer at the EPD Air Laboratory and are also stored in the data logger on site, as backup. At present, the EPD releases its air quality measurements to the public via monthly and special press releases, and annual reports. However, as public awareness of air pollution problems has increased, there has been an urgent need for timely and simpler information about air pollution levels. The development and operation of an Air Pollution Index (API) system has addressed that need. This presentation discusses the API computation, the information and advice released to the general public and how they can access the API information. Some API results are also presented. (author)

  19. Capital Budgeting Evaluation Practices of Building Contractors in Hong Kong

    Directory of Open Access Journals (Sweden)

    K.C Lam

    2012-11-01

    Full Text Available This paper reports the results of an investigation into capital budgeting evaluation practicesin the construction industry of Hong Kong. The aim of this study was to identify thepopularity and extent of usage of various techniques for capital budget evaluation, investmentappraisal, risk analysis, and management science. The current study was comparedwith a similar survey conducted in 1994 to establish the changes in the capital budgetingevaluation practices of contracting firms over time. The results indicate that there was ageneral increase in the popularity and extent of usage in certain capital budget evaluationtechniques such as “best/worst estimate” and “formal financial evaluation”. In addition,the evaluation techniques examined were fitted into a discriminant function analysis (DFA,and a model has been developed which allows contracting firms to be classified accordingto their predominant characteristics in capital budget evaluation.

  20. Adolescent compensated dating in Hong Kong: choice, script, and dynamics.

    Science.gov (United States)

    Li, Jessica C M

    2015-06-01

    Although numerous studies have examined the prevalence, contributing factors, and consequences of compensated dating (CD) among young people, few empirical studies have investigated the process of engaging in CD. This article intends to fill this research gap through semi-structured interviews with 30 young people who have experience in CD in Hong Kong. The current study provides a step-by-step account of the involvement of young people in this illegal/immoral activity from a crime script perspective. Twelve decision-making points in four crime commission stages are identified in this study. The findings of the study will not only advance conceptual understanding of the choice, script, and dynamics of young people's path to CD but also provide suggestions for formulating stage-specific measures for situational crime prevention. This empirical study is the first to investigate the process of this specific emerging offense in the Chinese community.

  1. Access to primary care in Hong Kong, Greater London and New York City.

    Science.gov (United States)

    Chau, Pui Hing; Woo, Jean; Gusmano, Michael K; Weisz, Daniel; Rodwin, Victor G; Chan, Kam Che

    2013-01-01

    We investigate avoidable hospital conditions (AHC) in three world cities as a way to assess access to primary care. Residents of Hong Kong are healthier than their counterparts in Greater London or New York City. In contrast to their counterparts in New York City, residents of both Greater London and Hong Kong face no financial barriers to an extensive public hospital system. We compare residence-based hospital discharge rates for AHC, by age cohorts, in these cities and find that New York City has higher rates than Hong Kong and Greater London. Hong Kong has the lowest hospital discharge rates for AHC among the population 15-64, but its rates are nearly as high as those in New York City among the population 65 and over. Our findings suggest that in contrast to Greater London, older residents in Hong Kong and New York face significant barriers in accessing primary care. In all three cities, people living in lower socioeconomic status neighborhoods are more likely to be hospitalized for an AHC, but neighborhood inequalities are greater in Hong Kong and New York than in Greater London.

  2. Incidence of genital warts among the Hong Kong general adult population

    Science.gov (United States)

    2010-01-01

    Background The objective of this study is to estimate the incidence of genital warts in Hong Kong and explore a way to establish a surveillance system for genital warts among the Hong Kong general population. Methods A total of 170 private doctors and all doctors working in the 5 local Social Hygiene Clinics (SHC) participated in this study. During the 14-day data collection period (January 5 through18, 2009), the participating doctors filled out a log-form on a daily basis to record the number of patients with genital warts. The total number of new cases of genital warts presented to private and public doctors in Hong Kong was projected using the stratification sampling method. Results A total of 721 (0.94%) adults presented with genital warts to the participating doctors during the two-week study period, amongst them 73 (10.1%) were new cases. The projected number of new cases of genital warts among Hong Kong adults was 442 (297 male and 144 female) during the study period. The incidence of genital warts in Hong Kong was estimated to be 203.7 per 100,000 person-years (respectively 292.2 and 124.9 per 100,000 person-years for males and females). Conclusions The incidence of genital warts is high among adults in Hong Kong. The study demonstrates the importance of collecting surveillance data from both private and public sectors. PMID:20849578

  3. Preserving the literary past, looking to the future:the first Hong Kong Literature Database

    Institute of Scientific and Technical Information of China (English)

    MA Leo F.H.; WONG Rita; LAU Paul

    2005-01-01

    In the last two decades of the 20th century, there has been an increasing interest in and emphasis on the study of the Hong Kong literature in both the academic and general public in Hong Kong. Recognizing the emergent need of the resources on Hong Kong literature, the University Library System of the Chinese University of Hong Kong set up the Hong Kong Literature Database (the "Database"), which was the first Chinese literature database in the Internet in 2000. The paper will examine how the database is constructed using XML technology and metadata schema. The database also employs Unicode UTF-8 as the internal code. A mapping table fortraditional and simplified Chinese characters wascreated based on Unihan and is used behind the scene so that a user can either input traditional or simplified Chinese characters and retrieval will give both traditional and simplified Chinese characters. Currently 65% of journals use OCR technology so that full-text searching is possible. The Chinese OCR technology will be examined in greater detail. Special features of the Database such as, page-by-page browse mode, position-highlight for full-page newspaper, linking Table-Of-Contents and bnokjackets from the Library catalogue, etc. are described.The paper will also bring out the problem of massive downloading and compare the state-of-the-art technology and their shortcomings. This paper shows how the Hong Kong Literature Database facilitates future collaboration and data exchange by using open standard, shareable structure and the latest technology.

  4. Epidemiology of Open-Globe Injuries in Hong Kong.

    Science.gov (United States)

    Li, Emmy Y; Chan, Tommy C; Liu, Andrea T; Yuen, Hunter K

    2017-01-01

    The aim of this study was to review the epidemiology and clinical outcomes of open-globe injuries (OGIs) in Hong Kong over a 10-year period. Retrospective case-review. This study included patients with OGI who presented to Hong Kong Eye Hospital and Queen Elizabeth Hospital from 1999 to 2008. Patient demographics, causes and mechanisms of injury, visual acuity (VA) at presentation, clinical features, and final VA were collected. Univariate and multivariate analyses using logistic regression were performed to identify poor prognostic factors. A total of 122 eyes of 121 patients were included. More than half (63%) were male, and the mean age was 54 years. Workplace injuries (36%) ranked first, followed by fall (32%) and assault (13%). The majority (66%) presented with VA less than 5/200. Common associations included hyphema, lens damage, uveal prolapse, and vitreous hemorrhage. Overall, about half (46%) sustained profound visual loss (final VA <5/200). Twelve eyes underwent evisceration or enucleation. Only 1 eye developed endophthalmitis. Univariate analysis suggested that profound visual loss was associated with poor initial VA, relative afferent pupillary defect, and posterior scleral involvement (P < 0.05). Multivariate analysis showed that poor initial VA and posterior involvement were independent poor prognostic factors. Profound visual loss was common after OGIs, especially in cases with poor vision at presentation and involvement of the posterior sclera. Identifying poor prognostic factors helps guide clinical management and facilitates counseling for patients. Early medical and surgical treatment may help to reduce the risk of endophthalmitis. Copyright© 2017 Asia-Pacific Academy of Ophthalmology.

  5. Retrospective space-time analysis of H5N1 Avian Influenza emergence in Thailand

    Directory of Open Access Journals (Sweden)

    Shanmugasundaram Jothiganesh

    2010-01-01

    Full Text Available Abstract Background The highly pathogenic avian influenza (HPAI H5N1 virus remains a worldwide threat to human and animal health, while the mechanisms explaining its epizootic emergence and re-emergence in poultry are largely unknown. Data from Thailand, a country that experienced significant epidemics in poultry and has recorded suspicious cases of HPAI on a daily basis since 2004, are used here to study the process of emergence. A spatial approach is employed to describe all HPAI H5N1 virus epizootics from 2004 to 2008 and to characterize the pattern of emergence: multiple independent introductions of the virus followed by moderate local spread vs. very rare emergences followed by strong local spread and rare long range diffusion jumps. Sites where epizootics originate (by foreign introduction, local persistence, or long range jump were selected from those to which the disease subsequently spreads using a filter based on relative date and position. The spatial distribution of these selected foci was statistically analyzed, and to differentiate environmental factors from long range diffusion, we investigate the relationship of these foci with environmental exposure factors and with rearing characteristics. Results During each wave of epizootics, the temporal occurrence of cases did not show a temporal interruption of more than a week. All foci were globally clustered; i.e., more than 90% of cases had a previous case within a 10 km range and a 21 day period of time, showing a strong local spread. We were able to estimate 60 km as the maximum distance for the local farm to farm dissemination process. The remaining "emergent" cases have occurred randomly over Thailand and did not show specific location, clusters, or trends. We found that these foci are not statistically related to specific environmental conditions or land cover characteristics, and most of them may be interpreted as long range diffusion jumps due to commercial practices

  6. Dietary exposure to dioxins and dioxin-like PCBs of Hong Kong adults: results of the first Hong Kong Total Diet Study.

    Science.gov (United States)

    Wong, Waiky W K; Yip, Yiu-chung; Choi, Koon-kay; Ho, Y Y; Xiao, Ying

    2013-01-01

    Dioxins and dioxin-like polychlorinated biphenyls (PCBs) are persistent organic pollutants (POPs) covered by the Stockholm Convention on POPs. To assess the associated health risk of the Hong Kong population, the dietary exposure of the Hong Kong population and various age-gender subgroups to dioxins and dioxin-like PCBs was estimated in the first Hong Kong Total Diet Study (TDS), where food samples were collected and prepared "as consumed". A total of 142 composite food samples, mainly foods of animal origin and their products and oily food, were analysed for polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs) and dioxin-like PCBs by the high-resolution gas chromatograph/high-resolution mass spectrometer (HRGC/HRMS) system. Dietary exposures were estimated by combining the analytical results with the food consumption data of Hong Kong adults. The mean and 95th percentile exposures to dioxins and dioxin-like PCBs of the Hong Kong population were 21.9 and 59.7 pg toxic equivalent (TEQ) kg⁻¹ body weight (bw) month⁻¹ respectively, which amounted to 31.3% and 85.2% of the provisional tolerable monthly intake (PTMI). The main dietary source of dioxins and dioxin-like PCBs was "Fish and seafood and their products" (61.9% of the total exposure), followed by "Meat, poultry and game and their products" (20.0%) and "Mixed dishes" (6.95%). The study findings suggest that the Hong Kong population is unlikely to experience the major undesirable health effects of dioxins and dioxin-like PCBs.

  7. Evolutionary features of influenza A/H5N1 virus populations in Egypt: poultry and human health implications.

    Science.gov (United States)

    Naguib, Mahmoud M; Abdelwhab, E M; Harder, Timm C

    2016-07-01

    Since 2006, in Egypt, highly pathogenic avian influenza virus (HPAIV) H5N1 has established endemic status in poultry. Bayesian evolutionary analysis sampling trees suggested an introduction date in the third quarter of 2005. Evolutionary dynamics using Bayesian analysis showed that H5N1 viruses of clade 2.2.1.1 evolved at higher rates than those of clade 2.2.1.2. Bayesian skyline plot analysis of the HA gene of 840 and NA gene of 401 Egyptian H5N1 viruses from 2006-2015 identified two waves of viral population expansion correlating with the stepwise emergence of the 2.2.1.1 variant lineage in 2008 and with the newly emerging 2.2.1.2 cluster in late 2014. H5N1 infections in human hosts in 2014-2015 were statistically linked to a contemporary poultry outbreak.

  8. Fluorescence biosensor based on CdTe quantum dots for specific detection of H5N1 avian influenza virus

    Science.gov (United States)

    Hoa Nguyen, Thi; Dieu Thuy Ung, Thi; Hien Vu, Thi; Tran, Thi Kim Chi; Quyen Dong, Van; Khang Dinh, Duy; Liem Nguyen, Quang

    2012-09-01

    This report highlights the fabrication of fluorescence biosensors based on CdTe quantum dots (QDs) for specific detection of H5N1 avian influenza virus. The core biosensor was composed of (i) the highly luminescent CdTe/CdS QDs, (ii) chromatophores extracted from bacteria Rhodospirillum rubrum, and (iii) the antibody of β-subunit. This core part was linked to the peripheral part of the biosensor via a biotin-streptavidin-biotin bridge and finally connected to the H5N1 antibody to make it ready for detecting H5N1 avian influenza virus. Detailed studies of each constituent were performed showing the image of QDs-labeled chromatophores under optical microscope, proper photoluminescence (PL) spectra of CdTe/CdS QDs, chromatophores and the H5N1 avian influenza viruses.

  9. Molecular analysis of Hemagglutinin Gen of Highly Pathogenic Avian Influenza of H5N1 Subtype Isolated from Waterfowls

    National Research Council Canada - National Science Library

    R Susanti; Retno D Soejoedono; I Gusti Ngurah K Mahardika; I Wayan T Wibawan; Maggy T Suhartono

    2008-01-01

    Avian influenza viruses (AIV) subtype H5N1 isolated from waterfowls in West Java pose the known characteristic of highly pathogenic strains, with polybasic amino acid sequence of cleavage site QRERRRKKR and QRESRRKKR...

  10. Predicted epitopes of H5N1 bird flu virus by bioinformatics method: a clue for further vaccine development

    Institute of Scientific and Technical Information of China (English)

    Viroj Wiwnanitkit

    2006-01-01

    @@ To the Editor: Bird flu or avian flu, caused by H5N1 virus, is a new emerging infectious disease. It is noted that this H5N1 virus jumped the species barrier and caused severe disease with high mortality in humans in many countries. The continued westward dissemination of H5N1 influenza A viruses in avian populations and the nearly 50% mortality of humans infected with H5N1 are a source of great international concern.1Providing sufficient antiviral drugs and development and approval of new vaccines are the keys for control of the possible emerging pandemic of this atypical influenza.1,2 Based on the advance in bioinformatics, the immunomics becomes a new alternative in vaccine development.3

  11. Rapid Emergence of Highly Pathogenic Avian Influenza Subtypes from a Subtype H5N1 Hemagglutinin Variant.

    Science.gov (United States)

    de Vries, Erik; Guo, Hongbo; Dai, Meiling; Rottier, Peter J M; van Kuppeveld, Frank J M; de Haan, Cornelis A M

    2015-05-01

    In 2014, novel highly pathogenic avian influenza A H5N2, H5N5, H5N6, and H5N8 viruses caused outbreaks in Asia, Europe, and North America. The H5 genes of these viruses form a monophyletic group that evolved from a clade 2.3.4 H5N1 variant. This rapid emergence of new H5Nx combinations is unprecedented in the H5N1 evolutionary history.

  12. Avian influenza (H5N1 virus of clade 2.3.2 in domestic poultry in India.

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    Shanmuga Nagarajan

    Full Text Available South Asia has experienced regular outbreaks of H5N1 avian influenza virus since its first detection in India and Pakistan in February, 2006. Till 2009, the outbreaks in this region were due to clade 2.2 H5N1 virus. In 2010, Nepal reported the first outbreak of clade 2.3.2 virus in South Asia. In February 2011, two outbreaks of H5N1 virus were reported in the State of Tripura in India. The antigenic and genetic analyses of seven H5N1 viruses isolated during these outbreaks were carried out. Antigenic analysis confirmed 64 to 256-fold reduction in cross reactivity compared with clade 2.2 viruses. The intravenous pathogenicity index of the isolates ranged from 2.80-2.95 indicating high pathogenicity to chickens. Sequencing of all the eight gene-segments of seven H5N1 viruses isolated in these outbreaks was carried out. The predicted amino acid sequence analysis revealed high pathogenicity to chickens and susceptibility to the antivirals, amantadine and oseltamivir. Phylogenetic analyses indicated that these viruses belong to clade 2.3.2.1 and were distinct to the clade 2.3.2.1 viruses isolated in Nepal. Identification of new clade 2.3.2 H5N1 viruses in South Asia is reminiscent of the introduction of clade 2.2 viruses in this region in 2006/7. It is now important to monitor whether the clade 2.3.2.1 is replacing clade 2.2 in this region or co-circulating with it. Continued co-circulation of various subclades of the H5N1 virus which are more adapted to land based poultry in a highly populated region such as South Asia increases the risk of evolution of pandemic H5N1 strains.

  13. Migration of whooper swans and outbreaks of highly pathogenic avian influenza H5N1 virus in Eastern Asia

    Science.gov (United States)

    Newman, Scott H.; Iverson, Samuel A.; Takekawa, John Y.; Gilbert, Martin; Prosser, Diann J.; Batbayar, Nyambyar; Natsagdorj, Tseveenmyadag; Douglas, David C.

    2009-01-01

    Evaluating the potential involvement of wild avifauna in the emergence of highly pathogenic avian influenza H5N1 (hereafter H5N1) requires detailed analyses of temporal and spatial relationships between wild bird movements and disease emergence. The death of wild swans (Cygnus spp.) has been the first indicator of the presence of H5N1 in various Asian and European countries; however their role in the geographic spread of the disease remains poorly understood. We marked 10 whooper swans (Cygnus cygnus) with GPS transmitters in northeastern Mongolia during autumn 2006 and tracked their migratory movements in relation to H5N1 outbreaks. The prevalence of H5N1 outbreaks among poultry in eastern Asia during 2003-2007 peaked during winter, concurrent with whooper swan movements into regions of high poultry density. However outbreaks involving poultry were detected year round, indicating disease perpetuation independent of migratory waterbird presence. In contrast, H5N1 outbreaks involving whooper swans, as well as other migratory waterbirds that succumbed to the disease in eastern Asia, tended to occur during seasons (late spring and summer) and in habitats (areas of natural vegetation) where their potential for contact with poultry is very low to nonexistent. Given what is known about the susceptibility of swans to H5N1, and on the basis of the chronology and rates of whooper swan migration movements, we conclude that although there is broad spatial overlap between whooper swan distributions and H5N1 outbreak locations in eastern Asia, the likelihood of direct transmission between these groups is extremely low. Thus, our data support the hypothesis that swans are best viewed as sentinel species, and moreover, that in eastern Asia, it is most likely that their infections occurred through contact with asymptomatic migratory hosts (e.g., wild ducks) at or near their breeding grounds.

  14. Clinical characteristics of 26 human cases of highly pathogenic avian influenza A (H5N1 virus infection in China.

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    Hongjie Yu

    Full Text Available BACKGROUND: While human cases of highly pathogenic avian influenza A (H5N1 virus infection continue to increase globally, available clinical data on H5N1 cases are limited. We conducted a retrospective study of 26 confirmed human H5N1 cases identified through surveillance in China from October 2005 through April 2008. METHODOLOGY/PRINCIPAL FINDINGS: Data were collected from hospital medical records of H5N1 cases and analyzed. The median age was 29 years (range 6-62 and 58% were female. Many H5N1 cases reported fever (92% and cough (58% at illness onset, and had lower respiratory findings of tachypnea and dyspnea at admission. All cases progressed rapidly to bilateral pneumonia. Clinical complications included acute respiratory distress syndrome (ARDS, 81%, cardiac failure (50%, elevated aminotransaminases (43%, and renal dysfunction (17%. Fatal cases had a lower median nadir platelet count (64.5 x 10(9 cells/L vs 93.0 x 10(9 cells/L, p = 0.02, higher median peak lactic dehydrogenase (LDH level (1982.5 U/L vs 1230.0 U/L, p = 0.001, higher percentage of ARDS (94% [n = 16] vs 56% [n = 5], p = 0.034 and more frequent cardiac failure (71% [n = 12] vs 11% [n = 1], p = 0.011 than nonfatal cases. A higher proportion of patients who received antiviral drugs survived compared to untreated (67% [8/12] vs 7% [1/14], p = 0.003. CONCLUSIONS/SIGNIFICANCE: The clinical course of Chinese H5N1 cases is characterized by fever and cough initially, with rapid progression to lower respiratory disease. Decreased platelet count, elevated LDH level, ARDS and cardiac failure were associated with fatal outcomes. Clinical management of H5N1 cases should be standardized in China to include early antiviral treatment for suspected H5N1 cases.

  15. Predominance and geo-mapping of avian influenza H5N1 in poultry sectors in Egypt

    Directory of Open Access Journals (Sweden)

    Abdelsatar Arafa

    2016-11-01

    Full Text Available Highly pathogenic avian influenza (HPAI virus of the H5N1 subtype has been enzootic in the Egyptian poultry with significant human infections since 2008. This work evaluates the epidemiological and virological information from February 2006 to May 2015 in spatial and temporal terms. Only data with confirmed HPAI H5N1 sub-type were collected, and matched with the epidemiological data from various spatially and temporally-dispersed surveillances implemented between 2006 and 2015. Spatio-temporal analysis was conducted on a total of 3338 confirmed H5N1 HPAI poultry disease outbreaks and outputs described based on transmission patterns, poultry species, production types affected, trade, geographic and temporal distributions in Egypt. The H5N1 virus persists in the Egyptian poultry displaying a seasonal pattern with peak prevalence between January and March. There was no specific geographic pattern, but chickens and ducks were more affected. However, relatively higher disease incidences were recorded in the Nile Delta. Phylogenetic studies of the haemagglutinin gene sequences of H5N1 viruses indicated that multiple clusters circulated between 2006 and 2015, with significant deviations in circulation. Epidemiological dynamics of HPAI has changed with the origins of majority of outbreaks shifted to household poultry. The persistence of HPAI H5N1 in poultry with recurrent and sporadic infections in humans can influence virus evolution spatio-temporally. Household poultry plays significant roles in the H5N1 virus transmission to poultry and humans, but the role of commercial poultry needs further clarifications. While poultry trading supports the persistence and transmission of H5N1, the role of individual species may warrant further investigation. Surveillance activities, applying a multi-sectoral approach, are recommended.

  16. Progress toward a universal H5N1 vaccine: a recombinant modified vaccinia virus Ankara-expressing trivalent hemagglutinin vaccine.

    Directory of Open Access Journals (Sweden)

    Mookkan Prabakaran

    Full Text Available The rapid evolution of new sublineages of H5N1 influenza poses the greatest challenge in control of H5N1 infection by currently existing vaccines. To overcome this, an MVAtor vector expressing three H5HA antigens A/Vietnam/1203/04, A/Indonesia/669/06 and A/Anhui/01/05 (MVAtor-tri-HA vector was developed to elicit broad cross-protection against diverse clades by covering amino acid variations in the major neutralizing epitopes of HA among H5N1 subtypes.BALB/c mice and guinea pigs were immunized i.m. with 8×107 TCID50/animal of MVAtor-tri-HA vector. The immunogenicity and cross-protective immunity of the MVAtor-tri-HA vector was evaluated against diverse clades of H5N1 strains.The results showed that mice immunized with MVAtor-tri-HA vector induced robust cross-neutralizing immunity to diverse H5N1 clades. In addition, the MVAtor-tri-HA vector completely protected against 10 MLD50 of a divergent clade of H5N1 infection (clade 7. Importantly, the serological surveillance of post-vaccinated guinea pig sera demonstrated that MVAtor-tri-HA vector was able to elicit strong cross-clade neutralizing immunity against twenty different H5N1 strains from six clades that emerged between 1997 and 2012.The present findings revealed that incorporation of carefully selected HA genes from divergent H5N1 strains within a single vector could be an effective approach in developing a vaccine with broad coverage to prevent infection during a pandemic situation.

  17. Genetic Characterization of Clade 2.3.2.1 Avian Influenza A(H5N1) Viruses, Indonesia, 2012

    Science.gov (United States)

    Hartawan, Risza; Pudjiatmoko; Wibawa, Hendra; Hardiman; Balish, Amanda; Donis, Ruben; Davis, C. Todd; Samaan, Gina

    2014-01-01

    After reports of unusually high mortality rates among ducks on farms in Java Island, Indonesia, in September 2012, influenza A(H5N1) viruses were detected and characterized. Sequence analyses revealed all genes clustered with contemporary clade 2.3.2.1 viruses, rather than enzootic clade 2.1.3 viruses, indicating the introduction of an exotic H5N1 clade into Indonesia. PMID:24656213

  18. Self-Esteem: A Comparison between Hong Kong Children and Newly Arrived Chinese Children

    Science.gov (United States)

    Chan, Yiu Man; Chan, Christine Mei-Sheung

    2004-01-01

    The Self-esteem Inventory developed by Coopersmith (1967) was used to measure the self-esteem of 387 Chinese children. The sample included newly arrived mainland Chinese children and Hong Kong children. The results showed significant statistical differences when measuring the self-esteem level associated with the length of their stay in Hong Kong…

  19. Radiological and clinical course of pneumonia in patients with avian influenza H5N1

    Energy Technology Data Exchange (ETDEWEB)

    Bay, Ali [Yuzuncu Yil University, Faculty of Medicine, Department of Pediatrics, Van (Turkey)]. E-mail: bayalibay@yahoo.com; Etlik, Omer [Yuzuncu Yil University, Faculty of Medicine, Department of Radiology, Van (Turkey); Oner, A. Faik [Yuzuncu Yil University, Faculty of Medicine, Department of Pediatrics, Van (Turkey); Unal, Ozkan [Yuzuncu Yil University, Faculty of Medicine, Department of Radiology, Van (Turkey); Arslan, Halil [Yuzuncu Yil University, Faculty of Medicine, Department of Radiology, Van (Turkey); Bora, Aydin [Yuzuncu Yil University, Faculty of Medicine, Department of Radiology, Van (Turkey); Davran, Ramazan [Yuzuncu Yil University, Faculty of Medicine, Department of Radiology, Van (Turkey); Yuca, Sevil Ari [Yuzuncu Yil University, Faculty of Medicine, Department of Pediatrics, Van (Turkey); Dogan, Murat [Yuzuncu Yil University, Faculty of Medicine, Department of Pediatrics, Van (Turkey)

    2007-02-15

    Introduction: We evaluated chest X-ray and clinical findings of patients with lower respiratory tract infection due to influenza H5N1 and presented the radiological findings and clinical course of the infection. Materials and methods: Between December 2005 and February 2006, eight hospitalized patients (median age 10, 5-15 years) with avian-flu were evaluated in this study. All patients were evaluated with chest X-ray and four of them with CT scan. Post mortem pathological characterization were also available for three of the patients. Results: A rapidly progressive pneumonia with high mortality rate was observed especially for cases with late admission. The major radiologic abnormalities were extensive pneumonic infiltration with segmental and multifocal distribution, mostly located in lower zones of the lung. No pleural effusion and hilar lymphadenopathy was noted. Conclusion: Avian flu may be presented as rapidly progressive pneumonia. The chest radiography has an important role in diagnosis and should be obtained daily because of rapid change of the findings that may necessitate prompt action.

  20. The antigenic property of the H5N1 avian influenza viruses isolated in central China

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    Zou Wei

    2012-08-01

    Full Text Available Abstract Background Three influenza pandemics outbroke in the last century accompanied the viral antigen shift and drift, resulting in the change of antigenic property and the low cross protective ability of the existed antibody to the newly emerged pandemic virus, and eventually the death of millions of people. The antigenic characterizations of the viruses isolated in central China in 2004 and 2006–2007 were investigated in the present study. Results Hemagglutinin inhibition assay and neutralization assay displayed differential antigenic characteristics of the viruses isolated in central China in two periods (2004 and 2006–2007. HA genes of the viruses mainly located in two branches in phylogeny analysis. 53 mutations of the deduced amino acids of the HA genes were divided into 4 patterns. Mutations in pattern 2 and 3 showed the main difference between viruses isolated in 2004 and 2006–2007. Meanwhile, most amino acids in pattern 2 and 3 located in the globular head of the HA protein, and some of the mutations evenly distributed at the epitope sites. Conclusions The study demonstrated that a major antigenic drift had occurred in the viruses isolated in central China. And monitoring the antigenic property should be the priority in preventing the potential pandemic of H5N1 avian influenza virus.

  1. Avian influenza H5N1 vaccination efficacy in Egyptian backyard poultry.

    Science.gov (United States)

    Kandeil, Ahmed; Mostafa, Ahmed; El-Shesheny, Rabeh; El-Taweel, Ahmed Nageh; Gomaa, Mokhtar; Galal, Hussein; Kayali, Ghazi; Ali, Mohamed A

    2017-09-25

    Raising backyard poultry under low biosecurity conditions is a common practice in Egypt. While vaccination is routinely applied in Egypt in commercial settings to curb the spread of avian influenza viruses, it remains less commonly used in backyard settings. We assessed the immunogenicity and protective efficacy of a H5N1 vaccine based on a contemporary Egyptian clade 2.2.1.2 virus among turkeys, ducks, geese, and chickens raised together in a backyard setting. Results showed that this vaccine elicits an immune response in all tested species reaching up to a hemagglutination inhibition titer of 10 log2 after a booster dose. However, this response varied between species. When challenged, vaccinated birds survived and shed less virus in comparison with unvaccinated birds. However, unvaccinated ducks showed no symptoms of infection and survived the duration of the experiment. Moreover, vaccinated ducks shed more virus as compared to vaccinated birds of other species. Hence, we recommend avoiding mixing various species in the backyards of Egypt. Our data indicates that vaccination can be effective in the backyard setting in Egypt, although planning should consider the species covered. Copyright © 2017 Elsevier Ltd. All rights reserved.

  2. H5N1 Avian Influenza Pre-pandemic Vaccine Strains in China

    Institute of Scientific and Technical Information of China (English)

    BO Hong; DONG Li Bo; ZHANG Ye; DONG Jie; ZOU Shu Mei; GAO Rong Bao; WANG Da Yan; SHU Yue Long

    2014-01-01

    ObjectiveTo prepare the 4 candidate vaccine strains of H5N1 avian influenza virus isolated in China. MethodsRecombinant viruses were rescued using reverse genetics. Neuraminidase (NA) and hemagglutinin (HA) segments of the A/Xinjiang/1/2006, A/Guangxi/1/2009, A/Hubei/1/2010, and A/Guangdong/1/2011 viruses were amplified by RT-PCR. Multibasic amino acid cleavage site of HA was removed and ligated into the pCIpolI vector for virus rescue. The recombinant viruses were evaluated by trypsin dependent assays. Their embryonate survival and antigenicity were compared with those of the respective wild-type viruses. ResultsThe 4 recombinant viruses showed similar antigenicity compared with wild-type viruses, chickenembryo survival and trypsin-dependent characteristics. ConclusionThe 4 recombinantviruses rescued using reverse genetics meet the criteria for classification of low pathogenic avian influenza strains, thus supporting the use of them for the development of seeds and production of pre-pandemic vaccines.

  3. Survival of H5N1 influenza virus in water and its inactivation by chemical methods.

    Science.gov (United States)

    Mihai, Maria Elena; Tecu, Cristina; Ivanciuc, Alina Elena; Necula, Gheorghe; Lupulescu, Emilia; Onu, Adrian

    2011-01-01

    The ability of H5N1 Avian Influenza Virus (AIV) to survive in surface water has been assessed in experimental laboratory conditions, based on non-pathogenic avian reassortant model, by titration of infectivity (TCID50) at different time intervals, in three different types of water. The effect of different chemicals on AIV's survival was assessed using the same type of experimental model. After exposure to the chemical, followed by growth on a suitable substrate, the AIV was quantified by a real-time quantitative reverse transcriptase PCR (qRT-PCR). The reassortant virus persisted, and remained infective in aquatic environments, for 12 days at 22-35 degrees C and up to 20 days at 4 degrees C, irrespective of the type of water, supporting the hypothesis of a potential risk for transmitting the virus among birds and contaminating the household water via common sources of water. A significant decrease for AIV persistence models was recorded for sea water, after 12 days, at 35 degrees C. An effective inactivation has been shown when using commercially available products based on glutaraldehyde and penta potassium bis (peroxy mono sulphate) bis(sulphate), respectively. This rapid and safe method for decontamination, developed in this study, might be helpful in implementation of biosafety measures in laboratory and farms against AIV.

  4. Phylogenetic and pathogenic analyses of avian influenza A H5N1 viruses isolated from poultry in Vietnam.

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    Dongming Zhao

    Full Text Available Despite great efforts to control the infection of poultry with H5N1 viruses, these pathogens continue to evolve and spread in nature, threatening public health. Elucidating the characteristics of H5N1 avian influenza virus will benefit disease control and pandemic preparation. Here, we sequenced the genomes of 15 H5N1 avian influenza viruses isolated in Vietnam in 2006 and 2007 and performed phylogenetic analyses to compare these sequences with those of other viruses available in the public databases. Molecular characterization of the H5N1 viruses revealed that seven genetically distinct clades of H5N1 viruses have appeared in Vietnam. Clade 2.3.4 viruses existed in Vietnam as early as 2005. Fifteen viruses isolated during 2006 and 2007 belonged to clade 1 and clade 2.3.4, and were divided into five genotypes. Reassortants between the clade 1 and clade 2.3.4 viruses were detected in both North and South Vietnam. We also assessed the replication and pathogenicity of these viruses in mice and found that these isolates replicated efficiently and exhibited distinct virulence in mice. Our results provide important information regarding the diversity of H5N1 viruses in nature.

  5. Highly Pathogenic Avian Influenza A(H5N1) Virus Struck Migratory Birds in China in 2015.

    Science.gov (United States)

    Bi, Yuhai; Zhang, Zhenjie; Liu, Wenjun; Yin, Yanbo; Hong, Jianmin; Li, Xiangdong; Wang, Haiming; Wong, Gary; Chen, Jianjun; Li, Yunfeng; Ru, Wendong; Gao, Ruyi; Liu, Di; Liu, Yingxia; Zhou, Boping; Gao, George F; Shi, Weifeng; Lei, Fumin

    2015-08-11

    Approximately 100 migratory birds, including whooper swans and pochards, were found dead in the Sanmenxia Reservoir Area of China during January 2015. The causative agent behind this outbreak was identified as H5N1 highly pathogenic avian influenza virus (HPAIV). Genetic and phylogenetic analyses revealed that this Sanmenxia H5N1 virus was a novel reassortant, possessing a Clade 2.3.2.1c HA gene and a H9N2-derived PB2 gene. Sanmenxia Clade 2.3.2.1c-like H5N1 viruses possess the closest genetic identity to A/Alberta/01/2014 (H5N1), which recently caused a fatal respiratory infection in Canada with signs of meningoencephalitis, a highly unusual symptom with influenza infections in humans. Furthermore, this virus was shown to be highly pathogenic to both birds and mammals, and demonstrate tropism for the nervous system. Due to the geographical location of Sanmenxia, these novel H5N1 viruses also have the potential to be imported to other regions through the migration of wild birds, similar to the H5N1 outbreak amongst migratory birds in Qinghai Lake during 2005. Therefore, further investigation and monitoring is required to prevent this novel reassortant virus from becoming a new threat to public health.

  6. Satellite-marked waterfowl reveal migratory connection between H5N1 outbreak areas in China and Mongolia

    Science.gov (United States)

    Prosser, D.J.; Takekawa, J.Y.; Newman, S.H.; Yan, B.; Douglas, D.C.; Hou, Y.; Xing, Z.; Zhang, Dongxiao; Li, T.; Li, Y.; Zhao, D.; Perry, W.M.; Palm, E.C.

    2009-01-01

    The role of wild birds in the spread of highly pathogenic avian influenza H5N1 has been greatly debated and remains an unresolved question. However, analyses to determine involvement of wild birds have been hindered by the lack of basic information on their movements in central Asia. Thus, we initiated a programme to document migrations of waterfowl in Asian flyways to inform hypotheses of H5N1 transmission. As part of this work, we studied migration of waterfowl from Qinghai Lake, China, site of the 2005 H5N1 outbreak in wild birds. We examined the null hypothesis that no direct migratory connection existed between Qinghai Lake and H5N1 outbreak areas in central Mongolia, as suggested by some H5N1 phylogeny studies. We captured individuals in 2007 from two of the species that died in the Qinghai Lake outbreaks and marked them with GPS satellite transmitters: Bar-headed Geese Anser indicus (n = 14) and Ruddy Shelduck Tadorna ferruginea (n = 11). Three of 25 marked birds (one Goose and two Shelducks) migrated to breeding grounds near H5N1 outbreak areas in Mongolia. Our results describe a previously unknown migratory link between the two regions and offer new critical information on migratory movements in the region. ?? 2009 British Ornithologists' Union.

  7. Seroprevalence of antibodies against highly pathogenic avian influenza A (H5N1 virus among poultry workers in Bangladesh, 2009.

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    Sharifa Nasreen

    Full Text Available We conducted a cross-sectional study in 2009 to determine the seroprevalence and risk factors for highly pathogenic avian influenza A (H5N1 [HPAI H5N1] virus antibodies among poultry workers at farms and live bird markets with confirmed/suspected poultry outbreaks during 2009 in Bangladesh. We tested sera by microneutralization assay using A/Bangladesh/207095/2008 (H5N1; clade 2.2.2 virus with confirmation by horse red blood cell hemagglutination inhibition and H5-specific Western blot assays. We enrolled 212 workers from 87 farms and 210 workers from three live bird markets. One hundred and two farm workers (48% culled poultry. One hundred and ninety-three farm workers (91% and 178 market workers (85% reported direct contact with poultry that died during a laboratory confirmed HPAI H5N1 poultry farm outbreak or market poultry die-offs from suspected HPAI H5N1. Despite exposure to sick poultry, no farm or market poultry workers were seropositive for HPAI H5N1 virus antibodies (95% confidence interval 0-1%.

  8. Lethal infection by a novel reassortant H5N1 avian influenza A virus in a zoo-housed tiger.

    Science.gov (United States)

    He, Shang; Shi, Jianzhong; Qi, Xian; Huang, Guoqing; Chen, Hualan; Lu, Chengping

    2015-01-01

    In early 2013, a Bengal tiger (Panthera tigris) in a zoo died of respiratory distress. All specimens from the tiger were positive for HPAI H5N1, which were detected by real-time PCR, including nose swab, throat swab, tracheal swab, heart, liver, spleen, lung, kidney, aquae pericardii and cerebrospinal fluid. One stain of virus, A/Tiger/JS/1/2013, was isolated from the lung sample. Pathogenicity experiments showed that the isolate was able to replicate and cause death in mice. Phylogenetic analysis indicated that HA and NA of A/Tiger/JS/1/2013 clustered with A/duck/Vietnam/OIE-2202/2012 (H5N1), which belongs to clade 2.3.2.1. Interestingly, the gene segment PB2 shared 98% homology with A/wild duck/Korea/CSM-28/20/2010 (H4N6), which suggested that A/Tiger/JS/1/2013 is a novel reassortant H5N1 subtype virus. Immunohistochemical analysis also confirmed that the tiger was infected by this new reassortant HPAI H5N1 virus. Overall, our results showed that this Bengal tiger was infected by a novel reassortant H5N1, suggesting that the H5N1 virus can successfully cross species barriers from avian to mammal through reassortment.

  9. Influenza A virus H5N1 entry into host cells is through clathrin-dependent endocytosis

    Institute of Scientific and Technical Information of China (English)

    WANG HongLiang; JIANG ChengYu

    2009-01-01

    Influenza A virus H5N1 presents a major threat to human health. The entry of influenza virus into host cells is believed to be mediated by hemagglutinin (HA), a virus surface glycoprotein that can bind ter-minal sialic acid residues on host cell glycoproteins and glycolipids. In this study, we elucidated the pathways through which H5N1 enters human lung carcinoma cell line A549. We first proved that H5N1 can enter A549 cells via endocytosis, as lysosomotropic agents, such as bafilomycin A1 and chloro. quine, can rescue H5Nl-induced A549 cell death. By using specific inhibitors, and siRNAs that target the clathrin pathway, we further found that H5N1 could enter A549 cells via clathrin-mediated endocy-tosis, while inhibitors targeting caveolae-mediated endocytosis could not inhibit H5N1 cell entry. These findings expand our understanding of H5N1 pathogenesis and provide new information for anti-viral drug research.

  10. Continual Antigenic Diversification in China Leads to Global Antigenic Complexity of Avian Influenza H5N1 Viruses

    Science.gov (United States)

    Peng, Yousong; Li, Xiaodan; Zhou, Hongbo; Wu, Aiping; Dong, Libo; Zhang, Ye; Gao, Rongbao; Bo, Hong; Yang, Lei; Wang, Dayan; Lin, Xian; Jin, Meilin; Shu, Yuelong; Jiang, Taijiao

    2017-01-01

    The highly pathogenic avian influenza (HPAI) H5N1 virus poses a significant potential threat to human society due to its wide spread and rapid evolution. In this study, we present a comprehensive antigenic map for HPAI H5N1 viruses including 218 newly sequenced isolates from diverse regions of mainland China, by computationally separating almost all HPAI H5N1 viruses into 15 major antigenic clusters (ACs) based on their hemagglutinin sequences. Phylogenetic analysis showed that 12 of these 15 ACs originated in China in a divergent pattern. Further analysis of the dissemination of HPAI H5N1 virus in China identified that the virus’s geographic expansion was co-incident with a significant divergence in antigenicity. Moreover, this antigenic diversification leads to global antigenic complexity, as typified by the recent HPAI H5N1 spread, showing extensive co-circulation and local persistence. This analysis has highlighted the challenge in H5N1 prevention and control that requires different planning strategies even inside China. PMID:28262734

  11. Ecologic risk factor investigation of clusters of avian influenza A (H5N1) virus infection in Thailand.

    Science.gov (United States)

    Tiensin, Thanawat; Ahmed, Syed Sayeem Uddin; Rojanasthien, Suvichai; Songserm, Thaweesak; Ratanakorn, Parntep; Chaichoun, Kridsada; Kalpravidh, Wantanee; Wongkasemjit, Surapong; Patchimasiri, Tuangthong; Chanachai, Karoon; Thanapongtham, Weerapong; Chotinan, Suwit; Stegeman, Arjan; Nielen, Mirjam

    2009-06-15

    This study was conducted to investigate space and time clusters of highly pathogenic avian influenza A (H5N1) virus infection and to determine risk factors at the subdistrict level in Thailand. Highly pathogenic avian influenza A (H5N1) was diagnosed in 1890 poultry flocks located in 953 subdistricts during 2004-2007. The ecologic risk for H5N1 virus infection was assessed on the basis of a spatial-based case-control study involving 824 case subdistricts and 3296 control subdistricts from 6 study periods. Risk factors investigated in clustered areas of H5N1 included human and animal demographic characteristics, poultry production systems, and wild birds and their habitats. Six variables remained statistically significant in the final model: flock density of backyard chickens (odds ratio [OR], 0.98), flock density of fighting cocks (OR, 1.02), low and high human density (OR, 0.60), presence of quail flocks (OR, 1.21), free-grazing duck flocks (OR, 2.17), and a poultry slaughterhouse (OR, 1.33). We observed a strong association between subdistricts with H5N1 virus-infected poultry flocks and evidence of prior and concomitant H5N1 infection in wild birds in the same subdistrict.

  12. Progress in Research on Pandemic Influenza H5N1 Vaccine%H5N1大流行流感疫苗的研究进展

    Institute of Scientific and Technical Information of China (English)

    张严予

    2011-01-01

    Highly pathogenic avian influenza H5N1 virus may cause serious fatal diseases and constitute a grave threat to human health. Although the current H5N1 influenza strains appear not to be transmissible from human to human, it is of major concern that mixing with human influenza strains could convert H5N1 to a strain that would spread that would spread from human to human and cause a serious pandemic. In addition, avian influenza H5N1 virus after continuous variation may break through the species barrier and spread to mammals and humans, thereby cause disease even death under the influence of various virus and host factors. This paper reviews the progress in research on pandemic influenza vaccine.%高致病性H5N1流感病毒可导致严重的致死性疾病,对人类健康造成了极大威胁.尽管目前尚未发生人与人之间传播,但该病毒一旦与人流感病毒重组,即有可能转变为可在人与人之间传播的高致死性流感病毒,从而导致新的流感大流行.此外,H5N1流感病毒经过不断变异后可突破种属屏障,从禽类传播给哺乳动物及人类,并进一步在病毒和宿主的多种因素作用下导致宿主发病乃至死亡.本文对H5N1大流行流感疫苗的研究进展作一综述.

  13. Isolasi dan Identifikasi Virus Avian Influenza Subtipe H5N1 pada Unggas di Pasar Tradisional Semarang

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    Farikhul Ulum

    2013-09-01

    Full Text Available Meningkatnya kasus infeksi virus Avian Influenza (AI subtipe H5N1 atau lebih dikenal dengan flu burung yang menyebabkan kematian pada manusia sangat dikhawatirkan dapat menular dari manusia ke manusia. Penelitian ini bertujuan untuk mendapatkan isolat virus Avian Influenza subtipe H5N1 pada unggas yang diperjualbelikan di pasar tradisional di Semarang. Sebanyak 55 sampel usap kloaka diambil dari unggas sehat dan belum divaksin di 6 pasar tradisional Kota Semarang. Inokulum ditumbuhkan pada telur ayam berembrio specific pathogen free (TAB-SPF umur sembilan hari. Kemudian telur diinkubasikan selama 4 hari. Cairan alantois dipanen dan diuji kemampuannya mengaglutinasi sel darah merah. Cairan alantois yang menunjukkan aktivitas hemaglutinasi, selanjutnya diekstraksi RNA-nya dan diidentifikasi VAI subtipe H5N1 dengan metode Reverse Transcriptase-Polymerase Chain Reaction (RT-PCR menggunakan primer spesifik H5 dan primer N1. Kemudian DNA hasil RT-PCR dianalisis dengan teknik elektroforesis. Hasil penelitian menunjukkan bahwa terdapat 4 isolat positif VAI subtipe H5N1 dengan sebaran 2 isolat dari sampel yang berasal dari pasar Mangkang, 1 isolat dari pasar Rejomulyo dan 1 isolat dari pasar Karimata. Berdasarkan hasil penelitian dan pembahasan dapat disimpulkan bahwa unggas yang diperjualbelikan di pasar tradisional di Kota Semarang ada yang terinfeksi VAI subtipe H5N1.The increasing cases of viral infection of Avian Influenza (AI H5N1 subtype or more commonly known as bird flu that causes death in humans very feared to spread from human to human. The aim of this research was to obtain isolates of Avian Influenza virus (AIV subtype H5N1 that marketable in traditional markets in Semarang. A total of 55 cloacal swab samples taken from healthy and unvaccinated fowl in the 6 traditional market in Semarang. Inoculum was grown in embryonated chicken eggs specific pathogen free (SPF TAB nine days. Then the eggs were incubated for 4 days. Allantoic fluids were

  14. Identifikasi Flu Burung H5N1 pada Unggas di Sekitar Kasus Flu Burung pada Manusia Tahun 2011 di Bekasi (AVIAN INFLUENZA H5N1 IDENTIFICATION IN AVIAN SPECIES SURROUNDING AVIAN INFLUENZA H5N1 HUMAN CASES IN BEKASI, WEST JAVA, 2011

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    Dyah Ayu Hewajuli

    2014-05-01

    Full Text Available H5N1 subtype Avian Influenza (AI virus is the causal agent  of AI disease in humans. In Indonesia,the first human AI occurred in Tangerang 2005.  Human AI in Indonesia has now spread into 12 provinces,including West Java, Jakarta, Banten, North Sumatra, East Java, Central Java, Lampung, South Sulawesi,West Sumatra, South Sumatra, Riau, and Bali. Until 2011, the total human AI cases were 182 cases  with150 deaths. This study was conducted to identify of H5N1 AI virus in birds in area surrounding a humanAI human case  in Bekasi city  in March 2011 and to investigate its role in the spread of AI to humans usingmethods of Hemaglutination Inhibition (HI , and Reverse Transcriptase-Polymerase Chain Reaction(RT-PCR. The result showed that 80% of birds in the area surrounding AI  surrounding H5N1 AI humancase in Bekasi 2011 were antibody negative  against  H5N1-AI virus. Antibody against H5N1-AI viruswith the titer less than 4 log 2 was detected in 4.4%  of birds and  with antibody titer 04 4-7 log 2 in 15%of birds. By RT-PCR, H5N1 AI virus was not detected in 47.6% of bird samples. H5 positive and N1negative  AI virus was detected in  30.2% samples.  Only 11.2% samples showed positive for H5N1 AI virus.The results suggest that H5N1-AI virus affecting birds may have a positive role in transmitting to thevirus to human in Bekasi 2011.

  15. The Behaviour of Small Investors in the Hong Kong Derivatives Markets: A Factor Analysis

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    Tai-Yuen Hon

    2012-12-01

    Full Text Available This paper investigates the behaviour of small investors in Hong Kong’s derivatives markets. The study period covers the global economic crisis of 2011- 2012, and we focus on small investors’ behaviour during and after the crisis. We attempt to identify and analyse the key factors that capture their behaviour in derivatives markets in Hong Kong. The data were collected from 524 respondents via a questionnaire survey. Exploratory factor analysis was employed to analyse the data, and some interesting findings were obtained. Our study enhances our understanding of behavioural finance in the setting of an Asian financial centre, namely Hong Kong.

  16. Analysis of hemagglutinin variance of avian influenza viru (H5N1)%禽流感病毒H5N1亚型血凝素氨基酸序列的变异分析

    Institute of Scientific and Technical Information of China (English)

    王国戗; 牛菊霞; 艾敏

    2009-01-01

    目的 研究不同来源禽流感病毒H5N1亚型血凝素(hemagglutinin,HA)氨基酸序列的变异及变异规律. 方法 以GenBank公开的禽流感病毒H5N1亚型HA氨基酸序列为材料,利用生物信息学的手段分析其同源性及氨基酸变异规律. 结果 46个禽流感病毒H5N1亚型HA氨基酸序列之间的同源性为90%~100%;同一地区来源的氨基酸之间的同源性大于异地来源的同源性;在H5N1亚型HA氨基酸序列中,天冬酰氨酸、丝氨酸、苏氨酸、精氨酸和天门冬氨酸最常发生突变. 结论 禽流感病毒H5N1亚型血凝素氨基酸序列的变异呈现出一定的规律.

  17. Characterisation of enzymatic activities of H5N1 influenza virus

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    Simson Tarigan

    2008-06-01

    Full Text Available One of the two glycoproteins projected from the surface of the influenza virus is identified as neuraminidase. This enzyme enables the virus to spread in the host, and therefore it plays vital roles in the viral pathogenicity. From the viewpoint of disease control, neuraminidase is used as the target for the development of anti-flu drugs, and for the development of diagnostic test to differentiate infected from vaccinated animals (DIVA. Since the roles of the enzyme are very important, information regarding the characteristics and the procedure to measure its activity, which is the purpose of this study, is essential. The optimum incubation time of the neuraminidase-substrate (fetuin reaction and the optimum pH of the buffer were determined. The stability of the enzyme against heating, supplementation or chelating of calcium ion, and b-propiolactone treatment were analysed. This study showed that neuraminidase from H5N1-influenza virus was, in regards to the characteristics investigated in this study, was comparable to that from Clostridium perfringens. The optimum incubation time for the viral and Clostridial neuraminidases were 60 and 30 minutes, respectively; whereas, the optimum pH for both neuraminidase was 6-7. At pH 8, both neuraminidase were inactive. Supplementation of calcium ion tended to increase activity but chelating of the cation did not have any observable effects. Treatment with 0.2% b-propiolactone for 6 hours reduced the activity, whereas heating at 60°C for 60 minutes abolished all activity. Since inactivation by b-propiolactone is partially only, neuraminidase assay could be performed safely in ordinary laboratories using b-propiolactone-treated-influenza virus, rather than the life virus. The thermolabile nature of the enzyme will complicate any attempt to purify the enzyme.

  18. Estimating the sensitivity of passive surveillance for HPAI H5N1 in Bayelsa state, Nigeria.

    Science.gov (United States)

    Ojimelukwe, Agatha E; Prakarnkamanant, Apisit; Rushton, Jonathan

    2016-07-01

    This study identified characteristics of poultry farming with a focus on practices that affect the detection of HPAI; and estimated the system sensitivity of passive surveillance for HPAI H5N1 in commercial and backyard chicken farms in Bayelsa-State, Nigeria. Field studies were carried out in Yenegoa and Ogbia local government areas in Bayelsa state. Willingness to report HPAI was highest in commercial poultry farms (13/13) than in Backyard farms (8/13). Poor means of dead bird disposal was common to both commercial and backyard farms. Administering some form of treatment to sick birds without prior consultation with a professional was higher in backyard farms (8/13) than in commercial farms (4/13). Consumption of sick birds was reported in 4/13 backyard farms and sale of dead birds was recorded in one commercial farm. The sensitivity of passive surveillance for HPAI was assessed using scenario tree modelling. A scenario tree model was developed and applied to estimate the sensitivity, i.e. the probability of detecting one or more infected chicken farms in Bayelsa state at different levels of disease prevalence. The model showed a median sensitivity of 100%, 67% and 23% for detecting HPAI by passive surveillance at a disease prevalence of 0.1%, a minimum of 10 and 3 infected poultry farms respectively. Passive surveillance system sensitivity at a design prevalence of 10 infected farms is increasable up to 86% when the disease detection in backyard chicken farms is enhanced. Copyright © 2016 Elsevier B.V. All rights reserved.

  19. Persistence of highly pathogenic avian influenza H5N1 virus defined by agro-ecological niche

    Science.gov (United States)

    Hogerwerf, Lenny; Wallace, Rob G.; Ottaviani, Daniela; Slingenbergh, Jan; Prosser, Diann; Bergmann, Luc; Gilbert, Marius

    2010-01-01

    The highly pathogenic avian influenza (HPAI) H5N1 virus has spread across Eurasia and into Africa. Its persistence in a number of countries continues to disrupt poultry production, impairs smallholder livelihoods, and raises the risk a genotype adapted to human-to-human transmission may emerge. While previous studies identified domestic duck reservoirs as a primary risk factor associated with HPAI H5N1 persistence in poultry in Southeast Asia, little is known of such factors in countries with different agro-ecological conditions, and no study has investigated the impact of such conditions on HPAI H5N1 epidemiology at the global scale. This study explores the patterns of HPAI H5N1 persistence worldwide, and for China, Indonesia, and India includes individual provinces that have reported HPAI H5N1 presence during the 2004–2008 period. Multivariate analysis of a set of 14 agricultural, environmental, climatic, and socio-economic factors demonstrates in quantitative terms that a combination of six variables discriminates the areas with human cases and persistence: agricultural population density, duck density, duck by chicken density, chicken density, the product of agricultural population density and chicken output/input ratio, and purchasing power per capita. The analysis identifies five agro-ecological clusters, or niches, representing varying degrees of disease persistence. The agro-ecological distances of all study areas to the medoid of the niche with the greatest number of human cases are used to map HPAI H5N1 risk globally. The results indicate that few countries remain where HPAI H5N1 would likely persist should it be introduced.

  20. Characterizing wild bird contact and seropositivity to highly pathogenic avian influenza A (H5N1) virus in Alaskan residents.

    Science.gov (United States)

    Reed, Carrie; Bruden, Dana; Byrd, Kathy K; Veguilla, Vic; Bruce, Michael; Hurlburt, Debby; Wang, David; Holiday, Crystal; Hancock, Kathy; Ortiz, Justin R; Klejka, Joe; Katz, Jacqueline M; Uyeki, Timothy M

    2014-09-01

    Highly pathogenic avian influenza A (HPAI) H5N1 viruses have infected poultry and wild birds on three continents with more than 600 reported human cases (59% mortality) since 2003. Wild aquatic birds are the natural reservoir for avian influenza A viruses, and migratory birds have been documented with HPAI H5N1 virus infection. Since 2005, clade 2.2 HPAI H5N1 viruses have spread from Asia to many countries. We conducted a cross-sectional seroepidemiological survey in Anchorage and western Alaska to identify possible behaviors associated with migratory bird exposure and measure seropositivity to HPAI H5N1. We enrolled rural subsistence bird hunters and their families, urban sport hunters, wildlife biologists, and a comparison group without bird contact. We interviewed participants regarding their exposures to wild birds and collected blood to perform serologic testing for antibodies against a clade 2.2 HPAI H5N1 virus strain. Hunters and wildlife biologists reported exposures to wild migratory birds that may confer risk of infection with avian influenza A viruses, although none of the 916 participants had evidence of seropositivity to HPAI H5N1. We characterized wild bird contact among Alaskans and behaviors that may influence risk of infection with avian influenza A viruses. Such knowledge can inform surveillance and risk communication surrounding HPAI H5N1 and other influenza viruses in a population with exposure to wild birds at a crossroads of intercontinental migratory flyways. © 2014 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd.

  1. A biography of arsenic and medicine in Hong Kong and China.

    Science.gov (United States)

    Au, W Y

    2011-12-01

    Arsenic trioxide has been used in traditional Chinese medicine for over 5000 years, but lost its appeal due to its toxicity. It was rediscovered in western medicine and enjoyed a renaissance from 1830 to 1930, as the first effective chemotherapy against syphilis, parasites and leukaemia. These years were also a time of political turmoil in China. The Nanking treaty (29 August 1842) turned Hong Kong into a colony, while the Xinhai Revolution (10 October 1911) gave birth to a republic of China. Arsenic returned to China and Hong Kong with the establishment of the first medical schools from 1887 to 1920. Until 1950, oral arsenic trioxide was the standard anti-leukaemic treatment in Queen Mary Hospital. The advent of alkylating chemotherapeutic agents replaced arsenic trioxide in Hong Kong and around the world. In the 1970s, however, the specific activity of arsenic trioxide against acute promyelocytic leukaemia was re-discovered during the Cultural Revolution in Harbin, China. In 1997, Hong Kong was returned to China. In the same year, arsenic trioxide returned to the world stage. Intravenous arsenic trioxide became the worldwide standard therapy for relapsed acute promyelocytic leukaemia. Oral administration of arsenic trioxide was revived in Hong Kong in 2000. This resulted in the first locally produced, registered, patented prescription drug in Hong Kong. Pending imminent manufacture, this product is poised to revolutionise acute promyelocytic leukaemia care and may hold the key to saving the lives of acute promyelocytic leukaemia patients worldwide. The remarkable journey of arsenic in the setting of medical history of China and Hong Kong is reviewed.

  2. 感染人类的禽流感病毒A(H5N1)研究进展%Update on avian influenza A(H5N1)virus infection in humans

    Institute of Scientific and Technical Information of China (English)

    钟晓琴; 王关嵩

    2009-01-01

    @@ 禽流感病毒A(H5N1)[avian influenza(H5N1)viruses]之前一直存在于鸟类,但却能导致人类疾病,并且具有高致死性和广泛流行的威胁.本文在综合了第二届世界卫生组织(World Health Organization,WHO)感染人类禽流感病毒A(H5N1)临床诊断咨询会议公布的研究信息[2]基础上,对2005年的报告[1]进行了更新.

  3. The Threat of H5N1 Avian Influenza and Global Preparedness%H5N1禽流感的威胁与全球应对

    Institute of Scientific and Technical Information of China (English)

    田德桥; 郑涛

    2007-01-01

    当前H5N1禽流感在迁徙禽类、家禽中的暴发,以及越来越多的人感染病例的发生,使流感全球大流行的可能性持续存在.简要综述了H5N1禽流感在鸟类和其他动物中的暴发情况,H5N1禽流感的人感染病例,以及全球禽流感应对计划及疫苗、药物、病原体基础研究的进展.

  4. Regular Source of Care for the Elderly: A Cross-National Comparative Study of Hong Kong With 11 Developed Countries.

    Science.gov (United States)

    Wong, Samuel Yeung-Shan; Zou, Dan; Chung, Roger Y; Sit, Regina W; Zhang, Dexing; Chan, Dicken; Yeoh, Eng Kiong; Woo, Jean W

    2017-09-01

    This study aimed to give an international perspective of health service gaps for caring for elderly individuals and explore the role of primary care for caring for elderly individuals with chronic conditions in Hong Kong. Cross-sectional, telephone survey. Hong Kong. A sample of 1000 Chinese participants in Hong Kong aged 60 or older. Questionnaire extracted from the Commonwealth Fund 2014 International Health Policy Survey of Older Adults. Similar to the 11 countries, more than half (about 65%) of Hong Kong respondents suffered from chronic conditions, whereas approximately one-third of them had at least 2 chronic conditions. US respondents had highest rate of having chronic conditions. Only 65% of Hong Kong respondents reported having a regular source of care and a higher proportion of elderly reported having poor self-rated health when compared with overseas counterparts. However, the proportion of elderly individuals who could access same-day or next-day medical care was higher compared with findings of other countries. Both Hong Kong and US respondents were more likely to report cost-related problems when accessing care. Waiting time for specialists in Hong Kong was much longer and coordination between regular doctors was poorer than in all other countries. Although half of Hong Kong respondents had a management plan for chronic conditions, a smaller proportion of them considered it helpful. Hong Kong has the lowest rate of regular source of care when compared with 11 developed countries, although people in Hong Kong were more likely to be able to access same-day or next-day medical care. To cope with increasing needs of chronic disease care, there may be a need to further develop the provision of regular source of care for elderly individuals, including the development of quality primary care in Hong Kong. Copyright © 2017 AMDA – The Society for Post-Acute and Long-Term Care Medicine. Published by Elsevier Inc. All rights reserved.

  5. Dietary exposure of the Hong Kong adult population to polybrominated diphenyl ethers (PBDEs): results of the first Hong Kong Total Diet Study.

    Science.gov (United States)

    Chen, M Y Y; Wong, W W K; Choi, K K; Yip, Y C; Ho, Y Y; Xiao, Y

    2013-01-01

    Polybrominated diphenyl ethers (PBDEs) are a group of industrial chemicals that are persistent and can bioaccumulate. In the first Hong Kong Total Diet Study, the dietary exposure of Hong Kong adults to PBDEs was estimated to assess the associated health risks. Food samples, which represented the Hong Kong people's diet, were collected and prepared in table-ready form for analysis. Concentrations of PBDEs were determined in 142 composite samples. The dietary exposures were estimated by combining the analytical results with the local food consumption data of the adults. The mean and 95th percentile of dietary PBDEs exposures of the Hong Kong people were 1.34 and 2.90 ng kg(-1) body weight day(-1), respectively. The main dietary source of PBDEs was "fish and seafood and their products", which contributed 27.3% of the total exposure, followed by "meat, poultry and game and their products" (20.7%), "cereals and their products" (15.9%), and "fats and oils" (15.9%). The large margins of exposure (MOE) (>2.5) calculated following the European Food Safety Authority (EFSA) approach for four important congeners, BDE-47, BDE-99, BDE-153 and BDE-209, indicate that the estimated dietary exposures are unlikely to be a significant health concern.

  6. Knowledge, attitudes, practices and emotional reactions among residents of avian influenza (H5N1 hit communities in Vietnam.

    Directory of Open Access Journals (Sweden)

    Toshie Manabe

    Full Text Available BACKGROUND: Awareness of individuals' knowledge and predicting their behavior and emotional reactions is crucial when evaluating clinical preparedness for influenza pandemics with a highly pathogenic virus. Knowledge, attitude, and practice (KAP relating to avian influenza (H5N1 virus infection among residents in communities where H5N1 patients occurred in Vietnam has not been reported. METHODS AND PRINCIPAL FINDINGS: Face-to-face interviews including KAP survey were conducted in Bac Kan province, located in the northeast mountainous region of Vietnam. Participants were residents who lived in a community where H5N1 cases have ever been reported (event group, n = 322 or one where cases have not been reported (non-event group, n = 221. Data on emotional reactions of participants and healthcare-seeking behavior after the event in neighboring areas were collected as well as information on demographics and environmental measures, information sources, and KAP regarding H5N1. These data were compared between two groups. Higher environmental risk of H5N1 and improper poultry-handling behaviors were identified in the event group. At the time of the event, over 50% of the event group sought healthcare for flu-like symptoms or because they were scared. Awareness of the event influenced KAP scores. Healthcare-seeking behavior and attention to H5N1 poultry outbreaks diminished in the event group as time passed after the outbreak compared with the non-event group. Factors that motivated participants to seek healthcare sooner were knowledge of early access to healthcare and the risk of eating sick/dead poultry, and perception of the threat of H5N1. CONCLUSIONS: Awareness of H5N1 patients in neighboring areas can provoke panic in residents and influence their healthcare-seeking behavior. Periodic education to share experiences on the occurrence of H5N1 patients and provide accurate information may help prevent panic and infection and reduce mortality

  7. Risk Distribution of Human Infections with Avian Influenza H7N9 and H5N1 virus in China.

    Science.gov (United States)

    Li, Xin-Lou; Yang, Yang; Sun, Ye; Chen, Wan-Jun; Sun, Ruo-Xi; Liu, Kun; Ma, Mai-Juan; Liang, Song; Yao, Hong-Wu; Gray, Gregory C; Fang, Li-Qun; Cao, Wu-Chun

    2015-12-22

    It has been documented that the epidemiological characteristics of human infections with H7N9 differ significantly between H5N1. However, potential factors that may explain the different spatial distributions remain unexplored. We use boosted regression tree (BRT) models to explore the association of agro-ecological, environmental and meteorological variables with the occurrence of human cases of H7N9 and H5N1, and map the probabilities of occurrence of human cases. Live poultry markets, density of human, coverage of built-up land, relative humidity and precipitation were significant predictors for both. In addition, density of poultry, coverage of shrub and temperature played important roles for human H7N9 infection, whereas human H5N1 infection was associated with coverage of forest and water body. Based on the risks and distribution of ecological characteristics which may facilitate the circulation of the two viruses, we found Yangtze River Delta and Pearl River Delta, along with a few spots on the southeast coastline, to be the high risk areas for H7N9 and H5N1. Additional, H5N1 risk spots were identified in eastern Sichuan and southern Yunnan Provinces. Surveillance of the two viruses needs to be enhanced in these high risk areas to reduce the risk of future epidemics of avian influenza in China.

  8. Antigenicity and transmissibility of a novel clade 2.3.2.1 avian influenza H5N1 virus.

    Science.gov (United States)

    Xu, Lili; Bao, Linlin; Yuan, Jing; Li, Fengdi; Lv, Qi; Deng, Wei; Xu, Yanfeng; Yao, Yanfeng; Yu, Pin; Chen, Honglin; Yuen, Kwok-Yung; Qin, Chuan

    2013-12-01

    A genetic variant of the H5N1 influenza virus, termed subclade 2.3.2.1, was first identified in Bulgaria in 2010 and has subsequently been found in Vietnam and Laos. Several cases of human infections with this virus have been identified. Thus, it is important to understand the antigenic properties and transmissibility of this variant. Our results showed that, although it is phylogenetically closely related to other previously characterized clade 2.3 viruses, this novel 2.3.2.1 variant exhibited distinct antigenic properties and showed little cross-reactivity to sera raised against other H5N1 viruses. Like other H5N1 viruses, this variant bound preferentially to avian-type receptors, but contained substitutions at positions 190 and 158 of the haemagglutinin (HA) protein that have been postulated to facilitate HA binding to human-type receptors and to enhance viral transmissibility among mammals, respectively. However, this virus did not appear to have acquired the capacity for airborne transmission between ferrets. These findings highlight the challenges in selecting vaccine candidates for H5N1 influenza because these viruses continue to evolve rapidly in the field. It is important to note that some variants have obtained mutations that may gain transmissibility between model animals, and close surveillance of H5N1 viruses in poultry is warranted.

  9. 高致病性H5N1流感病毒所致人类感染

    Institute of Scientific and Technical Information of China (English)

    Andrea Gambotto; Simon M Barratt-Boyes; Menno D de Jong; Gabriele Neumann; Yoshihiro Kawaoka; 林磊(译); 秦成峰(译)

    2009-01-01

    自2003年以来,H5N1高致病性流感病毒在全球无情肆虐,引起家禽大面积死亡,给养殖业主造成了巨大损失。至今已报告的人感染H5N1流感病例达300多例,病死率高达60%。由于H5N1流感病毒具有高致病性,并且可由禽类传染至人,人们担心会出现一场新的人类流感大流行,就像1918年在西班牙发生的著名的H1N1型大流感一样。鉴于H5N1流感在多方面的研究进展都很迅速,本专题中,我们将着重讨论临床医生和研究人员所感兴趣的课题的最新进展。这里,我们将总结人类感染H5N1流感病毒的临床症状、

  10. The first specific detection of a highly pathogenic avian influenza virus (H5N1) in Ivory Coast.

    Science.gov (United States)

    Couacy-Hymann, E; Danho, T; Keita, D; Bodjo, S C; Kouakou, C; Koffi, Y M; Beudje, F; Tripodi, A; de Benedictis, P; Cattoli, G

    2009-02-01

    The Virology Laboratory of the Central Laboratory of Animal Diseases in Ivory Coast at Bingerville received samples of wild and domestic avian species between February and December 2006. An RT-PCR technique was used to test for avian influenza (AI) and highly pathogenic AI subtype viruses. Among 2125 samples, 16 were type A positive; of which, 12 were later confirmed to be H5N1. Fifteen of these 16 type A positive samples were inoculated into the chorioallantoic cavity of 11-day-old embryonated hens' eggs for virus isolation. Eight produced virus with hemagglutination titres from 1/64 to 1/512. The 4/16 M-RT-PCR positive samples, which were H5N1 negative, were shown to be H7 subtype negative. The diagnostic efficiency of the laboratory for the surveillance of H5N1 in Ivory Coast was demonstrated. The positive cases of H5N1 were from a sparrowhawk (Accipter nisus); live market poultry and in free-range poultry, where the mortality rate was approximately 20% (2/10) and 96.7% (29/30) respectively. Currently, investigations into intensive poultry farms have proved negative for H5N1. No human cases have been reported this time.

  11. Ecology and geography of avian influenza (HPAI H5N1 transmission in the Middle East and northeastern Africa

    Directory of Open Access Journals (Sweden)

    Peterson A Townsend

    2009-07-01

    Full Text Available Abstract Background The emerging highly pathogenic avian influenza strain H5N1 ("HPAI-H5N1" has spread broadly in the past decade, and is now the focus of considerable concern. We tested the hypothesis that spatial distributions of HPAI-H5N1 cases are related consistently and predictably to coarse-scale environmental features in the Middle East and northeastern Africa. We used ecological niche models to relate virus occurrences to 8 km resolution digital data layers summarizing parameters of monthly surface reflectance and landform. Predictive challenges included a variety of spatial stratification schemes in which models were challenged to predict case distributions in broadly unsampled areas. Results In almost all tests, HPAI-H5N1 cases were indeed occurring under predictable sets of environmental conditions, generally predicted absent from areas with low NDVI values and minimal seasonal variation, and present in areas with a broad range of and appreciable seasonal variation in NDVI values. Although we documented significant predictive ability of our models, even between our study region and West Africa, case occurrences in the Arabian Peninsula appear to follow a distinct environmental regime. Conclusion Overall, we documented a variable environmental "fingerprint" for areas suitable for HPAI-H5N1 transmission.

  12. Multiplexed, rapid detection of H5N1 using a PCR-free nanoparticle-based genomic microarray assay

    Directory of Open Access Journals (Sweden)

    Ragupathy Viswanath

    2010-10-01

    Full Text Available Abstract Background For more than a decade there has been increasing interest in the use of nanotechnology and microarray platforms for diagnostic applications. In this report, we describe a rapid and simple gold nanoparticle (NP-based genomic microarray assay for specific identification of avian influenza virus H5N1 and its discrimination from other major influenza A virus strains (H1N1, H3N2. Results Capture and intermediate oligonucleotides were designed based on the consensus sequences of the matrix (M gene of H1N1, H3N2 and H5N1 viruses, and sequences specific for the hemaglutinin (HA and neuraminidase (NA genes of the H5N1 virus. Viral RNA was detected within 2.5 hours using capture-target-intermediate oligonucleotide hybridization and gold NP-mediated silver staining in the absence of RNA fragmentation, target amplification, and enzymatic reactions. The lower limit of detection (LOD of the assay was less than 100 fM for purified PCR fragments and 103 TCID50 units for H5N1 viral RNA. Conclusions The NP-based microarray assay was able to detect and distinguish H5N1 sequences from those of major influenza A viruses (H1N1, H3N2. The new method described here may be useful for simultaneous detection and subtyping of major influenza A viruses.

  13. PB2 Segment Promotes High-pathogenicity Of H5N1 Avian Influenza Viruses In Mice

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    Hailiang eSun

    2015-02-01

    Full Text Available H5N1 influenza viruses with high lethality are a continuing threat to humans and poultry. Recently, H5N1 high-pathogenicity avian influenza virus (HPAIV has been shown to transmit through aerosols between ferrets in lab experiments by acquiring some mutation. This is another deeply aggravated threat of H5N1 HPAIV to humans. To further explore the molecular determinant of H5N1 HPAIV virulence in a mammalian model, we compared the virulence of A/Duck/Guangdong/212/2004 (DK212 and A/Quail/Guangdong/90/2004 (QL90. Though they were genetically similar, they had different pathogenicity in mice, as well as their 16 reassortants. The results indicated that a swap of the PB2 gene could dramatically decrease the virulence of rgDK212 in mice (1896-fold but increase the virulence of rgQL90 in mice (60-fold. Furthermore, the polymerase activity assays showed that swapping PB2 genes between these two viruses significantly changed the activity of polymerase complexes in 293T cells. The mutation Ser715Asn in PB2 sharply attenuated the virulence of rgDK212 in mice (2710-fold. PB2 segment promotes high-pathogenicity of H5N1 avian influenza viruses in mice and 715 Ser in PB2 plays an important role in determing high virulence of DK212 in mice.

  14. Plus Ca Change, Plus C'Est La Meme Chose: Attitudes towards English Language Learning in Hong Kong--Frederick Stewart's Evidence.

    Science.gov (United States)

    Bickley, Gillian

    1990-01-01

    Suggests that the attitudes of the people of Hong Kong toward learning English, during both an earlier period and at present, are similar and deeply entrenched. The increasing emigration of Hong Kong people, mainly to Anglophone countries, makes an international understanding of the attitude of Hong Kong people toward learning English very…

  15. Plus Ca Change, Plus C'Est La Meme Chose: Attitudes towards English Language Learning in Hong Kong--Frederick Stewart's Evidence.

    Science.gov (United States)

    Bickley, Gillian

    1990-01-01

    Suggests that the attitudes of the people of Hong Kong toward learning English, during both an earlier period and at present, are similar and deeply entrenched. The increasing emigration of Hong Kong people, mainly to Anglophone countries, makes an international understanding of the attitude of Hong Kong people toward learning English very…

  16. The Currency of Historicity in Hong Kong: Deconstructing Nostalgia through Soy Milk

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    Catherine S. Chan

    2015-01-01

    Full Text Available In the 1980s, as the end of the millennium approached, the production of nostalgia exploded all around the world. For Hong Kong, nostalgia became a reminder of the golden age that had transformed the city into one of the “Four Asian Tigers” in the decades following the end of the Second World War. While yearning for the better days of the past, Hong Kong coincidentally experienced destabilisation. As the rest of the world, especially the “baby boomers,” mourned the end of a productive era, Hong Kong locals were disturbed by the affirmation of the handover to China in 1997. In the context of these events, a creative rush to nostalgia in cultural manufacturing swept across the city. In the hope of highlighting the uniqueness of nostalgic production in Hong Kong, this study analyses two sets of TV commercials produced by local beverage company Vitasoy. Through the deconstruction of selected historical events, Vitasoy successfully reinvented its brand and, in contrast to general criticism of the concept, generated a positive connotation for nostalgia on the path towards Hong Kong’s search for an identity.

  17. Managing the Accessibility on Mass Public Transit: the Case of Hong Kong

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    Siman Tang

    2008-11-01

    Full Text Available Public transit services (PTS improve mobility and accessibility, and reduce car dependence. It is ideal if PTS are financially sustainable, with affordable fares and expedient quality. The success of PTS on accessibility improvement can be reflected by their level of patronage: do travelers choose to use them in lieu of their private cars? PTS in Hong Kong are renowned for their quality and profitability, superbly addressing the accessibility need for the city; they carry over 90% of the 11 million daily trips. A comparison of the per capita train-car and bus-vehicle kilometer run of PTS in Hong Kong with those in London and Singapore, however, suggests that it is not purely the supply that affects the use or accessibility of PTS in Hong Kong. By tracing and analyzing the development of PTS in Hong Kong over the past two decades, we found evidence that the high level of accessibility on mass public transit in the territory can be attributed to the land use policy of developing compact, high-density township, accompanying transport policies of granting high priority to the development of mass transit facilities and providing ways to ensure the financial viability of privately operated PTS, especially the innovative approach of integrating the development of public transport facility and property so as to exploit their synergy. In this paper, we study and highlight elements that contribute to the development of high accessibility on mass public transit in Hong Kong.

  18. Examining Factors Affecting Science Achievement of Hong Kong in PISA 2006 Using Hierarchical Linear Modeling

    Science.gov (United States)

    Lam, Terence Yuk Ping; Lau, Kwok Chi

    2014-10-01

    This study uses hierarchical linear modeling to examine the influence of a range of factors on the science performances of Hong Kong students in PISA 2006. Hong Kong has been consistently ranked highly in international science assessments, such as Programme for International Student Assessment and Trends in International Mathematics and Science Study; therefore, an exploration of the factors that affect science performances of Hong Kong students can give a lens to examine how science education can be improved in Hong Kong and other countries. The analyses reveal that student backgrounds as male, at higher grade levels, and born in mainland (when in the same grade) are associated with better science performance. Among the attitudinal factors, enjoyment of science and self-efficacy in science play important roles in scientific achievements. Most of the parental factors, on the other hand, are not having significant impacts on achievement after student attitudes are taken into account, with only parents' value of science having a small effect. School student intake is found to be a strong predictor of school average achievement, as well as a major mediator of the effects of school enrollment size and school socio-economic status. The findings differ from recently reported results, which suggested that school enrollment size was associated with achievement. This study also points out the problems of the use of science instruction time as a school-level variable to explain science achievement in Hong Kong.

  19. Why is Design-Build Commonly Used in the Public Sector? An Illustration from Hong Kong

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    Edmond Lam

    2012-11-01

    Full Text Available The Design and Build (D&B procurement method is one of the systems advocated to overcome inadequacies with the traditional procurement method. In recent years, this innovative procurement method has been put to practice in Hong Kong where a vast amount of infrastructure works is taking place. This paper aims to illustrate the applicability of design-build in the Hong Kong setting.As most D&B projects are undertaken by the public sector of Hong Kong, the main features of a public sector project and reasons for its wider use on D&B are fully examined in the paper. To further explore the benefits of D&B in actual practice, structured interviews have been conducted with clients, contractors and consultants running D&B projects in Hong Kong. Summary of major problems of running D&B projects from the previous study by the authors is also outlined. With the increasing use of D&B in the public sector of Hong Kong and worldwide, more research can be undertaken on the quantitative comparison of the traditional mode of procurement and how to carry out a D&B project successfully so as to develop a knowledge base for the D&B procurement method.

  20. Compare the difference of architecture design in Hong Kong and Penang – Exterior wall

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    Liu Wen Tao

    2015-12-01

    Full Text Available This research focuses on the exterior wall of architecture design of Hong Kong and Penang, it also analyzes how light pollution affects human life. As we know, Hong Kong prefers to use steel to build skyscrapers and middle or high rise buildings. However, Penang prefers to use concrete to do the construction. So, there are some advantages and disadvantages between the glass curtain wall and concrete wall in Hong Kong and Penang. The researcher used 400 samples to determine effect of the glass curtain wall and concrete wall on human life in Hong Kong and Penang separately. The result is light pollution created by glass curtain wall in Hong Kong is a serious problem to residents’ life. The glass curtain wall seriously glaze people’s eyes who drive or walk on the street. Thus, many car accidents were caused by this problem. The concrete wall is more often contaminated by fungus and difficult to clean. But, concrete wall is more natural and green for humans. Therefore, from the sustainable aspect that concrete is more healthy for humans, the previous researchers suggest that if the exterior wall is a mixture of both glass curtain and concrete it will not cause light pollution and will be easily involved in the natural environment.

  1. Is Hong Kong experiencing normalization of adolescent drug use? Some reflections on the normalization thesis.

    Science.gov (United States)

    Cheung, Nicole W T; Cheung, Yuet W

    2006-01-01

    The upsurge of consumption of party drugs among adolescents in recent years in Hong Kong has been part of the global trend of adolescent recreational use of drugs at rave parties, discos and similar party settings. Scholars in Western societies have recently proposed the thesis of "normalization of adolescent drug use" to describe such a trend. The normalization thesis points at three major aspects of the normalization phenomenon, namely, a rapid increase of the prevalence of drug use in young people, the widespread popularity of recreational drug use that is closely linked with the recent arrival of dance club culture, and a receptive attitude towards drug use as a normal part of leisure. This article aims to examine whether the normalization thesis can be applied to analyze the situation of adolescent drug use in Hong Kong. Data are drawn from official statistics and a recent survey conducted in 2002-2004 of drug use of Hong Kong marginal youths (N = 504). The case of Hong Kong only partially supports the thesis. Our findings show that the normalization of drug use among young people has occurred in Hong Kong, but the extent of normalization is smaller than those in Western societies like the United Kingdom. They also suggest that a recognition of possible cultural differences may be complementary to the normalization thesis. Limitations of the study are also noted.

  2. Allergy in Hong Kong: an unmet need in service provision and training.

    Science.gov (United States)

    Chan, Y T; Ho, H K; Lai, Christopher K W; Lau, C S; Lau, Y L; Lee, T H; Leung, T F; Wong, Gary W K; Wu, Y Y

    2015-02-01

    Many children in Hong Kong have allergic diseases and epidemiological data support a rising trend. Only a minority of children will grow out of their allergic diseases, so the heavy clinical burden will persist into adulthood. In an otherwise high-quality health care landscape in Hong Kong, allergy services and training are a seriously unmet need. There is one allergy specialist for 1.5 million people, which is low not only compared with international figures, but also compared with most other specialties in Hong Kong. The ratio of paediatric and adult allergists per person is around 1:460 000 and 1:2.8 million, respectively, so there is a severe lack of adult allergists, while the paediatric allergists only spend a fraction of their time working with allergy. There are no allergists and no dedicated allergy services in adult medicine in public hospitals. Laboratory support for allergy and immunology is not comprehensive and there is only one laboratory in the public sector supervised by accredited immunologists. These findings clearly have profound implications for the profession and the community of Hong Kong and should be remedied without delay. Key recommendations are proposed that could help bridge the gaps, including the creation of two new pilot allergy centres in a hub-and-spoke model in the public sector. This could require recruitment of specialists from overseas to develop the process if there are no accredited allergy specialists in Hong Kong who could fulfil this role.

  3. Doubling over ten years of central obesity in Hong Kong Chinese working men

    Institute of Scientific and Technical Information of China (English)

    KO Gary Tin-choi; CHAN Juliana; CHAN Amy; WONG Patrick; HUI Stanley; CHOW Ferrie; TONG Spencer; CHAN Cecilia

    2007-01-01

    Background Obesity is now an epidemic in most parts of the world. In this cross sectional study, we report the most recent data on obesity in Hong Kong Chinese working population and compare the changes over 10 years.Methods Between July 2000 and March 2002, 5882 adult subjects from the working class in Hong Kong were recruited (2716 men (46.2%) and 3166 women (53.8%)). They were randomly selected using computer generated codes according to the distribution of occupational groups. Results of this study were compared with the data collected from a prevalence survey for cardiovascular risk factors in a Hong Kong Chinese working population conducted in 1990 (1513 subjects, 910 men (60.1%) and 603 women (39.9%)).Results Standardized percentages of overweight, obesity, and central obesity, in Hong Kong Chinese working population were 59.7%, 35.0%, 26.7% in men and 32.0%, 21.7%, 26.7% in women. Compared to the data collected in 1990, the percentage of obesity increased by 5% in men and reduced by 6% in women. The percentage of central obesity doubled in men (from 12.2% to 26.7%) but remained stable in women.Conclusions There is a doubling of the percentage of central obesity in Hong Kong Chinese working men over previous decade. Education and proper lifestyle modification program to tackle this social health issue are urgently indicated.

  4. Competitive Potential in Clothing Exports for Hong Kong and the Interior of China

    Institute of Scientific and Technical Information of China (English)

    区健勋

    2001-01-01

    Hong Kong and the Interior of China are leading clothing exporters in the world. Together they accounted for nearly 29 percent of the global clothing exports in 1999.The paper is basically divided into two parts. Firstly, it discusses that high world market share is an indicator of competitiveness for the product. From United Nations statistics, it was identified that Hong Kong and the Interior of China were competitive in certain discrete clothing items and a trend was apparent in the production shift of labour intensive clothing items from Hong Kong to the Mainland as witnessed from 1987-1993. With the revised statistical classification system in clothing items released by United Nations, second part of the paper further investigates the broad clothing categories of knitted and woven garments from 1987-1998. It was discovered that Hong Kong was traditionally more competitive in knitted garments while the Interior of China possessed advantages in the manufacture of woven items. Taking the labour cost advantage of the Interior of China and the marketing strengths of Hong Kong, their co-operation for clothing production is considered complementary to each other and able to foster synergistic effects.

  5. Multivalent HA DNA vaccination protects against highly pathogenic H5N1 avian influenza infection in chickens and mice.

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    Srinivas Rao

    Full Text Available BACKGROUND: Sustained outbreaks of highly pathogenic avian influenza (HPAI H5N1 in avian species increase the risk of reassortment and adaptation to humans. The ability to contain its spread in chickens would reduce this threat and help maintain the capacity for egg-based vaccine production. While vaccines offer the potential to control avian disease, a major concern of current vaccines is their potency and inability to protect against evolving avian influenza viruses. METHODOLOGY / PRINCIPAL FINDINGS: The ability of DNA vaccines encoding hemagglutinin (HA proteins from different HPAI H5N1 serotypes was evaluated for its ability to elicit neutralizing antibodies and to protect against homologous and heterologous HPAI H5N1 strain challenge in mice and chickens after DNA immunization by needle and syringe or with a pressure injection device. These vaccines elicited antibodies that neutralized multiple strains of HPAI H5N1 when given in combinations containing up to 10 HAs. The response was dose-dependent, and breadth was determined by the choice of the influenza virus HA in the vaccine. Monovalent and trivalent HA vaccines were tested first in mice and conferred protection against lethal H5N1 A/Vietnam/1203/2004 challenge 68 weeks after vaccination. In chickens, protection was observed against heterologous strains of HPAI H5N1 after vaccination with a trivalent H5 serotype DNA vaccine with doses as low as 5 microg DNA given twice either by intramuscular needle injection or with a needle-free device. CONCLUSIONS/SIGNIFICANCE: DNA vaccines offer a generic approach to influenza virus immunization applicable to multiple animal species. In addition, the ability to substitute plasmids encoding different strains enables rapid adaptation of the vaccine to newly evolving field isolates.

  6. Molecular evolution of H5N1 highly pathogenic avian influenza viruses in Bangladesh between 2007 and 2012.

    Science.gov (United States)

    Haque, M E; Giasuddin, M; Chowdhury, E H; Islam, M R

    2014-01-01

    In Bangladesh, highly pathogenic avian influenza (HPAI) virus subtype H5N1 was first detected in February 2007. Since then the virus has become entrenched in poultry farms of Bangladesh. There have so far been seven human cases of H5N1 HPAI infection in Bangladesh with one death. The objective of the present study was to investigate the molecular evolution of H5N1 HPAI viruses during 2007 to 2012. Partial or complete nucleotide sequences of all eight gene segments of two chicken isolates, five gene segments of a duck isolate and the haemagglutinin gene segment of 18 isolates from Bangladesh were established in the present study and subjected to molecular analysis. In addition, full-length sequences of different gene segments of other Bangladeshi H5N1 isolates available in GenBank were included in the analysis. The analysis revealed that the first introduction of clade 2.2 virus in Bangladesh in 2007 was followed by the introduction of clade 2.3.2.1 and 2.3.4 viruses in 2011. However, only clade 2.3.2.1 viruses could be isolated in 2012, indicating progressive replacement of clade 2.2 and 2.3.4 viruses. There has been an event of segment re-assortment between H5N1 and H9N2 viruses in Bangladesh, where H5N1 virus acquired the PB1 gene from a H9N2 virus. Point mutations have accumulated in Bangladeshi isolates over the last 5 years with potential modification of receptor binding site and antigenic sites. Extensive and continuous molecular epidemiological studies are necessary to monitor the evolution of circulating avian influenza viruses in Bangladesh.

  7. PHYLOGENETIC AND ANTIGENIC STRUCTURE OF AVIAN INFLUENZA VIRUS OF H5N1 SUBTYPE ISOLATED FROM WATERFOWLS

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    R Susanti

    2008-09-01

    Full Text Available A study was carried (1 to analyze the phylogenetic relationship of fragment hemaglutinin (HA geneof avian influenza viruses (AIV subtype H5N1 isolated from apparently healthy backyard waterfowls inWest Java with representative of animal and human isolates from Indonesia and some countries in Asia;(2 to find out cross-reactivity of those viruses with a standard Indonesian strain. Nucleotide sequences ofHA gene of AIV H5N1 from backyard waterfowls along with other H5N1 isolates of Indonesian and Asianorigin were aligned using with ClustalW of MEGA 3.1 program. Estimation of genetic distance and theconstruction phylogenetic tree were conducted by Neighbor Joining method and calculation of distancematrix using Kimura 2-parameter. Antigenic analysis was conducted using hemagglutination inhibition(HI test. Result of phylogenetic analysis indicated that all viruses from backyard waterfowls form threedistinct sublineages. One lineage was located in Indonesia cluster and two lineages in Asia cluster. In thephylogenetic analysis, it was concluded that multiple introductions of AIV H5N1 to Indonesia have occurred.Six AI H5N1 viruses from backyard waterfowls (IPB1-RS to IPB6-RS appeared to be different ancestorsthose isolated previously in Indonesia. Cross-antigenic analysis showed that nine viruses isolates used inthis study were antigenically different to Legok 2003 chicken strain of AIV H5N1. The HI titer of anti-Legok 2003 antibody with all newly isolated viruses is up to 6 log lower then the HI titer using homologstrain.

  8. An Evaluation of the Collaborative Mode of Professional Development for Teachers in Special Schools in Hong Kong

    Science.gov (United States)

    Ho, Fuk-chuen; Arthur-Kelly, Michael

    2013-01-01

    This study, by Fuk-chuen Ho of the Hong Kong Institute of Education and Michael Arthur-Kelly of the University of Newcastle, aimed to evaluate the effectiveness of a professional development programme for in-service teachers in Hong Kong special schools. The goal of the programme was to deliver a field-based mode of training for teachers in…

  9. Influenza Vaccination Uptake and Associated Factors among Elderly Population in Hong Kong: The Application of the Health Belief Model

    Science.gov (United States)

    Mo, P. K. H.; Lau, J. T. F.

    2015-01-01

    The impact of influenza on elderly can be severe and fatal. Influenza vaccination (IV) has been shown to be effective in reducing influenza-related complications, but the IV uptake among elderly in Hong Kong remains low. This study investigated the prevalence and factors associated with IV among Chinese elderly in Hong Kong using the Health Belief…

  10. Children's Views on Child Abuse and Neglect: Findings from an Exploratory Study with Chinese Children in Hong Kong

    Science.gov (United States)

    Chan, Yuk-chung; Lam, Gladys L. T.; Shae, Wan-Chaw

    2011-01-01

    Objectives: This research study explored children's views on issues about child abuse in Hong Kong and examined their implications on child protection work and research in Chinese societies. Method: Six primary schools were recruited from different districts of Hong Kong. Five vignettes of child maltreatment in the form of flash movies were…

  11. Application of Sociology of Education on Early Childhood Curriculum and Pedagogic Practices in Hong Kong: Insight from David Riesman

    Science.gov (United States)

    Lau, Grace; Ho, Kwok Keung

    2016-01-01

    This paper will present multiple themes that are intermingled with one another, aiming to bring an overview of sociology of education and its application in the Hong Kong situation. One of the themes concerns how sociology of education has intertwined with the socio-political aspect of Hong Kong before and after year 1997 resulting in different…

  12. Implementation of Geographic Information System (GIS) in Secondary Geography Curriculum in Hong Kong: Current Situations and Future Directions

    Science.gov (United States)

    Lam, Chi-Chung; Lai, Edith; Wong, Janice

    2009-01-01

    Using geographic information system (GIS) in teaching and learning geography is an important direction in the secondary geography curriculum in Hong Kong. In the present study, interviews were conducted individually with 28 geography teachers from different secondary schools in Hong Kong, with a view to finding their views on the inclusion of GIS…

  13. Children's Views on Child Abuse and Neglect: Findings from an Exploratory Study with Chinese Children in Hong Kong

    Science.gov (United States)

    Chan, Yuk-chung; Lam, Gladys L. T.; Shae, Wan-Chaw

    2011-01-01

    Objectives: This research study explored children's views on issues about child abuse in Hong Kong and examined their implications on child protection work and research in Chinese societies. Method: Six primary schools were recruited from different districts of Hong Kong. Five vignettes of child maltreatment in the form of flash movies were…

  14. Influenza Vaccination Uptake and Associated Factors among Elderly Population in Hong Kong: The Application of the Health Belief Model

    Science.gov (United States)

    Mo, P. K. H.; Lau, J. T. F.

    2015-01-01

    The impact of influenza on elderly can be severe and fatal. Influenza vaccination (IV) has been shown to be effective in reducing influenza-related complications, but the IV uptake among elderly in Hong Kong remains low. This study investigated the prevalence and factors associated with IV among Chinese elderly in Hong Kong using the Health Belief…

  15. The "Magic" of Tutorial Centres in Hong Kong: An Analysis of Media Marketing and Pedagogy in a Tutorial Centre

    Science.gov (United States)

    Koh, Aaron

    2014-01-01

    Why do more than three-quarters of Hong Kong's senior secondary students flock to tutorial centres like moths to light? What is the "magic" that is driving the popularity of the tutorial centre enterprise? Indeed, looking at the ongoing boom of tutorial centres in Hong Kong (there are almost 1,000 of them), it is difficult not to ask…

  16. Building a Connected Classroom: Teachers' Narratives about Managing the Cultural Diversity of Ethnic Minority Students in Hong Kong Secondary Schools

    Science.gov (United States)

    Hue, Ming-Tak; Kennedy, Kerry John

    2013-01-01

    Many Hong Kong schools are concerned about their growing numbers of ethnic minority students. When these students are enrolled in Hong Kong secondary schools, how their cultural diversity is catered for becomes critical. This article examines how teachers narrate the cultural diversity of ethnic minority students, who come from Pakistan, India,…

  17. The Impact of Curiosity and External Regulation on Intrinsic Motivation: An Empirical Study in Hong Kong Education

    Science.gov (United States)

    Hon-keung, Yau; Man-shan, Kan; Lai-fong, Cheng Alison

    2012-01-01

    The purposes of this paper are to identify: (1) the factors affecting the intrinsic motivation of university students in Hong Kong; and (2) gender differences in the perception of intrinsic motivation in Hong Kong higher education environment. The factors of curiosity and external regulation with intrinsic motivation are taken into investigation…

  18. Validity and reliability of questionnaires measuring physical activity self-efficacy, enjoyment, social support among Hong Kong Chinese children

    Science.gov (United States)

    Physical activity (PA) correlates have not been extensively studied in Hong Kong children. The aim of this study is to assess the validity and reliability of translated scales to measure PA related self-efficacy, enjoyment and social support in Hong Kong Chinese children. Sample 1 (n=273, aged 8–12 ...

  19. Impact of Globalization: A Study of Quality Assurance Systems of Higher Education in Hong Kong and Singapore.

    Science.gov (United States)

    Mok, Ka Ho

    2000-01-01

    Compares the implementation of quality assurance mechanisms at the City University of Hong Kong and the National University of Singapore. Discusses public policy contexts in the two countries, the introduction of "quality process reviews" in Hong Kong, managerialism and the new emphasis on educational efficiency, institutional self-assessment, and…

  20. Application of Sociology of Education on Early Childhood Curriculum and Pedagogic Practices in Hong Kong: Insight from David Riesman

    Science.gov (United States)

    Lau, Grace; Ho, Kwok Keung

    2016-01-01

    This paper will present multiple themes that are intermingled with one another, aiming to bring an overview of sociology of education and its application in the Hong Kong situation. One of the themes concerns how sociology of education has intertwined with the socio-political aspect of Hong Kong before and after year 1997 resulting in different…