WorldWideScience

Sample records for high-quality studies establishing

  1. Optical studies of high quality synthetic diamond

    International Nuclear Information System (INIS)

    Sharp, S.J.

    1999-01-01

    This thesis is concerned with the study of fundamental and defect induced optical properties of synthetic diamond grown using high pressure, high temperature (HPHT) synthesis or chemical vapour deposition (CVD). The primary technique used for investigation is cathodoluminescence (including imaging and decay-time measurements) in addition to other forms of optical spectroscopy. This thesis is timely in that the crystallinity and purity of synthetic diamond has increased ten fold over the last few years. The diamond exciton emission, which is easily quenched by the presence of defects, is studied in high quality samples in detail. In addition the ability now exists to engineer the isotopic content of synthetic diamond to a high degree of accuracy. The experimental chapters are divided as follows: Chapter 2: High resolution, low temperature spectra reveal a splitting of the free-exciton phonon recombination emission peaks and the bound-exciton zero phonon line. Included are measurements of the variation in intensity and decay-time as a function of temperature. Chapter 3: The shift in energy of the phonon-assisted free-exciton phonon replicas with isotopic content has been measured. The shift is in agreement with the results of interatomic force model for phonon scattering due to isotope disorder. Chapter 4: A study of the shift in energy with isotopic content of the diamond of the GR1 band due to the neutral vacancy has allowed a verification of the theoretical predictions due to the Jahn Teller effect. Chapter 5: The spatial distribution of the free-exciton luminescence is studied in HPHT synthetic and CVD diamond. A variation in intensity with distance from the surface is interpreted as a significant non-radiative loss of excitons to the surface. Chapter 6: The decay-times of all known self-interstitial related centres have been measured in order to calculate the concentration of these centres present in electron irradiated diamond. (author)

  2. High Quality Data for Grid Integration Studies

    Energy Technology Data Exchange (ETDEWEB)

    Clifton, Andrew; Draxl, Caroline; Sengupta, Manajit; Hodge, Bri-Mathias

    2017-01-22

    As variable renewable power penetration levels increase in power systems worldwide, renewable integration studies are crucial to ensure continued economic and reliable operation of the power grid. The existing electric grid infrastructure in the US in particular poses significant limitations on wind power expansion. In this presentation we will shed light on requirements for grid integration studies as far as wind and solar energy are concerned. Because wind and solar plants are strongly impacted by weather, high-resolution and high-quality weather data are required to drive power system simulations. Future data sets will have to push limits of numerical weather prediction to yield these high-resolution data sets, and wind data will have to be time-synchronized with solar data. Current wind and solar integration data sets are presented. The Wind Integration National Dataset (WIND) Toolkit is the largest and most complete grid integration data set publicly available to date. A meteorological data set, wind power production time series, and simulated forecasts created using the Weather Research and Forecasting Model run on a 2-km grid over the continental United States at a 5-min resolution is now publicly available for more than 126,000 land-based and offshore wind power production sites. The National Solar Radiation Database (NSRDB) is a similar high temporal- and spatial resolution database of 18 years of solar resource data for North America and India. The need for high-resolution weather data pushes modeling towards finer scales and closer synchronization. We also present how we anticipate such datasets developing in the future, their benefits, and the challenges with using and disseminating such large amounts of data.

  3. Synthesis and spectroscopic study of high quality alloy Cdx S ...

    Indian Academy of Sciences (India)

    Wintec

    In the present study, we report the synthesis of high quality CdxZn1–xS nanocrystals alloy at. 150°C with .... (XRD) using a Siemens model D 500, powder X-ray ... decays were analysed using IBH DAS6 software. 3. ... This alloying process is.

  4. Establishing High-Quality Prostate Brachytherapy Using a Phantom Simulator Training Program

    Energy Technology Data Exchange (ETDEWEB)

    Thaker, Nikhil G. [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Kudchadker, Rajat J. [Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Swanson, David A. [Department of Urology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Albert, Jeffrey M. [Department of Radiation Oncology, Banner Health, Loveland/Greeley, Colorado (United States); Mahmood, Usama; Pugh, Thomas J.; Boehling, Nicholas S. [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Bruno, Teresa L. [Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Prestidge, Bradley R. [Department of Radiation Oncology, Bon Secours Health System, Norfolk, Virginia (United States); Crook, Juanita M. [Department of Radiation Oncology, Cancer Center for the Southern Interior, Kelowna, British Columbia (Canada); Cox, Brett W.; Potters, Louis [Department of Radiation Medicine, North Shore-LIJ Health System, New Hyde Park, New York (United States); Moran, Brian J. [Chicago Prostate Center, Westmont, Illinois (United States); Keyes, Mira [Department of Radiation Oncology, British Columbia Cancer Agency, Vancouver Center, Vancouver, British Columbia (Canada); Kuban, Deborah A. [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Frank, Steven J., E-mail: sjfrank@mdanderson.org [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States)

    2014-11-01

    Purpose: To design and implement a unique training program that uses a phantom-based simulator to teach the process of prostate brachytherapy (PB) quality assurance and improve the quality of education. Methods and Materials: Trainees in our simulator program were practicing radiation oncologists, radiation oncology residents, and fellows of the American Brachytherapy Society. The program emphasized 6 core areas of quality assurance: patient selection, simulation, treatment planning, implant technique, treatment evaluation, and outcome assessment. Using the Iodine 125 ({sup 125}I) preoperative treatment planning technique, trainees implanted their ultrasound phantoms with dummy seeds (ie, seeds with no activity). Pre- and postimplant dosimetric parameters were compared and correlated using regression analysis. Results: Thirty-one trainees successfully completed the simulator program during the period under study. The mean phantom prostate size, number of seeds used, and total activity were generally consistent between trainees. All trainees met the V100 >95% objective both before and after implantation. Regardless of the initial volume of the prostate phantom, trainees' ability to cover the target volume with at least 100% of the dose (V100) was not compromised (R=0.99 pre- and postimplant). However, the V150 had lower concordance (R=0.37) and may better reflect heterogeneity control of the implant process. Conclusions: Analysis of implants from this phantom-based simulator shows a high degree of consistency between trainees and uniformly high-quality implants with respect to parameters used in clinical practice. This training program provides a valuable educational opportunity that improves the quality of PB training and likely accelerates the learning curve inherent in PB. Prostate phantom implantation can be a valuable first step in the acquisition of the required skills to safely perform PB.

  5. Establishing High-Quality Prostate Brachytherapy Using a Phantom Simulator Training Program

    International Nuclear Information System (INIS)

    Thaker, Nikhil G.; Kudchadker, Rajat J.; Swanson, David A.; Albert, Jeffrey M.; Mahmood, Usama; Pugh, Thomas J.; Boehling, Nicholas S.; Bruno, Teresa L.; Prestidge, Bradley R.; Crook, Juanita M.; Cox, Brett W.; Potters, Louis; Moran, Brian J.; Keyes, Mira; Kuban, Deborah A.; Frank, Steven J.

    2014-01-01

    Purpose: To design and implement a unique training program that uses a phantom-based simulator to teach the process of prostate brachytherapy (PB) quality assurance and improve the quality of education. Methods and Materials: Trainees in our simulator program were practicing radiation oncologists, radiation oncology residents, and fellows of the American Brachytherapy Society. The program emphasized 6 core areas of quality assurance: patient selection, simulation, treatment planning, implant technique, treatment evaluation, and outcome assessment. Using the Iodine 125 ( 125 I) preoperative treatment planning technique, trainees implanted their ultrasound phantoms with dummy seeds (ie, seeds with no activity). Pre- and postimplant dosimetric parameters were compared and correlated using regression analysis. Results: Thirty-one trainees successfully completed the simulator program during the period under study. The mean phantom prostate size, number of seeds used, and total activity were generally consistent between trainees. All trainees met the V100 >95% objective both before and after implantation. Regardless of the initial volume of the prostate phantom, trainees' ability to cover the target volume with at least 100% of the dose (V100) was not compromised (R=0.99 pre- and postimplant). However, the V150 had lower concordance (R=0.37) and may better reflect heterogeneity control of the implant process. Conclusions: Analysis of implants from this phantom-based simulator shows a high degree of consistency between trainees and uniformly high-quality implants with respect to parameters used in clinical practice. This training program provides a valuable educational opportunity that improves the quality of PB training and likely accelerates the learning curve inherent in PB. Prostate phantom implantation can be a valuable first step in the acquisition of the required skills to safely perform PB

  6. Integration study of high quality teaching resources in universities

    Directory of Open Access Journals (Sweden)

    Honglu Liu

    2012-12-01

    Full Text Available Purpose: The development level and quality of education depend on the merits and efficiency in the use of teaching resources, especially in the case of obvious contradiction between the demand and supply of teaching resources. So to integrate teaching resources, improve the efficiency in the use of high quality teaching resources, and take the road of content development to enhance the competitiveness of education has become very important and urgent.Design/methodology/approach: On the basis of analysis on the teaching resources of universities and the problems they faced, this paper introduced the basic concepts of cloud storage, and built the integration architecture of high quality teaching resources in universities based on the cloud storage.Findings and Originality/value: The HDFS-based cloud storage proposed in this paper is a dynamically adjustable and Internet-based storage solution, and the users can access storage targets using the network through a common and easy-to-use protocol and application programming interfaces. This new technology is useful for end users benefits. With the continuous development and improvement of cloud storage, it will necessarily result in more and more applications in the institutions of higher learning and education network.Originality/value: This paper introduced the cloud storage into the integration of high quality teaching resources in universities first and as a new form of service, it can be a good solution.

  7. Study on the Introduction of High-Quality Educational Resources for Sino-Foreign Cooperative Education

    Science.gov (United States)

    Jinhui, Lin

    2016-01-01

    In Sino-foreign cooperative education, high-quality introduced educational resources must benefit the growth and development of students, facilitate the school's capacity building and the improvement of overall educational standards, and promote national socioeconomic development. It is necessary to establish and perfect the various working…

  8. Theoretical-Experimental study on the electroslag remelting technology of high quality steels

    International Nuclear Information System (INIS)

    Robles P, E.F.

    1993-01-01

    This is a theoretical-experimental laboratory study on the Electroslag Remelting Technology (ESRT) of high quality steels. The objective of this study was to analyze the problems that this technology entails and thus facilitate its industrial application in Mexico. The study was carried out using a 1 Kg. capacity furnace, the behavior of different fluxes on the remelting of 1018 AISI carbon steel was established and a slag 70F/15/15 was selected for the remelting of H-13 AISI hot work tool steel. From the experimental results it was possible to establish a flux manufacture route, the electrode conditioning necessary for the experiments, and the critical points of the process. It was demonstrated that the crucible and electrode advance system are the more critical points in the furnace manufacture, that the start up is fundamental for the remelting continuity and that the CaF 2 base slags are more recommendable for special steels refining. It has been proven that it is possible to experiment with little laboratory electroslag furnaces. (Author)

  9. The Barriers to High-Quality Inpatient Pain Management: A Qualitative Study.

    Science.gov (United States)

    Lin, Richard J; Reid, M Carrington; Liu, Lydia L; Chused, Amy E; Evans, Arthur T

    2015-09-01

    The current literature suggests deficiencies in the quality of acute pain management among general medical inpatients. The aim of this qualitative study is to identify potential barriers to high-quality acute pain management among general medical inpatients at an urban academic medical center during a 2-year period. Data are collected using retrospective chart reviews, survey questionnaires, and semistructured, open-ended interviews of 40 general medical inpatients who have experienced pain during their hospitalization. Our results confirm high prevalence and disabling impacts of pain and significant patient- and provider-related barriers to high-quality acute pain management. We also identify unique system-related barriers such as time delay and pain management culture. Efforts to improve the pain management experience of general medical inpatients will need to address all these barriers. © The Author(s) 2014.

  10. THE LEAN SIX SIGMAAPPROACH FOR PROCESS IMPROVEMENT: A CASE STUDY IN A HIGH QUALITY TUSCANY WINERY

    Directory of Open Access Journals (Sweden)

    Riccardo Bettini

    2012-06-01

    Full Text Available This paper describes the application of a Lean Six Sigma (LSS project to a winemaking process in a high-quality, Italian winery. LSS is used to focus on the problem through a quantitative analysis of waste and quality performances. The LSS basic algorithm (called “DMAIC” helps to detect and quantify critical aspects of the process for transferring liquid used in the cellar. The improvement solution is developed and applied through the modification of the cellar system and the process procedure. The results obtained with this solution are shown and discussed in this paper, so too the long term reliability of the improved process analyzed. The results obtained by this case study can help to understand the importance of the LSS method to drive the improvement of agricultural and agrofood productions also in terms of environmental impact which is strongly connected to waste reduction.

  11. Chemical and biological studies on producing high quality biscuits with irradiated tomato wastes

    International Nuclear Information System (INIS)

    Nassef, A.E.

    2005-01-01

    The present investigation has been carried out to produce high quality biscuits for treatment of some special diseases. In this study, the total tomato processing wastes were used as new source of protein in which the most predominate elements were found to be phosphorus, potassium and magnesium. Phenyl alanine was found to be the first limiting amino acid, while lysine was the second limiting amino acid. It was found to contain about 30.66% fiber and 28.1% protein. The total tomato processing wastes remain unutilized and they not only add to the disposal problem, but also aggravate environmental pollution. Tomato wastes were irradiated in two doses (1.5 and 2.5 KGy) for preservation. Biscuits were made with supplementation of 5, 10 and 15% tomato wastes. All samples of biscuits were examined for chemical composition and organoleptic evaluation. Biological assay was carried out on rats fed biscuits containing 15% irradiated and non-irradiated tomato wastes. The weight gain, serum cholesterol and triglycerides were determined. Internal organs were also followed. The results obtained showed that 15% tomato wastes biscuit had the highest content of lysine, isoleucine and fiber (6.36, 2.72 and 24.80, respectively) and also scored a good grade. Weight gain, cholesterol and triglycerides were reduced comparable to control and there was no effect of irradiation on the rats internal organs

  12. High quality transmission Kikuchi diffraction analysis of deformed alloys - Case study

    International Nuclear Information System (INIS)

    Tokarski, Tomasz; Cios, Grzegorz; Kula, Anna; Bała, Piotr

    2016-01-01

    Modern scanning electron microscopes (SEM) equipped with thermally assisted field emission guns (Schottky FEG) are capable of imaging with a resolution in the range of several nanometers or better. Simultaneously, the high electron beam current can be used, which enables fast chemical and crystallographic analysis with a higher resolution than is normally offered by SEM with a tungsten cathode. The current resolution that limits the EDS and EBSD analysis is related to materials' physics, particularly to the electron-specimen interaction volume. The application of thin, electron-transparent specimens, instead of bulk samples, improves the resolution and allows for the detailed analysis of very fine microstructural features. Beside the typical imaging mode, it is possible to use a standard EBSD camera in such a configuration that only transmitted and scattered electrons are detected. This modern approach was successfully applied to various materials giving rise to significant resolution improvement, especially for the light element magnesium based alloys. This paper presents an insight into the application of the transmission Kikuchi diffraction (TKD) technique applied to the most troublesome, heavily-deformed materials. In particular, the values of the highest possible acquisition rates for high resolution and high quality mapping were estimated within typical imaging conditions of stainless steel and magnesium-yttrium alloy. - Highlights: •Monte Carlo simulations were used to simulate EBSD camera intensity for various measuring conditions. •Transmission Kikuchi diffraction parameters were evaluated for highly deformed, light and heavy elements based alloys. •High quality maps with 20 nm spatial resolution were acquired for Mg and Fe based alloys. •High speed TKD measurements were performed at acquisition rates comparable to the reflection EBSD.

  13. Comparative study of active plasma lenses in high-quality electron accelerator transport lines

    Science.gov (United States)

    van Tilborg, J.; Barber, S. K.; Benedetti, C.; Schroeder, C. B.; Isono, F.; Tsai, H.-E.; Geddes, C. G. R.; Leemans, W. P.

    2018-05-01

    Electrically discharged active plasma lenses (APLs) are actively pursued in compact high-brightness plasma-based accelerators due to their high-gradient, tunable, and radially symmetric focusing properties. In this manuscript, the APL is experimentally compared with a conventional quadrupole triplet, highlighting the favorable reduction in the energy dependence (chromaticity) in the transport line. Through transport simulations, it is explored how the non-uniform radial discharge current distribution leads to beam-integrated emittance degradation and a charge density reduction at focus. However, positioning an aperture at the APL entrance will significantly reduce emittance degradation without additional loss of charge in the high-quality core of the beam. An analytical model is presented that estimates the emittance degradation from a short beam driving a longitudinally varying wakefield in the APL. Optimizing laser plasma accelerator operation is discussed where emittance degradation from the non-uniform discharge current (favoring small beams inside the APL) and wakefield effects (favoring larger beam sizes) is minimized.

  14. Application of high quality antiproton beam to study charmonium and exotics above DD-bar threshold

    International Nuclear Information System (INIS)

    Barabanov, M.Y.; Vodopyanov, A.S.

    2014-01-01

    The spectroscopy of charmonium and exotic states with hidden charm is discussed. It is a good testing tool for theories of strong interactions including QCD in both perturbative and non-perturbative regime, lattice QCD, potential models and phenomenological models. An elaborated analysis of charmonium and charmed hybrid spectrum is given, and attempts to interpret recent experimental data in the above DD-bar threshold region are considered. Experiments using antiproton beam take advantage of the intensive production of particle-antiparticle pairs in antiproton-proton annihilations. Experimental data from different collaboration are analyzed with special attention given to new states with hidden charm that were discovered recently. Some of these states can be interpreted as higher-laying S, P and D wave charmonium states. But much more data on different decay modes are needed before firmer conclusions can be made. These data can be derived directly from the experiments using high quality antiproton beam with momentum up to 15 GeV/c. (authors)

  15. Highly qualified does not equal high quality: A study of urban stakeholders' perceptions of quality in science teaching

    Science.gov (United States)

    Miranda, Rommel Joseph

    By employing qualitative methods, this study sought to determine the perceptions that urban stakeholders hold about what characteristics should distinguish a high school science teacher whom they would consider to demonstrate high quality in science teaching. A maximum variation sample of six science teachers, three school administrators, six parents and six students from a large urban public school district were interviewed using semi-structured, in-depth interview techniques. From these data, a list of observable characteristics which urban stakeholders hold as evidence of high quality in science teaching was generated. Observational techniques were utilized to determine the extent to which six urban high school science teachers, who meet the NCLB Act criteria for being "highly qualified", actually possessed the characteristics which these stakeholders hold as evidence of high quality in science teaching. Constant comparative analysis was used to analyze the data set. The findings suggest that urban stakeholders perceive that a high school science teacher who demonstrates high quality in science teaching should be knowledgeable about their subject matter, their student population, and should be resourceful; should possess an academic background in science and professional experience in science teaching; should exhibit professionalism, a passion for science and teaching, and a dedication to teaching and student learning; should be skillful in planning and preparing science lessons and in organizing the classroom, in presenting the subject matter to students, in conducting a variety of hands-on activities, and in managing a classroom; and should assess whether students complete class goals and objectives, and provide feedback about grades for students promptly. The findings further reveal that some of the urban high school science teachers who were deemed to be "highly qualified", as defined by the NCLB Act, engaged in practices that threatened quality in science

  16. Can microbes compete with cows for sustainable protein production - A feasibility study on high quality protein

    DEFF Research Database (Denmark)

    Vestergaard, Mike; Chan, Siu Hung Joshua; Jensen, Peter Ruhdal

    2016-01-01

    An increasing population and their increased demand for high-protein diets will require dramatic changes in the food industry, as limited resources and environmental issues will make animal derived foods and proteins, gradually more unsustainable to produce. To explore alternatives to animal...... derived proteins, an economic model was built around the genome-scale metabolic network of E. coli to study the feasibility of recombinant protein production as a food source. Using a novel model, we predicted which microbial production strategies are optimal for economic return, by capturing the tradeoff...... between the market prices of substrates, product output and the efficiency of microbial production. A case study with the food protein, Bovine Alpha Lactalbumin was made to evaluate the upstream economic feasibilities. Simulations with different substrate profiles at maximum productivity were used...

  17. Can microbes compete with cows for sustainable protein production - A feasibility study on high quality protein.

    Science.gov (United States)

    Vestergaard, Mike; Chan, Siu Hung Joshua; Jensen, Peter Ruhdal

    2016-11-08

    An increasing population and their increased demand for high-protein diets will require dramatic changes in the food industry, as limited resources and environmental issues will make animal derived foods and proteins, gradually more unsustainable to produce. To explore alternatives to animal derived proteins, an economic model was built around the genome-scale metabolic network of E. coli to study the feasibility of recombinant protein production as a food source. Using a novel model, we predicted which microbial production strategies are optimal for economic return, by capturing the tradeoff between the market prices of substrates, product output and the efficiency of microbial production. A case study with the food protein, Bovine Alpha Lactalbumin was made to evaluate the upstream economic feasibilities. Simulations with different substrate profiles at maximum productivity were used to explore the feasibility of recombinant Bovine Alpha Lactalbumin production coupled with market prices of utilized materials. We found that recombinant protein production could be a feasible food source and an alternative to traditional sources.

  18. Can microbes compete with cows for sustainable protein production - A feasibility study on high quality protein

    Science.gov (United States)

    Vestergaard, Mike; Chan, Siu Hung Joshua; Jensen, Peter Ruhdal

    2016-11-01

    An increasing population and their increased demand for high-protein diets will require dramatic changes in the food industry, as limited resources and environmental issues will make animal derived foods and proteins, gradually more unsustainable to produce. To explore alternatives to animal derived proteins, an economic model was built around the genome-scale metabolic network of E. coli to study the feasibility of recombinant protein production as a food source. Using a novel model, we predicted which microbial production strategies are optimal for economic return, by capturing the tradeoff between the market prices of substrates, product output and the efficiency of microbial production. A case study with the food protein, Bovine Alpha Lactalbumin was made to evaluate the upstream economic feasibilities. Simulations with different substrate profiles at maximum productivity were used to explore the feasibility of recombinant Bovine Alpha Lactalbumin production coupled with market prices of utilized materials. We found that recombinant protein production could be a feasible food source and an alternative to traditional sources.

  19. Availability of high quality weather data measurements

    DEFF Research Database (Denmark)

    Andersen, Elsa; Johansen, Jakob Berg; Furbo, Simon

    In the period 2016-2017 the project “Availability of high quality weather data measurements” is carried out at Department of Civil Engineering at the Technical University of Denmark. The aim of the project is to establish measured high quality weather data which will be easily available...... for the building energy branch and the solar energy branch in their efforts to achieve energy savings and for researchers and students carrying out projects where measured high quality weather data are needed....

  20. Gender differences in the association of a high quality job and self-esteem over time: A multiwave study

    OpenAIRE

    Keller, Anita C.; Meier, Laurenz L.; Gross, Sven; Semmer, Norbert K.

    2015-01-01

    High self-esteem often predicts job-related outcomes, such as high job satisfaction or high status. Theoretically, high quality jobs (HQJs) should be important for self-esteem, as they enable people to use a variety of skills and attribute accomplishments to themselves, but research findings are mixed. We expected reciprocal relationships between self-esteem and HQJ. However, as work often is more important for the status of men, we expected HQJ to have a stronger influence on self-esteem for...

  1. Case study of establishing a clean production

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Yong Kun; Nam, Yoon Mi [Korea Environment Institute, Seoul (Korea)

    1998-12-01

    This study was implemented to derive suggestions for improving policies in Korea through the examination and analysis on the present policies related to the clean production and its establishment in enterprises. The characters of concept on clean production presented in pollution prevention, waste minimization, zero emission, environmental friendly design, and industrial ecology were analyzed and the mechanism for implementing clean production and government policy were arranged comprehensively. The related policies of major countries with international organizations including UNEP (United Nations Environment Program) and EU (European Union) were reviewed and compared to those of Korea to propose future policy plan. 73 refs., 3 figs., 30 tabs.

  2. Base-line studies for DAE establishments

    International Nuclear Information System (INIS)

    Puranik, V.D.

    2012-01-01

    The Department of Atomic Energy has establishments located in various regions of the country and they include front-end fuel cycle facilities, nuclear power stations, back-end fuel cycle facilities and facilities for research and societal applications. These facilities handle naturally occurring radionuclides such as uranium, thorium and a variety of man-made radionuclides. These radionuclides are handled with utmost care so that they do not affect adversely the occupational workers or the members of public residing nearby. There is safety culture of the highest standard existing in all DAE establishments and it matches with the international standards. In addition, there is a perpetual environmental monitoring program carried out by the Environmental Survey Laboratories (ESLs) located at all DAE establishments. The environmental data generated by such program is studied regularly by experts to ensure compliance with the regulatory requirements. The regulatory requirements in the country are of international standards and ensure adequate protection of workers and members of public. In addition to such continued monitoring program and studies being carried out for the ongoing projects, base-line studies are carried out for all the new projects of the DAE. The purpose of the base-line studies is to establish a detailed base-line data set for a new DAE location well before the foundation stone is laid, so that the data collected when there is no departmental activity can be compared with the data generated later by the ESL. The data so generated is site specific and it varies from place to place depending upon the location of the site, e.g., inland or coastal, the presence of water bodies and pattern of irrigation, the geological characteristics of the location, the local culture and habits of the people, population density and urban or rural background. The data to be recorded as base-line data is generated over a period of at least one year covering all the seasons

  3. Study of the weak localization in high quality two dimensional p-GaAs/AIGaAs systems

    International Nuclear Information System (INIS)

    Yasin, C.E.; Simmons, M.Y.; Hamilton, A.R.; Pepper, M.; Ritchie, D.A.

    2002-01-01

    Full text: Despite numerous experimental and theoretical work over the past ∼ 30 years, the nature of the ground state in 2D semiconductor systems remains a subject of controversy. Does the anomalous 'metallic' behavior observed at B = 0 imply the existence of a new 2D 'metallic' ground state or can it be explained within the conventional Fermi liquid theory? To address this question, we have investigated the single particle phase coherent 'weak localization' effect in high quality 2D p-GaAs systems that shows an apparent ' metallic' behavior at B = 0. We have performed detailed temperature dependent magnetoresistance measurements at different carrier densities and fit the experimental data to various models of weak localization in order to extract the phase coherence time, τ φ . We find that as the sample quality increases the mean free path increases, and weak localization must be treated beyond the diffusion approximation, making the data analysis more complex. Our result shows that when these more complex models are applied to the experimental data the systems are well described by Fermi liquid theory despite the strong interactions (r s ∼ 20), indicating that there is no 'metallic' phase in 2D at B = 0

  4. Comprehensive Technical Support for High-Quality Anthracite Production: A Case Study in the Xinqiao Coal Mine, Yongxia Mining Area, China

    Directory of Open Access Journals (Sweden)

    Wei Zhang

    2015-12-01

    Full Text Available The effective production of high-quality anthracite has attracted increasing global attention. Based on the coal occurrence in Yongxia Mining Area and mining conditions of a coalface in Xinqiao Coal Mine, we proposed a systematic study on the technical support for the production of high-quality anthracite. Six key steps were explored, including coal falling at the coalface, transport, underground bunker storage, main shaft hoisting, coal preparation on the ground, and railway wagon loading. The study resulted in optimized running parameters for the shearers, and the rotating patterns of the shearer drums was altered (one-way cutting was employed. Mining height and roof supporting intensity were reduced. Besides, loose presplitting millisecond blasting and mechanized mining were applied to upgrade the coal quantity and the lump coal production rate. Additionally, the coalface end transloading, coalface crush, transport systems, underground storage, and main shaft skip unloading processes were improved, and fragmentation-prevention techniques were used in the washing and railway wagon loading processes. As a result, the lump coal production rate was maintained at a high level and fragmentation was significantly reduced. Because of using the parameters and techniques determined in this research, high-quality coal production and increased profits were achieved. The research results could provide theoretical guidance and methodology for other anthracite production bases.

  5. Legislation should support optimal breastfeeding practices and access to low-cost, high-quality complementary foods: Indonesia provides a case study.

    Science.gov (United States)

    Soekarjo, Damayanti; Zehner, Elizabeth

    2011-10-01

    It is important to support women to exclusively breastfeed for 6 months and continue breastfeeding for 24 months and beyond. It is also necessary to provide the poor with access to affordable ways to improve the quality of complementary foods. Currently, many countries do not have the legal and policy environment necessary to support exclusive and continued breastfeeding. Legislative and policy changes are also necessary for introducing complementary food supplements, allowing them to be marketed to those who need them, and ensuring that marketing remains appropriate and in full compliance with the International Code of Marketing of Breastmilk Substitutes. This paper aims to illustrate the above with examples from Indonesia and to identify legislative requirements for supporting breastfeeding and enabling appropriate access to high-quality complementary food supplements for children 6-24 months of age. Requirements include improved information, training, monitoring and enforcement systems for the International Code of Marketing of Breastmilk Substitutes; implementation and monitoring of the Baby-Friendly Hospital Initiative; establishment of a registration category for complementary food supplements to enhance availability of high-quality, low-cost fortified products to help improve young child feeding; clear identification and marketing of these products as complementary food supplements for 6-24-month-olds so as to promote proper use and not interfere with breastfeeding. © 2011 Blackwell Publishing Ltd.

  6. Average effect estimates remain similar as evidence evolves from single trials to high-quality bodies of evidence: a meta-epidemiologic study.

    Science.gov (United States)

    Gartlehner, Gerald; Dobrescu, Andreea; Evans, Tammeka Swinson; Thaler, Kylie; Nussbaumer, Barbara; Sommer, Isolde; Lohr, Kathleen N

    2016-01-01

    The objective of our study was to use a diverse sample of medical interventions to assess empirically whether first trials rendered substantially different treatment effect estimates than reliable, high-quality bodies of evidence. We used a meta-epidemiologic study design using 100 randomly selected bodies of evidence from Cochrane reports that had been graded as high quality of evidence. To determine the concordance of effect estimates between first and subsequent trials, we applied both quantitative and qualitative approaches. For quantitative assessment, we used Lin's concordance correlation and calculated z-scores; to determine the magnitude of differences of treatment effects, we calculated standardized mean differences (SMDs) and ratios of relative risks. We determined qualitative concordance based on a two-tiered approach incorporating changes in statistical significance and magnitude of effect. First trials both overestimated and underestimated the true treatment effects in no discernible pattern. Nevertheless, depending on the definition of concordance, effect estimates of first trials were concordant with pooled subsequent studies in at least 33% but up to 50% of comparisons. The pooled magnitude of change as bodies of evidence advanced from single trials to high-quality bodies of evidence was 0.16 SMD [95% confidence interval (CI): 0.12, 0.21]. In 80% of comparisons, the difference in effect estimates was smaller than 0.5 SMDs. In first trials with large treatment effects (>0.5 SMD), however, estimates of effect substantially changed as new evidence accrued (mean change 0.68 SMD; 95% CI: 0.50, 0.86). Results of first trials often change, but the magnitude of change, on average, is small. Exceptions are first trials that present large treatment effects, which often dissipate as new evidence accrues. Copyright © 2016 Elsevier Inc. All rights reserved.

  7. Cavity quantum electrodynamics studies with site-controlled InGaAs quantum dots integrated into high quality microcavities

    DEFF Research Database (Denmark)

    Reitzenstein, S.; Schneider, C.; Albert, F.

    2011-01-01

    Semiconductor quantum dots (QDs) are fascinating nanoscopic structures for photonics and future quantum information technology. However, the random position of self-organized QDs inhibits a deterministic coupling in devices relying on cavity quantum electrodynamics (cQED) effects which complicates......, e.g., the large scale fabrication of quantum light sources. As a result, large efforts focus on the growth and the device integration of site-controlled QDs. We present the growth of low density arrays of site-controlled In(Ga)As QDs where shallow etched nanoholes act as nucleation sites...... linewidth, the oscillator strength and the quantum efficiency. A stacked growth of strain coupled SCQDs forming on wet chemically etched nanoholes provide the smallest linewidth with an average value of 210 μeV. Using time resolved photoluminescence studies on samples with a varying thickness of the capping...

  8. High Quality of Diabetes Care Based Upon Individualised Treatment Goals - A Cross Sectional Study in 4784 Patients in Germany.

    Science.gov (United States)

    Kloos, C; Müller, N; Hartmann, P; Lehmann, T; Sämann, A; Roth, J; Wolf, G; Müller, U A

    2016-05-01

    Recent guidelines recommend an individualized approach towards patients with diabetes mellitus. Data of a programme dealing with quality of diabetes care, "Diabetes TÜV" of the Deutsche BKK was reappraised in the light of recent evidence applying these recommendations. Data originates from a population-based study in primary diabetes care in Germany. Patients with diabetes mellitus insured by the Deutsche BKK were invited to participate. From 2000 to 2004 data of 4 784 patients participated. Double or multiple visits were not included. HbA1c was analysed in 0.5% categories and in age groups below and above 70 years. HbA1c was DCCT adjusted. A total of 368 patients with diabetes mellitus type 1 (DM1) (42% women, HbA1c 54 mmol/mol (7.1%), BP 136/79 mmHg) and 4 416 patients with diabetes type 2 (DM2) (44% women, HbA1c 48.6 mmol/mol (6.6%), BP 142/81 mmHg) were included.). An HbA1c of 53 mmol/mol (7%) or less was found in 70%, less than 64 mmol/mol (8%) in 87% of all patients, and higher than 86 mmol/mol (10%) in 2.8%. The detailed analysis shows that an HbA1c of  70 years 144 mmHg/diastolic BP:  70 years 80 mmHg). Using WHO grading, BP is mainly mildly elevated (grade 1: 41% (n=1942); grade 2, 17% (n=820) grade 3 6% (n=281). In 10 patients (0.2%) HbA1c above 86 mmol/mol (10.0%) coincides with a BP WHO grade 3. In recent years new evidence is available regarding treatment targets. The reappraisal of a cross sectional study of a quality assurance programme of a German health insurance in a differentiated way demonstrates that more than 2/3 of the people with diabetes mellitus meet their specific goals. Only very few patients are at imminent risk due to bad glycaemic control and high blood pressure. Old patients may be at risk of overtreatment. Strategies aiming at adapting pharmacological interventions in older patients must be conceived. © Georg Thieme Verlag KG Stuttgart · New York.

  9. Establishment of an Institute for Fusion Studies

    International Nuclear Information System (INIS)

    Hazeltine, R.D.

    1992-07-01

    The Institute for Fusion Studies is a national center for theoretical fusion plasma physics research. Its purposes are: (1) to conduct research on theoretical questions concerning the achievement of controlled fusion energy by means of magnetic confinement--including both fundamental problems of long-range significance, as well as shorter-term issues; (2) to serve as a center for information exchange, nationally and internationally, by hosting exchange visits, conferences, and workshops; (3) and to train students and postdoctoral research personnel for the fusion energy program and plasma physics research areas. The theoretical research results that are obtained by the Institute contribute mainly to the progress of national and international efforts in nuclear fusion research, whose goal is the development of fusion power.as a basic energy source. In addition to its primary focus on fusion physics, the Institute is also involved with research in related fields, such as advanced computing techniques, nonlinear dynamics, plasma astrophysics, and accelerator physics. The work of EFS scientists continued to receive national and international recognition. Numerous invited papers were given during the past year at workshops, conferences, and scientific meetings. Last year IFS scientists published 95 scientific articles in technical journals and monographs

  10. Integrated marketing communications in high-quality hotels of central and southern Dalmatia: a study from the perspective of managers and guests

    Directory of Open Access Journals (Sweden)

    Maja Šerić

    2012-07-01

    Full Text Available Although the implementation of Integrated Marketing Communications (IMC has been studied in different contexts and countries all over the world, further contributions are needed to consolidate the concept. Little research has been done on the integration of marketing communications in tourism-related sectors. Moreover, previous studies have focused mainly on managers’ opinions while overlooking consumers’ perceptions of IMC. The purpose of this research is to study in greater detail the IMC concept in the tourism sector, specifically in the hotels of Central and Southern Dalmatia, from a double perspective: managers-guests. Therefore, managers of 15 high-quality hotels and 118 guests were interviewed during April and May 2010. The results of descriptive statistical analysis showed a high degree of IMC implementation in hotels and a high degree of guests’ perceptions of IMC. However, the Mann-Whitney U test revealed small but significant differences between managers’ and guests’ perceptions of some of the IMC items. The findings of this study are expected to provide useful information to hotel managers, who deal with an increasingly competitive marketplace where traditional marketing approaches are no longer sufficient to differentiate themselves from their competitors. Thus, IMC should be considered as a new approach which might enable hotels to gain competitive advantages.

  11. Modelling of pedestrian level wind environment on a high-quality mesh: A case study for the HKPolyU campus

    DEFF Research Database (Denmark)

    Du, Yaxing; Mak, Cheuk Ming; Ai, Zhengtao

    2018-01-01

    Quality and efficiency of computational fluid dynamics (CFD) simulation of pedestrian level wind environment in a complex urban area are often compromised by many influencing factors, particularly mesh quality. This paper first proposes a systematic and efficient mesh generation method and then p......Quality and efficiency of computational fluid dynamics (CFD) simulation of pedestrian level wind environment in a complex urban area are often compromised by many influencing factors, particularly mesh quality. This paper first proposes a systematic and efficient mesh generation method...... and then performs detailed sensitivity analysis of some important computational parameters. The geometrically complex Hong Kong Polytechnic University (HKPolyU) campus is taken as a case study. Based on the high-quality mesh system, the influences of three important computational parameters, namely, turbulence...... model, near-wall mesh density and computational domain size, on the CFD predicted results of pedestrian level wind environment are quantitatively evaluated. Validation of CFD models is conducted against wind tunnel experimental data, where a good agreement is achieved. It is found that the proposed mesh...

  12. Effectiveness of feedback with a smartwatch for high-quality chest compressions during adult cardiac arrest: A randomized controlled simulation study.

    Science.gov (United States)

    Ahn, Chiwon; Lee, Juncheol; Oh, Jaehoon; Song, Yeongtak; Chee, Youngjoon; Lim, Tae Ho; Kang, Hyunggoo; Shin, Hyungoo

    2017-01-01

    Previous studies have demonstrated the potential for using smartwatches with a built-in accelerometer as feedback devices for high-quality chest compression during cardiopulmonary resuscitation. However, to the best of our knowledge, no previous study has reported the effects of this feedback on chest compressions in action. A randomized, parallel controlled study of 40 senior medical students was conducted to examine the effect of chest compression feedback via a smartwatch during cardiopulmonary resuscitation of manikins. A feedback application was developed for the smartwatch, in which visual feedback was provided for chest compression depth and rate. Vibrations from smartwatch were used to indicate the chest compression rate. The participants were randomly allocated to the intervention and control groups, and they performed chest compressions on manikins for 2 min continuously with or without feedback, respectively. The proportion of accurate chest compression depth (≥5 cm and ≤6 cm) was assessed as the primary outcome, and the chest compression depth, chest compression rate, and the proportion of complete chest decompression (≤1 cm of residual leaning) were recorded as secondary outcomes. The proportion of accurate chest compression depth in the intervention group was significantly higher than that in the control group (64.6±7.8% versus 43.1±28.3%; p = 0.02). The mean compression depth and rate and the proportion of complete chest decompressions did not differ significantly between the two groups (all p>0.05). Cardiopulmonary resuscitation-related feedback via a smartwatch could provide assistance with respect to the ideal range of chest compression depth, and this can easily be applied to patients with out-of-hospital arrest by rescuers who wear smartwatches.

  13. Evaluations of methods for the isolation of high quality RNA from bovine and cervine hide biopsies for use in gene expression studies

    Science.gov (United States)

    Molecular investigations of the ruminant response to ectoparasites at the parasite-host interface are critically dependent upon the quality of RNA. The complexity of ruminant skin decreases the capacity to obtain high quality RNA from biopsy samples, which directly affects the reliability of data pr...

  14. An online expert network for high quality information on occupational safety and health: cross-sectional study of user satisfaction and impact

    NARCIS (Netherlands)

    Rhebergen, Martijn D. F.; Lenderink, Annet F.; van Dijk, Frank J. H.; Hulshof, Carel T. J.

    2011-01-01

    Many people have difficulties finding information on health questions, including occupational safety and health (OSH) issues. One solution to alleviate these difficulties could be to offer questioners free-of-charge, online access to a network of OSH experts who provide tailored, high-quality

  15. A Novel Approach to High-Quality Postmortem Tissue Procurement: The GTEx Project

    NARCIS (Netherlands)

    Carithers, Latarsha J.; Ardlie, Kristin; Barcus, Mary; Branton, Philip A.; Britton, Angela; Buia, Stephen A.; Compton, Carolyn C.; Deluca, David S.; Peter-Demchok, Joanne; Gelfand, Ellen T.; Guan, Ping; Korzeniewski, Greg E.; Lockhart, Nicole C.; Rabiner, Chana A.; Rao, Abhi K.; Robinson, Karna L.; Roche, Nancy V.; Sawyer, Sherilyn J.; Segrè, Ayellet V.; Shive, Charles E.; Smith, Anna M.; Sobin, Leslie H.; Undale, Anita H.; Valentino, Kimberly M.; Vaught, Jim; Young, Taylor R.; Moore, Helen M.; Barker, Laura; Basile, Margaret; Battle, Alexis; Boyer, Joy; Bradbury, Debra; Bridge, Jason P.; Brown, Amanda; Burges, Robin; Choi, Christopher; Colantuoni, Deborah; Cox, Nancy; Dermitzakis, Emmanouil T.; Derr, Leslie K.; Dinsmore, Michael J.; Erickson, Kenyon; Fleming, Johnelle; Flutre, Timothée; Foster, Barbara A.; Gamazon, Eric R.; Getz, Gad; Gillard, Bryan M.; Guigo, Roderic; Hambright, Kenneth W.; Hariharan, Pushpa; Hasz, Rick; Im, Hae K.; Jewell, Scott; Karasik, Ellen; Kellis, Manolis; Kheradpour, Pouya; Koester, Susan; Koller, Daphne; Konkashbaev, Anuar; Lappalainen, Tuuli; Little, Roger; Liu, Jun; Lo, Edmund; Lonsdale, John T.; Lu, Chunrong; MacArthur, Daniel G.; Magazine, Harold; Maller, Julian B.; Marcus, Yvonne; Mash, Deborah C.; McCarthy, Mark I.; McLean, Jeffrey; Mestichelli, Bernadette; Miklos, Mark; Monlong, Jean; Mosavel, Magboeba; Moser, Michael T.; Mostafavi, Sara; Nicolae, Dan L.; Pritchard, Jonathan; Qi, Liqun; Ramsey, Kimberly; Rivas, Manuel A.; Robles, Barnaby E.; Rohrer, Daniel C.; Salvatore, Mike; Sammeth, Michael; Seleski, John; Shad, Saboor; Siminoff, Laura A.; Stephens, Matthew; Struewing, Jeff; Sullivan, Timothy; Sullivan, Susan; Syron, John; Tabor, David; Taherian, Mehran; Tejada, Jorge; Temple, Gary F.; Thomas, Jeffrey A.; Thomson, Alexander W.; Tidwell, Denee; Traino, Heather M.; Tu, Zhidong; Valley, Dana R.; Volpi, Simona; Walters, Gary D.; Ward, Lucas D.; Wen, Xiaoquan; Winckler, Wendy; Wu, Shenpei; Zhu, Jun

    2015-01-01

    The Genotype-Tissue Expression (GTEx) project, sponsored by the NIH Common Fund, was established to study the correlation between human genetic variation and tissue-specific gene expression in non-diseased individuals. A significant challenge was the collection of high-quality biospecimens for

  16. An online expert network for high quality information on occupational safety and health: cross-sectional study of user satisfaction and impact

    Directory of Open Access Journals (Sweden)

    Rhebergen Martijn DF

    2011-11-01

    Full Text Available Abstract Background Many people have difficulties finding information on health questions, including occupational safety and health (OSH issues. One solution to alleviate these difficulties could be to offer questioners free-of-charge, online access to a network of OSH experts who provide tailored, high-quality information. The aim of this study was to assess whether network quality, respectively information quality, as perceived by the questioners, is associated with questioners' overall satisfaction and to explore the impact of the information received on questioners' knowledge, work and work functioning. Methods We evaluated the experiences of OSH questioners with the online network ArboAntwoord.com over a two-year period. In this network, approximately 80 qualified experts are available to answer OSH questions. By means of a questionnaire, we assessed questioners' overall satisfaction with the network, whether the network was user-friendly, easily accessible and easy to handle and whether the information provided was complete, applicable and received in a timely manner. The impact of the information on questioners' knowledge, work or work functioning was explored with seven questions. In the study period, 460 unique OSH questioners asked 851 OSH questions. In total, 205 of the 460 questioners completed the questionnaire (response rate 45%. Results Of the responders, 71% were satisfied with the ArboAntwoord network. Multiple logistic regression analysis showed that the applicability of the information had a positive influence on the questioners' overall satisfaction (OR = 16.0, 95% CI: 7.0-36.4. Also, user friendliness of the network (OR = 3.3, 95% CI: 1.3-8.6 and completeness of the information provided (OR = 3.0, 95% CI: 1.3-6.8 were positively related to the questioners' satisfaction. For 74% of the questioners, the information helped to increase their knowledge and understanding. Overall, 25% of the questioners indicated that the received

  17. An online expert network for high quality information on occupational safety and health: cross-sectional study of user satisfaction and impact.

    Science.gov (United States)

    Rhebergen, Martijn D F; Lenderink, Annet F; van Dijk, Frank J H; Hulshof, Carel T J

    2011-11-23

    Many people have difficulties finding information on health questions, including occupational safety and health (OSH) issues. One solution to alleviate these difficulties could be to offer questioners free-of-charge, online access to a network of OSH experts who provide tailored, high-quality information. The aim of this study was to assess whether network quality, respectively information quality, as perceived by the questioners, is associated with questioners' overall satisfaction and to explore the impact of the information received on questioners' knowledge, work and work functioning. We evaluated the experiences of OSH questioners with the online network ArboAntwoord.com over a two-year period. In this network, approximately 80 qualified experts are available to answer OSH questions. By means of a questionnaire, we assessed questioners' overall satisfaction with the network, whether the network was user-friendly, easily accessible and easy to handle and whether the information provided was complete, applicable and received in a timely manner. The impact of the information on questioners' knowledge, work or work functioning was explored with seven questions. In the study period, 460 unique OSH questioners asked 851 OSH questions. In total, 205 of the 460 questioners completed the questionnaire (response rate 45%). Of the responders, 71% were satisfied with the ArboAntwoord network. Multiple logistic regression analysis showed that the applicability of the information had a positive influence on the questioners' overall satisfaction (OR = 16.0, 95% CI: 7.0-36.4). Also, user friendliness of the network (OR = 3.3, 95% CI: 1.3-8.6) and completeness of the information provided (OR = 3.0, 95% CI: 1.3-6.8) were positively related to the questioners' satisfaction. For 74% of the questioners, the information helped to increase their knowledge and understanding. Overall, 25% of the questioners indicated that the received information improved their work, work functioning

  18. Fabrication of high quality anodic aluminum oxide (AAO) on low purity aluminum—A comparative study with the AAO produced on high purity aluminum

    International Nuclear Information System (INIS)

    Michalska-Domańska, Marta; Norek, Małgorzata; Stępniowski, Wojciech J.; Budner, Bogusław

    2013-01-01

    Highlights: • Nanoporous alumina was fabricated by anodization in sulfuric acid solution with glycol. • The AAO manufacturing on low- and high-purity Al was compared. • The pores size was ranging between 30 and 50 nm. • No difference in the quality of the AAO fabricated on both Al types was observed. • The current vs. anodization time curves were recorded. -- Abstract: In this work the quality, arrangement, composition, and regularity of nanoporous AAO formed on the low-purity (AA1050) and high-purity aluminum during two-step anodization in a mixture of sulfuric acid solution (0.3 M), water and glycol (3:2, v/v), at various voltages (15, 20, 25, 30, 35 V) and at temperature of −1 °C, are investigated. The electrochemical conditions have allowed to obtain pores with the size ranging from 30 to 50 nm, which are much larger than those usually obtained by anodization in a pure sulfuric acid solution (<20 nm). The mechanism of the AAO growth is discussed. It was found that with the increase of applied anodizing voltage a number of incorporated sulfate ions in the aluminum oxide matrix increases, which was connected with the appearance of an unusual area in the current vs. time curves. On the surface of anodizing low- and high-purity aluminum, the formation of hillocks was observed, which was associated with the sulfate ions incorporation. The sulfate ions are replacing the oxygen atom/atoms in the AAO amorphous crystal structure and, consequently, the AAO template swells, the oxide cracks and uplifts causing the formation of hillocks. The same mechanism occurs for both low- and high-purity aluminum. Nanoporous AAO characterized by a very high regularity, not registered previously for low purity aluminum, was obtained. Furthermore, no significant difference in the regularity ratio between the AAO obtained on low- and high-purity aluminum, was observed. The electrochemical conditions applied in this study can be, thus, used for the fabrication of high quality

  19. Empirical Study Regarding the Trust Relationships Established in a Community

    Directory of Open Access Journals (Sweden)

    Florina-Valentina NICOLAE

    2016-12-01

    Full Text Available The paper that we present aims to address the issue of relationships naturally established in a community through some items that we consider relevant to the proposed topic. In this purpose, we have initiated a quantitative research, developed through a survey, based on questionnaire, self-managed and on line. The recorded answers are statistically interpreted, using IBM SPSS application. The results suggests that the perception of the subjects participating in the study on the relationships established with their communities, on the date of the study, is not clearly contoured.

  20. Fast High-Quality Noise

    DEFF Research Database (Denmark)

    Frisvad, Jeppe Revall; Wyvill, Geoff

    2007-01-01

    At the moment the noise functions available in a graphics programmer's toolbox are either slow to compute or they involve grid-line artifacts making them of lower quality. In this paper we present a real-time noise computation with no grid-line artifacts or other regularity problems. In other words......, we put a new tool in the box that computes fast high-quality noise. In addition to being free of artifacts, the noise we present does not rely on tabulated data (everything is computed on the fly) and it is easy to adjust quality vs. quantity for the noise. The noise is based on point rendering (like...... spot noise), but it extends to more than two dimensions. The fact that it is based on point rendering makes art direction of the noise much easier....

  1. Partnering to Establish and Study Simulation in International Nursing Education.

    Science.gov (United States)

    Garner, Shelby L; Killingsworth, Erin; Raj, Leena

    The purpose of this article was to describe an international partnership to establish and study simulation in India. A pilot study was performed to determine interrater reliability among faculty new to simulation when evaluating nursing student competency performance. Interrater reliability was below the ideal agreement level. Findings in this study underscore the need to obtain baseline interrater reliability data before integrating competency evaluation into a simulation program.

  2. A study on the establishment of national nuclear foreign policy

    International Nuclear Information System (INIS)

    Choi, Y.M.; Kim, H.S.; Lee, K.S.; Lee, B.Y.; Lee, J.S.; Choi, Y.L.

    1993-01-01

    The overall objective of this study is to analyze international non-proliferation circumstances, to suggest national strategies and tactics for international meetings non-proliferation and peaceful uses of nuclear energy, and to establish domestic non-proliferation systems for international credibility. This study suggests two revision proposals for the IAEA Statute Article VI as a means for the permanent membership in the Board, evaluates benefits and losses of the membership of the international export control regime, and suggests strategies for building a domestics nuclear export control system. This study contributes to enhancing international credibility and promoting self-reliance of nuclear technology in Korea. (Author)

  3. How to achieve safe, high-quality clinical studies with non-Medicinal Investigational Products? A practical guideline by using intra-bronchial carbon nanoparticles as case study.

    Science.gov (United States)

    Berger, M; Kooyman, P J; Makkee, M; van der Zee, J S; Sterk, P J; van Dijk, J; Kemper, E M

    2016-08-19

    Clinical studies investigating medicinal products need to comply with laws concerning good clinical practice (GCP) and good manufacturing practice (GMP) to guarantee the quality and safety of the product, to protect the health of the participating individual and to assure proper performance of the study. However, there are no specific regulations or guidelines for non-Medicinal Investigational Products (non-MIPs) such as allergens, enriched food supplements, and air pollution components. As a consequence, investigators will avoid clinical research and prefer preclinical models or in vitro testing for e.g. toxicology studies. 1) briefly review the current guidelines and regulations for Investigational Medicinal Products; 2) present a standardised approach to ensure the quality and safety of non-MIPs in human in vivo research; and 3) discuss some lessons we have learned. We propose a practical line of approach to compose a clarifying product dossier (PD), comprising the description of the production process, the analysis of the raw and final product, toxicological studies, and a thorough risk-benefit-analysis. This is illustrated by an example from a human in vivo research model to study exposure to air pollutants, by challenging volunteers with a suspension of carbon nanoparticles (the component of ink cartridges for laser printers). With this novel risk-based approach, the members of competent authorities are provided with standardised information on the quality of the product in relation to the safety of the participants, and the scientific goal of the study.

  4. How to achieve safe, high-quality clinical studies with non-Medicinal Investigational Products? A practical guideline by using intra-bronchial carbon nanoparticles as case study

    NARCIS (Netherlands)

    Berger, M; Kooyman, P.J.; Makkee, M.; van der Zee, J.S.; Sterk, P. J.; van Dijk, J.; Kemper, E. M.

    2016-01-01

    Background: Clinical studies investigating medicinal products need to comply with laws concerning good clinical practice (GCP) and good manufacturing practice (GMP) to guarantee the quality and safety of the product, to protect the health of the participating individual and to assure proper

  5. How to achieve safe, high-quality clinical studies with non-Medicinal Investigational Products? A practical guideline by using intra-bronchial carbon nanoparticles as case study

    NARCIS (Netherlands)

    Berger, M.; Kooyman, P. J.; Makkee, M.; van der Zee, J. S.; Sterk, P. J.; van Dijk, J.; Kemper, E. M.

    2016-01-01

    Clinical studies investigating medicinal products need to comply with laws concerning good clinical practice (GCP) and good manufacturing practice (GMP) to guarantee the quality and safety of the product, to protect the health of the participating individual and to assure proper performance of the

  6. Analysis of high-quality modes in open chaotic microcavities

    International Nuclear Information System (INIS)

    Fang, W.; Yamilov, A.; Cao, H.

    2005-01-01

    We present a numerical study of the high-quality modes in two-dimensional dielectric stadium microcavities. Although the classical ray mechanics is fully chaotic in a stadium billiard, all of the high-quality modes show a 'strong scar' around unstable periodic orbits. When the deformation (ratio of the length of the straight segments over the diameter of the half circles) is small, the high-quality modes correspond to whispering-gallery-type trajectories and their quality factors decrease monotonically with increasing deformation. At large deformation, each high-quality mode is associated with multiple unstable periodic orbits. Its quality factor changes nonmonotonically with the deformation, and there exists an optimal deformation for each mode at which its quality factor reaches a local maximum. This unusual behavior is attributed to the interference of waves propagating along different constituent orbits that could minimize light leakage out of the cavity

  7. Physical activity staging distribution: establishing a heuristic using multiple studies.

    Science.gov (United States)

    Nigg, C; Hellsten, L; Norman, G; Braun, L; Breger, R; Burbank, P; Coday, M; Elliot, D; Garber, C; Greaney, M; Keteyian, S; Lees, F; Matthews, C; Moe, E; Resnick, B; Riebe, D; Rossi, J; Toobert, D; Wang, T; Welk, G; Williams, G

    2005-04-01

    The purpose of this study was to identify the population prevalence across the stages of change (SoC) for regular physical activity and to establish the prevalence of people at risk. With support from the National Institutes of Health, the American Heart Association, and the Robert Wood Johnson Foundation, nine Behavior Change Consortium studies with a common physical activity SoC measure agreed to collaborate and share data. The distribution pattern identified in these predominantly reactively recruited studies was Precontemplation (PC) = 5% (+/- 10), Contemplation (C) = 10% (+/- 10), Preparation (P) = 40% (+/- 10), Action = 10% (+/- 10), and Maintenance = 35% (+/- 10). With reactively recruited studies, it can be anticipated that there will be a higher percentage of the sample that is ready to change and a greater percentage of currently active people compared to random representative samples. The at-risk stage distribution (i.e., those not at criteria or PC, C, and P) was approximately 10% PC, 20% C, and 70% P in specific samples and approximately 20% PC, 10% C, and 70% P in the clinical samples. Knowing SoC heuristics can inform public health practitioners and policymakers about the population's motivation for physical activity, help track changes over time, and assist in the allocation of resources.

  8. Feasibility Study Analysis of Establishing Archery Sports Special Place

    Science.gov (United States)

    Tarigan, U. P. P.; Mardhatillah, A.; Budiman, I.; Sembiring, A. C.; Ramadhan, M. S.

    2018-04-01

    This study essentially discusses the basic concepts related to the decision and process of selecting a sports archery business project in order to provide economic and social benefits over time. Archery sports is a sport that requires special skills, both accuracy, coordination mental training and improves the physical condition of the prime. In Medan, it's still a bit of practice archery, but many people love this sport. From the data collected, there are three locations where archery in the city of the field of the Sunggal Knights is located at Jl Tunggul Hitam no.1A, Kec. Medan Sunggal, Avros Educational Park Aval address at Avros Street No.60 Medan, and the Knights of Johor Archery Club which is located at Jl. The work of Darma Gg. Ujung Family, Medan Johor. Therefore a feasibility study was undertaken in establishing an archery sports place in the field. The aspects to be considered in making feasibility studies are market and marketing aspects, technical and equipment aspects, management aspects, legal aspects, economic and social aspects, and financial aspects. Financial analysis using own capital got Payback Period 3 years 5,8 months, Net Present Value Rp 11.684.026 and obtained Internal Rate of Return of 17%.

  9. A Study of WLAN Campus in an Educational Establishment

    Directory of Open Access Journals (Sweden)

    Taghareed Abdul-Hameed

    2009-10-01

    Full Text Available the main aim of campus network is to efficiently separate, share and access knowledge among its users. The big demand of such systems of distributed knowledge networks is to be able to handle advanced applications which are the end-user requirements. The main goal of this study is to assess the ability of WLAN campus to dealing with applications request of end users in education establishments and network achievement under different conditions of operation. The study has been conducted in two stages: the first stage was accomplished by conducting a survey, using the Student Village network at Anglia Ruskin University as a case study; the main aim was to determine end-use requirements, gather information about the nature applications running by users and get a view about the likely future applications. The second stage was achieved by conducting experiments to evaluate the WLAN campus network performance under various different scenarios: impact of handover from Access Point (AP to another AP on end-user link performance, network performance in different usage time and network performance in different weather conditions.

  10. A study on the establishment of national nuclear foreign policy

    International Nuclear Information System (INIS)

    Oh, Keun Bae; Ham, Chul Hoon; Lee, Kwang Suk; Cho, Il Hoon; Lee, Byung Wook; Lee, Jae Sung; Lee, Byung Woon; Choi, Yung Lok; Koh, Han Suk

    1994-12-01

    This study is composed mainly of the current status of international non-proliferation, the NPT extension, IAEA Status, the circumstances of nuclear export control system, and the Vienna convention and London convention. The recent circumstances of the NPT have been analyzed. We established counter measures and strategies on the NPT extension conference. After reviewing the international export control system of NSG members, we suggested the factors which should be involved in the nuclear export control system. Also, U.S. systems on retransferring were intensively reviewed. In connection with the challenges coped with by the IAEA, several agenda have been reviewed and analyzed: the financing status of the Agency; the program 93+2 for the strengthening of effectiveness and improving of efficiency in the safeguards system. In connection with the amendment work of the Vienna Convention, we studied the major contents of four proposals which were suggested. In the case of the London Convention, the causes of maritime pollution and the kinds of sea dumping material were investigated. 3 figs, 13 tabs, 66 refs. (Author)

  11. A study on the establishment of national nuclear foreign policy

    Energy Technology Data Exchange (ETDEWEB)

    Oh, Keun Bae; Ham, Chul Hoon; Lee, Kwang Suk; Cho, Il Hoon; Lee, Byung Wook; Lee, Jae Sung; Lee, Byung Woon; Choi, Yung Lok; Koh, Han Suk [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

    1994-12-01

    This study is composed mainly of the current status of international non-proliferation, the NPT extension, IAEA Status, the circumstances of nuclear export control system, and the Vienna convention and London convention. The recent circumstances of the NPT have been analyzed. We established counter measures and strategies on the NPT extension conference. After reviewing the international export control system of NSG members, we suggested the factors which should be involved in the nuclear export control system. Also, U.S. systems on retransferring were intensively reviewed. In connection with the challenges coped with by the IAEA, several agenda have been reviewed and analyzed: the financing status of the Agency; the program 93+2 for the strengthening of effectiveness and improving of efficiency in the safeguards system. In connection with the amendment work of the Vienna Convention, we studied the major contents of four proposals which were suggested. In the case of the London Convention, the causes of maritime pollution and the kinds of sea dumping material were investigated. 3 figs, 13 tabs, 66 refs. (Author).

  12. A study on the establishment of severe accident experimental facility

    International Nuclear Information System (INIS)

    Yoo, Kun Joong; Kim, Sang Baek; Kim, In Sik; Nho, Ki Man; Bark, Rae Joon; Park, Chun Kyeong; Sim, Seok Koo; Lee, Seong Jae; Chung, Moon Ki; Cho, Yeong Ro; Chun, Shee Yeong

    1994-07-01

    Significant progress has been achieved during this year of the project. Planned DCH experiments on the sensitivity of the cavity geometry factors and the cavity capture volume effects were performed using the HPME facility for Kori-1/2 and YGN-3/4 cavity scale models. The Crust Formation Test Facility has been completed. Preliminary calculations were performed to predict test results. The experiments of the crust formation on the simulant and its heat transfer characteristic were performed to investigate the effects of coolant injection methods, bottom heating boundary surface temperatures, coolant temperatures and coolant flow rates. The design of the FCI Test Facility has been completed and the procurement of the materials is in progress. Also, the steam condensation experiment on the vertical containment walls and the research on the development of measuring techniques of the particle sizes and velocities are in progress as planned. Through international research collaboration with USNRC and CEA Cadarache, information of the experimental research on the severe fuel damage has been gathered and analyzed. Preliminary planning of the second phase tests has been launched this year. This study proposes the scope of the second phase and the strategy to implement the proposed second phase experimental program. This study also proposes a strategy to establish building blocks and infrastructure for the severe accident research in Korea. (Author)

  13. Study on Establishing Standard Administrative Report Guidelines for KAERI

    Energy Technology Data Exchange (ETDEWEB)

    Koo, Hwang Duk; Cho, Woo Sung; Lee, Bong Jae

    2012-12-15

    Ο The main purpose of administrative report of an organization is to deliver a critical mind about surrounding circumstance and rational alternatives to a final decision maker Ο An established report system with unified formality and systematic concept playes critical role to make right decision and efficient review about pending issues Ο By understanding current situation of report system using in KAERI and analysing examples of other organization, we established specific administrative report writing guideline for KAERI Ο We expect efficient communication and increasing productivity from the guideline by establishing and diffusing administrative report common writing guideline reflecting longstanding administrative experience and know-how of a specialized committeeman of KAERI.

  14. Study on Establishing Standard Administrative Report Guidelines for KAERI

    International Nuclear Information System (INIS)

    Koo, Hwang Duk; Cho, Woo Sung; Lee, Bong Jae

    2012-12-01

    Ο The main purpose of administrative report of an organization is to deliver a critical mind about surrounding circumstance and rational alternatives to a final decision maker Ο An established report system with unified formality and systematic concept playes critical role to make right decision and efficient review about pending issues Ο By understanding current situation of report system using in KAERI and analysing examples of other organization, we established specific administrative report writing guideline for KAERI Ο We expect efficient communication and increasing productivity from the guideline by establishing and diffusing administrative report common writing guideline reflecting longstanding administrative experience and know-how of a specialized committeeman of KAERI

  15. Stewardship matters: Case studies in establishment success of urban trees

    Science.gov (United States)

    Lara A. Roman; Lindsey A. Walker; Catherine M. Martineau; David J. Muffly; Susan A. MacQueen; Winnie Harris

    2015-01-01

    Urban tree planting initiatives aim to provide ecosystem services that materialize decades after planting, therefore understanding tree survival and growth is essential to evaluating planting program performance. Tree mortality is relatively high during the establishment phase, the first few years after planting. Qualitative assessments of programs with particularly...

  16. Establishing Visual Category Boundaries between Objects: A PET Study

    Science.gov (United States)

    Saumier, Daniel; Chertkow, Howard; Arguin, Martin; Whatmough, Cristine

    2005-01-01

    Individuals with Alzheimer's disease (AD) often have problems in recognizing common objects. This visual agnosia may stem from difficulties in establishing appropriate visual boundaries between visually similar objects. In support of this hypothesis, Saumier, Arguin, Chertkow, and Renfrew (2001) showed that AD subjects have difficulties in…

  17. High-quality uniform dry transfer of graphene to polymers.

    Science.gov (United States)

    Lock, Evgeniya H; Baraket, Mira; Laskoski, Matthew; Mulvaney, Shawn P; Lee, Woo K; Sheehan, Paul E; Hines, Daniel R; Robinson, Jeremy T; Tosado, Jacob; Fuhrer, Michael S; Hernández, Sandra C; Walton, Scott G

    2012-01-11

    In this paper we demonstrate high-quality, uniform dry transfer of graphene grown by chemical vapor deposition on copper foil to polystyrene. The dry transfer exploits an azide linker molecule to establish a covalent bond to graphene and to generate greater graphene-polymer adhesion compared to that of the graphene-metal foil. Thus, this transfer approach provides a novel alternative route for graphene transfer, which allows for the metal foils to be reused. © 2011 American Chemical Society

  18. Are bidirectional associations of obesity and depression already apparent in childhood and adolescence as based on high-quality studies? A systematic review.

    Science.gov (United States)

    Mühlig, Y; Antel, J; Föcker, M; Hebebrand, J

    2016-03-01

    Our aim was to evaluate bidirectional associations of obesity and depression in cross-sectional and longitudinal studies with initial assessments in childhood or adolescence. The clarification of these relationships may support the development of innovative interventions, e.g. based on nutrition and mental health. A systematic literature search was conducted in MEDLINE. Main inclusion criteria were (i) assessment of subjects obesity and depression. Three out of eight longitudinal studies reported associations between obesity and subsequent depression in female children and adolescents only, and three out of nine studies obtained evidence in favour of the other direction with two studies revealing significant results only for female and one only for male children and adolescents. Evidence is mixed, and secure conclusions are hampered by the methodological variance of the included studies. Relationships are seemingly more readily detectable in female children adolescents and in the cross-sectional compared with the longitudinal analyses. Possibly, the joint development of obesity and depression in predisposed subjects accounts for the latter discrepancy. © 2015 World Obesity.

  19. Longitudinal study of prognostic factors in established periodontitis patients.

    Science.gov (United States)

    Machtei, E E; Dunford, R; Hausmann, E; Grossi, S G; Powell, J; Cummins, D; Zambon, J J; Genco, R J

    1997-02-01

    Numerous indicators for disease progression have been described in the last decade. The purpose of this study was to examine, longitudinally, a large battery of clinical, microbiological, and immunological indicators, to try to determine whether the presence of one or a combination of these parameters at baseline, would correlate positively with increased attachment and or bone loss (true prognostic factors). Following initial screening, 79 patients with established periodontitis were monitored longitudinally for one year. Whole mouth clinical measurements, plaque gingival and calculus indices, together with pocket depth and attachment level measurements, were repeated every three months. Full mouth radiographic survey, performed at baseline and 12 months, served to determine changes in crestal bone height using an image enhancement technique. Subgingival plaque samples were taken at baseline and every 3 months. Immunofluorescence assays were performed for the a battery of target microorganisms. Serum and GCF samples for IgG subclasses analysis were obtained at each visit and assayed using ELISA techniques. Likewise blood, samples were also drawn at each visit for a quantitative analysis of serum cotinine level. The overall mean attachment loss (AL) and bone loss (BL) were almost identical (0.159 mm and 0.164 mm, respectively). Individual patients variation was large (-0.733 to +1.004 mm). An overall 6.89% of sites were active; individual patients' means ranged from 0-28.9%. Mean pocket depth (PD) showed minimal change over the study period (-0.033 mm) thus suggesting that most if not all the AL was accompained by concomitant gingival recession. Smokers exhibited greater AL and radiographic BL compared to non-smokers. Likewise, patients' cotinine level showed direct correlation with outcomes of progressive periodontal breakdown. Past severity of periodontal involvement, as reflected in the patients baseline PD, AL and crestal bone height, showed good correlation

  20. Income and Access to Higher Education: Are High Quality Universities Becoming More or Less Elite? A Longitudinal Case Study of Admissions at UW-Madison

    Directory of Open Access Journals (Sweden)

    Sara E. Dahill-Brown

    2016-04-01

    Full Text Available Has access to selective postsecondary schools expanded or contracted? Evaluating this question has proven a difficult task because data are limited, particularly with regard to family income. We complement previous work and provide a replicable model of institutional analysis. This paper presents a detailed, quantitative assessment of admissions at the University of Wisconsin-Madison, an elite flagship public university—the type that is supposed to offer excellent opportunities to students from all backgrounds. We use an innovative measure of family income to compare applicant, admissions, and enrollment trends for low-income and minority students from 1972 to 2007. The unique aspects of this study include the more reliable measure of income and the ability to look at the full process from applications, admissions, and matriculations (demand and supply, not generally available in national datasets.

  1. Improving access to high-quality primary care for socioeconomically disadvantaged older people in rural areas: a mixed method study protocol.

    Science.gov (United States)

    Ford, John A; Jones, Andrew P; Wong, Geoff; Clark, Allan B; Porter, Tom; Shakespeare, Tom; Swart, Ann Marie; Steel, Nicholas

    2015-09-18

    The UK has an ageing population, especially in rural areas, where deprivation is high among older people. Previous research has identified this group as at high risk of poor access to healthcare. The aim of this study is to generate a theory of how socioeconomically disadvantaged older people from rural areas access primary care, to develop an intervention based on this theory and test it in a feasibility trial. On the basis of the MRC Framework for Developing and Evaluating Complex Interventions, three methods will be used to generate the theory. First, a realist review will elucidate the patient pathway based on existing literature. Second, an analysis of the English Longitudinal Study of Ageing will be completed using structural equation modelling. Third, 15 semistructured interviews will be undertaken with patients and four focus groups with health professionals. A triangulation protocol will be used to allow each of these methods to inform and be informed by each other, and to integrate data into one overall realist theory. Based on this theory, an intervention will be developed in discussion with stakeholders to ensure that the intervention is feasible and practical. The intervention will be tested within a feasibility trial, the design of which will depend on the intervention. Lessons from the feasibility trial will be used to refine the intervention and gather the information needed for a definitive trial. Ethics approval from the regional ethics committee has been granted for the focus groups with health professionals and interviews with patients. Ethics approval will be sought for the feasibility trial after the intervention has been designed. Findings will be disseminated to the key stakeholders involved in intervention development, to researchers, clinicians and health planners through peer-reviewed journal articles and conference publications, and locally through a dissemination event. Published by the BMJ Publishing Group Limited. For permission to

  2. Postoperative Complications of Laparoscopic Total Gastrectomy versus Open Total Gastrectomy for Gastric Cancer in a Meta-Analysis of High-Quality Case-Controlled Studies

    Directory of Open Access Journals (Sweden)

    Mikito Inokuchi

    2016-01-01

    Full Text Available Background. Some meta-analyses of case-controlled studies (CCSs have shown that laparoscopic or laparoscopy-assisted total gastrectomy (LTG had some short-term advantages over open total gastrectomy (OTG. However, postoperative complications differed somewhat among the meta-analyses, and some CCSs included in the meta-analyses had mismatched factors between LTG and OTG. Methods. CCSs comparing postoperative complications between LTG and OTG were identified in PubMed and Embase. Studies matched for patients’ status, tumor stage, and the extents of lymph-node dissection were included. Outcomes of interest, such as anastomotic, other intra-abdominal, wound, and pulmonary complications, were evaluated in a meta-analysis performed using Review Manager version 5.3 software. Result. This meta-analysis included a total of 2,560 patients (LTG, 1,073 patients; OTG, 1,487 patients from 15 CCSs. Wound complications were significantly less frequent in LTG than in OTG (n = 2,430; odds ratio [OR] 0.30, 95% confidence interval [CI] 0.29–0.85, P=0.01, I2 = 0%, and OR 0.46, 95% CI 0.17–0.52, P<0.0001, I2 = 0%. However, the incidence of anastomotic complications was slightly but not significantly higher in LTG than in OTG (n = 2,560; OR 1.44, 95% CI 0.96–2.16, P=0.08, I2 = 0%. Conclusion. LTG was associated with a lower incidence of wound-related postoperative complications than was OTG in this meta-analysis of CCSs; however, some concern remains about anastomotic problems associated with LTG.

  3. Assessing the Value of High-Quality Care for Work-Associated Carpal Tunnel Syndrome in a Large Integrated Health Care System: Study Design.

    Science.gov (United States)

    Conlon, Craig; Asch, Steven; Hanson, Mark; Avins, Andrew; Levitan, Barbara; Roth, Carol; Robbins, Michael; Dworsky, Michael; Seabury, Seth; Nuckols, Teryl

    2016-01-01

    Little is known about quality of care for occupational health disorders, although it may affect worker health and workers' compensation costs. Carpal tunnel syndrome (CTS) is a common work-associated condition that causes substantial disability. To describe the design of a study that is assessing quality of care for work-associated CTS and associations with clinical outcomes and costs. Prospective observational study of 477 individuals with new workers' compensation claims for CTS without acute trauma who were treated at 30 occupational health clinics from 2011 to 2013 and followed for 18 months. Timing of key clinical events, adherence to 45 quality measures, changes in scores on the Boston Carpal Tunnel Questionnaire and 12-item Short Form Health Survey Version 2 (SF-12v2), and costs associated with medical care and disability. Two hundred sixty-seven subjects (56%) received a diagnosis of CTS and had claims filed around the first visit to occupational health, 104 (22%) received a diagnosis before that visit and claim, and 98 (21%) received a diagnosis or had claims filed after that visit. One hundred seventy-eight (37%) subjects had time off work, which started around the time of surgery in 147 (83%) cases and lasted a median of 41 days (interquartile range = 42 days). The timing of diagnosis varied, but time off work was generally short and related to surgery. If associations of quality of care with key medical, economic, and quality-of-life outcomes are identified for work-associated CTS, systematic efforts to evaluate and improve quality of medical care for this condition are warranted.

  4. Does surgical site infection after Caesarean section in Polish hospitals reflect high-quality patient care or poor postdischarge surveillance? Results from a 3-year multicenter study.

    Science.gov (United States)

    Różańska, Anna; Jarynowski, Andrzej; Kopeć-Godlewska, Katarzyna; Wójkowska-Mach, Jadwiga; Misiewska-Kaczur, Agnieszka; Lech, Marzena; Rozwadowska, Małgorzata; Karwacka, Marlena; Liberda, Joanna; Domańska, Joanna

    2018-01-01

    Caesarean sections (CSs) are associated with a high infection risk. Surgical site infection (SSI) incidence is among the markers of effectiveness of infection prevention efforts. The aim of this study was to analyze risk factors for SSI, incidence, and microbiology in patients who underwent CS. The study was conducted during 2013-2015 using active infection surveillance in 5 Polish hospitals according to the European Centre for Disease Prevention and Control surveillance network known as HAI-Net. For each procedure, the following data were registered: age, American Society of Anesthesiologists score, procedure time, elective or emergency procedure, use of perioperative antibiotic prophylaxis, microbiology, the treatment used, and other information. SSI incidence was 0.5% and significant differences were noted among hospitals (between 0.1% and 1.8%), for different American Society of Anesthesiologists scales (between 0.2% and 4.8%) and different values of standardized SSI risk index (between 0.0% and 0.8%). In 3.1% of procedures, with no antibiotic prophylaxis, SSI risk was significantly higher. Deep infections dominated: 61.5% with superficial infections in only approximately 30% of cases and 2.6% of infections were detected postdischarge without readmissions. Results showed high incidence of SSI in Poland without perioperative antibiotic prophylaxis, and secondly, ineffective surveillance according to CS status, considering outpatient obstetric care. Without postdischarge surveillance, it is not possible to recognize the epidemiologic situation, and further, to set priorities and needs when it comes to infection prophylaxis, especially because such low incidence may indicate no need for improvement in infection control. Copyright © 2018 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.

  5. A case study on toxicological aspects of the pest and disease control in the production of the high-quality raspberry (Rubus idaeus L.).

    Science.gov (United States)

    Sadło, Stanisław; Szpyrka, Ewa; Piechowicz, Bartosz; Grodzicki, Przemysław

    2015-01-01

    The field studies on the residue levels of the fungicides and insecticides used in commercial raspberry (Rubus idaeus L.) plantation have been performed. Starting on the first day of harvesting (on June 19), 20 laboratory samples of fruit, 10 laboratory samples of leaves and 4 samples of soil were analyzed and the residue levels were compared to the Maximum Residue Limits (MRL) and Acceptable Daily Intakes (ADI). All analyses were carried out using extraction method and gas chromatography technique. Esfenwalerate (Sumi-alpha 050 EC) and beta-cyfluthrin (Bulldock 025 EC), the insecticides belonging to the group of synthetic pyrethroids, were not found in harvested ripe fruits, while cypermethrin residues (Cyperkill 25 EC) applied on May 24, 25 days later was still found on low levels in fruits (0.026 mg kg(-1)) and in leaves (2.58 mg kg(-1)). In turn, residues of chlorpyrifos (Dursban 480 EC), applied to the soil on May 15 against the cockchafers Melolontha melolontha and Otiorhynchus sp., were found at the level 0.004 mg kg(-1). The content of pesticides in ripe fruits depended mainly on the dose and on the time that has elapsed from the date of their application and were as follows: boscalid -0.950, pyrimethanil -0.917, pyraclostrobin -0.253 cypermethrin -0.026 and chlorpyrifos -0.004 mg kg(-1) while in leaves: boscalid -30.64, pyrimethanil -8.13, pyraclostrobin -15.82, cypermethrin -2.58 and chlorpyrifos -0.15 mg kg(-1). The highest average daily intake was in the case of boscalid, and in fruits and leaves reached the levels 0.205 and 6.63, in total 0.33% and 12.18% of ADI, respectively.

  6. Multiband superconductivity in heavy fermion compound CePt3Si without inversion symmetry. An NMR study on a high-quality single crystal

    International Nuclear Information System (INIS)

    Mukuda, Hidekazu; Nishide, Sachihiro; Harada, Atsushi

    2009-01-01

    We report on novel superconducting characteristics of the heavy fermion (HF) superconductor CePt 3 Si without inversion symmetry through 195 Pt-NMR study on a single crystal with T c =0.46 K that is lower than T c - 0.75 K for polycrystals. We show that the intrinsic superconducting characteristics inherent to CePt 3 Si can be understood in terms of the unconventional strong-coupling state with a line-node gap below T c =0.46 K. The mystery about the sample dependence of T c is explained by the fact that more or less polycrystals and single crystals inevitably contain some disordered domains, which exhibit a conventional BCS s-wave superconductivity (SC) below 0.8 K. In contrast, the Neel temperature T N - 2.2 K is present regardless of the quality of samples, revealing that the Fermi surface responsible for SC differ from that for the antiferromagnetic order. These unusual characteristics of CePt 3 Si can be also described by a multiband model; in the homogeneous domains, the coherent HF bands are responsible for the unconventional SC, whereas in the disordered domains the conduction bands existing commonly in LaPt 3 Si may be responsible for the conventional s-wave SC. We remark that some impurity scatterings in the disordered domains break up the 4f-electrons-derived coherent bands but not others. In this context, the small peak in 1/T 1 just below T c reported before [Yogi et al. (2004)] is not due to a two-component order parameter composed of spin-singlet and spin-triplet Cooper pairing states, but due to the contamination of the disorder domains which are in the s-wave SC state. (author)

  7. Establishing a greenhouse gas inventory and reduction goal: case study

    International Nuclear Information System (INIS)

    Carli, G.A.; Richardson, S.L.

    2009-01-01

    'Full text:' Since 1976, Conestoga-Rovers & Associates (CRA) has grown from a small, regional engineering company, to one of the world's most sought-after, multi-disciplinary engineering and consulting firms with over 90 offices and more than 2,700 people working on projects worldwide. CRA is committed to helping its clients meet or exceed their environmental performance goals while achieving its own sustainability objectives. CRA is continuously striving to implement social and environmental performance improvements in each and every work place where CRA conducts business. CRA's Corporate Sustainability, Social Responsibility, and Environmental Policy reflects this commitment. CRA is working to reduce its environmental footprint and invest in the communities in which we live and conduct business. CRA undertook a corporate-wide greenhouse gas (GHG) inventory and set aggressive GHG reduction goals. This presentation provides an overview of the steps CRA has taken to quantify corporate GHG emissions, including establishing boundary conditions, data collection activities, calculation of GHG emissions, and development of and inventory management plant consistent with the U.S. EPA Climate Leaders program. The presentation discusses the primary challenges addressed in developing a GHG inventory for multiple facilities located throughout North America, including obtaining verifiable data, addressing corporate travel, and communicating climate change goals within the organization. The presentation concludes with an overview of the key considerations necessary to establish a credible reduction goal. (author)

  8. Fabrication of high-quality brazed joints

    International Nuclear Information System (INIS)

    Orlov, A.V.

    1980-01-01

    Problem of ensuring of joint high-quality when brazing different parts in power engineering is considered. To obtain high-quality joints it is necessary to correctly design brazed joint and to choose a gap width, overlap length and fillet radius; to clean up carefully the surfaces to be brazed and fix them properly one relative to another; to apply a solder so as to provide its flowing into the gap and sticking in it; to exactly regulate thermal conditions of brazing. High quality and reliability of brazed joints are ensured by the application of solders based on noble metals, and cheap solders based on nickel, manganese and copper. Joints brazed with nickel base solders may operate at temperatures as high as 888 deg C

  9. Socio-technological study for establishing comprehensive nuclear safety system

    International Nuclear Information System (INIS)

    Furuta, Kazuo; Kanno, Taro; Yagi, Ekou; Shuto, Yuki

    2003-01-01

    This paper presents an overview and preliminary results of a research project on social-technology for nuclear safety, which started in October 2001. In particular, emergency response preparedness against nuclear disaster and consensus development will be discussed. The architecture of an emergency response simulator will be given, which is for assessing design of disaster prevention systems. A conceptual model of evacuation behavior of a resident has been constructed from analysis of past disaster cases. As for consensus development, deliberation spaces of actual committee meetings were constructed by analyzing transcripts of the meetings based on an opinion schema. A model of consensus development process has been proposed from the traces of participants' opinions over the deliberation spaces. Such a socio-technological approach will be useful not only for nuclear safety but also for safety of non-nuclear domains and human activities of a high hazard potential; it is expected to contribute to establishing risk-aware society of the future. (author)

  10. Feasibility study to establish a new value chain

    DEFF Research Database (Denmark)

    Ingrid Herman, Marie; Thai, Thi Minh

    Since the 90s value chain (VC) approaches have received considerable attention by governments and development agencies for poverty reduction and strengthening the private sector. VC analysis has been used for developing intervention strategies to upgrade existing or to establish new VCs. Despite...... and starting to valorize New Caledonian horticulture on international markets. Once goals were understood, four interrelated analyses were conducted continuously: enabling environment, productivity, structuration, and feasibility analysis. In the enabling environment, analysis of market, institution......, and infrastructure highlighted high demands for the species Sticherus flabellatus, well-maintained roads, and legal voids concerning wild harvesting. The productivity analysis on resource availability and harvesting potential pointed out randomness of the resource and its quality, and the rarity of Sticherus...

  11. Next Generation High Quality Videoconferencing Service for the LHC

    CERN Multimedia

    CERN. Geneva

    2012-01-01

    In recent times, we have witnessed an explosion of video initiatives in the industry worldwide. Several advancements in video technology are currently improving the way we interact and collaborate. These advancements are forcing tendencies and overall experiences: any device in any network can be used to collaborate, in most cases with an overall high quality. To cope with this technology progresses, CERN IT Department has taken the leading role to establish strategies and directions to improve the user experience in remote dispersed meetings and remote collaboration at large in the worldwide LHC communities. Due to the high rate of dispersion in the LHC user communities, these are critically dependent of videoconferencing technology, with a need of robustness and high quality for the best possible user experience. We will present an analysis of the factors that influenced the technical and strategic choices to improve the reliability, efficiency and overall quality of the LHC remote sessions. In particular, ...

  12. Producing high-quality slash pine seeds

    Science.gov (United States)

    James Barnett; Sue Varela

    2003-01-01

    Slash pine is a desirable species. It serves many purposes and is well adapted to poorly drained flatwoods and seasonally flooded areas along the lower Coastal Plain of the Southeastern US. The use of high-quality seeds has been shown to produce uniform seedlings for outplanting, which is key to silvicultural success along the Coastal Plain and elsewhere. We present...

  13. Establishment of frame image in dynamic function renal studies

    International Nuclear Information System (INIS)

    Guedes, Germano P.; Brunetto, Sergio Q.

    1996-01-01

    Statistical procedures applied to a set of images of renal function study are described to define a region of interest (ROI) on the kidneys's contours. The kidneys geometry is considered to adapt to the emitting area in every frames

  14. The possibility of establishing a doctoral programme in archive studies

    Directory of Open Access Journals (Sweden)

    Waldemar Chorążyczewski

    2013-03-01

    Full Text Available Doctor studies have been included into formalised education system as a third cycle studies. In the light of ministerial regulations, the archive studies doctoral program ought to encompass classes on archives, methodology of sciences, didactics of higher education studies, the social role of an academic, conducting student internship. Does this mean, that a doctoral seminar in archive studies is excessive? On the contrary, the seminar seems to be the best place to bequeath knowledge and skills on methodology and the proper attitude of a scholar, in awareness of his or her role in the society.By these standards, the seminar should be understood not solely as a place to forge doctoral theses, but also as a site on which to conduct discussion with one's academic authorities and advisors and guest experts; it also should be the key class, taking up the most of the timetable. The validity of preparing an archivist for the role of a university teacher has been questioned.Both the profile of the doctor courses and observation of their effectiveness has led us to believe informal seminar to be the better way of doctoral education for archive students. Perhaps though, the kind of steps, that must be taken if doctor course on archive studies was to be created, is worth considering. Is there a chance, and, is it worth striving for the archive studies to be an independent department? It would not only mean opening doctor programmes, but also the right confer a PhD degree in Humanities, on the subject of archive studies, and not history, as it has hitherto been done. The archive studies have definite research subject, range and methodology. What is noticeable is a kind of archival sensitivity, that allows for all the users and all the purposes for using the resources to be on equal rights. Archive studies have matured, and it is ready to become an independent academic discipline. Thereby, it can be expected, that at last, it's maturity will be put to good

  15. Establishing a mathematical Lesson Study culture in Danish teacher education

    DEFF Research Database (Denmark)

    Skott, Charlotte Krog; Østergaard, Camilla Hellsten

    Bridging theory and practice is a general challenge in mathematics teacher education. Research shows that Lesson Study (LS) is an effective way for prospective mathematics teachers to build relations between course work and field experiences......Bridging theory and practice is a general challenge in mathematics teacher education. Research shows that Lesson Study (LS) is an effective way for prospective mathematics teachers to build relations between course work and field experiences...

  16. Establishing a framework for studying the emerging cislunar economy

    Science.gov (United States)

    Entrena Utrilla, Carlos Manuel

    2017-12-01

    Recent developments from the New Space industry have seen the appearance of a number of new companies interested in the creation of a self-sustained economy in cislunar space. Industries such as asteroid mining, Moon mining, and on-orbit manufacturing require the existence of a developed economy in space for the business cases to close in the long term, without the need to have the government as a permanent anchor customer. However, most studies and business plans do not consider the global picture of the cislunar economy, and only work with Earth-based activities when evaluating possible customers and competition. This work aims to set the framework for the study of the cislunar economy as a whole by identifying the market verticals that will form the basis of the economic activities in cislunar space, focusing on activities that create value in space for space. The prospective cislunar market verticals are identified based on a comprehensive review of current space activities and of proposed future business cases. This framework can be expanded in the future with evaluations of market sizes and relationships between verticals to inform business plans and investment decisions. The study was performed during the first two months in the summer of 2016 as part of the author's internship at NASA's Space Portal Office to complete the International Space University Master of Space Studies.

  17. Establishment of an equivalence acceptance criterion for accelerated stability studies.

    Science.gov (United States)

    Burdick, Richard K; Sidor, Leslie

    2013-01-01

    In this article, the use of statistical equivalence testing for providing evidence of process comparability in an accelerated stability study is advocated over the use of a test of differences. The objective of such a study is to demonstrate comparability by showing that the stability profiles under nonrecommended storage conditions of two processes are equivalent. Because it is difficult at accelerated conditions to find a direct link to product specifications, and hence product safety and efficacy, an equivalence acceptance criterion is proposed that is based on the statistical concept of effect size. As with all statistical tests of equivalence, it is important to collect input from appropriate subject-matter experts when defining the acceptance criterion.

  18. THE CONTRIBUTION OF ESTABLISHING HOLOCAUST STUDY IN ALBANIA

    Directory of Open Access Journals (Sweden)

    Efrat KEDEM-TAHAR

    2014-11-01

    Full Text Available The aim of this article is to contribute a practical study model based on long term, deep, mainly historical studies about the Holocaust inAlbania. A similar model has already existed forthe eight years in Bucharest, Romania. Based on its advantages and the needs in Albania I built a new model. The article describes the relevanthistorical backgroundand raised the humanistic questions that have interested and challenged many historians over the last 20 years.The article is based on theoretical methods from other fields and integrates them into the original model. The model is divided into two parts that are interdependent. The conclusion and discussion summarize all the factors in order to convince the Albanian Ministry of Education and University of Tirana to adopt its idea.

  19. Study to establish cost projections for production of Redox chemicals

    Science.gov (United States)

    Walther, J. F.; Greco, C. C.; Rusinko, R. N.; Wadsworth, A. L., III

    1982-01-01

    A cost study of four proposed manufacturing processes for redox chemicals for the NASA REDOX Energy Storage System yielded favorable selling prices in the range $0.99 to $1.91/kg of chromic chloride, anhydrous basis, including ferrous chloride. The prices corresponded to specific energy storage costs from under $9 to $17/kWh. A refined and expanded cost analysis of the most favored process yielded a price estimate corresponding to a storage cost of $11/kWh. The findings supported the potential economic viability of the NASA REDOX system.

  20. [Establishing and hosting an Institute for Fusion Studies

    International Nuclear Information System (INIS)

    Baldwin, D.E.

    1989-07-01

    Significant progress was made during the past year in carrying out theoretical investigations pursuant to the scientific mission of the Institute. These achievements may be approximately classified in terms of the following categories (often with considerable overlap): sawteeth and MHD studies, turbulence theory and plasma transport, computational plasma physics, stability theory, mathematical physics, advanced ideas, and space plasma physics-related problems. An overview of this work is contained in this report. Detailed summaries of IFS Reports written during FY 89 are given in abstract form

  1. Establishment of tritium dating facility for hydrological studies in PNRI

    International Nuclear Information System (INIS)

    Mendoza, Norman; Sucgang, Raymond; Castaneda, Soledad

    2009-01-01

    The release of excess tritium ( 3 H) into the atmosphere from nuclear weapons tests conducted between 1952 and 1963 'tagged' rain water, and thereby all surface waters with 3 HHO. Measurement of 3 H concentrations in rain, surface water and groundwater is useful index of vulnerability and sustainability of the aquifer to pollution and human exploitation. These determinations are currently being used in the characterization of different environments and in pollution studies, in the framework of research projects, international collaborations and services. Liquid scintillation counting (LSC) was the method of choice for the evaluation of the tritium concentrations in precipitation, groundwater and surface water samples. Prior to counting process, the samples are enriched in tritium by an electrolysis procedure to improve the overall detection limit. Low-level hydrological water samples go through an electrolytic enrichment step, in which tritium concentrations are increased to about seventy-fold through volume reduction. The amount of tritium in water is expressed in tritium units (TU). Water samples taken from selected areas of Bulacan province within the period of 2007 and 2008 were analyzed as part of the current hydrological studies being done by our group in PNRI. The typical tritium values for the rain water, surface water, and groundwater were found to be 1.20±0.11 TU, 1.12±0.11 TU, and 0.40±0.07, respectively. Procedures are now available in our laboratory for measurement of tritium in water samples of different water types. (author)

  2. Issues in Establishing Climate Sensitivity in Recent Studies

    Directory of Open Access Journals (Sweden)

    John T. Fasullo

    2011-09-01

    Full Text Available Numerous attempts have been made to constrain climate sensitivity with observations [1-10] (with [6] as LC09, [8] as SB11. While all of these attempts contain various caveats and sources of uncertainty, some efforts have been shown to contain major errors and are demonstrably incorrect. For example, multiple studies [11-13] separately addressed weaknesses in LC09 [6]. The work of Trenberth et al. [13], for instance, demonstrated a basic lack of robustness in the LC09 method that fundamentally undermined their results. Minor changes in that study’s subjective assumptions yielded major changes in its main conclusions. Moreover, Trenberth et al. [13] criticized the interpretation of El Niño-Southern Oscillation (ENSO as an analogue for exploring the forced response of the climate system. In addition, as many cloud variations on monthly time scales result from internal atmospheric variability, such as the Madden-Julian Oscillation, cloud variability is not a deterministic response to surface temperatures. Nevertheless, many of the problems in LC09 [6] have been perpetuated, and Dessler [10] has pointed out similar issues with two more recent such attempts [7,8]. Here we briefly summarize more generally some of the pitfalls and issues involved in developing observational constraints on climate feedbacks. [...

  3. High-quality compressive ghost imaging

    Science.gov (United States)

    Huang, Heyan; Zhou, Cheng; Tian, Tian; Liu, Dongqi; Song, Lijun

    2018-04-01

    We propose a high-quality compressive ghost imaging method based on projected Landweber regularization and guided filter, which effectively reduce the undersampling noise and improve the resolution. In our scheme, the original object is reconstructed by decomposing of regularization and denoising steps instead of solving a minimization problem in compressive reconstruction process. The simulation and experimental results show that our method can obtain high ghost imaging quality in terms of PSNR and visual observation.

  4. High quality transportation fuels from renewable feedstock

    Energy Technology Data Exchange (ETDEWEB)

    Lindfors, Lars Peter

    2010-09-15

    Hydrotreating of vegetable oils is novel process for producing high quality renewable diesel. Hydrotreated vegetable oils (HVO) are paraffinic hydrocarbons. They are free of aromatics, have high cetane numbers and reduce emissions. HVO can be used as component or as such. HVO processes can also be modified to produce jet fuel. GHG savings by HVO use are significant compared to fossil fuels. HVO is already in commercial production. Neste Oil is producing its NExBTL diesel in two plants. Production of renewable fuels will be limited by availability of sustainable feedstock. Therefore R and D efforts are made to expand feedstock base further.

  5. Boiling curve in high quality flow boiling

    International Nuclear Information System (INIS)

    Shiralkar, B.S.; Hein, R.A.; Yadigaroglu, G.

    1980-01-01

    The post dry-out heat transfer regime of the flow boiling curve was investigated experimentally for high pressure water at high qualities. The test section was a short round tube located downstream of a hot patch created by a temperature controlled segment of tubing. Results from the experiment showed that the distance from the dryout point has a significant effect on the downstream temperatures and there was no unique boiling curve. The heat transfer coefficients measured sufficiently downstream of the dryout point could be correlated using the Heineman correlation for superheated steam, indicating that the droplet deposition effects could be neglected in this region

  6. Method for synthesis of high quality graphene

    Science.gov (United States)

    Lanzara, Alessandra [Piedmont, CA; Schmid, Andreas K [Berkeley, CA; Yu, Xiaozhu [Berkeley, CA; Hwang, Choonkyu [Albany, CA; Kohl, Annemarie [Beneditkbeuern, DE; Jozwiak, Chris M [Oakland, CA

    2012-03-27

    A method is described herein for the providing of high quality graphene layers on silicon carbide wafers in a thermal process. With two wafers facing each other in close proximity, in a first vacuum heating stage, while maintained at a vacuum of around 10.sup.-6 Torr, the wafer temperature is raised to about 1500.degree. C., whereby silicon evaporates from the wafer leaving a carbon rich surface, the evaporated silicon trapped in the gap between the wafers, such that the higher vapor pressure of silicon above each of the wafers suppresses further silicon evaporation. As the temperature of the wafers is raised to about 1530.degree. C. or more, the carbon atoms self assemble themselves into graphene.

  7. Breeding and maintaining high-quality insects

    DEFF Research Database (Denmark)

    Jensen, Kim; Kristensen, Torsten Nygård; Heckmann, Lars-Henrik

    2017-01-01

    Insects have a large potential for sustainably enhancing global food and feed production, and commercial insect production is a rising industry of high economic value. Insects suitable for production typically have fast growth, short generation time, efficient nutrient utilization, high...... reproductive potential, and thrive at high density. Insects may cost-efficiently convert agricultural and industrial food by-products into valuable protein once the technology is finetuned. However, since insect mass production is a new industry, the technology needed to efficiently farm these animals is still...... in a starting phase. Here, we discuss the challenges and precautions that need to be considered when breeding and maintaining high-quality insect populations for food and feed. This involves techniques typically used in domestic animal breeding programs including maintaining genetically healthy populations...

  8. High Quality Virtual Reality for Architectural Exhibitions

    DEFF Research Database (Denmark)

    Kreutzberg, Anette

    2016-01-01

    This paper will summarise the findings from creating and implementing a visually high quality Virtual Reality (VR) experiment as part of an international architecture exhibition. It was the aim to represent the architectural spatial qualities as well as the atmosphere created from combining natural...... and artificial lighting in a prominent not yet built project. The outcome is twofold: Findings concerning the integration of VR in an exhibition space and findings concerning the experience of the virtual space itself. In the exhibition, an important aspect was the unmanned exhibition space, requiring the VR...... experience to be self-explanatory. Observations of different visitor reactions to the unmanned VR experience compared with visitor reactions at guided tours with personal instructions are evaluated. Data on perception of realism, spatial quality and light in the VR model were collected with qualitative...

  9. High-quality cardiopulmonary resuscitation: current and future directions.

    Science.gov (United States)

    Abella, Benjamin S

    2016-06-01

    Cardiopulmonary resuscitation (CPR) represents the cornerstone of cardiac arrest resuscitation care. Prompt delivery of high-quality CPR can dramatically improve survival outcomes; however, the definitions of optimal CPR have evolved over several decades. The present review will discuss the metrics of CPR delivery, and the evidence supporting the importance of CPR quality to improve clinical outcomes. The introduction of new technologies to quantify metrics of CPR delivery has yielded important insights into CPR quality. Investigations using CPR recording devices have allowed the assessment of specific CPR performance parameters and their relative importance regarding return of spontaneous circulation and survival to hospital discharge. Additional work has suggested new opportunities to measure physiologic markers during CPR and potentially tailor CPR delivery to patient requirements. Through recent laboratory and clinical investigations, a more evidence-based definition of high-quality CPR continues to emerge. Exciting opportunities now exist to study quantitative metrics of CPR and potentially guide resuscitation care in a goal-directed fashion. Concepts of high-quality CPR have also informed new approaches to training and quality improvement efforts for cardiac arrest care.

  10. 75 FR 41693 - Export Inspection and Weighing Waiver for High Quality Specialty Grains Transported in Containers

    Science.gov (United States)

    2010-07-19

    ... Specialty Grains Transported in Containers AGENCY: Grain Inspection, Packers and Stockyards Administration... rule to potentially make permanent the current waiver for high quality grain exported in containers... exported in containers that was established by a final rule on December 13, 2005 (70 FR 73556). This...

  11. Toward High Quality Family Day Care for Infants and Toddlers. Final Report.

    Science.gov (United States)

    Rauch, Marian D.; Crowell, Doris C.

    Reported were the results of a project which established a cluster of family day care homes in Hawaii in which caregivers were selected, trained, and provided with supportive services and salaries. The primary objective of the program was to provide a replicable, high quality program for preschool children that would maximize social, emotional,…

  12. Establishing a pricing structure for software products : Case study: Viope Solutions Oy

    OpenAIRE

    Nguyen, Tram

    2013-01-01

    This thesis is a case study that explores how to establish a pricing structure for software products. The objective is to provide a guideline to establish a pricing structure for Viope Solutions Oy. A new pricing structure is crucial for the company due to recent changes in its business such as internationalisation and new product launches. The literature review introduces five attributes of a pricing structure. They are the unit definition, price determination, price segmentation, versio...

  13. Real-World Solutions for Developing High-Quality PHP Frameworks and Applications

    CERN Document Server

    Bergmann, Sebastian

    2011-01-01

    Learn to develop high-quality applications and frameworks in PHP Packed with in-depth information and step-by-step guidance, this book escorts you through the process of creating, maintaining and extending sustainable software of high quality with PHP. World-renowned PHP experts present real-world case studies for developing high-quality applications and frameworks in PHP that can easily be adapted to changing business requirements. . They offer different approaches to solving  typical development and quality assurance problems that every developer needs to know and master.Details the process

  14. Computer-aided control of high-quality cast iron

    Directory of Open Access Journals (Sweden)

    S. Pietrowski

    2008-04-01

    Full Text Available The study discusses the possibility of control of the high-quality grey cast iron and ductile iron using the author’s genuine computer programs. The programs have been developed with the help of algorithms based on statistical relationships that are said to exist between the characteristic parameters of DTA curves and properties, like Rp0,2, Rm, A5 and HB. It has been proved that the spheroidisation and inoculation treatment of cast iron changes in an important way the characteristic parameters of DTA curves, thus enabling a control of these operations as regards their correctness and effectiveness, along with the related changes in microstructure and mechanical properties of cast iron. Moreover, some examples of statistical relationships existing between the typical properties of ductile iron and its control process were given for cases of the melts consistent and inconsistent with the adopted technology.A test stand for control of the high-quality cast iron and respective melts has been schematically depicted.

  15. Establishing contact and gaining trust : an exploratory study of care avoidance

    NARCIS (Netherlands)

    Schout, Gert; de Jong, Gideon; Zeelen, Jacques

    Title. Establishing contact and gaining trust: an exploratory study of care avoidance. Aim. This paper is a report of a study conducted to explore the competencies especially deep-rooted personal qualities - of care providers who succeed in making contact and gaining trust with clients who are

  16. Feasibility study on the establishment of the IAEA international nuclear university

    International Nuclear Information System (INIS)

    Lee, E. J.; Kim, Y. T.; Nam, Y. M. and others

    2002-09-01

    The purpose of this project is to support 2002-2003 the IAEA project D.4.0.2, facilitating education, training and research in nuclear science and related fields, especially for a feasibility study on the establishment of the Agency sponsored International Nuclear University. Through this project, the abstract principle for a feasibility study on the establishment of the Agency sponsored International Nuclear university, which contains the new concepts and its objectives, principles to achieve the objectives, its curriculum outline and operation system, suggested project activities, was developed and submitted to the Agency. The Korean proposal were presented several times at the IAEA meetings and other international meetings related nuclear human resources development for understanding the necessity of a feasibility study on the establishment of the Agency sponsored international nuclear university with Member States. And the Korean proposal included such as the organization of a worldwide network using information and communication technology among Merber States' research institutes and training/education centers, curriculum outline and operation system of the INU will be produced. Also for further cooperation of the IAEA INU project implementation with the Agency, hosting IAEA INIS mirror site, establishment of the RCA region office, establishment of the INTEC at the Korean Atomic Energy Research Institute, and advanced curriculum of nuclear technology linked with NT, BT, ET, IT were made progress as a part of conceptualizing of the IAEA project

  17. Establishment of Japan Atomic Energy Agency and strategy for nuclear non-proliferation studies

    International Nuclear Information System (INIS)

    Senzaki, Masao; Kurasaki, Takaaki; Inoue, Naoko

    2005-01-01

    Japan Atomic Energy Agency (JAEA) was established on October 1, 2005, after the merger of Japan Atomic Energy Research Institute and Japan Nuclear Cycle Development Institute. JAEA is the only governmental nuclear research and development institute in Japan. It will engage in research activities ranging from basic research to practical applications in the nuclear field and will operate research laboratories, reactors, a reprocessing plant and a fuel fabrication plant. At the same time, the Nuclear Nonproliferation Science and Technology Center (NPSTC) was also established inside of JAEA to conduct the studies on the strategy for nuclear nonproliferation studies. Five roles that JAEA should play for nuclear nonproliferation were identified and four offices were established in the center to carry out those five roles effectively. To conduct the research and development for nuclear nonproliferation efficiently, the center aims to be a 'Research Hub' based on Partnership' with other organizations. (author)

  18. CHOREOGRAPHIC METHODS FOR CREATING NOVEL, HIGH QUALITY DANCE

    Directory of Open Access Journals (Sweden)

    David Kirsh

    2016-02-01

    Full Text Available We undertook a detailed ethnographic study of the dance creation process of a noted choreographer and his distinguished troupe. All choreographer dancer interactions were videoed, the choreographer and dancers were interviewed extensively each day, as well as other observations and tests performed. The choreographer used three main methods to produce high quality and novel content: showing, making-on, and tasking. We present, analyze and evaluate these methods, and show how these approaches allow the choreographer to increase the creative output of the dancers and him. His methods, although designed for dance, apply more generally to other creative endeavors, especially where brainstorming is involved, and where the creative process is distributed over many individuals. His approach is also a case study in multi-modal direction, owing to the range of mechanisms he uses to communicate and direct.

  19. Identifying suitable substrates for high-quality graphene-based heterostructures

    Science.gov (United States)

    Banszerus, L.; Janssen, H.; Otto, M.; Epping, A.; Taniguchi, T.; Watanabe, K.; Beschoten, B.; Neumaier, D.; Stampfer, C.

    2017-06-01

    We report on a scanning confocal Raman spectroscopy study investigating the strain-uniformity and the overall strain and doping of high-quality chemical vapour deposited (CVD) graphene-based heterostuctures on a large number of different substrate materials, including hexagonal boron nitride (hBN), transition metal dichalcogenides, silicon, different oxides and nitrides, as well as polymers. By applying a hBN-assisted, contamination free, dry transfer process for CVD graphene, high-quality heterostructures with low doping densities and low strain variations are assembled. The Raman spectra of these pristine heterostructures are sensitive to substrate-induced doping and strain variations and are thus used to probe the suitability of the substrate material for potential high-quality graphene devices. We find that the flatness of the substrate material is a key figure for gaining, or preserving high-quality graphene.

  20. Research and development of photovoltaic power system. Study on growth mechanism of a-Si:H and preparation of the stable, high quality films; Taiyoko hatsuden system no kenkyu kaihatsu. Amorphous silicon no seimaku kiko to kohinshitsuka

    Energy Technology Data Exchange (ETDEWEB)

    Hirose, M [Hiroshima University, Hiroshima (Japan). Faculty of Engineering

    1994-12-01

    This paper reports the result obtained during fiscal 1994 on research on a film forming mechanism for amorphous silicon for solar cells and its quality improvement. In in-situ observation on plasma CVD surface reaction by using the total reflection infrared absorbing spectroscopy, an observation on a real time basis was performed on the reaction process of an a-Si:H surface in contact with gas mixture plasma composed of SiH4 + CH4. In microscopic observation on initial processes of amorphous silicon growth, surface morphological change before and after a-Si:H deposition at 200{degree}C was observed by using an inter-atomic force microscope. The observation verified that a-Si:H has grown to an atomic layer. In research on defect density in a-Si:H fabricated under high-speed film forming conditions, analysis was made on correlation between the film forming speed at 250{degree}C and defect density in the film. Other research works include those on a high-quality a-SiGe:H film fabricated by using the nanometer film forming/hydrogen plasma annealing method, modulated doping into multi-layer films of a-Si:H/a-Ge:H, and thin film transistor using very thin multi layer films of a-Si:H/a-Ge:H. 5 refs., 12 figs.

  1. A Study of the Need to Establish a Market-oriented Culture in ...

    African Journals Online (AJOL)

    A Study of the Need to Establish a Market-oriented Culture in Educational ... critical in getting the word out to the target market, i.e. learners and parents, that the institution ... A typical marketing mix for developing an effective marketing strategy, ...

  2. A Study of the Need to Establish a Market-oriented Culture in ...

    African Journals Online (AJOL)

    A Study of the Need to Establish a Market-oriented Culture in Educational Institutions in Zimbabwe. ... The promotional culture of marketing is critical in getting the word out to the target market, i.e. ... EMAIL FULL TEXT EMAIL FULL TEXT

  3. Preliminary study on the establishment of the radionuclide declaration methods for radionuclides in LILW radioactive waste

    International Nuclear Information System (INIS)

    Hwang, K. H.; Lee, K. J.; Jung, C. W.

    2003-01-01

    The preliminary study on declaration methods has been done for each radionuclide in LILW radwaste drum in Korean NPPs. View from the preliminary establishment of radio nuclide declaration methods, The selection of assessment target nuclide through the qualitative method and preliminary criteria for routine declaration methods in each radio nuclide was derived. First of all, selection criteria and preliminary assessment method for each target radionuclide was surveyed and investigated. And, the selection criteria and selected the target radio nuclides from the basis on criteria was derived. And the preliminary suggestion about the declaration methods for each target radio nuclide was established

  4. A roadmap to high quality chemically prepared graphene

    Energy Technology Data Exchange (ETDEWEB)

    Gengler, Regis Y N; Spyrou, Konstantinos; Rudolf, Petra, E-mail: r.gengler@rug.n, E-mail: p.rudolf@rug.n [Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 4, 9747AG Groningen (Netherlands)

    2010-09-22

    Graphene was discovered half a decade ago and proved the existence of a two-dimensional system which becomes stable as a result of 3D corrugation. It appeared very quickly that this exceptional material had truly outstanding electronic, mechanical, thermal and optical properties. Consequently a broad range of applications appeared, as the graphene science speedily moved forward. Since then, a lot of effort has been devoted not only to the study of graphene but also to its fabrication. Here we review the chemical approaches to graphene production, their advantages as well as their downsides. Our aim is to draw a roadmap of today's most reliable path to high quality graphene via chemical preparation.

  5. A roadmap to high quality chemically prepared graphene

    International Nuclear Information System (INIS)

    Gengler, Regis Y N; Spyrou, Konstantinos; Rudolf, Petra

    2010-01-01

    Graphene was discovered half a decade ago and proved the existence of a two-dimensional system which becomes stable as a result of 3D corrugation. It appeared very quickly that this exceptional material had truly outstanding electronic, mechanical, thermal and optical properties. Consequently a broad range of applications appeared, as the graphene science speedily moved forward. Since then, a lot of effort has been devoted not only to the study of graphene but also to its fabrication. Here we review the chemical approaches to graphene production, their advantages as well as their downsides. Our aim is to draw a roadmap of today's most reliable path to high quality graphene via chemical preparation.

  6. Tailoring reablement: A grounded theory study of establishing reablement in a community setting in Norway.

    Science.gov (United States)

    Moe, Cathrine; Brinchmann, Berit Støre

    2018-01-01

    Reablement is an interprofessional, home-based rehabilitation service that aims to enable senior residents to cope with everyday life and to prevent functional impairments. Systematic accounts of what practitioners actually do when establishing reablement are lacking. This study aims to generate a grounded theory of practitioners' patterns of action when establishing reablement. The study is located in Norway, and grounded theory is the methodological approach. Data were collected from January 2014 to August 2016 through participant observations, focus group interviews and individual interviews. Informants are municipal healthcare employees in different organisational areas associated with the process of establishing reablement services (managers of conventional home care and representatives from the administration and service-provider offices). Altogether, 17 individuals are interviewed. The empirical data are analysed several times using open, selective and theoretical coding. The grounded theory, "tailoring reablement," includes three phases-replicating, adapting and establishing-and the strategies of collaborating, developing knowledge, habituating and filtering. The theory of tailoring reablement also includes the impact of the contextual factors. The study seeks to bridge the gap between research and practice. The theory of tailoring reablement emerges from an inductive approach and theorises participants' actions. The theory focuses on the phases from innovation to implementation. Establishing a new service model in a complex welfare setting requires a wide range of actors and agencies. Tailoring reablement also requires flexibility and professional autonomy. It is important to create terms and conditions for this within a stringent health and care service. The insights of this study have implications for practice development of reablement and can fit other public sector fields. © 2017 The Authors. Health and Social Care in the Community Published by John

  7. Establishing a Consortium for the Study of Rare Diseases: The Urea Cycle Disorders Consortium

    Science.gov (United States)

    Seminara, Jennifer; Tuchman, Mendel; Krivitzky, Lauren; Krischer, Jeffrey; Lee, Hye-Seung; LeMons, Cynthia; Baumgartner, Matthias; Cederbaum, Stephen; Diaz, George A.; Feigenbaum, Annette; Gallagher, Renata C.; Harding, Cary O.; Kerr, Douglas S.; Lanpher, Brendan; Lee, Brendan; Lichter-Konecki, Uta; McCandless, Shawn E.; Merritt, J. Lawrence; Oster-Granite, Mary Lou; Seashore, Margretta R.; Stricker, Tamar; Summar, Marshall; Waisbren, Susan; Yudkoff, Marc; Batshaw, Mark L.

    2010-01-01

    The Urea Cycle Disorders Consortium (UCDC) was created as part of a larger network established by the National Institutes of Health to study rare diseases. This paper reviews the UCDC’s accomplishments over the first six years, including how the Consortium was developed and organized, clinical research studies initiated, and the importance of creating partnerships with patient advocacy groups, philanthropic foundations and biotech and pharmaceutical companies. PMID:20188616

  8. Determinant attributes in the purchase decision: a study on street food establishments

    OpenAIRE

    Loriato, Hannah Nicchio; Pelissari, Anderson Soncini

    2017-01-01

    Abstract The importance of the attributes of a product can vary greatly according to the different consumers, thus we start from the idea that there are different degrees of importance in relation to the attributes and that this importance influences the buying decision. The purpose of this study is to identify which attributes are key in the buying decision-making process for consumers in making buying decisions in establishments that sell street food. It is a study of both qualitative and q...

  9. A study on the establishment of a nuclear regulators' association in the Northeast Asia

    International Nuclear Information System (INIS)

    Shin, Won Ky; Park, Y. S.; Lee, H. J.; Park, D. K.; Choi, K. S.; Park, C. H.; Hwang, S. C.; Do, K. S.; Choi, Y. S.

    2001-12-01

    It is desirable to make joint efforts among northeast countries in order to assure nuclear safety in northeast Asia where nuclear power development has been active. In this regard, through this study, it is developed the draft for the establishment of a regional cooperative mechanism in the field of nuclear safety regulation in this region. This will be utilized as a basic references to plan and conduct regional cooperation in the field of nuclear safety regulation in this region. Through this study, the status of multilateral cooperative mechanisms in nuclear safety field, domestic and international nuclear safety trends, and nuclear safety cooperation status in this region are investigated. Based on this investigation, the draft for the establishment of the Nuclear Regulators Meeting in the Northeast Asia (NUREMA) and its implementation plan are developed. If the NUREMA is successfully established and operated, it will serve as a central basis for exchanging regulatory related information, experience, and techniques, etc., which will strengthen domestic and regional nuclear safety. It is desirable to strengthen the MOST∼NNSA∼METI Tripartite Meeting on a step by step basis for the next few years (4 - 5 years) and finally establish a multilateral cooperative mechanism like NUREMA

  10. Publishing high-quality climate data on the semantic web

    Science.gov (United States)

    Woolf, Andrew; Haller, Armin; Lefort, Laurent; Taylor, Kerry

    2013-04-01

    The effort over more than a decade to establish the semantic web [Berners-Lee et. al., 2001] has received a major boost in recent years through the Open Government movement. Governments around the world are seeking technical solutions to enable more open and transparent access to Public Sector Information (PSI) they hold. Existing technical protocols and data standards tend to be domain specific, and so limit the ability to publish and integrate data across domains (health, environment, statistics, education, etc.). The web provides a domain-neutral platform for information publishing, and has proven itself beyond expectations for publishing and linking human-readable electronic documents. Extending the web pattern to data (often called Web 3.0) offers enormous potential. The semantic web applies the basic web principles to data [Berners-Lee, 2006]: using URIs as identifiers (for data objects and real-world 'things', instead of documents) making the URIs actionable by providing useful information via HTTP using a common exchange standard (serialised RDF for data instead of HTML for documents) establishing typed links between information objects to enable linking and integration Leading examples of 'linked data' for publishing PSI may be found in both the UK (http://data.gov.uk/linked-data) and US (http://www.data.gov/page/semantic-web). The Bureau of Meteorology (BoM) is Australia's national meteorological agency, and has a new mandate to establish a national environmental information infrastructure (under the National Plan for Environmental Information, NPEI [BoM, 2012a]). While the initial approach is based on the existing best practice Spatial Data Infrastructure (SDI) architecture, linked-data is being explored as a technological alternative that shows great promise for the future. We report here the first trial of government linked-data in Australia under data.gov.au. In this initial pilot study, we have taken BoM's new high-quality reference surface

  11. A study on the establishment of nuclear cooperative relations and future direction between Korea and Vietnam

    Energy Technology Data Exchange (ETDEWEB)

    Yang, M H; Kim, H S; Chung, W S; Yun, S W; Ko, H S; Lee, J K

    2000-10-01

    This study was carried out in order to review the cooperation with vietnam and establish and activate the cooperative relations with Vietnam. During the study, current status of use and development of nuclear energy in vietnam, were investigated including nuclear power plant and cooperative relations between two nations were also established. It was agreed through exchanges of visits of cooperation delegation; 1) exchange of visits of cooperation delegation, 2) holding of policy seminar for high level decision makers of Vietnam 3) cooperaton between KAERI/VAEC, 4) joint feasibility study for the construction of KSNP into Vietnam and technical presentation of KSNP. It is recommended that cooperaion with vietnam be implemented systematically through the long term based basic directions and integrated national strategies.

  12. A study on the establishment of nuclear cooperative relations and future direction between Korea and Vietnam

    International Nuclear Information System (INIS)

    Yang, M. H.; Kim, H. S.; Chung, W. S.; Yun, S. W.; Ko, H. S.; Lee, J. K.

    2000-10-01

    This study was carried out in order to review the cooperation with vietnam and establish and activate the cooperative relations with Vietnam. During the study, current status of use and development of nuclear energy in vietnam, were investigated including nuclear power plant and cooperative relations between two nations were also established. It was agreed through exchanges of visits of cooperation delegation; 1) exchange of visits of cooperation delegation, 2) holding of policy seminar for high level decision makers of Vietnam 3) cooperaton between KAERI/VAEC, 4) joint feasibility study for the construction of KSNP into Vietnam and technical presentation of KSNP. It is recommended that cooperaion with vietnam be implemented systematically through the long term based basic directions and integrated national strategies

  13. Can establishment success be determined through demographic parameters? A case study on five introduced bird species.

    Directory of Open Access Journals (Sweden)

    Ana Sanz-Aguilar

    Full Text Available The dominant criterion to determine when an introduced species is established relies on the maintenance of a self-sustaining population in the area of introduction, i.e. on the viability of the population from a demographic perspective. There is however a paucity of demographic studies on introduced species, and establishment success is thus generally determined by expert opinion without undertaking population viability analyses (PVAs. By means of an intensive five year capture-recapture monitoring program (involving >12,000 marked individuals we studied the demography of five introduced passerine bird species in southern Spain which are established and have undergone a fast expansion over the last decades. We obtained useful estimates of demographic parameters (survival and reproduction for one colonial species (Ploceus melanocephalus, confirming the long-term viability of its local population through PVAs. However, extremely low recapture rates prevented the estimation of survival parameters and population growth rates for widely distributed species with low local densities (Estrilda troglodytes and Amandava amandava but also for highly abundant yet non-colonial species (Estrilda astrild and Euplectes afer. Therefore, determining the establishment success of introduced passerine species by demographic criteria alone may often be troublesome even when devoting much effort to field-work. Alternative quantitative methodologies such as the analysis of spatio-temporal species distributions complemented with expert opinion deserve thus their role in the assessment of establishment success of introduced species when estimates of demographic parameters are difficult to obtain, as is generally the case for non-colonial, highly mobile passerines.

  14. Simulation of High Quality Ultrasound Imaging

    DEFF Research Database (Denmark)

    Hemmsen, Martin Christian; Kortbek, Jacob; Nikolov, Svetoslav Ivanov

    2010-01-01

    ), and at Full Width at One-Hundredth Maximum (FWOHM) of 9 points spread functions resulting from evenly distributed point targets at depths ranging from 10 mm to 90 mm. The results are documented for a 64 channel system, using a 192 element linear array transducer model. A physical BK Medical 8804 transducer...... amplitude and phase compensation, the LR at FWOHM improves from 6.3 mm to 4.7 mm and is a factor of 2.2 better than DRF. This study has shown that individual element impulse response, phase, and amplitude deviations are important to include in simulated system performance evaluations. Furthermore...

  15. Establishing supervisor-students’ relationships through mutual expectation: A study from supervisors’ point of view

    Science.gov (United States)

    Masek, Alias

    2017-08-01

    The literature suggests that failure to establish a good relationship in communicating expectations of research supervision is one of the factors contributing to the slow pace of research progress. Moreover, it is not fully understood how students and a supervisor ‘pre-define’ their styles and communicate their expectations through a successful relationship. As a result, the students might lose motivation to do their research during the study period and are not able to complete their research on time. This will subsequently entail an extension of the study period. Without a good relationship between students and the supervisor, miscommunication occurs, leading to mismatched expectations from both parties. This research attempts to explore the establishment of a good supervisor-students’ relationship from supervisor point of views, so that supervision expectations can be clearly delivered and effectively communicated; guidelines will be drawn up for forging the supervisor-students’ relationship basing on mutual expectations of both parties.

  16. Economic study for the establishment of A food irradiation facility at port said harbour

    International Nuclear Information System (INIS)

    EL-Gameel, E.A.

    2004-01-01

    The present study discusses the economic aspects of establishing food irradiation facility at Port Said harbour and the effect of various parameters on the unit processing costs. The study is concerned with carrying out an economic evaluation for the application of food exports from Port Said harbour and the marketing and technical aspects where the suitable commodity mix has been determined for the agricultural crops which were proposed for irradiation. The investment criteria utilized for commercial evaluation were internal rate of return (IRR) and pay back period (PEP). The irradiation cost and the additional income are also discussed. The results of this analysis showed that the establishment of food irradiation unit in Port Said harbour in Egypt would be economically feasible

  17. Using a site-specific technical error to establish training responsiveness: a preliminary explorative study.

    Science.gov (United States)

    Weatherwax, Ryan M; Harris, Nigel K; Kilding, Andrew E; Dalleck, Lance C

    2018-01-01

    Even though cardiorespiratory fitness (CRF) training elicits numerous health benefits, not all individuals have positive training responses following a structured CRF intervention. It has been suggested that the technical error (TE), a combination of biological variability and measurement error, should be used to establish specific training responsiveness criteria to gain further insight on the effectiveness of the training program. To date, most training interventions use an absolute change or a TE from previous findings, which do not take into consideration the training site and equipment used to establish training outcomes or the specific cohort being evaluated. The purpose of this investigation was to retrospectively analyze training responsiveness of two CRF training interventions using two common criteria and a site-specific TE. Sixteen men and women completed two maximal graded exercise tests and verification bouts to identify maximal oxygen consumption (VO 2 max) and establish a site-specific TE. The TE was then used to retrospectively analyze training responsiveness in comparison to commonly used criteria: percent change of >0% and >+5.6% in VO 2 max. The TE was found to be 7.7% for relative VO 2 max. χ 2 testing showed significant differences in all training criteria for each intervention and pooled data from both interventions, except between %Δ >0 and %Δ >+7.7% in one of the investigations. Training nonresponsiveness ranged from 11.5% to 34.6%. Findings from the present study support the utility of site-specific TE criterion to quantify training responsiveness. A similar methodology of establishing a site-specific and even cohort specific TE should be considered to establish when true cardiorespiratory training adaptations occur.

  18. Innovative and high quality education through Open Education and OER

    OpenAIRE

    Stracke, Christian M.

    2017-01-01

    Online presentation and webinar by Stracke, C. M. (2017, 18 December) on "Innovative and high quality education through Open Education and OER" for the Belt and Road Open Education Learning Week by the Beijing Normal University, China.

  19. Improving high quality, equitable maternal health services in Malawi ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Improving high quality, equitable maternal health services in Malawi (IMCHA) ... In response, the Ministry of Health implemented a Standards-Based Management and Recognition for Reproductive Health initiative to improve ... Total funding.

  20. High Quality Education and Learning for All through Open Education

    NARCIS (Netherlands)

    Stracke, Christian M.

    2016-01-01

    Keynote at the International Lensky Education Forum 2016, Yakutsk, Republic of Sakha, Russian Federation, by Stracke, C. M. (2016, 16 August): "High Quality Education and Learning for All through Open Education"

  1. A study on the establishment of nuclear cooperative relations and future direction between Korea and Egypt

    Energy Technology Data Exchange (ETDEWEB)

    Yang, M. H.; Kim, H. S.; Kim, H. J.; Yun, S. W.; Ko, H. S

    2000-10-01

    This study was carried out in order to review the cooperation with Egypt and establish and activate the cooperative relations with Egypt. Recent policy trends in the use and development of nuclear energy in Egypt, were investigated including introduction of nuclear power plant, and cooperative relations between two nations were also established under the implementation of the project. It was agreed through exchanges of visits of nuclear cooperation delegation; 1) exchange of visits of cooperation delegation, 2) invitation of egypt experts to policy seminar 3) cooperation between relevant nuclear related organizations of two countries, 4) future cooperation fields and directions between two countries. It is recommended that cooperation with Egypt be implemented systematically through the long term based on national basic cooperation directions and integrated strategies.

  2. A study on the establishment of nuclear cooperative relations and future direction between Korea and Egypt

    International Nuclear Information System (INIS)

    Yang, M. H.; Kim, H. S.; Kim, H. J.; Yun, S. W.; Ko, H. S.

    2000-10-01

    This study was carried out in order to review the cooperation with Egypt and establish and activate the cooperative relations with Egypt. Recent policy trends in the use and development of nuclear energy in Egypt, were investigated including introduction of nuclear power plant, and cooperative relations between two nations were also established under the implementation of the project. It was agreed through exchanges of visits of nuclear cooperation delegation; 1) exchange of visits of cooperation delegation, 2) invitation of egypt experts to policy seminar 3) cooperation between relevant nuclear related organizations of two countries, 4) future cooperation fields and directions between two countries. It is recommended that cooperation with Egypt be implemented systematically through the long term based on national basic cooperation directions and integrated strategies

  3. A Study on the Development of Building Energy Analysis Program and the Establishment of BEPS

    Energy Technology Data Exchange (ETDEWEB)

    Kong, S.R.; Kwon, K.J.; Yoo, Y.H.; Cho, Y.K.; Kijm, Y.D.; Han, S.W. [Korea Electric Power Corp. (KEPCO), Taejon (Korea, Republic of). Research Center; Kim, M.H.; Kim, K.W.; Cho, K.H.; Lee, H.W.; Lee, Y.H.; Kim, S.J.; Song, K.S.; Heon, C.T.; Choi, J.M.; Kim, Y.I.; Suk, H.T.; Kang, J.S.; Kim, Y.D.; Kang, K.T.; Lee, J.E.; Kwark, H.S. [Seoul National Univ. (Korea, Republic of)

    1994-12-31

    The amount of energy consumption in building covers the 30% of the total energy consumption and that of electricity is much the same. Because of the improvement of the living quality, energy consumption in building part is increasing and the rate is much higher than that of other parts. So, KEPCO, one of the major domestic energy suppliers and consumers, needs to develop reliable computerized building energy analysis program and to establish building energy performance standards for the reasonable energy management and the efficient execution of energy budget and the improvement of working condition of the corp`s buildings. So the study aims to the development of computerized building energy analysis program, and the establishment energy budget level and building energy performance standards for the corp`s buildings.

  4. A study on establishing export system of nuclear related equipments to the IAEA

    Energy Technology Data Exchange (ETDEWEB)

    Song, Ki Dong; Lee, Man Ki; Moon, Ki Hwan; Kim, Seung Soo; Lim, Chae Young; Kim, Hwa Sup; Min, Tae Sik [Korea Atomic Energy Research Institute, Taejeon (Korea)

    2002-04-01

    In spite of the advanced status in the international nuclear society, exports of domestic nuclear industries to procurement market of the international organizations has been negligible. This study briefly explained the role and the structure of the IAEA. Then, this study surveyed the size of procurement market, major procurement items, and procurement process. This study also gave an export example to the IAEA from Korea Atomic Energy Research Institute for the ease of understanding the procurement process. Based on these surveys and analysis, this study established the goal and strategy for exports of nuclear equipments to the IAEA. Besides, this study surveyed domestic nuclear industries that have potential to export their products to the IAEA. Then, Korea Atomic Energy Research Institute, by a cooperation with Korea Atomic Industrial Forum Inc., held workshop on 'export of nuclear equipments to IAEA' in May 2001 for them. 4 refs., 1 fig., 10 tabs. (Author)

  5. A study on establishing export system of nuclear related equipments to the IAEA

    Energy Technology Data Exchange (ETDEWEB)

    Song, Ki Dong; Lee, Man Ki; Moon, Ki Hwan; Kim, Seung Soo; Lim, Chae Young; Kim, Hwa Sup; Min, Tae Sik [Korea Atomic Energy Research Institute, Taejeon (Korea)

    2002-04-01

    In spite of the advanced status in the international nuclear society, exports of domestic nuclear industries to procurement market of the international organizations has been negligible. This study briefly explained the role and the structure of the IAEA. Then, this study surveyed the size of procurement market, major procurement items, and procurement process. This study also gave an export example to the IAEA from Korea Atomic Energy Research Institute for the ease of understanding the procurement process. Based on these surveys and analysis, this study established the goal and strategy for exports of nuclear equipments to the IAEA. Besides, this study surveyed domestic nuclear industries that have potential to export their products to the IAEA. Then, Korea Atomic Energy Research Institute, by a cooperation with Korea Atomic Industrial Forum Inc., held workshop on 'export of nuclear equipments to IAEA' in May 2001 for them. 4 refs., 1 fig., 10 tabs. (Author)

  6. Integrated Pathology Informatics Enables High-Quality Personalized and Precision Medicine: Digital Pathology and Beyond.

    Science.gov (United States)

    Volynskaya, Zoya; Chow, Hung; Evans, Andrew; Wolff, Alan; Lagmay-Traya, Cecilia; Asa, Sylvia L

    2018-03-01

    - The critical role of pathology in diagnosis, prognosis, and prediction demands high-quality subspecialty diagnostics that integrates information from multiple laboratories. - To identify key requirements and to establish a systematic approach to providing high-quality pathology in a health care system that is responsible for services across a large geographic area. - This report focuses on the development of a multisite pathology informatics platform to support high-quality surgical pathology and hematopathology using a sophisticated laboratory information system and whole slide imaging for histology and immunohistochemistry, integrated with ancillary tools, including electron microscopy, flow cytometry, cytogenetics, and molecular diagnostics. - These tools enable patients in numerous geographic locations access to a model of subspecialty pathology that allows reporting of every specimen by the right pathologist at the right time. The use of whole slide imaging for multidisciplinary case conferences enables better communication among members of patient care teams. The system encourages data collection using a discrete data synoptic reporting module, has implemented documentation of quality assurance activities, and allows workload measurement, providing examples of additional benefits that can be gained by this electronic approach to pathology. - This approach builds the foundation for accurate big data collection and high-quality personalized and precision medicine.

  7. Establishing Normative Values for the Barnett Balance Assessment Tool: A Preliminary Study

    Directory of Open Access Journals (Sweden)

    Monica L. Cercone MSOTS

    2014-04-01

    Full Text Available The purpose of this study was to establish normative data for the Barnett Balance Assessment (BBA for individuals ages 18-70+ years. The BBA is a newly developed assessment tool that may address limitations present in other assessments currently used to detect balance deficits. The BBA was administered to 141 participants who had no history of medical issues that could impact balance. A review of the normative data collected indicated little variation in total assessment scores in the age categories of 18-29, 30-39, and 40-49, due to the presence of a ceiling effect. Variations existed in scores among participants in the remaining age categories (50-59, 60-69, and 70+. These findings may imply that the BBA has its greatest discriminative power in assessing individuals with impaired balance, and/or that the BBA is not sensitive enough to detect differences in individuals with mild balance impairments. The researchers suggest future studies be conducted with the BBA to establish norms with populations with known orthopedic or neurological conditions that may impair balance. Results of these studies could then be compared with the baseline data gathered in this study to determine the BBA’s usefulness in detecting balance impairments with clinical populations.

  8. FEASIBILITY STUDY OF ESTABLISHING AN ARTIFICIAL INSEMINATION (AI CENTER FOR CARABAOS IN SAN ILDEFONSO, BULACAN, PHILIPPINES

    Directory of Open Access Journals (Sweden)

    F.Q. Arrienda II

    2014-10-01

    Full Text Available The productivity of the carabao subsector is influenced by several constraints such as social,technical, economic and policy factors. The need to enhance the local production of carabaos will helplocal farmers to increase their income. Thus, producing thorough breeds of carabaos and improving itgenetically is the best response to these constraints. This study was conducted to present the feasibilitystudy of establishing an Artificial Insemination (AI Center and its planned area of operation in Brgy.San Juan, Ildefonso, Bulacan. The market, production, organizational and financial viability of operatingthe business would also be evaluated. This particular study will provide insights in establishing an AICenter. Included in this study is the identification of anticipated problems that could affect the businessand recommendation of specific courses of action to counteract these possible problems. Primary datawere obtained through interviews with key informants from the Philippine. Carabao Center (PCC. Togain insights about the present status of an AI Center, interviews with the technicians of PCC and privatefarm were done to get additional information. Secondary data were acquired from various literatures andfrom San Ildefonso Municipal Office. The proposed area would be 1,500 square meters that would beallotted for the laboratory and bullpen. The AI Center will operate six days a week and will be openedfrom 8 AM until 5 PM. However, customers or farmers can call the technicians beyond the office hoursin case of emergency. The total initial investment of Php 3,825,417.39 is needed in establishing the AICenter. The whole amount will be sourced from the owner’s equity. Financial projection showed an IRRof 30% with a computed NPV of Php 2,415,597.00 and a payback period of 3.97 years. Based on all themarket, technical, organizational, financial factors, projections and data analysis, it is said that thisbusiness endeavor is viable and feasible.

  9. A Delphi study to establish national cost-effectiveness research priorities for positron emission tomography

    International Nuclear Information System (INIS)

    Robert, Glenn; Milne, Ruairidh

    1999-01-01

    Objective: This study aimed to determine the key cost-effectiveness research questions relating to positron emission tomography (PET) in the UK. Methods: A systematic literature review was conducted to establish the existing knowledge base relating to the cost-effectiveness of PET in the various conditions for which it has been proposed. A three-round postal Delphi study of relevant individuals was used to determine the key cost-effectiveness research questions relating to PET in the UK. The content and structure of the Delphi study was informed by the results of the literature review. Results: The most important cost-effectiveness research priorities for the National Health Service (NHS) relating to PET were in the clinical areas of lung cancer, breast cancer and the assessment of myocardial viability. Gamma camera PET using coincidence imaging was highlighted as a modality whose clinical role needed to be determined urgently. Conclusion: Underlying the cost-effectiveness research priorities which were established is the need for evidence that the use of the various PET modalities as a diagnostic technique will alter patient management as compared to existing diagnostic strategies. The findings of the project provide a contemporary overview of the potential role for PET in the NHS and will be relevant to other countries

  10. Study on the Standard Establishment for the Integrity Assessment of Nuclear Fuel Cladding Materials

    Energy Technology Data Exchange (ETDEWEB)

    Kang, S-S; Kim, S-H; Jung, Y-K; Yang, C-Y; Kim, I-G; Choi, Y-H; Kim, H-J; Kim, M-W; Rho, B-H [KINS, Daejeon (Korea, Republic of)

    2008-02-15

    Fuel cladding material plays important role as a primary structure under the high temperature, high pressure and neutron environment of nuclear power plant. According to this environment, cladding material can be experienced several type aging phenomena including the neutron irradiation embrittlement. On the other hand, although the early nuclear power plant was designed to fitting into the 40MWd/KgU burn-up, the currently power plant intends to go to the high burn-up range. In this case, the safety criteria which was established at low burn-up needs to conform the applicability at the high burn-up. In this study, the safety criteria of fuel cladding material was reviewed to assess the cladding material integrity, and the material characteristics of cladding were reviewed. The current LOCA criterial was also reviewed, and the basic study for re-establishment of LOCA criteria was performed. The time concept safety criteria was also discussed to prevent the breakaway oxidation. Through the this study, safety issues will be produced and be helpful for integrity insurance of nuclear fuel cladding material. This report is the final report.

  11. Study on the standard establishment for the integrity assessment of nuclear fuel cladding Materials

    Energy Technology Data Exchange (ETDEWEB)

    Kang, S. S.; Kim, S. H.; Jung, Y. K.; Yang, C. Y.; Kim, I. G.; Choi, Y. H.; Kim, H. J.; Kim, M. W.; Rho, B. H. [Korea Institute of Nuclear Safety, Daejeon (Korea, Republic of)

    2007-02-15

    Fuel cladding material plays important role as a primary structure under the high temperature, high pressure and neutron environment of nuclear power plant. According to this environment, cladding material can be experienced several type aging phenomena including the neutron irradiation embrittlement. On the other hand, although the early nuclear power plant was designed to fitting into the 40MWd/KgU burn-up, the currently power plant intends to go to the high burn-up range. In this case, the safety criteria which was established at low burn-up needs to conform the applicability at the high burn-up. In this study, the safety criteria of fuel cladding material was reviewed to assess the cladding material integrity, and the material characteristics of cladding were reviewed. The current LOCA criterial was also reviewed, and the basic study for re-establishment of LOCA criteria was performed. The time concept safety criteria was also discussed to prevent the breakaway oxidation. Through the this study, safety issues will be produced and be helpful for integrity insurance of nuclear fuel cladding material. This report is 2nd term report.

  12. Development of a high-quality cut-off wall using electrophoresis

    International Nuclear Information System (INIS)

    Kawachi, T.; Murahashi, H.

    1991-01-01

    Techniques to build a high-quality cut-off wall have been developed for storage facilities of low-level radioactive waste (LLW) as an emergency measures to prevent leakages. The cut-off wall is highly impermeable, nucleid-adsorptive and have long-term durability. Electrophoresis is used to form impermeable membrane of bentonite as main features of the cut-off wall. First of all, laboratory tests have been conducted to study ways of building barriers on site and to collect data on the barriers properties. Afterwards, on-site construction tests of a high-quality cut-off wall have been carried out. In this paper, we describe the process and results on the studies of the high-quality cut-off wall using electrophoresis

  13. A study to establish international diagnostic reference levels for paediatric computed tomography

    International Nuclear Information System (INIS)

    Vassileva, J.; Rehani, M.; Kostova-Lefterova, D.; Al-Naemi, H.M.; Al Suwaidi, J.S.; Arandjic, D.; Bashier, E.H.O.; Kodlulovich Renha, S.; El-Nachef, L.; Aguilar, J.G.; Gershan, V.; Gershkevitsh, E.; Gruppetta, E.; Hustuc, A.; Jauhari, A.; Hassan Kharita, Mohammad; Khelassi-Toutaoui, N.; Khosravi, H.R.; Khoury, H.; Kralik, I.; Mahere, S.; Mazuoliene, J.; Mora, P.; Muhogora, W.; Muthuvelu, P.; Nikodemova, D.; Novak, L.; Pallewatte, A.; Pekarovic, D.; Shaaban, M.; Shelly, E.; Stepanyan, K.; Thelsy, N.; Visrutaratna, P.; Zaman, A.

    2015-01-01

    The article reports results from the largest international dose survey in paediatric computed tomography (CT) in 32 countries and proposes international diagnostic reference levels (DRLs) in terms of computed tomography dose index (CTDI vol ) and dose length product (DLP). It also assesses whether mean or median values of individual facilities should be used. A total of 6115 individual patient data were recorded among four age groups: <1 y, >1-5 y, >5-10 y and >10-15 y. CTDI w , CTDI vol and DLP from the CT console were recorded in dedicated forms together with patient data and technical parameters. Statistical analysis was performed, and international DRLs were established at rounded 75. percentile values of distribution of median values from all CT facilities. The study presents evidence in favour of using median rather than mean of patient dose indices as the representative of typical local dose in a facility, and for establishing DRLs as third quartile of median values. International DRLs were established for paediatric CT examinations for routine head, chest and abdomen in the four age groups. DRLs for CTDI vol are similar to the reference values from other published reports, with some differences for chest and abdomen CT. Higher variations were observed between DLP values, based on a survey of whole multi-phase exams. It may be noted that other studies in literature were based on single phase only. DRLs reported in this article can be used in countries without sufficient medical physics support to identify non-optimised practice. Recommendations to improve the accuracy and importance of future surveys are provided. (authors)

  14. [Experimental study on establishment of a simple model of rats crush injury-crush syndrome].

    Science.gov (United States)

    Chen, Xi; Liu, Yuehong; Xu, Wei; Qin, Tingwu; Zhao, Luping; Liu, Shuping; Zhang, Yi; Tan, Hong; Zhou, Yu

    2013-01-01

    To establish a repeatable, simple, and effective model of rat crush injury and crush syndrome. A total of 42 female Sprague Dawley rats (2-month-old, (CS) so as to lay a foundation for further study on CS. weighing 160-180 g) were divided randomly into the control group (n=6) and experimental group (n=36). The rats of the experimental group were used to establish the crush injury and CS model in both lower limbs by self-made crush injury mould. The survival rate and hematuria rate were observed after decompression. The biochemical indexes of blood were measured at 2, 4, 8, 12, 24, and 48 hours after decompression. The samples of muscle, kidney, and heart were harvested for morphological observation. There was no treatment in the control group, and the same tests were performed. Seven rats died and 15 rats had hematuria during compression in the experimental group. Swelling of the lower limb and muscle tissue was observed in the survival rats after reperfusion. The liver function test results showed that the levels of alanine transaminase and aspartate aminotransferase in the experimental group were significantly higher than those in the control group (P congestion and swelling, renal tubular epithelial cell degeneration, edema, necrosis, and myoglobin tube type were found in the kidneys; and myocardial structure had no obvious changes. The method of the crush injury and CS model by self-made crush injury mould is a simple and effective procedure and the experimental result is stable. It is a simple method to establish an effective model of rats crush injury and CS.

  15. High Quality RNA Isolation from Leaf, Shell, Root Tissues and Callus of Hazelnut (Corylus avellana L.

    Directory of Open Access Journals (Sweden)

    Hossein Khosravi

    2017-12-01

    Full Text Available Extraction of high quality RNA is a critical step in molecular genetics studies. Hazelnut is one of the most important nuts plants in the world. The presence of the taxol and other taxanes in hazelnut plant necessitates explaining their biosynthesis pathway and identifying the candidate genes. Therefore, an easy and practical method is necessary for RNA extraction from hazelnuts. Hazelnut has high levels of phenolic compounds. High amounts of polyphenolic and polysaccharide compounds in plants could be causing problems in RNA extraction procedures.  To avoid these problems, a simple and efficient method can be used based on cetyltrimethylammonium bromide (CTAB extraction buffer and lithium chloride for extraction of high quality RNA from different parts of hazelnut plant. Using this method, a high-quality RNA sample (light absorbed in the A260/A280 was 2.04

  16. A methodology to establish a database to study gene environment interactions for childhood asthma

    Directory of Open Access Journals (Sweden)

    McCormick Jonathan

    2010-12-01

    Full Text Available Abstract Background Gene-environment interactions are likely to explain some of the heterogeneity in childhood asthma. Here, we describe the methodology and experiences in establishing a database for childhood asthma designed to study gene-environment interactions (PAGES - Paediatric Asthma Gene Environment Study. Methods Children with asthma and under the care of a respiratory paediatrician are being recruited from 15 hospitals between 2008 and 2011. An asthma questionnaire is completed and returned by post. At a routine clinic visit saliva is collected for DNA extraction. Detailed phenotyping in a proportion of children includes spirometry, bronchodilator response (BDR, skin prick reactivity, exhaled nitric oxide and salivary cotinine. Dietary and quality of life questionnaires are completed. Data are entered onto a purpose-built database. Results To date 1045 children have been invited to participate and data collected in 501 (48%. The mean age (SD of participants is 8.6 (3.9 years, 57% male. DNA has been collected in 436 children. Spirometry has been obtained in 172 children, mean % predicted (SD FEV1 97% (15 and median (IQR BDR is 5% (2, 9. There were differences in age, socioeconomic status, severity and %FEV1 between the different centres (p≤0.024. Reasons for non-participation included parents not having time to take part, children not attending clinics and, in a small proportion, refusal to take part. Conclusions It is feasible to establish a national database to study gene-environment interactions within an asthmatic paediatric population; there are barriers to participation and some different characteristics in individuals recruited from different centres. Recruitment to our study continues and is anticipated to extend current understanding of asthma heterogeneity.

  17. Study on the establishment of retrospective dosimetry system for nuclear radiation accident(II)

    Energy Technology Data Exchange (ETDEWEB)

    Jun, Jae Shik; Chai, Ha Seok; Lee, Jong Ok [Chungnam National Univ., Taejon (Korea, Republic of)

    1999-03-15

    This study was driven forward centering around physical techniques in retrospective dosimetry system for encountering nuclear radiation accident. The results obtained through this study are summarized as follow : the minimal facilities based on physical techniques should be assured at KINS for appropriate operation and establishment of retrospective accident dosimetry system, the necessary apparatus and man power for retrospective dose assessment by physical techniques might be operated flexibly, however, CL and TL/OSL readers should be equipped with the highest priority, a series of comparative examination of several physical techniques for retrospective dose assessment revealed that most of the irradiated materials around accident sites are usable for the dose assessment, if a priori study on the dosimetrical characteristics of those materials is preceded in accordance with the species of the collectable samples, the results of the study on the CL-dose response and radiation energy dependence of sugar and sorbitol, showed the nonlinearity in CL-dose relationship at the range of low dose(less than 5 Gy), and it led us to perform a study on the correction of the nonlinearity, and in the later study, CL output showed heavy dependence on radiation energy in the energy below around 100 keV and accordingly, a study on the correction for the energy dependence was also carried out, ve were able to obtain good results as a first attempt to carry out such corrections.

  18. Establishment and Development of the Nuclear Knowledge Management Program in FANR: Case Study

    International Nuclear Information System (INIS)

    Al Mansoori, S.; Al Khadouri, A.

    2016-01-01

    Full text: In 2011, FANR officially started the establishment and development of a nuclear knowledge management (NKM) program. During the past period, the program went through different challenges, obstacles and successes. Some of current FANR NKM initiatives and practices considered as new solutions in the field of KM practices. For example, using knowledge resource matrix, KM process integration and others. However, applying new practices and tools does not mean that FANR NKM found solutions for all the challenges that can be faced by similar KM programs, challenges like preparing for identifying critical knowledge required in the operation phase period, or identifying and capturing the establishment phase and construction knowledge. FANR management are aware of those challenges and are working as one team with internal and external stakeholders to solve them on a priority basis through open discussions, direct directives, collaboration and benchmarking, as well as strategic planning and supporting innovative solutions. The methodologies and practices that it will share in the conference might change some NKM programs’ implementation approaches, however, it is certain that something new related to NKM implementation philosophy will be picked up from this case study. (author

  19. Food poisoning outbreak in a training establishment: A retrospective cohort study

    Directory of Open Access Journals (Sweden)

    Maramraj Kiran Kumar

    2017-01-01

    Full Text Available Background: An outbreak of food poisoning occurred among recruits in a training establishment. Investigation of outbreak was undertaken with active preventive interventions concurrently to arrest the current outbreak as well as to avoid such incidents in future. Materials and Methods: A retrospective cohort study was undertaken among all recruits, regardless of presence or absence of symptoms. The risk ratios (relative risks and attributable risks were calculated for each food item of the suspected meal to assess the association between consumption of individual food items and subsequent illness. An environmental survey was undertaken to investigate into the course of food processing and storage facilities at trainees' galley (cookhouse and other relevant eating establishments. Results: A total of 494 recruits reported with symptoms of gastroenteritis in a span of 3 days. Of those affected, only 9 were admitted and rest recovered with treatment on OPD basis. The overall attack rate was 22.9%. No deaths were reported. It was a classical point source, single exposure gastroenteritis outbreak. When food histories and sickness histories were analyzed, the attributable risk (24.17 and relative risk (5.11 were highest for the “Flavoured milk,” which was an outsourced item. The statistical findings were substantiated with environmental and epidemiological evidence. Conclusion: Epidemiological investigation incriminated dinner of the previous day as the meal responsible for the outbreak with flavored milk as the most attributable food item.

  20. A study of the emotions established during the social interactions inside a classroom

    Directory of Open Access Journals (Sweden)

    Isabel Cristina de Castro Monteiro

    2007-03-01

    Full Text Available The searching for a better understanding of the interactive process that is taken place inside a classroom has motivated the development of some researches, willing to visualize its main complex and multiple variables that are established among its members. It is important to mention that such variables should be concerned not only with their cognitive aspect, but the subjective and emotional aspects, as well, since they could represent an obstacle or a tool when dealing with the whole learning process.And based on such concept and the Vigotski´s theory, we have decided to study the main social interactions and the emotions that were released between a Physics Teacher and her students, when teaching the theory of a body in a state of static equilibrium. The outcomes have shown that the teacher should be aware of the emotional aspects regarding the social interaction that are established with and among the students, optimizing in that way the educational resources applied inside the classroom.

  1. Study on international publicity and export strategy establishment of nuclear technology

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Ji Bok; Choi, C.O.; Park, K. B.; Chang, M. H.; Kim, K. K.; Yang, M. S.; Jung, I. H.; Kim, K. P.; Wu, J. S.; Jang, C. I.; Han, B. O.; Sim, J. H.; Chung, M.; Chung, J.K

    1999-05-01

    The objective of this study is to devise a proper measure for international publicity and technology export strategy. Analysed and summaries in detail are other countries nuclear policy trend and the current technology development status of Korea Standard Nuclear Plant that we developed on our own technology, design and construction technology for research reactor, System-integrated Modular Advanced Reactor of which design is in progress, Direct use of Spent PWR Fuel in CANDU Reactors, and Radioisotopes. Based on that, the measures are proposed for the export industrialization of nuclear technology and establishment of the export basis. Also the international nuclear cooperation and publicity strategy are suggested to support the technology export basis. By surveying the world nuclear status, the direction for the international cooperation and publicity is settled and the specific publicity strategy is proposed for the cooperation with IAEA and multi-countries and the establishment of the nuclear technology export basis. As part of this project, the panel on major technologies such as Korea Standard Nuclear Plant, HANARO, and System-integrated Modular Advanced Reactor was displayed successfully at the IAEA meeting, which contribute much to the publicity of our nuclear technology to the international nuclear society. (author)

  2. Concrete Waste Recycling Process for High Quality Aggregate

    International Nuclear Information System (INIS)

    Ishikura, Takeshi; Fujii, Shin-ichi

    2008-01-01

    Large amount of concrete waste generates during nuclear power plant (NPP) dismantling. Non-contaminated concrete waste is assumed to be disposed in a landfill site, but that will not be the solution especially in the future, because of decreasing tendency of the site availability and natural resources. Concerning concrete recycling, demand for roadbeds and backfill tends to be less than the amount of dismantled concrete generated in a single rural site, and conventional recycled aggregate is limited of its use to non-structural concrete, because of its inferior quality to ordinary natural aggregate. Therefore, it is vital to develop high quality recycled aggregate for general uses of dismantled concrete. If recycled aggregate is available for high structural concrete, the dismantling concrete is recyclable as aggregate for industry including nuclear field. Authors developed techniques on high quality aggregate reclamation for large amount of concrete generated during NPP decommissioning. Concrete of NPP buildings has good features for recycling aggregate; large quantity of high quality aggregate from same origin, record keeping of the aggregate origin, and little impurities in dismantled concrete such as wood and plastics. The target of recycled aggregate in this development is to meet the quality criteria for NPP concrete as prescribed in JASS 5N 'Specification for Nuclear Power Facility Reinforced Concrete' and JASS 5 'Specification for Reinforced Concrete Work'. The target of recycled aggregate concrete is to be comparable performance with ordinary aggregate concrete. The high quality recycled aggregate production techniques are assumed to apply for recycling for large amount of non-contaminated concrete. These techniques can also be applied for slightly contaminated concrete dismantled from radiological control area (RCA), together with free release survey. In conclusion: a technology on dismantled concrete recycling for high quality aggregate was developed

  3. Establishment of control site baseline data for erosion studies using radionuclides: a case study in East Slovenia

    Energy Technology Data Exchange (ETDEWEB)

    Mabit, Lionel, E-mail: L.Mabit@iaea.or [Soil Science Unit, FAO/IAEA Agriculture and Biotechnology Laboratory, IAEA Laboratories Seibersdorf, PO Box 100, Wagramerstrasse 5, A-1400 Vienna (Austria); Martin, Paul [Physics, Chemistry and Instrumentation Laboratory, IAEA Laboratories Seibersdorf, PO Box 100, Wagramerstrasse 5, A-1400 Vienna (Austria); Jankong, Patcharin; Toloza, Arsenio [Soil Science Unit, FAO/IAEA Agriculture and Biotechnology Laboratory, IAEA Laboratories Seibersdorf, PO Box 100, Wagramerstrasse 5, A-1400 Vienna (Austria); Padilla-Alvarez, Roman [Physics, Chemistry and Instrumentation Laboratory, IAEA Laboratories Seibersdorf, PO Box 100, Wagramerstrasse 5, A-1400 Vienna (Austria); Zupanc, Vesna [Department of Agronomy, Biotechnical Faculty, University of Ljubljana (Slovenia)

    2010-10-15

    The aim of the present study was to establish a reference site and its soil characteristics for use of fallout radionuclides in erosion studies in Slovenia. Prior to this study, no reference site and baseline data existed for Slovenia for this purpose. In the agricultural area of Goricko in East Slovenia, an undisturbed forest situated in Salamenci (46{sup o}44'N, 16{sup o}7'E), was selected to establish the inventory value of fallout {sup 137}Cs and to establish a baseline level of multi-elemental fingerprint (major, minor, trace elements including heavy metals) and naturally occurring radionuclides in soils. A total of 20 soil profiles were collected at four 10 cm depth increments for evaluation of baseline level of {sup 137}Cs inventory. An exponential distribution for {sup 137}Cs was found and the baseline level inventory was established at 7300 {+-} 2500 Bq m{sup -2} with a coefficient of variation of 34%. Of this mean present-day inventory, approximately 45% is due to the Chernobyl contribution. The physical degradation of soils through erosion is linked with biochemical degradation. This study introduces an approach to establishment of the naturally occurring radionuclide and elemental fingerprints baseline levels at a reference site which can provide comparative data to those from neighbouring agricultural fields for assessment of soil redistribution magnitude using fallout radionuclides. In addition, this information will be used to determine the impact of soil erosion processes and agricultural practices on soil quality and redistribution within agricultural landscapes in Slovenia.

  4. The adaptation study of the Q-sport-14 scale for the private sport establishments

    Directory of Open Access Journals (Sweden)

    Mehmet ÖZTÜRK

    2016-03-01

    Full Text Available Aim: The objective of this study is to adapt the “Q-SPORT 14” scale which is a tool to measure service quality for the private sport establishments. Material and Methods: The “Q-SPORT 10” scale, developed by Rial et al. (2010, reliability and validity study was conducted by Yıldız (2011 and adapted in Turkish, was used as data gathering tool. Total 585 scales were distributed to the participants and were withdrawn. The researcher ignored 103 of them due to incomplete marking. In the study, factor analysis, the rotated components matrix test, KMO and Barlet sphericity test, and the anti-image correlation test and reliability analaysis were used. The significance level was p<0.05 and the confidence interval was 95%. Results: KMO test was performed for the suitability of the sample size and it was 0.905. Bartlett sphericity test score was significant (p <0.01. The total variance description exposed 2 factors that Eigenvalues were higher than 1 and contributions to variance of these factors are 55%. After rotated components matrix analysis two sub-dimensions were identified (higher greater than 0.5; 9 items were related to "program and instructor quality" and the rest 5 items were related to “the physical environment and quality of equipment." The anti-image correlation presented that all items were higher than 0.5 All scores were more higher than 0.3 in the corrected item-total correlation and higher than 0.7 in Cronbach's alpha when item deleted. Conclusion: Q-SPORT 14 scale is highly reliable and usable measurement tool to test service quality in private sport establishments.

  5. A Narrative Review of High-Quality Literature on the Effects of Resident Duty Hours Reforms.

    Science.gov (United States)

    Lin, Henry; Lin, Emery; Auditore, Stephanie; Fanning, Jon

    2016-01-01

    To summarize current high-quality studies evaluating the effect and efficacy of resident duty hours reforms (DHRs) on patient safety and resident education and well-being. The authors searched PubMed and Medline in August 2012 and again in May 2013 for literature (1987-2013) about the effects of DHRs. They assessed the quality of articles using the Medical Education Research Study Quality Instrument (MERSQI) scoring system. They considered randomized controlled trials (RCTs), partial RCTs, and all studies with a MERSQI score ≥ 14 to be "high-quality" methodology studies. A total of 72 high-quality studies met inclusion criteria. Most studies showed no change or slight improvement in mortality and complication rates after DHRs. Resident well-being was generally improved, but there was a perceived negative impact on education (knowledge acquisition, skills, and cognitive performance) following DHRs. Eleven high-quality studies assessed the impact of DHR interventions; all reported a neutral to positive impact. Seven high-quality studies assessed costs associated with DHRs and demonstrated an increase in hospital costs. The results of most studies that allow enough time for DHR interventions to take effect suggest a benefit to patient safety and resident well-being, but the effect on the quality of training remains unknown. Additional methodologically sound studies on the impact of DHRs are necessary. Priorities for future research include approaches to optimizing education and clinical proficiency and studies on the effect of intervention strategies on both education and patient safety. Such studies will provide additional information to help improve duty hours policies.

  6. 18 CFR 347.1 - Material to support request for newly established or changed property account depreciation studies.

    Science.gov (United States)

    2010-04-01

    ... request for newly established or changed property account depreciation studies. 347.1 Section 347.1... REGULATIONS UNDER THE INTERSTATE COMMERCE ACT OIL PIPELINE DEPRECIATION STUDIES § 347.1 Material to support request for newly established or changed property account depreciation studies. (a) Means of filing...

  7. High quality protein microarray using in situ protein purification

    Directory of Open Access Journals (Sweden)

    Fleischmann Robert D

    2009-08-01

    Full Text Available Abstract Background In the postgenomic era, high throughput protein expression and protein microarray technologies have progressed markedly permitting screening of therapeutic reagents and discovery of novel protein functions. Hexa-histidine is one of the most commonly used fusion tags for protein expression due to its small size and convenient purification via immobilized metal ion affinity chromatography (IMAC. This purification process has been adapted to the protein microarray format, but the quality of in situ His-tagged protein purification on slides has not been systematically evaluated. We established methods to determine the level of purification of such proteins on metal chelate-modified slide surfaces. Optimized in situ purification of His-tagged recombinant proteins has the potential to become the new gold standard for cost-effective generation of high-quality and high-density protein microarrays. Results Two slide surfaces were examined, chelated Cu2+ slides suspended on a polyethylene glycol (PEG coating and chelated Ni2+ slides immobilized on a support without PEG coating. Using PEG-coated chelated Cu2+ slides, consistently higher purities of recombinant proteins were measured. An optimized wash buffer (PBST composed of 10 mM phosphate buffer, 2.7 mM KCl, 140 mM NaCl and 0.05% Tween 20, pH 7.4, further improved protein purity levels. Using Escherichia coli cell lysates expressing 90 recombinant Streptococcus pneumoniae proteins, 73 proteins were successfully immobilized, and 66 proteins were in situ purified with greater than 90% purity. We identified several antigens among the in situ-purified proteins via assays with anti-S. pneumoniae rabbit antibodies and a human patient antiserum, as a demonstration project of large scale microarray-based immunoproteomics profiling. The methodology is compatible with higher throughput formats of in vivo protein expression, eliminates the need for resin-based purification and circumvents

  8. An Improved Estimation of Regional Fractional Woody/Herbaceous Cover Using Combined Satellite Data and High-Quality Training Samples

    Directory of Open Access Journals (Sweden)

    Xu Liu

    2017-01-01

    Full Text Available Mapping vegetation cover is critical for understanding and monitoring ecosystem functions in semi-arid biomes. As existing estimates tend to underestimate the woody cover in areas with dry deciduous shrubland and woodland, we present an approach to improve the regional estimation of woody and herbaceous fractional cover in the East Asia steppe. This developed approach uses Random Forest models by combining multiple remote sensing data—training samples derived from high-resolution image in a tailored spatial sampling and model inputs composed of specific metrics from MODIS sensor and ancillary variables including topographic, bioclimatic, and land surface information. We emphasize that effective spatial sampling, high-quality classification, and adequate geospatial information are important prerequisites of establishing appropriate model inputs and achieving high-quality training samples. This study suggests that the optimal models improve estimation accuracy (NMSE 0.47 for woody and 0.64 for herbaceous plants and show a consistent agreement with field observations. Compared with existing woody estimate product, the proposed woody cover estimation can delineate regions with subshrubs and shrubs, showing an improved capability of capturing spatialized detail of vegetation signals. This approach can be applicable over sizable semi-arid areas such as temperate steppes, savannas, and prairies.

  9. Who gets the benefits of geopark establishment? A study of Batur Geopark Area, Bali Province, Indonesia

    Science.gov (United States)

    Sagala, S.; Rosyidie, A.; Sasongko, M. A.; Syahbid, M. M.

    2018-05-01

    As an important contributor to the improvement of economic and social aspects within communities, tourism is a sector whose development must be paid careful attention to. Tourist attractions, especially for nature based tourism, have been proven to provide employment and a significant contribution to both the GDP and GNP of Indonesia. Various areas in Indonesia have natural tourist attractions. A recent popular type of natural tourism attraction in Indonesia are geoparks, which involve protection and utilization of wide geological heritage areas. One of the geoparks that have been recognized by UNESCO within its Global Geopark Network (GGN) is Batur Geopark, in the province of Bali, Indonesia. The development of a geopark should consider the local economic development within its surrounding area. In addition, the further development of a geopark area that is included within the Global Geopark Network must meet the criteria for social and economic aspects prepared by UNESCO. The establishment of these criteria is intended to ensure that the management of the geopark is also beneficiary for the development of local communities as well as contribute positively to their sustainable development. Indonesia has a number of initiatives to promote the establishment of new geoparks, such as Geopark Merangin, Geopark Ciletuh and Geopark Sewu. The most recent one to be considered is Toba Lake Area. Therefore, taking lessons learned from an existing geopark regarding its economic impacts is important. This study explored the positive and negative impacts of Batur Geopark on the local economic development of its surrounding area after its inclusion in the Global Geopark Network of UNESCO. Further recommendations are and formulated in order to enhance the mutual linkage between tourism development and economic benefits to the communities. Prior to the analyses, a literature review on best practices of geoparks was done. Qualitative analyses were conducted by interviewing 41

  10. A study on emergency preparedness for nuclear power plant/ Establishment of emergency communication network system

    International Nuclear Information System (INIS)

    Yang, Y. K.; Jung, Y. D.; Kim, S. Y.

    1991-12-01

    The objective of this study was to develop an emergency database search system for nuclear power plants during nuclear incidents / accidents. Image data reported from nuclear power plants to the regulatory body and other related data will be stored systematically in the computer. The data will be utilized during nuclear emergency to prevent the accident from spreading out and to minimize its effect. It will also be used in exchanging information on accident or incidents with the foreign countries. The operational documents in the Kori-4 nuclear power plant are used as the major source for the categorization and analysis in performing this research. It was not easy to access the detailed operational data due to its unique characteric for the security. Therefore, we strongly suggest to increase manpower for this project in Korea Institute of Nuclear Safety (KINS) and archive involvement from Korea Electric Power Company to establish better database retrieval system

  11. A study on emergency preparedness for nuclear power plant/ Establishment of emergency communication network system

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Y K; Jung, Y D; Kim, S Y [Korea Institute of Science and Technology, Seoul (Korea, Republic of)

    1991-12-15

    The objective of this study was to develop an emergency database search system for nuclear power plants during nuclear incidents / accidents. Image data reported from nuclear power plants to the regulatory body and other related data will be stored systematically in the computer. The data will be utilized during nuclear emergency to prevent the accident from spreading out and to minimize its effect. It will also be used in exchanging information on accident or incidents with the foreign countries. The operational documents in the Kori-4 nuclear power plant are used as the major source for the categorization and analysis in performing this research. It was not easy to access the detailed operational data due to its unique characteric for the security. Therefore, we strongly suggest to increase manpower for this project in Korea Institute of Nuclear Safety (KINS) and archive involvement from Korea Electric Power Company to establish better database retrieval system.

  12. A study on the establishment of strengthened infrastructures for bilateral nuclear cooperation

    International Nuclear Information System (INIS)

    Choi, Pyung Hoon; Jung, Jun Keuk; Shim, Jae Sun; Kim, Myug Ro; Seo, Min Won; Lee, Jeong Kong

    2001-12-01

    The objectives of this study are to look into and analyze the current status of international cooperation activities so far conducted, especially focused on the Joint Standing Committees on Nuclear Energy Cooperation which have served as channels of dialogue for promoting nuclear cooperation between Korea and the counterpart countries, to present the identified problems to be addressed and to come up with appropriate measures to actively and effectively participate in international nuclear cooperation activities in the future by nuclear-related industries, academia and institute with the aim of establishing a firm foundation for implementing more systematic cooperation while the government takes lead. Further, effective and systematic implementation of nuclear bilateral cooperation through full participation of industries, academia and institutes will contribute to national development by advancing nuclear technology

  13. A study for the development of a vegetable planter for Optimum stand establishment

    International Nuclear Information System (INIS)

    Zaidi, M.A.; Amjad, N.; Shah, S.U.S

    2013-01-01

    Seed placement and establishment is probably the most crucial phase in the life of a vegetable crop, therefore, the role of the planter or seeder is of vital importance. The objective of this study was to assess the demand of a vegetable planter/seeder and to collect information from farmers, machinery manufacturers and stakeholders to design a new planter for vegetables, initially for pea crop. To achieve the objective of this study, a survey was conducted in three provinces (Punjab, Sindh and Baluchistan) of the country and 34 farmers, 21 officers from the concerned institutions and 14 manufactures were interviewed. Furthermore, three existing planters/drills used for sowing different crops were picked from different sources for evaluating their comparative performance for planting pea. The status of vegetable planting or sowing as a whole was not found encouraging in the country and most vegetables are grown manually that are time consuming and labour intensive practices. Farmers are vigorously demanding a planter or seeder for vegetables. From the evaluation of existing machines, it was concluded that a pneumatic planter for sowing vegetables on beds is the most precise method that drops 10 to 20 seeds per meter length at recommended forward speed with single seed placement per hill. This ensures not only the optimum seed rate, but also eliminates the need for thinning after germination. Using this machine farmers may be able to save two third of the seed quantity for pea crop together with achieving additional benefits of vegetables mechanisation. Therefore, a vegetable planter, initially for pea, should be developed locally to enhance productivity of vegetables, because root establishment of vegetable crops is very critical factor that affects ultimate yield. (author)

  14. Establishment of feline intestinal epithelial cell cultures for the propagation and study of feline enteric coronaviruses

    Science.gov (United States)

    2013-01-01

    Feline infectious peritonitis (FIP) is the most feared infectious cause of death in cats, induced by feline infectious peritonitis virus (FIPV). This coronavirus is a virulent mutant of the harmless, ubiquitous feline enteric coronavirus (FECV). To date, feline coronavirus (FCoV) research has been hampered by the lack of susceptible cell lines for the propagation of serotype I FCoVs. In this study, long-term feline intestinal epithelial cell cultures were established from primary ileocytes and colonocytes by simian virus 40 (SV40) T-antigen- and human Telomerase Reverse Transcriptase (hTERT)-induced immortalization. Subsequently, these cultures were evaluated for their usability in FCoV research. Firstly, the replication capacity of the serotype II strains WSU 79–1683 and WSU 79–1146 was studied in the continuous cultures as was done for the primary cultures. In accordance with the results obtained in primary cultures, FCoV WSU 79–1683 still replicated significantly more efficient compared to FCoV WSU 79–1146 in both continuous cultures. In addition, the cultures were inoculated with faecal suspensions from healthy cats and with faecal or tissue suspensions from FIP cats. The cultures were susceptible to infection with different serotype I enteric strains and two of these strains were further propagated. No infection was seen in cultures inoculated with FIPV tissue homogenates. In conclusion, a new reliable model for FCoV investigation and growth of enteric field strains was established. In contrast to FIPV strains, FECVs showed a clear tropism for intestinal epithelial cells, giving an explanation for the observation that FECV is the main pathotype circulating among cats. PMID:23964891

  15. Fabricating High-Quality 3D-Printed Alloys for Dental Applications

    Directory of Open Access Journals (Sweden)

    Min-Ho Hong

    2017-07-01

    Full Text Available Metal additive manufacturing (AM, especially selective laser melting (SLM, has been receiving particular attention because metallic functional structures with complicated configurations can be effectively fabricated using the technique. However, there still exist some future challenges for the fabrication of high-quality SLM products for dental applications. First, the surface quality of SLM products should be further improved by standardizing the laser process parameters or by appropriately post-treating the surface. Second, it should be guaranteed that dental SLM restorations have good dimensional accuracy and, in particular, a good marginal fit. Third, a definitive standard regarding building and scanning strategies, which affect the anisotropy, should be established to optimize the mechanical properties and fatigue resistance of SLM dental structures. Fourth, the SLM substructure’s bonding and support to veneering ceramic should be further studied to facilitate the use of esthetic dental restorations. Finally, the biocompatibility of SLM dental alloys should be carefully examined and improved to minimize the potential release of toxic metal ions from the alloys. Future research of SLM should focus on solving the above challenges, as well as on fabricating dental structures with “controlled” porosity.

  16. A preliminary study on using manufactured sand from Jelsa Quarry for the production of plastic concrete mixes. FA 2 Competitive constructions. SP 2.3 High quality manufactured sand for concrete

    OpenAIRE

    Cepuritis, Rolands

    2012-01-01

    This study has been carried out within COIN - Concrete Innovation Centre - one of presently 14 Centres for Research based Innovation (CRI), which is an initiative by the Research Council of Norway. 3D005940

  17. Establishing multiple omics baselines for three Southeast Asian populations in the Singapore Integrative Omics Study.

    Science.gov (United States)

    Saw, Woei-Yuh; Tantoso, Erwin; Begum, Husna; Zhou, Lihan; Zou, Ruiyang; He, Cheng; Chan, Sze Ling; Tan, Linda Wei-Lin; Wong, Lai-Ping; Xu, Wenting; Moong, Don Kyin Nwe; Lim, Yenly; Li, Bowen; Pillai, Nisha Esakimuthu; Peterson, Trevor A; Bielawny, Tomasz; Meikle, Peter J; Mundra, Piyushkumar A; Lim, Wei-Yen; Luo, Ma; Chia, Kee-Seng; Ong, Rick Twee-Hee; Brunham, Liam R; Khor, Chiea-Chuen; Too, Heng Phon; Soong, Richie; Wenk, Markus R; Little, Peter; Teo, Yik-Ying

    2017-09-21

    The Singapore Integrative Omics Study provides valuable insights on establishing population reference measurement in 364 Chinese, Malay, and Indian individuals. These measurements include > 2.5 millions genetic variants, 21,649 transcripts expression, 282 lipid species quantification, and 284 clinical, lifestyle, and dietary variables. This concept paper introduces the depth of the data resource, and investigates the extent of ethnic variation at these omics and non-omics biomarkers. It is evident that there are specific biomarkers in each of these platforms to differentiate between the ethnicities, and intra-population analyses suggest that Chinese and Indians are the most biologically homogeneous and heterogeneous, respectively, of the three groups. Consistent patterns of correlations between lipid species also suggest the possibility of lipid tagging to simplify future lipidomics assays. The Singapore Integrative Omics Study is expected to allow the characterization of intra-omic and inter-omic correlations within and across all three ethnic groups through a systems biology approach.The Singapore Genome Variation projects characterized the genetics of Singapore's Chinese, Malay, and Indian populations. The Singapore Integrative Omics Study introduced here goes further in providing multi-omic measurements in individuals from these populations, including genetic, transcriptome, lipidome, and lifestyle data, and will facilitate the study of common diseases in Asian communities.

  18. A study on the establishment of habitability requirement for enviromental laboratory in nuclear emergency

    International Nuclear Information System (INIS)

    Khang, Byung Oui

    2003-01-01

    The Establishment of the habitability requirement for Environmental Laboratory (EL) was required to decide the time of movement to a backup EL. The habitability criteria of the EL located inside plum pathway emergency planning zone was established including the alarm setpoint of the area radiation monitor based on the operational intervention level recommended by IAEA. The MDA of analysis equipments were established based on the generic action level recommended by IAEA. The countermeasures for the loss of habitability of EL was established by defined the emergency response activity at EL in nuclear emergency

  19. Learning Disabilities and Achieving High-Quality Education Standards

    Science.gov (United States)

    Gartland, Debi; Strosnider, Roberta

    2017-01-01

    This is an official document of the National Joint Committee on Learning Disabilities (NJCLD), of which Council for Learning Disabilities is a long-standing, active member. With this position paper, NJCLD advocates for the implementation of high-quality education standards (HQES) for students with learning disabilities (LD) and outlines the…

  20. extraction of high quality dna from polysaccharides-secreting ...

    African Journals Online (AJOL)

    cistvr

    A DNA extraction method using CTAB was used for the isolation of genomic DNA from ten. Xanthomonas campestris pathovars, ten isolates of Xanthomonas albilineans and one isolate of. Pseudomonas rubrisubalbicans. High quality DNA was obtained that was ideal for molecular analy- ses. Extracellular polysaccharides ...

  1. Negative Binomial charts for monitoring high-quality processes

    NARCIS (Netherlands)

    Albers, Willem/Wim

    Good control charts for high quality processes are often based on the number of successes between failures. Geometric charts are simplest in this respect, but slow in recognizing moderately increased failure rates p. Improvement can be achieved by waiting until r > 1 failures have occurred, i.e. by

  2. Adoption and impact of high quality bambara flour (HQBF ...

    African Journals Online (AJOL)

    Adoption and impact of high quality bambara flour (HQBF) technology in the ... consumer acceptability/quality of products, credit, availability of raw materials, and ... as a result of 12.5 per cent increase in demand for bambara-based products.

  3. A Study on Establishment of Unacceptable Radiological Consequence (URC) for Physical Protection against Sabotage

    Energy Technology Data Exchange (ETDEWEB)

    Jung, Myungtak; Koh, Moonsung; Lee, Youngwook; Jo, Kwang Ho [Korea Institute of Nuclear Nonproliferation and Control, Daejeon (Korea, Republic of)

    2014-05-15

    The international community has recommended that a graded approach should be applied to the establishment of the domestic regime for physical protection in accordance with fundamental principle H of the amended Convention on Physical Protection of Nuclear Material (CPPNM) and INFCIRC/225/rev.5. In Korea, Currently, the graded approach to unauthorized removal of nuclear material is divided into three categories (Category Ι, Category ΙΙ, Category ΙΙΙ) based on the IAEA INFCIRC/225/rev.5. Moreover, depending on the categorization of nuclear material, physical protection measures against unauthorized removal are also clearly categorized. But in the case of physical protection against sabotage, the graded approach to the physical protection measures is not applied since Unacceptable Radiological Consequence (URC) for identifying sabotage target and level is not determined. URC can be established based on either dose limit or design limit. The report by Sandia National Lab. in USA specifies that core damage is used for URC. Calculation of an exact dose is based on various assumptions and processes and subsequently increases uncertainty. Therefore, using design limit for decreasing uncertainty is more effective than using dose limit. In order to apply the graded approach to physical protection against sabotage, we have taken into Fundamental principle H : Physical protection requirements should be based on a graded approach, taking into account the current evaluation of the threat, the relative attractiveness, the nature of the material and potential consequences associated with the unauthorized removal of nuclear material and with the sabotage against nuclear material of nuclear facilities consideration legal and institutional standards on domestic and international radiological consequences and intended to provide a reference for the URC establishment by the State. The study on various standards led to the conclusion that each value has advantages and

  4. High-quality endoscope reprocessing decreases endoscope contamination.

    Science.gov (United States)

    Decristoforo, P; Kaltseis, J; Fritz, A; Edlinger, M; Posch, W; Wilflingseder, D; Lass-Flörl, C; Orth-Höller, D

    2018-02-24

    Several outbreaks of severe infections due to contamination of gastrointestinal (GI) endoscopes, mainly duodenoscopes, have been described. The rate of microbial endoscope contamination varies dramatically in literature. The aim of this multicentre prospective study was to evaluate the hygiene quality of endoscopes and automated endoscope reprocessors (AERs) in Tyrol/Austria. In 2015 and 2016, a total of 463 GI endoscopes and 105 AERs from 29 endoscopy centres were analysed by a routine (R) and a combined routine and advanced (CRA) sampling procedure and investigated for microbial contamination by culture-based and molecular-based analyses. The contamination rate of GI endoscopes was 1.3%-4.6% according to the national guideline, suggesting that 1.3-4.6 patients out of 100 could have had contacts with hygiene-relevant microorganisms through an endoscopic intervention. Comparison of R and CRA sampling showed 1.8% of R versus 4.6% of CRA failing the acceptance criteria in phase I and 1.3% of R versus 3.0% of CRA samples failing in phase II. The most commonly identified indicator organism was Pseudomonas spp., mainly Pseudomonas oleovorans. None of the tested viruses were detected in 40 samples. While AERs in phase I failed (n = 9, 17.6%) mainly due to technical faults, phase II revealed lapses (n = 6, 11.5%) only on account of microbial contamination of the last rinsing water, mainly with Pseudomonas spp. In the present study the contamination rate of endoscopes was low compared with results from other European countries, possibly due to the high quality of endoscope reprocessing, drying and storage. Copyright © 2018 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

  5. Emotional Experience, Expression, and Regulation of High-Quality Japanese Elementary School Teachers

    Science.gov (United States)

    Hosotani, Rika; Imai-Matsumura, Kyoko

    2011-01-01

    The present study investigates the emotional experience, expression, and regulation processes of high-quality Japanese elementary school teachers while they interact with children, in terms of teachers' emotional competence. Qualitative analysis of interview data demonstrated that teachers had various emotional experiences including self-elicited…

  6. Student Writing Accepted as High-Quality Responses to Analytic Text-Based Writing Tasks

    Science.gov (United States)

    Wang, Elaine; Matsumura, Lindsay Clare; Correnti, Richard

    2018-01-01

    Literacy standards increasingly emphasize the importance of analytic text-based writing. Little consensus exists, however, around what high-quality student responses should look like in this genre. In this study, we investigated fifth-grade students' writing in response to analytic text-based writing tasks (15 teachers, 44 writing tasks, 88 pieces…

  7. Optimization of nitridation conditions for high quality inter-polysilicon dielectric layers

    NARCIS (Netherlands)

    Klootwijk, J.H.; Bergveld, H.J.; van Kranenburg, H.; Woerlee, P.H.; Wallinga, Hans

    1996-01-01

    Nitridation of deposited high temperature oxides (HTO) was studied to form high quality inter-polysilicon dielectric layers for embedded non volatile memories. Good quality dielectric layers were obtained earlier by using an optimized deposition of polysilicon and by performing a post-dielectric

  8. From journal to headline: the accuracy of climate science news in Danish high quality newspapers

    DEFF Research Database (Denmark)

    Vestergård, Gunver Lystbæk

    2011-01-01

    analysis to examine the accuracy of Danish high quality newspapers in quoting scientific publications from 1997 to 2009. Out of 88 articles, 46 contained inaccuracies though the majority was found to be insignificant and random. The study concludes that Danish broadsheet newspapers are ‘moderately...

  9. Emblems of Quality in Higher Education. Developing and Sustaining High-Quality Programs.

    Science.gov (United States)

    Haworth, Jennifer Grant; Conrad, Clifton F.

    This book proposes an "engagement" theory of program quality to evaluate and improve higher education programs at all degree levels. Based on interviews with 781 participants in a national study of Masters degree programs, it focuses on the interactive roles of students, faculty, and administrators in developing high-quality programs…

  10. Establishment of atherosclerotic model and USPIO enhanced MRI techniques study in rabbits

    International Nuclear Information System (INIS)

    Li Yonggang; Zhu Mo; Dai Yinyu; Chen Jianhua; Guo Liang; Ni Jiankun

    2010-01-01

    Objective: To explore the methods of establishment of atherosclerotic model and USPIO enhanced MRI techniques in rabbits. Methods: Thirty New Zealand male rabbits were divided randomly into two groups: 20 animals in the experiment group, 10 animals in the control group. Animal model of atherosclerosis was induced with aortic balloon endothelial injury and high-fat diet feeding. There was no intervention with the rabbits in control group. MRI examination included plan scan, USPIO enhanced black-blood sequences and white-blood sequence. The features of the plaques was analyzed in the experimental group and the effection on the image quality of different coils, sequences and parameters and a statistical study was also analyzed. Results: Animal model of atherosclerosis was successfully made in 12 rabbits and most plaques located in the abdomen aorta. There were 86 plaques within the scanning scope among which 67 plaques were positive to the Prussian blue staining. The image quality of knee joint coil was better than that of other coils. Although there was no difference in the detection of numbers of AS plaques between USPIO enhanced black-blood sequences and white-blood sequence (P > 0.05), blackblood sequences was superior to white-blood sequence in the demonstration of the components of plaque. Conclusion: The method of aortic balloon endothelial injury and high-fat diet feeding can easily establish the AS model in rabbits with a shorter period and it may be used for controlling the location of the plaques. USPIO enhanced MRI sequences has high sensitivity in the detection of the AS plauqes and can reveal the component of AS plaques. The optimization of MRI techniques is very important in the improvement of the image quality and the detection of the plaques. (authors)

  11. Strategies for establishing networking with partner schools for implementing lesson study in Indonesia

    Directory of Open Access Journals (Sweden)

    Nurwidodo Nurwidodo

    2018-03-01

    Full Text Available Lesson Study for Learning Community (LSLC contains two terminologies underpinning one another. There are many difficult challenges when the plan to create LSLC surfaces. Therefore, strong motivation and precise implementation strategies are of urgency. One of the ways is by developing networking of LSLC between universities and partner schools. The LSLC program will become powerful when it is done collaboratively in a form of strong partnership connected by networks. Writing this article aims to describe strategies for establishing networking with partner schools for implementing lesson study in Indonesia. This review article uses literature comparison study methods and use content analysis. In order for LSLC to manifest and become successful, resourcing and utilizing the partnership with schools are required. In a partnership with schools in order to implement LSLC, both parties must share the same need, which is facing the challenge with the willingness to cooperate for solving the problem. Cooperation with partner schools needs to be nurtured to become networking so that the benefits and the spirit of cooperation in solving problem double fold. Networking with partner schools can be implemented and can function well when the management of this networking conforms to shared needs, nurtures cooperation and mutual respect, gives and takes equally, and also promotes fair acceptance, support, independence, and discipline.

  12. Determinants attributes in purchase decision: a study in establishments commercialize street food

    Directory of Open Access Journals (Sweden)

    Hannah Nicchio Loriato

    2017-01-01

    Full Text Available The attributes of a product can vary greatly in the importance they have for different consumers, and from the idea that there are different degrees of importance in relation to the attributes and importance that influence the buying decision. The purpose of this study is to identify which attributes are crucial for consumers in making buying decisions in establishments that sell street food. It is a study of both qualitative and quantitative nature. In the qualitative phase was conducted semi-structured interviews with 16 customers and analyzed using content analysis.It was carried out one survey, applying 200 questionnaires, to survey data for quantitative phase . The analysis of this quantitative phase was carried out using Excel and SPSS, with the use of multivariate statistical techniques. The results indicated that the service offered is the construct considered crucial to the customers' buying decision. In addition, this study enables the spread of this research scope in the country and contributes to the entrepreneurs in the street food sector seeking strategies to keep themselves firmly in the market.

  13. Case Studies of Community-Academic Partnerships Established Using the Give-Get Grid Model.

    Science.gov (United States)

    Behringer, Bruce; Southerland, Jodi L; Plummer, Robert M

    2017-11-01

    While partnerships for health delivery and improvement are frequently described by their structure, goals, and plans, less attention is paid to the interactive relationships among partners or for larger stakeholder groups' coalition memberships. The Give-Get Grid group process tool can be used to assess each stakeholders' expected benefits ("gets") and contributions ("gives") needed to establish and maintain long-term, mutually advantageous community-academic partnerships. This article describes three case study experiences using the Give-Get Grid in real-world context to understand and generate ideas to address contemporary health promotion opportunities among a variety of stakeholders. The case studies address three distinct community health promotion opportunities: prevention of school-based adolescent obesity disparities, higher education health professions training programs in rural community-based settings, and methods for engaging community coalitions in state Comprehensive Cancer Control Programs. The case studies demonstrate the Give-Get Grid's utility in both planning and evaluating partnerships and documenting key elements for progress in health promotion initiatives built on long-term community-academic relationships. Steps are explained with practical lessons learned in using the Grid.

  14. Establishing post mortem criteria for the metabolic syndrome: an autopsy based cross-sectional study.

    Science.gov (United States)

    Christensen, Martin Roest; Bugge, Anne; Malik, Mariam Elmegaard; Thomsen, Jørgen Lange; Lynnerup, Niels; Rungby, Jørgen; Banner, Jytte

    2018-01-01

    Individuals who suffer from mental illness are more prone to obesity and related co-morbidities, including the metabolic syndrome. Autopsies provide an outstanding platform for the macroscopic, microscopic and molecular-biological investigation of diseases. Autopsy-based findings may assist in the investigation of the metabolic syndrome. To utilise the vast information that an autopsy encompasses to elucidate the pathophysiology behind the syndrome further, we aimed to both develop and evaluate a method for the post mortem definition of the metabolic syndrome. Based on the nationwide Danish SURVIVE study of deceased mentally ill, we established a set of post mortem criteria for each of the harmonized criteria of the metabolic syndrome. We based the post mortem (PM) evaluation on information from the police reports and the data collected at autopsy, such as anthropometric measurements and biochemical and toxicological analyses (PM information). We compared our PM evaluation with the data from the Danish health registries [ante mortem (AM) information, considered the gold standard] from each individual. The study included 443 deceased individuals (272 male and 171 female) with a mean age of 50.4 (± 15.5) years and a median (interquartile range) post mortem interval of 114 (84-156) hours. We found no significant difference when defining the metabolic syndrome from the PM information in comparison to the AM information ( P  = 0.175). The PM evaluation yielded a high specificity (0.93) and a moderate sensitivity (0.63) with a moderate level of agreement compared to the AM evaluation (Cohen's κ = 0.51). Neither age nor post mortem interval affected the final results. Our model of a PM definition of the metabolic syndrome proved reliable when compared to the AM information. We believe that an appropriate estimate of the prevalence of the metabolic syndrome can be established post mortem. However, while neither the PM nor the AM information is exhaustive in

  15. Relationship between Tree Value, Diameter, and Age in High-Quality Sugar Maple (Acer saccharum) on the Menominee Reservation, Wisconsin

    Science.gov (United States)

    Daniel C. Dey; John Dwyer; Jan Wiedenbeck

    2017-01-01

    Guidelines for managing sugar maple-dominated forests by the single-tree selection method are well established and widely adopted. The forests of the Menominee Tribe in Wisconsin provide an opportunity to validate current guidelines by testing tree value and size/age relationships in forests that have substantially older and larger high-quality trees than can be found...

  16. Using Early Learning Standards to Provide High-Quality Education for All Children: The Early Learning Guidelines Toolkit

    Science.gov (United States)

    Flores, Roseanne L.; Curby, Timothy W.; Coleman, Hardin; Melo, Kristan

    2016-01-01

    Today with the rise in the number of 3- to 6-year-old children enrolled in center-based early childhood programs, and a focus on program quality, it becomes imperative for educators to have a better understanding of the role research plays in establishing high-quality programs as these programs provide much of the foundation that supports early…

  17. Establishment of an Italian chronic migraine database: a multicenter pilot study.

    Science.gov (United States)

    Barbanti, Piero; Fofi, L; Cevoli, S; Torelli, P; Aurilia, C; Egeo, G; Grazzi, L; D'Amico, D; Manzoni, G C; Cortelli, P; Infarinato, F; Vanacore, N

    2018-05-01

    To optimize chronic migraine (CM) ascertainment and phenotype definition, provide adequate clinical management and health care procedures, and rationalize economic resources allocation, we performed an exploratory multicenter pilot study aimed at establishing a CM database, the first step for developing a future Italian CM registry. We enrolled 63 consecutive CM patients in four tertiary headache centers screened with face-to-face interviews using an ad hoc dedicated semi-structured questionnaire gathering detailed information on life-style, behavioral and socio-demographic factors, comorbidities, and migraine features before and after chronicization and healthcare resource use. Our pilot study provided useful insights revealing that CM patients (1) presented in most cases symptoms of peripheral trigeminal sensitization, a relatively unexpected feature which could be useful to unravel different CM endophenotypes and to predict trigeminal-targeted treatments' responsiveness; (2) had been frequently admitted to emergency departments; (3) had undergone, sometime repeatedly, unnecessary or inappropriate investigations; (4) got rarely illness benefit exemption or disability allowance only. We deem that the expansion of the database-shortly including many other Italian headache centers-will contribute to more precisely outline CM endophenotypes, hence improving management, treatment, and economic resource allocation, ultimately reducing CM burden on both patients and health system.

  18. Study on establishing database system for marine geological and geophysical data 1

    Energy Technology Data Exchange (ETDEWEB)

    Han, Hyun Chul; Bahng, Hyo Ky; Lee, Chi Won; Kang, Jung Seock; Chang, Se Won; Lee, Ho Young [Korea Inst. of Geology Mining and Materials, Taejon (Korea, Republic of); Park, Soo Chul [Chungnam National University, Taejon (Korea, Republic of)

    1995-12-01

    Most marine geological and geophysical data collected from the institutes of Korea are an analogue type, and stored in several data acquisition institutes according to their own data management systems and input formats. Thus, if someone wants to use the data, he must visit institute(s) to collect the data. It is also necessary to manipulate the collected data based on the user`s own data management system because data input formats differ from each institute. Consequently, it requires lots of time to do searching, managing and analyzing the data. The purpose of the study, therefore, is to establish database system for the standardization of the data input formats and to develop the data output conversion software for the commonly used database management system. Marine geological and geophysical data input formats are set up through the detailed analyses for the input formats used in the domestic as well as foreign countries. PC-based output conversion software for the bathymetry, gravity and magnetic data is also developed. Thus, if all institutes use the data input formats introduced in this study, it is possible to minimize the redundancy, to keep the consistency, and to make a standardization of data. (author). 6 refs., 22 figs., 10 tabs.

  19. Preliminary study for treatment methodology establishment of liquid waste containing uranium in refining facility lagoon

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Byung Jik; Lee, Kune Woo; Won, Hui Jun; Ahn, Byung Gil; Shim, Joon Bo

    1999-12-01

    The preliminary study which establishes the treatment methodology of the sludge waste containing uranium in the conversion facility lagoon was performed. The property of lagoon liquid waste such as the initial water content, the density including radiochemical analysis results were obtained using the samples taken from the lagoon. The objective of this study is to provide some basically needed materials for selection of the most proper lagoon waste treatment methodology by reviewing the effective processes and methods for minimizing the secondary waste resulting from the treatment and disposition of large amount of radioactive liquid waste according to the facility closing. The lagoon waste can be classified into two sorts, such as supernatant and precipitate. The supernatants contain uranium less than 5 ppm and their water content are about 35 percent. Therefore, supernatants are solutions composed of mainly salt components. However, the precipitates have lots of uranium compound contained in the coagulation matrix, and are formed as two kinds of crystalline structures. The most proper method minimizing the secondary waste would be direct drying and solidification of the supernatants and precipitates after separation of them by filtering. (author)

  20. Study on the establishment of corneal alkali chemical injury on rats

    Directory of Open Access Journals (Sweden)

    Nan Hu

    2013-06-01

    Full Text Available AIM:To investigate the appropriate methods to establish corneal alkali chemical injury on rats. METHODS:The rats(n=87were randomly divided into three groups. Corneal alkali injury was induced by placing 1mol/L NaOH soaked filter paper on the limbus of right cornea for 20 seconds(group A, n=34or 40 seconds(group B, n=23, and on the central axis of the right cornea for 40 seconds(group C, n=30respectively. Corneal transparency, corneal ulceration, and corneal neovascularization were observed and recorded under slit- lamp biomicroscope on day 7 post-operation. RESULTS: Incidence of corneal ulceration, corneal perforation and positive rate of corneal fluorescein staining in limbal corneal injury groups(group A and Bwere significantly higher than that of central corneal injury group(group C(P<0.05. Incidence of corneal ulceration and corneal perforation in group B was significantly higher than group A(P<0.05. Corneal neovascularization was observed in all three groups. CONCLUSION: Corneal alkali burns induced by 3mm diameter central cornea injury are fit for the study of corneal neovascularization, while those induced by limbus injury for 20 seconds are fit for the study on limbal stem cells deficiency.

  1. Data linkage in an established longitudinal cohort: the Western Australian Pregnancy Cohort (Raine) Study.

    Science.gov (United States)

    Mountain, Jenny A; Nyaradi, Anett; Oddy, Wendy H; Glauert, Rebecca A; de Klerk, Nick H; Straker, Leon M; Stanley, Fiona J

    2016-07-15

    The Western Australian Data Linkage System is one of a few comprehensive, population-based data linkage systems worldwide, creating links between information from different sources relating to the same individual, family, place or event, while maintaining privacy. The Raine Study is an established cohort study with more than 2000 currently active participants. Individual consent was obtained from participants for information in publicly held databases to be linked to their study data. A waiver of consent was granted where it was impracticable to obtain consent. Approvals to link the datasets were obtained from relevant ethics committees and data custodians. The Raine Study dataset was subsequently linked to academic testing data collected by the Western Australian Department of Education. Examination of diet and academic performance showed that children who were predominantly breastfed for at least 6 months scored higher academically at age 10 than children who were breastfed for less than 6 months. A further study found that better diet quality at ages 1, 2 and 3 years was associated with higher academic scores at ages 10 and 12 years. Examination of nutritional intake at 14 years of age found that a better dietary pattern was associated with higher academic performance. The detailed longitudinal data collected in the Raine Study allowed for adjustment for multiple covariates and confounders. Data linkage reduces the burden on cohort participants by providing additional information without the need to contact participants. It can give information on participants who have been lost to follow-up; provide or complement missing data; give the opportunity for validation studies comparing recall of participants with administrative records; increase the population sample of studies by adding control participants from the general population; and allow for the adjustment of multiple covariates and confounders. The Raine Study dataset is extensive and detailed, and can be

  2. Pay More Attention: a national mixed methods study to identify the barriers and facilitators to ensuring equal access to high-quality hospital care and services for children and young people with and without learning disabilities and their families.

    Science.gov (United States)

    Oulton, Kate; Wray, Jo; Carr, Lucinda; Hassiotis, Angela; Jewitt, Carey; Kerry, Sam; Tuffrey-Wijne, Irene; Gibson, Faith

    2016-12-09

    Despite evidence of health inequalities for adults with intellectual disability (ID) there has yet to be a comprehensive review of how well hospital services are meeting the needs of children and young people (CYP) with ID and their families. We do not know how relevant existing recommendations and guidelines are to CYP, whether these are being applied in the paediatric setting or what difference they are making. Evidence of parental dissatisfaction with the quality, safety and accessibility of hospital care for CYP with ID exists. However, the extent to which their experience differs from parents of CYP without ID is not known and the views and experiences of CYP with ID have not been investigated. We will compare how services are delivered to, and experienced by CYP aged 5-15 years with and without ID and their families to see what inequalities exist, for whom, why and under what circumstances. We will use a transformative, mixed methods case study design to collect data over four consecutive phases. We will involve CYP, parents and hospital staff using a range of methods; interviews, parental electronic diary, hospital and community staff questionnaire, patient and parent satisfaction questionnaire, content analysis of hospital documents and a retrospective mapping of patient hospital activity. Qualitative data will be managed and analysed using NVivo and quantitative data will be analysed using parametric and non-parametric descriptive statistics. The study will run from December 2015 to November 2018. We have Health Authority Approval (IRAS project ID: 193932) for phase 1 involving staff only and ethical and Health Authority Approval for phases 2-4 (IRAS project ID: 178525). We will disseminate widely to relevant stakeholders, using a range of accessible formats, including social media. We will publish in international peer-reviewed journals and present to professional, academic and lay audiences through national and international conferences. Published by

  3. A clinical study of dermatoses in diabetes to establish its markers

    Directory of Open Access Journals (Sweden)

    Dependra Kumar Timshina

    2012-01-01

    Full Text Available Background: Cutaneous manifestations of diabetes mellitus generally appear subsequent to the development of the disease, but they may be the first presenting signs and in some cases they may precede the primary disease manifestation by many years. Aims : T0 he aim of our study was to study the spectrum of dermatoses in diabetics, to know the frequency of dermatoses specific to diabetes mellitus (DM, and to establish the mucocutaneous markers of DM. Material and Methods: The study was conducted at a diabetic clinic and our department between September 2008 and June 2010. Two hundred and twenty-four diabetic patients were included in the study group and those with gestational diabetes were excluded. Healthy age- and sex-matched individuals were taken as controls. Results: The male to female ratio was 1 : 1.21. Type 2 DM was seen in 89.7% and type 1 DM in 10.3% of the patients. Dermatoses were seen in 88.3% of the diabetics compared to 36% in non-diabetic controls (P<0.05. Cutaneous infections were the most common dermatoses followed by acanthosis nigricans and xerosis in diabetics. Type 2 DM was found to have an increased risk of complications than type 1 DM. Complications of diabetes were seen in 43.7% of the diabetic cases. Diabetic dermopathy, loss of hair over the legs, diabetic foot ulcer, and so on, were found to be the cutaneous markers of DM in our group of cases. Conclusion: Dermatoses were more common in diabetics than non-diabetics. Cutaneous infections formed the largest group of dermatoses in DM.

  4. Establishment of sexual dimorphism in north indian population by odontometric study of permanent maxillary canine teeth

    Directory of Open Access Journals (Sweden)

    Shalini Gupta

    2014-01-01

    Full Text Available Aim: To investigate whether sexual dimorphism can be established by odontometric study of permanent maxillary canine teeth as well as inter-canine width in north Indian population. Study Design: The study was carried out at department of oral and maxillofacial pathology, King George′s Medical University, Lucknow, India on students and patients reporting at OPD. Out of total 180 subjects examined 90 subjects were female and 90 were male. Impressions of the upper arch were made using alginate and casts poured in dental stone. The mesiodistal diameter (MD of the crown of permanent maxillary canine both on right and left sides and inter-canine width were measured. From these measurements, maxillary canine index was calculated. The percentage of sexual dimorphism (SD was assessed for all the parameters. Results: In the present study, the MD of maxillary canine for both right (P = 0.001 and left side (P = 0.005 was significantly higher among male subjects than females, Similar observation was found for inter-canine width too (P = 0.0001. However, the maxillary canine index for right and left was almost similar (P > 0.05 for both male and female subjects. The SD in right and left MDs of maxillary canine was 4.2% and 3.6% respectively. For, inter-canine width it was maximum (13.7%. However, SD in right and left canine index showed negative values (−2.1% and -0.9% respectively. Conclusion: There was SD in MD and inter-canine width of permanent maxillary canine teeth. SD was more on right permanent maxillary canine teeth than left permanent maxillary canine.

  5. A new experimental setup established for low-energy nuclear astrophysics studies

    International Nuclear Information System (INIS)

    Chen, S.Z.; Xu, S.W.; He, J.J.; Hu, J.; Rolfs, C.E.; Zhang, N.T.; Ma, S.B.; Zhang, L.Y.; Hou, S.Q.; Yu, X.Q.; Ma, X.W.

    2014-01-01

    An experimental setup for low-energy nuclear astrophysics studies has been recently established at the Institute of Modern Physics (IMP), Lanzhou, China. The driver machine is a 320 kV high voltage platform, which can provide intense currents of proton, alpha and many heavy ion beams. The energy of a proton beam was calibrated against the nominal platform high voltage by using a well-known resonant reaction of 11 B(p,γ) 12 C and a non-resonant reaction 12 C(p,γ) 13 N. The accuracy was achieved to be better than ±0.5 keV. The detection system consists of a Clover-type high-purity germanium detector, a silicon detector and a plastic scintillator. The performance of the detectors was tested by several experiments. The astrophysical S-factors of the 7 Li(p,γ) 8 Be and 7 Li(p,α) 3 He reactions were measured with this new setup, and our data agree with the values found in the literature. In addition, the upgrade of our driver machine and experimental setup has been discussed. As a future goal, a fascinating National Deep Underground Laboratory in China, the deepest underground laboratory all over the world, is prospected

  6. Establishing an agenda for social studies research in marine renewable energy

    International Nuclear Information System (INIS)

    Kerr, Sandy; Watts, Laura; Colton, John; Conway, Flaxen; Hull, Angela; Johnson, Kate; Jude, Simon; Kannen, Andreas; MacDougall, Shelley; McLachlan, Carly; Potts, Tavis; Vergunst, Jo

    2014-01-01

    To date, academic research relating to Marine Renewable Energy (MRE) has largely focused on resource assessment, technical viability and environmental impact. Experiences from onshore renewable energy tell us that social acceptability is equally critical to project success. However, the specific nature of the marine environment, patterns of resource distribution and governance means experiences from onshore may not be directly applicable to MRE and the marine environment. This paper sets out an agenda for social studies research linked to MRE, identifying key topics for future research: (i) economic impacts; (ii) wealth distribution and community benefits; (iii) communication and knowledge flow; (iv) consultation processes; (v) dealing with uncertainty; (vi) public attitudes; and (vii) planning processes. This agenda is based on the findings of the first workshop of ISSMER, an international research network of social scientists with interests in marine renewable energy. Importantly, this research agenda has been informed by the experiences of developers, regulators and community groups in Orkney. The Orkney archipelago, off the north coast of Scotland, is home to the most intense cluster of MRE research, development and deployment activity in the world today. - Highlights: • Existing marine renewable energy (MRE) research fails to address many social issues. • Social acceptability is essential to the future viability of the MRE industry. • An agenda is established for social science research into MRE

  7. Parametric studies to establish natural circulation in advanced heavy water reactor

    Energy Technology Data Exchange (ETDEWEB)

    Bhatia, S K; Dhawan, M L [Reactor Engineering Division, Bhabha Atomic Research Centre, Mumbai (India)

    1994-06-01

    Design of Advanced Heavy Water Reactor (AHWR) is in progress. It consists of vertical pressure tubes with boiling light water coolant flowing through the tubes and heavy water moderator in the calandria. In PHWRs, core heat removal is through forced circulation of the coolant by PHT pumps. In AHWR, no PHT pumps are used and core heat is carried away by natural circulation of the coolant due to density difference between steam/water mixture inside the core and the water region outside the core. This passive means of core heat removal results in a number of benefits viz. (a) extra length of piping, valves, instruments, power supply and control systems for functioning of instruments are eliminated, (b) plant layout is simplified, (c) maintenance of valves and instruments is reduced. Natural circulation in AHWR is achieved by keeping the steam drum at a sufficient height above the core to get the required driving force. The loop height depends on many factors i.e. channel power, V{sub c}/V{sub f} ratio (ratio of coolant volume to fuel volume) and core height. The effect of these parameters on the loop height to establish natural circulation have been studied and presented. (author). 1 ref., 1 fig., 1 tab.

  8. Establishment of nuclear data system - Feasibility study for neutron-beam= facility at pohang accelerator laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Nam Kung, Won; Koh, In Soo; Cho, Moo Hyun; Kim, Kui Nyun; Kwang, Hung Sik; Park, Sung Joo [Pohang Accelerator Laboratory, Pohang (Korea, Republic of)

    1996-12-01

    Nuclear data which have been produced by a few developed countries in the= past are essential elements to many disciplines, especially to nuclear engineering. As we promote our nuclear industry further to the level of advanced countries, we also have to establish the Nuclear Data System to produce and evaluate nuclear data independently. We have studied the possibility to build a neutron-beam facility utilizing accelerator facilities, technologies and man powers at pohang Accelerator Laboratory. We found specific parameters for the PAL 100-MeV electron linac based on the existing klystron, modulator, accelerating tubes and other facilities in the PAL; the beam energy is 60-100 MeV, the beam current for the short pulse (10 ns) is 2 A and for the long pulse is 500 mA and the pulse repetition rate is 60 Hz. We propose a neutron-beam facility using PAL 100-MeV electron linac where we can use a Ta-target for the neutron generation and three different time-of-flight beam lines (10 m, 20 m, and 100 m). One may find that the proposed neutron-beam facility is comparable with other operating neutron facilities in the world. We conclude that the proposed neutron-beam facility utilizing the existing accelerator facility in the PAL would be an excellent facility for neutron data production in combination with the ` Hanaro` facility in KAERI. 8 refs., 11 tabs., 12 figs. (author)

  9. A Strategic Study of Assembly Plant Establishment in the Kingdom of Saudi Arabia

    OpenAIRE

    Santamaria, Scott

    2001-01-01

    Preface: Traditionally, assembly plant establishment in foreign countries has been a way for corporations to avoid high import duties and/or gain access to free-trade zones. With World Trade Organization (WTO) membership rising, and consequently import duties falling, the role of the assembly plant is changing. Purpose Statement: This thesis concentrates on companies that contemplate on, or have ambitions of establishing industrial assembly facilities in the country of Saudi Arabia. The main ...

  10. Establishing and sustaining research partnerships in Africa: a case study of the UK-Africa Academic Partnership on Chronic Disease

    NARCIS (Netherlands)

    de-Graft Aikins, Ama; Arhinful, Daniel K.; Pitchforth, Emma; Ogedegbe, Gbenga; Allotey, Pascale; Agyemang, Charles

    2012-01-01

    This paper examines the challenges and opportunities in establishing and sustaining north-south research partnerships in Africa through a case study of the UK-Africa Academic Partnership on Chronic Disease. Established in 2006 with seed funding from the British Academy, the partnership aimed to

  11. Timing of high-quality child care and cognitive, language, and preacademic development.

    Science.gov (United States)

    Li, Weilin; Farkas, George; Duncan, Greg J; Burchinal, Margaret R; Vandell, Deborah Lowe

    2013-08-01

    The effects of high- versus low-quality child care during 2 developmental periods (infant-toddlerhood and preschool) were examined using data from the National Institute of Child Health and Human Development Study of Early Child Care. Propensity score matching was used to account for differences in families who used different combinations of child care quality during the 2 developmental periods. Findings indicated that cognitive, language, and preacademic skills prior to school entry were highest among children who experienced high-quality care in both the infant-toddler and preschool periods, somewhat lower among children who experienced high-quality child care during only 1 of these periods, and lowest among children who experienced low-quality care during both periods. Irrespective of the care received during infancy-toddlerhood, high-quality preschool care was related to better language and preacademic outcomes at the end of the preschool period; high-quality infant-toddler care, irrespective of preschool care, was related to better memory skills at the end of the preschool period. (PsycINFO Database Record (c) 2013 APA, all rights reserved).

  12. Wellbeing Understanding in High Quality Healthcare Informatics and Telepractice.

    Science.gov (United States)

    Fiorini, Rodolfo A; De Giacomo, Piero; L'Abate, Luciano

    2016-01-01

    The proper use of healthcare informatics technology and multidimensional conceptual clarity are fundamental to create and boost outstanding clinical and telepractice results. Avoiding even terminology ambiguities is mandatory for high quality of care service. For instance, well-being or wellbeing is a different way to write the same concept only, or there is a good deal of ambiguity around the meanings of these terms the way they are written. In personal health, healthcare and healthcare informatics, this kind of ambiguity and lack of conceptual clarity has been called out repeatedly over the past 50 years. It is time to get the right, terse scenario. We present a brief review to develop and achieve ultimate wellbeing understanding for practical high quality healthcare informatics and telepractice application. This article presents an innovative point of view on deeper wellbeing understanding towards its increased clinical effective application.

  13. Methods and systems for fabricating high quality superconducting tapes

    Science.gov (United States)

    Majkic, Goran; Selvamanickam, Venkat

    2018-02-13

    An MOCVD system fabricates high quality superconductor tapes with variable thicknesses. The MOCVD system can include a gas flow chamber between two parallel channels in a housing. A substrate tape is heated and then passed through the MOCVD housing such that the gas flow is perpendicular to the tape's surface. Precursors are injected into the gas flow for deposition on the substrate tape. In this way, superconductor tapes can be fabricated with variable thicknesses, uniform precursor deposition, and high critical current densities.

  14. Process to Continuously Melt, Refine and Cast High Quality Steel

    Energy Technology Data Exchange (ETDEWEB)

    None

    2005-09-01

    The purpose of this project is to conduct research and development targeted at designing a revolutionary steelmaking process. This process will deliver high quality steel from scrap to the casting mold in one continuous process and will be safer, more productive, and less capital intensive to build and operate than conventional steelmaking. The new process will produce higher quality steel faster than traditional batch processes while consuming less energy and other resources.

  15. Study on establishment and mechanics application of finite element model of bovine eye.

    Science.gov (United States)

    Cui, Yan-Hui; Huang, Ju-Fang; Cheng, Si-Ying; Wei, Wei; Shang, Lei; Li, Na; Xiong, Kun

    2015-08-13

    Glaucoma mainly induced by increased intraocular pressure (IOP), it was believed that the pressure that wall of eyeball withstands were determined by material properties of the tissue and stereoscopic geometry of the eyeball. In order to study the pressure changes in different parts of interior eyeball wall, it is necessary to develop a novel eye ball FEM with more accurate geometry and material properties. Use this model to study the stress changes in different parts of eyeball, especially the lamina cribrosa (LC) under normal physiological and pathological IOP, and provide a mathematical model for biomechanical studies of selected retinal ganglion cells (RGCs) death. (1) Sclera was cut into 3.8-mm wide, 14.5-mm long strips, and cornea was cut into 9.5-mm-wide and 10-mm-long strips; (2) 858 Mini BionixII biomechanical loading instrument was used to stretch sclera and cornea. The stretching rate for sclera was 0.3 mm/s, 3 mm/s, 30 mm/s, 300 mm/s; and for cornea were 0.3 mm/s and 30 mm/s. The deformation-stress curve was recorded; (3) Naso-temporal and longitudinal distance of LC were measured; (4) Micro-CT was used to accurately scan fresh bovine eyes and obtain the geometrical image and data to establish bovine eye model. 3-D reconstruction was performed using these images and data to work out the geometric shape of bovine eye; (5) IOP levels for eyeball FEM was set and the inner wall of eyeball was used taken as load-bearing part. Simulated eyeball FE modeling was run under the IOP level of 10 mmHg, 30 mmHg, 60 mmHg and 100 mmHg, and the force condition of different parts of eyeball was recorded under different IOP levels. (1) We obtained the material parameters more in line with physiological conditions and established a more realistic eyeball model using reversed engineering of parameters optimization method to calculate the complex nonlinear super-elastic and viscoelastic parameters more accurately; (2) We observed the following phenomenon by

  16. Exome sequencing generates high quality data in non-target regions

    Directory of Open Access Journals (Sweden)

    Guo Yan

    2012-05-01

    Full Text Available Abstract Background Exome sequencing using next-generation sequencing technologies is a cost efficient approach to selectively sequencing coding regions of human genome for detection of disease variants. A significant amount of DNA fragments from the capture process fall outside target regions, and sequence data for positions outside target regions have been mostly ignored after alignment. Result We performed whole exome sequencing on 22 subjects using Agilent SureSelect capture reagent and 6 subjects using Illumina TrueSeq capture reagent. We also downloaded sequencing data for 6 subjects from the 1000 Genomes Project Pilot 3 study. Using these data, we examined the quality of SNPs detected outside target regions by computing consistency rate with genotypes obtained from SNP chips or the Hapmap database, transition-transversion (Ti/Tv ratio, and percentage of SNPs inside dbSNP. For all three platforms, we obtained high-quality SNPs outside target regions, and some far from target regions. In our Agilent SureSelect data, we obtained 84,049 high-quality SNPs outside target regions compared to 65,231 SNPs inside target regions (a 129% increase. For our Illumina TrueSeq data, we obtained 222,171 high-quality SNPs outside target regions compared to 95,818 SNPs inside target regions (a 232% increase. For the data from the 1000 Genomes Project, we obtained 7,139 high-quality SNPs outside target regions compared to 1,548 SNPs inside target regions (a 461% increase. Conclusions These results demonstrate that a significant amount of high quality genotypes outside target regions can be obtained from exome sequencing data. These data should not be ignored in genetic epidemiology studies.

  17. Providing high-quality care in primary care settings: how to make trade-offs.

    Science.gov (United States)

    Beaulieu, Marie-Dominique; Geneau, Robert; Del Grande, Claudio; Denis, Jean-Louis; Hudon, Eveline; Haggerty, Jeannie L; Bonin, Lucie; Duplain, Réjean; Goudreau, Johanne; Hogg, William

    2014-05-01

    To gain a deeper understanding of how primary care (PC) practices belonging to different models manage resources to provide high-quality care. Multiple-case study embedded in a cross-sectional study of a random sample of 37 practices. Three regions of Quebec. Health care professionals and staff of 5 PC practices. Five cases showing above-average results on quality-of-care indicators were purposefully selected to contrast on region, practice size, and PC model. Data were collected using an organizational questionnaire; the Team Climate Inventory, which was completed by health care professionals and staff; and 33 individual interviews. Detailed case histories were written and thematic analysis was performed. The core common feature of these practices was their ongoing effort to make trade-offs to deliver services that met their vision of high-quality care. These compromises involved the same 3 areas, but to varying degrees depending on clinic characteristics: developing a shared vision of high-quality care; aligning resource use with that vision; and balancing professional aspirations and population needs. The leadership of the physician lead was crucial. The external environment was perceived as a source of pressure and dilemmas rather than as a source of support in these matters. Irrespective of their models, PC practices' pursuit of high-quality care is based on a vision in which accessibility is a key component, balanced by appropriate management of available resources and of external environment expectations. Current PC reforms often create tensions rather than support PC practices in their pursuit of high-quality care. Copyright© the College of Family Physicians of Canada.

  18. Isolation of high-quality total RNA from leaves of Myrciaria dubia "CAMU CAMU".

    Science.gov (United States)

    Gómez, Juan Carlos Castro; Reátegui, Alina Del Carmen Egoavil; Flores, Julián Torres; Saavedra, Roberson Ramírez; Ruiz, Marianela Cobos; Correa, Sixto Alfredo Imán

    2013-01-01

    Myrciaria dubia is a main source of vitamin C for people in the Amazon region. Molecular studies of M. dubia require high-quality total RNA from different tissues. So far, no protocols have been reported for total RNA isolation from leaves of this species. The objective of this research was to develop protocols for extracting high-quality total RNA from leaves of M. dubia. Total RNA was purified following two modified protocols developed for leaves of other species (by Zeng and Yang, and by Reid et al.) and one modified protocol developed for fruits of the studied species (by Silva). Quantity and quality of purified total RNA were assessed by spectrophotometric and electrophoretic analysis. Additionally, quality of total RNA was evaluated with reverse-transcription polymerase chain reaction (RT-PCR). With these three modified protocols we were able to isolate high-quality RNA (A260nm/A280nm >1.9 and A260nm/A230nm >2.0). Highest yield was produced with the Zeng and Yang modified protocol (384±46µg ARN/g fresh weight). Furthermore, electrophoretic analysis showed the integrity of isolated RNA and the absence of DNA. Another proof of the high quality of our purified RNA was the successful cDNA synthesis and amplification of a segment of the M. dubia actin 1 gene. We report three modified protocols for isolation total RNA from leaves of M. dubia. The modified protocols are easy, rapid, low in cost, and effective for high-quality and quantity total RNA isolation suitable for cDNA synthesis and polymerase chain reaction.

  19. High quality digital holographic reconstruction on analog film

    Science.gov (United States)

    Nelsen, B.; Hartmann, P.

    2017-05-01

    High quality real-time digital holographic reconstruction, i.e. at 30 Hz frame rates, has been at the forefront of research and has been hailed as the holy grail of display systems. While these efforts have produced a fascinating array of computer algorithms and technology, many applications of reconstructing high quality digital holograms do not require such high frame rates. In fact, applications such as 3D holographic lithography even require a stationary mask. Typical devices used for digital hologram reconstruction are based on spatial-light-modulator technology and this technology is great for reconstructing arbitrary holograms on the fly; however, it lacks the high spatial resolution achievable by its analog counterpart, holographic film. Analog holographic film is therefore the method of choice for reconstructing highquality static holograms. The challenge lies in taking a static, high-quality digitally calculated hologram and effectively writing it to holographic film. We have developed a theoretical system based on a tunable phase plate, an intensity adjustable high-coherence laser and a slip-stick based piezo rotation stage to effectively produce a digitally calculated hologram on analog film. The configuration reproduces the individual components, both the amplitude and phase, of the hologram in the Fourier domain. These Fourier components are then individually written on the holographic film after interfering with a reference beam. The system is analogous to writing angularly multiplexed plane waves with individual component phase control.

  20. Long quantum channels for high-quality entanglement transfer

    International Nuclear Information System (INIS)

    Banchi, L; Apollaro, T J G; Cuccoli, A; Verrucchi, P; Vaia, R

    2011-01-01

    High-quality quantum-state and entanglement transfer can be achieved in an unmodulated spin bus operating in the ballistic regime, which occurs when the endpoint qubits A and B are nonperturbatively coupled to the chain by a suitable exchange interaction j 0 . Indeed, the transition amplitude characterizing the transfer quality exhibits a maximum for a finite optimal value j opt 0 (N), where N is the channel length. We show that j opt 0 (N) scales as N -1/6 for large N and that it ensures a high-quality entanglement transfer even in the limit of arbitrarily long channels, almost independently of the channel initialization. For instance, for any chain length the average quantum-state transmission fidelity exceeds 90% and decreases very little in a broad neighbourhood of j opt 0 (N). We emphasize that, taking the reverse point of view, should j 0 be experimentally constrained, high-quality transfer can still be obtained by adjusting the channel length to its optimal value. (paper)

  1. Joining forces: collaborating internationally to deliver high-quality, online postgraduate education in pain management.

    Science.gov (United States)

    Devonshire, Elizabeth; Siddall, Philip

    2011-01-01

    The effective management of pain is a complex and costly global issue, requiring a range of innovative educational strategies to enable culturally appropriate and high-quality health care provision. In response to this issue, the Pain Management Research Institute at the University of Sydney (Sydney, Australia) has established several strategic alliances with other overseas universities to deliver online postgraduate education in pain management. The present article discusses the rationale for joining forces, and the approach adopted in creating and maintaining these alliances. It also provides insights into the benefits, challenges and opportunities associated with collaborative educational initiatives of this nature, from institutional, academic and student perspectives.

  2. Facilitating the openEHR approach - organizational structures for defining high-quality archetypes.

    Science.gov (United States)

    Kohl, Christian Dominik; Garde, Sebastian; Knaup, Petra

    2008-01-01

    Using openEHR archetypes to establish an electronic patient record promises rapid development and system interoperability by using or adopting existing archetypes. However, internationally accepted, high quality archetypes which enable a comprehensive semantic interoperability require adequate development and maintenance processes. Therefore, structures have to be created involving different health professions. In the following we present a model which facilitates and governs distributed but cooperative development and adoption of archetypes by different professionals including peer reviews. Our model consists of a hierarchical structure of professional committees and descriptions of the archetype development process considering these different committees.

  3. ATR-FTIR as a potential tool for controlling high quality vinegar categories

    DEFF Research Database (Denmark)

    Ríos-Reina, Rocío; Callejón, Raquel M.; Oliver-Pozo, Celia

    2017-01-01

    potential as a rapid, cost-effective and non-destructive tool for characterizing different categories of high-quality vinegars. Spectra from 67 wine vinegars belonging to the PDOs “Vinagre de Jerez” and “Vinagre Condado de Huelva”, including their different established categories, were analyzed in the 4000......–600 cm−1 infrared region. Changes associated to categories were observed in the region 1800–900 cm−1. These changes were assigned to certain compounds that increase during aging (e.g. acetic acids, alcohols, esters) or are characteristic of Pedro Ximenez category (e.g. sugars, furfural). Principal...

  4. Bioaccumulation studies with Eisenia fetida using an established degradation test system

    Energy Technology Data Exchange (ETDEWEB)

    Norr, C.; Riepert, F. [Biological Research Centre for Agriculture and Forestry, Inst. for Ecotoxicology and Ecochemistry in Plant Protection, Berlin (Germany)

    2007-12-15

    Background. Earthworms are considered as an appropriate test system to assess the bioaccumulation potential of substances in the terrestrial environment. For regulatory purposes test methods were developed and incorporated in the validation process. A test design that is particularly suited for testing {sup 14}C-labelled substances will be described here. This design was adapted from an established degradation test system for bioaccumulation tests with earthworms in soil. The antibiotic sulfadiazine was used as test substance in this study. Due to the biological activity and the widespread entering into soil by manure application, veterinary medicines have become the target of ecotoxicological risk assessment. A German research group provided the soil samples mixed with liquid pig manure, which contained the {sup 14}C-labelled test substance after having passed through the gut of animals. This exposure pathway reflects the real environmental conditions. Therefore, sulfadiazine was tested even though a significant bioaccumulation potential was not expected to be detected owing to its chemical properties. Methods. Two adult earthworms of the species Eisenia fetida were inserted in a 500 ml glass container filled with 100 g soil. The test substrate consisted of soil mixed with liquid manure containing {sup 14}C-sulfadiazine. The glass containers were fitted with a soda-lime trap, which is permeable for oxygen but absorbs produced CO{sub 2} and other volatile metabolites. As food source for the earthworms, 5 g of mashed potato powder was applied per test container at the beginning of the test. The levels of radioactivity in soil samples and earthworms were determined by combustion in an oxidizer over a four-week exposure phase. The test design follows the instructions described by the OECD draft guideline for testing the bioaccumulation behaviour of chemicals with oligochaetes in soil. (orig.)

  5. The establishment of a multiple sclerosis model for clinical MRI study

    International Nuclear Information System (INIS)

    Zhang Haiqin; Li Kuncheng; Yu Chunshui; Ma Jia; Qin Wen; Ji Zhijuan; Piao Yueshan

    2009-01-01

    Objective: To establish a rat model of multiple sclerosis (MS) for clinical MRI study. Methods: The Lewis (LEW) rats were immunized by myelin oligodendrocyte glycoprotein peptide 35-55 (MOG 35-55 ) emulsified with complete Freunds adjuvant/incomplete Freunds adjuvant. Twenty LEW rats were selected. Group A rats were 5, group B rats were 10 and control group rats were 5. MRI and histopathology analysis were observed on group A and control group, and clinical course were observed on group B. The clinical course was observed and the brain and spinal cord of EAE rats were scanned on 3.0 T MR system with quadrature wrist joint coil on the third day of the acute stage of disease. The T 2 /T 1 weighted images and Gadolinium enhanced T 1 weighted images in 3D volume were obtained respectively. The magnetization transfer ratio (MTR) images were calculated with special software in workstation. Rats were sacrificed within 24 h after MRI, and the histopathological changes of central nervous system were observed. Results: Twice immunization of MOG 35-55 was used and a rat model of MS was successfully induced with all the rats. The model had varied clinical symptoms. The lesions of central nervous system at acute stage on group A (5 rats) were depicted on MRI. The lesions located in the brain and the spinal cord with main manifestation of hyperintensity on T 2 weighed images and hypointensity on T 1 weighted images. Some lesions had Gd-DTPA enhancement, and the value of MTR decreased. The infiltration of mononuclear cells around blood vessels and the extensive distribution of lesions of demyelination in brain and spinal cord were verified by histological examination. Conclusions: Twice immunization of MOG 35-55 could produce a rat model which mimics MS. The model is stable with higher incidence, and the antigen is cheap and obtained easily. The intravital monitoring of brain and spinal cord lesions in MOG 35-55 induced rat model is possible on 3.0 T clinical whole- body MR

  6. A study on the establishment of practical program for the RT promotion plan

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Seong Yen; Jin, J. H.; Beyn, M. W.; Han, H. S.; Park, C.; Lee, J. W.; Yang, M. S.; Jeong, I. H.; Nho, Y. C

    2003-03-01

    The present state of RT utilizations in Korea is categorized into radioisotope applications to treat incurable diseases, food irradiation, and nondestructive test, and radiation applications by radiation generators such as cyclotrons to produce short half-life radioisotopes for medical uses and electron accelerators to make better products of cables and radial tiers. In order to activate more utilizations of RT, the followings should be carried out: 1. Establishment of RT Research Institute and RT Industrial Complex - Establishment of the tentatively named [Radiation Science and Technology Research Center] and 'Cyclotron Center' in four provinces should be effectively carried out as scheduled. - Successful pursuing design and construction of the proton accelerator for research and technology development, and CNS research facility. - Radiation area workers training participating the RT projects; Participation and training of university graduates to the on-going and planned RT projects, Classes for special skills and experts to radiation could be designed at the Consociated Graduate School, being established by joining national research organizations, if necessary. - Secure minimum number of R and D man power for RT development 2. Review design and construction of RI production reactor and construct distribution and transportation of RIs - Constructions of distribution lines and a central depository site with the establishment of Cyclotron Centers and RI production reactor - Designation, as early as possible, of the organization to handle the constructions of the distribution lines and the central depository site. 3. Establishment of an organization to appeal RT industries' concerns - An organization composed of governmental officials, researchers from national research institutes and/or private research institutes, representatives from associations and RT industries should be formed to define the issues to promote radiation uses. 4. Establishment of

  7. A study on the establishment of practical program for the RT promotion plan

    International Nuclear Information System (INIS)

    Kim, Seong Yen; Jin, J. H.; Beyn, M. W.; Han, H. S.; Park, C.; Lee, J. W.; Yang, M. S.; Jeong, I. H.; Nho, Y. C.

    2003-03-01

    The present state of RT utilizations in Korea is categorized into radioisotope applications to treat incurable diseases, food irradiation, and nondestructive test, and radiation applications by radiation generators such as cyclotrons to produce short half-life radioisotopes for medical uses and electron accelerators to make better products of cables and radial tiers. In order to activate more utilizations of RT, the followings should be carried out: 1. Establishment of RT Research Institute and RT Industrial Complex - Establishment of the tentatively named [Radiation Science and Technology Research Center] and 'Cyclotron Center' in four provinces should be effectively carried out as scheduled. - Successful pursuing design and construction of the proton accelerator for research and technology development, and CNS research facility. - Radiation area workers training participating the RT projects; Participation and training of university graduates to the on-going and planned RT projects, Classes for special skills and experts to radiation could be designed at the Consociated Graduate School, being established by joining national research organizations, if necessary. - Secure minimum number of R and D man power for RT development 2. Review design and construction of RI production reactor and construct distribution and transportation of RIs - Constructions of distribution lines and a central depository site with the establishment of Cyclotron Centers and RI production reactor - Designation, as early as possible, of the organization to handle the constructions of the distribution lines and the central depository site. 3. Establishment of an organization to appeal RT industries' concerns - An organization composed of governmental officials, researchers from national research institutes and/or private research institutes, representatives from associations and RT industries should be formed to define the issues to promote radiation uses. 4. Establishment of Pan-ministry PR

  8. Delivering high quality hip fracture rehabilitation: the perspective of occupational and physical therapy practitioners.

    Science.gov (United States)

    Leland, Natalie E; Lepore, Michael; Wong, Carin; Chang, Sun Hwa; Freeman, Lynn; Crum, Karen; Gillies, Heather; Nash, Paul

    2018-03-01

    The majority of post-acute hip fracture rehabilitation in the US is delivered in skilled nursing facilities (SNFs). Currently, there are limited guidelines that equip occupational and physical therapy practitioners with a summary of what constitutes evidence-based high quality rehabilitation. Thus, this study aimed to identify rehabilitation practitioners' perspectives on the practices that constitute high quality hip fracture rehabilitation. Focus groups were conducted with 99 occupational and physical therapy practitioners working in SNFs in southern California. Purposive sampling of facilities was conducted to capture variation in key characteristics known to impact care delivery for this patient population (e.g., financial resources, staffing, and patient case-mix). Questions aimed to elicit practitioners' perspectives on high quality hip fracture rehabilitation practices. Each session was audio-recorded and transcribed. Data were systematically analyzed using a modified grounded theory approach. Seven themes emerged: objectives of care; first 72 h; positioning, pain, and precautions; use of standardized assessments; episode of care practices; facilitating insight into progress; and interdisciplinary collaboration. Clinical guidelines are critical tools to facilitate clinical decision-making and achieve desired patient outcomes. The findings of this study highlight the practitioners' perspective on what constitutes high quality hip fracture rehabilitation. This work provides critical information to advance the development of stakeholder-driven rehabilitation clinical guidelines. Future research is needed to verify the findings from other stakeholders (e.g., patients), ensure the alignment of our findings with current evidence, and develop measures for evaluating their delivery and relationship to desired outcomes. Implications for Rehabilitation This study highlights occupational and physiotherapy therapy practitioners' perspectives on the cumulative best

  9. A study on the establishment of component/equipment performance criteria considering Heavy Water Reactor characteristics

    Energy Technology Data Exchange (ETDEWEB)

    Chang, Keun Sun; Kwon, Young Chul; Lee, Min Kyu; Lee, Yun Soo [Sunmoon Univ., Asan (Korea, Republic of); Chang, Seong Hoong; Ryo, Chang Hyun [Korea Advanced Institute of Science and Technology, Taejon (Korea, Republic of); Kim, Soong Pyung; Hwnag, Jung Rye; Chung, Chul Kee [Chosun Univ., Gwangju (Korea, Republic of)

    2002-03-15

    Foreign and domestic technology trends, regulatory requirements, design and researches for heavy water reactors are analyzed. Safety design guides of Canada industry and regulatory documents and consultative documents of Canada regulatory agency are reviewed. Applicability of MOST guidance 16 Revision 'guidance for technical criteria of nuclear reactor facility' is reviewed. Specific performance criteria are established for components and facilities for heavy water reactor.

  10. Study on specificity of colon carcinoma-associated serum markers and establishment of SVM prediction model

    Directory of Open Access Journals (Sweden)

    Lu Li

    2017-03-01

    Full Text Available We aimed to evaluate the specificity of 12 tumor markers related to colon carcinoma and identify the most sensitive index. Logistic regression and Bhattacharyya distance were used to evaluate the index. Then, different index combinations were used to establish a support vector machine (SVM diagnosis model of malignant colon carcinoma. The accuracy of the model was checked. High accuracy was assumed to indicate the high specificity of the index. Through Logistic regression, three indexes, CEA, HSP60 and CA199, were screened out. Using Bhattacharyya distance, four indexes with the largest Bhattacharyya distance were screened out, including CEA, NSE, AFP, and CA724. The specificity of the combination of the above six indexes was higher than that of other combinations, so did the accuracy of the established SVM identification model. Using Logistic regression and Bhattacharyya distance for detection and establishing an SVM model based on different serum marker combinations can increase diagnostic accuracy, providing a theoretical basis for application of mathematical models in cancer diagnosis.

  11. Key factors for a high-quality VR experience

    Science.gov (United States)

    Champel, Mary-Luc; Doré, Renaud; Mollet, Nicolas

    2017-09-01

    For many years, Virtual Reality has been presented as a promising technology that could deliver a truly new experience to users. The media and entertainment industry is now investigating the possibility to offer a video-based VR 360 experience. Nevertheless, there is a substantial risk that VR 360 could have the same fate as 3DTV if it cannot offer more than just being the next fad. The present paper aims at presenting the various quality factors required for a high-quality VR experience. More specifically, this paper will focus on the main three VR quality pillars: visual, audio and immersion.

  12. Anti-Stokes Luminescence in High Quality Quantum Wells

    Science.gov (United States)

    Vinattieri, A.; Bogani, F.; Miotto, A.; Ceccherini, S.

    1997-11-01

    We present a detailed investigation of the anti-Stokes (AS) luminescence which originates from exciton recombination when below gap excitation is used, in a set of high quality quantum well structures. We observe strong excitonic resonances in the AS signal as measured from photoluminescence and photoluminescence excitation spectra. We demonstrate that neither the electromagnetic coupling between the wells nor the morphological disorder can explain this up-conversion effect. Time-resolved luminescence data after ps excitation and fs correlation spectroscopy results provide clear evidence of the occurrence of a two-step absorption which is assisted by the exciton population resonantly excited by the first photon.

  13. Methods and systems for fabricating high quality superconducting tapes

    Energy Technology Data Exchange (ETDEWEB)

    Majkic, Goran; Selvamanickam, Venkat

    2018-02-13

    An MOCVD system fabricates high quality superconductor tapes with variable thicknesses. The MOCVD system can include a gas flow chamber between two parallel channels in a housing. A substrate tape is heated and then passed through the MOCVD housing such that the gas flow is perpendicular to the tape's surface. Precursors are injected into the gas flow for deposition on the substrate tape. In this way, superconductor tapes can be fabricated with variable thicknesses, uniform precursor deposition, and high critical current densities.

  14. Radon remediation of dwellings with suspended timber floors -case studies from the Building Research Establishment (UK)

    International Nuclear Information System (INIS)

    Welsh, P.; Stephen, R.

    1994-01-01

    Dwellings with suspended floors and high radon levels are proving difficult to remediate. This paper reports on the experience of the Building Research Establishment in dealing with such dwellings. Brief details of the remediation of 14 houses are given, and comparisons are made between the effectiveness of the different techniques adopted. Natural ventilation, mechanical supply ventilation and mechanical extract ventilation are three techniques that have been used successfully as radon remedial measures. Preliminary results suggest that supply ventilation is more effective than extract ventilation. (author)

  15. Studies on the establishment of maximum permissible exposure dose for reference Korean

    International Nuclear Information System (INIS)

    Kim, Y.J.; Lee, K.S.; Chun, K.C.; Kim, C.B.; Chung, K.H.; Kim, S.L.; Kim, M.J.

    1981-01-01

    In order to establish the Reference Korean and maximum permissible exposure dose of Reference Korean, for the first year a total of 9,758 males and 7,019 females were surveyed for the height, weight, a body surface area, and a total of 879 individuals of 180 households located in different 30 localities were analyzed for food consumption and a total of radioactive substances (β-ray) contained in food per capita per day. In this report the external and internal exposure dose were also estimated on the basis of data mostly published in other country as well as in Korea in part

  16. Fabrication of high quality GaN nanopillar arrays by dry and wet chemical etching

    OpenAIRE

    Paramanik, Dipak; Motayed, Abhishek; King, Matthew; Ha, Jong-Yoon; Kryluk, Sergi; Davydov, Albert V.; Talin, Alec

    2013-01-01

    We study strain relaxation and surface damage of GaN nanopillar arrays fabricated using inductively coupled plasma (ICP) etching and post etch wet chemical treatment. We controlled the shape and surface damage of such nanopillar structures through selection of etching parameters. We compared different substrate temperatures and different chlorine-based etch chemistries to fabricate high quality GaN nanopillars. Room temperature photoluminescence and Raman scattering measurements were carried ...

  17. Percutaneous vertebroplasty with a high-quality rotational angiographic unit

    Energy Technology Data Exchange (ETDEWEB)

    Pedicelli, Alessandro [Department of Bioimaging and Radiological Sciences, Catholic University of Sacred Heart, Policl. A.Gemelli, l.go Gemelli 1, 00168 Rome (Italy)], E-mail: apedicelli@rm.unicatt.it; Rollo, Massimo [Department of Bioimaging and Radiological Sciences, Catholic University of Sacred Heart, Policl. A.Gemelli, l.go Gemelli 1, 00168 Rome (Italy)], E-mail: mrollo@rm.unicatt.it; Piano, Mariangela [Department of Bioimaging and Radiological Sciences, Catholic University of Sacred Heart, Policl. A.Gemelli, l.go Gemelli 1, 00168 Rome (Italy)], E-mail: mariangela.piano@gmail.com; Re, Thomas J. [Department of Bioimaging and Radiological Sciences, Catholic University of Sacred Heart, Policl. A.Gemelli, l.go Gemelli 1, 00168 Rome (Italy)], E-mail: tomjre@gmail.com; Cipriani, Maria C. [Department of Gerontology, Catholic University of Sacred Heart, Policl. A.Gemelli, l.go Gemelli 1, 00168 Rome (Italy)], E-mail: alexped@yahoo.com; Colosimo, Cesare [Department of Bioimaging and Radiological Sciences, Catholic University of Sacred Heart, Policl. A.Gemelli, l.go Gemelli 1, 00168 Rome (Italy)], E-mail: colosimo@rm.unicatt.it; Bonomo, Lorenzo [Department of Bioimaging and Radiological Sciences, Catholic University of Sacred Heart, Policl. A.Gemelli, l.go Gemelli 1, 00168 Rome (Italy)], E-mail: lbonomo@rm.unicatt.it

    2009-02-15

    We evaluated the reliability of a rotational angiographic unit (RA) with flat-panel detector as a single technique to guide percutaneous vertebroplasty (PVP) and for post-procedure assessment by 2D and 3D reformatted images. Fifty-five consecutive patients (104 vertebral bodies) were treated under RA fluoroscopy. Rotational acquisitions with 2D and 3D reconstruction were obtained in all patients for immediate post-procedure assessment. In complex cases, this technique was also used to evaluate the needle position during the procedure. All patients underwent CT scan after the procedure. RA and CT findings were compared. In all cases, a safe trans-pedicular access and an accurate control of the bone-cement injection were successfully performed with high-quality fluoroscopy, even at the thoracic levels and in case of vertebra plana. 2D and 3D rotational reconstructions permitted CT-like images that clearly showed needle position and were similar to CT findings in depicting intrasomatic implant-distribution. RA detected 40 cement leakages compared to 42 demonstrated by CT and showed overall 95% sensitivity and 100% specificity compared to CT for final post-procedure assessment. Our preliminary results suggest that high-quality RA is reliable and safe as a single technique for PVP guidance, control and post-procedure assessment. It permits fast and cost-effective procedures avoiding multi-modality imaging.

  18. High quality electron beams from a laser wakefield accelerator

    Energy Technology Data Exchange (ETDEWEB)

    Wiggins, S M; Issac, R C; Welsh, G H; Brunetti, E; Shanks, R P; Anania, M P; Cipiccia, S; Manahan, G G; Aniculaesei, C; Ersfeld, B; Islam, M R; Burgess, R T L; Vieux, G; Jaroszynski, D A [SUPA, Department of Physics, University of Strathclyde, Glasgow (United Kingdom); Gillespie, W A [SUPA, Division of Electronic Engineering and Physics, University of Dundee, Dundee (United Kingdom); MacLeod, A M [School of Computing and Creative Technologies, University of Abertay Dundee, Dundee (United Kingdom); Van der Geer, S B; De Loos, M J, E-mail: m.wiggins@phys.strath.ac.u [Pulsar Physics, Burghstraat 47, 5614 BC Eindhoven (Netherlands)

    2010-12-15

    High quality electron beams have been produced in a laser-plasma accelerator driven by femtosecond laser pulses with a peak power of 26 TW. Electrons are produced with an energy up to 150 MeV from the 2 mm gas jet accelerator and the measured rms relative energy spread is less than 1%. Shot-to-shot stability in the central energy is 3%. Pepper-pot measurements have shown that the normalized transverse emittance is {approx}1{pi} mm mrad while the beam charge is in the range 2-10 pC. The generation of high quality electron beams is understood from simulations accounting for beam loading of the wakefield accelerating structure. Experiments and self-consistent simulations indicate that the beam peak current is several kiloamperes. Efficient transportation of the beam through an undulator is simulated and progress is being made towards the realization of a compact, high peak brilliance free-electron laser operating in the vacuum ultraviolet and soft x-ray wavelength ranges.

  19. Study on the establishment of the IAEA Asian Network for Education in Nuclear Technology

    Energy Technology Data Exchange (ETDEWEB)

    Lee, E. J.; Han, K. W.; Lee, H. Y. [and others

    2005-05-01

    The purpose of this project is to establish a web-portal including a database for the exchange of information and materials for nuclear education and training among ANENT members, and eventually contribute to the sustainable development of nuclear technology for peaceful uses in the Asian IAEA member countries. The project has resulted in the development of a web-portal for ANENT (www.anent-iaea.org). The portal primarily includes a Database for Nuclear Education and Training (NET DB). and functions to deal with group activities which were identified in the first ANENT Coordination Committee meeting. NET DB contains information about relevant education and training institutions/universities in terms of their faculty members or researchers, curricula, education and training materials, etc. While, the group activities are exchange of information and materials for education and training, e-learning, establishment of a reference curricula and a system for a mutual recognition of credits, and cooperation with other networks. Finally, an IAEA regional workshop was held to review the developed web-portal and an agreement was reached on the use of the web-portal with some revisions. Furthermore, the IAEA has requested the NTC/KAERI to develop ANENT Cyber-Platform for the continued upgrading of ANENT Web-portal.

  20. Study on the establishment of the IAEA Asian Network for Education in Nuclear Technology

    International Nuclear Information System (INIS)

    Lee, E. J.; Han, K. W.; Lee, H. Y.

    2005-05-01

    The purpose of this project is to establish a web-portal including a database for the exchange of information and materials for nuclear education and training among ANENT members, and eventually contribute to the sustainable development of nuclear technology for peaceful uses in the Asian IAEA member countries. The project has resulted in the development of a web-portal for ANENT (www.anent-iaea.org). The portal primarily includes a Database for Nuclear Education and Training (NET DB). and functions to deal with group activities which were identified in the first ANENT Coordination Committee meeting. NET DB contains information about relevant education and training institutions/universities in terms of their faculty members or researchers, curricula, education and training materials, etc. While, the group activities are exchange of information and materials for education and training, e-learning, establishment of a reference curricula and a system for a mutual recognition of credits, and cooperation with other networks. Finally, an IAEA regional workshop was held to review the developed web-portal and an agreement was reached on the use of the web-portal with some revisions. Furthermore, the IAEA has requested the NTC/KAERI to develop ANENT Cyber-Platform for the continued upgrading of ANENT Web-portal

  1. Experimental study on the hydroxyproline content of enteroanastomoses established in irradiated intestines of rats

    International Nuclear Information System (INIS)

    Winter, S.

    1984-01-01

    Cross-bred Sprague-Dawley rats were subjected to percutaneous X-irradiation of the rectosigmoid using a split-dose regimen and focal dose of 50 Gy. One day as well as one, two and four months after the cessation of irradiation a termino-terminal anastomosis was established in the area exposed to radiation. On days, 3, 7, 14 and 21 after surgery those parts of the intestine, which had been united by anastomosis, were removed in order to determine the hydroxyproline content of the latter. Further determinations were made in specimens of the tissue 1 cm above the anastomosis and carried out before surgery, after intraperitoneal injection of the anaesthetic alone or in animals subjected to laparatomy including intestinal exposure, where no anastomosis was established. In general, the collagen levels determined in colon anastomoses of irradiated or non-irradiated intestines of rats did not point to any adverse effects from radiation on the healing process. This result appears to be largely consistent with the experiences so far gained at the clinical level in the preoperative irradiation of colon carcinomas. (orig./MG) [de

  2. A Study on Establishment of Buffer Zone of Radioactive Waste Repository

    International Nuclear Information System (INIS)

    Yoon, Jeong Hyoun; Park, Joo Wan; Ju, Min Su; Kim, Chang Lak; Park, Jin Baek

    2008-01-01

    A new proposed repository has a final capacity of 800,000 drums radioactive waste. Most of foreign repositories have a general practice of segregating control zones which mainly contributes to classification of degree of control, whether it is called buffer zone or not. Domestic regulatory requirements of establishment of buffer zone in a repository are not much different from those of nuclear power plants for operation period, in which satisfactory design objective or performance objective is the most important factor in determination of the buffer zone. The meaning of buffer zone after closure is a minimum requested area which can prevent inadvertent intruders from leading to non-allowable exposure during institutional control period. Safety assessment with drinking well scenario giving rise to the highest probability of exposure among the intruder's actions can verify fulfillment of the buffer zone which is determined by operational safety of the repository. At present. for the repository to be constructed in a few years, the same procedure and concept as described in this paper are applied that can satisfy regulatory requirements and radiological safety as well. However, the capacity of the repository will be stepwise extended upto 800,000 drums, consequently its layout will be varied too. Timely considerations will be necessary for current boundary of the buffer zone which has been established on the basis of 100,000 drums disposal.

  3. (-201) β-Gallium oxide substrate for high quality GaN materials

    KAUST Repository

    Roqan, Iman S.

    2015-03-13

    (-201) oriented β-Ga2O3 has the potential to be used as a transparent and conductive substrate for GaN-growth. The key advantages of Ga2O3 are its small lattice mismatches (4.7%), appropriate structural, thermal and electrical properties and a competitive price compared to other substrates. Optical characterization show that GaN layers grown on (-201) oriented β-Ga2O3 are dominated by intense bandedge emission with a high luminescence efficiency. Atomic force microscopy studies show a modest threading dislocation density of ~108 cm-2, while complementary Raman spectroscopy indicates that the GaN epilayer is of high quality with slight compressive strain. Room temperature time-findings suggest that the limitation of the photoluminescence lifetime (~500 ps) is due to nonradiative recombination arising from threading dislocation. Therefore, by optimizing the growth conditions, high quality material with significant optical efficiency can be obtained.

  4. High quality atomically thin PtSe2 films grown by molecular beam epitaxy

    Science.gov (United States)

    Yan, Mingzhe; Wang, Eryin; Zhou, Xue; Zhang, Guangqi; Zhang, Hongyun; Zhang, Kenan; Yao, Wei; Lu, Nianpeng; Yang, Shuzhen; Wu, Shilong; Yoshikawa, Tomoki; Miyamoto, Koji; Okuda, Taichi; Wu, Yang; Yu, Pu; Duan, Wenhui; Zhou, Shuyun

    2017-12-01

    Atomically thin PtSe2 films have attracted extensive research interests for potential applications in high-speed electronics, spintronics and photodetectors. Obtaining high quality thin films with large size and controlled thickness is critical. Here we report the first successful epitaxial growth of high quality PtSe2 films by molecular beam epitaxy. Atomically thin films from 1 ML to 22 ML have been grown and characterized by low-energy electron diffraction, Raman spectroscopy and x-ray photoemission spectroscopy. Moreover, a systematic thickness dependent study of the electronic structure is revealed by angle-resolved photoemission spectroscopy (ARPES), and helical spin texture is revealed by spin-ARPES. Our work provides new opportunities for growing large size single crystalline films to investigate the physical properties and potential applications of PtSe2.

  5. Selection of process parameters for producing high quality defatted sesame flour at pilot scale.

    Science.gov (United States)

    Manikantan, M R; Sharma, Rajiv; Yadav, D N; Gupta, R K

    2015-03-01

    The present work was undertaken to study the effect of pearling duration, soaking time, steaming duration and drying temperature on the quality of sesame seeds and mechanically extracted partially defatted sesame cake. On the basis of quality attributes i.e. high protein, low crude fibre, low residual oil and low oxalic acid, the optimum process parameters were selected. The combination of 20 min of pearling duration, 15 min of soaking, 15 min of steaming at 100 kPa pressure and drying at 50 °C yielded high quality partially defatted protein rich sesame flour as compared to untreated defatted sesame flour. The developed high quality partially defatted protein rich sesame flour may be used in various food applications as a vital ingredient to increase the nutritional significance of the prepared foodstuffs.

  6. The technological study on the decommissioning of nuclear facility, etc. in the Tokai Research Establishment

    International Nuclear Information System (INIS)

    Tomii, Hiroyuki; Matsuo, Kiyoshi; Shiraishi, Kunio; Kato, Rokuro; Watabe, Kozou; Higashiyama, Yutaka; Nagane, Satoru

    2005-03-01

    Since JPDR is dismantled and is removed, in Tokai Research Establishment, Japan Atomic Energy Research Institute, the dismantling of nuclear facility which finished the mission, etc. is advanced. At present, nuclear facility as a dismantling object count the approximately 20 facilities, and decommissioning plan of these facilities becomes an important problem, when the decommissioning countermeasure is considered. However, decommissioning techniques in proportion to various nuclear facility, etc. are clearly, and it has not been determined. In this report, the technical consideration on decommissioning techniques of nuclear facility promoted on the basis of this experience in future, while until now decommissioning experience and technical knowledge are arranged, etc. was added in order to appropriately and surely carry out decommissioning techniques and legal procedures, etc. (author)

  7. A Study on Establishing National Technology Strategy of Fusion Energy Development: Combining PEST-SWOT Methodologies

    Energy Technology Data Exchange (ETDEWEB)

    Chang, Han Soo; Choi, Won Jae; Tho, Hyun Soo; Kang, Dong Yup; Kim, In Chung [National Fusion Research Institute, Daejeon (Korea, Republic of)

    2012-05-15

    Nuclear fusion, the joining of light nuclei of hydrogen into heavier nuclei of helium, has potential environmental, safety and proliferation characteristics as an energy source. It can also, provide an adequate amount of fuel to power civilization for a long time compared to human history. It is, however, more challenging to convert to an energy source than nuclear fission. To overcome this, Korea enacted a law to promote the development of fusion as an energy source in 2007. In accordance with this law, the government will establish a promotion plan to develop fusion energy, including policy goals, a framework, strategies, infrastructure, funding, human resources, international cooperation and etc. This will be reviewed every five years. This paper is focused on the combining PEST (political, economic, social and technological) method with SWOT (strength, weakness, opportunity and threat) analysis, which is a prerequisite to form national fusion energy technology strategy

  8. A Study on Establishing National Technology Strategy of Fusion Energy Development: Combining PEST-SWOT Methodologies

    International Nuclear Information System (INIS)

    Chang, Han Soo; Choi, Won Jae; Tho, Hyun Soo; Kang, Dong Yup; Kim, In Chung

    2012-01-01

    Nuclear fusion, the joining of light nuclei of hydrogen into heavier nuclei of helium, has potential environmental, safety and proliferation characteristics as an energy source. It can also, provide an adequate amount of fuel to power civilization for a long time compared to human history. It is, however, more challenging to convert to an energy source than nuclear fission. To overcome this, Korea enacted a law to promote the development of fusion as an energy source in 2007. In accordance with this law, the government will establish a promotion plan to develop fusion energy, including policy goals, a framework, strategies, infrastructure, funding, human resources, international cooperation and etc. This will be reviewed every five years. This paper is focused on the combining PEST (political, economic, social and technological) method with SWOT (strength, weakness, opportunity and threat) analysis, which is a prerequisite to form national fusion energy technology strategy

  9. Changes in gait characteristics of women with early and established medial knee osteoarthritis : Results from a 2-years longitudinal study

    NARCIS (Netherlands)

    Mahmoudian, Armaghan; van Dieёn, Jaap H.; Baert, Isabel A.C.; Bruijn, Sjoerd M.; Faber, Gert S.; Luyten, Frank P.; Verschueren, Sabine M.P.

    2017-01-01

    Background Despite the large number of cross-sectional studies on gait in subjects with knee osteoarthritis, there are scarcely any longitudinal studies on gait changes in knee osteoarthritis. Methods Gait analysis was performed on 25 women with early and 18 with established medial knee

  10. Characteristics of primary care practices associated with high quality of care.

    Science.gov (United States)

    Beaulieu, Marie-Dominique; Haggerty, Jeannie; Tousignant, Pierre; Barnsley, Janet; Hogg, William; Geneau, Robert; Hudon, Éveline; Duplain, Réjean; Denis, Jean-Louis; Bonin, Lucie; Del Grande, Claudio; Dragieva, Natalyia

    2013-09-03

    No primary practice care model has been shown to be superior in achieving high-quality primary care. We aimed to identify the organizational characteristics of primary care practices that provide high-quality primary care. We performed a cross-sectional observational study involving a stratified random sample of 37 primary care practices from 3 regions of Quebec. We recruited 1457 patients who had 1 of 2 chronic care conditions or 1 of 6 episodic care conditions. The main outcome was the overall technical quality score. We measured organizational characteristics by use of a validated questionnaire and the Team Climate Inventory. Statistical analyses were based on multilevel regression modelling. The following characteristics were strongly associated with overall technical quality of care score: physician remuneration method (27.0; 95% confidence interval [CI] 19.0-35.0), extent of sharing of administrative resources (7.6; 95% CI 0.8-14.4), presence of allied health professionals (15.3; 95% CI 5.4-25.2) and/or specialist physicians (19.6; 95% CI 8.3-30.9), the presence of mechanisms for maintaining or evaluating competence (7.7; 95% CI 3.0-12.4) and average organizational access to the practice (4.9; 95% CI 2.6-7.2). The number of physicians (1.2; 95% CI 0.6-1.8) and the average Team Climate Inventory score (1.3; 95% CI 0.1-2.5) were modestly associated with high-quality care. We identified a common set of organizational characteristics associated with high-quality primary care. Many of these characteristics are amenable to change through practice-level organizational changes.

  11. High quality diesel fuels by VO-LSGO hydrotreatment

    Energy Technology Data Exchange (ETDEWEB)

    Stanica-Ezeanu, Dorin; Juganaru, Traian [Petroleum and Gas Univ. of Ploiesti (Romania)

    2013-06-01

    The aim of the paper is to obtain a high quality Diesel fuel by hydro-deoxigenation of vegetable oils (VO) mixed with a low sulfur gasoil (LSGO). The process is possible by using a bi-functional catalyst Ni-Mo supported by an activated Al{sub 2}O{sub 3} containing 2% Ultrastable Y-zeolite. The experimental conditions were: T =340 - 380 C, Pressure = 50 bar, LHSV = 1,5 h{sup -1}, H{sub 2}/Feed ratio = 15 mole H{sub 2} /mole liquid feed. The liquid product was separated in two fractions: a light distillate (similar to gasoline) and a heavy distillate (boiling point > 200 C) with very good characteristics for Diesel engines. The reaction chemistry is very complex, but the de-oxygenation process is decisive for the chemical structure of hydrocarbons from final product. Finally, a schema for the reaction mechanism is proposed. (orig.)

  12. Supercapacitors based on high-quality graphene scrolls

    Science.gov (United States)

    Zeng, Fanyan; Kuang, Yafei; Liu, Gaoqin; Liu, Rui; Huang, Zhongyuan; Fu, Chaopeng; Zhou, Haihui

    2012-06-01

    High-quality graphene scrolls (GSS) with a unique scrolled topography are designed using a microexplosion method. Their capacitance properties are investigated by cyclic voltammetry, galvanostatic charge-discharge and electrical impedance spectroscopy. Compared with the specific capacity of 110 F g-1 for graphene sheets, a remarkable capacity of 162.2 F g-1 is obtained at the current density of 1.0 A g-1 in 6 M KOH aqueous solution owing to the unique scrolled structure of GSS. The capacity value is increased by about 50% only because of the topological change of graphene sheets. Meanwhile, GSS exhibit excellent long-term cycling stability along with 96.8% retained after 1000 cycles at 1.0 A g-1. These encouraging results indicate that GSS based on the topological structure of graphene sheets are a kind of promising material for supercapacitors.

  13. High quality flux control system for electron gun evaporation

    International Nuclear Information System (INIS)

    Appelbloom, A.M.; Hadley, P.; van der Marel, D.; Mooij, J.E.

    1991-01-01

    This paper reports on a high quality flux control system for electron gun evaporation developed and tested for the MBE growth of high temperature superconductors. The system can be applied to any electron gun without altering the electron gun itself. Essential elements of the system are a high bandwidth mass spectrometer, control electronics and a high voltage modulator to sweep the electron beam over the melt at high frequencies. the sweep amplitude of the electron beam is used to control the evaporation flux at high frequencies. The feedback loop of the system has a bandwidth of over 100 Hz, which makes it possible to grow superlattices and layered structures in a fast and precisely controlled manner

  14. Quality management manual for production of high quality cassava flour

    DEFF Research Database (Denmark)

    Dziedzoave, Nanam Tay; Abass, Adebayo Busura; Amoa-Awua, Wisdom K.

    The high quality cassava flour (HQCF) industry has just started to evolve in Africa and elsewhere. The sustainability of the growing industry, the profitability of small- and medium-scale enterprises (SMEs) that are active in the industry and good-health of consumers can best be guaranteed through...... the adoption of proper quality and food safety procedures. Cassava processing enterprises involved in the productionof HQCF must therefore be commited to the quality and food safety of the HQCF. They must have the right technology, appropriate processing machhinery, standard testing instruments...... and the necessary technical expertise. This quality manual was therefore developed to guide small- to medium-scale cassava in the design and implematation of Hazard Analysis Critical Control Point (HACCP) system and Good manufacturing Practices (GMP) plans for HQCF production. It describes the HQCF production...

  15. Biotransformation of Organic Waste into High Quality Fertilizer

    DEFF Research Database (Denmark)

    Bryndum, Sofie

    Agriculture faces several challenges of future provision of nutrients such as limited P reserves and increasing prices of synthetic fertilizers and recycling of nutrients from organic waste can be an important strategy for the long-term sustainability of the agricultural systems. Organically...... and S, is often low; and (3) the unbalanced composition of nutrients rarely matches crop demands. Therefore the objective of this project was to investigate the potential for (1) recycling nutrients from agro-industrial wastes and (2) compost biotransformation into high-quality organic fertilizers...... other uses into fertilizer use would be unlikely. An estimated ~50 % of the total organic waste pool, primarily consisting of animal manure and waste from the processing of sugar cane, coffee, oil palm and oranges, is currently being re-used as “fertilizers”, meaning it is eventually returned...

  16. Automated Theorem Proving in High-Quality Software Design

    Science.gov (United States)

    Schumann, Johann; Swanson, Keith (Technical Monitor)

    2001-01-01

    The amount and complexity of software developed during the last few years has increased tremendously. In particular, programs are being used more and more in embedded systems (from car-brakes to plant-control). Many of these applications are safety-relevant, i.e. a malfunction of hardware or software can cause severe damage or loss. Tremendous risks are typically present in the area of aviation, (nuclear) power plants or (chemical) plant control. Here, even small problems can lead to thousands of casualties and huge financial losses. Large financial risks also exist when computer systems are used in the area of telecommunication (telephone, electronic commerce) or space exploration. Computer applications in this area are not only subject to safety considerations, but also security issues are important. All these systems must be designed and developed to guarantee high quality with respect to safety and security. Even in an industrial setting which is (or at least should be) aware of the high requirements in Software Engineering, many incidents occur. For example, the Warshaw Airbus crash, was caused by an incomplete requirements specification. Uncontrolled reuse of an Ariane 4 software module was the reason for the Ariane 5 disaster. Some recent incidents in the telecommunication area, like illegal "cloning" of smart-cards of D2GSM handies, or the extraction of (secret) passwords from German T-online users show that also in this area serious flaws can happen. Due to the inherent complexity of computer systems, most authors claim that only a rigorous application of formal methods in all stages of the software life cycle can ensure high quality of the software and lead to real safe and secure systems. In this paper, we will have a look, in how far automated theorem proving can contribute to a more widespread application of formal methods and their tools, and what automated theorem provers (ATPs) must provide in order to be useful.

  17. Clinicians' and researchers' perspectives on establishing and implementing core outcomes in haemodialysis: semistructured interview study.

    Science.gov (United States)

    Tong, Allison; Crowe, Sally; Gill, John S; Harris, Tess; Hemmelgarn, Brenda R; Manns, Braden; Pecoits-Filho, Roberto; Tugwell, Peter; van Biesen, Wim; Wang, Angela Yee Moon; Wheeler, David C; Winkelmayer, Wolfgang C; Gutman, Talia; Ju, Angela; O'Lone, Emma; Sautenet, Benedicte; Viecelli, Andrea; Craig, Jonathan C

    2018-04-20

    To describe the perspectives of clinicians and researchers on identifying, establishing and implementing core outcomes in haemodialysis and their expected impact. Face-to-face, semistructured interviews; thematic analysis. Twenty-seven centres across nine countries. Fifty-eight nephrologists (42 (72%) who were also triallists). We identified six themes: reflecting direct patient relevance and impact (survival as the primary goal of dialysis, enabling well-being and functioning, severe consequences of comorbidities and complications, indicators of treatment success, universal relevance, stakeholder consensus); amenable and responsive to interventions (realistic and possible to intervene on, differentiating between treatments); reflective of economic burden on healthcare; feasibility of implementation (clarity and consistency in definition, easily measurable, requiring minimal resources, creating a cultural shift, aversion to intensifying bureaucracy, allowing justifiable exceptions); authoritative inducement and directive (endorsement for legitimacy, necessity of buy-in from dialysis providers, incentivising uptake); instituting patient-centredness (explicitly addressing patient-important outcomes, reciprocating trial participation, improving comparability of interventions for decision-making, driving quality improvement and compelling a focus on quality of life). Nephrologists emphasised that core outcomes should be relevant to patients, amenable to change, feasible to implement and supported by stakeholder organisations. They expected core outcomes would improve patient-centred care and outcomes. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  18. A Study on Establishment of Nuclear Power Plant Technical Support System and Activation Plan

    International Nuclear Information System (INIS)

    Wi, M. H.; Park, W. S.; Lee, H. S.; Kim, J. H.; Won, B. C.; Kim, Y. H.; Goo, D. S.; Choi, H. B.

    2009-11-01

    This report includes activities related to establishment of 'BaroBaro nuclear plant technical support center', 'selection of nuclear plant applicable technology', and 'various information interchange between KAERI and nuclear power plant'. 'BaraBaro center was newly organized to support on resolving the technical difficulties in operation of nuclear power plant'. The center consists of 10 technical parts and a leading expert is assigned to each part to support more efficiently. This center is always served for 24 hour. The plant operators can register their problem to the center by a call, e-mail, or internet and they can receive the answer about what they issued from KAERI experts. To make a brochure, we selected 32 technologies which are applicable in nuclear plant without additional R and D activity. The brochure was distributed to the officer in charge of nuclear plant operations. Various meetings were held to increase interchange of experience and technology between KAERI and nuclear power plant and we discussed many different issues at that meeting

  19. Study of the ablation of extra-low temperature aggregate target and the development of technology of formation of non-equilibrium high-quality functional thin films by the plume control; Gokuteion gyoshutai target no abureshon oyobi purumu seigyo ni yoru hiheiko kohinshitsu kinosei usumaku seisei gijutsu kaihatsu ni kansuru kenkyu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-03-01

    A study was made on factors of the formation of high-quality thin films in the pulse laser deposition (PLD) method, a synthesis method of high-grade functional material thin films. In the experiment, plume current measurements using Cu target were conducted for the control of electric and magnetic fields. Especially, the measuring evaluation was made of the two-dimensional distribution including not only the central part of the substrate placed opposite to the target, but the periphery of the substrate. As a result, the following was found out. The distribution of charged particles in the plume is different in positive charge and negative charge, and the negative charge is dispersed/distributed more widely. Accelerating/decelerating effects of charged particles by the electric field are saturated when the bias voltage absolute value is approximately 100V. Ionization is promoted by giving the magnetic field, and the plume distribution is expanded. Positive charged particles of the plume in the magnetic field are decelerated. In the distribution control by giving the electric field, it is effective to think improvement of the distribution not by attracting charged particles by the electric field, but by shutting out charged particles of the same polarity. 29 refs., 75 figs., 2 tabs.

  20. A Study on Strategy Establishment for Foreign Market Penetrating of Nuclear Technology Venture Business

    Energy Technology Data Exchange (ETDEWEB)

    Song, Ki Dong; Kim, S. S.; Choi, Y. D.; Park, C. S.; Bae, C. I.; Chung, J. M.; Roe, S. P

    2007-05-15

    The objective of this study is to suggest feasible strategy for foreign market penetration of nuclear venture technology business. Especially, this study focuses on the technology and product export to the Frankfurt-Hoechst Industrial Park in Germany. This study analyzed the operating system of German Industrial Park, especially the Frankfurt-Hoechst Industrial Park. This study also analyzed the current status of Industrial Science Parks in Northern European countries such as Finland, Sweden, and England. Then, this study suggested the strategy for nuclear technology venture business to penetrate German export market effectively.

  1. A Study on Strategy Establishment for Foreign Market Penetrating of Nuclear Technology Venture Business

    International Nuclear Information System (INIS)

    Song, Ki Dong; Kim, S. S.; Choi, Y. D.; Park, C. S.; Bae, C. I.; Chung, J. M.; Roe, S. P.

    2007-05-01

    The objective of this study is to suggest feasible strategy for foreign market penetration of nuclear venture technology business. Especially, this study focuses on the technology and product export to the Frankfurt-Hoechst Industrial Park in Germany. This study analyzed the operating system of German Industrial Park, especially the Frankfurt-Hoechst Industrial Park. This study also analyzed the current status of Industrial Science Parks in Northern European countries such as Finland, Sweden, and England. Then, this study suggested the strategy for nuclear technology venture business to penetrate German export market effectively

  2. Possible causes of variation in acrylamide concentration in French fries prepared in food service establishments: an observational study

    NARCIS (Netherlands)

    Sanny, M.A.I.; Jinap, S.; Bakker, E.J.; Boekel, van M.A.J.S.; Luning, P.A.

    2012-01-01

    Acrylamide is a probable human carcinogen, and its presence in a range of fried and oven-cooked foods has raised considerable health concern world-wide. Dietary intake studies observed significant variations in acrylamide concentrations, which complicate risk assessment and the establishment of

  3. Alternatives to clearcutting in the old-growth forests of southeast Alaska: study plan and establishment report.

    Science.gov (United States)

    Michael H. McClellan; Douglas N. Swanston; Paul E. Hennon; Robert L. Deal; Toni L. de Santo; Mark S. Wipfli

    2000-01-01

    Much is known about the ecological effects, economics, and social impacts of clearcutting, but little documented experience with other silvicultural systems exists in southeast Alaska. The Pacific Northwest Research Station and the Alaska Region of the USDA Forest Service have cooperatively established an interdisciplinary study of ecosystem and social responses to...

  4. A Study on the Establishment of Pochonka and Chonmun yucho in the Early Choson Dynasty

    Science.gov (United States)

    Ahn, Sang-Hyeon

    2009-12-01

    's Pochonka was formed between 1392 A.D. and 1430 A.D. as a part of establishment of the cultural and political foundation of the Choson dynasty by adopting the advanced system of the Song dynasty.

  5. A Study on the Establishment of Pochonka and Chonmun yucho in the Early Choson Dynasty

    Directory of Open Access Journals (Sweden)

    Sang-Hyeon Ahn

    2009-12-01

    that Choson`s Pochonka was formed between 1392 A.D. and 1430 A.D. as a part of establishment of the cultural and political foundation of the Choson dynasty by adopting the advanced system of the Song dynasty.

  6. Preliminary Study on the Establishment of Regulatory Infrastructure for a Commercial SMART Licensing

    Energy Technology Data Exchange (ETDEWEB)

    Yune, Young Gill; Roh, Kyung Wan; Kang, Dong Gu; Kim, Hho Jung; Jo, Jong Chull [Korea Institute of Nuclear Safety, Daejeon (Korea, Republic of)

    2007-10-15

    The SMART, an integral type of PWR with the capacity of 330MWth, has been developed for multi-purposes such as seawater desalination, ship propulsion, and district heating in Korea since early 1990s. The basic design of the SMART had been completed in 2002. For the demonstration of the safety and performance of the SMART, a project to construct a 1/5 scaled-down prototype reactor with capacity of 65MWth, called as SMART-P(SMART Pilot Plant), has been performed from 2002 to 2006. However, in 2006, the project to construct the SMART-P was replaced with a preliminary project to develop a commercial SMART in order to advance commercialization of the SMART. Since the SMART is the first commercial reactor adopting the integral design concept and new system/components such as passive residual heat removal system, canned motor pump, and helical tube steam generator in Korea, some verification tests need to be performed to demonstrate the safety and performance of the SMART. Also, since several new design computer codes that have not yet been confirmed by the regulatory body are expected to be used in the design, some validation tests should be performed to demonstrate their applicability for important accident phenomena. In order to carry out the SMART development project satisfactorily and to prevent any undesirable delay of licensing process, it is necessary to establish a well-planned verification test program in advance through the early identification of the scope and items of the verification tests. Also, the issues for which either policy decision-makings or detailed technical evaluations are needed should be identified in an early stage of design, and the regulatory positions for the issues should be provided either timely or in advance. Advance identification of regulatory requirements/guides to be amended or newly developed enables to provide regulatory directions for such items in the early stage of design. The objective of this paper is to introduce the current

  7. Preliminary Study on the Establishment of Regulatory Infrastructure for a Commercial SMART Licensing

    International Nuclear Information System (INIS)

    Yune, Young Gill; Roh, Kyung Wan; Kang, Dong Gu; Kim, Hho Jung; Jo, Jong Chull

    2007-01-01

    The SMART, an integral type of PWR with the capacity of 330MWth, has been developed for multi-purposes such as seawater desalination, ship propulsion, and district heating in Korea since early 1990s. The basic design of the SMART had been completed in 2002. For the demonstration of the safety and performance of the SMART, a project to construct a 1/5 scaled-down prototype reactor with capacity of 65MWth, called as SMART-P(SMART Pilot Plant), has been performed from 2002 to 2006. However, in 2006, the project to construct the SMART-P was replaced with a preliminary project to develop a commercial SMART in order to advance commercialization of the SMART. Since the SMART is the first commercial reactor adopting the integral design concept and new system/components such as passive residual heat removal system, canned motor pump, and helical tube steam generator in Korea, some verification tests need to be performed to demonstrate the safety and performance of the SMART. Also, since several new design computer codes that have not yet been confirmed by the regulatory body are expected to be used in the design, some validation tests should be performed to demonstrate their applicability for important accident phenomena. In order to carry out the SMART development project satisfactorily and to prevent any undesirable delay of licensing process, it is necessary to establish a well-planned verification test program in advance through the early identification of the scope and items of the verification tests. Also, the issues for which either policy decision-makings or detailed technical evaluations are needed should be identified in an early stage of design, and the regulatory positions for the issues should be provided either timely or in advance. Advance identification of regulatory requirements/guides to be amended or newly developed enables to provide regulatory directions for such items in the early stage of design. The objective of this paper is to introduce the current

  8. The Study for the Establishment of the Korea Nuclear Liability System complying with International Standards

    International Nuclear Information System (INIS)

    Lee, D. S.; Chung, W. S.; Yun, S. W.; Kim, H. J.; Lee, J. H.

    2011-06-01

    This study is for making system of the fast and adequate compensation to the victim in the nuclear accident of domestic and foreign country. As a method to come true the purpose we reviewed Convention on Supplementary Compensation for Nuclear Damage (hereinafter 'CSC') and designed enabling laws for joining the CSC. Moreover international workshop regarding the CSC was hold as a main assignment of this study for sharing knowledge and information with neighboring countries. Convention relating to Civil Liability in the Field of Maritime Carriage on Nuclear Material, 1971 shall be analyzed in this study. Legal approach to the CSC and designing enabling laws for joining the CSC were enclosed to this study. As a result of the international workshop this study shows how U.S. (CSC member country) deals with CSC and mandatory obligation of donating the public funds. Finally Convention relating to Civil Liability in the Field of Maritime Carriage on Nuclear Material, 1971 is analyzed legally

  9. Comparative study of the legal status of NGOs in Iran and France: from the establishment to work

    Directory of Open Access Journals (Sweden)

    Mohammad Hossein Ramazani Ghavamabadi

    2015-12-01

    Full Text Available THE NGOs one of the most important -state actors. For this to compile useful organizations the state regulations regarding established and codified their activity. This study sought to explain the issue and established barter their activities in two Iranian legal system and France. In Iranian legal system regulations in the founded and barter their activity there is in comparison with France legal system a bit tough. supervision previous in establishment time and supervision next previous after the foundation and all activities are subjects in this study compared to that between the two legal system under study. One of the most prominent works of the identified legal personality for this organization are the case. The new penal trial Iran inspired by the French Penal procedure law a step forward in support of the presence of the barter their punishment in the process. What is important is the codification of legal about cathedral establishment of this organization are derived from the experience of the other legal system legal system including the French so that through this the presence and activities of these organizations in the fields of different facilitation.

  10. Reducing Societal Obesity: Establishing a Separate Exercise Model through Studies of Group Behavior.

    Science.gov (United States)

    Puterbaugh, J S

    2016-01-01

    The past 50 years has brought attention to high and increasing levels of human obesity in most of the industrialized world. The medical profession has noticed, has evaluated, and has developed models for studying, preventing, and reversing obesity. The current model prescribes activity in specific quantities such as days, minutes, heart rates, and footfalls. Although decreased levels of activity have come from changes revolving around built environments and social networks, the existing medical model to lower body weights by increasing activity remains individually prescriptive. It is not working. The study of societal obesity precludes the individual and must involve group behavioral studies. Such studies necessitate acquiring separate tools and, therefore, require a significant change in the evaluation and treatment of obesity. Finding groups with common activities and lower levels of obesity would allow the development of new models of land use and encourage active lifestyles through shared interests.

  11. Establishment of infection models in zebrafish larvae (Danio rerio to study the pathogenesis of Aeromonas hydrophila.

    Directory of Open Access Journals (Sweden)

    Paolo Roberto Saraceni

    2016-08-01

    Full Text Available Aeromonas hydrophila is a Gram-negative opportunistic pathogen of fish and terrestrial animals. In humans, A. hydrophila mainly causes gastroenteritis, septicaemia and tissue infections. The mechanisms of infection, the main virulence factors and the host immune response triggered by A. hydrophila have been studied in detail using murine models and adult fish. However, the great limitation of studying adult animals is that the animal must be sacrificed and its tissues/organs extracted, which prevents the study of the infectious processes in the whole living animal.Zebrafish larvae are being used for the analysis of several infectious diseases, but their use for studying the pathogenesis of A. hydrophila has never been explored. The great advantage of zebrafish larvae is their transparency during the first week after fertilization, which allows detailed descriptions of the infectious processes using in vivo imaging techniques such as differential interferential contrast (DIC and fluorescence microscopy. Moreover, the availability of fluorescent pathogens and transgenic reporter zebrafish lines expressing fluorescent immune cells, immune marker genes or cytokines/chemokines allows the host-pathogen interactions to be characterized.The present study explores the suitability of zebrafish larvae to study the pathogenesis of A. hydrophila and the interaction mechanisms between the bacterium and the innate immune responses through an infection model using different routes for infection. We used an early-embryo infection model at 3 days post-fertilization (dpf through the microinjection of A. hydrophila into the duct of Cuvier, caudal vein, notochord or muscle and two bath infection models using 4 dpf healthy and injured larvae. The latter resembled the natural conditions under which A. hydrophila produces infectious diseases in animals. We compared the cellular processes after infection in each anatomical site by confocal fluorescence imaging and

  12. Study on the establishment of technical standards of radioactive wastes (annual report)

    International Nuclear Information System (INIS)

    Kim, Jhin Wung; Hwang, Y. S.; Kim, S. H.; Yoo, J. H.; Lee, I. H.; Yang, H. B.; Rhim, J. K.

    1997-03-01

    From 1989, KAERI and KINS have worked together to set up national regulations to safely manage radioactive wastes. This year project covers 3 items : 1) post-closure surveillance criteria and closure criteria for disposal of LLW wastes, 2) standard format and contents of safety analysis report for spent fuel interim storage, and 3) review of existing regulations. Results from detailed research shall be used to set up the MOST notices on the safe management of radioactive wastes. Even though this project has been stopped after the national rearrangement on the management of LLW, KINS which jointly has studied this project shall independently study it in the future. (author)

  13. Prospective study establishing a management plan for impacted third molar in patients undergoing hematopoietic stem cell transplantation

    OpenAIRE

    Yamagata, Kenji; Onizawa, Kojiro; Yanagawa, Toru; Takeuchi, Yasutoshi; Hasegawa, Yuichi; Chiba, Shigeru; Bukawa, Hiroki

    2011-01-01

    ObjectiveAlthough dental treatment before hematopoietic stem cell transplantation (HSCT) is essential to prevent serious infections from oral sources, the best management plan for impacted third molar (ITM) is unclear.Study designThis study was planned to establish a management plan for ITM. Eighty-four candidates for HSCT therapy were consecutively enrolled in the prospective trial. The management plan, which was evidence based and prospectively decided, was to extract the symptomatic ITMs a...

  14. Establishing Respectful Educative Relationships: A Study of Newly Qualified Teachers in Ireland

    Science.gov (United States)

    O'Grady, Emmanuel

    2015-01-01

    Interpersonal respect is a fundamental aspect of relating to others. This is especially true for teachers, as cultivating relationships is implicit in effective teaching. This three-year qualitative study examines a developing understanding of respect for pre-service teachers that progresses on to their first year's teaching to examine the…

  15. A Study on establishment of air preservation policy strategy in 21st century

    Energy Technology Data Exchange (ETDEWEB)

    Han, Hwa Jin; Kang, Kwang Kyu; Yoon, Jung Im [Korea Environment Institute, Seoul (Korea)

    1998-12-01

    For the air preservation and entire global environmental preservation in 21st century, it was implemented as a pre-work to maintain clean and clear air quality and to prepare a preventive air preservation policy. This study was focused on proposing the basic strategy of air preservation policy by deriving problems and evaluating actual results. 34 refs., 2 figs., 43 tabs.

  16. Re-Establishing Social Studies as a Core Subject: An Interview with Susan Griffin

    Science.gov (United States)

    Griffin, Susan

    2014-01-01

    NCSS Executive Director Susan Griffin was chair of the Task Force of Professional Organizations that worked with the Social Studies Assessment, Curriculum, and Instruction Collaborative (SSACI) of the Council of Chief State School Officers to initiate and guide the development of the "College, Career and Civic Life (C3) Framework for Social…

  17. 76 FR 45397 - Export Inspection and Weighing Waiver for High Quality Specialty Grain Transported in Containers

    Science.gov (United States)

    2011-07-29

    ...-AB18 Export Inspection and Weighing Waiver for High Quality Specialty Grain Transported in Containers... permanent a waiver due to expire on July 31, 2012, for high quality specialty grain exported in containers... of high quality specialty grain exported in containers are small entities that up until recently...

  18. A top-down approach to fabrication of high quality vertical heterostructure nanowire arrays.

    Science.gov (United States)

    Wang, Hua; Sun, Minghua; Ding, Kang; Hill, Martin T; Ning, Cun-Zheng

    2011-04-13

    We demonstrate a novel top-down approach for fabricating nanowires with unprecedented complexity and optical quality by taking advantage of a nanoscale self-masking effect. We realized vertical arrays of nanowires of 20-40 nm in diameter with 16 segments of complex longitudinal InGaAsP/InP structures. The unprecedented high quality of etched wires is evidenced by the narrowest photoluminescence linewidth ever produced in similar wavelengths, indistinguishable from that of the corresponding wafer. This top-down, mask-free, large scale approach is compatible with the established device fabrication processes and could serve as an important alternative to the bottom-up approach, significantly expanding ranges and varieties of applications of nanowire technology.

  19. A study of students’ travellers values and needs in order to establish futures patterns and insights

    OpenAIRE

    Elena Cavagnaro; Simona Staffieri

    2015-01-01

    Purpose – If the only viable future for tourism is sustainable tourism then ways should be sought to increase the demand for sustainable offers. The purpose of this paper is to explore whether sustainability values influence the travel needs of students. The aim is to discover cues in the present behaviour of young tourists that can enhance sustainable travel choices and therefore secure the future of the tourism industry. Moreover, the study provides a solid basis for predicting the future t...

  20. The Use Of High Speed Photography In Reactor Safety Studies At The Atomic Energy Establishment, Winfrith

    Science.gov (United States)

    Maddison, R. J.

    1985-02-01

    The investigation of certain areas of nuclear reactor safety involves the study of high speed phenomena with timescales ranging from microseconds to a few hundreds of milliseconds. Examples which have been extensively studied at Winfrith are firstly, the thermal interaction of molten fuel and reactor coolant which can generate high pressures on the 100 msec timescale, and which involves phenomena such as vapour film collapse which takes place on the microsecond timescale. Secondly, there is the response of reactor structures to such pressures, and finally there is the response of structural materials such as metals and concrete to the impulsive loading arising from the impact of heavy, high velocity missiles. A wide range of experimental techniques is used in these studies, many of which have been developed specially for this type of work which ranges from small laboratory scale to large field scale experiments. There are two important features which characterise many of these experiments:- i) a long period of meticulous preparation of very heavily instrumented, short duration experiments and; ii) the destructive nature of the experiments. Various forms of High Speed photography are included in the inventory of experimental techniques. These include the use of single and double exposure, short duration, spark photography; the use of an Image Convertor Camera (IMACON 790); and a number of rotating prism cine cameras. High Speed Photography is used both in a primary experimental role in the studies, and in a supportive role for other instrumentation. Because of the sometimes violent nature of these experiments, cameras are often heavily protected and operated remotely; lighting systems are sometimes destroyed. This has led to the development of unconventional techniques for camera operation and subject lighting. This paper will describe some of the experiments and the way in which High Speed Photography has been applied as an essential experimental tool. It will be

  1. What can the lived experience of participating in risky HIV cure-related studies establish?

    Science.gov (United States)

    Eyal, Nir

    2018-04-01

    This response to Gail Henderson et al argues that they were right that interviewees' appraisals of cure study participation should inform (future) protocol review decisions, but wrong to take these appraisals at face value. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  2. Establishing Prostate Cancer Patient Derived Xenografts: Lessons Learned From Older Studies

    OpenAIRE

    Russell, Pamela J; Russell, Peter; Rudduck, Christina; Tse, Brian W-C; Williams, Elizabeth D; Raghavan, Derek

    2015-01-01

    Background Understanding the progression of prostate cancer to androgen-independence/castrate resistance and development of preclinical testing models are important for developing new prostate cancer therapies. This report describes studies performed 30 years ago, which demonstrate utility and shortfalls of xenografting to preclinical modeling. Methods We subcutaneously implanted male nude mice with small prostate cancer fragments from transurethral resection of the prostate (TURP) from 29 pa...

  3. Towards the establishment of a porcine model to study human amebiasis.

    Directory of Open Access Journals (Sweden)

    Fabienne Girard-Misguich

    Full Text Available BACKGROUND: Entamoeba histolytica is an important parasite of the human intestine. Its life cycle is monoxenous with two stages: (i the trophozoite, growing in the intestine and (ii the cyst corresponding to the dissemination stage. The trophozoite in the intestine can live as a commensal leading to asymptomatic infection or as a tissue invasive form producing mucosal ulcers and liver abscesses. There is no animal model mimicking the whole disease cycle. Most of the biological information on E. histolytica has been obtained from trophozoite adapted to axenic culture. The reproduction of intestinal amebiasis in an animal model is difficult while for liver amebiasis there are well-described rodent models. During this study, we worked on the assessment of pigs as a new potential model to study amebiasis. METHODOLOGY/PRINCIPAL FINDINGS: We first co-cultured trophozoites of E. histolytica with porcine colonic fragments and observed a disruption of the mucosal architecture. Then, we showed that outbred pigs can be used to reproduce some lesions associated with human amebiasis. A detailed analysis was performed using a washed closed-jejunal loops model. In loops inoculated with virulent amebas a severe acute ulcerative jejunitis was observed with large hemorrhagic lesions 14 days post-inoculation associated with the presence of the trophozoites in the depth of the mucosa in two out four animals. Furthermore, typical large sized hepatic abscesses were observed in the liver of one animal 7 days post-injection in the portal vein and the liver parenchyma. CONCLUSIONS: The pig model could help with simultaneously studying intestinal and extraintestinal lesion development.

  4. Paediatric traumatic cardiac arrest: a Delphi study to establish consensus on definition and management.

    Science.gov (United States)

    Rickard, Annette C; Vassallo, James; Nutbeam, Tim; Lyttle, Mark D; Maconochie, Ian K; Enki, Doyo G; Smith, Jason E

    2018-04-28

    Paediatric traumatic cardiac arrest (TCA) is associated with low survival and poor outcomes. The mechanisms that underlie TCA are different from medical cardiac arrest; the approach to treatment of TCA may therefore also need to differ to optimise outcomes. The aim of this study was to explore the opinion of subject matter experts regarding the diagnosis and treatment of paediatric TCA, and to reach consensus on how best to manage this group of patients. An online Delphi study was conducted over three rounds, with the aim of achieving consensus (defined as 70% agreement) on statements related to the diagnosis and management of paediatric TCA. Participants were invited from paediatric and adult emergency medicine, paediatric anaesthetics, paediatric ICU and paediatric surgery, as well as Paediatric Major Trauma Centre leads and representatives from the Resuscitation Council UK. Statements were informed by literature reviews and were based on elements of APLS resuscitation algorithms as well as some concepts used in the management of adult TCA; they ranged from confirmation of cardiac arrest to the indications for thoracotomy. 73 experts completed all three rounds between June and November 2016. Consensus was reached on 14 statements regarding the diagnosis and management of paediatric TCA; oxygenation and ventilatory support, along with rapid volume replacement with warmed blood, improve survival. The duration of cardiac arrest and the lack of a response to intervention, along with cardiac standstill on ultrasound, help to guide the decision to terminate resuscitation. This study has given a consensus-based framework to guide protocol development in the management of paediatric TCA, though further work is required in other key areas including its acceptability to clinicians. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  5. Establishment of Lipofection for Studying miRNA Function in Human Adipocytes

    OpenAIRE

    Enlund, Eveliina; Fischer, Simon; Handrick, René; Otte, Kerstin; Debatin, Klaus-Michael; Wabitsch, Martin; Fischer-Posovszky, Pamela

    2014-01-01

    miRNA dysregulation has recently been linked to human obesity and its related complications such as type 2 diabetes. In order to study miRNA function in human adipocytes, we aimed for the modulation of mature miRNA concentration in these cells. Adipocytes, however, tend to be resistant to transfection and there is often a need to resort to viral transduction or electroporation. Our objective therefore was to identify an efficient, non-viral transfection reagent capable of delivering small RNA...

  6. Study on the establishment of efficient plan for regulatory activities at NPPs

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Sang Hun; Son, Mun Gyu [Korea Association for Nuclear Technology, Taejon (Korea, Republic of); Kang, Chang Sun; Yun, Jeong Ik; Ko, Hyun Seok; Lee, Young Wook [Seoul National Univ., Seoul (Korea, Republic of)

    2001-03-15

    In-operation regulatory activities at sites are very important and it should be improved to cope with accidents efficiently and quickly. In case of site survey and safety regulatory inspection regulatory system based on not regulatory headquarter but site regional office should be constructed. In other words, safety assurance and pending problem management considering site situation are needed. In this study, regulatory system at Nuclear Power Plant sites all over the world were reviewed and effective regulatory system of Korea are suggested to maximize the efficiency of license and regulatory manpower and consider the interest of local government and residents.

  7. High-Quality Seismic Observations of Sonic Booms

    Science.gov (United States)

    Wurman, Gilead; Haering, Edward A., Jr.; Price, Michael J.

    2011-01-01

    The SonicBREWS project (Sonic Boom Resistant Earthquake Warning Systems) is a collaborative effort between Seismic Warning Systems, Inc. and NASA Dryden Flight Research Center. This project aims to evaluate the effects of sonic booms on Earthquake Warning Systems in order to prevent such systems from experiencing false alarms due to sonic booms. The airspace above the Antelope Valley, California includes the High Altitude Supersonic Corridor and the Black Mountain Supersonic Corridor. These corridors are among the few places in the US where supersonic flight is permitted, and sonic booms are commonplace in the Antelope Valley. One result of this project is a rich dataset of high-quality accelerometer records of sonic booms which can shed light on the interaction between these atmospheric phenomena and the solid earth. Nearly 100 sonic booms were recorded with low-noise triaxial MEMS accelerometers recording 1000 samples per second. The sonic booms had peak overpressures ranging up to approximately 10 psf and were recorded in three flight series in 2010 and 2011. Each boom was recorded with up to four accelerometers in various array configurations up to 100 meter baseline lengths, both in the built environment and the free field. All sonic booms were also recorded by nearby microphones. We present the results of the project in terms of the potential for sonic-boom-induced false alarms in Earthquake Warning Systems, and highlight some of the interesting features of the dataset.

  8. Construction of High-Quality Camel Immune Antibody Libraries.

    Science.gov (United States)

    Romão, Ema; Poignavent, Vianney; Vincke, Cécile; Ritzenthaler, Christophe; Muyldermans, Serge; Monsion, Baptiste

    2018-01-01

    Single-domain antibodies libraries of heavy-chain only immunoglobulins from camelids or shark are enriched for high-affinity antigen-specific binders by a short in vivo immunization. Thus, potent binders are readily retrieved from relatively small-sized libraries of 10 7 -10 8 individual transformants, mostly after phage display and panning on a purified target. However, the remaining drawback of this strategy arises from the need to generate a dedicated library, for nearly every envisaged target. Therefore, all the procedures that shorten and facilitate the construction of an immune library of best possible quality are definitely a step forward. In this chapter, we provide the protocol to generate a high-quality immune VHH library using the Golden Gate Cloning strategy employing an adapted phage display vector where a lethal ccdB gene has to be substituted by the VHH gene. With this procedure, the construction of the library can be shortened to less than a week starting from bleeding the animal. Our libraries exceed 10 8 individual transformants and close to 100% of the clones harbor a phage display vector having an insert with the length of a VHH gene. These libraries are also more economic to make than previous standard approaches using classical restriction enzymes and ligations. The quality of the Nanobodies that are retrieved from immune libraries obtained by Golden Gate Cloning is identical to those from immune libraries made according to the classical procedure.

  9. High-quality remote interactive imaging in the operating theatre

    Science.gov (United States)

    Grimstead, Ian J.; Avis, Nick J.; Evans, Peter L.; Bocca, Alan

    2009-02-01

    We present a high-quality display system that enables the remote access within an operating theatre of high-end medical imaging and surgical planning software. Currently, surgeons often use printouts from such software for reference during surgery; our system enables surgeons to access and review patient data in a sterile environment, viewing real-time renderings of MRI & CT data as required. Once calibrated, our system displays shades of grey in Operating Room lighting conditions (removing any gamma correction artefacts). Our system does not require any expensive display hardware, is unobtrusive to the remote workstation and works with any application without requiring additional software licenses. To extend the native 256 levels of grey supported by a standard LCD monitor, we have used the concept of "PseudoGrey" where slightly off-white shades of grey are used to extend the intensity range from 256 to 1,785 shades of grey. Remote access is facilitated by a customized version of UltraVNC, which corrects remote shades of grey for display in the Operating Room. The system is successfully deployed at Morriston Hospital, Swansea, UK, and is in daily use during Maxillofacial surgery. More formal user trials and quantitative assessments are being planned for the future.

  10. Production of high quality water for oil sands application

    Energy Technology Data Exchange (ETDEWEB)

    Beaudette-Hodsman, C.; Macleod, B. [Pall Corp., Mississauga, ON (Canada); Venkatadri, R. [Pall Corp., East Hills, NY (United States)

    2008-10-15

    This paper described a pressurized microfiltration membrane system installed at an oil sands extraction site in Alberta. The system was designed to complement a reverse osmosis (RO) system installed at the site to produce the high quality feed water required by the system's boilers. Groundwater in the region exhibited moderate total suspended solids and high alkalinity and hardness levels, and the RO system required feed water with a silt density index of 3 or less. The conventional pretreatment system used at the site was slowing down production due to the severe fouling of the RO membranes. The new microfiltration system contained an automated PVDF hollow fiber microfiltration membrane system contained in a trailer. Suspended particles and bacteria were captured within the filter, and permeate was sent to the RO unit. Within 6 hours of being installed, the unit was producing water with SDI values in the range of 1.0 to 2.5. It was concluded that the microfiltration system performed reliably regardless of wide variations in feed water quality and flow rates. 3 refs., 1 tab., 8 figs.

  11. CCD Astrophotography High-Quality Imaging from the Suburbs

    CERN Document Server

    Stuart, Adam

    2006-01-01

    This is a reference book for amateur astronomers who have become interested in CCD imaging. Those glorious astronomical images found in astronomy magazines might seem out of reach to newcomers to CCD imaging, but this is not the case. Great pictures are attainable with modest equipment. Adam Stuart’s many beautiful images, reproduced in this book, attest to the quality of – initially – a beginner’s efforts. Chilled-chip astronomical CCD-cameras and software are also wonderful tools for cutting through seemingly impenetrable light-pollution. CCD Astrophotography from the Suburbs describes one man’s successful approach to the problem of getting high-quality astronomical images under some of the most light-polluted conditions. Here is a complete and thoroughly tested program that will help every CCD-beginner to work towards digital imaging of the highest quality. It is equally useful to astronomers who have perfect observing conditions, as to those who have to observe from light-polluted city skies.

  12. Establishment of an Institute for Fusion Studies. Technical progress report, November 1, 1994--October 31, 1995

    International Nuclear Information System (INIS)

    1995-07-01

    The Institute for Fusion Studies is a national center for theoretical fusion plasma physics research. Its purposes are to (1) conduct research on theoretical questions concerning the achievement of controlled fusion energy by means of magnetic confinement--including both fundamental problems of long-range significance, as well as shorter-term issues; (2) serve as a national and international center for information exchange by hosting exchange visits, conferences, and workshops; and (3) train students and postdoctoral research personnel for the fusion energy program and plasma physics research areas. During FY 1995, a number of significant scientific advances were achieved at the IFS, both in long-range fundamental problems as well as in near-term strategic issues, consistent with the Institute's mandate. Examples of these achievements include, for example, tokamak edge physics, analytical and computational studies of ion-temperature-gradient-driven turbulent transport, alpha-particle-excited toroidal Alfven eigenmode nonlinear behavior, sophisticated simulations for the Numerical Tokamak Project, and a variety of non-tokamak and non-fusion basic plasma physics applications. Many of these projects were done in collaboration with scientists from other institutions. Research discoveries are briefly described in this report

  13. A Pilot Study Exploring Gender Differences in Residents’ Strategies for Establishing Mentoring Relationships

    Directory of Open Access Journals (Sweden)

    Megan C. McNamara, M.D., MSc

    2008-01-01

    Full Text Available AbstractBackground Mentoring is important throughout a physician’s career and has been noted to be particularly important during residency training. Other studies suggest that women may experience difficulty in finding mentors.Purpose This study explored gender-specific differences in residents’ mentoring experiences.Methods The authors conducted two focus groups at the University of Pittsburgh in July, 2004. One group was composed of 12 female residents; the other was composed of nine male residents. Discussions were audiotaped and transcribed. Two investigators coded the transcripts and identified emerging themes.Results Residents of both genders cited multiple barriers to mentoring. Men´s strategies for findingmentors were more numerous than women´s and included identifying mentors through research,similar interests, friendship, and networking. Female strategies were limited and included identifying mentors through “word of mouth” and work experiences. Women described more passiveapproaches for finding a mentor than men.Conclusions Female residents may lack strategies and initiatives for finding mentors. Residency programs should create opportunities for residents to develop mentoring relationships, with special attention paid to gender differences

  14. Collaborative study for establishment of the European Pharmacopoeia BRP batch 1 for diphtheria toxin.

    Science.gov (United States)

    Sesardic, D; Prior, C; Daas, A; Buchheit, K H

    2003-07-01

    A stable liquid candidate Biological Reference Preparation (BRP) for diphtheria toxin was prepared in peptone buffer (nominal content of diphtheria toxin: 1 Lf/ml, 0.4 micro g/ml), filled in ampoules (filling volume: 1 ml) and characterised in a collaborative study. The toxin is to be used in the test "Absence of toxin and irreversibility of toxoid" as described in the current European Pharmacopoeia (Ph. Eur.) monograph Diphtheria Vaccine (Adsorbed) (2002:0443). Eleven laboratories assessed the specific activity of the preparation by in vivo and in vitro assays. The material is assumed to have satisfactory stability with a calculated predicted loss of activity of LD( 50)/ml (lethal challenge) and >75 000 Lr/Lf (intradermal challenge). The candidate BRP was successfully used in nine laboratories and confirmed suitable for use in the Vero cell test for "Absence of toxin and irreversibility of toxoid" as described in the Ph. Eur. monograph 2002:0443; i.e., concentrations of 5 x 10( -5) Lf/ml and below caused cytotoxic effects in the Vero cell test. Due to its liquid nature, the stability of the material will be monitored at regular intervals and preparation of a stable freeze-dried formulation will be considered for long-term use. Additional studies will be performed to confirm suitability of this BRP for other applications. The candidate BRP was adopted as the Ph. Eur. reference material for Diphtheria Toxin Batch 1 by the Ph. Eur. Commission at its session in March 2003.

  15. THE CONTEXT OF ESTABLISHING PROJECT MANAGEMENT OFFICES IN THE IT AREA: TWO CASE STUDIES

    Directory of Open Access Journals (Sweden)

    Andrea Giovanni Spelta

    2010-01-01

    Full Text Available Completing strategic Information Technology (IT projects as planned is certainly an important objective for large firms. One of the measures adopted to reach this goal systematically is to create a Project Management Office in the IT area (PMO-IT. However, many firms consider the possibility of creating a PMO-IT, but decide not to do it. This paper presents the results of an exploratory research about the contextual drivers that determine the decision to create PMO-Its. Through two case studies of large Brazilian firms – one that created the entity and another which believes does not need it –, the drivers of the decision to create or not to create a PMO-IT were identified, and it was possible to confirm some of the drivers mentioned in the literature. This paper increases the undertstanding about this topic, which is important in the Management Information Systems field, as well as indicates paths for future research.

  16. Study to establish cost predictions for the production of Redox chemicals

    Science.gov (United States)

    Ammann, P. R.; Loreth, M.; Harvey, W. W.

    1982-01-01

    The chromium and iron chloride chemicals are significant first costs for NASA Redox energy storage systems. This study was performed to determine the lowest cost at which chromium and iron chlorides could be obtained for a complex of redox energy storage systems. In addition, since the solutions gradually become intermixed during the course of operation of Redox units, it was an objective to evaluate schemes for regeneration of the operating solutions. Three processes were evaluated for the production of chromium and iron chlorides. As a basis for the preliminary plant design and economic evaluation, it was assumed that the plant would produce about 25,000 tons of contained chromium as CrCl3 and an equivalent molar quantity of FeCl2. Preliminary plant designs, including materials and energy balances and sizing of major equipment, were prepared, and capital and operating costs were estimated.

  17. Establishing an agenda for social studies research in marine renewable energy

    DEFF Research Database (Denmark)

    Watts, Laura; Kerr, Sandy

    2014-01-01

    To date, academic research relating to Marine Renewable Energy (MRE) has largely focused on resource assessment, technical viability and environmental impact. Experiences from onshore renewable energy tell us that social acceptability is equally critical to project success. However, the specific...... nature of the marine environment, patterns of resource distribution and governance means experiences from onshore may not be directly applicable to MRE and the marine environment. This paper sets out an agenda for social studies research linked to MRE, identifying key topics for future research: (i...... research network of social scientists with interests in marine renewable energy. Importantly, this research agenda has been informed by the experiences of developers, regulators and community groups in Orkney. The Orkney archipelago, off the north coast of Scotland, is home to the most intense cluster...

  18. A Case Study of the Bam Earthquake to Establish a Pattern for Earthquake Management in Iran

    Directory of Open Access Journals (Sweden)

    Keramatollah Ziari

    2015-03-01

    Full Text Available The field of crisis management knowledge and expertise is associated with a wide range of fields. Knowledge-based crisis management is a combination of science, art and practice. Iran is an earthquake-prone country. Through years several earthquakes have happened in the country resulting in many human and financial losses. According to scientific standards, the first 24 hours following an earthquake is the most valuable time for saving victims. Yet in the case of Bam only 5% of the victims were rescued within the first 48 hours. The success of disaster management is evaluated in terms of programming, raising public participation, organizing and hiring manpower, and supervising the management process. In this study disaster management is divided into three stages in which different actions are required. The stages and actions are explained in detail. Moreover, features, effects, and losses of the earthquake are described.

  19. Establishment of optimized MDCK cell lines for reliable efflux transport studies.

    Science.gov (United States)

    Gartzke, Dominik; Fricker, Gert

    2014-04-01

    Madin-Darby canine kidney (MDCK) cells transfected with human MDR1 gene (MDCK-MDR1) encoding for P-glycoprotein (hPgp, ABCB1) are widely used for transport studies to identify drug candidates as substrates of this efflux protein. Therefore, it is necessary to rely on constant and comparable expression levels of Pgp to avoid false negative or positive results. We generated a cell line with homogenously high and stable expression of hPgp through sorting single clones from a MDCK-MDR1 cell pool using fluorescence-activated cell sorting (FACS). To obtain control cell lines for evaluation of cross-interactions with endogenous canine Pgp (cPgp) wild-type cells were sorted with a low expression pattern of cPgp in comparison with the MDCK-MDR1. Expression of other transporters was also characterized in both cell lines by quantitative real-time PCR and Western blot. Pgp function was investigated applying the Calcein-AM assay as well as bidirectional transport assays using (3) H-Digoxin, (3) H-Vinblastine, and (3) H-Quinidine as substrates. Generated MDCK-MDR1 cell lines showed high expression of hPgp. Control MDCK-WT cells were optimized in showing a comparable expression level of cPgp in comparison with MDCK-MDR1 cell lines. Generated cell lines showed higher and more selective Pgp transport compared with parental cells. Therefore, they provide a significant improvement in the performance of efflux studies yielding more reliable results. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association.

  20. Establishing state of motion through two-dimensional foot and shoe print analysis: A pilot study.

    Science.gov (United States)

    Neves, Fernando Bueno; Arnold, Graham P; Nasir, Sadiq; Wang, Weijie; MacDonald, Calum; Christie, Ian; Abboud, Rami J

    2018-03-01

    According to the College of Podiatry, footprints rank among the most frequent forms of evidence found at crime scenes, and the recent ascension of forensic podiatry reflects the importance of footwear and barefoot traces in contemporary forensic practice. In this context, this pilot study focused on whether it is possible to distinguish between walking and running states using parameters derived from two-dimensional foot or shoe prints. Eleven subjects moved along four tracks (barefoot walking; barefoot running; footwear walking; footwear running) while having their bare feet or footwear stained with artificial blood and their footstep patterns recorded. Contact stains and associated bloodstain patterns were collected, and body movements were recorded through three-dimensional motion capture. Barefoot walking prints were found to be larger than barefoot static prints (1.789±0.481cm; pprints (0.635±0.405cm; p=0.006). No correlation was observed for footwear prints. Running trials were more associated with the presence of both passive and cast off stains than walking trials, and the quantity of additional associated stains surrounding individual foot and shoe prints was also higher in running states. Furthermore, a previously proposed equation predicted speed with a high degree of accuracy (within 6%) and may be used for clinical assessment of walking speed. Contact stains, associated bloodstain patterns and stride length measurements may serve to ascertain state of motion in real crime scene scenarios, and future studies may be capable of designing statistical frameworks which could be used in courts of law. Copyright © 2018 Elsevier B.V. All rights reserved.

  1. Preconditions needed for establishing a trusting relationship during health counselling - an interview study.

    Science.gov (United States)

    Eriksson, Irene; Nilsson, Kerstin

    2008-09-01

    To examine the preconditions needed by district nurses to build a trusting relationship during health counselling of patients with hypertension. Trust has been found to be an important aspect of the patient-nurse relationship. Little research has focused on how trust is formed in patient-nurse relationships or the conditions the development process requires when working with health counselling; in particular not in relation to hypertension. Qualitative study. Qualitative data were collected through open-ended interviews with all (10) district nurses from three primary health care districts of western Sweden. All interviewees work with the health counselling of patients with hypertension. A latent content analysis was performed with thematic coding of the content of the interviews. The first theme that emerged from the analysis, the nurses' competence, describes the nurses' consciousness of their method of expression, both oral and non-verbal, as well as their pedagogical competence and their ability to be reliable in their profession. The second theme, the patient meeting, describes the continuity in the patient meeting and creating respectful communication. The results show an awareness of preconditions influencing building a trusting relationship. When creating a trusting relationship the communication and pedagogical competences of district nurses have considerable importance. Despite this awareness they state that it is easy to fall into a routinised way of working. The implications of this study might be used as support and guidance for district nurses when developing their competence in health counselling in relations to patients with hypertension. This knowledge is also important when planning for nurse-led clinics for this patient group.

  2. Establishment of lipofection for studying miRNA function in human adipocytes.

    Science.gov (United States)

    Enlund, Eveliina; Fischer, Simon; Handrick, René; Otte, Kerstin; Debatin, Klaus-Michael; Wabitsch, Martin; Fischer-Posovszky, Pamela

    2014-01-01

    miRNA dysregulation has recently been linked to human obesity and its related complications such as type 2 diabetes. In order to study miRNA function in human adipocytes, we aimed for the modulation of mature miRNA concentration in these cells. Adipocytes, however, tend to be resistant to transfection and there is often a need to resort to viral transduction or electroporation. Our objective therefore was to identify an efficient, non-viral transfection reagent capable of delivering small RNAs into these cells. To achieve this, we compared the efficiencies of three transfection agents, Lipofectamine 2000, ScreenFect A and BPEI 1.2 k in delivering fluorescent-labelled siRNA into human Simpson-Golabi-Behmel syndrome (SGBS) preadipocytes and adipocytes. Downregulation of a specific target gene in response to miRNA mimic overexpression was assayed in SGBS cells and also in ex vivo differentiated primary human adipocytes. Our results demonstrated that while all three transfection agents were able to internalize the oligos, only lipofection resulted in the efficient downregulation of a specific target gene both in SGBS cells and in primary human adipocytes. Lipofectamine 2000 outperformed ScreenFect A in preadipocytes, but in adipocytes the two reagents gave comparable results making ScreenFect A a notable new alternative for the gold standard Lipofectamine 2000.

  3. Establishment of lipofection for studying miRNA function in human adipocytes.

    Directory of Open Access Journals (Sweden)

    Eveliina Enlund

    Full Text Available miRNA dysregulation has recently been linked to human obesity and its related complications such as type 2 diabetes. In order to study miRNA function in human adipocytes, we aimed for the modulation of mature miRNA concentration in these cells. Adipocytes, however, tend to be resistant to transfection and there is often a need to resort to viral transduction or electroporation. Our objective therefore was to identify an efficient, non-viral transfection reagent capable of delivering small RNAs into these cells. To achieve this, we compared the efficiencies of three transfection agents, Lipofectamine 2000, ScreenFect A and BPEI 1.2 k in delivering fluorescent-labelled siRNA into human Simpson-Golabi-Behmel syndrome (SGBS preadipocytes and adipocytes. Downregulation of a specific target gene in response to miRNA mimic overexpression was assayed in SGBS cells and also in ex vivo differentiated primary human adipocytes. Our results demonstrated that while all three transfection agents were able to internalize the oligos, only lipofection resulted in the efficient downregulation of a specific target gene both in SGBS cells and in primary human adipocytes. Lipofectamine 2000 outperformed ScreenFect A in preadipocytes, but in adipocytes the two reagents gave comparable results making ScreenFect A a notable new alternative for the gold standard Lipofectamine 2000.

  4. Lessons learnt from a feasibility study on price incentivised healthy eating promotions in workplace catering establishments.

    Science.gov (United States)

    Mackison, D; Mooney, J; Macleod, M; Anderson, A S

    2016-02-01

    It is recognised that the worksite catering sector is likely to play a pivotal role in influencing dietary intake in adults of working age. The present study aimed to assess the feasibility of engaging worksites in a healthy eating intervention, implementing a price incentivised main meal intervention and measuring indicative intervention responses to inform the design of a future trial. Workplaces registered with the Scottish Healthy Living Award were invited to participate. The EatSMART intervention (a reduced price, healthy meal combination plus promotions) was implemented over 10 weeks in two worksites. Implementation was assessed by observational and sales data. Indicative effects on food habits were measured using online pre- and post-intervention questionnaires. Focus group discussions and interviews were used to determine catering staff and consumer acceptability. Thirty-seven worksites were invited to participate and four worksites responded positively. Two sites (with 1600 and 500 employees, respectively) participated. Both required significant implementation support. Estimated sales data indicated that the uptake of promoted items varied by week (range 60-187 items) and by site. A poor response rate from questionnaires limited the evaluation of intervention impact. Consumers reported improved value for money and quality. Both sites reported an intention to continue the intervention delivery. Significant efforts are required to engage worksite catering teams and implement healthy eating interventions. Evaluation methods require further development to improve data collection. Responses from consumers and catering staff suggest that further work in this area would be welcomed. © 2014 The British Dietetic Association Ltd.

  5. A study on coated particle fuel properties and performances and phase-I data base establishment

    International Nuclear Information System (INIS)

    Kim, Yong Soo; Lee, Hyo Cheol; Im, Byeong Ju; Yun, Sang Pil; Son, Seung Beom; Lee, Gyeong Hui; Jang, Jeong Nam

    2006-03-01

    For the successful development of the high temperature gas cooled reactor acquisition and generation of the high temperature properties of reactor materials, especially temperature and burn-up dependent properties of coated particle fuel and fuel element, are crucially essential. Recently national project for HTGR for hydrogen production has been kicked off. However, we have had little experience on this new challenges. Therefore, it became necessary to build up the materials properties and fuel performance data base. In this study, a primitive properties and performance DB for coated particle fuel was developed. This database report consists two sections: materials properties and fuel performance. The materials properties has three parts: kernel materials, carbide coating materials, and fuel elements and graphite matrix. UO 2 and UCO belong to kernel materials while PyC, SiC, and ZrC comprises the coating materials section. Thermal, mechanical and physical properties of these materials were collected, reviewed, and summarized. Additionally, the property change induced by manufacture process and irradiation were collected and summarized. Performance data were also collected, reviewed, and analyzed based on the key phenomena and failure mechanism. All of these data will be accessible in the on-line system. These results will be directly used for HTGR fuel design and fabrication and preliminary fuel performance analysis under irradiation

  6. A study on properties-performances of coated particle fuel and on-line DB establishment

    International Nuclear Information System (INIS)

    Kim, Yong Soo; Lee, Hyo Cheol; Jang, Jeong Nam; Kwon, Seok Hwan

    2007-03-01

    Recently national project for HTGR for hydrogen production has been kicked off. However, For the successful development of the high temperature gas cooled reactor high temperature and burn-up dependent properties of the reactor materials are essentially and crucially required. Therefore, it was proposed to build up the materials properties and fuel performance data base. In this study, a phase - 1 properties and performance DB for coated particle fuel was developed. This database report consists two sections: materials properties and fuel performance. The materials properties has three parts: kernel materials, carbide coating materials, and fuel elements and graphite matrix. UO2 and UCO belong to kernel materials while PyC, SiC, and ZrC comprises the coating materials section. Thermal, mechanical and physical properties data of these materials were collected, reviewed, and summarized. Additionally, the property change induced by manufacture process and irradiation were reviewed. Fuel performance data were also collected, reviewed, and analyzed based on the key phenomena and failure mechanism, These performance data are divided into two: normal and accident. All of these data will be accessible in the pc based stand-alone system. These results will be directly used for HTGR fuel design and fabrication and preliminary fuel performance analysis under irradiation

  7. Establishing a ultraviolet radiation observational network and enhancing the study on ultraviolet radiation

    Science.gov (United States)

    Bai, Jianhui; Wang, Gengchen

    2003-09-01

    On the basis of analyzing observational data on solar radiation, meteorological parameters, and total ozone amount for the period of January 1990 to December 1991 in the Beijing area, an empirical calculation method for ultraviolet radiation (UV) in clear sky is obtained. The results show that the calculated values agree well with the observed, with maximum relative bias of 6.2% and mean relative bias for 24 months of 1.9%. Good results are also obtained when this method is applied in Guangzhou and Mohe districts. The long-term variation of UV radiation in clear sky over the Beijing area from 1979 to 1998 is calculated, and the UV variation trends and causes are discussed: direct and indirect UV energy absorption by increasing pollutants in the troposphere may have caused the UV decrease in clear sky in the last 20 years. With the enhancement of people’s quality of life and awareness of health, it will be valuable and practical to provid UV forecasts for typical cities and rural areas. So, we should develop and enhance UV study in systematic monitoring, forecasting, and developing a good and feasible method for UV radiation reporting in China, especially for big cities.

  8. The acceptability of community leaders in establishing a nuclear power plant in Thailand: a case study of Chumphon province

    International Nuclear Information System (INIS)

    Aukaravarothai, A.

    1998-01-01

    Acceptability of community leaders regarding the establishment of a nuclear power plant in Amphoe Pathiu of Chumphon Province in studied. The objectives are to investigate the level of understanding, the attitudes of acceptance and the possible benefits the community expects from the establishment of a nuclear power plant in the province. The study method involved interviewing the selected 118 community leaders and then applying the statistical method to analysis their responses and obtain a general description of the acceptability. The Chi-quire method was used to test the hypothesis at the confidence levels of 95% and 99%. The results revealed that 88.1% of the respondents were male and 11.9% were female, 88.2% have lived there permanently, 39.8% were university graduates and 48.3% are government officials, 48.3% were acceptable about the establishment of the nuclear power plant, 54.2% were not acceptable and 29.7% were ambiguous because they were afraid and uncertain about the safety of the power plant. In the acceptable group there was no correlation between the responses and the general Background of the respondents, i.e. age, occupation, education and field of study. However, in the unacceptable and ambiguous groups, a correlation was found between their responses and general background. This could be due to an information drive in the community prior to this study

  9. A Rapid and Efficient Method for Purifying High Quality Total RNA from Peaches (Prunus persica for Functional Genomics Analyses

    Directory of Open Access Journals (Sweden)

    LEE MEISEL

    2005-01-01

    Full Text Available Prunus persica has been proposed as a genomic model for deciduous trees and the Rosaceae family. Optimized protocols for RNA isolation are necessary to further advance studies in this model species such that functional genomics analyses may be performed. Here we present an optimized protocol to rapidly and efficiently purify high quality total RNA from peach fruits (Prunus persica. Isolating high-quality RNA from fruit tissue is often difficult due to large quantities of polysaccharides and polyphenolic compounds that accumulate in this tissue and co-purify with the RNA. Here we demonstrate that a modified version of the method used to isolate RNA from pine trees and the woody plant Cinnamomun tenuipilum is ideal for isolating high quality RNA from the fruits of Prunus persica. This RNA may be used for many functional genomic based experiments such as RT-PCR and the construction of large-insert cDNA libraries.

  10. Establishment and operation of a biorepository for molecular epidemiologic studies in Costa Rica.

    Science.gov (United States)

    Cortés, Bernal; Schiffman, Mark; Herrero, Rolando; Hildesheim, Allan; Jiménez, Silvia; Shea, Katheryn; González, Paula; Porras, Carolina; Fallas, Greivin; Rodríguez, Ana Cecilia

    2010-04-01

    The Proyecto Epidemiológico Guanacaste (PEG) has conducted several large studies related to human papillomavirus (HPV) and cervical cancer in Guanacaste, Costa Rica in a long-standing collaboration with the U.S. National Cancer Institute. To improve molecular epidemiology efforts and save costs, we have gradually transferred technology to Costa Rica, culminating in state-of-the-art laboratories and a biorepository to support a phase III clinical trial investigating the efficacy of HPV 16/18 vaccine. Here, we describe the rationale and lessons learned in transferring molecular epidemiologic and biorepository technology to a developing country. At the outset of the PEG in the early 1990s, we shipped all specimens to repositories and laboratories in the United States, which created multiple problems. Since then, by intensive personal interactions between experts from the United States and Costa Rica, we have successfully transferred liquid-based cytology, HPV DNA testing and serology, chlamydia and gonorrhea testing, PCR-safe tissue processing, and viable cryopreservation. To accommodate the vaccine trial, a state-of-the-art repository opened in mid-2004. Approximately 15,000 to 50,000 samples are housed in the repository on any given day, and >500,000 specimens have been shipped, many using a custom-made dry shipper that permits exporting >20,000 specimens at a time. Quality control of shipments received by the NCI biorepository has revealed an error rate of storage of frozen specimens returned from the United States. Using Internet-based specimen tracking software has proven to be efficient even across borders. For long-standing collaborations, it makes sense to transfer the molecular epidemiology expertise toward the source of specimens. The successes of the PEG molecular epidemiology laboratories and biorepository prove that the physical and informatics infrastructures of a modern biorepository can be transferred to a resource-limited and weather

  11. A study of students’ travellers values and needs in order to establish futures patterns and insights

    Directory of Open Access Journals (Sweden)

    Elena Cavagnaro

    2015-03-01

    Full Text Available Purpose – If the only viable future for tourism is sustainable tourism then ways should be sought to increase the demand for sustainable offers. The purpose of this paper is to explore whether sustainability values influence the travel needs of students. The aim is to discover cues in the present behaviour of young tourists that can enhance sustainable travel choices and therefore secure the future of the tourism industry. Moreover, the study provides a solid basis for predicting the future travel behaviour of young tourists. Design/methodology/approach – Data were collected in The Netherlands in 2013 through a survey. A non‐probabilistic sample of 365 students (a sub‐group of young tourists was reached. Multivariate analyses were used to test whether position in the social structure and value orientation influence the travel need. The logistic models allowed youth tourism behaviour to be predicted. Findings – Respondents with a biospheric value orientation associate travel with being in contact with nature and chose rest as a motivation. This is highly interesting from a future perspective because biospheric values are considered the most stable antecedent of sustainable behaviour. Findings also highlight women's role as the sustainable tourists of the future: women harbour strong sustainability values and see travel as a growth opportunity. Research limitations/implications – This research focuses on travel needs because this is the most future‐oriented phase of the tourism experience, and on students because they tend to travel independently. Future research might include travel consumption and evaluation as well as non‐students in the sample to give a more balanced view on young tourists. Future research might also include values not related to sustainability to assess their relative strengths in influencing youth tourism. Practical implications – Both policy makers and industry could capitalise on the sustainability values

  12. Establishing the reliability and validity of the Zagazig Depression Scale in a UK student population: an online pilot study

    OpenAIRE

    Ibrahim, Ahmed K; Kelly, Shona J; Challenor, Emily C; Glazebrook, Cris

    2010-01-01

    Abstract Background It is thought that depressive disorders will be the second leading cause of disability worldwide by 2020. Recently, there is a steady increase in the number of university students diagnosed and treated as depression patients. It can be assumed that depression is a serious mental health problem for university students because it affects all age groups of the students either younger or older equally. The current study aims to establish the reliability and validity of the Zag...

  13. Comparison of apical extrusion of intracanal bacteria by various glide-path establishing systems: an in vitro study

    Directory of Open Access Journals (Sweden)

    Alberto Dagna

    2017-11-01

    Full Text Available Objectives This study compared the amount of apically extruded bacteria during the glide-path preparation by using multi-file and single-file glide-path establishing nickel-titanium (NiTi rotary systems. Materials and Methods Sixty mandibular first molar teeth were used to prepare the test apparatus. They were decoronated, blocked into glass vials, sterilized in ethylene oxide gas, infected with a pure culture of Enterococcus faecalis, randomly assigned to 5 experimental groups, and then prepared using manual stainless-steel files (group KF and glide-path establishing NiTi rotary files (group PF with PathFiles, group GF with G-Files, group PG with ProGlider, and group OG with One G. At the end of canal preparation, 0.01 mL NaCl solution was taken from the experimental vials. The suspension was plated on brain heart infusion agar and colonies of bacteria were counted, and the results were given as number of colony-forming units (CFU. Results The manual instrumentation technique tested in group KF extruded the highest number of bacteria compared to the other 4 groups (p < 0.05. The 4 groups using rotary glide-path establishing instruments extruded similar amounts of bacteria. Conclusions All glide-path establishment instrument systems tested caused a measurable apical extrusion of bacteria. The manual glide-path preparation showed the highest number of bacteria extruded compared to the other NiTi glide-path establishing instruments.

  14. Fast Synthesis of High Quality Biodiesel from ‘Waste Fish Oil’ by Single Step Transesterification

    Directory of Open Access Journals (Sweden)

    Yogesh C. Sharma

    2014-09-01

    Full Text Available A large volume of fish wastes is produced on a daily basis in the Indian sub-continent. This abundant waste source could serve as an economic feedstock for bioenergy generation. In the present study, oil extracted from discarded fish parts was used for high quality biodiesel production. More specifically, a single step transesterification of ‘waste fishoil’ with methanol using sodium methoxide (CH3ONa as homogeneous catalyst under moderate operational conditions resulted in highly pure biodiesel of > 98% of fatty acid methyl ester (FAME content. Characterization was performed by Fourier Transform-Nuclear Magnetic Resonance (FT-NMR.

  15. A hybrid plasmonic microresonator with high quality factor and small mode volume

    International Nuclear Information System (INIS)

    Lu, Qijing; Chen, Daru; Wu, Genzhu; Peng, Baojin; Xu, Jiancheng

    2012-01-01

    We propose a novel hybrid plasmonic microcavity which is composed of a silver nanoring and a silica toroidal microcavity. The hybrid mode of the proposed hybrid plasmonic microcavity due to the coupling between the surface plasmon polaritons (SPPs) and the dielectric mode is demonstrated with a high quality factor (>1000) and an ultrasmall mode volume (∼0.8 μm 3 ). This microcavity shows great potential in fundamental studies of nonlinear optics and cavity quantum electrodynamics (cQED) and applications in low-threshold plasmonic microlasers. (paper)

  16. Recruiting and retaining high-quality teachers in rural areas.

    Science.gov (United States)

    Monk, David H

    2007-01-01

    In examining recruitment and retention of teachers in rural areas, David Monk begins by noting the numerous possible characteristics of rural communities--small size, sparse settlement, distance from population concentrations, and an economic reliance on agricultural industries that are increasingly using seasonal and immigrant workers to minimize labor costs. Many, though not all, rural areas, he says, are seriously impoverished. Classes in rural schools are relatively small, and teachers tend to report satisfaction with their work environments and relatively few problems with discipline. But teacher turnover is often high, and hiring can be difficult. Monk observes that rural schools have a below-average share of highly trained teachers. Compensation in rural schools tends to be low, perhaps because of a lower fiscal capacity in rural areas, thus complicating efforts to attract and retain teachers. Several student characteristics, including relatively large shares of students with special needs and with limited English skills and lower shares of students attending college, can also make it difficult to recruit and retain high-quality teachers. Other challenges include meeting the needs of highly mobile children of low-income migrant farm workers. With respect to public policy, Monk asserts a need to focus on a subcategory of what might be called hard-to-staff rural schools rather than to develop a blanket set of policies for all rural schools. In particular, he recommends a focus on such indicators as low teacher qualifications, teaching in fields far removed from the area of training, difficulty in hiring, high turnover, a lack of diversity among teachers in the school, and the presence of migrant farm workers' children. Successful efforts to stimulate economic growth in these areas would be highly beneficial. He also calls attention to the potential for modern telecommunication and computing technologies to offset some of the drawbacks associated with teaching

  17. A Pilot Study On The Sustainability Of The Engineers’ Technical Knowledge Repository (KR Establishment: A Malaysian Case

    Directory of Open Access Journals (Sweden)

    Siti Arpah Binti Noordin

    2015-12-01

    Full Text Available Knowledge is an important resource in this current economic condition where organizations are competing in creating more innovation in order to maintain their business in the marketplace. Thus, it is important for an establishment to continue their capitalizing their knowledge asset as knowledge is vital to gain competitive advantage in this current epoch. With regards to that, an organization needs to plan and design the most appropriate approach which enable the organizational knowledge asset to be captured, stored and utilized its valuable benefits. Establishing a knowledge repository (KR is one of the approaches organizations adapt in maintaining organizational knowledge asset and promoting knowledge reuse. The focal point of this research is on the sustainability of knowledge repository establishment in sharing, transferring, storing the technical knowledge of the key personnel from the Malaysian public sector. The study adopted the qualitative research approach as its aim is to look into the sustainability of KR in an in-depth manner which concerned with the societal facet of that particular system. Therefore, the paper discusses the outcomes from the pilot study on which elements that sustain the significant impact in contributing to the process of knowledge repository sustainability in an organization.

  18. Establishing error management process for power plants. A study on entire picture of the process and introduction stages

    International Nuclear Information System (INIS)

    Hirotsu, Yuko; Fujimoto, Junzo; Sugihara, Yoshikuni; Takeda, Daisuke

    2009-01-01

    The purpose of this study is to establish a management process for a power plant to positively find out actual and/or potential problems that may possibility cause a serious human factor event, and to take effective measures. Firstly, detail steps for error management process utilizing human factor event data has been examined through an application at a plant. Secondly, basic steps for evaluating the degree of execution, enhancement and usefulness of each human performance activity and for identifying unsafe acts and uneasy human performance states were established based on literature searching and our experiences on plant evaluation. Finally, an entire picture of error management process was proposed by unifying the steps studied above. In addition, as stages for introducing and establishing the above proposed error management process into a power plant, a basic idea of supplementing an insufficient part of the process with a phased approach after comparing the above proposed management process and the existing human performance activities at the plant was introduced. (author)

  19. Different paths to high-quality care: three archetypes of top-performing practice sites.

    Science.gov (United States)

    Feifer, Chris; Nemeth, Lynne; Nietert, Paul J; Wessell, Andrea M; Jenkins, Ruth G; Roylance, Loraine; Ornstein, Steven M

    2007-01-01

    Primary care practices use different approaches in their quest for high-quality care. Previous work in the Practice Partner Research Network (PPRNet) found that improved outcomes are associated with strategies to prioritize performance, involve staff, redesign elements of the delivery system, make patients active partners in guideline adherence, and use tools embedded in the electronic medical record. The aim of this study was to examine variations in the adoption of improvements among sites achieving the best outcomes. This study used an observational case study design. A practice-level measure of adherence to clinical guidelines was used to identify the highest performing practices in a network of internal and family medicine practices participating in a national demonstration project. We analyzed qualitative and quantitative information derived from project documents, field notes, and evaluation questionnaires to develop and compare case studies. Nine cases are described. All use many of the same improvement strategies. Differences in the way improvements are organized define 3 distinct archetypes: the Technophiles, the Motivated Team, and the Care Enterprise. There is no single approach that explains the superior performance of high-performing practices, though each has adopted variations of PPRNet's improvement model. Practices will vary in their path to high-quality care. The archetypes could prove to be a useful guide to other practices selecting an overall quality improvement approach.

  20. High quality copy number and genotype data from FFPE samples using Molecular Inversion Probe (MIP) microarrays

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Yuker; Carlton, Victoria E.H.; Karlin-Neumann, George; Sapolsky, Ronald; Zhang, Li; Moorhead, Martin; Wang, Zhigang C.; Richardson, Andrea L.; Warren, Robert; Walther, Axel; Bondy, Melissa; Sahin, Aysegul; Krahe, Ralf; Tuna, Musaffe; Thompson, Patricia A.; Spellman, Paul T.; Gray, Joe W.; Mills, Gordon B.; Faham, Malek

    2009-02-24

    A major challenge facing DNA copy number (CN) studies of tumors is that most banked samples with extensive clinical follow-up information are Formalin-Fixed Paraffin Embedded (FFPE). DNA from FFPE samples generally underperforms or suffers high failure rates compared to fresh frozen samples because of DNA degradation and cross-linking during FFPE fixation and processing. As FFPE protocols may vary widely between labs and samples may be stored for decades at room temperature, an ideal FFPE CN technology should work on diverse sample sets. Molecular Inversion Probe (MIP) technology has been applied successfully to obtain high quality CN and genotype data from cell line and frozen tumor DNA. Since the MIP probes require only a small ({approx}40 bp) target binding site, we reasoned they may be well suited to assess degraded FFPE DNA. We assessed CN with a MIP panel of 50,000 markers in 93 FFPE tumor samples from 7 diverse collections. For 38 FFPE samples from three collections we were also able to asses CN in matched fresh frozen tumor tissue. Using an input of 37 ng genomic DNA, we generated high quality CN data with MIP technology in 88% of FFPE samples from seven diverse collections. When matched fresh frozen tissue was available, the performance of FFPE DNA was comparable to that of DNA obtained from matched frozen tumor (genotype concordance averaged 99.9%), with only a modest loss in performance in FFPE. MIP technology can be used to generate high quality CN and genotype data in FFPE as well as fresh frozen samples.

  1. The Effects of Using the Essential Skills Inventory on Teacher Perception of High-Quality Classroom Instruction

    Science.gov (United States)

    Sornson, Bob

    2015-01-01

    This study explores the efficacy of using the Essential Skill Inventories (ESI) to increase high-quality instruction in the early learning years. Kindergarten and first- and second-grade teachers, who were identified as using the ESI with fidelity, assessed their own teaching skills and behaviors, reflecting on these before and after use of the…

  2. Competition for pulsed resources: an experimental study of establishment and coexistence for an arid-land grass.

    Science.gov (United States)

    Jankju-Borzelabad, Mohammad; Griffiths, Howard

    2006-07-01

    In arid environments, episodically-pulsed resources are important components of annual water and nutrient supply for plants. This study set out to test whether seedlings have an increased capacity for using pulsed resources, which might then improve establishment when in competition with older individuals. A second aim was to determine whether there is a trade-off in competitive strategies when resources are supplied continuously at low concentrations, or as pulses with pronounced inter-pulse periods. A glasshouse experiment used a target-neighbour design of size-asymmetric competition, with juveniles of Panicum antidotale (blue panicgrass) introduced into contrasting densities of adult plants. Stable isotopes of nitrogen were used for measuring plant resource uptake from pulses, and tolerance to inter-pulse conditions was assessed as the mean residence time (MRT) of nitrogen. A higher root/shoot ratio and finer root system enhanced the capacity of juveniles to use resources when pulsed, rather than when continuously supplied. Higher resource uptake during pulses improved the establishment of juvenile Panicum in mixed cultures with older individuals. However, a trade-off was observed in plant strategies, with juveniles showing a lower MRT for nitrogen, which suggested reduced tolerance to resource deficit during inter-pulse periods. Under field conditions, higher utilization of pulsed resources would lead to the improved seedling establishment of Panicum adjacent to "nurse" plants, whereas mature plants with well-developed roots, exploiting a greater soil volume, maintain more constant resource uptake and retention during inter-pulse periods.

  3. Establishing and sustaining research partnerships in Africa: a case study of the UK-Africa Academic Partnership on Chronic Disease

    Directory of Open Access Journals (Sweden)

    de-Graft Aikins Ama

    2012-08-01

    Full Text Available Abstract This paper examines the challenges and opportunities in establishing and sustaining north–south research partnerships in Africa through a case study of the UK-Africa Academic Partnership on Chronic Disease. Established in 2006 with seed funding from the British Academy, the partnership aimed to bring together multidisciplinary chronic disease researchers based in the UK and Africa to collaborate on research, inform policymaking, train and support postgraduates and create a platform for research dissemination. We review the partnership’s achievements and challenges, applying established criteria for developing successful partnerships. During the funded period we achieved major success in creating a platform for research dissemination through international meetings and publications. Other goals, such as engaging in collaborative research and training postgraduates, were not as successfully realised. Enabling factors included trust and respect between core working group members, a shared commitment to achieving partnership goals, and the collective ability to develop creative strategies to overcome funding challenges. Barriers included limited funding, administrative support, and framework for monitoring and evaluating some goals. Chronic disease research partnerships in low-income regions operate within health research, practice, funding and policy environments that prioritise infectious diseases and other pressing public health and developmental challenges. Their long-term sustainability will therefore depend on integrated funding systems that provide a crucial capacity building bridge. Beyond the specific challenges of chronic disease research, we identify social capital, measurable goals, administrative support, creativity and innovation and funding as five key ingredients that are essential for sustaining research partnerships.

  4. Establishing and sustaining research partnerships in Africa: a case study of the UK-Africa Academic Partnership on Chronic Disease

    Science.gov (United States)

    2012-01-01

    This paper examines the challenges and opportunities in establishing and sustaining north–south research partnerships in Africa through a case study of the UK-Africa Academic Partnership on Chronic Disease. Established in 2006 with seed funding from the British Academy, the partnership aimed to bring together multidisciplinary chronic disease researchers based in the UK and Africa to collaborate on research, inform policymaking, train and support postgraduates and create a platform for research dissemination. We review the partnership’s achievements and challenges, applying established criteria for developing successful partnerships. During the funded period we achieved major success in creating a platform for research dissemination through international meetings and publications. Other goals, such as engaging in collaborative research and training postgraduates, were not as successfully realised. Enabling factors included trust and respect between core working group members, a shared commitment to achieving partnership goals, and the collective ability to develop creative strategies to overcome funding challenges. Barriers included limited funding, administrative support, and framework for monitoring and evaluating some goals. Chronic disease research partnerships in low-income regions operate within health research, practice, funding and policy environments that prioritise infectious diseases and other pressing public health and developmental challenges. Their long-term sustainability will therefore depend on integrated funding systems that provide a crucial capacity building bridge. Beyond the specific challenges of chronic disease research, we identify social capital, measurable goals, administrative support, creativity and innovation and funding as five key ingredients that are essential for sustaining research partnerships. PMID:22897937

  5. DSA-guided embolization in establishing different canine spinal cord ischemia models and relevant diffusion-weighted imaging study

    International Nuclear Information System (INIS)

    Zhang Jingsong; Sun Lijun; Huan Yi; He Hongde; Zhang Xuexin; Zhao Haitao; Zhang Jing; Zhang Xijing

    2006-01-01

    Objective: To evaluate DSA-guided embolization in establishing different spinal cord ischemia models of canine and relevant diffusion-weighted imaging (DWI) application. Methods: Nine canines were randomly divided into three groups with different matching of lipiodol and diatrizoate meglumine which were injected into bilateral intercostal arteries at 9-11 level guided by DSA monitor. Then observe the changes of motor function and pathologic findings, especially perform routine MRI and DWI by a 1.5 T MR system. Results: Except one case, 8 embolization models were established successfully. Among three groups, slight-group got slight injury and muscle power was about 3-5 grade and range of injury was about two vertebra distance; medium-group presented obvious paraplegia and muscle power was 0-1 grade and range of injury was between 3-4 vertebra distance; severe-group showed greater severity and larger range of injury. All lesions presented high signals at routine MRI and DWI. Conclusion: Using different matching of lipiodol and diatrizoate meglumine can establish different spinal cord ischemia models of canine by DSA- guided embolization and DWI can be performed successfully by 1.5 T MR system, which may be a good method for advanced study of spinal cord ischemia. (authors)

  6. New developments in high quality grey cast irons

    Directory of Open Access Journals (Sweden)

    Iulian Riposan

    2014-07-01

    Full Text Available The paper reviews original data obtained by the present authors, revealed in recent separate publications, describing specific procedures for high quality grey irons, and reflecting the forecast needs of the worldwide iron foundry industry. High power, medium frequency coreless induction furnaces are commonly used in electric melting grey iron foundries. This has resulted in low sulphur (1,500 °C, contributing to unfavourable conditions for graphite nucleation. Thin wall castings are increasingly produced by these electric melt shops with a risk of greater eutectic undercooling during solidification. The paper focused on two groups of grey cast irons and their specific problems: carbides and graphite morphology control in lower carbon equivalent high strength irons (CE=3.4%-3.8%, and austenite dendrite promotion in eutectic and slightly hypereutectic irons (CE=4.1%-4.5%, in order to increase their strength characteristics. There are 3 stages and 3 steps involving graphite formation, iron chemistry and iron processing that appear to be important. The concept in the present paper sustains a threestage model for nucleating flake graphite [(Mn,XS type nuclei]. There are three important groups of elements (deoxidizer, Mn/S, and inoculant and three technological stages in electric melting of iron (superheat, pre-conditioning of base iron, final inoculation. Attention is drawn to a control factor (%Mn x (%S ensuring it equals to 0.03 – 0.06, accompanied by 0.005wt.%–0.010wt.% Al and/or Zr content in inoculated irons. It was found that iron powder addition promotes austenite dendrite formation in eutectic and slightly eutectic, acting as reinforcement for the eutectic cells. But, there is an accompanying possible negative influence on the characteristics of the (Mn,XS type graphite nuclei (change the morphology of nuclei from polygonal compact to irregular polygonal, and therefore promote chill tendency in treated irons. A double addition (iron

  7. High quality mask storage in an advanced Logic-Fab

    Science.gov (United States)

    Jähnert, Carmen; Fritsche, Silvio

    2012-02-01

    High efficient mask logistics as well as safe and high quality mask storage are essential requirements within an advanced lithography area of a modern logic waferfab. Fast operational availability of the required masks at the exposure tool with excellent mask condition requires a safe mask handling, safeguarding of high mask quality over the whole mask usage time without any quality degradation and an intelligent mask logistics. One big challenge is the prevention of haze on high advanced phase shift masks used in a high volume production line for some thousands of 248nm or 193nm exposures. In 2008 Infineon Dresden qualified a customer specific developed semi-bare mask storage system from DMSDynamic Micro Systems in combination with a high advanced mask handling and an interconnected complex logistic system. This high-capacity mask storage system DMS M1900.22 for more than 3000 masks with fully automated mask and box handling as well as full-blown XCDA purge has been developed and adapted to the Infineon Lithotoollandscape using Nikon and SMIF reticle cases. Advanced features for ESD safety and mask security, mask tracking via RFID and interactions with the exposure tools were developed and implemented. The stocker is remote controlled by the iCADA-RSM system, ordering of the requested mask directly from the affected exposure tool allows fast access. This paper discusses the advantages and challenges for this approach as well as the practical experience gained during the implementation of the new system which improves the fab performance with respect to mask quality, security and throughput. Especially the realization of an extremely low and stable humidity level in addition with a well controlled air flow at each mask surface, preventing masks from haze degradation and particle contamination, turns out to be a notable technical achievement. The longterm stability of haze critical masks has been improved significantly. Relevant environmental parameters like

  8. Significance of preoperative planning software for puncture and channel establishment in percutaneous endoscopic lumbar DISCECTOMY: A study of 40 cases.

    Science.gov (United States)

    Hu, Zhouyang; Li, Xinhua; Cui, Jian; He, Xiaobo; Li, Cong; Han, Yingchao; Pan, Jie; Yang, Mingjie; Tan, Jun; Li, Lijun

    2017-05-01

    Preoperative planning software has been widely used in many other minimally invasive surgeries, but there is a lack of information describing the clinical benefits of existing software applied in percutaneous endoscopic lumbar discectomy (PELD). This study aimed to compare the clinical efficacy of preoperative planning software in puncture and channel establishment of PELD with routine methods in treating lumbar disc herniation (LDH). From June 2016 to October 2016, 40 patients who had single L4/5 or L5/S1 disc herniation were divided into two groups. Group A adopted planning software for preoperative puncture simulation while Group B took routine cases discussion for making puncture plans. The channel establishment time, operative time, fluoroscopic times and complications were compared between the two groups. The surgical efficacy was evaluated according to the Visual Analogue Scale (VAS), Oswestry Disability Index (ODI) and modified Macnab's criteria. The mean channel establishment time was 25.1 ± 4.2 min and 34.6 ± 5.4 min in Group A and B, respectively (P  0.05). The findings of modified Macnab's criteria at each follow-up also showed no significant differences (P > 0.05). The application of preoperative planning software in puncture and cannula insertion planning in PELD was easy and reliable, and could reduce the channel establishment time, operative time and fluoroscopic times of PELD significantly. Copyright © 2017 IJS Publishing Group Ltd. Published by Elsevier Ltd. All rights reserved.

  9. S-shape relationship between customer satisfaction and willingness to pay premium prices for high quality cured pork products in Spain.

    Science.gov (United States)

    Cotes-Torres, Alejandro; Muñoz-Gallego, Pablo A; Cotes-Torres, José Miguel

    2012-03-01

    This paper explores 2 different probabilistic models explaining willingness to pay premium prices for high-quality cured products from the swine industry. Seven cured pork products (sausage, fuet, ham, loin, shoulder, salami and pepperoni) were studied in 9 food-stores in Valladolid, Spain. Consumers of the products were interviewed (686 completed surveys). It was found by using mixed effect statistical models that the relationship between willingness to pay a premium price and customer satisfaction had nonlinear behavior, following an S-shape with inverted slope which was the first empirical evidence of this type of behavior in meat products in real market conditions. It was also established that the interaction between satisfaction and current expenditure on the product was significant and indispensable for explaining consumers' willingness to pay premium price for cured pork products. Copyright © 2011 Elsevier Ltd. All rights reserved.

  10. Methylation analysis of CMTM3 and DUSP1 gene promoters in high-quality brush hair in the Yangtze River delta white goat.

    Science.gov (United States)

    Qiang, Wang; Guo, Haiyan; Li, Yongjun; Shi, Jianfei; Yin, Xiuyuan; Qu, Jingwen

    2018-08-20

    The Yangtze River delta white goat is the only goat breed that produces high-quality brush hair, which is specifically used in top-grade writing brushes. Previous studies have indicated that the CMTM3 and DUSP1 genes are involved in the growth and cycle of high-quality brush hair, and these genes are thought to be involved in the formation of high-quality brush hair traits. In this study, we investigated the relationship between methylation of CMTM3 and DUSP1 and such traits. The results indicated that the relative expression levels of the CMTM3 and DUSP1 genes were higher in non-high-quality brush hair than in high-quality brush hair. Furthermore, the CpG sites of the DUSP1 gene were not methylated, and the methylation level of CMTM3 was negatively correlated with the gene expression level. We believe that the DUSP1 gene regulates the formation of high-quality brush hair by non-methylated, and that methylation of the CMTM3 gene results in a decrease in its expression, causing an increase in the activity of the androgen receptor and the level of androgen. This high androgen level promotes the growth of high-quality brush hair. These study results provide a theoretical basis for further elucidating the molecular mechanism of the formation of high-quality brush hair characteristics, and provide scientific reference for the molecular breeding of high-quality brush hair. Copyright © 2018 Elsevier B.V. All rights reserved.

  11. Catalytic pyrolysis of microalgae to high-quality liquid bio-fuels

    International Nuclear Information System (INIS)

    Babich, I.V.; Hulst, M. van der; Lefferts, L.; Moulijn, J.A.; O'Connor, P.; Seshan, K.

    2011-01-01

    The pyrolytic conversion of chlorella algae to liquid fuel precursor in presence of a catalyst (Na 2 CO 3 ) has been studied. Thermal decomposition studies of the algae samples were performed using TGA coupled with MS. Liquid oil samples were collected from pyrolysis experiments in a fixed-bed reactor and characterized for water content and heating value. The oil composition was analyzed by GC-MS. Pretreatment of chlorella with Na 2 CO 3 influences the primary conversion of chlorella by shifting the decomposition temperature to a lower value. In the presence of Na 2 CO 3 , gas yield increased and liquid yield decreased when compared with non-catalytic pyrolysis at the same temperatures. However, pyrolysis oil from catalytic runs carries higher heating value and lower acidity. Lower content of acids in the bio-oil, higher aromatics, combined with higher heating value show promise for production of high-quality bio-oil from algae via catalytic pyrolysis, resulting in energy recovery in bio-oil of 40%. -- Highlights: → The pyrolytic catalytic conversion of chlorella algae to liquid fuel precursor. → Na 2 CO 3 as a catalyst for the primary conversion of chlorella. → Pyrolysis oil from catalytic runs carries higher heating value and lower acidity. → High-quality bio-oil from algae via catalytic pyrolysis with energy recovery in bio-oil of 40%.

  12. Frequency of chromosomal aneuploidy in high quality embryos from young couples using preimplantation genetic screening

    Directory of Open Access Journals (Sweden)

    Farzaneh Fesahat

    2017-09-01

    Full Text Available Background: Selection of the best embryo for transfer is very important in assisted reproductive technology (ART. Using morphological assessment for this selection demonstrated that the correlation between embryo morphology and implantation potential is relatively weak. On the other hand, aneuploidy is a key genetic factor that can influence human reproductive success in ART. Objective: The aim of this lab trial study was to evaluate the incidence of aneuploidies in five chromosomes in the morphologically high-quality embryos from young patients undergoing ART for sex selection. Materials and Methods: A total of 97 high quality embryos from 23 women at the age of 37or younger years that had previously undergone preimplantation genetic screening for sex selection were included in this study. After washing, the slides of blastomeres from embryos of patients were reanalyzed by fluorescence in-situ hybridization for chromosomes 13, 18 and 21. Results: There was a significant rate of aneuploidy determination in the embryos using preimplantation genetic screening for both sex and three evaluated autosomal chromosomes compared to preimplantation genetic screening for only sex chromosomes (62.9% vs. 24.7%, p=0.000. The most frequent detected chromosomal aneuploidy was trisomy or monosomy of chromosome 13. Conclusion: There is considerable numbers of chromosomal abnormalities in embryos generated in vitro which cause in vitro fertilization failure and it seems that morphological characterization of embryos is not a suitable method for choosing the embryos without these abnormalities

  13. Key elements of high-quality practice organisation in primary health care: a systematic review.

    Science.gov (United States)

    Crossland, Lisa; Janamian, Tina; Jackson, Claire L

    2014-08-04

    To identify elements that are integral to high-quality practice and determine considerations relating to high-quality practice organisation in primary care. A narrative systematic review of published and grey literature. Electronic databases (PubMed, CINAHL, the Cochrane Library, Embase, Emerald Insight, PsycInfo, the Primary Health Care Research and Information Service website, Google Scholar) were searched in November 2013 and used to identify articles published in English from 2002 to 2013. Reference lists of included articles were searched for relevant unpublished articles and reports. Data were configured at the study level to allow for the inclusion of findings from a broad range of study types. Ten elements were most often included in the existing organisational assessment tools. A further three elements were identified from an inductive thematic analysis of descriptive articles, and were noted as important considerations in effective quality improvement in primary care settings. Although there are some validated tools available to primary care that identify and build quality, most are single-strategy approaches developed outside health care settings. There are currently no validated organisational improvement tools, designed specifically for primary health care, which combine all elements of practice improvement and whose use does not require extensive external facilitation.

  14. Establishing a culturally specific nursing home for Finnish-speaking older persons in Sweden: A case study.

    Science.gov (United States)

    Hadziabdic, Emina; Hjelm, Katarina

    2018-04-01

    The study aims to describe the establishment of a culturally specific nursing home for Finnish-speaking older persons in Sweden. A descriptive qualitative study. A descriptive case study based on a review of 14 public documents and individual interviews with two experts in the area, analysed with qualitative content analysis. This study found that shared language, preservation of customs and habits and collaboration between the representatives of the municipality, Finnish-speaking migrant associations and staff at the nursing home influenced the development of the culturally specific nursing home for older Finnish-speaking people intended to avoid loneliness, isolation and misunderstandings among older Finnish-speaking. Collaboration between healthcare service for older persons and minority people resulted in an optimal culturally specific nursing home, simultaneously encountering the majority culture. Nursing and healthcare services need to be aware of positive effects of collaboration with stakeholders to achieve optimal culturally specific nursing homes.

  15. Fathers' experience of childbirth when non-progressive labour occurs and augmentation is established. A qualitative study

    DEFF Research Database (Denmark)

    Hasman, Kirsten; Kjaergaard, Hanne; Esbensen, Bente Appel

    2014-01-01

    as uncontrollable processes and (3) Relief about the decision of augmentation. The fathers had a rational approach and felt powerless when the process of labour was uncontrollable. They felt they were not able to help their partners in pain when non-progressive labour occurred. They experienced relief when......OBJECTIVE: Augmentation with oxytocin during labour has increased in Western obstetrics over the last few decades. The aim of this study was to describe how fathers experienced childbirth when non-progressive labour occurred and augmentation was established. METHOD: A qualitative descriptive design...... after experiencing the non-progressive labour, need directions from the midwives to carry out appropriate and usefull tasks....

  16. Establishment of a Zebrafish Infection Model for the Study of Wild-Type and Recombinant European Sheatfish Virus.

    Science.gov (United States)

    Martín, Verónica; Mavian, Carla; López Bueno, Alberto; de Molina, Antonio; Díaz, Eduardo; Andrés, Germán; Alcami, Antonio; Alejo, Alí

    2015-10-01

    Amphibian-like ranaviruses include pathogens of fish, amphibians, and reptiles that have recently evolved from a fish-infecting ancestor. The molecular determinants of host range and virulence in this group are largely unknown, and currently fish infection models are lacking. We show that European sheatfish virus (ESV) can productively infect zebrafish, causing a lethal pathology, and describe a method for the generation of recombinant ESV, establishing a useful model for the study of fish ranavirus infections. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

  17. Developmental validation of a Nextera XT mitogenome Illumina MiSeq sequencing method for high-quality samples.

    Science.gov (United States)

    Peck, Michelle A; Sturk-Andreaggi, Kimberly; Thomas, Jacqueline T; Oliver, Robert S; Barritt-Ross, Suzanne; Marshall, Charla

    2018-05-01

    Generating mitochondrial genome (mitogenome) data from reference samples in a rapid and efficient manner is critical to harnessing the greater power of discrimination of the entire mitochondrial DNA (mtDNA) marker. The method of long-range target enrichment, Nextera XT library preparation, and Illumina sequencing on the MiSeq is a well-established technique for generating mitogenome data from high-quality samples. To this end, a validation was conducted for this mitogenome method processing up to 24 samples simultaneously along with analysis in the CLC Genomics Workbench and utilizing the AQME (AFDIL-QIAGEN mtDNA Expert) tool to generate forensic profiles. This validation followed the Federal Bureau of Investigation's Quality Assurance Standards (QAS) for forensic DNA testing laboratories and the Scientific Working Group on DNA Analysis Methods (SWGDAM) validation guidelines. The evaluation of control DNA, non-probative samples, blank controls, mixtures, and nonhuman samples demonstrated the validity of this method. Specifically, the sensitivity was established at ≥25 pg of nuclear DNA input for accurate mitogenome profile generation. Unreproducible low-level variants were observed in samples with low amplicon yields. Further, variant quality was shown to be a useful metric for identifying sequencing error and crosstalk. Success of this method was demonstrated with a variety of reference sample substrates and extract types. These studies further demonstrate the advantages of using NGS techniques by highlighting the quantitative nature of heteroplasmy detection. The results presented herein from more than 175 samples processed in ten sequencing runs, show this mitogenome sequencing method and analysis strategy to be valid for the generation of reference data. Copyright © 2018 Elsevier B.V. All rights reserved.

  18. Possible causes of variation in acrylamide concentration in French fries prepared in food service establishments: an observational study.

    Science.gov (United States)

    Sanny, M; Jinap, S; Bakker, E J; van Boekel, M A J S; Luning, P A

    2012-05-01

    Acrylamide is a probable human carcinogen, and its presence in a range of fried and oven-cooked foods has raised considerable health concern world-wide. Dietary intake studies observed significant variations in acrylamide concentrations, which complicate risk assessment and the establishment of effective control measures. The objective of this study was to obtain an insight into the actual variation in acrylamide concentrations in French fries prepared under typical conditions in a food service establishment (FSE). Besides acrylamide, frying time, frying temperature, and reducing sugars were measured and the actual practices at receiving, thawing and frying during French fries preparation were observed and recorded. The variation in the actual frying temperature contributed most to the variation in acrylamide concentrations, followed by the variation in actual frying time; no obvious effect of reducing sugars was found. The lack of standardised control of frying temperature and frying time (due to inadequate frying equipment) and the variable practices of food handlers seem to contribute most to the large variation and high acrylamide concentrations in French fries prepared in a restaurant type of FSE as compared to chain fast-food services, and institutional caterers. The obtained insights in this study can be used to develop dedicated control measures in FSE, which may contribute to a sustainable reduction in the acrylamide intake. Copyright © 2011 Elsevier Ltd. All rights reserved.

  19. Establishing porcine monocyte-derived macrophage and dendritic cell systems for studying the interaction with PRRSV-1

    Directory of Open Access Journals (Sweden)

    Helen eSingleton

    2016-06-01

    Full Text Available Monocyte-derived macrophages (MoMØ and monocyte-derived dendritic cells (MoDC are two model systems well established in human and rodent systems that can be used to study the interaction of pathogens with host cells. Porcine reproductive and respiratory syndrome virus (PRRSV is known to infect myeloid cells, such as macrophages (MØ and dendritic cells (DC. Therefore, this study aimed to establish systems for the differentiation and characterization of MoMØ and MoDC for subsequent infection with PRRSV-1. M-CSF differentiated monocyte-derived macrophages (MoMØ were stimulated with activators for classical (M1 or alternative (M2 activation. GM-CSF and IL-4 generated monocyte-derived dendritic cells (MoDC were activated with the well established maturation cocktail containing PAMPs and cytokines. In addition, MoMØ and MoDC were treated with dexamethasone and IL-10, which are known immuno-suppressive reagents. Cells were characterized by morphology, phenotype and function and porcine MØ subsets highlighted some divergence from described human counterparts, while MoDC, appeared more similar to mouse and human DCs. The infection with PRRSV-1 strain Lena demonstrated different replication kinetics between MoMØ and MoDC and within subsets of each cell type. While MoMØ susceptibility was significantly increased by dexamethasone and IL-10 with an accompanying increase in CD163/CD169 expression, MoDC supported only a minimal replication of PRRSV These findings underline the high variability in the susceptibility of porcine myeloid cells towards PRRSV-1 infection.

  20. Manufacturing High-Quality Carbon Nanotubes at Lower Cost

    Science.gov (United States)

    Benavides, Jeanette M.; Lidecker, Henning

    2004-01-01

    A modified electric-arc welding process has been developed for manufacturing high-quality batches of carbon nanotubes at relatively low cost. Unlike in some other processes for making carbon nanotubes, metal catalysts are not used and, consequently, it is not necessary to perform extensive cleaning and purification. Also, unlike some other processes, this process is carried out at atmospheric pressure under a hood instead of in a closed, pressurized chamber; as a result, the present process can be implemented more easily. Although the present welding-based process includes an electric arc, it differs from a prior electric-arc nanotube-production process. The welding equipment used in this process includes an AC/DC welding power source with an integral helium-gas delivery system and circulating water for cooling an assembly that holds one of the welding electrodes (in this case, the anode). The cathode is a hollow carbon (optionally, graphite) rod having an outside diameter of 2 in. (approximately equal to 5.1 cm) and an inside diameter of 5/8 in. (approximately equal to 1.6 cm). The cathode is partly immersed in a water bath, such that it protrudes about 2 in. (about 5.1 cm) above the surface of the water. The bottom end of the cathode is held underwater by a clamp, to which is connected the grounding cable of the welding power source. The anode is a carbon rod 1/8 in. (approximately equal to 0.3 cm) in diameter. The assembly that holds the anode includes a thumbknob- driven mechanism for controlling the height of the anode. A small hood is placed over the anode to direct a flow of helium downward from the anode to the cathode during the welding process. A bell-shaped exhaust hood collects the helium and other gases from the process. During the process, as the anode is consumed, the height of the anode is adjusted to maintain an anode-to-cathode gap of 1 mm. The arc-welding process is continued until the upper end of the anode has been lowered to a specified height

  1. Angle-resolved reflection spectroscopy of high-quality PMMA opal crystal

    Science.gov (United States)

    Nemtsev, Ivan V.; Tambasov, Igor A.; Ivanenko, Alexander A.; Zyryanov, Victor Ya.

    2018-02-01

    PMMA opal crystal was prepared by a simple hybrid method, which includes sedimentation, meniscus formation and evaporation. We investigated three surfaces of this crystal by angle-resolved reflective light spectroscopy and SEM study. The angle-resolved reflective measurements were carried out in the 400-1100 nm range. We have determined the high-quality ordered surface of the crystal region. Narrow particle size distribution of the surface has been revealed. The average particle diameter obtained with SEM was nearly 361 nm. The most interesting result was that reflectivity of the surface turned out up to 98% at normal light incidence. Using a fit of dependences of the maximum reflectivity wavelength from an angle based on the Bragg-Snell law, the wavelength of maximum 0° reflectivity, the particle diameter and the fill factor have been determined. For the best surface maximum reflectivity wavelength of a 0° angle was estimated to be 869 nm. The particle diameter and fill factor were calculated as 372 nm and 0.8715, respectively. The diameter obtained by fitting is in excellent agreement with the particle diameter obtained with SEM. The reflectivity maximum is assumed to increase significantly when increasing the fill factor. We believe that using our simple approach to manufacture PMMA opal crystals will significantly increase the fabrication of high-quality photonic crystal templates and thin films.

  2. Comparison of reduced sugar high quality chocolates sweetened with stevioside and crude stevia 'green' extract.

    Science.gov (United States)

    Torri, Luisa; Frati, Alessandra; Ninfali, Paolino; Mantegna, Stefano; Cravotto, Giancarlo; Morini, Gabriella

    2017-06-01

    The demand for zero and reduced-sugar food products containing cocoa is expanding continuously. The present study was designed to evaluate the feasibility of producing high-quality chocolate sweetened with a crude extract of Stevia rebaudiana (Bertoni) prepared by a green microwave-assisted water-steam extraction procedure. Seven approximately isosweet chocolate formulations were developed, mixing cocoa paste, sucrose, commercial stevioside, crude green extract and maltitol in different proportions. All samples were analyzed for the determination of polyphenol and flavonoid content, antioxidant activity, and sensory acceptability. The use of a crude stevia extract allowed low-sugar, high-quality chocolates to be obtained that were also acceptable by consumers and had a significant increased antioxidant activity. Moreover, consumers' segmentation revealed a cluster of consumers showing the same overall liking for the sample with 50% sucrose replaced by the stevia crude extract as that obtained with the commercial stevioside and the control sample (without sucrose replacement). The results provide information that can contribute to promoting the development of sweet food products, with advantages in terms of an improved nutritional value (reduced sugar content and increased antioxidant activity) and a reduced impact of the production process on the environment. © 2016 Society of Chemical Industry. © 2016 Society of Chemical Industry.

  3. Effect of osmotic dehydration and vacuum-frying parameters to produce high-quality mango chips.

    Science.gov (United States)

    Nunes, Yolanda; Moreira, Rosana G

    2009-09-01

    Mango (Mangifera indica L.) is a fruit rich in flavor and nutritional values, which is an excellent candidate for producing chips. The objective of this study was to develop high-quality mango chips using vacuum frying. Mango ("Tommy Atkins") slices were pretreated with different maltodextrin concentrations (40, 50, and 65, w/v), osmotic dehydration times (45, 60, and 70 min), and solution temperatures (22 and 40 degrees C). Pretreated slices were vacuum fried at 120, 130, and 138 degrees C and product quality attributes (oil content, texture, color, carotenoid content) determined. The effect of frying temperatures at optimum osmotic dehydration times (65 [w/v] at 40 degrees C) was assessed. All samples were acceptable (scores > 5) to consumer panelists. The best mango chips were those pretreated with 65 (w/v) concentration for 60 min and vacuum fried at 120 degrees C. Mango chips under atmospheric frying had less carotenoid retention (32%) than those under vacuum frying (up to 65%). These results may help further optimize vacuum-frying processing of high-quality fruit-based snacks.

  4. Microbiological variation amongst fresh and minimally processed vegetables from retail establishers - a public health study in Pakistan

    Directory of Open Access Journals (Sweden)

    Sair, A.T.

    2017-07-01

    Full Text Available Fresh and minimally processed ready to eat vegetables are very attractive eatables amongst consumers as convenient, healthy and readily available foods, especially in the South Asian states. They provide numerous nutrients, phytochemicals, and vitamins but also harbor extensive quantity of potentially pathogenic bacteria. The aim of this study was to determine microbiological variation amongst fresh vegetables that were commercially available to the public at numerous retail establishments in Pakistan in order to present an overview of the quality of fresh produce. A total of 133 samples, collected from local distributors and retailers were tested for aerobic mesophilic and psychrotrophic, coliform and yeast and mould counts. Standard plating techniques were used to analyze all samples. Mesophilic count ranged from 3.1 to 10.3 log CFU/g with lowest and highest counts observed in onions and fresh cut vegetables. Psychrotrophic microorganisms count was as high as mesophilic microorganisms. Maximum counts for coliform were found in fresh cut vegetables with 100% samples falling over 6 log CFU/g. These results were consistent with yeast and moulds as well. In our study, Escherichia coli was determined as an indicator organism for 133 samples of fresh and minimally processed vegetables. Fresh cut vegetables showed the highest incidence of presumptive E. coli (69.9%. The results showed a poor quality of fresh vegetables in Pakistan and point to the implementation of good hygiene practices and food safety awareness amongst local distributors, food handlers at retail establishments.

  5. Basic Study of Establishment of Quality Assurance Processes to Develop an Integrated Quality Assurance System for Nuclear Power Plant Construction

    International Nuclear Information System (INIS)

    Lim, Byungki; Moon, Byeongsuk; Lee, Jae Kyoung

    2014-01-01

    An integrated quality assurance system has necessitated carrying out quality assurance programs in a systematic manner because the opportunities to expand business in overseas markets have increased since the export of a nuclear power plant to UAE in 2009. In this study, we use PDCA method to systematically analyze the quality assurance procedures that were used in previous projects for constructing nuclear power plants. We reached a classification system of quality assurance processes at each phase of nuclear power plant construction by integrating similar work related to quality such as planning, design, equipment manufacturing, construction and start-up. We also established a hierarchy of quality assurance processes to develop an integrated quality assurance system as a technology goal to be developed later. To obtain most updated quality assurance activities, a quality assurance process is structured by integrating similar works analyzed from quality assurance procedures through PDCA cycle method. At the implementation phase of Hierarchy of quality processes and sequence of processes for constructing nuclear power plant are established in this study. Integrated quality assurance system is to be developed by connecting organizations as well as stakeholders such as owners, Architect engineering, suppliers, contractors, and sub-contractors to carry out assigned work efficiently

  6. Opportunities and Challenges in Establishing a Cohort Study: An Example From Cleft Lip/Palate Research in the United Kingdom.

    Science.gov (United States)

    Stock, Nicola Marie; Humphries, Kerry; Pourcain, Beate St; Bailey, Maggie; Persson, Martin; Ho, Karen M; Ring, Susan; Marsh, Cathy; Albery, Liz; Rumsey, Nichola; Sandy, Jonathan

    2016-05-01

    Cleft lip and/or palate (CL/P) is one of the most common birth conditions in the world, but little is known about its causes. Professional opinion remains divided as to which treatments may be the most beneficial for patients with CL/P, and the factors that contribute to psychological adjustment are poorly understood. The use of different methodological approaches and tools plays a key role in hampering efforts to address discrepancies within the evidence base. A new UK-wide program of research, The Cleft Collective, was established to combat many of these methodological challenges and to address some of the key research questions important to all CL/P stakeholders. To describe the establishment of CL/P cohort studies in the United Kingdom and to consider the many opportunities this resource will generate. To date, protocols have been developed and implemented within most UK cleft teams. Biological samples, environmental information, and data pertaining to parental psychological well-being and child development are being collected successfully. Recruitment is currently on track to meet the ambitious target of approximately 9800 individuals from just more than 3000 families. The Cleft Collective cohort studies represent a significant step forward for research in the field of CL/P. The data collected will form a comprehensive resource of information about individuals with CL/P and their families. This resource will provide the basis for many future projects and collaborations, both in the United Kingdom and around the world.

  7. Basic Study of Establishment of Quality Assurance Processes to Develop an Integrated Quality Assurance System for Nuclear Power Plant Construction

    Energy Technology Data Exchange (ETDEWEB)

    Lim, Byungki; Moon, Byeongsuk; Lee, Jae Kyoung [Korea Hydro and Nuclear Power Co. Ltd., Daejeon (Korea, Republic of)

    2014-05-15

    An integrated quality assurance system has necessitated carrying out quality assurance programs in a systematic manner because the opportunities to expand business in overseas markets have increased since the export of a nuclear power plant to UAE in 2009. In this study, we use PDCA method to systematically analyze the quality assurance procedures that were used in previous projects for constructing nuclear power plants. We reached a classification system of quality assurance processes at each phase of nuclear power plant construction by integrating similar work related to quality such as planning, design, equipment manufacturing, construction and start-up. We also established a hierarchy of quality assurance processes to develop an integrated quality assurance system as a technology goal to be developed later. To obtain most updated quality assurance activities, a quality assurance process is structured by integrating similar works analyzed from quality assurance procedures through PDCA cycle method. At the implementation phase of Hierarchy of quality processes and sequence of processes for constructing nuclear power plant are established in this study. Integrated quality assurance system is to be developed by connecting organizations as well as stakeholders such as owners, Architect engineering, suppliers, contractors, and sub-contractors to carry out assigned work efficiently.

  8. Cuban typical doses for 99mTc-DMSA renal gammagraphy studies: a methodology for the establishment of reference levels

    International Nuclear Information System (INIS)

    Diaz Barreto, M.; Varela Corona, C.; Lopez Bejerano, G.M.; Perea Diaz, M.; Paz Viera, J.E.

    2008-01-01

    Since a handful of years ago, international rules on Radiological Protection include the principle of optimization of given dose to patients, if this procedure doesn't lessen diagnosis quality, and the establishment of reference levels of activity. For these reasons, the Radiological Protection staff of Cuban Institute of Nephrology's Nuclear Medicine Service, where morpho functional renal studies are carried out, 70% on infants and young children, started a research on that way. Thus, because their biggest incidence, 99m Tc -DMSA renal gammagraphy studies were chosen, using a General Electric 400 AT Planar Gamma Camera. Studied sample was randomly selected, including adults (12 peoples) and children (23); divided into 4 groups, lessen given dose step by step. Other items were kept in mind in the research, such age, weight, time delayed between administrations and image getting, getting time of each view and total time of the study, as well as radiopharmaceuticals quality and Gamma Camera performance. Image quality was evaluated for each case, using both, objective and subjective criteria. Objective evaluation was done by using contrast/noise ratios and variance of the random noise. They were used to develop clustering and discriminant analysis over the independent variables to detect groups with differentiated image quality from the physical and mathematical point of view. Subjective evaluation was performed using the criteria of two expert observers who had no information about the activity levels used. They evaluated image quality separately, giving a good, regular or bad evaluation for each image. As a conclusion, we found that it is possible to reduce the given activities in 50% and thus, indirectly, to reduce doses for workers and for the public. Additionally, we propose a methodology for the establishment of reference levels for 99m Tc -DMSA renal gammagraphy studies in Cuba, both, for adults and paediatric patients. (author)

  9. Protocol: A simple phenol-based method for 96-well extraction of high quality RNA from Arabidopsis

    Directory of Open Access Journals (Sweden)

    Coustham Vincent

    2011-03-01

    Full Text Available Abstract Background Many experiments in modern plant molecular biology require the processing of large numbers of samples for a variety of applications from mutant screens to the analysis of natural variants. A severe bottleneck to many such analyses is the acquisition of good yields of high quality RNA suitable for use in sensitive downstream applications such as real time quantitative reverse-transcription-polymerase chain reaction (real time qRT-PCR. Although several commercial kits are available for high-throughput RNA extraction in 96-well format, only one non-kit method has been described in the literature using the commercial reagent TRIZOL. Results We describe an unusual phenomenon when using TRIZOL reagent with young Arabidopsis seedlings. This prompted us to develop a high-throughput RNA extraction protocol (HTP96 adapted from a well established phenol:chloroform-LiCl method (P:C-L that is cheap, reliable and requires no specialist equipment. With this protocol 192 high quality RNA samples can be prepared in 96-well format in three hours (less than 1 minute per sample with less than 1% loss of samples. We demonstrate that the RNA derived from this protocol is of high quality and suitable for use in real time qRT-PCR assays. Conclusion The development of the HTP96 protocol has vastly increased our sample throughput, allowing us to fully exploit the large sample capacity of modern real time qRT-PCR thermocyclers, now commonplace in many labs, and develop an effective high-throughput gene expression platform. We propose that the HTP96 protocol will significantly benefit any plant scientist with the task of obtaining hundreds of high quality RNA extractions.

  10. Pilot social feasibility study for the establishment of a public human umbilical cord blood stem cell bank in South Africa.

    Science.gov (United States)

    Meissner-Roloff, Madelein; Young, Wendy; Rangaka, Isabella; Lombaard, Hennie; Dhai, Ames; Tsotsi, Norma; Pepper, Michael S

    2012-12-01

    There is a large unmet need in South Africa for bone marrow transplantation. Umbilical cord blood (UCB) is an important source of stem cells for the treatment of haematological and non-haematological diseases. Access to the two existing private umbilical cord blood stem cell banks (UCB SCBs) in South Africa is limited to individuals that can afford it, which further aggravates the ever increasing divide between families from different socio-economic classes. The problem is compounded by a severe global shortage of genetically compatible samples, representative of the South African demographics. Establishing a public human UCB SCB in South Africa would provide more South Africans with access to previously unavailable treatment in the form of affordable, genetically compatible stem cells for bone marrow transplantation. A public UCB SCB has many facets to consider, one of which is public preparedness and support for the bank. This was assessed in a social feasibility pilot study which is reported here. In addition to the findings of this social feasibility study, other important considerations for establishing a public human UCB SCB in SA include; (a) testing the samples for HIV and other infectious diseases (required for compliance with international regulatory standards); (b) flow cytometric analysis for enumeration of CD34+ UCB stem cells; (c) mapping of HLA genotypes/alleles; and (d) a study of the economic feasibility of this endeavour.The social feasibility study was conducted to gauge public preparedness and support for a public SCB through patient interviews and questionnaires. The process was dynamic due to its novel nature for interviewers and interviewees alike. Many obstacles were met and dealt with which lead to the compilation of results discussed here in the form of a pilot social feasibility study.In the South African context, we are faced with unique and rich challenges relating to cultural and religious differences that are further augmented by

  11. A study for the establishment of regulatory requirement and evaluation guide for station blackout in nuclear power plants

    International Nuclear Information System (INIS)

    Lim, J. H.; Koo, C. S.; Joo, W. P.; Oh, S. H.; Shin, W. K.

    1999-01-01

    The consequence of SBO event could be a severe accident unless AC power was restored within a proper time, because many safety systems depend upon AC power. Based on the severity, the SBO has been extensively studied since it was identified as Unresolved Safety Issue at USNRC. The resolution of those studies is a rule-making such as 10 CFR 50.63 and Regulatory Guide 1.155. But there is no regulatory requirements of SBO for an operating domestic nuclear power plant up to the present time. This tudy has established SBO rule(regulatory requirements and evaluation guides) for an operating PWR type of the operating nuclear power plants in Korea

  12. Establishment of 60Co dose calibration curve using fluorescent in situ hybridization assay technique: Result of preliminary study

    International Nuclear Information System (INIS)

    Rahimah Abdul Rahim; Noriah Jamal; Noraisyah Mohd Yusof; Juliana Mahamad Napiah; Nelly Bo Nai Lee

    2010-01-01

    This study aims at establishing an in-vitro 60 Co dose calibration curve using Fluorescent In-Situ Hybridization assay technique for the Malaysian National Bio dosimetry Laboratory. Blood samples collected from a female healthy donor were irradiated with several doses of 60 Co radiation. Following culturing of lymphocytes, microscopic slides are prepared, denatured and hybridized. The frequencies of translocation are estimated in the metaphases. A calibration curve was then generated using a regression technique. It shows a good fit to a linear-quadratic model. The results of this study might be useful in estimating absorbed dose for the individual exposed to ionizing radiation retrospectively. This information may be useful as a guide for medical treatment for the assessment of possible health consequences. (author)

  13. A high efficiency, high quality and low cost internal regulated bioanalytical laboratory to support drug development needs.

    Science.gov (United States)

    Song, Yan; Dhodda, Raj; Zhang, Jun; Sydor, Jens

    2014-05-01

    In the recent past, we have seen an increase in the outsourcing of bioanalysis in pharmaceutical companies in support of their drug development pipeline. This trend is largely driven by the effort to reduce internal cost, especially in support of late-stage pipeline assets where established bioanalytical assays are used to analyze a large volume of samples. This article will highlight our perspective of how bioanalytical laboratories within pharmaceutical companies can be developed into the best partner in the advancement of drug development pipelines with high-quality support at competitive cost.

  14. Establishment study of the in vivo imaging analysis with small animal imaging modalities for bio-durg development

    International Nuclear Information System (INIS)

    Jang, Beomsu; Park, Sanghyeon; Choi, Dae Seong; Park, Jeonghoon; Jung, Uhee; Lee, Yun Jong

    2012-01-01

    In this study, we established the image modalities (micro-PET, SPECT/CT) using the experimental animal (mouse) for the development of imaging assessment method for the bio-durg and extramural collaboration proposal. We examined the micro-SPECT/CT, PET imaging study using the Siemens Inveon micro-multimodality system (SPECT/CT) and imaging study using the Siemens Inveon micro-multimodality system (SPECT/CT) and micro-PET with 99m Tc tricarbonyl bifunctional chelators and 18 F-clotrimazole derivative. SPECT imaging studies were performed with 99m Tc tricarbonyl BFCs. PET imaging study was performed with 18 F-clotrimazole derivatives. We performed the PET image study of 18 F-clotrimazole derivatives using U87MG tumor bearing mice. Also we tested the intramural and extramural collaboration using small animal imaging modalities and prepared the draft of extramural R and D operation manual for small animal imaging modalities and the experimental animal imaging facility. These research results can be utilized as a basic image study protocols and data for the image assessment of drugs including biological drug

  15. A study of Ground Source Heat Pump based on a heat infiltrates coupling model established with FEFLOW

    Science.gov (United States)

    Chen, H.; Hu, C.; Chen, G.; Zhang, Q.

    2017-12-01

    Geothermal heat is a viable source of energy and its environmental impact in terms of CO2 emissions is significantly lower than conventional fossil fuels. it is vital that engineers acquire a proper understanding about the Ground Source Heat Pump (GSHP). In this study, the model of the borehole exchanger under conduction manners and heat infiltrates coupling manners was established with FEFLOW. The energy efficiency, heat transfer endurance and heat transfer in the unit depth were introduced to quantify the energy efficient and the endurance period. The performance of a the Borehole Exchanger (BHE) in soil with and without groundwater seepage was analyzed of heat transfer process between the soil and the working fluid. Basing on the model, the varied regularity of energy efficiency performance an heat transfer endurance with the conditions including the different configuration of the BHE, the soil properties, thermal load characteristic were discussed. Focus on the heat transfer process in multi-layer soil which one layer exist groundwater flow. And an investigation about thermal dispersivity was also analyzed its influence on heat transfer performance. The final result proves that the model of heat infiltrates coupling model established in this context is reasonable, which can be applied to engineering design.

  16. Establishment of a transgenic hairy root system in wild and domesticated watermelon (Citrullus lanatus) for studying root vigor under drought.

    Science.gov (United States)

    Kajikawa, Masataka; Morikawa, Kaoru; Abe, Yosuke; Yokota, Akiho; Akashi, Kinya

    2010-07-01

    Root vigor is an important trait for the growth of terrestrial plants, especially in water-deficit environments. Although deserts plants are known for their highly developed root architecture, the molecular mechanism responsible for this trait has not been determined. Here we established an efficient protocol for the genetic manipulation of two varieties of watermelon plants: a desert-grown wild watermelon that shows vigorous root growth under drought, and a domesticated cultivar showing retardation of root growth under drought stress. Agrobacterium rhizogenes-mediated transgenic hairy roots were efficiently induced and selected from the hypocotyls of these plants. Transgenic GUS expression was detected in the roots by RT-PCR and histochemical GUS staining. Moreover, a liquid culture system for evaluating their root growth was also established. Interestingly, growth of the hairy roots derived from domesticated variety of watermelon strongly inhibited under high osmotic condition, whereas the hairy roots derived from wild variety of watermelon retained substantial growth rates under the stress condition. The new protocol presented here offers a powerful tool for the comparative study of the molecular mechanism underlying drought-induced root growth in desert plants.

  17. European Pharmacopoeia biological reference preparation for poliomyelitis vaccine (inactivated): collaborative study for the establishment of batch No. 3.

    Science.gov (United States)

    Martin, J; Daas, A; Milne, C

    2016-01-01

    Inactivated poliomyelitis vaccines are an important part of the World Health Organization (WHO) control strategy to eradicate poliomyelitis. Requirements for the quality control of poliomyelitis vaccines (inactivated) include the use of an in vitro D antigen quantification assay for potency determination on the final lot as outlined in the European Pharmacopoeia (Ph. Eur.) monograph 0214. Performance of this assay requires a reference preparation calibrated in International Units (IU). A Ph. Eur. biological reference preparation (BRP) for poliomyelitis vaccine (inactivated) calibrated in IU has been established for this purpose. Due to the dwindling stocks of batch 2 of the BRP a collaborative study was run as part of the European Directorate for the Quality of Medicines & HealthCare (EDQM) Biological Standardisation Programme to establish BRP batch 3 (BRP3). Twelve laboratories including Official Medicines Control Laboratories (OMCLs) and manufacturers participated. The candidate BRP3 (cBRP3) was from the same source and had the same characteristics as BRP batch 2 (BRP2). During the study the candidate was calibrated against the 3 rd International Standard for inactivated poliomyelitis vaccine using in-house D antigen ELISA assays in line with the Ph. Eur. monograph 0214. The candidate was also compared to BRP2 to evaluate the continuity. Based on the results of the study, values of 320 DU/mL, 78 DU/mL and 288 DU/mL (D antigen units/mL) (IU) for poliovirus type 1, 2 and 3 respectively were assigned to the candidate. In June 2016, the Ph. Eur. Commission adopted the material as Ph. Eur. BRP for poliomyelitis vaccine (inactivated) batch 3.

  18. How to Establish and Follow up a Large Prospective Cohort Study in the 21st Century - Lessons from UK COSMOS

    Science.gov (United States)

    Toledano, Mireille B.; Smith, Rachel B.; Brook, James P.; Douglass, Margaret; Elliott, Paul

    2015-01-01

    Large-scale prospective cohort studies are invaluable in epidemiology, but they are increasingly difficult and costly to establish and follow-up. More efficient methods for recruitment, data collection and follow-up are essential if such studies are to remain feasible with limited public and research funds. Here, we discuss how these challenges were addressed in the UK COSMOS cohort study where fixed budget and limited time frame necessitated new approaches to consent and recruitment between 2009-2012. Web-based e-consent and data collection should be considered in large scale observational studies, as they offer a streamlined experience which benefits both participants and researchers and save costs. Commercial providers of register and marketing data, smartphones, apps, email, social media, and the internet offer innovative possibilities for identifying, recruiting and following up cohorts. Using examples from UK COSMOS, this article sets out the dos and don’ts for today's cohort studies and provides a guide on how best to take advantage of new technologies and innovative methods to simplify logistics and minimise costs. Thus a more streamlined experience to the benefit of both research participants and researchers becomes achievable. PMID:26147611

  19. Inequality in Preschool Quality? Community-Level Disparities in Access to High-Quality Learning Environments

    Science.gov (United States)

    Bassok, Daphna; Galdo, Eva

    2016-01-01

    In recent years, unequal access to high-quality preschool has emerged as a growing public policy concern. Because of data limitations, it is notoriously difficult to measure disparities in access to early learning opportunities across communities and particularly challenging to quantify gaps in access to "high-quality" programs. Research…

  20. Protoliths of enigmatic Archaean gneisses established from zircon inclusion studies: Case study of the Caozhuang quartzite, E. Hebei, China

    Directory of Open Access Journals (Sweden)

    Allen P. Nutman

    2014-07-01

    Full Text Available A diverse suite of Archaean gneisses at Huangbaiyu village in the North China Craton, includes rare fuchsite-bearing (Cr-muscovite siliceous rocks – known as the Caozhuang quartzite. The Caozhuang quartzite is strongly deformed and locally mylonitic, with silica penetration and pegmatite veining common. It contains abundant 3880–3600 Ma and some Palaeoarchaean zircons. Because of its siliceous nature, the presence of fuchsite and its complex zircon age distribution, it has until now been accepted as a (mature quartzite. However, the Caozhuang quartzite sample studied here is feldspathic. The shape and cathodoluminescence petrography of the Caozhuang quartzite zircons show they resemble those found in immature detrital sedimentary rocks of local provenance or in Eoarchaean polyphase orthogneisses, and not those in mature quartzites. The Caozhuang quartzite intra-zircon mineral inclusions are dominated by quartz, with lesser biotite, apatite (7% and alkali-feldspar, and most inclusions are morphologically simple. A Neoarchaean orthogneiss from near Huangbaiyu displays morphologically simple inclusions with much more apatite (73%, as is typical for fresh calc-alkaline granitoids elsewhere. Zircons were also examined from a mature conglomerate quartzite clast and an immature feldspathic sandstone of the overlying weakly metamorphosed Mesoproterozoic Changcheng System. These zircons have oscillatory zoning, showing they were sourced from igneous rocks. The quartzite clast zircons contain only rare apatite inclusions (<1%, with domains with apatite habit now occupied by intergrowths of muscovite + quartz ± Fe-oxides ± baddeleyite. We interpret that these were once voids after apatite inclusions that had dissolved during Mesoproterozoic weathering, which were then filled with clays ± silica and then weakly metamorphosed. Zircons in the immature feldspathic sandstone show a greater amount of preserved apatite (11%, but with petrographic

  1. Establishing a Methodology to Examine the Effects of War-Zone PTSD on the Family: The Family Foundations Study

    Science.gov (United States)

    Vasterling, Jennifer J.; Taft, Casey T.; Proctor, Susan P.; MacDonald, Helen Z.; Lawrence, Amy; Kalill, Kathleen; Kaiser, Anica P.; Lee, Lewina O.; King, Daniel W.; King, Lynda A.; Fairbank, John A.

    2015-01-01

    Military deployment may adversely affect not only returning veterans, but their families, as well. As a result, researchers have increasingly focused on identifying risk and protective factors for successful family adaptation to war-zone deployment, re-integration of the returning veteran, and the longer-term psychosocial consequences of deployment experienced by some veterans and families. Posttraumatic stress disorder (PTSD) among returning veterans may pose particular challenges to military and military veteran families; however, questions remain regarding the impact of the course of veteran PTSD and other potential moderating factors on family adaptation to military deployment. The Family Foundations Study builds upon an established longitudinal cohort of Army soldiers (i.e., the Neurocognition Deployment Health Study) to help address remaining knowledge gaps. This report describes the conceptual framework and key gaps in knowledge that guided the study design, methodological challenges and special considerations in conducting military family research, and how these gaps, challenges, and special considerations are addressed by the study. PMID:26077194

  2. The high quality of safety culture is absolutely necessary for the nuclear industry development

    International Nuclear Information System (INIS)

    Amiruddin, A.

    1998-01-01

    Batan as a facilitator in achieving the nuclear programme, has to start to introduce the nuclear science and technology to the publics and announces the nuclear activities results. By this mean time, most of people is still quite sure considering that the use of fossil fuel is better than that of nuclear fuel, even though there will be no other choice ultimately to use nuclear energy. This contradiction appears due to three reasons i.e., public's unbelieveness crisis dealt with less of knowledge of public about nuclear sciences and technology, their confident of nuclear-danger risks and the broadly miss-information sprout by the opposition. The main challenge created from the crisis of the safety culture of human activities. Some points to anticipated those situation are to establish infrastructure, maintain co-operation, links and coordination within points in the infrastructure, also to create the working culture system based on professional development and high quality safety management, and to increase publics information by a birds point approach through regional, cultural, social and political communication. Publics knowledge and understanding will bring about their supports and acceptances to the nuclear programme and its development (Nuclear Power Plant as a particular)

  3. Enabling information sharing by establishing trust in supply chains: A case study in the South African automotive industry

    Directory of Open Access Journals (Sweden)

    Roxanne Piderit

    2011-10-01

    Objectives: This paper explored the relationship between trust and information sharing in South African automotive supply chains, and establishes the importance of nurturing a cyclical relationship between these two factors. In addition, the role of information technology (IT in supporting this relationship was considered. By improving both trust and information sharing, the performance and competitiveness of the supply chain can be improved. Method: An examination of the effects of a lack of trust in a supply chain relationship, and the consequential lack of information flow, was conducted by means of a case study of an Eastern Cape-based automotive supplier. A case study research method was followed for this study, which made use of multiple data collection methods, including document survey and participant observations. The case selected is an East London based subsidiary of a larger multinational automotive component supplier to both local and international automotive original equipment manufacturers. Results: The findings led to the conclusion that the way forward for competitive supply chains is to build trust in the supply chain in order to improve information flow, and vice versa. Information technology can be used to nurture this cyclical relationship between trust and information sharing. Conclusion: It is proposed that simultaneously improving information flow and trust in an interorganisational relationship leads to improved supply chain performance and competitiveness.

  4. [On establishing comparative reference system for syndrome classification study from the thinking characteristics of syndrome differentiation dependent therapy].

    Science.gov (United States)

    Liu, Ping; Hu, Yi-yang; Ni, Li-qiang

    2006-05-01

    To create a comparative referential system for syndrome classification study by viewing from the thinking characteristics of TCM on syndrome differentiation dependent therapy (SDDT), through analyzing the thinking process of SDDT, and the basic features of disease, syndrome and prescription, combining the basic principles of modern evidence-based medicine and feasibility of establishing integrative disease-syndrome animal model. The practice of creating a comparative referential system based on clinical efficacy of prescription was discussed around syndrome pathogenesis and its relationship with disease and prescription, which was one of the important scientific problems in TCM syndrome study. The authors hold that, it may be one of the available approaches for the present study on integration of disease with syndrome by way of insisting on the thinking pathway of stressing the characteristics of TCM and intermerging with modern scientific design; on taking the efficacy of prescription as the comparative reference system to accumulate and improve unceasingly according to the TCM method of syndrome diagnosis inferred from effect of prescription with reverse thought (i.e., to differentiate syndrome from the effect of prescription), and thus build up the syndrome diagnostic standard on the solid clinical and scientific base.

  5. Instructional Technology Professional Development Evaluation: Developing a High Quality Model

    Science.gov (United States)

    Gaytan, Jorge A.; McEwen, Beryl C.

    2010-01-01

    Background: The literature contains very few studies that focused on evaluating the impact of professional development activities on student learning. And, many of these studies failed to determine whether the professional development activities met their primary goal--to improve the learning process. Purpose: The purpose of this study was to use…

  6. Achieving high-quality care: a view from NICE.

    Science.gov (United States)

    Leng, Gillian; Partridge, Gemma

    2018-01-01

    The National Institute for Health and Care Excellence (NICE) was established in 1999 to provide evidence-based guidance. The task of producing guidance by reviewing primary research data and using an advisory committee to develop evidence-based recommendations, is not straightforward. Guidance production is, however, less challenging than the task of putting evidence-based recommendations into practice.NICE is very sensitive to this challenge as, since 1999, over 1500 pieces of NICE guidance have been published. A number of pieces of guidance relate to heart disease, including pharmaceutical agents, new medical technologies and clinical guidelines. Examples include guidelines on acute heart failure and atrial fibrillation, and advice on technologies including edoxaban and implantable cardioverter defibrillators.The research evidence is clear that a change in practice rarely comes about as a result of simply disseminating guidance on best practice. Simple dissemination is particularly ineffective if the guidance has not been produced by a well-respected, credible organisation. It is also clear from the literature that implementation is more successful when more than one approach is taken, and when there is alignment between efforts at organisational, local and national levels.At an organisational level, there should be support from the Board for quality improvement, with ongoing measurement of progress. Resources should be provided for targeted change programmes, particularly where new guidance suggests improvements are required. A systematic process for putting change in place should include identifying barriers to change, agreeing interventions to overcome the barriers and drive forward improvement and planning for implementation and evaluation. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  7. Controlled synthesis of high-quality crystals of monolayer MoS2 for nanoelectronic device application

    DEFF Research Database (Denmark)

    Yang, Xiaonian; Li, Qiang; Hu, Guofeng

    2016-01-01

    . Monolayer MoS2 so far can be obtained by mechanical exfoliation or chemical vapor deposition (CVD). However, controllable synthesis of large area monolayer MoS2 with high quality needs to be improved and their growth mechanism requires more studies. Here we report a systematical study on controlled...... synthesis of high-quality monolayer MoS2 single crystals using low pressure CVD. Large-size monolayer MoS2 triangles with an edge length up to 405 mu m were successfully synthesized. The Raman and photoluminescence spectroscopy studies indicate high homogenous optical characteristic of the synthesized...... monolayer MoS2 triangles. The transmission electron microscopy results demonstrate that monolayer MoS2 triangles are single crystals. The back-gated field effect transistors (FETs) fabricated using the as-grown monolayer MoS2 show typical n-type semiconductor behaviors with carrier mobility up to 21.8 cm(2...

  8. A protocol for generating a high-quality genome-scale metabolic reconstruction.

    Science.gov (United States)

    Thiele, Ines; Palsson, Bernhard Ø

    2010-01-01

    Network reconstructions are a common denominator in systems biology. Bottom-up metabolic network reconstructions have been developed over the last 10 years. These reconstructions represent structured knowledge bases that abstract pertinent information on the biochemical transformations taking place within specific target organisms. The conversion of a reconstruction into a mathematical format facilitates a myriad of computational biological studies, including evaluation of network content, hypothesis testing and generation, analysis of phenotypic characteristics and metabolic engineering. To date, genome-scale metabolic reconstructions for more than 30 organisms have been published and this number is expected to increase rapidly. However, these reconstructions differ in quality and coverage that may minimize their predictive potential and use as knowledge bases. Here we present a comprehensive protocol describing each step necessary to build a high-quality genome-scale metabolic reconstruction, as well as the common trials and tribulations. Therefore, this protocol provides a helpful manual for all stages of the reconstruction process.

  9. Certifying leaders? high-quality management practices and healthy organisations: an ISO-9000 based standardisation approach.

    Science.gov (United States)

    Montano, Diego

    2016-08-05

    The present study proposes a set of quality requirements to management practices by taking into account the empirical evidence on their potential effects on health, the systemic nature of social organisations, and the current conceptualisations of management functions within the framework of comprehensive quality management systems. Systematic reviews and meta-analyses focusing on the associations between leadership and/or supervision and health in occupational settings are evaluated, and the core elements of an ISO 9001 standardisation approach are presented. Six major occupational health requirements to high-quality management practices are identified pertaining to communication processes, organisational justice, role clarity, decision making, social influence processes and management support. It is concluded that the quality of management practices may be improved by developing a quality management system of management practices that ensures not only conformity to product but also to occupational safety and health requirements. Further research may evaluate the practicability of the proposed approach.

  10. Clinico-pathological study to evaluate oral lichen planus for the establishment of clinical and histopathological diagnostic criteria.

    Science.gov (United States)

    Hiremath, Santhosh; Kale, Alka D; Hallikerimath, Seema

    2015-01-01

    Lichen planus and lichenoid lesions affecting the oral cavity show similar clinico-pathological features creating a diagnostic dilemma. Hence, the aim of the present study was to establish a clinical and histopathological correlation in the diagnosis of oral lichen planus, based on the modified WHO diagnostic criteria of oral lichen planus and oral lichenoid lesions proposed by Van der Meij and Van der Waal in 2003. In the present study, 100 cases of oral lichen planus were clinically and histopathologically analyzed. Out of the 100 cases, 50 were prospective and 50 were retrospective cases. Prospective cases were collected based on the clinical diagnosis of oral lichen planus and oral lichenoid lesion. Retrospective cases were collected based on the histopathological diagnosis of oral lichen planus. Both the clinical and histopathological analyses were performed based on a proposal for a set of modified diagnostic criteria of oral lichen planus and oral lichenoid lesion. A final diagnosis of oral lichen planus was made only after the correlation of the clinical diagnosis with the histopathological diagnosis. The interobserver agreement among three observers for both prospective and retrospective cases in the final diagnosis of oral lichen planus was found to be "good" to "very good" indicating high reproducibility. However, the final diagnoses of true oral lichen planus after clinico-pathological correlation in prospective and retrospective study groups appeared to be 38.0% and 54.0% respectively. The results of the present study revealed mild to moderate clinico-pathological correlation in the final diagnosis of oral lichen planus for the prospective and retrospective study groups respectively.

  11. Establishing ¹H nuclear magnetic resonance based metabonomics fingerprinting profile for spinal cord injury: a pilot study.

    Science.gov (United States)

    Jiang, Hua; Peng, Jin; Zhou, Zhi-yuan; Duan, Yu; Chen, Wei; Cai, Bin; Yang, Hao; Zhang, Wei

    2010-09-01

    Spinal cord injury (SCI) is a complex trauma that consists of multiple pathological mechanisms involving cytotoxic, oxidation stress and immune-endocrine. This study aimed to establish plasma metabonomics fingerprinting atlas for SCI using (1)H nuclear magnetic resonance (NMR) based metabonomics methodology and principal component analysis techniques. Nine Sprague-Dawley (SD) male rats were randomly divided into SCI, normal and sham-operation control groups. Plasma samples were collected for (1)H NMR spectroscopy 3 days after operation. The NMR data were analyzed using principal component analysis technique with Matlab software. Metabonomics analysis was able to distinguish the three groups (SCI, normal control, sham-operation). The fingerprinting atlas indicated that, compared with those without SCI, the SCI group demonstrated the following characteristics with regard to second principal component: it is made up of fatty acids, myc-inositol, arginine, very low-density lipoprotein (VLDL), low-density lipoprotein (LDL), triglyceride (TG), glucose, and 3-methyl-histamine. The data indicated that SCI results in several significant changes in plasma metabolism early on and that a metabonomics approach based on (1)H NMR spectroscopy can provide a metabolic profile comprising several metabolite classes and allow for relative quantification of such changes. The results also provided support for further development and application of metabonomics technologies for studying SCI and for the utilization of multivariate models for classifying the extent of trauma within an individual.

  12. Get your high-quality low-cost genome sequence

    NARCIS (Netherlands)

    Faino, L.; Thomma, B.P.H.J.

    2014-01-01

    The study of whole-genome sequences has become essential for almost all branches of biological research. Next-generation sequencing (NGS) has revolutionized the scalability, speed, and resolution of sequencing and brought genomic science within reach of academic laboratories that study non-model

  13. Control of Established Gingivitis and Dental Plaque Using a 1450 ppm Fluoride/Zinc-based Dentifrice: A Randomized Clinical Study.

    Science.gov (United States)

    Zhong, Y; Li, X; Hu, D Y; Mateo, L R; Morrison, B M; Delgado, E; Zhang, Y P

    2015-01-01

    To investigate the clinical efficacy in controlling established gingivitis and dental plaque of a 1450 ppm fluoride as sodium monofluorophosphate (SMFP)/zinc-based dentifrice, as compared to a zinc-free dentifrice with 1450 ppm fluoride as SMFP after six months product use. A six-month clinical study, with eighty-six (86) subjects, was conducted in Chengdu, China, using a double-blind, randomized, parallel-group treatment design. After a baseline evaluation, study subjects were randomly assigned to one of the two study treatments: 1) 1450 ppm fluoride as SMFP/zinc-based dentifrice (Test) or 2) 1450 ppm fluoride as SMFP/zinc-free dentifrice (Negative Control). Subjects were provided with a soft bristle toothbrush and brushed their teeth twice daily (morning and evening) for one minute with their assigned dentifrice. After three months, and again after six months of product use, subjects returned to the testing facility for their followup gingivitis and plaque examinations. Statistical analyses were performed separately for the gingivitis assessments and dental plaque assessments using the appropriate statistical methods. All statistical tests of hypotheses were two-sided, and employed a level of significance of α = 0.05. After three and six months of product use, subjects assigned to the Test treatment exhibited statistically significant (p gingival index and plaque index scores as compared to subjects assigned to the Negative Control treatment. The results of this single-center, double-blind, parallel-group and randomized clinical study support the conclusion that a 1450 ppm fluoride as SMFP/zinc-based dentifrice provides clinically meaningful and statistically significant reductions in gingivitis (23.8%) and dental plaque (22.5%) as compared to a 1450 ppm fluoride as SMFP/zinc-free dentifrice over a six-month period of twice-daily product use.

  14. High-quality single crystals for neutron experiments

    Indian Academy of Sciences (India)

    studies and our collaborative research projects with other UK and international groups will be discussed. Keywords. Crystal growth; floating zone method; neutron scattering. ... of single crystals of new materials is a highly competitive business.

  15. Overcoming job demands to deliver high quality care in a hospital setting across Europe: The role of teamwork and positivity

    OpenAIRE

    Montgomery Anthony; Panagopoulou Efharis; Costa Patricia

    2014-01-01

    Health care professionals deal on a daily basis with several job demands – emotional, cognitive, organizational and physical. They must also ensure high quality care to their patients. The aim of this study is to analyse the impact of job demands on quality of care and to investigate team (backup behaviors) and individual (positivity ratio) processes that help to shield that impact. Data was collected from 2,890 doctors and nurses in 9 European countries by means of questionnaires. Job demand...

  16. Establishment of a model of cochlear lesions in rats to study potential gene therapy for sensorineural hearing loss.

    Science.gov (United States)

    Wang, Ye; Qiao, Li; Chen, Yang; Wen, Liting; Yue, Bo; Qiu, Jianhua; Wu, Shengxi

    2015-12-01

    Sensorineural hearing loss seriously influences a patient's daily life, and no effective treatments exist to date. Gene therapy is a potential treatment for regenerating hair cells to restore hearing. In this study, we established a cochlear lesions model to study hair cell regeneration by co-administration of kanamycin and furosemide. After the injections, we assessed the survival of outer hair cells (OHC), inner hair cells (IHC), supporting cells (SC), spiral ganglion neurons (SGN) and peripheral axons. Moreover, we used two viral vectors to detect the transgene distribution. Our results showed at 12h post-treatment, numerous OHC were missing in the basal turn. At 24h post-treatment, all OHCs in basal half of the cochlea were lost, and by 48h, OHC loss had spread to the apical coil. Four days after the injections, all OHCs were absent. At 1mo post-treatment, the organ of Corti had collapsed. In contrast, most of the SC remained 4d after the injections. The loss of SGN and peripheral axons was consistent with this time course post-treatment. The results of transgene distribution suggested the correlative gene can be transferred into the organ of Corti using adenoviruses (AdV) vectors and lentiviruses (LV) vectors in our cochlear lesion model. We assessed the details of HC death at more time point and chosen the time point for gene transfer in this model. We conclude that this cochlear lesion model would be suitable for the study of hair cell regeneration. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  17. Establishing the reliability and validity of the Zagazig Depression Scale in a UK student population: an online pilot study

    Directory of Open Access Journals (Sweden)

    Challenor Emily C

    2010-12-01

    Full Text Available Abstract Background It is thought that depressive disorders will be the second leading cause of disability worldwide by 2020. Recently, there is a steady increase in the number of university students diagnosed and treated as depression patients. It can be assumed that depression is a serious mental health problem for university students because it affects all age groups of the students either younger or older equally. The current study aims to establish the reliability and validity of the Zagazig Depression scale in a UK sample. Methods The study was a cross-sectional online survey. A sample of 133 out of 275 undergraduate students from a range of UK Universities in the academic year 2008-2009, aged 20.3 ± 6.3 years old were recruited. A modified back translated version of Zagazig Depression scale was used. In order to validate the Zagazig Depression scale, participants were asked to complete the Patient Health Questionnaire. Statistical analysis includes Kappa analysis, Cronbach's alpha, Spearman's correlation analysis, and Confirmatory Factor analysis. Results Using the recommended cut-off of Zagazig Depression scale for possible minor depression it was found that 30.3% of the students have depression and higher percentage was identified according to the Patient Health Questionnaire (37.4%. Females were more depressed. The mean ZDS score was 8.3 ± 4.2. Rates of depression increase as students get older. The reliability of The ZDS was satisfactory (Cronbach's alpha was .894. For validity, ZDS score was strongly associated with PHQ, with no significant difference (p-value > 0.05, with strong positive correlation (r = +.8, p-value Conclusion The strong, significant correlation between the PHQ and ZDS, along with high internal consistency of the ZDS as a whole provides evidence that ZDS is a reliable measure of depressive symptoms and is promising for the use of the translated ZDS in a large-scale cross-culture study.

  18. Establishing the reliability and validity of the Zagazig Depression Scale in a UK student population: an online pilot study.

    Science.gov (United States)

    Ibrahim, Ahmed K; Kelly, Shona J; Challenor, Emily C; Glazebrook, Cris

    2010-12-10

    It is thought that depressive disorders will be the second leading cause of disability worldwide by 2020. Recently, there is a steady increase in the number of university students diagnosed and treated as depression patients. It can be assumed that depression is a serious mental health problem for university students because it affects all age groups of the students either younger or older equally. The current study aims to establish the reliability and validity of the Zagazig Depression scale in a UK sample. The study was a cross-sectional online survey. A sample of 133 out of 275 undergraduate students from a range of UK Universities in the academic year 2008-2009, aged 20.3 ± 6.3 years old were recruited. A modified back translated version of Zagazig Depression scale was used. In order to validate the Zagazig Depression scale, participants were asked to complete the Patient Health Questionnaire. Statistical analysis includes Kappa analysis, Cronbach's alpha, Spearman's correlation analysis, and Confirmatory Factor analysis. Using the recommended cut-off of Zagazig Depression scale for possible minor depression it was found that 30.3% of the students have depression and higher percentage was identified according to the Patient Health Questionnaire (37.4%). Females were more depressed. The mean ZDS score was 8.3 ± 4.2. Rates of depression increase as students get older. The reliability of The ZDS was satisfactory (Cronbach's alpha was .894). For validity, ZDS score was strongly associated with PHQ, with no significant difference (p-value > 0.05), with strong positive correlation (r = +.8, p-value depressive symptoms and is promising for the use of the translated ZDS in a large-scale cross-culture study.

  19. Prospective study establishing a management plan for impacted third molar in patients undergoing hematopoietic stem cell transplantation.

    Science.gov (United States)

    Yamagata, Kenji; Onizawa, Kojiro; Yanagawa, Toru; Takeuchi, Yasutoshi; Hasegawa, Yuichi; Chiba, Shigeru; Bukawa, Hiroki

    2011-02-01

    Although dental treatment before hematopoietic stem cell transplantation (HSCT) is essential to prevent serious infections from oral sources, the best management plan for impacted third molar (ITM) is unclear. This study was planned to establish a management plan for ITM. Eighty-four candidates for HSCT therapy were consecutively enrolled in the prospective trial. The management plan, which was evidence based and prospectively decided, was to extract the symptomatic ITMs and to leave the asymptomatic ones untreated, regardless of their impacted position. Eighty-seven ITMs were observed in 35 patients. The ITMs were in the maxilla of 25 patients and the mandible of 28 patients. Dental extraction of 7 teeth was performed in 6 patients without complications. All of the patients received the scheduled HSCT therapy and none experienced odontogenic infection while myelosuppressed. This management plan for ITM appears to be appropriate for pre-HSCT patients. Moreover, the experienced dental provider is suggested as a necessary and valuable part of the HSCT team. Crown Copyright © 2011. Published by Mosby, Inc. All rights reserved.

  20. A Study on Current Status of Detection Technology and Establishment of National Detection Regime against Nuclear/Radiological Terrorism

    International Nuclear Information System (INIS)

    Kwak, Sung Woo; Jang, Sung Soon; Lee, Joung Hoon; Yoo, Ho Sik

    2009-01-01

    Since 1990s, some events - detection of a dirty bomb in a Russian nation park in 1995, 9/11 terrorist attack to WTC in 2001, discovery of Al-Qaeda's experimentation to build a dirty bomb in 2003 etc - have showed that nuclear or radiological terrorism relating to radioactive materials (hereinafter 'radioactive materials' is referred to as 'nuclear material, nuclear spent fuel and radioactive source') is not incredible but serious and credible threat. Thus, to respond to the new threat, the international community has not only strengthened security and physical protection of radioactive materials but also established prevention of and response to illicit trafficking of radioactive materials. In this regard, our government has enacted or revised the national regulatory framework with a view to improving security of radioactive materials and joined the international convention or agreement to meet this international trend. For the purpose of prevention of nuclear/radiological terrorism, this paper reviews physical characteristics of nuclear material and existing detection instruments used for prevention of illicit trafficking. Finally, national detection regime against nuclear/radiological terrorism based on paths of the smuggled radioactive materials to terrorist's target building/area, national topography and road networks, and defence-in-depth concept is suggested in this paper. This study should contribute to protect people's health, safety and environment from nuclear/radiological terrorism

  1. Populism and Anti-Establishment Politics in Kosovo: A Case Study of Lëvizja Vetëvendosje

    Directory of Open Access Journals (Sweden)

    Bilge Yabanci

    2016-12-01

    Full Text Available Few studies have systematically examined the rising political and social unrest in the Balkans. This paper investigates the local dynamics and consequences of widespread anti-establishment discontent in Kosovo through the analytical framework of populism. By focusing on the case of Lëvizja Vetëvendosje (LVV, the paper sets out to consider two related questions: the unique populist style of the LVV and the complex reasons behind its electoral breakthrough and continuing support among various groups. Based on a qualitative documentary analysis of the party programme, manifesto, party publications, speeches of the leadership and interviews, the paper finds that the LVV successfully melds a populist political style, leftist/social democratic agenda and contentious politics as a means to disperse its message. The second part of the article offers three arguments to explain its appeal: structural factors (electoral availability and party system, societal dynamics (political and economic dissatisfaction and the agency of the LVV (internal organisation, cohesion and leadership. The article contributes to the thriving literature on populism through a novel empirical scope, and to the literature on Southeast Europe through a focus on local agency, voter preferences and party system.

  2. Integrated assessment for establishing an oil environmental vulnerability map: case study for the Santos Basin region, Brazil.

    Science.gov (United States)

    Romero, A F; Abessa, D M S; Fontes, R F C; Silva, G H

    2013-09-15

    The growth of maritime transport and oil exploitation activities may increase the risk of oil spills. Thus, plans and actions to prevent or mitigate impacts are needed to minimize the effects caused by oil. However, tools used worldwide to support contingency plans have not been integrated, thus leading to failure in establishing priority areas. This investigation aimed to develop indices of environmental vulnerability to oil (IEVO), by combining information about environmental sensibility to oil and results of numerical modeling of spilled oil. To achieve that, a case study concerning to oil spills scenarios in a subtropical coastal area was designed, and IEVOs were calculated and presented in maps, in order to make the information about the areas' vulnerability more easily visualized. For summer, the extension of coastline potentially affected by oil was approximately 150 km, and most of the coastline presented medium to high vulnerability. For winter, 230 km coastline would be affected, from which 75% were classified as medium to high vulnerability. Thus, IEVO maps allowed a rapid and clearer interpretation of the vulnerability of the mapped region, facilitating the planning process and the actions in response to an oil spill. Copyright © 2013 Elsevier Ltd. All rights reserved.

  3. Establishing Concurrent Validity of the Role Checklist Version 2 with the OCAIRS in Measurement of Participation: A Pilot Study

    Directory of Open Access Journals (Sweden)

    Patricia J. Scott

    2017-01-01

    Full Text Available Persons experiencing problems with adaptation following disease, disability, or overwhelming life circumstances are often referred by their physicians to occupational therapists. Given time constraints, therapists may skip administration of a client-centered participation focused assessment and instead use an impairment or limitation focused assessment. This approach assumes that skill remediation will naturally lead to return of participation in valued occupational roles because most participation measures take 30 minutes or longer. In response to the need for an efficient measure of desired role participation, this study establishes concurrent validity of the 10–15-minute Role Checklist Version 2 (RCV2: QP with the 50 minute Occupational Circumstances Assessment And Rating Scale (OCAIRS in measuring occupational participation in individuals recovering from surgery following liver transplantation. 20 subjects (mean age of 55 and a mean time-since-transplant of 5.2 months completed both instruments. The hypothesis was supported (r=.63, showing concurrent validity between the OCAIRS and the RCV2: QP. This provides therapists with an efficient, client-centered measure of occupational participation for a client-centered treatment plan. Using the RCV2: QP in place of the OCAIRS provides a more efficient assessment tool for occupational therapists to set treatment goals and monitor client progress over time.

  4. [Establishment of an Animal Based Therapy at a University Hospital for Psychiatry: Results of a Preliminary Study and Future Prospects].

    Science.gov (United States)

    Hartfiel, Cajetan; Bodatsch, Mitja; Klosterkötter, Joachim; Kuhn, Jens

    2017-01-01

    Objective: Dogs have been integrated in human society over centuries. This process has selected unique social and communicative skills. Dogs are thus able to represent social substitutes for human counterparts in cases of social withdrawal. Furthermore, dogs act as "social catalysts" in promoting interhuman encounters. Thus, the integration of dogs in psychotherapeutic concepts addressing social and interpersonal deficits may be of special interest. Methods: The present investigation reports the results of a pilot study to establish animal-assisted therapy (dogs) at a psychiatric department. The animal-assisted intervention straddled the following areas: (1) contact making, communication and orientation to needs, (2) recreation and play, (3) outward orientation, (4) release and farewell. The sample comprised 22 subjects. Results: The results demonstrated in particular that the animal-assisted intervention significantly promoted unspecific aspects of positive affectivity and wellbeing. Evaluation of the overall acceptance of the dog on the psychiatric ward revealed very positive feedback. Conclusions: We conclude that animal-assisted therapies represent a significant enchrichment of the therapeutic context, that may be used to enhance the patients' openness and adherence to conventional therapies. © Georg Thieme Verlag KG Stuttgart · New York.

  5. Establishment of gastro-intestinal helminth infections in free-range chickens: a longitudinal on farm study.

    Science.gov (United States)

    Wongrak, Kalyakorn; Daş, Gürbüz; Moors, Eva; Sohnrey, Birgit; Gauly, Matthias

    2014-01-01

    The objective of this study was to monitor establishment and development of gastro-intestinal helminth infections in chickens over two production years (PY) on a free-range farm in Lower Saxony, Germany. The data were collected between July 2010 and June 2011 (PY1) and July 2011 and January 2013 (PY2), respectively. During PY1, Lohmann Brown classic (LB classic, N = 450) was tested, while in PY2 two different genotypes (230 LB classic, 230 LB plus) were used. The hens were kept in two mobile stalls that were moved to a new position at regular intervals. In both PY1 and PY2, 20 individual faecal samples per stall were randomly collected at monthly intervals in order to calculate the number of internal parasite eggs per gram of faeces (EPG). At the end of the laying periods, approximately 10% (N = 42) or more than 50% (N = 265) of hens were subjected to post-mortem parasitological examinations in PY1 and PY2, respectively. No parasite eggs were found in the faecal samples during PY1, whereas almost all of the hens (97.6%) were infected with Heterakis gallinarum (36 worms/hen) at the end of the period. In PY2, nematode eggs in faeces were found from the third month onwards at a low level, increasing considerably towards the final three months. There was no significant difference between the two genotypes of brown hens neither for EPG (P = 0.456) or for overall prevalence (P = 0.177). Mortality rate ranged from 18.3 to 27.4% but did not differ significantly between genotypes or production years. Average worm burden was 207 worms/hen in PY2. The most prevalent species were H. gallinarum (98.5%) followed by Ascaridia galli (96.2%) and Capillaria spp. (86.1%). Furthermore, three Capillaria species, C. obsignata, C. bursata and C. caudinflata were differentiated. In conclusion chickens kept on free-range farms are exposed to high risks of nematode infections and have high mortality rates with no obvious link to parasite infections. Once the farm environment is contaminated

  6. Establishing an online store in the furniture retail business : Case study of Lähdesmäki Oy

    OpenAIRE

    Kareno, Justus

    2013-01-01

    This thesis describes the process of establishing an online store for a Finnish furniture retailer. The development of electronic commerce as a means of business is introduced as the force driving furniture retailers to establish an online presence. The theory of electronic commerce is presented and analyzed in terms of differences compared to sales via a conventional store. The development of electronic furniture retailing is analyzed by researching furniture retailers in Finland and th...

  7. A study on the establishment of national nuclear foreign policy -with reference to the strategy on the NPT extension and analysis of nuclear liability-

    International Nuclear Information System (INIS)

    Oh, Keun Bae; Choi, Yeong Myeong; Ham, Chol Hoon; Lee, Kwang Seok; Lee, Byeong Uk; Lee, Jae Seong; Choi, Yeong Rok; Ko, Han Seok

    1994-01-01

    The overall objectives of this study are to analyze the international nuclear export control system and the international non-proliferation circumstance, to establish national strategies for the NPT extension, to suggest revisions of the IAEA Statute Article VI giving Korea permanent membership on the IAEA board of Governors, and to analyze and establish counter measurements for nuclear liability in verious fields. (Author)

  8. High Quality Rapeseed Products as Feed for Sensitive Monogastrics

    DEFF Research Database (Denmark)

    Frandsen, Heidi Blok

    in plants of the order Brassicales (former known as Capparales), which include rapeseed, rype (Brassica campestris L.) Indian mustard (Brassica juncea L.), broccoli (Brassica oleracea L.var. italica) and many other plants. Glucosinolates have been studied widely for their biologic effects ranging from...... by xenobiotica enzymes in the liver. The last study (manuscript IV) deals with the novel processing techniques, pulsed electric field (PEF) and high pressure treatment (HPT) and the processing effects on glucosinolates in broccoli. The largest effects were observed to be a result of the different handling...... of the plant materials prior to the process treatment. It was thus found that a great amount of the glucosinolate loss has occurred in the broccoli juice and purée prior to PEF processing. Only a minor loss was observed in broccoli flowers prior to processing, and HP treatment at 700 MPa for 10 min. was found...

  9. High quality broadband spatial reflections of slow Rayleigh surface acoustic waves modulated by a graded grooved surface

    KAUST Repository

    Xu, Yanlong

    2015-01-21

    We report high quality broadband spatial reflections of Rayleigh surface acoustic waves (SAWs) through a graded grooved surface. High quality means that no wave is allowed to transmit and the incident wave is nearly all reflected to the input side. The graded grooved surface is structured by drilling one dimensional array of graded grooves with increased depths on a flat surface. We investigate SAW dispersion relations, wave field distribution at several typical SAW wavelengths, and time evolution of a Gaussian pulse through the graded grooved surface. Results show that the input broadband Rayleigh SAWs can be slowed, spatially enhanced and stopped, and finally reflected to the input side. The study suggests that engraving the flat surface can be used as an efficient and economical way to manipulate Rayleigh SAWs, which has potential application in novel SAW devices such as filters, reflectors, sensors, energy harvesters, and diodes.

  10. A STUDY TO ESTABLISH ASSOCIAT ION OF HYPERGLYCEMIA AND INPATIENT MORTALITY IN PATIENTS WITH UNDIAGNOSED DIABETES MELLITUS

    Directory of Open Access Journals (Sweden)

    Mohd

    2015-06-01

    Full Text Available The aim of this study was to establish the prevalence, survival, and outcome of patients presented with in - hospital hyperglycemia in which there is prior history of diabetes and without a history of diabetes. We reviewed the medical records of 2000 consecu tive adult patients admitted to MNR Medical College, a teaching hospital in Telangana; from Jan 2014 to Nov 2014 and 1886 patients were studied 144 were excluded as glycemic records were not available. New hyperglycemia was defined as fasting glucose level of 126 mg/dl on admission or in - hospital or random blood glucose of more than 200 mg/dl or more on 2 or more determinations. Hyperglycemia was present in 38% of patients admitted to the hospital, of whom 26% had a known history of diabetes, and 11.96% had no history of diabetes before the admission. It was observed that there was higher in - hospital mortality rate (16.21% in newly diagnosed hyperglycemia when compared to known diabetic patients (3.31% and subjects with normoglycemia (1.56%; both P < 0.01. In addition, new hyperglycemic patients had a prolonged hospital stay, a higher admission rate to an intensive care unit, and were less likely to be discharged to home, frequently requiring transfer to a transitional care unit or nursing home facility. Ou r results indicate that in - hospital hyperglycemia is a common finding and represents an important marker of poor clinical outcome and mortality in patients with and without a history of diabetes. Patients with newly diagnosed hyperglycemia had a significan tly higher mortality rate and a lower functional outcome than patients with a known history of diabetes or normoglycemia.

  11. Women's Health Initiative estrogen plus progestin clinical trial: a study that does not allow establishing relevant clinical risks.

    Science.gov (United States)

    Aedo, Sócrates; Cavada, Gabriel; Blümel, Juan E; Chedraui, Peter; Fica, Juan; Barriga, Patricio; Brantes, Sergio; Irribarra, Cristina; Vallejo, María; Campodónico, Ítalo

    2015-12-01

    This study aims to determine time differences (differences in restricted mean survival times [RMSTs]) in the onset of invasive breast cancer, coronary heart disease, stroke, pulmonary embolism, colorectal cancer, and hip fracture between the placebo group and the conjugated equine estrogens 0.625 mg plus medroxyprogesterone acetate 2.5 mg group of the Women's Health Initiative (WHI) trial based on survival curves of the original report and to provide adequate interpretation of the clinical effects of a given intervention. Distribution of survival function was obtained from cumulative hazard plots of the WHI report; Monte Carlo simulation was performed to obtain censored observations for each outcome, in which assumptions of the Cox model were evaluated once corresponding hazard ratios had been estimated. Using estimation methods such as numerical integration, pseudovalues, and flexible parametric modeling, we determined differences in RMSTs for each outcome. Obtained cumulative hazard plots, hazard ratios, and outcome rates from the simulated model did not show differences in relation to the original WHI report. The differences in RMST between placebo and conjugated equine estrogens 0.625 mg plus medroxyprogesterone acetate 2.5 mg (in flexible parametric modeling) were 1.17 days (95% CI, -2.25 to 4.59) for invasive breast cancer, 7.50 days (95% CI, 2.90 to 12.11) for coronary heart disease, 2.75 days (95% CI, -0.84 to 6.34) for stroke, 4.23 days (95% CI, 1.82 to 6.64) for pulmonary embolism, -2.73 days (95% CI, -5.32 to -0.13) for colorectal cancer, and -2.77 days (95% CI, -5.44 to -0.1) for hip fracture. The differences in RMST for the outcomes of the WHI study are too small to establish clinical risks related to hormone therapy use.

  12. Integrated mapping of establishment risk for emerging vector-borne infections: a case study of canine leishmaniasis in southwest France.

    Directory of Open Access Journals (Sweden)

    Nienke Hartemink

    Full Text Available BACKGROUND: Zoonotic visceral leishmaniasis is endemic in the Mediterranean Basin, where the dog is the main reservoir host. The disease's causative agent, Leishmania infantum, is transmitted by blood-feeding female sandflies. This paper reports an integrative study of canine leishmaniasis in a region of France spanning the southwest Massif Central and the northeast Pyrenees, where the vectors are the sandflies Phlebotomus ariasi and P. perniciosus. METHODS: Sandflies were sampled in 2005 using sticky traps placed uniformly over an area of approximately 100 by 150 km. High- and low-resolution satellite data for the area were combined to construct a model of the sandfly data, which was then used to predict sandfly abundance throughout the area on a pixel by pixel basis (resolution of c. 1 km. Using literature- and expert-derived estimates of other variables and parameters, a spatially explicit R(0 map for leishmaniasis was constructed within a Geographical Information System. R(0 is a measure of the risk of establishment of a disease in an area, and it also correlates with the amount of control needed to stop transmission. CONCLUSIONS: To our knowledge, this is the first analysis that combines a vector abundance prediction model, based on remotely-sensed variables measured at different levels of spatial resolution, with a fully mechanistic process-based temperature-dependent R(0 model. The resulting maps should be considered as proofs-of-principle rather than as ready-to-use risk maps, since validation is currently not possible. The described approach, based on integrating several modeling methods, provides a useful new set of tools for the study of the risk of outbreaks of vector-borne diseases.

  13. Fabrication of high quality ordered porous anodic aluminum oxide templates

    International Nuclear Information System (INIS)

    Liu Kai; Du Kai; Chen Jing; Zhou Lan; Zhang Lin; Fang Yu

    2010-01-01

    The preparation of porous anodic aluminum oxide (AAO) templates has been studied with oxalic acid as electrolyte. The morphology of the as-prepared templates has been characterized by field-emission scanning electron microscope (FE-SEM). The pores distributed orderly and uniformly with the diameter ranging from 40 nm to 70 nm. The experimental results indicate that electrolyte concentration, oxidation voltage, oxidation temperature and oxidation time affect the structure of AAO templates. Ordered porous AAO templates can be derived without annealing and finishing. X-ray diffraction (XRD) analysis indicates that the aluminum oxide film is mainly composed of amorphous Al 2 O 3 . (authors)

  14. A study to analyze IAEA planning of 2004-2005 programme and to establish cooperation directions with the IAEA

    Energy Technology Data Exchange (ETDEWEB)

    Oh, K. B.; Lee, K. S.; Lee, B. W.; Ko, H. S.; Ryu, J. S.; Lee, T. J.; Kim, M. R

    2003-07-01

    The objective of this study is to utilize the IAEA effectively through reflecting Korea's opinion fully for the planning of the Agency's 2004{approx}2005 Programme. This study first analyzed the current status of the IAEA Programme and Budget and reviewed the issues relevant to Korea. Second, this study assessed the IAEA 2004{approx}2005 Programme and drew up Korea's opinion for it. The official document including the opinions was submitted to the Secretariat. In reviewing the Programme, this study considered the strengths of Korea related to the Programme. Also some projects and CRPs, which can be lead by Korea, were proposed. The IAEA 2004{approx}2005 Programme reflected well the technical and social changes and its structure seems to be proper. The budget was proposed to be increased over 10%, violating the zero-real growth principle. This seems to be inevitable considering the increase of safeguards activities. However, there should be prepared some measures to avoid rapid increase of the burdens of the Member States. In the process of the planning of the IAEA 2004{approx}2005 Programme, the following points should be emphasized. First, SMR activities should be given a high priority considering the high interests of developing countries and be set up as a separate project as in the 2002{approx}2003 Programme. Second, more budget should be allocated for Project A.4.04(Support for demonstration of nuclear seawater desalination), considering the highest priority of the project in Program A. Third, it's better to change the title of Subprogram C.3 to 'Nuclear knowledge Preservation' to stick to the original rationale of the subprogram. There is a need for further activities such as establishing and implementing the concept of international nuclear school based on the result of the feasibility study done in 2002{approx}2003. Fourth, further activities needs to be added to the Project D.2.03 for the efficient conversion to high density

  15. A study to analyze IAEA planning of 2004-2005 programme and to establish cooperation directions with the IAEA

    International Nuclear Information System (INIS)

    Oh, K. B.; Lee, K. S.; Lee, B. W.; Ko, H. S.; Ryu, J. S.; Lee, T. J.; Kim, M. R.

    2003-07-01

    The objective of this study is to utilize the IAEA effectively through reflecting Korea's opinion fully for the planning of the Agency's 2004∼2005 Programme. This study first analyzed the current status of the IAEA Programme and Budget and reviewed the issues relevant to Korea. Second, this study assessed the IAEA 2004∼2005 Programme and drew up Korea's opinion for it. The official document including the opinions was submitted to the Secretariat. In reviewing the Programme, this study considered the strengths of Korea related to the Programme. Also some projects and CRPs, which can be lead by Korea, were proposed. The IAEA 2004∼2005 Programme reflected well the technical and social changes and its structure seems to be proper. The budget was proposed to be increased over 10%, violating the zero-real growth principle. This seems to be inevitable considering the increase of safeguards activities. However, there should be prepared some measures to avoid rapid increase of the burdens of the Member States. In the process of the planning of the IAEA 2004∼2005 Programme, the following points should be emphasized. First, SMR activities should be given a high priority considering the high interests of developing countries and be set up as a separate project as in the 2002∼2003 Programme. Second, more budget should be allocated for Project A.4.04(Support for demonstration of nuclear seawater desalination), considering the highest priority of the project in Program A. Third, it's better to change the title of Subprogram C.3 to 'Nuclear knowledge Preservation' to stick to the original rationale of the subprogram. There is a need for further activities such as establishing and implementing the concept of international nuclear school based on the result of the feasibility study done in 2002∼2003. Fourth, further activities needs to be added to the Project D.2.03 for the efficient conversion to high density, low enriched uranium in Member States; for instance, review

  16. The structure of high-quality aluminium cast iron

    Directory of Open Access Journals (Sweden)

    D. Kopyciński

    2012-01-01

    Full Text Available In this study presents the analyse of aluminium iron cast structure (as-cast condition which are used in high temperature. While producing the casts of aluminium iron major influence has been preserve the structure of technological process parameters. The addition to Fe-C-Al alloy V, Ti, Cr leads to the improvement of functional and mechanical cast qualities. In this study, a method was investigated to eliminate the presence of undesirable Al4C3 phases in a aluminium cast iron structure and thus improve the production process. V and Ti additions in aluminium cast iron allows to development of FeAl - VC or TiC alloys. In particular, V or Ti contents above 5 wt.% were found to totally eliminate the presence of Al4C3. In addition, preliminary work indicates that the alloy with the FeAl - VC or TiC structure reveals high oxidation resistance. The introduction of 5 wt.% chromium to aluminium cast iron strengthened Al4C3 precipitate. Thus, the resultant alloy can be considered an intermetallic FeAl matrix strengthened by VC and TiC or modified Al4C3 reinforcements.

  17. Academic coordination at university: Strategies for high quality education

    Directory of Open Access Journals (Sweden)

    Maria del Mar Durán Bellonch

    2009-08-01

    Full Text Available Most lecturers and professors involved in teaching School Management and Education Management courses have been engaged in developing some innovative actions to improve the training quality that we offer to students in the Pedagogy degree at the Autonomous University of Barcelona. These actions are aimed at increasing co-ordination among the teaching staff when designing and implementing the course curricula. Co-ordination meetings, exchanges of teaching experiences, discussions about what, how and when to teach the different contents, in which courses and at what level, methodological issues pointed out through technical description cards or the elaboration of study cases to be solved have become the basis of relevant actions during the last academic years. This paper explains each one of them, and provides useful information about the theoretical background, the process carried out, some of the results obtained, the output and the tools created.

  18. A Filtration-based Method of Preparing High-quality Nuclei from Cross-linked Skeletal Muscle for Chromatin Immunoprecipitation.

    Science.gov (United States)

    Nohara, Kazunari; Chen, Zheng; Yoo, Seung-Hee

    2017-07-06

    Chromatin immunoprecipitation (ChIP) is a powerful method to determine protein binding to chromatin DNA. Fiber-rich skeletal muscle, however, has been a challenge for ChIP due to technical difficulty in isolation of high-quality nuclei with minimal contamination of myofibrils. Previous protocols have attempted to purify nuclei before cross-linking, which incurs the risk of altered DNA-protein interaction during the prolonged nuclei preparation process. In the current protocol, we first cross-linked the skeletal muscle tissue collected from mice, and the tissues were minced and sonicated. Since we found that ultracentrifugation was not able to separate nuclei from myofibrils using cross-linked muscle tissue, we devised a sequential filtration procedure to obtain high-quality nuclei devoid of significant myofibril contamination. We subsequently prepared chromatin by using an ultrasonicator, and ChIP assays with anti-BMAL1 antibody revealed robust circadian binding pattern of BMAL1 to target gene promoters. This filtration protocol constitutes an easily applicable method to isolate high-quality nuclei from cross-linked skeletal muscle tissue, allowing consistent sample processing for circadian and other time-sensitive studies. In combination with next-generation sequencing (NGS), our method can be deployed for various mechanistic and genomic studies focusing on skeletal muscle function.

  19. Feasibility of establishing an Australian ACL registry: a pilot study by the Australian Orthopaedic Association National Joint Replacement Registry (AOANJRR).

    Science.gov (United States)

    Lekkas, Christina; Clarnette, Richard; Graves, Stephen E; Rainbird, Sophia; Parker, David; Lorimer, Michelle; Paterson, Roger; Roe, Justin; Morris, Hayden; Feller, Julian A; Annear, Peter; Forster, Ben; Hayes, David

    2017-05-01

    Rupture of the anterior cruciate ligament (ACL) is a common and debilitating injury that impacts significantly on knee function and risks the development of degenerative arthritis. The outcome of ACL surgery is not monitored in Australia. The optimal treatment is unknown. Consequently, the identification of best practice in treating ACL is crucial to the development of improved outcomes. The Australian Knee Society (AKS) asked the Australian Orthopaedic Association (AOA) to consider establishing a national ACL registry. As a first step, a pilot study was undertaken by the Australian Orthopaedic Association National Joint Replacement Registry (AOANJRR) to test the hypothesis that collecting the required information in the Australian setting was possible. Surgeons completed an operative form which provided comprehensive information on the surgery undertaken. Patients provided pre- and post-operative questionnaires including the Knee Injury and Osteoarthritis Outcome Score (KOOS) and the Marx Activity Scale (MA Scale). The number of ACL procedures undertaken at each hospital during the recruitment period was compared against State Government Health Department separation data. A total of 802 patients were recruited from October 2011 to January 2013. The overall capture rate for surgeon-derived data was 99%, and the capture rate for the pre-operative patient questionnaire was 97.9%. At 6 months, patient-reported outcomes were obtained from 55% of patients, and 58.5% of patients at 12 months. When checked against State Government Health Department separation data, 31.3% of procedures undertaken at each study hospital were captured in the study. It is possible to collect surgeon-derived and pre-operative patient-reported data, following ACL reconstruction in Australia. The need to gain patient consent was a limiting factor to participation. When patients did consent to participate in the study, we were able to capture nearly 100% of surgical procedures. Patient consent

  20. Establishing the tolerability and performance of tamarind seed polysaccharide (TSP in treating dry eye syndrome: results of a clinical study

    Directory of Open Access Journals (Sweden)

    Valente Cristiana

    2007-03-01

    Full Text Available Abstract Background One of the problems arising from available preparations for dry eye syndrome is the limited residence time of products on the ocular surface. In this paper, we look at an innovative new treatment for dry eye, tamarind seed polysaccharide (TSP. TSP possesses mucomimetic, mucoadhesive and pseudoplastic properties. The 'mucin-like' molecular structure of TSP is similar to corneal and conjunctival mucin 1 (MUC1, a transmembrane glycoprotein thought to play an essential role in protecting and wetting the corneal surface and may explain its increased retention on the eye surface. Methods The activity of TSP and hyaluronic acid (HA in the treatment of dry eye syndrome was compared in an open-label, randomised, single-centre clinical study. Thirty patients were randomised to receive three or more applications per day of either TSP 0.5%, TSP 1% or HA 0.2% (Hyalistil™ over a period of 90 days. The primary objective of tolerability was assessed by visual analogue scale (VAS, scoring of specific symptoms and the incidence of adverse events. Secondary objectives included improvement in stability of the precorneal tear film, subjective symptoms and corneal and conjunctival staining. Results TSP 0.5% and 1% were comparable to HA 0.2% with regard to both primary and secondary objective parameters. TSP 1% showed benefits over HA 0.2% for the subjective symptoms; trouble blinking, ocular burning and foreign body sensation. Conclusion This study suggests that TSP 0.5% and 1% offer at least equivalent relief to HA 0.2% for dry eye syndrome. All treatments demonstrated optimal tolerability and are suitable for frequent use in the therapy of dry eye. TSP 1% produced promising results in terms of improvements in certain patient symptoms and suggests benefits of the TSP formulation. This study paves the way for a larger study to further establish the performance and safety of TSP compared with HA and highlights the need to expand this therapeutic

  1. Characterization of non equilibrium effects on high quality critical flows

    International Nuclear Information System (INIS)

    Camelo, E.; Lemonnier, H.; Ochterbeck, J.

    1995-01-01

    The appropriate design of various pieces of safety equipment such as relief systems, relies on the accurate description of critical flow phenomena. Most of the systems of industrial interest are willing to be described by one-dimensional area-averaged models and a large fraction of them involves multi-component high gas quality flows. Within these circumstances, the flow is very likely to be of an annular dispersed nature and its description by two-fluid models requires various closure relations. Among the most sensitive closures, there is the interfacial area and the liquid entrained fraction. The critical flowrate depends tremendously on the accurate description of the non equilibrium which results from the correctness of the closure equations. In this study, two-component flows are emphasized and non equilibrium results mainly form the differences in the phase velocities. It is therefore of the utmost importance to have reliable data to characterize non equilibrium phenomena and to assess the validity of the closure models. A comprehensive description of air-water nozzle flows, with emphasis on the effect of the nozzle geometry, has been undertaken and some of the results are presented here which helps understanding the overall flow dynamics. Besides the critical flowrate, the presented material includes pressure profiles, droplet size and velocity, liquid film flowrate and liquid film thickness

  2. Innovative process routes for a high-quality concrete recycling.

    Science.gov (United States)

    Menard, Y; Bru, K; Touze, S; Lemoign, A; Poirier, J E; Ruffie, G; Bonnaudin, F; Von Der Weid, F

    2013-06-01

    This study presents alternative methods for the processing of concrete waste. The mechanical stresses needed for the embrittlement of the mortar matrix and further selective crushing of concrete were generated by either electric impulses or microwaves heating. Tests were carried out on lab-made concrete samples representative of concrete waste from concrete mixer trucks and on concrete waste collected on a French demolition site. The results obtained so far show that both techniques can be used to weaken concrete samples and to enhance aggregate selective liberation (that is the production of cement paste-free aggregates) during crushing and grinding. Electric pulses treatment seems to appear more efficient, more robust and less energy consuming (1-3 kWh t(-1)) than microwave treatment (10-40 kWh t(-1)) but it can only be applied on samples in water leading to a major drawback for recycling aggregates or cement paste in the cement production process. Copyright © 2013 Elsevier Ltd. All rights reserved.

  3. Characterization of non equilibrium effects on high quality critical flows

    Energy Technology Data Exchange (ETDEWEB)

    Camelo, E.; Lemonnier, H.; Ochterbeck, J. [Commissariat a l Energie Atomique, Grenoble (France)] [and others

    1995-09-01

    The appropriate design of various pieces of safety equipment such as relief systems, relies on the accurate description of critical flow phenomena. Most of the systems of industrial interest are willing to be described by one-dimensional area-averaged models and a large fraction of them involves multi-component high gas quality flows. Within these circumstances, the flow is very likely to be of an annular dispersed nature and its description by two-fluid models requires various closure relations. Among the most sensitive closures, there is the interfacial area and the liquid entrained fraction. The critical flowrate depends tremendously on the accurate description of the non equilibrium which results from the correctness of the closure equations. In this study, two-component flows are emphasized and non equilibrium results mainly form the differences in the phase velocities. It is therefore of the utmost importance to have reliable data to characterize non equilibrium phenomena and to assess the validity of the closure models. A comprehensive description of air-water nozzle flows, with emphasis on the effect of the nozzle geometry, has been undertaken and some of the results are presented here which helps understanding the overall flow dynamics. Besides the critical flowrate, the presented material includes pressure profiles, droplet size and velocity, liquid film flowrate and liquid film thickness.

  4. Production of high quality sodium iodide preparations labelled with carrier free iodine-125

    International Nuclear Information System (INIS)

    Abdukayumov, M.N.; Chistyakov, P.G.; Shilin, E.A.

    2001-01-01

    Work is related to the problem of high-quality Sodium Iodide preparation production and to the choice of the peptids iodination methods with the purpose of control test developing to determine the Biological activity of the above mentioned preparation

  5. The Role of Dosimetry in High-Quality EMI Risk Assessment

    National Research Council Canada - National Science Library

    2006-01-01

    The Final Proceedings for The role of EMF dosimetry in high quality risk assessment 13 September 2006 - 15 September 2006 In the last three decades the use of devices that emit electromagnetic fields (EMF...

  6. Reliable Exfoliation of Large-Area High-Quality Flakes of Graphene and Other Two-Dimensional Materials.

    Science.gov (United States)

    Huang, Yuan; Sutter, Eli; Shi, Norman N; Zheng, Jiabao; Yang, Tianzhong; Englund, Dirk; Gao, Hong-Jun; Sutter, Peter

    2015-11-24

    Mechanical exfoliation has been a key enabler of the exploration of the properties of two-dimensional materials, such as graphene, by providing routine access to high-quality material. The original exfoliation method, which remained largely unchanged during the past decade, provides relatively small flakes with moderate yield. Here, we report a modified approach for exfoliating thin monolayer and few-layer flakes from layered crystals. Our method introduces two process steps that enhance and homogenize the adhesion force between the outermost sheet in contact with a substrate: Prior to exfoliation, ambient adsorbates are effectively removed from the substrate by oxygen plasma cleaning, and an additional heat treatment maximizes the uniform contact area at the interface between the source crystal and the substrate. For graphene exfoliation, these simple process steps increased the yield and the area of the transferred flakes by more than 50 times compared to the established exfoliation methods. Raman and AFM characterization shows that the graphene flakes are of similar high quality as those obtained in previous reports. Graphene field-effect devices were fabricated and measured with back-gating and solution top-gating, yielding mobilities of ∼4000 and 12,000 cm(2)/(V s), respectively, and thus demonstrating excellent electrical properties. Experiments with other layered crystals, e.g., a bismuth strontium calcium copper oxide (BSCCO) superconductor, show enhancements in exfoliation yield and flake area similar to those for graphene, suggesting that our modified exfoliation method provides an effective way for producing large area, high-quality flakes of a wide range of 2D materials.

  7. Universal and rapid salt-extraction of high quality genomic DNA for PCR-based techniques.

    OpenAIRE

    Aljanabi, S M; Martinez, I

    1997-01-01

    A very simple, fast, universally applicable and reproducible method to extract high quality megabase genomic DNA from different organisms is described. We applied the same method to extract high quality complex genomic DNA from different tissues (wheat, barley, potato, beans, pear and almond leaves as well as fungi, insects and shrimps' fresh tissue) without any modification. The method does not require expensive and environmentally hazardous reagents and equipment. It can be performed even i...

  8. [Quality management is associated with high quality services in health care].

    Science.gov (United States)

    Nielsen, Tenna Hassert; Riis, Allan; Mainz, Jan; Jensen, Anne-Louise Degn

    2013-12-09

    In these years, quality management has been the focus in order to meet high quality services for the patients in Danish health care. This article provides information on quality management and quality improvement and it evaluates its effectiveness in achieving better organizational structures, processes and results in Danish health-care organizations. Our findings generally support that quality management is associated with high quality services in health care.

  9. Establishment path and management innovation of mutually beneficial nonprofit organization (MBNPO: A study based on integrated marketing communications (IMC theory

    Directory of Open Access Journals (Sweden)

    Kwang-yong Shin

    2017-05-01

    Full Text Available Purpose - Research about the modern mutually beneficial nonprofit organizations (MBNPOs has great value because of the increasingly important role that the MBNPO plays in society. The establishment and management of MBNPOs are critical for its development. Design/methodology/approach - Integrated marketing communications (IMC theory is applied to the research on establishment and management innovation. The establishment of MBNPOs needs four sequential steps: identifying the target group, providing services to meet the demand of stakeholders, designing appropriate communication tactics and deploying proper organizational structure to accomplish efficient communication. Findings - Three types of approach enable traditional enterprises to transform into MBNPOs: product innovation, operational innovation and synergetic development. The application of IMC theory accomplishes management innovation of MBNPOs in three aspects: leading market-orientation specific to stakeholder-orientation, making management innovation systematic in MBNPOs and clarifying targets of management innovation in MBNPOs. Originality/value - This is one of the first examinations of establishment path and management innovation of MBNPO based on IMC theory.

  10. Enhancing Established Counting Routines to Promote Place-Value Understanding: An Empirical Study in Early Elementary Classrooms

    Science.gov (United States)

    Fraivillig, Judith L.

    2018-01-01

    Understanding place value is a critical and foundational competency for elementary mathematics. Classroom teachers who endeavor to promote place-value development adopt a variety of established practices to varying degrees of effectiveness. In parallel, researchers have validated models of how young children acquire place-value understanding.…

  11. A Feasibility Study on the Establishment of a Fire Fighting Academy for the State of New Mexico.

    Science.gov (United States)

    Sanchez, Alex A.

    The report on the desirability and feasibility of establishing the New Mexico State Fire Academy and firemen training program is presented in three parts: (1) the result of a survey of firemen training, (2) a proposal for a total system of firemen training, and (3) an analysis of the cost of implementing this program of training and education. The…

  12. Achieving Ohmic Contact for High-quality MoS2 Devices on Hexagonal Boron Nitride

    Science.gov (United States)

    Cui, Xu

    highly stable device performance, even at elevated temperatures. Both optical and electrical characterization confirms our high quality devices, including an ultra-clean interface, a record-high Hall mobility reaching 34,000 cm. 2/Vs, and first observation of Shubnikov–de Haas oscillations. The development of Ohmic contact and fabrication of high quality devices are critical to MoS2 application and studying its intrinsic properties. Therefore, the progress made in this work will facilitate efforts to study novel physical phenomena of MoS2 that were not accessible before.

  13. Surface states in the photoionization of high-quality CdSe core/shell nanocrystals.

    Science.gov (United States)

    Li, Shu; Steigerwald, Michael L; Brus, Louis E

    2009-05-26

    We use electric force microscopy (EFM) to study single nanocrystal photoionization in two classes of high-quality nanocrystals whose exciton luminescence quantum yields approach unity in solution. The CdSe/CdS/ZnS core/shell nanocrystals do not photoionize, while the CdSe/CdS nanocrystals do show substantial photoionization. This verifies the theoretical prediction that the ZnS shell confines the excited electron within the nanocrystal. Despite the high luminescence quantum yield, photoionization varies substantially among the CdSe/CdS nanocrystals. We have studied the nanocrystal photoionization with both UV (396 nm) and green (532 nm) light, and we have found that the magnitude of the charge due to photoionization per absorbed photon is greater for UV excitation than for green excitation. A fraction of the photoionization occurs directly via a "hot electron" process, using trap states that are either on the particle surface, within the ligand sphere, or within the silicon oxide layer. This must occur without relaxation to the thermalized, lowest-energy, emitting exciton. We discuss the occurrence of hot carrier processes that are common to photoionization, luminescence blinking, and the fast transient optical absorption that is associated with multiple exciton generation MEG studies.

  14. A study on the establishment of safety assessment guidelines of commercial grade item dedication in digitalized safety systems

    International Nuclear Information System (INIS)

    Hwang, H. S.; Kim, B. R.; Oh, S. H.

    1999-01-01

    Because of obsolescing the components used in safety related systems of nuclear power plants, decreasing the number of suppliers qualified for the nuclear QA program and increasing maintenance costs of them, utilities have been considering to use commercial grade digital computers as an alternative for resolving such issues. However, commercial digital computers use the embedded pre-existing software, including operating system software, which are not developed by using nuclear grade QA program. Thus, it is necessary for utilities to establish processes for dedicating digital commercial grade items. A regulatory body also needs guidance to evaluate the digital commercial products properly. This paper surveyed the regulations and their regulatory guides, which establish the requirements for commercial grade items dedication, industry standards and guidances applicable to safety related systems. This paper provides some guidelines to be applied in evaluating the safety of digital upgrades and new digital plant protection systems in Korea

  15. Fifteen Challenges in Establishing a Multidisciplinary Research Program on eHealth Research in a University Setting: A Case Study.

    Science.gov (United States)

    Grönqvist, Helena; Olsson, Erik Martin Gustaf; Johansson, Birgitta; Held, Claes; Sjöström, Jonas; Lindahl Norberg, Annika; Hovén, Emma; Sanderman, Robbert; van Achterberg, Theo; von Essen, Louise

    2017-05-23

    U-CARE is a multidisciplinary eHealth research program that involves the disciplines of caring science, clinical psychology, health economics, information systems, and medical science. It was set up from scratch in a university setting in 2010, funded by a governmental initiative. While establishing the research program, many challenges were faced. Systematic documentation of experiences from establishing new research environments is scarce. The aim of this paper was to describe the challenges of establishing a publicly funded multidisciplinary eHealth research environment. Researchers involved in developing the research program U-CARE identified challenges in the formal documentation and by reflecting on their experience of developing the program. The authors discussed the content and organization of challenges into themes until consensus was reached. The authors identified 15 major challenges, some general to establishing a new research environment and some specific for multidisciplinary eHealth programs. The challenges were organized into 6 themes: Organization, Communication, Implementation, Legislation, Software development, and Multidisciplinarity. Several challenges were faced during the development of the program and several accomplishments were made. By sharing our experience, we hope to help other research groups embarking on a similar journey to be prepared for some of the challenges they are likely to face on their way. ©Helena Grönqvist, Erik Martin Gustaf Olsson, Birgitta Johansson, Claes Held, Jonas Sjöström, Annika Lindahl Norberg, Emma Hovén, Robbert Sanderman, Theo van Achterberg, Louise von Essen. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 23.05.2017.

  16. A study on joint exhibition and establishment of the future knowledge infrastructure system between the IAEA and Korea

    International Nuclear Information System (INIS)

    Han, K. W.; Lee, E. J.; Lee, H. Y.

    2003-12-01

    The objectives of the project are to suggest a proposal for future cooperation of establishment of nuclear knowledge infrastructure system to the IAEA and to have a joint technical exhibition on nuclear knowledge management and future nuclear education training with the Agency on the occasion of the 47th General Conference of the Agency in 2003. In order to suggest a proposal for future cooperation of establishment of nuclear knowledge infrastructure system to the IAEA, firstly, Korea will seek to make a coordinator role in the establishment of Asian Network for Higher Education in Nuclear Technology(ANENT) which is sponsored by the Agency, secondly, Korea will participate in the project on the establishment of World Nuclear University sponsored by the Agency and World Nuclear Association, thirdly, Korea will host the IAEA training events on nuclear knowledge management to provide its technical capability for the IAEA member states. For the implementation of a joint technical exhibition which contain the above contexts, Korea will identify the exhibition topics and methods and will produce a video film in English, and will show several new education models such as cyber education system, simulator training using virtual reality technology, and education using network methodology. Futhermore, NTC/KAERI has conducted successfully a joint technical exhibition on nuclear knowledge management and future nuclear education training at the 47th IAEA General Conference in Vienna. Director General of the IAEA, Dr. Mohamed Elbaradei, commented that Korea's effort for preservation knowledge in the field of the nuclear field is a worthy endeavor which have the full support of the IAEA

  17. Approach for growth of high-quality and large protein crystals

    Energy Technology Data Exchange (ETDEWEB)

    Matsumura, Hiroyoshi, E-mail: matsumura@chem.eng.osaka-u.ac.jp [Graduate School of Engineering, Osaka University, Suita, Osaka 565-0871 (Japan); JST (Japan); SOSHO Inc., Osaka 541-0053 (Japan); Sugiyama, Shigeru; Hirose, Mika; Kakinouchi, Keisuke; Maruyama, Mihoko; Murai, Ryota [Graduate School of Engineering, Osaka University, Suita, Osaka 565-0871 (Japan); JST (Japan); Adachi, Hiroaki; Takano, Kazufumi [Graduate School of Engineering, Osaka University, Suita, Osaka 565-0871 (Japan); JST (Japan); SOSHO Inc., Osaka 541-0053 (Japan); Murakami, Satoshi [JST (Japan); SOSHO Inc., Osaka 541-0053 (Japan); Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Nagatsuta, Midori-ku, Yokohama 226-8501 (Japan); Mori, Yusuke; Inoue, Tsuyoshi [Graduate School of Engineering, Osaka University, Suita, Osaka 565-0871 (Japan); JST (Japan); SOSHO Inc., Osaka 541-0053 (Japan)

    2011-01-01

    Three crystallization methods, including crystallization in the presence of a semi-solid agarose gel, top-seeded solution growth (TSSG) and a large-scale hanging-drop method, have previously been presented. In this study, crystallization has been further evaluated in the presence of a semi-solid agarose gel by crystallizing additional proteins. A novel crystallization method combining TSSG and the large-scale hanging-drop method has also been developed. Three crystallization methods for growing large high-quality protein crystals, i.e. crystallization in the presence of a semi-solid agarose gel, top-seeded solution growth (TSSG) and a large-scale hanging-drop method, have previously been presented. In this study the effectiveness of crystallization in the presence of a semi-solid agarose gel has been further evaluated by crystallizing additional proteins in the presence of 2.0% (w/v) agarose gel, resulting in complete gelification with high mechanical strength. In TSSG the seed crystals are hung by a seed holder protruding from the top of the growth vessel to prevent polycrystallization. In the large-scale hanging-drop method, a cut pipette tip was used to maintain large-scale droplets consisting of protein–precipitant solution. Here a novel crystallization method that combines TSSG and the large-scale hanging-drop method is reported. A large and single crystal of lysozyme was obtained by this method.

  18. A High-Quality Reference Genome for the Invasive Mosquitofish Gambusia affinis Using a Chicago Library.

    Science.gov (United States)

    Hoffberg, Sandra L; Troendle, Nicholas J; Glenn, Travis C; Mahmud, Ousman; Louha, Swarnali; Chalopin, Domitille; Bennetzen, Jeffrey L; Mauricio, Rodney

    2018-04-27

    The western mosquitofish, Gambusia affinis, is a freshwater poecilid fish native to the southeastern United States but with a global distribution due to widespread human introduction. Gambusia affinis has been used as a model species for a broad range of evolutionary and ecological studies. We sequenced the genome of a male G. affinis to facilitate genetic studies in diverse fields including invasion biology and comparative genetics. We generated Illumina short read data from paired-end libraries and in vitro proximity-ligation libraries. We obtained 54.9× coverage, N50 contig length of 17.6 kb, and N50 scaffold length of 6.65 Mb. Compared to two other species in the Poeciliidae family, G. affinis has slightly fewer genes that have shorter total, exon, and intron length on average. Using a set of universal single-copy orthologs in fish genomes, we found 95.5% of these genes were complete in the G. affinis assembly. The number of transposable elements in the G. affinis assembly is similar to those of closely related species. The high-quality genome sequence and annotations we report will be valuable resources for scientists to map the genetic architecture of traits of interest in this species. Copyright © 2018, G3: Genes, Genomes, Genetics.

  19. A High-Quality Reference Genome for the Invasive Mosquitofish Gambusia affinis Using a Chicago Library

    Directory of Open Access Journals (Sweden)

    Sandra L. Hoffberg

    2018-06-01

    Full Text Available The western mosquitofish, Gambusia affinis, is a freshwater poecilid fish native to the southeastern United States but with a global distribution due to widespread human introduction. Gambusia affinis has been used as a model species for a broad range of evolutionary and ecological studies. We sequenced the genome of a male G. affinis to facilitate genetic studies in diverse fields including invasion biology and comparative genetics. We generated Illumina short read data from paired-end libraries and in vitro proximity-ligation libraries. We obtained 54.9× coverage, N50 contig length of 17.6 kb, and N50 scaffold length of 6.65 Mb. Compared to two other species in the Poeciliidae family, G. affinis has slightly fewer genes that have shorter total, exon, and intron length on average. Using a set of universal single-copy orthologs in fish genomes, we found 95.5% of these genes were complete in the G. affinis assembly. The number of transposable elements in the G. affinis assembly is similar to those of closely related species. The high-quality genome sequence and annotations we report will be valuable resources for scientists to map the genetic architecture of traits of interest in this species.

  20. Formation of high-quality self-assembled monolayers of conjugated dithiols on gold: base matters.

    Science.gov (United States)

    Valkenier, Hennie; Huisman, Everardus H; van Hal, Paul A; de Leeuw, Dago M; Chiechi, Ryan C; Hummelen, Jan C

    2011-04-06

    This Article reports a systematic study on the formation of self-assembled monolayers (SAMs) of conjugated molecules for molecular electronic (ME) devices. We monitored the deprotection reaction of acetyl protected dithiols of oligophenylene ethynylenes (OPEs) in solution using two different bases and studied the quality of the resulting SAMs on gold. We found that the optimal conditions to reproducibly form dense, high-quality monolayers are 9-15% triethylamine (Et(3)N) in THF. The deprotection base tetrabutylammonium hydroxide (Bu(4)NOH) leads to less dense SAMs and the incorporation of Bu(4)N into the monolayer. Furthermore, our results show the importance of the equilibrium concentrations of (di)thiolate in solution on the quality of the SAM. To demonstrate the relevance of these results for molecular electronics applications, large-area molecular junctions were fabricated using no base, Et(3)N, and Bu(4)NOH. The magnitude of the current-densities in these devices is highly dependent on the base. A value of β=0.15 Å(-1) for the exponential decay of the current-density of OPEs of varying length formed using Et(3)N was obtained. © 2011 American Chemical Society

  1. High-quality total RNA isolation from melon (Cucumis melo L. fruits rich in polysaccharides

    Directory of Open Access Journals (Sweden)

    Gabrielle Silveira de Campos

    2017-08-01

    Full Text Available Melon, a member of the family Cucurbitaceae, is the fourth most important fruit in the world market and, on a volume basis, is Brazil’s main fresh fruit export. Many molecular techniques used to understand the maturation of these fruits require high concentrations of highly purified RNA. However, melons are rich in polyphenolic compounds and polysaccharides, which interfere with RNA extraction. This study aimed to determine the most appropriate method for total RNA extraction from melon fruits. Six extraction buffers were tested: T1 guanidine thiocyanate/phenol/chloroform; T2 sodium azide/?-mercaptoethanol; T3 phenol/guanidine thiocyanate; T4 CTAB/PVP/?-mercaptoethanol; T5 SDS/sodium perchlorate/PVP/?-mercaptoethanol, and T6 sarkosyl/PVP/guanidine thiocyanate, using the AxyPrepTM Multisource Total RNA Miniprep Kit. The best method for extracting RNA from both mature and green fruit was based on the SDS/PVP/?-mercaptoethanol buffer, because it rapidly generated a high quality and quantity of material. In general, higher amounts of RNA were obtained from green than mature fruits, probably due to the lower concentration of polysaccharides and water. The purified material can be used as a template in molecular techniques, such as microarrays, RT-PCR, and in the construction of cDNA and RNA-seq data.

  2. High Yield Chemical Vapor Deposition Growth of High Quality Large-Area AB Stacked Bilayer Graphene

    Science.gov (United States)

    Liu, Lixin; Zhou, Hailong; Cheng, Rui; Yu, Woo Jong; Liu, Yuan; Chen, Yu; Shaw, Jonathan; Zhong, Xing; Huang, Yu; Duan, Xiangfeng

    2012-01-01

    Bernal stacked (AB stacked) bilayer graphene is of significant interest for functional electronic and photonic devices due to the feasibility to continuously tune its band gap with a vertical electrical field. Mechanical exfoliation can be used to produce AB stacked bilayer graphene flakes but typically with the sizes limited to a few micrometers. Chemical vapor deposition (CVD) has been recently explored for the synthesis of bilayer graphene but usually with limited coverage and a mixture of AB and randomly stacked structures. Herein we report a rational approach to produce large-area high quality AB stacked bilayer graphene. We show that the self-limiting effect of graphene growth on Cu foil can be broken by using a high H2/CH4 ratio in a low pressure CVD process to enable the continued growth of bilayer graphene. A high temperature and low pressure nucleation step is found to be critical for the formation of bilayer graphene nuclei with high AB stacking ratio. A rational design of a two-step CVD process is developed for the growth of bilayer graphene with high AB stacking ratio (up to 90 %) and high coverage (up to 99 %). The electrical transport studies demonstrated that devices made of the as-grown bilayer graphene exhibit typical characteristics of AB stacked bilayer graphene with the highest carrier mobility exceeding 4,000 cm2/V·s at room temperature, comparable to that of the exfoliated bilayer graphene. PMID:22906199

  3. Teolenn: an efficient and customizable workflow to design high-quality probes for microarray experiments

    Science.gov (United States)

    Jourdren, Laurent; Duclos, Aurélie; Brion, Christian; Portnoy, Thomas; Mathis, Hugues; Margeot, Antoine; Le Crom, Stéphane

    2010-01-01

    Despite the development of new high-throughput sequencing techniques, microarrays are still attractive tools to study small genome organisms, thanks to sample multiplexing and high-feature densities. However, the oligonucleotide design remains a delicate step for most users. A vast array of software is available to deal with this problem, but each program is developed with its own strategy, which makes the choice of the best solution difficult. Here we describe Teolenn, a universal probe design workflow developed with a flexible and customizable module organization allowing fixed or variable length oligonucleotide generation. In addition, our software is able to supply quality scores for each of the designed probes. In order to assess the relevance of these scores, we performed a real hybridization using a tiling array designed against the Trichoderma reesei fungus genome. We show that our scoring pipeline correlates with signal quality for 97.2% of all the designed probes, allowing for a posteriori comparisons between quality scores and signal intensities. This result is useful in discarding any bad scoring probes during the design step in order to get high-quality microarrays. Teolenn is available at http://transcriptome.ens.fr/teolenn/. PMID:20176570

  4. High-quality substrate for fluorescence enhancement using agarose-coated silica opal film.

    Science.gov (United States)

    Xu, Ming; Li, Juan; Sun, Liguo; Zhao, Yuanjin; Xie, Zhuoying; Lv, Linli; Zhao, Xiangwei; Xiao, Pengfeng; Hu, Jing; Lv, Mei; Gu, Zhongze

    2010-08-01

    To improve the sensitivity of fluorescence detection in biochip, a new kind of substrates was developed by agarose coating on silica opal film. In this study, silica opal film was fabricated on glass substrate using the vertical deposition technique. It can provide stronger fluorescence signals and thus improve the detection sensitivity. After coating with agarose, the hybrid film could provide a 3D support for immobilizing sample. Comparing with agarose-coated glass substrate, the agarose-coated opal substrates could selectively enhance particular fluorescence signals with high sensitivity when the stop band of the silica opal film in the agarose-coated opal substrate overlapped the fluorescence emission wavelength. A DNA hybridization experiment demonstrated that fluorescence intensity of special type of agarose-coated opal substrates was about four times that of agarose-coated glass substrate. These results indicate that the optimized agarose-coated opal substrate can be used for improving the sensitivity of fluorescence detection with high quality and selectivity.

  5. Establishment of Korea-Russia bilateral research collaboration for studies on biological effects of cosmic ray and space radiation

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Juwoon; Kim, Dongho; Choi, Jongil; Song, Beomseok; Kim, Jaekyung; Kang, Oilhyun; Lee, Yoonjong; Kim, Jinhong; Jo, Minho

    2011-04-15

    {Omicron} KAERI-IBMP joint workshop on countermeasure and application researches to space environments - Sharing of state-of-the-art researches on space radiobiology using bio-satellites (BION-M1, Photon-soil) and ISS module (Bio-risk) was conducted - Sharing and discussion of state-of-the-art researches on dosimetry of space radiation and its affect on organisms were conducted. {Omicron} Making a contract on KAERI-IBMP Joint Research using Bio-risk module - Contract on KAERI-IBMP Joint Research to evaluate effect of space environment (microgravity and space radiation) on fermentative fungi (Aspergillus oryzae), Algae (Nostoc sp.), and plant seeds (rice, Arabidopsis thaliana, Brachypodium distachyon) was made in November, 2010. {Omicron} Discussion on new Joint Researches on evaluation of space radiation on organisms - Final step on Bion-M projects in terms of evaluation of physiological changes of lactic acid bacteria consumed by Mouse - Discussing new joint research on evaluation of physiological changes of primate by space radiation {Omicron} Establishment and management of the practical working group to invite a branch office of the IBMP in Korea - The system and the working group to implement cooperating researches between KAERI-IBMP on space radiation were established.

  6. Establishment of Korea-Russia bilateral research collaboration for studies on biological effects of cosmic ray and space radiation

    International Nuclear Information System (INIS)

    Lee, Juwoon; Kim, Dongho; Choi, Jongil; Song, Beomseok; Kim, Jaekyung; Kang, Oilhyun; Lee, Yoonjong; Kim, Jinhong; Jo, Minho

    2011-04-01

    Ο KAERI-IBMP joint workshop on countermeasure and application researches to space environments - Sharing of state-of-the-art researches on space radiobiology using bio-satellites (BION-M1, Photon-soil) and ISS module (Bio-risk) was conducted - Sharing and discussion of state-of-the-art researches on dosimetry of space radiation and its affect on organisms were conducted. Ο Making a contract on KAERI-IBMP Joint Research using Bio-risk module - Contract on KAERI-IBMP Joint Research to evaluate effect of space environment (microgravity and space radiation) on fermentative fungi (Aspergillus oryzae), Algae (Nostoc sp.), and plant seeds (rice, Arabidopsis thaliana, Brachypodium distachyon) was made in November, 2010. Ο Discussion on new Joint Researches on evaluation of space radiation on organisms - Final step on Bion-M projects in terms of evaluation of physiological changes of lactic acid bacteria consumed by Mouse - Discussing new joint research on evaluation of physiological changes of primate by space radiation Ο Establishment and management of the practical working group to invite a branch office of the IBMP in Korea - The system and the working group to implement cooperating researches between KAERI-IBMP on space radiation were established

  7. Towards Establishing an Open Access Repository of Indian Publications in Astronomy -- a Case Study of Indian Institute of Astrophysics Repository

    Science.gov (United States)

    Birdie, C.; Vagiswari, A.

    2007-10-01

    The continued escalation of journal prices, and inadequate access to scholarly journals along with a consistent reduction in library resources and the advent of new technologies have all contributed to a change in the present scholarly communication. The initiative towards establishing Open Access communication has been advocated among scholars and researchers. An Institutional Archive for holding pre- and post-prints of articles written by academic and research staff increases the accessibility, visibility and impact of research output. The Indian Institute of Astrophysics (IIA) is one of the astronomical research institutes in India pioneering the Open Access movement. The institute has set up a pilot project to store the institute's publications in an institutional repository (IR). The library at IIA plays an important role in setting up this archive. While the authors and publishers are the key players in this endeavor, the role of librarians needs to be redefined in the present paradigm shift of publishing. When the Institutes decide to develop their own repositories, the skills and expertise of librarians are needed to design, develop, manage and maintain a successful repository. These and the knowledge of copyright issues relevant to the digital content of IRs are highlighted in this paper. This paper also discusses the various opportunities and tools available for librarians to learn the procedures and involve themselves in establishing their institutional repositories.

  8. Case Study: Strategy for the Establishment of the Centre for Nuclear Safety and Security in South Africa

    International Nuclear Information System (INIS)

    Nhleko, S.; Tyobeka, B.M.

    2016-01-01

    Full text: The establishment of a dedicated nuclear safety centre as part of nuclear industry infrastructure is a common practice among nuclear countries that is also recognized and recommended by the International Atomic Energy Agency (see, for instance, IAEA GSR Part 1). However, South Africa currently does not have such a centre. This paper presents a strategy that has been developed for the establishment of a nuclear safety centre that will support the nuclear knowledge management infrastructure of the National Nuclear Regulator of South Africa. After a brief introduction, the challenges faced by the Regulator are presented. Next, the minimum requirements for addressing the challenges are summarized by providing an outline of strategic objectives to be fulfilled. This is followed by the description of the strategy developed to fulfil the objectives, including key programmes that will be implemented. A qualitative evaluation of benefits that will result from the implementation of the strategy is also presented. Additional provisions which are required in the national legislation to facilitate successful implementation of the strategy are highlighted based on lessons learned from other regulators. Finally, lessons learned during the execution of this project are summarized in order to provide guidelines for similar projects. (author

  9. Establishment of intestinal microbiota during early life: a longitudinal, explorative study of a large cohort of Danish infants.

    Science.gov (United States)

    Bergström, Anders; Skov, Thomas Hjort; Bahl, Martin Iain; Roager, Henrik Munch; Christensen, Line Brinch; Ejlerskov, Katrine Tschentscher; Mølgaard, Christian; Michaelsen, Kim F; Licht, Tine Rask

    2014-05-01

    Fecal samples were obtained from a cohort of 330 healthy Danish infants at 9, 18, and 36 months after birth, enabling characterization of interbacterial relationships by use of quantitative PCR targeting 31 selected bacterial 16S rRNA gene targets representing different phylogenetic levels. Nutritional parameters and measures of growth and body composition were determined and investigated in relation to the observed development in microbiota composition. We found that significant changes in the gut microbiota occurred, particularly from age 9 to 18 months, when cessation of breastfeeding and introduction of a complementary feeding induce replacement of a microbiota characterized by lactobacilli, bifidobacteria, and Enterobacteriaceae with a microbiota dominated by Clostridium spp. and Bacteroides spp. Classification of samples by a proxy enterotype based on the relative levels of Bacteroides spp. and Prevotella spp. showed that enterotype establishment occurs between 9 and 36 months. Thirty percent of the individuals shifted enterotype between 18 and 36 months. The composition of the microbiota was most pronouncedly influenced by the time of cessation of breastfeeding. From 9 to 18 months, a positive correlation was observed between the increase in body mass index and the increase of the short-chain-fatty-acid-producing clostridia, the Clostridum leptum group, and Eubacterium hallii. Considering previously established positive associations between rapid infant weight gain, early breastfeeding discontinuation, and later-life obesity, the corresponding microbial findings seen here warrant attention.

  10. Promoting High Quality Teacher-Child Interactions: Examining the Role of Teachers' Depression, Perceptions of Children's Peer Relationships, and Contextual Factors

    Science.gov (United States)

    Granger, Kristen

    2017-01-01

    The overall goal of this dissertation was to examine teacher characteristics, teachers' beliefs, and contextual factors that may motivate teachers' decisions to engage in high quality teacher-child interactions. I use two complementary studies to meet this goal. These two studies provide insight into several aspects of early childhood teachers'…

  11. A study on the establishment of national regulatory framework for effective implementation of exemption or clearance concept

    International Nuclear Information System (INIS)

    Cheong, J.H.; Park, S.H.; Suk, T.W.

    1998-01-01

    The concepts of exemption and clearance have a lot of advantages in the aspects of effective use of limited resources, land, and optimization of regulatory works. The exact scopes and extent of the implementation of the concepts, however, can widely vary depending upon each country's own specific situations. In order to support the political decision-making on the practical implementation, a series of possible alternatives, general methodology for decision-making, and factors to be considered were proposed. Five primary categories and subsequent nineteen secondary categories were suggested and discussed, and four-step-approach was introduced in order to show the general guidelines for establishing an appropriate national regulatory framework. Though the specific procedure for each country to get to the practical implementation of the exemption and clearance concepts was not described, it is anticipated that the basic guidelines proposed in this paper can be used as a general reference. (author)

  12. Establishment of bases for joint study and cooperation on long-lived radionuclides transmutation between Korea and Russia

    International Nuclear Information System (INIS)

    Yoo, Jae Hyung; Lee, Byung Jik; Shim, Joon Bo; Choi, Chang Joo; Park, Won Seok; Song, Tae Young; Kim, Chang Kyu; Kil, Choong Sup

    2003-02-01

    The most important technical fields related to transmutation are partitioning of long-lived radionuclides and transmutation system to be used for converting them into short-lived or stable radionuclides. Technical cooperation between Korea and Russia is needed because Russia has an unequalled position in the fields of development of the fast reactors and pyrochemical processes around the world. The aim of this project is an establishment of bases for coordination on transmutation technology between Korea and Russia. State of the art of domestic and foreign countries upon partitioning of long-lived radionuclides, transmutation system and Gen IV development was summarized. Also, the 7th Korea-Russia joint coordination committee meeting and the 1st joint workshop were held as a result of this project. Technical fields and scheme on future cooperation between Korea and Russia were discussed and agreed in the course of the meetings

  13. Stainless steel fabrication for high quality requirements in the nuclear industry

    International Nuclear Information System (INIS)

    Wareing, A.J.

    1990-01-01

    In this paper the author explains the welding procedures and practices adopted within the nuclear industry to achieve the high quality and standards of welds required. The changeover to mechanised welding, orbital TIG welding and synergic MIG welding, has resulted in consistent achievement of high quality standards as well as optimising the productivity. However, the use of mechanised welding machines does require the welder operating them to be fully trained and qualified. The formally organised training courses are described and the cost savings and production rates achieved by utilising the mechanised method are discussed. (author)

  14. If Parents Establish a No-Smoking Agreement with Their Offspring, Does This Prevent Adolescents from Smoking? Findings from Three Dutch Studies

    Science.gov (United States)

    den Exter Blokland, Endy A. W.; Engels, Rutger C.; Harakeh, Zeena; Hale, William W., III.; Meeus, Wim

    2009-01-01

    Data from three studies were used to investigate whether the establishment of a no-smoking agreement is related to lower odds of adolescent smoking. The prevalence of a no-smoking agreement was first explored by using a national sample involving 4,501 Dutch adolescents. Second, data from a longitudinal study among 595 early adolescents and their…

  15. FY 1993 annual report. Survey and study on establishment of databases for body functions; 1993 nendo shintai kino database no kochiku ni kansuru chosa kenkyu hokokusho

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-03-01

    As part of the health/welfare-related information collection, analysis and information service project, establishment of the databases is surveyed and studied for human life technology and body functions of the aged in the aging society. The survey/study on establishment of the human life technology for the aged covers concept of human life technology, systems of the databases for human life technology, and techniques for the database systems. The case study on the human life technology databases for the aged takes up everyday life behaviors of the aged as the models, and analyzes human and life characteristics in everyday life, to clarify the human characteristic, human performance and human life technology design data to be stored in the databases. The validity of the method developed by this project is tested for their behaviors, such as bathing and outgoing. For establishment of the databases for body functions of the aged, literature surveys and interviews are conducted for the technological trends. (NEDO)

  16. Hall effect measurements of high-quality M n3CuN thin films and the electronic structure

    Science.gov (United States)

    Matsumoto, Toshiki; Hatano, Takafumi; Urata, Takahiro; Iida, Kazumasa; Takenaka, Koshi; Ikuta, Hiroshi

    2017-11-01

    The physical properties of M n3CuN were studied using thin films. We found that an annealing process was very effective to improve the film quality, the key of which was the use of Ti that prevented the formation of oxide impurities. Using these high-quality thin films, we found strong strain dependence for the ferromagnetic transition temperature (TC) and a sign change of the Hall coefficient at TC. The analysis of Hall coefficient data revealed a sizable decrease of hole concentration and a large increase of electron mobility below TC, which is discussed in relation to the electronic structure of this material.

  17. High quality draft genome sequence of the moderately halophilic bacterium Pontibacillus yanchengensis Y32(T) and comparison among Pontibacillus genomes.

    Science.gov (United States)

    Huang, Jing; Qiao, Zi Xu; Tang, Jing Wei; Wang, Gejiao

    2015-01-01

    Pontibacillus yanchengensis Y32(T) is an aerobic, motile, Gram-positive, endospore-forming, and moderately halophilic bacterium isolated from a salt field. In this study, we describe the features of P. yanchengensis strain Y32(T) together with a comparison with other four Pontibacillus genomes. The 4,281,464 bp high-quality-draft genome of strain Y32(T) is arranged into 153 contigs containing 3,965 protein-coding genes and 77 RNA encoding genes. The genome of strain Y32(T) possesses many genes related to its halophilic character, flagellar assembly and chemotaxis to support its survival in a salt-rich environment.

  18. "Liquid-liquid-solid"-type superoleophobic surfaces to pattern polymeric semiconductors towards high-quality organic field-effect transistors.

    Science.gov (United States)

    Wu, Yuchen; Su, Bin; Jiang, Lei; Heeger, Alan J

    2013-12-03

    Precisely aligned organic-liquid-soluble semiconductor microwire arrays have been fabricated by "liquid-liquid-solid" type superoleophobic surfaces directed fluid drying. Aligned organic 1D micro-architectures can be built as high-quality organic field-effect transistors with high mobilities of >10 cm(2) ·V(-1) ·s(-1) and current on/off ratio of more than 10(6) . All these studies will boost the development of 1D microstructures of organic semiconductor materials for potential application in organic electronics. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  19. A prospective multiple case study of the impact of emerging scientific evidence on established colorectal cancer screening programs: a study protocol.

    Science.gov (United States)

    Geddie, Hannah; Dobrow, Mark J; Hoch, Jeffrey S; Rabeneck, Linda

    2012-06-01

    Health-policy decision making is a complex and dynamic process, for which strong evidentiary support is required. This includes scientifically produced research, as well as information that relates to the context in which the decision takes place. Unlike scientific evidence, this "contextual evidence" is highly variable and often includes information that is not scientifically produced, drawn from sources such as political judgement, program management experience and knowledge, or public values. As the policy decision-making process is variable and difficult to evaluate, it is often unclear how this heterogeneous evidence is identified and incorporated into "evidence-based policy" decisions. Population-based colorectal cancer screening poses an ideal context in which to examine these issues. In Canada, colorectal cancer screening programs have been established in several provinces over the past five years, based on the fecal occult blood test (FOBT) or the fecal immunochemical test. However, as these programs develop, new scientific evidence for screening continues to emerge. Recently published randomized controlled trials suggest that the use of flexible sigmoidoscopy for population-based screening may pose a greater reduction in mortality than the FOBT. This raises the important question of how policy makers will address this evidence, given that screening programs are being established or are already in place. This study will examine these issues prospectively and will focus on how policy makers monitor emerging scientific evidence and how both scientific and contextual evidence are identified and applied for decisions about health system improvement. This study will employ a prospective multiple case study design, involving participants from Ontario, Alberta, Manitoba, Nova Scotia, and Quebec. In each province, data will be collected via document analysis and key informant interviews. Documents will include policy briefs, reports, meeting minutes, media

  20. Experimental study of essential hypertension related to neurovascular compression established by fixation of balloon at the left lateral medulla

    International Nuclear Information System (INIS)

    Shen Jialin; Xu Jianrong; Luo Qizhong; Zhang Xiaohua; Li Shanquan; Chen Kemin

    2002-01-01

    Objective: To explore the possible mechanisms of neurogenic hypertension. Methods: With the guide of modern imaging, the hypertensive animal model of pulsatile neurovascular compression was established by fixation of balloon at the entry zone of the ninth and tenth cranial nerves of the left ventrolateral medulla oblongata. Blood pressure and heart rate data were collected at preoperation and one hour, 2 weeks, 4 weeks, and 6 weeks of postoperation. Results: The results showed that SBP at postoperation rose by 27.3%, 26.1%, 25.4% and 27.4%, respectively; DBP rose by 18.8%, 20.8%, 20.0% and 20.2%, respectively; MAP rose by 24.2%, 24.1%, 23.2% and 24.8%, respectively; HR rose by 34.9%, 26.7%, 26.9% and 26.1% respectively. Statistically, SBP, DAP, MAP and HR of postoperation significantly increased compared with that of preoperation in hypertension group (F = 9.044, 12,679, 11.306, 16.536, P 0.05). Conclusion: Essential hypertension may by caused by neurovascular compression of ninth and tenth cranial nerves of the left ventrolateral medulla oblongata at the REZ

  1. Atomic Weapons Establishment Bill

    International Nuclear Information System (INIS)

    Clark, Alan; Dalyell, Tam; Haynes, Frank

    1990-01-01

    The Bill debated concerns the government's proposal for the future organisations of the atomic weapons establishment in the United Kingdom. The proposals arise from a full review carried out in 1989 and include points raised by the Select Committee on the Trident programme. Studies of productivity, pay and conditions, information systems and long term manufacturing strategy have been started to enable recommendations of the reorganisation of the establishments to be made. The details of the Bill were debated for just over two hours. The debate is reported verbatim. The main issues were over the principle of contractorisation, possible staff redundancies, conditions of employment, safety and security. The proposal that the Bill be read a second time was carried. (UK)

  2. Producing high-quality negatives from ERTS black-and-white transparancies

    Science.gov (United States)

    Richard J. Myhre

    1973-01-01

    A method has been devised for producing high-quality black-and-white negatives quickly and efficiently from dense transparencies orgininating from Earth Resources Technology Satellite imagery. Transparencies are evaluated on a standard light source to determine exposure and processing information needed for making negatives. A “System ASA Rating” was developed by...

  3. High quality ion channels recordings on an injection molded polymer chip

    DEFF Research Database (Denmark)

    Tanzi, Simone

    In this thesis we demonstrate high quality recordings of the ion channel activity across the cell membrane in a biological cell by employing the so called patch clamping technique on an injection molded polymer microfluidic device. Such recordings are traditionally made using glass micropipettes,...

  4. High-quality bulk hybrid perovskite single crystals within minutes by inverse temperature crystallization

    KAUST Repository

    Saidaminov, Makhsud I.; Abdelhady, Ahmed L.; Banavoth, Murali; Alarousu, Erkki; Burlakov, Victor M.; Peng, Wei; Dursun, Ibrahim; Wang, Lingfei; He, Yao; Maculan, Giacomo; Goriely, Alain; Wu, Tao; Mohammed, Omar F.; Bakr, Osman

    2015-01-01

    Single crystals of methylammonium lead trihalide perovskites (MAPbX3; MA=CH3NH3+, X=Br− or I−) have shown remarkably low trap density and charge transport properties; however, growth of such high-quality semiconductors is a time-consuming process

  5. Animated Cell Biology: A Quick and Easy Method for Making Effective, High-Quality Teaching Animations

    Science.gov (United States)

    O'Day, Danton H.

    2006-01-01

    There is accumulating evidence that animations aid learning of dynamic concepts in cell biology. However, existing animation packages are expensive and difficult to learn, and the subsequent production of even short animations can take weeks to months. Here I outline the principles and sequence of steps for producing high-quality PowerPoint…

  6. High quality factor GaAs microcavity with buried bullseye defects

    DEFF Research Database (Denmark)

    Winkler, K.; Gregersen, Niels; Hayrynen, T.

    2018-01-01

    The development of high quality factor solid-state microcavities with low mode volumes has paved the way towards on-chip cavity quantum electrodynamics experiments and the development of high-performance nanophotonic devices. Here, we report on the implementation of a new kind of solid...

  7. A safe inexpensive method to isolate high quality plant and fungal ...

    African Journals Online (AJOL)

    STORAGESEVER

    2008-08-18

    Aug 18, 2008 ... quality DNA from plant and fungal species. This method uses potassium acetate to remove proteins and polysaccharides in an SDS extraction buffer. Further DNA purification is achieved using a low salt. CTAB treatment. This SDS/CTAB protocol was used to isolate high quality genomic DNA subject to.

  8. 10 Principles for Building a High-Quality System of Assessments

    Science.gov (United States)

    Jobs for the Future, 2018

    2018-01-01

    Many states and districts are working toward developing and implementing high-quality systems that align assessments with each other, and to college and career readiness, and a comprehensive set of higher-order thinking skills. In order to support states, districts, and communities in this, the following 10 principles as guidance and common…

  9. Access, Participation, and Supports: The Defining Features of High-Quality Inclusion

    Science.gov (United States)

    Buysse, Virginia

    2011-01-01

    This article describes current knowledge about early childhood inclusion, summarizing research and the DEC/NAEYC joint position statement on inclusion. The article also describes effective or promising educational practices that promote access, participation, and supports--the defining features of high-quality inclusion. Future efforts to improve…

  10. High quality data: An evaluation of AIM data quality and data quality procedures

    Science.gov (United States)

    The goal of every monitoring program is to collect high-quality data which can then be used to provide information to decision makers. The Bureau of Land Management (BLM) Assessment, Inventory, and Monitoring (AIM) program is one such data set which provides rangeland status, condition, and trend in...

  11. Dare to share? How people share high-quality knowledge in online communities

    NARCIS (Netherlands)

    Rotundo, Enrico; Blank, M.; Moser, C.; Leopold, H.

    The Internet has fundamentally changed how work gets done in the 21st century. For example, people increasingly spend time on the Internet where they share and develop knowledge in online communities. Yet, little is known about how high-quality knowledge comes about in these communities. This is

  12. Prevalence of Periodontitis in Patients with Established Rheumatoid Arthritis: A Swedish Population Based Case-Control Study

    Science.gov (United States)

    Eriksson, Kaja; Nise, Lena; Kats, Anna; Luttropp, Elin; Catrina, Anca Irinel; Askling, Johan; Jansson, Leif; Alfredsson, Lars; Klareskog, Lars; Lundberg, Karin; Yucel-Lindberg, Tülay

    2016-01-01

    Introduction The possible hypothesis of a link between periodontitis and rheumatoid arthritis (RA), specifically anti-citrullinated protein antibody (ACPA) positive RA, prompted us to investigate the prevalence of periodontitis in the Swedish Epidemiological Investigation of RA (EIRA), a well-characterised population-based RA case-control cohort. Methods Periodontal status of 2,740 RA cases and 3,942 matched controls was retrieved through linking EIRA with the National Dental Health Registry (DHR), where dental diagnostic- and treatment codes on the adult Swedish population have been registered. Dental records from 100 cases and controls were reviewed to validate the periodontal diagnostic codes in DHR. Results The reviewed dental records confirmed 90% of the periodontitis diagnoses in DHR among RA cases, and 88% among controls. We found the positive predictive value of periodontitis diagnoses in the DHR to be 89% (95% CI 78 to 95%) with a sensitivity of 77% (95% CI: 65 to 86%). In total, 86% of EIRA participants were identified in DHR. The risk for periodontitis increased by age and current smoking status in both cases as well as controls. No significant differences in prevalence of periodontal disease in terms of gingivitis, periodontitis, peri-implantitis or increased risk for periodontitis or peri-implantitis were observed between RA cases and controls. In addition, there was no difference on the basis of seropositivity, ACPA or rheumatoid factor (RF), among patients with RA. Conclusions Our data verify that smoking and ageing are risk factors for periodontitis, both in RA and controls. We found no evidence of an increased prevalence of periodontitis in patients with established RA compared to healthy controls, and no differences based on ACPA or RF status among RA subjects. PMID:27203435

  13. Establishment of an Arabidopsis callus system to study the interrelations of biosynthesis, degradation and accumulation of carotenoids

    Science.gov (United States)

    Schaub, Patrick; Rodriguez-Franco, Marta; Cazzonelli, Christopher Ian; Álvarez, Daniel; Wüst, Florian

    2018-01-01

    The net amounts of carotenoids accumulating in plant tissues are determined by the rates of biosynthesis and degradation. While biosynthesis is rate-limited by the activity of PHYTOENE SYNTHASE (PSY), carotenoid losses are caused by catabolic enzymatic and non-enzymatic degradation. We established a system based on non-green Arabidopsis callus which allowed investigating major determinants for high steady-state levels of β-carotene. Wild-type callus development was characterized by strong carotenoid degradation which was only marginally caused by the activity of carotenoid cleavage oxygenases. In contrast, carotenoid degradation occurred mostly non-enzymatically and selectively affected carotenoids in a molecule-dependent manner. Using carotenogenic pathway mutants, we found that linear carotenes such as phytoene, phytofluene and pro-lycopene resisted degradation and accumulated while β-carotene was highly susceptible towards degradation. Moderately increased pathway activity through PSY overexpression was compensated by degradation revealing no net increase in β-carotene. However, higher pathway activities outcompeted carotenoid degradation and efficiently increased steady-state β-carotene amounts to up to 500 μg g-1 dry mass. Furthermore, we identified oxidative β-carotene degradation products which correlated with pathway activities, yielding β-apocarotenals of different chain length and various apocarotene-dialdehydes. The latter included methylglyoxal and glyoxal as putative oxidative end products suggesting a potential recovery of carotenoid-derived carbon for primary metabolic pathways. Moreover, we investigated the site of β-carotene sequestration by co-localization experiments which revealed that β-carotene accumulated as intra-plastid crystals which was confirmed by electron microscopy with carotenoid-accumulating roots. The results are discussed in the context of using the non-green calli carotenoid assay system for approaches targeting high

  14. [Establishment of Primary Adult MDS Nested Case-Control Study Cohort and Study of Risk Factors Associated with MDS Evolution to Leukemia].

    Science.gov (United States)

    Ma, Yan; Chen, Bo-Bin; Wang, Xiao-Qin; Xu, Xiao-Ping; Lin, Guo-Wei

    2015-12-01

    To establish a nested case-control study cohort in myelodysplastic syndrome (MDS) patients and investigate the clinical characteristics, WHO subtype and risk factors associated with MDS evolution to leukemia of this cohort. All patients, ≥18 years of age, provided by 24 Shanghai hospitals with initial clinical findings consistent with a hematopoietic abnormality between June 2003 and April 2007, were the candidates for inclusion in this study. The blood and bone marrow samples of every patient should be provided at baseline. Diagnosis was made by incorporating morphologic, immunophenotypic, cytogenetic and molecular features according to WHO classification criteria. Cytogenetic analysis was performed using conventional G-banding karyotyping and fluorescence in situ hybridization (FISH) techniques. Cumulative risk of evolution was estimated by Kaplan-Meier method. Prognostic factors were evaluated by univariate Log-rank method and multivariate Cox proportional hazard models. A total of 435 patients were diagnosed as MDS. The median age of MDS onset was 58(18-90) years, with 248 male patients and 187 female patients (male: female 1.33: 1). The percentage of cases with refractory cytopenia with multilineage dysplasia (RCMD) was the highest (65.5%), while that of refraetory anemia (RA) (2.3%), refractory anenia with ring sideroblast (RARS) (1.1%) and 5q-syndrome (0.5%) was lower. Trisomy 8 (+8) was the most common chromosome abnormalities (71 cases, 12.7%). The mean follow-up time was 20.3 (4.2-57.1) months. Cases were patients with evolution by the end of follow-up, while controls were patients without evolution by that time. Case group included 41 patients and control group included 342 patients. Univariate analysis showed that the age, sex, WHO subtype, WBC count, absolute neutrophil count (ANC), IPSS cytogenetic subgroup, IPSS group and bone marrow blast percentage were significant risk factors for leukemia-free survival (LFS). Multivariate analysis of COX model

  15. Long-Term Physical Functioning and Its Association With Somatic Comorbidity and Comorbid Depression in Patients With Established Rheumatoid Arthritis: A Longitudinal Study

    NARCIS (Netherlands)

    van den Hoek, J.; Roorda, L.D.; Boshuizen, H.C.; van Hees, J.; Rupp, I.; Tijhuis, G.J.; Dekker, J.; van den Bos, G.A.M.

    2013-01-01

    Objective To describe long-term physical functioning and its association with somatic comorbidity and comorbid depression in patients with established rheumatoid arthritis (RA). Methods Longitudinal data over a period of 11 years were collected from 882 patients with RA at study inclusion.

  16. Long-Term Physical Functioning and Its Association With Somatic Comorbidity and Comorbid Depression in Patients With Established Rheumatoid Arthritis: A Longitudinal Study

    NARCIS (Netherlands)

    Hoek, J.; Roorda, L.D.; Boshuizen, H.C.; Hees, van J.; Rupp, I.; Tijhuis, G.J.; Dekker, J.; Bos, van den G.A.M.

    2013-01-01

    ObjectiveTo describe long-term physical functioning and its association with somatic comorbidity and comorbid depression in patients with established rheumatoid arthritis (RA). MethodsLongitudinal data over a period of 11 years were collected from 882 patients with RA at study inclusion.

  17. Evaluation of new and established age-related macular degeneration susceptibility genes in the Women's Health Initiative Sight Exam (WHI-SE) Study

    Science.gov (United States)

    To assess whether established and newly reported genetic variants, independent of known lifestyle factors, are associated with the risk of age-related macular degeneration (AMD) among women participating in the Women's Health Initiative Sight Exam (WHI-SE) Genetic Ancillary Study. This is a multice...

  18. Establishment, maintenance and in vitro and in vivo applications of primary human glioblastoma multiforme (GBM) xenograft models for translational biology studies and drug discovery.

    Science.gov (United States)

    Carlson, Brett L; Pokorny, Jenny L; Schroeder, Mark A; Sarkaria, Jann N

    2011-03-01

    Development of clinically relevant tumor model systems for glioblastoma multiforme (GBM) is important for advancement of basic and translational biology. One model that has gained wide acceptance in the neuro-oncology community is the primary xenograft model. This model entails the engraftment of patient tumor specimens into the flank of nude mice and subsequent serial passage of these tumors in the flank of mice. These tumors are then used to establish short-term explant cultures or intracranial xenografts. This unit describes detailed procedures for establishment, maintenance, and utilization of a primary GBM xenograft panel for the purpose of using them as tumor models for basic or translational studies.

  19. Current trends in outcome studies for children with hearing loss and the need to establish a comprehensive framework of measuring outcomes in children with hearing loss in China

    Directory of Open Access Journals (Sweden)

    Xueman Liu

    2016-06-01

    Full Text Available Since the 1970s, outcome studies for children with hearing loss expanded from focusing on assessing auditory awareness and speech perception skills to evaluating language and speech development. Since the early 2000s, the multi-center large scale research systematically studied outcomes in the areas of auditory awareness, speech-perception, language development, speech development, educational achievements, cognitive development, and psychosocial development. These studies advocated the establishment of baseline and regular follow-up evaluations with a comprehensive framework centered on language development. Recent research interests also include understanding the vast differences in outcomes for children with hearing loss, understanding the relationships between neurocognitive development and language acquisition in children with hearing loss, and using outcome studies to guide evidence-based clinical practice. After the establishment of standardized Mandarin language assessments, outcomes research in Mainland China has the potential to expand beyond auditory awareness and speech perception studies.

  20. Methods of cutting ponderosa pine in the Southwest - Establishment report: Even-aged yield study, Plot 11

    Science.gov (United States)

    Gilbert H. Schubert

    1963-01-01

    The objectie of the study is to obtain information on the growth and yield of even-aged stands of different stocking levels. The plot will also serve as the start of a detailed growing stock study for the ponderosa pine region.

  1. Gender disparities in high-quality research revealed by Nature Index journals.

    Science.gov (United States)

    Bendels, Michael H K; Müller, Ruth; Brueggmann, Doerthe; Groneberg, David A

    2018-01-01

    The present study aims to elucidate the state of gender equality in high-quality research by analyzing the representation of female authorships in the last decade (from 2008 to 2016). Based on the Gendermetrics platform, 293,557 research articles from 54 journals listed in the Nature Index were considered covering the categories Life Science, Multidisciplinary, Earth & Environmental and Chemistry. The core method was the combined analysis of the proportion of female authorships and the female-to-male odds ratio for first, co- and last authorships. The distribution of prestigious authorships was measured by the Prestige Index. 29.8% of all authorships and 33.1% of the first, 31.8% of the co- and 18.1% of the last authorships were held by women. The corresponding female-to-male odds ratio is 1.19 (CI: 1.18-1.20) for first, 1.35 (CI: 1.34-1.36) for co- and 0.47 (CI: 0.46-0.48) for last authorships. Women are underrepresented at prestigious authorships compared to men (Prestige Index = -0.42). The underrepresentation accentuates in highly competitive articles attracting the highest citation rates, namely, articles with many authors and articles that were published in highest-impact journals. More specifically, a large negative correlation between the 5-Year-Impact-Factor of a journal and the female representation at prestigious authorships was revealed (r(52) = -.63, P authorships) and are underrepresented at productivity levels of more than 2 articles per author. Articles with female key authors are less frequently cited than articles with male key authors. The gender-specific differences in citation rates increase the more authors contribute to an article. Distinct differences at the journal, journal category, continent and country level were revealed. The prognosis for the next decades forecast a very slow harmonization of authorships odds between the two genders.

  2. High quality superconducting titanium nitride thin film growth using infrared pulsed laser deposition

    Science.gov (United States)

    Torgovkin, A.; Chaudhuri, S.; Ruhtinas, A.; Lahtinen, M.; Sajavaara, T.; Maasilta, I. J.

    2018-05-01

    Superconducting titanium nitride (TiN) thin films were deposited on magnesium oxide, sapphire and silicon nitride substrates at 700 °C, using a pulsed laser deposition (PLD) technique, where infrared (1064 nm) pulses from a solid-state laser were used for the ablation from a titanium target in a nitrogen atmosphere. Structural studies performed with x-ray diffraction showed the best epitaxial crystallinity for films deposited on MgO. In the best films, superconducting transition temperatures, T C, as high as 4.8 K were observed, higher than in most previous superconducting TiN thin films deposited with reactive sputtering. A room temperature resistivity down to ∼17 μΩ cm and residual resistivity ratio up to 3 were observed in the best films, approaching reported single crystal film values, demonstrating that PLD is a good alternative to reactive sputtering for superconducting TiN film deposition. For less than ideal samples, the suppression of the film properties were correlated mostly with the unintended incorporation of oxygen (5–10 at%) in the film, and for high oxygen content films, vacuum annealing was also shown to increase the T C. On the other hand, superconducting properties were surprisingly insensitive to the nitrogen content, with high quality films achieved even in the highly nitrogen rich, Ti:N = 40/60 limit. Measures to limit oxygen exposure during deposition must be taken to guarantee the best superconducting film properties, a fact that needs to be taken into account with other deposition methods, as well.

  3. Two efficient methods for isolation of high-quality genomic DNA from entomopathogenic fungi.

    Science.gov (United States)

    Serna-Domínguez, María G; Andrade-Michel, Gilda Y; Arredondo-Bernal, Hugo C; Gallou, Adrien

    2018-03-27

    Conventional and commercial methods for isolation of nucleic acids are available for fungal samples including entomopathogenic fungi (EPF). However, there is not a unique optimal method for all organisms. The cell wall structure and the wide range of secondary metabolites of EPF can broadly interfere with the efficiency of the DNA extraction protocol. This study compares three commercial protocols: DNeasy® Plant Mini Kit (Qiagen), Wizard® Genomic DNA Purification Kit (Promega), and Axygen™ Multisource Genomic DNA Miniprep Kit (Axygen) and three conventional methods based on different buffers: SDS, CTAB/PVPP, and CTAB/β-mercaptoethanol versus three cell lysis procedures: liquid nitrogen homogenization and two bead-beating materials (i.e., tungsten-carbide and stainless-steel) for four representative species of EPF (i.e., Beauveria bassiana, Hirsutella citriformis, Isaria javanica, and Metarhizium anisopliae). Liquid nitrogen homogenization combined with DNeasy® Plant Mini Kit (i.e., QN) or SDS buffer (i.e., SN) significantly improved the yield with a good purity (~1.8) and high integrity (>20,000 bp) of genomic DNA in contrast with other methods, also, these results were better when compared with the two bead-beating materials. The purified DNA was evaluated by PCR-based techniques: amplification of translation elongation factor 1-α (TEF) and two highly sensitive molecular markers (i.e., ISSR and AFLP) with reliable and reproducible results. Despite a variation in yield, purity, and integrity of extracted DNA across the four species of EPF with the different DNA extraction methods, the SN and QN protocols maintained a high-quality of DNA which is required for downstream molecular applications. Copyright © 2018 Elsevier B.V. All rights reserved.

  4. Convergent Polishing: A Simple, Rapid, Full Aperture Polishing Process of High Quality Optical Flats & Spheres

    Science.gov (United States)

    Suratwala, Tayyab; Steele, Rusty; Feit, Michael; Dylla-Spears, Rebecca; Desjardin, Richard; Mason, Dan; Wong, Lana; Geraghty, Paul; Miller, Phil; Shen, Nan

    2014-01-01

    Convergent Polishing is a novel polishing system and method for finishing flat and spherical glass optics in which a workpiece, independent of its initial shape (i.e., surface figure), will converge to final surface figure with excellent surface quality under a fixed, unchanging set of polishing parameters in a single polishing iteration. In contrast, conventional full aperture polishing methods require multiple, often long, iterative cycles involving polishing, metrology and process changes to achieve the desired surface figure. The Convergent Polishing process is based on the concept of workpiece-lap height mismatch resulting in pressure differential that decreases with removal and results in the workpiece converging to the shape of the lap. The successful implementation of the Convergent Polishing process is a result of the combination of a number of technologies to remove all sources of non-uniform spatial material removal (except for workpiece-lap mismatch) for surface figure convergence and to reduce the number of rogue particles in the system for low scratch densities and low roughness. The Convergent Polishing process has been demonstrated for the fabrication of both flats and spheres of various shapes, sizes, and aspect ratios on various glass materials. The practical impact is that high quality optical components can be fabricated more rapidly, more repeatedly, with less metrology, and with less labor, resulting in lower unit costs. In this study, the Convergent Polishing protocol is specifically described for fabricating 26.5 cm square fused silica flats from a fine ground surface to a polished ~λ/2 surface figure after polishing 4 hr per surface on a 81 cm diameter polisher. PMID:25489745

  5. A Study on the Establishment of Radiation Dose Estimation Procedure for Accumulated Radioactive Ions for RAON ISOL System

    Directory of Open Access Journals (Sweden)

    KIM Do Hyun

    2017-01-01

    Full Text Available For purposes of various experiments, RAON heavy ion accelerator facility has been designed in Korea. ISOL is one system of RAON accelerators to generate and separate rare isotopes. Radioactive ions generated from target-proton reactions are separated and accumulated at separation devices. The accumulated isotopes release the gamma radiations; therefore, the radiation safety must be clearly estimated. In this study, a process to evaluate radiations from the accumulated ions was proposed by modifying FISPACT code. The proposed process was validated by comparing a solution of single element decay problem. Using the process, a preliminary study for radiation doses were performed in a virtual separation devise.

  6. Establishment and optimization of NMR-based cell metabonomics study protocols for neonatal Sprague-Dawley rat cardiomyocytes.

    Science.gov (United States)

    Zhang, Ming; Sun, Bo; Zhang, Qi; Gao, Rong; Liu, Qiao; Dong, Fangting; Fang, Haiqin; Peng, Shuangqing; Li, Famei; Yan, Xianzhong

    2017-01-15

    A quenching, harvesting, and extraction protocol was optimized for cardiomyocytes NMR metabonomics analysis in this study. Trypsin treatment and direct scraping cells in acetonitrile were compared for sample harvesting. The results showed trypsin treatment cause normalized concentration increasing of phosphocholine and metabolites leakage, since the trypsin-induced membrane broken and long term harvesting procedures. Then the intracellular metabolite extraction efficiency of methanol and acetonitrile were compared. As a result, washing twice with phosphate buffer, direct scraping cells and extracting with acetonitrile were chosen to prepare cardiomyocytes extracts samples for metabonomics studies. This optimized protocol is rapid, effective, and exhibits greater metabolite retention. Copyright © 2016 Elsevier Inc. All rights reserved.

  7. 'Welzijn op Recept' (Social Prescribing): a helping hand in re-establishing social contacts - an explorative qualitative study.

    Science.gov (United States)

    Heijnders, Miriam L; Meijs, J J

    2018-05-01

    'Welzijn op Recept' is an intervention in which primary care providers refer patients with psychosocial problems to a community well-being organisation. Welzijn op Recept has been helping participants in the town of Nieuwegein, the Netherlands for more than three years. An impact study was carried out from September to December 2014. The qualitative study aimed to determine what happens in the chain of the social prescription and what changes the participant experiences in terms of social participation. The participants in this study were selected by the well-being coaches. A total of 10 semi-structured in-depth interviews were conducted. This study has shown that the participants had confidence in their referral to the community well-being organisation. The well-being coaches constitute a link between primary care providers, patients and the community well-being organisation. Participants have explicitly indicated that they experienced an increase in their own strength, self-confidence, self-reliance and the number of social contacts, and stated that they are experiencing better health. A point of special interest in the current programme is the planning of structured follow-up interviews after starting up an activity.

  8. Establishing oral health promoting behaviours in children – parents’ views on barriers, facilitators and professional support: a qualitative study

    NARCIS (Netherlands)

    Duijster, D.; Jong-Lenters, M. de; Verrips, E.; Loveren, C. van

    2015-01-01

    Background The prevention of childhood dental caries relies on adherence to key behaviours, including twice daily tooth brushing with fluoride toothpaste and reducing the consumption of sugary foods and drinks. The aim of this qualitative study was to explore parents’ perceptions of barriers and

  9. Establishing oral health promoting behaviours in children: parents' views on barriers, facilitators and professional support: a qualitative study

    NARCIS (Netherlands)

    Duijster, D.; de Jong-Lenters, M.; Verrips, E.; van Loveren, C.

    2015-01-01

    Background The prevention of childhood dental caries relies on adherence to key behaviours, including twice daily tooth brushing with fluoride toothpaste and reducing the consumption of sugary foods and drinks. The aim of this qualitative study was to explore parents’ perceptions of barriers and

  10. Using Storytelling to Establish Justice: A Narrative Study on the Efficacy of Teaching Police Recruits Individual Rights through Storytelling

    Science.gov (United States)

    Sautner, Kerry

    2017-01-01

    This study explored the narrative of new Philadelphia Police recruits' experiences within a training program that used storytelling techniques to positively influence their knowledge and assumptions about social justice and fairness. Prior research has suggested that storytelling can be an effective way to engage learners in understanding…

  11. Establishment of Risk based microbiological criteria in the Nordic countries: A case study on Campylobacter in broiler meat

    DEFF Research Database (Denmark)

    Nauta, Maarten

    Microbiological criteria (MCs) offer a practical tool for food safety control and they are currently under discussion internationally. To meet the present scientific standards, there is an increasing demand for so- called “risk based” microbiological criteria that are based on risk assessment....... In this project we studied the potentials for setting risk based microbiological criteria on Campylobacter in chicken meat by studying the potential impact that specific microbiological criteria would have in different Nordic countries. This is done on the basis of different data sets that have been collected...... based microbiological criteria, the “case-by-case” risk assessment methodology is used (Christensen et al 2013) and its impact is analysed on the basis of the same data sets. In both approaches the same risk assessment model for Campylobacter in broiler meat is used. The difference between...

  12. A Study on establishing Top-Down model - development of Global CGE model for Kyoto mechanism analysis

    Energy Technology Data Exchange (ETDEWEB)

    Cho, Gyeong Lyeong [Korea Energy Economics Institute, Euiwang (Korea)

    1999-07-01

    In Korea, it is true that studies on the Convention on Climate Change is behind compared with the developed countries. As a result, a clear goal on negotiation and a reasonable alternative to persuade other countries were not prepared and a negative and passive attitude of negotiation was showed when entering into negotiations with other countries. However, fortunately, the Convention on Climate Change is not completely reached an agreement. It means that there still remains time to contrive for terms favorable to Korea. To do this, a precise negotiating strategy should be prepared based on a reasonable and systematic study and with diplomatic negotiating power to assist it. Also, it should prepare for a next stage after the negotiation through the analyses of several scenarios. Developing a model for a simulation analysis is absolutely needed to set a more systematic and reasonable negotiation strategy for the Convention on Climate Change. (author). 32 refs., 14 fig., 36 tabs.

  13. Establishing oral health promoting behaviours in children ? parents? views on barriers, facilitators and professional support: a qualitative study

    OpenAIRE

    Duijster, Denise; de Jong-Lenters, Maddelon; Verrips, Erik; van Loveren, Cor

    2015-01-01

    Background The prevention of childhood dental caries relies on adherence to key behaviours, including twice daily tooth brushing with fluoride toothpaste and reducing the consumption of sugary foods and drinks. The aim of this qualitative study was to explore parents’ perceptions of barriers and facilitators that influence these oral health behaviours in children. A further objective was to explore parents’ views on limitations and opportunities for professional support to promote children’s ...

  14. Synthesis of high quality single-walled carbon nanotubes via a catalytic layer reinforced by self-assembled monolayers

    International Nuclear Information System (INIS)

    Adhikari, Prashanta Dhoj; Song, Wooseok; Cha, Myoung-Jun; Park, Chong-Yun

    2013-01-01

    This work reports the synthesis of high quality single-walled carbon nanotubes (SWCNT) using a catalytic layer reinforced by self-assembled monolayers (SAM). Amine-SAM was introduced on a SiO 2 /Si substrate and then an iron nanoparticles solution was dropped on the substrate by spin-coating. This catalytic template was used to grow carbon nanotubes by chemical vapor deposition and the synthesized SWCNT were observed to be prominent, based on the size distribution. Highly dense SWCNT with a diameter of about 1.1-1.2 nm were produced at 800-850 °C. Moreover, the diameter distribution of the SWCNT was more selective at a growth temperature of 900 °C. These findings provide important insights for a SAM support layer that can play the role as a restriction for the agglomeration of iron catalyst and is promising for the synthesis of high quality SWCNT. - Highlights: • Fe nanoparticles on self-assembled monolayers (SAM) containing template is underlined. • Its catalytic behavior to synthesis single-walled carbon nanotubes is studied. • The role of SAM on catalytic template is explored

  15. Economic production and processing of agricultural fibre plants for high quality applications in automotive, building and furniture industry

    Energy Technology Data Exchange (ETDEWEB)

    Pecenka, R.; Furll, C.; Gusovius, H.J. [Leibniz Inst. for Agricultural Engineering, Potsdam (Germany)

    2010-07-01

    The demand for high-quality fibres and shives from hemp and flax as an alternative raw material for the automotive and building industry is increasing. Fibres are used primarily for composite reinforcement instead of synthetic fibres. Shives are used for animal bedding, but processing trials in wood industry for the production of low weight particle boards from shives are also very promising. Fibre producers require experience in cultivation and harvesting as well as modern processing technologies in order to supply flax fibres or shives at competitive prices under the changing conditions of international raw material markets. A complete processing line has been developed, installed and tested at the Leibniz Institute for Agricultural Engineering (ATB) to study all the processing stages of fibre production. The new ATB line can produce high quality fibres and shives from retted and unretted hemp, flax and oilseed flax straw without technical changes of the machine line. The ATB pilot plant has been operated by a cooperation of farmers since 2008. Experience from industrial operation has been used to develop a modern fibre processing line with a throughput of up to 5 t per h hemp straw in only one short line.

  16. Anomalous magnetotransport properties of high-quality single crystals of Weyl semimetal WTe2: Sign change of Hall resistivity

    Science.gov (United States)

    Jha, Rajveer; Higashinaka, Ryuji; Matsuda, Tatsuma D.; Ribeiro, Raquel A.; Aoki, Yuji

    2018-05-01

    We report on a systematic study of Hall effect using high quality single crystals of type-II Weyl semimetal WTe2 with the applied magnetic field B//c. The residual resistivity ratio of 1330 and the large magnetoresistance of 1.5 × 106 % in 9 T at 2 K, being in the highest class in the literature, attest to their high quality. Based on a simple two-carrier model, the densities (ne and nh) and mobilities (μe and μh) for electron and hole carriers have been uniquely determined combining both Hall- and electrical-resistivity data. The difference between ne and nh is 1% at 2 K, indicating that the system is in an compensated condition. The negative Hall resistivity growing rapidly below 20 K is due to a rapidly increasing μh/μe approaching one. Below 3 K in a low field region, we found the Hall resistivity becomes positive, reflecting that μh/μe finally exceeds one in this region. These anomalous behaviors of the carrier densities and mobilities might be associated with the existence of a Lifshitz transition and/or the spin texture on the Fermi surface.

  17. Establishment of community mental health systems in a postdeinstitutional era: a study of organizational structures and service provision in Sweden.

    Science.gov (United States)

    Markström, Urban; Lindqvist, Rafael

    2015-01-01

    This article analyzes the state of community mental health services for people with psychiatric disabilities and the interplay between different organizational levels. The study is based on document analysis and interviews with stakeholders in 10 Swedish municipalities. The results show how systems are slow to change and are linked to local traditions. The services are often delivered in closed settings, and the organizations struggle to meet the needs of a new generation of users. There is a gap between local systems and national policies because the latter pays attention to the attributes of a recovery approach.

  18. Marine Corps Contract Supply Model for High Quality Male Enlistment Contracts at the Recruiting Sub Station Level

    National Research Council Canada - National Science Library

    Welsh, Brian K

    2008-01-01

    .... This research develops contract production models at the Recruiting Sub Station level to estimate the effects of local economic conditions, demographics, and recruiting resources on new high quality...

  19. High-Quality T2-Weighted 4-Dimensional Magnetic Resonance Imaging for Radiation Therapy Applications

    Energy Technology Data Exchange (ETDEWEB)

    Du, Dongsu [Department of Radiation Oncology, Washington University School of Medicine, Saint Louis, Missouri (United States); Caruthers, Shelton D. [Philips Healthcare, Cleveland, Ohio (United States); Glide-Hurst, Carri [Department of Radiation Oncology, Henry Ford Health System, Detroit, Michigan (United States); Low, Daniel A. [Department of Radiation Oncology, University of California-Los Angeles, Los Angeles, California (United States); Li, H. Harold; Mutic, Sasa [Department of Radiation Oncology, Washington University School of Medicine, Saint Louis, Missouri (United States); Hu, Yanle, E-mail: Hu.Yanle@mayo.edu [Department of Radiation Oncology, Washington University School of Medicine, Saint Louis, Missouri (United States); Department of Radiation Oncology, Mayo Clinic in Arizona, Phoenix, Arizona (United States)

    2015-06-01

    Purpose: The purpose of this study was to improve triggering efficiency of the prospective respiratory amplitude-triggered 4-dimensional magnetic resonance imaging (4DMRI) method and to develop a 4DMRI imaging protocol that could offer T2 weighting for better tumor visualization, good spatial coverage and spatial resolution, and respiratory motion sampling within a reasonable amount of time for radiation therapy applications. Methods and Materials: The respiratory state splitting (RSS) and multi-shot acquisition (MSA) methods were analytically compared and validated in a simulation study by using the respiratory signals from 10 healthy human subjects. The RSS method was more effective in improving triggering efficiency. It was implemented in prospective respiratory amplitude-triggered 4DMRI. 4DMRI image datasets were acquired from 5 healthy human subjects. Liver motion was estimated using the acquired 4DMRI image datasets. Results: The simulation study showed the RSS method was more effective for improving triggering efficiency than the MSA method. The average reductions in 4DMRI acquisition times were 36% and 10% for the RSS and MSA methods, respectively. The human subject study showed that T2-weighted 4DMRI with 10 respiratory states, 60 slices at a spatial resolution of 1.5 × 1.5 × 3.0 mm{sup 3} could be acquired in 9 to 18 minutes, depending on the individual's breath pattern. Based on the acquired 4DMRI image datasets, the ranges of peak-to-peak liver displacements among 5 human subjects were 9.0 to 12.9 mm, 2.5 to 3.9 mm, and 0.5 to 2.3 mm in superior-inferior, anterior-posterior, and left-right directions, respectively. Conclusions: We demonstrated that with the RSS method, it was feasible to acquire high-quality T2-weighted 4DMRI within a reasonable amount of time for radiation therapy applications.

  20. Study on methodologies for establishing a system for cross-border tariffication in the internal electricity market

    International Nuclear Information System (INIS)

    Glavitsch, H.

    2001-01-01

    This reports for the Swiss Federal Office of Energy (SFOE) presents the results of a study made by a working group on the costs and the billing of electrical power transfer across national borders in Europe. On the basis of present-day concepts and operating conditions, new methodologies were developed that were oriented towards the responsible parties, that were non-discriminating and that were based on physical energy flow. The results obtained with prototype calculation programs using test data are discussed and a cost-model that was intensively discussed in the working group is introduced. The software was developed far enough as to be able to perform simulations using a real-life set of data from the European grid. Together with the grid regulator in Belgium, a concept paper was developed that presents the targets and principal procedures involved in the new methodology developed in the project

  1. ESTABLISHING A PRIORITY HIERARCHICAL FOR REGIONAL AIRPORT INFRASTRUCTURE INVESTMENTS ACCORDING TO TOURISM DEVELOPMENT CRITERIA: A BRAZILIAN CASE STUDY

    Directory of Open Access Journals (Sweden)

    Elisangela A. M. Silva

    2017-12-01

    Full Text Available The Brazilian government stepped up investments in works related to improving access to cities, when it was announced as the venue for the 2014 Football World Cup. The difficulties observed to guide these investments were to select regional airports of greater relevance for the tourism sector. Given the unavailability of data that could serve this purpose, the present study sought to define, from secondary and qualitative information extracted from government documents, five indicators to allow a priority hierarchical. The methodology applied the hierarchical analysis method (AHP and standardization procedures, resulting in the selection of five airports in the North region, four airports in the Southeast, South and Northeast regions, and one in the Center-West region of Brazil. The main advantage of the methodology was the significant reduction of cost and time in the decision-making process. An important conclusion was the understanding of tourism as an option for regional economic diversification.

  2. Establishing a National Maternal Morbidity Outcome Indicator in England: A Population-Based Study Using Routine Hospital Data.

    Directory of Open Access Journals (Sweden)

    Manisha Nair

    Full Text Available As maternal deaths become rarer, monitoring near-miss or severe maternal morbidity becomes important as a tool to measure changes in care quality. Many calls have been made to use routinely available hospital administration data to monitor the quality of maternity care. We investigated 1 the feasibility of developing an English Maternal Morbidity Outcome Indicator (EMMOI by reproducing an Australian indicator using routinely available hospital data, 2 the impact of modifications to the indicator to address potential data quality issues, 3 the reliability of the indicator.We used data from 6,389,066 women giving birth in England from April 2003 to March 2013 available in the Hospital Episode Statistics (HES database of the Health and Social care Information centre (HSCIC. A composite indicator, EMMOI, was generated from the diagnoses and procedure codes. Rates of individual morbid events included in the EMMOI were compared with the rates in the UK reported by population-based studies.EMMOI included 26 morbid events (17 diagnosis and 9 procedures. Selection of the individual morbid events was guided by the Australian indicator and published literature for conditions associated with maternal morbidity and mortality in the UK, but was mainly driven by the quality of the routine hospital data. Comparing the rates of individual morbid events of the indicator with figures from population-based studies showed that the possibility of false positive and false negative cases cannot be ruled out.While routine English hospital data can be used to generate a composite indicator to monitor trends in maternal morbidity during childbirth, the quality and reliability of this monitoring indicator depends on the quality of the hospital data, which is currently inadequate.

  3. Evaluating methods to establish habitat suitability criteria: A case study in the upper Delaware River Basin, USA

    Science.gov (United States)

    Galbraith, Heather S.; Blakeslee, Carrie J.; Cole, Jeffrey C.; Talbert, Colin; Maloney, Kelly O.

    2016-01-01

    Defining habitat suitability criteria (HSC) of aquatic biota can be a key component to environmental flow science. HSC can be developed through numerous methods; however, few studies have evaluated the consistency of HSC developed by different methodologies. We directly compared HSC for depth and velocity developed by the Delphi method (expert opinion) and by two primary literature meta-analyses (literature-derived range and interquartile range) to assess whether these independent methods produce analogous criteria for multiple species (rainbow trout, brown trout, American shad, and shallow fast guild) and life stages. We further evaluated how these two independently developed HSC affect calculations of habitat availability under three alternative reservoir management scenarios in the upper Delaware River at a mesohabitat (main channel, stream margins, and flood plain), reach, and basin scale. In general, literature-derived HSC fell within the range of the Delphi HSC, with highest congruence for velocity habitat. Habitat area predicted using the Delphi HSC fell between the habitat area predicted using two literature-derived HSC, both at the basin and the site scale. Predicted habitat increased in shallow regions (stream margins and flood plain) using literature-derived HSC while Delphi-derived HSC predicted increased channel habitat. HSC generally favoured the same reservoir management scenario; however, no favoured reservoir management scenario was the most common outcome when applying the literature range HSC. The differences found in this study lend insight into how different methodologies can shape HSC and their consequences for predicted habitat and water management decisions. Published 2016. This article is a U.S. Government work and is in the public domain in the USA.

  4. Attempt at cloning high-quality goldfish breed 'Ranchu' by fin-cultured cell nuclear transplantation.

    Science.gov (United States)

    Tanaka, Daisuke; Takahashi, Akito; Takai, Akinori; Ohta, Hiromi; Ueno, Koichi

    2012-02-01

    The viability of ornamental fish culture relies on the maintenance of high-quality breeds. To improve the profitability of culture operations we attempted to produce cloned fish from the somatic nucleus of the high-quality Japanese goldfish (Carassius auratus auratus) breed 'Ranchu'. We transplanted the nucleus of a cultured fin-cell from an adult Ranchu into the non-enucleated egg of the original goldfish breed 'Wakin'. Of the 2323 eggs we treated, 802 underwent cleavage, 321 reached the blastula stage, and 51 reached the gastrula stage. Two of the gastrulas developed until the hatching stage. A considerable number of nuclear transplants retained only the donor nucleus. Some of these had only a 2n nucleus derived from the same donor fish. Our results provide insights into the process of somatic cell nuclear transplantation in teleosts, and the cloning of Ranchu.

  5. A design technique of low cost but high quality peak stretcher

    Energy Technology Data Exchange (ETDEWEB)

    Lo, H Y; Su, C S; Hsu, J Y; Wang, L

    1981-03-01

    This paper presents the design of low cost but high quality pulse peak stretcher incorporated with a LSI of 12 bit ADC and SKD-85 microcomputer. The conflict between the capacitor high charging speed and longer holding time for realizing a high quality stretcher is discussed and solved. For a lager number of channels available in a dual ramp Wilkinson-type ADC, two-stage stretchers connected in series are designed. The first stage is a fast-discharge to keep the output stretched pulse follow-up the input quickly and the second-stage (main stretcher) is a slow-discharge to keep the transient of the circuit minimum. Both of these two peak stretchers are described and the experiment results are photographically recorded.

  6. Recent developments in high-quality drying of vegetables, fruits, and aquatic products.

    Science.gov (United States)

    Zhang, Min; Chen, Huizhi; Mujumdar, Arun S; Tang, Juming; Miao, Song; Wang, Yuchuan

    2017-04-13

    Fresh foods like vegetables, fruits, and aquatic products have high water activity and they are highly heat-sensitive and easily degradable. Dehydration is one of the most common methods used to improve food shelf-life. However, drying methods used for food dehydration must not only be efficient and economic but also yield high-quality products based on flavor, nutrients, color, rehydration, uniformity, appearance, and texture. This paper reviews some new drying technologies developed for dehydration of vegetables, fruits, and aquatic products. These include: infrared drying, microwave drying, radio frequency drying, electrohydrodynamic drying, etc., as well as hybrid drying methods combining two or more different drying techniques. A comprehensive review of recent developments in high-quality drying of vegetables, fruits and aquatic products is presented and recommendations are made for future research.

  7. Formation of a high quality electron beam using photo cathode RF electron gun

    International Nuclear Information System (INIS)

    Washio, Masakazu

    2000-01-01

    Formation of a high quality electron beam using photo cathode RF electron gun is expected for formation of a next generation high brilliant X-ray beam and a source for electron and positron collider. And, on a field of material science, as is possible to carry out an experiment under ultra short pulse and extremely high precision in time, it collects large expectation. Recently, formation of high quality beam possible to develop for multi directions and to use by everyone in future has been able to realize. Here were explained on electron beam source, principle and component on RF electron gun, working features on RF gun, features and simulation of RF gun under operation, and some views in near future. (G.K.)

  8. High quality junctions by interpenetration of vapor liquid solid grown nanostructures for microchip integration

    Energy Technology Data Exchange (ETDEWEB)

    Jebril, Seid; Kuhlmann, Hanna; Adelung, Rainer [Funktionale Nanomaterialien, CAU Kiel (Germany); Mueller, Sven [Nanowires and Thin Films, II. Physikalisches Institut, Goettingen (Germany); Ronning, Carsten [Institute for Solid State Physics, Universitaet Jena (Germany); Kienle, Lorenz [Synthese und Realstruktur, CAU Kiel (Germany); Duppel, Viola [MPI fuer Festkoerperforschung, Stuttgart (Germany)

    2009-07-01

    The usability of nanostructures in electrical devices like gas sensors depends critically on the ability to form high quality contacts and junctions. For the fabrication of various nanostructures, vapor-liquid-solid (VLS) growth is a wide spread and very efficient technique. However, forming contacts with the VLS grown structures to utilize them in a device is still tedious, because either the substrate has to be epitaxial to the VLS material or a manual alignment is necessary. Here we demonstrate the contact formation by simply using the ability of individual crystals to interpenetrate each other during the straight forward VLS growth. This allows growing VLS structures directly on two neighboring gold circuit paths of a microchip; bridges over predefined gaps will be formed. Moreover, TEM investigations confirm the high quality of the crystalline junctions that allow demonstrations as UV and hydrogen-sensor. The VLS devices are compared with conventional produced.

  9. Establishing oral health promoting behaviours in children - parents' views on barriers, facilitators and professional support: a qualitative study.

    Science.gov (United States)

    Duijster, Denise; de Jong-Lenters, Maddelon; Verrips, Erik; van Loveren, Cor

    2015-12-10

    The prevention of childhood dental caries relies on adherence to key behaviours, including twice daily tooth brushing with fluoride toothpaste and reducing the consumption of sugary foods and drinks. The aim of this qualitative study was to explore parents' perceptions of barriers and facilitators that influence these oral health behaviours in children. A further objective was to explore parents' views on limitations and opportunities for professional support to promote children's oral health. Six focus group interviews were conducted, including a total of 39 parents of 7-year old children, who were recruited from paediatric dental centres in The Netherlands. Interviews were held with Dutch parents of low and high socioeconomic status and parents from Turkish and Moroccan origin. Focus group interviews were conducted on the basis of a pre-tested semi-structured interview guide and topic list. Content analysis was employed to analyse the data. Analysis of interview transcripts identified many influences on children's oral health behaviours, operating at child, family and community levels. Perceived influences on children's tooth brushing behaviour were primarily located within the direct family environment, including parental knowledge, perceived importance and parental confidence in tooth brushing, locus of control, role modelling, parental monitoring and supervision, parenting strategies and tooth brushing routines and habituation. The consumption of sugary foods and drinks was influenced by both the direct family environment and factors external to the family, including the school, the social environment, commercials and television, supermarkets and affordability of foods. Parents raised several suggestions for professional oral health support, which included the provision of clear and consistent oral health information using a positive approach, dietary regulations at school and a multidisciplinary approach among dental professionals, child health centres and

  10. Establishment of an Institute for Fusion Studies. Technical progress report, 1 November 1993--31 October 1994

    International Nuclear Information System (INIS)

    Hazeltine, R.D.

    1994-07-01

    The Institute for Fusion Studies is a national center for theoretical fusion plasma physics research. Its purposes are: (1) to conduct research on theoretical questions concerning the achievement of controlled fusion energy by means of magnetic confinement--including both fundamental problems of long-range significance, as well as shorter-term issues; (2) to serve as a national and international center for information exchange by hosting exchange visits, conferences, and workshops; (3) and to train students and postdoctoral research personnel for the fusion energy program and plasma physics research areas. The theoretical research results obtained by the Institute contribute to the progress of nuclear fusion research, whose goal is the development of fusion power as a basic energy source. Close collaborative relationships have been developed with other university and national laboratory fusion groups, both in the US and abroad. In addition to its primary focus on mainstream fusion physics, the Institute is also involved with research in fusion-sidestream fields, such as advanced computing techniques, nonlinear dynamics, space plasmas and astrophysics, statistical mechanics, fluid dynamics, and accelerator physics. Important research discoveries are briefly described

  11. Laparoscopic application of PGE2 to re-establish oviducal patency and fertility in infertile mares: a preliminary study.

    Science.gov (United States)

    Allen, W R; Wilsher, S; Morris, L; Crowhurst, J S; Hillyer, M H; Neal, H N

    2006-09-01

    Mares are occasionally encountered that consistently fail to conceive when inseminated, naturally or artificially, with fertile stallion semen in the absence of any identifiable pathology of either the structure or function of their reproductive tract. Temporary blockage of the oviducts by accumulations of naturally occurring oviducal masses may be preventing oviducal transport of the embryo to the uterus. Mares, with known reproductive histories, that had exhibited inexplicable failure of conception were treated by laparoscopically guided administration of PGE2-laced triacetin gel directly onto the surface of their oviducts. Fifteen mares age 10-21 years that had exhibited inexplicable failure of conception during 1-4 years were treated, of which 14 (93%) conceived within the same or subsequent breeding season. The high success rate of this treatment supports the tentative diagnosis of oviducal obstruction in these mares and indicates that blockage of the mare's oviducts may occur in the form of a moveable accumulation of debris rather than from permanent fibrous adhesions resulting from salpingitis. This laparoscopic application of PGE2 to the oviducts constitutes a sound and practical method of restoring fertility in mares suffering oviducal obstruction and further studies involving the procedure are warranted.

  12. Establishment of sustainable water supply system in small islands through rainwater harvesting (RWH): case study of Guja-do.

    Science.gov (United States)

    Han, Mooyoung; Ki, Jaehong

    2010-01-01

    Many islands in Korea have problems related to water source security and supply. In particular, the water supply condition is worse in small islands which are remote from the mainland. A couple of alternatives are developed and suggested to supply water to islands including water hauling, groundwater extraction, and desalination. However, these alternatives require much energy, cost, and concern in installation and operation. Rainwater harvesting is a sustainable option that supplies water with low energy and cost. However, lack of practical or comprehensive studies on rainwater harvesting systems in these regions hinders the promotion of the system. Therefore, this research examines defects of current RWH systems on an existing island, Guja-do, and provides technical suggestions in quantitative and qualitative aspects. A simple system design modification and expansion of system capacity using empty space such as a wharf structure can satisfy both the qualitative and the quantitative water demand of the island. Since rainwater harvesting is estimated to be a feasible water supply option under the Korean climate, which is an unfavorable condition for rainwater harvesting, implies a high potential applicability of rainwater harvesting technology to other regions over the world suffering from water shortage.

  13. Essential role of radiation therapy for the treatment of pancreatic cancer. Novel study concepts and established treatment recommendations

    International Nuclear Information System (INIS)

    Dobiasch, Sophie; Goerig, Nicole L.; Fietkau, Rainer; Combs, Stephanie E.

    2018-01-01

    Pancreatic cancer is one of the most aggressive human tumors and the incidence has increased over the last 6 years. In the majority of cases the disease is already in an advanced stage at the time of diagnosis where surgery, the only curative treatment, is no longer an option and explains the still abysmal overall survival. The role of radiation therapy as treatment option for patients with pancreatic cancer is controversially discussed although radiation oncology has emerged as a central pillar in the combined oncological treatment. The present manuscript gives an overview of advanced radiotherapeutic strategies in the context of chemotherapy and surgery according to the current American Society of Clinical Oncology (ASCO) guidelines in comparison with the German guidelines and to elucidate the role of radiation therapy for the treatment of pancreatic cancer. Advanced modern radiotherapeutic techniques in combination with individualized high-precision radiation concepts are new therapeutic approaches for pancreatic cancer in a multimodal setting with tolerable side effects. Several clinical studies together with experimental approaches are in process, to deliver further evidence and ultimately allow true personalized medicine. (orig.) [de

  14. Medicinal plants: traditions and study prospects (devoted to the 100th anniversary of establishing the Experimental Station of Medicinal Plants

    Directory of Open Access Journals (Sweden)

    О. С. Дем’янюк

    2016-12-01

    Full Text Available Historical review was done concerning the formation and development of scientific research of the Experimental Station of Medicinal Plants over the period 1916–2016. The main stages of experimenting in the direction of “medicinal plant cultivation’’ in Ukraine were covered. Role and importance of the Experimental Station of Medicinal Plants in the scientific and methodological support of such scientific directions as breeding, seed production, cultivation technologies, pharmacognosy in medicinal plant cultivation were shown. For the needs of the branch, over 100 species of introduced medicinal plants were studied at the Station and agricultu­ral techniques of their growing were developed, in addition, more than 50 varieties of medicinal plants were crea­ted, a number of machines and devices for growing, harves­ting and initial treatment of raw materials and seeds of the most important medicinal plants was designed. Other scientific achievements of the Station were mentioned and promising areas of medicinal plant research in Ukraine were outlined.

  15. Establishment of a new pull-out strength testing method to quantify early osseointegration-An experimental pilot study.

    Science.gov (United States)

    Nonhoff, J; Moest, T; Schmitt, Christian Martin; Weisel, T; Bauer, S; Schlegel, K A

    2015-12-01

    The animal study aims to evaluate a new experimental model for measuring sole the influence of the surface characteristics independent from implant macro-design on the level of osseointegration by registering the pull-out strength needed for removal of experimental devices with different surfaces from artificial defects. Seventy-two test bodies (36 with the FRIADENT(®) plus surface, 36 with the P15/HAp biofunctionalized surface) were inserted in six adult domestic pigs with artificial calvarial defects. The experimental devices were designed to fit in the defects leaving a gap between the test body and the local bone. After 21 days of healing, the animals were sacrificed and the test bodies were pulled out with a standardised reproducible pull-out device measuring the pull-out strength. The pull-out strength for both groups was compared. Twenty-one days after insertion a mean force of 412 ± 142 N for the P15/HAp group and 183 ± 105 N for the FRIADENT(®) plus group was measured for the removal of the specimens from the calvarial bone. The difference between the groups was statistically significant (p implant surfaces on the early stage of osseointegration. Copyright © 2015 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

  16. Production of high-quality polydisperse construction mixes for additive 3D technologies.

    Science.gov (United States)

    Gerasimov, M. D.; Brazhnik, Yu V.; Gorshkov, P. S.; Latyshev, S. S.

    2018-03-01

    The paper describes a new design of a mixer allowing production of high quality polydisperse powders, used in additive 3D technologies. A new principle of dry powder particle mixing is considered, implementing a possibility of a close-to-ideal distribution of such particles in common space. A mathematical model of the mixer is presented, allowing evaluating quality indicators of the produced mixture. Experimental results are shown and rational values of process parameters of the mixer are obtained.

  17. Project outline of high quality electron beam generation at Waseda University

    Energy Technology Data Exchange (ETDEWEB)

    Washio, M.; Hama, Y.; Kashiwagi, S.; Kuroda, R.; Kobuki, T. [Waseda Univ., Advanced Research Institute for Science and Engineering, Shinjuku, Tokyo (Japan); Hirose, T. [Tokyo Metropolitan Univ. (Japan). Dept. of Physics

    2000-03-01

    High quality electron beam generation project has been started at Waseda University under the grant of Ministry of Education, named High-Tech Research Center Project. In the project, we will install a laser photo-cathode RF Gun system with 1.6 accelerating structure cells of s-band and a stabilized RF power source. This RF Gun is expected to produce single electron bunch up to 1 or 2nC with around 10ps pulse duration. (author)

  18. Project outline of high quality electron beam generation at Waseda University

    International Nuclear Information System (INIS)

    Washio, M.; Hama, Y.; Kashiwagi, S.; Kuroda, R.; Kobuki, T.; Hirose, T.

    2000-01-01

    High quality electron beam generation project has been started at Waseda University under the grant of Ministry of Education, named High-Tech Research Center Project. In the project, we will install a laser photo-cathode RF Gun system with 1.6 accelerating structure cells of s-band and a stabilized RF power source. This RF Gun is expected to produce single electron bunch up to 1 or 2nC with around 10ps pulse duration. (author)

  19. Teaching Surgical Procedures with Movies: Tips for High-quality Video Clips

    OpenAIRE

    Jacquemart, Mathieu; Bouletreau, Pierre; Breton, Pierre; Mojallal, Ali; Sigaux, Nicolas

    2016-01-01

    Summary: Video must now be considered as a precious tool for learning surgery. However, the medium does present production challenges, and currently, quality movies are not always accessible. We developed a series of 7 surgical videos and made them available on a publicly accessible internet website. Our videos have been viewed by thousands of people worldwide. High-quality educational movies must respect strategic and technical points to be reliable.

  20. Teaching Surgical Procedures with Movies: Tips for High-quality Video Clips.

    Science.gov (United States)

    Jacquemart, Mathieu; Bouletreau, Pierre; Breton, Pierre; Mojallal, Ali; Sigaux, Nicolas

    2016-09-01

    Video must now be considered as a precious tool for learning surgery. However, the medium does present production challenges, and currently, quality movies are not always accessible. We developed a series of 7 surgical videos and made them available on a publicly accessible internet website. Our videos have been viewed by thousands of people worldwide. High-quality educational movies must respect strategic and technical points to be reliable.

  1. Quantitative Analysis of High-Quality Officer Selection by Commandants Career-Level Education Board

    Science.gov (United States)

    2017-03-01

    impact on the organization and allocate resources to improve the human capital of this select group. From 2011 onward, CCLEB revamped the application...ANALYSIS OF HIGH-QUALITY OFFICER SELECTION BY COMMANDANT’S CAREER - LEVEL EDUCATION BOARD by Clifton N. Rateike March 2017 Thesis Advisor...of Management and Budget, Paperwork Reduction Project (0704-0188) Washington, DC 20503. 1. AGENCY USE ONLY (Leave blank) 2. REPORT DATE March

  2. High-quality AlN films grown on chemical vapor-deposited graphene films

    Directory of Open Access Journals (Sweden)

    Chen Bin-Hao

    2016-01-01

    Full Text Available We report the growth of high-quality AlN films on graphene. The graphene films were synthesized by CVD and then transferred onto silicon substrates. Epitaxial aluminum nitride films were deposited by DC magnetron sputtering on both graphene as an intermediate layer and silicon as a substrate. The structural characteristics of the AlN films and graphene were investigated. Highly c-axis-oriented AlN crystal structures are investigated based on the XRDpatterns observations.

  3. Burnout in boiling heat transfer. Part III. High-quality forced-convection systems

    International Nuclear Information System (INIS)

    Bergles, A.E.

    1979-01-01

    This is the final part of a review of burnout during boiling heat transfer. The status of burnout in high-quality forced-convection systems is reviewed, and recent developments are summarized in detail. A general guide to the considerable literature is given. Parametric effects and correlations for water in circular and noncircular ducts are presented. Other topics discussed include transients, steam-generator applications, correlations for other fluids, fouling, and augmentation

  4. High-quality poly-dispersed mixtures applied in additive 3D technologies.

    Science.gov (United States)

    Gerasimov, M. D.; Brazhnik, Yu V.; Gorshkov, P. S.; Latyshev, S. S.

    2018-03-01

    The paper describes the new mixer design to obtain high-quality poly-dispersed powders applied in additive 3D technologies. It also considers a new mixing principle of dry powder particles ensuring the distribution of such particles in the total volume, which is close to ideal. The paper presents the mathematical model of mixer operation providing for the quality assessment of the ready mixtures. Besides, it demonstrates experimental results and obtained rational values of mixer process parameters.

  5. Generating high-quality single droplets for optical particle characterization with an easy setup

    Science.gov (United States)

    Xu, Jie; Ge, Baozhen; Meng, Rui

    2018-06-01

    The high-performance and micro-sized single droplet is significant for optical particle characterization. We develop a single-droplet generator (SDG) based on a piezoelectric inkjet technique with advantages of low cost and easy setup. By optimizing the pulse parameters, we achieve various size single droplets. Further investigations reveal that SDG generates single droplets of high quality, demonstrating good sphericity, monodispersity and a stable length of several millimeters.

  6. Research on the improvement of nuclear safety -A study on the establishment of severe accident experimental facility-

    Energy Technology Data Exchange (ETDEWEB)

    Seo, Kune Yull; Ryu, Keon Joong; Park, Chang Kyu; Sim, Seok Ku; Kim, Sang Baek; Nho, Ki Mann; Bang, Kwang Hyun; Park, Rae Jun; Lee, Seong Jae; Kang, Kyung Ho; Jo, Young Ro; Hong, Sung Wan; Jeong, Moon Ki; Park, Chun Kyung; Cheon, Se Young; Kim, In Sik; Moon, Sang Ki; Kim, Jong Hwan; Kim, Seong Ho; Sin, Ki Yeol; Cho, Jae Sun [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

    1995-07-01

    For the first phase (1992-1995) of the current research program under nuclear reactor safety enhancement project, the primary objective was placed on the development of an improved cavity design and on the improvement of theoretical models of the separate effects for major severe accident phenomena occurring in the reactor cavity. Also, during the fourth year of this project, small-scale experiments were performed to visualize the fundamental phenomena of boiling in narrow spaces that may exist between the debris crust and the reactor vessel lower head in preparation for the large-scale in-vessel cooling experiment planned for the second phase of the project (1996-2001). Separate effect tests have been performed during the first phase spanning the high pressure melt ejection (HPME) resulting in the direct containment heating (DCH), crust formation during cooling of the high temperature melt, fuel coolant interaction (FCI) in the process of injecting coolant onto the reactor cavity, and the molten core concrete interaction (MCCI). Some research programs were subcontracted with universities. Steam condensation on the containment inner wall was investigated by the POSTECH, while the experimental technique for the simultaneous measurement of particle size and velocity was developed by the KAIST. The second phase experimental projects center about the in-vessel accident management tests SONATA-IV (Simulation of Naturally Arrested Thermal Attack in Vessel) and ex-vessel accident management tests TOCATA-XV (Tests on Cavity Arrested Thermal Attack ex Vessel). In preparation for the second phase in-vessel experimental program, one of our research staff has participated in the PHEBUS-FP program in CEA Cadarache, France. Small-scale scoping tests were performed for the study of in-vessel cooling of debris in the lower head. (Abstract Truncated)

  7. Efficiency of PR communication in establishing links between archives and students: case study of the State Archives in Zadar

    Directory of Open Access Journals (Sweden)

    Goran Pavelin

    2013-03-01

    Full Text Available The aim of the paper is to highlight the changing role of archives and to use the case study to indicate the lacking communication with students due to the absence of PR activities, as well as to point to the difficulties of access to digital archival materials needed for student research. Using PR strategies the archives can sensitise the public for its material through different public programmes, exhibitions and fostering goodmedia relations. The archives try to develop good relations with target groups, in this case with students as potential users, taking into consideration their research needs and materials they are interested in. Research findings on student needs for archival data are extremely rare, even in recent American research. Therefore, we conducted this research using a questionnaire for students of four departments of the University of Zadar (geography, history, art history, tourism and communication, who were users of the State Archives in Zadar. The research results show whether the subjects use archival material, for what purposes, and what other resources they used prior to archival material. It also provides information on the level of familiarity with online archival material and use of web pages with archival resources. We can conclude that the students in Zadar are not well acquainted with the digital resources and use them rarely for their research purposes. The situation can be improved by having the State Archives in Zadar take a more proactive role in identifying target groups of students, their user profiles, difficulties they face, and by allowing a more flexible access to archival material. In addition to goo d relations with the Department of Information Sciences, the Archives should foster links with other departments and include them in planning and implementation of their programmes.

  8. Essential role of radiation therapy for the treatment of pancreatic cancer. Novel study concepts and established treatment recommendations

    Energy Technology Data Exchange (ETDEWEB)

    Dobiasch, Sophie [Technical University of Munich (TUM), Department of Radiation Oncology, Klinikum rechts der Isar, Munich (Germany); Goerig, Nicole L.; Fietkau, Rainer [Friedrich-Alexander-Universitaet Erlangen-Nuernberg, Department of Radiation Oncology, Universitaetsklinikum Erlangen, Erlangen (Germany); Combs, Stephanie E. [Technical University of Munich (TUM), Department of Radiation Oncology, Klinikum rechts der Isar, Munich (Germany); Helmholtz Zentrum Muenchen, Institute of Innovative Radiotherapy (iRT), Department of Radiation Sciences (DRS), Neuherberg (Germany)

    2018-03-15

    Pancreatic cancer is one of the most aggressive human tumors and the incidence has increased over the last 6 years. In the majority of cases the disease is already in an advanced stage at the time of diagnosis where surgery, the only curative treatment, is no longer an option and explains the still abysmal overall survival. The role of radiation therapy as treatment option for patients with pancreatic cancer is controversially discussed although radiation oncology has emerged as a central pillar in the combined oncological treatment. The present manuscript gives an overview of advanced radiotherapeutic strategies in the context of chemotherapy and surgery according to the current American Society of Clinical Oncology (ASCO) guidelines in comparison with the German guidelines and to elucidate the role of radiation therapy for the treatment of pancreatic cancer. Advanced modern radiotherapeutic techniques in combination with individualized high-precision radiation concepts are new therapeutic approaches for pancreatic cancer in a multimodal setting with tolerable side effects. Several clinical studies together with experimental approaches are in process, to deliver further evidence and ultimately allow true personalized medicine. (orig.) [German] Das Pankreaskarzinom gehoert zu den aggressivsten menschlichen Tumoren und verzeichnete in den letzten 6 Jahren eine steigende Inzidenz. Die Diagnose wird meist erst im fortgeschrittenen Stadium gestellt; dies schliesst haeufig eine primaer kurative Intervention mithilfe der chirurgischen Resektion aus und bedingt die hohe Mortalitaet. Obwohl die Strahlentherapie im multimodalen Therapieansatz des Pankreaskarzinoms eine zentrale Saeule darstellt, wird die Rolle der Strahlentherapie in der Literatur kontrovers diskutiert. Der vorliegende Beitrag bietet eine Uebersicht moderner Bestrahlungsstrategien im interdisziplinaeren Konzept gemaess der Leitlinien der American Society of Clinical Oncology (ASCO) im Vergleich zu den

  9. Reflections on two years after establishing an orthogeriatric unit: a focus group study of healthcare professionals' expectations and experiences.

    Science.gov (United States)

    Abrahamsen, C; Nørgaard, B; Draborg, E; Nielsen, D

    2017-08-25

    For decades hospitals have been "vertically" organized, with the risk that specialization leads to fragmented and one-sided views of patient care and treatment that may cause poor communication and coordination of care and treatment. Two years after the introduction of an orthogeriatric unit for elderly patients admitted with fragility fractures, we studied the involved healthcare professionals' perspectives and experiences with working in an interprofessional organization. We performed four focus groups interviews with 19 healthcare workers representing different professions. The interviews were analysed using systematic text condensation (STC). Three themes were identified: 1) A patient-centred approach, 2) An opportunity for professional growth and 3) The benefits of interprofessional collaboration. The interviewees emphasized in particular the systematic and frequent face-to-face communication enabled by the interprofessional team meetings as essential to their feeling of enhanced collegial solidarity. All groups expressed their respect for other groups' competences and their vital contributions to good orthogeriatric care. However, collaboration was challenged by the groups' divergent views of the patients and of the relevance of the information given in the weekly meetings. Heavy workloads were also mentioned. The opportunity for professional growth was also felt to be imperilled by some professionals. All participants indicated their view that the orthogeriatric organization had improved the quality of care and treatment. Furthermore, good communication, mutual respect for other professional competences and shared goals were found to have enhanced interprofessional collaboration and improved the sense of having a shared mission. However, differences in approaches and expectations continued to challenge the orthogeriatric model after 2 years. Neither did all professionals find orthogeriatric care professionally challenging.

  10. Establishing the resting state default mode network derived from functional magnetic resonance imaging tasks as an endophenotype: A twins study.

    Science.gov (United States)

    Korgaonkar, Mayuresh S; Ram, Kaushik; Williams, Leanne M; Gatt, Justine M; Grieve, Stuart M

    2014-08-01

    The resting state default mode network (DMN) has been shown to characterize a number of neurological and psychiatric disorders. Evidence suggests an underlying genetic basis for this network and hence could serve as potential endophenotype for these disorders. Heritability is a defining criterion for endophenotypes. The DMN is measured either using a resting-state functional magnetic resonance imaging (fMRI) scan or by extracting resting state activity from task-based fMRI. The current study is the first to evaluate heritability of this task-derived resting activity. 250 healthy adult twins (79 monozygotic and 46 dizygotic same sex twin pairs) completed five cognitive and emotion processing fMRI tasks. Resting state DMN functional connectivity was derived from these five fMRI tasks. We validated this approach by comparing connectivity estimates from task-derived resting activity for all five fMRI tasks, with those obtained using a dedicated task-free resting state scan in an independent cohort of 27 healthy individuals. Structural equation modeling using the classic twin design was used to estimate the genetic and environmental contributions to variance for the resting-state DMN functional connectivity. About 9-41% of the variance in functional connectivity between the DMN nodes was attributed to genetic contribution with the greatest heritability found for functional connectivity between the posterior cingulate and right inferior parietal nodes (P<0.001). Our data provide new evidence that functional connectivity measures from the intrinsic DMN derived from task-based fMRI datasets are under genetic control and have the potential to serve as endophenotypes for genetically predisposed psychiatric and neurological disorders. Copyright © 2014 Wiley Periodicals, Inc.

  11. Establishing a reference rock site for the site effect study in and around the Kathmandu valley, Nepal

    Science.gov (United States)

    Bhattarai, Mukunda; Adhikari, Lok Bijaya; Gautam, Umesh Prasad; Bollinger, Laurent; Hernandez, Bruno; Yokoi, Toshiaki; Hayashida, Takumi

    2016-05-01

    We propose a reference site for the site effect study in and around the Kathmandu valley, Nepal. The used data were the accelerograms recorded at two stations, DMG and KKA, and velocity seismograms co-recorded at the PKIN station during nine shallow local and regional earthquakes of local magnitude equal to or greater than 5.0. The DMG station is located on the thick sediments of the Kathmandu valley, whereas the others are rock sites. The KKA station is located on the granite and gneisses of the Shivapuri Lekh about 10 km northwest of the capital, and the PKIN station is in the tunnel of an old iron mine on the southern slope of the Phulchauki Hill about 15 km southeast. The spectral ratios of the ground motion records of the DMG station compared to those of the PKIN station, for all considered earthquakes, confirm that the DMG station has amplification ranging from 1 to 10 in the frequency range of 0.5-10 Hz, and spectral ratios of the KKA station referenced by the PKIN station show that the KKA station has significant amplification in the frequency range of 4-10 Hz and the peak value of the spectral ratio is at most over 25. Therefore, the site amplification in and around Kathmandu valley would be significantly underestimated in the frequency range from 4 to 10 Hz if the records of the KKA station were used as a proxy for input seismic motions to the sediment. Based on the above analysis, we propose that the PKIN station should be considered as a reliable reference site for the assessment of seismic hazards in and around the Kathmandu valley.

  12. Fast Batch Production of High-Quality Graphene Films in a Sealed Thermal Molecular Movement System.

    Science.gov (United States)

    Xu, Jianbao; Hu, Junxiong; Li, Qi; Wang, Rubing; Li, Weiwei; Guo, Yufen; Zhu, Yongbo; Liu, Fengkui; Ullah, Zaka; Dong, Guocai; Zeng, Zhongming; Liu, Liwei

    2017-07-01

    Chemical vapor deposition (CVD) growth of high-quality graphene has emerged as the most promising technique in terms of its integrated manufacturing. However, there lacks a controllable growth method for producing high-quality and a large-quantity graphene films, simultaneously, at a fast growth rate, regardless of roll-to-roll (R2R) or batch-to-batch (B2B) methods. Here, a stationary-atmospheric-pressure CVD (SAPCVD) system based on thermal molecular movement, which enables fast B2B growth of continuous and uniform graphene films on tens of stacked Cu(111) foils, with a growth rate of 1.5 µm s -1 , is demonstrated. The monolayer graphene of batch production is found to nucleate from arrays of well-aligned domains, and the films possess few defects and exhibit high carrier mobility up to 6944 cm 2 V -1 s -1 at room temperature. The results indicate that the SAPCVD system combined with single-domain Cu(111) substrates makes it possible to realize fast batch-growth of high-quality graphene films, which opens up enormous opportunities to use this unique 2D material for industrial device applications. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  13. HPHT growth and x-ray characterization of high-quality type IIa diamond.

    Science.gov (United States)

    Burns, R C; Chumakov, A I; Connell, S H; Dube, D; Godfried, H P; Hansen, J O; Härtwig, J; Hoszowska, J; Masiello, F; Mkhonza, L; Rebak, M; Rommevaux, A; Setshedi, R; Van Vaerenbergh, P

    2009-09-09

    The trend in synchrotron radiation (x-rays) is towards higher brilliance. This may lead to a very high power density, of the order of hundreds of watts per square millimetre at the x-ray optical elements. These elements are, typically, windows, polarizers, filters and monochromators. The preferred material for Bragg diffracting optical elements at present is silicon, which can be grown to a very high crystal perfection and workable size as well as rather easily processed to the required surface quality. This allows x-ray optical elements to be built with a sufficient degree of lattice perfection and crystal processing that they may preserve transversal coherence in the x-ray beam. This is important for the new techniques which include phase-sensitive imaging experiments like holo-tomography, x-ray photon correlation spectroscopy, coherent diffraction imaging and nanofocusing. Diamond has a lower absorption coefficient than silicon, a better thermal conductivity and lower thermal expansion coefficient which would make it the preferred material if the crystal perfection (bulk and surface) could be improved. Synthetic HPHT-grown (high pressure, high temperature) type Ib material can readily be produced in the necessary sizes of 4-8 mm square and with a nitrogen content of typically a few hundred parts per million. This material has applications in the less demanding roles such as phase plates: however, in a coherence-preserving beamline, where all elements must be of the same high quality, its quality is far from sufficient. Advances in HPHT synthesis methods have allowed the growth of type IIa diamond crystals of the same size as type Ib, but with substantially lower nitrogen content. Characterization of this high purity type IIa material has been carried out with the result that the crystalline (bulk) perfection of some of the HPHT-grown materials is approaching the quality required for the more demanding applications such as imaging applications and imaging

  14. A Study on the establishment of environmental friendly taxation system II - concentrated on calculation of environmental friendly subsidy and taxation reform

    Energy Technology Data Exchange (ETDEWEB)

    Noh, Sang Hwan; Lim, Hyun Jung [Korea Environment Institute, Seoul (Korea)

    1998-12-01

    Establishing an environmental friendly taxation system, designing to have a sustainable development and environmental conservation simultaneously, is an important problem to be solved. Following the study on calculation of water and energy subsidy in previous year, the amount of environmental unfriendly subsidy in transportation and agriculture was calculated. Based on the introduction plan of new environmental tax, such as carbon tax and product share, a scheme of environmental friendly taxation reform was proposed. 48 refs., 5 figs., 88 tabs.

  15. High Quality Zinc Oxide Thin films and Nanostructures Prepared by Pulsed Laser Deposition for Photodetectors

    KAUST Repository

    Flemban, Tahani H.

    2017-12-11

    Zinc oxide (ZnO) semiconductors have been utilized by many researchers, due to its unique properties beneficial for functional devices. In particular, gadolinium (Gd)–doped ZnO exhibits high ferromagnetic and electrical properties, which is attributed to defect/impurity bands mediated by Gd dopants. In this dissertation, I study the effects of Gd concentration, oxygen pressure using pulsed laser deposition (PLD), and thermal annealing on the optical and structural properties of undoped and Gd-doped ZnO films and nanostructures. Moreover, as the growth of practical ZnO nanostructures-based devices without catalyst, while presently challenging, is highly important for many applications. Thus, for the first time, a novel method is developed for growing well aligned ZnO nanorods (NRs) by optimizing PLD conditions using Gd-doped ZnO target without any catalyst in a single step. This study shows that, both the lattice orientation of the substrate and the Gd characteristics are significant in enhancing the NR growth. Our findings reveal that precise control of the NR density can be achieved by changing the oxygen partial pressure. Furthermore, due to the Gd incorporation, these NRs possess favorable electrical properties with a significant mobility of 177 cm2 (V.s)-1 compared to that reported in literature. Nonetheless significant challenges need to be overcome to achieve reproducible and stable p-type ZnO for commercial applications. Hence, several attempts based on n-type ZnO grown on foreign p-type substrates were made to achieve high-performance devices and overcome the issues arising when p-type doped ZnO is employed. Moreover, Growth of ZnO nanostructures on a foreign p-type substrates does not require a lattice-matched p-type substrate. Thus, for the first time, PLD conditions are improved to grow high quality ZnO nanotubes (NTs) with high optical, structural and electrical properties on a p-type Si (100) substrate without catalyst for high-performance devices. A

  16. High quality RNA isolation from Aedes aegypti midguts using laser microdissection microscopy

    Directory of Open Access Journals (Sweden)

    Gobert Geoffrey N

    2011-05-01

    Full Text Available Abstract Background Laser microdissection microscopy (LMM has potential as a research tool because it allows precise excision of target tissues or cells from a complex biological specimen, and facilitates tissue-specific sample preparation. However, this method has not been used in mosquito vectors to date. To this end, we have developed an LMM method to isolate midgut RNA using Aedes aegypti. Results Total RNA was isolated from Ae. aegypti midguts that were either fresh-frozen or fixed with histological fixatives. Generally, fresh-frozen tissue sections are a common source of quality LMM-derived RNA; however, our aim was to develop an LMM protocol that could inactivate pathogenic viruses by fixation, while simultaneously preserving RNA from arbovirus-infected mosquitoes. Three groups (10 - 15 mosquitoes per group of female Ae. aegypti at 24 or 48-hours post-blood meal were intrathoracically injected with one of seven common fixatives (Bouin's, Carnoy's, Formoy's, Cal-Rite, 4% formalin, 10% neutral buffered formalin, or zinc formalin to evaluate their effect on RNA quality. Total RNA was isolated from the fixed abdomens using a Trizol® method. The results indicated that RNA from Carnoy's and Bouin's fixative samples was comparable to that of fresh frozen midguts (control in duplicate experiments. When Carnoy's and Bouin's were used to fix the midguts for the LMM procedure, however, Carnoy's-fixed RNA clearly showed much less degradation than Bouin's-fixed RNA. In addition, a sample of 5 randomly chosen transcripts were amplified more efficiently using the Carnoy's treated LMM RNA than Bouin's-fixed RNA in quantitative real-time PCR (qRT-PCR assays, suggesting there were more intact target mRNAs in the Carnoy's fixed RNA. The yields of total RNA ranged from 0.3 to 19.0 ng per ~3.0 × 106 μm2 in the LMM procedure. Conclusions Carnoy's fixative was found to be highly compatible with LMM, producing high quality RNA from Ae. aegypti midguts while

  17. Comparative Amino Acids Studies on Phac Synthases and Proteases as Well as Establishing a New Trend in Experimental Design

    Directory of Open Access Journals (Sweden)

    Amro Abd al fattah Amara

    2012-04-01

    Full Text Available ABSTRACT: A question addressed in this study is: why similar enzymes are classified into different subclasses? As an example, PhaC synthases are classified according to four different classes (I, II, III and IV. To answer this question we proposed that besides the catalytic residues, the overall amino acids (AAs present are responsible for the differences observed. The AAs’ composition affects the structure/function/substrate specificity (SFS of these enzymes. The differences between the classes in various PhaC synthases and proteases were analysed to support our argument. Homology and phylogenic tree of some selected PhaC synthases of different strains (representing the four classes were demonstrated. The properties of a specific class of enzyme could not be changed into those of another by changing the catalytic residues. Moreover, these differences could not be detected from the proteins’ 3D structures, despite clear differences at the AAs level. Another question was also addressed: could we benefit from the various existing protein databases in the field of biotechnology? To answer this, we introduced a model for an Experimental Design based on the information in the protein database (for strains available in our lab regarding their ability to degrade castor oil. Two enzymes in the phenol degradation pathway, phenol 2-monooxygenase and catechol 1,2-dioxygenase, and a lipase enzyme were analysed. These enzymes were screened and analysed according to the BLAST-protein database and BRENDA. The comprehensive enzyme information system compared six strains against each other, including: Pseudomonas aeruginosa, Bacillus subtilis, Bacillus pumilus, Bacillus thuringiensis, Bacillus licheniformis, and Geobacillus stearothermophilus. Only P. aeruginosa proved to have the three required enzymes and was suitable for the production of lipases from castor oil (crude castor oil is usually contaminated with phenol as indicated by the databases. In

  18. Data Analytic Process of a Nationwide Population-Based Study Using National Health Information Database Established by National Health Insurance Service

    Directory of Open Access Journals (Sweden)

    Yong-ho Lee

    2016-02-01

    Full Text Available In 2014, the National Health Insurance Service (NHIS signed a memorandum of understanding with the Korean Diabetes Association to provide limited open access to its databases for investigating the past and current status of diabetes and its management. NHIS databases include the entire Korean population; therefore, it can be used as a population-based nationwide study for various diseases, including diabetes and its complications. This report presents how we established the analytic system of nation-wide population-based studies using the NHIS database as follows: the selection of database study population and its distribution and operational definition of diabetes and patients of currently ongoing collaboration projects.

  19. ESSD: Real World Issues and Challenges of High-Quality Data Publication

    Science.gov (United States)

    Pfeiffenberger, Hans; Carlson, David

    2013-04-01

    The Copernicus data publication journal Earth System Science Data (ESSD) represents an important and unique (and by no means final!) step forward in the larger world of data publication. Working with authors, reviewers, editors and data centres, ESSD has successfully produced many high-quality data publications across a wide variety of scientific disciplines, for individual data sets, multiple data sets as the product of scientific consortia and in special issues coordinated with other science journals. The ESSD success also exposes issues and challenges for present and future data publication, particularly around the topic and implementation of persistent identifiers. • As ESSD encourages redundant data sets across multiple data centres for access and archive purposes, how will DOIs be employed to accurately point to those distributed or replicated data? How can authenticity and integrity be verified? • How can or should object identifiers be employed in pointing from raw to quality-controlled and finally derived data processing levels; how can we designate or distinguish among these, particularly as those terms vary substantially among, for example, geophysical and ecological communities? Likewise, how to distinguish an auto-generated data product (e.g a species identification from GBIF) from a high-effort expertly reviewed data product (e.g. an ESSD publication)? • For a growing number of ESSD data publications with expected annual or periodic revisions and updates, how should data journals' and the repositories' use of persistent identifiers best record the subsequent versions, extensions or corrections? • As published data sets become a valued part of high profile science, with attendant deadlines, announcements and publicity, do the various DOI policies and minting practices among cooperating publishers, data centres and journals represent a help or a hindrance? These questions evolve directly from increasing interest in and activity by ESSD and, as

  20. Task-based statistical image reconstruction for high-quality cone-beam CT

    Science.gov (United States)

    Dang, Hao; Webster Stayman, J.; Xu, Jennifer; Zbijewski, Wojciech; Sisniega, Alejandro; Mow, Michael; Wang, Xiaohui; Foos, David H.; Aygun, Nafi; Koliatsos, Vassilis E.; Siewerdsen, Jeffrey H.

    2017-11-01

    promising regularization method in MBIR by explicitly incorporating task-based imaging performance as the objective. The results demonstrate improved ICH conspicuity and support the development of high-quality CBCT systems.