Analytic theory for the selection of 2-D needle crystal at arbitrary Peclet number
Tanveer, Saleh
1989-01-01
An accurate analytic theory is presented for the velocity selection of a two-dimensional needle crystal for arbitrary Peclet number for small values of the surface tension parameter. The velocity selection is caused by the effect of transcendentally small terms which are determined by analytic continuation to the complex plane and analysis of nonlinear equations. The work supports the general conclusion of previous small Peclet number analytical results of other investigators, though there are some discrepancies in details. It also addresses questions raised on the validity of selection theory owing to assumptions made on shape corrections at large distances from the tip.
Analytic theory for the selection of a two-dimensional needle crystal at arbitrary Peclet number
Tanveer, S.
1989-01-01
An accurate analytic theory is presented for the velocity selection of a two-dimensional needle crystal for arbitrary Peclet number for small values of the surface tension parameter. The velocity selection is caused by the effect of transcendentally small terms which are determined by analytic continuation to the complex plane and analysis of nonlinear equations. The work supports the general conclusion of previous small Peclet number analytical results of other investigators, though there are some discrepancies in details. It also addresses questions raised on the validity of selection theory owing to assumptions made on shape corrections at large distances from the tip.
Empirical correlations for axial dispersion coefficient and Peclet number in fixed-bed columns.
Rastegar, Seyed Omid; Gu, Tingyue
2017-03-24
In this work, a new correlation for the axial dispersion coefficient was obtained using experimental data in the literature for axial dispersion in fixed-bed columns packed with particles. The Chung and Wen correlation, the De Ligny correlation are two popular empirical correlations. However, the former lacks the molecular diffusion term and the latter does not consider bed voidage. The new axial dispersion coefficient correlation in this work was based on additional experimental data in the literature by considering both molecular diffusion and bed voidage. It is more comprehensive and accurate. The Peclet number correlation from the new axial dispersion coefficient correlation on the average leads to 12% lower Peclet number values compared to the values from the Chung and Wen correlation, and in many cases much smaller than those from the De Ligny correlation. Copyright © 2017 Elsevier B.V. All rights reserved.
Low Mach and Peclet number limit for a model of stellar tachocline and upper radiative zones
Donatella Donatelli
2016-09-01
Full Text Available We study a hydrodynamical model describing the motion of internal stellar layers based on compressible Navier-Stokes-Fourier-Poisson system. We suppose that the medium is electrically charged, we include energy exchanges through radiative transfer and we assume that the system is rotating. We analyze the singular limit of this system when the Mach number, the Alfven number, the Peclet number and the Froude number approache zero in a certain way and prove convergence to a 3D incompressible MHD system with a stationary linear transport equation for transport of radiation intensity. Finally, we show that the energy equation reduces to a steady equation for the temperature corrector.
Wang, Wentao; Lee, Yi Kuen
2012-01-01
Both theoretical analysis and nonlinear 2D numerical simulations are used to study the concentration difference and Peclet number effect on the measurement error of electroosmotic mobility in microchannels. We propose a compact analytical model
Wang, Wentao
2012-03-01
Both theoretical analysis and nonlinear 2D numerical simulations are used to study the concentration difference and Peclet number effect on the measurement error of electroosmotic mobility in microchannels. We propose a compact analytical model for this error as a function of normalized concentration difference and Peclet number in micro electroosmotic flow. The analytical predictions of the errors are consistent with the numerical simulations. © 2012 IEEE.
Role of the Structural and Thermal Peclet Numbers in the Brass Continuous Casting
Kwapisiński P.
2017-06-01
Full Text Available The Structural Peclet Number has been estimated experimentally by analyzing the morphology of the continuously cast brass ingots. It allowed to adapt a proper development of the Ivantsov’s series in order to formulate the Growth Law for the columnar structure formation in the brass ingots solidified in stationary condition. Simultaneously, the Thermal Peclet Number together with the Biot, Stefan, and Fourier Numbers is used in the model describing the heat transfer connected with the so-called contact layer (air gap between an ingot and crystallizer. It lead to define the shape and position of the s/l interface in the brass ingot subjected to the vertical continuous displacement within the crystallizer (in gravity. Particularly, a comparison of the shape of the simulated s/l interface at the axis of the continuously cast brass ingot with the real shape revealed at the ingot axis is delivered. Structural zones in the continuously cast brass ingot are revealed: FC - fine columnar grains, C - columnar grains, E - equiaxed grains, SC - single crystal situated axially.
Severino, Gerardo; Cuomo, Salvatore; Sommella, Angelo; D'urso, Guido
2017-10-01
We consider transport of a conservative solute through an aquifer as determined: (i) by the advective velocity, which depends upon the hydraulic conductivity K and (ii) by the local spreading due to the pore-scale dispersion (PSD). The flow is steady, and it takes place in a porous formation where, owing to its erratic spatial variations, the hydraulic log conductivity Y≡lnK is modeled as a stationary Gaussian random field. The relative effect of the above mechanisms (i)-(ii) is quantified by the Peclet number>(Pe>) which, in most of the previous studies, was considered infinite (i.e., no PSD) due to the overtake of advective heterogeneities upon the PSD. Here we aim at generalizing such studies by accounting for the impact of finite Pe on conservative transport. Previous studies on the topic required extensive numerical computations. In the present note, we remove the computational burden by adopting the rational approximate expression of Dagan and Cvetkovic (1993) for the covariance of the velocity field. This allows one to obtain closed form expressions for the quantities characterizing the longitudinal plume's dispersion. Transport can be straightforwardly investigated by dealing with a modified Peclet number>(Pe>¯>) incorporating both the PSD and the aquifer's anisotropy. The satisfactory match to Cape Cod field data suggests that the present theoretical results lend themselves as a useful tool to assess the impact of the PSD upon conservative transport through heterogeneous porous formations.
Zhang, Yong; Green, Christopher T.; Tick, Geoffrey R.
2015-01-01
This study evaluates the role of the Peclet number as affected by molecular diffusion in transient anomalous transport, which is one of the major knowledge gaps in anomalous transport, by combining Monte Carlo simulations and stochastic model analysis. Two alluvial settings containing either short- or long-connected hydrofacies are generated and used as media for flow and transport modeling. Numerical experiments show that 1) the Peclet number affects both the duration of the power-law segment of tracer breakthrough curves (BTCs) and the transition rate from anomalous to Fickian transport by determining the solute residence time for a given low-permeability layer, 2) mechanical dispersion has a limited contribution to the anomalous characteristics of late-time transport as compared to molecular diffusion due to an almost negligible velocity in floodplain deposits, and 3) the initial source dimensions only enhance the power-law tail of the BTCs at short travel distances. A tempered stable stochastic (TSS) model is then applied to analyze the modeled transport. Applications show that the time-nonlocal parameters in the TSS model relate to the Peclet number, Pe. In particular, the truncation parameter in the TSS model increases nonlinearly with a decrease in Pe due to the decrease of the mean residence time, and the capacity coefficient increases with an increase in molecular diffusion which is probably due to the increase in the number of immobile particles. The above numerical experiments and stochastic analysis therefore reveal that the Peclet number as affected by molecular diffusion controls transient anomalous transport in alluvial aquifer–aquitard complexes.
A. Abdullah
2018-04-01
Full Text Available Convection-diffusion problems, due to its fundamental nature, are found in various science and engineering applications. In this research, the importance of the relationship between grid structure and flow parameters in such problems is emphasized. In particular, we propose a systematic technique in the selection of the grid expansion factor based on its logarithmic relationship with low Peclet number. Such linear mathematical connection between the two non-dimensional parameters serves as a guideline for more structured decision-making and improves the heuristic process in the determination of the computational domain grid for the numerical solution of convection-diffusion equations especially in the prediction of the concentration of the scalar. Results confirm the effectiveness of the new approach.
Suresh, P V; Jayanti, Sreenivas
2016-10-01
Adoption of hydrogen economy by means of using hydrogen fuel cells is one possible solution for energy crisis and climate change issues. Polymer electrolyte membrane (PEM) fuel cell, which is an important type of fuel cells, suffers from the problem of water management. Cross-flow is induced in some flow field designs to enhance the water removal. The presence of cross-flow in the serpentine and interdigitated flow fields makes them more effective in proper distribution of the reactants on the reaction layer and evacuation of water from the reaction layer than diffusion-based conventional parallel flow fields. However, too much of cross-flow leads to flow maldistribution in the channels, higher pressure drop, and membrane dehydration. In this study, an attempt has been made to quantify the amount of cross-flow required for effective distribution of reactants and removal of water in the gas diffusion layer. Unit cells containing two adjacent channels with gas diffusion layer (GDL) and catalyst layer at the bottom have been considered for the parallel, interdigitated, and serpentine flow patterns. Computational fluid dynamics-based simulations are carried out to study the reactant transport in under-the-rib area with cross-flow in the GDL. A new criterion based on the Peclet number is presented as a quantitative measure of cross-flow in the GDL. The study shows that a cross-flow Peclet number of the order of 2 is required for effective removal of water from the GDL. Estimates show that this much of cross-flow is not usually produced in the U-bends of Serpentine flow fields, making these areas prone to flooding.
Selander, W.N.; Lane, F.E.; Rowat, J.H.
1995-05-01
A groundwater mass transfer calculation is an essential part of the performance assessment for radioactive waste disposal facilities. AECL's IRUS (Intrusion Resistant Underground Structure) facility, which is designed for the near-surface disposal of low-level radioactive waste (LLRW), is to be situated in the sandy overburden at AECL's Chalk River Laboratories. Flow in the sandy aquifers at the proposed IRUS site is relatively homogeneous and advection-dominated (large Peclet numbers). Mass transfer along the mean direction of flow from the IRUS site may be described using the one-dimensional advection-dispersion equation, for which a Green's function representation of downstream radionuclide flux is convenient. This report shows that in advection-dominated aquifers, dispersive attenuation of initial contaminant releases depends principally on two time scales: the source duration and the pulse breakthrough time. Numerical investigation shows further that the maximum downstream flux or concentration depends on these time scales in a simple characteristic way that is minimally sensitive to the shape of the initial source pulse. (author). 11 refs., 2 tabs., 3 figs
Johansen, Per; Roemer, Daniel Beck; Andersen, Torben Ole
2014-01-01
A conventional simplification of the thermal problem in fluid film lubrication analysis is performed by assuming that the main direction of heat flow is conduction through the film thickness, and thereby neglecting convection. However, in a significant amount of applications, convection is not ne......A conventional simplification of the thermal problem in fluid film lubrication analysis is performed by assuming that the main direction of heat flow is conduction through the film thickness, and thereby neglecting convection. However, in a significant amount of applications, convection...... is not negligible, whereby the majority of design engineers exclusively use numerical solvers. This paper presents a perturbation series expansion of the temperature field for small values of the Brinkman number. The derived perturbation solution and the more conventional analytical solution, where convection...
Review of numerical methods for radionuclide transport in 3d porous media at high Peclet numbers
Spalding, D.B.; Pun, W.M.
1986-10-01
This programme of work considers the relative accuracy exhibited by several alternative means of formulating the advection - diffusion equation, in three dimensions, with particular reference to the limitation of computing resources. It is concluded that the accuracy depends mainly on the formula used for the average concentration of pollutant in the fluid in a computational cell during a given time step. This average value of concentration is reasonably regarded as the weighted average of the upstream, downstream and neighbour values at the start and finish of the time step and the cell surface dimensions. Of the formulations surveyed, those of Leith and Leonard performed best, albeit with a tendency to develop non-physical overshoots. The fully explicit upwind formulation performed worst of all but was free from the non-physical problem. In general the moving grid formulation performed most satisfactorily when applied to many practical situations. (author)
High Reynolds Number Turbulence
Smits, Alexander J
2007-01-01
The objectives of the grant were to provide a systematic study to fill the gap between existing research on low Reynolds number turbulent flows to the kinds of turbulent flows encountered on full-scale vehicles...
Convection in an ideal gas at high Rayleigh numbers.
Tilgner, A
2011-08-01
Numerical simulations of convection in a layer filled with ideal gas are presented. The control parameters are chosen such that there is a significant variation of density of the gas in going from the bottom to the top of the layer. The relations between the Rayleigh, Peclet, and Nusselt numbers depend on the density stratification. It is proposed to use a data reduction which accounts for the variable density by introducing into the scaling laws an effective density. The relevant density is the geometric mean of the maximum and minimum densities in the layer. A good fit to the data is then obtained with power laws with the same exponent as for fluids in the Boussinesq limit. Two relations connect the top and bottom boundary layers: The kinetic energy densities computed from free fall velocities are equal at the top and bottom, and the products of free fall velocities and maximum horizontal velocities are equal for both boundaries.
Finite volume simulation of 2-D steady square lid driven cavity flow at high reynolds numbers
K. Yapici
2013-12-01
Full Text Available In this work, computer simulation results of steady incompressible flow in a 2-D square lid-driven cavity up to Reynolds number (Re 65000 are presented and compared with those of earlier studies. The governing flow equations are solved by using the finite volume approach. Quadratic upstream interpolation for convective kinematics (QUICK is used for the approximation of the convective terms in the flow equations. In the implementation of QUICK, the deferred correction technique is adopted. A non-uniform staggered grid arrangement of 768x768 is employed to discretize the flow geometry. Algebraic forms of the coupled flow equations are then solved through the iterative SIMPLE (Semi-Implicit Method for Pressure-Linked Equation algorithm. The outlined computational methodology allows one to meet the main objective of this work, which is to address the computational convergence and wiggled flow problems encountered at high Reynolds and Peclet (Pe numbers. Furthermore, after Re > 25000 additional vortexes appear at the bottom left and right corners that have not been observed in earlier studies.
Low Mach and Peclet number limit for a model of stellar tachocline and upper radiative zones
Donatelli, D.; Ducomet, B.; Kobera, M.; Nečasová, Šárka
2016-01-01
Roč. 2016, Č. 245 (2016), s. 1-31 ISSN 1072-6691 R&D Projects: GA ČR GA16-03230S Institutional support: RVO:67985840 Keywords : Navier-Stokes-Fourier-Poisson system * radiation transfer * compressible magnetohydrodynamics Subject RIV: BA - General Math ematics Impact factor: 0.954, year: 2016 http://ejde. math .txstate.edu/Volumes/2016/245/abstr.html
Baryon number violation in high energy collisions
Farrar, G.R.; Meng, R.
1990-08-01
We study the phenomenology of baryon number violation induced by electroweak instantons. We find that if the naive-instanton amplitudes were valid for arbitrarily high energies, the event rate at the SSC would be a few per hour, with a typical event consisting of 3 'primary' antileptons and 7 'primary' antiquark jets, accompanied by ≅ 85 electroweak gauge bosons, having a sharp threshold in the total sub-energy at about 17 TeV. We describe how to establish their electroweak-instanton-induced origin. The naive instanton approximation is known to overestimate the rate for these processes, so this work focusses attention on the need for more accurate calculations, and for a calculational method which is appropriate when the energy of the initial particles is above the sphaleron energy. (orig.)
Partial Cavity Flows at High Reynolds Numbers
Makiharju, Simo; Elbing, Brian; Wiggins, Andrew; Dowling, David; Perlin, Marc; Ceccio, Steven
2009-11-01
Partial cavity flows created for friction drag reduction were examined on a large-scale. Partial cavities were investigated at Reynolds numbers up to 120 million, and stable cavities with frictional drag reduction of more than 95% were attained at optimal conditions. The model used was a 3 m wide and 12 m long flat plate with a plenum on the bottom. To create the partial cavity, air was injected at the base of an 18 cm backwards-facing step 2.1 m from the leading edge. The geometry at the cavity closure was varied for different flow speeds to optimize the closure of the cavity. Cavity gas flux, thickness, frictional loads, and cavity pressures were measured over a range of flow speeds and air injection fluxes. High-speed video was used extensively to investigate the unsteady three dimensional cavity closure, the overall cavity shape and oscillations.
Random Number Generation for High Performance Computing
2015-01-01
number streams, a quality metric for the parallel random number streams. * * * * * Atty. Dkt . No.: 5660-14400 Customer No. 35690 Eric B. Meyertons...responsibility to ensure timely payment of maintenance fees when due. Pagel of3 PTOL-85 (Rev. 02/11) Atty. Dkt . No.: 5660-14400 Page 1 Meyertons...with each subtask executed by a separate thread or process (henceforth, process). Each process has Atty. Dkt . No.: 5660-14400 Page 2 Meyertons
Penetrative convection at high Rayleigh numbers
Toppaladoddi, Srikanth; Wettlaufer, John S.
2018-04-01
We study penetrative convection of a fluid confined between two horizontal plates, the temperatures of which are such that a temperature of maximum density lies between them. The range of Rayleigh numbers studied is Ra=[0.01 ,4 ]106,108 and the Prandtl numbers are Pr=1 and 11.6. An evolution equation for the growth of the convecting region is obtained through an integral energy balance. We identify a new nondimensional parameter, Λ , which is the ratio of temperature difference between the stable and unstable regions of the flow; larger values of Λ denote increased stability of the upper stable layer. We study the effects of Λ on the flow field using well-resolved lattice Boltzmann simulations and show that the characteristics of the flow depend sensitively upon it. For the range Λ = , we find that for a fixed Ra the Nusselt number, Nu, increases with decreasing Λ . We also investigate the effects of Λ on the vertical variation of convective heat flux and the Brunt-Väisälä frequency. Our results clearly indicate that in the limit Λ →0 the problem reduces to that of the classical Rayleigh-Bénard convection.
The High/Scope Report. Number Four.
Silverman, Charles, Ed.
This report provides articles on several topics related to the education of young children. In the introduction High/Scope President David P. Weikart suggests that public investment in preschool education is a wise and economically sound social policy. New studies of the long term effects of preschool are demonstrating the staying power of early…
Dimensionless numbers in additive manufacturing
Mukherjee, T.; Manvatkar, V.; De, A.; DebRoy, T.
2017-02-01
The effects of many process variables and alloy properties on the structure and properties of additively manufactured parts are examined using four dimensionless numbers. The structure and properties of components made from 316 Stainless steel, Ti-6Al-4V, and Inconel 718 powders for various dimensionless heat inputs, Peclet numbers, Marangoni numbers, and Fourier numbers are studied. Temperature fields, cooling rates, solidification parameters, lack of fusion defects, and thermal strains are examined using a well-tested three-dimensional transient heat transfer and fluid flow model. The results show that lack of fusion defects in the fabricated parts can be minimized by strengthening interlayer bonding using high values of dimensionless heat input. The formation of harmful intermetallics such as laves phases in Inconel 718 can be suppressed using low heat input that results in a small molten pool, a steep temperature gradient, and a fast cooling rate. Improved interlayer bonding can be achieved at high Marangoni numbers, which results in vigorous circulation of liquid metal, larger pool dimensions, and greater depth of penetration. A high Fourier number ensures rapid cooling, low thermal distortion, and a high ratio of temperature gradient to the solidification growth rate with a greater tendency of plane front solidification.
Small numbers are sensed directly, high numbers constructed from size and density.
Zimmermann, Eckart
2018-04-01
Two theories compete to explain how we estimate the numerosity of visual object sets. The first suggests that the apparent numerosity is derived from an analysis of more low-level features like size and density of the set. The second theory suggests that numbers are sensed directly. Consistent with the latter claim is the existence of neurons in parietal cortex which are specialized for processing the numerosity of elements in the visual scene. However, recent evidence suggests that only low numbers can be sensed directly whereas the perception of high numbers is supported by the analysis of low-level features. Processing of low and high numbers, being located at different levels of the neural hierarchy should involve different receptive field sizes. Here, I tested this idea with visual adaptation. I measured the spatial spread of number adaptation for low and high numerosities. A focused adaptation spread of high numerosities suggested the involvement of early neural levels where receptive fields are comparably small and the broad spread for low numerosities was consistent with processing of number neurons which have larger receptive fields. These results provide evidence for the claim that different mechanism exist generating the perception of visual numerosity. Whereas low numbers are sensed directly as a primary visual attribute, the estimation of high numbers however likely depends on the area size over which the objects are spread. Copyright © 2017 Elsevier B.V. All rights reserved.
Modelling of high-enthalpy, high-Mach number flows
Degrez, G; Lani, A; Panesi, M; Chazot, O; Deconinck, H
2009-01-01
A review is made of the computational models of high-enthalpy flows developed over the past few years at the von Karman Institute and Universite Libre de Bruxelles, for the modelling of high-enthalpy hypersonic (re-)entry flows. Both flows in local thermo-chemical equilibrium (LTE) and flows in thermo-chemical non-equilibrium (TCNEQ) are considered. First, the physico-chemical models are described, i.e. the set of conservation laws, the thermodynamics, transport phenomena and chemical kinetics models. Particular attention is given to the correct modelling of elemental (LTE flows) and species (chemical non-equilibrium-CNEQ-flows) transport. The numerical algorithm, based on a state-of-the-art finite volume discretization, is then briefly described. Finally, selected examples are included to illustrate the capabilities of the developed solver. (review article)
Towards a high-speed quantum random number generator
Stucki, Damien; Burri, Samuel; Charbon, Edoardo; Chunnilall, Christopher; Meneghetti, Alessio; Regazzoni, Francesco
2013-10-01
Randomness is of fundamental importance in various fields, such as cryptography, numerical simulations, or the gaming industry. Quantum physics, which is fundamentally probabilistic, is the best option for a physical random number generator. In this article, we will present the work carried out in various projects in the context of the development of a commercial and certified high speed random number generator.
Promoting Number Theory in High Schools or Birthday Problem and Number Theory
Srinivasan, V. K.
2010-01-01
The author introduces the birthday problem in this article. This can amuse willing members of any birthday party. This problem can also be used as the motivational first day lecture in number theory for the gifted students in high schools or in community colleges or in undergraduate classes in colleges.
High Reynolds number flows using liquid and gaseous helium
Donnelly, R.J.
1991-01-01
Consideration is given to liquid and gaseous helium as test fluids, high Reynolds number test requirements in low speed aerodynamics, the measurement of subsonic flow around an appended body of revolution at cryogenic conditions in the NTF, water tunnels, flow visualization, the six component magnetic suspension system for wind tunnel testing, and recent aerodynamic measurements with magnetic suspension systems. Attention is also given to application of a flow visualization technique to a superflow experiment, experimental investigations of He II flows at high Reynolds numbers, a study of homogeneous turbulence in superfluid helium, and thermal convection in liquid helium
Impact of High Mathematics Education on the Number Sense
Castronovo, Julie; Göbel, Silke M.
2012-01-01
In adult number processing two mechanisms are commonly used: approximate estimation of quantity and exact calculation. While the former relies on the approximate number sense (ANS) which we share with animals and preverbal infants, the latter has been proposed to rely on an exact number system (ENS) which develops later in life following the acquisition of symbolic number knowledge. The current study investigated the influence of high level math education on the ANS and the ENS. Our results showed that the precision of non-symbolic quantity representation was not significantly altered by high level math education. However, performance in a symbolic number comparison task as well as the ability to map accurately between symbolic and non-symbolic quantities was significantly better the higher mathematics achievement. Our findings suggest that high level math education in adults shows little influence on their ANS, but it seems to be associated with a better anchored ENS and better mapping abilities between ENS and ANS. PMID:22558077
Reducing high Reynolds number hydroacoustic noise using superhydrophobic coating
Elboth, Thomas; Reif, Bjørn Anders Pettersson; Andreassen, Øyvind; Martell, Michael B
2011-01-01
The objective of this study is to assess and quantify the effect of a superhydrophobic surface coating on turbulence-generated flow noise. The study utilizes results obtained from high Reynolds-number full-scale flow noise measurements taken on a commercial seismic streamer and results from low Reynolds-number direct numerical simulations. It is shown that it is possible to significantly reduce both the frictional drag and the levels of the turbulence generated flow noise even at very high Reynolds-numbers. For instance, frequencies below 10 Hz a reduction in the flow noise level of nearly 50% was measured. These results can be attributed to a reduced level of shear stress and change in the kinematic structure of the turbulence, both of which occur in the immediate vicinity of the superhydrophobic surface.
Wire-number effects on high-power annular z-pinches and some characteristics at high wire number
SANFORD,THOMAS W. L.
2000-05-23
Characteristics of annular wire-array z-pinches as a function of wire number and at high wire number are reviewed. The data, taken primarily using aluminum wires on Saturn are comprehensive. The experiments have provided important insights into the features of wire-array dynamics critical for high x-ray power generation, and have initiated a renaissance in z-pinches when high numbers of wires are used. In this regime, for example, radiation environments characteristic of those encountered during the early pulses required for indirect-drive ICF ignition on the NIF have been produced in hohlraums driven by x-rays from a z-pinch, and are commented on here.
Wire-number effects on high-power annular z-pinches and some characteristics at high wire number
SANFORD, THOMAS W. L.
2000-01-01
Characteristics of annular wire-array z-pinches as a function of wire number and at high wire number are reviewed. The data, taken primarily using aluminum wires on Saturn are comprehensive. The experiments have provided important insights into the features of wire-array dynamics critical for high x-ray power generation, and have initiated a renaissance in z-pinches when high numbers of wires are used. In this regime, for example, radiation environments characteristic of those encountered during the early pulses required for indirect-drive ICF ignition on the NIF have been produced in hohlraums driven by x-rays from a z-pinch, and are commented on here
Very high performance pseudo-random number generation on DAP
Smith, K. A.; Reddaway, S. F.; Scott, D. M.
1985-07-01
Since the National DAP Service began at QMC in 1980, extensive use has been made of pseudo-random numbers in Monte Carlo simulation. Matrices of uniform numbers have been produced by various generators: (a) multiplicative ( x+ 1 = 13 13xn mod 2 59); (b) very long period shift register ( x4423 + x271 + 1); (c) multiple shorter period ( x127 + x7 + 1) shift registers generating several matrices per iteration. The above uniform generators can also feed a normal distribution generator that uses the Box-Muller transformation. This paper describes briefly the generators, their implementation and speed. Generator (b) has been greatly speeded-up by re-implementation, and now produces more than 100 × 10 6 high quality 16-bit numbers/s. Generator (c) is under development and will achieve even higher performance, mainly due to producing data in greater bulk. High quality numbers are expected, and performance will range from 400 to 800 × 10 6 numbers/s, depending on how the generator is used.
Very high Mach number shocks - Theory. [in space plasmas
Quest, Kevin B.
1986-01-01
The theory and simulation of collisionless perpendicular supercritical shock structure is reviewed, with major emphasis on recent research results. The primary tool of investigation is the hybrid simulation method, in which the Newtonian orbits of a large number of ion macroparticles are followed numerically, and in which the electrons are treated as a charge neutralizing fluid. The principal results include the following: (1) electron resistivity is not required to explain the observed quasi-stationarity of the earth's bow shock, (2) the structure of the perpendicular shock at very high Mach numbers depends sensitively on the upstream value of beta (the ratio of the thermal to magnetic pressure) and electron resistivity, (3) two-dimensional turbulence will become increasingly important as the Mach number is increased, and (4) nonadiabatic bulk electron heating will result when a thermal electron cannot complete a gyrorbit while transiting the shock.
Plume structure in high-Rayleigh-number convection
Puthenveettil, Baburaj A.; Arakeri, Jaywant H.
2005-10-01
Near-wall structures in turbulent natural convection at Rayleigh numbers of 10^{10} to 10^{11} at A Schmidt number of 602 are visualized by a new method of driving the convection across a fine membrane using concentration differences of sodium chloride. The visualizations show the near-wall flow to consist of sheet plumes. A wide variety of large-scale flow cells, scaling with the cross-section dimension, are observed. Multiple large-scale flow cells are seen at aspect ratio (AR)= 0.65, while only a single circulation cell is detected at AR= 0.435. The cells (or the mean wind) are driven by plumes coming together to form columns of rising lighter fluid. The wind in turn aligns the sheet plumes along the direction of shear. the mean wind direction is seen to change with time. The near-wall dynamics show plumes initiated at points, which elongate to form sheets and then merge. Increase in rayleigh number results in a larger number of closely and regularly spaced plumes. The plume spacings show a common log normal probability distribution function, independent of the rayleigh number and the aspect ratio. We propose that the near-wall structure is made of laminar natural-convection boundary layers, which become unstable to give rise to sheet plumes, and show that the predictions of a model constructed on this hypothesis match the experiments. Based on these findings, we conclude that in the presence of a mean wind, the local near-wall boundary layers associated with each sheet plume in high-rayleigh-number turbulent natural convection are likely to be laminar mixed convection type.
Computation of high Reynolds number internal/external flows
Cline, M. C.; Wilmoth, R. G.
1981-01-01
A general, user oriented computer program, called VNAP2, was developed to calculate high Reynolds number, internal/ external flows. The VNAP2 program solves the two dimensional, time dependent Navier-Stokes equations. The turbulence is modeled with either a mixing-length, a one transport equation, or a two transport equation model. Interior grid points are computed using the explicit MacCormack Scheme with special procedures to speed up the calculation in the fine grid. All boundary conditions are calculated using a reference plane characteristic scheme with the viscous terms treated as source terms. Several internal, external, and internal/external flow calculations are presented.
Computation of high Reynolds number internal/external flows
Cline, M.C.; Wilmoth, R.G.
1981-01-01
A general, user oriented computer program, called VNAP2, has been developed to calculate high Reynolds number, internal/external flows. VNAP2 solves the two-dimensional, time-dependent Navier-Stokes equations. The turbulence is modeled with either a mixing-length, a one transport equation, or a two transport equation model. Interior grid points are computed using the explicit MacCormack scheme with special procedures to speed up the calculation in the fine grid. All boundary conditions are calculated using a reference plane characteristic scheme with the viscous terms treated as source terms. Several internal, external, and internal/external flow calculations are presented
Angular dependence of high Mach number plasma interactions
Thomas, V.A.; Brecht, S.H.
1987-01-01
In this paper a 2-1/2-dimensional hybrid code is used to examine the collisionless large spatial scale (kc/ω pi ∼ 1) low-frequency (ω ∼ ω ci ) interaction initiated by a plasma shell of finite width traveling at high Alfven Mach number relative to a uniform background plasma. Particular attention is given to the angle of the relative velocity relative to the ambient magnetic field for the range of angles O < θ < π/2. An attempt is made to parameterize some of the important physics including the Alfven ion cyclotron instability, the field-aligned electromagnetic ion counter streaming instability, mixing of the plasma shell with the background ions, and structuring of the interaction region. These results are applicable to various astrophysical interactions such as bow shocks and interplanetary shocks
Performance Limiting Flow Processes in High-State Loading High-Mach Number Compressors
Tan, Choon S
2008-01-01
In high-stage loading high-Mach number (HLM) compressors, counter-rotating pairs of discrete vortices are shed at the trailing edge of the upstream blade row at a frequency corresponding to the downstream rotor blade passing frequency...
The Granular Blasius Problem: High inertial number granular flows
Tsang, Jonathan; Dalziel, Stuart; Vriend, Nathalie
2017-11-01
The classical Blasius problem considers the formation of a boundary layer through the change at x = 0 from a free-slip to a no-slip boundary beneath an otherwise steady uniform flow. Discrete particle model (DPM) simulations of granular gravity currents show that a similar phenomenon exists for a steady flow over a uniformly sloped surface that is smooth upstream (allowing slip) but rough downstream (imposing a no-slip condition). The boundary layer is a region of high shear rate and therefore high inertial number I; its dynamics are governed by the asymptotic behaviour of the granular rheology as I -> ∞ . The μ(I) rheology asserts that dμ / dI = O(1 /I2) as I -> ∞ , but current experimental evidence is insufficient to confirm this. We show that `generalised μ(I) rheologies', with different behaviours as I -> ∞ , all permit the formation of a boundary layer. We give approximate solutions for the velocity profile under each rheology. The change in boundary condition considered here mimics more complex topography in which shear stress increases in the streamwise direction (e.g. a curved slope). Such a system would be of interest in avalanche modelling. EPSRC studentship (Tsang) and Royal Society Dorothy Hodgkin Fellowship (Vriend).
High-Mach number, laser-driven magnetized collisionless shocks
Schaeffer, Derek B.; Fox, W.; Haberberger, D.; Fiksel, G.; Bhattacharjee, A.
2017-01-01
Collisionless shocks are ubiquitous in space and astrophysical systems, and the class of supercritical shocks is of particular importance due to their role in accelerating particles to high energies. While these shocks have been traditionally studied by spacecraft and remote sensing observations, laboratory experiments can provide reproducible and multi-dimensional datasets that provide complementary understanding of the underlying microphysics. We present experiments undertaken on the OMEGA and OMEGA EP laser facilities that show the formation and evolution of high-Mach number collisionless shocks created through the interaction of a laser-driven magnetic piston and magnetized ambient plasma. Through time-resolved, 2-D imaging we observe large density and magnetic compressions that propagate at super-Alfvenic speeds and that occur over ion kinetic length scales. Electron density and temperature of the initial ambient plasma are characterized using optical Thomson scattering. Measurements of the piston laser-plasma are modeled with 2-D radiation-hydrodynamic simulations, which are used to initialize 2-D particle-in-cell simulations of the interaction between the piston and ambient plasmas. The numerical results show the formation of collisionless shocks, including the separate dynamics of the carbon and hydrogen ions that constitute the ambient plasma and their effect on the shock structure. Furthermore, the simulations also show the shock separating from the piston, which we observe in the data at late experimental times.
Transitional boundary layer in low-Prandtl-number convection at high Rayleigh number
Schumacher, Joerg; Bandaru, Vinodh; Pandey, Ambrish; Scheel, Janet
2016-11-01
The boundary layer structure of the velocity and temperature fields in turbulent Rayleigh-Bénard flows in closed cylindrical cells of unit aspect ratio is revisited from a transitional and turbulent viscous boundary layer perspective. When the Rayleigh number is large enough the boundary layer dynamics at the bottom and top plates can be separated into an impact region of downwelling plumes, an ejection region of upwelling plumes and an interior region (away from side walls) that is dominated by a shear flow of varying orientation. This interior plate region is compared here to classical wall-bounded shear flows. The working fluid is liquid mercury or liquid gallium at a Prandtl number of Pr = 0 . 021 for a range of Rayleigh numbers of 3 ×105 Deutsche Forschungsgemeinschaft.
Amati, G.; Koal, K.; Massaioli, F.; Sreenivasan, K.R.; Verzicco, R.
2006-12-01
The results from direct numerical simulations of turbulent Boussinesq convection are briefly presented. The flow is computed for a cylindrical cell of aspect ratio 1/2 in order to compare with the results from recent experiments. The results span eight decades of Ra from 2x10 6 to 2x10 14 and form the baseline data for a strictly Boussinesq fluid of constant Prandtl number (Pr=0.7). A conclusion is that the Nusselt number varies nearly as the 1/3 power of Ra for about four decades towards the upper end of the Ra range covered. (author)
Perturbed Partial Cavity Drag Reduction at High Reynolds Numbers
Makiharju, Simo; Elbing, Brian; Wiggins, Andrew; Dowling, David; Perlin, Marc; Ceccio, Steven
2010-11-01
Ventilated partial cavities were investigated at Reynolds numbers to 80 million. These cavities could be suitable for friction drag reduction on ocean going vessels and thereby lead to environmental and economical benefits. The test model was a 3.05 m wide by 12.9 m long flat plate, with a 0.18 m backward-facing step and a cavity-terminating beach, which had an adjustable slope, tilt and height. The step and beach trapped a ventilated partial cavity over the longitudinal mid-section of the model. Large-scale flow perturbations, mimicking the effect of ambient ocean waves were investigated. For the conditions tested a cavity could be maintained under perturbed flow conditions when the gas flux supplied was greater than the minimum required to maintain a cavity under steady conditions, with larger perturbations requiring more excess gas flux to maintain the cavity. High-speed video was used to observe the unsteady three dimensional cavity closure, the overall cavity shape, and the cavity oscillations. Cavities with friction drag reduction exceeding 95% were attained at optimal conditions. A simplified energy cost-benefit analysis of partial cavity drag reduction was also performed. The results suggest that PCDR could potentially lead to energy savings.
Prandtl-number Effects in High-Rayleigh-number Spherical Convection
Orvedahl, Ryan J.; Calkins, Michael A.; Featherstone, Nicholas A.; Hindman, Bradley W.
2018-03-01
Convection is the predominant mechanism by which energy and angular momentum are transported in the outer portion of the Sun. The resulting overturning motions are also the primary energy source for the solar magnetic field. An accurate solar dynamo model therefore requires a complete description of the convective motions, but these motions remain poorly understood. Studying stellar convection numerically remains challenging; it occurs within a parameter regime that is extreme by computational standards. The fluid properties of the convection zone are characterized in part by the Prandtl number \\Pr = ν/κ, where ν is the kinematic viscosity and κ is the thermal diffusion; in stars, \\Pr is extremely low, \\Pr ≈ 10‑7. The influence of \\Pr on the convective motions at the heart of the dynamo is not well understood since most numerical studies are limited to using \\Pr ≈ 1. We systematically vary \\Pr and the degree of thermal forcing, characterized through a Rayleigh number, to explore its influence on the convective dynamics. For sufficiently large thermal driving, the simulations reach a so-called convective free-fall state where diffusion no longer plays an important role in the interior dynamics. Simulations with a lower \\Pr generate faster convective flows and broader ranges of scales for equivalent levels of thermal forcing. Characteristics of the spectral distribution of the velocity remain largely insensitive to changes in \\Pr . Importantly, we find that \\Pr plays a key role in determining when the free-fall regime is reached by controlling the thickness of the thermal boundary layer.
Vortex Shedding from Tapered Cylinders at high Reynolds Numbers
Johansson, Jens; Andersen, Michael Styrk; Christensen, Silas Sverre
2015-01-01
percent for strakes of circular cross section. The present paper argues that this height can be reduced for structures where the critical wind velocity for vortex shedding is in the Supercritical Reynolds number regime. The present investigations are aimed for suppressing VIV on offshore wind turbine......^5 (Supercritical). Results indicate that circular strakes with a diameter corresponding to 3 percent of the structures mean diameter can be used to efficiently reduce VIV in the Supercritical Reynolds number regime....
Mass transfer controlled reactions in packed beds at low Reynolds numbers
Fedkiw, P.S.
1978-12-01
The a priori prediction and correlation of mass-transfer rates in transport limited, packed-bed reactors at low Reynolds numbers is examined. The solutions to the governing equations for a flow-through porous electrode reactor indicate that these devices must operate at a low space velocity to suppress a large ohmic potential drop. Packed-bed data for the mass-transfer rate at such low Reynolds numbers were examined and found to be sparse, especially in liquid systems. Prior models to simulate the solid-void structure in a bed are reviewed. Here the bed was envisioned as an array of sinusoidal periodically constricted tubes (PCT). Use of this model has not appeared in the literature. The velocity field in such a tube should be a good approximation to the converging-diverging character of the velocity field in an actual bed. The creeping flow velocity profiles were calculated. These results were used in the convective-diffusion equation to find mass transfer rates at high Peclet number for both deep and shallow beds, for low Peclet numbers in a deep bed. All calculations assumed that the reactant concentration at the tube surface is zero. Mass-transfer data were experimentally taken in a transport controlled, flow-through porous electrode to test the theoretical calculations and to provide data resently unavailable for deeper beds. It was found that the sinusoidal PCT model could not fit the data of this work or that available in the literature. However, all data could be adequately described by a model which incorporates a channelingeffect. The bed was successfully modeled as an array of dual sized straight tubes.
Crossover from High to Low Reynolds Number Turbulence
Lohse, Detlef
1994-01-01
The Taylor-Reynolds and Reynolds number (Re lambda and Re) dependence of the dimensionless energy dissipation rate c epsilon = epsilon L / u31,rms is derived for statistically stationary isotropic turbulence, employing the results of a variable range mean field theory. Here epsilon is the energy
Multiplier less high-speed squaring circuit for binary numbers
Sethi, Kabiraj; Panda, Rutuparna
2015-03-01
The squaring operation is important in many applications in signal processing, cryptography etc. In general, squaring circuits reported in the literature use fast multipliers. A novel idea of a squaring circuit without using multipliers is proposed in this paper. Ancient Indian method used for squaring decimal numbers is extended here for binary numbers. The key to our success is that no multiplier is used. Instead, one squaring circuit is used. The hardware architecture of the proposed squaring circuit is presented. The design is coded in VHDL and synthesised and simulated in Xilinx ISE Design Suite 10.1 (Xilinx Inc., San Jose, CA, USA). It is implemented in Xilinx Vertex 4vls15sf363-12 device (Xilinx Inc.). The results in terms of time delay and area is compared with both modified Booth's algorithm and squaring circuit using Vedic multipliers. Our proposed squaring circuit seems to have better performance in terms of both speed and area.
High Reynolds number oscillations of a circular cylinder
Hirata, Miguel H.; Pereira, Luiz Antonio A.; Recicar, Jan N.; Moura, Washington H. de
2008-01-01
This paper concerns the numerical simulation of the flow around an oscillating circular cylinder, which moves with constant velocity in a quiescent Newtonian fluid with constant properties. For each time step of the simulation a number of discrete Lamb vortices is placed close to the body surface; the intensity of each of these is determined such as to satisfy the no-slip boundary condition. The aerodynamic loads acting on the surface of cylinder are computed using the integral formulation de...
BROADENING OF BALMER LINES FOR HIGH QUANTUM NUMBER
Armstrong, B. H.
1963-10-15
It is shown that the impact theory breakdown at sufficiently large distances from the line center in effect lowers the principle quantum number at which electron broadening might otherwise be assumed to dominate. Since the impact theory breaks down and effectively the impact widths decrease progressively for the line components more distant from the center, the contributions of the components to the folding integral decrease rapidly except at their own positions. (R.E.U.)
Turbulent boundary layer in high Rayleigh number convection in air.
du Puits, Ronald; Li, Ling; Resagk, Christian; Thess, André; Willert, Christian
2014-03-28
Flow visualizations and particle image velocimetry measurements in the boundary layer of a Rayleigh-Bénard experiment are presented for the Rayleigh number Ra=1.4×1010. Our visualizations indicate that the appearance of the flow structures is similar to ordinary (isothermal) turbulent boundary layers. Our particle image velocimetry measurements show that vorticity with both positive and negative sign is generated and that the smallest flow structures are 1 order of magnitude smaller than the boundary layer thickness. Additional local measurements using laser Doppler velocimetry yield turbulence intensities up to I=0.4 as in turbulent atmospheric boundary layers. From our observations, we conclude that the convective boundary layer becomes turbulent locally and temporarily although its Reynolds number Re≈200 is considerably smaller than the value 420 underlying existing phenomenological theories. We think that, in turbulent Rayleigh-Bénard convection, the transition of the boundary layer towards turbulence depends on subtle details of the flow field and is therefore not universal.
Design of a High-Reynolds Number Recirculating Water Tunnel
Daniel, Libin; Elbing, Brian
2014-11-01
An experimental fluid mechanics laboratory focused on turbulent boundary layers, drag reduction techniques, multiphase flows and fluid-structure interactions has recently been established at Oklahoma State University. This laboratory has three primary components; (1) a recirculating water tunnel, (2) a multiphase pipe flow loop, and (3) a multi-scale flow visualization system. The design of the water tunnel is the focus of this talk. The criteria used for the water tunnel design was that it had to produce a momentum-thickness based Reynolds number in excess of 104, negligible flow acceleration due to boundary layer growth, maximize optical access for use of the flow visualization system, and minimize inlet flow non-uniformity. This Reynolds number was targeted to bridge the gap between typical university/commercial water tunnels (103) and the world's largest water tunnel facilities (105) . These objectives were achieved with a 152 mm (6-inch) square test section that is 1 m long and has a maximum flow speed of 10 m/s. The flow non-uniformity was mitigated with the use of a tandem honeycomb configuration, a settling chamber and an 8.5:1 contraction. The design process that produced this final design will be presented along with its current status.
Effects of viscoelasticity in the high Reynolds number cylinder wake
Richter, David
2012-01-16
At Re = 3900, Newtonian flow past a circular cylinder exhibits a wake and detached shear layers which have transitioned to turbulence. It is the goal of the present study to investigate the effects which viscoelasticity has on this state and to identify the mechanisms responsible for wake stabilization. It is found through numerical simulations (employing the FENE-P rheological model) that viscoelasticity greatly reduces the amount of turbulence in the wake, reverting it back to a state which qualitatively appears similar to the Newtonian mode B instability which occurs at lower Re. By focusing on the separated shear layers, it is found that viscoelasticity suppresses the formation of the Kelvin-Helmholtz instability which dominates for Newtonian flows, consistent with previous studies of viscoelastic free shear layers. Through this shear layer stabilization, the viscoelastic far wake is then subject to the same instability mechanisms which dominate for Newtonian flows, but at far lower Reynolds numbers. © Copyright Cambridge University Press 2012.
Numerical simulation of high Reynolds number bubble motion
McLaughlin, J.B. [Clarkson Univ., Potsdam, NY (United States)
1995-12-31
This paper presents the results of numerical simulations of bubble motion. All the results are for single bubbles in unbounded fluids. The liquid phase is quiescent except for the motion created by the bubble, which is axisymmetric. The main focus of the paper is on bubbles that are of order 1 mm in diameter in water. Of particular interest is the effect of surfactant molecules on bubble motion. Results for the {open_quotes}insoluble surfactant{close_quotes} model will be presented. These results extend research by other investigators to finite Reynolds numbers. The results indicate that, by assuming complete coverage of the bubble surface, one obtains good agreement with experimental observations of bubble motion in tap water. The effect of surfactant concentration on the separation angle is discussed.
Effects of viscoelasticity in the high Reynolds number cylinder wake
Richter, David; Iaccarino, Gianluca; Shaqfeh, Eric S. G.
2012-01-01
At Re = 3900, Newtonian flow past a circular cylinder exhibits a wake and detached shear layers which have transitioned to turbulence. It is the goal of the present study to investigate the effects which viscoelasticity has on this state and to identify the mechanisms responsible for wake stabilization. It is found through numerical simulations (employing the FENE-P rheological model) that viscoelasticity greatly reduces the amount of turbulence in the wake, reverting it back to a state which qualitatively appears similar to the Newtonian mode B instability which occurs at lower Re. By focusing on the separated shear layers, it is found that viscoelasticity suppresses the formation of the Kelvin-Helmholtz instability which dominates for Newtonian flows, consistent with previous studies of viscoelastic free shear layers. Through this shear layer stabilization, the viscoelastic far wake is then subject to the same instability mechanisms which dominate for Newtonian flows, but at far lower Reynolds numbers. © Copyright Cambridge University Press 2012.
Yamamoto, Yoshinobu; Kunugi, Tomoaki
2015-01-01
Graphical abstract: - Highlights: • For the first time, the MHD heat transfer DNS database corresponding to the typical nondimensional parameters of the fusion blanket design using molten salt, were established. • MHD heat transfer correlation was proposed and about 20% of the heat transfer degradation was evaluated under the design conditions. • The contribution of the turbulent diffusion to heat transfer is increased drastically with increasing Hartmann number. - Abstract: The high-Prandtl number passive scalar transport of the turbulent channel flow imposed a wall-normal magnetic field is investigated through the large-scale direct numerical simulation (DNS). All essential turbulence scales of velocities and temperature are resolved by using 2048 × 870 × 1024 computational grid points in stream, vertical, and spanwise directions. The heat transfer phenomena for a Prandtl number of 25 were observed under the following flow conditions: the bulk Reynolds number of 14,000 and Hartman number of up to 28. These values were equivalent to the typical nondimensional parameters of the fusion blanket design proposed by Wong et al. As a result, a high-accuracy DNS database for the verification of magnetohydrodynamic turbulent heat transfer models was established for the first time, and it was confirmed that the heat transfer correlation for a Prandtl number of 5.25 proposed by Yamamoto and Kunugi was applicable to the Prandtl number of 25 used in this study
Yamamoto, Yoshinobu, E-mail: yamamotoy@yamanashi.ac.jp [Department of Mechanical Systems Engineering, University of Yamanashi, 4-3-11 Takeda, Kofu 400-8511 (Japan); Kunugi, Tomoaki [Department of Nuclear Engineering, Kyoto University Yoshida, Sakyo, Kyoto 606-8501 (Japan)
2015-01-15
Graphical abstract: - Highlights: • For the first time, the MHD heat transfer DNS database corresponding to the typical nondimensional parameters of the fusion blanket design using molten salt, were established. • MHD heat transfer correlation was proposed and about 20% of the heat transfer degradation was evaluated under the design conditions. • The contribution of the turbulent diffusion to heat transfer is increased drastically with increasing Hartmann number. - Abstract: The high-Prandtl number passive scalar transport of the turbulent channel flow imposed a wall-normal magnetic field is investigated through the large-scale direct numerical simulation (DNS). All essential turbulence scales of velocities and temperature are resolved by using 2048 × 870 × 1024 computational grid points in stream, vertical, and spanwise directions. The heat transfer phenomena for a Prandtl number of 25 were observed under the following flow conditions: the bulk Reynolds number of 14,000 and Hartman number of up to 28. These values were equivalent to the typical nondimensional parameters of the fusion blanket design proposed by Wong et al. As a result, a high-accuracy DNS database for the verification of magnetohydrodynamic turbulent heat transfer models was established for the first time, and it was confirmed that the heat transfer correlation for a Prandtl number of 5.25 proposed by Yamamoto and Kunugi was applicable to the Prandtl number of 25 used in this study.
On the Number of Galaxies at High Redshift
Lorenzo Zaninetti
2015-09-01
Full Text Available The number of galaxies at a given flux as a function of the redshift, z, is derived when the z-distance relation is non-standard. In order to compare different models, the same formalism is also applied to the standard cosmology. The observed luminosity function for galaxies of the zCOSMOS catalog at different redshifts is modeled by a new luminosity function for galaxies, which is derived by the truncated beta probability density function. Three astronomical tests, which are the photometric maximum as a function of the redshift for a fixed flux, the mean value of the redshift for a fixed flux, and the luminosity function for galaxies as a function of the redshift, compare the theoretical values of the standard and non-standard model with the observed value. The tests are performed on the FORS Deep Field (FDF catalog up to redshift z = 1.5 and on the zCOSMOS catalog extending beyond z = 4. These three tests show minimal differences between the standard and the non-standard models.
Normalizations of High Taylor Reynolds Number Power Spectra
Puga, Alejandro; Koster, Timothy; Larue, John C.
2014-11-01
The velocity power spectrum provides insight in how the turbulent kinetic energy is transferred from larger to smaller scales. Wind tunnel experiments are conducted where high intensity turbulence is generated by means of an active turbulence grid modeled after Makita's 1991 design (Makita, 1991) as implemented by Mydlarski and Warhaft (M&W, 1998). The goal of this study is to document the evolution of the scaling region and assess the relative collapse of several proposed normalizations over a range of Rλ from 185 to 997. As predicted by Kolmogorov (1963), an asymptotic approach of the slope (n) of the inertial subrange to - 5 / 3 with increasing Rλ is observed. There are three velocity power spectrum normalizations as presented by Kolmogorov (1963), Von Karman and Howarth (1938) and George (1992). Results show that the Von Karman and Howarth normalization does not collapse the velocity power spectrum as well as the Kolmogorov and George normalizations. The Kolmogorov normalization does a good job of collapsing the velocity power spectrum in the normalized high wavenumber range of 0 . 0002 University of California, Irvine Research Fund.
2016-06-23
AFRL-AFOSR-VA-TR-2016-0277 Experimental Investigation of Turbulence-Chemistry Interaction in High- Reynolds -Number Turbulent Partially Premixed...4. TITLE AND SUBTITLE [U] Experimental investigation of turbulence-chemistry interaction in high- Reynolds -number 5a. CONTRACT NUMBER turbulent...for public release Final Report: Experimental investigation of turbulence-chemistry interaction in high- Reynolds -number turbulent partially premixed
High-Reynolds Number Viscous Flow Simulations on Embedded-Boundary Cartesian Grids
2016-05-05
AFRL-AFOSR-VA-TR-2016-0192 High- Reynolds Number Viscous Flow Simulations on Embedded-Boundary Cartesian Grids Marsha Berger NEW YORK UNIVERSITY Final...TO THE ABOVE ORGANIZATION. 1. REPORT DATE (DD-MM-YYYY) 30/04/2016 2. REPORT TYPE Final 3. DATES COVERED (From - To) High- Reynolds 4. TITLE AND...SUBTITLE High- Reynolds Number Viscous Flow Simulations on Embedded-Boundary Cartesian Grids 5a. CONTRACT NUMBER 5b. GRANT NUMBER FA9550-13-1
Radiation Build-Up Of High Energy Gamma In Shielding Of High Atomic Number
Yuliati, Helfi; Akhadi, Mukhlis
2000-01-01
Research to observe effect of radiation build-up factor (b) in iron (Fe) and lead (Pb) for high energy gamma shielding from exp.137 Cs (E gamma : 662 keV) and exp.60 Co (E gamma : 1332 keV) sources has been carried out. Research was conducted bt counting of radiation intensity behind shielding with its thickness vary from 1 to 5 times of half value thickness (HVT). NaI (TI) detector which connected to multi channel analyzer (MCA) was used for the counting. Calculation result show that all of b value are near to 1 (b∼1) both for Fe and Pb. Without inserting b in calculation, from the experiment it was obtained HVT value of Fe for high gamma radiation of 662 and 1332 keV were : (12,94 n 0,03) mm and (17,33 n 0,01) mm with their deviation standards were 0,2% and 0,06% respectively. Value of HVT for Pb with the same energy were : (6,31 n 0,03) mm and (11,86 n 0,03) mm with their deviation standars were : 0,48% and 0,25% respectively. HVL concept could be applied directly to estimate shielding thickness of high atomic number of high energy gamma radiation, without inserting correction of radiation build-up factor
Effects of rocket jet on stability and control at high Mach numbers
Fetterman, David E , Jr
1958-01-01
Paper presents the results of an investigation to determine the jet-interference effects which may occur at high jet static-pressure ratios and high Mach numbers. Tests were made in the Langley 11-inch hypersonic tunnel at a Mach number of 6.86.
Irrecoverable pressure loss coefficients for two out-of-plane piping elbows at high Reynolds number
Coffield, R.D.; Hammond, R.B.; McKeown, P.T.
1999-02-08
Pressure drops of multiple piping elbows were experimentally determined for high Reynolds number flows. The testing described has been performed in order to reduce uncertainties in the currently used methods for predicting irrecoverable pressure losses and also to provide a qualification database for computational fluid dynamics (CFD) computer codes. The earlier high Reynolds number correlations had been based on extrapolations over several orders of magnitude in Reynolds number from where the original database existed. Recent single elbow test data shows about a factor of two lower elbow pressure loss coefficient (at 40x 106 Reynolds number) than those from current correlations. This single piping elbow data has been extended in this study to a multiple elbow configuration of two elbows that are 90o out-of-plane relative to each other. The effects of separation distance and Reynolds number have been correlated and presented in a form that can be used for design application. Contrary to earlier extrapolations from low Reynolds numbers (Re c 1.0x 106), a strong Reynolds number dependence was found to exist. The combination of the high Reynolds number single elbow data with the multiple elbow interaction effects measured in this study shows that earlier design correlations are conservative by significant margins at high Reynolds numbers. Qualification of CFD predictions with this new high Reynolds number database will help guide the need for additional high Reynolds number testing of other piping configurations. The study also included velocity measurements at several positions downstream of the first and second test elbows using an ultrasonic flowmeter. Reasonable agreement after the first test elbow was found relative to flow fields that are known to exist from low Reynolds number visual tests and also from CFD predictions. This data should help to qualify CFD predictions of the three-dimensional flow stream downstream of the second test elbow.
Excitation of high numbers harmonics by flows of oscillators in a periodic potential
Buts, V.A.; Marekha, V.I.; Tolstoluzhsky, A.P.
2005-01-01
It is shown that the maximum of radiation spectrum of nonrelativistic oscillators, which move into a periodically inhomogeneous potential, can be in the region of high numbers harmonics. Spectrum of such oscillators radiation becomes similar to the radiation spectrum of relativistic oscillators. The equations, describing the non-linear self-consistent theory of excitations, of high numbers harmonics by ensemble of oscillators are formulated and its numerical analysis is conducted. The numerical analysis has confirmed the capability of radiation of high numbers of harmonics. Such peculiarity of radiation allows t expect of creation of nonrelativistic FEL
Trading volume and the number of trades : a comparative study using high frequency data
Izzeldin, Marwan
2007-01-01
Trading volume and the number of trades are both used as proxies for market activity, with disagreement as to which is the better proxy for market activity. This paper investigates this issue using high frequency data for Cisco and Intel in 1997. A number of econometric methods are used, including GARCH augmented with lagged trading volume and number of trades, tests based on moment restrictions, regression analysis of volatility on volume and trades, normality of returns when standardized by...
The Effects of Number Theory Study on High School Students' Metacognition and Mathematics Attitudes
Miele, Anthony M.
2014-01-01
The purpose of this study was to determine how the study of number theory might affect high school students' metacognitive functioning, mathematical curiosity, and/or attitudes towards mathematics. The study utilized questionnaire and/or interview responses of seven high school students from New York City and 33 high school students from Dalian,…
Armour, J.A.; Palla, R.; Zeeuwen, P.L.J.M.; Heijer, M. den; Schalkwijk, J.; Hollox, E.J.
2007-01-01
Recent work has demonstrated an unexpected prevalence of copy number variation in the human genome, and has highlighted the part this variation may play in predisposition to common phenotypes. Some important genes vary in number over a high range (e.g. DEFB4, which commonly varies between two and
PCR cycles above routine numbers do not compromise high-throughput DNA barcoding results.
Vierna, J; Doña, J; Vizcaíno, A; Serrano, D; Jovani, R
2017-10-01
High-throughput DNA barcoding has become essential in ecology and evolution, but some technical questions still remain. Increasing the number of PCR cycles above the routine 20-30 cycles is a common practice when working with old-type specimens, which provide little amounts of DNA, or when facing annealing issues with the primers. However, increasing the number of cycles can raise the number of artificial mutations due to polymerase errors. In this work, we sequenced 20 COI libraries in the Illumina MiSeq platform. Libraries were prepared with 40, 45, 50, 55, and 60 PCR cycles from four individuals belonging to four species of four genera of cephalopods. We found no relationship between the number of PCR cycles and the number of mutations despite using a nonproofreading polymerase. Moreover, even when using a high number of PCR cycles, the resulting number of mutations was low enough not to be an issue in the context of high-throughput DNA barcoding (but may still remain an issue in DNA metabarcoding due to chimera formation). We conclude that the common practice of increasing the number of PCR cycles should not negatively impact the outcome of a high-throughput DNA barcoding study in terms of the occurrence of point mutations.
High-mode-number ballooning modes in a heliotron/torsatron system. II. Stability
Nakajima, N.
1996-01-01
In heliotron/torsatron systems that have a large Shafranov shift, the local magnetic shear is found to have no stabilizing effect on high-mode-number ballooning modes at the outer side of the torus, even in the region where the global shear is stellarator-like in nature. The disappearance of this stabilization, in combination with the compression of the flux surfaces at the outer side of the torus, leads at relatively low values of the plasma pressure to significant modifications of the stabilizing effect due to magnetic field-line bending on high-mode-number ballooning modes-specifically, that the field-line bending stabilization can be remarkably suppressed or enhanced. In an equilibrium that is slightly Mercier-unstable or completely Mercier-stable due to peaked pressure profiles, such as those used in standard stability calculations, high-mode-number ballooning modes are destabilized due to these modified stability effects, with their eigenfunctions highly localized along the field line. Highly localized mode structures such as these cause the ballooning mode eigenvalues ω 2 to have a strong field line dependence (i.e., α-variation) through the strong dependence of the local magnetic curvature, such that the level surfaces of ω 2 (ψ,θ k ,α) (≤0) become spheroids in (ψ,θ k ,α) space, where ψ labels flux surfaces and θ k is the radial wave number. Because the spheroidal level surfaces for unstable eigenvalues are surrounded by level surfaces for stable eigenvalues of high-mode-number toroidal Alfvacute en eigenmodes, those high-mode-number ballooning modes never lead to low-mode-number modes. In configuration space, these high-mode-number modes are localized in a single toroidal pitch of the helical coils, and hence they may experience substantial stabilization due to finite Larmor radius effects. copyright 1996 American Institute of Physics
A note on high Schmidt number laminar buoyant jets discharged horizontally
Dewan, A.; Arakeri, J.H.; Srinivasan, J.
1992-01-01
This paper reports on a new model, developed for the integral analysis of high Schmidt number (or equivalently high Prandtl number) laminar buoyant jets discharged horizontally. This model assumes top-hat density profile across the inner core of jet and Gaussian velocity profile. Entrainment coefficient corresponding to pure laminar jet has been taken in the analysis. The prediction of the jet trajectory agree well with experimental data in the regions where the jet remains laminar
Hybrid RANS/LES method for high Reynolds numbers, applied to atmospheric flow over complex terrain
Bechmann, Andreas; Sørensen, Niels N.; Johansen, Jeppe
2007-01-01
The use of Large-Eddy Simulation (LES) to predict wall-bounded flows has presently been limited to low Reynolds number flows. Since the number of computational grid points required to resolve the near-wall turbulent structures increase rapidly with Reynolds number, LES has been unattainable...... for flows at high Reynolds numbers. To reduce the computational cost of traditional LES a hybrid method is proposed in which the near-wall eddies are modelled in a Reynolds-averaged sense. Close to walls the flow is treated with the RANS-equations and this layer act as wall model for the outer flow handled...... by LES. The wellknown high Reynolds number two-equation k - ǫ turbulence model is used in the RANS layer and the model automatically switches to a two-equation k - ǫ subgrid-scale stress model in the LES region. The approach can be used for flow over rough walls. To demonstrate the ability...
Multigrid solution of the convection-diffusion equation with high-Reynolds number
Zhang, Jun [George Washington Univ., Washington, DC (United States)
1996-12-31
A fourth-order compact finite difference scheme is employed with the multigrid technique to solve the variable coefficient convection-diffusion equation with high-Reynolds number. Scaled inter-grid transfer operators and potential on vectorization and parallelization are discussed. The high-order multigrid method is unconditionally stable and produces solution of 4th-order accuracy. Numerical experiments are included.
Klewicki, J C; Chini, G P; Gibson, J F
2017-03-13
Recent and on-going advances in mathematical methods and analysis techniques, coupled with the experimental and computational capacity to capture detailed flow structure at increasingly large Reynolds numbers, afford an unprecedented opportunity to develop realistic models of high Reynolds number turbulent wall-flow dynamics. A distinctive attribute of this new generation of models is their grounding in the Navier-Stokes equations. By adhering to this challenging constraint, high-fidelity models ultimately can be developed that not only predict flow properties at high Reynolds numbers, but that possess a mathematical structure that faithfully captures the underlying flow physics. These first-principles models are needed, for example, to reliably manipulate flow behaviours at extreme Reynolds numbers. This theme issue of Philosophical Transactions of the Royal Society A provides a selection of contributions from the community of researchers who are working towards the development of such models. Broadly speaking, the research topics represented herein report on dynamical structure, mechanisms and transport; scale interactions and self-similarity; model reductions that restrict nonlinear interactions; and modern asymptotic theories. In this prospectus, the challenges associated with modelling turbulent wall-flows at large Reynolds numbers are briefly outlined, and the connections between the contributing papers are highlighted.This article is part of the themed issue 'Toward the development of high-fidelity models of wall turbulence at large Reynolds number'. © 2017 The Author(s).
Advanced lattice Boltzmann scheme for high-Reynolds-number magneto-hydrodynamic flows
De Rosis, Alessandro; Lévêque, Emmanuel; Chahine, Robert
2018-06-01
Is the lattice Boltzmann method suitable to investigate numerically high-Reynolds-number magneto-hydrodynamic (MHD) flows? It is shown that a standard approach based on the Bhatnagar-Gross-Krook (BGK) collision operator rapidly yields unstable simulations as the Reynolds number increases. In order to circumvent this limitation, it is here suggested to address the collision procedure in the space of central moments for the fluid dynamics. Therefore, an hybrid lattice Boltzmann scheme is introduced, which couples a central-moment scheme for the velocity with a BGK scheme for the space-and-time evolution of the magnetic field. This method outperforms the standard approach in terms of stability, allowing us to simulate high-Reynolds-number MHD flows with non-unitary Prandtl number while maintaining accuracy and physical consistency.
Jensen, Michael Vincent; Walther, Jens Honore
2013-01-01
was investigated at a jet Reynolds number of 1.66 × 105 and a temperature difference between jet inlet and wall of 1600 K. The focus was on the convective heat transfer contribution as thermal radiation was not included in the investigation. A considerable influence of the turbulence intensity at the jet inlet...... to about 100% were observed. Furthermore, the variation in stagnation point heat transfer was examined for jet Reynolds numbers in the range from 1.10 × 105 to 6.64 × 105. Based on the investigations, a correlation is suggested between the stagnation point Nusselt number, the jet Reynolds number......, and the turbulence intensity at the jet inlet for impinging jet flows at high jet Reynolds numbers. Copyright © 2013 Taylor and Francis Group, LLC....
High-Performance Pseudo-Random Number Generation on Graphics Processing Units
Nandapalan, Nimalan; Brent, Richard P.; Murray, Lawrence M.; Rendell, Alistair
2011-01-01
This work considers the deployment of pseudo-random number generators (PRNGs) on graphics processing units (GPUs), developing an approach based on the xorgens generator to rapidly produce pseudo-random numbers of high statistical quality. The chosen algorithm has configurable state size and period, making it ideal for tuning to the GPU architecture. We present a comparison of both speed and statistical quality with other common parallel, GPU-based PRNGs, demonstrating favourable performance o...
On the motion of non-spherical particles at high Reynolds number
Mandø, Matthias; Rosendahl, Lasse
2010-01-01
This paper contains a critical review of available methodology for dealing with the motion of non-spherical particles at higher Reynolds numbers in the Eulerian- Lagrangian methodology for dispersed flow. First, an account of the various attempts to classify the various shapes and the efforts...... motion it is necessary to account for the non-coincidence between the center of pressure and center of gravity which is a direct consequence of the inertial pressure forces associated with particles at high Reynolds number flow. Extensions for non-spherical particles at higher Reynolds numbers are far...
Active Control of Flow Separation on a High-Lift System with Slotted Flap at High Reynolds Number
Khodadoust, Abdollah; Washburn, Anthony
2007-01-01
The NASA Energy Efficient Transport (EET) airfoil was tested at NASA Langley's Low- Turbulence Pressure Tunnel (LTPT) to assess the effectiveness of distributed Active Flow Control (AFC) concepts on a high-lift system at flight scale Reynolds numbers for a medium-sized transport. The test results indicate presence of strong Reynolds number effects on the high-lift system with the AFC operational, implying the importance of flight-scale testing for implementation of such systems during design of future flight vehicles with AFC. This paper describes the wind tunnel test results obtained at the LTPT for the EET high-lift system for various AFC concepts examined on this airfoil.
ITER-W monoblocks under high pulse number transient heat loads at high temperature
Loewenhoff, Th.; Linke, J.; Pintsuk, G.; Pitts, R.A.; Riccardi, B.
2015-01-01
In the context of using a full-tungsten (W) divertor for ITER, thermal shock resistance has become even more important as an issue that may potentially influence the long term performance. To address this issue a unique series of experiments has been performed on ITER-W monoblock mock ups in three EU high heat flux facilities: GLADIS (neutral beam), JUDITH 2 (electron beam) and Magnum-PSI (plasma beam). This paper discusses the JUDITH 2 experiments. Two different base temperatures, 1200 °C and 1500 °C, were chosen superimposed by ∼18,000/100,000 transient events (Δt = 0.48 ms) of 0.2 and 0.6 GW/m 2 . Results showed a stronger surface deterioration at higher base temperature, quantified by an increase in roughening. This is intensified if the same test is done after preloading (exposure to high temperature without transients), especially at higher base temperature when the material recrystallizes
Quadruplex MAPH: improvement of throughput in high-resolution copy number screening.
Tyson, Jess; Majerus, Tamsin Mo; Walker, Susan; Armour, John Al
2009-09-28
Copy number variation (CNV) in the human genome is recognised as a widespread and important source of human genetic variation. Now the challenge is to screen for these CNVs at high resolution in a reliable, accurate and cost-effective way. Multiplex Amplifiable Probe Hybridisation (MAPH) is a sensitive, high-resolution technology appropriate for screening for CNVs in a defined region, for a targeted population. We have developed MAPH to a highly multiplexed format ("QuadMAPH") that allows the user a four-fold increase in the number of loci tested simultaneously. We have used this method to analyse a genomic region of 210 kb, including the MSH2 gene and 120 kb of flanking DNA. We show that the QuadMAPH probes report copy number with equivalent accuracy to simplex MAPH, reliably demonstrating diploid copy number in control samples and accurately detecting deletions in Hereditary Non-Polyposis Colorectal Cancer (HNPCC) samples. QuadMAPH is an accurate, high-resolution method that allows targeted screening of large numbers of subjects without the expense of genome-wide approaches. Whilst we have applied this technique to a region of the human genome, it is equally applicable to the genomes of other organisms.
Klewicki, J. C.; Chini, G. P.; Gibson, J. F.
2017-01-01
Recent and on-going advances in mathematical methods and analysis techniques, coupled with the experimental and computational capacity to capture detailed flow structure at increasingly large Reynolds numbers, afford an unprecedented opportunity to develop realistic models of high Reynolds number turbulent wall-flow dynamics. A distinctive attribute of this new generation of models is their grounding in the Navier–Stokes equations. By adhering to this challenging constraint, high-fidelity models ultimately can be developed that not only predict flow properties at high Reynolds numbers, but that possess a mathematical structure that faithfully captures the underlying flow physics. These first-principles models are needed, for example, to reliably manipulate flow behaviours at extreme Reynolds numbers. This theme issue of Philosophical Transactions of the Royal Society A provides a selection of contributions from the community of researchers who are working towards the development of such models. Broadly speaking, the research topics represented herein report on dynamical structure, mechanisms and transport; scale interactions and self-similarity; model reductions that restrict nonlinear interactions; and modern asymptotic theories. In this prospectus, the challenges associated with modelling turbulent wall-flows at large Reynolds numbers are briefly outlined, and the connections between the contributing papers are highlighted. This article is part of the themed issue ‘Toward the development of high-fidelity models of wall turbulence at large Reynolds number’. PMID:28167585
Quadruplex MAPH: improvement of throughput in high-resolution copy number screening
Walker Susan
2009-09-01
Full Text Available Abstract Background Copy number variation (CNV in the human genome is recognised as a widespread and important source of human genetic variation. Now the challenge is to screen for these CNVs at high resolution in a reliable, accurate and cost-effective way. Results Multiplex Amplifiable Probe Hybridisation (MAPH is a sensitive, high-resolution technology appropriate for screening for CNVs in a defined region, for a targeted population. We have developed MAPH to a highly multiplexed format ("QuadMAPH" that allows the user a four-fold increase in the number of loci tested simultaneously. We have used this method to analyse a genomic region of 210 kb, including the MSH2 gene and 120 kb of flanking DNA. We show that the QuadMAPH probes report copy number with equivalent accuracy to simplex MAPH, reliably demonstrating diploid copy number in control samples and accurately detecting deletions in Hereditary Non-Polyposis Colorectal Cancer (HNPCC samples. Conclusion QuadMAPH is an accurate, high-resolution method that allows targeted screening of large numbers of subjects without the expense of genome-wide approaches. Whilst we have applied this technique to a region of the human genome, it is equally applicable to the genomes of other organisms.
Flooding-limited thermal mixing: The case of high-froude number injection
Iyer, K.; Theofanous, T.G.
1985-01-01
The stratification in the cold leg due to high pressure injection in a stagnated loop of a PWR is considered. The working hypothesis is that at high injection Froude numbers the extent of mixing approaches a limit controlled only by the flooding condition at the cold leg exit. The available experimental data support this hypothesis. Predictions for reactor conditions indicate a stratification of about --40 0 C. As a consequence, the downcomer plume would be rather weak (low Froude Number) and is expected to decay quickly
Unsuppressed fermion-number violation at high temperature: An O(3) model
Mottola, E.; Wipf, A.
1989-01-01
The O(3) nonlinear σ model in 1+1 dimensions, modified by an explicit symmetry-breaking term, is presented as a model for baryon- and lepton-number violation in the standard electroweak theory. Although arguments based on the Atiyah-Singer index theorem and instanton physics apply to the model, we show by explicit calculations that the rate of chiral fermion-number violation due to the axial anomaly is entirely unsuppressed at sufficiently high temperatures. Our results apply to unbroken gauge theories as well and may require reevaluation of the role of instantons in high-temperature QCD
Estimating the numbers of malaria infections in blood samples using high-resolution genotyping data.
Amanda Ross
Full Text Available People living in endemic areas often habour several malaria infections at once. High-resolution genotyping can distinguish between infections by detecting the presence of different alleles at a polymorphic locus. However the number of infections may not be accurately counted since parasites from multiple infections may carry the same allele. We use simulation to determine the circumstances under which the number of observed genotypes are likely to be substantially less than the number of infections present and investigate the performance of two methods for estimating the numbers of infections from high-resolution genotyping data. The simulations suggest that the problem is not substantial in most datasets: the disparity between the mean numbers of infections and of observed genotypes was small when there was 20 or more alleles, 20 or more blood samples, a mean number of infections of 6 or less and where the frequency of the most common allele was no greater than 20%. The issue of multiple infections carrying the same allele is unlikely to be a major component of the errors in PCR-based genotyping. Simulations also showed that, with heterogeneity in allele frequencies, the observed frequencies are not a good approximation of the true allele frequencies. The first method that we proposed to estimate the numbers of infections assumes that they are a good approximation and hence did poorly in the presence of heterogeneity. In contrast, the second method by Li et al estimates both the numbers of infections and the true allele frequencies simultaneously and produced accurate estimates of the mean number of infections.
Sigg, K. C.; Coffield, R. D.
2002-09-01
High Reynolds number test data has recently been reported for both single and multiple piping elbow design configurations at earlier ASME Fluid Engineering Division conferences. The data of these studies ranged up to a Reynolds number of 42 x 10[sup]6 which is significantly greater than that used to establish design correlations before the data was available. Many of the accepted design correlations, based on the lower Reynolds number data, date back as much as fifty years. The new data shows that these earlier correlations are extremely conservative for high Reynolds number applications. Based on the recent high Reynolds number information a new recommended method has been developed for calculating irrecoverable pressure loses in piping systems for design considerations such as establishing pump sizing requirements. This paper describes the recommended design approach and additional testing that has been performed as part of the qualification of the method. This qualification testing determined the irrecoverable pressure loss of a piping configuration that would typify a limiting piping section in a complicated piping network, i.e., multiple, tightly coupled, out-of-plane elbows in series under high Reynolds number flow conditions. The overall pressure loss measurements were then compared to predictions, which used the new methodology to assure that conservative estimates for the pressure loss (of the type used for pump sizing) were obtained. The recommended design methodology, the qualification testing and the comparison between the predictions and the test data are presented. A major conclusion of this study is that the recommended method for calculating irrecoverable pressure loss in piping systems is conservative yet significantly lower than predicted by early design correlations that were based on the extrapolation of low Reynolds number test data.
Armour, John A L; Palla, Raquel; Zeeuwen, Patrick L J M; den Heijer, Martin; Schalkwijk, Joost; Hollox, Edward J
2007-01-01
Recent work has demonstrated an unexpected prevalence of copy number variation in the human genome, and has highlighted the part this variation may play in predisposition to common phenotypes. Some important genes vary in number over a high range (e.g. DEFB4, which commonly varies between two and seven copies), and have posed formidable technical challenges for accurate copy number typing, so that there are no simple, cheap, high-throughput approaches suitable for large-scale screening. We have developed a simple comparative PCR method based on dispersed repeat sequences, using a single pair of precisely designed primers to amplify products simultaneously from both test and reference loci, which are subsequently distinguished and quantified via internal sequence differences. We have validated the method for the measurement of copy number at DEFB4 by comparison of results from >800 DNA samples with copy number measurements by MAPH/REDVR, MLPA and array-CGH. The new Paralogue Ratio Test (PRT) method can require as little as 10 ng genomic DNA, appears to be comparable in accuracy to the other methods, and for the first time provides a rapid, simple and inexpensive method for copy number analysis, suitable for application to typing thousands of samples in large case-control association studies.
High-speed true random number generation based on paired memristors for security electronics
Zhang, Teng; Yin, Minghui; Xu, Changmin; Lu, Xiayan; Sun, Xinhao; Yang, Yuchao; Huang, Ru
2017-11-01
True random number generator (TRNG) is a critical component in hardware security that is increasingly important in the era of mobile computing and internet of things. Here we demonstrate a TRNG using intrinsic variation of memristors as a natural source of entropy that is otherwise undesirable in most applications. The random bits were produced by cyclically switching a pair of tantalum oxide based memristors and comparing their resistance values in the off state, taking advantage of the more pronounced resistance variation compared with that in the on state. Using an alternating read scheme in the designed TRNG circuit, the unbiasedness of the random numbers was significantly improved, and the bitstream passed standard randomness tests. The Pt/TaO x /Ta memristors fabricated in this work have fast programming/erasing speeds of ˜30 ns, suggesting a high random number throughput. The approach proposed here thus holds great promise for physically-implemented random number generation.
Miyoshi, Takahiro; Becchaku, Masahiro; Kusano, Kanya
2008-01-01
Nonlinear dynamics of the resistive tearing instability in high magnetic Reynolds number (R m ) plasmas is studied by newly developing an accurate and robust resistive magnetohydrodynamic (MHD) scheme. The results show that reconnection processes strongly depend on R m . Particularly, in a high R m case, small-scale plasmoids induced by a secondary instability are intermittently generated and ejected accompanied by fast shocks. According to the intermittent processes, the reconnection rate increases intermittently at a later nonlinear stage. (author)
A comparative study of near-wall turbulence in high and low Reynolds number boundary layers
Metzger, M.M.; Klewicki, J.C.
2001-01-01
The present study explores the effects of Reynolds number, over three orders of magnitude, in the viscous wall region of a turbulent boundary layer. Complementary experiments were conducted both in the boundary layer wind tunnel at the University of Utah and in the atmospheric surface layer which flows over the salt flats of the Great Salt Lake Desert in western Utah. The Reynolds numbers, based on momentum deficit thickness, of the two flows were R θ =2x10 3 and R θ ≅5x10 6 , respectively. High-resolution velocity measurements were obtained from a five-element vertical rake of hot-wires spanning the buffer region. In both the low and high R θ flows, the length of the hot-wires measured less than 6 viscous units. To facilitate reliable comparisons, both the laboratory and field experiments employed the same instrumentation and procedures. Data indicate that, even in the immediate vicinity of the surface, strong influences from low-frequency motions at high R θ produce noticeable Reynolds number differences in the streamwise velocity and velocity gradient statistics. In particular, the peak value in the root mean square streamwise velocity profile, when normalized by viscous scales, was found to exhibit a logarithmic dependence on Reynolds number. The mean streamwise velocity profile, on the other hand, appears to be essentially independent of Reynolds number. Spectra and spatial correlation data suggest that low-frequency motions at high Reynolds number engender intensified local convection velocities which affect the structure of both the velocity and velocity gradient fields. Implications for turbulent production mechanisms and coherent motions in the buffer layer are discussed
Henneberry, Hugh M.; Snyder, Christopher A.
1993-01-01
An analysis of gas turbine engines using water and oxygen injection to enhance performance by increasing Mach number capability and by increasing thrust is described. The liquids are injected, either separately or together, into the subsonic diffuser ahead of the engine compressor. A turbojet engine and a mixed-flow turbofan engine (MFTF) are examined, and in pursuit of maximum thrust, both engines are fitted with afterburners. The results indicate that water injection alone can extend the performance envelope of both engine types by one and one-half Mach numbers at which point water-air ratios reach 17 or 18 percent and liquid specific impulse is reduced to some 390 to 470 seconds, a level about equal to the impulse of a high energy rocket engine. The envelope can be further extended, but only with increasing sacrifices in liquid specific impulse. Oxygen-airflow ratios as high as 15 percent were investigated for increasing thrust. Using 15 percent oxygen in combination with water injection at high supersonic Mach numbers resulted in thrust augmentation as high as 76 percent without any significant decrease in liquid specific impulse. The stoichiometric afterburner exit temperature increased with increasing oxygen flow, reaching 4822 deg R in the turbojet engine at a Mach number of 3.5. At the transonic Mach number of 0.95 where no water injection is needed, an oxygen-air ratio of 15 percent increased thrust by some 55 percent in both engines, along with a decrease in liquid specific impulse of 62 percent. Afterburner temperature was approximately 4700 deg R at this high thrust condition. Water and/or oxygen injection are simple and straightforward strategies to improve engine performance and they will add little to engine weight. However, if large Mach number and thrust increases are required, liquid flows become significant, so that operation at these conditions will necessarily be of short duration.
Baryon-plus-lepton number violation at high temperatures for arbitrary Higgs mass
Li, Xu.
1992-01-01
In this thesis, baryon-plus lepton (B + L) number violation in the electroweak theory of the Weinberg-Salam model is systematically studied. B + L number non-conservation in the electroweak theory is believed to be a consequence of the axial U(1) anomaly. It is argued that sphaleron, not instanton dominates the topological vacuum-to-vacuum transitions for B + L number change at high temperatures. The rate of change is reduced to a dimensionless prefactor κ which is related to the determinants of small fluctuations around the sphaleron configuration. And κ is exactly computed at high temperatures exploiting symmetries of sphaleron under spatial rotations combined with isospin and custodial SU(2) transformations. For the ratio λ/g 2 of scalar four point coupling λ to gauge coupling g 2 near unity, it is found that κ is 0.03 and the rate of B + L number change at temperatures of order 1 Tev is about 8 to 9 orders of magnitude faster than the expansion rate of the big band theory. For λ/g 2 very small tending to the Coleman-Weinberg limit, it is found that the determinant strongly suppresses the rate of baryon number changing processes
Mass transfer in wetted-wall columns: correlations at high Reynolds numbers
Nielsen, Christian H.E.; Kiil, Søren; Thomsen, Henrik W.
1998-01-01
(G)) were determined. In dimensionless form, the correlations are given by Sh(L) = 0.01613 Re-G(0.664) Re-L(0.426) Sc-L(0.5) Sh(G) = 0.00031 Re-G(1.05) Re-L(0.207) Sc-G(0.5) and are valid at gas-phase Reynolds numbers from 7500 to 18,300 and liquid-phase Reynolds numbers from 4000 to 12,000, conditions...... of industrial relevance. To our knowledge, no correlations for Sh(G) have been reported in the literature which are valid at such high Reynolds numbers. The wetted-wall column was equipped with six intermediate measuring positions for gas and two for liquid samples, giving rise to a high accuracy...... of the obtained correlations. Our data showed that Sh(L) and Sh(G) both depend on Re-G and Re-L due to changes in the interfacial area at the high Reynolds numbers employed. The presence of inert particles in the liquid-phase may influence the rate of mass transport, and experimental work was initiated to study...
2010-01-01
high-speed flows is problematic due to their low forcing frequency (for mechanical actuators) and low forcing amplitude (for piezo actuators...very low fraction of DC power is coupled to the actuators (5-10%), with the rest of the power dissipated in massive ballast resistors acting as heat... resistors . The use of high-power resistors also significantly increases the weight and size of the plasma generator and makes scaling to a large number of
Magnus effects at high angles of attack and critical Reynolds numbers
Seginer, A.; Ringel, M.
1983-01-01
The Magnus force and moment experienced by a yawed, spinning cylinder were studied experimentally in low speed and subsonic flows at high angles of attack and critical Reynolds numbers. Flow-field visualization aided in describing a flow model that divides the Magnus phenomenon into a subcritical region, where reverse Magnus loads are experienced, and a supercritical region where these loads are not encountered. The roles of the spin rate, angle of attack, and crossflow Reynolds number in determining the boundaries of the subcritical region and the variations of the Magnus loads were studied.
Carlos Humberto Galeano Urueña
2009-05-01
Full Text Available This article describes the streamline upwind Petrov-Galerkin (SUPG method as being a stabilisation technique for resolving the diffusion-advection-reaction equation by finite elements. The first part of this article has a short analysis of the importance of this type of differential equation in modelling physical phenomena in multiple fields. A one-dimensional description of the SUPG me- thod is then given to extend this basis to two and three dimensions. The outcome of a strongly advective and a high numerical complexity experiment is presented. The results show how the version of the implemented SUPG technique allowed stabilised approaches in space, even for high Peclet numbers. Additional graphs of the numerical experiments presented here can be downloaded from www.gnum.unal.edu.co.
Turbulent convection experiment at high Rayleigh number to support CAP1400 IVR strategy
Ma, Li, E-mail: mali@snptrd.com [State Nuclear Hua Qing(Beijing) Nuclear Power Technology R& D Centre Co., Ltd, Building A, State Nuclear Power Research Institute, Future Science & Technology Park, Changping Dist., Beijing 102209 (China); Li, Jing, E-mail: lijing@snptrd.com [State Nuclear Hua Qing(Beijing) Nuclear Power Technology R& D Centre Co., Ltd, Building A, State Nuclear Power Research Institute, Future Science & Technology Park, Changping Dist., Beijing 102209 (China); Ji, Shui, E-mail: jishui@snptrd.com [State Nuclear Hua Qing(Beijing) Nuclear Power Technology R& D Centre Co., Ltd, Building A, State Nuclear Power Research Institute, Future Science & Technology Park, Changping Dist., Beijing 102209 (China); Chang, Huajian, E-mail: changhuajian@snptrd.com [State Nuclear Hua Qing(Beijing) Nuclear Power Technology R& D Centre Co., Ltd, Building A, State Nuclear Power Research Institute, Future Science & Technology Park, Changping Dist., Beijing 102209 (China); Institute of Nuclear and New Energy Technology, Tsinghua University, Beijing 100084 (China)
2015-10-15
Highlights: • The facility reached high Ra number at 10{sup 12} of CAP1400 working condition. • The fitting formula Nu = 0.085 × Ra{sup 0.315} was established to calculate the heat flux in the metal layer at high Ra for the CAP1400. • The coupling method can accurately and safely predict the heat flow distribution of metal layer in high Ra number conditions. • The experiment results will predict the relationship between axial and radial heat transfer well. - Abstract: The characteristics of the heat transfer and the calculation of heat flux in metal layer are both the critical problems for in-vessel retention (IVR) strategy. Turbulent convection occurs in the metal layer when the Rayleigh number (Ra) becomes sufficient high. The Globe–Dropkin (G–D) correlation (Globe and Dropkin, 1959) and Chu–Churchill (C–C) correlation (Churchill and Chu, 1975) have been widely used to calculate the heat flux in the metal layer, where the valid range of the Ra is from 1.5 × 10{sup 5} to 6.8 × 10{sup 8} in G–D correlation and less than 10{sup 12} in C–C correlation. However, with the increase of reactor power, both the Rayleigh number and the rate of heat transfer below the bottom of metal layer of the molten pool will increase, and in this case the Rayleigh number even can reach 10{sup 11} for the China Advanced Passive Plant CAP1400. Accordingly, the G–D correlation is not suitable for the CAP1400. Therefore, our experiment purposes are to establish the appropriate correlation at high Ra for the CAP1400 and predict the axial and radial distribution of the heat transfer in the metal layer with the heat transfer behavior of metal layer experiment (HELM) facility. The experiments are divided into two parts. Each part concerns 39 runs and 47 experimental conditions. Its corresponding results are obtained at middle Prandtl number (Pr = 7 for water) and the Nusselt number is found to be proportional to Ra{sup 0.315} in the range 3.93 × 10{sup 8} < Ra < 3.57
Turbulent convection experiment at high Rayleigh number to support CAP1400 IVR strategy
Ma, Li; Li, Jing; Ji, Shui; Chang, Huajian
2015-01-01
Highlights: • The facility reached high Ra number at 10 12 of CAP1400 working condition. • The fitting formula Nu = 0.085 × Ra 0.315 was established to calculate the heat flux in the metal layer at high Ra for the CAP1400. • The coupling method can accurately and safely predict the heat flow distribution of metal layer in high Ra number conditions. • The experiment results will predict the relationship between axial and radial heat transfer well. - Abstract: The characteristics of the heat transfer and the calculation of heat flux in metal layer are both the critical problems for in-vessel retention (IVR) strategy. Turbulent convection occurs in the metal layer when the Rayleigh number (Ra) becomes sufficient high. The Globe–Dropkin (G–D) correlation (Globe and Dropkin, 1959) and Chu–Churchill (C–C) correlation (Churchill and Chu, 1975) have been widely used to calculate the heat flux in the metal layer, where the valid range of the Ra is from 1.5 × 10 5 to 6.8 × 10 8 in G–D correlation and less than 10 12 in C–C correlation. However, with the increase of reactor power, both the Rayleigh number and the rate of heat transfer below the bottom of metal layer of the molten pool will increase, and in this case the Rayleigh number even can reach 10 11 for the China Advanced Passive Plant CAP1400. Accordingly, the G–D correlation is not suitable for the CAP1400. Therefore, our experiment purposes are to establish the appropriate correlation at high Ra for the CAP1400 and predict the axial and radial distribution of the heat transfer in the metal layer with the heat transfer behavior of metal layer experiment (HELM) facility. The experiments are divided into two parts. Each part concerns 39 runs and 47 experimental conditions. Its corresponding results are obtained at middle Prandtl number (Pr = 7 for water) and the Nusselt number is found to be proportional to Ra 0.315 in the range 3.93 × 10 8 < Ra < 3.57 × 10 12 . Furthermore, the experiment
The Dynamics of Very High Alfvén Mach Number Shocks in Space Plasmas
Sundberg, Torbjörn; Burgess, David [School of Physics and Astronomy, Queen Mary University of London, London, E1 4NS (United Kingdom); Scholer, Manfred [Max-Planck-Institut für extraterrestrische Physik, Garching (Germany); Masters, Adam [The Blackett Laboratory, Imperial College London, Prince Consort Road, London, SW7 2AZ (United Kingdom); Sulaiman, Ali H., E-mail: torbjorn.sundberg@gmail.com [Department of Physics and Astronomy, University of Iowa, Iowa City, Iowa 52242 (United States)
2017-02-10
Astrophysical shocks, such as planetary bow shocks or supernova remnant shocks, are often in the high or very-high Mach number regime, and the structure of such shocks is crucial for understanding particle acceleration and plasma heating, as well inherently interesting. Recent magnetic field observations at Saturn’s bow shock, for Alfvén Mach numbers greater than about 25, have provided evidence for periodic non-stationarity, although the details of the ion- and electron-scale processes remain unclear due to limited plasma data. High-resolution, multi-spacecraft data are available for the terrestrial bow shock, but here the very high Mach number regime is only attained on extremely rare occasions. Here we present magnetic field and particle data from three such quasi-perpendicular shock crossings observed by the four-spacecraft Cluster mission. Although both ion reflection and the shock profile are modulated at the upstream ion gyroperiod timescale, the dominant wave growth in the foot takes place at sub-proton length scales and is consistent with being driven by the ion Weibel instability. The observed large-scale behavior depends strongly on cross-scale coupling between ion and electron processes, with ion reflection never fully suppressed, and this suggests a model of the shock dynamics that is in conflict with previous models of non-stationarity. Thus, the observations offer insight into the conditions prevalent in many inaccessible astrophysical environments, and provide important constraints for acceleration processes at such shocks.
Definition and measurement of the times-diffraction-limit number of high-power laser beams
Bollanti, Sarah; Di Lazzaro, Paolo; Murra, Daniele
1998-07-01
A novel definition of the times-diffraction-limit (TDL) number of a laser beam is given. A comparison is made with the commonly used beam-propagation parameter M2, which is unreliable for hard-edge beams, like those produced by unstable resonators with diffraction output coupling. The new suggested TDL number definition doesn't rely on the real beam comparison to a Gaussian beam, but on the comparison of the far-field performances of the real beam with respect to those of a uniphase beam with the same amplitude profile in the near field. A practical method is also given for the estimation of the TDL number of real beams. Finally, this procedure is applied to the high-peak-power laser beams generated by two excimer laser systems developed in ENEA.
Noise-free high-efficiency photon-number-resolving detectors
Rosenberg, Danna; Lita, Adriana E.; Miller, Aaron J.; Nam, Sae Woo
2005-01-01
High-efficiency optical detectors that can determine the number of photons in a pulse of monochromatic light have applications in a variety of physics studies, including post-selection-based entanglement protocols for linear optics quantum computing and experiments that simultaneously close the detection and communication loopholes of Bell's inequalities. Here we report on our demonstration of fiber-coupled, noise-free, photon-number-resolving transition-edge sensors with 88% efficiency at 1550 nm. The efficiency of these sensors could be made even higher at any wavelength in the visible and near-infrared spectrum without resulting in a higher dark-count rate or degraded photon-number resolution
NASA High-Reynolds Number Circulation Control Research - Overview of CFD and Planned Experiments
Milholen, W. E., II; Jones, Greg S.; Cagle, Christopher M.
2010-01-01
A new capability to test active flow control concepts and propulsion simulations at high Reynolds numbers in the National Transonic Facility at the NASA Langley Research Center is being developed. This technique is focused on the use of semi-span models due to their increased model size and relative ease of routing high-pressure air to the model. A new dual flow-path high-pressure air delivery station has been designed, along with a new high performance transonic sem -si pan wing model. The modular wind tunnel model is designed for testing circulation control concepts at both transonic cruise and low-speed high-lift conditions. The ability of the model to test other active flow control techniques will be highlighted. In addition, a new higher capacity semi-span force and moment wind tunnel balance has been completed and calibrated to enable testing at transonic conditions.
Li, Dongfang; Lu, Zhaojun; Zou, Xuecheng; Liu, Zhenglin
2015-10-16
Random number generators (RNG) play an important role in many sensor network systems and applications, such as those requiring secure and robust communications. In this paper, we develop a high-security and high-throughput hardware true random number generator, called PUFKEY, which consists of two kinds of physical unclonable function (PUF) elements. Combined with a conditioning algorithm, true random seeds are extracted from the noise on the start-up pattern of SRAM memories. These true random seeds contain full entropy. Then, the true random seeds are used as the input for a non-deterministic hardware RNG to generate a stream of true random bits with a throughput as high as 803 Mbps. The experimental results show that the bitstream generated by the proposed PUFKEY can pass all standard national institute of standards and technology (NIST) randomness tests and is resilient to a wide range of security attacks.
Dongfang Li
2015-10-01
Full Text Available Random number generators (RNG play an important role in many sensor network systems and applications, such as those requiring secure and robust communications. In this paper, we develop a high-security and high-throughput hardware true random number generator, called PUFKEY, which consists of two kinds of physical unclonable function (PUF elements. Combined with a conditioning algorithm, true random seeds are extracted from the noise on the start-up pattern of SRAM memories. These true random seeds contain full entropy. Then, the true random seeds are used as the input for a non-deterministic hardware RNG to generate a stream of true random bits with a throughput as high as 803 Mbps. The experimental results show that the bitstream generated by the proposed PUFKEY can pass all standard national institute of standards and technology (NIST randomness tests and is resilient to a wide range of security attacks.
A geometry-adaptive IB-LBM for FSI problems at moderate and high Reynolds numbers
Tian, Fangbao; Xu, Lincheng; Young, John; Lai, Joseph C. S.
2017-11-01
An FSI framework combining the LBM and an improved IBM is introduced for FSI problems at moderate and high Reynolds numbers. In this framework, the fluid dynamics is obtained by the LBM. The FSI boundary conditions are handled by an improved IBM based on the feedback scheme where the feedback coefficient is mathematically derived and explicitly approximated. The Lagrangian force is divided into two parts: one is caused by the mismatching of the flow velocity and the boundary velocity at previous time step, and the other is caused by the boundary acceleration. Such treatment significantly enhances the numerical stability. A geometry-adaptive refinement is applied to provide fine resolution around the immersed geometries. The overlapping grids between two adjacent refinements consist of two layers. The movement of fluid-structure interfaces only causes adding or removing grids at the boundaries of refinements. Finally, the classic Smagorinsky large eddy simulation model is incorporated into the framework to model turbulent flows at relatively high Reynolds numbers. Several validation cases are conducted to verify the accuracy and fidelity of the present solver over a range of Reynolds numbers. Mr L. Xu acknowledges the support of the University International Postgraduate Award by University of New South Wales. Dr. F.-B. Tian is the recipient of an Australian Research Council Discovery Early Career Researcher Award (Project Number DE160101098).
On the instabilities of supersonic mixing layers - A high-Mach-number asymptotic theory
Balsa, Thomas F.; Goldstein, M. E.
1990-01-01
The stability of a family of tanh mixing layers is studied at large Mach numbers using perturbation methods. It is found that the eigenfunction develops a multilayered structure, and the eigenvalue is obtained by solving a simplified version of the Rayleigh equation (with homogeneous boundary conditions) in one of these layers which lies in either of the external streams. This analysis leads to a simple hypersonic similarity law which explains how spatial and temporal phase speeds and growth rates scale with Mach number and temperature ratio. Comparisons are made with numerical results, and it is found that this similarity law provides a good qualitative guide for the behavior of the instability at high Mach numbers. In addition to this asymptotic theory, some fully numerical results are also presented (with no limitation on the Mach number) in order to explain the origin of the hypersonic modes (through mode splitting) and to discuss the role of oblique modes over a very wide range of Mach number and temperature ratio.
DNS of passive scalar transport in turbulent channel flow at high Schmidt numbers
Schwertfirm, Florian; Manhart, Michael
2007-01-01
We perform DNS of passive scalar transport in low Reynolds number turbulent channel flow at Schmidt numbers up to Sc = 49. The high resolutions required to resolve the scalar concentration fields at such Schmidt numbers are achieved by a hierarchical algorithm in which only the scalar fields are solved on the grid dictated by the Batchelor scale. The velocity fields are solved on coarser grids and prolonged by a conservative interpolation to the fine-grid. The trends observed so far at lower Schmidt numbers Sc ≤ 10 are confirmed, i.e. the mean scalar gradient steepens at the wall with increasing Schmidt number, the peaks of turbulent quantities increase and move towards the wall. The instantaneous scalar fields show a dramatic change. Observable structures get longer and thinner which is connected with the occurrence of steeper gradients, but the wall concentrations penetrate less deeply into the plateau in the core of the channel. Our data shows that the thickness of the conductive sublayer, as defined by the intersection point of the linear with the logarithmic asymptote scales with Sc -0.29 . With this information it is possible to derive an expression for the dimensionless transfer coefficient K + which is only dependent on Sc and Re τ . This expression is in full accordance to previous results which demonstrates that the thickness of the conductive sublayer is the dominating quantity for the mean scalar profile
DNS of passive scalar transport in turbulent channel flow at high Schmidt numbers
Schwertfirm, Florian [Fachgebiet Hydromechanik, Technische Universitaet Muenchen, Arcisstr. 21, 80337 Muenchen (Germany); Manhart, Michael [Fachgebiet Hydromechanik, Technische Universitaet Muenchen, Arcisstr. 21, 80337 Muenchen (Germany)], E-mail: m.manhart@bv.tum.de
2007-12-15
We perform DNS of passive scalar transport in low Reynolds number turbulent channel flow at Schmidt numbers up to Sc = 49. The high resolutions required to resolve the scalar concentration fields at such Schmidt numbers are achieved by a hierarchical algorithm in which only the scalar fields are solved on the grid dictated by the Batchelor scale. The velocity fields are solved on coarser grids and prolonged by a conservative interpolation to the fine-grid. The trends observed so far at lower Schmidt numbers Sc {<=} 10 are confirmed, i.e. the mean scalar gradient steepens at the wall with increasing Schmidt number, the peaks of turbulent quantities increase and move towards the wall. The instantaneous scalar fields show a dramatic change. Observable structures get longer and thinner which is connected with the occurrence of steeper gradients, but the wall concentrations penetrate less deeply into the plateau in the core of the channel. Our data shows that the thickness of the conductive sublayer, as defined by the intersection point of the linear with the logarithmic asymptote scales with Sc{sup -0.29}. With this information it is possible to derive an expression for the dimensionless transfer coefficient K{sup +} which is only dependent on Sc and Re{sub {tau}}. This expression is in full accordance to previous results which demonstrates that the thickness of the conductive sublayer is the dominating quantity for the mean scalar profile.
Jafari, Azadeh; Deville, Michel O.; Fiétier, Nicolas
2008-09-01
This study discusses the capability of the constitutive laws for the matrix logarithm of the conformation tensor (LCT model) within the framework of the spectral elements method. The high Weissenberg number problems (HWNP) usually produce a lack of convergence of the numerical algorithms. Even though the question whether the HWNP is a purely numerical problem or rather a breakdown of the constitutive law of the model has remained somewhat of a mystery, it has been recognized that the selection of an appropriate constitutive equation constitutes a very crucial step although implementing a suitable numerical technique is still important for successful discrete modeling of non-Newtonian flows. The LCT model formulation of the viscoelastic equations originally suggested by Fattal and Kupferman is applied for 2-dimensional (2D) FENE-CR model. The Planar Poiseuille flow is considered as a benchmark problem to test this representation at high Weissenberg number. The numerical results are compared with numerical solution of the standard constitutive equation.
Maximum compression of Z-pinch in a gas with high atomic number
Gerusov, A.V.
1989-01-01
An ideal system of equations with shock heating is used for describing of a Z pinch in a gas with high atomic number. In this case equations do not depend from the installation parameters. The approximate simple solution of such a system is presented. Numerical calculations of equations with radiative cooling and various dissipative effects have determined the employment conditions of ideal magnetohydrodynamic equation system. 10 refs
Surfing and drift acceleration at high mach number quasi-perpendicular shocks
Amano, T.
2008-01-01
Electron acceleration in high Mach number collisionless shocks relevant to supernova remnant is discussed. By performing one- and two-dimensional particle-in-cell simulations of quasi-perpendicular shocks, we find that energetic electrons are quickly generated in the shock transition region through shock surfing and drift acceleration. The electron energization is strong enough to account for the observed injection at supernova remnant shocks. (author)
Further experiments for mean velocity profile of pipe flow at high Reynolds number
Furuichi, N.; Terao, Y.; Wada, Y.; Tsuji, Y.
2018-05-01
This paper reports further experimental results obtained in high Reynolds number actual flow facility in Japan. The experiments were performed in a pipe flow with water, and the friction Reynolds number was varied up to Reτ = 5.3 × 104. This high Reynolds number was achieved by using water as the working fluid and adopting a large-diameter pipe (387 mm) while controlling the flow rate and temperature with high accuracy and precision. The streamwise velocity was measured by laser Doppler velocimetry close to the wall, and the mean velocity profile, called log-law profile U+ = (1/κ) ln(y+) + B, is especially focused. After careful verification of the mean velocity profiles in terms of the flow rate accuracy and an evaluation of the consistency of the present results with those from previously measurements in a smaller pipe (100 mm), it was found that the value of κ asymptotically approaches a constant value of κ = 0.384.
Gourdon, Mathias; Karlsson, Erik; Innings, Fredrik; Jongsma, Alfred; Vamling, Lennart
2016-02-01
In many industrial applications, falling film evaporation is an attractive technique for solvent removal due to high heat transfer and low residence times. Examples are the powder production in the dairy industry and in kraft pulp production process to remove water from so called black liquor. Common for both applications is that the fluids exhibit high viscosities in industrial practice. In this paper, results from experimental studies on both black liquor and a dairy product are reported for Prandtl numbers up to 800. The results are compared with several existing correlation in literature, and the need for a modified correlation is recognized especially to cover higher Prandtl-numbers. The following correlation for the turbulent flow region with 3 < Pr < 800 was derived from the data: {Nu}t = 0.0085 \\cdot Re^{0.2} \\cdot {Pr^{0.65}} The correlation has been compared to literature data from one additional study on two other fluids (propylene glycol and cyclohexanol) with fairly high Prandtl-numbers, from 40 to 58 and from 45 to 155 respectively and the agreement was within ±40 %.
High-Energy String Scattering Amplitudes and Signless Stirling Number Identity
Jen-Chi Lee
2012-07-01
Full Text Available We give a complete proof of a set of identities (7 proposed recently from calculation of high-energy string scattering amplitudes. These identities allow one to extract ratios among high-energy string scattering amplitudes in the fixed angle regime from high-energy amplitudes in the Regge regime. The proof is based on a signless Stirling number identity in combinatorial theory. The results are valid for arbitrary real values L rather than only for L=0,1 proved previously. The identities for non-integer real value L were recently shown to be realized in high-energy compactified string scattering amplitudes [He S., Lee J.C., Yang Y., arXiv:1012.3158]. The parameter L is related to the mass level of an excited string state and can take non-integer values for Kaluza-Klein modes.
High-Reynolds Number Circulation Control Testing in the National Transonic Facility
Milholen, William E., II; Jones, Gregory S.; Chan, David T.; Goodliff, Scott L.
2012-01-01
A new capability to test active flow control concepts and propulsion simulations at high Reynolds numbers in the National Transonic Facility at the NASA Langley Research Center is being developed. The first active flow control experiment was completed using the new FAST-MAC semi-span model to study Reynolds number scaling effects for several circulation control concepts. Testing was conducted over a wide range of Mach numbers, up to chord Reynolds numbers of 30 million. The model was equipped with four onboard flow control valves allowing independent control of the circulation control plenums, which were directed over a 15% chord simple-hinged flap. Preliminary analysis of the uncorrected lift data showed that the circulation control increased the low-speed maximum lift coefficient by 33%. At transonic speeds, the circulation control was capable of positively altering the shockwave pattern on the upper wing surface and reducing flow separation. Furthermore, application of the technique to only the outboard portion of the wing demonstrated the feasibility of a pneumatic based roll control capability.
Study of Perturbations on High Mach Number Blast Waves in Various Gasses
Edens, A.; Adams, R.; Rambo, P.; Shores, J.; Smith, I.; Atherton, B.; Ditmire, T.
2006-10-01
We have performed a series of experiments examining the properties of high Mach number blast waves. Experiments were conducted on the Z-Beamlet^1 laser at Sandia National Laboratories. We created blast waves in the laboratory by using 10 J- 1000 J laser pulses to illuminate millimeter scale solid targets immersed in gas. Our experiments studied the validity of theories forwarded by Vishniac and Ryu^2-4 to explain the dynamics of perturbations on astrophysical blast waves. These experiments consisted of an examination of the evolution of perturbations of known primary mode number induced on the surface of blast waves by means of regularly spaced wire arrays. The temporal evolution of the amplitude of the induced perturbations relative to the mean radius of the blast wave was fit to a power law in time. Measurements were taken for a number of different mode numbers and background gasses and the results show qualitative agreement with previously published theories for the hydrodynamics of thin shell blast wave. The results for perturbations on nitrogen gas have been recently published^5. .^1 P. K. Rambo, I. C. Smith, J. L. Porter, et al., Applied Optics 44, 2421 (2005). ^2 D. Ryu and E. T. Vishniac, Astrophysical Journal 313, 820 (1987). ^3 D. Ryu and E. T. Vishniac, Astrophysical Journal 368, 411 (1991). ^4 E. T. Vishniac, Astrophysical Journal 274, 152 (1983). ^5 A. D. Edens, T. Ditmire, J. F. Hansen, et al., Physical Review Letters 95 (2005).
Thermodynamic analysis on optimum performance of scramjet engine at high Mach numbers
Zhang, Duo; Yang, Shengbo; Zhang, Silong; Qin, Jiang; Bao, Wen
2015-01-01
In order to predict the maximum performance of scramjet engine at flight conditions with high freestream Mach numbers, a thermodynamic model of Brayton cycle was utilized to analyze the effects of inlet pressure ratio, fuel equivalence ratio and the upper limit of gas temperature to the specific thrust and the fuel impulse of the scramjet considering the characteristics of non-isentropic compression in the inlet. The results show that both the inlet efficiency and the temperature limit in the combustor have remarkable effects on the overall engine performances. Different with the ideal Brayton cycles assuming isentropic compression without upper limit of gas temperature, both the maximum specific thrust and the maximum fuel impulse of a scramjet present non-monotonic trends against the fuel equivalence ratio in this study. Considering the empirical design efficiencies of inlet, there is a wide range of fuel equivalence ratios in which the fuel impulses remain at high values. Moreover, the maximum specific thrust can also be achieved with a fuel equivalence ratio near this range. Therefore, it is possible to achieve an overall high performance in a scramjet at high Mach numbers. - Highlights: • Thermodynamic analysis with Brayton cycle on overall performances of scramjet. • The compression loss in the inlet was considered in predicting scram-mode operation. • Non-monotonic trends of engine performances against fuel equivalence ratio.
The time scale for the transition to turbulence in a high Reynolds number, accelerated flow
Robey, H.F.; Zhou Ye; Buckingham, A.C.; Keiter, P.; Remington, B.A.; Drake, R.P.
2003-01-01
An experiment is described in which an interface between materials of different density is subjected to an acceleration history consisting of a strong shock followed by a period of deceleration. The resulting flow at this interface, initiated by the deposition of strong laser radiation into the initially well characterized solid materials, is unstable to both the Richtmyer-Meshkov (RM) and Rayleigh-Taylor (RT) instabilities. These experiments are of importance in their ability to access a difficult experimental regime characterized by very high energy density (high temperature and pressure) as well as large Reynolds number and Mach number. Such conditions are of interest, for example, in the study of the RM/RT induced mixing that occurs during the explosion of a core-collapse supernova. Under these experimental conditions, the flow is in the plasma state and given enough time will transition to turbulence. By analysis of the experimental data and a corresponding one-dimensional numerical simulation of the experiment, it is shown that the Reynolds number is sufficiently large (Re>10 5 ) to support a turbulent flow. An estimate of three key turbulence length scales (the Taylor and Kolmogorov microscales and a viscous diffusion scale), however, shows that the temporal duration of the present flow is insufficient to allow for the development of a turbulent inertial subrange. A methodology is described for estimating the time required under these conditions for the development of a fully turbulent flow
Gotoh, Toshiyuki
2012-11-01
Spectrum of passive scalar variance at very high Schmidt number up to 1000 in isotropic steady turbulence has been studied by using very high resolution DNS. Gaussian random force and scalar source which are isotropic and white in time are applied at low wavenumber band. Since the Schmidt number is very large, the system was integrated for 72 large eddy turn over time for the system to forgot the initial state. It is found that the scalar spectrum attains the asymptotic k-1 spectrum in the viscous-convective range and the constant CB is found to be 5.7 which is larger than 4.9 obtained by DNS under the uniform mean scalar gradient. Reasons for the difference are inferred as the Reynolds number effect, anisotropy, difference in the scalar injection, duration of time average, and the universality of the constant is discussed. The constant CB is also compared with the prediction by the Lagrangian statistical theory for the passive scalar. The scalar spectrum in the far diffusive range is found to be exponential, which is consistent with the Kraichnan's spectrum. However, the Kraichnan spectrum was derived under the assumption that the velocity field is white in time, therefore theoretical explanation of the agreement needs to be explored. Grant-in-Aid for Scientific Research No. 21360082, Ministry of Education, Culture, Sports, Science and Technology of Japan.
Dynamic Impacts of Water Droplets onto Icephobic Soft Surfaces at High Weber Numbers
Ma, Liqun; Liu, Yang; Hu, Hui; Wang, Wei; Kota, Arun
2017-11-01
An experimental investigation was performed to examine the effects of the stiffness of icephobic soft PDMS materials on the impact dynamics of water drops at high weber numbers pertinent to aircraft icing phenomena. The experimental study was performed in the Icing Research Tunnel available at Iowa State University (ISU-IRT). During the experiments, both the shear modulus of the soft PDMS surface and the Weber numbers of the impinging water droplets are controlled for the comparative study. While the shear modulus of the soft PDMS surface was changed by tuning the recipes to make the PDMS materials, the Weber number of the impinging water droplets was altered by adjusting the airflow speed in the wind tunnel. A suite of advanced flow diagnostic techniques, which include high-speed photographic imaging, digital image projection (DIP), and infrared (IR) imaging thermometry, were used to quantify the transient behavior of water droplet impingement, unsteady heat transfer and dynamic ice accreting process over the icephobic soft airfoil surfaces. The findings derived from the icing physics studies can be used to improve current icing accretion models for more accurate prediction of ice formation and accretion on aircraft wings and to develop effective anti-/deicing strategies for safer and more efficient operation of aircraft in cold weather.
Modification of diode characteristics by electron back-scatter from high-atomic-number anodes
Mosher, D.; Cooperstein, G.; Rose, D.V.; Swanekamp, S.B.
1996-01-01
In high-power vacuum diodes with high-atomic-number anodes, back-scattered electrons alter the vacuum space charge and resulting electron and ion currents. Electron multiple back-scattering was studied through equilibrium solutions of the Poisson equation for 1-dimensional, bipolar diodes in order to predict their early-time behavior. Before ion turn-on, back-scattered electrons from high-Z anodes suppress the diode current by about 10%. After ion turn-on in the same diodes, electron back-scatter leads to substantial enhancements of both the electron and ion currents above the Child-Langmuir values. Current enhancements with ion flow from low-Z anodes are small. (author). 5 figs., 7 refs
Sensitivity of boundary-layer stability to base-state distortions at high Mach numbers
Park, Junho; Zaki, Tamer
2017-11-01
The stability diagram of high-speed boundary layers has been established by evaluating the linear instability modes of the similarity profile, over wide ranges of Reynolds and Mach numbers. In real flows, however, the base state can deviate from the similarity profile. Both the base velocity and temperature can be distorted, for example due to roughness and thermal wall treatments. We review the stability problem of high-speed boundary layer, and derive a new formulation of the sensitivity to base-state distortion using forward and adjoint parabolized stability equations. The new formulation provides qualitative and quantitative interpretations on change in growth rate due to modifications of mean-flow and mean-temperature in heated high-speed boundary layers, and establishes the foundation for future control strategies. This work has been funded by the Air Force Office of Scientific Research (AFOSR) Grant: FA9550-16-1-0103.
System for high-voltage control detectors with large number photomultipliers
Donskov, S.V.; Kachanov, V.A.; Mikhajlov, Yu.V.
1985-01-01
A simple and inexpensive on-line system for hihg-voltage control which is designed for detectors with a large number of photomultipliers is developed and manufactured. It has been developed for the GAMC type hodoscopic electromagnetic calorimeters, comprising up to 4 thousand photomultipliers. High voltage variation is performed by a high-speed potentiometer which is rotated by a microengine. Block-diagrams of computer control electronics are presented. The high-voltage control system has been used for five years in the IHEP and CERN accelerator experiments. The operation experience has shown that it is quite simple and convenient in operation. In case of about 6 thousand controlled channels in both experiments no potentiometer and microengines failures were observed
Modification of diode characteristics by electron back-scatter from high-atomic-number anodes
Mosher, D; Cooperstein, G [Naval Research Laboratory, Washington, DC (United States); Rose, D V; Swanekamp, S B [JAYCOR, Vienna, VA (United States)
1997-12-31
In high-power vacuum diodes with high-atomic-number anodes, back-scattered electrons alter the vacuum space charge and resulting electron and ion currents. Electron multiple back-scattering was studied through equilibrium solutions of the Poisson equation for 1-dimensional, bipolar diodes in order to predict their early-time behavior. Before ion turn-on, back-scattered electrons from high-Z anodes suppress the diode current by about 10%. After ion turn-on in the same diodes, electron back-scatter leads to substantial enhancements of both the electron and ion currents above the Child-Langmuir values. Current enhancements with ion flow from low-Z anodes are small. (author). 5 figs., 7 refs.
Hierarchy of kissing numbers for exceptional Lie symmetry groups in high energy physics
El Naschie, M.S.
2008-01-01
We are constructing a hierarchy of kissing numbers representing singular contact points of hyper-spheres in exceptional Lie symmetry groups lattice arrangement embedded in the 26 dimensional bosonic strings spacetime. That way we find a total number of points and dimensions equal to 548. This is 52 more than the order of E 8 E 8 of heterotic string theory and leads to the prediction of 69 elementary particles at an energy scale under 1 T. In other words, our mathematical model predicts nine more particles than what is currently experimentally known to exist in the standard model of high energy physics namely only 60. The result is thus in full agreement with all our previous theoretical findings
Orujova, J.R.; Dzhafarov, E.S.
2006-01-01
Full text: The activity circle of man includes also change of the radio ecological situation of environment, global increase of natural radiation phone, appearance of the local territories polluted with radio nuclides in result of technological processes, chemical pollution of air, water, land etc. As it's known, reaction of different plants to the impact of both natural, and anthropogenic stress factors isn't identical. This time change of the biometrical measures of plants' different organs, growth of their reproduction features, acceleration of biologically active matters synthesis etc. facts we elucidated in many works. The research works show that under external influence biological parameters don't change identically. Taking into account different character of the dependence of biochemical processes in plants on the external effects, and scarceness of research works on territories polluted by radio active industrial waste products, we can say that, respective experiments are needed. In the present work territory of iodine plant in Rome polluted with radio nuclides has been regarded as the experimental one. Within the plant area there was registered radiation phone totaling 800-1000 mkR/h. Ra 226, Th 232, U 238 and K 40 were detected as radio nucleids polluting the area. The work has spectrometrically identified number of the photosynthetic pigments of Alhagi Pseudalhagi plant formed both in conditions of high radiation phone, and in the control area in wild conditions. In result of measures there were calculated individual number of chlorophyllum a and b pigments playing photoreceptor role in photosynthesis process and having big importance for superior plants, ratio of chlorophyllum a to chlorophyllum b and the total. Besides, there has been designated number of carotinoids executing defensive function in chloroplasts. Results received show that in comparison with control in autumn season total number of green pigments is approximately two times lower than
Rader, D.J.; Benson, D.A.
1995-05-01
This report presents the results of an experimental study of the aerosol produced by the combustion of high-velocity molten-uranium droplets produced by the simultaneous heating and electromagnetic launch of uranium wires. These tests are intended to simulate the reduction of high-velocity fragments into aerosol in high-explosive detonations or reactor accidents involving nuclear materials. As reported earlier, the resulting aerosol consists mainly of web-like chain agglomerates. A condensation nucleus counter was used to investigate the decay of the total particle concentration due to coagulation and losses. Number size distributions based on mobility equivalent diameter obtained soon after launch with a Differential Mobility Particle Sizer showed lognormal distributions with an initial count median diameter (CMD) of 0.3 {mu}m and a geometric standard deviation, {sigma}{sub g} of about 2; the CMD was found to increase and {sigma}{sub g} decrease with time due to coagulation. Mass size distributions based on aerodynamic diameter were obtained for the first time with a Microorifice Uniform Deposit Impactor, which showed lognormal distributions with mass median aerodynamic diameters of about 0.5 {mu}m and an aerodynamic geometric standard deviation of about 2. Approximate methods for converting between number and mass distributions and between mobility and aerodynamic equivalent diameters are presented.
Rader, D.J.; Benson, D.A.
1995-05-01
This report presents the results of an experimental study of the aerosol produced by the combustion of high-velocity molten-uranium droplets produced by the simultaneous heating and electromagnetic launch of uranium wires. These tests are intended to simulate the reduction of high-velocity fragments into aerosol in high-explosive detonations or reactor accidents involving nuclear materials. As reported earlier, the resulting aerosol consists mainly of web-like chain agglomerates. A condensation nucleus counter was used to investigate the decay of the total particle concentration due to coagulation and losses. Number size distributions based on mobility equivalent diameter obtained soon after launch with a Differential Mobility Particle Sizer showed lognormal distributions with an initial count median diameter (CMD) of 0.3 μm and a geometric standard deviation, σ g of about 2; the CMD was found to increase and σ g decrease with time due to coagulation. Mass size distributions based on aerodynamic diameter were obtained for the first time with a Microorifice Uniform Deposit Impactor, which showed lognormal distributions with mass median aerodynamic diameters of about 0.5 μm and an aerodynamic geometric standard deviation of about 2. Approximate methods for converting between number and mass distributions and between mobility and aerodynamic equivalent diameters are presented
Reyt, Ida; Bailliet, Hélène; Valière, Jean-Christophe
2014-01-01
Measurements of streaming velocity are performed by means of Laser Doppler Velocimetry and Particle Image Velociimetry in an experimental apparatus consisting of a cylindrical waveguide having one loudspeaker at each end for high intensity sound levels. The case of high nonlinear Reynolds number ReNL is particularly investigated. The variation of axial streaming velocity with respect to the axial and to the transverse coordinates are compared to available Rayleigh streaming theory. As expected, the measured streaming velocity agrees well with the Rayleigh streaming theory for small ReNL but deviates significantly from such predictions for high ReNL. When the nonlinear Reynolds number is increased, the outer centerline axial streaming velocity gets distorted towards the acoustic velocity nodes until counter-rotating additional vortices are generated near the acoustic velocity antinodes. This kind of behavior is followed by outer streaming cells only and measurements in the near wall region show that inner streaming vortices are less affected by this substantial evolution of fast streaming pattern. Measurements of the transient evolution of streaming velocity provide an additional insight into the evolution of fast streaming.
Nielsen, Anne E. B.; Muschik, Christine A.; Giedke, Geza
2010-01-01
We propose and analyze a multifunctional setup consisting of high-finesse optical cavities, beam splitters, and phase shifters. The basic scheme projects arbitrary photonic two-mode input states onto the subspace spanned by the product of Fock states |n>|n> with n=0,1,2,.... This protocol does no...... is especially attractive as a generalization to many modes allows for distribution and purification of entanglement in networks. In an alternative working mode, the setup allows for quantum nondemolition number resolved photodetection in the optical domain....
Anomalous dissipation and kinetic-energy distribution in pipes at very high Reynolds numbers.
Chen, Xi; Wei, Bo-Bo; Hussain, Fazle; She, Zhen-Su
2016-01-01
A symmetry-based theory is developed for the description of (streamwise) kinetic energy K in turbulent pipes at extremely high Reynolds numbers (Re's). The theory assumes a mesolayer with continual deformation of wall-attached eddies which introduce an anomalous dissipation, breaking the exact balance between production and dissipation. An outer peak of K is predicted above a critical Re of 10^{4}, in good agreement with experimental data. The theory offers an alternative explanation for the recently discovered logarithmic distribution of K. The concept of anomalous dissipation is further supported by a significant modification of the k-ω equation, yielding an accurate prediction of the entire K profile.
Effects of external environment on thermocapillary convection of high prandtl number fluid
Liang Ruquan
2016-01-01
Full Text Available Numerical simulations have been carried out to investigate the influence of external environment on thermocapillary convection in high Prandtl number (Pr=68 liquid. The geometric model of physical problem is that the the liquid bridge surrounded by ambient air under zero or ground gravity. The interface velocity, temperature, heat flux and flow pattern in the liquid bridge are presented and discussed under different conditions by changing the external environment. The buoyancy convection produces a symmetrical vortex in the liquid bridge. The ambient air affects the distributions of the temperature velocity and heat flux on the interface by changing the thermocapillary convection.
Kim, J.-H.; Nishihara, M.; Adamovich, I.V.; Samimy, M.; Gorbatov, S.V.; Pliavaka, F.V.
2010-01-01
Recently developed localized arc filament plasma actuators (LAFPAs) have shown tremendous control authority in high-speed and high Reynolds number flow for mixing enhancement and noise mitigation. Previously, these actuators were powered by a high-voltage pulsed DC plasma generator with low energy coupling efficiency of 5-10%. In the present work, a new custom-designed 8-channel pulsed radio frequency (RF) plasma generator has been developed to power up to 8 plasma actuators operated over a wide range of forcing frequencies (up to 50 kHz) and duty cycles (1-50%), and at high energy coupling efficiency (up to 80-85%). This reduces input electrical power requirements by approximately an order of magnitude, down to 12 W per actuator operating at 10% duty cycle. The new pulsed RF plasma generator is scalable to a system with a large number of channels. Performance of pulsed RF plasma actuators used for flow control was studied in a Mach 0.9 circular jet with a Reynolds number of about 623,000 and compared with that of pulsed DC actuators. Eight actuators were distributed uniformly on the perimeter of a 2.54-cm diameter circular nozzle extension. Both types of actuators coupled approximately the same amount of power to the flow, but with drastically different electrical inputs to the power supplies. Particle image velocimetry measurements showed that jet centerline Mach number decay produced by DC and RF actuators operating at the same forcing frequencies and duty cycles is very similar. At a forcing Strouhal number near 0.3, close to the jet column instability frequency, well-organized periodic structures, with similar patterns and dimensions, were generated in the jets forced by both DC and RF actuators. Far-field acoustic measurements demonstrated similar trends in the overall sound pressure level (OASPL) change produced by both types of actuators, resulting in OASPL reduction up to 1.2-1.5 dB in both cases. We conclude that pulsed RF actuators demonstrate flow
DNS/LES Simulations of Separated Flows at High Reynolds Numbers
Balakumar, P.
2015-01-01
Direct numerical simulations (DNS) and large-eddy simulations (LES) simulations of flow through a periodic channel with a constriction are performed using the dynamic Smagorinsky model at two Reynolds numbers of 2800 and 10595. The LES equations are solved using higher order compact schemes. DNS are performed for the lower Reynolds number case using a fine grid and the data are used to validate the LES results obtained with a coarse and a medium size grid. LES simulations are also performed for the higher Reynolds number case using a coarse and a medium size grid. The results are compared with an existing reference data set. The DNS and LES results agreed well with the reference data. Reynolds stresses, sub-grid eddy viscosity, and the budgets for the turbulent kinetic energy are also presented. It is found that the turbulent fluctuations in the normal and spanwise directions have the same magnitude. The turbulent kinetic energy budget shows that the production peaks near the separation point region and the production to dissipation ratio is very high on the order of five in this region. It is also observed that the production is balanced by the advection, diffusion, and dissipation in the shear layer region. The dominant term is the turbulent diffusion that is about two times the molecular dissipation.
Trajectory of a synthetic jet issuing into a high Reynolds number turbulent boundary layer
Berk, Tim; Baidya, Rio; de Silva, Charitha; Marusic, Ivan; Hutchins, Nicholas; Ganapathisubramani, Bharathram
2017-11-01
Synthetic jets are zero-net-mass-flux actuators that can be used in a range of flow control applications. For several pulsed/synthetic jet in cross-flow applications the variation of the jet trajectory in the mean flow with jet and boundary layer parameters is important. This trajectory will provide an indication of the penetration depth of the pulsed/synthetic jet into a boundary layer. Trajectories of a synthetic jet in a turbulent boundary layer are measured for a range of actuation parameters in both low- and high Reynolds numbers (up to Reτ = 13000). The important parameters influencing the trajectory are determined from these measurements. The Reynolds number of the boundary layer is shown to only have a small effect on the trajectory. In fact, the critical parameters are found to be the Strouhal number of the jet based on jet dimensions as well as the velocity ratio of the jet (defined as a ratio between peak jet velocity and the freestream velocity). An expression for the trajectory of the synthetic (or pulsed) jet is derived from the data, which (in the limit) is consistent with known expressions for the trajectory of a steady jet in a cross-flow. T.B. and B.G. are grateful to the support from the ERC (Grant Agreement No. 277472) and the EPSRC (Grant ref. no. EP/L006383/1).
Efficient high speed communications over electrical powerlines for a large number of users
Lee, J.; Tripathi, K.; Latchman, H.A. [Florida Univ., Gainesville, FL (United States). Dept. of Electrical and Computer Engineering
2007-07-01
Affordable broadband Internet communication is currently available for residential use via cable modem and other forms of digital subscriber lines (DSL). Powerline communication (PLC) systems were never considered seriously for communications due to their low speed and high development cost. However, due to technological advances PLCs are now spreading to local area networks and broadband over power line systems. This paper presented a newly proposed modification to the standard HomePlug 1.0 MAC protocol to make it a constant contention window-based scheme. The HomePlug 1.0 was developed based on orthogonal frequency division multiplexing (OFDM) and carrier sense multiple access with collision avoidance (CSMA/CA). It is currently the most commonly used technology of power line communications, supporting a transmission rate of up to 14 Mbps on the power line. However, the throughput performance of this original scheme becomes critical when the number of users increases. For that reason, a constant contention window based medium access control protocol algorithm of HomePlug 1.0 was proposed under the assumption that the number of active stations is known. An analytical framework based on Markov Chains was developed in order to model this modified protocol under saturation conditions. Modeling results accurately matched the actual performance of the system. This paper revealed that the performance can be improved significantly if the variables were parameterized in terms of the number of active stations. 15 refs., 1 tab., 6 figs.
Whole genome DNA copy number changes identified by high density oligonucleotide arrays
Huang Jing
2004-05-01
Full Text Available Abstract Changes in DNA copy number are one of the hallmarks of the genetic instability common to most human cancers. Previous micro-array-based methods have been used to identify chromosomal gains and losses; however, they are unable to genotype alleles at the level of single nucleotide polymorphisms (SNPs. Here we describe a novel algorithm that uses a recently developed high-density oligonucleotide array-based SNP genotyping method, whole genome sampling analysis (WGSA, to identify genome-wide chromosomal gains and losses at high resolution. WGSA simultaneously genotypes over 10,000 SNPs by allele-specific hybridisation to perfect match (PM and mismatch (MM probes synthesised on a single array. The copy number algorithm jointly uses PM intensity and discrimination ratios between paired PM and MM intensity values to identify and estimate genetic copy number changes. Values from an experimental sample are compared with SNP-specific distributions derived from a reference set containing over 100 normal individuals to gain statistical power. Genomic regions with statistically significant copy number changes can be identified using both single point analysis and contiguous point analysis of SNP intensities. We identified multiple regions of amplification and deletion using a panel of human breast cancer cell lines. We verified these results using an independent method based on quantitative polymerase chain reaction and found that our approach is both sensitive and specific and can tolerate samples which contain a mixture of both tumour and normal DNA. In addition, by using known allele frequencies from the reference set, statistically significant genomic intervals can be identified containing contiguous stretches of homozygous markers, potentially allowing the detection of regions undergoing loss of heterozygosity (LOH without the need for a matched normal control sample. The coupling of LOH analysis, via SNP genotyping, with copy number
High-fidelity simulations of moving and flexible airfoils at low Reynolds numbers
Visbal, Miguel R.; Gordnier, Raymond E.; Galbraith, Marshall C. [Air Force Research Laboratory, Computational Sciences Branch, Air Vehicles Directorate, Wright-Patterson AFB, OH (United States)
2009-05-15
The present paper highlights results derived from the application of a high-fidelity simulation technique to the analysis of low-Reynolds-number transitional flows over moving and flexible canonical configurations motivated by small natural and man-made flyers. This effort addresses three separate fluid dynamic phenomena relevant to small fliers, including: laminar separation and transition over a stationary airfoil, transition effects on the dynamic stall vortex generated by a plunging airfoil, and the effect of flexibility on the flow structure above a membrane airfoil. The specific cases were also selected to permit comparison with available experimental measurements. First, the process of transition on a stationary SD7003 airfoil section over a range of Reynolds numbers and angles of attack is considered. Prior to stall, the flow exhibits a separated shear layer which rolls up into spanwise vortices. These vortices subsequently undergo spanwise instabilities, and ultimately breakdown into fine-scale turbulent structures as the boundary layer reattaches to the airfoil surface. In a time-averaged sense, the flow displays a closed laminar separation bubble which moves upstream and contracts in size with increasing angle of attack for a fixed Reynolds number. For a fixed angle of attack, as the Reynolds number decreases, the laminar separation bubble grows in vertical extent producing a significant increase in drag. For the lowest Reynolds number considered (Re{sub c} = 10 {sup 4}), transition does not occur over the airfoil at moderate angles of attack prior to stall. Next, the impact of a prescribed high-frequency small-amplitude plunging motion on the transitional flow over the SD7003 airfoil is investigated. The motion-induced high angle of attack results in unsteady separation in the leading edge and in the formation of dynamic-stall-like vortices which convect downstream close to the airfoil. At the lowest value of Reynolds number (Re{sub c}=10 {sup 4
The effect of high frequency sound on Culicoides numbers collected with suction light traps
Gert J. Venter
2012-04-01
Full Text Available Culicoides midges (Diptera: Ceratopogonidae, are involved in the transmission of various pathogens that cause important diseases of livestock worldwide. The use of insect repellents to reduce the attack rate of these insects on livestock could play an important role as part of an integrated control programme against diseases transmitted by these midges. The objective of this study was to determine whether high frequency sound has any repellent effect on Culicoides midges. The number of midges collected with 220 V Onderstepoort white light traps fitted with electronic mosquito repellents (EMRs, emitting 5-20 KHz multi-frequency sound waves, was compared with that of two untreated traps. Treatments were rotated in two replicates of a 4 x 4 randomised Latin square design. Although fewer midges were collected in the two traps fitted with EMRs, the average number collected over eight consecutive nights was not significantly different. The EMRs also had no influence on any of the physiological groups of Culicoides imicola Kieffer or the species composition of the Culicoides population as determined with light traps. The results indicate that high frequency sound has no repellent effect on Culicoides midges. There is therefore no evidence to support their promotion or use in the protection of animals against pathogens transmitted by Culicoides midges.
Patil, Sunil; Tafti, Danesh
2012-01-01
Highlights: ► Large eddy simulation. ► Wall layer modeling. ► Synthetic inlet turbulence. ► Swirl flows. - Abstract: Large eddy simulations of complex high Reynolds number flows are carried out with the near wall region being modeled with a zonal two layer model. A novel formulation for solving the turbulent boundary layer equation for the effective tangential velocity in a generalized co-ordinate system is presented and applied in the near wall zonal treatment. This formulation reduces the computational time in the inner layer significantly compared to the conventional two layer formulations present in the literature and is most suitable for complex geometries involving body fitted structured and unstructured meshes. The cost effectiveness and accuracy of the proposed wall model, used with the synthetic eddy method (SEM) to generate inlet turbulence, is investigated in turbulent channel flow, flow over a backward facing step, and confined swirling flows at moderately high Reynolds numbers. Predictions are compared with available DNS, experimental LDV data, as well as wall resolved LES. In all cases, there is at least an order of magnitude reduction in computational cost with no significant loss in prediction accuracy.
Multi-resolution Delta-plus-SPH with tensile instability control: Towards high Reynolds number flows
Sun, P. N.; Colagrossi, A.; Marrone, S.; Antuono, M.; Zhang, A. M.
2018-03-01
It is well known that the use of SPH models in simulating flow at high Reynolds numbers is limited because of the tensile instability inception in the fluid region characterized by high vorticity and negative pressure. In order to overcome this issue, the δ+-SPH scheme is modified by implementing a Tensile Instability Control (TIC). The latter consists of switching the momentum equation to a non-conservative formulation in the unstable flow regions. The loss of conservation properties is shown to induce small errors, provided that the particle distribution is regular. The latter condition can be ensured thanks to the implementation of a Particle Shifting Technique (PST). The novel variant of the δ+-SPH is proved to be effective in preventing the onset of tensile instability. Several challenging benchmark tests involving flows past bodies at large Reynolds numbers have been used. Within this a simulation characterized by a deforming foil that resembles a fish-like swimming body is used as a practical application of the δ+-SPH model in biological fluid mechanics.
The break-up of a viscous liquid drop in a high Reynolds number shear flow
Ng, Chin Hei; Aliseda, Alberto
2015-11-01
The break-up of a viscous liquid droplet in a sheared turbulent flow evolves in several steps, the most visually dominant of which is the formation of high aspect ratio ligaments. This feature takes them apart from the various break-up models based on the Hinze-Kolmogorov paradigm of eddy-spherical particle collisions. We investigate the development of ligaments in a high Reynolds number (up to 250,000) submerged round jet, within the high viscosity, near-unity density ratio regime. Unlike in H-K theory, applicable to the break-up of inviscid fluid particles, break-up of inertial-scale viscous droplets occurs through a sequence of eddy collisions and long-term deformation, as evidenced by measurements of the aspect ratio that fluctuates and increases progressively during the deformation stage, and results in non-binary break-up. Additionally, the ligament formation stretches a droplet to multiple times its original size, bringing the influence of integral-scale structures. High speed imaging has been statistically analyzed to inform and validate theoretical models for the break-up time and the break-up probability. In addition, a particle size scaling model has been developed and compared with the experimental measurements of the frozen-state particle size.
High-resolution copy number variation analysis of schizophrenia in Japan.
Kushima, I; Aleksic, B; Nakatochi, M; Shimamura, T; Shiino, T; Yoshimi, A; Kimura, H; Takasaki, Y; Wang, C; Xing, J; Ishizuka, K; Oya-Ito, T; Nakamura, Y; Arioka, Y; Maeda, T; Yamamoto, M; Yoshida, M; Noma, H; Hamada, S; Morikawa, M; Uno, Y; Okada, T; Iidaka, T; Iritani, S; Yamamoto, T; Miyashita, M; Kobori, A; Arai, M; Itokawa, M; Cheng, M-C; Chuang, Y-A; Chen, C-H; Suzuki, M; Takahashi, T; Hashimoto, R; Yamamori, H; Yasuda, Y; Watanabe, Y; Nunokawa, A; Someya, T; Ikeda, M; Toyota, T; Yoshikawa, T; Numata, S; Ohmori, T; Kunimoto, S; Mori, D; Iwata, N; Ozaki, N
2017-03-01
Recent schizophrenia (SCZ) studies have reported an increased burden of de novo copy number variants (CNVs) and identified specific high-risk CNVs, although with variable phenotype expressivity. However, the pathogenesis of SCZ has not been fully elucidated. Using array comparative genomic hybridization, we performed a high-resolution genome-wide CNV analysis on a mainly (92%) Japanese population (1699 SCZ cases and 824 controls) and identified 7066 rare CNVs, 70.0% of which were small (history of congenital/developmental phenotypes, and the rate of treatment resistance was significantly higher (odds ratio=2.79, P=0.0036). We found more severe clinical manifestations in patients with two clinically significant CNVs. Gene set analysis replicated previous findings (e.g., synapse, calcium signaling) and identified novel biological pathways including oxidative stress response, genomic integrity, kinase and small GTPase signaling. Furthermore, involvement of multiple SCZ candidate genes and biological pathways in the pathogenesis of SCZ was suggested in established SCZ-associated CNV loci. Our study shows the high genetic heterogeneity of SCZ and its clinical features and raises the possibility that genomic instability is involved in its pathogenesis, which may be related to the increased burden of de novo CNVs and variable expressivity of CNVs.
Optimal Pole Number and Winding Designs for Low Speed–High Torque Synchronous Reluctance Machines
Gurutz Artetxe
2018-01-01
Full Text Available This paper studies the feasibility of using synchronous reluctance machines (SynRM for low speed–high torque applications. The challenge lies in obtaining low torque ripple values, high power factor, and, especially, high torque density values, comparable to those of permanent magnet synchronous machines (PMSMs, but without resorting to use permanent magnets. A design and calculation procedure based on multistatic finite element analysis is developed and experimentally validated via a 200 Nm, 160 rpm prototype SynRM. After that, machine designs with different rotor pole and stator slot number combinations are studied, together with different winding types: integral-slot distributed-windings (ISDW, fractional-slot distributed-windings (FSDW and fractional-slot concentrated-windings (FSCW. Some design criteria for low-speed SynRM are drawn from the results of the study. Finally, a performance comparison between a PMSM and a SynRM is performed for the same application and the conclusions of the study are summarized.
Renksizbulut, M.
Nusselt Numbers and drag coefficients of single-component liquid droplets and solid spheres in high temperature, intermediate Reynolds Number flows were investigated. The evaporation of suspended water, Methanol and n-Heptane droplets were followed in laminar air streams up to 1059 K in temperature using a steady-state measurement technique. It is found that the dynamic blowing effect of evaporation causes large reductions in heat transfer rates, and that the film conditions constitute an appropriate reference state for the evaluation of thermophysical properties. The numerical results indicate that the blowing effect of evaporation on momentum transfer is to reduce friction drag very significantly but at the same time increase pressure drag by almost an equal amount; the net effect on the total drag force being only a marginal reduction. In all cases, it is found that thermophysical property variations play a very dominant role in reducing the drag forces acting on cold particles. Results are analysed and a correlation for stagnation-point heat transfer is also presented.
High pulse number thermal shock tests on tungsten with steady state particle background
Wirtz, M.; Kreter, A.; Linke, J.; Loewenhoff, Th; Pintsuk, G.; Sergienko, G.; Steudel, I.; Unterberg, B.; Wessel, E.
2017-12-01
Thermal fatigue of metallic materials, which will be exposed to severe environmental conditions e.g. plasma facing materials in future fusion reactors, is an important issue in order to predict the life time of complete wall components. Therefore experiments in the linear plasma device PSI-2 were performed to investigate the synergistic effects of high pulse number thermal shock events (L = 0.38 GW m-2, Δt = 0.5 ms) and stationary D/He (6%) plasma particle background on the thermal fatigue behavior of tungsten. Similar to experiments with pure thermal loads, the induced microstructural and surface modifications such as recrystallization and roughening as well as crack formation become more pronounced with increasing number of thermal shock events. However, the amount of damage significantly increases for synergistic loads showing severe surface roughening, plastic deformation and erosion resulting from the degradation of the mechanical properties caused by bombardment and diffusion of D/He to the surface and the bulk of the material. Additionally, D/He induced blistering and bubble formation were observed for all tested samples, which could change the thermal and mechanical properties of near surface regions.
Kr, Sreenivas; Prakash, Vivek N.; Arakeri, Jaywant H.
2010-11-01
We study the plume structure in high Rayleigh number convection in the limit of large Prandtl numbers. This regime is relevant in Mantle convection, where the plume dynamics is not well understood due to complex rheology and chemical composition. We use analogue laboratory experiments to mimic mantle convection. Our focus in this paper is to understand the role of viscosity ratio, U, between the plume fluid and the ambient fluid on the structure and dynamics of the plumes. The PLIF technique has been used to visualize the structures of plumes rising from a planar source of compositional buoyancy at different regimes of U (1/300 to 2500). In the near-wall planform when U is one, a well-known dendritic line plume structure is observed. As U increases (U > 1; mantle hot spots), there is a morphological transition from line plumes to discrete spherical blobs, accompanied by an increase in the plume spacing and thickness. In vertical sections, as U increases (U > 1), the plume head shape changes from a mushroom-like structure to a "spherical-blob." When the U is decreased below one, (U<1; subduction regime), the formation of cellular patterns is favoured with sheet plumes. Both velocity and mixing efficiency are maximum when U is one, and decreases for extreme values of U. We quantify the morphological changes, dynamics and mixing variations of the plumes from experiments at different regimes.
Numerical solution of the Navier--Stokes equations at high Reynolds numbers
Shestakov, A.I.
1974-01-01
A numerical method is presented which is designed to solve the Navier-Stokes equations for two-dimensional, incompressible flow. The method is intended for use on problems with high Reynolds numbers for which calculations via finite difference methods have been unattainable or unreliable. The proposed scheme is a hybrid utilizing a time-splitting finite difference method in areas away from the boundaries. In areas neighboring the boundaries, the equations of motion are solved by the newly proposed vortex method by Chorin. The major accomplishment of the new scheme is that it contains a simple way for merging the two methods at the interface of the two subdomains. The proposed algorithm is designed for use on the time-dependent equations but can be used on steady state problems as well. The method is tested on the popular, time-independent, square cavity problem, an example of a separated flow with closed streamlines. Numerical results are presented for a Reynolds number of 10 3 . (auth)
Jet Impingement Heat Transfer at High Reynolds Numbers and Large Density Variations
Jensen, Michael Vincent; Walther, Jens Honore
2010-01-01
Jet impingement heat transfer from a round gas jet to a flat wall has been investigated numerically in a configuration with H/D=2, where H is the distance from the jet inlet to the wall and D is the jet diameter. The jet Reynolds number was 361000 and the density ratio across the wall boundary...... layer was 3.3 due to a substantial temperature difference of 1600K between jet and wall. Results are presented which indicate very high heat flux levels and it is demonstrated that the jet inlet turbulence intensity significantly influences the heat transfer results, especially in the stagnation region....... The results also show a noticeable difference in the heat transfer predictions when applying different turbulence models. Furthermore calculations were performed to study the effect of applying temperature dependent thermophysical properties versus constant properties and the effect of calculating the gas...
Nick D.L. Owens
2016-01-01
Full Text Available Transcript regulation is essential for cell function, and misregulation can lead to disease. Despite technologies to survey the transcriptome, we lack a comprehensive understanding of transcript kinetics, which limits quantitative biology. This is an acute challenge in embryonic development, where rapid changes in gene expression dictate cell fate decisions. By ultra-high-frequency sampling of Xenopus embryos and absolute normalization of sequence reads, we present smooth gene expression trajectories in absolute transcript numbers. During a developmental period approximating the first 8 weeks of human gestation, transcript kinetics vary by eight orders of magnitude. Ordering genes by expression dynamics, we find that “temporal synexpression” predicts common gene function. Remarkably, a single parameter, the characteristic timescale, can classify transcript kinetics globally and distinguish genes regulating development from those involved in cellular metabolism. Overall, our analysis provides unprecedented insight into the reorganization of maternal and embryonic transcripts and redefines our ability to perform quantitative biology.
High-mode-number ballooning modes in a heliotron/torsatron system: 1, Local magnetic shear
Nakajima, N.
1996-05-01
The characteristics of the local magnetic shear, a quantity associated with high-mode-number ballooning mode stability, are considered in heliotron/torsatron devices that have a large Shafranov shift. The local magnetic shear is shown to vanish even in the stellarator-like region in which the global magnetic shear is positive. The reason for this is that the degree of the local compression of the poloidal magnetic field on the outer side of the torus, which maintains the toroidal force balance, is reduced in the stellarator-like region of global magnetic shear because the global rotational transform in heliotron/torsatron systems is a radially increasing function. This vanishing of the local magnetic shear is a universal property in heliotron/torsatron systems with a large Shafranov shift since it results from toroidal force balance in the stellarator-like global shear regime that is inherent to such systems
Dissipative particle dynamics of diffusion-NMR requires high Schmidt-numbers
Azhar, Mueed; Greiner, Andreas [Laboratory for Simulation, Department of Microsystems Engineering (IMTEK), University of Freiburg, Georges-Köhler-Allee 103, 79110 Freiburg (Germany); Korvink, Jan G., E-mail: jan.korvink@kit.edu, E-mail: david.kauzlaric@imtek.uni-freiburg.de [Laboratory for Simulation, Department of Microsystems Engineering (IMTEK), University of Freiburg, Georges-Köhler-Allee 103, 79110 Freiburg (Germany); Department of Microstructure Technology, Karlsruhe Institute of Technology, Hermann-von-Helmholtz-Platz 1, Eggenstein-Leopoldshafen (Germany); Kauzlarić, David, E-mail: jan.korvink@kit.edu, E-mail: david.kauzlaric@imtek.uni-freiburg.de [Laboratory for Simulation, Department of Microsystems Engineering (IMTEK), University of Freiburg, Georges-Köhler-Allee 103, 79110 Freiburg (Germany); Freiburg Institute for Advanced Studies, University of Freiburg, Albertstr. 19, 79104 Freiburg (Germany)
2016-06-28
We present an efficient mesoscale model to simulate the diffusion measurement with nuclear magnetic resonance (NMR). On the level of mesoscopic thermal motion of fluid particles, we couple the Bloch equations with dissipative particle dynamics (DPD). Thereby we establish a physically consistent scaling relation between the diffusion constant measured for DPD-particles and the diffusion constant of a real fluid. The latter is based on a splitting into a centre-of-mass contribution represented by DPD, and an internal contribution which is not resolved in the DPD-level of description. As a consequence, simulating the centre-of-mass contribution with DPD requires high Schmidt numbers. After a verification for fundamental pulse sequences, we apply the NMR-DPD method to NMR diffusion measurements of anisotropic fluids, and of fluids restricted by walls of microfluidic channels. For the latter, the free diffusion and the localisation regime are considered.
Dissipative Effects on Inertial-Range Statistics at High Reynolds Numbers.
Sinhuber, Michael; Bewley, Gregory P; Bodenschatz, Eberhard
2017-09-29
Using the unique capabilities of the Variable Density Turbulence Tunnel at the Max Planck Institute for Dynamics and Self-Organization, Göttingen, we report experimental measurements in classical grid turbulence that uncover oscillations of the velocity structure functions in the inertial range. This was made possible by measuring extremely long time series of up to 10^{10} samples of the turbulent fluctuating velocity, which corresponds to O(10^{7}) integral length scales. The measurements were conducted in a well-controlled environment at a wide range of high Reynolds numbers from R_{λ}=110 up to R_{λ}=1600, using both traditional hot-wire probes as well as the nanoscale thermal anemometry probe developed at Princeton University. An implication of the observed oscillations is that dissipation influences the inertial-range statistics of turbulent flows at scales significantly larger than predicted by current models and theories.
Constrained instanton and baryon number non-conservation at high energies
Sil'vestrov, P.G.
1992-01-01
The main subject of this paper is the calculation of corrections to instanton action ΔS∼(mρ) 4 log(mρ)/g 2 (ρ is the intanton radius) in the SU(2) Yang-Mills theory. The total cross section for baryon number violating processes at high energies is usually parametrized as σ tat ∝exp(4π/αF(ε)), where α=g 2 /4π, ε=√s/E 0 , E 0 =√6πm w /α. In the present paper the third nontrivial term of the F(ε) expansion is obtained. The unknown correction to F(ε) are expected to be of the order of ε 8/3 . The total cross section is extremely sensitive to the value of single instanton action. For sufficiently heavy Higgs boson the ρ-dependent part of the instanton action is changed drastically. 21 refs.; 1 fig
Pawar, Shashikant S.; Arakeri, Jaywant H.
2016-06-01
Kinetic energy and scalar spectra from the measurements in high Rayleigh number axially homogeneous buoyancy driven turbulent flow are presented. Kinetic energy and concentration (scalar) spectra are obtained from the experiments wherein density difference is created using brine and fresh water and temperature spectra are obtained from the experiments in which heat is used. Scaling of the frequency spectra of lateral and longitudinal velocity near the tube axis is closer to the Kolmogorov-Obukhov scaling, while the scalar spectra show some evidence of dual scaling, Bolgiano-Obukhov scaling followed by Obukhov-Corrsin scaling. These scalings are also observed in the corresponding second order spatial structure functions of velocity and concentration fluctuations.
Low-frequency modes with high toroidal mode numbers. A general formulation
Pegoraro, F.; Schep, T.J.
1979-09-01
Low-frequency waves with high toroidal mode numbers in an axisymmetric toroidal configuration are studied. In particular, the relationship between the periodicity constraints imposed by the geometry, magnetic shear and the spatial structure of eigenmodes is investigated. By exploiting the radial translational invariance and the poloidal periodicity of the gyrokinetic and Maxwell equations, the two-dimensional problem can be converted into a one-dimensional one and the mode structure can be expressed in terms of a single extended poloidal variable. This representation is used in the description of electromagnetic modes with phase velocities larger than the ion thermal velocity and with frequencies below the ion gyro-frequency. Trapped particle, curvature and compressional effects are retained. The dispersion equations for drift mode and Alfven-type modes are given in general geometry and simplified solutions are presented in the configuration of a double periodic plane slab. (Auth.)
Observations of high droplet number concentrations in Southern Ocean boundary layer clouds
T. Chubb
2016-01-01
Full Text Available Cloud physics data collected during the NSF/NCAR High-performance Instrumented Airborne Platform for Environmental Research (HIAPER Pole-to-Pole Observations (HIPPO campaigns provide a snapshot of unusual wintertime microphysical conditions in the boundary layer over the Southern Ocean. On 29 June 2011, the HIAPER sampled the boundary layer in a region of pre-frontal warm air advection between 58 and 48° S to the south of Tasmania. Cloud droplet number concentrations were consistent with climatological values in the northernmost profiles but were exceptionally high for wintertime in the Southern Ocean at 100–200 cm−3 in the southernmost profiles. Sub-micron (0.06 < D < 1 µm aerosol concentrations for the southern profiles were up to 400 cm−3. Analysis of back trajectories and atmospheric chemistry observations revealed that while conditions in the troposphere were more typical of a clean remote ocean airmass, there was some evidence of continental or anthropogenic influence. However, the hypothesis of long-range transport of continental aerosol fails to explain the magnitude of the aerosol and cloud droplet concentration in the boundary layer. Instead, the gale force surface winds in this case (wind speed at 167 m above sea level was > 25 m s−1 were most likely responsible for production of sea spray aerosol which influenced the microphysical properties of the boundary layer clouds. The smaller size and higher number concentration of cloud droplets is inferred to increase the albedo of these clouds, and these conditions occur regularly, and are expected to increase in frequency, over windy parts of the Southern Ocean.
Mitigation of naphthenate related production upsets in high TAN (Total Acid Number) crude oil
Ostojic, Nik [Maersk Oil, Copenhagen (Denmark); Vijn, Pieter; Reiners, Robert [Champion Technologies Europe BV, Delden (Netherlands)
2012-07-01
This paper describes a strategy for prediction, evaluation and mitigation of calcium naphthenate related production problems. Developing fields with acidic crude in the North Sea, West Africa, Bohai Bay (China) and Brazil is becoming more common in recent years. The high acid crude contains a considerable amount of naphthenic acids, typically having a Total Acid Number (TAN) higher than 0.5 mg KOH/g. Formation of either hard type 'calcium naphthenate precipitates' or soft type 'sodium carboxylate/emulsions' during crude oil production can lead to severe flow assurance and separation problems. In severe cases this may lead to production shutdowns to clean-up the equipment. A number of different naphthenate mitigation approaches have been published but no one particular approach is considered to be the most efficient as it depends significantly on the particular field conditions. Initially, this problem was addressed by deploying large volumes of (usually organic) acid, but more recently high efficiency low dose naphthenate inhibitors have been introduced. For predicting naphthenate scaling potential, methods were developed to determine the concentration of 1230 Dalton naphthenic tetra acid (ARN acids) in either deposit or crude oil and this information can be used to locate and potentially isolate the problem to a certain reservoir. Also, methods were developed to design suitable low dose naphthenate inhibitors. As these inhibitors are field tested, monitoring is required to ensure the product is performing most efficiently. In cases of tight emulsions however, this is less difficult as the oil dehydration and water quality is affected instantly. Methods were developed to allow monitoring of the calcium naphthenate deposition in field trails, thus allow trending and evaluation of the chemicals performance. After detailed analyses and discussions of the developed methods, a North Sea case history is presented reviewing several years of treating
Wang, Yuker; Carlton, Victoria E.H.; Karlin-Neumann, George; Sapolsky, Ronald; Zhang, Li; Moorhead, Martin; Wang, Zhigang C.; Richardson, Andrea L.; Warren, Robert; Walther, Axel; Bondy, Melissa; Sahin, Aysegul; Krahe, Ralf; Tuna, Musaffe; Thompson, Patricia A.; Spellman, Paul T.; Gray, Joe W.; Mills, Gordon B.; Faham, Malek
2009-02-24
A major challenge facing DNA copy number (CN) studies of tumors is that most banked samples with extensive clinical follow-up information are Formalin-Fixed Paraffin Embedded (FFPE). DNA from FFPE samples generally underperforms or suffers high failure rates compared to fresh frozen samples because of DNA degradation and cross-linking during FFPE fixation and processing. As FFPE protocols may vary widely between labs and samples may be stored for decades at room temperature, an ideal FFPE CN technology should work on diverse sample sets. Molecular Inversion Probe (MIP) technology has been applied successfully to obtain high quality CN and genotype data from cell line and frozen tumor DNA. Since the MIP probes require only a small ({approx}40 bp) target binding site, we reasoned they may be well suited to assess degraded FFPE DNA. We assessed CN with a MIP panel of 50,000 markers in 93 FFPE tumor samples from 7 diverse collections. For 38 FFPE samples from three collections we were also able to asses CN in matched fresh frozen tumor tissue. Using an input of 37 ng genomic DNA, we generated high quality CN data with MIP technology in 88% of FFPE samples from seven diverse collections. When matched fresh frozen tissue was available, the performance of FFPE DNA was comparable to that of DNA obtained from matched frozen tumor (genotype concordance averaged 99.9%), with only a modest loss in performance in FFPE. MIP technology can be used to generate high quality CN and genotype data in FFPE as well as fresh frozen samples.
GPU Implementation of High Rayleigh Number Three-Dimensional Mantle Convection
Sanchez, D. A.; Yuen, D. A.; Wright, G. B.; Barnett, G. A.
2010-12-01
Although we have entered the age of petascale computing, many factors are still prohibiting high-performance computing (HPC) from infiltrating all suitable scientific disciplines. For this reason and others, application of GPU to HPC is gaining traction in the scientific world. With its low price point, high performance potential, and competitive scalability, GPU has been an option well worth considering for the last few years. Moreover with the advent of NVIDIA's Fermi architecture, which brings ECC memory, better double-precision performance, and more RAM to GPU, there is a strong message of corporate support for GPU in HPC. However many doubts linger concerning the practicality of using GPU for scientific computing. In particular, GPU has a reputation for being difficult to program and suitable for only a small subset of problems. Although inroads have been made in addressing these concerns, for many scientists GPU still has hurdles to clear before becoming an acceptable choice. We explore the applicability of GPU to geophysics by implementing a three-dimensional, second-order finite-difference model of Rayleigh-Benard thermal convection on an NVIDIA GPU using C for CUDA. Our code reaches sufficient resolution, on the order of 500x500x250 evenly-spaced finite-difference gridpoints, on a single GPU. We make extensive use of highly optimized CUBLAS routines, allowing us to achieve performance on the order of O( 0.1 ) µs per timestep*gridpoint at this resolution. This performance has allowed us to study high Rayleigh number simulations, on the order of 2x10^7, on a single GPU.
A Sweeping Jet Application on a High Reynolds Number Semispan Supercritical Wing Configuration
Jones, Gregory S.; Milholen, William E., II; Chan, David T.; Melton, Latunia; Goodliff, Scott L.; Cagle, C. Mark
2017-01-01
The FAST-MAC circulation control model was modified to test an array of unsteady sweeping-jet actuators at realistic flight Reynolds numbers in the National Transonic Facility at the NASA Langley Research Center. Two types of sweeping jet actuators were fabricated using rapid prototype techniques, and directed over a 15% chord simple-hinged flap. The model was configured for low-speed high-lift testing with flap deflections of 30 deg and 60 deg, and a transonic cruise configuration having a 0 deg flap deflection. For the 30 deg flap high-lift configuration, the sweeping jets achieved comparable lift performance in the separation control regime, while reducing the mass flow by 54% as compared to steady blowing. The sweeping jets however were not effective for the 60 deg flap. For the transonic cruise configuration, the sweeping jets reduced the drag by 3.3% at an off-design condition. The drag reduction for the design lift coefficient for the sweeping jets offer is only half the drag reduction shown for the steady blowing case (6.5%), but accomplished this with a 74% reduction in mass flow.
Elbing, Brian R.; Winkel, Eric S.; Ceccio, Steven L.; Perlin, Marc; Dowling, David R.
2010-08-01
Wall-pressure fluctuations were investigated within a high-Reynolds-number turbulent boundary layer (TBL) modified by the addition of dilute friction-drag-reducing polymer solutions. The experiment was conducted at the U.S. Navy's Large Cavitation Channel on a 12.9 m long flat-plate test model with the surface hydraulically smooth (k+<0.2) and achieving downstream-distance-based Reynolds numbers to 220×106. The polymer (polyethylene oxide) solution was injected into the TBL through a slot in the surface. The primary flow diagnostics were skin-friction drag balances and an array of flush-mounted dynamic pressure transducers 9.8 m from the model leading edge. Parameters varied included the free-stream speed (6.7, 13.4, and 20.2 m s-1) and the injection condition (polymer molecular weight, injection concentration, and volumetric injection flux). The behavior of the pressure spectra, convection velocity, and coherence, regardless of the injection condition, were determined primarily based on the level of drag reduction. Results were divided into two regimes dependent on the level of polymer drag reduction (PDR), nominally separated at a PDR of 40%. The low-PDR regime is characterized by decreasing mean-square pressure fluctuations and increasing convection velocity with increasing drag reduction. This shows that the decrease in the pressure spectra with increasing drag reduction is due in part to the moving of the turbulent structures from the wall. Conversely, with further increases in drag reduction, the high-PDR regime has negligible variation in the mean-squared pressure fluctuations and convection velocity. The convection velocity remains constant at approximately 10% above the baseline-flow convection velocity, which suggests that the turbulent structures no longer move farther from the wall with increasing drag reduction. In light of recent numerical work, the coherence results indicate that in the low-PDR regime, the turbulent structures are being elongated in
Ground Boundary Conditions for Thermal Convection Over Horizontal Surfaces at High Rayleigh Numbers
Hanjalić, K.; Hrebtov, M.
2016-07-01
We present "wall functions" for treating the ground boundary conditions in the computation of thermal convection over horizontal surfaces at high Rayleigh numbers using coarse numerical grids. The functions are formulated for an algebraic-flux model closed by transport equations for the turbulence kinetic energy, its dissipation rate and scalar variance, but could also be applied to other turbulence models. The three-equation algebraic-flux model, solved in a T-RANS mode ("Transient" Reynolds-averaged Navier-Stokes, based on triple decomposition), was shown earlier to reproduce well a number of generic buoyancy-driven flows over heated surfaces, albeit by integrating equations up to the wall. Here we show that by using a set of wall functions satisfactory results are found for the ensemble-averaged properties even on a very coarse computational grid. This is illustrated by the computations of the time evolution of a penetrative mixed layer and Rayleigh-Bénard (open-ended, 4:4:1 domain) convection, using 10 × 10 × 100 and 10 × 10 × 20 grids, compared also with finer grids (e.g. 60 × 60 × 100), as well as with one-dimensional treatment using 1 × 1 × 100 and 1 × 1 × 20 nodes. The approach is deemed functional for simulations of a convective boundary layer and mesoscale atmospheric flows, and pollutant transport over realistic complex hilly terrain with heat islands, urban and natural canopies, for diurnal cycles, or subjected to other time and space variations in ground conditions and stratification.
Chakraborty, Brahmananda
2009-01-01
Random number plays an important role in any Monte Carlo simulation. The accuracy of the results depends on the quality of the sequence of random numbers employed in the simulation. These include randomness of the random numbers, uniformity of their distribution, absence of correlation and long period. In a typical Monte Carlo simulation of particle transport in a nuclear reactor core, the history of a particle from its birth in a fission event until its death by an absorption or leakage event is tracked. The geometry of the core and the surrounding materials are exactly modeled in the simulation. To track a neutron history one needs random numbers for determining inter collision distance, nature of the collision, the direction of the scattered neutron etc. Neutrons are tracked in batches. In one batch approximately 2000-5000 neutrons are tracked. The statistical accuracy of the results of the simulation depends on the total number of particles (number of particles in one batch multiplied by the number of batches) tracked. The number of histories to be generated is usually large for a typical radiation transport problem. To track a very large number of histories one needs to generate a long sequence of independent random numbers. In other words the cycle length of the random number generator (RNG) should be more than the total number of random numbers required for simulating the given transport problem. The number of bits of the machine generally limits the cycle length. For a binary machine of p bits the maximum cycle length is 2 p . To achieve higher cycle length in the same machine one has to use either register arithmetic or bit manipulation technique
High-resolution copy-number variation map reflects human olfactory receptor diversity and evolution.
Yehudit Hasin
2008-11-01
Full Text Available Olfactory receptors (ORs, which are involved in odorant recognition, form the largest mammalian protein superfamily. The genomic content of OR genes is considerably reduced in humans, as reflected by the relatively small repertoire size and the high fraction ( approximately 55% of human pseudogenes. Since several recent low-resolution surveys suggested that OR genomic loci are frequently affected by copy-number variants (CNVs, we hypothesized that CNVs may play an important role in the evolution of the human olfactory repertoire. We used high-resolution oligonucleotide tiling microarrays to detect CNVs across 851 OR gene and pseudogene loci. Examining genomic DNA from 25 individuals with ancestry from three populations, we identified 93 OR gene loci and 151 pseudogene loci affected by CNVs, generating a mosaic of OR dosages across persons. Our data suggest that approximately 50% of the CNVs involve more than one OR, with the largest CNV spanning 11 loci. In contrast to earlier reports, we observe that CNVs are more frequent among OR pseudogenes than among intact genes, presumably due to both selective constraints and CNV formation biases. Furthermore, our results show an enrichment of CNVs among ORs with a close human paralog or lacking a one-to-one ortholog in chimpanzee. Interestingly, among the latter we observed an enrichment in CNV losses over gains, a finding potentially related to the known diminution of the human OR repertoire. Quantitative PCR experiments performed for 122 sampled ORs agreed well with the microarray results and uncovered 23 additional CNVs. Importantly, these experiments allowed us to uncover nine common deletion alleles that affect 15 OR genes and five pseudogenes. Comparison to the chimpanzee reference genome revealed that all of the deletion alleles are human derived, therefore indicating a profound effect of human-specific deletions on the individual OR gene content. Furthermore, these deletion alleles may be used
Influence of elbow curvature on flow structure at elbow outlet under high Reynolds number condition
Ono, A., E-mail: ono.ayako@jaea.go.jp [Oarai Research and Development Center, Japan Atomic Energy Agency, Narita 4002, Oarai, Ibaraki 311-1393 (Japan); Kimura, N.; Kamide, H.; Tobita, A. [Oarai Research and Development Center, Japan Atomic Energy Agency, Narita 4002, Oarai, Ibaraki 311-1393 (Japan)
2011-11-15
In the design of Japan Sodium-cooled Fast Reactor (JSFR), coolant velocity is beyond 9 m/s in the primary hot leg pipe of 1.27 m diameter. The Reynolds number in the piping reaches 4.2 Multiplication-Sign 10{sup 7}. Moreover, a short-elbow is adopted in the hot leg pipe in order to achieve compact plant layout and to reduce plant construction cost. Therefore, the flow-induced vibration (FIV) arising from the piping geometry may occur in the short-elbow pipe. The FIV is due to the excitation source which is caused by the pressure fluctuation in the pipe. The pressure fluctuation in the pipe is closely related with the velocity fluctuation. As the first step of clarification of the FIV mechanism, it is important to grasp the mechanism of flow fluctuation in the elbow. In this study, water experiments with two types of elbows with different curvature ratios were conducted in order to investigate the interaction between flow separation and the secondary flow due to the elbow curvature. The experiments were conducted with the short-elbow and the long-elbow under Re = 1.8 Multiplication-Sign 10{sup 5} and 5.4 Multiplication-Sign 10{sup 5} conditions. The velocity fields in the elbows were measured using a high-speed Particle Image Velocimetry (PIV). The time-series of axial velocity fields and the cross-section velocity fields obtained by the high-speed PIV measurements revealed the unsteady and complex flow structure in the elbow. The flow separation always occurred in the short-elbow while the flow separation occurred intermittently in the long-elbow case. The circumferential secondary flows in clockwise and counterclockwise directions flowed forward downstream of reattachment point alternately in both elbows.
Linear drag law for high-Reynolds-number flow past an oscillating body
Agre, Natalie; Childress, Stephen; Zhang, Jun; Ristroph, Leif
2016-07-01
An object immersed in a fast flow typically experiences fluid forces that increase with the square of speed. Here we explore how this high-Reynolds-number force-speed relationship is affected by unsteady motions of a body. Experiments on disks that are driven to oscillate while progressing through air reveal two distinct regimes: a conventional quadratic relationship for slow oscillations and an anomalous scaling for fast flapping in which the time-averaged drag increases linearly with flow speed. In the linear regime, flow visualization shows that a pair of counterrotating vortices is shed with each oscillation and a model that views a train of such dipoles as a momentum jet reproduces the linearity. We also show that appropriate scaling variables collapse the experimental data from both regimes and for different oscillatory motions into a single drag-speed relationship. These results could provide insight into the aerodynamic resistance incurred by oscillating wings in flight and they suggest that vibrations can be an effective means to actively control the drag on an object.
High Reynolds number rough wall turbulent boundary layer experiments using Braille surfaces
Harris, Michael; Monty, Jason; Nova, Todd; Allen, James; Chong, Min
2007-11-01
This paper details smooth, transitional and fully rough turbulent boundary layer experiments in the New Mexico State high Reynolds number rough wall wind tunnel. The initial surface tested was generated with a Braille printer and consisted of an uniform array of Braille points. The average point height being 0.5mm, the spacing between the points in the span was 0.5mm and the surface consisted of span wise rows separated by 4mm. The wavelength to peak ratio was 8:1. The boundary layer thickness at the measurement location was 190mm giving a large separation of roughness height to layer thickness. The maximum friction velocity was uτ=1.5m/s at Rex=3.8 x10^7. Results for the skin friction co-efficient show that this surface follows a Nikuradse type inflectional curve and that Townsends outer layer similarity hypothesis is valid for rough wall flows with a large separation of scales. Mean flow and turbulence statistics will be presented.
The effect of tip speed ratio on a vertical axis wind turbine at high Reynolds numbers
Parker, Colin M.; Leftwich, Megan C.
2016-05-01
This work visualizes the flow surrounding a scaled model vertical axis wind turbine at realistic operating conditions. The model closely matches geometric and dynamic properties—tip speed ratio and Reynolds number—of a full-size turbine. The flow is visualized using particle imaging velocimetry (PIV) in the midplane upstream, around, and after (up to 4 turbine diameters downstream) the turbine, as well as a vertical plane behind the turbine. Time-averaged results show an asymmetric wake behind the turbine, regardless of tip speed ratio, with a larger velocity deficit for a higher tip speed ratio. For the higher tip speed ratio, an area of averaged flow reversal is present with a maximum reverse flow of -0.04U_∞. Phase-averaged vorticity fields—achieved by syncing the PIV system with the rotation of the turbine—show distinct structures form from each turbine blade. There were distinct differences in results by tip speed ratios of 0.9, 1.3, and 2.2 of when in the cycle structures are shed into the wake—switching from two pairs to a single pair of vortices being shed—and how they convect into the wake—the middle tip speed ratio vortices convect downstream inside the wake, while the high tip speed ratio pair is shed into the shear layer of the wake. Finally, results show that the wake structure is much more sensitive to changes in tip speed ratio than to changes in Reynolds number.
Conditional analysis near strong shear layers in DNS of isotropic turbulence at high Reynolds number
Ishihara, Takashi; Kaneda, Yukio [Graduate School of Engineering, Nagoya University (Japan); Hunt, Julian C R, E-mail: ishihara@cse.nagoya-u.ac.jp [University College of London (United Kingdom)
2011-12-22
Data analysis of high resolution DNS of isotropic turbulence with the Taylor scale Reynolds number R{sub {lambda}} = 1131 shows that there are thin shear layers consisting of a cluster of strong vortex tubes with typical diameter of order 10{eta}, where {eta} is the Kolmogorov length scale. The widths of the layers are of the order of the Taylor micro length scale. According to the analysis of one of the layers, coarse grained vorticity in the layer are aligned approximately in the plane of the layer so that there is a net mean shear across the layer with a mean velocity jump of the order of the root-mean-square of the fluctuating velocity, and energy dissipation averaged over the layer is larger than ten times the average over the whole flow. The mean and the standard deviation of the energy transfer T(x, {kappa}) from scales larger than 1/{kappa} to scales smaller than 1/{kappa} at position x are largest within the layers (where the most intense vortices and dissipation occur), but are also large just outside the layers (where viscous stresses are weak), by comparison with the average values of T over the whole region. The DNS data are consistent with exterior fluctuation being damped/filtered at the interface of the layer and then selectively amplified within the layer.
Jones, Gregory S.; Milholen, William E., II; Fell, Jared S.; Webb, Sandy R.; Cagle, C. Mark
2016-01-01
The application of a sweeping jet actuator to a circulation control system was initiated by a risk reduction series of experiments to optimize the authority of a single sweeping jet actuator. The sweeping jet design was integrated into the existing Fundamental Aerodynamic Subsonic Transonic- Modular Active Control (FAST-MAC) model by replacing the steady blowing system with an array of thirty-nine sweeping jet cartridges. A constant slot height to wing chord ratio was similar to the steady blowing configuration resulting in each actuator having a unique in size for the sweeping jet configuration. While this paper will describe the scaling and optimization of the actuators for future high Reynolds number applications, the major focus of this effort was to target the transonic flight regime by increasing the amplitude authority of the actuator. This was accomplished by modifying the diffuser of the sweeping jet actuator, and this paper highlights twelve different diffuser designs. The experimental portion of this work was completed in the NASA Langley National Transonic Facility.
Scaling and interaction of self-similar modes in models of high Reynolds number wall turbulence.
Sharma, A S; Moarref, R; McKeon, B J
2017-03-13
Previous work has established the usefulness of the resolvent operator that maps the terms nonlinear in the turbulent fluctuations to the fluctuations themselves. Further work has described the self-similarity of the resolvent arising from that of the mean velocity profile. The orthogonal modes provided by the resolvent analysis describe the wall-normal coherence of the motions and inherit that self-similarity. In this contribution, we present the implications of this similarity for the nonlinear interaction between modes with different scales and wall-normal locations. By considering the nonlinear interactions between modes, it is shown that much of the turbulence scaling behaviour in the logarithmic region can be determined from a single arbitrarily chosen reference plane. Thus, the geometric scaling of the modes is impressed upon the nonlinear interaction between modes. Implications of these observations on the self-sustaining mechanisms of wall turbulence, modelling and simulation are outlined.This article is part of the themed issue 'Toward the development of high-fidelity models of wall turbulence at large Reynolds number'. © 2017 The Author(s).
NUMERICAL SIMULATIONS OF FLOW BEHAVIOR IN DRIVEN CAVITY AT HIGH REYNOLDS NUMBERS
Fudhail Bin Abdul Munir
2012-02-01
Full Text Available In recent years, due to rapidly increasing computational power, computational methods have become the essential tools to conduct researches in various engineering fields. In parallel to the development of ultra high speed digital computers, computational fluid dynamics (CFD has become the new third approach apart from theory and experiment in the philosophical study and development of fluid dynamics. Lattice Boltzmann method (LBM is an alternative method to conventional CFD. LBM is relatively new approach that uses simple microscopic models to simulate complicated microscopic behavior of transport phenomena. In this paper, fluid flow behaviors of steady incompressible flow inside lid driven square cavity are studied. Numerical calculations are conducted for different Reynolds numbers by using Lattice Boltzmann scheme. The objective of the paper is to demonstrate the capability of this lattice Boltzmann scheme for engineering applications particularly in fluid transport phenomena. Keywords-component; lattice Boltzmann method, lid driven cavity, computational fluid dynamics.
Zhang, Xinjie; He, Peng; Tao, Yong; Yang, Yi
2013-11-04
High-level expression system of heterologous protein mediated by internal ribosome entry site (IRES) in Saccharomyces cerevisiae was constructed, which could be used for other applications of S. cerevisiae in metabolic engineering. We constructed co-expression cassette (promoter-mCherry-TIF4631 IRES-URA3) containing promoters Pilv5, Padh2 and Ptdh3 and recombined the co-expression cassette into the genome of W303-1B-A. The URA3+ transformants were selected. By comparing the difference in the mean florescence value of mCherry in transformants, the effect of three promoters was detected in the co-expression cassette. The copy numbers of the interested genes in the genome were determined by Real-Time PCR. We analyzed genetic stability by continuous subculturing transformants in the absence of selection pressure. To verify the application of co-expression cassette, the ORF of mCherry was replaced by beta-galactosidase (LACZ) and xylose reductase (XYL1). The enzyme activities and production of beta-galactosidase and xylose reductase were detected. mCherry has been expressed in the highest-level in transformants with co-expression cassette containing Pilv5 promoter. The highest copy number of DNA fragment integrating in the genome was 47 in transformants containing Pilv5. The engineering strains showed good genetic stability. Xylose reductase was successfully expressed in the co-expression cassette containing Pilv5 promoter and TIF4631 IRES. The highest enzyme activity was 0. 209 U/mg crude protein in the transformants WIX-10. Beta-galactosidase was also expressed successfully. The transformants that had the highest enzyme activity was WIL-1 and the enzyme activity was 12.58 U/mg crude protein. The system mediated by Pilv5 promoter and TIF4631 IRES could express heterologous protein efficiently in S. cerevisiae. This study offered a new strategy for expression of heterologous protein in S. cerevisiae and provided sufficient experimental evidence for metabolic engineering
Gai, Xiaowu; Perin, Juan C; Murphy, Kevin; O'Hara, Ryan; D'arcy, Monica; Wenocur, Adam; Xie, Hongbo M; Rappaport, Eric F; Shaikh, Tamim H; White, Peter S
2010-02-04
Recent studies have shown that copy number variations (CNVs) are frequent in higher eukaryotes and associated with a substantial portion of inherited and acquired risk for various human diseases. The increasing availability of high-resolution genome surveillance platforms provides opportunity for rapidly assessing research and clinical samples for CNV content, as well as for determining the potential pathogenicity of identified variants. However, few informatics tools for accurate and efficient CNV detection and assessment currently exist. We developed a suite of software tools and resources (CNV Workshop) for automated, genome-wide CNV detection from a variety of SNP array platforms. CNV Workshop includes three major components: detection, annotation, and presentation of structural variants from genome array data. CNV detection utilizes a robust and genotype-specific extension of the Circular Binary Segmentation algorithm, and the use of additional detection algorithms is supported. Predicted CNVs are captured in a MySQL database that supports cohort-based projects and incorporates a secure user authentication layer and user/admin roles. To assist with determination of pathogenicity, detected CNVs are also annotated automatically for gene content, known disease loci, and gene-based literature references. Results are easily queried, sorted, filtered, and visualized via a web-based presentation layer that includes a GBrowse-based graphical representation of CNV content and relevant public data, integration with the UCSC Genome Browser, and tabular displays of genomic attributes for each CNV. To our knowledge, CNV Workshop represents the first cohesive and convenient platform for detection, annotation, and assessment of the biological and clinical significance of structural variants. CNV Workshop has been successfully utilized for assessment of genomic variation in healthy individuals and disease cohorts and is an ideal platform for coordinating multiple associated
Rappaport Eric F
2010-02-01
Full Text Available Abstract Background Recent studies have shown that copy number variations (CNVs are frequent in higher eukaryotes and associated with a substantial portion of inherited and acquired risk for various human diseases. The increasing availability of high-resolution genome surveillance platforms provides opportunity for rapidly assessing research and clinical samples for CNV content, as well as for determining the potential pathogenicity of identified variants. However, few informatics tools for accurate and efficient CNV detection and assessment currently exist. Results We developed a suite of software tools and resources (CNV Workshop for automated, genome-wide CNV detection from a variety of SNP array platforms. CNV Workshop includes three major components: detection, annotation, and presentation of structural variants from genome array data. CNV detection utilizes a robust and genotype-specific extension of the Circular Binary Segmentation algorithm, and the use of additional detection algorithms is supported. Predicted CNVs are captured in a MySQL database that supports cohort-based projects and incorporates a secure user authentication layer and user/admin roles. To assist with determination of pathogenicity, detected CNVs are also annotated automatically for gene content, known disease loci, and gene-based literature references. Results are easily queried, sorted, filtered, and visualized via a web-based presentation layer that includes a GBrowse-based graphical representation of CNV content and relevant public data, integration with the UCSC Genome Browser, and tabular displays of genomic attributes for each CNV. Conclusions To our knowledge, CNV Workshop represents the first cohesive and convenient platform for detection, annotation, and assessment of the biological and clinical significance of structural variants. CNV Workshop has been successfully utilized for assessment of genomic variation in healthy individuals and disease cohorts and
Consequences of high effective Prandtl number on solar differential rotation and convective velocity
Karak, Bidya Binay; Miesch, Mark; Bekki, Yuto
2018-04-01
Observations suggest that the large-scale convective velocities obtained by solar convection simulations might be over-estimated (convective conundrum). One plausible solution to this could be the small-scale dynamo which cannot be fully resolved by global simulations. The small-scale Lorentz force suppresses the convective motions and also the turbulent mixing of entropy between upflows and downflows, leading to a large effective Prandtl number (Pr). We explore this idea in three-dimensional global rotating convection simulations at different thermal conductivity (κ), i.e., at different Pr. In agreement with previous non-rotating simulations, the convective velocity is reduced with the increase of Pr as long as the thermal conductive flux is negligible. A subadiabatic layer is formed near the base of the convection zone due to continuous deposition of low entropy plumes in low-κ simulations. The most interesting result of our low-κ simulations is that the convective motions are accompanied by a change in the convection structure that is increasingly influenced by small-scale plumes. These plumes tend to transport angular momentum radially inward and thus establish an anti-solar differential rotation, in striking contrast to the solar rotation profile. If such low diffusive plumes, driven by the radiative-surface cooling, are present in the Sun, then our results cast doubt on the idea that a high effective Pr may be a viable solution to the solar convective conundrum. Our study also emphasizes that any resolution of the conundrum that relies on the downward plumes must take into account the angular momentum transport and heat transport.
Ultimate regime of high Rayleigh number convection in a porous medium.
Hewitt, Duncan R; Neufeld, Jerome A; Lister, John R
2012-06-01
Well-resolved direct numerical simulations of 2D Rayleigh-Bénard convection in a porous medium are presented for Rayleigh numbers Ra≤4×10(4) which reveal that, contrary to previous indications, the linear classical scaling for the Nusselt number, Nu~Ra, is attained asymptotically. The flow dynamics are analyzed, and the interior of the vigorously convecting system is shown to be increasingly well described as Ra→∞ by a simple columnar "heat-exchanger" model with a single horizontal wave number k and a linear background temperature field. The numerical results are approximately fitted by k~Ra(0.4).
Ma, Tengfei; Chen, Ran; Dunlap, Susan; Chen, Baoguo
2016-01-01
This paper presents the results of an experiment that investigated the effects of number and presentation order of high-constraint sentences on semantic processing of unknown second language (L2) words (pseudowords) through reading. All participants were Chinese native speakers who learned English as a foreign language. In the experiment, sentence constraint and order of different constraint sentences were manipulated in English sentences, as well as L2 proficiency level of participants. We found that the number of high-constraint sentences was supportive for L2 word learning except in the condition in which high-constraint exposure was presented first. Moreover, when the number of high-constraint sentences was the same, learning was significantly better when the first exposure was a high-constraint exposure. And no proficiency level effects were found. Our results provided direct evidence that L2 word learning benefited from high quality language input and first presentations of high quality language input.
Excitable dynamics in high-Lewis number premixed gas combustion at normal and microgravity
Pearlman, Howard
1995-01-01
Freely-propagating, premixed gas flames in high-Lewis (Le) number, quiescent mixtures are studied experimentally in tubes of various diameter at normal (lg) and microgravity (mu g). A premixture of lean butane and oxygen diluted with helium, argon, neon, nitrogen or a mixture of multiple diluents is examined such that the thermal diffusivity of the mixture (and to a lesser extent, the mass diffusivity of the rate-limiting component) is systematically varied. In effect, different diluents allow variation of the Le without changing the chemistry. The flames are recorded with high speed cinematography and their stability is visually assessed. Different modes of propagation were observed depending on the diameter of the tubes (different conductive heat loss), the composition of the mixture and the g-level. At 1g, four modes of propagation were observed in small and intermediate diameter tubes (large conductive heat loss): (1) steadily propagating flames, (2) radial and longitudinal pulsating flames, (3) 'wavering' flames, and (4) rotating spiral flames. As the diameter of the tube increases, the radial modes become more pronounced while the longitudinal modes systematically disappear. Also, multiple, simultaneous, spatially-separated 'pacemaker' sites are observed in intermediate and large diameter tubes. Each site starts as a small region of high luminosity and develops into a flamelet which assumes the form of one of the fore mentioned modes. These flamelets eventually interact, annihilate each other in their regions of intersection and merge at their newly created free-ends. For very large tubes, radially-propagating wave-trains (believed to be 'trigger waves') are observed. These are analogous to the radial pulsations observed in the smaller diameter tubes. At mu g, three modes of propagation have been observed: (1) steadily propagating flames, (2) radial and longitudinal pulsating flames, and (3) multi-armed, rotating flames. Since the pulsating mode exists at mu
Inferring Variation in Copy Number Using High Throughput Sequencing Data in R.
Knaus, Brian J; Grünwald, Niklaus J
2018-01-01
Inference of copy number variation presents a technical challenge because variant callers typically require the copy number of a genome or genomic region to be known a priori . Here we present a method to infer copy number that uses variant call format (VCF) data as input and is implemented in the R package vcfR . This method is based on the relative frequency of each allele (in both genic and non-genic regions) sequenced at heterozygous positions throughout a genome. These heterozygous positions are summarized by using arbitrarily sized windows of heterozygous positions, binning the allele frequencies, and selecting the bin with the greatest abundance of positions. This provides a non-parametric summary of the frequency that alleles were sequenced at. The method is applicable to organisms that have reference genomes that consist of full chromosomes or sub-chromosomal contigs. In contrast to other software designed to detect copy number variation, our method does not rely on an assumption of base ploidy, but instead infers it. We validated these approaches with the model system of Saccharomyces cerevisiae and applied it to the oomycete Phytophthora infestans , both known to vary in copy number. This functionality has been incorporated into the current release of the R package vcfR to provide modular and flexible methods to investigate copy number variation in genomic projects.
Wang, Kai; He, Jie; Ding, Jianxun; Shi, Qin; Wang, Changjun; Li, Pingfan
2016-01-01
Objectives Road traffic crashes that involve very high numbers of fatalities and injuries arouse public concern wherever they occur. In China, there are two categories of such crashes: a crash that results in 10–30 fatalities, 50–100 serious injuries or a total cost of 50–100 million RMB ($US8-16m) is a “serious road traffic crash” (SRTC), while a crash that is even more severe or costly is a “particularly serious road traffic crash” (PSRTC). The aim of this study is to identify the main factors affecting different types of these crashes (single-vehicle, head-on, rear-end and side impact) with the ultimate goal of informing prevention activities and policies. Methods Detailed descriptions of the SRTCs and PSRTCs that occurred from 2007 to 2014 were collected from the database “In-depth Investigation and Analysis System for Major Road Traffic Crashes” (IIASMRTC), which is maintained by the Traffic Management Research Institute of the Ministry of Public Security of China (TMRI). 18 main risk factors, which were categorized into four areas (participant, vehicle, road and environment-related) were chosen as potential independent variables for the multinomial logistic regression analysis. Comparisons were made among the single-vehicle, head-on, rear-end and side impact crashes in terms of factors affecting crash occurrence. Findings Five risk factors were significant for the six multinomial logistic regression models, which were location, vertical alignment, roadside safety rating, driver distraction and overloading of cargo. It was indicated that intersections were more likely to have side impact SRTCs and PSRTCs, especially with poor visibility at night. Overloaded freight vehicles were more likely to be involved in a rear-end crash than other freight vehicles. Driver distraction is an important risk factor for head-on crashes, while vertical alignment and roadside safety rating are positively associated with single-vehicle crashes. Conclusion Based
High School Timetabling: Modeling and solving a large number of cases in Denmark
Sørensen, Matias; Stidsen, Thomas Riis
2012-01-01
for high school administration (available only for Danish high schools), which includes an embedded application for creating a weekly timetable. Currently, 230 high schools are customers of Lectio, and 191 have bought access to the timetabling software. This constitutes the majority of high schools...
Schaefer, Jennifer L.; Yanga, Dennis A.; Archer, Lynden A.
2013-01-01
High lithium transference number, tLi+, electrolytes are desired for use in both lithium-ion and lithium metal rechargeable battery technologies. Historically, low tLi+ electrolytes have hindered device performance by allowing ion concentration
Discrete-Roughness-Element-Enhanced Swept-Wing Natural Laminar Flow at High Reynolds Numbers
Malik, Mujeeb; Liao, Wei; Li, Fei; Choudhari, Meelan
2015-01-01
Nonlinear parabolized stability equations and secondary-instability analyses are used to provide a computational assessment of the potential use of the discrete-roughness-element technology for extending swept-wing natural laminar flow at chord Reynolds numbers relevant to transport aircraft. Computations performed for the boundary layer on a natural-laminar-flow airfoil with a leading-edge sweep angle of 34.6 deg, freestream Mach number of 0.75, and chord Reynolds numbers of 17 × 10(exp 6), 24 × 10(exp 6), and 30 × 10(exp 6) suggest that discrete roughness elements could delay laminar-turbulent transition by about 20% when transition is caused by stationary crossflow disturbances. Computations show that the introduction of small-wavelength stationary crossflow disturbances (i.e., discrete roughness element) also suppresses the growth of most amplified traveling crossflow disturbances.
DRE-Enhanced Swept-Wing Natural Laminar Flow at High Reynolds Numbers
Malik, Mujeeb; Liao, Wei; Li, Fe; Choudhari, Meelan
2013-01-01
Nonlinear parabolized stability equations and secondary instability analyses are used to provide a computational assessment of the potential use of the discrete roughness elements (DRE) technology for extending swept-wing natural laminar flow at chord Reynolds numbers relevant to transport aircraft. Computations performed for the boundary layer on a natural laminar flow airfoil with a leading-edge sweep angle of 34.6deg, free-stream Mach number of 0.75 and chord Reynolds numbers of 17 x 10(exp 6), 24 x 10(exp 6) and 30 x 10(exp 6) suggest that DRE could delay laminar-turbulent transition by about 20% when transition is caused by stationary crossflow disturbances. Computations show that the introduction of small wavelength stationary crossflow disturbances (i.e., DRE) also suppresses the growth of most amplified traveling crossflow disturbances.
The multifractal nature of plume structure in high-Rayleigh-number convection
Puthenveettil, Baburaj A.; Ananthakrishna, G.; Arakeri, Jaywant H.
2005-03-01
The geometrically different planforms of near-wall plume structure in turbulent natural convection, visualized by driving the convection using concentration differences across a membrane, are shown to have a common multifractal spectrum of singularities for Rayleigh numbers in the range 1010-1011 at Schmidt number of 602. The scaling is seen for a length scale range of 25 and is independent of the Rayleigh number, the flux, the strength and nature of the large-scale flow, and the aspect ratio. Similar scaling is observed for the plume structures obtained in the presence of a weak flow across the membrane. This common non-trivial spatial scaling is proposed to be due to the same underlying generating process for the near-wall plume structures.
Introduction: Scaling and structure in high Reynolds number wall-bounded flows
McKeon, B.J.; Sreenivasan, K.R.
2007-05-01
The papers discussed in this report are dealing with the following aspects: Fundamental scaling relations for canonical flows and asymptotic approach to infinite Reynolds numbers; large and very large scales in near-wall turbulences; the influence of roughness and finite Reynolds number effects; comparison between internal and external flows and the universality of the near-wall region; qualitative and quantitative models of the turbulent boundary layer; the neutrally stable atmospheric surface layer as a model for a canonical zero-pressure-gradient boundary layer (author)
A portable high-quality random number generator for lattice field theory simulations
Luescher, M.
1993-09-01
The theory underlying a proposed random number generator for numerical simulations in elementary particle physics and statistical mechanics is discussed. The generator is based on an algorithm introduced by Marsaglia and Zaman, with an important added feature leading to demonstrably good statistical properties. It can be implemented exactly on any computer complying with the IEEE-754 standard for single precision floating point arithmetic. (orig.)
The evolution of the flame surface in turbulent premixed jet flames at high Reynolds number
Luca, Stefano; Attili, Antonio; Bisetti, Fabrizio
2017-11-01
A set of direct numerical simulations of turbulent premixed flames in a spatially developing turbulent slot burner at four Reynolds number is presented. This configuration is of interest since it displays turbulent production by mean shear as in real combustion devices. The gas phase hydrodynamics are modeled with the reactive, unsteady Navier-Stokes equations in the low Mach number limit, with finite-rate chemistry consisting of 16 species and 73 reactions. For the highest jet Reynolds number of 22 ×103, 22 Billion grid points are employed. The jet consists of a lean methane/air mixture at 4 atm and preheated to 800 K. The analysis of stretch statistics shows that the mean total stretch is close to zero. Mean stretch decreases moving downstream from positive to negative values, suggesting a formation of surface area in the near field and destruction at the tip of the flame; the mean contribution of the tangential strain term is positive, while the mean contribution of the propagative term is always negative. Positive values of stretch are due to the tangential strain rate term, while large negative values are associated with the propagative term. Increasing Reynolds number is found to decrease the correlation between stretch and the single contributions.
Comminal, Raphaël; Spangenberg, Jon; Hattel, Jesper Henri
2015-01-01
potential of the velocity field, and provides a pressureless formulation of the conservation laws, which automatically enforces the incompressibility. The resulting numerical method is free from velocity-pressure decoupling errors, and can achieve stable calculations for large Courant numbers, which improve...
High and Low Reynolds number Measurements in a Room with an Impinging Isothermal Jet
Skovgaard, M.; Hyldgaard, C. E.; Nielsen, Peter V.
The present paper, which is within the work of the lEA - annex 20, presents a series of full-scale velocity measurements in a room with isothermal mixing ventilation. The measurements are in the Reynolds number range 1000 - 7000 based on inlet dimensions. This means that a transition from laminar...
Huang Yimin; Bhattacharjee, A.
2010-01-01
The Sweet-Parker layer in a system that exceeds a critical value of the Lundquist number (S) is unstable to the plasmoid instability. In this paper, a numerical scaling study has been done with an island coalescing system driven by a low level of random noise. In the early stage, a primary Sweet-Parker layer forms between the two coalescing islands. The primary Sweet-Parker layer breaks into multiple plasmoids and even thinner current sheets through multiple levels of cascading if the Lundquist number is greater than a critical value S c ≅4x10 4 . As a result of the plasmoid instability, the system realizes a fast nonlinear reconnection rate that is nearly independent of S, and is only weakly dependent on the level of noise. The number of plasmoids in the linear regime is found to scales as S 3/8 , as predicted by an earlier asymptotic analysis [N. F. Loureiro et al., Phys. Plasmas 14, 100703 (2007)]. In the nonlinear regime, the number of plasmoids follows a steeper scaling, and is proportional to S. The thickness and length of current sheets are found to scale as S -1 , and the local current densities of current sheets scale as S -1 . Heuristic arguments are given in support of theses scaling relations.
High Resolution Ultrasound Imaging Using Adaptive Beamforming with Reduced Number of Active Elements
Holfort, Iben Kraglund; Gran, Fredrik; Jensen, Jørgen Arendt
2009-01-01
is proposed. By reducing the number of active sensor elements, an increased resolution can be obtained with the MV beamformer. This observation is directly opposite the well-known relation between the spatial extent of the aperture and the achievable resolution. The investigations are based on Field II...
Muons in air showers at the Pierre Auger Observatory: Mean number in highly inclined events
Aab, A.; Abreu, P.; Aglietta, M.; Ahn, E. J.; Al Samarai, I.; Albuquerque, I. F. M.; Allekotte, I.; Allen, J.; Allison, P.; Almela, A.; Alvarez Castillo, J.; Alvarez-Muñiz, J.; Alves Batista, R.; Ambrosio, M.; Aminaei, A.; Anchordoqui, L.; Andringa, S.; Aramo, C.; Aranda, V. M.; Arqueros, F.; Asorey, H.; Assis, P.; Aublin, J.; Ave, M.; Avenier, M.; Avila, G.; Badescu, A. M.; Barber, K. B.; Bäuml, J.; Baus, C.; Beatty, J. J.; Becker, K. H.; Bellido, J. A.; Berat, C.; Bertaina, M. E.; Bertou, X.; Biermann, P. L.; Billoir, P.; Blanco, M.; Bleve, C.; Blümer, H.; Boháčová, M.; Boncioli, D.; Bonifazi, C.; Bonino, R.; Borodai, N.; Brack, J.; Brancus, I.; Brogueira, P.; Brown, W. C.; Buchholz, P.; Bueno, A.; Buitink, S.; Buscemi, M.; Caballero-Mora, K. S.; Caccianiga, B.; Caccianiga, L.; Candusso, M.; Caramete, L.; Caruso, R.; Castellina, A.; Cataldi, G.; Cazon, L.; Cester, R.; Chavez, A. G.; Chiavassa, A.; Chinellato, J. A.; Chudoba, J.; Cilmo, M.; Clay, R. W.; Cocciolo, G.; Colalillo, R.; Coleman, A.; Collica, L.; Coluccia, M. R.; Conceição, R.; Contreras, F.; Cooper, M. J.; Cordier, A.; Coutu, S.; Covault, C. E.; Cronin, J.; Curutiu, A.; Dallier, R.; Daniel, B.; Dasso, S.; Daumiller, K.; Dawson, B. R.; de Almeida, R. M.; De Domenico, M.; de Jong, S. J.; de Mello Neto, J. R. T.; De Mitri, I.; de Oliveira, J.; de Souza, V.; del Peral, L.; Deligny, O.; Dembinski, H.; Dhital, N.; Di Giulio, C.; Di Matteo, A.; Diaz, J. C.; Díaz Castro, M. L.; Diogo, F.; Dobrigkeit, C.; Docters, W.; D'Olivo, J. C.; Dorofeev, A.; Dorosti Hasankiadeh, Q.; Dova, M. T.; Ebr, J.; Engel, R.; Erdmann, M.; Erfani, M.; Escobar, C. O.; Espadanal, J.; Etchegoyen, A.; Facal San Luis, P.; Falcke, H.; Fang, K.; Farrar, G.; Fauth, A. C.; Fazzini, N.; Ferguson, A. P.; Fernandes, M.; Fick, B.; Figueira, J. M.; Filevich, A.; Filipčič, A.; Fox, B. D.; Fratu, O.; Fröhlich, U.; Fuchs, B.; Fujii, T.; Gaior, R.; García, B.; Garcia Roca, S. T.; Garcia-Gamez, D.; Garcia-Pinto, D.; Garilli, G.; Gascon Bravo, A.; Gate, F.; Gemmeke, H.; Ghia, P. L.; Giaccari, U.; Giammarchi, M.; Giller, M.; Glaser, C.; Glass, H.; Gómez Berisso, M.; Gómez Vitale, P. F.; Gonçalves, P.; Gonzalez, J. G.; González, N.; Gookin, B.; Gordon, J.; Gorgi, A.; Gorham, P.; Gouffon, P.; Grebe, S.; Griffith, N.; Grillo, A. F.; Grubb, T. D.; Guardincerri, Y.; Guarino, F.; Guedes, G. P.; Hampel, M. R.; Hansen, P.; Harari, D.; Harrison, T. A.; Hartmann, S.; Harton, J. L.; Haungs, A.; Hebbeker, T.; Heck, D.; Heimann, P.; Herve, A. E.; Hill, G. C.; Hojvat, C.; Hollon, N.; Holt, E.; Homola, P.; Hörandel, J. R.; Horvath, P.; Hrabovský, M.; Huber, D.; Huege, T.; Insolia, A.; Isar, P. G.; Islo, K.; Jandt, I.; Jansen, S.; Jarne, C.; Josebachuili, M.; Kääpä, A.; Kambeitz, O.; Kampert, K. H.; Kasper, P.; Katkov, I.; Kégl, B.; Keilhauer, B.; Keivani, A.; Kemp, E.; Kieckhafer, R. M.; Klages, H. O.; Kleifges, M.; Kleinfeller, J.; Krause, R.; Krohm, N.; Krömer, O.; Kruppke-Hansen, D.; Kuempel, D.; Kunka, N.; LaHurd, D.; Latronico, L.; Lauer, R.; Lauscher, M.; Lautridou, P.; Le Coz, S.; Leão, M. S. A. B.; Lebrun, D.; Lebrun, P.; Leigui de Oliveira, M. A.; Letessier-Selvon, A.; Lhenry-Yvon, I.; Link, K.; López, R.; Louedec, K.; Lozano Bahilo, J.; Lu, L.; Lucero, A.; Ludwig, M.; Malacari, M.; Maldera, S.; Mallamaci, M.; Maller, J.; Mandat, D.; Mantsch, P.; Mariazzi, A. G.; Marin, V.; Mariş, I. C.; Marsella, G.; Martello, D.; Martin, L.; Martinez, H.; Martínez Bravo, O.; Martraire, D.; Masías Meza, J. J.; Mathes, H. J.; Mathys, S.; Matthews, J. J.; Matthews, A. J.; Matthiae, G.; Maurel, D.; Maurizio, D.; Mayotte, E.; Mazur, P. O.; Medina, C.; Medina-Tanco, G.; Melissas, M.; Melo, D.; Menshikov, A.; Messina, S.; Meyhandan, R.; Mićanović, S.; Micheletti, M. I.; Middendorf, L.; Minaya, I. A.; Miramonti, L.; Mitrica, B.; Molina-Bueno, L.; Mollerach, S.; Monasor, M.; Monnier Ragaigne, D.; Montanet, F.; Morello, C.; Mostafá, M.; Moura, C. A.; Muller, M. A.; Müller, G.; Münchmeyer, M.; Mussa, R.; Navarra, G.; Navas, S.; Necesal, P.; Nellen, L.; Nelles, A.; Neuser, J.; Newton, D.; Niechciol, M.; Niemietz, L.; Niggemann, T.; Nitz, D.; Nosek, D.; Novotny, V.; Nožka, L.; Ochilo, L.; Olinto, A.; Oliveira, M.; Olmos-Gilbaja, V. M.; Pacheco, N.; Pakk Selmi-Dei, D.; Palatka, M.; Pallotta, J.; Palmieri, N.; Papenbreer, P.; Parente, G.; Parra, A.; Paul, T.; Pech, M.; Pekala, J.; Pelayo, R.; Pepe, I. M.; Perrone, L.; Petermann, E.; Peters, C.; Petrera, S.; Petrov, Y.; Phuntsok, J.; Piegaia, R.; Pierog, T.; Pieroni, P.; Pimenta, M.; Pirronello, V.; Platino, M.; Plum, M.; Porcelli, A.; Porowski, C.; Prado, R. R.; Privitera, P.; Prouza, M.; Purrello, V.; Quel, E. J.; Querchfeld, S.; Quinn, S.; Rautenberg, J.; Ravel, O.; Ravignani, D.; Revenu, B.; Ridky, J.; Riggi, S.; Risse, M.; Ristori, P.; Rizi, V.; Roberts, J.; Rodrigues de Carvalho, W.; Rodriguez Fernandez, G.; Rodriguez Rojo, J.; Rodríguez-Frías, M. D.; Ros, G.; Rosado, J.; Rossler, T.; Roth, M.; Roulet, E.; Rovero, A. C.; Saffi, S. J.; Saftoiu, A.; Salamida, F.; Salazar, H.; Saleh, A.; Salesa Greus, F.; Salina, G.; Sánchez, F.; Sanchez-Lucas, P.; Santo, C. E.; Santos, E.; Santos, E. M.; Sarazin, F.; Sarkar, B.; Sarmento, R.; Sato, R.; Scharf, N.; Scherini, V.; Schieler, H.; Schiffer, P.; Scholten, O.; Schoorlemmer, H.; Schovánek, P.; Schröder, F. G.; Schulz, A.; Schulz, J.; Schumacher, J.; Sciutto, S. J.; Segreto, A.; Settimo, M.; Shadkam, A.; Shellard, R. C.; Sidelnik, I.; Sigl, G.; Sima, O.; Śmiałkowski, A.; Šmída, R.; Snow, G. R.; Sommers, P.; Sorokin, J.; Squartini, R.; Srivastava, Y. N.; Stanič, S.; Stapleton, J.; Stasielak, J.; Stephan, M.; Stutz, A.; Suarez, F.; Suomijärvi, T.; Supanitsky, A. D.; Sutherland, M. S.; Swain, J.; Szadkowski, Z.; Szuba, M.; Taborda, O. A.; Tapia, A.; Tartare, M.; Tepe, A.; Theodoro, V. M.; Timmermans, C.; Todero Peixoto, C. J.; Toma, G.; Tomankova, L.; Tomé, B.; Tonachini, A.; Torralba Elipe, G.; Torres Machado, D.; Travnicek, P.; Trovato, E.; Ulrich, R.; Unger, M.; Urban, M.; Valdés Galicia, J. F.; Valiño, I.; Valore, L.; van Aar, G.; van den Berg, A. M.; van Velzen, S.; van Vliet, A.; Varela, E.; Vargas Cárdenas, B.; Varner, G.; Vázquez, J. R.; Vázquez, R. A.; Veberič, D.; Verzi, V.; Vicha, J.; Videla, M.; Villaseñor, L.; Vlcek, B.; Vorobiov, S.; Wahlberg, H.; Wainberg, O.; Walz, D.; Watson, A. A.; Weber, M.; Weidenhaupt, K.; Weindl, A.; Werner, F.; Widom, A.; Wiencke, L.; Wilczyńska, B.; Wilczyński, H.; Will, M.; Williams, C.; Winchen, T.; Wittkowski, D.; Wundheiler, B.; Wykes, S.; Yamamoto, T.; Yapici, T.; Younk, P.; Yuan, G.; Yushkov, A.; Zamorano, B.; Zas, E.; Zavrtanik, D.; Zavrtanik, M.; Zaw, I.; Zepeda, A.; Zhou, J.; Zhu, Y.; Zimbres Silva, M.; Ziolkowski, M.; Zuccarello, F.; Pierre Auger Collaboration, [No Value
2015-01-01
We present the first hybrid measurement of the average muon number in air showers at ultrahigh energies, initiated by cosmic rays with zenith angles between 62° and 80°. The measurement is based on 174 hybrid events recorded simultaneously with the surface detector array and the fluorescence
Maccormack, R. W.
1978-01-01
The calculation of flow fields past aircraft configuration at flight Reynolds numbers is considered. Progress in devising accurate and efficient numerical methods, in understanding and modeling the physics of turbulence, and in developing reliable and powerful computer hardware is discussed. Emphasis is placed on efficient solutions to the Navier-Stokes equations.
A two-dimensional, TVD numerical scheme for inviscid, high Mach number flows in chemical equilibrium
Eberhardt, S.; Palmer, G.
1986-01-01
A new algorithm has been developed for hypervelocity flows in chemical equilibrium. Solutions have been achieved for Mach numbers up to 15 with no adverse effect on convergence. Two methods of coupling an equilibrium chemistry package have been tested, with the simpler method proving to be more robust. Improvements in boundary conditions are still required for a production-quality code.
Sammy, Mo
2010-01-01
Active flow control is often used to manipulate flow instabilities to achieve a desired goal (e.g. prevent separation, enhance mixing, reduce noise, etc.). Instability frequencies normally scale with flow velocity scale and inversely with flow length scale (U/l). In a laboratory setting for such flow experiments, U is high, but l is low, resulting in high instability frequency. In addition, high momentum and high background noise & turbulence in the flow necessitate high amplitude actuation. Developing a high amplitude and high frequency actuator is a major challenge. Ironically, these requirements ease up in application (but other issues arise).
A Fast, High Quality, and Reproducible Parallel Lagged-Fibonacci Pseudorandom Number Generator
Mascagni, Michael; Cuccaro, Steven A.; Pryor, Daniel V.; Robinson, M. L.
1995-07-01
We study the suitability of the additive lagged-Fibonacci pseudo-random number generator for parallel computation. This generator has relatively short period with respect to the size of its seed. However, the short period is more than made up for with the huge number of full-period cycles it contains. These different full period cycles are called equivalence classes. We show how to enumerate the equivalence classes and how to compute seeds to select a given equivalence class, In addition, we present some theoretical measures of quality for this generator when used in parallel. Next, we conjecture on the size of these measures of quality for this generator. Extensive empirical evidence supports this conjecture. In addition, a probabilistic interpretation of these measures leads to another conjecture similarly supported by empirical evidence. Finally we give an explicit parallelization suitable for a fully reproducible asynchronous MIMD implementation.
Seeking the purported magic number N= 32 with high-precision mass spectrometry
Schweikhard, L C; Herfurth, F; Boehm, C; Manea, V; Blaum, K; Beck, D; Kowalska, M; Kreim, K D; Stanja, J; Audi, G; Rosenbusch, M; Wienholtz, F; Litvinov, Y
Accounting for the appearance of new magic numbers represents an exacting test for nuclear models. Binding energies offer a clear signature for the presence (or disappearance) of shell closures. To determine the strength of the purported N = 32 shell closure, we propose using the Penning-trap spectrometer ISOLTRAP for mass measurements of N = 34 isotones $^{58}$Cr (Z = 24), $^{55}$Sc (Z = 21) and $^{54}$Ca (Z = 20), as well as the N = 32 isotones $^{53}$Sc and $^{52}$Ca. We also propose measuring the mass of $^{60}$Cr to test the shell model prediction of a new magic number at N = 34. In addition to the Penning-trap system at ISOLTRAP, we intend to use the newly commissioned multi-reflection time-of-flight mass separator, which enables direct mass measurements on nuclei with half-lives below 50 ms.
Seeking the purported magic number N= 32 with high-precision mass spectrometry
Kreim, S; Blaum, K; Bohm, Ch; Borgmann, Ch; Breitenfeldt, M; Cakirli, R B; Herfurth, F; Kowalska, M; Litvinov, Y; Lunney, D; Manea, V; Naimi, S; Neidherr, D; Rosenbusch, M; Schweikhard, L; Stanja, J; Stora, Th; Wienholtz, F; Wolf, R N; Zuber, K
2011-01-01
Accounting for the appearance of new magic numbers represents an exacting test for nuclear models. Binding energies o er a clear signature for the presence (or dis- appearance) of shell closures. To determine the strength of the purported N = 32 shell closure, we propose using the Penning-trap spectrometer ISOLTRAP for mass measure- ments of N = 34 isotones 58 Cr ( Z = 24), 55 Sc ( Z = 21) and 54 Ca ( Z = 20), as well as the N = 32 isotones 53 Sc and 52 Ca. We also propose measuring the mass of 60 Cr to test the shell model prediction of a new magic number at N = 34. In addition to the Penning-trap system at ISOLTRAP, we intend to use the newly commissioned multi-re ection time-of- ight mass separator, which enables direct mass measurements on nuclei with half-lives below 50 ms.
2016-03-24
multiple Damkohler or Karlovitz numbers to account for auto - ignition and other types of chemistry, (d)… For example, residence time is important since...First, the rapid compression of reactants within a shock tube or an HCCI engine is known to rapidly elevate the temperature of the reactants above...the ignition temperature, causing reactions to become distributed in space [4]. Alden et al. reported broad CH zones within an HCCI engine experiment
Large scale Direct Numerical Simulation of premixed turbulent jet flames at high Reynolds number
Attili, Antonio; Luca, Stefano; Lo Schiavo, Ermanno; Bisetti, Fabrizio; Creta, Francesco
2016-11-01
A set of direct numerical simulations of turbulent premixed jet flames at different Reynolds and Karlovitz numbers is presented. The simulations feature finite rate chemistry with 16 species and 73 reactions and up to 22 Billion grid points. The jet consists of a methane/air mixture with equivalence ratio ϕ = 0 . 7 and temperature varying between 500 and 800 K. The temperature and species concentrations in the coflow correspond to the equilibrium state of the burnt mixture. All the simulations are performed at 4 atm. The flame length, normalized by the jet width, decreases significantly as the Reynolds number increases. This is consistent with an increase of the turbulent flame speed due to the increased integral scale of turbulence. This behavior is typical of flames in the thin-reaction zone regime, which are affected by turbulent transport in the preheat layer. Fractal dimension and topology of the flame surface, statistics of temperature gradients, and flame structure are investigated and the dependence of these quantities on the Reynolds number is assessed.
Self-similarity in high Atwood number Rayleigh-Taylor experiments
Mikhaeil, Mark; Suchandra, Prasoon; Pathikonda, Gokul; Ranjan, Devesh
2017-11-01
Self-similarity is a critical concept in turbulent and mixing flows. In the Rayleigh-Taylor instability, theory and simulations have shown that the flow exhibits properties of self-similarity as the mixing Reynolds number exceeds 20000 and the flow enters the turbulent regime. Here, we present results from the first large Atwood number (0.7) Rayleigh-Taylor experimental campaign for mixing Reynolds number beyond 20000 in an effort to characterize the self-similar nature of the instability. Experiments are performed in a statistically steady gas tunnel facility, allowing for the evaluation of turbulence statistics. A visualization diagnostic is used to study the evolution of the mixing width as the instability grows. This allows for computation of the instability growth rate. For the first time in such a facility, stereoscopic particle image velocimetry is used to resolve three-component velocity information in a plane. Velocity means, fluctuations, and correlations are considered as well as their appropriate scaling. Probability density functions of velocity fields, energy spectra, and higher-order statistics are also presented. The energy budget of the flow is described, including the ratio of the kinetic energy to the released potential energy. This work was supported by the DOE-NNSA SSAA Grant DE-NA0002922.
Mejía-Benítez, María A; Bonnefond, Amélie; Yengo, Loïc; Huyvaert, Marlène; Dechaume, Aurélie; Peralta-Romero, Jesús; Klünder-Klünder, Miguel; García Mena, Jaime; El-Sayed Moustafa, Julia S; Falchi, Mario; Cruz, Miguel; Froguel, Philippe
2015-02-01
Childhood obesity is a major public health problem in Mexico, affecting one in every three children. Genome-wide association studies identified genetic variants associated with childhood obesity, but a large missing heritability remains to be elucidated. We have recently shown a strong association between a highly polymorphic copy number variant encompassing the salivary amylase gene (AMY1 also known as AMY1A) and obesity in European and Asian adults. In the present study, we aimed to evaluate the association between AMY1 copy number and obesity in Mexican children. We evaluated the number of AMY1 copies in 597 Mexican children (293 obese children and 304 normal weight controls) through highly sensitive digital PCR. The effect of AMY1 copy number on obesity status was assessed using a logistic regression model adjusted for age and sex. We identified a marked effect of AMY1 copy number on reduced risk of obesity (OR per estimated copy 0.84, with the number of copies ranging from one to 16 in this population; p = 4.25 × 10(-6)). The global association between AMY1 copy number and reduced risk of obesity seemed to be mostly driven by the contribution of the highest AMY1 copy number. Strikingly, all children with >10 AMY1 copies were normal weight controls. Salivary amylase initiates the digestion of dietary starch, which is highly consumed in Mexico. Our current study suggests putative benefits of high number of AMY1 copies (and related production of salivary amylase) on energy metabolism in Mexican children.
Epstein, Ann S.
This document is comprised of 10 High/Scope fact sheets for parents, detailing the history of the High/Scope educational approach and describing its educational practice and curriculum. The major topic for each four-page fact sheet follows: (1) educational approach, including goals for young children and features of the High/Scope approach to…
Number projected statistics and the pairing correlations at high excitation energies
Esebbag, C.; Egido, J.L.
1993-01-01
We analyze the use of particle-number projected statistics (PNPS) as an effective way to include the quantum and statistical fluctuations, associated with the pairing degree of freedom, left out in finite-temperature mean-field theories. As a numerical application the exact-soluble degenerate model is worked out. In particular, we find that the sharp temperature-induced superfluid-normal phase transition, predicted in the mean-field approximations, is washed out in the PNPS. Some approximations as well as the Landau prescription to include statistical fluctuations are also discussed. We find that the Landau prescription provides a reasonable approximation to the PNPS. (orig.)
Dogan, Eda; Hearst, R Jason; Ganapathisubramani, Bharathram
2017-03-13
A turbulent boundary layer subjected to free-stream turbulence is investigated in order to ascertain the scale interactions that dominate the near-wall region. The results are discussed in relation to a canonical high Reynolds number turbulent boundary layer because previous studies have reported considerable similarities between these two flows. Measurements were acquired simultaneously from four hot wires mounted to a rake which was traversed through the boundary layer. Particular focus is given to two main features of both canonical high Reynolds number boundary layers and boundary layers subjected to free-stream turbulence: (i) the footprint of the large scales in the logarithmic region on the near-wall small scales, specifically the modulating interaction between these scales, and (ii) the phase difference in amplitude modulation. The potential for a turbulent boundary layer subjected to free-stream turbulence to 'simulate' high Reynolds number wall-turbulence interactions is discussed. The results of this study have encouraging implications for future investigations of the fundamental scale interactions that take place in high Reynolds number flows as it demonstrates that these can be achieved at typical laboratory scales.This article is part of the themed issue 'Toward the development of high-fidelity models of wall turbulence at large Reynolds number'. © 2017 The Author(s).
Muons in air showers at the Pierre Auger Observatory: Mean number in highly inclined events
Aab, A.; Abreu, P.; Aglietta, M.; Ahn, E. J.; Al Samarai, I.; Albuquerque, I. F. M.; Allekotte, I.; Allen, J.; Allison, P.; Almela, A.; Alvarez Castillo, J.; Alvarez-Muñiz, J.; Alves Batista, R.; Ambrosio, M.; Aminaei, A.; Anchordoqui, L.; Andringa, S.; Aramo, C.; Aranda, V. M.; Arqueros, F.; Asorey, H.; Assis, P.; Aublin, J.; Ave, M.; Avenier, M.; Avila, G.; Badescu, A. M.; Barber, K. B.; Bäuml, J.; Baus, C.; Beatty, J. J.; Becker, K. H.; Bellido, J. A.; Berat, C.; Bertaina, M. E.; Bertou, X.; Biermann, P. L.; Billoir, P.; Blanco, M.; Bleve, C.; Blümer, H.; Boháčová, M.; Boncioli, D.; Bonifazi, C.; Bonino, R.; Borodai, N.; Brack, J.; Brancus, I.; Brogueira, P.; Brown, W. C.; Buchholz, P.; Bueno, A.; Buitink, S.; Buscemi, M.; Caballero-Mora, K. S.; Caccianiga, B.; Caccianiga, L.; Candusso, M.; Caramete, L.; Caruso, R.; Castellina, A.; Cataldi, G.; Cazon, L.; Cester, R.; Chavez, A. G.; Chiavassa, A.; Chinellato, J. A.; Chudoba, J.; Cilmo, M.; Clay, R. W.; Cocciolo, G.; Colalillo, R.; Coleman, A.; Collica, L.; Coluccia, M. R.; Conceição, R.; Contreras, F.; Cooper, M. J.; Cordier, A.; Coutu, S.; Covault, C. E.; Cronin, J.; Curutiu, A.; Dallier, R.; Daniel, B.; Dasso, S.; Daumiller, K.; Dawson, B. R.; de Almeida, R. M.; De Domenico, M.; de Jong, S. J.; de Mello Neto, J. R. T.; De Mitri, I.; de Oliveira, J.; de Souza, V.; del Peral, L.; Deligny, O.; Dembinski, H.; Dhital, N.; Di Giulio, C.; Di Matteo, A.; Diaz, J. C.; Díaz Castro, M. L.; Diogo, F.; Dobrigkeit, C.; Docters, W.; D'Olivo, J. C.; Dorofeev, A.; Dorosti Hasankiadeh, Q.; Dova, M. T.; Ebr, J.; Engel, R.; Erdmann, M.; Erfani, M.; Escobar, C. O.; Espadanal, J.; Etchegoyen, A.; Facal San Luis, P.; Falcke, H.; Fang, K.; Farrar, G.; Fauth, A. C.; Fazzini, N.; Ferguson, A. P.; Fernandes, M.; Fick, B.; Figueira, J. M.; Filevich, A.; Filipčič, A.; Fox, B. D.; Fratu, O.; Fröhlich, U.; Fuchs, B.; Fujii, T.; Gaior, R.; García, B.; Garcia Roca, S. T.; Garcia-Gamez, D.; Garcia-Pinto, D.; Garilli, G.; Gascon Bravo, A.; Gate, F.; Gemmeke, H.; Ghia, P. L.; Giaccari, U.; Giammarchi, M.; Giller, M.; Glaser, C.; Glass, H.; Gómez Berisso, M.; Gómez Vitale, P. F.; Gonçalves, P.; Gonzalez, J. G.; González, N.; Gookin, B.; Gordon, J.; Gorgi, A.; Gorham, P.; Gouffon, P.; Grebe, S.; Griffith, N.; Grillo, A. F.; Grubb, T. D.; Guardincerri, Y.; Guarino, F.; Guedes, G. P.; Hampel, M. R.; Hansen, P.; Harari, D.; Harrison, T. A.; Hartmann, S.; Harton, J. L.; Haungs, A.; Hebbeker, T.; Heck, D.; Heimann, P.; Herve, A. E.; Hill, G. C.; Hojvat, C.; Hollon, N.; Holt, E.; Homola, P.; Hörandel, J. R.; Horvath, P.; Hrabovský, M.; Huber, D.; Huege, T.; Insolia, A.; Isar, P. G.; Islo, K.; Jandt, I.; Jansen, S.; Jarne, C.; Josebachuili, M.; Kääpä, A.; Kambeitz, O.; Kampert, K. H.; Kasper, P.; Katkov, I.; Kégl, B.; Keilhauer, B.; Keivani, A.; Kemp, E.; Kieckhafer, R. M.; Klages, H. O.; Kleifges, M.; Kleinfeller, J.; Krause, R.; Krohm, N.; Krömer, O.; Kruppke-Hansen, D.; Kuempel, D.; Kunka, N.; LaHurd, D.; Latronico, L.; Lauer, R.; Lauscher, M.; Lautridou, P.; Le Coz, S.; Leão, M. S. A. B.; Lebrun, D.; Lebrun, P.; Leigui de Oliveira, M. A.; Letessier-Selvon, A.; Lhenry-Yvon, I.; Link, K.; López, R.; Louedec, K.; Lozano Bahilo, J.; Lu, L.; Lucero, A.; Ludwig, M.; Malacari, M.; Maldera, S.; Mallamaci, M.; Maller, J.; Mandat, D.; Mantsch, P.; Mariazzi, A. G.; Marin, V.; Mariş, I. C.; Marsella, G.; Martello, D.; Martin, L.; Martinez, H.; Martínez Bravo, O.; Martraire, D.; Masías Meza, J. J.; Mathes, H. J.; Mathys, S.; Matthews, J. J.; Matthews, A. J.; Matthiae, G.; Maurel, D.; Maurizio, D.; Mayotte, E.; Mazur, P. O.; Medina, C.; Medina-Tanco, G.; Melissas, M.; Melo, D.; Menshikov, A.; Messina, S.; Meyhandan, R.; Mićanović, S.; Micheletti, M. I.; Middendorf, L.; Minaya, I. A.; Miramonti, L.; Mitrica, B.; Molina-Bueno, L.; Mollerach, S.; Monasor, M.; Monnier Ragaigne, D.; Montanet, F.; Morello, C.; Mostafá, M.; Moura, C. A.; Muller, M. A.; Müller, G.; Münchmeyer, M.; Mussa, R.; Navarra, G.; Navas, S.; Necesal, P.; Nellen, L.; Nelles, A.; Neuser, J.; Newton, D.; Niechciol, M.; Niemietz, L.; Niggemann, T.; Nitz, D.; Nosek, D.; Novotny, V.; Nožka, L.; Ochilo, L.; Olinto, A.; Oliveira, M.; Olmos-Gilbaja, V. M.; Pacheco, N.; Pakk Selmi-Dei, D.; Palatka, M.; Pallotta, J.; Palmieri, N.; Papenbreer, P.; Parente, G.; Parra, A.; Paul, T.; Pech, M.; Pekala, J.; Pelayo, R.; Pepe, I. M.; Perrone, L.; Petermann, E.; Peters, C.; Petrera, S.; Petrov, Y.; Phuntsok, J.; Piegaia, R.; Pierog, T.; Pieroni, P.; Pimenta, M.; Pirronello, V.; Platino, M.; Plum, M.; Porcelli, A.; Porowski, C.; Prado, R. R.; Privitera, P.; Prouza, M.; Purrello, V.; Quel, E. J.; Querchfeld, S.; Quinn, S.; Rautenberg, J.; Ravel, O.; Ravignani, D.; Revenu, B.; Ridky, J.; Riggi, S.; Risse, M.; Ristori, P.; Rizi, V.; Roberts, J.; Rodrigues de Carvalho, W.; Rodriguez Fernandez, G.; Rodriguez Rojo, J.; Rodríguez-Frías, M. D.; Ros, G.; Rosado, J.; Rossler, T.; Roth, M.; Roulet, E.; Rovero, A. C.; Saffi, S. J.; Saftoiu, A.; Salamida, F.; Salazar, H.; Saleh, A.; Salesa Greus, F.; Salina, G.; Sánchez, F.; Sanchez-Lucas, P.; Santo, C. E.; Santos, E.; Santos, E. M.; Sarazin, F.; Sarkar, B.; Sarmento, R.; Sato, R.; Scharf, N.; Scherini, V.; Schieler, H.; Schiffer, P.; Scholten, O.; Schoorlemmer, H.; Schovánek, P.; Schröder, F. G.; Schulz, A.; Schulz, J.; Schumacher, J.; Sciutto, S. J.; Segreto, A.; Settimo, M.; Shadkam, A.; Shellard, R. C.; Sidelnik, I.; Sigl, G.; Sima, O.; Śmiałkowski, A.; Šmída, R.; Snow, G. R.; Sommers, P.; Sorokin, J.; Squartini, R.; Srivastava, Y. N.; Stanič, S.; Stapleton, J.; Stasielak, J.; Stephan, M.; Stutz, A.; Suarez, F.; Suomijärvi, T.; Supanitsky, A. D.; Sutherland, M. S.; Swain, J.; Szadkowski, Z.; Szuba, M.; Taborda, O. A.; Tapia, A.; Tartare, M.; Tepe, A.; Theodoro, V. M.; Timmermans, C.; Todero Peixoto, C. J.; Toma, G.; Tomankova, L.; Tomé, B.; Tonachini, A.; Torralba Elipe, G.; Torres Machado, D.; Travnicek, P.; Trovato, E.; Ulrich, R.; Unger, M.; Urban, M.; Valdés Galicia, J. F.; Valiño, I.; Valore, L.; van Aar, G.; van den Berg, A. M.; van Velzen, S.; van Vliet, A.; Varela, E.; Vargas Cárdenas, B.; Varner, G.; Vázquez, J. R.; Vázquez, R. A.; Veberič, D.; Verzi, V.; Vicha, J.; Videla, M.; Villaseñor, L.; Vlcek, B.; Vorobiov, S.; Wahlberg, H.; Wainberg, O.; Walz, D.; Watson, A. A.; Weber, M.; Weidenhaupt, K.; Weindl, A.; Werner, F.; Widom, A.; Wiencke, L.; Wilczyńska, B.; Wilczyński, H.; Will, M.; Williams, C.; Winchen, T.; Wittkowski, D.; Wundheiler, B.; Wykes, S.; Yamamoto, T.; Yapici, T.; Younk, P.; Yuan, G.; Yushkov, A.; Zamorano, B.; Zas, E.; Zavrtanik, D.; Zavrtanik, M.; Zaw, I.; Zepeda, A.; Zhou, J.; Zhu, Y.; Zimbres Silva, M.; Ziolkowski, M.; Zuccarello, F.; Pierre Auger Collaboration
2015-02-01
We present the first hybrid measurement of the average muon number in air showers at ultrahigh energies, initiated by cosmic rays with zenith angles between 62° and 80°. The measurement is based on 174 hybrid events recorded simultaneously with the surface detector array and the fluorescence detector of the Pierre Auger Observatory. The muon number for each shower is derived by scaling a simulated reference profile of the lateral muon density distribution at the ground until it fits the data. A 1019 eV shower with a zenith angle of 67°, which arrives at the surface detector array at an altitude of 1450 m above sea level, contains on average (2.68 ±0.04 ±0.48 (sys))×107 muons with energies larger than 0.3 GeV. The logarithmic gain d ln Nμ/d ln E of muons with increasing energy between 4 ×1018 eV and 5 ×1019 eV is measured to be (1.029 ±0.024 ±0.030 (sys)) .
Butterfield, J.M.
1981-01-01
A system is considered where a number of pumps operate in parallel. Normally, all pumps operate, driven by main motors fed from the grid. Each pump has a pony motor fed from an individual battery supply. Each pony motor is normally running, but not engaged to the pump shaft. On demand, e.g. failure of grid supplies, each pony motor is designed to clutch-in automatically when the pump speed falls to a specified value. The probability of all the pony motors failing to clutch-in on demand must be demonstrated with 95% confidence to be less than 10 -8 per demand. This assessment considers how the required reliability of pony motor drives might be demonstrated in practice and the implications on choice of the number of pumps at the design stage. The assessment recognises that not only must the system prove to be extremely reliable, but that demonstration that reliability is adequate must be done during plant commissioning, with practical limits on the amount of testing performed. It is concluded that a minimum of eight pony motors should be provided, eight pumps each with one pony motor (preferred) or five pumps each with two independent pony motors. A minimum of two diverse pony motor systems should be provided. (author)
Yeung, P. K.; Sreenivasan, K. R.
2014-01-01
In a recent direct numerical simulation (DNS) study [P. K. Yeung and K. R. Sreenivasan, "Spectrum of passive scalars of high molecular diffusivity in turbulent mixing," J. Fluid Mech. 716, R14 (2013)] with Schmidt number as low as 1/2048, we verified the essential physical content of the theory of Batchelor, Howells, and Townsend ["Small-scale variation of convected quantities like temperature in turbulent fluid. 2. The case of large conductivity," J. Fluid Mech. 5, 134 (1959)] for turbulent passive scalar fields with very strong diffusivity, decaying in the absence of any production mechanism. In particular, we confirmed the existence of the -17/3 power of the scalar spectral density in the so-called inertial-diffusive range. In the present paper, we consider the DNS of the same problem, but in the presence of a uniform mean gradient, which leads to the production of scalar fluctuations at (primarily) the large scales. For the parameters of the simulations, the presence of the mean gradient alters the physics of mixing fundamentally at low Peclet numbers. While the spectrum still follows a -17/3 power law in the inertial-diffusive range, the pre-factor is non-universal and depends on the magnitude of the mean scalar gradient. Spectral transfer is greatly reduced in comparison with those for moderately and weakly diffusive scalars, leading to several distinctive features such as the absence of dissipative anomaly and a new balance of terms in the spectral transfer equation for the scalar variance, differing from the case of zero gradient. We use the DNS results to present an alternative explanation for the observed scaling behavior, and discuss a few spectral characteristics in detail.
Tests of Full-Scale Helicopter Rotors at High Advancing Tip Mach Numbers and Advance Ratios
Biggers, James C.; McCloud, John L., III; Stroub, Robert H.
2015-01-01
As a continuation of the studies of reference 1, three full-scale helicopter rotors have been tested in the Ames Research Center 40- by SO-foot wind tunnel. All three of them were two-bladed, teetering rotors. One of the rotors incorporated the NACA 0012 airfoil section over the entire length of the blade. This rotor was tested at advance ratios up to 1.05. Both of the other rotors were tapered in thickness and incorporated leading-edge camber over the outer 20 percent of the blade radius. The larger of these rotors was tested at advancing tip Mach numbers up to 1.02. Data were obtained for a wide range of lift and propulsive force, and are presented without discussion.
Spectroscopic studies of a high Mach-number rotating plasma flow
Ando, Akira; Ashino, Masashi; Sagi, Yukiko; Inutake, Masaaki; Hattori, Kunihiko; Yoshinuma, Mikirou; Imasaki, Atsushi; Tobari, Hiroyuki; Yagai, Tsuyoshi
2001-01-01
Characteristics of an axially-magnetized rotating plasma are investigated by spectroscopy in the HITOP device of Tohoku University. A He plasma flows our axially and rotates azimuthally near the muzzle region of the MPD arcjet. Flow and rotational velocities and temperature of He ions and atoms are measured by Doppler shift and broadening of the HeII (γ=468.58 nm) and HeI (γ=587.56 nm) lines. Rotational velocity increases with the increase of axially-applied magnetic field strength and discharge current. As discharge current increases and mass flow rate decreases, the plasma flow velocity increases and T i increases. Ion acoustic Mach number of the plasma flow also increases, but tends to saturate at near 1. Radial profile of space potential is calculated from the obtained rotational velocity. The potential profile in the core region is parabolic corresponding to the observed rigid-body rotation of the core plasma. (author)
Spectroscopic studies of a high Mach-number rotating plasma flow
Ando, Akira; Ashino, Masashi; Sagi, Yukiko; Inutake, Masaaki; Hattori, Kunihiko; Yoshinuma, Mikirou; Imasaki, Atsushi; Tobari, Hiroyuki; Yagai, Tsuyoshi [Tohoku Univ., Dept. of Electrical Engineering, Sendai, Miyagi (Japan)
2001-07-01
Characteristics of an axially-magnetized rotating plasma are investigated by spectroscopy in the HITOP device of Tohoku University. A He plasma flows our axially and rotates azimuthally near the muzzle region of the MPD arcjet. Flow and rotational velocities and temperature of He ions and atoms are measured by Doppler shift and broadening of the HeII ({gamma}=468.58 nm) and HeI ({gamma}=587.56 nm) lines. Rotational velocity increases with the increase of axially-applied magnetic field strength and discharge current. As discharge current increases and mass flow rate decreases, the plasma flow velocity increases and T{sub i} increases. Ion acoustic Mach number of the plasma flow also increases, but tends to saturate at near 1. Radial profile of space potential is calculated from the obtained rotational velocity. The potential profile in the core region is parabolic corresponding to the observed rigid-body rotation of the core plasma. (author)
High-Speed Device-Independent Quantum Random Number Generation without a Detection Loophole
Liu, Yang; Yuan, Xiao; Li, Ming-Han; Zhang, Weijun; Zhao, Qi; Zhong, Jiaqiang; Cao, Yuan; Li, Yu-Huai; Chen, Luo-Kan; Li, Hao; Peng, Tianyi; Chen, Yu-Ao; Peng, Cheng-Zhi; Shi, Sheng-Cai; Wang, Zhen; You, Lixing; Ma, Xiongfeng; Fan, Jingyun; Zhang, Qiang; Pan, Jian-Wei
2018-01-01
Quantum mechanics provides the means of generating genuine randomness that is impossible with deterministic classical processes. Remarkably, the unpredictability of randomness can be certified in a manner that is independent of implementation devices. Here, we present an experimental study of device-independent quantum random number generation based on a detection-loophole-free Bell test with entangled photons. In the randomness analysis, without the independent identical distribution assumption, we consider the worst case scenario that the adversary launches the most powerful attacks against the quantum adversary. After considering statistical fluctuations and applying an 80 Gb ×45.6 Mb Toeplitz matrix hashing, we achieve a final random bit rate of 114 bits /s , with a failure probability less than 10-5. This marks a critical step towards realistic applications in cryptography and fundamental physics tests.
Spyropoulos, Evangelos T.; Holmes, Bayard S.
1997-01-01
The dynamic subgrid-scale model is employed in large-eddy simulations of flow over a cylinder at a Reynolds number, based on the diameter of the cylinder, of 90,000. The Centric SPECTRUM(trademark) finite element solver is used for the analysis. The far field sound pressure is calculated from Lighthill-Curle's equation using the computed fluctuating pressure at the surface of the cylinder. The sound pressure level at a location 35 diameters away from the cylinder and at an angle of 90 deg with respect to the wake's downstream axis was found to have a peak value of approximately 110 db. Slightly smaller peak values were predicted at the 60 deg and 120 deg locations. A grid refinement study suggests that the dynamic model demands mesh refinement beyond that used here.
Pereira, Luiz Antonio Alcantara [Federal University of Itajuba (UNIFEI), MG (Brazil). Inst. of Mechanical Engineering], E-mail: luizantp@unifei.edu.br; Hirata, Miguel Hiroo [State University of Rio de Janeiro (FAT/UERJ), Resende, RJ (Brazil). Fac. de Tecnologia], E-mail: hirata@fat.uerj.br
2010-07-01
Understanding vortex induced vibrations is of great importance in the design of a variety of offshore engineering structures, nuclear plant components and cylindrical elements in tube-bank heat exchangers, for example. If a body is placed in a flow, it experiences alternating lift and drag forces caused by the asymmetric formation of vortices, which can cause a structure to vibrate. One of the most interesting features of this flow is the phenomenon of lock-in which is observed when the vortex shedding frequency is close to the body oscillation frequency. This paper presents the results of numerical experiments on vortex shedding from a circular cylinder vibrating in-line or transversely with an incident uniform flow at Reynolds number of 1.0 x 10{sup 5}. The frequencies of the lift and drag coefficients are compared with the body motion frequency when the frequency ratio is about unity. (author)
Theory of viscous transonic flow over airfoils at high Reynolds number
Melnik, R. E.; Chow, R.; Mead, H. R.
1977-01-01
This paper considers viscous flows with unseparated turbulent boundary layers over two-dimensional airfoils at transonic speeds. Conventional theoretical methods are based on boundary layer formulations which do not account for the effect of the curved wake and static pressure variations across the boundary layer in the trailing edge region. In this investigation an extended viscous theory is developed that accounts for both effects. The theory is based on a rational analysis of the strong turbulent interaction at airfoil trailing edges. The method of matched asymptotic expansions is employed to develop formal series solutions of the full Reynolds equations in the limit of Reynolds numbers tending to infinity. Procedures are developed for combining the local trailing edge solution with numerical methods for solving the full potential flow and boundary layer equations. Theoretical results indicate that conventional boundary layer methods account for only about 50% of the viscous effect on lift, the remaining contribution arising from wake curvature and normal pressure gradient effects.
Pulsatile turbulent flow through pipe bends at high Dean and Womersley numbers
Kalpakli, Athanasia; Örlü, Ramis; Tillmark, Nils; Alfredsson, P. Henrik
2011-12-01
Turbulent pulsatile flows through pipe bends are prevalent in internal combustion engine components which consist of bent pipe sections and branching conduits. Nonetheless, most of the studies related to pulsatile flows in pipe bends focus on incompressible, low Womersley and low Dean number flows, primarily because they aim in modeling blood flow, while internal combustion engine related flows have mainly been addressed in terms of integral quantities and consist of single point measurements. The present study aims at bridging the gap between these two fields by means of time-resolved stereoscopic particle image velocimetry measurements in a pipe bend with conditions that are close to those encountered in exhaust manifolds. The time/phase-resolved three-dimensional cross-sectional flow-field 3 pipe diameters downstream the pipe bend is captured and the interplay between different secondary motions throughout a pulse cycle is discussed.
Pulsatile turbulent flow through pipe bends at high Dean and Womersley numbers
Kalpakli, Athanasia; Örlü, Ramis; Tillmark, Nils; Alfredsson, P Henrik
2011-01-01
Turbulent pulsatile flows through pipe bends are prevalent in internal combustion engine components which consist of bent pipe sections and branching conduits. Nonetheless, most of the studies related to pulsatile flows in pipe bends focus on incompressible, low Womersley and low Dean number flows, primarily because they aim in modeling blood flow, while internal combustion engine related flows have mainly been addressed in terms of integral quantities and consist of single point measurements. The present study aims at bridging the gap between these two fields by means of time-resolved stereoscopic particle image velocimetry measurements in a pipe bend with conditions that are close to those encountered in exhaust manifolds. The time/phase-resolved three-dimensional cross-sectional flow-field 3 pipe diameters downstream the pipe bend is captured and the interplay between different secondary motions throughout a pulse cycle is discussed.
S.M. Sitompul
2015-02-01
Full Text Available Field studies were conducted in two years using 638 F2 and 1185 F3 lines of selected 16 F1 and 15 F2 parent lines (³80 pods plant-1 to evaluate pod number and CO2 exchange rate (CER as selection criteria. Pod and seed number, and seed weight of individual lines were observed during harvesting time, and CER of randomly selected 32 F2 and 30 F3 lines was measured at initial seed filling stage. The selection of F2 lines based on pod number to generate F3 lines increased the average of seed yield by 39%, and pod number by 77% in F3 lines compared with F2 lines. A close relationships was found between seed weight and pod or seed number per plant. Net CER responded sensitively to a reduction of light in a short-term and showed 78% of F2 lines and all F3 lines with maximum CER (Pmax³20 mmolCO2.m-2.s-1. The ratio of pod number per plant and Pmax varied between lines and were used to group lines resulting in close relationships between Pmax and pod number. It is concluded that the use of pod number and CER (Pmax as selection criteria offers an alternative approach in soybean breeding for high yield.
Matsumoto, Yosuke [Department of Physics, Chiba University, Yayoi-cho 1-33, Inage-ku, Chiba 263-8522 (Japan); Amano, Takanobu; Hoshino, Masahiro, E-mail: ymatumot@astro.s.chiba-u.ac.jp [Department of Earth and Planetary Science, University of Tokyo, Hongo 1-33, Bunkyo-ku, Tokyo 113-0033 (Japan)
2012-08-20
Electron accelerations at high Mach number collisionless shocks are investigated by means of two-dimensional electromagnetic particle-in-cell simulations with various Alfven Mach numbers, ion-to-electron mass ratios, and the upstream electron {beta}{sub e} (the ratio of the thermal pressure to the magnetic pressure). We find electrons are effectively accelerated at a super-high Mach number shock (M{sub A} {approx} 30) with a mass ratio of M/m = 100 and {beta}{sub e} = 0.5. The electron shock surfing acceleration is an effective mechanism for accelerating the particles toward the relativistic regime even in two dimensions with a large mass ratio. Buneman instability excited at the leading edge of the foot in the super-high Mach number shock results in a coherent electrostatic potential structure. While multi-dimensionality allows the electrons to escape from the trapping region, they can interact with the strong electrostatic field several times. Simulation runs in various parameter regimes indicate that the electron shock surfing acceleration is an effective mechanism for producing relativistic particles in extremely high Mach number shocks in supernova remnants, provided that the upstream electron temperature is reasonably low.
Naguib, Ahmed
2003-01-01
.... Moreover, analysis of typical wall-pressure spectra beneath high- and low-Reynolds-number, boundary layers in light of these limits underlines the potential advantage of the new sensor in resolving...
Sun, Z.; Schubert, G.
1995-01-01
In this study, we carry out numerical simulations of thermal convection in a rapidly rotating spherical fluid shell at high Taylor number Ta and Rayleigh number R with a nonlinear, three-dimensional, time-dependent, spectral-transform code. The parameters used in the simulations are chosen to be in a range which allows us to study two different types of convection, i.e., single column and multi-layered types, and the transition between them. Numerical solutions feature highly time-dependent north--south open columnar convective cells. The cells occur irregularly in longitude, are quasi-layered in cylindrical radius, and maintain alternating bands of mean zonal flow. The complex convective structure and the banded mean zonal flow are results of the high Taylor and Rayleigh numbers. The transition between the two types of convection appears to occur gradually with increasing Rayleigh and Taylor numbers. At a Taylor number of 10 7 the differential rotation pattern consists of an inner cylindrical region of subrotation and an outer cylindrical shell of superrotation manifest at the outer boundary as an equatorial superrotation and a high latitude subrotation. The differential rotation pattern is similar at Ta=10 8 and low Rayleigh number. Cylindrical shells of alternately directed mean zonal flow begin to develop at Ta=10 8 and R=50R c and at Ta=10 9 and R=25R c . This pattern is seen on the outer surface as a latitudinally-banded zonal flow consisting of an equatorial superrotation, a middle and high latitude subrotation, and a polar superrotation. At Ta=10 9 and R=50R c the differential rotation appears at the surface as a broad eastward flow in the equatorial region with alternating bands of westward and eastward flow at high latitudes. copyright 1995 American Institute of Physics
Beyond the magic number four: Remapping high-capacity, pre-attentive, fragile working memory
Zerr, P.; Gayet, S.; Mulder, K.T.; Sligte, I.G.; Stigchel, S. van der
2017-01-01
Visual short term memory allows us to access visual information after termination of its retinal input. Generally, a distinction is made between a robust, capacity-limited form (working memory, WM) and high-capacity, pre-attentive, maskable forms (sensory memory, e.g. fragile memory, FM). Eye
Highly Mobile Students: Educational Problems and Possible Solutions. ERIC/CUE Digest, Number 73.
ERIC Clearinghouse on Urban Education, New York, NY.
The following two types of student mobility stand out as causing educational problems: (1) inner-city mobility, which is prompted largely by fluctuations in the job market; and (2) intra-city mobility, which is caused by upward mobility or by poverty and homelessness. Most research indicates that high mobility negatively affects student…
Home advantage in high-level volleyball varies according to set number.
Marcelino, Rui; Mesquita, Isabel; Palao Andrés, José Manuel; Sampaio, Jaime
2009-01-01
The aim of the present study was to identify the probability of winning each Volleyball set according to game location (home, away). Archival data was obtained from 275 sets in the 2005 Men's Senior World League and 65,949 actions were analysed. Set result (win, loss), game location (home, away), set number (first, second, third, fourth and fifth) and performance indicators (serve, reception, set, attack, dig and block) were the variables considered in this study. In a first moment, performance indicators were used in a logistic model of set result, by binary logistic regression analysis. After finding the adjusted logistic model, the log-odds of winning the set were analysed according to game location and set number. The results showed that winning a set is significantly related to performance indicators (Chisquare(18)=660.97, padvantage at the beginning of the game (first set) and in the two last sets of the game (fourth and fifth sets), probably due to facilities familiarity and crowd effects. Different game actions explain these advantages and showed that to win the first set is more important to take risk, through a better performance in the attack and block, and to win the final set is important to manage the risk through a better performance on the reception. These results may suggest intra-game variation in home advantage and can be most useful to better prepare and direct the competition. Key pointsHome teams always have more probability of winning the game than away teams.Home teams have higher performance in reception, set and attack in the total of the sets.The advantage of home teams is more pronounced at the beginning of the game (first set) and in two last sets of the game (fourth and fifth sets) suggesting intra-game variation in home advantage.Analysis by sets showed that home teams have a better performance in the attack and block in the first set and in the reception in the third and fifth sets.
Muons in air showers at the Pierre Auger Observatory: mean number in highly inclined events
Aab, A.; Abreu, P.; Aglietta, M.; Boháčová, Martina; Chudoba, Jiří; Ebr, Jan; Mandát, Dušan; Nečesal, Petr; Palatka, Miroslav; Pech, Miroslav; Prouza, Michael; Řídký, Jan; Schovánek, Petr; Trávníček, Petr; Vícha, Jakub
2015-01-01
Roč. 91, č. 3 (2015), , "032003-1"-"032003-12" ISSN 1550-7998 R&D Projects: GA MŠk(CZ) LG13007; GA MŠk(CZ) 7AMB14AR005; GA ČR(CZ) GA14-17501S Institutional support: RVO:68378271 Keywords : Pierre Auger Observatory * air shower s * ultrahigh energies * cosmic rays * detector Subject RIV: BF - Elementary Particles and High Energy Physics Impact factor: 4.643, year: 2014
Magnetic reconnection and stochastic plasmoid chains in high-Lundquist-number plasmas
Loureiro, N. F.
2012-04-13
A numerical study of magnetic reconnection in the large-Lundquist-number (S), plasmoid-dominated regime is carried out for S up to 10 7. The theoretical model of Uzdensky [Phys. Rev. Lett. 105, 235002 (2010)] is confirmed and partially amended. The normalized reconnection rate is Ẽ eff ∼ 0.02 independently of S for S ≫ 10 4. The plasmoid flux (ψ) and half-width (w x) distribution functions scale as f (ψ) ∼ - ψ -2 and f (w x) ∼ w x -2. The joint distribution of ψ and w x shows that plasmoids populate a triangular region w x ≲ψ/B 0, where B 0 is the reconnecting field. It is argued that this feature is due to plasmoid coalescence. Macroscopic "monster" plasmoids with w x ∼ 10 % of the system size are shown to emerge in just a few Alfvén times, independently of S, suggesting that large disruptive events are an inevitable feature of large-S reconnection. © 2012 American Institute of Physics.
Temperley, D.J.
1976-01-01
In this paper we consider fully developed, laminar, unidirectional flow of uniformly conducting, incompressible fluid through a rectangular duct of uniform cross-section. An externally applied magnetic field acts parallel to one pair of opposite walls and induced velocity and magnetic fields are generated in a direction parallel to the axis of the duct. The governing equations and boundary conditions for the latter fields are introduced and study is then concentrated on the special case of a duct having all walls non-conducting. For values of the Hartmann number M>>1, classical asymptotic analysis reveals the leading terms in the expansions of the induced fields in all key regions, with the exception of certain boundary layers near the corners of the duct. The order of magnitude of the affect of the latter layers on the flow-rate is discussed and closed-form solutions are obtained for the induced fields near the corners of the duct. Attempts were made to formulate a concise Principle of Minimum Singularity to enable the correct choice of eigen functions for the various field components in the boundary layers on the walls parallel to the applied field. It was found, however, that these components are best found by taking the outer expansion of the closed-form solution in those boundary-layers near the corners of the duct where classical asymptotic analysis is not applicable. (author)
Magnetic reconnection and stochastic plasmoid chains in high-Lundquist-number plasmas
Loureiro, N. F.; Samtaney, Ravi; Schekochihin, A. A.; Uzdensky, D. A.
2012-01-01
A numerical study of magnetic reconnection in the large-Lundquist-number (S), plasmoid-dominated regime is carried out for S up to 10 7. The theoretical model of Uzdensky [Phys. Rev. Lett. 105, 235002 (2010)] is confirmed and partially amended. The normalized reconnection rate is Ẽ eff ∼ 0.02 independently of S for S ≫ 10 4. The plasmoid flux (ψ) and half-width (w x) distribution functions scale as f (ψ) ∼ - ψ -2 and f (w x) ∼ w x -2. The joint distribution of ψ and w x shows that plasmoids populate a triangular region w x ≲ψ/B 0, where B 0 is the reconnecting field. It is argued that this feature is due to plasmoid coalescence. Macroscopic "monster" plasmoids with w x ∼ 10 % of the system size are shown to emerge in just a few Alfvén times, independently of S, suggesting that large disruptive events are an inevitable feature of large-S reconnection. © 2012 American Institute of Physics.
Technique for forcing high Reynolds number isotropic turbulence in physical space
Palmore, John A.; Desjardins, Olivier
2018-03-01
Many common engineering problems involve the study of turbulence interaction with other physical processes. For many such physical processes, solutions are expressed most naturally in physical space, necessitating the use of physical space solutions. For simulating isotropic turbulence in physical space, linear forcing is a commonly used strategy because it produces realistic turbulence in an easy-to-implement formulation. However, the method resolves a smaller range of scales on the same mesh than spectral forcing. We propose an alternative approach for turbulence forcing in physical space that uses the low-pass filtered velocity field as the basis of the forcing term. This method is shown to double the range of scales captured by linear forcing while maintaining the flexibility and low computational cost of the original method. This translates to a 60% increase of the Taylor microscale Reynolds number on the same mesh. An extension is made to scalar mixing wherein a scalar field is forced to have an arbitrarily chosen, constant variance. Filtered linear forcing of the scalar field allows for control over the length scale of scalar injection, which could be important when simulating scalar mixing.
Scaling of Polymer Degradation Rate within a High-Reynolds-Number Turbulent Boundary Layer
Elbing, Brian; Solomon, Michael; Perlin, Marc; Dowling, David; Ceccio, Steven
2009-11-01
An experiment conducted at the U.S. Navy's Large Cavitation Channel on a 12.9 m long flat-plate test model produced the first quantitative measurements of polymer molecular weight within a turbulent boundary layer. Testing was conducted at speeds to 20 m/s and downstream distance based Reynolds numbers to 220 million. These results showed that the rate of polymer degradation by scission of the polymer chains increases with increased speed, downstream distance and surface roughness. With the surface fully rough at 20 m/s there was no measureable level of drag reduction at the first measurement location (0.56 m downstream of injection). These results are scaled with the assumption that the rate of degradation is dependent on the polymer residence time in the flow and the local shear rate. A successful collapse of the data within the measurement uncertainty was achieved over a range of flow speed (6.6 to 20 m/s), surface roughness (smooth and fully rough) and downstream distance from injection (0.56 to 9.28 m).
Disturbances to Air-Layer Skin-Friction Drag Reduction at High Reynolds Numbers
Dowling, David; Elbing, Brian; Makiharju, Simo; Wiggins, Andrew; Perlin, Marc; Ceccio, Steven
2009-11-01
Skin friction drag on a flat surface may be reduced by more than 80% when a layer of air separates the surface from a flowing liquid compared to when such an air layer is absent. Past large-scale experiments utilizing the US Navy's Large Cavitation Channel and a flat-plate test model 3 m wide and 12.9 m long have demonstrated air layer drag reduction (ALDR) on both smooth and rough surfaces at water flow speeds sufficient to reach downstream-distance-based Reynolds numbers exceeding 100 million. For these experiments, the incoming flow conditions, surface orientation, air injection geometry, and buoyancy forces all favored air layer formation. The results presented here extend this prior work to include the effects that vortex generators and free stream flow unsteadiness have on ALDR to assess its robustness for application to ocean-going ships. Measurements include skin friction, static pressure, airflow rate, video of the flow field downstream of the injector, and profiles of the flowing air-water mixture when the injected air forms bubbles, when it is in transition to an air layer, and when the air layer is fully formed. From these, and the prior measurements, ALDR's viability for full-scale applications is assessed.
Ishikawa Shumpei
2006-02-01
Full Text Available Abstract Background DNA copy number alterations are one of the main characteristics of the cancer cell karyotype and can contribute to the complex phenotype of these cells. These alterations can lead to gains in cellular oncogenes as well as losses in tumor suppressor genes and can span small intervals as well as involve entire chromosomes. The ability to accurately detect these changes is central to understanding how they impact the biology of the cell. Results We describe a novel algorithm called CARAT (Copy Number Analysis with Regression And Tree that uses probe intensity information to infer copy number in an allele-specific manner from high density DNA oligonuceotide arrays designed to genotype over 100, 000 SNPs. Total and allele-specific copy number estimations using CARAT are independently evaluated for a subset of SNPs using quantitative PCR and allelic TaqMan reactions with several human breast cancer cell lines. The sensitivity and specificity of the algorithm are characterized using DNA samples containing differing numbers of X chromosomes as well as a test set of normal individuals. Results from the algorithm show a high degree of agreement with results from independent verification methods. Conclusion Overall, CARAT automatically detects regions with copy number variations and assigns a significance score to each alteration as well as generating allele-specific output. When coupled with SNP genotype calls from the same array, CARAT provides additional detail into the structure of genome wide alterations that can contribute to allelic imbalance.
Brahim Berrabah
2017-02-01
Full Text Available Numerical predictions of three-dimensional flow and heat transfer are performed for a two-pass square channel with 45° staggered ribs in non-orthogonally mode-rotation using the second moment closure model. At Reynolds number of 25,000, the rotation numbers studied were 0, 0.24, 0.35 and 1.00. The density ratios were 0.13, 0.23 and 0.50. The results show that at high buoyancy parameter and high rotation number with a low density ratio, the flow in the first passage is governed by the secondary flow induced by the rotation whereas the secondary flow induced by the skewed ribs was almost distorted. As a result the heat transfer rate is enhanced on both co-trailing and co-leading sides compared to low and medium rotation number. In contrast, for the second passage, the rotation slightly reduces the heat transfer rate on co-leading side at high rotation number with a low density ratio and degrades it significantly on both co-trailing and co-leading sides at high buoyancy parameter compared to the stationary, low and medium rotation numbers. The numerical results are in fair agreement with available experimental data in the bend region and the second passage, while in the first passage were overestimated at low and medium rotation numbers.
Ral, Jean-Philippe; Whan, Alex; Larroque, Oscar; Leyne, Emmett; Pritchard, Jeni; Dielen, Anne-Sophie; Howitt, Crispin A; Morell, Matthew K; Newberry, Marcus
2016-01-01
Late maturity α-amylase (LMA) and preharvest sprouting (PHS) are genetic defects in wheat. They are both characterized by the expression of specific isoforms of α-amylase in particular genotypes in the grain prior to harvest. The enhanced expression of α-amylase in both LMA and PHS results in a reduction in Falling Number (FN), a test of gel viscosity, and subsequent downgrading of the grain, along with a reduced price for growers. The FN test is unable to distinguish between LMA and PHS; thus, both defects are treated similarly when grain is traded. However, in PHS-affected grains, proteases and other degradative process are activated, and this has been shown to have a negative impact on end product quality. No studies have been conducted to determine whether LMA is detrimental to end product quality. This work demonstrated that wheat in which an isoform α-amylase (TaAmy3) was overexpressed in the endosperm of developing grain to levels of up to 100-fold higher than the wild-type resulted in low FN similar to those seen in LMA- or PHS-affected grains. This increase had no detrimental effect on starch structure, flour composition and enhanced baking quality, in small-scale 10-g baking tests. In these small-scale tests, overexpression of TaAmy3 led to increased loaf volume and Maillard-related browning to levels higher than those in control flours when baking improver was added. These findings raise questions as to the validity of the assumption that (i) LMA is detrimental to end product quality and (ii) a low FN is always indicative of a reduction in quality. This work suggests the need for a better understanding of the impact of elevated expression of specific α-amylase on end product quality. © 2015 The Authors. Plant Biotechnology Journal published by Society for Experimental Biology and The Association of Applied Biologists and John Wiley & Sons Ltd.
Yilmaz, Özlem Ceyhan; Pires, Oscar; Munduate, Xabier
2017-01-01
This paper summarizes the results of a blind test campaign organized in the AVATAR project to predict the high Reynolds number performance of a wind turbine airfoil for wind turbine applications. The DU00-W-210 airfoil was tested in the DNW-HDG pressurized wind tunnel in order to investigate...... the flow at high Reynolds number range from 3 to 15 million which is the operating condition of the future large 10MW+ offshore wind turbine rotors. The results of the experiment was used in a blind test campaign to test the prediction capability of the CFD tools used in the wind turbine rotor simulations....... As a result of the blind test campaign it was found that although the codes are in general capable of predicting increased max lift and decreased minimum drag with Re number, the Re trend predictions in particular the glide ratio (lift over drag) need further improvement. In addition to that, the significant...
Fractal-like Distributions over the Rational Numbers in High-throughput Biological and Clinical Data
Trifonov, Vladimir; Pasqualucci, Laura; Dalla-Favera, Riccardo; Rabadan, Raul
2011-12-01
Recent developments in extracting and processing biological and clinical data are allowing quantitative approaches to studying living systems. High-throughput sequencing (HTS), expression profiles, proteomics, and electronic health records (EHR) are some examples of such technologies. Extracting meaningful information from those technologies requires careful analysis of the large volumes of data they produce. In this note, we present a set of fractal-like distributions that commonly appear in the analysis of such data. The first set of examples are drawn from a HTS experiment. Here, the distributions appear as part of the evaluation of the error rate of the sequencing and the identification of tumorogenic genomic alterations. The other examples are obtained from risk factor evaluation and analysis of relative disease prevalence and co-mordbidity as these appear in EHR. The distributions are also relevant to identification of subclonal populations in tumors and the study of quasi-species and intrahost diversity of viral populations.
Chromosomal evolution of the Canidae. I. Species with high diploid numbers.
Wayne, R K; Nash, W G; O'Brien, S J
1987-01-01
The Giemsa banding patterns of seven canid species, including the grey wolf (Canis lupus), the maned wolf (Chrysocyon brachyurus), the bush dog (Speothos venaticus), the crab-eating fox (Cerdocyon thous), the grey fox (Urocyon cinereoargenteus), the bat-eared fox (Otocyon megalotis), and the fennec (Fennecus zerda), are presented and compared. Relative to other members of Canidae, these species have high diploid complements (2n greater than 64) consisting of largely acrocentric chromosomes. They show a considerable degree of chromosome homoeology, but relative to the grey wolf, each species is either missing chromosomes or has unique chromosomal additions and rearrangements. Differences in chromosome morphology among the seven species were used to reconstruct their phylogenetic history. The results suggest that the South American canids are closely related to each other and are derived from a wolf-like progenitor. The fennec and the bat-eared fox seem to be recent derivatives of a lineage that branched early from the wolf-like canids and which also includes the grey fox.
ON THE APPARENT NARROWING OF RADIO RECOMBINATION LINES AT HIGH PRINCIPAL QUANTUM NUMBERS
Alexander, J.; Gulyaev, S.
2012-01-01
We critically analyze the Bell et al. findings on 'anomalous' widths of high-order hydrogen radio recombination lines in the Orion Nebula at 6 GHz. We review their method of modified frequency switching and show that the way this method is used for large Δn is not optimal and can lead to misinterpretation of measured spectral line parameters. Using a model of the Orion Nebula, conventional broadening theory, and Monte Carlo simulation, we determine a transition zone n = 224, ..., 241 (Δn = 11, ..., 14), where measurement errors grow quickly with n and become comparable with the measurement values themselves. When system noise and spectrum channelization are accounted for, our simulation predicts 'processed' line narrowing in the transition zone similar to that reported by Bell et al. We find good agreement between our simulation results and their findings, both in line temperatures and widths. We conclude, therefore, that Bell et al.'s findings do not indicate a need to revise Stark broadening theory.
High-Reynolds Number Active Blowing Semi-Span Force Measurement System Development
Lynn, Keith C.; Rhew, Ray D.; Acheson, Michael J.; Jones, Gregory S.; Milholen, William E.; Goodliff, Scott L.
2012-01-01
Recent wind-tunnel tests at the NASA Langley Research Center National Transonic Facility utilized high-pressure bellows to route air to the model for evaluating aircraft circulation control. The introduction of these bellows within the Sidewall Model Support System significantly impacted the performance of the external sidewall mounted semi-span balance. As a result of this impact on the semi-span balance measurement performance, it became apparent that a new capability needed to be built into the National Transonic Facility s infrastructure to allow for performing pressure tare calibrations on the balance in order to properly characterize its performance under the influence of static bellows pressure tare loads and bellows thermal effects. The objective of this study was to design both mechanical calibration hardware and an experimental calibration design that can be employed at the facility in order to efficiently and precisely perform the necessary loadings in order to characterize the semi-span balance under the influence of multiple calibration factors (balance forces/moments and bellows pressure/temperature). Using statistical design of experiments, an experimental design was developed allowing for strategically characterizing the behavior of the semi-span balance for use in circulation control and propulsion-type flow control testing at the National Transonic Facility.
Drag reduction using wrinkled surfaces in high Reynolds number laminar boundary layer flows
Raayai-Ardakani, Shabnam; McKinley, Gareth H.
2017-09-01
Inspired by the design of the ribbed structure of shark skin, passive drag reduction methods using stream-wise riblet surfaces have previously been developed and tested over a wide range of flow conditions. Such textures aligned in the flow direction have been shown to be able to reduce skin friction drag by 4%-8%. Here, we explore the effects of periodic sinusoidal riblet surfaces aligned in the flow direction (also known as a "wrinkled" texture) on the evolution of a laminar boundary layer flow. Using numerical analysis with the open source Computational Fluid Dynamics solver OpenFOAM, boundary layer flow over sinusoidal wrinkled plates with a range of wavelength to plate length ratios ( λ / L ), aspect ratios ( 2 A / λ ), and inlet velocities are examined. It is shown that in the laminar boundary layer regime, the riblets are able to retard the viscous flow inside the grooves creating a cushion of stagnant fluid that the high-speed fluid above can partially slide over, thus reducing the shear stress inside the grooves and the total integrated viscous drag force on the plate. Additionally, we explore how the boundary layer thickness, local average shear stress distribution, and total drag force on the wrinkled plate vary with the aspect ratio of the riblets as well as the length of the plate. We show that riblets with an aspect ratio of close to unity lead to the highest reduction in the total drag, and that because of the interplay between the local stress distribution on the plate and stream-wise evolution of the boundary layer the plate has to exceed a critical length to give a net decrease in the total drag force.
Ghada Al-Kafaji
2013-01-01
Full Text Available Oxidative damage to mitochondrial DNA (mtDNA has been linked to the pathogenicity of diabetic nephropathy. We tested the hypothesis that mtDNA copy number may be increased in human mesangial cells in response to high glucose-induced reactive oxygen species (ROS to compensate for damaged mtDNA. The effect of manganese superoxide dismutase mimetic (MnTBAP on glucose-induced mtDNA copy number was also examined. The copy number of mtDNA was determined by real-time PCR in human mesangial cells cultured in 5 mM glucose, 25 mM glucose, and mannitol (osmotic control, as well as in cells cultured in 25 mM glucose in the presence and absence of 200 μM MnTBAP. Intracellular ROS was assessed by confocal microscopy and flow cytometry in human mesangial cells. The copy number of mtDNA was significantly increased when human mesangial cells were incubated with 25 mM glucose compared to 5 mM glucose and mannitol. In addition, 25 mM glucose rapidly generated ROS in the cells, which was not detected in 5 mM glucose. Furthermore, mtDNA copy number was significantly decreased and maintained to normal following treatment of cells with 25 mM glucose and MnTBAP compared to 25 mM glucose alone. Inclusion of MnTBAP during 25 mM glucose incubation inhibited mitochondrial superoxide in human mesangial cells. Increased mtDNA copy number in human mesangial cells by high glucose could contribute to increased mitochondrial superoxide, and prevention of mtDNA copy number could have potential in retarding the development of diabetic nephropathy.
Verma, Siddhartha; Blanquart, Guillaume; P. K. Yeung Collaboration
2011-11-01
Accurate simulation of high Schmidt number scalar transport in turbulent flows is essential to studying pollutant dispersion, weather, and several oceanic phenomena. Batchelor's theory governs scalar transport in such flows, but requires further validation at high Schmidt and high Reynolds numbers. To this end, we use a new approach with the velocity field fully resolved, but the scalar field only partially resolved. The grid used is fine enough to resolve scales up to the viscous-convective subrange where the decaying slope of the scalar spectrum becomes constant. This places the cutoff wavenumber between the Kolmogorov scale and the Batchelor scale. The subgrid scale terms, which affect transport at the supergrid scales, are modeled under the assumption that velocity fluctuations are negligible beyond this cutoff wavenumber. To ascertain the validity of this technique, we performed a-priori testing on existing DNS data. This Velocity-Resolved LES (VR-LES) technique significantly reduces the computational cost of turbulent simulations of high Schmidt number scalars, and yet provides valuable information of the scalar spectrum in the viscous-convective subrange.
Wang, Yi; Han, Ge; Lu, Xingen; Zhu, Junqiang
2018-02-01
Wedge diffuser is widely used in centrifugal compressors due to its high performance and compact size. This paper is aimed to research the influence of wedge diffuser blade number and divergence angle on centrifugal compressor performance. The impact of wedge diffuser blade number on compressor stage performance is investigated, and then the wedge diffusers with different divergence angle are studied by varying diffuser wedge angle and blade number simultaneously. It is found that wedge diffuser with 27 blades could have about 0.8% higher adiabatic efficiency and 0.14 higher total pressure ratio than the wedge diffuser with 19 blades and the best compressor performance is achieved when diffuser divergence angle is 8.3°.These results could give some advices on centrifugal compressor design.
Nik-Zainal, Serena; Strick, Reiner; Storer, Mekayla; Huang, Ni; Rad, Roland; Willatt, Lionel; Fitzgerald, Tomas; Martin, Vicki; Sandford, Richard; Carter, Nigel P; Janecke, Andreas R; Renner, Stefan P; Oppelt, Patricia G; Oppelt, Peter; Schulze, Christine; Brucker, Sara; Hurles, Matthew; Beckmann, Matthias W; Strissel, Pamela L; Shaw-Smith, Charles
2011-03-01
Congenital malformations involving the Müllerian ducts are observed in around 5% of infertile women. Complete aplasia of the uterus, cervix, and upper vagina, also termed Müllerian aplasia or Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome, occurs with an incidence of around 1 in 4500 female births, and occurs in both isolated and syndromic forms. Previous reports have suggested that a proportion of cases, especially syndromic cases, are caused by variation in copy number at different genomic loci. In order to obtain an overview of the contribution of copy number variation to both isolated and syndromic forms of Müllerian aplasia, copy number assays were performed in a series of 63 cases, of which 25 were syndromic and 38 isolated. A high incidence (9/63, 14%) of recurrent copy number variants in this cohort is reported here. These comprised four cases of microdeletion at 16p11.2, an autism susceptibility locus not previously associated with Müllerian aplasia, four cases of microdeletion at 17q12, and one case of a distal 22q11.2 microdeletion. Microdeletions at 16p11.2 and 17q12 were found in 4/38 (10.5%) cases with isolated Müllerian aplasia, and at 16p11.2, 17q12 and 22q11.2 (distal) in 5/25 cases (20%) with syndromic Müllerian aplasia. The finding of microdeletion at 16p11.2 in 2/38 (5%) of isolated and 2/25 (8%) of syndromic cases suggests a significant contribution of this copy number variant alone to the pathogenesis of Müllerian aplasia. Overall, the high incidence of recurrent copy number variants in all forms of Müllerian aplasia has implications for the understanding of the aetiopathogenesis of the condition, and for genetic counselling in families affected by it.
High fat feeding affects the number of GPR120 cells and enteroendocrine cells in the mouse stomach
Patricia eWidmayer
2015-02-01
Full Text Available Long-term intake of dietary fat is supposed to be associated with adaptive reactions of the organism and it is assumptive that this is particularly true for fat responsive epithelial cells in the mucosa of the gastrointestinal tract. Recent studies suggest that epithelial cells expressing the receptor for medium and long chain fatty acids, GPR120 (FFAR4, may operate as fat sensors. Changes in expression level and/or cell density are supposed to be accompanied with a consumption of high fat (HF diet. To assess whether feeding a HF diet might impact on the expression of fatty acid receptors or the number of lipid sensing cells as well as enteroendocrine cell populations, gastric tissue samples of non-obese and obese mice were compared using a real time PCR and immunohistochemical approach. In this study, we have identified GPR120 cells in the corpus region of the mouse stomach which appeared to be brush cells. Monitoring the effect of HF diet on the expression of GPR120 revealed that after 3 weeks and 6 months the level of mRNA for GPR120 in the tissue was significantly increased which coincided with and probably reflected a significant increase in the number of GPR120 positive cells in the corpus region; in contrast, within the antrum region, the number of GPR120 cells decreased. Furthermore, dietary fat intake also led to changes in the number of enteroendocrine cells producing either ghrelin or gastrin. After 3 weeks and even more pronounced after 6 months the number of ghrelin cells and gastrin cells was significantly increased. These results imply that a HF diet leads to significant changes in the cellular repertoire of the stomach mucosa. Whether these changes are a consequence of the direct exposure to high fat in the luminal content or a physiological response to the high level of fat in the body remains elusive.
Ranieri, M L; Huck, J R; Sonnen, M; Barbano, D M; Boor, K J
2009-10-01
The grade A Pasteurized Milk Ordinance specifies minimum processing conditions of 72 degrees C for at least 15 s for high temperature, short time (HTST) pasteurized milk products. Currently, many US milk-processing plants exceed these minimum requirements for fluid milk products. To test the effect of pasteurization temperatures on bacterial numbers in HTST pasteurized milk, 2% fat raw milk was heated to 60 degrees C, homogenized, and treated for 25 s at 1 of 4 different temperatures (72.9, 77.2, 79.9, or 85.2 degrees C) and then held at 6 degrees C for 21 d. Aerobic plate counts were monitored in pasteurized milk samples at d 1, 7, 14, and 21 postprocessing. Bacterial numbers in milk processed at 72.9 degrees C were lower than in milk processed at 85.2 degrees C on each sampling day, indicating that HTST fluid milk-processing temperatures significantly affected bacterial numbers in fluid milk. To assess the microbial ecology of the different milk samples during refrigerated storage, a total of 490 psychrotolerant endospore-forming bacteria were identified using DNA sequence-based subtyping methods. Regardless of processing temperature, >85% of the isolates characterized at d 0, 1, and 7 postprocessing were of the genus Bacillus, whereas more than 92% of isolates characterized at d 14 and 21 postprocessing were of the genus Paenibacillus, indicating that the predominant genera present in HTST-processed milk shifted from Bacillus spp. to Paenibacillus spp. during refrigerated storage. In summary, 1) HTST processing temperatures affected bacterial numbers in refrigerated milk, with higher bacterial numbers in milk processed at higher temperatures; 2) no significant association was observed between genus isolated and pasteurization temperature, suggesting that the genera were not differentially affected by the different processing temperatures; and 3) although typically present at low numbers in raw milk, Paenibacillus spp. are capable of growing to numbers that can
Duvvuri, Subrahmanyam; McKeon, Beverley
2017-03-13
Phase relations between specific scales in a turbulent boundary layer are studied here by highlighting the associated nonlinear scale interactions in the flow. This is achieved through an experimental technique that allows for targeted forcing of the flow through the use of a dynamic wall perturbation. Two distinct large-scale modes with well-defined spatial and temporal wavenumbers were simultaneously forced in the boundary layer, and the resulting nonlinear response from their direct interactions was isolated from the turbulence signal for the study. This approach advances the traditional studies of large- and small-scale interactions in wall turbulence by focusing on the direct interactions between scales with triadic wavenumber consistency. The results are discussed in the context of modelling high Reynolds number wall turbulence.This article is part of the themed issue 'Toward the development of high-fidelity models of wall turbulence at large Reynolds number'. © 2017 The Author(s).
Nichino, Takafumi; Hahn, Seonghyeon; Shariff, Karim
2010-01-01
This slide presentation reviews the Large Eddy Simulation of a high reynolds number Coanda flow that is separated from a round trailing edge of a ciruclation control airfoil. The objectives of the study are: (1) To investigate detailed physics (flow structures and statistics) of the fully turbulent Coanda jet applied to a CC airfoil, by using LES (2) To compare LES and RANS results to figure out how to improve the performance of existing RANS models for this type of flow.
Llena, C; Leyda, A; Forner, L; Garcet, S
2015-03-01
An investigation was conducted in a population of paediatric patients with a high risk of caries in order to assess the association between caries history (CH) and the number of early carious lesions (ECLs) and the frequency and timing of cariogenic food and beverage intake, sugar-containing medication, the frequency and efficacy of tooth brushing, and the use of topical fluorides. Study design: descriptive study. One hundred children aged 6-15 years with≥ ECL of a permanent tooth and not enrolled in any dental health educational or preventive programme were selected. For diagnosis it was used an explorer according to the ICDAS II criteria. The participants completed a closed-list questionnaire on the frequency and timing of cariogenic food intake. There was a nonsignificant tendency to present more ECLs and a greater CH among patients who consumed cariogenic foods and beverages. A significant relationship (pcariogenic beverages and the number of ECL or CH. Using the number of ECLs as dependent variable, regular fluoridated rinses (p=0.003), frequent sugar-containing medication (p=0.007), and cariogenic beverage consumption (p=0.024) were identified as explanatory parameters in the linear regression model. The Student t-test was used to compare ECL and CH with dietetic factors, fluoridated rinses, sugar- containing medicines, and the frequency and efficacy of tooth brushing. Linear regression analysis correlated the number of ECLs to the mentioned explanatory variables. The frequent consumption of sugary beverages and medications, and failure to regularly use fluoridated rinses, were positively correlated to an increased number of ECLs in patients with a high prevalence of caries.
Hollox, E J; Atia, T; Cross, G; Parkin, T; Armour, J A L
2002-11-01
Subtelomeric regions of the human genome are gene rich, with a high level of sequence polymorphism. A number of clinical conditions, including learning disability, have been attributed to subtelomeric deletions or duplications, but screening for deletion in these regions using conventional cytogenetic methods and fluorescence in situ hybridisation (FISH) is laborious. Here we report that a new method, multiplex amplifiable probe hybridisation (MAPH), can be used to screen for copy number at subtelomeric regions. We have constructed a set of MAPH probes with each subtelomeric region represented at least once, so that one gel lane can assay copy number at all chromosome ends in one person. Each probe has been sequenced and, where possible, its position relative to the telomere determined by comparison with mapped clones. The sensitivity of the probes has been characterised on a series of cytogenetically verified positive controls and 83 normal controls were used to assess the frequency of polymorphic copy number with no apparent phenotypic effect. We have also used MAPH to test a cohort of 37 people selected from males referred for fragile X syndrome testing and found six changes that were confirmed by dosage PCR. MAPH can be used to screen subtelomeric regions of chromosomes for deletions and duplications before confirmation by FISH or dosage PCR. The high throughput nature of this technique allows it to be used for large scale screening of subtelomeric copy number, before confirmation by FISH. In practice, the availability of a rapid and efficient screen may allow subtelomeric analysis to be applied to a wider selection of patients than is currently possible using FISH alone.
Al Amir, Issam; Dubayle, David; Héron, Anne; Delayre-Orthez, Carine; Anton, Pauline M
2017-12-01
Links between food and inflammatory bowel diseases (IBDs) are often suggested, but the role of food processing has not been extensively studied. Heat treatment is known to cause the loss of nutrients and the appearance of neoformed compounds such as Maillard reaction products. Their involvement in gut inflammation is equivocal, as some may have proinflammatory effects, whereas other seem to be protective. As IBDs are associated with the recruitment of immune cells, including mast cells, we raised the hypothesis that dietary Maillard reaction products generated through heat treatment of food may limit the colitic response and its associated recruitment of mast cells. An experimental model of colitis was used in mice submitted to mildly and highly heated rodent food. Adult male mice were divided in 3 groups and received nonheated, mildly heated, or highly heated chow during 21 days. In the last week of the study, each group was split into 2 subgroups, submitted or not (controls) to dextran sulfate sodium (DSS) colitis. Weight variations, macroscopic lesions, colonic myeloperoxidase activity, and mucosal mast cell number were evaluated at the end of the experiment. Only highly heated chow significantly prevented DSS-induced weight loss, myeloperoxidase activity, and mast cell number increase in the colonic mucosa of DSS-colitic mice. We suggest that Maillard reaction products from highly heated food may limit the occurrence of inflammatory phases in IBD patients. Copyright © 2017 Elsevier Inc. All rights reserved.
Two-step simulation of velocity and passive scalar mixing at high Schmidt number in turbulent jets
Rah, K. Jeff; Blanquart, Guillaume
2016-11-01
Simulation of passive scalar in the high Schmidt number turbulent mixing process requires higher computational cost than that of velocity fields, because the scalar is associated with smaller length scales than velocity. Thus, full simulation of both velocity and passive scalar with high Sc for a practical configuration is difficult to perform. In this work, a new approach to simulate velocity and passive scalar mixing at high Sc is suggested to reduce the computational cost. First, the velocity fields are resolved by Large Eddy Simulation (LES). Then, by extracting the velocity information from LES, the scalar inside a moving fluid blob is simulated by Direct Numerical Simulation (DNS). This two-step simulation method is applied to a turbulent jet and provides a new way to examine a scalar mixing process in a practical application with smaller computational cost. NSF, Samsung Scholarship.
Xu, G S; Wan, B N; Wang, H Q; Guo, H Y; Naulin, V; Rasmussen, J Juul; Nielsen, A H; Wu, X Q; Yan, N; Chen, L; Shao, L M; Chen, R; Wang, L; Zhang, W
2016-03-04
A new model for the low-to-high (L-H) confinement transition has been developed based on a new paradigm for turbulence suppression by velocity shear [G. M. Staebler et al., Phys. Rev. Lett. 110, 055003 (2013)]. The model indicates that the L-H transition can be mediated by a shift in the radial wave number spectrum of turbulence, as evidenced here, for the first time, by the direct observation of a turbulence radial wave number spectral shift and turbulence structure tilting prior to the L-H transition at tokamak edge by direct probing. This new mechanism does not require a pretransition overshoot in the turbulent Reynolds stress, shunting turbulence energy to zonal flows for turbulence suppression as demonstrated in the experiment.
Kislenko, S. A.
2018-01-01
The work is focused on the investigation of the effect of solvent and carbon cathode morphology on the performance of Li-air batteries. Molecular dynamics simulation was used to explore the interfacial behavior of the main reactants (O2 and Li+) of the oxygen reduction reaction in high donor number solvent dimethyl sulfoxide (DMSO) at the following carbon surfaces: graphene plane, graphene edge, nanotube. It was shown that the adsorption barrier of O2 molecules decreases in the order graphene plane > nanotube > graphene edge, leading to the fastest adsorption kinetics on graphene edges. Strong solvation of Li+ in DMSO prevents ions adsorption on defect-free graphene planes and nanotubes, which is qualitatively different from low donor number solvents, such as acetonitrile. It can be concluded from these results, that nucleation and growth of discharge products in DMSO is shifted from the surface towards the solvent bulk that, in turn, leads to capacity increase of Li-air batteries.
Kilgore, R. A.; Dress, D. A.
1984-01-01
During the time which has passed since the construction of the first wind tunnel in 1870, wind tunnels have been developed to a high degree of sophistication. However, their development has consistently failed to keep pace with the demands placed on them. One of the more serious problems to be found with existing transonic wind tunnels is their inability to test subscale aircraft models at Reynolds numbers sufficiently near full-scale values to ensure the validity of using the wind tunnel data to predict flight characteristics. The Reynolds number capability of a wind tunnel may be increased by a number of different approaches. However, the best solution in terms of model, balance, and model support loads, as well as in terms of capital and operating cost appears to be related to the reduction of the temperature of the test gas to cryogenic temperatures. The present paper has the objective to review the evolution of the cryogenic wind tunnel concept and to describe its more important advantages.
Frouzakis, C. E.; Boulouchos, K.
2005-12-15
This comprehensive illustrated final report for the Swiss Federal Office of Energy (SFOE) reports on the work done at the Swiss Federal Institute of Technology in Zurich on the numerical simulation of combustion processes at high Reynolds numbers. The authors note that with appropriate extensive calculation effort, results can be obtained that demonstrate a high degree of accuracy. It is noted that a large part of the project work was devoted to the development of algorithms for the simulation of the combustion processes. Application work is also discussed with research on combustion stability being carried on. The direct numerical simulation (DNS) methods used are described and co-operation with other institutes is noted. The results of experimental work are compared with those provided by simulation and are discussed in detail. Conclusions and an outlook round off the report.
Clay, M. P.; Yeung, P. K.; Buaria, D.; Gotoh, T.
2017-11-01
Turbulent mixing at high Schmidt number is a multiscale problem which places demanding requirements on direct numerical simulations to resolve fluctuations down the to Batchelor scale. We use a dual-grid, dual-scheme and dual-communicator approach where velocity and scalar fields are computed by separate groups of parallel processes, the latter using a combined compact finite difference (CCD) scheme on finer grid with a static 3-D domain decomposition free of the communication overhead of memory transposes. A high degree of scalability is achieved for a 81923 scalar field at Schmidt number 512 in turbulence with a modest inertial range, by overlapping communication with computation whenever possible. On the Cray XE6 partition of Blue Waters, use of a dedicated thread for communication combined with OpenMP locks and nested parallelism reduces CCD timings by 34% compared to an MPI baseline. The code has been further optimized for the 27-petaflops Cray XK7 machine Titan using GPUs as accelerators with the latest OpenMP 4.5 directives, giving 2.7X speedup compared to CPU-only execution at the largest problem size. Supported by NSF Grant ACI-1036170, the NCSA Blue Waters Project with subaward via UIUC, and a DOE INCITE allocation at ORNL.
Monty, J.P.; Lien, K.; Chong, M.S. [University of Melbourne, Department of Mechanical Engineering, Parkville, VIC (Australia); Allen, J.J. [New Mexico State University, Department of Mechanical Engineering, Las Cruces, NM (United States)
2011-12-15
A high Reynolds number boundary-layer wind-tunnel facility at New Mexico State University was fitted with a regularly distributed braille surface. The surface was such that braille dots were closely packed in the streamwise direction and sparsely spaced in the spanwise direction. This novel surface had an unexpected influence on the flow: the energy of the very large-scale features of wall turbulence (approximately six-times the boundary-layer thickness in length) became significantly attenuated, even into the logarithmic region. To the author's knowledge, this is the first experimental study to report a modification of 'superstructures' in a rough-wall turbulent boundary layer. The result gives rise to the possibility that flow control through very small, passive surface roughness may be possible at high Reynolds numbers, without the prohibitive drag penalty anticipated heretofore. Evidence was also found for the uninhibited existence of the near-wall cycle, well known to smooth-wall-turbulence researchers, in the spanwise space between roughness elements. (orig.)
Sakai, Takaaki; Yamaguchi, Akira; Morisita, Masaki; Iwata, Koji
1998-08-01
The incident of sodium leakage from a main pipe of the secondary heat transport system of Monju fast breeder reactor was caused by the failure of a thermometer well. 'Flow-induced vibration design guide for thermometer wells' (express as 'design guide') was proposed by PNC Working Group to prevent the same cause of the sodium leak incident in future. On this report, applicability of the 'design guide' was estimated to plant conditions in high Reynolds-number(approximately 3x10 5 ∼ 3x10 6 ) involving the supercritical region, by measured data on a vortex synchronized vibration and a turbulence induced vibration. Experiments were performed for cylindrical and taper shaped types of test pieces. As results, reduced velocity (Vr) at onsets of the inline synchronized vibration were evaluated to be grater than 1.0 in the range of experimental conditions. Fluctuating drag and lift coefficients, which were evaluated from power spectrum of turbulence for Vr < 1.0 condition, were 0.01 ∼ 0.05 for drag direction and 0.04 ∼ 0.13 for lift direction. The fluctuating drag and lift coefficients used in the 'design guide' were estimated to be conservative by comparison with these data. Correlation lengths for a cylinder and a taper shaped one in the high Reynolds-number region were estimated to be 1.6 times of the diameter(D) in the maximum case. The measured value of correlation length is enough smaller than the 'design guide' value of 3.0D. Displacement amplitudes of test pieces for Vr < 1.0 conditions were enough smaller (fives times) than calculated values based on the 'design guide'. Consequently, the applicability of the design guide' was confirmed in the range of experiments involving the super critical Reynolds-number region. (author)
Li, Xiaoyi, E-mail: lixy2@utrc.utc.com; Soteriou, Marios C. [United Technologies Research Center, East Hartford, Connecticut 06108 (United States)
2016-08-15
Recent advances in numerical methods coupled with the substantial enhancements in computing power and the advent of high performance computing have presented first principle, high fidelity simulation as a viable tool in the prediction and analysis of spray atomization processes. The credibility and potential impact of such simulations, however, has been hampered by the relative absence of detailed validation against experimental evidence. The numerical stability and accuracy challenges arising from the need to simulate the high liquid-gas density ratio across the sharp interfaces encountered in these flows are key reasons for this. In this work we challenge this status quo by presenting a numerical model able to deal with these challenges, employing it in simulations of liquid jet in crossflow atomization and performing extensive validation of its results against a carefully executed experiment with detailed measurements in the atomization region. We then proceed to the detailed analysis of the flow physics. The computational model employs the coupled level set and volume of fluid approach to directly capture the spatiotemporal evolution of the liquid-gas interface and the sharp-interface ghost fluid method to stably handle high liquid-air density ratio. Adaptive mesh refinement and Lagrangian droplet models are shown to be viable options for computational cost reduction. Moreover, high performance computing is leveraged to manage the computational cost. The experiment selected for validation eliminates the impact of inlet liquid and gas turbulence and focuses on the impact of the crossflow aerodynamic forces on the atomization physics. Validation is demonstrated by comparing column surface wavelengths, deformation, breakup locations, column trajectories and droplet sizes, velocities, and mass rates for a range of intermediate Weber numbers. Analysis of the physics is performed in terms of the instability and breakup characteristics and the features of downstream
Wang, Yonggang, E-mail: wangyg@ustc.edu.cn; Hui, Cong; Liu, Chong; Xu, Chao [Department of Modern Physics, University of Science and Technology of China, Hefei 230026 (China)
2016-04-15
The contribution of this paper is proposing a new entropy extraction mechanism based on sampling phase jitter in ring oscillators to make a high throughput true random number generator in a field programmable gate array (FPGA) practical. Starting from experimental observation and analysis of the entropy source in FPGA, a multi-phase sampling method is exploited to harvest the clock jitter with a maximum entropy and fast sampling speed. This parametrized design is implemented in a Xilinx Artix-7 FPGA, where the carry chains in the FPGA are explored to realize the precise phase shifting. The generator circuit is simple and resource-saving, so that multiple generation channels can run in parallel to scale the output throughput for specific applications. The prototype integrates 64 circuit units in the FPGA to provide a total output throughput of 7.68 Gbps, which meets the requirement of current high-speed quantum key distribution systems. The randomness evaluation, as well as its robustness to ambient temperature, confirms that the new method in a purely digital fashion can provide high-speed high-quality random bit sequences for a variety of embedded applications.
Transition in x-ray yield, mass scaling observed in the high-wire-number, plasma-shell regime
Whitney, K.G.; Pulsifer, P.E.; Apruzese, J.P.; Thornhill, J.W.; Davis, J.; Sanford, T.W.L.; Mock, R.C.; Nash, T.J.
1999-01-01
Initial calculations, based on classical transport coefficients and carried out to predict the efficiency with which the implosion kinetic energy of aluminum Z pinches could be thermalized and converted into kilovolt x-rays, predicted a sharp transition between m 2 and m yield scaling, where m is the aluminum array mass. Later, when ad hoc increases in the heat conductivity and artificial viscosity were introduced into these calculations and the densities that were achieved on axis were sharply reduced, the transition from m 2 to m scaling was found to have shifted, but was otherwise still fairly sharp and well-defined. The location of these breakpoint curves defined the locus of implosion velocities at which the yields would obtain their maximum for different mass arrays. The first such mass breakpoint curve that was calculated is termed hard, while the second is termed soft. Early 24, 30, and 42 aluminum wire experiments on the Saturn accelerator at the Sandia National laboratories confirmed the predictions of the soft breakpoint curve calculations. In this talk, the authors present results from a more recent set of aluminum experiments on Saturn, in which the array mass was varied at a fixed array radius and in which the radius was varied for a fixed mass. In both sets of experiments, the wire numbers were large: in excess of 92 and generally 136 or 192. In this high-wire-number regime, the wire plasmas are calculated to merge to form a plasma shell prior to significant radial implosion. Large wire number has been found to improve the pinch compressibility, and the analysis of these experiments in the shell regime shows that they come very close to the original predictions of the hard breakpoint curve calculations. A discussion of these detailed comparisons will be presented
Sojka, Paul E.; Rodrigues, Neil S.
2015-11-01
The current study investigates the drop characteristics of three Carboxymethylcellulose (CMC) sprays produced by the impingement of two liquid jets. The three water-based solutions used in this work (0.5 wt.-% CMC-7MF, 0.8 wt.-% CMC-7MF, and 1.4 wt.-% CMC-7MF) exhibited strong shear-thinning, non-Newtonian behavior - characterized by the Bird-Carreau rheological model. A generalized Bird-Carreau jet Reynolds number was used as the primary parameter to characterize the drop size and the drop velocity, which were measured using Phase Doppler Anemometry (PDA). PDA optical configuration enabled a drop size measurement range of approximately 2.3 to 116.2 μm. 50,000 drops were measured at each test condition to ensure statistical significance. The arithmetic mean diameter (D10) , Sauter mean diameter (D32) , and mass median diameter (MMD) were used as representative diameters to characterize drop size. The mean axial drop velocity Uz -mean along with its root-mean square Uz -rms were used to characterize drop velocity. Incredibly, measurements for all three CMC liquids and reference DI water sprays seemed to follow a single curve for D32 and MMD drop diameters in the high generalized Bird-Carreau jet Reynolds number range considered in this work (9.21E +03
Kim, Dae-Gun; Koyama, Emiko; Kikkawa, Yoshihiro; Kirihara, Kazuhiro; Naitoh, Yasuhisa; Kim, Deok-Soo; Tokuhisa, Hideo; Kanesato, Masatoshi; Koshizaki, Naoto
2007-01-01
Au/SiO 2 nanocomposite films consisting of an extremely high number density of Au nanoparticles dispersed in a SiO 2 matrix a few nanometres thick were deposited by a co-sputtering method, and employed for molecular conductance measurement by immobilizing and bridging conjugated biphenyl molecules on dispersed Au nanoparticles. The number density of Au nanoparticles in the insulating SiO 2 matrix was approximately 14 000 μm 2 , and the average interparticle distance from their neighbours was about 8 nm. The current increased considerably up to the range of nanoamperes after the immobilization of the conjugated biphenyl molecules, 10 5 times larger than without molecules before immobilization. Although the Au nanoparticles can be connected to only 30% of all combinations of neighbouring Au nanoparticles by biphenyl molecules 2.4 nm long from the topological analysis, the biphenyl molecules can bridge most of the Au nanoparticles, and their bridging continuity is over 100 nm in length. Thus the measured current is suggested to come from the continuously bridged molecules between the Au nanoparticles. Furthermore the I-V data of the whole Au/SiO 2 nanocomposite film immobilized with conjugated molecules are confirmed to be in a reasonable range in comparison with the scanning tunnelling spectroscopy data of similar conjugated molecules
Pederzani, Jean-Noel; Haj-Hariri, Hossein
2012-11-01
An embedded-boundary (or cut-cell) method for complex geometry with moving boundaries is used to solve the three dimensional Navier-Stokes equation around a self-propelling manta swimming at moderately high Reynolds numbers. The motion of the ray is prescribed using a kinematic model fitted to actual biological data. The dependence of thrust production mechanism on Strouhal and Reynolds numbers is investigated. The vortex core structures are accurately plotted and a correlation between wake structures and propulsive performance is established. This insight is critical in understanding the key flow features that a bio-inspired autonomous vehicle should reproduce in order to swim efficiently. The solution method is implemented, on a block-structured Cartesian grid using a cut-cell approach enabling the code to correctly evaluate the wall shear-stress, a key feature necessary at higher Reynolds. To enhance computational efficiency, a parallel adaptive mesh refinement technique is used. The present method is validated against published experimental results. Supported by ONR MURI.
Grant, I R; Ball, H J; Rowe, M T
1998-02-01
The efficacy of high-temperature, short-time (HTST) pasteurization (72 degrees C/15 s) when low numbers (HTST pasteurization using laboratory pasteurizing units. Ten bovine strains of Myco. paratuberculosis were tested in triplicate. Culture in BACTEC Middlebrook 12B radiometric medium detected acid-fast survivors in 14.8% and 10% of HTST-pasteurized milk samples at the 10(3) and 10(2) cfu ml-1 inoculum levels, respectively, whereas conventional culture on Herrold's egg yolk medium containing mycobactin J detected acid-fast survivors in only 3.7% and 6.7% of the same milk samples. IS900-based PCR confirmed that these acid-fast survivors were Myco. paratuberculosis. No viable Myco. paratuberculosis were isolated from HTST-pasteurized milk initially containing either 10 cfu ml-1 or 10 cfu 50 ml-1.
Ian Roberts
2012-01-01
Full Text Available Reliable identification of copy number aberrations (CNA from comparative genomic hybridization data would be improved by the availability of a generalised method for processing large datasets. To this end, we developed swatCGH, a data analysis framework and region detection heuristic for computational grids. swatCGH analyses sequentially displaced (sliding windows of neighbouring probes and applies adaptive thresholds of varying stringency to identify the 10% of each chromosome that contains the most frequently occurring CNAs. We used the method to analyse a published dataset, comparing data preprocessed using four different DNA segmentation algorithms, and two methods for prioritising the detected CNAs. The consolidated list of the most commonly detected aberrations confirmed the value of swatCGH as a simplified high-throughput method for identifying biologically significant CNA regions of interest.
Tajuddin, A.A.; Chong, C.S.; Shukri, A.; Bradley, D.A.
1995-01-01
Mass attenuation coefficients for 12 selected moderate-to-high atomic-number elements have been obtained from good-geometry measurements made at five 241 Am photon energies of significant emission intensity. Particular interest focuses on measured values for photon energies close to absorption edges. Comparisons with renormalized cross-section predictions indicate agreement to within stated error limits for the majority of cases. Significant discrepancies (> 10%) are noted for Ta at 17.8 and 26.3 keV and W at 59.5 keV. Some support for a discrepancy between measurement and theory for W in the region of 60 keV is found in the reported measurements of others. (author)
Yano, T.; Nishino, K.; Kawamura, H.; Ueno, I.; Matsumoto, S.
2015-02-01
This paper reports the experimental results on the instability and associated roll structures (RSs) of Marangoni convection in liquid bridges formed under the microgravity environment on the International Space Station. The geometry of interest is high aspect ratio (AR = height/diameter ≥ 1.0) liquid bridges of high Prandtl number fluids (Pr = 67 and 207) suspended between coaxial disks heated differentially. The unsteady flow field and associated RSs were revealed with the three-dimensional particle tracking velocimetry. It is found that the flow field after the onset of instability exhibits oscillations with azimuthal mode number m = 1 and associated RSs traveling in the axial direction. The RSs travel in the same direction as the surface flow (co-flow direction) for 1.00 ≤ AR ≤ 1.25 while they travel in the opposite direction (counter-flow direction) for AR ≥ 1.50, thus showing the change of traveling directions with AR. This traveling direction for AR ≥ 1.50 is reversed to the co-flow direction when the temperature difference between the disks is increased to the condition far beyond the critical one. This change of traveling directions is accompanied by the increase of the oscillation frequency. The characteristics of the RSs for AR ≥ 1.50, such as the azimuthal mode of oscillation, the dimensionless oscillation frequency, and the traveling direction, are in reasonable agreement with those of the previous sounding rocket experiment for AR = 2.50 and those of the linear stability analysis of an infinite liquid bridge.
Ivana Stiperski
2017-01-01
Full Text Available In this article, we present an overview of the HyIV-CNRS-SecORo (Hydralab IV-CNRS-Secondary Orography and Rotors Experiments laboratory experiments carried out in the CNRM (Centre National de Recherches Météorologiques large stratified water flume. The experiments were designed to systematically study the influence of double obstacles on stably stratified flow. The experimental set-up consists of a two-layer flow in the water tank, with a lower neutral and an upper stable layer separated by a sharp density discontinuity. This type of layering over terrain is known to be conducive to a variety of possible responses in the atmosphere, from hydraulic jumps to lee waves and highly turbulent rotors. In each experiment, obstacles were towed through the tank at a constant speed. The towing speed and the size of the tank allowed high Reynolds-number flow similar to the atmosphere. Here, we present the experimental design, together with an overview of laboratory experiments conducted and their results. We develop a regime diagram for flow over single and double obstacles and examine the parameter space where the secondary obstacle has the largest influence on the flow. Trapped lee waves, rotors, hydraulic jumps, lee-wave interference and flushing of the valley atmosphere are successfully reproduced in the stratified water tank. Obstacle height and ridge separation distance are shown to control lee-wave interference. Results, however, differ partially from previous findings on the flow over double ridges reported in the literature due to the presence of nonlinearities and possible differences in the boundary layer structure. The secondary obstacle also influences the transition between different flow regimes and makes trapped lee waves possible for higher Froude numbers than expected for an isolated obstacle.
Gut, Małgorzata; Szumska, Izabela; Wasilewska, Marzena; Jaśkowski, Piotr
2012-07-01
In the brain, numbers are thought to be represented in a spatially organised fashion on what is known as the Mental Number Line (MNL). The SNARC (Spatial-Numerical Association of Response Codes) effect refers to the faster responses to digits when the reaction side is congruent with the digit position on the MNL (e.g. a left-handed response to a small magnitude) and the slowing down of responses (inhibition) in the case of incongruity. We examined the electrophysiological correlates of conflict, which are linked to that of inhibition, to shed light on the relationship between the SNARC effect and executive attention. Event-related potentials (ERPs) were recorded from twenty-nine participants during a parity-judgment task. The participants responded more quickly on congruent than on incongruent trials. The congruency effect was reflected in early sensory (N1, N2) components above parieto-occipital and frontal regions, as well as in the later P3 component above centro-parietal areas. Moreover, both the N1 amplitude and N2 latency were greater with high than low magnitude digit targets. P3 amplitude modulation implies that the SNARC effect is the result of first evoking the parallel processing of digit magnitude categorisation (in the occipital and central areas) and numeric conflict detection (in the parieto-occipital and frontal areas) and secondly conflict monitoring and resolution localised in the centro-parietal and frontal sites. These results also suggest that the left hemisphere specialises in conflict processing of high magnitude digit targets, while the right hemisphere of low digit magnitudes. Copyright © 2012 Elsevier B.V. All rights reserved.
X-ray emission from a high-atomic-number z-pinch plasma created from compact wire arrays
Sanford, T.W.L.; Mosher, D.; De Groot, J.S.
1996-01-01
Thermal and nonthermal x-ray emission from the implosion of compact tungsten wire arrays in 5-MA Saturn discharges is reported. The timing of multiple implosions and the thermal x-ray spectra (1 to 10 keV) agree with 2D radiation-hydrocode simulations. Nonthermal x-ray emission (10 to 100 keV) correlates with pinch spots distributed along the z-axis. The similarities of the measured nonthermal spectrum, yield, and pinch-spot emission with those of 0.8-MA, single-exploded-wire discharges on Gamble-II suggest a common nonthermal-production mechanism. Nonthermal x-ray yields are lower than expected from current scaling of Gamble II results, suggesting that implosion geometries are not as efficient as single-wire geometries for nonthermal x-ray production. The instabilities, azimuthal asymmetries, and inferred multiple implosions that accompany the implosion geometry lead to larger, more irregular pinch spots, a likely reason for reduced nonthermal efficiency. A model for nonthermal-electron acceleration across magnetic fields in highly-collisional, high-atomic-number plasmas combined with 1D hydrocode simulations of Saturn compact loads predicts weak nonthermal x-ray emission. (author). 3 figs., 10 refs
X-ray emission from a high-atomic-number z-pinch plasma created from compact wire arrays
Sanford, T.W.L.; Mosher, D.; De Groot, J.S.
1996-01-01
Thermal and nonthermal x-ray emission from the implosion of compact tungsten wire arrays in 5-MA Saturn discharges is reported. The timing of multiple implosions and the thermal x-ray spectra (1 to 10 keV) agree with 2D radiation-hydrocode simulations. Nonthermal x-ray emission (10 to 100 keV) correlates with pinch spots distributed along the z-axis. The similarities of the measured nonthermal spectrum, yield, and pinch-spot emission with those of 0.8-MA, single- exploded-wire discharges on Gamble-II suggest a common nonthermal- production mechanism. Nonthermal x-ray yields are lower than expected from current scaling of Gamble II results, suggesting that implosion geometries are not as efficient as single-wire geometries for nonthermal x-ray production. The instabilities, azimuthal asymmetries, and inferred multiple implosions that accompany the implosion geometry lead to larger, more irregular pinch spots, a likely reason for reduced nonthermal efficiency. A model for nonthermal-electron acceleration across magnetic fields in highly- collisional, high-atomic-number plasmas combined with 1D hydrocode simulations of Saturn compact loads predicts weak nonthermal x-ray emission
Prospathopoulos, John M; Papadakis, Giorgos; Voutsinas, Spyros G; Diakakis, Kostas; Sieros, Giorgos; Chaviaropoulos, Takis K
2014-01-01
The aerodynamic characteristics of thick airfoils in high Reynolds number is assessed using two different CFD RANS solvers: the compressible MaPFlow and the incompressible CRES-flowNS-2D both equipped with the k-ω SST turbulence model. Validation is carried out by comparing simulations against existing high Reynolds experimental data for the NACA 63-018 airfoil in the range of -10° to 20°. The use of two different solvers aims on one hand at increasing the credibility in the results and on the other at quantifying the compressibility effects. Convergence of steady simulations is achieved within a mean range of -10° to 14° which refers to attached or light stall conditions. Over this range the simulations from the two codes are in good agreement. As stall gets deeper, steady convergence ceases and the simulations must switch to unsteady. Lift and drag oscillations are produced which increase in amplitude as the angle of attack increases. Finally in post stall, the average C L is found to decrease up to ∼24° or 32° for the FFA or the NACA 63-018 airfoils respectively, and then recover to higher values indicating a change in the unsteady features of the flow
Shirish Shukla
2014-01-01
Full Text Available Background & objectives: High-risk human papilloma virus (HR-HPV infection and its integration in host genome is a key event in malignant transformation of cervical cells. HPV16 being a dominant HR-HPV type, we undertook this study to analyze if viral load and physical state of the virus correlated with each other in the absence of other confounding variables and examined their potential as predictors of progressive cervical lesions. Methods: Both, viral load and integration status of HPV16 were determined by real time URR PCR and estimation of E2:E6 ratio in a total of 130 PGMY-RLB -confirmed, monotypic HPV16-infected cervical DNA samples from biopsies of cytology-confirmed low grade (LSIL, 30 and high grade (HSIL, 30, and invasive carcinoma, (squamous cell carcinoma SCC, 70 cases. Results: Investigation of DNA samples revealed a gradual increase in HPV16 viral load over several magnitudes and increased frequency of integration from LSIL to HSIL and HSIL to invasive cancer in relation to the severity of lesions in monotypic HPV16-infected cervical tissues. In a substantial number of precancer (11/60 and cancer cases (29/70, HPV16 was detected in concomitant mixed form. The concomitant form of HPV16 genome carried significantly higher viral load. Interpretation & conclusions: Overall, viral load and integration increased with disease severity and could be useful biomarkers in disease progression, at least, in HPV16-infected cervical pre-cancer and cancer lesions.
Cicoria, David; Chan, C. K.
2017-07-01
Large eddy simulation (LES) is employed to investigate the effect of pressure on lean CH4-H2-air turbulent premixed flames at high Karlovitz number for mixtures up to 60% of hydrogen in volume. The subfilter combustion term representing the interaction between turbulence and chemistry is modelled using the PaSR model, along with complex chemistry using a skeletal mechanism based on GRI-MECH3.0. The influence of pressure at high turbulence levels is studied by means of the local flame structure, and the assessment of species formation inside the flame. Results show that the ratio of turbulent flame thickness to laminar flame thickness δt/δu increases faster with pressure, and increases with the fraction of hydrogen in the mixture, leading to higher ratio of turbulent to laminar flame speed. The flame displays smaller structures and higher degree of wrinkling at higher pressure. Final species of CO2 and H2O formation is almost independent of pressure. For intermediate species CO and OH, an increase in pressure at constant volume fraction of hydrogen β leads to a decrease of emission of these species.
Hata, K.; Fukuda, K.; Masuzaki, S.
2014-01-01
The subcooled boiling heat transfer and the steady state critical heat flux (CHF) in a vertical circular tube for the flow velocities (u=3.95 to 30.80 m/s) are systematically measured by the experimental water loop comprised of a multistage canned-type circulation pump with high pump head. The SUS304 test tube of inner diameter (d=6 mm) and heated length (L=59.5 mm) is used in this work. The outer surface temperatures of the SUS304 test tube with heating are observed by an infrared thermal imaging camera and a video camera. The subcooled boiling heat transfers for SUS304 test tube are compared with the values calculated by other workers' correlations for the subcooled boiling heat transfer. The influence of flow velocity on the subcooled boiling heat transfer and the CHF is investigated into details based on the experimental data. Nucleate boiling surface superheats at the CHF are close to the lower limit of the heterogeneous spontaneous nucleation temperature and the homogeneous spontaneous nucleation temperature. The dominant mechanism of the subcooled flow boiling CHF on the SUS304 circular tube is discussed at high liquid Reynolds number. On the other hand, theoretical equations for k-ε turbulence model in a circular tube of a 3 mm in diameter and a 526 mm long are numerically solved for heating of water on heated section of a 3 mm in diameter and a 67 mm long with various thicknesses of conductive sub-layer by using PHOENICS code under the same conditions as the experimental ones previously obtained considering the temperature dependence of thermo-physical properties concerned. The Platinum (Pt) test tube of inner diameter (d=3 mm) and heated length (L=66.5 mm) was used in this experiment. The thicknesses of conductive sub-layer from non-boiling regime to CHF are clarified. The thicknesses of conductive sub-layer at the CHF point are evaluated for various flow velocities. The experimental values of the CHF are also compared with the corresponding
Schaefer, Jennifer L.
2013-03-26
High lithium transference number, tLi+, electrolytes are desired for use in both lithium-ion and lithium metal rechargeable battery technologies. Historically, low tLi+ electrolytes have hindered device performance by allowing ion concentration gradients within the cell, leading to high internal resistances that ultimately limit cell lifetime, charging rates, and energy density. Herein, we report on the synthesis and electrochemical features of electrolytes based on nanoparticle salts designed to provide high tLi+. The salts are created by cofunctionalization of metal oxide nanoparticles with neutral organic ligands and tethered lithium salts. When dispersed in a conducting fluid such as tetraglyme, they spontaneously form a charged, nanoporous network of particles at moderate nanoparticle loadings. Modification of the tethered anion chemistry from -SO3 - to -SO3BF3 - is shown to enhance ionic conductivity of the electrolytes by facilitating ion pair dissociation. At a particle volume fraction of 0.15, the electrolyte exists as a self-supported, nanoporous gel with an optimum ionic conductivity of 10 -4 S/cm at room temperature. Galvanostatic polarization measurements on symmetric lithium metal cells containing the electrolyte show that the cell short circuit time, tSC, is inversely proportional to the square of the applied current density tSC ∼ J-2, consistent with previously predicted results for traditional polymer-in-salt electrolytes with low tLi+. Our findings suggest that electrolytes with tLi+ ≈ 1 and good ion-pair dissociation delay lithium dendrite nucleation and may lead to improved lithium plating in rechargeable batteries with metallic lithium anodes. © 2013 American Chemical Society.
Rodríguez, Ana Eugenia; Hernández, Jose Ángel; Benito, Rocío; Gutiérrez, Norma C.; García, Juan Luis; Hernández-Sánchez, María; Risueño, Alberto; Sarasquete, M. Eugenia; Fermiñán, Encarna; Fisac, Rosa; de Coca, Alfonso García; Martín-Núñez, Guillermo; de las Heras, Natalia; Recio, Isabel; Gutiérrez, Oliver; De Las Rivas, Javier; González, Marcos; Hernández-Rivas, Jesús M.
2012-01-01
Background Patients with chronic lymphocytic leukemia and 13q deletion as their only FISH abnormality could have a different outcome depending on the number of cells displaying this aberration. Thus, cases with a high number of 13q- cells (13q-H) had both shorter overall survival and time to first therapy. The goal of the study was to analyze the genetic profile of 13q-H patients. Design and Methods: A total of 102 samples were studied, 32 of which served as a validation cohort and five were healthy donors. Results Chronic lymphocytic leukemia patients with higher percentages of 13q- cells (>80%) showed a different level of gene expression as compared to patients with lower percentages (<80%, 13q-L). This deregulation affected genes involved in apoptosis and proliferation (BCR and NFkB signaling), leading to increased proliferation and decreased apoptosis in 13q-H patients. Deregulation of several microRNAs, such as miR-15a, miR-155, miR-29a and miR-223, was also observed in these patients. In addition, our study also suggests that the gene expression pattern of 13q-H cases could be similar to the patients with 11q- or 17p-. Conclusions This study provides new evidence regarding the heterogeneity of 13q deletion in chronic lymphocytic leukemia patients, showing that apoptosis, proliferation as well as miRNA regulation are involved in cases with higher percentages of 13q- cells. PMID:23152777
Seokhwi Kim
Full Text Available In the era of targeted therapy, mutation profiling of cancer is a crucial aspect of making therapeutic decisions. To characterize cancer at a molecular level, the use of formalin-fixed paraffin-embedded tissue is important. We tested the Ion AmpliSeq Cancer Hotspot Panel v2 and nCounter Copy Number Variation Assay in 89 formalin-fixed paraffin-embedded gastric cancer samples to determine whether they are applicable in archival clinical samples for personalized targeted therapies. We validated the results with Sanger sequencing, real-time quantitative PCR, fluorescence in situ hybridization and immunohistochemistry. Frequently detected somatic mutations included TP53 (28.17%, APC (10.1%, PIK3CA (5.6%, KRAS (4.5%, SMO (3.4%, STK11 (3.4%, CDKN2A (3.4% and SMAD4 (3.4%. Amplifications of HER2, CCNE1, MYC, KRAS and EGFR genes were observed in 8 (8.9%, 4 (4.5%, 2 (2.2%, 1 (1.1% and 1 (1.1% cases, respectively. In the cases with amplification, fluorescence in situ hybridization for HER2 verified gene amplification and immunohistochemistry for HER2, EGFR and CCNE1 verified the overexpression of proteins in tumor cells. In conclusion, we successfully performed semiconductor-based sequencing and nCounter copy number variation analyses in formalin-fixed paraffin-embedded gastric cancer samples. High-throughput screening in archival clinical samples enables faster, more accurate and cost-effective detection of hotspot mutations or amplification in genes.
Abbas, M., E-mail: micheline.abbas@ensiacet.fr [Laboratoire de Génie Chimique, Université de Toulouse INPT-UPS, 31030, Toulouse (France); CNRS, Fédération de recherche FERMaT, CNRS, 31400, Toulouse (France); Magaud, P. [CNRS, Fédération de recherche FERMaT, CNRS, 31400, Toulouse (France); Institut Clément Ader, Université de Toulouse UPS-INSA-ISAE-Mines Albi, 31400, Toulouse (France); Gao, Y. [Institut Clément Ader, Université de Toulouse UPS-INSA-ISAE-Mines Albi, 31400, Toulouse (France); Geoffroy, S. [CNRS, Fédération de recherche FERMaT, CNRS, 31400, Toulouse (France); Laboratoire Matériaux et Durabilité des Constructions, Université de Toulouse (France); UPS, INSA, 31077, Toulouse (France)
2014-12-15
The migration of neutrally buoyant finite sized particles in a Newtonian square channel flow is investigated in the limit of very low solid volumetric concentration, within a wide range of channel Reynolds numbers Re = [0.07-120]. In situ microscope measurements of particle distributions, taken far from the channel inlet (at a distance several thousand times the channel height), revealed that particles are preferentially located near the channel walls at Re > 10 and near the channel center at Re < 1. Whereas the cross-streamline particle motion is governed by inertia-induced lift forces at high inertia, it seems to be controlled by shear-induced particle interactions at low (but finite) Reynolds numbers, despite the low solid volume fraction (<1%). The transition between both regimes is observed in the range Re = [1-10]. In order to exclude the effect of multi-body interactions, the trajectories of single freely moving particles are calculated thanks to numerical simulations based on the force coupling method. With the deployed numerical tool, the complete particle trajectories are accessible within a reasonable computational time only in the inertial regime (Re > 10). In this regime, we show that (i) the particle undergoes cross-streamline migration followed by a cross-lateral migration (parallel to the wall) in agreement with previous observations, and (ii) the stable equilibrium positions are located at the midline of the channel faces while the diagonal equilibrium positions are unstable. At low flow inertia, the first instants of the numerical simulations (carried at Re = O(1)) reveal that the cross-streamline migration of a single particle is oriented towards the channel wall, suggesting that the particle preferential positions around the channel center, observed in the experiments, are rather due to multi-body interactions.
Abbas, M.; Magaud, P.; Gao, Y.; Geoffroy, S.
2014-01-01
The migration of neutrally buoyant finite sized particles in a Newtonian square channel flow is investigated in the limit of very low solid volumetric concentration, within a wide range of channel Reynolds numbers Re = [0.07-120]. In situ microscope measurements of particle distributions, taken far from the channel inlet (at a distance several thousand times the channel height), revealed that particles are preferentially located near the channel walls at Re > 10 and near the channel center at Re < 1. Whereas the cross-streamline particle motion is governed by inertia-induced lift forces at high inertia, it seems to be controlled by shear-induced particle interactions at low (but finite) Reynolds numbers, despite the low solid volume fraction (<1%). The transition between both regimes is observed in the range Re = [1-10]. In order to exclude the effect of multi-body interactions, the trajectories of single freely moving particles are calculated thanks to numerical simulations based on the force coupling method. With the deployed numerical tool, the complete particle trajectories are accessible within a reasonable computational time only in the inertial regime (Re > 10). In this regime, we show that (i) the particle undergoes cross-streamline migration followed by a cross-lateral migration (parallel to the wall) in agreement with previous observations, and (ii) the stable equilibrium positions are located at the midline of the channel faces while the diagonal equilibrium positions are unstable. At low flow inertia, the first instants of the numerical simulations (carried at Re = O(1)) reveal that the cross-streamline migration of a single particle is oriented towards the channel wall, suggesting that the particle preferential positions around the channel center, observed in the experiments, are rather due to multi-body interactions
Garcia-Fernàndez, J; Bayascas-Ramírez, J R; Marfany, G; Muñoz-Mármol, A M; Casali, A; Baguñà, J; Saló, E
1995-05-01
Several DNA sequences similar to the mariner element were isolated and characterized in the platyhelminthe Dugesia (Girardia) tigrina. They were 1,288 bp long, flanked by two 32 bp-inverted repeats, and contained a single 339 amino acid open-reading frame (ORF) encoding the transposase. The number of copies of this element is approximately 8,000 per haploid genome, constituting a member of the middle-repetitive DNA of Dugesia tigrina. Sequence analysis of several elements showed a high percentage of conservation between the different copies. Most of them presented an intact ORF and the standard signals of actively expressed genes, which suggests that some of them are or have recently been functional transposons. The high degree of similarity shared with other mariner elements from some arthropods, together with the fact that this element is undetectable in other planarian species, strongly suggests a case of horizontal transfer between these two distant phyla.
Computational analysis of locally forced flow over a wall-mounted hump at high-Re number
Saric, S.; Jakirlic, S.; Djugum, A.; Tropea, C.
2006-01-01
An incompressible, high-Reynolds number flow (slightly less then 1 Mio. per chord) over a smoothly contoured, asymmetric, wall-mounted hump was computationally studied using the LES (large eddy simulation) and DES (detached eddy simulation) methods. In addition, several second-moment and eddy-viscosity closures within the RANS (Reynolds-averaged Navier-Stokes) framework were tested. The focus of the investigation was on the effects of local perturbation of the hump boundary layer introduced by spatially uniform (in the spanwise direction) steady suction and oscillatory suction/blowing through a narrow opening (1.7 mm) situated at the hump crest immediately upstream of the natural separation point. Reference experiments have shown that both flow control mechanisms cause a shortening of the recirculation bubble relative to the baseline configuration with no flow control. All statistical turbulence models used in the RANS framework resulted in a substantially larger recirculation zone independent of the modelling level, being a consequence of a too low turbulence level in the separated shear layer. Accordingly, the effect of the steady suction, namely the reduction of the reattachment length, was underpredicted. The LES method, despite a relatively coarse mesh (with a total of 4 Mio. cells) for such a high-Reynolds number, wall-bounded flow, was capable of capturing important effects of the flow control qualitatively and quantitatively. DES failed to do so in the suction case, despite good results in the baseline and oscillatory blowing/suction cases, indicating that a shallow separation from curved surfaces poses a challenge to this hybrid RANS/LES strategy. A sensitivity study of the RANS/LES interface position within the DES approach shows that a RANS region chosen too thin (with the interface situated at the very beginning of the logarithmic layer) can lead to a strong reduction of the turbulent viscosity causing a low turbulence level within the shear layer
X-ray emission from a high-atomic-number z-pinch plasma created from compact wire arrays
Sanford, T.W.L.; Nash, T.J.; Marder, B.M.
1996-03-01
Thermal and nonthermal x-ray emission from the implosion of compact tungsten wire arrays, driven by 5 MA from the Saturn accelerator, are measured and compared with LLNL Radiation-Hydro-Code (RHC) and SNL Hydro-Code (HC) numerical models. Multiple implosions, due to sequential compressions and expansions of the plasma, are inferred from the measured multiple x-radiation bursts. Timing of the multiple implosions and the thermal x-ray spectra measured between 1 and 10 keV are consistent with the RHC simulations. The magnitude of the nonthermal x-ray emission measured from 10 to 100 keV ranges from 0.02 to 0.08% of the total energy radiated and is correlated with bright-spot emission along the z-axis, as observed in earlier Gamble-11 single exploding-wire experiments. The similarities of the measured nonthermal spectrum and bright-spot emission with those measured at 0.8 MA on Gamble-II suggest a common production mechanism for this process. A model of electron acceleration across magnetic fields in highly-collisional, high-atomic-number plasmas is developed, which shows the existence of a critical electric field, E c , below which strong nonthermal electron creation (and the associated nonthermal x rays) do not occur. HC simulations show that significant nonthermal electrons are not expected in this experiment (as observed) because the calculated electric fields are at least one to two orders-of-magnitude below E c . These negative nonthermal results are confirmed by RHC simulations using a nonthermal model based on a Fokker-Plank analysis. Lastly, the lower production efficiency and the larger, more irregular pinch spots formed in this experiment relative to those measured on Gamble II suggest that implosion geometries are not as efficient as single exploding-wire geometries for warm x-ray production
Hu, Xin-Sheng; Yeh, Francis C; Hu, Yang; Deng, Li-Ting; Ennos, Richard A; Chen, Xiaoyang
2017-02-22
Copy-number-variable (CNV) loci differ from single nucleotide polymorphic (SNP) sites in size, mutation rate, and mechanisms of maintenance in natural populations. It is therefore hypothesized that population genetic divergence at CNV loci will differ from that found at SNP sites. Here, we test this hypothesis by analysing 856 CNV loci from the genomes of 1184 healthy individuals from 11 HapMap populations with a wide range of ancestry. The results show that population genetic divergence at the CNV loci is generally more than three times lower than at genome-wide SNP sites. Populations generally exhibit very small genetic divergence (G st = 0.05 ± 0.049). The smallest divergence is among African populations (G st = 0.0081 ± 0.0025), with increased divergence among non-African populations (G st = 0.0217 ± 0.0109) and then among African and non-African populations (G st = 0.0324 ± 0.0064). Genetic diversity is high in African populations (~0.13), low in Asian populations (~0.11), and intermediate in the remaining 11 populations. Few significant linkage disequilibria (LDs) occur between the genome-wide CNV loci. Patterns of gametic and zygotic LDs indicate the absence of epistasis among CNV loci. Mutation rate is about twice as large as the migration rate in the non-African populations, suggesting that the high mutation rates play dominant roles in producing the low population genetic divergence at CNV loci.
Asaithamby, Aroumougame, E-mail: Aroumougame.Asaithamy@UTsouthwestern.edu [Division of Molecular Radiation Biology, Department of Radiation Oncology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 (United States); Chen, David J., E-mail: David.Chen@UTsouthwestern.edu [Division of Molecular Radiation Biology, Department of Radiation Oncology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 (United States)
2011-06-03
Low-linear energy transfer (LET) radiation (i.e., {gamma}- and X-rays) induces DNA double-strand breaks (DSBs) that are rapidly repaired (rejoined). In contrast, DNA damage induced by the dense ionizing track of high-atomic number and energy (HZE) particles is slowly repaired or is irreparable. These unrepaired and/or misrepaired DNA lesions may contribute to the observed higher relative biological effectiveness for cell killing, chromosomal aberrations, mutagenesis, and carcinogenesis in HZE particle irradiated cells compared to those treated with low-LET radiation. The types of DNA lesions induced by HZE particles have been characterized in vitro and usually consist of two or more closely spaced strand breaks, abasic sites, or oxidized bases on opposing strands. It is unclear why these lesions are difficult to repair. In this review, we highlight the potential of a new technology allowing direct visualization of different types of DNA lesions in human cells and document the emerging significance of live-cell imaging for elucidation of the spatio-temporal characterization of complex DNA damage. We focus on the recent insights into the molecular pathways that participate in the repair of HZE particle-induced DSBs. We also discuss recent advances in our understanding of how different end-processing nucleases aid in repair of DSBs with complicated ends generated by HZE particles. Understanding the mechanism underlying the repair of DNA damage induced by HZE particles will have important implications for estimating the risks to human health associated with HZE particle exposure.
Asaithamby, Aroumougame; Chen, David J.
2011-01-01
Low-linear energy transfer (LET) radiation (i.e., γ- and X-rays) induces DNA double-strand breaks (DSBs) that are rapidly repaired (rejoined). In contrast, DNA damage induced by the dense ionizing track of high-atomic number and energy (HZE) particles is slowly repaired or is irreparable. These unrepaired and/or misrepaired DNA lesions may contribute to the observed higher relative biological effectiveness for cell killing, chromosomal aberrations, mutagenesis, and carcinogenesis in HZE particle irradiated cells compared to those treated with low-LET radiation. The types of DNA lesions induced by HZE particles have been characterized in vitro and usually consist of two or more closely spaced strand breaks, abasic sites, or oxidized bases on opposing strands. It is unclear why these lesions are difficult to repair. In this review, we highlight the potential of a new technology allowing direct visualization of different types of DNA lesions in human cells and document the emerging significance of live-cell imaging for elucidation of the spatio-temporal characterization of complex DNA damage. We focus on the recent insights into the molecular pathways that participate in the repair of HZE particle-induced DSBs. We also discuss recent advances in our understanding of how different end-processing nucleases aid in repair of DSBs with complicated ends generated by HZE particles. Understanding the mechanism underlying the repair of DNA damage induced by HZE particles will have important implications for estimating the risks to human health associated with HZE particle exposure.
Yano, Taishi; Nishino, Koichi; Matsumoto, Satoshi; Ueno, Ichiro; Komiya, Atsuki; Kamotani, Yasuhiro; Imaishi, Nobuyuki
2018-04-01
This paper reports an overview and some important results of microgravity experiments called Dynamic Surf, which have been conducted on board the International Space Station from 2013 to 2016. The present project mainly focuses on the relations between the Marangoni instability in a high-Prandtl-number (Pr= 67 and 112) liquid bridge and the dynamic free surface deformation (DSD) as well as the interfacial heat transfer. The dynamic free surface deformations of large-scale liquid bridges (say, for diameters greater than 10 mm) are measured with good accuracy by an optical imaging technique. It is found that there are two causes of the dynamic free surface deformation in the present study: the first is the time-dependent flow behavior inside the liquid bridge due to the Marangoni instability, and the second is the external disturbance due to the residual acceleration of gravity, i.e., g-jitter. The axial distributions of DSD along the free surface are measured for several conditions. The critical parameters for the onset of oscillatory Marangoni convection are also measured for various aspect ratios (i.e., relative height to the diameter) of the liquid bridge and various thermal boundary conditions. The characteristics of DSD and the onset conditions of instability are discussed in this paper.
Elbing, Brian; Perlin, Marc; Dowling, David; Solomon, Michael; Ceccio, Steven
2008-11-01
Two experiments were conducted to investigate polymer drag reduction (PDR) within high Reynolds number (to 200 million based on downstream distance), rough-wall turbulent boundary layers. The first experiment was conducted at the U.S. Navy's Large Cavitation Channel on a 12.9 m long flat-plate at speeds to 20 m/s with the surface hydraulically smooth and fully rough. Local skin-friction measurements on the smooth and rough surfaces had maximum PDR levels of 65 and 75 percent, respectively. However, PDR decreased with increasing downstream distance and flow speed more rapidly on the rough surface, and at the top speed no measureable level of PDR was observed. The roughness-induced increased diffusion was quantified with near-wall concentration measurements and the second experiment, which measured concentration profiles on a 0.94 m long flat-plate with three surface conditions: smooth, 240-grit, and 60-grit sandpaper. The increased diffusion does not fully explain the smooth-rough PDR differences observed in the first experiment. Rheological analysis of drawn samples from the first experiment indicates that polymer degradation (chain scission) could be responsible for the remaining loss of rough-wall PDR. These results have implications for the cost effectiveness of PDR for surface ships.
Elbing, Brian; Dowling, David; Solomon, Michael; Bian, Sherry; Ceccio, Steven
2007-11-01
A recent experiment at the U.S. Navy's Large Cavitation Channel (LCC) investigated the effect of wall roughness on wall-injection polymer drag reduction (PDR) within a high-Reynolds-number (10^7 to 2x10^8 based on downstream distance) turbulent boundary layer (TBL). Testing was performed in two parts: 1) PDR experiment on a 12.9 m long, 3.05 m wide hydro-dynamically smooth flat plate and 2) PDR experiment on the same model with the entire surface roughened. The roughness was produced by blowing glass beads into epoxy paint that was applied to the entire model. The roughened model had an average roughness height ranging between 307 and 1154 μm. Drag reduction was determined using six, stream-wise located integrated skin-friction balances. In addition to skin-friction measurements, sampling was performed at three stream-wise located ports. The sampling ports were used to determine the amount of degradation, if any, caused by the turbulent flow on the polymer. Both the skin-friction measurements and sampling analysis indicates that wall roughness in a turbulent boundary layer significantly increases degradation of the polymer solution.
Mindaugas Liogys
2013-08-01
Full Text Available Purpose—is to investigate a shift sequence-based approach efficiency then problem consisting of a high number of shifts.Research objectives:• Solve health care workers rostering problem using a shift sequence based method.• Measure its efficiency then number of shifts increases.Design/methodology/approach—Usually rostering problems are highly constrained. Constraints are classified to soft and hard constraints. Soft and hard constraints of the problem are additionally classified to: sequence constraints, schedule constraints and roster constraints. Sequence constraints are considered when constructing shift sequences. Schedule constraints are considered when constructing a schedule. Roster constraints are applied, then constructing overall solution, i.e. combining all schedules.Shift sequence based approach consists of two stages:• Shift sequences construction,• The construction of schedules.In the shift sequences construction stage, the shift sequences are constructed for each set of health care workers of different skill, considering sequence constraints. Shifts sequences are ranked by their penalties for easier retrieval in later stage.In schedules construction stage, schedules for each health care worker are constructed iteratively, using the shift sequences produced in stage 1.Shift sequence based method is an adaptive iterative method where health care workers who received the highest schedule penalties in the last iteration are scheduled first at the current iteration.During the roster construction, and after a schedule has been generated for the current health care worker, an improvement method based on an efficient greedy local search is carried out on the partial roster. It simply swaps any pair of shifts between two health care workers in the (partial roster, as long as the swaps satisfy hard constraints and decrease the roster penalty.Findings—Using shift sequence method for solving health care workers rostering problem
Mindaugas Liogys
2011-08-01
Full Text Available Purpose—is to investigate a shift sequence-based approach efficiency then problem consisting of a high number of shifts. Research objectives:• Solve health care workers rostering problem using a shift sequence based method.• Measure its efficiency then number of shifts increases. Design/methodology/approach—Usually rostering problems are highly constrained.Constraints are classified to soft and hard constraints. Soft and hard constraints of the problem are additionally classified to: sequence constraints, schedule constraints and roster constraints. Sequence constraints are considered when constructing shift sequences. Schedule constraints are considered when constructing a schedule. Roster constraints are applied, then constructing overall solution, i.e. combining all schedules.Shift sequence based approach consists of two stages:• Shift sequences construction,• The construction of schedules.In the shift sequences construction stage, the shift sequences are constructed for each set of health care workers of different skill, considering sequence constraints. Shifts sequences are ranked by their penalties for easier retrieval in later stage.In schedules construction stage, schedules for each health care worker are constructed iteratively, using the shift sequences produced in stage 1. Shift sequence based method is an adaptive iterative method where health care workers who received the highest schedule penalties in the last iteration are scheduled first at the current iteration. During the roster construction, and after a schedule has been generated for the current health care worker, an improvement method based on an efficient greedy local search is carried out on the partial roster. It simply swaps any pair of shifts between two health care workers in the (partial roster, as long as the swaps satisfy hard constraints and decrease the roster penalty.Findings—Using shift sequence method for solving health care workers rostering
Re, Richard J.
2005-01-01
Force balance and wing pressure data were obtained on a 0.017-Scale Model of a blended-wing-body configuration (without a simulated propulsion system installation) to validate the capability of computational fluid dynamic codes to predict the performance of such thick sectioned subsonic transport configurations. The tests were conducted in the National Transonic Facility of the Langley Research Center at Reynolds numbers from 3.5 to 25.0 million at Mach numbers from 0.25 to 0.86. Data were obtained in the pitch plane only at angles of attack from -1 to 8 deg at Mach numbers greater than 0.25. A configuration with winglets was tested at a Reynolds number of 25.0 million at Mach numbers from 0.83 to 0.86.
Maggiore, M.; Shifman, M.
1993-01-01
We critically discuss recent works in which the premature unitarization mechanism is studied with the inclusion of non-nearest-neighbor interactions or beyond leading order in the energy. We also point out that the nonperturbative valley method gives inconsistent results when applied to fermion-number-violating amplitudes, and we argue that, independently of the mechanism of premature unitarization, the nonperturbative amplitudes which violate the fermion number are always exponentially suppressed
Clay, M. P.; Buaria, D.; Gotoh, T.; Yeung, P. K.
2017-10-01
A new dual-communicator algorithm with very favorable performance characteristics has been developed for direct numerical simulation (DNS) of turbulent mixing of a passive scalar governed by an advection-diffusion equation. We focus on the regime of high Schmidt number (S c), where because of low molecular diffusivity the grid-resolution requirements for the scalar field are stricter than those for the velocity field by a factor √{ S c }. Computational throughput is improved by simulating the velocity field on a coarse grid of Nv3 points with a Fourier pseudo-spectral (FPS) method, while the passive scalar is simulated on a fine grid of Nθ3 points with a combined compact finite difference (CCD) scheme which computes first and second derivatives at eighth-order accuracy. A static three-dimensional domain decomposition and a parallel solution algorithm for the CCD scheme are used to avoid the heavy communication cost of memory transposes. A kernel is used to evaluate several approaches to optimize the performance of the CCD routines, which account for 60% of the overall simulation cost. On the petascale supercomputer Blue Waters at the University of Illinois, Urbana-Champaign, scalability is improved substantially with a hybrid MPI-OpenMP approach in which a dedicated thread per NUMA domain overlaps communication calls with computational tasks performed by a separate team of threads spawned using OpenMP nested parallelism. At a target production problem size of 81923 (0.5 trillion) grid points on 262,144 cores, CCD timings are reduced by 34% compared to a pure-MPI implementation. Timings for 163843 (4 trillion) grid points on 524,288 cores encouragingly maintain scalability greater than 90%, although the wall clock time is too high for production runs at this size. Performance monitoring with CrayPat for problem sizes up to 40963 shows that the CCD routines can achieve nearly 6% of the peak flop rate. The new DNS code is built upon two existing FPS and CCD codes
Metzger, M.
2006-01-01
Reynolds number effects on relevant length and time scales in the near-wall region of a canonical turbulent boundary layer are investigated. Well resolved measurements in the atmospheric surface layer are compared with existing laboratory data to give a composite Reynolds number range spanning over three orders of magnitude. In the field experiments, a vertical rake of twenty single element hot-wires was used to measure the axial velocity, u, characteristics in the lower log layer region of the atmospheric surface layer that flows over Utah's western desert. Only data acquired under conditions of near-neutral thermal stability are analyzed. The shape of the power spectra of u as a function of distance from the wall, y, and Reynolds number is investigated, with emphasis on the appropriate scaling parameters valid across different wavenumber, k, bands. In particular, distance from the wall is found to scale the region of the u spectra around ky = 1. The presence of a k -1 slope in the spectra is also found to correlate with the Reynolds number dependence in the peak of the root mean square u profile. In addition, Reynolds number trends in the profiles of the Taylor microscales, which represent intermediate length and time scales in the boundary layer, are shown to deviate from classical scaling
Bennett, Ruth, Ed.; And Others
An introduction to the Hupa number system is provided in this workbook, one in a series of numerous materials developed to promote the use of the Hupa language. The book is written in English with Hupa terms used only for the names of numbers. The opening pages present the numbers from 1-10, giving the numeral, the Hupa word, the English word, and…
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Triangular number, figurate num- ber, rangoli, Brahmagupta–Pell equation, Jacobi triple product identity. Figure 1. The first four triangular numbers. Left: Anuradha S Garge completed her PhD from. Pune University in 2008 under the supervision of Prof. S A Katre. Her research interests include K-theory and number theory.
Schwarzweller Christoph
2015-02-01
Full Text Available In this article we introduce Proth numbers and prove two theorems on such numbers being prime [3]. We also give revised versions of Pocklington’s theorem and of the Legendre symbol. Finally, we prove Pepin’s theorem and that the fifth Fermat number is not prime.
Jackson, J.D.
2011-01-01
of the buoyancy-influenced region across the shear layer. Buoyancy affects the mean motion, aiding it in the case of upward flow and opposing it in the case of downward flow. Thus, in the case of buoyancy-aided flow advection of heat is increased and for buoyancy-opposed flow it is reduced. Buoyancy also has the effect of modifying the distribution of shear stress across a wall shear flow which affects the production of turbulence, reducing it with onset of buoyancy influence for upward flow and impairing heat transfer by diffusion. This trend eventually changes with further increase of buoyancy influence. For downward flow, turbulence production and turbulent heat transfer are systematically enhanced with increase of buoyancy influence. In turbulent flow at sufficiently high Peclet number (turbulent flow of fluids with Prandtl numbers of about unity and above), the diffusion of heat by turbulence is of dominant importance and so the effects of buoyancy on heat transfer are as just indicated. However in the case of fluids having Prandtl numbers very much less than unity (where the Peclet number is smaller), diffusion of heat by turbulence is of secondary importance and so, even if buoyancy has had a significant effect on the turbulence in the flow, its effect on heat transfer is no longer dominant. So, enhancement of heat transfer occurs with upward flow due to the increased advection and impairment occurs with downward flow. These simple physical ideas enable the seemingly anomalous heat transfer behavior in the case of fluids having very low Prandtl number to be reconciled with the completely different behavior of fluids with higher Prandtl number. The main objective of this paper is to illustrate these ideas with reference to a selection of experimental data and to discuss them. The data used to do this was mostly produced by the author, his colleagues and students. Some of investigations are not widely known about. So, this paper should be helpful to those who
Mendonça, J. Ricardo G.
2012-01-01
We define a new class of numbers based on the first occurrence of certain patterns of zeros and ones in the expansion of irracional numbers in a given basis and call them Sagan numbers, since they were first mentioned, in a special case, by the North-american astronomer Carl E. Sagan in his science-fiction novel "Contact." Sagan numbers hold connections with a wealth of mathematical ideas. We describe some properties of the newly defined numbers and indicate directions for further amusement.
Edwards, Katie M.; Eckstein, Robert P.; Rodenhizer-Stämpfli , Kara Anne
2015-01-01
Using data from a sample of 218 high school youth from three high schools in New England (one rural, two urban), this brief discusses dating and sexual aggression bystander intervention among high school youth. Authors Katie Edwards, Robert Eckstein, and Kara Anne Rodenhizer-Stämpfli report that an overwhelming majority (93.6 percent) of high…
Rahimi, A. B.
2003-01-01
Although there are many papers on the subject of heat transfer in an axisymmetric stagnation flow on a cylinder, the available knowledge is mainly for low Reynolds numbers and not much information exists for the same problem at large Reynolds numbers. In this work, the problem of heat transfer in an axisymmetric stagnation flow on a cylinder is solved at large Reynolds numbers using perturbation techniques. Starting from Navier-Stokes equations within a boundary layer approximation and using similarity transformations, the governing equations are obtained in the form of differential equations. The inverse of the Reynolds number is introduced as the perturbation parameter. This parameter appears in front of the highest-order terms and, as it tends to zero, reduces the order of the governing equations and produces singularities. In this paper, the flow field is divided into two regions; rapid changes in the region near wall and slow changes away from the wall. Thus, the flow is found to have dual-layer characteristics. Using inner and outer expansion produces uniform values of the relevant quantities
Petersen, T Kyle
2015-01-01
This text presents the Eulerian numbers in the context of modern enumerative, algebraic, and geometric combinatorics. The book first studies Eulerian numbers from a purely combinatorial point of view, then embarks on a tour of how these numbers arise in the study of hyperplane arrangements, polytopes, and simplicial complexes. Some topics include a thorough discussion of gamma-nonnegativity and real-rootedness for Eulerian polynomials, as well as the weak order and the shard intersection order of the symmetric group. The book also includes a parallel story of Catalan combinatorics, wherein the Eulerian numbers are replaced with Narayana numbers. Again there is a progression from combinatorics to geometry, including discussion of the associahedron and the lattice of noncrossing partitions. The final chapters discuss how both the Eulerian and Narayana numbers have analogues in any finite Coxeter group, with many of the same enumerative and geometric properties. There are four supplemental chapters throughout, ...
Puragliesi, R.; Dehbi, A.; Leriche, E.; Soldati, A.; Deville, M.O.
2011-01-01
Highlights: → 2D study of micro-size particle depletion driven by chaotic natural convective flows in square domains. → Description of velocity and temperature first and second moments with changing in the Rayleigh number. → Strong decoupling between the turbulent kinetic energy and the dissipation rate. → Particle recirculation sustained by the vertical hot boundary layer. → Deposition mostly induced by gravity, thermophoretic and lift forces are negligible. - Abstract: In this work we investigate numerically particle deposition in the buoyancy driven flow of the differentially heated cavity (DHC). We consider two values of the Rayleigh number (Ra = 10 9 , 10 10 ) and three values of the particle diameter (d p = 15, 25, 35 [μm]). We consider the cavity filled with air and particles with the same density of water ρ w = 1000 [kg/m 3 ] (aerosol). We use direct numerical simulations (DNS) for the continuous phase, and we solve transient Navier-Stokes and energy transport equations written in an Eulerian framework, under the Boussinesq approximation, for the viscous incompressible Newtonian fluid with constant Prandtl number (Pr = 0.71). First- and second-order statistics are presented for the continuous phase as well as important quantities like turbulent kinetic energy (TKE) and temperature variance with the associated production and dissipation fields. The TKE production shows different behaviour at the two Rayleigh numbers. The Lagrangian approach has been chosen for the dispersed phase description. The forces taken into account are drag, gravity, buoyancy, lift and thermophoresis. A first incursion in the sedimentation mechanisms is presented. Current results indicate that the largest contribution to particle deposition is caused by gravitational settling, but a strong recirculating zone, which liftoffs and segregates particles, contributes to decrease settling. Deposition takes place mostly at the bottom wall. The influence of lift and thermophoretic
Puragliesi, R., E-mail: riccardo.puragliesi@psi.ch [Nuclear Energy and Safety Research Department, Paul Scherrer Institut, CH-5232 Villigen PSI (Switzerland); Laboratoire d' Ingenierie Numerique, Ecole Polytechnique Federale de Lausanne, Station 9, CH-1015 Lausanne (Switzerland); Dehbi, A., E-mail: abdel.dehbi@psi.ch [Nuclear Energy and Safety Research Department, Paul Scherrer Institut, CH-5232 Villigen PSI (Switzerland); Leriche, E., E-mail: emmanuel.leriche@univ-st-etienne.fr [Universite de Lyon, F-42023 Saint-Etienne, LMFA-UJM St-Etienne, CNRS UMR 5509 Universite de St-Etienne, 23 rue Docteur Paul Michelon, F-42023 Saint-Etienne (France); Soldati, A., E-mail: soldati@uniud.it [Dipartimento di Energetica e Macchine, Universita di Udine, Via delle Scienze 208, IT-33100 Udine (Italy); Deville, M.O., E-mail: michel.deville@epfl.ch [Laboratoire d' Ingenierie Numerique, Ecole Polytechnique Federale de Lausanne, Station 9, CH-1015 Lausanne (Switzerland)
2011-10-15
Highlights: > 2D study of micro-size particle depletion driven by chaotic natural convective flows in square domains. > Description of velocity and temperature first and second moments with changing in the Rayleigh number. > Strong decoupling between the turbulent kinetic energy and the dissipation rate. > Particle recirculation sustained by the vertical hot boundary layer. > Deposition mostly induced by gravity, thermophoretic and lift forces are negligible. - Abstract: In this work we investigate numerically particle deposition in the buoyancy driven flow of the differentially heated cavity (DHC). We consider two values of the Rayleigh number (Ra = 10{sup 9}, 10{sup 10}) and three values of the particle diameter (d{sub p} = 15, 25, 35 [{mu}m]). We consider the cavity filled with air and particles with the same density of water {rho}{sub w} = 1000 [kg/m{sup 3}] (aerosol). We use direct numerical simulations (DNS) for the continuous phase, and we solve transient Navier-Stokes and energy transport equations written in an Eulerian framework, under the Boussinesq approximation, for the viscous incompressible Newtonian fluid with constant Prandtl number (Pr = 0.71). First- and second-order statistics are presented for the continuous phase as well as important quantities like turbulent kinetic energy (TKE) and temperature variance with the associated production and dissipation fields. The TKE production shows different behaviour at the two Rayleigh numbers. The Lagrangian approach has been chosen for the dispersed phase description. The forces taken into account are drag, gravity, buoyancy, lift and thermophoresis. A first incursion in the sedimentation mechanisms is presented. Current results indicate that the largest contribution to particle deposition is caused by gravitational settling, but a strong recirculating zone, which liftoffs and segregates particles, contributes to decrease settling. Deposition takes place mostly at the bottom wall. The influence of lift
Jones, V.D.
1997-01-01
High Level Radioactive Waste Tanks at the Savannah River Site are high in salt content. The cross-flow nebulizer provided the most stable signal for all salt matrices with the smallest signal loss/suppression due to this matrix. The DIN exhibited a serious lack of tolerance for TDS; possibly due to physical de-tuning of the nebulizer efficiency
Cooperstein, G; Mosher, D; Stephanakis, S J; Weber, B V; Young, F C [Naval Research Laboratory, Washington, DC (United States); Swanekamp, S B [JAYCOR, Vienna, VA (United States)
1997-12-31
Backscattered electrons from anodes with high-atomic-number substrates cause early-time anode-plasma formation from the surface layer leading to faster, more intense electron beam pinching, and lower diode impedance. A simple derivation of Child-Langmuir current from a thin hollow cathode shows the same dependence on the diode aspect ratio as critical current. Using this fact, it is shown that the diode voltage and current follow relativistic Child-Langmuir theory until the anode plasma is formed, and then follows critical current after the beam pinches. With thin hollow cathodes, electron beam pinching can be suppressed at low voltages (< 800 kV) even for high currents and high-atomic-number anodes. Electron beam pinching can also be suppressed at high voltages for low-atomic-number anodes as long as the electron current densities remain below the plasma turn-on threshold. (author). 8 figs., 2 refs.
Transfinite Numbers. What is Infinity? S M Srivastava. In a series of revolutionary articles written during the last quarter of the nineteenth century, the great Ger- man mathematician Georg Cantor removed the age-old mistrust of infinity and created an exceptionally beau- tiful and useful theory of transfinite numbers. This is.
Kariminejad, Roxana; Lind-Thomsen, Allan; Tümer, Zeynep
2011-01-01
) to investigate copy number variants (CNVs) in a cohort of 169 patients with various structural brain malformations including lissencephaly, polymicrogyria, focal cortical dysplasia, and corpus callosum agenesis. The majority of the patients had intellectual disabilities (ID) and suffered from symptomatic...... that genes involved in "axonal transport," "cation transmembrane transporter activity," and the "c-Jun N-terminal kinase (JNK) cascade" play a significant role in the etiology of brain malformations. This is to the best of our knowledge the first systematic study of CNVs in patients with structural brain...
Ruppert, J.; Rahmede, C.; Bleicher, M.
2005-01-01
Within the ADD-model, we elaborate an idea by Vacavant and Hinchliffe [J. Phys. G 27 (2001) 1839] and show quantitatively how to determine the fundamental scale of TeV-gravity and the number of compactified extra dimensions from data at LHC. We demonstrate that the ADD-model leads to strong correlations between the missing E T in gravitons at different center of mass energies. This correlation puts strong constraints on this model for extra dimensions, if probed at s=5.5 TeV and s=14 TeV at LHC
Stumberger, Bojan; Stumberger, Gorazd; Hadziselimovic, Miralem; Hamler, Anton; Trlep, Mladen; Gorican, Viktor; Jesenik, Marko
2006-01-01
The paper presents a comparison between the performances of exterior-rotor permanent magnet brushless motors with distributed windings and the performances of exterior-rotor permanent magnet brushless motors with concentrated windings. Finite element method analysis is employed to determine the performance of each motor. It is shown that motors with concentrated windings and similar slot and pole numbers exhibit similar or better performances than motors with distributed windings for brushless AC (BLAC) operation mode and brushless DC (BLDC) operation mode as well
Radoi Emanuel
2004-01-01
Full Text Available In order to operate properly, the superresolution methods based on orthogonal subspace decomposition, such as multiple signal classification (MUSIC or estimation of signal parameters by rotational invariance techniques (ESPRIT, need accurate estimation of the signal subspace dimension, that is, of the number of harmonic components that are superimposed and corrupted by noise. This estimation is particularly difficult when the S/N ratio is low and the statistical properties of the noise are unknown. Moreover, in some applications such as radar imagery, it is very important to avoid underestimation of the number of harmonic components which are associated to the target scattering centers. In this paper, we propose an effective method for the estimation of the signal subspace dimension which is able to operate against colored noise with performances superior to those exhibited by the classical information theoretic criteria of Akaike and Rissanen. The capabilities of the new method are demonstrated through computer simulations and it is proved that compared to three other methods it carries out the best trade-off from four points of view, S/N ratio in white noise, frequency band of colored noise, dynamic range of the harmonic component amplitudes, and computing time.
Ji, Caleb; Khovanova, Tanya; Park, Robin; Song, Angela
2015-01-01
In this paper, we consider a game played on a rectangular $m \\times n$ gridded chocolate bar. Each move, a player breaks the bar along a grid line. Each move after that consists of taking any piece of chocolate and breaking it again along existing grid lines, until just $mn$ individual squares remain. This paper enumerates the number of ways to break an $m \\times n$ bar, which we call chocolate numbers, and introduces four new sequences related to these numbers. Using various techniques, we p...
Andrews, George E
1994-01-01
Although mathematics majors are usually conversant with number theory by the time they have completed a course in abstract algebra, other undergraduates, especially those in education and the liberal arts, often need a more basic introduction to the topic.In this book the author solves the problem of maintaining the interest of students at both levels by offering a combinatorial approach to elementary number theory. In studying number theory from such a perspective, mathematics majors are spared repetition and provided with new insights, while other students benefit from the consequent simpl
Yura, Yoshihiro; Takayasu, Hideki; Sornette, Didier; Takayasu, Misako
2015-10-01
We generalize the description of the dynamics of the order book of financial markets in terms of a Brownian particle embedded in a fluid of incoming, exiting, and annihilating particles by presenting a model of the velocity on each side (buy and sell) independently. The improved model builds on the time-averaged number of particles in the inner layer and its change per unit time, where the inner layer is revealed by the correlations between price velocity and change in the number of particles (limit orders). This allows us to introduce the Knudsen number of the financial Brownian particle motion and its asymmetric version (on the buy and sell sides). Not being considered previously, the asymmetric Knudsen numbers are crucial in finance in order to detect asymmetric price changes. The Knudsen numbers allows us to characterize the conditions for the market dynamics to be correctly described by a continuous stochastic process. Not questioned until now for large liquid markets such as the USD-JPY and EUR-USD exchange rates, we show that there are regimes when the Knudsen numbers are so high that discrete particle effects dominate, such as during market stresses and crashes. We document the presence of imbalances of particles depletion rates on the buy and sell sides that are associated with high Knudsen numbers and violent directional price changes. This indicator can detect the direction of the price motion at the early stage while the usual volatility risk measure is blind to the price direction.
Yura, Yoshihiro; Takayasu, Hideki; Sornette, Didier; Takayasu, Misako
2015-10-01
We generalize the description of the dynamics of the order book of financial markets in terms of a Brownian particle embedded in a fluid of incoming, exiting, and annihilating particles by presenting a model of the velocity on each side (buy and sell) independently. The improved model builds on the time-averaged number of particles in the inner layer and its change per unit time, where the inner layer is revealed by the correlations between price velocity and change in the number of particles (limit orders). This allows us to introduce the Knudsen number of the financial Brownian particle motion and its asymmetric version (on the buy and sell sides). Not being considered previously, the asymmetric Knudsen numbers are crucial in finance in order to detect asymmetric price changes. The Knudsen numbers allows us to characterize the conditions for the market dynamics to be correctly described by a continuous stochastic process. Not questioned until now for large liquid markets such as the USD-JPY and EUR-USD exchange rates, we show that there are regimes when the Knudsen numbers are so high that discrete particle effects dominate, such as during market stresses and crashes. We document the presence of imbalances of particles depletion rates on the buy and sell sides that are associated with high Knudsen numbers and violent directional price changes. This indicator can detect the direction of the price motion at the early stage while the usual volatility risk measure is blind to the price direction.
Barnes, John
2016-01-01
In this intriguing book, John Barnes takes us on a journey through aspects of numbers much as he took us on a geometrical journey in Gems of Geometry. Similarly originating from a series of lectures for adult students at Reading and Oxford University, this book touches a variety of amusing and fascinating topics regarding numbers and their uses both ancient and modern. The author intrigues and challenges his audience with both fundamental number topics such as prime numbers and cryptography, and themes of daily needs and pleasures such as counting one's assets, keeping track of time, and enjoying music. Puzzles and exercises at the end of each lecture offer additional inspiration, and numerous illustrations accompany the reader. Furthermore, a number of appendices provides in-depth insights into diverse topics such as Pascal’s triangle, the Rubik cube, Mersenne’s curious keyboards, and many others. A theme running through is the thought of what is our favourite number. Written in an engaging and witty sty...
Xu, G. S.; Wan, B. N.; Wang, H. Q.
2016-01-01
A new model for the low-to-high (L-H) confinement transition has been developed based on a new paradigm for turbulence suppression by velocity shear [G. M. Staebler et al., Phys. Rev. Lett.110, 055003 (2013)]. The model indicates that the L-H transition can be mediated by a shift in the radial wa...
Thorsen, Line; Azokpota, Paulin; Hansen, Bjarne Munk
The microbiology of the naturally fermented African condiments Afiitin, iru and sonru produced in Benin from locust beans, has recently been studied showing high Bacillus cereus counts of log7CFU/g (Azokpota, 2005). A total of 19 B. cereus strains isolated from the three condiments showed...
Policy makers need to understand how land cover change alters storm water regimes, yet existing methods do not fully utilize newly available datasets to quantify storm water changes at a landscape-scale. Here, we use high-resolution, remotely-sensed land cover, imperviousness, an...
Fairthorne, Jenny; Hanley, Gillian E; Oberlander, Tim F
2018-06-01
There is a higher prevalence of depression in women of low socioeconomic status (SES) than other women. Further, previous depression is the best predictor of future depression. Therefore, due to the negative effects of maternal depression on the fetus and subsequent child, particularly in combination with low SES, depression is ideally treated before pregnancy. During the year before pregnancy and by SES, we aimed to assess the odds of a physician visit associated with maternal depression and the mean number of physician visits in women by depressive status. We used population-based registry data of 243,933 women with 348,273 singleton live births in British Columbia from 1999 - 2009 and estimated family SES decile using tax-file data. Mixed effects logistic regression, adjusting for maternal age and parity, was used to calculate odds ratios and a two-sided, two-sample test was used to compare proportions. STATA 14 was used for analyses. Compared to women of middle SES (Decile-6), women of low SES (from Decile-1, Decile-2) had higher odds of more than 20 physician visits whether depressed (aOR = 1.46 (95% CI: (1.15, 1.86); aOR = 1.26 (95% CI: (0.98, 1.61)) or non-depressed (aOR = 1.26 (95% CI: (1.13, 1.41); aOR = 1.24 (95% CI: (1.11, 1.38)) during the year before pregnancy. During pre-pregnancy, depressed women had more than three times the mean number of physician visits than non-depressed women: (8.56 (8.38, 8.73) versus (2.59 (2.57, 2.61), P women of child-bearing age for depression and to refer for appropriate treatment. It is particularly important that physicians pay extra attention to identify depression in those of lower SES who are likely to become pregnant. Further, identifying depression and providing appropriate referral for treatment in all women who are likely to become pregnant, are already pregnant or are caring for children is important. In such a way, the possible negative effects of prenatal and post-partum depression, along with the interactive
Whitmore, Stephen A.; Petersen, Brian J.; Scott, David D.
1996-01-01
This paper develops a dynamic model for pressure sensors in continuum and rarefied flows with longitudinal temperature gradients. The model was developed from the unsteady Navier-Stokes momentum, energy, and continuity equations and was linearized using small perturbations. The energy equation was decoupled from momentum and continuity assuming a polytropic flow process. Rarefied flow conditions were accounted for using a slip flow boundary condition at the tubing wall. The equations were radially averaged and solved assuming gas properties remain constant along a small tubing element. This fundamental solution was used as a building block for arbitrary geometries where fluid properties may also vary longitudinally in the tube. The problem was solved recursively starting at the transducer and working upstream in the tube. Dynamic frequency response tests were performed for continuum flow conditions in the presence of temperature gradients. These tests validated the recursive formulation of the model. Model steady-state behavior was analyzed using the final value theorem. Tests were performed for rarefied flow conditions and compared to the model steady-state response to evaluate the regime of applicability. Model comparisons were excellent for Knudsen numbers up to 0.6. Beyond this point, molecular affects caused model analyses to become inaccurate.
Whitney, K G; Dasgupta, A; Davis, J; Coverdale, C A
2007-01-01
Two atomic models of the population dynamics of substates within the n 4 and n = 3 multiplets of nickel-like tungsten and beryllium-like iron, respectively, are described in this paper. The flexible atomic code (FAC) is used to calculate the collisional and radiative couplings and energy levels of the excited states within these ionization stages. These atomic models are then placed within larger principal-quantum-number-based ionization dynamic models of both tungsten and iron plasmas. Collisional-radiative equilibrium calculations are then carried out using these models that demonstrate how the multiplet substates depart from local thermodynamic equilibrium (LTE) as a function of ion density. The effect of these deviations from LTE on the radiative and collisional deexcitation rates of lumped 3s, 3p, 3d, 4s, 4p, 4d and 4f states is then calculated and least-squares fits to the density dependence of these lumped-state rate coefficients are obtained. The calculations show that, with the use of lumped-state models (which are in common use), one can accurately model the L- and M-shell ionization dynamics occurring in present-day Z-pinch experiments only through the addition of these extra, non-LTE-induced, rate coefficient density dependences. However, the derivation and use of low-order polynomial fits to these density dependences makes lumped-state modelling both viable and of value for post-processing analyses
High speed true random number generator with a new structure of coarse-tuning PDL in FPGA
Fang, Hongzhen; Wang, Pengjun; Cheng, Xu; Zhou, Keji
2018-03-01
A metastability-based TRNG (true random number generator) is presented in this paper, and implemented in FPGA. The metastable state of a D flip-flop is tunable through a two-stage PDL (programmable delay line). With the proposed coarse-tuning PDL structure, the TRNG core does not require extra placement and routing to ensure its entropy. Furthermore, the core needs fewer stages of coarse-tuning PDL at higher operating frequency, and thus saves more resources in FPGA. The designed TRNG achieves 25 Mbps @ 100 MHz throughput after proper post-processing, which is several times higher than other previous TRNGs based on FPGA. Moreover, the robustness of the system is enhanced with the adoption of a feedback system. The quality of the designed TRNG is verified by NIST (National Institute of Standards and Technology) and also accepted by class P1 of the AIS-20/31 test suite. Project supported by the S&T Plan of Zhejiang Provincial Science and Technology Department (No. 2016C31078), the National Natural Science Foundation of China (Nos. 61574041, 61474068, 61234002), and the K.C. Wong Magna Fund in Ningbo University, China.
Ooi, Seng-Keat
2005-11-01
Lock-exchange gravity current flows produced by the instantaneous release of a heavy fluid are investigated using 3-D well resolved Large Eddy Simulation simulations at Grashof numbers up to 8*10^9. It is found the 3-D simulations correctly predict a constant front velocity over the initial slumping phase and a front speed decrease proportional to t-1/3 (the time t is measured from the release) over the inviscid phase, in agreement with theory. The evolution of the current in the simulations is found to be similar to that observed experimentally by Hacker et al. (1996). The effect of the dynamic LES model on the solutions is discussed. The energy budget of the current is discussed and the contribution of the turbulent dissipation to the total dissipation is analyzed. The limitations of less expensive 2D simulations are discussed; in particular their failure to correctly predict the spatio-temporal distributions of the bed shear stresses which is important in determining the amount of sediment the gravity current can entrain in the case in advances of a loose bed.
Utsunomiya, S; Kushima, N; Katsura, K; Tanabe, S; Hayakawa, T; Sakai, H; Yamada, T; Takahashi, H; Abe, E; Wada, S; Aoyama, H [Niigata University, Niigata (Japan)
2016-06-15
Purpose: To establish a simple relation of backscatter dose enhancement around a high-Z dental alloy in head and neck radiation therapy to its average atomic number based on Monte Carlo calculations. Methods: The PHITS Monte Carlo code was used to calculate dose enhancement, which is quantified by the backscatter dose factor (BSDF). The accuracy of the beam modeling with PHITS was verified by comparing with basic measured data namely PDDs and dose profiles. In the simulation, a high-Z alloy of 1 cm cube was embedded into a tough water phantom irradiated by a 6-MV (nominal) X-ray beam of 10 cm × 10 cm field size of Novalis TX (Brainlab). The ten different materials of high-Z alloys (Al, Ti, Cu, Ag, Au-Pd-Ag, I, Ba, W, Au, Pb) were considered. The accuracy of calculated BSDF was verified by comparing with measured data by Gafchromic EBT3 films placed at from 0 to 10 mm away from a high-Z alloy (Au-Pd-Ag). We derived an approximate equation to determine the relation of BSDF and range of backscatter to average atomic number of high-Z alloy. Results: The calculated BSDF showed excellent agreement with measured one by Gafchromic EBT3 films at from 0 to 10 mm away from the high-Z alloy. We found the simple linear relation of BSDF and range of backscatter to average atomic number of dental alloys. The latter relation was proven by the fact that energy spectrum of backscatter electrons strongly depend on average atomic number. Conclusion: We found a simple relation of backscatter dose enhancement around high-Z alloys to its average atomic number based on Monte Carlo calculations. This work provides a simple and useful method to estimate backscatter dose enhancement from dental alloys and corresponding optimal thickness of dental spacer to prevent mucositis effectively.
Number names and number understanding
Ejersbo, Lisser Rye; Misfeldt, Morten
2014-01-01
This paper concerns the results from the first year of a three-year research project involving the relationship between Danish number names and their corresponding digits in the canonical base 10 system. The project aims to develop a system to help the students’ understanding of the base 10 syste...... the Danish number names are more complicated than in other languages. Keywords: A research project in grade 0 and 1th in a Danish school, Base-10 system, two-digit number names, semiotic, cognitive perspectives....
Theodore M. Porter
2012-12-01
Full Text Available The struggle over cure rate measures in nineteenth-century asylums provides an exemplary instance of how, when used for official assessments of institutions, these numbers become sites of contestation. The evasion of goals and corruption of measures tends to make these numbers “funny” in the sense of becoming dis-honest, while the mismatch between boring, technical appearances and cunning backstage manipulations supplies dark humor. The dangers are evident in recent efforts to decentralize the functions of governments and corporations using incen-tives based on quantified targets.
Murty, M Ram
2014-01-01
This book provides an introduction to the topic of transcendental numbers for upper-level undergraduate and graduate students. The text is constructed to support a full course on the subject, including descriptions of both relevant theorems and their applications. While the first part of the book focuses on introducing key concepts, the second part presents more complex material, including applications of Baker’s theorem, Schanuel’s conjecture, and Schneider’s theorem. These later chapters may be of interest to researchers interested in examining the relationship between transcendence and L-functions. Readers of this text should possess basic knowledge of complex analysis and elementary algebraic number theory.
Tzanos, C.P.
1992-01-01
A higher-order differencing method was recently proposed for the convection-diffusion equation, which even with a coarse mesh gives oscillation-free solutions that are far more accurate than those of the upwind scheme. In this paper, the performance of this method is investigated in conjunction with the performance of different iterative solvers for the solution of the Navier-Stokes equations in the vorticity-streamfunction formulation for incompressible flow at high Reynolds numbers. Flow in a square cavity with a moving lid was chosen as a model problem. Solvers that performed well at low Re numbers either failed to converge or had a computationally prohibitive convergence rate at high Re numbers. The additive correction method of Settari and Aziz and an iterative incomplete lower and upper (ILU) solver were used in a multigrid approach that performed well in the whole range of Re numbers considered (from 1000 to 10,000) and for uniform as well as nonuniform grids. At high Re numbers, point or line Gauss-Seidel solvers converged with uniform grids, but failed to converge with nonuniform grids
Tonn, Bruce Edward [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Rose, Erin M. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Hawkins, Beth A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
2014-09-01
The report presents fifteen individual case studies of high-performing and unique local weatherization agencies. This research was one component of the retrospective evaluation of the U.S. Department of Energy s Weatherization Assistance Program. The agencies were chosen to represent a range of contexts and approaches to weatherization. For example, the set of agencies includes a mix of urban and rural agencies, those that mainly use in-house crews to weatherize homes versus those that use contractor crews, and a mix of locations, from very cold climates to moderate to hot humid and dry climates. The case studies were mainly based on site visits to the agencies that encompassed interviews with program directors, weatherization crews, and recipients of weatherization. This information was supplemented by secondary materials. The cases document the diversity of contexts and challenges faced by the agencies and how they operate on a day-by-day basis. The cases also high common themes found throughout the agencies, such as their focus on mission and respect for their clients.
Ma, Zhiwen [National Renewable Energy Laboratory (NREL), Golden, CO (United States)
2017-09-05
As part of a Federal Opportunity Announcement (FOA) Award, the project will be led by Colorado School of Mines (CSM) to explore and demonstrate the efficacy of highly reducible, redox-stable oxides to provide efficient thermochemical energy storage for heat release at temperatures of 900 degrees Celcius or more. NREL will support the material development for its application in a concentrating solar power (CSP) plant. In the project, NREL will provide its inventive system design, chemical looping for CSP, and use it as a platform to accommodate the chemical processes using a cost effective perovskite materials identified by CSM. NREL will design a 5-10kW particle receiver for perovskite reduction to store solar energy and help the development of a fluidized-bed reoxidation reactor and system integration. NREL will develop the demonstration receiver for on-sun test in the 5-10 kWt range in NREL's high flux solar furnace. NREL will assist in system analysis and provide techno-economic inputs for the overall system configuration.
Hardwicke Mary
2011-07-01
Full Text Available Abstract Background Aurora kinases play critical roles in mitosis and are being evaluated as therapeutic targets in cancer. GSK1070916 is a potent, selective, ATP competitive inhibitor of Aurora kinase B and C. Translation of predictive biomarkers to the clinic can benefit patients by identifying the tumors that are more likely to respond to therapies, especially novel inhibitors such as GSK1070916. Methods 59 Hematological cancer-derived cell lines were used as models for response where in vitro sensitivity to GSK1070916 was based on both time and degree of cell death. The response data was analyzed along with karyotype, transcriptomics and somatic mutation profiles to determine predictors of response. Results 20 cell lines were sensitive and 39 were resistant to treatment with GSK1070916. High chromosome number was more prevalent in resistant cell lines (p-value = 0.0098, Fisher Exact Test. Greater resistance was also found in cell lines harboring polyploid subpopulations (p-value = 0.00014, Unpaired t-test. A review of NOTCH1 mutations in T-ALL cell lines showed an association between NOTCH1 mutation status and chromosome number (p-value = 0.0066, Fisher Exact Test. Conclusions High chromosome number associated with resistance to the inhibition of Aurora B and C suggests cells with a mechanism to bypass the high ploidy checkpoint are resistant to GSK1070916. High chromosome number, a hallmark trait of many late stage hematological malignancies, varies in prevalence among hematological malignancy subtypes. The high frequency and relative ease of measurement make high chromosome number a viable negative predictive marker for GSK1070916.
this is a characteristic difference between finite and infinite sets and created an immensely useful branch of mathematics based on this idea which had a great impact on the whole of mathe- matics. For example, the question of what is a number (finite or infinite) is almost a philosophical one. However Cantor's work turned it ...
Arendrup, Maiken Cavling; Fuursted, Kurt; Gahrn-Hansen, Bente
2005-01-01
laboratory systems documented a continuous increase of candidemia cases since the early 1990s. For the 272 susceptibility-tested isolates, MICs of amphotericin B and caspofungin were within the limits expected for the species or genus. However, decreased azole susceptibility, defined as a fluconazole MIC...... of >8 microg/ml and/or itraconazole MIC of >0.125 microg/ml, was detected for 11 Candida isolates that were neither C. glabrata nor C. krusei. Including intrinsically resistant fungi, we detected decreased susceptibility to fluconazole and/or itraconazole in 87 (32%) current Danish bloodstream fungal...... isolates. We showed a continuous increase of fungemia in Denmark and an annual rate in 2003 to 2004 higher than in most other countries. The proportion of bloodstream fungal isolates with reduced susceptibility to fluconazole and/or itraconazole was also notably high....
del Amo, Julia; González, Cristina; Geskus, Ronald B.; Torres, Montse; del Romero, Jorge; Viciana, Pompeyo; Masiá, Mar; Blanco, Jose R.; Hernández-Novoa, Beatriz; Ortiz, Marta; Peña, Alejandro; García, Federico; Torres, Montserrat; Ocampo, Antonio; Da Silva, Alfredo Rodríguez; Miralles, Celia; Mauricio Iribarren, Gustavo; Madrid, Nadia; Dronda, Fernando; Benito, Amparo; Sanz, Itziar; Vera, Mar; Rodríguez, Carmen; Martín Alegre, Carmen; Carlos Carrió, Juan; Raposo, Montse; Trastoy, Mónica; Fontillón, Maria; Robledano, Catalina; Gutierrez, Félix; Padilla, Sergio; Andrada, Encarna; Cervero, Miguel; Ramón Blanco, José; Pérez, Laura; Portilla, Joaquín; Portilla, Irene; Angel Vonwichmann, Miguel; Antonio Iribarren, José; Camino, Xabier; Sendagorta, Elena; Herranz, Pedro; Rodríguez, Patricia; Luis Gómez, Juan; Rosado, Dacil; Alejos, Belén; Angeles Rodríguez, Maria
2013-01-01
We estimated the effect of sexual behavior, age, and immunodeficiency on the number of high-risk human papillomavirus (HR-HPV) types in the anal canal among human immunodeficiency virus-positive men who have sex with men (MSM). Anal samples were genotyped with the Linear Array HPV Genotyping Test,
Gunnarsson, R.; Staaf, J.; Jansson, M.
2008-01-01
Screening for gene copy-number alterations (CNAs) has improved by applying genome-wide microarrays, where SNP arrays also allow analysis of loss of heterozygozity (LOH). We here analyzed 10 chronic lymphocytic leukemia (CLL) samples using four different high-resolution platforms: BAC arrays (32K)...
Gregoire eBorst
2013-12-01
Full Text Available The present high-density ERP study on 13 adults aimed to determine whether number conservation relies on the ability to inhibit the overlearned length-equals-number strategy and then imagine the shortening of the row that was lengthened. Participants performed the number-conservation task and, after the EEG session, the mental imagery task. In the number-conservation task, first two rows with the same number of tokens and the same length were presented on a computer screen (COV condition and then, the tokens in one of the two rows were spread apart (INT condition. Participants were instructed to determine whether the two rows had an identical number of tokens. In the mental imagery task, two rows with different lengths but the same number of tokens were presented and participants were instructed to imagine the tokens in the longer row aligning with the tokens in the shorter row. In the number-conservation task, we found that the amplitudes of the centro-parietal N2 and fronto-central P3 were higher in the INT than in the COV conditions. In addition, the differences in response times between the two conditions were correlated with the differences in the amplitudes of the fronto-central P3. In light of previous results reported on the number-conservation task in adults, the present results suggest that inhibition might be necessary to succeed the number-conservation task in adults even when the transformation of the length of one of the row is displayed. Finally, we also reported correlations between the speed at which participants could imagine the shortening of one of the row in the mental imagery task, the speed at which participants could determine that the two rows had the same number of tokens after the tokens in one of the row were spread apart and the latency of the late positive parietal component in the number-conservation task. Therefore, performing the number-conservation task might involve mental transformation processes in adults.
Vanselow, Jens; Kucia, Marzena; Langhammer, Martina; Koczan, Dirk; Metges, Cornelia C
2016-04-01
Indirect effects of a high-protein maternal diet are not well understood. In this study, we analyzed short-term and sustainable effects of a prenatal versus early postnatal maternal high-protein diet on growth and hepatic gene expression in mouse offspring. Dams were exposed to an isoenergetic high-protein (HP, 40 % w/w) diet during pregnancy or lactation. Growth and hepatic expression profiles of male offspring were evaluated directly after weaning and 150 days after birth. Offspring from two dietary groups, high-protein diet during pregnancy and control diet during lactation (HPC), and control diet during pregnancy and high-protein diet during lactation (CHP), were compared with offspring (CC) from control-fed dams. Maternal CHP treatment was associated with sustained offspring growth retardation, but decreased numbers of affected hepatic genes in adults compared to weanlings. In contrast, offspring of the HPC group did not show persistent effects on growth parameters, but the number of affected hepatic genes was even increased at adult age. In both dietary groups, however, only a small subset of genes was affected in weanlings as well as in adults. We conclude that (1) prenatal and early postnatal maternal HP diet caused persistent, but (2) different effects and partially complementary trends on growth characteristics and on the hepatic transcriptome and associated pathways and that (3) only a small number of genes and associated upstream regulators might be involved in passing early diet-induced imprints to adulthood.
Draeger, Tracie; Moore, Graham
2017-09-01
Exposure of wheat to high temperatures during male meiosis prevents normal meiotic progression and reduces grain number. We define a temperature-sensitive period and link heat tolerance to chromosome 5D. This study assesses the effects of heat on meiotic progression and grain number in hexaploid wheat (Triticum aestivum L. var. Chinese Spring), defines a heat-sensitive stage and evaluates the role of chromosome 5D in heat tolerance. Plants were exposed to high temperatures (30 or 35 °C) in a controlled environment room for 20-h periods during meiosis and the premeiotic interphase just prior to meiosis. Examination of pollen mother cells (PMCs) from immature anthers immediately before and after heat treatment enabled precise identification of the developmental phases being exposed to heat. A temperature-sensitive period was defined, lasting from premeiotic interphase to late leptotene, during which heat can prevent PMCs from progressing through meiosis. PMCs exposed to 35 °C were less likely to progress than those exposed to 30 °C. Grain number per spike was reduced at 30 °C, and reduced even further at 35 °C. Chinese Spring nullisomic 5D-tetrasomic 5B (N5DT5B) plants, which lack chromosome 5D, were more susceptible to heat during premeiosis-leptotene than Chinese Spring plants with the normal (euploid) chromosome complement. The proportion of plants with PMCs progressing through meiosis after heat treatment was lower for N5DT5B plants than for euploids, but the difference was not significant. However, following exposure to 30 °C, in euploid plants grain number was reduced (though not significantly), whereas in N5DT5B plants the reduction was highly significant. After exposure to 35 °C, the reduction in grain number was highly significant for both genotypes. Implications of these findings for the breeding of thermotolerant wheat are discussed.
Komatsu, F; Ishida, Y
1997-04-01
For chronic myelocytic leukemia patients with very high numbers of platelets, we describe an efficient method for the collection of peripheral blood stem cells (PBSC) using the Fresenius AS104 cell separator. In these patients, it is difficult to collect a sufficient number of PBSC, due to the platelet band interfering with the machine's red cell interface sensor. We, therefore, tried a manual adjustment of the device. The collection phase was set automatically. When the whole blood began to separate into the red cell layer and plasma (plus mononuclear cell) layer, the red cell interface setting of "7:1" was changed to "OFF," and the plasma pump flow rate was controlled manually in order to locate the interface position 1 cm from the outside wall of the centrifuge chamber. After the collection phase, the procedure was returned to the automatic setting. By repeating this procedure, we were able to collect large numbers of PBSC.
Konrath, Robert; Geisler, Reinhard; Otter, Dirk; Philipp, Florian; Ehlers, Hauke; Agocs, Janos; Quest, Jürgen
2015-01-01
Within the framework of the EU project ESWIRP the Particle Image Velocimetry (PIV) using high-speed camera and laser has been used to measure the turbulent flow in the wake of a stalled aircraft wing. The measurements took place on the Common Research Model (CRM) provided by NASA in the pressurized cryogenic European Transonic Wind tunnel (ETW). A specific cryo-PIV system has been used and adapted for using high-speed PIV components under the cryogenic conditions of the wind tunnel faci...
Moualeu, Leolein Patrick Gouemeni
Runway-independent aircraft are expected to be the future for short-haul flights by improving air transportation and reducing area congestion encountered in airports. The Vehicle Systems Program of NASA identified a Large Civil Tilt-Rotor, equipped with variable-speed power-turbine engines, as the best concept. At cruise altitude, the engine rotor-speed will be reduced by as much as the 50% of take-off speed. The large incidence variation in the low pressure turbine associated with the change in speed can be detrimental to the engine performance. Low pressure turbine blades in cruise altitude are more predisposed to develop regions of boundary layer separation. Typical phenomenon such as impinging wakes on downstream blades and mainstream turbulences enhance the complexity of the flow in low pressure turbines. It is therefore important to be able to understand the flow behavior to accurately predict the losses. Research facilities are seldom able to experimentally reproduce low Reynolds numbers at relevant engine Mach number. Having large incidence swing as an additional parameter in the investigation of the boundary layer development, on a low pressure turbine blade, makes this topic unique and as a consequence requires a unique facility to conduct the experimental research. The compressible flow wind tunnel facility at the University of North Dakota had been updated to perform steady state experiments on a modular-cascade, designed to replicate a large variation of the incidence angles. The high speed and low Reynolds number facility maintained a sealed and closed loop configuration for each incidence angle. The updated facility is capable to produce experimental Reynolds numbers as low as 45,000 and as high as 570,000 at an exit Mach number of 0.72. Pressure and surface temperature measurements were performed at these low pressure turbine conditions. The present thesis investigates the boundary layer development on the surface of an Incidence-tolerant blade. The
Nikolay Petrovich Vasilyev
2015-03-01
Full Text Available The paper describes the scope of information security protocols based on PRN G in industrial systems. A method for implementing three-dimensional pseudorandom number generator D O Z E N in hybrid systems is provided. The description and results of studies parallel CUDA-version of the algorithm for use in hybrid data centers and high-performance FPGA-version for use in hardware solutions in controlled facilities of SCADA-systems are given.
Meng, Xuhui; Guo, Zhaoli
2015-10-01
A lattice Boltzmann model with a multiple-relaxation-time (MRT) collision operator is proposed for incompressible miscible flow with a large viscosity ratio as well as a high Péclet number in this paper. The equilibria in the present model are motivated by the lattice kinetic scheme previously developed by Inamuro et al. [Philos. Trans. R. Soc. London, Ser. A 360, 477 (2002), 10.1098/rsta.2001.0942]. The fluid viscosity and diffusion coefficient depend on both the corresponding relaxation times and additional adjustable parameters in this model. As a result, the corresponding relaxation times can be adjusted in proper ranges to enhance the performance of the model. Numerical validations of the Poiseuille flow and a diffusion-reaction problem demonstrate that the proposed model has second-order accuracy in space. Thereafter, the model is used to simulate flow through a porous medium, and the results show that the proposed model has the advantage to obtain a viscosity-independent permeability, which makes it a robust method for simulating flow in porous media. Finally, a set of simulations are conducted on the viscous miscible displacement between two parallel plates. The results reveal that the present model can be used to simulate, to a high level of accuracy, flows with large viscosity ratios and/or high Péclet numbers. Moreover, the present model is shown to provide superior stability in the limit of high kinematic viscosity. In summary, the numerical results indicate that the present lattice Boltzmann model is an ideal numerical tool for simulating flow with a large viscosity ratio and/or a high Péclet number.
Flegel, Ashlie B.; Giel, Paul W.; Welch, Gerard E.
2014-01-01
The effects of high inlet turbulence intensity on the aerodynamic performance of a variable speed power turbine blade are examined over large incidence and Reynolds number ranges. These results are compared to previous measurements made in a low turbulence environment. Both high and low turbulence studies were conducted in the NASA Glenn Research Center Transonic Turbine Blade Cascade Facility. The purpose of the low inlet turbulence study was to examine the transitional flow effects that are anticipated at cruise Reynolds numbers. The current study extends this to LPT-relevant turbulence levels while perhaps sacrificing transitional flow effects. Assessing the effects of turbulence at these large incidence and Reynolds number variations complements the existing database. Downstream total pressure and exit angle data were acquired for 10 incidence angles ranging from +15.8deg to -51.0deg. For each incidence angle, data were obtained at five flow conditions with the exit Reynolds number ranging from 2.12×10(exp 5) to 2.12×10(exp 6) and at a design exit Mach number of 0.72. In order to achieve the lowest Reynolds number, the exit Mach number was reduced to 0.35 due to facility constraints. The inlet turbulence intensity, Tu, was measured using a single-wire hotwire located 0.415 axial-chord upstream of the blade row. The inlet turbulence levels ranged from 8 to 15 percent for the current study. Tu measurements were also made farther upstream so that turbulence decay rates could be calculated as needed for computational inlet boundary conditions. Downstream flow field measurements were obtained using a pneumatic five-hole pitch/yaw probe located in a survey plane 7 percent axial chord aft of the blade trailing edge and covering three blade passages. Blade and endwall static pressures were acquired for each flow condition as well. The blade loading data show that the suction surface separation that was evident at many of the low Tu conditions has been eliminated. At
Mascarenhas Cláudia
2008-11-01
Full Text Available Abstract Background Hereditary Hemochromatosis(HH is a common genetic disorder of iron overload where the large majority of patients are homozygous for one ancestral mutation in the HFE gene. In spite of this remarkable genetic homogeneity, the condition is clinically heterogeneous, varying from a severe disease to an asymptomatic phenotype with only abnormal biochemical parameters. The recent recognition of the variable penetrance of the HH mutation in different large population studies demands the need to search for new modifiers of its phenotypic expression. The present study follows previous observations that MHC class-I linked genetic markers, associated with the setting of CD8+ T-lymphocyte numbers, could be clinically relevant modifiers of the phenotypic expression in HH, and aimed to find new markers that could be used as more reliable prognostic variables. Methods Haplotype analysis, including seven genetic markers within a 1 Mb region around the microsatellite D6S105 was performed in a group of 56 previously characterized C282Y homozygous Portuguese patients. Parameters analyzed in this study were total body iron stores, clinical manifestations related with HH and immunological parameters (total lymphocyte numbers, CD4+ and CD8+ T-lymphocyte numbers. An independent group of 10 C282Y homozygous patients from Vancouver, Canada, were also included in this study and analyzed for the same parameters. Results A highly conserved ancestral haplotype defined by the SNP markers PGBD1-A, ZNF193-A, ZNF165-T (designated as A-A-T was found associated with both abnormally low CD8+ T-lymphocyte numbers and the development of a severe clinical expression of HH. In a small proportion of patients, another conserved haplotype defined by the SNP markers PGBD1-G, ZNF193-G, ZNF165-G (designated as G-G-G was found associated with high CD8+ T-lymphocyte numbers and a milder clinical expression. Remarkably, the two conserved haplotypes defined in Portuguese
Barra, Nicole G; Fan, Isabella Y; Gillen, Jenna B; Chew, Marianne; Marcinko, Katarina; Steinberg, Gregory R; Gibala, Martin J; Ashkar, Ali A
2017-12-01
High intensity interval training (HIIT) boosts natural killer (NK) cell number and activity in normal weight breast cancer patients; however, whether this occurs in obese individuals is not well established. The goal of this study was to determine whether HIIT effectively boosts NK cells as a therapeutic strategy against breast cancer in an obese mouse model and in overweight/obese women. Diet induced female C57Bl/6 obese mice were assigned to undergo HIIT for four weeks or remain sedentary. Female participants were subjected to a six weeks HIIT protocol. HIIT mice acclimatized to treadmill running were subsequently injected with 5 × 10 5 polyoma middle T (MT) breast cancer cells intravenously. NK cell number and activation were monitored using flow cytometry, and tumor burden or lipid content evaluated from histological lung and liver tissues, respectively. In both mice and humans, circulating NK cell number and activation (CD3-NK1.1+CD27+ and CD3-CD56+, respectively) markedly increased immediately after HIIT. HIIT obese mice had reduced lung tumor burden compared to controls following MT challenge, and had diminished hepatic lipid deposition despite minimal body weight loss. Our findings demonstrate that HIIT can benefit obese individuals by enhancing NK cell number and activity, reducing tumor burden, and enhancing metabolic health.
Peter Bachant
2016-01-01
Full Text Available Experiments were performed with a large laboratory-scale high solidity cross-flow turbine to investigate Reynolds number effects on performance and wake characteristics and to establish scale thresholds for physical and numerical modeling of individual devices and arrays. It was demonstrated that the performance of the cross-flow turbine becomes essentially R e -independent at a Reynolds number based on the rotor diameter R e D ≈ 10 6 or an approximate average Reynolds number based on the blade chord length R e c ≈ 2 × 10 5 . A simple model that calculates the peak torque coefficient from static foil data and cross-flow turbine kinematics was shown to be a reasonable predictor for Reynolds number dependence of an actual cross-flow turbine operating under dynamic conditions. Mean velocity and turbulence measurements in the near-wake showed subtle differences over the range of R e investigated. However, when transport terms for the streamwise momentum and mean kinetic energy were calculated, a similar R e threshold was revealed. These results imply that physical model studies of cross-flow turbines should achieve R e D ∼ 10 6 to properly approximate both the performance and wake dynamics of full-scale devices and arrays.
Q. T. Nguyen
2016-09-01
Full Text Available This work presents an analysis of the physical properties of sub-micrometer aerosol particles measured at the high Arctic site Villum Research Station, Station Nord (VRS, northeast Greenland, between July 2010 and February 2013. The study focuses on particle number concentrations, particle number size distributions and the occurrence of new particle formation (NPF events and their seasonality in the high Arctic, where observations and characterization of such aerosol particle properties and corresponding events are rare and understanding of related processes is lacking.A clear accumulation mode was observed during the darker months from October until mid-May, which became considerably more pronounced during the prominent Arctic haze months from March to mid-May. In contrast, nucleation- and Aitken-mode particles were predominantly observed during the summer months. Analysis of wind direction and wind speed indicated possible contributions of marine sources from the easterly side of the station to the observed summertime particle number concentrations, while southwesterly to westerly winds dominated during the darker months. NPF events lasting from hours to days were mostly observed from June until August, with fewer events observed during the months with less sunlight, i.e., March, April, September and October. The results tend to indicate that ozone (O3 might be weakly anti-correlated with particle number concentrations of the nucleation-mode range (10–30 nm in almost half of the NPF events, while no positive correlation was observed. Calculations of air mass back trajectories using the Hybrid Single Particle Lagrangian Integrated Trajectory (HYSPLIT model for the NPF event days suggested that the onset or interruption of events could possibly be explained by changes in air mass origin. A map of event occurrence probability was computed, indicating that southerly air masses from over the Greenland Sea were more likely linked to those
Elbing, Brian R.; Perlin, Marc; Dowling, David R.; Ceccio, Steven L.
2013-08-01
The current study explores the influence of polymer drag reduction on the near-wall velocity distribution in a turbulent boundary layer (TBL) and its dependence on Reynolds number. Recent moderate Reynolds number direct numerical simulation and experimental studies presented in White et al. [Phys. Fluids 24, 021701 (2012)], 10.1063/1.3681862 have challenged the classical representation of the logarithmic dependence of the velocity profile for drag-reduced flows, especially at drag reduction levels above 40%. In the present study, high Reynolds number data from a drag reduced TBL is presented and compared to the observations of White et al. [Phys. Fluids 24, 021701 (2012)], 10.1063/1.3681862. Data presented here were acquired in the TBL flow on a 12.9-m-long flat plate at speeds to 20.3 m s-1, achieving momentum thickness based Reynolds number to 1.5 × 105, which is an order of magnitude greater than that available in the literature. Polyethylene oxide solutions with an average molecular weight of 3.9 × 106 g mol-1 were injected into the flow at various concentrations and volumetric fluxes to achieve a particular level of drag reduction. The resulting mean near-wall velocity profiles show distinctly different behavior depending on whether they fall in the low drag reduction (LDR) or the high drag reduction (HDR) regimes, which are nominally divided at 40% drag reduction. In the LDR regime, the classical view that the logarithmic slope remains constant at the Newtonian value and the intercept constant increases with increasing drag reduction appears to be valid. However, in the HDR regime the behavior is no longer universal. The intercept constant continues to increase linearly in proportion to the drag reduction level until a Reynolds-number-dependent threshold is achieved, at which point the intercept constant rapidly decreases to that predicted by the ultimate profile. The rapid decrease in the intercept constant is due to the corresponding increase in the
Martin Winter
2013-08-01
Full Text Available We report on studies of an inorganic electrolyte: LiAlCl4 in liquid sulfur dioxide. Concentrated solutions show a very high conductivity when compared with typical electrolytes for lithium ion batteries that are based on organic solvents. Our investigations include conductivity measurements and measurements of transference numbers via nuclear magnetic resonance (NMR and by a classical direct method, Hittorf’s method. For the use of Hittorf’s method, it is necessary to measure the concentration of the electrolyte in a selected cell compartment before and after electrochemical polarization very precisely. This task was finally performed by potentiometric titration after hydrolysis of the salt. The Haven ratio was determined to estimate the association behavior of this very concentrated electrolyte solution. The measured unusually high transference number of the lithium cation of the studied most concentrated solution, a molten solvate LiAlCl4 × 1.6SO2, makes this electrolyte a promising alternative for lithium ion cells with high power ability.
Moriya, Tomoyuki; Fukatsu, Kazuhiko; Noguchi, Midori; Okamoto, Koichi; Murakoshi, Satoshi; Saitoh, Daizoh; Miyazaki, Masaru; Hase, Kazuo; Yamamoto, Junji
2014-02-01
Chemotherapy remains a mainstay of treatment for cancer patients. However, anti-cancer drugs frequently cause a wide range of side effects, including leukopenia and gastrointestinal toxicity. These adverse effects can lead to treatment delays or necessitate temporary dose reductions. Although chemotherapy-related changes in gut morphology have been demonstrated, the influences of chemotherapeutic regimens on gut immunity are understood poorly. This study aimed to examine whether the anti-cancer drug paclitaxel (PTX) impairs gut immunity in mice. Male ICR mice were randomized into three groups: Control, low-dose PTX (low PTX; 2 mg/kg), or high-dose PTX (high PTX; 4 mg/kg). A single intravenous dose was given. On day seven after the injection, lymphocytes from Peyer patches (PP), intraepithelial (IE) spaces, and the lamina propria (LP) were counted and analyzed by flow cytometry (CD4(+), CD8(+), αβTCR(+), γδTCR(+), B220(+)). Immunoglobulin A (IgA) concentrations were measured in small intestinal and respiratory tract washings. Total, CD4(+) and γδTCR(+) lymphocyte numbers in PPs were significantly lower in the high PTX than in the control group. The CD4(+) lymphocyte numbers in the IE spaces were significantly lower in both PTX groups than in the control group. Respiratory tract IgA concentrations were lower in the high PTX than in the control group. The present data suggest high-dose PTX impairs mucosal immunity, possibly rendering patients more vulnerable to infection. Careful dose selection and new therapies may be important for maintaining mucosal immunity during PTX chemotherapy.
Operating a Demographic Surveillance System (DSS) like this one requires a blend of high-tech number-crunching ability and .... views follow a standardized format that takes several ... general levels of health and to the use of health services.
Bell, Griffith; Mora, Samia; Greenland, Philip; Tsai, Michael; Gill, Ed; Kaufman, Joel D
2017-05-01
The relationship between air pollution and cardiovascular disease may be explained by changes in high-density lipoprotein (HDL). We examined the cross-sectional relationship between air pollution and both HDL cholesterol and HDL particle number in the MESA Air study (Multi-Ethnic Study of Atherosclerosis Air Pollution). Study participants were 6654 white, black, Hispanic, and Chinese men and women aged 45 to 84 years. We estimated individual residential ambient fine particulate pollution exposure (PM 2.5 ) and black carbon concentrations using a fine-scale likelihood-based spatiotemporal model and cohort-specific monitoring. Exposure periods were averaged to 12 months, 3 months, and 2 weeks prior to examination. HDL cholesterol and HDL particle number were measured in the year 2000 using the cholesterol oxidase method and nuclear magnetic resonance spectroscopy, respectively. We used multivariable linear regression to examine the relationship between air pollution exposure and HDL measures. A 0.7×10 - 6 m - 1 higher exposure to black carbon (a marker of traffic-related pollution) averaged over a 1-year period was significantly associated with a lower HDL cholesterol (-1.68 mg/dL; 95% confidence interval, -2.86 to -0.50) and approached significance with HDL particle number (-0.55 mg/dL; 95% confidence interval, -1.13 to 0.03). In the 3-month averaging time period, a 5 μg/m 3 higher PM 2.5 was associated with lower HDL particle number (-0.64 μmol/L; 95% confidence interval, -1.01 to -0.26), but not HDL cholesterol (-0.05 mg/dL; 95% confidence interval, -0.82 to 0.71). These data are consistent with the hypothesis that exposure to air pollution is adversely associated with measures of HDL. © 2017 American Heart Association, Inc.
Xu, Xia; Deng, Fei; Lv, Mengmeng; Chen, Xiaoxiang
2017-02-01
No consensus exists on the number of chemotherapy cycles to be administered before and after interval debulking surgery (IDS) in patients with advanced stage epithelial ovarian cancer. The present study aims to explore the optimal number of cycles of neoadjuvant chemotherapy (NAC) and post-operation chemotherapy to treat the International Federation of Gynecology and Obstetrics stage IIIc-IV high-grade serous ovarian cancer (HG-SOC). A total of 129 IIIc-IV stage HG-SOC cases were retrospectively analyzed. Cases were comprised of patients who underwent NAC followed by IDS and who achieved clinical complete response (CCR) at the end of primary therapy. Patients were recruited from the Jiangsu Institute of Cancer Research between 1993 and 2013. Optimal IDS-associated factors were explored with logistic regression. The association between progression-free survival (PFS), overall survival (OS) duration, and covariates was assessed by Cox proportional hazards model and log-rank test. The median number of NAC cycle was 3 (range 1-8). CA-125 decreasing kinetics (p = 0.01) was independently associated with optimal IDS. CA-125 decreasing kinetics, optimal IDS, and NAC cycles was independently associated with OS (p cycles was shorter than those of patients who underwent cycles (12.3 versus 17.2 months). The PFS and OS of patients who underwent cycles of adjuvant chemotherapy post-IDS were shorter than those of patients who underwent ≥5 cycles (14.2 and 20.3 versus 21.2 and 28.8 months). NAC cycles, CA-125 decreasing kinetics, and optimal debulking are independently associated with the prognosis of patients with advanced stage HG-SOC who underwent NAC/IDS and achieved CCR. The number of administered NAC cycles should not exceed 4.
Varala Kranthi
2007-05-01
Full Text Available Abstract Background Extensive computational and database tools are available to mine genomic and genetic databases for model organisms, but little genomic data is available for many species of ecological or agricultural significance, especially those with large genomes. Genome surveys using conventional sequencing techniques are powerful, particularly for detecting sequences present in many copies per genome. However these methods are time-consuming and have potential drawbacks. High throughput 454 sequencing provides an alternative method by which much information can be gained quickly and cheaply from high-coverage surveys of genomic DNA. Results We sequenced 78 million base-pairs of randomly sheared soybean DNA which passed our quality criteria. Computational analysis of the survey sequences provided global information on the abundant repetitive sequences in soybean. The sequence was used to determine the copy number across regions of large genomic clones or contigs and discover higher-order structures within satellite repeats. We have created an annotated, online database of sequences present in multiple copies in the soybean genome. The low bias of pyrosequencing against repeat sequences is demonstrated by the overall composition of the survey data, which matches well with past estimates of repetitive DNA content obtained by DNA re-association kinetics (Cot analysis. Conclusion This approach provides a potential aid to conventional or shotgun genome assembly, by allowing rapid assessment of copy number in any clone or clone-end sequence. In addition, we show that partial sequencing can provide access to partial protein-coding sequences.
Salawu, Abdulazeez; Ul-Hassan, Aliya; Hammond, David; Fernando, Malee; Reed, Malcolm; Sisley, Karen
2012-01-01
Most soft tissue sarcomas are characterized by genetic instability and frequent genomic copy number aberrations that are not subtype-specific. Oligonucleotide microarray-based Comparative Genomic Hybridisation (array CGH) is an important technique used to map genome-wide copy number aberrations, but the traditional requirement for high-quality DNA typically obtained from fresh tissue has limited its use in sarcomas. Although large archives of Formalin-fixed Paraffin-embedded (FFPE) tumour samples are available for research, the degradative effects of formalin on DNA from these tissues has made labelling and analysis by array CGH technically challenging. The Universal Linkage System (ULS) may be used for a one-step chemical labelling of such degraded DNA. We have optimised the ULS labelling protocol to perform aCGH on archived FFPE leiomyosarcoma tissues using the 180k Agilent platform. Preservation age of samples ranged from a few months to seventeen years and the DNA showed a wide range of degradation (when visualised on agarose gels). Consistently high DNA labelling efficiency and low microarray probe-to-probe variation (as measured by the derivative log ratio spread) was seen. Comparison of paired fresh and FFPE samples from identical tumours showed good correlation of CNAs detected. Furthermore, the ability to macro-dissect FFPE samples permitted the detection of CNAs that were masked in fresh tissue. Aberrations were visually confirmed using Fluorescence in situ Hybridisation. These results suggest that archival FFPE tissue, with its relative abundance and attendant clinical data may be used for effective mapping for genomic copy number aberrations in such rare tumours as leiomyosarcoma and potentially unravel clues to tumour origins, progression and ultimately, targeted treatment. PMID:23209738
Özcan Saygın
2017-12-01
Full Text Available Aim: The purpose of this study is to compare the body mass index and daily steps number of secondary and high school students in Mugla region according to age and gender. Material and Methods: A total of 1851 volunteer students (682 secondary school students and 1169 high school students participated in this study. Physical activity level was determined by measuring daily step numbers of students with a pedometer. Body mass index (kg/m2 was calculated by utilizing from height and weight measurements in order to find body composition. Acquired data was recorded in SPSS (18.0 program. In order to find a difference in body composition and physical activity level between gender, Independent t-test was applied. One-way Anova was applied in order to find the differences among ages. Tukey HSD Analysis was used to find from which age the difference stemmed from. Frequencies and percentages values were calculated to assess the number of daily steps and body mass index standards, and chi-square analysis was used to find differences according to sex. Results: As a result of the statistical analyse; statistically significant difference was found in the physical activity level of secondary school students, it was also found both high school student’s body composition and physical activity levels of high school students according to gender (p<0.05. While the body mass index values of both male and female students tend to increase with age, the physical activity level of both students tends to decrease with age. Statistically, a significant difference was found when the daily step count standards were compared by sex (X2=23.999 p=0.000. It was found that 65.91% (n=698 of the female students and 49.87% (n=395 of the male students were below the normal values of the daily step counts. Statistically, a significant difference was found when the body mass index standards were compared by sex (X2=15.702, p=0.000. It was seen that 16.90% of female students (n=179
Jürgen Grünberg
Full Text Available Site-specific enzymatic reactions with microbial transglutaminase (mTGase lead to a homogenous species of immunoconjugates with a defined ligand/antibody ratio. In the present study, we have investigated the influence of different numbers of 1,4,7,10-tetraazacyclododecane-N-N'-N''-N'''-tetraacetic acid (DOTA chelats coupled to a decalysine backbone on the in vivo behavior of the chimeric monoclonal anti-L1CAM antibody chCE7agl. The enzymatic conjugation of (DOTA1-decalysine, (DOTA3-decalysine or (DOTA5-decalysine to the antibody heavy chain (via Gln295/297 gave rise to immunoconjugates containing two, six or ten DOTA moieties respectively. Radiolabeling of the immunoconjugates with (177Lu yielded specific activities of approximately 70 MBq/mg, 400 MBq/mg and 700 MBq/mg with increasing numbers of DOTA chelates. Biodistribution experiments in SKOV3ip human ovarian cancer cell xenografts demonstrated a high and specific accumulation of radioactivity at the tumor site for all antibody derivatives with a maximal tumor accumulation of 43.6±4.3% ID/g at 24 h for chCE7agl-[(DOTA-decalysine]2, 30.6±12.0% ID/g at 24 h for chCE7agl-[(DOTA3-decalysine]2 and 49.9±3.1% ID/g at 48 h for chCE7agl-[(DOTA5-decalysine]2. The rapid elimination from the blood of chCE7agl-[(DOTA-decalysine]2 (1.0±0.1% ID/g at 24 h is associated with a high liver accumulation (23.2±4.6% ID/g at 24 h. This behavior changed depending on the numbers of DOTA moieties coupled to the decalysine peptide with a slower blood clearance (5.1±1.0 (DOTA3 versus 11.7±1.4% ID/g (DOTA5, p<0.005 at 24 h and lower radioactivity levels in the liver (21.4±3.4 (DOTA3 versus 5.8±0.7 (DOTA5, p<0.005 at 24 h. We conclude that the site-specific and stoichiometric uniform conjugation of the highly DOTA-substituted decalysine ((DOTA5-decalysine to an anti-tumor antibody leads to the formation of immunoconjugates with high specific activity and excellent in vivo behavior and is a valuable option for
Do, Hongdo; Dobrovic, Alexander
2009-10-08
Mutation detection in clinical tumour samples is challenging when the proportion of tumour cells, and thus mutant alleles, is low. The limited sensitivity of conventional sequencing necessitates the adoption of more sensitive approaches. High resolution melting (HRM) is more sensitive than sequencing but identification of the mutation is desirable, particularly when it is important to discriminate false positives due to PCR errors or template degradation from true mutations.We thus developed limited copy number - high resolution melting (LCN-HRM) which applies limiting dilution to HRM. Multiple replicate reactions with a limited number of target sequences per reaction allow low level mutations to be detected. The dilutions used (based on Ct values) are chosen such that mutations, if present, can be detected by the direct sequencing of amplicons with aberrant melting patterns. Using cell lines heterozygous for mutations, we found that the mutations were not readily detected when they comprised 10% of total alleles (20% tumour cells) by sequencing, whereas they were readily detectable at 5% total alleles by standard HRM. LCN-HRM allowed these mutations to be identified by direct sequencing of those positive reactions.LCN-HRM was then used to review formalin-fixed paraffin-embedded (FFPE) clinical samples showing discordant findings between sequencing and HRM for KRAS exon 2 and EGFR exons 19 and 21. Both true mutations present at low levels and sequence changes due to artefacts were detected by LCN-HRM. The use of high fidelity polymerases showed that the majority of the artefacts were derived from the damaged template rather than replication errors during amplification. LCN-HRM bridges the sensitivity gap between HRM and sequencing and is effective in distinguishing between artefacts and true mutations.
Grünberg, Jürgen; Jeger, Simone; Sarko, Dikran; Dennler, Patrick; Zimmermann, Kurt; Mier, Walter; Schibli, Roger
2013-01-01
Site-specific enzymatic reactions with microbial transglutaminase (mTGase) lead to a homogenous species of immunoconjugates with a defined ligand/antibody ratio. In the present study, we have investigated the influence of different numbers of 1,4,7,10-tetraazacyclododecane-N-N'-N''-N'''-tetraacetic acid (DOTA) chelats coupled to a decalysine backbone on the in vivo behavior of the chimeric monoclonal anti-L1CAM antibody chCE7agl. The enzymatic conjugation of (DOTA)1-decalysine, (DOTA)3-decalysine or (DOTA)5-decalysine to the antibody heavy chain (via Gln295/297) gave rise to immunoconjugates containing two, six or ten DOTA moieties respectively. Radiolabeling of the immunoconjugates with (177)Lu yielded specific activities of approximately 70 MBq/mg, 400 MBq/mg and 700 MBq/mg with increasing numbers of DOTA chelates. Biodistribution experiments in SKOV3ip human ovarian cancer cell xenografts demonstrated a high and specific accumulation of radioactivity at the tumor site for all antibody derivatives with a maximal tumor accumulation of 43.6±4.3% ID/g at 24 h for chCE7agl-[(DOTA)-decalysine]2, 30.6±12.0% ID/g at 24 h for chCE7agl-[(DOTA)3-decalysine]2 and 49.9±3.1% ID/g at 48 h for chCE7agl-[(DOTA)5-decalysine)]2. The rapid elimination from the blood of chCE7agl-[(DOTA)-decalysine]2 (1.0±0.1% ID/g at 24 h) is associated with a high liver accumulation (23.2±4.6% ID/g at 24 h). This behavior changed depending on the numbers of DOTA moieties coupled to the decalysine peptide with a slower blood clearance (5.1±1.0 (DOTA)3 versus 11.7±1.4% ID/g (DOTA)5, pDOTA)3 versus 5.8±0.7 (DOTA)5, pDOTA-substituted decalysine ((DOTA)5-decalysine) to an anti-tumor antibody leads to the formation of immunoconjugates with high specific activity and excellent in vivo behavior and is a valuable option for radioimmunotherapy and potentially antibody-drug conjugates (ADCs).
Milholen, William E., II; Jones, Gregory S.; Chan, David T.; Goodliff, Scott L.; Anders, Scott G.; Melton, Latunia P.; Carter, Melissa B.; Allan, Brian G.; Capone, Francis J.
2013-01-01
A second wind tunnel test of the FAST-MAC circulation control model was recently completed in the National Transonic Facility at the NASA Langley Research Center. The model was equipped with four onboard flow control valves allowing independent control of the circulation control plenums, which were directed over a 15% chord simple-hinged flap. The model was configured for low-speed high-lift testing with flap deflections of 30 and 60 degrees, along with the transonic cruise configuration with zero degree flap deflection. Testing was again conducted over a wide range of Mach numbers up to 0.88, and Reynolds numbers up to 30 million based on the mean chord. The first wind tunnel test had poor transonic force and moment data repeatability at mild cryogenic conditions due to inadequate thermal conditioning of the balance. The second test demonstrated that an improvement to the balance heating system significantly improved the transonic data repeatability, but also indicated further improvements are still needed. The low-speed highlift performance of the model was improved by testing various blowing slot heights, and the circulation control was again demonstrated to be effective in re-attaching the flow over the wing at off-design transonic conditions. A new tailored spanwise blowing technique was also demonstrated to be effective at transonic conditions with the benefit of reduced mass flow requirements.
Mehlum, Fridtjof
2012-04-01
The breeding performance of high-arctic bird populations shows large inter-annual variation that may be attributed to environmental variability, such as the timing of snow melt and break-up of the landfast sea ice that surrounds breeding colonies on islands and along coasts. In the Kongsfjorden area (79°N) on Svalbard, the number of breeding pairs and the average egg clutch size vary considerably among years. In this study, data on breeding performance are presented from 15 years in the period 1981-2000. The results showed that early break-up of sea ice in Kongsfjorden resulted in larger numbers of nests and larger average clutch sizes than late break-up. Also, individual islands with early break-up of sea ice in a particular year had more nests and larger clutch sizes compared to other islands surrounded by sea ice during a longer period in spring. Thus, the inter-annual variation in the break-up of sea ice in the fjord has considerable implications for the inter-annual variability of recruitment to the population. The results indicate that the effects of global warming on changes in the sea ice melting regime in coastal regions are important for the reproductive output of island-nesting eiders.
Birla, Bhagyashree S; Chou, Hui-Hsien
2015-01-01
Gene synthesis is frequently used in modern molecular biology research either to create novel genes or to obtain natural genes when the synthesis approach is more flexible and reliable than cloning. DNA chemical synthesis has limits on both its length and yield, thus full-length genes have to be hierarchically constructed from synthesized DNA fragments. Gibson Assembly and its derivatives are the simplest methods to assemble multiple double-stranded DNA fragments. Currently, up to 12 dsDNA fragments can be assembled at once with Gibson Assembly according to its vendor. In practice, the number of dsDNA fragments that can be assembled in a single reaction are much lower. We have developed a rational design method for gene construction that allows high-number dsDNA fragments to be assembled into full-length genes in a single reaction. Using this new design method and a modified version of the Gibson Assembly protocol, we have assembled 3 different genes from up to 45 dsDNA fragments at once. Our design method uses the thermodynamic analysis software Picky that identifies all unique junctions in a gene where consecutive DNA fragments are specifically made to connect to each other. Our novel method is generally applicable to most gene sequences, and can improve both the efficiency and cost of gene assembly.
de Oliveira, Tássia Boeno; Teodoro, Paulo Eduardo; de Alvarenga, Amauri Alves; Bhering, Leonardo Lopes; Campo, Clara Beatriz Hoffmann
2018-01-01
Asian rust affects the physiology of soybean plants and causes losses in yield. Repeatability coefficients may help breeders to know how many measurements are needed to obtain a suitable reliability for a target trait. Therefore, the objectives of this study were to determine the repeatability coefficients of 14 traits in soybean plants inoculated with Phakopsora pachyrhizi and to establish the minimum number of measurements needed to predict the breeding value with high accuracy. Experiments were performed in a 3x2 factorial arrangement with three treatments and two inoculations in a random block design. Repeatability coefficients, coefficients of determination and number of measurements needed to obtain a certain reliability were estimated using ANOVA, principal component analysis based on the covariance matrix and the correlation matrix, structural analysis and mixed model. It was observed that the principal component analysis based on the covariance matrix out-performed other methods for almost all traits. Significant differences were observed for all traits except internal CO2 concentration for the treatment effects. For the measurement effects, all traits were significantly different. In addition, significant differences were found for all Treatment x Measurement interaction traits except coumestrol, chitinase and chlorophyll content. Six measurements were suitable to obtain a coefficient of determination higher than 0.7 for all traits based on principal component analysis. The information obtained from this research will help breeders and physiologists determine exactly how many measurements are needed to evaluate each trait in soybean plants infected by P. pachyrhizi with a desirable reliability. PMID:29438380
Bhagyashree S Birla
Full Text Available Gene synthesis is frequently used in modern molecular biology research either to create novel genes or to obtain natural genes when the synthesis approach is more flexible and reliable than cloning. DNA chemical synthesis has limits on both its length and yield, thus full-length genes have to be hierarchically constructed from synthesized DNA fragments. Gibson Assembly and its derivatives are the simplest methods to assemble multiple double-stranded DNA fragments. Currently, up to 12 dsDNA fragments can be assembled at once with Gibson Assembly according to its vendor. In practice, the number of dsDNA fragments that can be assembled in a single reaction are much lower. We have developed a rational design method for gene construction that allows high-number dsDNA fragments to be assembled into full-length genes in a single reaction. Using this new design method and a modified version of the Gibson Assembly protocol, we have assembled 3 different genes from up to 45 dsDNA fragments at once. Our design method uses the thermodynamic analysis software Picky that identifies all unique junctions in a gene where consecutive DNA fragments are specifically made to connect to each other. Our novel method is generally applicable to most gene sequences, and can improve both the efficiency and cost of gene assembly.
Zita Garate
2015-12-01
Full Text Available Pyruvate kinase deficiency (PKD is a rare erythroid metabolic disease caused by mutations in the PKLR gene. Erythrocytes from PKD patients show an energetic imbalance causing chronic non-spherocytic hemolytic anemia, as pyruvate kinase defects impair ATP production in erythrocytes. We generated PKD induced pluripotent stem cells (PKDiPSCs from peripheral blood mononuclear cells (PB-MNCs of PKD patients by non-integrative Sendai viral vectors. PKDiPSCs were gene edited to integrate a partial codon-optimized R-type pyruvate kinase cDNA in the second intron of the PKLR gene by TALEN-mediated homologous recombination (HR. Notably, we found allele specificity of HR led by the presence of a single-nucleotide polymorphism. High numbers of erythroid cells derived from gene-edited PKDiPSCs showed correction of the energetic imbalance, providing an approach to correct metabolic erythroid diseases and demonstrating the practicality of this approach to generate the large cell numbers required for comprehensive biochemical and metabolic erythroid analyses.
Y. Narita
2011-02-01
Full Text Available A new analysis method is presented that provides a high-resolution power spectrum in a broad wave number domain based on multi-point measurements. The analysis technique is referred to as the Multi-point Signal Resonator (MSR and it benefits from Capon's minimum variance method for obtaining the proper power spectral density of the signal as well as the MUSIC algorithm (Multiple Signal Classification for considerably reducing the noise part in the spectrum. The mathematical foundation of the analysis method is presented and it is applied to synthetic data as well as Cluster observations of the interplanetary magnetic field. Using the MSR technique for Cluster data we find a wave in the solar wind propagating parallel to the mean magnetic field with relatively small amplitude, which is not identified by the Capon spectrum. The Cluster data analysis shows the potential of the MSR technique for studying waves and turbulence using multi-point measurements.
Kujawski, Joseph T.; Gliese, Ulrik B.; Cao, N. T.; Zeuch, M. A.; White, D.; Chornay, D. J; Lobell, J. V.; Avanov, L. A.; Barrie, A. C.; Mariano, A. J.;
2015-01-01
Each half of the Dual Electron Spectrometer (DES) of the Fast Plasma Investigation (FPI) on NASA's Magnetospheric MultiScale (MMS) mission utilizes a microchannel plate Chevron stack feeding 16 separate detection channels each with a dedicated anode and amplifier/discriminator chip. The desire to detect events on a single channel with a temporal spacing of 100 ns and a fixed dead-time drove our decision to use an amplifier/discriminator with a very fast (GHz class) front end. Since the inherent frequency response of each pulse in the output of the DES microchannel plate system also has frequency components above a GHz, this produced a number of design constraints not normally expected in electronic systems operating at peak speeds of 10 MHz. Additional constraints are imposed by the geometry of the instrument requiring all 16 channels along with each anode and amplifier/discriminator to be packaged in a relatively small space. We developed an electrical model for board level interactions between the detector channels to allow us to design a board topology which gave us the best detection sensitivity and lowest channel to channel crosstalk. The amplifier/discriminator output was designed to prevent the outputs from one channel from producing triggers on the inputs of other channels. A number of Radio Frequency design techniques were then applied to prevent signals from other subsystems (e.g. the high voltage power supply, command and data handling board, and Ultraviolet stimulation for the MCP) from generating false events. These techniques enabled us to operate the board at its highest sensitivity when operated in isolation and at very high sensitivity when placed into the overall system.
Effect of pulse repetition rate and number of pulses in the analysis of polypropylene and high density polyethylene by nanosecond infrared laser induced breakdown spectroscopy
Leme, Flavio O. [Laboratorio de Quimica Analitica ' Henrique Bergamin Filho' , Centro de Energia Nuclear na Agricultura, Universidade de Sao Paulo, Av. Centenario 303, 13416-000 Piracicaba, SP (Brazil); Godoi, Quienly [Laboratorio de Quimica Analitica ' Henrique Bergamin Filho' , Centro de Energia Nuclear na Agricultura, Universidade de Sao Paulo, Av. Centenario 303, 13416-000 Piracicaba, SP (Brazil); Departamento de Quimica, Universidade Federal de Sao Carlos, Rod. Washington Luis, km 235, 13565-905 Sao Carlos, SP (Brazil); Kiyataka, Paulo H.M. [Centro de Tecnologia de Embalagens, Instituto de Tecnologia de Alimentos, Av. Brasil 2880, 13070-178 Campinas, SP (Brazil); Santos, Dario [Departamento de Ciencias Exatas e da Terra, Universidade Federal de Sao Paulo, Rua Prof. Artur Riedel 275, 09972-270 Diadema, SP (Brazil); Agnelli, Jose A.M. [Departamento de Engenharia de Materiais, Universidade Federal de Sao Carlos, Rod. Washington Luis, km 235, 13565-905 Sao Carlos, SP (Brazil); and others
2012-02-01
Pulse repetition rates and the number of laser pulses are among the most important parameters that do affect the analysis of solid materials by laser induced breakdown spectroscopy, and the knowledge of their effects is of fundamental importance for suggesting analytical strategies when dealing with laser ablation processes of polymers. In this contribution, the influence of these parameters in the ablated mass and in the features of craters was evaluated in polypropylene and high density polyethylene plates containing pigment-based PbCrO{sub 4}. Surface characterization and craters profile were carried out by perfilometry and scanning electron microscopy. Area, volume and profile of craters were obtained using Taylor Map software. A laser induced breakdown spectroscopy system consisted of a Q-Switched Nd:YAG laser (1064 nm, 5 ns) and an Echelle spectrometer equipped with ICCD detector were used. The evaluated operating conditions consisted of 10, 25 and 50 laser pulses at 1, 5 and 10 Hz, 250 mJ/pulse (85 J cm{sup -2}), 2 {mu}s delay time and 6 {mu}s integration time gate. Differences in the topographical features among craters of both polymers were observed. The decrease in the repetition rate resulted in irregular craters and formation of edges, especially in polypropylene sample. The differences in the topographical features and ablated masses were attributed to the influence of the degree of crystallinity, crystalline melting temperature and glass transition temperature in the ablation process of the high density polyethylene and polypropylene. It was also observed that the intensities of chromium and lead emission signals obtained at 10 Hz were two times higher than at 5 Hz by keeping the number of laser pulses constant.
Weidensteiner, Claudia; Allegrini, Peter R; Sticker-Jantscheff, Melanie; Romanet, Vincent; Ferretti, Stephane; McSheehy, Paul MJ
2014-01-01
Effective chemotherapy rapidly reduces the spin–lattice relaxation of water protons (T 1 ) in solid tumours and this change (ΔT 1 ) often precedes and strongly correlates with the eventual change in tumour volume (TVol). To understand the biological nature of ΔT 1 , we have performed studies in vivo and ex vivo with the allosteric mTOR inhibitor, everolimus. Mice bearing RIF-1 tumours were studied by magnetic resonance imaging (MRI) to determine TVol and T 1 , and MR spectroscopy (MRS) to determine levels of the proliferation marker choline and levels of lipid apoptosis markers, prior to and 5 days (endpoint) after daily treatment with vehicle or everolimus (10 mg/kg). At the endpoint, tumours were ablated and an entire section analysed for cellular and necrotic quantification and staining for the proliferation antigen Ki67 and cleaved-caspase-3 as a measure of apoptosis. The number of blood-vessels (BV) was evaluated by CD31 staining. Mice bearing B16/BL6 melanoma tumours were studied by MRI to determine T 1 under similar everolimus treatment. At the endpoint, cell bioluminescence of the tumours was measured ex vivo. Everolimus blocked RIF-1 tumour growth and significantly reduced tumour T 1 and total choline (Cho) levels, and increased polyunsaturated fatty-acids which are markers of apoptosis. Immunohistochemistry showed that everolimus reduced the %Ki67 + cells but did not affect caspase-3 apoptosis, necrosis, BV-number or cell density. The change in T 1 (ΔT 1 ) correlated strongly with the changes in TVol and Cho and %Ki67 + . In B16/BL6 tumours, everolimus also decreased T 1 and this correlated with cell bioluminescence; another marker of cell viability. Receiver-operating-characteristic curves (ROC) for everolimus on RIF-1 tumours showed that ΔT 1 had very high levels of sensitivity and specificity (ROC AUC = 0.84) and this was confirmed for the cytotoxic patupilone in the same tumour model (ROC AUC = 0.97). These studies suggest that ΔT 1 is not a
Olsen, Jaran S; Aarskaug, Tone; Skogan, Gunnar; Fykse, Else Marie; Ellingsen, Anette Bauer; Blatny, Janet M
2009-09-01
Vibrio cholerae is the etiological agent of cholera and may be used in bioterror actions due to the easiness of its dissemination, and the public fear for acquiring the cholera disease. A simple and highly discriminating method for connecting clinical and environmental isolates of V. cholerae is needed in microbial forensics. Twelve different loci containing variable numbers of tandem-repeats (VNTRs) were evaluated in which six loci were polymorphic. Two multiplex reactions containing PCR primers targeting these six VNTRs resulted in successful DNA amplification of 142 various environmental and clinical V. cholerae isolates. The genetic distribution inside the V. cholerae strain collection was used to evaluate the discriminating power (Simpsons Diversity Index=0.99) of this new MLVA analysis, showing that the assay have a potential to differentiate between various strains, but also to identify those isolates which are collected from a common V. cholerae outbreak. This work has established a rapid and highly discriminating MLVA assay useful for track back analyses and/or forensic studies of V. cholerae infections.
Matthias Bauer
2016-10-01
Full Text Available This paper discusses wind tunnel test results aimed at advancing active flow control technology to increase the aerodynamic efficiency of an aircraft during take-off. A model of the outer section of a representative civil airliner wing was equipped with two-stage fluidic actuators between the slat edge and wing tip, where mechanical high-lift devices fail to integrate. The experiments were conducted at a nominal take-off Mach number of M = 0.2. At this incidence velocity, separation on the wing section, accompanied by increased drag, is triggered by the strong slat edge vortex at high angles of attack. On the basis of global force measurements and local static pressure data, the effect of pulsed blowing on the complex flow is evaluated, considering various momentum coefficients and spanwise distributions of the actuation effort. It is shown that through local intensification of forcing, a momentum coefficient of less than c μ = 0.6 % suffices to offset the stall by 2.4°, increase the maximum lift by more than 10% and reduce the drag by 37% compared to the uncontrolled flow.
Arko, Bryan M.
Design trends for the low-pressure turbine (LPT) section of modern gas turbine engines include increasing the loading per airfoil, which promises a decreased airfoil count resulting in reduced manufacturing and operating costs. Accurate Reynolds-Averaged Navier-Stokes predictions of separated boundary layers and transition to turbulence are needed, as the lack of an economical and reliable computational model has contributed to this high-lift concept not reaching its full potential. Presented here for what is believed to be the first time applied to low-Re computations of high-lift linear cascade simulations is the Abe-Kondoh-Nagano (AKN) linear low-Re two-equation turbulence model which utilizes the Kolmogorov velocity scale for improved predictions of separated boundary layers. A second turbulence model investigated is the Kato-Launder modified version of the AKN, denoted MPAKN, which damps turbulent production in highly strained regions of flow. Fully Laminar solutions have also been calculated in an effort to elucidate the transitional quality of the turbulence model solutions. Time accurate simulations of three modern high-lift blades at a Reynolds number of 25,000 are compared to experimental data and higher-order computations in order to judge the accuracy of the results, where it is shown that the RANS simulations with highly refined grids can produce both quantitatively and qualitatively similar separation behavior as found in experiments. In particular, the MPAKN model is shown to predict the correct boundary layer behavior for all three blades, and evidence of transition is found through inspection of the components of the Reynolds Stress Tensor, spectral analysis, and the turbulence production parameter. Unfortunately, definitively stating that transition is occurring becomes an uncertain task, as similar evidence of the transition process is found in the Laminar predictions. This reveals that boundary layer reattachment may be a result of laminar
Nori Matsunami
Full Text Available Structural variation is thought to play a major etiological role in the development of autism spectrum disorders (ASDs, and numerous studies documenting the relevance of copy number variants (CNVs in ASD have been published since 2006. To determine if large ASD families harbor high-impact CNVs that may have broader impact in the general ASD population, we used the Affymetrix genome-wide human SNP array 6.0 to identify 153 putative autism-specific CNVs present in 55 individuals with ASD from 9 multiplex ASD pedigrees. To evaluate the actual prevalence of these CNVs as well as 185 CNVs reportedly associated with ASD from published studies many of which are insufficiently powered, we designed a custom Illumina array and used it to interrogate these CNVs in 3,000 ASD cases and 6,000 controls. Additional single nucleotide variants (SNVs on the array identified 25 CNVs that we did not detect in our family studies at the standard SNP array resolution. After molecular validation, our results demonstrated that 15 CNVs identified in high-risk ASD families also were found in two or more ASD cases with odds ratios greater than 2.0, strengthening their support as ASD risk variants. In addition, of the 25 CNVs identified using SNV probes on our custom array, 9 also had odds ratios greater than 2.0, suggesting that these CNVs also are ASD risk variants. Eighteen of the validated CNVs have not been reported previously in individuals with ASD and three have only been observed once. Finally, we confirmed the association of 31 of 185 published ASD-associated CNVs in our dataset with odds ratios greater than 2.0, suggesting they may be of clinical relevance in the evaluation of children with ASDs. Taken together, these data provide strong support for the existence and application of high-impact CNVs in the clinical genetic evaluation of children with ASD.
Bhardwaj, Om Parkash; Krishnamurthy, Ketan; Kremer, Florian; Pischinger, Stefan [RWTH Aachen Univ. (Germany). Inst. for Combustion Engines; Berg, Angelika von; Roth, Georg [RWTH Aachen Univ. (Germany). Inst. of Crystallography; Lueers, Bernhard; Kolbeck, Andreas; Koerfer, Thomas [FEV GmbH, Aachen (Germany)
2013-06-01
Motor vehicle emissions have been identified as a major source of particulates. Although the low limits of particulate matter cause a need for a particulate trap in most of the present day diesel engines, the physical and chemical characterization of particles with the measures of size, number, volatility and reactivity etc. is of increasing interest with respect to the regeneration frequency and regeneration efficiency of a particulate trap. Within the Cluster of Excellence ''Tailor-Made Fuels from Biomass (TMFB)'' at RWTH Aachen University, the Institute for Combustion Engines carried out a detailed investigation program to explore the potential of future biofuel candidates for future combustion systems. The experiments for particulate measurements and analysis were conducted on a EURO 6 compliant High Efficiency Diesel Combustion System (HECS) with petroleum based diesel fuel as reference and today's biofuel (i.e. FAME) as well as a potential future biomass derived fuel candidate (i.e. 2-MTHF I DBE), being developed under TMFB approach. Soot samples collected on polycarbonate filters were analyzed using SEM; revealing vital informations regarding particle size distribution. Furthermore, thermophoretic sampling was also performed on copper grids and samples were analyzed using TEM to determine its graphitic micro-structure. In addition, X-Ray diffraction (XRD) measurements were also performed to get further quantitative information regarding crystal lattice parameters and structure of investigated soot. The results indicate more than 90% reduction in the mass and number concentrations of engine out particle emissions using future biomass derived fuel candidate. A good co-relation was observed between TEM micro-structure results and quantitative crystal lattice and structure information obtained from XRD studies, indicating higher reactivity for soot emitted from 2-MTHF/DBE. (orig.)
Pineda, Gina M; Montgomery, Anne H; Thompson, Robyn; Indest, Brooke; Carroll, Marion; Sinha, Sudhir K
2014-11-01
There is a constant need in forensic casework laboratories for an improved way to increase the first-pass success rate of forensic samples. The recent advances in mini STR analysis, SNP, and Alu marker systems have now made it possible to analyze highly compromised samples, yet few tools are available that can simultaneously provide an assessment of quantity, inhibition, and degradation in a sample prior to genotyping. Currently there are several different approaches used for fluorescence-based quantification assays which provide a measure of quantity and inhibition. However, a system which can also assess the extent of degradation in a forensic sample will be a useful tool for DNA analysts. Possessing this information prior to genotyping will allow an analyst to more informatively make downstream decisions for the successful typing of a forensic sample without unnecessarily consuming DNA extract. Real-time PCR provides a reliable method for determining the amount and quality of amplifiable DNA in a biological sample. Alu are Short Interspersed Elements (SINE), approximately 300bp insertions which are distributed throughout the human genome in large copy number. The use of an internal primer to amplify a segment of an Alu element allows for human specificity as well as high sensitivity when compared to a single copy target. The advantage of an Alu system is the presence of a large number (>1000) of fixed insertions in every human genome, which minimizes the individual specific variation possible when using a multi-copy target quantification system. This study utilizes two independent retrotransposon genomic targets to obtain quantification of an 80bp "short" DNA fragment and a 207bp "long" DNA fragment in a degraded DNA sample in the multiplex system InnoQuant™. The ratio of the two quantitation values provides a "Degradation Index", or a qualitative measure of a sample's extent of degradation. The Degradation Index was found to be predictive of the observed loss
Duan, Sibin; Wang, Rongming; Liu, Jingyue
2018-05-01
Catalysis by supported single metal atoms has demonstrated tremendous potential for practical applications due to their unique catalytic properties. Unless they are strongly anchored to the support surfaces, supported single atoms, however, are thermodynamically unstable, which poses a major obstacle for broad applications of single-atom catalysts (SACs). In order to develop strategies to improve the stability of SACs, we need to understand the intrinsic nature of the sintering processes of supported single metal atoms, especially under various gas environments that are relevant to important catalytic reactions. We report on the synthesis of high number density Pt1/Fe2O3 SACs using a facial strong adsorption method and the study of the mobility of these supported Pt single atoms at 250 °C under various gas environments that are relevant to CO oxidation, water–gas shift, and hydrogenation reactions. Under the oxidative gas environment, Fe2O3 supported Pt single atoms are stable even at high temperatures. The presence of either CO or H2 molecules in the gas environment, however, facilitates the movement of the Pt atoms. The strong interaction between CO and Pt weakens the binding between the Pt atoms and the support, facilitating the movement of the Pt single atoms. The dissociation of H2 molecules on the Pt atoms and their subsequent interaction with the oxygen species of the support surfaces dislodge the surface oxygen anchored Pt atoms, resulting in the formation of Pt clusters. The addition of H2O molecules to the CO or H2 significantly accelerates the sintering of the Fe2O3 supported Pt single atoms. An anchoring-site determined sintering mechanism is further proposed, which is related to the metal–support interaction.
Zou, Zhi; Liu, Jianting; Yang, Lifu; Xie, Guishui
2017-01-01
Arabidopsis thaliana SAG12, a senescence-specific gene encoding a cysteine protease, is widely used as a molecular marker for the study of leaf senescence. To date, its potential orthologues have been isolated from several plant species such as Brassica napus and Nicotiana tabacum. However, little information is available in rubber tree (Hevea brasiliensis), a rubber-producing plant of the Euphorbiaceae family. This study presents the identification of SAG12-like genes from the rubber tree genome. Results showed that an unexpected high number of 17 rubber orthologues with a single intron were found, contrasting the single copy with two introns in Arabidopsis. The gene expansion was also observed in another two Euphorbiaceae plants, castor bean (Ricinus communis) and physic nut (Jatropha curcas), both of which contain 8 orthologues. In accordance with no occurrence of recent whole-genome duplication (WGD) events, most duplicates in castor and physic nut were resulted from tandem duplications. In contrast, the duplicated HbSAG12H genes were derived from tandem duplications as well as the recent WGD. Expression analysis showed that most HbSAG12H genes were lowly expressed in examined tissues except for root and male flower. Furthermore, HbSAG12H1 exhibits a strictly senescence-associated expression pattern in rubber tree leaves, and thus can be used as a marker gene for the study of senescence mechanism in Hevea.
Li Bingheng; Lei Yi'an; Zhang Zhenhua
2013-01-01
Two-quasiparticle bands and low-lying excited high-K four-, six-, and eight-quasiparticle bands in the doubly-odd 174,176 Lu are analyzed by using the cranked shell model (CSM) with the pairing correlations treated by a particle-number conserving (PNC) method, in which the blocking effects are taken into account exactly. The proton and neutron Nilsson level schemes for 174,176 Lu are taken from the adjacent odd-A Lu and Hf isotopes, which are adopted to reproduce the experimental bandhead energies of the one-quasiproton and one-quasineutron bands of these odd-A Lu and Hf nuclei, respectively. Once the quasiparticle configurations are determined, the experimental bandhead energies and the moments of inertia of these two- and multi-quasiparticle bands are well reproduced by PNC-CSM calculations. The Coriolis mixing of the low-K (K=|Ω 1 -Ω 2 |) two-quasiparticle band of the Gallagher-Moszkowski doublet with one nucleon in the Ω=1/2 orbital is analyzed. (authors)
Tang, Yifeng; Akhavan, Rayhaneh
2014-11-01
A nested-LES wall-modeling approach for high Reynolds number, wall-bounded turbulence is presented. In this approach, a coarse-grained LES is performed in the full-domain, along with a nested, fine-resolution LES in a minimal flow unit. The coupling between the two domains is achieved by renormalizing the instantaneous LES velocity fields to match the profiles of kinetic energies of components of the mean velocity and velocity fluctuations in both domains to those of the minimal flow unit in the near-wall region, and to those of the full-domain in the outer region. The method is of fixed computational cost, independent of Reτ , in homogenous flows, and is O (Reτ) in strongly non-homogenous flows. The method has been applied to equilibrium turbulent channel flows at 1000 shear-driven, 3D turbulent channel flow at Reτ ~ 2000 . In equilibrium channel flow, the friction coefficient and the one-point turbulence statistics are predicted in agreement with Dean's correlation and available DNS and experimental data. In shear-driven, 3D channel flow, the evolution of turbulence statistics is predicted in agreement with experimental data of Driver & Hebbar (1991) in shear-driven, 3D boundary layer flow.
Qiu-Hong Wan
Full Text Available The Père David's deer is a highly inbred, but recovered, species, making it interesting to consider their adaptive molecular evolution from an immunological perspective. Prior to this study, genomic sequencing was the only method for isolating all functional MHC genes within a certain species. Here, we report a novel protocol for isolating MHC class II loci from a species, and its use to investigate the adaptive evolution of this endangered deer at the level of multi-locus haplotypes. This protocol was designated "HURRAH" based on its various steps and used to estimate the total number of MHC class II loci. We confirmed the validity of this novel protocol in the giant panda and then used it to examine the Père David's deer. Our results revealed that the Père David's deer possesses nine MHC class II loci and therefore has more functional MHC class II loci than the eight genome-sequenced mammals for which full MHC data are currently available. This could potentially account at least in part for the strong survival ability of this species in the face of severe bottlenecking. The results from the HURRAH protocol also revealed that: (1 All of the identified MHC class II loci were monomorphic at their antigen-binding regions, although DRA was dimorphic at its cytoplasmic tail; and (2 these genes constituted two asymmetric functional MHC class II multi-locus haplotypes: DRA1*01 ∼ DRB1 ∼ DRB3 ∼ DQA1 ∼ DQB2 (H1 and DRA1*02 ∼ DRB2 ∼ DRB4 ∼ DQA2 ∼ DQB1 (H2. The latter finding indicates that the current members of the deer species have lost the powerful ancestral MHC class II haplotypes of nine or more loci, and have instead fixed two relatively weak haplotypes containing five genes. As a result, the Père David's deer are currently at risk for increased susceptibility to infectious pathogens.
Bade, Richard; Bijlsma, Lubertus; Miller, Thomas H; Barron, Leon P; Sancho, Juan Vicente; Hernández, Felix
2015-12-15
The recent development of broad-scope high resolution mass spectrometry (HRMS) screening methods has resulted in a much improved capability for new compound identification in environmental samples. However, positive identifications at the ng/L concentration level rely on analytical reference standards for chromatographic retention time (tR) and mass spectral comparisons. Chromatographic tR prediction can play a role in increasing confidence in suspect screening efforts for new compounds in the environment, especially when standards are not available, but reliable methods are lacking. The current work focuses on the development of artificial neural networks (ANNs) for tR prediction in gradient reversed-phase liquid chromatography and applied along with HRMS data to suspect screening of wastewater and environmental surface water samples. Based on a compound tR dataset of >500 compounds, an optimized 4-layer back-propagation multi-layer perceptron model enabled predictions for 85% of all compounds to within 2min of their measured tR for training (n=344) and verification (n=100) datasets. To evaluate the ANN ability for generalization to new data, the model was further tested using 100 randomly selected compounds and revealed 95% prediction accuracy within the 2-minute elution interval. Given the increasing concern on the presence of drug metabolites and other transformation products (TPs) in the aquatic environment, the model was applied along with HRMS data for preliminary identification of pharmaceutically-related compounds in real samples. Examples of compounds where reference standards were subsequently acquired and later confirmed are also presented. To our knowledge, this work presents for the first time, the successful application of an accurate retention time predictor and HRMS data-mining using the largest number of compounds to preliminarily identify new or emerging contaminants in wastewater and surface waters. Copyright © 2015 Elsevier B.V. All rights
Boivin, Vincent; Deschamps-Francoeur, Gabrielle; Couture, Sonia; Nottingham, Ryan M; Bouchard-Bourelle, Philia; Lambowitz, Alan M; Scott, Michelle S; Abou-Elela, Sherif
2018-07-01
Comparing the abundance of one RNA molecule to another is crucial for understanding cellular functions but most sequencing techniques can target only specific subsets of RNA. In this study, we used a new fragmented ribodepleted TGIRT sequencing method that uses a thermostable group II intron reverse transcriptase (TGIRT) to generate a portrait of the human transcriptome depicting the quantitative relationship of all classes of nonribosomal RNA longer than 60 nt. Comparison between different sequencing methods indicated that FRT is more accurate in ranking both mRNA and noncoding RNA than viral reverse transcriptase-based sequencing methods, even those that specifically target these species. Measurements of RNA abundance in different cell lines using this method correlate with biochemical estimates, confirming tRNA as the most abundant nonribosomal RNA biotype. However, the single most abundant transcript is 7SL RNA, a component of the signal recognition particle. S tructured n on c oding RNAs (sncRNAs) associated with the same biological process are expressed at similar levels, with the exception of RNAs with multiple functions like U1 snRNA. In general, sncRNAs forming RNPs are hundreds to thousands of times more abundant than their mRNA counterparts. Surprisingly, only 50 sncRNA genes produce half of the non-rRNA transcripts detected in two different cell lines. Together the results indicate that the human transcriptome is dominated by a small number of highly expressed sncRNAs specializing in functions related to translation and splicing. © 2018 Boivin et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society.
Diniz, Marina Gonçalves; Duarte, Alessandra Pires; Villacis, Rolando A; Guimarães, Bruna V A; Duarte, Luiz Cláudio Pires; Rogatto, Sílvia R; Gomez, Ricardo Santiago; Gomes, Carolina Cavaliéri
2017-05-01
Ameloblastoma (unicystic, UA, or multicystic, MA) is a rare tumor associated with bone destruction and facial deformity. Its malignant counterpart is the ameloblastic carcinoma (AC). The BRAFV600E mutation is highly prevalent in all these tumors subtypes and cannot account for their different clinical behaviors. We assessed copy number alterations (CNAs) and copy-neutral loss of heterozygosity (cnLOH) in UA (n = 2), MA (n = 3), and AC (n = 1) using the CytoScan HD Array (Affymetrix) and the BRAFV600E status. RT-qPCR was applied in four selected genes (B4GALT1, BAG1, PKD1L2, and PPP2R5A) covered by rare alterations, also including three MA and four normal oral tissues. Fifty-seven CNAs and cnLOH were observed in the ameloblastomas and six CNAs in the AC. Seven of the CNAs were rare (six in UA and one in MA), four of them encompassing genes (gains of 7q11.21, 1q32.3, and 9p21.1 and loss of 16q23.2). We found positive correlation between rare CNA gene dosage and the expression of B4GALT1, BAG1, PKD1L2, and PPP2R5A. The AC and 1 UA were BRAF wild-type; however, this UA showed rare genomic alterations encompassing genes associated with RAF/MAPK activation. Ameloblastomas show rare CNAs and cnLOH, presenting a specific genomic profile with no overlapping of the rare alterations among UA, MA, and AC. These genomic changes might play a role in tumor evolution and in BRAFV600E-negative tumors. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Number Sense on the Number Line
Woods, Dawn Marie; Ketterlin Geller, Leanne; Basaraba, Deni
2018-01-01
A strong foundation in early number concepts is critical for students' future success in mathematics. Research suggests that visual representations, like a number line, support students' development of number sense by helping them create a mental representation of the order and magnitude of numbers. In addition, explicitly sequencing instruction…
Johansson, Jens; Christensen, Silas Sverre
2018-01-01
% for strakes of circular cross section. The present paper argues that this height can be reduced for structures where the critical wind velocity for vortex shedding is in the Supercritical Reynolds number regime. The investigations are aimed for suppressing VIV on offshore wind turbine towers during......^5, i.e. in the Supercritical Reynolds number regime. Results indicate that circular strakes with a diameter corresponding to 3% of the mean diameter of the structure can be used to efficiently reduce VIV at Supercritical Reynolds numbers. This suggests that e.g. robes may be used as temporary helical...
Quantum random number generator
Soubusta, Jan; Haderka, Ondrej; Hendrych, Martin
2001-03-01
Since reflection or transmission of a quantum particle on a beamsplitter is inherently random quantum process, a device built on this principle does not suffer from drawbacks of neither pseudo-random computer generators or classical noise sources. Nevertheless, a number of physical conditions necessary for high quality random numbers generation must be satisfied. Luckily, in quantum optics realization they can be well controlled. We present an easy random number generator based on the division of weak light pulses on a beamsplitter. The randomness of the generated bit stream is supported by passing the data through series of 15 statistical test. The device generates at a rate of 109.7 kbit/s.
Halim, Herni; Abdullah, Ramdzani
2014-01-01
HIGHLIGHTS Highway traffic noise is a serious problem in Malaysia Heavy traffic flow highway recorded higher noise level compared to low traffic flow Noise level stabilized at certain number of vehicles on the road i.e above 500 vehicles. Although much research on road traffic noise has found that noise level increase are influenced by driver behavior and source-receiver distance, little attention has been paid to the relationship between noise level and total number of vehicles...
Richardson, Thomas M.
2014-01-01
We introduce the super Patalan numbers, a generalization of the super Catalan numbers in the sense of Gessel, and prove a number of properties analagous to those of the super Catalan numbers. The super Patalan numbers generalize the super Catalan numbers similarly to how the Patalan numbers generalize the Catalan numbers.
Rosato, Marcela; Álvarez, Inés; Nieto Feliner, Gonzalo; Rosselló, Josep A
2017-01-01
The nuclear genome harbours hundreds to several thousand copies of ribosomal DNA. Despite their essential role in cellular ribogenesis few studies have addressed intrapopulation, interpopulation and interspecific levels of rDNA variability in wild plants. Some studies have assessed the extent of rDNA variation at the sequence and copy-number level with large sampling in several species. However, comparable studies on rDNA site number variation in plants, assessed with extensive hierarchical sampling at several levels (individuals, populations, species) are lacking. In exploring the possible causes for ribosomal loci dynamism, we have used the diploid genus Anacyclus (Asteraceae) as a suitable system to examine the evolution of ribosomal loci. To this end, the number and chromosomal position of 45S rDNA sites have been determined in 196 individuals from 47 populations in all Anacyclus species using FISH. The 45S rDNA site-number has been assessed in a significant sample of seed plants, which usually exhibit rather consistent features, except for polyploid plants. In contrast, the level of rDNA site-number variation detected in Anacyclus is outstanding in the context of angiosperms particularly regarding populations of the same species. The number of 45S rDNA sites ranged from four to 11, accounting for 14 karyological ribosomal phenotypes. Our results are not even across species and geographical areas, and show that there is no clear association between the number of 45S rDNA loci and the life cycle in Anacyclus. A single rDNA phenotype was detected in several species, but a more complex pattern that included intra-specific and intra-population polymorphisms was recorded in A. homogamos, A. clavatus and A. valentinus, three weedy species showing large and overlapping distribution ranges. It is likely that part of the cytogenetic changes and inferred dynamism found in these species have been triggered by genomic rearrangements resulting from contemporary
[Intel random number generator-based true random number generator].
Huang, Feng; Shen, Hong
2004-09-01
To establish a true random number generator on the basis of certain Intel chips. The random numbers were acquired by programming using Microsoft Visual C++ 6.0 via register reading from the random number generator (RNG) unit of an Intel 815 chipset-based computer with Intel Security Driver (ISD). We tested the generator with 500 random numbers in NIST FIPS 140-1 and X(2) R-Squared test, and the result showed that the random number it generated satisfied the demand of independence and uniform distribution. We also compared the random numbers generated by Intel RNG-based true random number generator and those from the random number table statistically, by using the same amount of 7500 random numbers in the same value domain, which showed that the SD, SE and CV of Intel RNG-based random number generator were less than those of the random number table. The result of u test of two CVs revealed no significant difference between the two methods. Intel RNG-based random number generator can produce high-quality random numbers with good independence and uniform distribution, and solves some problems with random number table in acquisition of the random numbers.
Mohamed Labib Salem; Mohamed Ramadan El-Shanshory; Nabila Ibrahim El-Desouki; Said Hammad Abdou; Mohamed Attia Attia; Abdel-Aziz Awad Zidan; Shymaa Sobhy Mourad
2015-01-01
Background: Acute lymphoblastic leukemia (ALL) is considered as one of the most common cancer in pediatric malignancies. Among ALL, B-cell Acute Lymphoblastic Leukemia (B-ALL) represents 80% to 85% of the childhood ALL. Problem: Although anti B-ALL chemotherapy kill B-ALL, it associates with alteration in the numbers of CD4+ and CD8+ T-cells, and thus impacts the overall immunity. Aim: To evaluate the impact of anti B-ALL on the numbers of CD4+ and CD8+ T-cells in correlation to the n...
Pérez-Rodríguez, F.; Zwietering, M.H.
2012-01-01
The Central Limit Theorem (CLT) is proposed as a means of understanding microbial risk in foods from a Public Health perspective. One variant of the CLT states that as the number of random variables, each with a finite mean and variance, increases (¿8), the distribution of the sum (or mean) of those
Rinehart, Nicole J.; Bradshaw, John L.; Moss, Simon A.; Brereton, Avril V.; Tonge, Bruce J.
2006-01-01
The repetitive, stereotyped and obsessive behaviours, which are core diagnostic features of autism, are thought to be underpinned by executive dysfunction. This study examined executive impairment in individuals with autism and Asperger's disorder using a verbal equivalent of an established pseudo-random number generating task. Different patterns…
Elementary number theory with programming
Lewinter, Marty
2015-01-01
A successful presentation of the fundamental concepts of number theory and computer programming Bridging an existing gap between mathematics and programming, Elementary Number Theory with Programming provides a unique introduction to elementary number theory with fundamental coverage of computer programming. Written by highly-qualified experts in the fields of computer science and mathematics, the book features accessible coverage for readers with various levels of experience and explores number theory in the context of programming without relying on advanced prerequisite knowledge and con
Earthquake number forecasts testing
Kagan, Yan Y.
2017-10-01
We study the distributions of earthquake numbers in two global earthquake catalogues: Global Centroid-Moment Tensor and Preliminary Determinations of Epicenters. The properties of these distributions are especially required to develop the number test for our forecasts of future seismic activity rate, tested by the Collaboratory for Study of Earthquake Predictability (CSEP). A common assumption, as used in the CSEP tests, is that the numbers are described by the Poisson distribution. It is clear, however, that the Poisson assumption for the earthquake number distribution is incorrect, especially for the catalogues with a lower magnitude threshold. In contrast to the one-parameter Poisson distribution so widely used to describe earthquake occurrences, the negative-binomial distribution (NBD) has two parameters. The second parameter can be used to characterize the clustering or overdispersion of a process. We also introduce and study a more complex three-parameter beta negative-binomial distribution. We investigate the dependence of parameters for both Poisson and NBD distributions on the catalogue magnitude threshold and on temporal subdivision of catalogue duration. First, we study whether the Poisson law can be statistically rejected for various catalogue subdivisions. We find that for most cases of interest, the Poisson distribution can be shown to be rejected statistically at a high significance level in favour of the NBD. Thereafter, we investigate whether these distributions fit the observed distributions of seismicity. For this purpose, we study upper statistical moments of earthquake numbers (skewness and kurtosis) and compare them to the theoretical values for both distributions. Empirical values for the skewness and the kurtosis increase for the smaller magnitude threshold and increase with even greater intensity for small temporal subdivision of catalogues. The Poisson distribution for large rate values approaches the Gaussian law, therefore its skewness
Mansingka, Abhinav S.
2014-06-18
This paper introduces fully digital implementations of four di erent systems in the 3rd order jerk-equation based chaotic family using the Euler approximation. The digitization approach enables controllable chaotic systems that reliably provide sinusoidal or chaotic output based on a selection input. New systems are introduced, derived using logical and arithmetic operations between two system implementations of different bus widths, with up to 100x higher maximum Lyapunov exponent than the original jerkequation based chaotic systems. The resulting chaotic output is shown to pass the NIST sp. 800-22 statistical test suite for pseudorandom number generators without post-processing by only eliminating the statistically defective bits. The systems are designed in Verilog HDL and experimentally verified on a Xilinx Virtex 4 FPGA for a maximum throughput of 15.59 Gbits/s for the native chaotic output and 8.77 Gbits/s for the resulting pseudo-random number generators.
A. Wiedensohler
2012-03-01
Full Text Available Mobility particle size spectrometers often referred to as DMPS (Differential Mobility Particle Sizers or SMPS (Scanning Mobility Particle Sizers have found a wide range of applications in atmospheric aerosol research. However, comparability of measurements conducted world-wide is hampered by lack of generally accepted technical standards and guidelines with respect to the instrumental set-up, measurement mode, data evaluation as well as quality control. Technical standards were developed for a minimum requirement of mobility size spectrometry to perform long-term atmospheric aerosol measurements. Technical recommendations include continuous monitoring of flow rates, temperature, pressure, and relative humidity for the sheath and sample air in the differential mobility analyzer.
We compared commercial and custom-made inversion routines to calculate the particle number size distributions from the measured electrical mobility distribution. All inversion routines are comparable within few per cent uncertainty for a given set of raw data.
Furthermore, this work summarizes the results from several instrument intercomparison workshops conducted within the European infrastructure project EUSAAR (European Supersites for Atmospheric Aerosol Research and ACTRIS (Aerosols, Clouds, and Trace gases Research InfraStructure Network to determine present uncertainties especially of custom-built mobility particle size spectrometers. Under controlled laboratory conditions, the particle number size distributions from 20 to 200 nm determined by mobility particle size spectrometers of different design are within an uncertainty range of around ±10% after correcting internal particle losses, while below and above this size range the discrepancies increased. For particles larger than 200 nm, the uncertainty range increased to 30%, which could not be explained. The network reference mobility spectrometers with identical design agreed within ±4% in the
Jin, Qiushuang; Shi, Qian
2008-01-01
This study investigated the association between sleep deprivation and enrollment in Advanced Placement (AP) and/or college courses among high school students. Approximately 4,000 surveys were distributed, and 2,197 completed surveys were returned from students in Grades 9 to 12 at 15 high schools in Iowa. Findings indicated the majority of high…
Epstein, Ann S.
The Training of Trainers (ToT) Evaluation investigated the efficacy of the High/Scope model for improving the quality of early childhood programs on a national scale. To address this question, the High/Scope Foundation undertook a multimethod evaluation that collected anecdotal records from the consultants and 793 participants in 40 ToT projects,…
Wanscher, Jørgen Bundgaard; Sørensen, Majken Vildrik
2006-01-01
Random numbers are used for a great variety of applications in almost any field of computer and economic sciences today. Examples ranges from stock market forecasting in economics, through stochastic traffic modelling in operations research to photon and ray tracing in graphics. The construction...... distributions into others with most of the required characteristics. In essence, a uniform sequence which is transformed into a new sequence with the required distribution. The subject of this article is to consider the well known highly uniform Halton sequence and modifications to it. The intent is to generate...
Grünberg Jürgen; Jeger Simone; Sarko Dikran; Dennler Patrick; Zimmermann Kurt; Mier Walter; Schibli Roger
2013-01-01
Site-specific enzymatic reactions with microbial transglutaminase (mTGase) lead to a homogenous species of immunoconjugates with a defined ligand/antibody ratio. In the present study, we have investigated the influence of different numbers of 1,4,7,10-tetraazacyclododecane-N-N'-N''-N'''-tetraacetic acid (DOTA) chelats coupled to a decalysine backbone on the in vivo behavior of the chimeric monoclonal anti-L1CAM antibody chCE7agl. The enzymatic conjugation of (DOTA)1-decalysine, (DOTA)3-decaly...
Johakimu, Jonas K
2011-03-01
Full Text Available properties except tear strength: Tensile index (54%), TEA index (104%), Burst index (65%) and sheet density (23%). A tear index decrease (30%) could be attrib- uted to a high proportion of short and fine fibres in the accept stream. The reject stream... gave pulp samples with inferior strength properties with exception of tear strength. This may be due to high proportion of coarse fibres which have limited fibre collapsibility. Poor fibre collapsibility leads to a limited fibre bond- ing ability...
Bodenberger, U.
1981-01-01
The acute radiation syndrome after a single dose of 1600 R (approx. 12-14 Gy in body midline) and after fractionated irradiation with 2400 R (approx. 18-20 Gy) was studied with regard to fractionation time and to the number of bone marrow cells infused. The acute radiation syndrome consisted of damage to the alimentary tract and of damage to the hemopoietic system. Damage of hemopoiesis was reversible in dogs which had been given a sufficient amount of hemopoietic cells. Furthermore changes in skin and in the mucous membranes occurred. Hemopoietic recovery following infusion of various amounts of bone marrow was investigated in dogs which were irradiated with 2400 R within 7 days. Repopulation of bone marrow as well as rise of leukocyte and platelet counts in the peripheral blood was taken as evidence of complete hemopoietic reconstitution. The results indicate that the acute radiation syndrom following 2400 R TBI and autologous BMT can be controlled by fractionation of this dose within 5 or 7 days. The acute gastrointestinal syndrome is aggravated by infusion of a lesser amount of hemopoietic cells. However, TBI with 2400 R does not require greater numbers of hemopoietic cells for restoration of hemopoiesis. Thus, the hemopoiesis supporting tissue can not be damage by this radiation dose to an essential degree. Longterm observations have not revealed serious late defects which could represent a contraindication to the treatment of malignent diseases with 2400 R of TBI. (orig./MG) [de
Number words and number symbols a cultural history of numbers
Menninger, Karl
1992-01-01
Classic study discusses number sequence and language and explores written numerals and computations in many cultures. "The historian of mathematics will find much to interest him here both in the contents and viewpoint, while the casual reader is likely to be intrigued by the author's superior narrative ability.
Sanford, T.W.L.; Mock, R.C.; Marder, B.M. [and others
1997-12-01
A systematic study of annular aluminum-wire z-pinches on the Saturn accelerator shows that the quality of the implosion, (as measured by the radial convergence, the radiated energy, pulse width, and power), increases with wire number. Radiation magnetohydrodynamic (RMHC) xy simulations suggest that the implosion transitions from that of individual wire plasmas to that of a continuous plasma shell when the interwire spacing is reduced below {approximately} 1.4 mm. In this plasma-shell regime, many of the global radiation and plasma characteristics are in agreement with those simulated by 2D-RMHC rz simulations. In this regime, measured changes in the radiation pulse width with variations in load mass and array radius are consistent with the simulations and are explained by the development of 2D fluid motion in the rz plane. Associated variations in the K-shell yield are qualitatively explained by simple radiation-scaling models.
Sanford, T.W.L.; Mock, R.C.; Marder, B.M.
1997-01-01
A systematic study of annular aluminum-wire z-pinches on the Saturn accelerator shows that the quality of the implosion, (as measured by the radial convergence, the radiated energy, pulse width, and power), increases with wire number. Radiation magnetohydrodynamic (RMHC) xy simulations suggest that the implosion transitions from that of individual wire plasmas to that of a continuous plasma shell when the interwire spacing is reduced below ∼ 1.4 mm. In this plasma-shell regime, many of the global radiation and plasma characteristics are in agreement with those simulated by 2D-RMHC rz simulations. In this regime, measured changes in the radiation pulse width with variations in load mass and array radius are consistent with the simulations and are explained by the development of 2D fluid motion in the rz plane. Associated variations in the K-shell yield are qualitatively explained by simple radiation-scaling models
Sanford, T. W. L.; Mock, R. C.; Marder, B. M.; Nash, T. J.; Spielman, R. B.; Peterson, D. L.; Roderick, N. F.; Hammer, J. H.; De Groot, J. S.; Mosher, D.; Whitney, K. G.; Apruzese, J. P.
1997-05-01
A systematic study of annular aluminum-wire z-pinches on the Saturn accelerator shows that the quality of the implosion, (as measured by the radial convergence, the radiated energy, pulse width, and power), increases with wire number. Radiation magnetohydrodynamic (RMHC) xy simulations suggest that the implosion transitions from that of individual wire plasmas to that of a continuous plasma shell when the interwire spacing is reduced below ˜1.4 mm. In this "plasma-shell regime," many of the global radiation and plasma characteristics are in agreement with those simulated by 2D-RMHC rz simulations. In this regime, measured changes in the radiation pulse width with variations in load mass and array radius are consistent with the simulations and are explained by the development of 2D fluid motion in the rz plane. Associated variations in the K-shell yield are qualitatively explained by simple radiation-scaling models.
Sanford, T. W. L.; Mock, R. C.; Marder, B. M.; Nash, T. J.; Spielman, R. B.; Peterson, D. L.; Roderick, N. F.; Hammer, J. H.; De Groot, J. S.; Mosher, D.; Whitney, K. G.; Apruzese, J. P.
1997-01-01
A systematic study of annular aluminum-wire z-pinches on the Saturn accelerator shows that the quality of the implosion, (as measured by the radial convergence, the radiated energy, pulse width, and power), increases with wire number. Radiation magnetohydrodynamic (RMHC) xy simulations suggest that the implosion transitions from that of individual wire plasmas to that of a continuous plasma shell when the interwire spacing is reduced below ∼1.4 mm. In this ''plasma-shell regime,'' many of the global radiation and plasma characteristics are in agreement with those simulated by 2D-RMHC rz simulations. In this regime, measured changes in the radiation pulse width with variations in load mass and array radius are consistent with the simulations and are explained by the development of 2D fluid motion in the rz plane. Associated variations in the K-shell yield are qualitatively explained by simple radiation-scaling models
Carlson, H. W.
1979-01-01
A new linearized-theory pressure-coefficient formulation was studied. The new formulation is intended to provide more accurate estimates of detailed pressure loadings for improved stability analysis and for analysis of critical structural design conditions. The approach is based on the use of oblique-shock and Prandtl-Meyer expansion relationships for accurate representation of the variation of pressures with surface slopes in two-dimensional flow and linearized-theory perturbation velocities for evaluation of local three-dimensional aerodynamic interference effects. The applicability and limitations of the modification to linearized theory are illustrated through comparisons with experimental pressure distributions for delta wings covering a Mach number range from 1.45 to 4.60 and angles of attack from 0 to 25 degrees.
Guanglong Chen
2015-10-01
Full Text Available The supersonic gas jets from conical nozzles are simulated using 2D model. The on-axis atom number density in gas jet is investigated in detail by comparing the simulated densities with the idealized densities of straight streamline model in scaling laws. It is found that the density is generally lower than the idealized one and the deviation between them is mainly dependent on the opening angle of conical nozzle, the nozzle length and the gas backing pressure. The density deviation is then used to discuss the deviation of the equivalent diameter of a conical nozzle from the idealized deq in scaling laws. The investigation on the lateral expansion of gas jet indicates the lateral expansion could be responsible for the behavior of the density deviation. These results could be useful for the estimation of cluster size and the understanding of experimental results in laser-cluster interaction experiments.
B. Sutipnyo
2018-01-01
Full Text Available This research was aimed to determine the increasing of students' motivation that has been applied by Numbered Heads Together (NHT learning model with Science, Environment, Technology, Society (SETS approach. The design of this study was quasi experiment with One Group Pretest-Posttest Design. The data of students’ learning motivation obtained through questionnaire administered before and after NHT learning model with SETS approach. In this research, the indicators of learning-motivation were facing tasks diligently, showing interest in variety of problems, prefering to work independently, keeping students’ opinions, and feeling happy to find and solve problems. Increasing of the students’ learning motivation was analyzed by using a gain test. The results showed that applying NHT learning model with SETS approach could increase the students’ learning motivation in medium categories.
Zotin, J L; Pacheco, M E; Souza, V P; Belato, D; Silva, R M.S. [PETROBRAS, Rio de Janeiro, RJ (Brazil). Centro de Pesquisas (CENPES)
2004-07-01
According to the Brazilian specifications for diesel, lower sulfur content and higher cetane number can be expected in the near future, leading to an increased capacity of hydrotreating processes. PETROBRAS has proved technology for hydrotreating processes with 8 high pressure single stage units in operation. However, the production of ultra low sulfur diesel with high cetane number may require two stages processes, with conventional hydrotreating in the first step and deep aromatic saturation (HDA), with increase in the cetane number, in the second one. In this approach, noble metal catalysts, which are more active for hydrogenation but more sensitive to sulfur and nitrogen poisoning, can be used in the second stage. In the present work, the 2 stages approach was studied for maximizing cetane number of Brazilian gasoils. The influence of operating variables and the inhibition effect by sulfur and nitrogen were analyzed. Diesel with sulfur content below 10 ppm and high aromatic conversions at relatively mild conditions were obtained with noble metal catalysts, with a cetane number increase up to 6 points in the second stage. Sulfur compounds have a stronger inhibition effect than basic nitrogen compounds on hydrogenation reaction rates, but a synergetic effect was observed when both contaminants were present in high concentrations. (author)
We have shown that protein malnutrition during fetal growth followed by postnatal high-fat diets results in a rapid increase in subcutaneous adipose tissue mass in the offspring contributing to development of obesity and insulin resistance. Recent studies have shown that the absence of a key transcr...
Diniz, Marina Gonçalves; Duarte, Alessandra Pires; Villacis, Rolando A
2017-01-01
BACKGROUND: Ameloblastoma (unicystic, UA, or multicystic, MA) is a rare tumor associated with bone destruction and facial deformity. Its malignant counterpart is the ameloblastic carcinoma (AC). The BRAFV600E mutation is highly prevalent in all these tumors subtypes and cannot account for their d...
T. Pathinathan
2015-01-01
Full Text Available In this paper we define diamond fuzzy number with the help of triangular fuzzy number. We include basic arithmetic operations like addition, subtraction of diamond fuzzy numbers with examples. We define diamond fuzzy matrix with some matrix properties. We have defined Nested diamond fuzzy number and Linked diamond fuzzy number. We have further classified Right Linked Diamond Fuzzy number and Left Linked Diamond Fuzzy number. Finally we have verified the arithmetic operations for the above mentioned types of Diamond Fuzzy Numbers.
Koninck, Jean-Marie De
2009-01-01
Who would have thought that listing the positive integers along with their most remarkable properties could end up being such an engaging and stimulating adventure? The author uses this approach to explore elementary and advanced topics in classical number theory. A large variety of numbers are contemplated: Fermat numbers, Mersenne primes, powerful numbers, sublime numbers, Wieferich primes, insolite numbers, Sastry numbers, voracious numbers, to name only a few. The author also presents short proofs of miscellaneous results and constantly challenges the reader with a variety of old and new n
Sanford, T.W.; Mock, R.C.; Marder, B.M.; Nash, T.J.; Spielman, R.B. [Sandia National Laboratories, Albuquerque, New Mexico87185 (United States); Peterson, D.L.; Roderick, N.F. [Los Alamos National Laboratory, Los Alamos, New Mexico87545 (United States); Hammer, J.H.; De Groot, J.S. [Lawrence Livermore National Laboratory, Livermore, California94550 (United States); Mosher, D. [Naval Research Laboratory, Pulsed Power Physics Branch, Washington, District of Columbia20375 (United States); Whitney, K.G.; Apruzese, J.P. [Naval Research Laboratory, Radiation Hydrodynamics Branch, Washington, District of Columbia20375 (United States)
1997-05-01
A systematic study of annular aluminum-wire z-pinches on the Saturn accelerator shows that the quality of the implosion, (as measured by the radial convergence, the radiated energy, pulse width, and power), increases with wire number. Radiation magnetohydrodynamic (RMHC) xy simulations suggest that the implosion transitions from that of individual wire plasmas to that of a continuous plasma shell when the interwire spacing is reduced below {approximately}1.4mm. In this {open_quotes}plasma-shell regime,{close_quotes} many of the global radiation and plasma characteristics are in agreement with those simulated by 2D-RMHC rz simulations. In this regime, measured changes in the radiation pulse width with variations in load mass and array radius are consistent with the simulations and are explained by the development of 2D fluid motion in the rz plane. Associated variations in the K-shell yield are qualitatively explained by simple radiation-scaling models. {copyright} {ital 1997 American Institute of Physics.}
Sanford, T.W.L.; Mock, R.C.; Marder, B.M. [and others
1997-06-01
A systematic study of annular aluminum-wire z-pinches on the Saturn accelerator shows that the quality of the implosion, including the radiated power, increases with wire number. Radiation magnetohydrodynamic (RMEC) xy simulations suggest that the implosion transitions from that of individual wire plasmas to that of a continuous plasma shell when the interwire spacing is reduced below {approximately} 1.4 mm. In the plasma-shell regime, the experimental implosions exhibit 1D- and 2D-code characteristics as evidenced by the presence of a strong first and a weak second radiation pulse that correlates with a strong and weak radial convergence. In this regime, many of the radiation and plasma characteristics are in agreement with those simulated by 2D-RMHC rz simulations. Moreover, measured changes in the radiation pulse width with variations in array mass and radius are consistent with the simulations and are explained by the development of 2D fluid motion in the rz plane. Associated variations in the K-shell yield are qualitatively explained by simple K-shell radiation scaling models.
Sanford, T.W.; Mock, R.C.; Marder, B.M.; Nash, T.J.; Spielman, R.B.; Peterson, D.L.; Roderick, N.F.; Hammer, J.H.; De Groot, J.S.; Mosher, D.; Whitney, K.G.; Apruzese, J.P.
1997-01-01
A systematic study of annular aluminum-wire z-pinches on the Saturn accelerator shows that the quality of the implosion, (as measured by the radial convergence, the radiated energy, pulse width, and power), increases with wire number. Radiation magnetohydrodynamic (RMHC) xy simulations suggest that the implosion transitions from that of individual wire plasmas to that of a continuous plasma shell when the interwire spacing is reduced below ∼1.4mm. In this open-quotes plasma-shell regime,close quotes many of the global radiation and plasma characteristics are in agreement with those simulated by 2D-RMHC rz simulations. In this regime, measured changes in the radiation pulse width with variations in load mass and array radius are consistent with the simulations and are explained by the development of 2D fluid motion in the rz plane. Associated variations in the K-shell yield are qualitatively explained by simple radiation-scaling models. copyright 1997 American Institute of Physics
Niaz Bahadur Khan
Full Text Available This study numerically investigates the vortex-induced vibration (VIV of an elastically mounted rigid cylinder by using Reynolds-averaged Navier-Stokes (RANS equations with computational fluid dynamic (CFD tools. CFD analysis is performed for a fixed-cylinder case with Reynolds number (Re = 104 and for a cylinder that is free to oscillate in the transverse direction and possesses a low mass-damping ratio and Re = 104. Previously, similar studies have been performed with 3-dimensional and comparatively expensive turbulent models. In the current study, the capability and accuracy of the RANS model are validated, and the results of this model are compared with those of detached eddy simulation, direct numerical simulation, and large eddy simulation models. All three response branches and the maximum amplitude are well captured. The 2-dimensional case with the RANS shear-stress transport k-w model, which involves minimal computational cost, is reliable and appropriate for analyzing the characteristics of VIV.
Buchman, Vladimir L; Cooper-Knock, Johnathan; Connor-Robson, Natalie; Higginbottom, Adrian; Kirby, Janine; Razinskaya, Olga D; Ninkina, Natalia; Shaw, Pamela J
2013-04-08
Sizing of GGGGCC hexanucleotide repeat expansions within the C9ORF72 locus, which account for approximately 10% of all amyotrophic lateral sclerosis (ALS) cases, is urgently required to answer fundamental questions about mechanisms of pathogenesis in this important genetic variant. Currently employed PCR protocols are limited to discrimination between the presence and absence of a modified allele with more than 30 copies of the repeat, while Southern hybridisation-based methods are confounded by the somatic heterogeneity commonly present in blood samples, which might cause false-negative or ambiguous results. We describe an optimised Southern hybridisation-based protocol that allows confident detection of the presence of a C9ORF72 repeat expansion alongside independent assessment of its heterogeneity and the number of repeat units. The protocol can be used with either a radiolabeled or non-radiolabeled probe. Using this method we have successfully sized the C9ORF72 repeat expansion in lymphoblastoid cells, peripheral blood, and post-mortem central nervous system (CNS) tissue from ALS patients. It was also possible to confidently demonstrate the presence of repeat expansion, although of different magnitude, in both C9ORF72 alleles of the genome of one patient. The suggested protocol has sufficient advantages to warrant adoption as a standard for Southern blot hybridisation analysis of GGGGCC repeat expansions in the C9ORF72 locus.
On Counting the Rational Numbers
Almada, Carlos
2010-01-01
In this study, we show how to construct a function from the set N of natural numbers that explicitly counts the set Q[superscript +] of all positive rational numbers using a very intuitive approach. The function has the appeal of Cantor's function and it has the advantage that any high school student can understand the main idea at a glance…
Klees, R.; Slobbe, D. C.; Farahani, H. H.
2018-03-01
The posed question arises for instance in regional gravity field modelling using weighted least-squares techniques if the gravity field functionals are synthesised from the spherical harmonic coefficients of a satellite-only global gravity model (GGM), and are used as one of the noisy datasets. The associated noise covariance matrix, appeared to be extremely ill-conditioned with a singular value spectrum that decayed gradually to zero without any noticeable gap. We analysed three methods to deal with the ill-conditioned noise covariance matrix: Tihonov regularisation of the noise covariance matrix in combination with the standard formula for the weighted least-squares estimator, a formula of the weighted least-squares estimator, which does not involve the inverse noise covariance matrix, and an estimator based on Rao's unified theory of least-squares. Our analysis was based on a numerical experiment involving a set of height anomalies synthesised from the GGM GOCO05s, which is provided with a full noise covariance matrix. We showed that the three estimators perform similar, provided that the two regularisation parameters each method knows were chosen properly. As standard regularisation parameter choice rules do not apply here, we suggested a new parameter choice rule, and demonstrated its performance. Using this rule, we found that the differences between the three least-squares estimates were within noise. For the standard formulation of the weighted least-squares estimator with regularised noise covariance matrix, this required an exceptionally strong regularisation, much larger than one expected from the condition number of the noise covariance matrix. The preferred method is the inversion-free formulation of the weighted least-squares estimator, because of its simplicity with respect to the choice of the two regularisation parameters.
Burkhart, Jerry
2009-01-01
Prime numbers are often described as the "building blocks" of natural numbers. This article shows how the author and his students took this idea literally by using prime factorizations to build numbers with blocks. In this activity, students explore many concepts of number theory, including the relationship between greatest common factors and…
Vazzana, Anthony; Garth, David
2007-01-01
One of the oldest branches of mathematics, number theory is a vast field devoted to studying the properties of whole numbers. Offering a flexible format for a one- or two-semester course, Introduction to Number Theory uses worked examples, numerous exercises, and two popular software packages to describe a diverse array of number theory topics.
Smolders, Lotte; Mensink, Ronald P; Plat, Jogchum
2017-04-01
Postprandial responses predict cardiovascular disease risk. However, only a few studies have compared acute postprandial effects of a low-fat, high-carbohydrate (LF) meal with a high-fat, low-carbohydrate (HF) meal. Furthermore, theobromine has favorably affected fasting lipids, but postprandial effects are unknown. Because both fat and theobromine have been reported to increase fasting apolipoprotein A-I (apoA-I) concentrations, the main hypothesis of this randomized, double-blind crossover study was that acute consumption of an HF meal and a theobromine meal increased postprandial apoA-I concentrations, when compared with an LF meal. Theobromine was added to the LF meal. Nine healthy men completed the study. After meal intake, blood was sampled frequently for 4hours. Postprandial apoA-I concentrations were comparable after intake of the 3 meals. Apolipoprotein B48 curves, however, were significantly lower and those of triacylglycerol were significantly higher after HF as compared with LF consumption. Postprandial free fatty acid concentrations decreased less, and glucose and insulin concentrations increased less after HF meal consumption. Except for an increase in the incremental area under the curve for insulin, theobromine did not modify responses of the LF meal. These data show that acute HF and theobromine consumption does not change postprandial apoA-I concentrations. Furthermore, acute HF consumption had divergent effects on postprandial apolipoprotein B48 and triacylglycerol responses, suggesting the formation of less, but larger chylomicrons after HF intake. Finally, except for an increase in the incremental area under the curve for insulin, acute theobromine consumption did not modify the postprandial responses of the LF meal. Copyright © 2017 Elsevier Inc. All rights reserved.
Dou, Zhongwang; Ireland, Peter J.; Bragg, Andrew D.; Liang, Zach; Collins, Lance R.; Meng, Hui
2018-02-01
The radial relative velocity (RV) between particles suspended in turbulent flow plays a critical role in droplet collision and growth. We present a simple and accurate approach to RV measurement in isotropic turbulence—planar 4-frame particle tracking velocimetry—using routine PIV hardware. It improves particle positioning and pairing accuracy over the 2-frame holographic approach by de Jong et al. (Int J Multiphas Flow 36:324-332; de Jong et al., Int J Multiphas Flow 36:324-332, 2010) without using high-speed cameras and lasers as in Saw et al. (Phys Fluids 26:111702, 2014). Homogeneous and isotropic turbulent flow ({R_λ }=357) in a new, fan-driven, truncated iscosahedron chamber was laden with either low-Stokes (mean St=0.09, standard deviation 0.05) or high-Stokes aerosols (mean St=3.46, standard deviation 0.57). For comparison, DNS was conducted under similar conditions ({R_λ }=398; St=0.10 and 3.00, respectively). Experimental RV probability density functions (PDF) and mean inward RV agree well with DNS. Mean inward RV increases with St at small particle separations, r, and decreases with St at large r, indicating the dominance of "path-history" and "inertial filtering" effects, respectively. However, at small r, the experimental mean inward RV trends higher than DNS, possibly due to the slight polydispersity of particles and finite light sheet thickness in experiments. To confirm this interpretation, we performed numerical experiments and found that particle polydispersity increases mean inward RV at small r, while finite laser thickness also overestimates mean inward RV at small r, This study demonstrates the feasibility of accurately measuring RV using routine hardware, and verifies, for the first time, the path-history and inertial filtering effects on particle-pair RV at large particle separations experimentally.
Clasen, Julie; Mellerup, Anders; Olsen, John Elmerdahl
2016-01-01
The primary objective of this study was to determine the minimum number of individual fecal samples to pool together in order to obtain a representative sample for herd level quantification of antimicrobial resistance (AMR) genes in a Danish pig herd, using a novel high-throughput qPCR assay...
On the number of special numbers
without loss of any generality to be the first k primes), then the equation a + b = c has .... This is an elementary exercise in partial summation (see [12]). Thus ... This is easily done by inserting a stronger form of the prime number theorem into the.
Cook, G.R.; Yau, P.; Yasuda, H.; Traut, R.R.; Bradbury, E.M.
1986-01-01
The neighbor relationship of lamb thymus High Mobility Group (HMG) protein 17 to native HeLa nucleosome core particle histones in the reconstituted complex has been studied. 125 I-labeled HMG 17 was cross-linking to core histones using the protein-protein cross-linking reagent 2-iminothiolane. Specific cross-linked products were separated on a two-dimensional Triton-acid-urea/SDS gel system, located by autoradiography, excised and quantified. Disulfide bonds in the cross links were then cleaved and the protein constituents were identified by SDS gel electrophoresis. HMG 17 cross-linked primarily to histone H2A while lower levels of cross-linking occurred between HMG 17 and the other histones. In contrast, cross-linking between two HMG 17 molecules bound on the same nucleosome was relatively rare. It is concluded that the same nucleosome was relatively rare. It is concluded that H2A comprises part of the HMG 17 binding site but that HMG 17 is sufficiently elongated and mobile to permit cross-linking to the other histones and to a second HMG 17 molecule. These results are in agreement with the current model for the structure of the nucleosome and the proposed binding sites for HMG 17
Moes, Timothy R.; Whitmore, Stephen A.; Jordan, Frank L., Jr.
1993-01-01
A nonintrusive airdata-sensing system was calibrated in flight and wind-tunnel experiments to an angle of attack of 70 deg and to angles of sideslip of +/- 15 deg. Flight-calibration data have also been obtained to Mach 1.2. The sensor, known as the flush airdata sensor, was installed on the nosecap of an F-18 aircraft for flight tests and on a full-scale F-18 forebody for wind-tunnel tests. Flight tests occurred at the NASA Dryden Flight Research Facility, Edwards, California, using the F-18 High Alpha Research Vehicle. Wind-tunnel tests were conducted in the 30- by 60-ft wind tunnel at the NASA LaRC, Hampton, Virginia. The sensor consisted of 23 flush-mounted pressure ports arranged in concentric circles and located within 1.75 in. of the tip of the nosecap. An overdetermined mathematical model was used to relate the pressure measurements to the local airdata quantities. The mathematical model was based on potential flow over a sphere and was empirically adjusted based on flight and wind-tunnel data. For quasi-steady maneuvering, the mathematical model worked well throughout the subsonic, transonic, and low supersonic flight regimes. The model also worked well throughout the angle-of-attack and sideslip regions studied.
Laminar forced convective/conductive heat transfer by finite element method
Kushwaha, H.S.; Kakodkar, A.
1982-01-01
The present study is directed at developing a finite element computer program for solution of decoupled convective/conductive heat transfer problems. Penalty function formulation has been used to solve momentum equations and subsequently transient energy equation is solved using modified Crank-Nicolson method. The optimal upwinding scheme has been employed in energy equation to remove oscillations at high Peclet number. (author)
Klobukowska, H J; Munday, J S
2016-11-01
Cancer-associated fibroblasts (CAFs) are fibroblastic cells that express α-smooth muscle actin and have been identified in the stroma of numerous epithelial tumors. The presence of CAFs within the tumor stroma has been associated with a poorer prognosis in some human cancers, including oral squamous cell carcinomas (SCCs). Cats frequently develop oral SCCs, and although these are generally highly aggressive neoplasms, there is currently a lack of prognostic markers for these tumors. The authors investigated the prognostic value of the presence of CAFs within the stroma of oral SCC biopsy specimens from 47 cats. In addition, several epidemiologic, clinical, and histologic variables were also assessed for prognostic significance. A CAF-positive stroma was identified in 35 of 47 SCCs (74.5%), and the median survival time (ST) of cats with CAF-positive SCCs (35 days) was significantly shorter than that of cats with CAF-negative SCCs (48.5 days) (P = .031). ST was also associated with the location of the primary tumor (P = .0018): the median ST for oropharyngeal SCCs (179 days) was significantly longer than for maxillary (43.5 days; P = .047), mandibular (42 days; P = .022), and sublingual SCCs (22.5 days; P = .0005). The median ST of sublingual SCCs was also shorter compared with maxillary SCCs (P = .0017). Furthermore, a significant association was identified between site and the presence of stromal CAFs (P = .025). On the basis of this retrospective study, evaluating the tumor stroma for CAFs in feline oral SCC biopsy specimens may be of potential prognostic value. © The Author(s) 2016.
Grešak, Rozalija
2015-01-01
The field of real numbers is usually constructed using Dedekind cuts. In these thesis we focus on the construction of the field of real numbers using metric completion of rational numbers using Cauchy sequences. In a similar manner we construct the field of p-adic numbers, describe some of their basic and topological properties. We follow by a construction of complex p-adic numbers and we compare them with the ordinary complex numbers. We conclude the thesis by giving a motivation for the int...
On the number of special numbers
We now apply the theory of the Thue equation to obtain an effective bound on m. Indeed, by Lemma 3.2, we can write m2 = ba3 and m2 − 4 = cd3 with b, c cubefree. By the above, both b, c are bounded since they are cubefree and all their prime factors are less than e63727. Now we have a finite number of. Thue equations:.
Kaneko, K.
1987-01-01
A relationship between the number projection and the shell model methods is investigated in the case of a single-j shell. We can find a one-to-one correspondence between the number projected and the shell model states
Gallistel, C R
2017-12-01
The representation of discrete and continuous quantities appears to be ancient and pervasive in animal brains. Because numbers are the natural carriers of these representations, we may discover that in brains, it's numbers all the way down.
Andersen, Torben
2014-01-01
had a marked singular and an unmarked plural. Synchronically, however, the singular is arguably the basic member of the number category as revealed by the use of the two numbers. In addition, some nouns have a collective form, which is grammatically singular. Number also plays a role...
Elvik, Rune; Bjørnskau, Torkel
2017-01-01
Highlights •26 studies of the safety-in-numbers effect are reviewed. •The existence of a safety-in-numbers effect is confirmed. •Results are consistent. •Causes of the safety-in-numbers effect are incompletely known....
de Mestre, Neville
2008-01-01
Prime numbers are important as the building blocks for the set of all natural numbers, because prime factorisation is an important and useful property of all natural numbers. Students can discover them by using the method known as the Sieve of Eratosthenes, named after the Greek geographer and astronomer who lived from c. 276-194 BC. Eratosthenes…
Random number generation and creativity.
Bains, William
2008-01-01
A previous paper suggested that humans can generate genuinely random numbers. I tested this hypothesis by repeating the experiment with a larger number of highly numerate subjects, asking them to call out a sequence of digits selected from 0 through 9. The resulting sequences were substantially non-random, with an excess of sequential pairs of numbers and a deficit of repeats of the same number, in line with previous literature. However, the previous literature suggests that humans generate random numbers with substantial conscious effort, and distractions which reduce that effort reduce the randomness of the numbers. I reduced my subjects' concentration by asking them to call out in another language, and with alcohol - neither affected the randomness of their responses. This suggests that the ability to generate random numbers is a 'basic' function of the human mind, even if those numbers are not mathematically 'random'. I hypothesise that there is a 'creativity' mechanism, while not truly random, provides novelty as part of the mind's defence against closed programming loops, and that testing for the effects seen here in people more or less familiar with numbers or with spontaneous creativity could identify more features of this process. It is possible that training to perform better at simple random generation tasks could help to increase creativity, through training people to reduce the conscious mind's suppression of the 'spontaneous', creative response to new questions.
Ornela De Gasperin
Full Text Available Parents have a limited amount of resources to invest in reproduction and commonly trade-off how much they invest in offspring size (or quality versus brood size. A negative relationship between offspring size and number has been shown in numerous taxa and it underpins evolutionary conflicts of interest between parents and their young. For example, previous work on vertebrates shows that selection favours mothers that produce more offspring, at the expense of individual offspring size, yet favours offspring that have relatively few siblings and therefore attain a greater size at independence. Here we analyse how this trade-off is temporarily affected by stochastic variation in the intensity of interspecific interactions. We examined the effect of the mite Poecilochirus carabi on the relationship between offspring size and number in the burying beetle, Nicrophorus vespilloides. We manipulated the initial number of mites in the reproductive event (by introducing either no mites, 4 mites, 10 mites, or 16 mites, and assessed the effect on the brood. We found a similar trade-off between offspring size and number in all treatments, except in the '16 mite' treatment where the correlation between offspring number and size flattened considerably. This effect arose because larvae in small broods failed to attain a high mass by dispersal. Our results show that variation in the intensity of interspecific interactions can temporarily change the strength of the trade-off between offspring size and number. In this study, high densities of mites prevented individual offspring from attaining their optimal weight, thus potentially temporarily biasing the outcome of parent-offspring conflict in favour of parents.
De Gasperin, Ornela; Kilner, Rebecca M
2016-01-01
Parents have a limited amount of resources to invest in reproduction and commonly trade-off how much they invest in offspring size (or quality) versus brood size. A negative relationship between offspring size and number has been shown in numerous taxa and it underpins evolutionary conflicts of interest between parents and their young. For example, previous work on vertebrates shows that selection favours mothers that produce more offspring, at the expense of individual offspring size, yet favours offspring that have relatively few siblings and therefore attain a greater size at independence. Here we analyse how this trade-off is temporarily affected by stochastic variation in the intensity of interspecific interactions. We examined the effect of the mite Poecilochirus carabi on the relationship between offspring size and number in the burying beetle, Nicrophorus vespilloides. We manipulated the initial number of mites in the reproductive event (by introducing either no mites, 4 mites, 10 mites, or 16 mites), and assessed the effect on the brood. We found a similar trade-off between offspring size and number in all treatments, except in the '16 mite' treatment where the correlation between offspring number and size flattened considerably. This effect arose because larvae in small broods failed to attain a high mass by dispersal. Our results show that variation in the intensity of interspecific interactions can temporarily change the strength of the trade-off between offspring size and number. In this study, high densities of mites prevented individual offspring from attaining their optimal weight, thus potentially temporarily biasing the outcome of parent-offspring conflict in favour of parents.
Todorov, T.D.
1980-01-01
The set of asymptotic numbers A as a system of generalized numbers including the system of real numbers R, as well as infinitely small (infinitesimals) and infinitely large numbers, is introduced. The detailed algebraic properties of A, which are unusual as compared with the known algebraic structures, are studied. It is proved that the set of asymptotic numbers A cannot be isomorphically embedded as a subspace in any group, ring or field, but some particular subsets of asymptotic numbers are shown to be groups, rings, and fields. The algebraic operation, additive and multiplicative forms, and the algebraic properties are constructed in an appropriate way. It is shown that the asymptotic numbers give rise to a new type of generalized functions quite analogous to the distributions of Schwartz allowing, however, the operation multiplication. A possible application of these functions to quantum theory is discussed
Niederreiter, Harald
2015-01-01
This textbook effectively builds a bridge from basic number theory to recent advances in applied number theory. It presents the first unified account of the four major areas of application where number theory plays a fundamental role, namely cryptography, coding theory, quasi-Monte Carlo methods, and pseudorandom number generation, allowing the authors to delineate the manifold links and interrelations between these areas. Number theory, which Carl-Friedrich Gauss famously dubbed the queen of mathematics, has always been considered a very beautiful field of mathematics, producing lovely results and elegant proofs. While only very few real-life applications were known in the past, today number theory can be found in everyday life: in supermarket bar code scanners, in our cars’ GPS systems, in online banking, etc. Starting with a brief introductory course on number theory in Chapter 1, which makes the book more accessible for undergraduates, the authors describe the four main application areas in Chapters...
Chiva-Blanch, Gemma; Condines, Ximena; Magraner, Emma; Roth, Irene; Valderas-Martínez, Palmira; Arranz, Sara; Casas, Rosa; Martínez-Huélamo, Miriam; Vallverdú-Queralt, Anna; Quifer-Rada, Paola; Lamuela-Raventos, Rosa M; Estruch, Ramon
2014-04-01
Moderate alcohol consumption is associated with a decrease in cardiovascular risk, but fermented beverages seem to confer greater cardiovascular protection due to their polyphenolic content. Circulating endothelial progenitor cells (EPC) are bone-marrow-derived stem cells with the ability to repair and maintain endothelial integrity and function and are considered as a surrogate marker of vascular function and cumulative cardiovascular risk. Nevertheless, no study has been carried out on the effects of moderate beer consumption on the number of circulating EPC in high cardiovascular risk patients. To compare the effects of moderate consumption of beer, non-alcoholic beer and gin on the number of circulating EPC and EPC-mobilizing factors. In this crossover trial, 33 men at high cardiovascular risk were randomized to receive beer (30 g alcohol/d), the equivalent amount of polyphenols in the form of non-alcoholic beer, or gin (30 g alcohol/d) for 4 weeks. Diet and physical exercise were carefully monitored. The number of circulating EPC and EPC-mobilizing factors were determined at baseline and after each intervention. After the beer and non-alcoholic beer interventions, the number of circulating EPC significantly increased by 8 and 5 units, respectively, while no significant differences were observed after the gin period. In correlation, stromal cell derived factor 1 increased significantly after the non-alcoholic and the beer interventions. The non-alcoholic fraction of beer increases the number of circulating EPC in peripheral blood from high cardiovascular risk subjects. http://www.controlled-trials.com/ISRCTN95345245 ISRCTN95345245. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.
Population dynamics at high Reynolds number
Perlekar, P.; Benzi, R.; Nelson, D.R.; Toschi, F.
2010-01-01
We study the statistical properties of population dynamics evolving in a realistic two-dimensional compressible turbulent velocity field. We show that the interplay between turbulent dynamics and population growth and saturation leads to quasi-localization and a remarkable reduction in the carrying
High Reynolds Number Liquid Flow Measurements
1988-08-01
25. .n Fig. 25, the dotted line represents data taken from Eckelmann’s study in the thick viscous sublaver of an oil channel. Scatter in the...measurements of the fundamental physical quantities are not only an essencial part in an understanding of multiphase flows but also in the measurement process...technique. One of the most yloei’ used techniques, however, is some form of flow visualization. This includes the use o: tufts, oil paint films
Effects of High Power Lasers, Number 4
1974-10-31
KhMM FMiM FTP FTT FZh GiA GiK IAN Arm IAN Az Avtomatika i tclctnukhanika Acta physica polonica Akadcmiya na,uk Armyanskoy SSR. Doklady...obraztsy, tovarnyye znaki Postepy firyki Physics abstracts Prikladnaya mekhanikö Prikladnaya matcmatika i mckhanika Physica status solidi Pribory i
Jørgensen, Claus Bjørn; Suetens, Sigrid; Tyran, Jean-Robert
numbers based on recent drawings. While most players pick the same set of numbers week after week without regards of numbers drawn or anything else, we find that those who do change, act on average in the way predicted by the law of small numbers as formalized in recent behavioral theory. In particular......We investigate the “law of small numbers” using a unique panel data set on lotto gambling. Because we can track individual players over time, we can measure how they react to outcomes of recent lotto drawings. We can therefore test whether they behave as if they believe they can predict lotto......, on average they move away from numbers that have recently been drawn, as suggested by the “gambler’s fallacy”, and move toward numbers that are on streak, i.e. have been drawn several weeks in a row, consistent with the “hot hand fallacy”....
Ore, Oystein
2017-01-01
Number theory is the branch of mathematics concerned with the counting numbers, 1, 2, 3, … and their multiples and factors. Of particular importance are odd and even numbers, squares and cubes, and prime numbers. But in spite of their simplicity, you will meet a multitude of topics in this book: magic squares, cryptarithms, finding the day of the week for a given date, constructing regular polygons, pythagorean triples, and many more. In this revised edition, John Watkins and Robin Wilson have updated the text to bring it in line with contemporary developments. They have added new material on Fermat's Last Theorem, the role of computers in number theory, and the use of number theory in cryptography, and have made numerous minor changes in the presentation and layout of the text and the exercises.
Ingelhart, Louis E.
According to this reference manual, the nation's courts offer public high school journalists the same constitutional protection for expression, free speech, and free press as adults. Part 1 traces the development of the First and Fourth Amendments and explains how these provisions apply to high school publications. Part 2 examines expression that…
Godefroy, Gilles
2004-01-01
Numbers are fascinating. The fascination begins in childhood, when we first learn to count. It continues as we learn arithmetic, algebra, geometry, and so on. Eventually, we learn that numbers not only help us to measure the world, but also to understand it and, to some extent, to control it. In The Adventure of Numbers, Gilles Godefroy follows the thread of our expanding understanding of numbers to lead us through the history of mathematics. His goal is to share the joy of discovering and understanding this great adventure of the mind. The development of mathematics has been punctuated by a n
Suetens, Sigrid; Galbo-Jørgensen, Claus B.; Tyran, Jean-Robert Karl
2016-01-01
We investigate the ‘law of small numbers’ using a data set on lotto gambling that allows us to measure players’ reactions to draws. While most players pick the same set of numbers week after week, we find that those who do change react on average as predicted by the law of small numbers...... as formalized in recent behavioral theory. In particular, players tend to bet less on numbers that have been drawn in the preceding week, as suggested by the ‘gambler’s fallacy’, and bet more on a number if it was frequently drawn in the recent past, consistent with the ‘hot-hand fallacy’....
Diamond, Harold G; Cheung, Man Ping
2016-01-01
"Generalized numbers" is a multiplicative structure introduced by A. Beurling to study how independent prime number theory is from the additivity of the natural numbers. The results and techniques of this theory apply to other systems having the character of prime numbers and integers; for example, it is used in the study of the prime number theorem (PNT) for ideals of algebraic number fields. Using both analytic and elementary methods, this book presents many old and new theorems, including several of the authors' results, and many examples of extremal behavior of g-number systems. Also, the authors give detailed accounts of the L^2 PNT theorem of J. P. Kahane and of the example created with H. L. Montgomery, showing that additive structure is needed for proving the Riemann hypothesis. Other interesting topics discussed are propositions "equivalent" to the PNT, the role of multiplicative convolution and Chebyshev's prime number formula for g-numbers, and how Beurling theory provides an interpretation of the ...
Intuitive numbers guide decisions
Ellen Peters
2008-12-01
Full Text Available Measuring reaction times to number comparisons is thought to reveal a processing stage in elementary numerical cognition linked to internal, imprecise representations of number magnitudes. These intuitive representations of the mental number line have been demonstrated across species and human development but have been little explored in decision making. This paper develops and tests hypotheses about the influence of such evolutionarily ancient, intuitive numbers on human decisions. We demonstrate that individuals with more precise mental-number-line representations are higher in numeracy (number skills consistent with previous research with children. Individuals with more precise representations (compared to those with less precise representations also were more likely to choose larger, later amounts over smaller, immediate amounts, particularly with a larger proportional difference between the two monetary outcomes. In addition, they were more likely to choose an option with a larger proportional but smaller absolute difference compared to those with less precise representations. These results are consistent with intuitive number representations underlying: a perceived differences between numbers, b the extent to which proportional differences are weighed in decisions, and, ultimately, c the valuation of decision options. Human decision processes involving numbers important to health and financial matters may be rooted in elementary, biological processes shared with other species.
Hirst, Keith
1994-01-01
Number and geometry are the foundations upon which mathematics has been built over some 3000 years. This book is concerned with the logical foundations of number systems from integers to complex numbers. The author has chosen to develop the ideas by illustrating the techniques used throughout mathematics rather than using a self-contained logical treatise. The idea of proof has been emphasised, as has the illustration of concepts from a graphical, numerical and algebraic point of view. Having laid the foundations of the number system, the author has then turned to the analysis of infinite proc
Templates, Numbers & Watercolors.
Clemesha, David J.
1990-01-01
Describes how a second-grade class used large templates to draw and paint five-digit numbers. The lesson integrated artistic knowledge and vocabulary with their mathematics lesson in place value. Students learned how draftspeople use templates, and they studied number paintings by Charles Demuth and Jasper Johns. (KM)
Parrell, H.; Gamble, J. D.
1977-01-01
Transonic Wind Tunnel tests were run on a .015 scale model of the space shuttle orbiter vehicle in the 8-foot transonic wind tunnel. Purpose of the test program was to obtain basic shuttle aerodynamic data through a full range of elevon and aileron deflections, verification of data obtained at other facilities, and effects of Reynolds number. Tests were performed at Mach numbers from .35 to 1.20 and Reynolds numbers from 3,500,000 to 8,200,000 per foot. The high Reynolds number conditions (nominal 8,000,000/foot) were obtained using the ejector augmentation system. Angle of attack was varied from -2 to +20 degrees at sideslip angles of -2, 0, and +2 degrees. Sideslip was varied from -6 to +8 degrees at constant angles of attack from 0 to +20 degrees. Aileron settings were varied from -5 to +10 degrees at elevon deflections of -10, 0, and +10 degrees. Fixed aileron settings of 0 and 2 degrees in combination with various fixed elevon settings between -20 and +5 degrees were also run at varying angles of attack.
Women In Numbers - Europe workshop
Bucur, Alina; Feigon, Brooke; Schneps, Leila
2015-01-01
Covering topics in graph theory, L-functions, p-adic geometry, Galois representations, elliptic fibrations, genus 3 curves and bad reduction, harmonic analysis, symplectic groups and mould combinatorics, this volume presents a collection of papers covering a wide swath of number theory emerging from the third iteration of the international Women in Numbers conference, “Women in Numbers - Europe” (WINE), held on October 14–18, 2013 at the CIRM-Luminy mathematical conference center in France. While containing contributions covering a wide range of cutting-edge topics in number theory, the volume emphasizes those concrete approaches that make it possible for graduate students and postdocs to begin work immediately on research problems even in highly complex subjects.
Ali, Syed A; Chew, Yik Wei
2015-01-01
Antibiotic resistance genes and antibiotics are frequently used to maintain plasmid vectors in bacterial hosts such as Escherichia coli. Due to the risk of spread of antibiotic resistance, the regulatory authorities discourage the use of antibiotic resistance genes/antibiotics for the maintenance of plasmid vectors in certain biotechnology applications. Overexpression of E. coli endogenous fabI gene and subsequent selection on Triclosan has been proposed as a practical alternative to traditional antibiotic selection systems. Unfortunately, overexpression of fabI cannot be used to select medium-copy number plasmids, typically used for the expression of heterologous proteins in E. coli. Here we report that Vibrio cholera FabV, a functional homologue of E. coli FabI, can be used as a suitable marker for the selection and maintenance of both high and medium-copy number plasmid vectors in E. coli.
Coveyou, R.R.
1974-01-01
The subject of random number generation is currently controversial. Differing opinions on this subject seem to stem from implicit or explicit differences in philosophy; in particular, from differing ideas concerning the role of probability in the real world of physical processes, electronic computers, and Monte Carlo calculations. An attempt is made here to reconcile these views. The role of stochastic ideas in mathematical models is discussed. In illustration of these ideas, a mathematical model of the use of random number generators in Monte Carlo calculations is constructed. This model is used to set up criteria for the comparison and evaluation of random number generators. (U.S.)
Weiss, Edwin
1998-01-01
Careful organization and clear, detailed proofs characterize this methodical, self-contained exposition of basic results of classical algebraic number theory from a relatively modem point of view. This volume presents most of the number-theoretic prerequisites for a study of either class field theory (as formulated by Artin and Tate) or the contemporary treatment of analytical questions (as found, for example, in Tate's thesis).Although concerned exclusively with algebraic number fields, this treatment features axiomatic formulations with a considerable range of applications. Modem abstract te
Cohn, Harvey
1980-01-01
""A very stimulating book ... in a class by itself."" - American Mathematical MonthlyAdvanced students, mathematicians and number theorists will welcome this stimulating treatment of advanced number theory, which approaches the complex topic of algebraic number theory from a historical standpoint, taking pains to show the reader how concepts, definitions and theories have evolved during the last two centuries. Moreover, the book abounds with numerical examples and more concrete, specific theorems than are found in most contemporary treatments of the subject.The book is divided into three parts
Crossley, John N
1987-01-01
This book presents detailed studies of the development of three kinds of number. In the first part the development of the natural numbers from Stone-Age times right up to the present day is examined not only from the point of view of pure history but also taking into account archaeological, anthropological and linguistic evidence. The dramatic change caused by the introduction of logical theories of number in the 19th century is also treated and this part ends with a non-technical account of the very latest developments in the area of Gödel's theorem. The second part is concerned with the deve
Professor Stewart's incredible numbers
Stewart, Ian
2015-01-01
Ian Stewart explores the astonishing properties of numbers from 1 to10 to zero and infinity, including one figure that, if you wrote it out, would span the universe. He looks at every kind of number you can think of - real, imaginary, rational, irrational, positive and negative - along with several you might have thought you couldn't think of. He explains the insights of the ancient mathematicians, shows how numbers have evolved through the ages, and reveals the way numerical theory enables everyday life. Under Professor Stewart's guidance you will discover the mathematics of codes,
LeVeque, William J
1996-01-01
This excellent textbook introduces the basics of number theory, incorporating the language of abstract algebra. A knowledge of such algebraic concepts as group, ring, field, and domain is not assumed, however; all terms are defined and examples are given - making the book self-contained in this respect.The author begins with an introductory chapter on number theory and its early history. Subsequent chapters deal with unique factorization and the GCD, quadratic residues, number-theoretic functions and the distribution of primes, sums of squares, quadratic equations and quadratic fields, diopha
Kneusel, Ronald T
2015-01-01
This is a book about numbers and how those numbers are represented in and operated on by computers. It is crucial that developers understand this area because the numerical operations allowed by computers, and the limitations of those operations, especially in the area of floating point math, affect virtually everything people try to do with computers. This book aims to fill this gap by exploring, in sufficient but not overwhelming detail, just what it is that computers do with numbers. Divided into two parts, the first deals with standard representations of integers and floating point numb
Sierpinski, Waclaw
1988-01-01
Since the publication of the first edition of this work, considerable progress has been made in many of the questions examined. This edition has been updated and enlarged, and the bibliography has been revised.The variety of topics covered here includes divisibility, diophantine equations, prime numbers (especially Mersenne and Fermat primes), the basic arithmetic functions, congruences, the quadratic reciprocity law, expansion of real numbers into decimal fractions, decomposition of integers into sums of powers, some other problems of the additive theory of numbers and the theory of Gaussian
R. A. Mollin
1986-01-01
Full Text Available A powerful number is a positive integer n satisfying the property that p2 divides n whenever the prime p divides n; i.e., in the canonical prime decomposition of n, no prime appears with exponent 1. In [1], S.W. Golomb introduced and studied such numbers. In particular, he asked whether (25,27 is the only pair of consecutive odd powerful numbers. This question was settled in [2] by W.A. Sentance who gave necessary and sufficient conditions for the existence of such pairs. The first result of this paper is to provide a generalization of Sentance's result by giving necessary and sufficient conditions for the existence of pairs of powerful numbers spaced evenly apart. This result leads us naturally to consider integers which are representable as a proper difference of two powerful numbers, i.e. n=p1−p2 where p1 and p2 are powerful numbers with g.c.d. (p1,p2=1. Golomb (op.cit. conjectured that 6 is not a proper difference of two powerful numbers, and that there are infinitely many numbers which cannot be represented as a proper difference of two powerful numbers. The antithesis of this conjecture was proved by W.L. McDaniel [3] who verified that every non-zero integer is in fact a proper difference of two powerful numbers in infinitely many ways. McDaniel's proof is essentially an existence proof. The second result of this paper is a simpler proof of McDaniel's result as well as an effective algorithm (in the proof for explicitly determining infinitely many such representations. However, in both our proof and McDaniel's proof one of the powerful numbers is almost always a perfect square (namely one is always a perfect square when n≢2(mod4. We provide in §2 a proof that all even integers are representable in infinitely many ways as a proper nonsquare difference; i.e., proper difference of two powerful numbers neither of which is a perfect square. This, in conjunction with the odd case in [4], shows that every integer is representable in
Corry, Leo
2015-01-01
The world around us is saturated with numbers. They are a fundamental pillar of our modern society, and accepted and used with hardly a second thought. But how did this state of affairs come to be? In this book, Leo Corry tells the story behind the idea of number from the early days of the Pythagoreans, up until the turn of the twentieth century. He presents an overview of how numbers were handled and conceived in classical Greek mathematics, in the mathematics of Islam, in European mathematics of the middle ages and the Renaissance, during the scientific revolution, all the way through to the
Dudley, Underwood
2008-01-01
Ideal for a first course in number theory, this lively, engaging text requires only a familiarity with elementary algebra and the properties of real numbers. Author Underwood Dudley, who has written a series of popular mathematics books, maintains that the best way to learn mathematics is by solving problems. In keeping with this philosophy, the text includes nearly 1,000 exercises and problems-some computational and some classical, many original, and some with complete solutions. The opening chapters offer sound explanations of the basics of elementary number theory and develop the fundamenta
Carpenter, James C.; Fraser, Kathryn M.
Presented are 17 activities designed to supplement junior or senior high school studies in prehistory and archaeology. Stressed throughout the manual is the changing relationship between humans and the environment. The learning experiences fall into three categories: (1) how we study prehistoric cultures, (2) how prehistoric peoples lived, and (3)…
OLUWOLE
Agro-Science Journal of Tropical Agriculture, Food, Environment and Extension. Volume 9 Number 1 ... of persistent dumping of cheap subsidized food imports from developed ... independence of the inefficiency effects in the two estimation ...
Quantum random number generator
Pooser, Raphael C.
2016-05-10
A quantum random number generator (QRNG) and a photon generator for a QRNG are provided. The photon generator may be operated in a spontaneous mode below a lasing threshold to emit photons. Photons emitted from the photon generator may have at least one random characteristic, which may be monitored by the QRNG to generate a random number. In one embodiment, the photon generator may include a photon emitter and an amplifier coupled to the photon emitter. The amplifier may enable the photon generator to be used in the QRNG without introducing significant bias in the random number and may enable multiplexing of multiple random numbers. The amplifier may also desensitize the photon generator to fluctuations in power supplied thereto while operating in the spontaneous mode. In one embodiment, the photon emitter and amplifier may be a tapered diode amplifier.
Solar Indices - Sunspot Numbers
National Oceanic and Atmospheric Administration, Department of Commerce — Collection includes a variety of indices related to solar activity contributed by a number of national and private solar observatories located worldwide. This...
Schwartz, Richard Evan
2014-01-01
In the American Mathematical Society's first-ever book for kids (and kids at heart), mathematician and author Richard Evan Schwartz leads math lovers of all ages on an innovative and strikingly illustrated journey through the infinite number system. By means of engaging, imaginative visuals and endearing narration, Schwartz manages the monumental task of presenting the complex concept of Big Numbers in fresh and relatable ways. The book begins with small, easily observable numbers before building up to truly gigantic ones, like a nonillion, a tredecillion, a googol, and even ones too huge for names! Any person, regardless of age, can benefit from reading this book. Readers will find themselves returning to its pages for a very long time, perpetually learning from and growing with the narrative as their knowledge deepens. Really Big Numbers is a wonderful enrichment for any math education program and is enthusiastically recommended to every teacher, parent and grandparent, student, child, or other individual i...
One could endlessly churn out congruent numbers following the method in Box 1 without being certain when a given number n (or n x m 2, for some integer m) will ap- pear on the list. Continuing in this way ·would exhaust one's computing resources, not to mention one's patience! Also, this procedure is of no avail if n is not ...
Korsby, Trine Mygind
2017-01-01
Taking a point of departure in negotiations for access to a phone number for a brothel abroad, the article demonstrates how a group of pimps in Eastern Romania attempt to extend their local business into the rest of the EU. The article shows how the phone number works as a micro-infrastructure in......Taking a point of departure in negotiations for access to a phone number for a brothel abroad, the article demonstrates how a group of pimps in Eastern Romania attempt to extend their local business into the rest of the EU. The article shows how the phone number works as a micro...... in turn cultivate and maximize uncertainty about themselves in others. When making the move to go abroad into unknown terrains, accessing the infrastructure generated by the phone number can provide certainty and consolidate one’s position within criminal networks abroad. However, at the same time......, mishandling the phone number can be dangerous and in that sense produce new doubts and uncertainties....
Mccain, W. E.
1984-01-01
The unsteady aerodynamic lifting surface theory, the Doublet Lattice method, with experimental steady and unsteady pressure measurements of a high aspect ratio supercritical wing model at a Mach number of 0.78 were compared. The steady pressure data comparisons were made for incremental changes in angle of attack and control surface deflection. The unsteady pressure data comparisons were made at set angle of attack positions with oscillating control surface deflections. Significant viscous and transonic effects in the experimental aerodynamics which cannot be predicted by the Doublet Lattice method are shown. This study should assist development of empirical correction methods that may be applied to improve Doublet Lattice calculations of lifting surface aerodynamics.
The MIXMAX random number generator
Savvidy, Konstantin G.
2015-11-01
In this paper, we study the randomness properties of unimodular matrix random number generators. Under well-known conditions, these discrete-time dynamical systems have the highly desirable K-mixing properties which guarantee high quality random numbers. It is found that some widely used random number generators have poor Kolmogorov entropy and consequently fail in empirical tests of randomness. These tests show that the lowest acceptable value of the Kolmogorov entropy is around 50. Next, we provide a solution to the problem of determining the maximal period of unimodular matrix generators of pseudo-random numbers. We formulate the necessary and sufficient condition to attain the maximum period and present a family of specific generators in the MIXMAX family with superior performance and excellent statistical properties. Finally, we construct three efficient algorithms for operations with the MIXMAX matrix which is a multi-dimensional generalization of the famous cat-map. First, allowing to compute the multiplication by the MIXMAX matrix with O(N) operations. Second, to recursively compute its characteristic polynomial with O(N2) operations, and third, to apply skips of large number of steps S to the sequence in O(N2 log(S)) operations.
Nelson, R.N. (ed.)
1985-05-01
This publication lists all report number codes processed by the Office of Scientific and Technical Information. The report codes are substantially based on the American National Standards Institute, Standard Technical Report Number (STRN)-Format and Creation Z39.23-1983. The Standard Technical Report Number (STRN) provides one of the primary methods of identifying a specific technical report. The STRN consists of two parts: The report code and the sequential number. The report code identifies the issuing organization, a specific program, or a type of document. The sequential number, which is assigned in sequence by each report issuing entity, is not included in this publication. Part I of this compilation is alphabetized by report codes followed by issuing installations. Part II lists the issuing organization followed by the assigned report code(s). In both Parts I and II, the names of issuing organizations appear for the most part in the form used at the time the reports were issued. However, for some of the more prolific installations which have had name changes, all entries have been merged under the current name.
Nelson, R.N.
1985-05-01
This publication lists all report number codes processed by the Office of Scientific and Technical Information. The report codes are substantially based on the American National Standards Institute, Standard Technical Report Number (STRN)-Format and Creation Z39.23-1983. The Standard Technical Report Number (STRN) provides one of the primary methods of identifying a specific technical report. The STRN consists of two parts: The report code and the sequential number. The report code identifies the issuing organization, a specific program, or a type of document. The sequential number, which is assigned in sequence by each report issuing entity, is not included in this publication. Part I of this compilation is alphabetized by report codes followed by issuing installations. Part II lists the issuing organization followed by the assigned report code(s). In both Parts I and II, the names of issuing organizations appear for the most part in the form used at the time the reports were issued. However, for some of the more prolific installations which have had name changes, all entries have been merged under the current name
Generation of photon number states
Waks, Edo; Diamanti, Eleni; Yamamoto, Yoshihisa
2006-01-01
The visible light photon counter (VLPC) has the capability to discriminate photon number states, in contrast to conventional photon counters which can only detect the presence or absence of photons. We use this capability, along with the process of parametric down-conversion, to generate photon number states. We experimentally demonstrate generation of states containing 1, 2, 3 and 4 photons with high fidelity. We then explore the effect the detection efficiency of the VLPC has on the generation rate and fidelity of the created states
Levin, Bruce R; McCall, Ingrid C.; Perrot, Veronique
2017-01-01
We postulate that the inhibition of growth and low rates of mortality of bacteria exposed to ribosome-binding antibiotics deemed bacteriostatic can be attributed almost uniquely to these drugs reducing the number of ribosomes contributing to protein synthesis, i.e., the number of effective......-targeting bacteriostatic antibiotics, the time before these bacteria start to grow again when the drugs are removed, referred to as the post-antibiotic effect (PAE), is markedly greater for constructs with fewer rrn operons than for those with more rrn operons. We interpret the results of these other experiments reported...... here as support for the hypothesis that the reduction in the effective number of ribosomes due to binding to these structures provides a sufficient explanation for the action of bacteriostatic antibiotics that target these structures....
Alizée Dauvergne
2010-01-01
What makes the LHC the biggest particle accelerator in the world? Here are some of the numbers that characterise the LHC, and their equivalents in terms that are easier for us to imagine. Feature Number Equivalent Circumference ~ 27 km Distance covered by beam in 10 hours ~ 10 billion km a round trip to Neptune Number of times a single proton travels around the ring each second 11 245 Speed of protons first entering the LHC 299 732 500 m/s 99.9998 % of the speed of light Speed of protons when they collide 299 789 760 m/s 99.9999991 % of the speed of light Collision temperature ~ 1016 °C ove...
Khera, Amit V; Demler, Olga V; Adelman, Steven J; Collins, Heidi L; Glynn, Robert J; Ridker, Paul M; Rader, Daniel J; Mora, Samia
2017-06-20
Recent failures of drugs that raised high-density lipoprotein (HDL) cholesterol levels to reduce cardiovascular events in clinical trials have led to increased interest in alternative indices of HDL quality, such as cholesterol efflux capacity, and HDL quantity, such as HDL particle number. However, no studies have directly compared these metrics in a contemporary population that includes potent statin therapy and low low-density lipoprotein cholesterol. HDL cholesterol levels, apolipoprotein A-I, cholesterol efflux capacity, and HDL particle number were assessed at baseline and 12 months in a nested case-control study of the JUPITER trial (Justification for the Use of Statins in Prevention: An Intervention Trial Evaluating Rosuvastatin), a randomized primary prevention trial that compared rosuvastatin treatment to placebo in individuals with normal low-density lipoprotein cholesterol but increased C-reactive protein levels. In total, 314 cases of incident cardiovascular disease (CVD) (myocardial infarction, unstable angina, arterial revascularization, stroke, or cardiovascular death) were compared to age- and gender-matched controls. Conditional logistic regression models adjusting for risk factors evaluated associations between HDL-related biomarkers and incident CVD. Cholesterol efflux capacity was moderately correlated with HDL cholesterol, apolipoprotein A-I, and HDL particle number (Spearman r = 0.39, 0.48, and 0.39 respectively; P capacity (OR/SD, 0.89; 95% CI, 0.72-1.10; P =0.28), HDL cholesterol (OR/SD, 0.82; 95% CI, 0.66-1.02; P =0.08), or apolipoprotein A-I (OR/SD, 0.83; 95% CI, 0.67-1.03; P =0.08). Twelve months of rosuvastatin (20 mg/day) did not change cholesterol efflux capacity (average percentage change -1.5%, 95% CI, -13.3 to +10.2; P =0.80), but increased HDL cholesterol (+7.7%), apolipoprotein A-I (+4.3%), and HDL particle number (+5.2%). On-statin cholesterol efflux capacity was inversely associated with incident CVD (OR/SD, 0.62; 95% CI, 0
Samuel, Pierre
2008-01-01
Algebraic number theory introduces students not only to new algebraic notions but also to related concepts: groups, rings, fields, ideals, quotient rings and quotient fields, homomorphisms and isomorphisms, modules, and vector spaces. Author Pierre Samuel notes that students benefit from their studies of algebraic number theory by encountering many concepts fundamental to other branches of mathematics - algebraic geometry, in particular.This book assumes a knowledge of basic algebra but supplements its teachings with brief, clear explanations of integrality, algebraic extensions of fields, Gal
Iwaniec, Henryk
2004-01-01
Analytic Number Theory distinguishes itself by the variety of tools it uses to establish results, many of which belong to the mainstream of arithmetic. One of the main attractions of analytic number theory is the vast diversity of concepts and methods it includes. The main goal of the book is to show the scope of the theory, both in classical and modern directions, and to exhibit its wealth and prospects, its beautiful theorems and powerful techniques. The book is written with graduate students in mind, and the authors tried to balance between clarity, completeness, and generality. The exercis