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Sample records for high correlation pearson

  1. Alternatives to Pearson's and Spearman's Correlation Coefficients

    OpenAIRE

    Smarandache, Florentin

    2008-01-01

    This article presents several alternatives to Pearson's correlation coefficient and many examples. In the samples where the rank in a discrete variable counts more than the variable values, the mixtures that we propose of Pearson's and Spearman's correlation coefficients give better results.

  2. Correlation Structure of Fractional Pearson Diffusions.

    Science.gov (United States)

    Leonenko, Nikolai N; Meerschaert, Mark M; Sikorskii, Alla

    2013-09-01

    The stochastic solution to a diffusion equations with polynomial coefficients is called a Pearson diffusion. If the first time derivative is replaced by a Caputo fractional derivative of order less than one, the stochastic solution is called a fractional Pearson diffusion. This paper develops an explicit formula for the covariance function of a fractional Pearson diffusion in steady state, in terms of Mittag-Leffler functions. That formula shows that fractional Pearson diffusions are long range dependent, with a correlation that falls off like a power law, whose exponent equals the order of the fractional derivative.

  3. The Evolution of Pearson's Correlation Coefficient

    Science.gov (United States)

    Kader, Gary D.; Franklin, Christine A.

    2008-01-01

    This article describes an activity for developing the notion of association between two quantitative variables. By exploring a collection of scatter plots, the authors propose a nonstandard "intuitive" measure of association; and by examining properties of this measure, they develop the more standard measure, Pearson's Correlation Coefficient. The…

  4. The Evolution of Pearson's Correlation Coefficient

    Science.gov (United States)

    Kader, Gary D.; Franklin, Christine A.

    2008-01-01

    This article describes an activity for developing the notion of association between two quantitative variables. By exploring a collection of scatter plots, the authors propose a nonstandard "intuitive" measure of association; and by examining properties of this measure, they develop the more standard measure, Pearson's Correlation Coefficient. The…

  5. Improvement of Similarity Measure: Pearson Product-Moment Correlation Coefficient

    Institute of Scientific and Technical Information of China (English)

    LIUYong-suo; MENGQing-hua; CHENRong; WANGJian-song; JIANGShu-min; HUYu-zhu

    2004-01-01

    Aim To study the reason of the insensitiveness of Pearson preduct-moment correlation coefficient as a similarity measure and the method to improve its sensitivity. Methods Experimental and simulated data sets were used. Results The distribution range of the data sets influences the sensitivity of Pearson product-moment correlation coefficient. Weighted Pearson product-moment correlation coefficient is more sensitive when the range of the data set is large. Conclusion Weighted Pearson product-moment correlation coefficient is necessary when the range of the data set is large.

  6. Sample Size Requirements for Estimating Pearson, Spearman and Kendall Correlations.

    Science.gov (United States)

    Bonett, Douglas G.; Wright, Thomas A.

    2000-01-01

    Reviews interval estimates of the Pearson, Kendall tau-alpha, and Spearman correlates and proposes an improved standard error for the Spearman correlation. Examines the sample size required to yield a confidence interval having the desired width. Findings show accurate results from a two-stage approximation to the sample size. (SLD)

  7. On Clustering Time Series Using Euclidean Distance and Pearson Correlation

    OpenAIRE

    Berthold, Michael R.; Höppner, Frank

    2016-01-01

    For time series comparisons, it has often been observed that z-score normalized Euclidean distances far outperform the unnormalized variant. In this paper we show that a z-score normalized, squared Euclidean Distance is, in fact, equal to a distance based on Pearson Correlation. This has profound impact on many distance-based classification or clustering methods. In addition to this theoretically sound result we also show that the often used k-Means algorithm formally needs a mod ification to...

  8. Correlation structure of time-changed Pearson diffusions

    OpenAIRE

    Mijena, Jebessa B.; Nane, Erkan

    2014-01-01

    The stochastic solution to diffusion equations with polynomial coefficients is called a Pearson diffusion. If the time derivative is replaced by a distributed fractional derivative, the stochastic solution is called a fractional Pearson diffusion. This paper develops a formula for the covariance function of a fractional Pearson diffusion in steady state, in terms of generalized Mittag-Leffler functions. That formula shows that fractional Pearson diffusions are long-range dependent, with a cor...

  9. A new method to evaluate the similarity of chromatographic fingerprints: weighted pearson product-moment correlation coefficient.

    Science.gov (United States)

    Liu, Yongsuo; Meng, Qinghua; Chen, Rong; Wang, Jiansong; Jiang, Shumin; Hu, Yuzhu

    2004-01-01

    The Pearson product-moment correlation coefficient is being used to evaluate the similarity of the high-performance liquid chromatographic fingerprints of traditional Chinese medicine (TCM) in China. It is confirmed that a large range of peak areas produced the wrong results. A new algorithm concerning weighted Pearson product-moment correlation coefficient is proposed in this article. The results for both real cases and simulated data sets show that the weighted Pearson product-moment correlation coefficients allow relatively larger differences for large values, smaller differences for small values, and more reliable results than the unweighted Pearson product-moment correlation coefficients. Weight selection depends on the specific scientific problem.

  10. Quantifying colocalization by correlation: the Pearson correlation coefficient is superior to the Mander's overlap coefficient.

    Science.gov (United States)

    Adler, Jeremy; Parmryd, Ingela

    2010-08-01

    The Pearson correlation coefficient (PCC) and the Mander's overlap coefficient (MOC) are used to quantify the degree of colocalization between fluorophores. The MOC was introduced to overcome perceived problems with the PCC. The two coefficients are mathematically similar, differing in the use of either the absolute intensities (MOC) or of the deviation from the mean (PCC). A range of correlated datasets, which extend to the limits of the PCC, only evoked a limited response from the MOC. The PCC is unaffected by changes to the offset while the MOC increases when the offset is positive. Both coefficients are independent of gain. The MOC is a confusing hybrid measurement, that combines correlation with a heavily weighted form of co-occurrence, favors high intensity combinations, downplays combinations in which either or both intensities are low and ignores blank pixels. The PCC only measures correlation. A surprising finding was that the addition of a second uncorrelated population can substantially increase the measured correlation, demonstrating the importance of excluding background pixels. Overall, since the MOC is unresponsive to substantial changes in the data and is hard to interpret, it is neither an alternative to nor a useful substitute for the PCC. The MOC is not suitable for making measurements of colocalization either by correlation or co-occurrence.

  11. Correlation Revelation: The Search for Meaning in Pearson's Coefficient

    Science.gov (United States)

    Huhn, Craig

    2016-01-01

    When the author was first charged with getting a group of students to understand the correlation coefficient, he did not anticipate the topic would challenge his own understanding, let alone cause him to eventually question the very nature of mathematics itself. On the surface, the idea seemed straightforward, one that millions of students across…

  12. Enhancement of hidden structures of early skin fibrosis using polarization degree patterns and Pearson correlation analysis.

    Science.gov (United States)

    Sviridov, Alexander P; Chernomordik, Victor; Hassan, Moinuddin; Boccara, Albert C; Russo, Angelo; Smith, Paul; Gandjbakhche, Amir

    2005-01-01

    The skin of athymic nude mice is irradiated with a single dose of x-ray irradiation that initiated fibrosis. Digital photographs of the irradiated mice are taken by illuminating the mouse skin with linearly polarized probe light of 650 nm. The specific pattern of the surface distribution of the degree of polarization enables the detection of initial skin fibrosis structures that were not visually apparent. Data processing of the raw spatial distributions of the degree of polarization based on Fourier filtering of the high-frequency noise improves subjective perception of the revealed structure in the images. In addition, Pearson correlation analysis provides information about skin structural size and directionality.

  13. Robustness of Two Formulas to Correct Pearson Correlation for Restriction of Range

    Science.gov (United States)

    tran, minh

    2011-01-01

    Many research studies involving Pearson correlations are conducted in settings where one of the two variables has a restricted range in the sample. For example, this situation occurs when tests are used for selecting candidates for employment or university admission. Often after selection, there is interest in correlating the selection variable,…

  14. On the graph-theoretical interpretation of Pearson correlations in a multivariate process and a novel partial correlation measure

    OpenAIRE

    Runge, Jakob

    2013-01-01

    The dependencies of the lagged (Pearson) correlation function on the coefficients of multivariate autoregressive models are interpreted in the framework of time series graphs. Time series graphs are related to the concept of Granger causality and encode the conditional independence structure of a multivariate process. The authors show that the complex dependencies of the Pearson correlation coefficient complicate an interpretation and propose a novel partial correlation measure with a straigh...

  15. Correlation Between Posttraumatic Growth and Posttraumatic Stress Disorder Symptoms Based on Pearson Correlation Coefficient: A Meta-Analysis.

    Science.gov (United States)

    Liu, An-Nuo; Wang, Lu-Lu; Li, Hui-Ping; Gong, Juan; Liu, Xiao-Hong

    2016-11-22

    The literature on posttraumatic growth (PTG) is burgeoning, with the inconsistencies in the literature of the relationship between PTG and posttraumatic stress disorder (PTSD) symptoms becoming a focal point of attention. Thus, this meta-analysis aims to explore the relationship between PTG and PTSD symptoms through the Pearson correlation coefficient. A systematic search of the literature from January 1996 to November 2015 was completed. We retrieved reports on 63 studies that involved 26,951 patients. The weighted correlation coefficient revealed an effect size of 0.22 with a 95% confidence interval of 0.18 to 0.25. Meta-analysis provides evidence that PTG may be positively correlated with PTSD symptoms and that this correlation may be modified by age, trauma type, and time since trauma. Accordingly, people with high levels of PTG should not be ignored, but rather, they should continue to receive help to alleviate their PTSD symptoms.

  16. Some Properties of the Pearson Correlation Matrix of Guttman-Scalable Items.

    Science.gov (United States)

    Zwick, Rebecca

    Although perfectly scalable items rarely occur in practice, Guttman's concept of a scale has proved to be valuable to the development of measurement theory. If the score distribution is uniform and there is an equal number of items at each difficulty level, both the elements and the eigenvalues of the Pearson correlation matrix of dichotomous…

  17. Colocalization analysis in fluorescence micrographs: verification of a more accurate calculation of pearson's correlation coefficient.

    Science.gov (United States)

    Barlow, Andrew L; Macleod, Alasdair; Noppen, Samuel; Sanderson, Jeremy; Guérin, Christopher J

    2010-12-01

    One of the most routine uses of fluorescence microscopy is colocalization, i.e., the demonstration of a relationship between pairs of biological molecules. Frequently this is presented simplistically by the use of overlays of red and green images, with areas of yellow indicating colocalization of the molecules. Colocalization data are rarely quantified and can be misleading. Our results from both synthetic and biological datasets demonstrate that the generation of Pearson's correlation coefficient between pairs of images can overestimate positive correlation and fail to demonstrate negative correlation. We have demonstrated that the calculation of a thresholded Pearson's correlation coefficient using only intensity values over a determined threshold in both channels produces numerical values that more accurately describe both synthetic datasets and biological examples. Its use will bring clarity and accuracy to colocalization studies using fluorescent microscopy.

  18. Variation and Pearson correlation coefficients of Warner-Bratzler shear force measurements within broiler breast fillets.

    Science.gov (United States)

    Zhuang, H; Savage, E M

    2009-01-01

    Measurements of texture properties related to tenderness at different locations within deboned broiler breast fillets have been used to validate techniques for texture analysis and establish correlations between different texture evaluation methods. However, it has been demonstrated that meat texture can vary from location to location within individual muscles. The objective of our study was to investigate the intramuscular variation and Pearson correlation coefficients of Warner-Bratzler (WB) shear force measurements within early deboned broiler breast fillets and the effect of deboning time and cold storage on the variation and correlation coefficients. Broiler breast fillets were removed from carcasses early postmortem (2 h) and later postmortem (24 h). Storage treatments of the 2 h samples included 0 d, 7 d at 3 degrees C, 7 d at -20 degrees C, and 6 d at -20 degrees C plus 1 d at 3 degrees C. The WB shears of cooked fillets were measured using a TA-XTPlus Texture Analyzer and a TA-7 WB shear type blade. Our results showed that although the average WB shear force values differed within the 0-d, 2-h fillets, compared with the variation among the fillets within the treatment, the difference within a fillet is still evidently small. The Pearson correlation coefficients were significant between the locations; however, values of the correlation coefficients depended on the paired locations. Location differences in the WB shear values and the correlation coefficient values between them changed with deboning time and cold storage. These results demonstrate that the variation of WB shear force measurements is substantial within early deboned broiler breast fillets and the Pearson correlation coefficient values of the measurements vary among the locations. Both the variation and the Pearson correlation coefficients can be affected by postmortem aging time and storage. The differences in the means between the locations in early deboned breasts are much smaller than the

  19. MIrExpress: A Database for Gene Coexpression Correlation in Immune Cells Based on Mutual Information and Pearson Correlation

    OpenAIRE

    Luman Wang; Qiaochu Mo; Jianxin Wang

    2015-01-01

    Most current gene coexpression databases support the analysis for linear correlation of gene pairs, but not nonlinear correlation of them, which hinders precisely evaluating the gene-gene coexpression strengths. Here, we report a new database, MIrExpress, which takes advantage of the information theory, as well as the Pearson linear correlation method, to measure the linear correlation, nonlinear correlation, and their hybrid of cell-specific gene coexpressions in immune cells. For a given ge...

  20. A novel fractal image compression scheme with block classification and sorting based on Pearson's correlation coefficient.

    Science.gov (United States)

    Wang, Jianji; Zheng, Nanning

    2013-09-01

    Fractal image compression (FIC) is an image coding technology based on the local similarity of image structure. It is widely used in many fields such as image retrieval, image denoising, image authentication, and encryption. FIC, however, suffers from the high computational complexity in encoding. Although many schemes are published to speed up encoding, they do not easily satisfy the encoding time or the reconstructed image quality requirements. In this paper, a new FIC scheme is proposed based on the fact that the affine similarity between two blocks in FIC is equivalent to the absolute value of Pearson's correlation coefficient (APCC) between them. First, all blocks in the range and domain pools are chosen and classified using an APCC-based block classification method to increase the matching probability. Second, by sorting the domain blocks with respect to APCCs between these domain blocks and a preset block in each class, the matching domain block for a range block can be searched in the selected domain set in which these APCCs are closer to APCC between the range block and the preset block. Experimental results show that the proposed scheme can significantly speed up the encoding process in FIC while preserving the reconstructed image quality well.

  1. Gender and Age Analyses of NIRS/STAI Pearson Correlation Coefficients at Resting State.

    Science.gov (United States)

    Matsumoto, T; Fuchita, Y; Ichikawa, K; Fukuda, Y; Takemura, N; Sakatani, K

    2016-01-01

    According to the valence asymmetry hypothesis, the left/right asymmetry of PFC activity is correlated with specific emotional responses to mental stress and personality traits. In a previous study we measured spontaneous oscillation of oxy-Hb concentrations in the bilateral PFC at rest in normal adults employing two-channel portable NIRS and computed the laterality index at rest (LIR). We investigated the Pearson correlation coefficient between the LIR and anxiety levels evaluated by the State-Trait Anxiety Inventory (STAI) test. We found that subjects with right-dominant activity at rest showed higher STAI scores, while those with left dominant oxy-Hb changes at rest showed lower STAI scores such that the Pearson correlation coefficient between LIR and STAI was positive. This study performed Bootstrap analysis on the data and showed the following statistics of the target correlation coefficient: mean=0.4925 and lower confidence limit=0.177 with confidence level 0.05. Using the KS-test, we demonstrated that the correlation did not depend on age, whereas it did depend on gender.

  2. A new method for improving functional-to-structural MRI alignment using local Pearson correlation.

    Science.gov (United States)

    Saad, Ziad S; Glen, Daniel R; Chen, Gang; Beauchamp, Michael S; Desai, Rutvik; Cox, Robert W

    2009-02-01

    Accurate registration of Functional Magnetic Resonance Imaging (FMRI) T2-weighted volumes to same-subject high-resolution T1-weighted structural volumes is important for Blood Oxygenation Level Dependent (BOLD) FMRI and crucial for applications such as cortical surface-based analyses and pre-surgical planning. Such registration is generally implemented by minimizing a cost functional, which measures the mismatch between two image volumes over the group of proper affine transformations. Widely used cost functionals, such as mutual information (MI) and correlation ratio (CR), appear to yield decent alignments when visually judged by matching outer brain contours. However, close inspection reveals that internal brain structures are often significantly misaligned. Poor registration is most evident in the ventricles and sulcal folds, where CSF is concentrated. This observation motivated our development of an improved modality-specific cost functional which uses a weighted local Pearson coefficient (LPC) to align T2- and T1-weighted images. In the absence of an alignment gold standard, we used three human observers blinded to registration method to provide an independent assessment of the quality of the registration for each cost functional. We found that LPC performed significantly better (p<0.001) than generic cost functionals including MI and CR. Generic cost functionals were very often not minimal near the best alignment, thereby suggesting that optimization is not the cause of their failure. Lastly, we emphasize the importance of precise visual inspection of alignment quality and present an automated method for generating composite images that help capture errors of misalignment.

  3. Asymptotic properties of Pearson's rank-variate correlation coefficient under contaminated Gaussian model.

    Science.gov (United States)

    Ma, Rubao; Xu, Weichao; Zhang, Yun; Ye, Zhongfu

    2014-01-01

    This paper investigates the robustness properties of Pearson's rank-variate correlation coefficient (PRVCC) in scenarios where one channel is corrupted by impulsive noise and the other is impulsive noise-free. As shown in our previous work, these scenarios that frequently encountered in radar and/or sonar, can be well emulated by a particular bivariate contaminated Gaussian model (CGM). Under this CGM, we establish the asymptotic closed forms of the expectation and variance of PRVCC by means of the well known Delta method. To gain a deeper understanding, we also compare PRVCC with two other classical correlation coefficients, i.e., Spearman's rho (SR) and Kendall's tau (KT), in terms of the root mean squared error (RMSE). Monte Carlo simulations not only verify our theoretical findings, but also reveal the advantage of PRVCC by an example of estimating the time delay in the particular impulsive noise environment.

  4. MIrExpress: A Database for Gene Coexpression Correlation in Immune Cells Based on Mutual Information and Pearson Correlation.

    Science.gov (United States)

    Wang, Luman; Mo, Qiaochu; Wang, Jianxin

    2015-01-01

    Most current gene coexpression databases support the analysis for linear correlation of gene pairs, but not nonlinear correlation of them, which hinders precisely evaluating the gene-gene coexpression strengths. Here, we report a new database, MIrExpress, which takes advantage of the information theory, as well as the Pearson linear correlation method, to measure the linear correlation, nonlinear correlation, and their hybrid of cell-specific gene coexpressions in immune cells. For a given gene pair or probe set pair input by web users, both mutual information (MI) and Pearson correlation coefficient (r) are calculated, and several corresponding values are reported to reflect their coexpression correlation nature, including MI and r values, their respective rank orderings, their rank comparison, and their hybrid correlation value. Furthermore, for a given gene, the top 10 most relevant genes to it are displayed with the MI, r, or their hybrid perspective, respectively. Currently, the database totally includes 16 human cell groups, involving 20,283 human genes. The expression data and the calculated correlation results from the database are interactively accessible on the web page and can be implemented for other related applications and researches.

  5. SPSS and SAS programs for comparing Pearson correlations and OLS regression coefficients.

    Science.gov (United States)

    Weaver, Bruce; Wuensch, Karl L

    2013-09-01

    Several procedures that use summary data to test hypotheses about Pearson correlations and ordinary least squares regression coefficients have been described in various books and articles. To our knowledge, however, no single resource describes all of the most common tests. Furthermore, many of these tests have not yet been implemented in popular statistical software packages such as SPSS and SAS. In this article, we describe all of the most common tests and provide SPSS and SAS programs to perform them. When they are applicable, our code also computes 100 × (1 - α)% confidence intervals corresponding to the tests. For testing hypotheses about independent regression coefficients, we demonstrate one method that uses summary data and another that uses raw data (i.e., Potthoff analysis). When the raw data are available, the latter method is preferred, because use of summary data entails some loss of precision due to rounding.

  6. Dependency Test: Portraying Pearson's Correlation Coefficient Targeting Activities in Project Scheduling

    Directory of Open Access Journals (Sweden)

    Jana Shafi

    2016-09-01

    Full Text Available In this paper, we discuss project scheduling with conflicting activity-resources. Several project activities require same resources but, may be scheduled with the certain lapse of time resulting in repeatedly using the same kind of resources for executing dissimilar activities. Due to the frequent usage of same resources multiple times, expenditure become more expensive and project duration extends. The problem is to find out such kind of activities which are developing implicit relations amid them. , we proposed a solution by introducing TVs (Transparent view of Scheduling model. First, we analyze and enlists activities according to required resources, categorize them and then we segregate dependent and independent activities by indicating a value. Performing Dependency test on activities by using Pearson's Correlation Coefficient (PCC to calculate the rate of relations among the ordered activities for similar resources. By using this model we can reschedule activities to avoid confusion and disordering of resources without consumption of time and capital.

  7. Testing the significance of a correlation with nonnormal data: comparison of Pearson, Spearman, transformation, and resampling approaches.

    Science.gov (United States)

    Bishara, Anthony J; Hittner, James B

    2012-09-01

    It is well known that when data are nonnormally distributed, a test of the significance of Pearson's r may inflate Type I error rates and reduce power. Statistics textbooks and the simulation literature provide several alternatives to Pearson's correlation. However, the relative performance of these alternatives has been unclear. Two simulation studies were conducted to compare 12 methods, including Pearson, Spearman's rank-order, transformation, and resampling approaches. With most sample sizes (n ≥ 20), Type I and Type II error rates were minimized by transforming the data to a normal shape prior to assessing the Pearson correlation. Among transformation approaches, a general purpose rank-based inverse normal transformation (i.e., transformation to rankit scores) was most beneficial. However, when samples were both small (n ≤ 10) and extremely nonnormal, the permutation test often outperformed other alternatives, including various bootstrap tests.

  8. Pearson's Correlation between Three Variables; Using Students' Basic Knowledge of Geometry for an Exercise in Mathematical Statistics

    Science.gov (United States)

    Vos, Pauline

    2009-01-01

    When studying correlations, how do the three bivariate correlation coefficients between three variables relate? After transforming Pearson's correlation coefficient r into a Euclidean distance, undergraduate students can tackle this problem using their secondary school knowledge of geometry (Pythagoras' theorem and similarity of triangles).…

  9. Comparing the Pearson and Spearman correlation coefficients across distributions and sample sizes: A tutorial using simulations and empirical data.

    Science.gov (United States)

    de Winter, Joost C F; Gosling, Samuel D; Potter, Jeff

    2016-09-01

    The Pearson product–moment correlation coefficient (rp) and the Spearman rank correlation coefficient (rs) are widely used in psychological research. We compare rp and rs on 3 criteria: variability, bias with respect to the population value, and robustness to an outlier. Using simulations across low (N = 5) to high (N = 1,000) sample sizes we show that, for normally distributed variables, rp and rs have similar expected values but rs is more variable, especially when the correlation is strong. However, when the variables have high kurtosis, rp is more variable than rs. Next, we conducted a sampling study of a psychometric dataset featuring symmetrically distributed data with light tails, and of 2 Likert-type survey datasets, 1 with light-tailed and the other with heavy-tailed distributions. Consistent with the simulations, rp had lower variability than rs in the psychometric dataset. In the survey datasets with heavy-tailed variables in particular, rs had lower variability than rp, and often corresponded more accurately to the population Pearson correlation coefficient (Rp) than rp did. The simulations and the sampling studies showed that variability in terms of standard deviations can be reduced by about 20% by choosing rs instead of rp. In comparison, increasing the sample size by a factor of 2 results in a 41% reduction of the standard deviations of rs and rp. In conclusion, rp is suitable for light-tailed distributions, whereas rs is preferable when variables feature heavy-tailed distributions or when outliers are present, as is often the case in psychological research.

  10. Remodeling Pearson's Correlation for Functional Brain Network Estimation and Autism Spectrum Disorder Identification

    Directory of Open Access Journals (Sweden)

    Weikai Li

    2017-08-01

    Full Text Available Functional brain network (FBN has been becoming an increasingly important way to model the statistical dependence among neural time courses of brain, and provides effective imaging biomarkers for diagnosis of some neurological or psychological disorders. Currently, Pearson's Correlation (PC is the simplest and most widely-used method in constructing FBNs. Despite its advantages in statistical meaning and calculated performance, the PC tends to result in a FBN with dense connections. Therefore, in practice, the PC-based FBN needs to be sparsified by removing weak (potential noisy connections. However, such a scheme depends on a hard-threshold without enough flexibility. Different from this traditional strategy, in this paper, we propose a new approach for estimating FBNs by remodeling PC as an optimization problem, which provides a way to incorporate biological/physical priors into the FBNs. In particular, we introduce an L1-norm regularizer into the optimization model for obtaining a sparse solution. Compared with the hard-threshold scheme, the proposed framework gives an elegant mathematical formulation for sparsifying PC-based networks. More importantly, it provides a platform to encode other biological/physical priors into the PC-based FBNs. To further illustrate the flexibility of the proposed method, we extend the model to a weighted counterpart for learning both sparse and scale-free networks, and then conduct experiments to identify autism spectrum disorders (ASD from normal controls (NC based on the constructed FBNs. Consequently, we achieved an 81.52% classification accuracy which outperforms the baseline and state-of-the-art methods.

  11. On the Relationship between Pearson Correlation Coefficient and Kendall’s Tau under Bivariate Homogeneous Shock Model

    OpenAIRE

    Jiantian Wang

    2012-01-01

    This paper studies the relationship between Kendall's tau and Pearson correlation coefficient under the so-called bivariate homogeneous shock (BHS) model. We find Capéraà-Genest-type inequality may not hold for general BHS model. Computational simulations suggest that the Denials' inequality is likely to be true.

  12. Use of semiselective TOCSY and the pearson correlation for the metabonomic analysis of biofluid mixtures: application to urine.

    Science.gov (United States)

    Sandusky, Peter; Raftery, Daniel

    2005-12-01

    The authors recently proposed an approach to the metabonomic analysis of biofluid mixtures based on the use of the selective TOCSY experiment (Sandusky, P.; Raftery, D. Anal. Chem. 2005, 77, 2455). This method has some significant advantages over standard metabonomic analysis. However, when analyzing overlapped components, the selective TOCSY method can suffer from the relatively high likelihood of simultaneous excitation of several spin systems at once. This multiple excitation can cause problems both with the purity of the individual TOCSY peaks observed and with their assignment into specific spin systems. To address this problem, the possibility of using a more selective excitation is initially explored. Unfortunately, in most cases, greater spin system selectivity can only be gained at the expense of sensitivity. This is obviously an unacceptable tradeoff when dealing with biofluid samples. However, the application of the Pearson product moment correlation to the TOCSY peak integral intensities provides a test for individual TOCSY peak purity and allows for the assignment of the peaks into spin systems. The specific application of this two-stage "semiselective" TOCSY method to rat and human urine is presented. Significantly, it is also demonstrated that the use of semiselective TOCSY spectra as data inputs for PCA calculations provides a more sensitive and reliable method of distinguishing small differences in biofluid composition than the standard metabonomic approach using complete 1D proton NMR spectra of urine samples.

  13. Reconstructing gene regulatory networks from knock-out data using Gaussian Noise Model and Pearson Correlation Coefficient.

    Science.gov (United States)

    Mohamed Salleh, Faridah Hani; Arif, Shereena Mohd; Zainudin, Suhaila; Firdaus-Raih, Mohd

    2015-12-01

    A gene regulatory network (GRN) is a large and complex network consisting of interacting elements that, over time, affect each other's state. The dynamics of complex gene regulatory processes are difficult to understand using intuitive approaches alone. To overcome this problem, we propose an algorithm for inferring the regulatory interactions from knock-out data using a Gaussian model combines with Pearson Correlation Coefficient (PCC). There are several problems relating to GRN construction that have been outlined in this paper. We demonstrated the ability of our proposed method to (1) predict the presence of regulatory interactions between genes, (2) their directionality and (3) their states (activation or suppression). The algorithm was applied to network sizes of 10 and 50 genes from DREAM3 datasets and network sizes of 10 from DREAM4 datasets. The predicted networks were evaluated based on AUROC and AUPR. We discovered that high false positive values were generated by our GRN prediction methods because the indirect regulations have been wrongly predicted as true relationships. We achieved satisfactory results as the majority of sub-networks achieved AUROC values above 0.5.

  14. Hapten-antibody recognition studies in competitive immunoassay of α-zearalanol analogs by computational chemistry and Pearson Correlation analysis.

    Science.gov (United States)

    Wang, Zhanhui; Luo, Pengjie; Cheng, Linli; Zhang, Suxia; Shen, Jianzhong

    2011-01-01

    The molecular recognition of hapten-antibody is a fundamental event in competitive immunoassay, which guarantees the sensitivity and specificity of immunoassay for the detection of haptens. The aim of this study is to investigate the correlation between binding ability of one monoclonal antibody, 1H9B4, recognizing and the molecular aspects of α-zearalanol analogs. The mouse-derived monoclonal antibody was produced by using α-zearalanol conjugated to bovine serum albumin as an immunogen. The antibody recognition abilities, expressed as IC(50) values, were determined by a competitive ELISA. All of the hapten molecules were optimized by Density Function Theory (DFT) at B3LYP/ 6-31G* level and the conformation and electrostatic molecular isosurface were employed to explain the molecular recognition between α-zearalanol analogs and antibody 1H9B4. Pearson Correlation analysis between molecular descriptors and IC(50) values was qualitatively undertaken and the results showed that one molecular descriptor, surface of the hapten molecule, clearly demonstrated linear relationship with antibody recognition ability, where the relationship coefficient was 0.88 and the correlation was significant at p Pearson Correlation analysis can be used as tool to help the immunochemistries better understand the processing of antibody recognition of hapten molecules in competitive immunoassay.

  15. Variation and pearson correlation coefficients of warner-bratzler shear force measurements within broiler breast fillets

    Science.gov (United States)

    Measurements of texture properties related to tenderness at different locations within deboned broiler breast fillets have been used to validate techniques for texture analysis and establish correlations between different texture evaluation methods. However, it has been demonstrated that meat text...

  16. A Non-Simulation Based Method for Inducing Pearson’s Correlation Between Input Random Variables

    Science.gov (United States)

    2008-04-23

    Thanks to Dr. Steven Book of MCR for his help in obtaining copies of several papers on correlation modules, without which this paper would not have been...risks, not estimating variation SWBS Description Upside Probable Downside 000 Administration 100 Hull 200 Propulsion 300 Electric Plant 400 Electonics ...Systems 500 Auxillary Systems 600 Outfit & Furnishings 700 Weapons 800 Integration & Engineering 900 Ship Assembly & Support Total SWBS Description

  17. Method for stationarity-segmentation of spike train data with application to the Pearson cross-correlation.

    Science.gov (United States)

    Quiroga-Lombard, Claudio S; Hass, Joachim; Durstewitz, Daniel

    2013-07-01

    Correlations among neurons are supposed to play an important role in computation and information coding in the nervous system. Empirically, functional interactions between neurons are most commonly assessed by cross-correlation functions. Recent studies have suggested that pairwise correlations may indeed be sufficient to capture most of the information present in neural interactions. Many applications of correlation functions, however, implicitly tend to assume that the underlying processes are stationary. This assumption will usually fail for real neurons recorded in vivo since their activity during behavioral tasks is heavily influenced by stimulus-, movement-, or cognition-related processes as well as by more general processes like slow oscillations or changes in state of alertness. To address the problem of nonstationarity, we introduce a method for assessing stationarity empirically and then "slicing" spike trains into stationary segments according to the statistical definition of weak-sense stationarity. We examine pairwise Pearson cross-correlations (PCCs) under both stationary and nonstationary conditions and identify another source of covariance that can be differentiated from the covariance of the spike times and emerges as a consequence of residual nonstationarities after the slicing process: the covariance of the firing rates defined on each segment. Based on this, a correction of the PCC is introduced that accounts for the effect of segmentation. We probe these methods both on simulated data sets and on in vivo recordings from the prefrontal cortex of behaving rats. Rather than for removing nonstationarities, the present method may also be used for detecting significant events in spike trains.

  18. An automated Pearson's correlation change classification (APC3) approach for GC/MS metabonomic data using total ion chromatograms (TICs).

    Science.gov (United States)

    Prakash, Bhaskaran David; Esuvaranathan, Kesavan; Ho, Paul C; Pasikanti, Kishore Kumar; Chan, Eric Chun Yong; Yap, Chun Wei

    2013-05-21

    A fully automated and computationally efficient Pearson's correlation change classification (APC3) approach is proposed and shown to have overall comparable performance with both an average accuracy and an average AUC of 0.89 ± 0.08 but is 3.9 to 7 times faster, easier to use and have low outlier susceptibility in contrast to other dimensional reduction and classification combinations using only the total ion chromatogram (TIC) intensities of GC/MS data. The use of only the TIC permits the possible application of APC3 to other metabonomic data such as LC/MS TICs or NMR spectra. A RapidMiner implementation is available for download at http://padel.nus.edu.sg/software/padelapc3.

  19. Improvement of Similarity Measure:Pearson Product-Moment Correlation Coefficient%相似度的评价指标相关系数的改进

    Institute of Scientific and Technical Information of China (English)

    刘永锁; 孟庆华; 陈蓉; 王健松; 蒋淑敏; 胡育筑

    2004-01-01

    Aim To study the reason of the insensitiveness of Pearson product-moment correlation coefficient as a similarity measure and the method to improve its sensitivity. Methods Experimental and simulated data sets were used. Results The distribution range of the data sets influences the sensitivity of Pearson product-moment correlation coefficient.Weighted Pearson product-moment correlation coefficient is more sensitive when the range of the data set is large. Conclusion Weighted Pearson product-moment correlation coefficient is necessary when the range of the data set is large.%目的研究相似度的评价指标:相关系数的灵敏度低的原因及其改进的方法.方法利用实验数据和模拟数据研究相关系数的灵敏度低的问题.结果相关系数的灵敏度受数据的分布范围的影响,在数据的分布范围宽时加权相关系数更灵敏.结论在数据的分布范围宽时有必要进行加权运算.

  20. Pearson相关系数法快慢横波波场分离%Wave filed separation of fast-slow shear waves by Pearson correlation coefficient method

    Institute of Scientific and Technical Information of China (English)

    王凯; 冯晅; 刘财

    2012-01-01

    横波分裂是各向异性介质的重要特征,当横波或转换波穿过各向异性介质到达地面时,地面三分量检波器的x分量和y分量接收到的地震记录中都会同时存在快横波和慢横波.将快横波和慢横波进行分离,进而计算介质的各向异性参数是多分量数据处理中重要的一步.将数学中的Pearson相关系数引入到多分量地震勘探中,提出了Pearson相关系数法进行旋转角度识别,进而分离快、慢横波波场.相比于传统的互相关法,Pearson相关系数法从精度、抗噪性能和计算效率上都有提高.%Shear-wave splitting is an important characteristic of anisotropic media. Generally, when S or P-SV waves reach to the ground through anisotropic media, the seismic record received by x component and y component of three-component detector contains fast wave and slow wave simultaneously- Separating fast wave and slow wave and then calculating the anisotropic parameters of media are an important step in multi-component data processing. The authors introduce the Pearson correlation coefficients into multi-component seismic exploration and propose the Pearson correlation coefficients to detect the rotation angle and then separate the fast wave and slow wave. Compared with the traditional cross-correlation method, the Pearson correlation coefficient method is better in accuracy, noise immunity and computational efficiency.

  1. Application of Linear Mixed-Effects Models in Human Neuroscience Research: A Comparison with Pearson Correlation in Two Auditory Electrophysiology Studies.

    Science.gov (United States)

    Koerner, Tess K; Zhang, Yang

    2017-02-27

    Neurophysiological studies are often designed to examine relationships between measures from different testing conditions, time points, or analysis techniques within the same group of participants. Appropriate statistical techniques that can take into account repeated measures and multivariate predictor variables are integral and essential to successful data analysis and interpretation. This work implements and compares conventional Pearson correlations and linear mixed-effects (LME) regression models using data from two recently published auditory electrophysiology studies. For the specific research questions in both studies, the Pearson correlation test is inappropriate for determining strengths between the behavioral responses for speech-in-noise recognition and the multiple neurophysiological measures as the neural responses across listening conditions were simply treated as independent measures. In contrast, the LME models allow a systematic approach to incorporate both fixed-effect and random-effect terms to deal with the categorical grouping factor of listening conditions, between-subject baseline differences in the multiple measures, and the correlational structure among the predictor variables. Together, the comparative data demonstrate the advantages as well as the necessity to apply mixed-effects models to properly account for the built-in relationships among the multiple predictor variables, which has important implications for proper statistical modeling and interpretation of human behavior in terms of neural correlates and biomarkers.

  2. Multimodal Teaching Principles on the Basis of Pearson Correlation Analysis%多模态教学原则Pearson相关分析

    Institute of Scientific and Technical Information of China (English)

    邓嵘

    2016-01-01

    Based on the latest research in the fields of multi-modality and multimodality teaching, this study tries to put for-ward the teaching principles on the basis of multimodality teach-ing. During the empirical study, a large number of non-English majors were divided into the contrastive class and the experi-mental class. By analysis of the results of the questionnaire and the Person Correlation Analysis of the pre-test, the mid-test and the post-test, the writer has come to the conclusion that a more harmonious multimodality platform could be constructed so that learning quality and environment could be improved as well.%本研究以多模态、多模态教学领域最新理论为基础,提出多模态教学遵循的原则.通过实证研究,某高校非英语专业学生被分为实验组和对照组,参与多模态教学原则实施过程.通过因子与Pearson 相关分析,可搭建多模态和谐平台,营造有利于提高学习积极性的学习环境.

  3. Biochemical abnormalities in Pearson syndrome.

    Science.gov (United States)

    Crippa, Beatrice Letizia; Leon, Eyby; Calhoun, Amy; Lowichik, Amy; Pasquali, Marzia; Longo, Nicola

    2015-03-01

    Pearson marrow-pancreas syndrome is a multisystem mitochondrial disorder characterized by bone marrow failure and pancreatic insufficiency. Children who survive the severe bone marrow dysfunction in childhood develop Kearns-Sayre syndrome later in life. Here we report on four new cases with this condition and define their biochemical abnormalities. Three out of four patients presented with failure to thrive, with most of them having normal development and head size. All patients had evidence of bone marrow involvement that spontaneously improved in three out of four patients. Unique findings in our patients were acute pancreatitis (one out of four), renal Fanconi syndrome (present in all patients, but symptomatic only in one), and an unusual organic aciduria with 3-hydroxyisobutyric aciduria in one patient. Biochemical analysis indicated low levels of plasma citrulline and arginine, despite low-normal ammonia levels. Regression analysis indicated a significant correlation between each intermediate of the urea cycle and the next, except between ornithine and citrulline. This suggested that the reaction catalyzed by ornithine transcarbamylase (that converts ornithine to citrulline) might not be very efficient in patients with Pearson syndrome. In view of low-normal ammonia levels, we hypothesize that ammonia and carbamylphosphate could be diverted from the urea cycle to the synthesis of nucleotides in patients with Pearson syndrome and possibly other mitochondrial disorders.

  4. Fast computation of voxel-level brain connectivity maps from resting-state functional MRI using l₁-norm as approximation of Pearson's temporal correlation: proof-of-concept and example vector hardware implementation.

    Science.gov (United States)

    Minati, Ludovico; Zacà, Domenico; D'Incerti, Ludovico; Jovicich, Jorge

    2014-09-01

    An outstanding issue in graph-based analysis of resting-state functional MRI is choice of network nodes. Individual consideration of entire brain voxels may represent a less biased approach than parcellating the cortex according to pre-determined atlases, but entails establishing connectedness for 1(9)-1(11) links, with often prohibitive computational cost. Using a representative Human Connectome Project dataset, we show that, following appropriate time-series normalization, it may be possible to accelerate connectivity determination replacing Pearson correlation with l1-norm. Even though the adjacency matrices derived from correlation coefficients and l1-norms are not identical, their similarity is high. Further, we describe and provide in full an example vector hardware implementation of l1-norm on an array of 4096 zero instruction-set processors. Calculation times <1000 s are attainable, removing the major deterrent to voxel-based resting-sate network mapping and revealing fine-grained node degree heterogeneity. L1-norm should be given consideration as a substitute for correlation in very high-density resting-state functional connectivity analyses.

  5. Correlação de pearson e análise de trilha identificando variáveis para caracterizar porta-enxerto de Pyrus communis L Pearson correlation and path analysis identifying variables for the characterization of Pyrus communis L. rootstock

    Directory of Open Access Journals (Sweden)

    Simone Padilha Galarça

    2010-08-01

    Full Text Available Objetivou-se, no presente trabalho, através de correlação de Pearson e análise de trilha, identificar variáveis para caracterizar porta-enxertos ananizantes para a cultura da pereira (Pyrus communis L.. Neste experimento foram utilizadas 49 plantas de pereira, plantadas nos canteiros do Departamento de Fitotecnia da FAEM/UFPel. As plantas foram avaliadas na época do seu crescimento vegetativo, segundo parâmetros descritos em instruções do Ministério da Agricultura, Pecuária e Abastecimento. Pela correlação de Pearson, as variáveis VP, NRP, HCP e FCNPRCL se destacaram. Na análise de trilha, a variável número de lenticelas obteve maior efeito positivo sobre VP, NRP e FCNPRCL, a variável ramificação do ramo demonstrou-se com efeito positivo sobre HCP, sendo essas duas variáveis consideradas eficazes no processo de seleção de porta-enxerto juntamente com as variáveis básicas.The objective of this work was to identify, through the Pearson correlation and path analysis, variables to characterize rootstocks suitable for the cultivation of the pear (Pyrus communis L.. In this experiment 49 pear specimens were used, planted in flowerbeds at the Phytotechny Department. The plants were evaluated at the time of growth, according to parameters described in the instructions of the Ministério da Agricultura, Pecuária e Abastecimento. According to the Pearson correlation, the variables VP, NRP, ETA and FCNPRCL stood out. In path analysis, the variable number of lenticels had a more positive effect on VP, NRP and FCNPRCL, variable branch of the industry had a more positive effect on ETA. Both variables were considered effective in the process of selection of rootstock together with the basic variables.

  6. Modules Identification in Gene Positive Networks of Hepatocellular Carcinoma Using Pearson Agglomerative Method and Pearson Cohesion Coupling Modularity

    OpenAIRE

    Hu, Jinyu; Gao, Zhiwei

    2012-01-01

    In this study, a gene positive network is proposed based on a weighted undirected graph, where the weight represents the positive correlation of the genes. A Pearson agglomerative clustering algorithm is employed to build a clustering tree, where dotted lines cut the tree from bottom to top leading to a number of subsets of the modules. In order to achieve better module partitions, the Pearson correlation coefficient modularity is addressed to seek optimal module decomposition by selecting an...

  7. Distributed lags time series analysis versus linear correlation analysis (Pearson's r) in identifying the relationship between antipseudomonal antibiotic consumption and the susceptibility of Pseudomonas aeruginosa isolates in a single Intensive Care Unit of a tertiary hospital.

    Science.gov (United States)

    Erdeljić, Viktorija; Francetić, Igor; Bošnjak, Zrinka; Budimir, Ana; Kalenić, Smilja; Bielen, Luka; Makar-Aušperger, Ksenija; Likić, Robert

    2011-05-01

    The relationship between antibiotic consumption and selection of resistant strains has been studied mainly by employing conventional statistical methods. A time delay in effect must be anticipated and this has rarely been taken into account in previous studies. Therefore, distributed lags time series analysis and simple linear correlation were compared in their ability to evaluate this relationship. Data on monthly antibiotic consumption for ciprofloxacin, piperacillin/tazobactam, carbapenems and cefepime as well as Pseudomonas aeruginosa susceptibility were retrospectively collected for the period April 2006 to July 2007. Using distributed lags analysis, a significant temporal relationship was identified between ciprofloxacin, meropenem and cefepime consumption and the resistance rates of P. aeruginosa isolates to these antibiotics. This effect was lagged for ciprofloxacin and cefepime [1 month (R=0.827, P=0.039) and 2 months (R=0.962, P=0.001), respectively] and was simultaneous for meropenem (lag 0, R=0.876, P=0.002). Furthermore, a significant concomitant effect of meropenem consumption on the appearance of multidrug-resistant P. aeruginosa strains (resistant to three or more representatives of classes of antibiotics) was identified (lag 0, R=0.992, Plags analysis and the Pearson's correlation coefficient. Correlation coefficient analysis was not able to identify relationships between antibiotic consumption and bacterial resistance when the effect was delayed. These results indicate that the use of diverse statistical methods can yield significantly different results, thus leading to the introduction of possibly inappropriate infection control measures. Copyright © 2010 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.

  8. 利用Pearson相关系数定量分析生物亲缘关系%Quantitative Analysis of the Relationship of Biology Species Using Pearson Correlation Coefficient

    Institute of Scientific and Technical Information of China (English)

    张宇镭; 党琰; 贺平安

    2005-01-01

    论文主要利用计算语言学中使用的统计学方法定量分析生物物种的亲缘关系.以包含生物体遗传信息的核酸序列为研究对象,采用计算语言学的思想和方法,将每一个生物体的核酸序列看作一篇很长的自然语言文本,抽取核酸序列的双核苷酸频率分布特征向量,用以表征其数字特征.而后采用Pearson Correlation Coefficient(Pearson相关系数)定量分析其亲缘关系的远近程度.将119个细菌的全基因组核酸序列进行两两比对,对所得的7 021个r值进行分析,得出的结论是:亲缘关系越相近的物种,其Pearson相关系数越大.取定0.985作为"属"的分界阈值时,得到召回率为75.824%,准确率为73.404%.论文对定量分析生物学核酸序列的相似性和对生物亲缘关系远近的建模有重要的实际意义.

  9. Methodological Aspects in Using Pearson Coefficient in Analyzing Social & Economical Phenomena

    OpenAIRE

    Daniela-Emanuela Danacica; Ana-Gabriela Babucea

    2007-01-01

    The authors illustrate in this paper a series of methodological aspects generated by the use of Pearson correlation coefficient in analyzing social and economical phenomena. Pearson correlation coefficient is largely used in economics and social sciences; however, the diversified nature and subtle nuances of this concept raises significant methodological issues. This article deals with aspects concerning the factors that impact on the size and interpretation of Pearson correlation coefficient...

  10. 基于Pearson相关系数的老年人社会支持与心理健康相关性研究的Meta分析%Correlation between Social Support and Mental Health of the Aged Based on Pearson Correlation Coefficient: A Meta-Analysis

    Institute of Scientific and Technical Information of China (English)

    葛芳君; 赵磊; 刘俊; 周旻馨; 郭毅; 张庆军

    2012-01-01

    Objective To reflect the correlation between social support and mental health of the aged through the Pearson correlation coefficient. Methods Databases including PubMed, SpringerLink, EMbase, The Cochrane Library, VIP, WanFang Data and CNKI were searched from inception to October, 2011 to collect literature on the correlation between social support and mental health of the aged. The studies were screened according to the inclusion and exclusion criteria. After extracting data and assessing the quality of the included studies, meta-analysis was conducted using RevMan 5.0 software. Results Of the 2 396 identified studies, 4 studies were included. The results showed that 4 studies were not high in the overall quality. The total score of social support of the elderly and its three dimensions were related to mental health. Among 9 factors associated with mental health, somatization, depression and anxiety were weakly correlated to the objective support while the others were extremely weakly correlated. Anxiety and phobic anxiety were weakly correlated to the subjective support while the others were extremely weakly correlated. Phobic anxiety was weakly correlated to the utilizing degree while the others were extremely weakly correlated. Somatization, anxiety and phobic anxiety were weakly correlated to the total score of social support while the others were extremely weakly correlated. Conclusion Social support probably improves mental health of the aged to some extent.%目的 采用Meta分析的方法,评价基于Pearson相关系数的老年人社会支持与心理健康的相关性.方法 计算机检索PubMed、Springerlink、EMbase、the Cochrane Library、VIP、WanFang Data和CNKI数据库,检索时限均为从建库至2011年10月,查找关于老年人社会支持与心理健康相关性的文献.按照纳入排除标准筛选文献、提取资料并评价纳入研究的质量后,采用RevMan 5.0软件进行Meta分析.结果 共检出相关文献2 396

  11. The standard error of the Pearson skew

    Directory of Open Access Journals (Sweden)

    Bradley Harding

    2015-02-01

    Full Text Available The Pearson skew is a measure of asymmetry of a distribution, based on the difference between the mean and the median of a distribution. Here we show how to calculate the Pearson skew, estimate its standard error and the confidence interval. The derivation is based on a population following a normal distribution. Simulations explored the validity of this expression when the normality assumption is met in comparison to when the normality assumption is not met. The standard error of the Pearson skew revealed very robust in case of non-normal populations, compared to the Fisher Skew as presented in Harding, Tremblay and Cousineau (2014.

  12. Adjusting the log-Pearson type III function to even-aged eucalyptus stands data

    Directory of Open Access Journals (Sweden)

    Daniel Henrique Breda Binoti

    2014-12-01

    Full Text Available The objective of this study is to evaluate the efficiency of the log-Pearson tipo III function to describe the diameter structure of even-aged stands, and propose a diameter distribution model using the function. The modeling function performed by the log-Pearson tipo III was compared with the modeling performed with the Weibull function. For this we used data from permanent plots of eucalyptus, located in the Midwestern region of Minas Gerais. Adherence to the functions of the data was confirmed by applying the Kolmogorov-Smirnov test (KS. The diameter distribution models used were based on models proposed by Nogueira et al. (2005 and were evaluated in terms of RMSE (% and the correlation coefficient between estimated and observed values. All fitting to the data presented adherence by the KS test. All equations fitted for the recovery of the diameter distribution showed high correlation coefficients and can be used for modeling the diameter distribution of eucalyptus.

  13. The Pearson-Readhead AGN Survey

    Science.gov (United States)

    Lister, M. L.

    2009-08-01

    The Pearson-Readhead survey of active galactic nuclei (AGN) was the first complete sample to be studied by VLBI, and was the subject of a detailed investigation by the VSOP program. We discuss the scientific findings from this unique survey, and how it has provided robust confirmation of the relativistic beaming model for AGN jets.

  14. Genetics Home Reference: Pearson marrow-pancreas syndrome

    Science.gov (United States)

    ... Health Conditions Pearson marrow-pancreas syndrome Pearson marrow-pancreas syndrome Enable Javascript to view the expand/collapse ... PDF Open All Close All Description Pearson marrow-pancreas syndrome is a severe disorder that usually begins ...

  15. Pairing Correlations at High Spins

    Science.gov (United States)

    Ma, Hai-Liang; Dong, Bao-Guo; Zhang, Yan; Fan, Ping; Yuan, Da-Qing; Zhu, Shen-Yun; Zhang, Huan-Qiao; Petrache, C. M.; Ragnarsson, I.; Carlsson, B. G.

    The pairing correcting energies at high spins in 161Lu and 138Nd are studied by comparing the results of the cranked-Nilsson-Strutinsky (CNS) and cranked-Nilsson-Strutinsky-Bogoliubov (CNSB) models. It is concluded that the Coriolis effect rather than the rotational alignment effect plays a major role in the reduction of the pairing correlations in the high spin region. Then we proposed an average pairing correction method which not only better reproduces the experimental data comparing with the CNS model but also enables a clean-cut tracing of the configurations thus the full-spin-range discussion on the various rotating bands.

  16. Polychoric/Tetrachoric Matrix or Pearson Matrix? A methodological study

    Directory of Open Access Journals (Sweden)

    Dominguez Lara, Sergio Alexis

    2014-04-01

    Full Text Available The use of product-moment correlation of Pearson is common in most studies in factor analysis in psychology, but it is known that this statistic is only applicable when the variables related are in interval scale and normally distributed, and when are used in ordinal data may to produce a distorted correlation matrix . Thus is a suitable option using polychoric/tetrachoric matrices in item-level factor analysis when the items are in level measurement nominal or ordinal. The aim of this study was to show the differences in the KMO, Bartlett`s Test and Determinant of the Matrix, percentage of variance explained and factor loadings in depression trait scale of Depression Inventory Trait - State and the Neuroticism dimension of the short form of the Eysenck Personality Questionnaire -Revised, regarding the use of matrices polychoric/tetrachoric matrices and Pearson. These instruments was analyzed with different extraction methods (Maximum Likelihood, Minimum Rank Factor Analysis, Unweighted Least Squares and Principal Components, keeping constant the rotation method Promin were analyzed. Were observed differences regarding sample adequacy measures, as well as with respect to the explained variance and the factor loadings, for solutions having as polychoric/tetrachoric matrix. So it can be concluded that the polychoric / tetrachoric matrix give better results than Pearson matrices when it comes to item-level factor analysis using different methods.

  17. Rademacher Complexity in Neyman-Pearson Classification

    Institute of Scientific and Technical Information of China (English)

    Min HAN; Di Rong CHEN; Zhao Xu SUN

    2009-01-01

    Neyman-Pearson(NP) criterion is one of the most important ways in hypothesis testing.It is also a criterion for classification. This paper addresses the problem of bounding the estimation error of NP classification, in terms of Rademacher averages. We investigate the behavior of the global and local Rademacher averages, and present new NP classification error bounds which are based on the localized averages, and indicate how the estimation error can be estimated without a priori knowledge of the class at hand.

  18. Quadrupolar magic angle spinning NMR spectra fitted using the Pearson IV function.

    Science.gov (United States)

    Mironenko, Roman M; Belskaya, Olga B; Talsi, Valentin P; Likholobov, Vladimir A

    2014-01-01

    The Pearson IV function was used to fit the asymmetric solid-state (27)Al NMR spectra of alumina based catalysts. A high convergence (correlation coefficient is no less than 0.997) between experimental and simulated spectra was achieved. The decomposition of the (27)Al NMR spectra of zinc/aluminum mixed oxides with different Zn/Al molar ratio revealed an increased fraction (6-9%) of pentacoordinated aluminum atoms in these oxides as compared to γ-Al2O3. As the Zn/Al ratio is raised, the fraction of [AlO6] octahedral units decreases, while the fraction of [AlO4] tetrahedra increases.

  19. A null model for Pearson coexpression networks.

    Science.gov (United States)

    Gobbi, Andrea; Jurman, Giuseppe

    2015-01-01

    Gene coexpression networks inferred by correlation from high-throughput profiling such as microarray data represent simple but effective structures for discovering and interpreting linear gene relationships. In recent years, several approaches have been proposed to tackle the problem of deciding when the resulting correlation values are statistically significant. This is most crucial when the number of samples is small, yielding a non-negligible chance that even high correlation values are due to random effects. Here we introduce a novel hard thresholding solution based on the assumption that a coexpression network inferred by randomly generated data is expected to be empty. The threshold is theoretically derived by means of an analytic approach and, as a deterministic independent null model, it depends only on the dimensions of the starting data matrix, with assumptions on the skewness of the data distribution compatible with the structure of gene expression levels data. We show, on synthetic and array datasets, that the proposed threshold is effective in eliminating all false positive links, with an offsetting cost in terms of false negative detected edges.

  20. A null model for Pearson coexpression networks.

    Directory of Open Access Journals (Sweden)

    Andrea Gobbi

    Full Text Available Gene coexpression networks inferred by correlation from high-throughput profiling such as microarray data represent simple but effective structures for discovering and interpreting linear gene relationships. In recent years, several approaches have been proposed to tackle the problem of deciding when the resulting correlation values are statistically significant. This is most crucial when the number of samples is small, yielding a non-negligible chance that even high correlation values are due to random effects. Here we introduce a novel hard thresholding solution based on the assumption that a coexpression network inferred by randomly generated data is expected to be empty. The threshold is theoretically derived by means of an analytic approach and, as a deterministic independent null model, it depends only on the dimensions of the starting data matrix, with assumptions on the skewness of the data distribution compatible with the structure of gene expression levels data. We show, on synthetic and array datasets, that the proposed threshold is effective in eliminating all false positive links, with an offsetting cost in terms of false negative detected edges.

  1. Modules Identification in Gene Positive Networks of Hepatocellular Carcinoma Using Pearson Agglomerative Method and Pearson Cohesion Coupling Modularity

    Directory of Open Access Journals (Sweden)

    Jinyu Hu

    2012-01-01

    Full Text Available In this study, a gene positive network is proposed based on a weighted undirected graph, where the weight represents the positive correlation of the genes. A Pearson agglomerative clustering algorithm is employed to build a clustering tree, where dotted lines cut the tree from bottom to top leading to a number of subsets of the modules. In order to achieve better module partitions, the Pearson correlation coefficient modularity is addressed to seek optimal module decomposition by selecting an optimal threshold value. For the liver cancer gene network under study, we obtain a strong threshold value at 0.67302, and a very strong correlation threshold at 0.80086. On the basis of these threshold values, fourteen strong modules and thirteen very strong modules are obtained respectively. A certain degree of correspondence between the two types of modules is addressed as well. Finally, the biological significance of the two types of modules is analyzed and explained, which shows that these modules are closely related to the proliferation and metastasis of liver cancer. This discovery of the new modules may provide new clues and ideas for liver cancer treatment.

  2. Quantifying distinct associations on different temporal scales: comparison of DCCA and Pearson methods

    Science.gov (United States)

    Piao, Lin; Fu, Zuntao

    2016-11-01

    Cross-correlation between pairs of variables takes multi-time scale characteristic, and it can be totally different on different time scales (changing from positive correlation to negative one), e.g., the associations between mean air temperature and relative humidity over regions to the east of Taihang mountain in China. Therefore, how to correctly unveil these correlations on different time scales is really of great importance since we actually do not know if the correlation varies with scales in advance. Here, we compare two methods, i.e. Detrended Cross-Correlation Analysis (DCCA for short) and Pearson correlation, in quantifying scale-dependent correlations directly to raw observed records and artificially generated sequences with known cross-correlation features. Studies show that 1) DCCA related methods can indeed quantify scale-dependent correlations, but not Pearson method; 2) the correlation features from DCCA related methods are robust to contaminated noises, however, the results from Pearson method are sensitive to noise; 3) the scale-dependent correlation results from DCCA related methods are robust to the amplitude ratio between slow and fast components, while Pearson method may be sensitive to the amplitude ratio. All these features indicate that DCCA related methods take some advantages in correctly quantifying scale-dependent correlations, which results from different physical processes.

  3. Psychological factors as correlates of underachievement among ...

    African Journals Online (AJOL)

    Psychological factors as correlates of underachievement among high achievers ... Data were collected using emotional intelligence scale (r=0.79), Academic self ... Data were analysed using pearson product moment correlation and multiple ...

  4. The Pearson diffusions: A class of statistically tractable diffusion processes

    DEFF Research Database (Denmark)

    Forman, Julie Lyng; Sørensen, Michael

    estimators are shown to be consistent and asymptotically normal. The discussion covers GMM, quasi-likelihood, and non- linear weighted least squares estimation too, and it is discussed how explicit likeli- hood or approximate likelihood inference is possible for the Pearson diffusions. A complete model....... Special attention is given to a skew t-type distribution. Explicit formulae for the conditional moments and the polynomial eigenfunctions are derived. The analyti- cal tractability is inherited by transformed Pearson diffusions, integrated Pearson diffusions, sums of Pearson diffusions, and stochastic...

  5. High correlation between performance on a virtual-reality simulator and real-life cataract surgery

    DEFF Research Database (Denmark)

    Thomsen, Ann Sofia Skou; Smith, Phillip; Subhi, Yousif

    2017-01-01

    -tracking software of cataract surgical videos with a Pearson correlation coefficient of -0.70 (p = 0.017). CONCLUSION: Performance on the EyeSi simulator is significantly and highly correlated to real-life surgical performance. However, it is recommended that performance assessments are made using multiple data......PURPOSE: To investigate the correlation in performance of cataract surgery between a virtual-reality simulator and real-life surgery using two objective assessment tools with evidence of validity. METHODS: Cataract surgeons with varying levels of experience were included in the study. All...... antitremor training, forceps training, bimanual training, capsulorhexis and phaco divide and conquer. RESULTS: Eleven surgeons were enrolled. After a designated warm-up period, the proficiency-based test on the EyeSi simulator was strongly correlated to real-life performance measured by motion...

  6. Matric variate Pearson type II-Riesz distribution

    Directory of Open Access Journals (Sweden)

    José A. Díaz-García

    2016-10-01

    Full Text Available The Pearson type II distribution is well known and is used in the general framework of real normed division algebras and Riesz distribution theory. Also, the so called Pearson type II-Riesz distribution, based on the Kotz–Riesz distribution, is presented in a unified way valid in the context of real, complex, quaternion and octonion random matrices. Specifically, the central nonsingular matric variate generalised Pearson type II-Riesz distribution and beta-Riesz type I distributions are derived in the addressed multiple numerical field settings.

  7. Karl pearson the scientific life in a statistical age

    CERN Document Server

    Porter, Theodore M

    2010-01-01

    Karl Pearson, founder of modern statistics, came to this field by way of passionate early studies of philosophy and cultural history as well as ether physics and graphical geometry. His faith in science grew out of a deeply moral quest, reflected also in his socialism and his efforts to find a new basis for relations between men and women. This biography recounts Pearson's extraordinary intellectual adventure and sheds new light on the inner life of science. Theodore Porter's intensely personal portrait of Pearson extends from religious crisis and sexual tensions to metaphysical and even m

  8. The Pearson diffusions: A class of statistically tractable diffusion processes

    DEFF Research Database (Denmark)

    Forman, Julie Lyng; Sørensen, Michael

    The Pearson diffusions is a flexible class of diffusions defined by having linear drift and quadratic squared diffusion coefficient. It is demonstrated that for this class explicit statistical inference is feasible. Explicit optimal martingale estimating func- tions are found, and the corresponding...... volatility models with Pearson volatility process. For the non-Markov models explicit optimal prediction based estimating functions are found and shown to yield consistent and asymptotically normal estimators...

  9. How accurate is the Pearson r-from-Z approximation? A Monte Carlo simulation study.

    Science.gov (United States)

    Hittner, James B; May, Kim

    2012-01-01

    The Pearson r-from-Z approximation estimates the sample correlation (as an effect size measure) from the ratio of two quantities: the standard normal deviate equivalent (Z-score) corresponding to a one-tailed p-value divided by the square root of the total (pooled) sample size. The formula has utility in meta-analytic work when reports of research contain minimal statistical information. Although simple to implement, the accuracy of the Pearson r-from-Z approximation has not been empirically evaluated. To address this omission, we performed a series of Monte Carlo simulations. Results indicated that in some cases the formula did accurately estimate the sample correlation. However, when sample size was very small (N = 10) and effect sizes were small to small-moderate (ds of 0.1 and 0.3), the Pearson r-from-Z approximation was very inaccurate. Detailed figures that provide guidance as to when the Pearson r-from-Z formula will likely yield valid inferences are presented.

  10. Karl Pearson and eugenics: personal opinions and scientific rigor.

    Science.gov (United States)

    Delzell, Darcie A P; Poliak, Cathy D

    2013-09-01

    The influence of personal opinions and biases on scientific conclusions is a threat to the advancement of knowledge. Expertise and experience does not render one immune to this temptation. In this work, one of the founding fathers of statistics, Karl Pearson, is used as an illustration of how even the most talented among us can produce misleading results when inferences are made without caution or reference to potential bias and other analysis limitations. A study performed by Pearson on British Jewish schoolchildren is examined in light of ethical and professional statistical practice. The methodology used and inferences made by Pearson and his coauthor are sometimes questionable and offer insight into how Pearson's support of eugenics and his own British nationalism could have potentially influenced his often careless and far-fetched inferences. A short background into Pearson's work and beliefs is provided, along with an in-depth examination of the authors' overall experimental design and statistical practices. In addition, portions of the study regarding intelligence and tuberculosis are discussed in more detail, along with historical reactions to their work.

  11. ANALYSIS TO NEYMAN-PEARSON CLASSIFICATION WITH CONVEX LOSS FUNCTION

    Institute of Scientific and Technical Information of China (English)

    Min Han; Dirong Chen; Zhaoxu Sun

    2008-01-01

    Neyman-Pearson classification has been studied in several articles before.But they all proceeded in the classes of indicator functions with indicator function as the loss function,which make the calculation to be difficult.This paper investigates NeymanPearson classification with convex loss function in the arbitrary class of real measurable functions.A general condition is given under which Neyman-Pearson classification with convex loss function has the same classifier as that with indicator loss function.We give analysis to NP-ERM with convex loss function and prove it's performance guarantees.An example of complexity penalty pair about convex loss function risk in terms of Rademacher averages is studied,which produces a tight PAC bound of the NP-ERM with convex loss function.

  12. Clinical manifestations and management of four children with Pearson syndrome.

    Science.gov (United States)

    Tumino, Manuela; Meli, Concetta; Farruggia, Piero; La Spina, Milena; Faraci, Maura; Castana, Cinzia; Di Raimondo, Vincenzo; Alfano, Marivana; Pittalà, Annarita; Lo Nigro, Luca; Russo, Giovanna; Di Cataldo, Andrea

    2011-12-01

    Pearson marrow-pancreas syndrome is a fatal disorder mostly diagnosed during infancy and caused by mutations of mitochondrial DNA. We hereby report on four children affected by Pearson syndrome with hematological disorders at onset. The disease was fatal to three of them and the fourth one, who received hematopoietic stem cell transplantation, died of secondary malignancy. In this latter patient transplantation corrected hematological and non-hematological issues like metabolic acidosis, and we therefore argue that it could be considered as a useful option in an early stage of the disease.

  13. Commercialising Comparison: Pearson Puts the TLC in Soft Capitalism

    Science.gov (United States)

    Hogan, Anna; Sellar, Sam; Lingard, Bob

    2016-01-01

    This paper provides a critical policy analysis of "The Learning Curve" (TLC) (2012), an initiative developed by the multinational edu-business, Pearson, in conjunction with the Economist Intelligence Unit. "TLC" exemplifies the commercialising of comparison and the efforts of edu-businesses to strategically position themselves…

  14. Commercialising Comparison: Pearson Puts the TLC in Soft Capitalism

    Science.gov (United States)

    Hogan, Anna; Sellar, Sam; Lingard, Bob

    2016-01-01

    This paper provides a critical policy analysis of "The Learning Curve" (TLC) (2012), an initiative developed by the multinational edu-business, Pearson, in conjunction with the Economist Intelligence Unit. "TLC" exemplifies the commercialising of comparison and the efforts of edu-businesses to strategically position themselves…

  15. Diffraction Correlation to Reconstruct Highly Strained Particles

    Science.gov (United States)

    Brown, Douglas; Harder, Ross; Clark, Jesse; Kim, J. W.; Kiefer, Boris; Fullerton, Eric; Shpyrko, Oleg; Fohtung, Edwin

    2015-03-01

    Through the use of coherent x-ray diffraction a three-dimensional diffraction pattern of a highly strained nano-crystal can be recorded in reciprocal space by a detector. Only the intensities are recorded, resulting in a loss of the complex phase. The recorded diffraction pattern therefore requires computational processing to reconstruct the density and complex distribution of the diffracted nano-crystal. For highly strained crystals, standard methods using HIO and ER algorithms are no longer sufficient to reconstruct the diffraction pattern. Our solution is to correlate the symmetry in reciprocal space to generate an a priori shape constraint to guide the computational reconstruction of the diffraction pattern. This approach has improved the ability to accurately reconstruct highly strained nano-crystals.

  16. Bayesian-Pearson Divergence Estimator Based on Grouped Data

    Institute of Scientific and Technical Information of China (English)

    BaoxueZhang; QingxunMeng

    2004-01-01

    A new method along with Bayesian approach for estimating the parameter in the distribution function F(x; θ) by using grouped data is developed in this paper. The support of F(x;θ) is divided into disjointed intervals as -∞ = x0 < x1 <… < xk-1 Pearson divergence D(p; q) is introduced to scale the distance between the probabilities pj(θ),j = 1,..., k and the samples from the posterior distribution (Dirichlet distribution) of the probabilities. Then by minimizing the Pearson divergence D(p;q), the ‘posterior' samples of the parameter θ can be obtained, through which statistical inference including Bayesian-Pearson Divergence Estimator of the parameter can be processed. Simulations and a numerical example emt:loying this method are presented.

  17. High correlation of double Debye model parameters in skin cancer detection.

    Science.gov (United States)

    Truong, Bao C Q; Tuan, H D; Fitzgerald, Anthony J; Wallace, Vincent P; Nguyen, H T

    2014-01-01

    The double Debye model can be used to capture the dielectric response of human skin in terahertz regime due to high water content in the tissue. The increased water proportion is widely considered as a biomarker of carcinogenesis, which gives rise of using this model in skin cancer detection. Therefore, the goal of this paper is to provide a specific analysis of the double Debye parameters in terms of non-melanoma skin cancer classification. Pearson correlation is applied to investigate the sensitivity of these parameters and their combinations to the variation in tumor percentage of skin samples. The most sensitive parameters are then assessed by using the receiver operating characteristic (ROC) plot to confirm their potential of classifying tumor from normal skin. Our positive outcomes support further steps to clinical application of terahertz imaging in skin cancer delineation.

  18. Upper bounds for Neyman-Pearson cooperative spectrum sensing

    KAUST Repository

    Zahabi, Sayed Jalal

    2011-06-01

    We consider a cooperative spectrum sensing scenario where the local sensors at the secondary users are viewed as one-level quantizers, and the quantized data are to be fused under Neyman-Pearson (N-P) criterion. We demonstrate how the N-P fusion results in a randomized test, which represents the total performance of our spectrum sensing scheme. We further introduce an upper performance bound for the overall primary user signal detection. An analytical procedure towards the upper bound and its relevant quantization setup at the local sensors are proposed and examined through simulations. © 2011 IEEE.

  19. High-fidelity coding with correlated neurons.

    Directory of Open Access Journals (Sweden)

    Rava Azeredo da Silveira

    2014-11-01

    Full Text Available Positive correlations in the activity of neurons are widely observed in the brain. Previous studies have shown these correlations to be detrimental to the fidelity of population codes, or at best marginally favorable compared to independent codes. Here, we show that positive correlations can enhance coding performance by astronomical factors. Specifically, the probability of discrimination error can be suppressed by many orders of magnitude. Likewise, the number of stimuli encoded--the capacity--can be enhanced more than tenfold. These effects do not necessitate unrealistic correlation values, and can occur for populations with a few tens of neurons. We further show that both effects benefit from heterogeneity commonly seen in population activity. Error suppression and capacity enhancement rest upon a pattern of correlation. Tuning of one or several effective parameters can yield a limit of perfect coding: the corresponding pattern of positive correlation leads to a 'lock-in' of response probabilities that eliminates variability in the subspace relevant for stimulus discrimination. We discuss the nature of this pattern and we suggest experimental tests to identify it.

  20. Performance Analysis of Distributed Neyman-Pearson Detection Systems

    Institute of Scientific and Technical Information of China (English)

    ZHAO Juan; TAO Ran; WANG Yue; ZHOU Si-yong

    2007-01-01

    The performance of a distributed Neyman-Pearson detection system is considered with the decision rules of the sensors given and the decisions from different sensors being mutually independent conditioned on both hypothese. To achieve the better performance at the fusion center for a general detection system of n>3 sensor configuration, the necessary and sufficient conditions are derived by comparing the probability of detection at the fusion center with that of each of the sensors, with the constraint that the probability of false alarm at the fusion center is equal to that of the sensor. The conditions are related with the performances of the sensors and using the results we can predict the performance at the fusion center of a distributed detection system and can choose appropriate sensors to construct efficient distributed detection systems.

  1. Green's function formalism for highly correlated systems

    Directory of Open Access Journals (Sweden)

    F.Mancini

    2006-01-01

    Full Text Available We present the Composite Operator Method (COM as a modern approach to the study of strongly correlated electronic systems, based on the equation of motion and Green's function method. COM uses propagators of composite operators as building blocks at the basis of approximate calculations and algebra constrains to fix the representation of Green's functions in order to maintain the algebraic and symmetry properties.

  2. High-order correlation of chaotic bosons and fermions

    Science.gov (United States)

    Liu, Hong-Chao

    2016-08-01

    We theoretically study the high-order correlation functions of chaotic bosons and fermions. Based on the different parity of the Stirling number, the products of the first-order correlation functions are well classified and employed to represent the high-order correlation function. The correlation of bosons conduces a bunching effect, which will be enhanced as order N increases. Different from bosons, the anticommutation relation of fermions leads to the parity of the Stirling number, which thereby results in a mixture of bunching and antibunching behaviors in high-order correlation. By further investigating third-order ghost diffraction and ghost imaging, the differences between the high-order correlations of bosons and fermions are discussed in detail. A larger N will dramatically improve the ghost image quality for bosons, but a good strategy should be carefully chosen for the fermionic ghost imaging process due to its complex correlation components.

  3. Pearson disease in an infant presenting with severe hypoplastic anemia, normal pancreatic function, and progressive liver failure.

    Science.gov (United States)

    Shapira, Adi; Konopnicki, Muriel; Hammad-Saied, Mohammed; Shabad, Evelyn

    2014-07-01

    Pearson disease is a rare, usually fatal, mitochondrial disorder affecting primarily the bone marrow and the exocrine pancreas. We report a previously healthy 10-week-old girl who presented with profound macrocytic anemia followed by pancytopenia, synthetic liver dysfunction with liver steatosis, and metabolic acidosis with high lactate levels. She had no pancreatic involvement. Multiple cytoplasmic vacuoles in myelocytes and monocytes were seen upon microscopic evaluation of the bone marrow. Genetic analysis of the mitochondrial genome revealed a 5 kbp deletion, thus establishing the diagnosis of Pearson disease.

  4. Fluctuations and correlations in high temperature QCD

    CERN Document Server

    Bellwied, R; Fodor, Z; Katz, S D; Pasztor, A; Ratti, C; Szabo, K K

    2015-01-01

    We calculate second- and fourth-order cumulants of conserved charges in a temperature range stretching from the QCD transition region towards the realm of (resummed) perturbation theory. We perform lattice simulations with staggered quarks; the continuum extrapolation is based on $N_t=10\\dots24$ in the crossover-region and $N_t=8\\dots16$ at higher temperatures. We find that the Hadron Resonance Gas model predictions describe the lattice data rather well in the confined phase. At high temperatures (above $\\sim$250 MeV) we find agreement with the three-loop Hard Thermal Loop results.

  5. Mining Non-Redundant High Order Correlations in Binary Data.

    Science.gov (United States)

    Zhang, Xiang; Pan, Feng; Wang, Wei; Nobel, Andrew

    2008-08-01

    Many approaches have been proposed to find correlations in binary data. Usually, these methods focus on pair-wise correlations. In biology applications, it is important to find correlations that involve more than just two features. Moreover, a set of strongly correlated features should be non-redundant in the sense that the correlation is strong only when all the interacting features are considered together. Removing any feature will greatly reduce the correlation.In this paper, we explore the problem of finding non-redundant high order correlations in binary data. The high order correlations are formalized using multi-information, a generalization of pairwise mutual information. To reduce the redundancy, we require any subset of a strongly correlated feature subset to be weakly correlated. Such feature subsets are referred to as Non-redundant Interacting Feature Subsets (NIFS). Finding all NIFSs is computationally challenging, because in addition to enumerating feature combinations, we also need to check all their subsets for redundancy. We study several properties of NIFSs and show that these properties are useful in developing efficient algorithms. We further develop two sets of upper and lower bounds on the correlations, which can be incorporated in the algorithm to prune the search space. A simple and effective pruning strategy based on pair-wise mutual information is also developed to further prune the search space. The efficiency and effectiveness of our approach are demonstrated through extensive experiments on synthetic and real-life datasets.

  6. Positive Correlation Between Academic Library Services and High-Impact Practices for

    Directory of Open Access Journals (Sweden)

    Saori Wendy Herman, MLIS, AHIP

    2016-03-01

    Full Text Available Objective – To investigate the perceived alignment between academic library services and high-impact practices (HIPs that affect student retention. Design – Survey questionnaire. Setting – Public comprehensive universities in the United States of America with a Carnegie classification of master’s level as of January 2013. Subjects – 68 library deans or directors out of the 271 who were originally contacted. Methods – The author used Qualtrics software to create a survey based on the HIPs, tested the survey for reliability, and then distributed it to 271 universities. Library services were grouped into 1 of 3 library scales: library collection, library instruction, or library facilities. The survey consisted of a matrix of 10 Likert-style questions addressing the perceived level of alignment between the library scales and the HIPs. Each question provided an opportunity for the respondent to enter a “brief description of support practices” (p 477. Additional demographic questions addressed the years of experience of the respondent, undergraduate student enrollment of the university, and whether librarians held faculty rank. Main Results – The author measured Pearson correlation coefficients and found a positive correlation between the library scales and the HIPs. All three library scales displayed a moderately strong positive correlation between first-year seminars and experiences (HIP 1, common intellectual experiences (HIP 2, writing-intensive courses (HIP 4, undergraduate research (HIP 6, diversity and global learning (HIP 7, service learning and community-based learning (HIP 8, internships (HIP 9, and capstone courses and projects (HIP 10. The library collections scale and library facilities scale displayed a moderately strong correlation with learning communities (HIP 3 and collaborative assignments and projects (HIP 5. The library instruction scale displayed a strong positive correlation with HIP 3 and a very strong

  7. Entropy measure of credit risk in highly correlated markets

    Science.gov (United States)

    Gottschalk, Sylvia

    2017-07-01

    We compare the single and multi-factor structural models of corporate default by calculating the Jeffreys-Kullback-Leibler divergence between their predicted default probabilities when asset correlations are either high or low. Single-factor structural models assume that the stochastic process driving the value of a firm is independent of that of other companies. A multi-factor structural model, on the contrary, is built on the assumption that a single firm's value follows a stochastic process correlated with that of other companies. Our main results show that the divergence between the two models increases in highly correlated, volatile, and large markets, but that it is closer to zero in small markets, when asset correlations are low and firms are highly leveraged. These findings suggest that during periods of financial instability, when asset volatility and correlations increase, one of the models misreports actual default risk.

  8. HIV Prevalence Correlates with High-Risk Sexual Behavior in Ethiopia's Regions.

    Directory of Open Access Journals (Sweden)

    Chris R Kenyon

    Full Text Available HIV prevalence varies between 0.9 and 6.5% in Ethiopia's eleven regions. Little has been published examining the reasons for this variation.We evaluated the relationship between HIV prevalence by region and a range of risk factors in the 2005 and 2011 Ethiopian Demographic Health Surveys. Pearson's correlation was used to assess the relationship between HIV prevalence and each variable.There was a strong association between HIV prevalence and three markers of sexual risk: mean lifetime number of partners (men: r = 0.87; P < 0.001; women: r = 0.60; P = 0.05; reporting sex with a non-married, non-cohabiting partner (men: r = 0.92; P < 0.001, women r = 0.93; P < 0.001; and premarital sex. Condom usage and HIV testing were positively associated with HIV prevalence, while the prevalence of circumcision, polygamy, age at sexual debut and male migration were not associated with HIV prevalence.Variation in sexual behavior may contribute to the large variations in HIV prevalence by region in Ethiopia. Population-level interventions to reduce risky sexual behavior in high HIV incidence regions should be considered.

  9. Management Of Large Scale Osmotic Dehydration Solution Using The Pearsons Square Algorithm

    Directory of Open Access Journals (Sweden)

    Oladejo Duduyemi

    2015-01-01

    Full Text Available ABSTRACT Osmotic dehydration is a widely researched and advantageous pre-treatment process in food preservation but has not enjoyed industrial acceptance because if its highly concentrated and voluminous effluent. The Pearsons square algorithm was employed to give a focussed attack to the problem by developing a user-friendly template for reconstituting effluents for recycling purposes using Java script programme. Outflow from a pilot scale plant was reactivated and introduced into a scheme of operation for continuous OD of fruits and vegetables. Screened and re-concentrated effluent were subjected to statistical analysis in comparison to initial concentrations solution at confidence limit of p0.05. The template proven to be an adequate representation of the Pearsons square algorithm it is sufficiently good in reconstituting used osmotic solutions for repetitive usage. This protocol if adopted in the industry is not only environmentally friendly but also promises significant economic improvement of OD process. Application Recycling of non-reacting media and as a template for automation in continuous OD processing.

  10. Pearson's syndrome: a rare cause of non-immune hydrops fetalis

    Institute of Scientific and Technical Information of China (English)

    李澤荷; 林青雲; 李志偉; 鄺毅山; 司徒紹昌

    2003-01-01

    @@ Pearson's syndrome, or Pearson's marrow-pancreas syndrome, was first described in 1979 in four unrelated children.1 It is characterized by refractory sideroblastic anaemia with vacuolization of marrow progenitor cells, and exocrine pancreatic dysfunction. Its progressive nature, multisystem involvement and metabolic disturbances led to the subsequent identification of a unique mitochondrial DNA deletion in most affected patients.2 Despite the relentless clinical course, the majority of the patients with Pearson ' s syndrome present insidiously. Life-threatening presentation at birth is extremely rare. We report a case of Pearson ' s syndrome presenting with severe hydrops fetalis.

  11. Time correlations of high energy muons in an underground detector

    CERN Document Server

    Becherini, Y; Chiarusi, T; Cozzi, M; Dekhissi, H; Derkaoui, J; Esposito, L S; Giacomelli, G; Giglietto, N; Giorgini, M; Maaroufi, F; Mandrioli, G; Manzoor, S; Margiotta, A; Moussa, A

    2005-01-01

    We present the result of a search for correlations in the arrival times of high energy muons collected from 1995 till 2000 with the streamer tube system of the complete MACRO detector at the underground Gran Sasso Lab. Large samples of single muons (8.6 million), double muons (0.46 million) and multiple muons with multiplicities from 3 to 6 (0.08 million) were selected. These samples were used to search for time correlations of cosmic ray particles coming from the whole upper hemisphere or from selected space cones. The results of our analyses confirm with high statistics a random arrival time distribution of high energy cosmic rays.

  12. Long-range correlations in high multiplicity and collisions

    Indian Academy of Sciences (India)

    Gunther Roland

    2015-05-01

    This review summarizes recent discoveries in high-energy proton+proton and proton+nucleus collisions, with particular attention on the observation of long-range azimuthal correlations in high multiplicity collisions. These correlations, which resemble those seen in ultrarelativistic nucleus–nucleus collisions, provide a unique window into the physics of the very early collision stage in high energy nuclear interactions. Here we present a compilation of the most important experimental results and briefly discuss successes and challenges for a selection of theoretical approaches.

  13. High-speed image matching with coaxial holographic optical correlator

    Science.gov (United States)

    Ikeda, Kanami; Watanabe, Eriko

    2016-09-01

    A computation speed of more than 100 Gbps is experimentally demonstrated using our developed ultrahigh-speed optical correlator. To verify this high computation speed practically, the computation speeds of our optical correlator and conventional digital image matching are quantitatively compared. We use a population count function that achieves the fastest calculation speed when calculating binary matching by a central processing unit (CPU). The calculation speed of the optical correlator is dramatically faster than that using a CPU (2.40 GHz × 4) and 16 GB of random access memory, especially when the calculation data are large-scale.

  14. correlation of magnetic resonance imaging findings with arthroscopy ...

    African Journals Online (AJOL)

    clinically diagnosed rotator cuff disease based upon the radiologist's interpretation with actual intra- operative arthroscopic ... invasively display high definition anatomy images ... surgical correlation (4) enough to guide on the treatment ..... Sex. Pearson. Correlation. 0.251. -0.182. -0.182. 0.156. -0.289. 0.061. 0.156. -0.052.

  15. Trouble shooting for covariance fitting in highly correlated data

    CERN Document Server

    Yoon, Boram; Lee, Weonjong; Jung, Chulwoo

    2011-01-01

    We report a possible solution to the trouble that the covariance fitting fails when the data is highly correlated and the covariance matrix has small eigenvalues. As an example, we choose the data analysis of highly correlated $B_K$ data on the basis of the SU(2) staggered chiral perturbation theory. Basically, the essence of the problem is that we do not have an accurate fitting function so that we cannot fit the highly correlated and precise data. When some eigenvalues of the covariance matrix are small, even a tiny error of fitting function can produce large chi-square and spoil the fitting procedure. We have applied a number of prescriptions available in the market such as diagonal approximation and cutoff method. In addition, we present a new method, the eigenmode shift method which fine-tunes the fitting function while keeping the covariance matrix untouched.

  16. On some hydrogen bond correlations at high pressures

    Science.gov (United States)

    Sikka, S. K.

    2007-09-01

    In situ high pressure neutron diffraction measured lengths of O H and H O pairs in hydrogen bonds in substances are shown to follow the correlation between them established from 0.1 MPa data on different chemical compounds. In particular, the conclusion by Nelmes et al that their high pressure data on ice VIII differ from it is not supported. For compounds in which the O H stretching frequencies red shift under pressure, it is shown that wherever structural data is available, they follow the stretching frequency versus H O (or O O) distance correlation. For compounds displaying blue shifts with pressure an analogy appears to exist with improper hydrogen bonds.

  17. Score Correlation

    OpenAIRE

    Fabián, Z. (Zdeněk)

    2010-01-01

    In this paper, we study a distribution-dependent correlation coefficient based on the concept of scalar score. This new measure of association of continuous random variables is compared by means of simulation experiments with the Pearson, Kendall and Spearman correlation coefficients.

  18. High Temperature, high pressure equation of state density correlations and viscosity correlations

    Energy Technology Data Exchange (ETDEWEB)

    Tapriyal, D.; Enick, R.; McHugh, M.; Gamwo, I.; Morreale, B.

    2012-07-31

    Global increase in oil demand and depleting reserves has derived a need to find new oil resources. To find these untapped reservoirs, oil companies are exploring various remote and harsh locations such as deep waters in Gulf of Mexico, remote arctic regions, unexplored deep deserts, etc. Further, the depth of new oil/gas wells being drilled has increased considerably to tap these new resources. With the increase in the well depth, the bottomhole temperature and pressure are also increasing to extreme values (i.e. up to 500 F and 35,000 psi). The density and viscosity of natural gas and crude oil at reservoir conditions are critical fundamental properties required for accurate assessment of the amount of recoverable petroleum within a reservoir and the modeling of the flow of these fluids within the porous media. These properties are also used to design appropriate drilling and production equipment such as blow out preventers, risers, etc. With the present state of art, there is no accurate database for these fluid properties at extreme conditions. As we have begun to expand this experimental database it has become apparent that there are neither equations of state for density or transport models for viscosity that can be used to predict these fundamental properties of multi-component hydrocarbon mixtures over a wide range of temperature and pressure. Presently, oil companies are using correlations based on lower temperature and pressure databases that exhibit an unsatisfactory predictive capability at extreme conditions (e.g. as great as {+-} 50%). From the perspective of these oil companies that are committed to safely producing these resources, accurately predicting flow rates, and assuring the integrity of the flow, the absence of an extensive experimental database at extreme conditions and models capable of predicting these properties over an extremely wide range of temperature and pressure (including extreme conditions) makes their task even more daunting.

  19. Read-only high accuracy volume holographic optical correlator

    Science.gov (United States)

    Zhao, Tian; Li, Jingming; Cao, Liangcai; He, Qingsheng; Jin, Guofan

    2011-10-01

    A read-only volume holographic correlator (VHC) is proposed. After the recording of all of the correlation database pages by angular multiplexing, a stand-alone read-only high accuracy VHC will be separated from the VHC recording facilities which include the high-power laser and the angular multiplexing system. The stand-alone VHC has its own low power readout laser and very compact and simple structure. Since there are two lasers that are employed for recording and readout, respectively, the optical alignment tolerance of the laser illumination on the SLM is very sensitive. The twodimensional angular tolerance is analyzed based on the theoretical model of the volume holographic correlator. The experimental demonstration of the proposed read-only VHC is introduced and discussed.

  20. High tibial slope correlates with increased posterior tibial translation in healthy knees.

    Science.gov (United States)

    Schatka, Imke; Weiler, Andreas; Jung, Tobias M; Walter, Thula C; Gwinner, Clemens

    2017-09-09

    Notwithstanding the importance of the tibial slope (TS) for anterior tibial translation, little information is available regarding the implications on posterior laxity, particularly in healthy subjects. It was hypothesized that increased TS is associated with decreased posterior tibial translation (PTT) in healthy knees. A total of 124 stress radiographs of healthy knees were enrolled in this study. Tibial slope and the posterior tibial translation were evaluated using a Telos device with a 150-N force at 90° of knee flexion. Two blinded observers reviewed independently on two different occasions. One hundred and twenty-four patients [35 females and 89 males; 41 (range 18-75) years] were enrolled in this study, with a mean PTT of 2.8 mm (±1.9 mm; range 0-8 mm) and a mean TS of 8.6° (±2.6°; range 1°-14°). Pearson correlation showed a significant correlation between the PTT and TS in the overall patient cohort (P < 0.0001) with r = 0.76 and R (2) = 0.58. There was no statistical difference between female and male patients regarding the PTT or the TS. Subgrouping of the patient cohort (four groups with n = 31) according to their TS (groups I < 7°; II = 7°-8.5°; III = 9°-10.5°; IV ≥ 11°) revealed significant differences between each subgroup, respectively. Furthermore, there was a weak but significant correlation between age and PTT (P = 0.004, r = 0.26). In addition to the substantial variance in tibial slope and posterior laxity among healthy knees, high tibial slope significantly correlates with increased posterior tibial translation. Increasing age is further associated with a greater magnitude of posterior tibial translation. Consequently, knowledge of the tibial slope facilitates simple estimation of posterior knee laxity, which is mandatory for PCL reconstruction and knee arthroplasty.

  1. Correlations and fluctuations in high energy heavy ion collision experiments

    Institute of Scientific and Technical Information of China (English)

    ZHOU Dai-Mei; WANG Ya-Ping; WEI Li-Hua; CAI Xu

    2008-01-01

    An overview of research status of soft physics in high energy heavy-ion collision experiments and recent experimental results are presented.The experimental status on fluctuations and correlations has been reviewed and the outlook for research status of soft physics in LHC/ALICE has been introduced in this paper.

  2. Alternative High School Students: Prevalence and Correlates of Overweight

    Science.gov (United States)

    Kubik, Martha Y.; Davey, Cynthia; Fulkerson, Jayne A.; Sirard, John; Story, Mary; Arcan, Chrisa

    2009-01-01

    Objective: To determine prevalence and correlates of overweight among adolescents attending alternative high schools (AHS). Methods: AHS students (n=145) from 6 schools completed surveys and anthropometric measures. Cross-sectional associations were assessed using mixed model multivariate logistic regression. Results: Among students, 42% were…

  3. Inference for High-dimensional Differential Correlation Matrices.

    Science.gov (United States)

    Cai, T Tony; Zhang, Anru

    2016-01-01

    Motivated by differential co-expression analysis in genomics, we consider in this paper estimation and testing of high-dimensional differential correlation matrices. An adaptive thresholding procedure is introduced and theoretical guarantees are given. Minimax rate of convergence is established and the proposed estimator is shown to be adaptively rate-optimal over collections of paired correlation matrices with approximately sparse differences. Simulation results show that the procedure significantly outperforms two other natural methods that are based on separate estimation of the individual correlation matrices. The procedure is also illustrated through an analysis of a breast cancer dataset, which provides evidence at the gene co-expression level that several genes, of which a subset has been previously verified, are associated with the breast cancer. Hypothesis testing on the differential correlation matrices is also considered. A test, which is particularly well suited for testing against sparse alternatives, is introduced. In addition, other related problems, including estimation of a single sparse correlation matrix, estimation of the differential covariance matrices, and estimation of the differential cross-correlation matrices, are also discussed.

  4. On discriminant analysis techniques and correlation structures in high dimensions

    DEFF Research Database (Denmark)

    Clemmensen, Line Katrine Harder

    This paper compares several recently proposed techniques for performing discriminant analysis in high dimensions, and illustrates that the various sparse methods dier in prediction abilities depending on their underlying assumptions about the correlation structures in the data. The techniques...... generally focus on two things: Obtaining sparsity (variable selection) and regularizing the estimate of the within-class covariance matrix. For high-dimensional data, this gives rise to increased interpretability and generalization ability over standard linear discriminant analysis. Here, we group...

  5. Mitochondrial DNA deletion in a patient with combined features of Leigh and Pearson syndromes

    Energy Technology Data Exchange (ETDEWEB)

    Blok, R.B.; Thorburn, D.R.; Danks, D.M. [Royal Children`s Hospital, Melbourne (Australia)] [and others

    1994-09-01

    We describe a heteroplasmic 4237 bp mitochondrial DNA (mtDNA) deletion in an 11 year old girl who has suffered from progressive illness since birth. She has some features of Leigh syndrome (global developmental delay with regression, brainstem dysfunction and lactic acidosis), together with other features suggestive of Pearson syndrome (history of pancytopenia and failure to thrive). The deletion was present at a level greater than 50% in skeletal muscle, but barely detectable in skin fibroblasts following Southern blot analysis, and only observed in blood following PCR analysis. The deletion spanned nt 9498 to nt 13734, and was flanked by a 12 bp direct repeat. Genes for cytochrome c oxidase subunit III, NADH dehydrogenase subunits 3, 4L, 4 and 5, and tRNAs for glycine, arginine, histidine, serine({sup AGY}) and leucine({sup CUN}) were deleted. Southern blotting also revealed an altered Apa I restriction site which was shown by sequence analysis to be caused by G{r_arrow}A nucleotide substitution at nt 1462 in the 12S rRNA gene. This was presumed to be a polymorphism. No abnormalities of mitochondrial ultrastructure, distribution or of respiratory chain enzyme complexes I-IV in skeletal muscle were observed. Mitochondrial disorders with clinical features overlapping more than one syndrome have been reported previously. This case further demonstrates the difficulty in correlating observed clinical features with a specific mitochondrial DNA mutation.

  6. [Calculating Pearson residual in logistic regressions: a comparison between SPSS and SAS].

    Science.gov (United States)

    Xu, Hao; Zhang, Tao; Li, Xiao-song; Liu, Yuan-yuan

    2015-01-01

    To compare the results of Pearson residual calculations in logistic regression models using SPSS and SAS. We reviewed Pearson residual calculation methods, and used two sets of data to test logistic models constructed by SPSS and STATA. One model contained a small number of covariates compared to the number of observed. The other contained a similar number of covariates as the number of observed. The two software packages produced similar Pearson residual estimates when the models contained a similar number of covariates as the number of observed, but the results differed when the number of observed was much greater than the number of covariates. The two software packages produce different results of Pearson residuals, especially when the models contain a small number of covariates. Further studies are warranted.

  7. "It was a young man's life": G.A. Pearson (P-53)

    Science.gov (United States)

    Susan D. Olberding

    2008-01-01

    The nation's initial USFS research site commenced in a rustic cabin in the midst of northern Arizona’s expansive ponderosa pine forest. Gustaf A. Pearson was the first in a distinguished line of USFS scientists to live and study there. A visitor to Fort Valley today often wishes he could have stood in Pearson's large boots (he was said to have enormous feet)...

  8. A Tale of Two Electrons: Correlation at High Density

    CERN Document Server

    Loos, Pierre-François

    2010-01-01

    We review our recent progress in the determination of the high-density correlation energy $\\Ec$ in two-electron systems. Several two-electron systems are considered, such as the well known helium-like ions (helium), and the Hooke's law atom (hookium). We also present results regarding two electrons on the surface of a sphere (spherium), and two electrons trapped in a spherical box (ballium). We also show that, in the large-dimension limit, the high-density correlation energy of two opposite-spin electrons interacting {\\em via} a Coulomb potential is given by $\\Ec \\sim -1/(8D^2)$ for any radial external potential $V(r)$, where $D$ is the dimensionality of the space. This result explains the similarity of $\\Ec$ in the previous two-electron systems for $D=3$.

  9. Covariance fitting of highly correlated $B_K$ data

    CERN Document Server

    Yoon, Boram; Jung, Chulwoo; Lee, Weonjong

    2011-01-01

    We present the reason why we use the diagonal approximation (uncorrelated fitting) when we perform the data analysis of highly correlated $B_K$ data on the basis of the SU(2) staggered chiral perturbation theory. Basically, the essence of the problem is that we do not have enough statistics to determine the small eigenvalues of the covariance matrix with a high precision. As a result, we have the smallest eigenvalue, which is smaller than the statistical error of the covariance matrix, corresponding to an unphysical eigenmode. We have applied a number of prescriptions available in the market such as the cutoff method and modified covariance matrix method. It turns out that the cutoff method is not a good prescription and the modified covariance matrix method is an even worse one. The diagonal approximation turns out to be a good prescription if the data points are somehow correlated and the statistics are relatively poor.

  10. Dynamics of Coulomb correlations in semiconductors in high magnetic fields

    Energy Technology Data Exchange (ETDEWEB)

    Fromer, Neil Alan [Univ. of California, Berkeley, CA (United States)

    2002-01-01

    Current theories have been successful in explaining many nonlinear optical experiments in undoped semiconductors. However, these theories require a ground state which is assumed to be uncorrelated. Strongly correlated systems of current interest, such as a two dimensional electron gas in a high magnetic field, cannot be explained in this manner because the correlations in the ground state and the low energy collective excitations cause a breakdown of the conventional techniques. We perform ultrafast time-resolved four-wave mixing on $n$-modulation doped quantum wells, which contain a quasi-two dimensional electron gas, in a large magnetic field, when only a single Landau level is excited and also when two levels are excited together. We find evidence for memory effects and as strong coupling between the Landau levels induced by the electron gas. We compare our results with simulations based on a new microscopic approach capable of treating the collective effects and correlations of the doped electrons, and find a good qualitative agreement. By looking at the individual contributions to the model, we determine that the unusual correlation effects seen in the experiments are caused by the scattering of photo-excited electron-hole pairs with the electron gas, leading to new excited states which are not present in undoped semiconductors, and also by exciton-exciton interactions mediated by the long-lived collective excitations of the electron gas, inter-Landau level magnetoplasmons.

  11. Dynamics of Coulomb correlations in semiconductors in high magnetic fields

    Energy Technology Data Exchange (ETDEWEB)

    Fromer, Neil Alan

    2002-05-01

    Current theories have been successful in explaining many nonlinear optical experiments in undoped semiconductors. However, these theories require a ground state which is assumed to be uncorrelated. Strongly correlated systems of current interest, such as a two dimensional electron gas in a high magnetic field, cannot be explained in this manner because the correlations in the ground state and the low energy collective excitations cause a breakdown of the conventional techniques. We perform ultrafast time-resolved four-wave mixing on $n$-modulation doped quantum wells, which contain a quasi-two dimensional electron gas, in a large magnetic field, when only a single Landau level is excited and also when two levels are excited together. We find evidence for memory effects and as strong coupling between the Landau levels induced by the electron gas. We compare our results with simulations based on a new microscopic approach capable of treating the collective effects and correlations of the doped electrons, and find a good qualitative agreement. By looking at the individual contributions to the model, we determine that the unusual correlation effects seen in the experiments are caused by the scattering of photo-excited electron-hole pairs with the electron gas, leading to new excited states which are not present in undoped semiconductors, and also by exciton-exciton interactions mediated by the long-lived collective excitations of the electron gas, inter-Landau level magnetoplasmons.

  12. Two-dimensional, high spatial resolution, solar spectroscopy using a correlation tracker. I. Correlation tracker description.

    Science.gov (United States)

    Ballesteros, E.; Collados, M.; Bonet, J. A.; Lorenzo, F.; Viera, T.; Reyes, M.; Rodriguez Hidalgo, I.

    1996-02-01

    In this paper the description of the Solar Correlation Tracker prototype built by the Instituto de Astrof isica de Canarias is presented. The system is mainly conceived as a solar image tranquilizer, although a scanning utility has also been included in order to displace the image on the final focal plane with sub-arcsecond steps, thus allowing to perform two-dimensional high spatial resolution spectroscopy. The behaviour of the different elements of the tracker is shown, as well as their influence in the performance of the system. The restrictions of the Absolute Differences algorithm, used to detect image motion when granulation fields are considered, are extensively discussed. Laboratory and telescope tests have demonstrated the capabilities of the system. The electronic components have been adapted to new optics and mechanics developed at the Kiepenheuer Institut to build an Advanced Solar Correlation Tracker. The final version of the system has been installed at the German VTT of the Spanish Observatorio del Teide. The tests carried out have demonstrated that a bandwidth of about 60Hz (for an attenuation factor of two) is achieved, which is approximately four times larger than that of previous Correlation Trackers, at the same level of attenuation.

  13. High-harmonic generation enhanced by dynamical electron correlation

    CERN Document Server

    Tikhomirov, Iliya; Ishikawa, Kenichi L

    2016-01-01

    We theoretically study multielectron effects in high-harmonic generation (HHG), using all-electron first-principles simulations for a one-dimensional (1D) model atom. In addition to usual plateau and cutoff (from a cation in the present case, since the neutral is immediately ionized), we find a prominent resonance peak far above the plateau and a second plateau extended beyond the first cutoff. These features originate from the dication response enhanced by orders of magnitude due to the action of the Coulomb force from the rescattering electron, and, hence, are a clear manifestation of electron correlation. Although the present simulations are done in 1D, the physical mechanism underlying the dramatic enhancement is expected to hold also for three-dimensional real systems. This will provide new possibilities to explore dynamical electron correlation in intense laser fields using HHG, which is usually considered to be of single-electron nature in most cases.

  14. SPIDER Progress Towards High Resolution Correlated Fission Product Data

    Science.gov (United States)

    Shields, Dan; Meierbachtol, Krista; Tovesson, Fredrik; Arnold, Charles; Blackeley, Rick; Bredeweg, Todd; Devlin, Matt; Hecht, Adam; Jandel, Marian; Jorgenson, Justin; Nelson, Ron; White, Morgan; Spider Team

    2014-09-01

    The SPIDER detector (SPectrometer for Ion DEtermination in fission Research) is under development with the goal of obtaining high-resolution, high-efficiency, correlated fission product data needed for many applications including the modeling of next generation nuclear reactors, stockpile stewardship, and the fundamental understanding of the fission process. SPIDER simultaneously measures velocity and energy of both fission products to calculate fission product yields (FPYs), neutron multiplicity (ν), and total kinetic energy (TKE). A detailed description of the prototype SPIDER detector components will be presented. Characterization measurements with alpha and spontaneous fission sources will also be discussed. LA-UR-14-24875. The SPIDER detector (SPectrometer for Ion DEtermination in fission Research) is under development with the goal of obtaining high-resolution, high-efficiency, correlated fission product data needed for many applications including the modeling of next generation nuclear reactors, stockpile stewardship, and the fundamental understanding of the fission process. SPIDER simultaneously measures velocity and energy of both fission products to calculate fission product yields (FPYs), neutron multiplicity (ν), and total kinetic energy (TKE). A detailed description of the prototype SPIDER detector components will be presented. Characterization measurements with alpha and spontaneous fission sources will also be discussed. LA-UR-14-24875. This work is in part supported by LANL Laboratory Directed Research and Development Projects 20110037DR and 20120077DR.

  15. Statistical analysis of highly correlated systems in biology and physics

    Science.gov (United States)

    Martin, Hector Garcia

    In this dissertation, I present my work on the statistical study of highly correlated systems in three fields of science: ecology, microbial ecology and physics. I propose an explanation for how the highly correlated distribution of species individuals, and an abundance distribution commonly observed in ecological systems, give rise to a power law dependence between a given area and the number of unique species it harbors. This is one of the oldest known ecological patterns: the power-law Species Area Rule. As a natural extension of my studies in ecology, I have undertaken both theoretical research and field work in the developing field of microbial ecology. In particular, I participated in a multidisciplinary study of the impact of microbes on the formation of macroscopic calcium carbonate terraces at Yellowstone National Park Hot Springs. I have used ecological techniques to characterize the biodiversity of our study site and developed a new bootstrap method for extracting abundance information from clone libraries. This has singled out the most abundant microorganisms and paved the way for future studies of the possible non-passive role of microorganisms in carbonate precipitation. The third part of my thesis uses statistical techniques to explore the correlations in rotating Bose-Einstein condensates. I have used finite difference techniques to solve the Gross-Pitaevskii equation in order to obtain the structure of a vortex in a lattice. Surprisingly, I have found that, in order to understand this structure, it is necessary to add a correction to the Gross-Pitaevskii equation which introduces a dependence on the particle scattering length. I have also used Path Integral Monte Carlo techniques to explore the limit of rapid rotations, where the Gross-Pitaevskii equation is no longer valid. Interestingly, the Gross-Pitaevskii equation seems to be valid for much higher densities than expected if properly renormalized. I show that, in accord with the prediction of

  16. Suicidal ideation in high school students: depression and other correlates.

    Science.gov (United States)

    De Man, A F; Leduc, C P

    1995-03-01

    English-Canadian high school students (129 boys, 117 girls) participated in a study of the relationship between suicidal ideation and selected personal variables, stress, and social support. Associations were found between suicidal ideation and the variables of gender, self-esteem, locus of control, depression, drug use, stress, perception of health, family status, academic performance, social support, and anomie. Multiple regression analysis identified depression and alcohol use as best individual predictors among these variables. Semi-partial correlation analyses showed that removal of the effect of depression resulted in a loss of initially significant relationships between suicidal ideation and the other variables except for alcohol use, drug use, and health satisfaction.

  17. Parameter estimation for the Pearson type 3 distribution using order statistics

    Science.gov (United States)

    Rocky Durrans, S.

    1992-05-01

    The Pearson type 3 distribution and its relatives, the log Pearson type 3 and gamma family of distributions, are among the most widely applied in the field of hydrology. Parameter estimation for these distributions has been accomplished using the method of moments, the methods of mixed moments and generalized moments, and the methods of maximum likelihood and maximum entropy. This study evaluates yet another estimation approach, which is based on the use of the properties of an extreme-order statistic. Based on the hypothesis that the population is distributed as Pearson type 3, this estimation approach yields both parameter and 100-year quantile estimators that have lower biases and variances than those of the method of moments approach as recommended by the US Water Resources Council.

  18. Principal components in the discrimination of outliers: A study in simulation sample data corrected by Pearson's and Yates´s chi-square distance

    Directory of Open Access Journals (Sweden)

    Manoel Vitor de Souza Veloso

    2016-04-01

    Full Text Available Current study employs Monte Carlo simulation in the building of a significance test to indicate the principal components that best discriminate against outliers. Different sample sizes were generated by multivariate normal distribution with different numbers of variables and correlation structures. Corrections by chi-square distance of Pearson´s and Yates's were provided for each sample size. Pearson´s correlation test showed the best performance. By increasing the number of variables, significance probabilities in favor of hypothesis H0 were reduced. So that the proposed method could be illustrated, a multivariate time series was applied with regard to sales volume rates in the state of Minas Gerais, obtained in different market segments.

  19. Comparing dependent robust correlations.

    Science.gov (United States)

    Wilcox, Rand R

    2016-11-01

    Let r1 and r2 be two dependent estimates of Pearson's correlation. There is a substantial literature on testing H0  : ρ1  = ρ2 , the hypothesis that the population correlation coefficients are equal. However, it is well known that Pearson's correlation is not robust. Even a single outlier can have a substantial impact on Pearson's correlation, resulting in a misleading understanding about the strength of the association among the bulk of the points. A way of mitigating this concern is to use a correlation coefficient that guards against outliers, many of which have been proposed. But apparently there are no results on how to compare dependent robust correlation coefficients when there is heteroscedasicity. Extant results suggest that a basic percentile bootstrap will perform reasonably well. This paper reports simulation results indicating the extent to which this is true when using Spearman's rho, a Winsorized correlation or a skipped correlation.

  20. On temporal correlations in high-resolution frequency counting

    CERN Document Server

    Dunker, Tim; Rønningen, Ole Petter

    2016-01-01

    We analyze noise properties of time series of frequency data from different counting modes of a Keysight 53230A frequency counter. We use a 10 MHz reference signal from a passive hydrogen maser connected via phase-stable Huber+Suhner Sucoflex 104 cables to the reference and input connectors of the counter. We find that the high resolution gap-free (CONT) frequency counting process imposes long-term correlations in the output data, resulting in a modified Allan deviation that is characteristic of random walk phase noise. Equally important, the CONT mode results in a frequency bias. In contrast, the counter's undocumented raw continuous mode (RCON) yields unbiased frequency stability estimates with white phase noise characteristics, and of a magnitude consistent with the counter's 20 ps single-shot resolution. Furthermore, we demonstrate that a 100-point running average filter in conjunction with the RCON mode yields resolution enhanced frequency estimates with flicker phase noise characteristics. For instance,...

  1. Oxidative stress at high altitude: genotype–phenotype correlations

    Directory of Open Access Journals (Sweden)

    Pandey P

    2014-05-01

    Full Text Available Priyanka Pandey,1,2 MA Qadar Pasha1,2 1CSIR-Institute of Genomics and Integrative Biology, Delhi, India; 2Department of Biotechnology, University of Pune, Ganeshkhind, Pune, India Abstract: It has been well-documented that the hypobaric hypoxic environment at high altitude (HA causes stress to both the permanent residents of HA and the sojourners. This oxidative stress primarily disturbs the oxygen-sensing and vascular homeostasis pathways, thereby upsetting normal human physiology, especially in sojourners. These environmental challenges have caused dynamic evolutionary changes within natives of HA, allowing them to develop adaptive plasticity. This review focuses on the genomic and biochemical features of the molecules involved in the oxygen-sensing and vascular homeostasis pathways with respect to HA pulmonary edema (HAPE and adaptation. We review the role of genetic markers such as HIF-prolyl hydroxylase 2, endothelial PAS domain-containing protein 1, endothelial nitric oxide synthase, endothelin 1, cytochrome b-245 alpha polypeptide, and glutathione S-transferase pi 1, as well as three circulatory biomarkers (nitric oxide, endothelin 1, and 8-iso-prostaglandin F2α, by highlighting approaches such as candidate gene and genome-wide, adopted in deciphering the pathways. A disagreement between the two approaches has also been highlighted. In addition, we discuss that an overrepresentation of wild-type alleles in HA natives and mutant alleles of same polymorphisms in HAPE patients implies that the allelic variants at the same locus are involved in adaptation and HAPE, respectively. Moreover, healthy sojourners present a number of genomic features similar to HA natives, further strengthening the concept of genetic predisposition. A trend in correlation between protective and risk alleles and altered levels of circulatory markers clearly documents the phenomenon of genotype–phenotype correlations. We conclude that the genetic and biochemical

  2. On Neyman-Pearson Theory: Information Content of an Experiment and a Fancy Paradox

    Directory of Open Access Journals (Sweden)

    Benito Vittorio Frosini

    2007-10-01

    Full Text Available Two topics, connected with Neyman-Pearson theory of testing hypotheses, are treated in this article. The first topic is related to the information content of an experiment; after a short outline of ordinal comparability of experiments, the two most popular information measures – by Fisher and by Kullback-Leibler – are considered. As far as we require a comparison of two experiments at a time, the superiority of the couple (a,b of the two error probabilities in the Neyman-Pearson approach is easily established, owing to their clear operational meaning. The second topic deals with the so called Jeffreys – or Lindley – paradox: it can be shown that, if we attach a positive probability to a point null hypothesis, some «paradoxical» posterior probabilities – in a Bayesian approach – result in sharp contrast with the error probabilities in the Neyman-Pearson approach. It is argued that such results are simply the outcomes of absurd assumptions, and it is shown that sensible assumptions about interval – not point – hypotheses can yield posterior probabilities perfectly compatible with the Neyman-Pearson approach (although one must be very careful in making such comparisons, as the two approaches are radically different both in assumptions and in purposes.

  3. Fusarium Osteomyelitis in a Patient With Pearson Syndrome: Case Report and Review of the Literature

    Science.gov (United States)

    Hiebert, Rachael M.; Welliver, Robert C.; Yu, Zhongxin

    2016-01-01

    Fusarium species are ubiquitous fungi causing a wide array of infections, including invasive disease in the immunosuppressed. We present a fusarium bone infection in a child with Pearson syndrome and review the literature. Ten cases of fusarium osteomyelitis were reported in the past 40 years, and we review the treatments. PMID:27757410

  4. Racial Harmony & Heroes: A Content Analysis of the Pearson Reading Program "Good Habits, Great Readers"

    Science.gov (United States)

    Tosolt, Brandelyn; Love, Bettina L.

    2011-01-01

    Multicultural education is a term with a variety of definitions growing from a number of different disciplines. These authors conducted a content analysis of the Pearson reading program "Good Habits, Great Readers" for grades four and five. The qualitative approach of content analysis allowed researchers to examine text "through the…

  5. 多传感器分布式Neyman-Pearson检测%MULTISENSOR DISTRIBUTED NEYMAN-PEARSON DECISION

    Institute of Scientific and Technical Information of China (English)

    甘宇; 朱允民

    2001-01-01

    The authors consider multisensor distributed Neyman-Pearson decision with correlated sensor observation data and suggest an efficient algorithm to search for optimum local compression rules for any fixed fusion rule. The results are supported by computer simulations.%作者讨论了在相关观测下,固定融合律的多传感器分布式二元Neyman-Pearson检测.给出了最优分站压缩律的不动点类的必要条件和相应的离散迭代算法,讨论了算法的收敛性.最后,用计算机数值模拟数据,比较了在各种固定融合律下,分布式Neyman-Pearson检测的性能.

  6. Betaine Chloride-Betaine Tetrachloridoferrate(III—An Ionic Liquid Related Crystal Structure Governed by the Pearson Concept

    Directory of Open Access Journals (Sweden)

    Anja-Verena Mudring

    2012-03-01

    Full Text Available The first betaine chloride tetrachloroidoferrate(III  double salt, (Hbet2Cl[FeCl4] = (HbetCl·(Hbet[FeCl4], was obtained from a solution of betaine hydrochloride (HbetCl and FeCl3∙6 H2O in water. The crystal structure (orthorhombic, Pbcm, a = 6.2717(13, b = 12.841(3, c = 25.693(5 Å, Z = 4 is characterized by layers of tetrachloridoferrate(III anions separated by chloride-bridged, H-bond mediated cationic (Hbet dimers. The hydrogen bonding network in the crystal structure follows the Pearson HSAB (hard acid-soft base concept: According to the Pearson concept, the chloride anions show high affinity to the carboxyl group (hard acid and base, and the tetrachloroidoferrate(III anion preferentially interacts with the activated methyl donors (soft acid and base. These interactions between the COOH group, as hard H-bond donor, and chloride as hard acceptor besides those between the soft, activated methyl groups and the soft tetrachloridoferrate(III anions are the major structure-directing forces in the crystal structure of (Hbet2Cl[FeCl4].

  7. Covariance fitting of highly-correlated data in lattice QCD

    Science.gov (United States)

    Yoon, Boram; Jang, Yong-Chull; Jung, Chulwoo; Lee, Weonjong

    2013-07-01

    We address a frequently-asked question on the covariance fitting of highly-correlated data such as our B K data based on the SU(2) staggered chiral perturbation theory. Basically, the essence of the problem is that we do not have a fitting function accurate enough to fit extremely precise data. When eigenvalues of the covariance matrix are small, even a tiny error in the fitting function yields a large chi-square value and spoils the fitting procedure. We have applied a number of prescriptions available in the market, such as the cut-off method, modified covariance matrix method, and Bayesian method. We also propose a brand new method, the eigenmode shift (ES) method, which allows a full covariance fitting without modifying the covariance matrix at all. We provide a pedagogical example of data analysis in which the cut-off method manifestly fails in fitting, but the rest work well. In our case of the B K fitting, the diagonal approximation, the cut-off method, the ES method, and the Bayesian method work reasonably well in an engineering sense. However, interpreting the meaning of χ 2 is easier in the case of the ES method and the Bayesian method in a theoretical sense aesthetically. Hence, the ES method can be a useful alternative optional tool to check the systematic error caused by the covariance fitting procedure.

  8. Absorption and loss of iron in toddlers are highly correlated.

    Science.gov (United States)

    Fomon, Samuel J; Nelson, Steven E; Serfass, Robert E; Ziegler, Ekhard E

    2005-04-01

    For estimating the requirements for dietary iron, it is important to know the amount of iron that is lost from the body. Inevitable losses of iron have been determined in adult humans but not in infants or children. We administered (58)Fe, the least abundant stable isotope of iron, to free-living infants at 168 d of age (5.6 mo) and followed them to age 26 mo. There was no dietary restriction after isotope administration. Blood was obtained at regular intervals for determination of isotopic enrichment and indices of iron status. We estimated the quantity of circulating iron, noncirculating active iron, and storage iron at each age. The administered isotope equilibrated with total body iron by 13 mo of age. From 13 to 26 mo of age, we estimated inevitable loss and absorption of iron from the change in tracer abundance in circulating iron. The rate of decrease of tracer abundance was proportional to addition of tracee, i.e., absorption of iron. Conversely, the rate of decrease in quantity of tracer was proportional to removal of tracee, i.e., loss of iron. From 13 to 26 mo of age, iron absorption was (mean +/- SD) 0.49 +/- 0.13 mg/d and inevitable iron loss was 0.25 +/- 0.12 mg/d. Intersubject variability of iron loss and iron absorption was high, and iron loss and absorption were highly correlated (r = 0.789, P absorption from the diet was inadequate to maintain or increase iron nutritional status. The data suggest that, in this cohort, which may be representative, the intake of bioavailable iron from 13 to 26 mo of age was insufficient to maintain iron nutritional status.

  9. Shot Range and High Order Correlations in Proteins

    CERN Document Server

    Long, Shiyang

    2016-01-01

    The main chain dihedral angles play an important role to decide the protein conformation. The native states of a protein can be regard as an ensemble of a lot of similar conformations, in different conformations the main chain dihedral angles vary in a certain range. Each dihedral angle value can be described as a distribution, but only using the distribution can't describe the real conformation space. The reason is that the dihedral angle has correlation with others, especially the neighbor dihedral angles in primary sequence. In our study we analysis extensive molecular dynamics (MD) simulation trajectories of eleven proteins with different sizes and folds, we found that in stable second structure the correlations only exist between the dihedrals near to each other in primary sequence, long range correlations are rare. But in unstable structures (loop) long range correlations exist. Further we observed some characteristics of the short range correlations in different second structures ({\\alpha}-helix, {\\bet...

  10. mtDNA Deletion in an Iranian Infant with Pearson Marrow Syndrome

    Directory of Open Access Journals (Sweden)

    Massoud Houshmand

    2010-03-01

    Full Text Available Background:Pearson syndrome (PS is a rare multisystem mitochondrial disorder of hematopoietic system, characterized by refractory sideroblastic anemia, pancytopenia, exocrine pancreatic insufficiency, and variable neurologic, hepatic, renal, and endocrine failure. Case Presentation:We describe a six-month-old female infant with Pearson marrow syndrome who presented with neurological manifestations. She had several episodes of seizures. Hematopoietic abnormalities were macrocytic anemia and neutropenia. Bone marrow aspiration revealed a cellular marrow with marked vacuolization of erythroid and myeloid precursors. Analysis of mtDNA in peripheral blood showed 8.5 kb deletion that was compatible with the diagnosis of PS. Conclusion:PS should be considered in infants with neurologic diseases, in patients with cytopenias, and also in patients with acidosis or refractory anemia.

  11. Global-in-time solutions for the isothermal Matovich-Pearson equations

    CERN Document Server

    Feireisl, Eduard; Mikelic, Andro

    2010-01-01

    In this paper we study the Matovich-Pearson equations describing the process of glass fiber drawing. These equations may be viewed as a 1D-reduction of the incompressible Navier-Stokes equations including free boundary, valid for the drawing of a long and thin glass fiber. We concentrate on the isothermal case without surface tension. Then the Matovich-Pearson equations represent a nonlinearly coupled system of an elliptic equation for the axial velocity and a hyperbolic transport equation for the fluid cross-sectional area. We first prove existence of a local solution, and, after constructing appropriate barrier functions, we deduce that the fluid radius is always strictly positive and that the local solution remains in the same regularity class. To the best of our knowledge, this is the first global existence and uniqueness result for this important system of equations.

  12. A Robust Skin Colour Segmentation Using Bivariate Pearson Type IIαα (Bivariate Beta) Mixture Model

    OpenAIRE

    B.N.Jagadesh; Srinivasa Rao, K.; Ch.Satyanarayana

    2012-01-01

    Probability distributions formulate the basic framework for developing several segmentation algorithms. Among the various segmentation algorithms, skin colour segmentation is one of the most important algorithms for human computer interaction. Due to various random factors influencing the colour space, there does not exist a unique algorithm which serve the purpose of all images. In this paper a novel and new skin colour segmentation algorithms is proposed based on bivariate Pearson type I...

  13. Differentiating the Cochran-Armitage Trend Test and Pearson's χ(2) Test: Location and Dispersion.

    Science.gov (United States)

    Zhou, Zhengyang; Ku, Hung-Chih; Huang, Zhipeng; Xing, Guan; Xing, Chao

    2017-09-01

    In genetic case-control association studies, a standard practice is to perform the Cochran-Armitage (CA) trend test with 1 degree-of-freedom (d.f.) under the assumption of an additive model. However, when the true genetic model is recessive or near recessive, it is outperformed by Pearson's χ(2) test with 2 d.f. In this article, we analytically reveal the statistical basis that leads to the phenomenon. First, we show that the CA trend test examines the location shift between the case and control groups, whereas Pearson's χ(2) test examines both the location and dispersion shifts between the two groups. Second, we show that under the additive model, the effect of location deviation outweighs that of the dispersion deviation and vice versa under a near recessive model. Therefore, Pearson's χ(2) test is a more robust test than the CA trend test, and it outperforms the latter when the mode of inheritance evolves to the recessive end. © 2017 John Wiley & Sons Ltd/University College London.

  14. Testing the Correlation of Ultra-High Energy Cosmic Rays with High Redshift Sources

    CERN Document Server

    Sigl, G; Anchordoqui, L A; Romero, G; Sigl, Guenter; Torres, Diego; Anchordoqui, Luis; Romero, Gustavo

    2001-01-01

    We study the correlation between compact radio quasars and ultra-high energy cosmic rays using an updated list of air shower detections. We estimate the level of positional correlation between both samples and the probability of pure chance association through simulations of random sets of synthetic cosmic ray events. We find that there are no reasons to claim for a physical association and that some previous results appear to be an effect of the small size of the sample used. This is also true when, instead of compact radio quasars, 3EG gamma-ray blazars are considered. Consequently, unless somehow severely deflected, it is unlikely that the high energy CR primaries are new particles or particles with new interactions beyond the electroweak scale, produced in high-redshift active galactic nuclei.

  15. Gluon transverse momentum dependent correlators in polarized high energy processes

    CERN Document Server

    Boer, Daniel; van Daal, Tom; Mulders, Piet J; Signori, Andrea; Zhou, Yajin

    2016-01-01

    We investigate the gluon transverse momentum dependent correlators as Fourier transform of matrix elements of nonlocal operator combinations. At the operator level these correlators include both field strength operators and gauge links bridging the nonlocality. In contrast to the collinear PDFs, the gauge links are no longer unique for transverse momentum dependent PDFs (TMDs) and also Wilson loops lead to nontrivial effects. We look at gluon TMDs for unpolarized, vector and tensor polarized targets. In particular a single Wilson loop operators become important when one considers the small-x limit of gluon TMDs.

  16. Discovering Structure in High-Dimensional Data Through Correlation Explanation

    Science.gov (United States)

    2014-12-08

    using mutual information. EPL ( Europhysics Letters ), 70(2):278, 2005. [6] J. Pearl. Causality: Models, Reasoning and Inference. Cambridge University...information and con- nected correlations. Physical Review Letters , 91(23):238701, 2003. [18] Nihat Ay, Eckehard Olbrich, Nils Bertschinger, and Jürgen Jost. A

  17. Significance Testing Needs a Taxonomy: Or How the Fisher, Neyman-Pearson Controversy Resulted in the Inferential Tail Wagging the Measurement Dog.

    Science.gov (United States)

    Bradley, Michael T; Brand, Andrew

    2016-10-01

    Accurate measurement and a cutoff probability with inferential statistics are not wholly compatible. Fisher understood this when he developed the F test to deal with measurement variability and to make judgments on manipulations that may be worth further study. Neyman and Pearson focused on modeled distributions whose parameters were highly determined and concluded that inferential judgments following an F test could be made with accuracy because the distribution parameters were determined. Neyman and Pearson's approach in the application of statistical analyses using alpha and beta error rates has played a dominant role guiding inferential judgments, appropriately in highly determined situations and inappropriately in scientific exploration. Fisher tried to explain the different situations, but, in part due to some obscure wording, generated a long standing dispute that currently has left the importance of Fisher's p < .05 criteria not fully understood and a general endorsement of the Neyman and Pearson error rate approach. Problems were compounded with power calculations based on effect sizes following significant results entering into exploratory science. To understand in a practical sense when each approach should be used, a dimension reflecting varying levels of certainty or knowledge of population distributions is presented. The dimension provides a taxonomy of statistical situations and appropriate approaches by delineating four zones that represent how well the underlying population of interest is defined ranging from exploratory situations to highly determined populations. © The Author(s) 2016.

  18. Multi-particle correlation observables in high energy nucleus-nucleus collisions

    Energy Technology Data Exchange (ETDEWEB)

    Stock, R.

    1981-01-01

    Global features of exclusively measured events, including number correlations and vector correlations, and hybrid analysis of measurements of one or two specific fragments like spectator nuclei, high transverse momentum particles, polarization of one particle, etc., are considered. (GHT)

  19. Neyman-Pearson Detection of a Gaussian Source using Dumb Wireless Sensors

    CERN Document Server

    Bianchi, Pascal; Roueff, Francois

    2010-01-01

    We investigate the performance of the Neyman-Pearson detection of a stationary Gaussian process in noise, using a large wireless sensor network (WSN). In our model, each sensor compresses its observation sequence using a linear precoder. The final decision is taken by a fusion center (FC) based on the compressed information. Two families of precoders are studied: random iid precoders and orthogonal precoders. We analyse their performance in the regime where both the number of sensors k and the number of samples n per sensor tend to infinity at the same rate, that is, k/n tends to c in (0, 1). Contributions are as follows. 1) Using results of random matrix theory and on large Toeplitz matrices, it is proved that the miss probability of the Neyman-Pearson detector converges exponentially to zero, when the above families of precoders are used. Closed form expressions of the corresponding error exponents are provided. 2) In particular, we propose a practical orthogonal precoding strategy, the Principal Frequencie...

  20. High-pT hadron production and triggered particle correlations

    NARCIS (Netherlands)

    Mischke, A.

    2006-01-01

    The STAR experiment at the Relativistic Heavy-Ion Collider has performed measurements of high transverse momentum particle production in ultra-relativistic heavy-ion collisions. High-pT hadrons are generated from hard parton scatterings early in the collision. The outgoing partons probe the surround

  1. Azimuthal angular correlations in high transverse momentum dijet events

    CERN Document Server

    CMS Collaboration

    2017-01-01

    The azimuthal angle correlation between the two jets with the largest transverse momenta in inclusive 2-jet topologies, close to the back-to-back configuration, is measured for several regions of the leading jet transverse momentum. Measurements of the same observable requiring the presence of extra jets are also presented. The analysis is based on proton-proton collision data collected with the CMS experiment at a center-of-mass energy of $13~\\mathrm{TeV}$ corresponding to an integrated luminosity of $35.9~\\mathrm{fb}^{-1}$. The results are compared to predictions using Monte Carlo event generators which combine perturbative QCD calculations up to next-to-leading-order accuracy with contributions from parton showers, hadronization, and multiparton interactions.

  2. High Tc superconductivity mechanism controlled by electric dipole correlation and charge correlation

    OpenAIRE

    2008-01-01

    The model is based on a mirror symmetry breaking second order phase transition leading to a pairing between a free charge carriers and a free mirror charge carriers. This approach gives a unified description of low and high Tc superconductivity with a point of view differing from that of BCS theory.The material's crystal structure symmetry is the key to understand the mechanism of pairing by introducing a mirror plane polarization effect in lattice as it is described below.

  3. Functional connectivity and structural covariance between regions of interest can be measured more accurately using multivariate distance correlation.

    Science.gov (United States)

    Geerligs, Linda; Cam-Can; Henson, Richard N

    2016-07-15

    Studies of brain-wide functional connectivity or structural covariance typically use measures like the Pearson correlation coefficient, applied to data that have been averaged across voxels within regions of interest (ROIs). However, averaging across voxels may result in biased connectivity estimates when there is inhomogeneity within those ROIs, e.g., sub-regions that exhibit different patterns of functional connectivity or structural covariance. Here, we propose a new measure based on "distance correlation"; a test of multivariate dependence of high dimensional vectors, which allows for both linear and non-linear dependencies. We used simulations to show how distance correlation out-performs Pearson correlation in the face of inhomogeneous ROIs. To evaluate this new measure on real data, we use resting-state fMRI scans and T1 structural scans from 2 sessions on each of 214 participants from the Cambridge Centre for Ageing & Neuroscience (Cam-CAN) project. Pearson correlation and distance correlation showed similar average connectivity patterns, for both functional connectivity and structural covariance. Nevertheless, distance correlation was shown to be 1) more reliable across sessions, 2) more similar across participants, and 3) more robust to different sets of ROIs. Moreover, we found that the similarity between functional connectivity and structural covariance estimates was higher for distance correlation compared to Pearson correlation. We also explored the relative effects of different preprocessing options and motion artefacts on functional connectivity. Because distance correlation is easy to implement and fast to compute, it is a promising alternative to Pearson correlations for investigating ROI-based brain-wide connectivity patterns, for functional as well as structural data.

  4. Charge and spin correlations in high temperature superconductors

    Science.gov (United States)

    Hayden, Stephen

    2013-03-01

    The cuprate high temperatures superconductors are characterised by numerous competing, and in some cases, co-existing broken symmetries. A important question is to what extent such additional ordered states exist for compositions with high superconducting transition temperatures. I will discuss high-energy X-ray diffraction measurements which show that a charge density wave state (CDW) develops at zero field in the normal state of superconducting YBa2Cu3O6.67 (Tc = 67 K). This material has a hole doping of 0.12 per copper and a well-ordered oxygen chain superstructure. Below Tc, the application of a magnetic field suppresses superconductivity and enhances the CDW. We find that the CDW and superconductivity are competing orders with similar energy scales, and the high-Tc superconductivity forms from a pre-existing CDW environment. Our results provide a mechanism for the formation of small Fermi surface pockets which can explain the negative Hall and Seebeck effects and the Tc plateau in this material. Work performed in collaboration with J. Chang, E. Blackburn, A. T. Holmes, N. B. Christensen, J. Larsen, J. Mesot, Ruixing Liang, D. A. Bonn, W. N. Hardy, A. Watenphul, M. v. Zimmermann and E. M. Forgan.

  5. Correlated Terahertz and High Harmonic Generation from Aligned Nitrogen Molecules

    Science.gov (United States)

    Huang, Yindong; Meng, Chao; Wang, Xiaowei; Lv, Zhihui; Zhang, Dongwen; Chen, Wenbo; Zhao, Jing; Yuan, Jianmin; Zhao, Zengxiu

    2016-05-01

    When laser beams are focused on atoms and molecules, wide spectral range of photons can be radiated from the source. In the region of high energy, high harmonic generation (HHG), covering tens to hundreds electron volts, emit within the attosecond timescale. In the low energy region, terahertz wave generation (TWG) can also be generated. Synchronizing TWG with HHG is to take snapshot of the electronic dynamics with time-scale spanning over 6 orders of magnitudes. In this abstract, we report the joint measurements on TWG and HHG from pre-aligned molecules. By calibrating the angular ionization rates with the alignment dependent TWG, we reconstruct the photoionization cross section (PICS) of nitrogen in one run of experiment. The measured PICS is found to be consistent with theoretical predications, although some discrepancies exist. This all-optical method provides a new alternative for investigating molecular structures (Yindong Huang et al., Phys. Rev. Lett. 115, 123002, 2015).

  6. [A regenerative anemia in infants: 2 cases of Pearson´s syndrome].

    Science.gov (United States)

    Martínez de Zabarte Fernández, José M; Rodríguez-Vigil Iturrate, Carmen; Martínez Faci, Cristina; García Jiménez, Inmaculada; Murillo Sanjuan, Laura; Muñoz Mellado, Ascensión

    2017-02-01

    Anemia is very common in infants. Although its causes are usually not severe and treatable, proper etiologic diagnosis should be established. When anemia is non-regenerative, it can be caused by aplastic anemia, myelodysplastic syndrome, bone marrow infiltration or hematopoietic factors deficiencies. Another possible cause is Pearson's syndrome, a rare mitochondrial disease that causes non-regenerative anemia associated with other cytopenias, pancreatic insufficiency, lactic acidosis and great variability in clinical presentation conditioned by heteroplasmy. It is characteristic to find in bone marrow studies variable vacuolization in erythroblastic progenitors and ring sideroblasts. The diagnosis is established by genetic study of mitochondrial deoxyribonucleic acid performed by Southern blot analysis (complete mitochondrial deoxyribonucleic acid amplification by polymerase chain reaction -long), obtaining 70-80% deletion of 4977 bp (NMD 8343-13459). There is no curative therapy and support treatment is the only available nowadays. Death is frequent in early years of life.

  7. Statistical analysis of latent generalized correlation matrix estimation in transelliptical distribution.

    Science.gov (United States)

    Han, Fang; Liu, Han

    2017-02-01

    Correlation matrix plays a key role in many multivariate methods (e.g., graphical model estimation and factor analysis). The current state-of-the-art in estimating large correlation matrices focuses on the use of Pearson's sample correlation matrix. Although Pearson's sample correlation matrix enjoys various good properties under Gaussian models, its not an effective estimator when facing heavy-tail distributions with possible outliers. As a robust alternative, Han and Liu (2013b) advocated the use of a transformed version of the Kendall's tau sample correlation matrix in estimating high dimensional latent generalized correlation matrix under the transelliptical distribution family (or elliptical copula). The transelliptical family assumes that after unspecified marginal monotone transformations, the data follow an elliptical distribution. In this paper, we study the theoretical properties of the Kendall's tau sample correlation matrix and its transformed version proposed in Han and Liu (2013b) for estimating the population Kendall's tau correlation matrix and the latent Pearson's correlation matrix under both spectral and restricted spectral norms. With regard to the spectral norm, we highlight the role of "effective rank" in quantifying the rate of convergence. With regard to the restricted spectral norm, we for the first time present a "sign subgaussian condition" which is sufficient to guarantee that the rank-based correlation matrix estimator attains the optimal rate of convergence. In both cases, we do not need any moment condition.

  8. IDENTIFICATION OF THE MASS DISTRIBUTIONS OF THE MILK FAT PHASE USING UNIVERSAL PEARSON DISTRIBUTIONS

    Directory of Open Access Journals (Sweden)

    A. A. Khvostov

    2015-01-01

    Full Text Available In this paper we consider the problem of approximating the experimental values of the coefficient of attenuation of ultrasonic oscillations and the mass distribution of the fat globules in the milk and milk products. The analysis of experimental data in terms of the choice of the method of approximation was done. A approximating dependence is based on the solution of Pearson differential equations. The advantages of the proposed method for the type of approximation of the experimental data obtained. An algorithm for constructing a mathematical model describing the relaxation spectrum and mass distribution of the fat globules in the milk and milk products was implemented. As a result, a family of Pearson approximation curves of the experimental data shows the ability to qualitatively correctly describe the change in the distribution of the fat phase in the process of homogenization. It estimates the error of approximating dependence, which amounted to 18 %. It is shown that during of the process of homogenization of dairy products changes shape of the curve describing the distribution of the fat globules, in view of the fact that there is a local extremum, caused by the presence of the non-homogenized fat globules. The accuracy of the selected mathematical model is significantly reduced. At the same time, it loses its physical meaning and its parameters. To address the identified deviations in the proposed mass distribution of fat globules as a function with two modes. It is proved that the complexity of the model is not only doubles the number of its parameters, but also complicates the interpretation of measurement results in a control system, and makes it difficult to analyze the obtained parameters of approximation by decision-maker. As a result of approximation of experimental data suggested to use statistical moments of the distribution for problem decision.

  9. High-resolution x-ray scattering studies of charge ordering in highly correlated electron systems

    CERN Document Server

    Ghazi, M E

    2002-01-01

    addition, another very weak satellites with wavevector (1/2, 1, 1/2) were observed possibly due to spin ordering. two-dimensional in nature both by measurements of their correlation lengths and by measurement of the critical exponents of the charge stripe melting transition with an anomaly at x = 0.25. The results show by decreasing the hole concentration from the x = 0.33 to 0.2, the well-correlated charge stripes change to a glassy state at x = 0.25. The electronic transition into the charge stripe phase is second-order without any corresponding structural transition. Above the second-order transition critical scattering was observed due to fluctuations into the charge stripe phase. In a single-crystal of Nd sub 1 sub / sub 2 Sr sub 1 sub / sub 2 MnO sub 3 a series of phase transitions were observed using high-resolution synchrotron X-ray scattering. Above the charge ordering transition temperature, T sub C sub O , by measuring the peak profiles of Bragg reflections as a function of temperature, it was foun...

  10. GHz measurements of correlated electron systems in high magnetic fields

    CERN Document Server

    Edwards, R S

    2002-01-01

    This Thesis presents experiments performed on the high-frequency conductivity of materials in high magnetic fields. The angle dependence of resonances measured in the millimetre-wave absorption is studied using a rotating resonant cavity system, and the frequency dependence is measured using transmission techniques and a tuneable resonant cavity. Chapter 1 introduces the materials. These include the crystalline organic metals, the layered superconductor Sr sub 2 RUO sub 4 and the quantum Ising ferromagnet LiHoF sub 4. In Chapters 2 and 3, the necessary physics and experimental techniques for their investigation are outlined. Chapters 4 to 6 present measurements of cyclotron resonance in layered materials. Chapter 4 describes several models for the origin of cyclotron resonance harmonics, and describes the first definite measurement of the harmonics of a cyclotron resonance in an organic molecular metal, namely beta sup - (BEDT-TTF) sub 2 SF sub 5 CH sub 2 CF sub 2 SO sub 3. The angle dependence of the field p...

  11. Stealing among High School Students: Prevalence and Clinical Correlates

    Science.gov (United States)

    Grant, Jon E.; Potenza, Marc N.; Krishnan-Sarin, Suchitra; Cavallo, Dana A.; Desai, Rani A.

    2013-01-01

    Although stealing among adolescents appears to be fairly common, an assessment of adolescent stealing and its relationship to other behaviors and health issues is incompletely understood. A large sample of high school students (n=3999) was examined using a self-report survey with 153 questions concerning demographic characteristics, stealing behaviors, other health behaviors including substance use, and functioning variables such as grades and violent behavior. The overall prevalence of stealing was 15.2% (95%CI: 14.8–17.0). Twenty-nine (0.72%) students endorsed symptoms consistent with a diagnosis of DSM-IV kleptomania. Poor grades, alcohol and drug use, regular smoking, sadness and hopelessness, and other antisocial behaviors were all significantly (p<.05) associated with any stealing behavior. Stealing appears fairly common among high school students and is associated with a range of potentially addictive and antisocial behaviors. Significant distress and loss of control over this behavior suggests that stealing often has significant associated morbidity. PMID:21389165

  12. Heat-transfer correlations for high-finned tubes in staggered arrangements

    Energy Technology Data Exchange (ETDEWEB)

    Hashizume, Kenichi [Hiroshima Inst. of Tech. (Japan). Dept. of Mechanical Engineering

    1995-12-31

    Existing correlations are reviewed for heat transfer of high-finned tubes in staggered arrangements and compared with published experimental data. These data include those using tubes for air-coolers (AC) and for heat-recovery heat exchangers in the high-temperature region (HRHX). Comparisons showed that none of the correlations can predict experimental data for both AC and for HRHX. Therefore a new correlation is proposed which can predict almost all data within 10 percent.

  13. Coarsening kinetics of topologically highly correlated grain boundary networks

    Science.gov (United States)

    Tang, Ming; Reed, Bryan W.; Kumar, Mukul

    2012-08-01

    We apply phase-field simulations in two dimensions to study the thermal coarsening of grain boundary (GB) networks with high fractions of twin and twin-variant boundaries, which for example are seen in grain-boundary-engineered FCC materials. Two types of grain boundary networks with similar starting special boundary fractions but different topological features were considered as initial conditions for the grain growth simulations. A lattice Monte Carlo method creates polycrystalline microstructures (Reed and Kumar (RK)), which exhibit hierarchical organization of random and special coincidence site lattice boundaries. The other type of microstructures (randomly distributed (RD)) contains random distributions of special boundaries subject only to crystallographic constraints. Under the assumption that random boundaries have larger energy and much higher mobility than special boundaries, simulations show that increasing the initial special boundary fraction in both microstructures slows down grain growth. However, the two starting microstructures exhibit very different behavior in the evolution of GB character and triple junction (TJ) distributions. The RD networks coarsened more slowly than the RK networks with comparable initial fractions of special boundaries. The observed trend in the evolution of the RK microstructures is explained by an extended von Neumann-Mullins analysis. This study demonstrates that the special boundary fraction is not a sufficient indicator of the coarsening behavior of twinned GB networks; the network topology must also be considered to correctly predict the grain growth kinetics.

  14. Evaluation of Fatigue Life Reliability of Steering Knuckle Using Pearson Parametric Distribution Model

    Directory of Open Access Journals (Sweden)

    E. A. Azrulhisham

    2010-01-01

    Full Text Available Steering module is a part of automotive suspension system which provides a means for an accurate vehicle placement and stability control. Components such as steering knuckle are subjected to fatigue failures due to cyclic loads arising from various driving conditions. This paper intends to give a description of a method used in the fatigue life reliability evaluation of the knuckle used in a passenger car steering system. An accurate representation of Belgian pave service loads in terms of response-time history signal was obtained from accredited test track using road load data acquisition. The acquired service load data was replicated on durability test rig and the SN method was used to estimate the fatigue life. A Pearson system was developed to evaluate the predicted fatigue life reliability by considering the variations in material properties. Considering random loads experiences by the steering knuckle, it is found that shortest life appears to be in the vertical load direction with the lowest fatigue life reliability between 14000–16000 cycles. Taking into account the inconsistency of the material properties, the proposed method is capable of providing the probability of failure of mass-produced parts.

  15. APLIKASI KORELASI PEARSON DALAM MEMBANGUN MODEL TREE-AUGMENTED NETWORK (TAN (Studi Kasus Pengenalan Karakter Tulisan Tangan

    Directory of Open Access Journals (Sweden)

    Irwan Budi Santoso

    2013-10-01

    Full Text Available Langkah pertama dalam membangun model pengenalan Tree-Augmented Network (TAN  dengan  mengukur  besarnya  hubungan  diantara  pasangan  fitur  objek.  Salah  satu metode yang dapat digunakan mengukur besarnya keeratan hubungan secara linier diantara pasangan fitur adalah   Korelasi Pearson. Aplikasi Korelasi Pearson  dalam membangun model Tree-Augmented Network (TAN dalam penelitian ini, akan diujicobakan pada kasus membangun  model pengenalan karakter tulisan tangan. Data fitur karakter tulisan tangan untuk kasus ini, diasumsikan mengikuti distribusi gaussian karena estimasi parameter model pengenalannya menggunakan estimator Maximum Likelihood (ML. Hasil eksperimen dengan menggunakan data training yang terdiri dari 5 jenis karakter tulisan tangan, menunjukkan untuk dimensi fitur karakter tulisan tangan 10x30 (30 fitur, akurasi sistem Korelasi Pearson dalam membangun model TAN untuk mengenali karakter tulisan tangan  sebesar 88 %.

  16. High-energy photoemission spectroscopy for investigating bulk electronic structures of strongly correlated systems

    Energy Technology Data Exchange (ETDEWEB)

    Sekiyama, Akira, E-mail: sekiyama@mp.es.osaka-u.ac.jp [Division of Materials Physics, Graduate School of Engineering Science, Osaka University, Toyonaka 560-8531, Osaka (Japan); SPring-8/RIKEN, Sayo 679-5148, Hyogo (Japan)

    2016-04-15

    Progress of high-energy photoemission spectroscopy for investigating the bulk electronic structures of strongly correlated electron systems is reviewed. High-resolution soft X-ray photoemission has opened the door for revealing the bulk strongly correlated spectral functions overcoming the surface contributions. More bulk-sensitive hard X-ray photoemission spectroscopy (HAXPES) enables us to study the electronic structure with negligible surface contribution. The recent development of the polarization-dependent HAXPES is also described in this short review.

  17. Renormalization group evolution of multi-gluon correlators in high energy QCD

    Science.gov (United States)

    Dumitru, A.; Jalilian-Marian, J.; Lappi, T.; Schenke, B.; Venugopalan, R.

    2011-12-01

    Many-body QCD in leading high energy Regge asymptotics is described by the Balitsky-JIMWLK hierarchy of renormalization group equations for the x evolution of multi-point Wilson line correlators. These correlators are universal and ubiquitous in final states in deeply inelastic scattering and hadronic collisions. For instance, recently measured di-hadron correlations at forward rapidity in deuteron-gold collisions at the Relativistic Heavy Ion Collider (RHIC) are sensitive to four and six point correlators of Wilson lines in the small x color fields of the dense nuclear target. We evaluate these correlators numerically by solving the functional Langevin equation that describes the Balitsky-JIMWLK hierarchy. We compare the results to mean-field Gaussian and large Nc approximations used in previous phenomenological studies. We comment on the implications of our results for quantitative studies of multi-gluon final states in high energy QCD.

  18. Renormalization group evolution of multi-gluon correlators in high energy QCD

    CERN Document Server

    Dumitru, Adrian; Lappi, Tuomas; Schenke, Bjoern; Venugopalan, Raju

    2011-01-01

    Many-body QCD in leading high energy Regge asymptotics is described by the Balitsky-JIMWLK hierarchy of renormalization group equations for the x evolution of multi-point Wilson line correlators. These correlators are universal and ubiquitous in final states in deeply inelastic scattering and hadronic collisions. For instance, recently measured di-hadron correlations at forward rapidity in deuteron-gold collisions at the Relativistic Heavy Ion Collider (RHIC) are sensitive to four and six point correlators of Wilson lines in the small x color fields of the dense nuclear target. We evaluate these correlators numerically by solving the functional Langevin equation that describes the Balitsky-JIMWLK hierarchy. We compare the results to mean-field Gaussian and large N_c approximations used in previous phenomenological studies. We comment on the implications of our results for quantitative studies of multi-gluon final states in high energy QCD.

  19. New Multivariate Skew t Distributions Generated from Skew Pearson Ⅷ Distributions%从偏态Pearson Ⅶ分布生成的新的多元偏态t分布

    Institute of Scientific and Technical Information of China (English)

    温阳俊; 朱道元

    2009-01-01

    一般而言,偏态的椭球等高分布是一类分布族,有相当一部分的分布都是积分形式,且此类积分不易求出,而偏态的正态、偏态的正态尺度混合、偏态的PⅦ型、偏态的PⅡ型的分布却有着很好的结构,偏态t分布属于偏态PⅦ型分布,因此,本文在偏态PⅦ型分布的基础上着重研究新的偏态t分布,给出它的背景、定义、两种随机表示及其等价性.%In general, there are a large number of skew elliptically contoured distributions with hard calculated integral forms, while skew normal, skew normal scale mixtures, skew Pearson type Ⅷ and skew Pearson type Ⅱ distributions possess good structures. Skew t distributions belong to skew Pearson type Ⅷ distributions, therefore, this paper proposes new multivariate skew t distributions based on multivariate skew Pearson type Ⅷ distributions. Backgrounds and definitions are given, two stochastic representations and their equivalence are derived.

  20. Improving standards in brain-behavior correlation analyses.

    Science.gov (United States)

    Rousselet, Guillaume A; Pernet, Cyril R

    2012-01-01

    Associations between two variables, for instance between brain and behavioral measurements, are often studied using correlations, and in particular Pearson correlation. However, Pearson correlation is not robust: outliers can introduce false correlations or mask existing ones. These problems are exacerbated in brain imaging by a widespread lack of control for multiple comparisons, and several issues with data interpretations. We illustrate these important problems associated with brain-behavior correlations, drawing examples from published articles. We make several propositions to alleviate these problems.

  1. Calibration of ultra high speed laser engraving processes by correlating influencing variables including correlative evaluation with SEM and CLSM

    Science.gov (United States)

    Bohrer, Markus; Vaupel, Matthias; Nirnberger, Robert; Weinberger, Bernhard

    2016-03-01

    Laser engraving is used for decades as a well-established process e. g. for the production of print and embossing forms for many goods in daily life, e. g. decorated cans and printed bank notes. Up to now it is more or less a so-called fire-and-forget process. From the original artist's plan to the digitization, then from the laser source itself (with electronic signals, RF and plasma discharge regarding CO2 lasers) to the behavior of the optical beam delivery — especially if an AOM is used — to the interaction of the laser beam with the material itself is a long process chain. The most recent results using CO2 lasers with AOMs and the research done with scanning electron microscope (SEM) and confocal laser scanning microscope (CLSM) — as a set for correlative microscopy to evaluate the high speed engraving characteristics — are presented in this paper.

  2. The feasibility and application of gray scale adjustment method in high temperature digital image correlation

    Science.gov (United States)

    Wang, Shen; Yao, Xue Feng; Su, Yun Quan; Liu, Wei

    2017-02-01

    In this paper, the basic principle and application of linear gray scale adjustment method are investigated in high temperature digital image correlation (DIC) technology. First, the simple linear gray scale adjustment method is proposed, which can adjust the gray scale value of the saturated pixels and diminish the correlation error caused by the saturated pixels. Then, both the simulated high temperature images and DIC correlation results before and after the gray scale adjustment are provided and analyzed to verify its effectiveness, in which the displacement error decreased from 0.1 pixels to 0.04 pixels after the linear gray scale adjustment for high temperature images. Finally, the linear gray scale adjustment method is used to extract the displacement with high accuracy in high temperature experiment of SiC specimen, and the displacement error decreased from 0.5 pixels to 0.1 pixels after the linear gray scale adjustment.

  3. Bias-corrected Pearson estimating functions for Taylor’s power law applied to benthic macrofauna data

    DEFF Research Database (Denmark)

    Jørgensen, Bent; Demétrio, Clarice G.B.; Kristensen, Erik

    2011-01-01

    Estimation of Taylor’s power law for species abundance data may be performed by linear regression of the log empirical variances on the log means, but this method suffers from a problem of bias for sparse data. We show that the bias may be reduced by using a bias-corrected Pearson estimating...

  4. High Correlated Paternity Leads to Negative Effects on Progeny Performance in Two Mediterranean Shrub Species

    Science.gov (United States)

    Nora, Sofia; Aparicio, Abelardo; Albaladejo, Rafael G.

    2016-01-01

    Anthropogenic habitat deterioration can promote changes in plant mating systems that subsequently may affect progeny performance, thereby conditioning plant recruitment for the next generation. However, very few studies yet tested mating system parameters other than outcrossing rates; and the direct effects of the genetic diversity of the pollen received by maternal plants (i.e. correlated paternity) has often been overlooked. In this study, we investigated the relation between correlated paternity and progeny performance in two common Mediterranean shrubs, Myrtus communis and Pistacia lentiscus. To do so, we collected open-pollinated progeny from selected maternal plants, calculated mating system parameters using microsatellite genotyping and conducted sowing experiments under greenhouse and field conditions. Our results showed that some progeny fitness components were negatively affected by the high correlated paternity of maternal plants. In Myrtus communis, high correlated paternity had a negative effect on the proportion and timing of seedling emergence in the natural field conditions and in the greenhouse sowing experiment, respectively. In Pistacia lentiscus, seedling emergence time under field conditions was also negatively influenced by high correlated paternity and a progeny survival analysis in the field experiment showed greater mortality of seedlings from maternal plants with high correlated paternity. Overall, we found effects of correlated paternity on the progeny performance of Myrtus communis, a self-compatible species. Further, we also detected effects of correlated paternity on the progeny emergence time and survival in Pistacia lentiscus, an obligate outcrossed species. This study represents one of the few existing empirical examples which highlight the influence that correlated paternity may exert on progeny performance in multiple stages during early seedling growth. PMID:27835658

  5. Cross-correlations in high-conductance states of a model cortical network

    DEFF Research Database (Denmark)

    Hertz, John

    2010-01-01

    (dansk abstrakt findes ikke) Neuronal firing correlations are studied using simulations of a simple network model for a cortical column in a high-conductance state with dynamically balanced excitation and inhibition.  Although correlations between individual pairs of neurons exhibit considerable...... heterogeneity, population averages show systematic behavior. When the network is in a stationary state, the average correlations are generically small: correlation coefficients are of order 1/N, where N is the number of neurons in the network. However, when the input to the network varies strongly in time, much...... larger values are found. In this situation, the network is out of balance, and the synaptic conductance is low, at times when the strongest firing occurs.  However, examination of the correlation functions of synaptic currents reveals that after these bursts, balance is restored within a few ms...

  6. Econometric analysis of realized covariation: high frequency based covariance, regression, and correlation in financial economics

    DEFF Research Database (Denmark)

    Barndorff-Nielsen, Ole Eiler; Shephard, N.

    2004-01-01

    This paper analyses multivariate high frequency financial data using realized covariation. We provide a new asymptotic distribution theory for standard methods such as regression, correlation analysis, and covariance. It will be based on a fixed interval of time (e.g., a day or week), allowing...... the number of high frequency returns during this period to go to infinity. Our analysis allows us to study how high frequency correlations, regressions, and covariances change through time. In particular we provide confidence intervals for each of these quantities....

  7. Puzzlingly High Correlations in fMRI Studies of Emotion, Personality, and Social Cognition

    Science.gov (United States)

    Vul, Edward; Harris, Christine; Winkielman, Piotr; Pashler, Harold

    2009-01-01

    Functional Magnetic Resonance Imaging (fMRI) studies of emotion, personality, and social cognition have drawn much attention in recent years, with high-profile studies frequently reporting extremely high (e.g., > 8) correlations between behavioral and self-report measures of personality or emotion and measures of brain activation. We show that…

  8. Matrix correlations for high-dimensional data: The modified RV-coefficient

    NARCIS (Netherlands)

    Smilde, A.K.; Kiers, H.A.L.; Bijlsma, S.; Rubingh, C.M.; Erk, M.J. van

    2009-01-01

    Motivation: Modern functional genomics generates high-dimensional datasets. It is often convenient to have a single simple number characterizing the relationship between pairs of such high-dimensional datasets in a comprehensive way. Matrix correlations are such numbers and are appealing since they

  9. Matrix correlations for high-dimensional data : The modified RV-coefficient

    NARCIS (Netherlands)

    Smilde, A. K.; Kiers, H. A. L.; Bijlsma, S.; Rubingh, C. M.; van Erk, M. J.

    2009-01-01

    Motivation: Modern functional genomics generates high-dimensional datasets. It is often convenient to have a single simple number characterizing the relationship between pairs of such high-dimensional datasets in a comprehensive way. Matrix correlations are such numbers and are appealing since they

  10. Matrix correlations for high-dimensional data: the modified RV-coefficient

    NARCIS (Netherlands)

    Smilde, A.K.; Kiers, H.A.L.; Bijlsma, S.; Rubingh, C.M.; van Erk, M.J.

    2009-01-01

    Motivation: Modern functional genomics generates high-dimensional datasets. It is often convenient to have a single simple number characterizing the relationship between pairs of such high-dimensional datasets in a comprehensive way. Matrix correlations are such numbers and are appealing since they

  11. Correlation among High School Senior Students' Test Anxiety, Academic Performance and Points of University Entrance Exam

    Science.gov (United States)

    Karatas, Hakan; Alci, Bulent; Aydin, Hasan

    2013-01-01

    Test anxiety seems like a benign problem to some people, but it can be potentially serious when it leads to high levels of distress and academic failure. The aim of this study is to define the correlation among high school senior students' test anxiety, academic performance (GPA) and points of university entrance exam (UEE). The study group of…

  12. Correlation among High School Senior Students' Test Anxiety, Academic Performance and Points of University Entrance Exam

    Science.gov (United States)

    Karatas, Hakan; Alci, Bulent; Aydin, Hasan

    2013-01-01

    Test anxiety seems like a benign problem to some people, but it can be potentially serious when it leads to high levels of distress and academic failure. The aim of this study is to define the correlation among high school senior students' test anxiety, academic performance (GPA) and points of university entrance exam (UEE). The study group of…

  13. Correlation Function Approach for Estimating Thermal Conductivity in Highly Porous Fibrous Materials

    Science.gov (United States)

    Martinez-Garcia, Jorge; Braginsky, Leonid; Shklover, Valery; Lawson, John W.

    2011-01-01

    Heat transport in highly porous fiber networks is analyzed via two-point correlation functions. Fibers are assumed to be long and thin to allow a large number of crossing points per fiber. The network is characterized by three parameters: the fiber aspect ratio, the porosity and the anisotropy of the structure. We show that the effective thermal conductivity of the system can be estimated from knowledge of the porosity and the correlation lengths of the correlation functions obtained from a fiber structure image. As an application, the effects of the fiber aspect ratio and the network anisotropy on the thermal conductivity is studied.

  14. H-ATLAS High-Z Sources: An Optimal Sample for Cross-Correlation Analyses

    CERN Document Server

    González-Nuevo, J; Bianchini, F

    2014-01-01

    We report a highly signicant ( > 10 ) spatial correlation between galaxies with S 350 m 30 mJy detected in the equatorial elds of the Herschel Astrophysical Terahertz Large Area Survey (H-ATLAS) with estimated redshifts & 1 : 5, and SDSS or GAMA galaxies at 0 : 2 z 0 : 6. The signicance of the cross-correlation is much higher than those reported so far for samples with non-overlapping redshift distributions selected in other wavebands.

  15. High dynamic range multi-channel cross-correlator for single-shot temporal contrast measurement

    Science.gov (United States)

    Kon, A.; Nishiuchi, M.; Kiriyama, H.; Ogura, K.; Mori, M.; Sakaki, H.; Kando, M.; Kondo, K.

    2016-05-01

    We have developed a multi-channel cross-correlator for high dynamic range (>1010), single-shot temporal contrast measurements. The correlator utilizes a third-order crosscorrelation technique and has a reference channel, to be normalized by the measured peak intensity, and four independent optical delay lines. The measurement results of the shot-to-shot temporal contrast clearly show the intensity fluctuations of short pre-pulses at -4.5 ps and -26 ps before main pulse.

  16. Child abuse potential inventory and parenting behavior: relationships with high-risk correlates.

    Science.gov (United States)

    Haskett, M E; Scott, S S; Fann, K D

    1995-12-01

    The primary purpose of this research was to examine the construct validity of the Child Abuse Potential Inventory by comparing maltreating and high-risk parents' CAP Inventory abuse scores to their behavior during interactions with their children. A second purpose was to determine the degree to which CAP Inventory scores and parenting behavior were related to several known correlates of abuse, as measured by parent and teacher reports. Participants (n = 41) included abusive and high-risk parents and their children referred to a treatment group. Correlational analyses revealed that CAP Inventory scores and observed parenting style yielded highly related findings, supporting construct validity of the CAP Inventory. However, the CAP Inventory and observed behavior index showed a different pattern of relationships to the risk correlates. Implications for assessment of risk status are discussed and recommendations are provided for continued research.

  17. Correlation between high-risk pregnancy and developmental delay in children aged 4–60 months

    Directory of Open Access Journals (Sweden)

    Saba Amiri

    2012-09-01

    Full Text Available Background: The future development of children is considered more than ever now due to the advances in medical knowledge and thus the increase in survival rates of high-risk infants. This study investigated the correlation between high-risk pregnancy and developmental delay in children aged 4–60 months. Methods: This descriptive study was conducted on 401 mothers and their children (4–60 months who visited health service centers affiliated to Isfahan University of Medical Sciences, Iran, in 2011. Sampling was carried out in several stages, and the Ages and Stage Questionnaire was completed by the participants. Data were analyzed with SPSS 18 software and independent t-test; Mann-Whitney and logistic-regression tests were used. Results: The average age of children in the low-risk pregnancy group was 22±16 months, and that in the high-risk pregnancy group was 18.9±14.8 months. The majority of children were female (53.1%. The prevalence of high-risk pregnancies was 80.5%, and the prevalence of developmental delay was 18.7%. Multiple pregnancies, low birth weight, habitual abortions, maternal medical disorders in pregnancy, and gestational diabetes had significant correlations with developmental delay in children (P<0.04. In the logistic model, male gender, low birth weight, family marriage, and maternal medical disorders during pregnancy showed significant correlations with developmental delay in children (P<0.05. Additionally, abnormal body mass index (BMI and social and economic status showed probability values close to the significance level (P = 0.05, whereas other high-risk pregnancy variables had no correlation with developmental delay in children. A correlation between high-risk pregnancy and developmental delay (P = 0.002 and fine motor delay was observed (P = 0.02, but no correlation was observed between high-risk pregnancy and other developmental domains. Conclusion: This study showed that some high-risk pregnancy variables had a

  18. High-precision correlative fluorescence and electron cryo microscopy using two independent alignment markers

    Energy Technology Data Exchange (ETDEWEB)

    Schellenberger, Pascale [Oxford Particle Imaging Centre, Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN (United Kingdom); Kaufmann, Rainer [Oxford Particle Imaging Centre, Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN (United Kingdom); Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU (United Kingdom); Siebert, C. Alistair; Hagen, Christoph [Oxford Particle Imaging Centre, Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN (United Kingdom); Wodrich, Harald [Microbiologie Fondamentale et Pathogénicité, MFP CNRS UMR 5234, University of Bordeaux SEGALEN, 146 rue Leo Seignat, 33076 Bordeaux (France); Grünewald, Kay, E-mail: kay@strubi.ox.ac.uk [Oxford Particle Imaging Centre, Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN (United Kingdom)

    2014-08-01

    Correlative light and electron microscopy (CLEM) is an emerging technique which combines functional information provided by fluorescence microscopy (FM) with the high-resolution structural information of electron microscopy (EM). So far, correlative cryo microscopy of frozen-hydrated samples has not reached better than micrometre range accuracy. Here, a method is presented that enables the correlation between fluorescently tagged proteins and electron cryo tomography (cryoET) data with nanometre range precision. Specifically, thin areas of vitrified whole cells are examined by correlative fluorescence cryo microscopy (cryoFM) and cryoET. Novel aspects of the presented cryoCLEM workflow not only include the implementation of two independent electron dense fluorescent markers to improve the precision of the alignment, but also the ability of obtaining an estimate of the correlation accuracy for each individual object of interest. The correlative workflow from plunge-freezing to cryoET is detailed step-by-step for the example of locating fluorescence-labelled adenovirus particles trafficking inside a cell. - Highlights: • Vitrified mammalian cell were imaged by fluorescence and electron cryo microscopy. • TetraSpeck fluorescence markers were added to correct shifts between cryo fluorescence channels. • FluoSpheres fiducials were used as reference points to assign new coordinates to cryoEM images. • Adenovirus particles were localised with an average correlation precision of 63 nm.

  19. Angular correlation between IceCube high-energy starting events and starburst sources

    CERN Document Server

    Moharana, Reetanjali

    2016-01-01

    Starburst galaxies and star-forming regions in the Milkyway, with high rate of supernova activities, are candidate sources of high-energy neutrinos. Using a gamma-ray selected sample of these sources we perform statistical analysis of their angular correlation with the four-year sample of high-energy starting events (HESE), detected by the IceCube Neutrino Observatory. We find that the two samples (starburst galaxies and local star-forming regions) are correlated with cosmic neutrinos at $\\sim (2-3)\\sigma$ (pre-trial) significance level, when the full HESE sample with deposited energy $\\gtrsim 20$~TeV is considered. However when we consider the HESE sample with deposited energy $\\gtrsim 60$~TeV, which is almost free of atmospheric neutrino and muon backgrounds, the significance of correlation decreased drastically. We perform a similar study for Galactic sources in the 2FHL catalog as well, obtaining $\\sim (2-3)\\sigma$ (pre-trial) correlation, however the significance of correlation increases with higher cuto...

  20. Visualization of biological texture using correlation coefficient images.

    Science.gov (United States)

    Sviridov, Alexander P; Ulissi, Zachary; Chernomordik, Victor; Hassan, Moinuddin; Gandjbakhche, Amir H

    2006-01-01

    Subsurface structural features of biological tissue are visualized using polarized light images. The technique of Pearson correlation coefficient analysis is used to reduce blurring of these features by unpolarized backscattered light and to visualize the regions of high statistical similarities within the noisy tissue images. It is shown that under certain conditions, such correlation coefficient maps are determined by the textural character of tissues and not by the chosen region of interest, providing information on tissue structure. As an example, the subsurface texture of a demineralized tooth sample is enhanced from a noisy polarized light image.

  1. Correlated cryo-fluorescence and cryo-electron microscopy with high spatial precision and improved sensitivity

    Energy Technology Data Exchange (ETDEWEB)

    Schorb, Martin [Structural and Computational Biology Unit, European Molecular Biology Laboratory, D-69117 Heidelberg (Germany); Briggs, John A.G., E-mail: john.briggs@embl.de [Structural and Computational Biology Unit, European Molecular Biology Laboratory, D-69117 Heidelberg (Germany); Cell Biology and Biophysics Unit, European Molecular Biology Laboratory, D-69117 Heidelberg (Germany)

    2014-08-01

    Performing fluorescence microscopy and electron microscopy on the same sample allows fluorescent signals to be used to identify and locate features of interest for subsequent imaging by electron microscopy. To carry out such correlative microscopy on vitrified samples appropriate for structural cryo-electron microscopy it is necessary to perform fluorescence microscopy at liquid-nitrogen temperatures. Here we describe an adaptation of a cryo-light microscopy stage to permit use of high-numerical aperture objectives. This allows high-sensitivity and high-resolution fluorescence microscopy of vitrified samples. We describe and apply a correlative cryo-fluorescence and cryo-electron microscopy workflow together with a fiducial bead-based image correlation procedure. This procedure allows us to locate fluorescent bacteriophages in cryo-electron microscopy images with an accuracy on the order of 50 nm, based on their fluorescent signal. It will allow the user to precisely and unambiguously identify and locate objects and events for subsequent high-resolution structural study, based on fluorescent signals. - Highlights: • Workflow for correlated cryo-fluorescence and cryo-electron microscopy. • Cryo-fluorescence microscopy setup incorporating a high numerical aperture objective. • Fluorescent signals located in cryo-electron micrographs with 50 nm spatial precision.

  2. Genome-scale cluster analysis of replicated microarrays using shrinkage correlation coefficient.

    Science.gov (United States)

    Yao, Jianchao; Chang, Chunqi; Salmi, Mari L; Hung, Yeung Sam; Loraine, Ann; Roux, Stanley J

    2008-06-18

    Currently, clustering with some form of correlation coefficient as the gene similarity metric has become a popular method for profiling genomic data. The Pearson correlation coefficient and the standard deviation (SD)-weighted correlation coefficient are the two most widely-used correlations as the similarity metrics in clustering microarray data. However, these two correlations are not optimal for analyzing replicated microarray data generated by most laboratories. An effective correlation coefficient is needed to provide statistically sufficient analysis of replicated microarray data. In this study, we describe a novel correlation coefficient, shrinkage correlation coefficient (SCC), that fully exploits the similarity between the replicated microarray experimental samples. The methodology considers both the number of replicates and the variance within each experimental group in clustering expression data, and provides a robust statistical estimation of the error of replicated microarray data. The value of SCC is revealed by its comparison with two other correlation coefficients that are currently the most widely-used (Pearson correlation coefficient and SD-weighted correlation coefficient) using statistical measures on both synthetic expression data as well as real gene expression data from Saccharomyces cerevisiae. Two leading clustering methods, hierarchical and k-means clustering were applied for the comparison. The comparison indicated that using SCC achieves better clustering performance. Applying SCC-based hierarchical clustering to the replicated microarray data obtained from germinating spores of the fern Ceratopteris richardii, we discovered two clusters of genes with shared expression patterns during spore germination. Functional analysis suggested that some of the genetic mechanisms that control germination in such diverse plant lineages as mosses and angiosperms are also conserved among ferns. This study shows that SCC is an alternative to the Pearson

  3. Genome-scale cluster analysis of replicated microarrays using shrinkage correlation coefficient

    Directory of Open Access Journals (Sweden)

    Loraine Ann

    2008-06-01

    This study shows that SCC is an alternative to the Pearson correlation coefficient and the SD-weighted correlation coefficient, and is particularly useful for clustering replicated microarray data. This computational approach should be generally useful for proteomic data or other high-throughput analysis methodology.

  4. High plasma triglyceride levels strongly correlate with low kisspeptin in the arcuate nucleus of male rats

    DEFF Research Database (Denmark)

    Overgaard, A; Axel, A M; Lie, M E;

    2015-01-01

    signals to the GnRH neurons. METHODS: In this study, we measured body weight and plasma concentrations of leptin, insulin, testosterone, and triglycerides after high fat diet exposure and correlated these parameters with the number of kisspeptin-immunoreactive neurons in the arcuate nucleus of male rats....... In this model, a high fat diet (45% or 60% energy from fat, respectively) or a control diet (10% energy from fat) was provided after weaning for three months. RESULTS: We find a significant increase in body weight and plasma leptin concentration, but no change in the number of kisspeptin-immunoreactive cells...... with increased fat in the diet. Kisspeptin-immunoreactive cells are not correlated with body weight, testosterone, leptin or insulin. However, we find that the number of kisspeptin-immunoreactive cells is strongly and negatively correlated with the level of plasma triglycerides (R2=0.49, p=0.004). CONCLUSION: We...

  5. CGC/saturation approach for soft interactions at high energy: long range rapidity correlations

    Energy Technology Data Exchange (ETDEWEB)

    Gotsman, E.; Maor, U. [Tel Aviv University, Department of Particle Physics, School of Physics and Astronomy, Raymond and Beverly Sackler Faculty of Exact Science, Tel Aviv (Israel); Levin, E. [Tel Aviv University, Department of Particle Physics, School of Physics and Astronomy, Raymond and Beverly Sackler Faculty of Exact Science, Tel Aviv (Israel); Universidad Tecnica Federico Santa Maria and Centro Cientifico- Tecnologico de Valparaiso, Departemento de Fisica, Valparaiso (Chile)

    2015-11-15

    In this paper we continue our program to construct a model for high energy soft interactions that is based on the CGC/saturation approach. The main result of this paper is that we have discovered a mechanism that leads to large long range rapidity correlations and results in large values of the correlation function R(y{sub 1}, y{sub 2}) ≥ 1, which is independent of y{sub 1} and y{sub 2}. Such a behavior of the correlation function provides strong support for the idea that at high energies the system of partons that is produced is not only dense but also has strong attractive forces acting between the partons. (orig.)

  6. Beyond Correlations: Usefulness of High School GPA and Test Scores in Making College Admissions Decisions

    Science.gov (United States)

    Sawyer, Richard

    2013-01-01

    Correlational evidence suggests that high school GPA is better than admission test scores in predicting first-year college GPA, although test scores have incremental predictive validity. The usefulness of a selection variable in making admission decisions depends in part on its predictive validity, but also on institutions' selectivity and…

  7. Rate-adaptive BCH coding for Slepian-Wolf coding of highly correlated sources

    DEFF Research Database (Denmark)

    Forchhammer, Søren; Salmistraro, Matteo; Larsen, Knud J.

    2012-01-01

    This paper considers using BCH codes for distributed source coding using feedback. The focus is on coding using short block lengths for a binary source, X, having a high correlation between each symbol to be coded and a side information, Y, such that the marginal probability of each symbol, Xi in...

  8. High-precision correlative fluorescence and electron cryo microscopy using two independent alignment markers.

    Science.gov (United States)

    Schellenberger, Pascale; Kaufmann, Rainer; Siebert, C Alistair; Hagen, Christoph; Wodrich, Harald; Grünewald, Kay

    2014-08-01

    Correlative light and electron microscopy (CLEM) is an emerging technique which combines functional information provided by fluorescence microscopy (FM) with the high-resolution structural information of electron microscopy (EM). So far, correlative cryo microscopy of frozen-hydrated samples has not reached better than micrometre range accuracy. Here, a method is presented that enables the correlation between fluorescently tagged proteins and electron cryo tomography (cryoET) data with nanometre range precision. Specifically, thin areas of vitrified whole cells are examined by correlative fluorescence cryo microscopy (cryoFM) and cryoET. Novel aspects of the presented cryoCLEM workflow not only include the implementation of two independent electron dense fluorescent markers to improve the precision of the alignment, but also the ability of obtaining an estimate of the correlation accuracy for each individual object of interest. The correlative workflow from plunge-freezing to cryoET is detailed step-by-step for the example of locating fluorescence-labelled adenovirus particles trafficking inside a cell. © 2013 Published by Elsevier B.V.

  9. Multilabel image classification via high-order label correlation driven active learning.

    Science.gov (United States)

    Zhang, Bang; Wang, Yang; Chen, Fang

    2014-03-01

    Supervised machine learning techniques have been applied to multilabel image classification problems with tremendous success. Despite disparate learning mechanisms, their performances heavily rely on the quality of training images. However, the acquisition of training images requires significant efforts from human annotators. This hinders the applications of supervised learning techniques to large scale problems. In this paper, we propose a high-order label correlation driven active learning (HoAL) approach that allows the iterative learning algorithm itself to select the informative example-label pairs from which it learns so as to learn an accurate classifier with less annotation efforts. Four crucial issues are considered by the proposed HoAL: 1) unlike binary cases, the selection granularity for multilabel active learning need to be fined from example to example-label pair; 2) different labels are seldom independent, and label correlations provide critical information for efficient learning; 3) in addition to pair-wise label correlations, high-order label correlations are also informative for multilabel active learning; and 4) since the number of label combinations increases exponentially with respect to the number of labels, an efficient mining method is required to discover informative label correlations. The proposed approach is tested on public data sets, and the empirical results demonstrate its effectiveness.

  10. Cognitive Changes during Prolonged Stay at High Altitude and Its Correlation with C-Reactive Protein.

    Directory of Open Access Journals (Sweden)

    Sheng Li Hu

    Full Text Available Hypersensitive C-reaction protein (hsCRP may be a risk factor for cognitive impairment resulting from Alzheimer's disease (AD, stroke, and vascular dementia. This study explored the correlation of peripheral blood hsCRP level with cognitive decline due to high altitude exposure. The study was conducted on 100 male military participants who had never been to high altitude. Cerebral oxygen saturation monitoring, event related potentials (P300, N200 detection, and neurocognitive assessment was performed and total hsCRP, interleukin-6 (IL-6, and homocysteine was estimated at 500 m altitude, 3650 m altitude, 3 day, 1, and 3 month post arriving at the base camp (4400 m, and 1 month after coming back to the 500 m altitude. High altitude increased brain oxygen saturation, prolonged P300 and N200 latencies, injured cognitive functions, and raised plasma hsCRP levels. But they all recovered in varying degrees at 1 and 3 month post arriving at the base camp (4400 m. P300 latencies and hsCRP levels were strongly correlated to cognitive performances. These results suggested that cognitive deterioration occurred during the acute period of exposure to high altitude and may recover probably owning to acclimatization after extended stay at high altitude. Plasma hsCRP is inversely correlated to neurological cognition and it may be a potential biomarker for the prediction of high altitude induced cognitive dysfunction.

  11. Cognitive Changes during Prolonged Stay at High Altitude and Its Correlation with C-Reactive Protein

    Science.gov (United States)

    Hu, Sheng Li; Xiong, Wei; Dai, Zhi Qiang; Zhao, Heng Li; Feng, Hua

    2016-01-01

    Hypersensitive C-reaction protein (hsCRP) may be a risk factor for cognitive impairment resulting from Alzheimer’s disease (AD), stroke, and vascular dementia. This study explored the correlation of peripheral blood hsCRP level with cognitive decline due to high altitude exposure. The study was conducted on 100 male military participants who had never been to high altitude. Cerebral oxygen saturation monitoring, event related potentials (P300, N200) detection, and neurocognitive assessment was performed and total hsCRP, interleukin-6 (IL-6), and homocysteine was estimated at 500m altitude, 3650m altitude, 3day, 1, and 3 month post arriving at the base camp (4400m), and 1 month after coming back to the 500m altitude. High altitude increased brain oxygen saturation, prolonged P300 and N200 latencies, injured cognitive functions, and raised plasma hsCRP levels. But they all recovered in varying degrees at 1 and 3 month post arriving at the base camp (4400m). P300 latencies and hsCRP levels were strongly correlated to cognitive performances. These results suggested that cognitive deterioration occurred during the acute period of exposure to high altitude and may recover probably owning to acclimatization after extended stay at high altitude. Plasma hsCRP is inversely correlated to neurological cognition and it may be a potential biomarker for the prediction of high altitude induced cognitive dysfunction. PMID:26731740

  12. Study of $b\\bar{b}$ correlations in high energy proton-proton collisions

    CERN Document Server

    Aaij, Roel; LHCb Collaboration; Adinolfi, Marco; Ajaltouni, Ziad; Akar, Simon; Albrecht, Johannes; Alessio, Federico; Alexander, Michael; Alfonso Albero, Alejandro; Ali, Suvayu; Alkhazov, Georgy; Alvarez Cartelle, Paula; Alves Jr, Antonio Augusto; Amato, Sandra; Amerio, Silvia; Amhis, Yasmine; An, Liupan; Anderlini, Lucio; Andreassi, Guido; Andreotti, Mirco; Andrews, Jason; Appleby, Robert; Archilli, Flavio; d'Argent, Philippe; Arnau Romeu, Joan; Artamonov, Alexander; Artuso, Marina; Aslanides, Elie; Auriemma, Giulio; Baalouch, Marouen; Babuschkin, Igor; Bachmann, Sebastian; Back, John; Badalov, Alexey; Baesso, Clarissa; Baker, Sophie; Balagura, Vladislav; Baldini, Wander; Baranov, Alexander; Barlow, Roger; Barschel, Colin; Barsuk, Sergey; Barter, William; Baryshnikov, Fedor; Batozskaya, Varvara; Battista, Vincenzo; Bay, Aurelio; Beaucourt, Leo; Beddow, John; Bedeschi, Franco; Bediaga, Ignacio; Beiter, Andrew; Bel, Lennaert; Beliy, Nikita; Bellee, Violaine; Belloli, Nicoletta; Belous, Konstantin; Belyaev, Ivan; Ben-Haim, Eli; Bencivenni, Giovanni; Benson, Sean; Beranek, Sarah; Berezhnoy, Alexander; Bernet, Roland; Berninghoff, Daniel; Bertholet, Emilie; Bertolin, Alessandro; Betancourt, Christopher; Betti, Federico; Bettler, Marc-Olivier; van Beuzekom, Martinus; Bezshyiko, Iaroslava; Bifani, Simone; Billoir, Pierre; Birnkraut, Alex; Bitadze, Alexander; Bizzeti, Andrea; Bjørn, Mikkel; Blake, Thomas; Blanc, Frederic; Blouw, Johan; Blusk, Steven; Bocci, Valerio; Boettcher, Thomas; Bondar, Alexander; Bondar, Nikolay; Bonivento, Walter; Bordyuzhin, Igor; Borgheresi, Alessio; Borghi, Silvia; Borisyak, Maxim; Borsato, Martino; Bossu, Francesco; Boubdir, Meriem; Bowcock, Themistocles; Bowen, Espen Eie; Bozzi, Concezio; Braun, Svende; Britton, Thomas; Brodzicka, Jolanta; Brundu, Davide; Buchanan, Emma; Burr, Christopher; Bursche, Albert; Buytaert, Jan; Byczynski, Wiktor; Cadeddu, Sandro; Cai, Hao; Calabrese, Roberto; Calladine, Ryan; Calvi, Marta; Calvo Gomez, Miriam; Camboni, Alessandro; Campana, Pierluigi; Campora Perez, Daniel Hugo; Capriotti, Lorenzo; Carbone, Angelo; Carboni, Giovanni; Cardinale, Roberta; Cardini, Alessandro; Carniti, Paolo; Carson, Laurence; Carvalho Akiba, Kazuyoshi; Casse, Gianluigi; Cassina, Lorenzo; Castillo Garcia, Lucia; Cattaneo, Marco; Cavallero, Giovanni; Cenci, Riccardo; Chamont, David; Charles, Matthew; Charpentier, Philippe; Chatzikonstantinidis, Georgios; Chefdeville, Maximilien; Chen, Shanzhen; Cheung, Shu Faye; Chitic, Stefan-Gabriel; Chobanova, Veronika; Chrzaszcz, Marcin; Chubykin, Alexsei; Ciambrone, Paolo; Cid Vidal, Xabier; Ciezarek, Gregory; Clarke, Peter; Clemencic, Marco; Cliff, Harry; Closier, Joel; Cogan, Julien; Cogneras, Eric; Cogoni, Violetta; Cojocariu, Lucian; Collins, Paula; Colombo, Tommaso; Comerma-Montells, Albert; Contu, Andrea; Cook, Andrew; Coombs, George; Coquereau, Samuel; Corti, Gloria; Corvo, Marco; Costa Sobral, Cayo Mar; Couturier, Benjamin; Cowan, Greig; Craik, Daniel Charles; Crocombe, Andrew; Cruz Torres, Melissa Maria; Currie, Robert; D'Ambrosio, Carmelo; Da Cunha Marinho, Franciole; Dall'Occo, Elena; Dalseno, Jeremy; Davis, Adam; De Aguiar Francisco, Oscar; De Capua, Stefano; De Cian, Michel; De Miranda, Jussara; De Paula, Leandro; De Serio, Marilisa; De Simone, Patrizia; Dean, Cameron Thomas; Decamp, Daniel; Del Buono, Luigi; Dembinski, Hans Peter; Demmer, Moritz; Dendek, Adam; Derkach, Denis; Deschamps, Olivier; Dettori, Francesco; Dey, Biplab; Di Canto, Angelo; Di Nezza, Pasquale; Dijkstra, Hans; Dordei, Francesca; Dorigo, Mirco; Dosil Suárez, Alvaro; Douglas, Lauren; Dovbnya, Anatoliy; Dreimanis, Karlis; Dufour, Laurent; Dujany, Giulio; Durante, Paolo; Dzhelyadin, Rustem; Dziewiecki, Michal; Dziurda, Agnieszka; Dzyuba, Alexey; Easo, Sajan; Ebert, Marcus; Egede, Ulrik; Egorychev, Victor; Eidelman, Semen; Eisenhardt, Stephan; Eitschberger, Ulrich; Ekelhof, Robert; Eklund, Lars; Ely, Scott; Esen, Sevda; Evans, Hannah Mary; Evans, Timothy; Falabella, Antonio; Farley, Nathanael; Farry, Stephen; Fay, Robert; Fazzini, Davide; Federici, Luca; Ferguson, Dianne; Fernandez, Gerard; Fernandez Declara, Placido; Fernandez Prieto, Antonio; Ferrari, Fabio; Ferreira Rodrigues, Fernando; Ferro-Luzzi, Massimiliano; Filippov, Sergey; Fini, Rosa Anna; Fiore, Marco; Fiorini, Massimiliano; Firlej, Miroslaw; Fitzpatrick, Conor; Fiutowski, Tomasz; Fleuret, Frederic; Fohl, Klaus; Fontana, Marianna; Fontanelli, Flavio; Forshaw, Dean Charles; Forty, Roger; Franco Lima, Vinicius; Frank, Markus; Frei, Christoph; Fu, Jinlin; Funk, Wolfgang; Furfaro, Emiliano

    2017-01-01

    Kinematic correlations for pairs of beauty hadrons, produced in high energy proton-proton collisions, are studied. The data sample used was collected with the LHCb experiment at centre-of-mass energies of 7 and 8 TeV and corresponds to an integrated luminosity of 3 fb$^{-1}$ The measurement is performed using inclusive $b\\rightarrow J/\\psi X$ decays in the rapidity range $2 < y^{J/\\psi} <4.5$. The observed correlations are in good agreement with theoretical predictions.

  13. Modal Test/Calculation Correlation Study on the Lower Crankcase of High-Duty Diesel Engine

    Institute of Scientific and Technical Information of China (English)

    冯慧华; 左正兴; 廖日东; 张儒华

    2004-01-01

    To set up the dynamic FEM model of a high-duty diesel's lower crankcase with sufficient precision, modal correlation research on tested and calculated modes have been fulfilled. MACs between each mode pairs, CoMACs and ECoMACs on each node of modal testing model have been calculated. On the assistant of modal shape comparison, MACs could afford information about correlating relations between tested and calculated mode groups. CoMACs and ECoMACs have pointed out the direction of structure modification to FEM model. The results of the study show that the analytic model built has a certain degree of accuracy.

  14. High Resolution Pulse Compression Imaging Using Super Resolution FM-Chirp Correlation Method (SCM)

    Science.gov (United States)

    Fujiwara, M.; Okubo, K.; Tagawa, N.

    This study addresses the issue of the super-resolution pulse compression technique (PCT) for ultrasound imaging. Time resolution of multiple ultrasonic echoes using the FM-Chirp PCT is limited by the bandwidth of the sweep-frequency. That is, the resolution depends on the sharpness of auto-correlation function. We propose the Super resolution FM-Chirp correlation Method (SCM) and evaluate its performance. This method is based on the multiple signal classification (MUSIC) algorithm. Our simulations were made for the model assuming multiple signals reflected from some scatterers. We confirmed that SCM detects time delay of complicated reflected signals successfully with high resolution.

  15. Correlated double electron capture in slow, highly charged ion-atom collisions

    Energy Technology Data Exchange (ETDEWEB)

    Stolterfoht, N.; Havener, C.C.; Phaneuf, R.A.; Swenson, J.K.; Shafroth, S.M.; Meyer, F.W.

    1986-01-01

    Recent measurements of autoionization electrons produced in slow, highly charged ion-atom collisions are reviewed. Mechanisms for double electron capture into equivalent and nonequivalent configurations are analyzed by comparing the probabilities for the creation of L/sub 1/L/sub 23/X Coster Kronig electrons and L-Auger electrons. It is shown that the production of the Coster-Kronig electrons is due to electron correlation effects whose analysis leads beyond the independent-particle model. The importance of correlation effects on different capture mechanisms is discussed. 28 refs., 6 figs.

  16. Low Speed and High Speed Correlation of SMART Active Flap Rotor Loads

    Science.gov (United States)

    Kottapalli, Sesi B. R.

    2010-01-01

    Measured, open loop and closed loop data from the SMART rotor test in the NASA Ames 40- by 80- Foot Wind Tunnel are compared with CAMRAD II calculations. One open loop high-speed case and four closed loop cases are considered. The closed loop cases include three high-speed cases and one low-speed case. Two of these high-speed cases include a 2 deg flap deflection at 5P case and a test maximum-airspeed case. This study follows a recent, open loop correlation effort that used a simple correction factor for the airfoil pitching moment Mach number. Compared to the earlier effort, the current open loop study considers more fundamental corrections based on advancing blade aerodynamic conditions. The airfoil tables themselves have been studied. Selected modifications to the HH-06 section flap airfoil pitching moment table are implemented. For the closed loop condition, the effect of the flap actuator is modeled by increased flap hinge stiffness. Overall, the open loop correlation is reasonable, thus confirming the basic correctness of the current semi-empirical modifications; the closed loop correlation is also reasonable considering that the current flap model is a first generation model. Detailed correlation results are given in the paper.

  17. High Capsid–Genome Correlation Facilitates Creation of AAV Libraries for Directed Evolution

    Science.gov (United States)

    Nonnenmacher, Mathieu; van Bakel, Harm; Hajjar, Roger J; Weber, Thomas

    2015-01-01

    Directed evolution of adeno-associated virus (AAV) through successive rounds of phenotypic selection is a powerful method to isolate variants with improved properties from large libraries of capsid mutants. Importantly, AAV libraries used for directed evolution are based on the “natural” AAV genome organization where the capsid proteins are encoded in cis from replicating genomes. This is necessary to allow the recovery of the capsid DNA after each step of phenotypic selection. For directed evolution to be used successfully, it is essential to minimize the random mixing of capsomers and the encapsidation of nonmatching viral genomes during the production of the viral libraries. Here, we demonstrate that multiple AAV capsid variants expressed from Rep/Cap containing viral genomes result in near-homogeneous capsids that display an unexpectedly high capsid–DNA correlation. Next-generation sequencing of AAV progeny generated by bulk transfection of a semi-random peptide library showed a strong counter-selection of capsid variants encoding premature stop codons, which further supports a strong capsid–genome identity correlation. Overall, our observations demonstrate that production of “natural” AAVs results in low capsid mosaicism and high capsid–genome correlation. These unique properties allow the production of highly diverse AAV libraries in a one-step procedure with a minimal loss in phenotype–genotype correlation. PMID:25586687

  18. High capsid-genome correlation facilitates creation of AAV libraries for directed evolution.

    Science.gov (United States)

    Nonnenmacher, Mathieu; van Bakel, Harm; Hajjar, Roger J; Weber, Thomas

    2015-04-01

    Directed evolution of adeno-associated virus (AAV) through successive rounds of phenotypic selection is a powerful method to isolate variants with improved properties from large libraries of capsid mutants. Importantly, AAV libraries used for directed evolution are based on the "natural" AAV genome organization where the capsid proteins are encoded in cis from replicating genomes. This is necessary to allow the recovery of the capsid DNA after each step of phenotypic selection. For directed evolution to be used successfully, it is essential to minimize the random mixing of capsomers and the encapsidation of nonmatching viral genomes during the production of the viral libraries. Here, we demonstrate that multiple AAV capsid variants expressed from Rep/Cap containing viral genomes result in near-homogeneous capsids that display an unexpectedly high capsid-DNA correlation. Next-generation sequencing of AAV progeny generated by bulk transfection of a semi-random peptide library showed a strong counter-selection of capsid variants encoding premature stop codons, which further supports a strong capsid-genome identity correlation. Overall, our observations demonstrate that production of "natural" AAVs results in low capsid mosaicism and high capsid-genome correlation. These unique properties allow the production of highly diverse AAV libraries in a one-step procedure with a minimal loss in phenotype-genotype correlation.

  19. Pearson Syndrome: A Retrospective Cohort Study from the Marrow Failure Study Group of A.I.E.O.P. (Associazione Italiana Emato-Oncologia Pediatrica).

    Science.gov (United States)

    Farruggia, Piero; Di Cataldo, Andrea; Pinto, Rita M; Palmisani, Elena; Macaluso, Alessandra; Valvo, Laura Lo; Cantarini, Maria E; Tornesello, Assunta; Corti, Paola; Fioredda, Francesca; Varotto, Stefania; Martire, Baldo; Moroni, Isabella; Puccio, Giuseppe; Russo, Giovanna; Dufour, Carlo; Pillon, Marta

    2016-01-01

    Pearson syndrome (PS) is a very rare and often fatal multisystemic mitochondrial disorder involving the liver, kidney, pancreas, and hematopoietic and central nervous system. It is characterized principally by a transfusion-dependent anemia that usually improves over time, a tendency to develop severe infections, and a high mortality rate. We describe a group of 11 PS patients diagnosed in Italy in the period 1993-2014. The analysis of this reasonably sized cohort of patients contributes to the clinical profile of the disease and highlights a rough incidence of 1 case/million newborns. Furthermore, it seems that some biochemical parameters like increased serum alanine and urinary fumaric acid can help to address an early diagnosis.

  20. Correlating the ancient Maya and modern European calendars with high-precision AMS 14C dating.

    Science.gov (United States)

    Kennett, Douglas J; Hajdas, Irka; Culleton, Brendan J; Belmecheri, Soumaya; Martin, Simon; Neff, Hector; Awe, Jaime; Graham, Heather V; Freeman, Katherine H; Newsom, Lee; Lentz, David L; Anselmetti, Flavio S; Robinson, Mark; Marwan, Norbert; Southon, John; Hodell, David A; Haug, Gerald H

    2013-01-01

    The reasons for the development and collapse of Maya civilization remain controversial and historical events carved on stone monuments throughout this region provide a remarkable source of data about the rise and fall of these complex polities. Use of these records depends on correlating the Maya and European calendars so that they can be compared with climate and environmental datasets. Correlation constants can vary up to 1000 years and remain controversial. We report a series of high-resolution AMS (14)C dates on a wooden lintel collected from the Classic Period city of Tikal bearing Maya calendar dates. The radiocarbon dates were calibrated using a Bayesian statistical model and indicate that the dates were carved on the lintel between AD 658-696. This strongly supports the Goodman-Martínez-Thompson (GMT) correlation and the hypothesis that climate change played an important role in the development and demise of this complex civilization.

  1. Depict noise-driven nonlinear dynamic networks from output data by using high-order correlations

    CERN Document Server

    Chen, Yang; Chen, Tianyu; Wang, Shihong; Hu, Gang

    2016-01-01

    Many practical systems can be described by dynamic networks, for which modern technique can measure their output signals, and accumulate extremely rich data. Nevertheless, the network structures producing these data are often deeply hidden in these data. Depicting network structures by analysing the available data turns to be significant inverse problems. On one hand, dynamics are often driven by various unknown facts, called noises. On the other hand, network structures of practical systems are commonly nonlinear, and different nonlinearities can provide rich dynamic features and meaningful functions of realistic networks. So far, no method, both theoretically or numerically, has been found to systematically treat the both difficulties together. Here we propose to use high-order correlation computations (HOCC) to treat nonlinear dynamics; use two-time correlations to treat noise effects; and use suitable basis and correlator vectors to unifiedly depict all dynamic nonlinearities and topological interaction l...

  2. 儿童高度近视性散光与眼轴长度相关性分析%A correlation analysis on children’s high myopic astigmatism and axial length

    Institute of Scientific and Technical Information of China (English)

    胡丰平; 魏春惠; 金卫平

    2014-01-01

    Objective To study the Correlation between high myopic astigmatism and axial length.Methods 148 eyes of 93 cases with high myopic astigmatism were studied,whose eye’s total astigmatism,corneal astigmatism and axial length were measured,and their cor-relation were also analyzed.Results The mean eye’s total astigmatism is (4.04 ±1.27)D,the mean corneal astigmatism is (3.74 ±1.08) D,the mean axial length is (24.23 ±1.32)mm in 148 eyes of93 cases.The Pearson Correlation Analysis was used to analyze all ofthe above data.There is no obvious correlation between the astigmatism and the axial length.Conclusion There is no obvious correlation between the astigmatism and the axial length.%目的:了解儿童高度近视性散光度与眼轴长度有无关联性。方法对93例(148眼)高度近视性散光儿童散光度和眼轴长度进行测量,分析散光度与眼轴长度之间的相关性。结果93例148眼的眼总合散光度平均为(4.04±1.27)D,角膜散光度平均为(3.74±1.08)D;眼轴长度平均为(24.23±1.32)mm,经Pearson相关分析,散光度与眼轴长度相关性没有统计学意义。结论儿童高度近视散光度与眼轴长度没有相关性。

  3. Missing correlation of retinal vessel diameter with high-altitude headache

    Science.gov (United States)

    Willmann, Gabriel; Fischer, M Dominik; Schommer, Kai; Bärtsch, Peter; Gekeler, Florian; Schatz, Andreas

    2014-01-01

    The most common altitude-related symptom, high-altitude headache (HAH), has recently been suggested to originate from restricted cerebral venous drainage in the presence of increased inflow caused by hypoxia. In support of this novel hypothesis, retinal venous distension was shown to correlate with the degree of HAH. We quantified for the first time retinal vessel diameter changes at 4559 m using infrared fundus images obtained from a state of the art Spectralis™ HRA+OCT with a semiautomatic VesselMap 1® software. High-altitude exposure resulted in altered arterial and venous diameter changes at high altitude, however, independent of headache burden. PMID:25356382

  4. Linear correlation analysis in finding interactions: Half of predicted interactions are undeterministic and one-third of candidate direct interactions are missed

    OpenAIRE

    WenJun Zhang; Xin Li

    2015-01-01

    An ecological network can be constructed by calculating the sampling data of taxon by sample type. A statistically significant Pearson linear correlation means an indirect or direct linear interaction between two taxa, and a statistically significant partial correlation based on Pearson linear correlation, due to elimination of indirect effects of other taxa, means a candidate direct interaction between two taxa. People always use Pearson linear correlation to find interactions. However, some...

  5. High Fibrinogen in Peripheral Blood Correlates with Poorer Hearing Recovery in Idiopathic Sudden Sensorineural Hearing Loss

    Science.gov (United States)

    Kanzaki, Sho; Sakagami, Masafumi; Hosoi, Hiroshi; Murakami, Shingo; Ogawa, Kaoru

    2014-01-01

    Objectives We used hearing tests and peripheral blood sample analyses to characterize the pathology of idiopathic sudden sensorineural hearing loss (ISSNHL) and to identify possible prognostic factors for predicting recovery of hearing loss. Study Design A retrospective, multicenter trial was conducted. Methods Two hundred three patients examined within 7 days after the onset of ISSNHL received prednisone with lipo-prostaglandin E1. Pure-tone auditory tests were performed before and after treatment with these drugs. Blood tests were performed on blood samples collected during the patients’ initial visit to our clinic. Results In all patients, elevated white blood cell (WBC) counts, fasting blood sugar levels, HgbA1c, and erythrocyte sedimentation rate (ESR) significantly correlated with high hearing threshold measurements obtained on the initial visit. High fibrinogen levels, WBC counts, ESR, and low concentrations of fibrinogen degradation products (FDP) were associated with lower hearing recovery rates. Additionally, different audiogram shapes correlated with different blood test factors, indicating that different pathologies were involved. Conclusions High fibrinogen levels measured within seven days after ISSNHL onset correlated with poorer hearing recovery. This may be a consequence of ischemia or infections in the inner ear. The high WBC counts also observed may therefore reflect an immune response to inner ear damage induced by ischemic changes or infections. Our data indicate that therapeutic strategies should be selected based on the timing of initial treatment relative to ISSNHL onset. PMID:25166620

  6. High fibrinogen in peripheral blood correlates with poorer hearing recovery in idiopathic sudden sensorineural hearing loss.

    Directory of Open Access Journals (Sweden)

    Sho Kanzaki

    Full Text Available OBJECTIVES: We used hearing tests and peripheral blood sample analyses to characterize the pathology of idiopathic sudden sensorineural hearing loss (ISSNHL and to identify possible prognostic factors for predicting recovery of hearing loss. STUDY DESIGN: A retrospective, multicenter trial was conducted. METHODS: Two hundred three patients examined within 7 days after the onset of ISSNHL received prednisone with lipo-prostaglandin E1. Pure-tone auditory tests were performed before and after treatment with these drugs. Blood tests were performed on blood samples collected during the patients' initial visit to our clinic. RESULTS: In all patients, elevated white blood cell (WBC counts, fasting blood sugar levels, HgbA1c, and erythrocyte sedimentation rate (ESR significantly correlated with high hearing threshold measurements obtained on the initial visit. High fibrinogen levels, WBC counts, ESR, and low concentrations of fibrinogen degradation products (FDP were associated with lower hearing recovery rates. Additionally, different audiogram shapes correlated with different blood test factors, indicating that different pathologies were involved. CONCLUSIONS: High fibrinogen levels measured within seven days after ISSNHL onset correlated with poorer hearing recovery. This may be a consequence of ischemia or infections in the inner ear. The high WBC counts also observed may therefore reflect an immune response to inner ear damage induced by ischemic changes or infections. Our data indicate that therapeutic strategies should be selected based on the timing of initial treatment relative to ISSNHL onset.

  7. Correlation between Health Perception, Body Image, and Eating Habits in High School Students

    Directory of Open Access Journals (Sweden)

    Abdullah Ichsan

    2016-06-01

    Full Text Available Background: Mental disorders, including eating disorders, mostly begin during youth. Moreover, negative body image is found to cause unhealthy eating habits in the context of several cross-cultural settings. This study aimed to examine the correlation between health perception and body image with eating habits among high school students. Methods: A structured, anonymous questionnaire was distributed to students of a private high school in Bandung, Indonesia in June-October 2014. The questionnaire included questions about health perception, body image, eating habits, body weight and height, and also other demographic parameters. The school was selected as the study object through purposive sampling, and 140 high school students (72 male and 68 female were ramdomly selected. Results: Male and female did not show considerable differences in health perceptions. Out of 13 statements, 12 statements of male respondents showed better body image than female. While in eating habits statements, female respondents seemed to maintain healthier eating habits than male respondents. No significant correlation was observed between body image and eating habits (r=-0.015, p=0.858. There was significant correlation between health perception and eating habits (r=0.374, p<0.001. Correlation between sex and eating habits was found (p=0.020, there was not significant relationship between eating habits and Body Mass Index (BMI (p=0.368. Conclusions: The negative relationship between body image and eating habits is not significant. However there was a significant positive relationship between health perception and eating habits. Furthermore, there was correlation between sex and eating habits, while the positive relationship between eating habits and BMI was still not found.

  8. Fluorescence correlation spectroscopy as tool for high-content-screening in yeast (HCS-FCS)

    Science.gov (United States)

    Wood, Christopher; Huff, Joseph; Marshall, Will; Yu, Elden Qingfeng; Unruh, Jay; Slaughter, Brian; Wiegraebe, Winfried

    2011-03-01

    To measure protein interactions, diffusion properties, and local concentrations in single cells, Fluorescence Correlation Spectroscopy (FCS) is a well-established and widely accepted method. However, measurements can take a long time and are laborious. Therefore investigations are typically limited to tens or a few hundred cells. We developed an automated system to overcome these limitations and make FCS available for High Content Screening (HCS). We acquired data in an auto-correlation screen of more than 4000 of the 6000 proteins of the yeast Saccharomyces cerevisiae, tagged with eGFP and expanded the HCS to use cross-correlation between eGFP and mCherry tagged proteins to screen for molecular interactions. We performed all high-content FCS screens (HCS-FCS) in a 96 well plate format. The system is based on an extended Carl Zeiss fluorescence correlation spectrometer ConfoCor 3 attached to a confocal microscope LSM 510. We developed image-processing software to control these hardware components. The confocal microscope obtained overview images and we developed an algorithm to search for and detect single cells. At each cell, we positioned a laser beam at a well-defined point and recorded the fluctuation signal. We used automatic scoring of the signal for quality control. All data was stored and organized in a database based on the open source Open Microscopy Environment (OME) platform. To analyze the data we used the image processing language IDL and the open source statistical software package R.

  9. High correlation of Middle East respiratory syndrome spread with Google search and Twitter trends in Korea

    Science.gov (United States)

    Shin, Soo-Yong; Seo, Dong-Woo; An, Jisun; Kwak, Haewoon; Kim, Sung-Han; Gwack, Jin; Jo, Min-Woo

    2016-09-01

    The Middle East respiratory syndrome coronavirus (MERS-CoV) was exported to Korea in 2015, resulting in a threat to neighboring nations. We evaluated the possibility of using a digital surveillance system based on web searches and social media data to monitor this MERS outbreak. We collected the number of daily laboratory-confirmed MERS cases and quarantined cases from May 11, 2015 to June 26, 2015 using the Korean government MERS portal. The daily trends observed via Google search and Twitter during the same time period were also ascertained using Google Trends and Topsy. Correlations among the data were then examined using Spearman correlation analysis. We found high correlations (>0.7) between Google search and Twitter results and the number of confirmed MERS cases for the previous three days using only four simple keywords: “MERS”, “” (“MERS (in Korean)”), “” (“MERS symptoms (in Korean)”), and “” (“MERS hospital (in Korean)”). Additionally, we found high correlations between the Google search and Twitter results and the number of quarantined cases using the above keywords. This study demonstrates the possibility of using a digital surveillance system to monitor the outbreak of MERS.

  10. High correlation of Middle East respiratory syndrome spread with Google search and Twitter trends in Korea.

    Science.gov (United States)

    Shin, Soo-Yong; Seo, Dong-Woo; An, Jisun; Kwak, Haewoon; Kim, Sung-Han; Gwack, Jin; Jo, Min-Woo

    2016-09-06

    The Middle East respiratory syndrome coronavirus (MERS-CoV) was exported to Korea in 2015, resulting in a threat to neighboring nations. We evaluated the possibility of using a digital surveillance system based on web searches and social media data to monitor this MERS outbreak. We collected the number of daily laboratory-confirmed MERS cases and quarantined cases from May 11, 2015 to June 26, 2015 using the Korean government MERS portal. The daily trends observed via Google search and Twitter during the same time period were also ascertained using Google Trends and Topsy. Correlations among the data were then examined using Spearman correlation analysis. We found high correlations (>0.7) between Google search and Twitter results and the number of confirmed MERS cases for the previous three days using only four simple keywords: "MERS", " ("MERS (in Korean)"), " ("MERS symptoms (in Korean)"), and " ("MERS hospital (in Korean)"). Additionally, we found high correlations between the Google search and Twitter results and the number of quarantined cases using the above keywords. This study demonstrates the possibility of using a digital surveillance system to monitor the outbreak of MERS.

  11. Azimuthal anisotropy harmonics from long-range correlations in high multiplicity pp collisions at CMS

    Science.gov (United States)

    Chen, Zhenyu

    2016-12-01

    Measurements of two-particle angular correlations in pp collisions at √{ s} = 7 TeV are presented as a function of charged-particle multiplicities. The data, corresponding to an integrated luminosity of about 6.2 pb-1, were collected during the 2010 LHC pp run using the CMS detector. In high-multiplicity events, a long-range (| Δη | > 2), near-side (Δϕ ≈ 0) structure is found in the two-particle Δη - Δϕ correlation functions. The second-order (v2) and third-order (v3) azimuthal anisotropy harmonics of charged particles, KS0 and Λ / Λ ‾ particles are extracted from long-range two-particle correlations as a function of particle multiplicity and transverse momentum, after correcting for the contribution of back-to-back jet correlations. A v2 and v3 value of about 4% and 1%, averaging over 0.3 high-multiplicity region, and are found to be smaller than values obtained in pPb and PbPb collisions at similar multiplicities.

  12. High-dynamic-range cross-correlator for shot-to-shot measurement of temporal contrast

    Science.gov (United States)

    Kon, Akira; Nishiuchi, Mamiko; Kiriyama, Hiromitsu; Ogura, Koichi; Mori, Michiaki; Sakaki, Hironao; Kando, Masaki; Kondo, Kiminori

    2017-01-01

    The temporal contrast of an ultrahigh-intensity laser is a crucial parameter for laser plasma experiments. We have developed a multichannel cross-correlator (MCCC) for single-shot measurements of the temporal contrast in a high-power laser system. The MCCC is based on third-order cross-correlation, and has four channels and independent optical delay lines. We have experimentally demonstrated that the MCCC system achieves a high dynamic range of ˜1012 and a large temporal window of ˜1 ns. Moreover, we were able to measure the shot-to-shot fluctuations of a short-prepulse intensity at -26 ps and long-pulse (amplified spontaneous emission, ASE) intensities at -30, -450, and -950 ps before the arrival of the main pulse at the interaction point.

  13. Inductive inference or inductive behavior: Fisher and Neyman-Pearson approaches to statistical testing in psychological research (1940-1960).

    Science.gov (United States)

    Halpin, Peter F; Stam, Henderikus J

    2006-01-01

    The application of statistical testing in psychological research over the period of 1940-1960 is examined in order to address psychologists' reconciliation of the extant controversy between the Fisher and Neyman-Pearson approaches. Textbooks of psychological statistics and the psychological journal literature are reviewed to examine the presence of what Gigerenzer (1993) called a hybrid model of statistical testing. Such a model is present in the textbooks, although the mathematically incomplete character of this model precludes the appearance of a similarly hybridized approach to statistical testing in the research literature. The implications of this hybrid model for psychological research and the statistical testing controversy are discussed.

  14. Galactic Synchrotron Emission and the Far-infrared-Radio Correlation at High Redshift

    Science.gov (United States)

    Schober, J.; Schleicher, D. R. G.; Klessen, R. S.

    2016-08-01

    Theoretical scenarios, including the turbulent small-scale dynamo, predict that strong magnetic fields already exist in young galaxies. Based on the assumption of energy equipartition between magnetic fields and turbulence, we determine the galactic synchrotron flux as a function of redshift z. Galaxies in the early universe are different from local galaxies, in particular, the former have more intense star formation. To cover a large range of conditions, we consider two different systems: one model galaxy comparable to the Milky Way and one typical high-z starburst galaxy. We include a model of the steady-state cosmic ray spectrum and find that synchrotron emission can be detected up to cosmological redshifts with current and future radio telescopes. The turbulent dynamo theory is in agreement with the origin of the observed correlation between the far-infrared (FIR) luminosity L FIR and the radio luminosity L radio. Our model reproduces this correlation well at z = 0. We extrapolate the FIR-radio correlation to higher redshifts and predict a time evolution with a significant deviation from its present-day appearance already at z≈ 2 for a gas density that increases strongly with z. In particular, we predict a decrease of the radio luminosity with redshift which is caused by the increase of cosmic ray energy losses at high z. The result is an increase of the ratio between L FIR and L radio. Simultaneously, we predict that the slope of the FIR-radio correlation becomes shallower with redshift. This behavior of the correlation could be observed in the near future with ultra-deep radio surveys.

  15. Reducing Bias and Error in the Correlation Coefficient Due to Nonnormality

    Science.gov (United States)

    Bishara, Anthony J.; Hittner, James B.

    2015-01-01

    It is more common for educational and psychological data to be nonnormal than to be approximately normal. This tendency may lead to bias and error in point estimates of the Pearson correlation coefficient. In a series of Monte Carlo simulations, the Pearson correlation was examined under conditions of normal and nonnormal data, and it was compared…

  16. Reducing Bias and Error in the Correlation Coefficient Due to Nonnormality

    Science.gov (United States)

    Bishara, Anthony J.; Hittner, James B.

    2015-01-01

    It is more common for educational and psychological data to be nonnormal than to be approximately normal. This tendency may lead to bias and error in point estimates of the Pearson correlation coefficient. In a series of Monte Carlo simulations, the Pearson correlation was examined under conditions of normal and nonnormal data, and it was compared…

  17. Kinematical Correlations for Higgs Boson Plus High P_{T} Jet Production at Hadron Colliders.

    Science.gov (United States)

    Sun, Peng; Yuan, C-P; Yuan, Feng

    2015-05-22

    We investigate the effect of QCD resummation to kinematical correlations in the Higgs boson plus high transverse momentum (P(T)) jet events produced at hadron colliders. We show that at the complete one-loop order, the Collins-Soper-Sterman resummation formalism can be applied to derive the Sudakov form factor. We compare the singular behavior of resummation calculation to fixed order prediction in the case that a Higgs boson and high P(T) jet are produced nearly back to back in their transverse momenta, and find perfect agreement. The phenomenological importance of the resummation effect at the LHC is also demonstrated.

  18. Correlation of Electrical Noise with Non-radiative Current for High Power QWLs

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The characteristics of low-frequency electrical noise, voltage-current (V-I) and electrical derivation for 980nm InGaAsP/InGaAs/GaAs high power double quantum well lasers(DQWLs) are measured under different conditions. The correlation of the low-frequency electrical noise with surface non-radiative current of devices is discussed. The results indicate the low-frequency electrical noise of 980nm DQWLs with high power is mainly 1/f noise and has good relation with the device surface current at low injection.

  19. On The Origin Of High Energy Correlations in Gamma-ray Bursts

    Energy Technology Data Exchange (ETDEWEB)

    Kocevski, Daniel

    2012-04-03

    I investigate the origin of the observed correlation between a gamma-ray burst's {nu}F{sub {nu}} spectral peak E{sub pk} and its isotropic equivalent energy E{sub iso} through the use of a population synthesis code to model the prompt gamma-ray emission from GRBs. By using prescriptions for the distribution of prompt spectral parameters as well as the population's luminosity function and co-moving rate density, I generate a simulated population of GRBs and examine how bursts of varying spectral properties and redshift would appear to a gamma-ray detector here on Earth. I find that a strong observed correlation can be produced between the source frame Epk and Eiso for the detected population despite the existence of only a weak and broad correlation in the original simulated population. The energy dependance of a gamma-ray detector's flux-limited detection threshold acts to produce a correlation between the source frame E{sub pk} and E{sub iso} for low luminosity GRBs, producing the left boundary of the observed correlation. Conversely, very luminous GRBs are found at higher redshifts than their low luminosity counterparts due to the standard Malquest bias, causing bursts in the low E{sub pk}, high E{sub iso} regime to go undetected because their E{sub pk} values would be redshifted to energies at which most gamma-ray detectors become less sensitive. I argue that it is this previously unexamined effect which produces the right boundary of the observed correlation. Therefore, the origin of the observed correlation is a complex combination of the instrument's detection threshold, the intrinsic cutoff in the GRB luminosity function, and the broad range of redshifts over which GRBs are detected. Although the GRB model presented here is a very simplified representation of the complex nature of GRBs, these simulations serve to demonstrate how selection effects caused by a combination of instrumental sensitivity and the cosmological nature of an

  20. Chandra Survey of Nearby Highly Inclined Disc Galaxies - II: Correlation Analysis of Galactic Coronal Properties

    CERN Document Server

    Li, Jiang-Tao

    2013-01-01

    X-ray observations provide a key tool for exploring the properties of galactic coronae and their formation processes. In an earlier paper, we have presented a Chandra data analysis of the coronae of 53 nearby highly-inclined disc galaxies. Here we study the correlation of the X-ray measurements with other galaxy properties and compare the results with those obtained for elliptical galaxies. A good correlation is present between the coronal luminosity Lx and the SFR. But we find a better correlation between Lx and the total SN mechanical energy input rate (ESN), including the expected contribution from core collapsed (CC) and Ia SNe. The X-ray radiation efficiency (eta=Lx/ESN) has a mean value of ~0.4% with an rms of ~0.5dex. eta further correlates with MTF/M* (MTF is the baryon mass measured from the rotation velocity and the Tully-Fisher relation, M* is the stellar mass measured from the K-band luminosity) and the CC SN rate surface density (FSN, in units of SN/yr/kpc^2), which can be characterized as: eta=0...

  1. Vortical fluid and $\\Lambda$ spin correlations in high-energy heavy-ion collisions

    CERN Document Server

    Pang, Long-Gang; Wang, Qun; Wang, Xin-Nian

    2016-01-01

    Fermions become polarized in a vortical fluid due to spin-vorticity coupling. The spin polarization density is proportional to the local fluid vorticity at the next-to-leading order of a gradient expansion in a quantum kinetic theory. Spin correlations of two $\\Lambda$-hyperons can therefore reveal the vortical structure of the dense matter in high-energy heavy-ion collisions. We employ a (3+1)D viscous hydrodynamic model with event-by-event fluctuating initial conditions from A MultiPhase Transport (AMPT) model to calculate the vorticity distributions and $\\Lambda$ spin correlations. The azimuthal correlation of the transverse spin is shown to have a cosine form plus an offset due to a circular structure of the transverse vorticity around the beam direction and global spin polarization. The longitudinal spin correlation shows a structure of vortex-pairing in the transverse plane due to the convective flow of hot spots in the radial direction. The dependence on colliding energy, rapidity, centrality and sensi...

  2. High molecular weight adiponectin correlates positively with myeloperoxidase in patients with type 2 diabetes mellitus.

    Science.gov (United States)

    Bobbert, P; Rauch, U; Stratmann, B; Goldin-Lang, P; Antoniak, S; Bobbert, T; Schultheiss, H P; Tschoepe, D

    2008-11-01

    Adiponectin (APN) is present in human plasma as a low molecular weight (LMW), a middle molecular weight (MMW) and a high molecular weight form (HMW). As a support to determine properties such as anti-atherogenic or atherogenic effects, recent clinical studies suppose to determine the ratio of each APN multimer to total APN but not the absolute plasma concentration of APN. In the present study, the correlation of APN and its multimers with myeloperoxidase (MPO), an enzyme with pro-inflammatory properties, was examined in patients with type 2 diabetes mellitus. MPO and APN serum levels were assessed in 49 patients with type 2 diabetes mellitus at the beginning and at the end of an anti-diabetic treatment. After treatment a significant increase in the ratio of HMW to total APN (from 0.43+/-0.16 to 0.59+/-0.14, p<0.05) was found. Before treatment, HMW-APN was correlated positively with MPO (r=0.314, p<0.05). Moreover, a positive correlation was observed between the increased HMW ratio and MPO during treatment (r=0.304, p<0.05). HMW-APN correlates positively with MPO in patients with type 2 diabetes. Therefore, HMW-APN may exert possible pro-inflammatory effects in type 2 diabetes.

  3. Depth imaging in highly scattering underwater environments using time-correlated single-photon counting

    Science.gov (United States)

    Maccarone, Aurora; McCarthy, Aongus; Halimi, Abderrahim; Tobin, Rachael; Wallace, Andy M.; Petillot, Yvan; McLaughlin, Steve; Buller, Gerald S.

    2016-10-01

    This paper presents an optical depth imaging system optimized for highly scattering environments such as underwater. The system is based on the time-correlated single-photon counting (TCSPC) technique and the time-of-flight approach. Laboratory-based measurements demonstrate the potential of underwater depth imaging, with specific attention given to environments with a high level of scattering. The optical system comprised a monostatic transceiver unit, a fiber-coupled supercontinuum laser source with a wavelength tunable acousto-optic filter (AOTF), and a fiber-coupled single-element silicon single-photon avalanche diode (SPAD) detector. In the optical system, the transmit and receive channels in the transceiver unit were overlapped in a coaxial optical configuration. The targets were placed in a 1.75 meter long tank, and raster scanned using two galvo-mirrors. Laboratory-based experiments demonstrate depth profiling performed with up to nine attenuation lengths between the transceiver and target. All of the measurements were taken with an average laser power of less than 1mW. Initially, the data was processed using a straightforward pixel-wise cross-correlation of the return timing signal with the system instrumental timing response. More advanced algorithms were then used to process these cross-correlation results. These results illustrate the potential for the reconstruction of images in highly scattering environments, and to permit the investigation of much shorter acquisition time scans. These algorithms take advantage of the data sparseness under the Discrete Cosine Transform (DCT) and the correlation between adjacent pixels, to restore the depth and reflectivity images.

  4. High-resolution CT with histopathological correlates of the classic metaphyseal lesion of infant abuse

    Energy Technology Data Exchange (ETDEWEB)

    Tsai, Andy; Kleinman, Paul K. [Boston Children' s Hospital, Department of Radiology, Boston, MA (United States); McDonald, Anna G. [Office of the Chief Medical Examiner, Boston, MA (United States); Rosenberg, Andrew E. [University of Miami Hospital, Department of Pathology, Miami, FL (United States); Gupta, Rajiv [Massachusetts General Hospital, Department of Radiology, Boston, MA (United States)

    2014-02-15

    The classic metaphyseal lesion (CML) is a common high specificity indicator of infant abuse and its imaging features have been correlated histopathologically in infant fatalities. High-resolution CT imaging and histologic correlates were employed to (1) characterize the normal infant anatomy surrounding the chondro-osseous junction, and (2) confirm the 3-D model of the CML previously inferred from planar radiography and histopathology. Long bone specimens from 5 fatally abused infants, whose skeletal survey showed definite or suspected CMLs, were studied postmortem. After skeletal survey, selected specimens were resected and imaged with high-resolution digital radiography. They were then scanned with micro-CT (isotropic resolution of 45 μm{sup 3}) or with high-resolution flat-panel CT (isotropic resolutions of 200 μm{sup 3}). Visualization of the bony structures was carried out using image enhancement, segmentation and isosurface extraction, together with volume rendering and multiplanar reformatting. These findings were then correlated with histopathology. Study of normal infant bone clarifies the 3-D morphology of the subperiosteal bone collar (SPBC) and the radiographic zone of provisional calcification (ZPC). Studies on specimens with CML confirm that this lesion is a fracture extending in a planar fashion through the metaphysis, separating a mineralized fragment. This disk-like mineralized fragment has two components: (1) a thick peripheral component encompassing the SPBC; and (2) a thin central component comprised predominantly of the radiologic ZPC. By manipulating the 3-D model, the varying appearances of the CML are displayed. High-resolution CT coupled with histopathology provides elucidation of the morphology of the CML, a strong indicator of infant abuse. This new information may prove useful in assessing the biomechanical factors that produce this strong indicator of abusive assaults in infants. (orig.)

  5. Can Twitter Be a Source of Information on Allergy? Correlation of Pollen Counts with Tweets Reporting Symptoms of Allergic Rhinoconjunctivitis and Names of Antihistamine Drugs.

    Science.gov (United States)

    Gesualdo, Francesco; Stilo, Giovanni; D'Ambrosio, Angelo; Carloni, Emanuela; Pandolfi, Elisabetta; Velardi, Paola; Fiocchi, Alessandro; Tozzi, Alberto E

    2015-01-01

    Pollen forecasts are in use everywhere to inform therapeutic decisions for patients with allergic rhinoconjunctivitis (ARC). We exploited data derived from Twitter in order to identify tweets reporting a combination of symptoms consistent with a case definition of ARC and those reporting the name of an antihistamine drug. In order to increase the sensitivity of the system, we applied an algorithm aimed at automatically identifying jargon expressions related to medical terms. We compared weekly Twitter trends with National Allergy Bureau weekly pollen counts derived from US stations, and found a high correlation of the sum of the total pollen counts from each stations with tweets reporting ARC symptoms (Pearson's correlation coefficient: 0.95) and with tweets reporting antihistamine drug names (Pearson's correlation coefficient: 0.93). Longitude and latitude of the pollen stations affected the strength of the correlation. Twitter and other social networks may play a role in allergic disease surveillance and in signaling drug consumptions trends.

  6. Can Twitter Be a Source of Information on Allergy? Correlation of Pollen Counts with Tweets Reporting Symptoms of Allergic Rhinoconjunctivitis and Names of Antihistamine Drugs.

    Directory of Open Access Journals (Sweden)

    Francesco Gesualdo

    Full Text Available Pollen forecasts are in use everywhere to inform therapeutic decisions for patients with allergic rhinoconjunctivitis (ARC. We exploited data derived from Twitter in order to identify tweets reporting a combination of symptoms consistent with a case definition of ARC and those reporting the name of an antihistamine drug. In order to increase the sensitivity of the system, we applied an algorithm aimed at automatically identifying jargon expressions related to medical terms. We compared weekly Twitter trends with National Allergy Bureau weekly pollen counts derived from US stations, and found a high correlation of the sum of the total pollen counts from each stations with tweets reporting ARC symptoms (Pearson's correlation coefficient: 0.95 and with tweets reporting antihistamine drug names (Pearson's correlation coefficient: 0.93. Longitude and latitude of the pollen stations affected the strength of the correlation. Twitter and other social networks may play a role in allergic disease surveillance and in signaling drug consumptions trends.

  7. Inverse correlation between quasiparticle mass and T c in a cuprate high-T c superconductor.

    Science.gov (United States)

    Putzke, Carsten; Malone, Liam; Badoux, Sven; Vignolle, Baptiste; Vignolles, David; Tabis, Wojciech; Walmsley, Philip; Bird, Matthew; Hussey, Nigel E; Proust, Cyril; Carrington, Antony

    2016-03-01

    Close to a zero-temperature transition between ordered and disordered electronic phases, quantum fluctuations can lead to a strong enhancement of electron mass and to the emergence of competing phases such as superconductivity. A correlation between the existence of such a quantum phase transition and superconductivity is quite well established in some heavy fermion and iron-based superconductors, and there have been suggestions that high-temperature superconductivity in copper-oxide materials (cuprates) may also be driven by the same mechanism. Close to optimal doping, where the superconducting transition temperature T c is maximal in cuprates, two different phases are known to compete with superconductivity: a poorly understood pseudogap phase and a charge-ordered phase. Recent experiments have shown a strong increase in quasiparticle mass m* in the cuprate YBa2Cu3O7-δ as optimal doping is approached, suggesting that quantum fluctuations of the charge-ordered phase may be responsible for the high-T c superconductivity. We have tested the robustness of this correlation between m* and T c by performing quantum oscillation studies on the stoichiometric compound YBa2Cu4O8 under hydrostatic pressure. In contrast to the results for YBa2Cu3O7-δ, we find that in YBa2Cu4O8, the mass decreases as T c increases under pressure. This inverse correlation between m* and T c suggests that quantum fluctuations of the charge order enhance m* but do not enhance T c.

  8. High Degree Cubature Federated Filter for Multisensor Information Fusion with Correlated Noises

    Directory of Open Access Journals (Sweden)

    Lijun Wang

    2016-01-01

    Full Text Available This paper proposes an improved high degree cubature federated filter for the nonlinear fusion system with cross-correlation between process and measurement noises at the same time using the fifth-degree cubature rule and the decorrelated principle in its local filters. The master filter of the federated filter adopts the no-reset mode to fuse local estimates of local filters to generate a global estimate according to the scalar weighted rule. The air-traffic maneuvering target tracking simulations are performed between the proposed filter and the fifth-degree cubature federated filter. Simulations results demonstrate that the proposed filter not only can achieve almost the same accuracy as the fifth-degree cubature federated filter with independent white noises, but also has superior performance to the fifth-degree cubature federated filter while the noises are cross-correlated at the same time.

  9. High chondroitin sulfate proteoglycan 4 expression correlates with poor outcome in patients with breast cancer.

    Science.gov (United States)

    Hsu, Nicholas C; Nien, Pei-Yung; Yokoyama, Kazunari K; Chu, Pei-Yi; Hou, Ming-Feng

    2013-11-15

    Chondroitin sulfate proteoglycan 4 (CSPG4), a transmembrane proteoglycan originally identified in melanoma cells, has been reported to be expressed in breast cancer cells. This study was performed to examine the expression and significance of CSPG4 in a cohort of breast cancer patients. Immunohistochemical analysis of CSPG4 was performed on tissue microarrays constructed from tissue specimens from 240 breast cancer patients. CSPG4 staining was correlated with clinical and pathological characteristics, overall survival (OS), and disease recurrence. Contradicting to a previous report, our results showed that high CSPG4 expression was not related to triple-negative status of breast cancer patients. The Kaplan-Meier method showed that high CSPG4 expression was significantly associated with shorter time to recurrence (TTR). Patients with high CSPG4 expression had poorer OS and shorter TTR in a multivariate survival analysis after adjustment for stage, tumor grade, expression of estrogen receptor and progesterone receptor, and HER2 overexpression. This study showed that high CSPG4 expression correlates with disease recurrence and OS in breast cancers.

  10. The dynamic behaviors of complementary correlations under decoherence channels

    Science.gov (United States)

    Du, Ming-Ming; Wang, Dong; Ye, Liu

    2017-01-01

    Complementary correlations can reveal the genuine quantum correlations present in a composite quantum system. Here, we explore an effective method to identify the entangled Bell diagonal states by means of Pearson correlation, one of the complementary correlations. Then, we extend this method to expose the dynamic behavior of complementary correlations under various kinds of decoherence channels. The sudden death and revival of entanglement can be explained by the idea of Pearson correlation. The threshold that is used to identify entanglement is proposed. Furthermore, we put forward a new method to expound the underlying physical mechanisms for which classical and quantum correlations suffer a sudden change in the decoherence process.

  11. High daily doses of benzodiazepines among Quebec seniors: prevalence and correlates

    Directory of Open Access Journals (Sweden)

    Moride Yola

    2001-11-01

    Full Text Available Abstract Background Use of high daily doses of benzodiazepines is generally contraindicated for seniors. While both patient and physician factors may influence the use of high daily doses, previous research on the effect of patient factors has been extremely limited. The objectives of this study were to determine the one year prevalence of use of high daily doses of benzodiazepines, and examine physician and patient correlates of such use among Quebec community-dwelling seniors. Methods Patient information for 1423 community-dwelling Quebec seniors who participated in the Canadian Study of Health and Aging was linked to provincial health insurance administrative data bases containing detailed information on prescriptions received and prescribers. Results The standardized one year period prevalence of use of high daily doses of benzodiazepines was 7.9%. Use of high daily doses was more frequent among younger seniors and those who had reported anxiety during the previous year. Patients without cognitive impairment were more likely to receive high dose prescriptions from general practitioners, while those with cognitive impairment were more likely to receive high dose prescriptions from specialists. Conclusion High dose prescribing appears to be related to both patient and physician factors.

  12. Distribution and correlates of non-high-density lipoprotein cholesterol and triglycerides in Lebanese school children.

    Science.gov (United States)

    Gannagé-Yared, Marie-Hélène; Farah, Vanessa; Chahine, Elise; Balech, Nicole; Ibrahim, Toni; Asmar, Nadia; Barakett-Hamadé, Vanda; Jambart, Selim

    2016-01-01

    The prevalence of dyslipidelmia in pediatric Middle-Eastern populations is unknown. Our study aims to investigate the distribution and correlates of non-high-density lipoprotein cholesterol (non-HDL-C) and triglycerides among Lebanese school children. A total of 969 subjects aged 8-18 years were included in the study (505 boys and 464 girls). Recruitment was done from 10 schools located in the Great Beirut and Mount-Lebanon areas. Non-fasting total cholesterol, triglycerides, and HDL-cholesterol (HDL-C) were measured. Non-HDL-C was calculated. Schools were categorized into 3 socioeconomic statuses (SESs; low, middle, and high). In the overall population, the prevalence of high non-HDL-C (>3.8 mmol/L), very high non-HDL-C (>4.9 mmol/L), and high triglycerides (>1.5 mmol/l) are respectively 9.2%, 1.24%, and 26.6%. There is no significant gender difference for non-HDL-C or triglycerides. Non-HDL-C and triglycerides are inversely correlated with age in girls (P triglycerides are higher in children from lower SES schools. After adjustment for age and body mass index (BMI), testosterone is inversely associated with triglycerides in boys (P triglycerides are independently associated with BMI and schools' SES in both girls and boys. This study confirms, in our population, the association between obesity and both high non-HDL-C and triglycerides, and between high triglycerides and low SES. Copyright © 2016 National Lipid Association. Published by Elsevier Inc. All rights reserved.

  13. A novel mitochondrial DNA deletion in a patient with Pearson syndrome and neonatal diabetes mellitus provides insight into disease etiology, severity and progression.

    Science.gov (United States)

    Chen, Xin-Yu; Zhao, Si-Yu; Wang, Yan; Wang, Dong; Dong, Chang-Hu; Yang, Ying; Wang, Zhi-Hua; Wu, Yuan-Ming

    2016-07-01

    Pearson syndrome (PS) is a rare, mitochondrial DNA (mtDNA) deletion disorder mainly affecting hematopoietic system and exocrine pancreas in early infancy, which is characterized by multi-organ involvement, variable manifestations and poor prognosis. Since the clinical complexity and uncertain outcome of PS, the ability to early diagnose and anticipate disease progression is of great clinical importance. We described a patient with severe anemia and hyperglycinemia at birth was diagnosed with neonatal diabetes mellitus, and later with PS. Genetic testing revealed that a novel mtDNA deletion existed in various non-invasive tissues from the patient. The disease course was monitored by mtDNA deletion heteroplasmy and mtDNA/nucleus DNA genome ratio in different tissues and at different time points, showing a potential genotype-phenotype correlation. Our findings suggest that for patient suspected for PS, it may be therapeutically important to first perform detailed mtDNA analysis on non-invasive tissues at the initial diagnosis and during disease progression.

  14. Herschel-ATLAS: The Angular Correlation Function of Submillimetre Galaxies at High and Low Redshift

    Science.gov (United States)

    Maddox, S. J.; Dunne, L.; Rigby, E.; Eales, S.; Cooray, A.; Scott, D.; Peacock, J. A.; Negrello, M.; Smith, D. J. B.; Benford, D.; Amblard, A.; Auld, R.; Baes, M.; Bonfield, D.; Burgarella, D.; Buttiglione, S.; Cava, A.; Clements, D.; Dariush, A.; deZotti, G.; Dye, S.; Frayer, D.; Fritz, J.; Gonzalez-Nuevo, J.; Herranz, D.

    2010-01-01

    We present measurements of the angular correlation function of galaxies selected from the first field of the H-ATLAS survey. Careful removal of the background from galactic cirrus is essential, and currently dominates the uncertainty in our measurements. For our 250 micrometer-selected sample we detect no significant clustering, consistent with the expectation that the 250 pm-selected sources are mostly normal galaxies at z < or equal to 1. For our 350 micrometer and 500 micrometer-selected samples we detect relatively strong clustering with correlation amplitudes A of 0.2 and 1.2 at 1', but with relatively large uncertainties. For samples which preferentially select high redshift galaxies at z approx. 2-3 we detect significant strong clustering, leading to an estimate of r(0) approx. 7-11/h Mpc. The slope of our clustering measurements is very steep. delta approx. 2. The measurements are consistent with the idea that sub-mm sources consist of a low redshift population of normal galaxies and a high redshift population of highly clustered star-bursting galaxies.

  15. Predicting freeboard heat transfer by using empirical correlations in high temperature fluidized beds

    Energy Technology Data Exchange (ETDEWEB)

    Biyikli, Suleyman [Okan University Tuzla Kampusu, Faculty of Engineering and Architecture (Turkey)], email: suleyman.biyikli@okan.edu.tr

    2011-07-01

    This article investigates the heat transfer characteristics for horizontal tubes in a freeboard region of high temperature fluidized beds. The freeboard entrainment heights are calculated by using empirical correlations described in detail and used in estimating the heat transfer coefficients from a horizontal tube occurring by radiation, gas convection, and particle contact mechanisms in high temperature a fluidized bed combustor. The total average of these coefficients around a horizontal tube carrying water in high temperature fluidized beds can be written as the sum of convective, radiative, and fluidized-particle contact heat transfer coefficients and these correlations are tested against certain published experimental measurements. In full agreement with this data, it was observed that the calculated heat transfer coefficients increased with increasing gas velocity at a given tube elevation and they decreased and approached the values of single-phase gas convection and radiation with increasing tube elevation in the freeboard region while the relative contribution of radiation increases and approaches a constant fraction of total heat transfer.

  16. Mental retardation in mucopolysaccharidoses correlates with high molecular weight urinary heparan sulphate derived glucosamine.

    Science.gov (United States)

    Coppa, G V; Gabrielli, O; Zampini, L; Maccari, F; Mantovani, V; Galeazzi, T; Santoro, L; Padella, L; Marchesiello, R L; Galeotti, F; Volpi, N

    2015-12-01

    Mucopolysaccharidoses (MPS) are characterized by mental retardation constantly present in the severe forms of Hurler (MPS I), Hunter (MPS II) and Sanfilippo (MPS III) diseases. On the contrary, mental retardation is absent in Morquio (MPS IV) and Maroteaux-Lamy (MPS VI) diseases and absent or only minimal in the attenuated forms of MPS I, II and III. Considering that MPS patients affected by mental disease accumulate heparan sulfate (HS) due to specific enzymatic defects, we hypothesized a possible correlation between urinary HS-derived glucosamine (GlcN) accumulated in tissues and excreted in biological fluids and mental retardation. 83 healthy subjects were found to excrete HS in the form of fragments due to the activity of catabolic enzymes that are absent or impaired in MPS patients. On the contrary, urinary HS in 44 patients was observed to be composed of high molecular weight polymer and fragments of various lengths depending on MPS types. On this basis we correlated mental retardation with GlcN belonging to high and low molecular weight HS. We demonstrate a positive relationship between the accumulation of high molecular weight HS and mental retardation in MPS severe compared to attenuated forms. This is also supported by the consideration that accumulation of other GAGs different from HS, as in MPS IV and MPS VI, and low molecular weight HS fragments do not impact on central nervous system disease.

  17. Meta-Analysis of Correlations Between Marginal Bone Resorption and High Insertion Torque of Dental Implants.

    Science.gov (United States)

    Li, Haoyan; Liang, Yongqiang; Zheng, Qiang

    2015-01-01

    To evaluate correlations between marginal bone resorption and high insertion torque value (> 50 Ncm) of dental implants and to assess the significance of immediate and early/conventional loading of implants under a certain range torque value. Specific inclusion and exclusion criteria were used to retrieve eligible articles from Ovid, PubMed, and EBSCO up to December 2013. Screening of eligible studies, quality assessment, and data extraction were conducted in duplicate. The results were expressed as random/fixed-effects models using weighted mean differences for continuous outcomes with 95% confidence intervals. Initially, 154 articles were selected (11 from Ovid, 112 from PubMed, and 31 from EBSCO). After exclusion of duplicate articles and articles that did not meet the inclusion criteria, six clinical studies were selected. Assessment of P values revealed that correlations between marginal bone resorption and high insertion torque were not statistically significant and that there was no difference between immediately versus early/conventionally loaded implants under a certain range of torque. None of the meta-analyses revealed any statistically significant differences between high insertion torque and conventional insertion torque in terms of effects on marginal bone resorption.

  18. High avidity antibodies to full-length VAR2CSA correlate with absence of placental malaria.

    Directory of Open Access Journals (Sweden)

    Yeung Lo Tutterrow

    Full Text Available VAR2CSA mediates sequestration of Plasmodium falciparum-infected erythrocytes in the placenta, increasing the risk of poor pregnancy outcomes. Naturally acquired antibodies (Ab to placental parasites at delivery have been associated with improved pregnancy outcomes, but Ab levels and how early in pregnancy Ab must be present in order to eliminate placental parasites before delivery remains unknown. Antibodies to individual Duffy-binding like domains of VAR2CSA have been studied, but the domains lack many of the conformational epitopes present in full-length VAR2CSA (FV2. Thus, the purpose of this study was to describe the acquisition of Ab to FV2 in women residing in high and low transmission areas and determine how Ab levels during pregnancy correlate with clearance of placental parasites. Plasma samples collected monthly throughout pregnancy from pregnant women living in high and low transmission areas in Cameroon were evaluated for Ab to FV2 and the proportion of high avidity Ab (i.e., Ab that remain bound in the presence of 3M NH(4SCN was assessed. Ab levels and proportion of high avidity Ab were compared between women with placental malaria (PM(+ and those without (PM(- at delivery. Results showed that PM(- women had significantly higher Ab levels (p = 0.0047 and proportion of high avidity Ab (p = 0.0009 than PM(+ women throughout pregnancy. Specifically, women with moderate to high Ab levels (>5,000 MFI and those with ≥ 35% high avidity Ab at 5-6 months were found to have 2.3 (95% CI, 1.0-4.9 and 7.6-fold (p = 0.0013, 95% CI: 1.2-50.0 reduced risk of placental malaria, respectively. These data show that high levels of Ab to FV2, particularly those with high avidity for FV2, produced by mid-pregnancy are important in clearing parasites from the placenta. Both high Ab levels and proportion of high avidity Ab to FV2 may serve as correlates of protection for assessing immunity against placental malaria.

  19. Long range rapidity correlations and jet production in high energy nuclear collisions

    Energy Technology Data Exchange (ETDEWEB)

    STAR Collaboration; Abelev, Betty

    2010-07-05

    The STAR Collaboration at RHIC presents a systematic study of high transverse momentum charged di-hadron correlations at small azimuthal pair separation {Delta}{phi}, in d+Au and central Au+Au collisions at {radical}s{sub NN} = 200 GeV. Significant correlated yield for pairs with large longitudinal separation {Delta}{eta} is observed in central Au+Au, in contrast to d+Au collisions. The associated yield distribution in {Delta}{eta} x {delta}{phi} can be decomposed into a narrow jet-like peak at small angular separation which has a similar shape to that found in d+Au collisions, and a component which is narrow in {Delta}{phi} and depends only weakly on {Delta}{eta}, the 'ridge'. Using two systematically independent analyses, finite ridge yield is found to persist for trigger p{sub t} > 6 GeV/c, indicating that it is correlated with jet production. The transverse momentum spectrum of hadrons comprising the ridge is found to be similar to that of bulk particle production in the measured range (2 < p{sub t} < 4 GeV/c).

  20. Correlation between the High Density Lipoprotein and its Subtypes in Coronary Heart Disease

    Directory of Open Access Journals (Sweden)

    Fen Gao

    2016-05-01

    Full Text Available Background/Aims: To detect the changes of high density lipoprotein (HDL and its subtypes in serum of patients with coronary heart disease (CHD. Methods: 337 hospitalized patients were selected from our hospital during August, 2014 - January, 2015, and divided into CHD group (n = 190 and control group (n = 127. Lipoprint lipoprotein analyzer was used to classify low density lipoprotein (LDL particle size and its sub-components, as well as HDL particle size and its sub-components. The changes of the subtypes in patients with CHD were statistically analyzed. The possible mechanism was explored. Results: (1 Compared with the control group, the concentration of HDL in CHD patients reduced, HDLL significantly decreased (P S increased (P L had the most significant decreased; (3 HDL and all HDL subtypes were positively correlated with apolipoprotein A-I (apoA-I, of which, HDLL had the biggest correlation with apoA-I (P M had a maximum correlation with HDL (P Conclusion: HDL maturation disorders existed in the serum of CHD patients, HDLL may be protected factor for CHD, whose decrease was closely related wit the risk increase of CHD. The cardiovascular protection function of HDLL may be related with apoA-I content.

  1. Similarity in recombination rate estimates highly correlates with genetic differentiation in humans.

    Directory of Open Access Journals (Sweden)

    Hafid Laayouni

    Full Text Available Recombination varies greatly among species, as illustrated by the poor conservation of the recombination landscape between humans and chimpanzees. Thus, shorter evolutionary time frames are needed to understand the evolution of recombination. Here, we analyze its recent evolution in humans. We calculated the recombination rates between adjacent pairs of 636,933 common single-nucleotide polymorphism loci in 28 worldwide human populations and analyzed them in relation to genetic distances between populations. We found a strong and highly significant correlation between similarity in the recombination rates corrected for effective population size and genetic differentiation between populations. This correlation is observed at the genome-wide level, but also for each chromosome and when genetic distances and recombination similarities are calculated independently from different parts of the genome. Moreover, and more relevant, this relationship is robustly maintained when considering presence/absence of recombination hotspots. Simulations show that this correlation cannot be explained by biases in the inference of recombination rates caused by haplotype sharing among similar populations. This result indicates a rapid pace of evolution of recombination, within the time span of differentiation of modern humans.

  2. Neural correlates of heterotopic facilitation induced after high frequency electrical stimulation of nociceptive pathways

    Directory of Open Access Journals (Sweden)

    van Rijn Clementina M

    2011-04-01

    Full Text Available Abstract Background High frequency electrical stimulation (HFS of primary nociceptive afferents in humans induce a heightened sensitivity in the surrounding non-stimulated skin area. Several studies suggest that this heterotopic effect is the result of central (spinal plasticity. The aim of this study is to investigate HFS-induced central plasticity of sensory processing at the level of the brain using the electroencephalogram (EEG. To this end we measured evoked potentials in response to noxious electrical pinprick-like stimuli applied in the heterotopic skin area before, directly after and 30 minutes after HFS. Results We observed potential cortical electrophysiological correlates of heterotopic facilitation. Two different cortical correlates were found; the first one was a lateralized effect, i.e. a larger N100 amplitude on the conditioned arm than the control arm 30 minutes after end of HFS. This was comparable with the observed lateralized effect of visual analogue scale (VAS scores as response to the mechanical punctate stimuli. The second correlate seems to be a more general (non-lateralized effect, because the result affects both arms. On average for both arms the P200 amplitude increased significantly 30 minutes after end of HFS with respect to baseline. Conclusions We suggest that for studying heterotopic nociceptive facilitation the evoked brain response is suitable and relevant for investigating plasticity at the level of the brain and is perhaps a more sensitive and reliable marker than the perceived pain intensity (e.g. VAS.

  3. Pairing in high-density neutron matter including short- and long-range correlations

    CERN Document Server

    Ding, D; Dickhoff, W H; Dussan, H; Polls, A; Witte, S J

    2015-01-01

    The influence of short-range correlations (SRC) on the spectral distribution of neutrons is incorporated in the solution of the gap equation for the ${}^3P_2-{}^3F_2$ coupled channel in pure neutron matter at high density. This effect is studied for three different realistic interactions. The gap in this channel is strongly suppressed by these correlations but does not vanish. For a consistent treatment we also include for the first time the effect of long-range correlations (LRC) by incorporating polarization terms in addition to the bare interaction. This allows the neutrons to exchange density and spin fluctuations governed by the strength of Landau parameters with values that are consistent with the available literature. While these LRC have an antiscreening tendency, they only slightly increase the gap in the ${}^3P_2-{}^3F_2$ coupled channel for all three realistic interactions as long as SRC are included. All three interactions generate maximum gaps around 0.1 to 0.2 MeV at most with a small dependence...

  4. High-resolution computed tomography in silicosis: correlation with chest radiography and pulmonary function tests

    Energy Technology Data Exchange (ETDEWEB)

    Lopes, Agnaldo Jose [Universidade do Estado do Rio de Janeiro (UERJ), RJ (Brazil). Pedro Ernesto Univ. Hospital. Dept. of Respiratory Function]. E-mail: phel.lop@uol.com.br; Mogami, Roberto; Capone, Domenico; Jansen, Jose Manoel [Universidade do Estado do Rio de Janeiro (UERJ), RJ (Brazil). School of Medical Sciences; Tessarollo, Bernardo [Universidade do Estado do Rio de Janeiro (UERJ), RJ (Brazil). Dept. of Radiology and Diagnostic Image; Melo, Pedro Lopes de [Universidade do Estado do Rio de Janeiro (UERJ), RJ (Brazil). Inst. of Biology

    2008-05-15

    Objective: To correlate tomographic findings with pulmonary function findings, as well as to compare chest X-ray findings with high-resolution computed tomography (HRCT) findings, in patients with silicosis. Methods: A cross-sectional study was conducted in 44 non-smoking patients without a history of tuberculosis. Chest X-ray findings were classified according to the International Labour Organization recommendations. Using a semiquantitative system, the following HRCT findings were measured: the full extent of pulmonary involvement; parenchymal opacities; and emphysema. Spirometry and forced oscillation were performed. Pulmonary volumes were evaluated using the helium dilution method, and diffusing capacity of the lung for carbon monoxide was assessed. Results: Of the 44 patients studied, 41 were male. The mean age was 48.4 years. There were 4 patients who were classified as category 0 based on X-ray findings and as category 1 based on HRCT findings. Using HRCT scans, we identified progressive massive fibrosis in 33 patients, compared with only 23 patients when X-rays were used. Opacity score was found to correlate most closely with airflow, DLCO and compliance. Emphysema score correlated inversely with volume, DLCO and airflow. In this sample of patients presenting a predominance of large opacities (75% of the individuals), the deterioration of pulmonary function was associated with the extent of structural changes. Conclusions: In the early detection of silicosis and the identification of progressive massive fibrosis, HRCT scans are superior to X-rays. (author)

  5. High Frequency Sampling of TTL Pulses on a Raspberry Pi for Diffuse Correlation Spectroscopy Applications.

    Science.gov (United States)

    Tivnan, Matthew; Gurjar, Rajan; Wolf, David E; Vishwanath, Karthik

    2015-08-12

    Diffuse Correlation Spectroscopy (DCS) is a well-established optical technique that has been used for non-invasive measurement of blood flow in tissues. Instrumentation for DCS includes a correlation device that computes the temporal intensity autocorrelation of a coherent laser source after it has undergone diffuse scattering through a turbid medium. Typically, the signal acquisition and its autocorrelation are performed by a correlation board. These boards have dedicated hardware to acquire and compute intensity autocorrelations of rapidly varying input signal and usually are quite expensive. Here we show that a Raspberry Pi minicomputer can acquire and store a rapidly varying time-signal with high fidelity. We show that this signal collected by a Raspberry Pi device can be processed numerically to yield intensity autocorrelations well suited for DCS applications. DCS measurements made using the Raspberry Pi device were compared to those acquired using a commercial hardware autocorrelation board to investigate the stability, performance, and accuracy of the data acquired in controlled experiments. This paper represents a first step toward lowering the instrumentation cost of a DCS system and may offer the potential to make DCS become more widely used in biomedical applications.

  6. High Frequency Sampling of TTL Pulses on a Raspberry Pi for Diffuse Correlation Spectroscopy Applications

    Directory of Open Access Journals (Sweden)

    Matthew Tivnan

    2015-08-01

    Full Text Available Diffuse Correlation Spectroscopy (DCS is a well-established optical technique that has been used for non-invasive measurement of blood flow in tissues. Instrumentation for DCS includes a correlation device that computes the temporal intensity autocorrelation of a coherent laser source after it has undergone diffuse scattering through a turbid medium. Typically, the signal acquisition and its autocorrelation are performed by a correlation board. These boards have dedicated hardware to acquire and compute intensity autocorrelations of rapidly varying input signal and usually are quite expensive. Here we show that a Raspberry Pi minicomputer can acquire and store a rapidly varying time-signal with high fidelity. We show that this signal collected by a Raspberry Pi device can be processed numerically to yield intensity autocorrelations well suited for DCS applications. DCS measurements made using the Raspberry Pi device were compared to those acquired using a commercial hardware autocorrelation board to investigate the stability, performance, and accuracy of the data acquired in controlled experiments. This paper represents a first step toward lowering the instrumentation cost of a DCS system and may offer the potential to make DCS become more widely used in biomedical applications.

  7. Correlation of doppler studies at 34 weeks of gestation with perinatal outcome in high risk pregnancies

    Directory of Open Access Journals (Sweden)

    Apoorva Reddy

    2015-12-01

    Results: Uterine artery S/D abnormality was seen in 32.5% of high risk cases were as abnormal umbilical artery S/D was seen in 25% and abnormal Pulsatility Index (PI in 15% cases. Middle cerebral artery flow was abnormal in only 17.5% cases. Abnormality in the uterine artery flow correlated well with the incidence of preterm delivery (69.2%, need for cesarean section (53.8% and length of Neonatal intensive care unit(NICU stay >48 hours (69.23%. Abnormal umbilical artery flow was associated with a significant increase in the incidence of preterm delivery(75%, small for gestational age babies(93.75% and length of NICU stay >48 hours (93.75%. There was no significant correlation seen with isolated abnormal middle cerebral artery flow. Conclusions: Both uterine and umbilical artery Doppler velocities correlate well with the perinatal outcome but abnormal uterine artery Doppler predicts adverse neonatal outcome better than the fetal vessels as it discriminates fetuses at risk because of abnormal placental vascularisation from those who are at risk due to other causes. [Int J Reprod Contracept Obstet Gynecol 2015; 4(6.000: 1894-1899

  8. Damage correlations in semiconductor devices exposed to gamma and high energy swift heavy ions

    Science.gov (United States)

    Pushpa, N.; Prakash, A. P. Gnana

    2015-05-01

    NPN rf power transistors and N-channel depletion MOSFETs are irradiated by different high energy swift heavy ions and 60Co gamma radiation in the dose range of 100 krad to 100 Mrad. The damage created by different heavy ions and 60Co gamma radiation in NPN rf power transistors and N-channel depletion MOSFETs have been correlated and studied in the same dose range. The recoveries in the electrical characteristics of different swift heavy ions and 60Co gamma irradiated devices have been studied after annihilation.

  9. Study of Isospin Correlation in High Energy Heavy Ion Interactions with the RHIC PHENIX. Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Takahashi, Y.

    2003-06-08

    This report describes the research work performed under the support of the DOE research grant E-FG02-97ER4108. The work is composed of three parts: (1) Visual analysis and quality control of the Micro Vertex Detector (MVD) of the PHENIX experiments carried out of Brookhaven National Laboratory. (2) Continuation of the data analysis of the EMU05/09/16 experiments for the study of the inclusive particle production spectra and multi-particle correlation. (3) Exploration of a new statistical means to study very high-multiplicity of nuclear-particle ensembles and its perspectives to apply to the higher energy experiments.

  10. Treating jet correlations in high pile-up at hadron colliders

    Directory of Open Access Journals (Sweden)

    F. Hautmann

    2016-03-01

    Full Text Available Experiments in the high-luminosity runs at the Large Hadron Collider face the challenges of very large pile-up. Primary techniques to deal with this are based on precise vertex and track reconstruction. Outside tracker acceptances, however, lie regions of interest for many aspects of the LHC physics program. We explore complementary approaches to pile-up treatment and propose a data-driven jet-mixing method which can be used outside tracker acceptances without depending on Monte Carlo generators. The method can be applied to treat correlation observables and take into account, besides the jet transverse momentum pedestal, effects of hard jets from pile-up.

  11. High-Frequency Color Doppler Sonography of Bullous Pemphigoid: Correlation With Histologic Findings.

    Science.gov (United States)

    Porriño-Bustamante, María Librada; Alfageme, Fernando; Suárez, Lola; de Domingo, María Antonia González; Hospital, Mercedes; Roustán, Gastón

    2016-08-01

    Bullous pemphigoid is the most frequent autoimmune-mediated blistering skin disease, belonging to the group of subepidermal bullae. We performed high-frequency color Doppler sonography in 3 cases of bullous pemphigoid, in bullous and adjacent non-bullous skin, which showed homogeneous sonographic findings. Subepidermal cystic structures with dermal hypoechogenicity were observed in bullous skin. In nonbullous skin, the dermis showed hypoechogenicity compared to normal skin. Color Doppler signals were increased in both areas. These findings correlate histologically with subepidermal bullae and dermal inflammatory infiltrates.

  12. High-speed optical correlation-domain reflectometry without using acousto-optic modulator

    CERN Document Server

    Shizuka, Makoto; Hayashi, Neisei; Mizuno, Yosuke; Nakamura, Kentaro

    2015-01-01

    To achieve a distributed reflectivity measurement along an optical fiber, we develop a simplified cost-effective configuration of optical correlation- (or coherence-) domain reflectometry based on a synthesized optical coherence function by sinusoidal modulation. By excluding conventional optical heterodyne detection (practically, without using an acousto-optic modulator) and by exploiting the foot of the Fresnel reflection spectrum, the electrical bandwidth required for signal processing is lowered down to several megahertz. We evaluate the basic system performance and demonstrate its high-speed operation (10 ms for one scan) by tracking a moving reflection point in real time.

  13. THE ROWWISE CORRELATION BETWEEN 2 PROXIMITY MATRICES AND THE PARTIAL ROWWISE CORRELATION

    NARCIS (Netherlands)

    de Vries, Han

    1993-01-01

    This paper discusses rowwise matrix correlation, based on the weighted sum of correlations between all pairs of corresponding rows of two proximity matrices, which may both be square (symmetric or asymmetric) or rectangular. Using the correlation coefficients usually associated with Pearson, Spearma

  14. THE ROWWISE CORRELATION BETWEEN 2 PROXIMITY MATRICES AND THE PARTIAL ROWWISE CORRELATION

    NARCIS (Netherlands)

    de Vries, Han

    This paper discusses rowwise matrix correlation, based on the weighted sum of correlations between all pairs of corresponding rows of two proximity matrices, which may both be square (symmetric or asymmetric) or rectangular. Using the correlation coefficients usually associated with Pearson,

  15. ICE-Based Custom Full-Mesh Network for the CHIME High Bandwidth Radio Astronomy Correlator

    Science.gov (United States)

    Bandura, K.; Cliche, J. F.; Dobbs, M. A.; Gilbert, A. J.; Ittah, D.; Mena Parra, J.; Smecher, G.

    New generation radio interferometers encode signals from thousands of antenna feeds across large bandwidth. Channelizing and correlating this data requires networking capabilities that can handle unprecedented data rates with reasonable cost. The Canadian Hydrogen Intensity Mapping Experiment (CHIME) correlator processes 8-bits from N=2,048 digitizer inputs across 400MHz of bandwidth. Measured in N2× bandwidth, it is the largest radio correlator that is currently commissioning. Its digital back-end must exchange and reorganize the 6.6terabit/s produced by its 128 digitizing and channelizing nodes, and feed it to the 256 graphics processing unit (GPU) node spatial correlator in a way that each node obtains data from all digitizer inputs but across a small fraction of the bandwidth (i.e. ‘corner-turn’). In order to maximize performance and reliability of the corner-turn system while minimizing cost, a custom networking solution has been implemented. The system makes use of Field Programmable Gate Array (FPGA) transceivers to implement direct, passive copper, full-mesh, high speed serial connections between sixteen circuit boards in a crate, to exchange data between crates, and to offload the data to a cluster of 256 GPU nodes using standard 10Gbit/s Ethernet links. The GPU nodes complete the corner-turn by combining data from all crates and then computing visibilities. Eye diagrams and frame error counters confirm error-free operation of the corner-turn network in both the currently operating CHIME Pathfinder telescope (a prototype for the full CHIME telescope) and a representative fraction of the full CHIME hardware providing an end-to-end system validation. An analysis of an equivalent corner-turn system built with Ethernet switches instead of custom passive data links is provided.

  16. Modelos de regressão simplex: resíduos de Pearson corrigidos e aplicações

    OpenAIRE

    Lucimary Afonso dos Santos

    2011-01-01

    A distribuição simplex, proposta por Barndor-Nielsen e Jørgensen (1991) é útil para a modelagem de dados contínuos no intervalo (0,1). Nesse trabalho, desenvolve-se o modelo de regressão simplex considerando-se ´ = h(X; ¯), sendo h(:; :) uma função arbitr ária. Denem-se os resíduos para o modelo considerado e obtêm-se correções assintóticas para resíduos do tipo Ri. A primeira correção proposta baseou-se na obtenção da expressão assintótica para a densidade dos resíduos de Pearson, corrigidos...

  17. A high resolution laser ranging system based on time-correlated single-photon counting technology

    Science.gov (United States)

    Yang, Yixin; Wang, Huanqin; Huang, Zhe; Cao, Yangyang; Gui, Huaqiao

    2014-12-01

    Laser ranging has become an important method for both distance measurements and acquisition of threedimensional (3D) images. In this paper, a laser ranging system based on Time-Correlated Single-Photon Counting technology (TCSPC) is developed. A Geiger-mode avalanche photodiode (G-APD), which has the ability of detecting single-photon events, is used to capture the weak light scattered from the long-range target. In order to improve the ranging resolution of TCSPC based measurement system, a high repetition frequency of subnanosecond narrow pulse generator circuit based on the avalanche effect of RF-BJT is designed and applied as the light source. Moreover, some optimized optical light designs have been done to improve the system signal to noise rate (SNR), including using a special aspherical lens as projecting lens, adopting a telephoto camera lens with small view angle and short depth of field before detector. Experimental tests for evaluation of the laser raging system performance are described. As a means of echo signal analysis, three different algorithms have been introduced, in which the cross-correlation algorithm was demonstrated to be the most effective algorithm to determining the round trip time to a target, even based on histograms with a significant amount of background noise photons. It was found that centimeter ranging resolution can be achieved thanks to the use of Time-to-Digital Converter (TDC) with picosecond resolution and the Cross-Correlation algorithm. The proposed laser ranging system has advantages of high range resolution, short response time and simple structure, which was potential applications for 3D object recognition, computer vision, reverse engineering and virtual reality.

  18. High avidity antibodies to full-length VAR2CSA correlate with absence of placental malaria

    DEFF Research Database (Denmark)

    Tutterrow, Yeung Lo; Salanti, Ali; Avril, Marion;

    2012-01-01

    VAR2CSA mediates sequestration of Plasmodium falciparum-infected erythrocytes in the placenta, increasing the risk of poor pregnancy outcomes. Naturally acquired antibodies (Ab) to placental parasites at delivery have been associated with improved pregnancy outcomes, but Ab levels and how early...... in pregnancy Ab must be present in order to eliminate placental parasites before delivery remains unknown. Antibodies to individual Duffy-binding like domains of VAR2CSA have been studied, but the domains lack many of the conformational epitopes present in full-length VAR2CSA (FV2). Thus, the purpose...... of this study was to describe the acquisition of Ab to FV2 in women residing in high and low transmission areas and determine how Ab levels during pregnancy correlate with clearance of placental parasites. Plasma samples collected monthly throughout pregnancy from pregnant women living in high and low...

  19. High-resolution MR imaging of the cutis and subcutis. Histological correlation

    Energy Technology Data Exchange (ETDEWEB)

    Krug, B.; Kugel, H.; Krahe, T.; Lackner, K. [Koeln Univ. (Germany). Radiologisches Inst. und Poliklinik; Schulze, H.J. [Koeln Univ. (Germany). Klinik und Poliklinik fuer Dermatologie und Venerologie; Gieseke, J. [Philips Medical Systems, Hamburg (Germany)

    1998-09-01

    Objective: To determine whether the spatial resolution that can be achieved with currently available MR devices is adequate for the evaluation of skin disease. Material and Methods: We correlated high-resolution MR images of the skin with dermatohistopathology in 26 patients. The examinations were carried out on a 1.0 T imager using a commercially available surface coil (ID 7.5 cm) and optimized SE and GE sequences. Image quality was assessed by four readers on a questionnaire. Results: The visualization of the dermis, subcutaneous tissue, and muscle fascia allowed a pattern analysis that gave findings identical to those at dermatohistopathology. It was possible to distinguish septal from lobular panniculitis, and lipatrophia from sclerodermia. Images with contrast media infusion were useful in the differential diagnosis. Conclusion: High-resolution MR imaging may narrow down the differential diagnosis of various skin diseases and may help to reduce the number of skin biopsies on certain indications. (orig.)

  20. Heat transfer correlation for high-finned tubes in staggered arrangement; High fin tube chidori hairetsu no netsudentatsuritsu seirishiki ni tsuite

    Energy Technology Data Exchange (ETDEWEB)

    Hashizume, K. [Hiroshima Institute of Technology, Hiroshima (Japan)

    1995-07-25

    Existing correlations are reviewed for heat transfer of high-finned tubes in staggered arrangement, and compared with published experimental data. These data include those using tubes for air-coolers (AC) and for heat recovery heat exchangers in the high-temperature region (HRHX). Comparisons showed that none of the correlations can predict experimental data for both AC and for HRHX. Therefore, a new correlation is proposed which can predict almost all data within 10%. 5 refs., 6 figs., 3 tabs.

  1. VOLUME STUDY WITH HIGH DENSITY OF PARTICLES BASED ON CONTOUR AND CORRELATION IMAGE ANALYSIS

    Directory of Open Access Journals (Sweden)

    Tatyana Yu. Nikolaeva

    2014-11-01

    Full Text Available The subject of study is the techniques of particle statistics evaluation, in particular, processing methods of particle images obtained by coherent illumination. This paper considers the problem of recognition and statistical accounting for individual images of small scattering particles in an arbitrary section of the volume in case of high concentrations. For automatic recognition of focused particles images, a special algorithm for statistical analysis based on contouring and thresholding was used. By means of the mathematical formalism of the scalar diffraction theory, coherent images of the particles formed by the optical system with high numerical aperture were simulated. Numerical testing of the method proposed for the cases of different concentrations and distributions of particles in the volume was performed. As a result, distributions of density and mass fraction of the particles were obtained, and the efficiency of the method in case of different concentrations of particles was evaluated. At high concentrations, the effect of coherent superposition of the particles from the adjacent planes strengthens, which makes it difficult to recognize images of particles using the algorithm considered in the paper. In this case, we propose to supplement the method with calculating the cross-correlation function of particle images from adjacent segments of the volume, and evaluating the ratio between the height of the correlation peak and the height of the function pedestal in the case of different distribution characters. The method of statistical accounting of particles considered in this paper is of practical importance in the study of volume with particles of different nature, for example, in problems of biology and oceanography. Effective work in the regime of high concentrations expands the limits of applicability of these methods for practically important cases and helps to optimize determination time of the distribution character and

  2. Correlating and predicting psychiatric symptom ratings: Spearman's r versus Kendall's tau correlation.

    Science.gov (United States)

    Arndt, S; Turvey, C; Andreasen, N C

    1999-01-01

    Simple correlations play a large role in the analysis of psychiatric data. They are used to predict outcome, validate new instruments, establish treatment efficacy and find symptom patterns. Researchers and data analysts often face a question about which correlation coefficient to use in a study but are often unaware of the strengths and weaknesses of the alternative correlation measures. The presence of outliers, nonconstant variance, skewed distributions and unequal n are common in psychiatric data and this poses severe problems for many classic statistical methods. We compare Pearson, Spearman and Kendall's correlation coefficients using a large sample of subjects with schizophrenia spectrum disorders who were evaluated with 7 different psychiatric rating scales. Samples sizes ranging from 8 to 50 were evaluated using bootstrapping methods. The criteria for evaluation of the correlations were the type I error rates, power, bias and confidence interval width. Pearson's r did not always control for false positives at the nominal rate and was often unstable. Spearman's r performed better than Pearson's but provided a biased estimate of the true correlation. Spearman's r was also difficult to interpret. Our results suggest that Kendall's tau(b) has many advantages over Pearson's and Spearman's r; when applied to psychiatric data, tau(b) maintained adequate control of type I errors, was nearly as powerful as Pearson's r, provided much tighter confidence intervals and had a clear interpretation.

  3. Discrete Pearson distributions

    Energy Technology Data Exchange (ETDEWEB)

    Bowman, K.O. [Oak Ridge National Lab., TN (United States); Shenton, L.R. [Georgia Univ., Athens, GA (United States); Kastenbaum, M.A. [Kastenbaum (M.A.), Basye, VA (United States)

    1991-11-01

    These distributions are generated by a first order recursive scheme which equates the ratio of successive probabilities to the ratio of two corresponding quadratics. The use of a linearized form of this model will produce equations in the unknowns matched by an appropriate set of moments (assumed to exist). Given the moments we may find valid solutions. These are two cases; (1) distributions defined on the non-negative integers (finite or infinite) and (2) distributions defined on negative integers as well. For (1), given the first four moments, it is possible to set this up as equations of finite or infinite degree in the probability of a zero occurrence, the sth component being a product of s ratios of linear forms in this probability in general. For (2) the equation for the zero probability is purely linear but may involve slowly converging series; here a particular case is the discrete normal. Regions of validity are being studied. 11 refs.

  4. High-latitude plasma convection from Cluster EDI: variances and solar wind correlations

    Directory of Open Access Journals (Sweden)

    M. Förster

    2007-07-01

    Full Text Available Based on drift velocity measurements of the EDI instruments on Cluster during the years 2001–2006, we have constructed a database of high-latitude ionospheric convection velocities and associated solar wind and magnetospheric activity parameters. In an earlier paper (Haaland et al., 2007, we have described the method, consisting of an improved technique for calculating the propagation delay between the chosen solar wind monitor (ACE and Earth's magnetosphere, filtering the data for periods of sufficiently stable IMF orientations, and mapping the EDI measurements from their high-altitude positions to ionospheric altitudes. The present paper extends this study, by looking at the spatial pattern of the variances of the convection velocities as a function of IMF orientation, and by performing sortings of the data according to the IMF magnitude in the GSM y-z plane, |ByzIMF|, the estimated reconnection electric field, Er,sw, the solar wind dynamic pressure, Pdyn, the season, and indices characterizing the ring current (Dst and tail activity (ASYM-H. The variability of the high-latitude convection shows characteristic spatial patterns, which are mirror symmetric between the Northern and Southern Hemispheres with respect to the IMF By component. The latitude range of the highest variability zone varies with IMF Bz similar to the auroral oval extent. The magnitude of convection standard deviations is of the same order as, or even larger than, the convection magnitude itself. Positive correlations of polar cap activity are found with |ByzIMF| and with Er,sw, in particular. The strict linear increase for small magnitudes of Er,sw starts to deviate toward a flattened increase above about 2 mV/m. There is also a weak positive correlation with Pdyn. At

  5. High Mobility Group Box Protein-1 correlates with renal function in chronic kidney disease (CKD).

    Science.gov (United States)

    Bruchfeld, Annette; Qureshi, Abdul Rashid; Lindholm, Bengt; Barany, Peter; Yang, Lihong; Stenvinkel, Peter; Tracey, Kevin J

    2008-01-01

    Chronic kidney disease (CKD) is associated with inflammation and malnutrition and carries a markedly increased risk of cardiovascular disease (CVD). High Mobility Group Box Protein-1 (HMGB-1) is a 30-kDa nuclear and cytosolic protein known as a transcription and growth factor, recently identified as a proinflammatory mediator of tissue injury. Recent data implicates HMGB-1 in endotoxin lethality, rheumatoid arthritis, and atherosclerosis. The aim of this post-hoc, cross-sectional study was to determine whether HMGB-1 serum levels are elevated in CKD patients. The study groups were categorized as follows: 110 patients starting dialysis defined as CKD 5; 67 patients with moderately to severely reduced renal function or CKD 3-4; and 48 healthy controls. High-sensitivity C-reactive-protein (hs-CRP), interleukin-6 (IL-6), tumor necrosis factor (TNF), serum-albumin (S-albumin), hemoglobin A(1c) (HbA(1c)), hemoglobin, subjective global nutritional assessment (SGA), and glomerular filtration rate (GFR) were analyzed. Kruskal-Wallis test was used to compare groups and Spearman's rank correlation test was used for continuous variables. HMGB-1, measured by Western blot, was significantly (P < 0.001) elevated in CKD 5 (146.7 +/- 58.6 ng/mL) and CKD 3-4 (85.6 +/- 31.8) compared with controls (10.9 +/- 10.5). HMGB-1 levels were correlated positively with TNF (Rho = 0.52; P < 0.001), hs-CRP (Rho = 0.38; P < 0.001), IL-6 (Rho = 0.30; P < 0.001), HbA(1c) (Rho = 0.14; P = 0.02) and SGA (Rho = 0.21; P = 0.002) and negatively correlated with GFR (Rho = -0.69; P = 0.0001), Hb (Rho = -0.60; P < 0.001), S-albumin (Rho = -0.31; P < 0.001). The current study has revealed that HMGB-1 is elevated significantly in CKD patients and correlates with GFR as well as markers of inflammation and malnutrition. Future studies may delineate whether HMGB-1 is also a marker of disease activity and severity as well as a predictor of outcome in CKD.

  6. High Ki-67 Immunohistochemical Reactivity Correlates With Poor Prognosis in Bladder Carcinoma

    Science.gov (United States)

    Luo, Yihuan; Zhang, Xin; Mo, Meile; Tan, Zhong; Huang, Lanshan; Zhou, Hong; Wang, Chunqin; Wei, Fanglin; Qiu, Xiaohui; He, Rongquan; Chen, Gang

    2016-01-01

    correlated with all 5 clinical outcome in Asian and European-American patients (P < 0.05). For multivariate analysis, however, the pooled results were only significant for DFS, OS, and RFS in Asian patients, for CSS, DFS, PFS, and RFS in European-American patients (P < 0.05). In the subgroup with low cut-off value (<20%), our meta-analysis indicated that high Ki-67 reactivity was significantly correlated with worsened CSS, DFS, OS, PFS, and RFS on univariate analysis (P < 0.05). For multivariate analysis, the meta-analysis of literature with low cut-off value (<20%) demonstrated that high Ki-67 reactivity predicted shorter DFS, PFS, and RFS in BC patients (P < 0.05). In the subgroup analysis of high cut-off value (≥20%), our meta-analysis indicated that high Ki-67 reactivity, in either univariate or multivariate analysis, significantly correlated with all five clinical outcomes in BC patients (P < 0.05). The meta-analysis indicates that high Ki-67 reactivity significantly correlates with deteriorated clinical outcomes in BC patients and that Ki-67 can be considered as an independent indicator for the prognosis by the meta-analyses of multivariate analysis. PMID:27082587

  7. Standardized precipitation index based on pearson type III distribution Índice padronizado de precipitação baseado na distribuição pearson tipo III

    Directory of Open Access Journals (Sweden)

    Gabriel Constantino Blain

    2011-06-01

    Full Text Available The initial step in calculating the Standardized Precipitation Index (SPI is to determine a probability density function (pdf that describes the precipitation series under analysis. Once this pdf is determined, the cumulative probability of an observed precipitation amount is computed. The inverse normal function is then applied to the cumulative probability. The result is the SPI. This article assessed the changes in SPI final values, when computed based on Gamma 2-parameters (Gam and Pearson Type III (PE3 distributions (SPIGam and SPIPE3, respectively. Monthly rainfall series, available from five weather stations of the State of São Paulo, were chosen for this study. Considering quantitative and qualitative assessments of goodness-of-fit (evaluated at 1-, 3-, and 6-months precipitation totals, the PE3 distribution seems to be a better choice than the Gam distribution, in describing the long-term rainfall series of the State of São Paulo. In addition, it was observed that the number of SPI time series that could be seen as normally distributed was higher when this drought index was computed from the PE3 distribution. Thus, the use of the Pearson type III distribution within the calculation algorithm of the SPI is recommended in the State of São Paulo.O cálculo do Índice Padronizado de Precipitação (IPP inicia-se com a adoção de uma distribuição paramétrica (dp utilizada para a estimativa das probabilidades de ocorrência associadas a uma série de precipitação pluvial. Após essa escolha, a probabilidade acumulada de ocorrência de um determinado valor de precipitação é calculada. O IPP é obtido após a aplicação da função normal inversa a essa probabilidade acumulada. O artigo avaliou as alterações nos valores finais do IPP, quando calculado com base nas distribuições Gama com dois parâmetros (Gam e Pearson tipo III (PE3; IPPGam e IPPPE3, respectivamente. Utilizaram-se dados de precipitação pluvial de cinco

  8. A high performance cost-effective digital complex correlator for an X-band polarimetry survey.

    Science.gov (United States)

    Bergano, Miguel; Rocha, Armando; Cupido, Luís; Barbosa, Domingos; Villela, Thyrso; Boas, José Vilas; Rocha, Graça; Smoot, George F

    2016-01-01

    The detailed knowledge of the Milky Way radio emission is important to characterize galactic foregrounds masking extragalactic and cosmological signals. The update of the global sky models describing radio emissions over a very large spectral band requires high sensitivity experiments capable of observing large sky areas with long integration times. Here, we present the design of a new 10 GHz (X-band) polarimeter digital back-end to map the polarization components of the galactic synchrotron radiation field of the Northern Hemisphere sky. The design follows the digital processing trends in radio astronomy and implements a large bandwidth (1 GHz) digital complex cross-correlator to extract the Stokes parameters of the incoming synchrotron radiation field. The hardware constraints cover the implemented VLSI hardware description language code and the preliminary results. The implementation is based on the simultaneous digitized acquisition of the Cartesian components of the two linear receiver polarization channels. The design strategy involves a double data rate acquisition of the ADC interleaved parallel bus, and field programmable gate array device programming at the register transfer mode. The digital core of the back-end is capable of processing 32 Gbps and is built around an Altera field programmable gate array clocked at 250 MHz, 1 GSps analog to digital converters and a clock generator. The control of the field programmable gate array internal signal delays and a convenient use of its phase locked loops provide the timing requirements to achieve the target bandwidths and sensitivity. This solution is convenient for radio astronomy experiments requiring large bandwidth, high functionality, high volume availability and low cost. Of particular interest, this correlator was developed for the Galactic Emission Mapping project and is suitable for large sky area polarization continuum surveys. The solutions may also be adapted to be used at signal processing

  9. High frequency magnetic fluctuations correlated with the inter-ELM pedestal evolution in ASDEX Upgrade

    Science.gov (United States)

    Laggner, F. M.; Wolfrum, E.; Cavedon, M.; Mink, F.; Viezzer, E.; Dunne, M. G.; Manz, P.; Doerk, H.; Birkenmeier, G.; Fischer, R.; Fietz, S.; Maraschek, M.; Willensdorfer, M.; Aumayr, F.; the EUROfusion MST1 Team; the ASDEX Upgrade Team

    2016-06-01

    In order to understand the mechanisms that determine the structure of the high confinement mode (H-mode) pedestal, the evolution of the plasma edge electron density and temperature profiles between edge localised modes (ELMs) is investigated. The onset of radial magnetic fluctuations with frequencies above 200 kHz is found to correlate with the stagnation of the electron temperature pedestal gradient. During the presence of these magnetic fluctuations the gradients of the edge electron density and temperature are clamped and stable against the ELM onset. The detected magnetic fluctuation frequency is analysed for a variety of plasma discharges with different electron pressure pedestals. It is shown that the magnetic fluctuation frequency scales with the neoclassically estimated \\text{E} × \\text{B} velocity at the plasma edge. This points to a location of the underlying instability in the gradient region. Furthermore, the magnetic signature of these fluctuations indicates a global mode structure with toroidal mode numbers of approximately 10. The fluctuations are also observed on the high field side with significant amplitude, indicating a mode structure that is symmetric on the low field side and high field side. The associated fluctuations in the current on the high field side might be attributed to either a strong peeling part or the presence of non-adiabatic electron response.

  10. Towards high velocity deformation characterisation of metals and composites using Digital Image Correlation

    Directory of Open Access Journals (Sweden)

    Dulieu-Barton J.M.

    2010-06-01

    Full Text Available Characterisation of materials subject to high velocity deformation is necessary as many materials behave differently under such conditions. It is particularly important for accurate numerical simulation of high strain rate events. High velocity servo-hydraulic test machines have enabled material testing in the strain rate regime from 1 – 500 ε/s. The range is much lower than that experienced under ballistic, shock or impact loads, nevertheless it is a useful starting point for the application of optical techniques. The present study examines the possibility of using high speed cameras to capture images and then extracting deformation data using Digital Image Correlation (DIC from tensile testing in the intermediate strain rate regime available with the test machines. Three different materials, aluminium alloy 1050, S235 steel and glass fibre reinforced plastic (GFRP were tested at different nominal strain rates ranging from quasi static to 200 ε/s. In all cases DIC was able to analyse data collected up to fracture and in some cases post fracture. The use of highspeed DIC made it possible to capture phenomena such as multiple necking in the aluminium specimens and post compression failure in GFRP specimens.

  11. Doping dependence of spin excitations and its correlations with high-temperature superconductivity in iron pnictides.

    Science.gov (United States)

    Wang, Meng; Zhang, Chenglin; Lu, Xingye; Tan, Guotai; Luo, Huiqian; Song, Yu; Wang, Miaoyin; Zhang, Xiaotian; Goremychkin, E A; Perring, T G; Maier, T A; Yin, Zhiping; Haule, Kristjan; Kotliar, Gabriel; Dai, Pengcheng

    2013-01-01

    High-temperature superconductivity in iron pnictides occurs when electrons and holes are doped into their antiferromagnetic parent compounds. Since spin excitations may be responsible for electron pairing and superconductivity, it is important to determine their electron/hole-doping evolution and connection with superconductivity. Here we use inelastic neutron scattering to show that while electron doping to the antiferromagnetic BaFe₂As₂ parent compound modifies the low-energy spin excitations and their correlation with superconductivity (100 meV), hole-doping suppresses the high-energy spin excitations and shifts the magnetic spectral weight to low-energies. In addition, our absolute spin susceptibility measurements for the optimally hole-doped iron pnictide reveal that the change in magnetic exchange energy below and above T(c) can account for the superconducting condensation energy. These results suggest that high-T(c) superconductivity in iron pnictides is associated with both the presence of high-energy spin excitations and a coupling between low-energy spin excitations and itinerant electrons.

  12. Correlation of microstructure, tensile properties and hole expansion ratio in cold rolled advanced high strength steels

    Science.gov (United States)

    Terrazas, Oscar R.

    The demand for advanced high strength steels (AHSS) with higher strengths is increasing in the automotive industry. While there have been major improvements recently in the trade-off between ductility and strength, sheared-edge formability of AHSS remains a critical issue. AHSS sheets exhibit cracking during stamping and forming operations below the predictions of forming limits. It has become important to understand the correlation between microstructure and sheared edge formability. The present work investigates the effects of shearing conditions, microstructure, and tensile properties on sheared edge formability. Seven commercially produced steels with tensile strengths of 1000 +/- 100 MPa were evaluated: five dual-phase (DP) steels with different compositions and varying microstructural features, one trip aided bainitic ferrite (TBF) steel, and one press-hardened steel tempered to a tensile strength within the desired range. It was found that sheared edge formability is influenced by the martensite in DP steels. Quantitative stereology measurements provided results that showed martensite size and distribution affect hole expansion ratio (HER). The overall trend is that HER increases with more evenly dispersed martensite throughout the microstructure. This microstructure involves a combination of martensite size, contiguity, mean free distance, and number of colonies per unit area. Additionally, shear face characterization showed that the fracture and burr region affect HER. The HER decreases with increasing size of fracture and burr region. With a larger fracture and burr region more defects and/or micro-cracks will be present on the shear surface. This larger fracture region on the shear face facilitates cracking in sheared edge formability. Finally, the sheared edge formability is directly correlated to true fracture strain (TFS). The true fracture strain from tensile samples correlates to the HER values. HER increases with increasing true fracture strain.

  13. HIGH RESOLUTION SONOGRAPHIC EVALUATION OF PALPABLE THYROID LESIONS WITH HISTOPATHOLOGICAL CORRELATION- A PROSP ECTIVE STUDY

    Directory of Open Access Journals (Sweden)

    Malik

    2013-05-01

    Full Text Available ABSTRACT: Thyroid lesions are found in 3-7% of population wor ldwide. The overwhelming majority of thyroid nodules are benign in nature. Thyroid ca ncers are rare; however thyroid carcinoma is the most common malignancy involving the endocrine glan ds and is responsible for approximately 1.5% of new cancer cases annually. The clinical challeng e is to distinguish the few clinically significant malignant nodules from the many benign nodules beca use malignant thyroid lesions shows good long term prognosis after surgical excision. Aims : To Assess the sensitivity and specificity of sonographic findings in differentiation of benign a nd malignant thyroid lesion. Method: A hospital based prospective study was done on 100 patients wi th palpable thyroid nodules using high resolution ultrasonography and findings correlated with fine needle aspiration cytology. Result: Sensitivity and Specificity of sonography to differ entiate benign and malignant thyroid lesions (FNAC correlation was 70.59 % & 96.39 % respectively. Pr esence of non shadowing echogenic cholesterol crystals showed high sensitivity of 58.70 % and spe cificity of 83.33 % for benign thyroid nodules. Sensitivity and Specificity of absence of thin peri pheral halo around malignant lesions were 70.4 % & 65.8% respectively. Sensitivity and Specificity of hypoechogenicity for malignant lesions were 64.71 % and 98.80 %.Presence of fine calcification was sh owing high Sensitivity & Specificity of 64.71 % and 93.98 % respectively in malignant lesions. Pred ominant intra-nodular colour flow pattern in solid nodules was predictive of malignancy with Sensitivi ty 82.35 and Specificity 84.34 %. Higher RI value (greater than 0.77 were significantly found in mal ignant lesions with sensitivity of 78.57 % and specificity of 92.31%. Solid and predominantly soli d lesions show high Sensitivity, Specificity for being a malignant lesion 70.59 % & 55.42 respective ly but less Positive Predictive Value of24

  14. A new procedure of modal parameter estimation for high-speed digital image correlation

    Science.gov (United States)

    Huňady, Róbert; Hagara, Martin

    2017-09-01

    The paper deals with the use of 3D digital image correlation in determining modal parameters of mechanical systems. It is a non-contact optical method, which for the measurement of full-field spatial displacements and strains of bodies uses precise digital cameras with high image resolution. Most often this method is utilized for testing of components or determination of material properties of various specimens. In the case of using high-speed cameras for measurement, the correlation system is capable of capturing various dynamic behaviors, including vibration. This enables the potential use of the mentioned method in experimental modal analysis. For that purpose, the authors proposed a measuring chain for the correlation system Q-450 and developed a software application called DICMAN 3D, which allows the direct use of this system in the area of modal testing. The created application provides the post-processing of measured data and the estimation of modal parameters. It has its own graphical user interface, in which several algorithms for the determination of natural frequencies, mode shapes and damping of particular modes of vibration are implemented. The paper describes the basic principle of the new estimation procedure which is crucial in the light of post-processing. Since the FRF matrix resulting from the measurement is usually relatively large, the estimation of modal parameters directly from the FRF matrix may be time-consuming and may occupy a large part of computer memory. The procedure implemented in DICMAN 3D provides a significant reduction in memory requirements and computational time while achieving a high accuracy of modal parameters. Its computational efficiency is particularly evident when the FRF matrix consists of thousands of measurement DOFs. The functionality of the created software application is presented on a practical example in which the modal parameters of a composite plate excited by an impact hammer were determined. For the

  15. Thalamo-Sensorimotor Functional Connectivity Correlates with World Ranking of Olympic, Elite, and High Performance Athletes

    Directory of Open Access Journals (Sweden)

    Zirui Huang

    2017-01-01

    Full Text Available Brain plasticity studies have shown functional reorganization in participants with outstanding motor expertise. Little is known about neural plasticity associated with exceptionally long motor training or of its predictive value for motor performance excellence. The present study utilised resting-state functional magnetic resonance imaging (rs-fMRI in a unique sample of world-class athletes: Olympic, elite, and internationally ranked swimmers (n=30. Their world ranking ranged from 1st to 250th: each had prepared for participation in the Olympic Games. Combining rs-fMRI graph-theoretical and seed-based functional connectivity analyses, it was discovered that the thalamus has its strongest connections with the sensorimotor network in elite swimmers with the highest world rankings (career best rank: 1–35. Strikingly, thalamo-sensorimotor functional connections were highly correlated with the swimmers’ motor performance excellence, that is, accounting for 41% of the individual variance in best world ranking. Our findings shed light on neural correlates of long-term athletic performance involving thalamo-sensorimotor functional circuits.

  16. Electrophysiological Changes Correlated with Temperature Increases Induced by High-Intensity Focused Ultrasound Ablation

    Science.gov (United States)

    Wu, Z.; Kumon, R. E.; Laughner, J. I.; Efimov, I. R.; Deng, C. X.

    2014-01-01

    To gain better understanding of the detailed mechanisms of high-intensity focused ultrasound (HIFU) ablation for cardiac arrhythmias, we investigated how the cellular electrophysiological (EP) changes were correlated with temperature increases and thermal dose (cumulative equivalent minutes [CEM43]) during HIFU application using Langendorff-perfused rabbit hearts. Employing voltage-sensitive dye di-4-ANEPPS, we measured the EP and temperature during HIFU using simultaneous optical mapping and infrared imaging. Both action potential amplitude (APA) and AP duration at 50% repolarization (APD50) decreased with temperature increases, and APD50 was more thermally sensitive than APA. EP and tissue changes were irreversible when HIFU-induced temperature increased above 52.3 ± 1.4 °C and log10(CEM43) above 2.16 ± 0.51 (n = 5), but were reversible when temperature was below 50.1 ± 0.8 °C and log10(CEM43) below −0.9 ± 0.3 (n = 9). EP and temperature/thermal dose changes were spatially correlated with HIFU induced tissue necrosis surrounded by a transition zone. PMID:25516446

  17. Correlation of Thermally Induced Pores with Microstructural Features Using High Energy X-rays

    Science.gov (United States)

    Menasche, David B.; Shade, Paul A.; Lind, Jonathan; Li, Shiu Fai; Bernier, Joel V.; Kenesei, Peter; Schuren, Jay C.; Suter, Robert M.

    2016-11-01

    Combined application of a near-field High Energy Diffraction Microscopy measurement of crystal lattice orientation fields and a tomographic measurement of pore distributions in a sintered nickel-based superalloy sample allows pore locations to be correlated with microstructural features. Measurements were carried out at the Advanced Photon Source beamline 1-ID using an X-ray energy of 65 keV for each of the measurement modes. The nickel superalloy sample was prepared in such a way as to generate significant thermally induced porosity. A three-dimensionally resolved orientation map is directly overlaid with the tomographically determined pore map through a careful registration procedure. The data are shown to reliably reproduce the expected correlations between specific microstructural features (triple lines and quadruple nodes) and pore positions. With the statistics afforded by the 3D data set, we conclude that within statistical limits, pore formation does not depend on the relative orientations of the grains. The experimental procedures and analysis tools illustrated are being applied to a variety of materials problems in which local heterogeneities can affect materials properties.

  18. Correlation of understanding of physics and psychological symptoms among high-school students in Greece

    Science.gov (United States)

    Aggeliki, Anagnostopoulou; Miltiades, Kyprianou; Antigoni-Elisavet, Rota; Evangelia, Pavlatou; Loizos, Zaphiris

    2017-09-01

    Depression may essentially influence cognitive function contributing to poor school performance. The present study undertakes to determine the existence and strength of correlation between depressive symptomatology and other mental conditions with the acquired level of understanding of Newtonian physics taught in schools. The current study recruited 490 students (262 girls, 228 boys) attending the first semester of the Greek Second Grade of General Lyceum School. Force Concept Inventory (FCI) tested the depth of the students’ understanding of Newtonian Physics. Symptom Checklist-90-R assessed general mental status. The tests took place in the classroom during a 1 h session. Low FCI scores significantly correlated with mental conditions, with depression ranking first. Girls had higher scores in all nine symptoms scales of SCL-90 and lower FCI scores. Stepwise regression models proved that the gender effect on FCI could be effectively explained through the significant effect of depression. An understanding of Newtonian physics among high school students may be restricted by common problematic mental conditions, with depression being the greatest among all. Further research, using a more systematic approach to measure depression among adolescents with poor understanding of physics, would help to elucidate the nature of the effect.

  19. High resolution CT in children with cystic fibrosis: correlation with pulmonary functions and radiographic scores

    Energy Technology Data Exchange (ETDEWEB)

    Demirkazik, Figen Basaran E-mail: demirkaz@dialup.ankara.edu.tr; Ariyuerek, O. Macit; Oezcelik, Ugur; Goecmen, Ayhan; Hassanabad, Hossein K.; Kiper, Nural

    2001-01-01

    Objective: To compare the high resolution CT (HRCT) scores of the Bhalla system with pulmonary function tests and radiographic and clinical points of the Shwachman-Kulczycki clinical scoring system. Methods: HRCT of the chest was obtained in 40 children to assess the role of HRCT in evaluating bronchopulmonary pathology in children with cystic fibrosis (CF). The HRCT severity scores of the Bhalla system were compared with chest radiographic and clinical points of the Shwachman-Kulczycki scoring system and pulmonary function tests. Only 14 of the patients older than 6 years cooperated with spirometry. Results: HRCT scores correlated well with radiographic points (r=0.80, P<0.0001) and clinical points (r=0.67, P<0.0001) of the Shwachman-Kulczycki system, FVC (r=0.71 P=0.004) and FEV{sub 1} (r=0.66, P=0.01). Although radiographic points correlated significantly with FVC (r=0.61, P=0.02) and FEV{sub 1} (r=0.56, P=0.04), HRCT provides a more precise scoring than the chest X-ray. Conclusion: The HRCT scoring system may provide a sensitive method of monitoring pulmonary disease status and may replace the radiographic scoring in the Shwachman-Kulczycki system. It may be helpful especially in follow-up of small children too young to cooperate with spirometry.

  20. Correlates of high perceived stress among pregnant Hispanic women in Western Massachusetts.

    Science.gov (United States)

    Silveira, Marushka Leanne; Pekow, Penelope S; Dole, Nancy; Markenson, Glenn; Chasan-Taber, Lisa

    2013-08-01

    Prenatal psychosocial stress has been associated with adverse pregnancy outcomes, even after controlling for known risk factors. This paper aims to evaluate correlates of high perceived stress among Hispanic women, a group with elevated rates of stress during pregnancy. We conducted this analysis among 1,426 pregnant Hispanic women using data from Proyecto Buena Salud, a prospective cohort study conducted in Western Massachusetts. Cohen's Perceived Stress Scale (PSS-14) validated in English and Spanish was administered in early (mean = 12.4 weeks gestation), mid (mean = 21.3 weeks gestation) and late (mean = 30.8 weeks gestation) pregnancy at which time bilingual interviewers collected data on socio-demographic, acculturation, behavioral, and psychosocial factors. High perceived stress was defined as a PSS score >30. Young maternal age (odds ratio (OR) = 0.6; 95 % confidence interval (CI) 0.4-0.9 for 12 drinks/month vs. none) and smoking (OR = 2.2; 95 % CI 1.3-3.7 for >10 cigarettes/day vs. none) were associated with high perceived stress during early pregnancy. Furthermore, higher annual household income (OR = 0.4; 95 % CI 0.1-0.9 for >$30,000 vs. <$15,000), greater number of adults in the household (OR = 1.8; 95 % CI 1.1-3.0 for ≥3 vs. 1) and language preference (OR = 0.6; 95 % CI 0.4-0.9 for Spanish vs. English) were associated with high stress during mid-pregnancy. Likewise, annual household income was inversely associated with high stress during late pregnancy. Our results have important implications for incorporation of routine screening for psychosocial stress during prenatal visits and implementation of psychosocial counseling services for women at high risk.

  1. Expression of the Arabidopsis high-affinity hexose transporter STP13 correlates with programmed cell death.

    Science.gov (United States)

    Norholm, Morten H H; Nour-Eldin, Hussam H; Brodersen, Peter; Mundy, John; Halkier, Barbara A

    2006-04-17

    We report the biochemical characterization in Xenopus oocytes of the Arabidopsis thaliana membrane protein, STP13, as a high affinity, hexose-specific H(+)-symporter. Studies with kinase activators suggest that it is negatively regulated by phosphorylation. STP13 promoter GFP reporter lines show GFP expression only in the vascular tissue in emerging petals under non-stressed conditions. Quantitative PCR and the pSTP13-GFP plants show induction of STP13 in programmed cell death (PCD) obtained by treatments with the fungal toxin fumonisin B1 and the pathogen Pseudomonas syringae. A role for STP13 in PCD is supported by microarray data from e.g. plants undergoing senescence and a strong correlation between STP13 transcripts and the PCD phenotype in different accelerated cell death (acd11) mutants.

  2. High-Resolution Correlated Fission Product Measurements of 235U (nth , f) with SPIDER

    Science.gov (United States)

    Shields, Dan; Spider Team

    2015-10-01

    The SPIDER detector (SPectrometer for Ion DEtermination in fission Research) has obtained high-resolution, moderate-efficiency, correlated fission product data needed for many applications including the modeling of next generation nuclear reactors, stockpile stewardship, and the fundamental understanding of the fission process. SPIDER simultaneously measures velocity and energy of both fission products to calculate fission product yields (FPYs), neutron multiplicity (ν), and total kinetic energy (TKE). These data will be some of the first of their kind available to nuclear data evaluations. An overview of the SPIDER detector, analytical method, and preliminary results for 235U (nth , f) will be presented. LA-UR-15-20130 This work benefited from the use of the LANSCE accelerator facility and was performed under the auspices of the US Department of Energy by Los Alamos Security, LLC under Contract DE-AC52-06NA25396.

  3. Anisotropic particle production and azimuthal correlations in high-energy pA collisions

    CERN Document Server

    Dumitru, Adrian; Skokov, Vladimir

    2015-01-01

    We summarize some recent ideas relating to anisotropic particle production in high-energy collisions. Anisotropic gluon distributions lead to anisotropies of the single-particle azimuthal distribution and hence to disconnected contributions to multi-particle cumulants. When these dominate, the four-particle elliptic anisotropy $c_2\\{4\\}$ changes sign. On the other hand, connected diagrams for $m$-particle cumulants are found to quickly saturate with increasing $m$, a ``coherence'' quite unlike conventional ``non-flow'' contributions such as decays. Finally, we perform a first exploratory phenomenological analysis in order to estimate the amplitude ${\\cal A}$ of the $\\cos(2\\varphi)$ anisotropy of the gluon distribution at small $x$, and we provide a qualitative prediction for the elliptic asymmetry from three-particle correlations, $c_2\\{3\\}$.

  4. Correlates of violent and nonviolent victimization in a sample of public high school students.

    Science.gov (United States)

    Van Dorn, Richard A

    2004-06-01

    This study investigates the extent to which student reports of violent and nonviolent victimization in public high schools is associated the presence of hate-related words or symbols, the availability of hard and soft drugs, and the presence of gangs. Data from the 1999 School Crime Supplement of the National Crime Victimization Survey were used for this analysis. In the final multinomial logistic regression model, the presence of hate-related words, the availability of hard drugs, and a gang presence were significantly associated with reports of violent victimization. The availability of soft drugs was significantly associated with nonviolent victimization. Findings held across gender, race/ethnicity, and urbanicity of the school's location with younger students more likely to be both violently and nonviolently victimized than older students. Implications for primary and secondary interventions aimed at school climate and the reduction of correlates of victimization are discussed.

  5. Galactic synchrotron emission and the FIR-radio correlation at high redshift

    CERN Document Server

    Schober, Jennifer; Klessen, Ralf S

    2016-01-01

    Galactic magnetic fields in the local Universe are strong and omnipresent. Now evidence accumulates that galaxies were magnetized already in the early Universe. Theoretical scenarios including the turbulent small-scale dynamo predict magnetic energy densities comparable to the one of turbulence. Based on the assumption of this energy equipartition, we determine the galactic synchrotron flux as a function of redshift. The conditions in the early Universe are different from the present day, in particular the galaxies have more intense star formation. To cover a large range of conditions we consider models based on two different types of galaxies: one model galaxy comparable to the Milky Way and one typical high-z starburst galaxy. We include a model of the steady state cosmic ray spectrum and find that synchrotron emission can be detected up to cosmological redshifts with current and future radio telescopes. Turbulent dynamo theory is in agreement with the origin of the observed correlation between the far-infr...

  6. Multiple Correlations and High Tranverse Momentum Jets in 147-GeV/c pi- p Interactions

    Energy Technology Data Exchange (ETDEWEB)

    Brick, D.; Shapiro, A.M.; Widgoff, M.; /Brown U.; Alyea, E.D., Jr.; /Indiana U.; Hafen, Elizabeth S.; Hulsizer, R.I.; Kistiakowsky, V.; Levy, A.; Lutz, P.; Oh, S.H.; Pless, I.A.; /MIT, LNS /Oak Ridge /Rutgers U., Piscataway /Stevens Tech. /Tennessee U. /Yale U.

    1981-03-01

    We examine multiparticle correlations in a {pi}{sup -}p experiment at 147 GeV/c performed by the Proportional Hybrid System Consortium. The major aim of this paper is to demonstrate the existence of clusters in our data. We use different statistical algorithms to assemble into clusters the particles in each event which are associated by virtue of small relative angles. We find that these clusters are stable against different choices of metric and/or algorithm, and reproduce the effects previously observed in the data corresponding to clusters. Some of these clusters have properties similar to high p{sub T} jets. A detailed study of these jet-like clusters is described, and comparisons with some counter experiments are discussed.

  7. Correlating GRACE with Standardized Precipitation Indices and Precipitation Gauges for the High Plains Aquifer

    Science.gov (United States)

    Miller, K. A.; Clancy, K.

    2016-12-01

    The NASA and German Aerospace Center Gravity Recovery and Climate Experiment (GRACE) detects monthly changes in the gravity of the earth assumed to be water storage using the distance between two satellites, GRACE A and GRACE B, as a phase change. We will use level 3 GRACE Tellus data from the NASA Jet Propulsion Laboratory Physical Oceanography Distributed Active Archive Center (PO.DAAC). The data have a resolution of 9 km2 and are available for 2002 to 2015. We examine GRACE data for the High Plains aquifer (Texas, Oklahoma, Wyoming, Nebraska, Kansas, New Mexico, Colorado and South Dakota) and compare changes to monthly averaged precipitation gauges, standardized precipitation indices for one, three, six, and twelve-months. We hypothesize that GRACE data will correlate best with 1) three-month standardized precipitation indices; 2) regions with natural land cover; 3) and in years where precipitation is at or above average.

  8. Nuclear quantum and electronic exchange-correlation effects on the high pressure phase diagram of lithium

    Science.gov (United States)

    Clay, Raymond; Morales, Miguel; Bonev, Stanimir

    Lithium at ambient conditions is the simplest alkali metal and exhibits textbook nearly-free electron character. However, increased core/valence electron overlap under compression leads to surprisingly complex behavior. Dense lithium is known to posses a maximum in the melting line, a metal to semiconductor phase transition around 80GPa, reemergent metallicity around 120GPa, and low coordination solid and liquid phases. In addition to its complex electronic structure at high pressure, the atomic mass of lithium is low enough that nuclear quantum effects could have a nontrivial impact on its phase diagram. Through a combination of density functional theory based path-integral and classical molecular dynamics simulations, we have investigated the impact of both nuclear quantum effects and anharmonicity on the melting line and solid phase boundaries. Additionally, we have determined the robustness of previously predicted tetrahedral clustering in the dense liquid to the inclusion of nuclear quantum effects and approximate treatment of electronic exchange-correlation effects.

  9. The impact of highly correlated potential energy surfaces on the anharmonically corrected IR spectrum of acetonitrile

    Science.gov (United States)

    Lutz, Oliver M. D.; Rode, Bernd M.; Bonn, Günther K.; Huck, Christian W.

    2014-10-01

    This paper discusses the quality and feasibility of highly correlated ab initio techniques in a vibrational self-consistent field (VSCF) approach using acetonitrile as a model system. The topical renormalized coupled-cluster technique exploiting the similarity-transformed Hamiltonian's left eigenstates (i.e. CR-CC(2,3)) is investigated alongside the well-known Hartree-Fock (HF), Møller-Plesset second-order perturbation theory (MP2) and coupled cluster (CCSD(T)) methods. The inclusion of mode triple interactions is discussed and it is found that the use of an effective core potential (ECP) serves as a viable compromise during the highly demanding task of computing such contributions, thus enabling a grid-based evaluation of three mode interaction terms with coupled cluster techniques also for larger molecules. In this context, a previously proposed reduced coupling scheme [1] is investigated, confirming the applicability of this technique to a system exhibiting a rather complex electronic structure. A combination of Ahlrichs' triple-ζ valence polarized (TZVP) basis set with Dunning's set of core-valence correlation functions is found to deliver results in good agreement with experiment while being computationally very feasible. Since CH3CN exhibits four degenerate vibrational degrees of freedom, it serves as an ideal model system for critically assessing the qualities of the degenerate second-order perturbation theory corrected (DPT2) VSCF technique. Besides fundamental vibrations, a thorough investigation of overtone transitions and combination bands is conducted by means of comparing the results to both available and newly recorded experimental data.

  10. Reduced Popdc3 expression correlates with high risk and poor survival in patients with gastric cancer

    Institute of Scientific and Technical Information of China (English)

    Deng Luo; Ming-Liang Lu; Gong-Fang Zhao; Hua Huang; Meng-Yao Zheng; Jiang Chang; Lin Lv

    2012-01-01

    AIM:To investigate the expression of Popeye domain containing 3 (Popdc3) and its correlation with clinicopathological features and prognosis of gastric cancer.METHODS:The method of immunohistochemistry was used to investigate the expression of Popdc3 in 306 cases of human gastric cancer and 84 noncancerous gastric tissues.Simultaneously,the relationship between Popdc3 expression and the survival of the patients was retrospectively analyzed.RESULTS:Popdc3 was detected in 72 (85.71%) of 84 human nontumor mucosa.High expression of Popdc3 protein was detected in 78 (25.49%) of 306 human gastric cancer cases,and low expression was detected in 228 (74.51%).Low expression of Popdc3 correlated with depth of invasion (P < 0.0001),regional lymph nodes (P < 0.0001) and distant metastasis (P =0.02),and tumor,nodes,metastasis (TNM) stages (P< 0.0001).On multivariate analysis,only the patient's gender,regional lymph node metastasis,distant metastasis,TNM stages,and the expression of Popdc3 were independent prognostic factors in patients with gastric cancer.The Kaplan-Meier plot showed that low Popdc3 expression had a much more significant effect on the survival of those patients with early-stage tumors (x2 =104.741,P < 0.0001),with a > 51.9% reduction in the three-year survival compared with high Popdc3 expression.In late stages,the difference was also significant (x2 =5.930,P =0.015),with a 32.6% reduction in the three-year survival.CONCLUSION:Reduced expression of Popdc3 may play a significant role in the carcinogenesis and progression of gastric cancer.Popdc3 may be an independent prognostic factor.

  11. Patterns and correlates of new psychoactive substance use in a sample of Australian high school students.

    Science.gov (United States)

    Champion, Katrina E; Teesson, Maree; Newton, Nicola C

    2016-05-01

    In recent years there has been growing concern about new psychoactive substances (NPS) designed to mimic the effects of established illicit drugs. This paper explores the patterns and correlates of NPS use in a sample of Australian students. A cross-sectional survey was conducted in Australia in 2014. Data were collected from 1126 students (mean age: 14.9 years) from 11 secondary schools. Students completed a self-report questionnaire assessing NPS use and knowledge, beliefs and intentions to use these substances. NPS users were compared with non-users and illicit drug users, who had not used NPS, in terms of gender, binge drinking, tobacco use, psychological distress and self-efficacy to resist peer pressure. Of the 1126 students, 3% reported having ever tried NPS, 2.4% had used synthetic cannabis and 0.4% had used a synthetic stimulant. Analyses revealed that NPS users were more likely to have had an episode of binge drinking in the past 6 months, tried tobacco and had higher levels of psychological distress and lower perceived self-efficacy to resist peer pressure than non-users, but did not significantly differ from users of other illicit drugs. NPS use appears to be uncommon among Australian school students. Although adolescents that do use these substances did not differ from students that had used traditional illicit drugs, both appear to be higher-risk groups of students than non-users. Our findings suggest that universal education about NPS be incorporated into existing drug prevention programmes, and that targeted NPS prevention may also be warranted among high-risk adolescents. [Champion KE, Teesson M, Newton NC. Patterns and correlates of new psychoactive substance use in a sample of Australian high school students. Drug Alcohol Rev 2016;35:338-344]. © 2015 Australasian Professional Society on Alcohol and other Drugs.

  12. Predicting protein-protein interactions from sequence using correlation coefficient and high-quality interaction dataset.

    Science.gov (United States)

    Shi, Ming-Guang; Xia, Jun-Feng; Li, Xue-Ling; Huang, De-Shuang

    2010-03-01

    Identifying protein-protein interactions (PPIs) is critical for understanding the cellular function of the proteins and the machinery of a proteome. Data of PPIs derived from high-throughput technologies are often incomplete and noisy. Therefore, it is important to develop computational methods and high-quality interaction dataset for predicting PPIs. A sequence-based method is proposed by combining correlation coefficient (CC) transformation and support vector machine (SVM). CC transformation not only adequately considers the neighboring effect of protein sequence but describes the level of CC between two protein sequences. A gold standard positives (interacting) dataset MIPS Core and a gold standard negatives (non-interacting) dataset GO-NEG of yeast Saccharomyces cerevisiae were mined to objectively evaluate the above method and attenuate the bias. The SVM model combined with CC transformation yielded the best performance with a high accuracy of 87.94% using gold standard positives and gold standard negatives datasets. The source code of MATLAB and the datasets are available on request under smgsmg@mail.ustc.edu.cn.

  13. Development of a high-performance multichannel system for time-correlated single photon counting

    Science.gov (United States)

    Peronio, P.; Cominelli, A.; Acconcia, G.; Rech, I.; Ghioni, M.

    2017-05-01

    Time-Correlated Single Photon Counting (TCSPC) is one of the most effective techniques for measuring weak and fast optical signals. It outperforms traditional "analog" techniques due to its high sensitivity along with high temporal resolution. Despite those significant advantages, a main drawback still exists, which is related to the long acquisition time needed to perform a measurement. In past years many TCSPC systems have been developed with higher and higher number of channels, aimed to dealing with that limitation. Nevertheless, modern systems suffer from a strong trade-off between parallelism level and performance: the higher the number of channels the poorer the performance. In this work we present the design of a 32x32 TCSPC system meant for overtaking the existing trade-off. To this aim different technologies has been employed, to get the best performance both from detectors and sensing circuits. The exploitation of different technologies will be enabled by Through Silicon Vias (TSVs) which will be investigated as a possible solution for connecting the detectors to the sensing circuits. When dealing with a high number of channels, the count rate is inevitably set by the affordable throughput to the external PC. We targeted a throughput of 10Gb/s, which is beyond the state of the art, and designed the number of TCSPC channels accordingly. A dynamic-routing logic will connect the detectors to the lower number of acquisition chains.

  14. Psychosocial Correlates of the Need for Physical Education and Sports in High School

    Directory of Open Access Journals (Sweden)

    Mihai Curelaru

    2011-01-01

    Full Text Available Problem statement: Sports and movement activities play an important role in the harmonious development of children; Special attention should be paid to the factors influencing their involvement in sportive activities. The aim of this study was related to identifying possible psychosocial correlates of the need for physical education and sports in Romanian society and increasing awareness on the importance of sports in everyday life. Approach: 1100 high school students from the North-Eastern part of Romania answered a series of questionnaires that measured level of sports and movement appreciation, passion for sport, leisure and systematic sport practices, attitude towards bullying, instrumental and final values and, several socio-demographic variables: gender, parents’ level of education, type of high school attended and bullying. Results: The data showed that sport is more associated to boys, to students with low socioeconomic status and, to students attending centrally-located high schools; students who are passionate about sports manifest a negative attitude towards bullying. Conclusion: The results emphasized the need to reconsider Romanian academic curricula in order to stimulate competition activities in schools and to increase the number of sportive clubs and associations.

  15. Representações da Guerra Fria no discurso jornalístico norte-americano de Drew Pearson (1950-1960 =Representations of the Cold War in the north american journalistic discourse of Drew Pearson (1950-1960

    Directory of Open Access Journals (Sweden)

    Portela, Leonice

    2014-01-01

    Full Text Available O presente artigo pretende realizar uma análise nas páginas da revista O Cruzeiro no período de 1950 a 1960, na coluna Carrossel do Mundo escrita pelo jornalista norte-americano Drew Person. Nesta pesquisa evidenciaremos o cruzamento da história com a imprensa e as representações que esta fazia do contexto dos anos de 1950 a 1960. Além de utilizarmos a revistas O Cruzeiro como fonte de pesquisa, está também será nosso objeto de estudo na medida em que se pretende analisar a revista nos seus intrincados bastidores e relações com o poder. A revista é fonte de sua própria história e das mais diversas situações, encontramos dados sobre a sociedade, costumes, informando sobre questões políticas e econômicas inseridas em suas representações através de suas palavras e imagens. Realizaremos um panorama dos artigos de Drew Pearson no período de 1950 a 1960, sendo classificadas em três Eixos Temáticos que se destacam como: a Articulações Políticas dos Estados Unidos nas relações internas e externas; b As ameaças do Comunismo; c Guerra Fria na sua perspectiva de “guerra de nervos”.

  16. Canine classical seminoma: a specific malignant type with human classifications is highly correlated with tumor angiogenesis

    Directory of Open Access Journals (Sweden)

    Kim Jong-Hyuk

    2010-05-01

    Full Text Available Abstract Background Human seminoma is classified as classical seminoma (SE and spermatocytic seminoma (SS. Human SE is known to be more malignant and metastasizing more frequently than SS. Tumor angiogenesis is highly related with tumor progression and metastasis, with microvessel density (MVD being an important parameter of metastatic potential. Canine seminoma is not yet well-established as SE or SS type including correlation with angiogenesis. We classified canine SE and SS, and then compared them to tumor associated vessels. Methods Twenty-three cases of canine seminomas (2 intratubular, 9 diffuse, and 12 intratubular/diffuse seminomas showing both intratubular and diffuse patterns were classified as SE or SS by immunohistochemistry (IHC using monoclonal antibody against PLAP and by PAS stain. The histopathological data were then compared to see if there was a correlation with SE or SS. Angiogenesis of seminomas were evaluated by immunohistochemical assay using polyclonal antibody against Von Willebrand factor (vWF and by calculating the means of MVD, vessels area and perimeters using computerized image analysis. Statistical Package for Social Sciences (SPSS program was used for various statistical analyses. Results The numbers of PLAP+/PAS+ canine SEs were 8/23 (34.8% and PLAP-/PAS- SSs were 15/23 (61.2%. All SE cases (8/8, 100% were intratubular/diffuse types. SS types included 2 intratubular (2/15, 13.3%, 9 diffuse (9/15, 60%, and 4 intratubular/diffuse (4/15, 26.7% types. MVD and vascular parameters in SEs were significantly higher than in SSs, showing the highest value in the intratubular/diffuse type. Seminomas observed with neoplastic cells invasion of vessels presented higher perimeter and area values than seminomas without conformed neoplastic cells invasion. Conclusion In this study, we demonstrated a positive relationship between canine SE and tumor angiogenesis. Furthermore, we also showed that a tumor cells invasion of vessels

  17. Canine classical seminoma: a specific malignant type with human classifications is highly correlated with tumor angiogenesis

    Science.gov (United States)

    2010-01-01

    Background Human seminoma is classified as classical seminoma (SE) and spermatocytic seminoma (SS). Human SE is known to be more malignant and metastasizing more frequently than SS. Tumor angiogenesis is highly related with tumor progression and metastasis, with microvessel density (MVD) being an important parameter of metastatic potential. Canine seminoma is not yet well-established as SE or SS type including correlation with angiogenesis. We classified canine SE and SS, and then compared them to tumor associated vessels. Methods Twenty-three cases of canine seminomas (2 intratubular, 9 diffuse, and 12 intratubular/diffuse seminomas showing both intratubular and diffuse patterns) were classified as SE or SS by immunohistochemistry (IHC) using monoclonal antibody against PLAP and by PAS stain. The histopathological data were then compared to see if there was a correlation with SE or SS. Angiogenesis of seminomas were evaluated by immunohistochemical assay using polyclonal antibody against Von Willebrand factor (vWF) and by calculating the means of MVD, vessels area and perimeters using computerized image analysis. Statistical Package for Social Sciences (SPSS) program was used for various statistical analyses. Results The numbers of PLAP+/PAS+ canine SEs were 8/23 (34.8%) and PLAP-/PAS- SSs were 15/23 (61.2%). All SE cases (8/8, 100%) were intratubular/diffuse types. SS types included 2 intratubular (2/15, 13.3%), 9 diffuse (9/15, 60%), and 4 intratubular/diffuse (4/15, 26.7%) types. MVD and vascular parameters in SEs were significantly higher than in SSs, showing the highest value in the intratubular/diffuse type. Seminomas observed with neoplastic cells invasion of vessels presented higher perimeter and area values than seminomas without conformed neoplastic cells invasion. Conclusion In this study, we demonstrated a positive relationship between canine SE and tumor angiogenesis. Furthermore, we also showed that a tumor cells invasion of vessels were a correlated

  18. Endotoxin levels correlate positively with a sedentary lifestyle and negatively with highly trained subjects.

    Science.gov (United States)

    Lira, Fabio S; Rosa, Jose C; Pimentel, Gustavo D; Souza, Hélio A; Caperuto, Erico C; Carnevali, Luiz C; Seelaender, Marília; Damaso, Ana R; Oyama, Lila M; de Mello, Marco T; Santos, Ronaldo V

    2010-08-04

    A sedentary lifestyle increases the risk of developing cardiovascular disease, obesity, and diabetes. This phenomenon is supported by recent studies suggesting a chronic, low-grade inflammation status. Endotoxin derived from gut flora may be key to the development of inflammation by stimulating the secretion of inflammatory factors. This study aimed to examine plasma inflammatory markers and endotoxin levels in individuals with a sedentary lifestyle and/or in highly trained subjects at rest. Fourteen male subjects (sedentary lifestyle n = 7; highly trained subjects n = 7) were recruited. Blood samples were collected after an overnight fast (approximately 12 h). The plasmatic endotoxin, plasminogen activator inhibitor type-1 (PAI-1), monocyte chemotactic protein-1 (MCP1), ICAM/CD54, VCAM/CD106 and lipid profile levels were determined. Endotoxinemia was lower in the highly trained subject group relative to the sedentary subjects (p < 0.002). In addition, we observed a positive correlation between endotoxin and PAI-1 (r = 0.85, p < 0.0001), endotoxin and total cholesterol (r = 0.65; p < 0.01), endotoxin and LDL-c (r = 0.55; p < 0.049) and endotoxin and TG levels (r = 0.90; p < 0.0001). The plasma levels of MCP-1, ICAM/CD54 and VCAM/CD106 did not differ. These results indicate that a lifestyle associated with high-intensity and high-volume exercise induces favorable changes in chronic low-grade inflammation markers and may reduce the risk for diseases such as obesity, diabetes and cardiovascular diseases.

  19. Correlation between working positions and lactic acid levels with musculoskeletal complaints among dentists

    Directory of Open Access Journals (Sweden)

    Fiory Dioptis Putriwijaya

    2016-12-01

    Full Text Available Background: Musculoskeletal complaints have been common for dentists since their body is unknowingly often in inappropriate positions when caring for patients. For example, they bend towards patients, suddenly move, and then rotate from one side to another. The repetitive movements are done in long term. High activities and sufficient recovery time can cause a buildup of lactic acid in their blood leading to obstruction of the energy intake from the aerobic system in their muscle cells, resulting in fatigue. As a result, such conditions trigger decreased muscle performances. Purpose: This study aimed to determine the correlation between working positions and lactic acid levels with the risk of musculoskeletal disorders among dentists at Public Health Centers in Surabaya. Method: This research was an analytical observational research using cross sectional approach. Sampling technique used in this research was cluster random sampling with nineteen samples. To evaluate the working positions of those samples, a rapid entire body assessment (REBA method was used. Meanwhile, to observe the musculoskeletal disorders of those samples, a Nordic body map was used. Data obtained then were analyzed using Pearson correlation test with a significance level (p<0.05. Result: Results of data analysis using the Pearson correlation test showed that the significance value obtained was 0.036. It indicates that there was a correlation between the working positions and the lactic acid levels with the musculoskeletal disorders in those dentists. The results of the Pearson correlation test also revealed that there was a correlation between the working positions and the lactic acid levels among those dentists with a significance value of 0.025. Conclusion: It may be concluded that the wrong body positions during working can increase lactic acid level in the body of dentists. The increased level of lactic acid then can affect their muscles, leading to the high risk of

  20. Correlation analysis of high-risk human papillomavirus viral load and cervical lesions

    Directory of Open Access Journals (Sweden)

    Xiao-xing MA

    2012-05-01

    Full Text Available Objective  To explore the association between high-risk human papillomavirus (HR-HPV viral load and pathological grades of cervical intraepithelial neoplasia (CIN and cervical cancer. Methods  A total of 1248 patients from General Hospital of PLA, who underwent colposcopy and surgery due to cervical lesions between Jan. 2006 and Aug. 2011 were enrolled in this study, and they were divided five groups: cervicitis, CIN Ⅰ, CIN Ⅱ-Ⅲ, stage Ⅰ cervical cancer and stage Ⅱ cervical cancer. HR-HPV viral load (RLU/CO was determined by the Hybrid Capture Ⅱ (HCⅡ system, and they were categorized into five groups: 0-0.99, 1.00-9.99, 10.00-99.99, 100.00-999.99, ≥1000.00. The mean value and standard deviation of different HR-HPV viral load in the patients with cervicitis or with CIN Ⅰ, CINⅡ-Ⅲ, stage Ⅰ cervical cancer or stage Ⅱ cervical cancer were compared, and the correlation of HR-HPV viral load and pathogenesis of cervical lesions was analyzed. Results  HPV viral loads were significantly higher in CINⅠ(842.1±983.9, CINⅡ-Ⅲ (690.1±795.0, stage Ⅰ cervical cancer (893.1±974.2 and stage Ⅱ cervical cancer (699.5±908.3 patients than in cervicitis patients (274.2±613.6, P < 0.05, and the HPV viral loads in CINⅠ(842.1±983.9 and stage Ⅰ cervical cancer patients were higher than those in CINⅡ-Ⅲ patients (P < 0.05. When HR-HPV viral load was ≥100RLU/CO, the risk of CIN and cervical cancer increased with the increase in viral load, but there was no correlation between the viral load and pathological grades of cervical lesions. In the patients with stage ⅠB-Ⅱ cervical squamous cell carcinoma, when the HR-HPV viral load was ≥100RLU/CO, the risk of lymph node metastasis increased (P < 0.05, and the number of patients with maximum diameter of the cervical tumor ≥4cm also increased (P < 0.05. However, the HR-HPV viral load was not correlated with patient age, pathological type of the lesion, depth of cancer

  1. High-speed 3D digital image correlation vibration measurement: Recent advancements and noted limitations

    Science.gov (United States)

    Beberniss, Timothy J.; Ehrhardt, David A.

    2017-03-01

    A review of the extensive studies on the feasibility and practicality of utilizing high-speed 3 dimensional digital image correlation (3D-DIC) for various random vibration measurement applications is presented. Demonstrated capabilities include finite element model updating utilizing full-field 3D-DIC static displacements, modal survey natural frequencies, damping, and mode shape results from 3D-DIC are baselined against laser Doppler vibrometry (LDV), a comparison between foil strain gage and 3D-DIC strain, and finally the unique application to a high-speed wind tunnel fluid-structure interaction study. Results show good agreement between 3D-DIC and more traditional vibration measurement techniques. Unfortunately, 3D-DIC vibration measurement is not without its limitations, which are also identified and explored in this study. The out-of-plane sensitivity required for vibration measurement for 3D-DIC is orders of magnitude less than LDV making higher frequency displacements difficult to sense. Furthermore, the digital cameras used to capture the DIC images have no filter to eliminate temporal aliasing of the digitized signal. Ultimately DIC is demonstrated as a valid alternative means to measure structural vibrations while one unique application achieves success where more traditional methods would fail.

  2. Profumo di SUSY: Suggestive Correlations in the ATLAS and CMS High Jet Multiplicity Data

    CERN Document Server

    Li, Tianjun; Nanopoulos, Dimitri V; Walker, Joel W

    2011-01-01

    We present persistently amassing evidence that the CMS and ATLAS Collaborations may indeed be already registering supersymmetry events at the Large Hadron Collider (LHC). Our analysis is performed in the context of a highly phenomenologically favorable model named No-Scale F-SU(5), which represents the unification of the F-lipped SU(5) Grand Unified Theory (GUT), two pairs of hypothetical TeV-scale vector-like supersymmetric multiplets derived out of F-Theory, and the dynamically established boundary conditions of No-Scale supergravity. We document highly suggestive correlations between the first inverse femtobarn of observations by CMS and ATLAS, where seductive excesses in multijet events, particularly those with nine or more jets, are unambiguously accounted for by a precision Monte-Carlo simulation of the F-SU(5) model space. This intimate correspondence is optimized by a unified gaugino mass in the neighborhood of M_{1/2}=518 GeV. We supplement this analysis by extrapolating for the expected data profile...

  3. Histopathology reveals correlative and unique phenotypes in a high-throughput mouse phenotyping screen

    Directory of Open Access Journals (Sweden)

    Hibret A. Adissu

    2014-05-01

    Full Text Available The Mouse Genetics Project (MGP at the Wellcome Trust Sanger Institute aims to generate and phenotype over 800 genetically modified mouse lines over the next 5 years to gain a better understanding of mammalian gene function and provide an invaluable resource to the scientific community for follow-up studies. Phenotyping includes the generation of a standardized biobank of paraffin-embedded tissues for each mouse line, but histopathology is not routinely performed. In collaboration with the Pathology Core of the Centre for Modeling Human Disease (CMHD we report the utility of histopathology in a high-throughput primary phenotyping screen. Histopathology was assessed in an unbiased selection of 50 mouse lines with (n=30 or without (n=20 clinical phenotypes detected by the standard MGP primary phenotyping screen. Our findings revealed that histopathology added correlating morphological data in 19 of 30 lines (63.3% in which the primary screen detected a phenotype. In addition, seven of the 50 lines (14% presented significant histopathology findings that were not associated with or predicted by the standard primary screen. Three of these seven lines had no clinical phenotype detected by the standard primary screen. Incidental and strain-associated background lesions were present in all mutant lines with good concordance to wild-type controls. These findings demonstrate the complementary and unique contribution of histopathology to high-throughput primary phenotyping of mutant mice.

  4. Chloroplast movement behavior varies widely among species and does not correlate with high light stress tolerance.

    Science.gov (United States)

    Königer, Martina; Bollinger, Nicole

    2012-08-01

    It is well known that chloroplasts move in response to changes in blue light intensity in order to optimize light interception, however, little is known about interspecific variation and the relative importance of this mechanism for the high light stress tolerance of plants. We characterized chloroplast movement behavior as changes in light transmission through a leaf in a variety of species ranging from ferns to monocots and eudicots and found a wide spectrum of responses. Most species exhibited a distinct accumulation response compared to the dark positioning, and all species showed a distinct avoidance response. The speed with which transmission values changed during the avoidance response was consistently faster than that during the accumulation response and speeds varied greatly between species. Plants thriving in higher growth light intensities showed greater degrees of accumulation responses and faster changes in transmission than those that prefer lower light intensities. In some species, the chloroplasts on both the adaxial and abaxial leaf surfaces changed their positioning in response to light, while in other species only the chloroplasts on one leaf side responded. No correlation was found between high light stress tolerance and the speed or degree of transmission changes, indicating that plants can compensate for slow and limited transmission changes using other photoprotective mechanisms.

  5. Histopathology reveals correlative and unique phenotypes in a high-throughput mouse phenotyping screen.

    Science.gov (United States)

    Adissu, Hibret A; Estabel, Jeanne; Sunter, David; Tuck, Elizabeth; Hooks, Yvette; Carragher, Damian M; Clarke, Kay; Karp, Natasha A; Newbigging, Susan; Jones, Nora; Morikawa, Lily; White, Jacqueline K; McKerlie, Colin

    2014-05-01

    The Mouse Genetics Project (MGP) at the Wellcome Trust Sanger Institute aims to generate and phenotype over 800 genetically modified mouse lines over the next 5 years to gain a better understanding of mammalian gene function and provide an invaluable resource to the scientific community for follow-up studies. Phenotyping includes the generation of a standardized biobank of paraffin-embedded tissues for each mouse line, but histopathology is not routinely performed. In collaboration with the Pathology Core of the Centre for Modeling Human Disease (CMHD) we report the utility of histopathology in a high-throughput primary phenotyping screen. Histopathology was assessed in an unbiased selection of 50 mouse lines with (n=30) or without (n=20) clinical phenotypes detected by the standard MGP primary phenotyping screen. Our findings revealed that histopathology added correlating morphological data in 19 of 30 lines (63.3%) in which the primary screen detected a phenotype. In addition, seven of the 50 lines (14%) presented significant histopathology findings that were not associated with or predicted by the standard primary screen. Three of these seven lines had no clinical phenotype detected by the standard primary screen. Incidental and strain-associated background lesions were present in all mutant lines with good concordance to wild-type controls. These findings demonstrate the complementary and unique contribution of histopathology to high-throughput primary phenotyping of mutant mice.

  6. Approximations to complete basis set-extrapolated, highly correlated non-covalent interaction energies

    Science.gov (United States)

    Mackie, Iain D.; DiLabio, Gino A.

    2011-10-01

    The first-principles calculation of non-covalent (particularly dispersion) interactions between molecules is a considerable challenge. In this work we studied the binding energies for ten small non-covalently bonded dimers with several combinations of correlation methods (MP2, coupled-cluster single double, coupled-cluster single double (triple) (CCSD(T))), correlation-consistent basis sets (aug-cc-pVXZ, X = D, T, Q), two-point complete basis set energy extrapolations, and counterpoise corrections. For this work, complete basis set results were estimated from averaged counterpoise and non-counterpoise-corrected CCSD(T) binding energies obtained from extrapolations with aug-cc-pVQZ and aug-cc-pVTZ basis sets. It is demonstrated that, in almost all cases, binding energies converge more rapidly to the basis set limit by averaging the counterpoise and non-counterpoise corrected values than by using either counterpoise or non-counterpoise methods alone. Examination of the effect of basis set size and electron correlation shows that the triples contribution to the CCSD(T) binding energies is fairly constant with the basis set size, with a slight underestimation with CCSD(T)/aug-cc-pVDZ compared to the value at the (estimated) complete basis set limit, and that contributions to the binding energies obtained by MP2 generally overestimate the analogous CCSD(T) contributions. Taking these factors together, we conclude that the binding energies for non-covalently bonded systems can be accurately determined using a composite method that combines CCSD(T)/aug-cc-pVDZ with energy corrections obtained using basis set extrapolated MP2 (utilizing aug-cc-pVQZ and aug-cc-pVTZ basis sets), if all of the components are obtained by averaging the counterpoise and non-counterpoise energies. With such an approach, binding energies for the set of ten dimers are predicted with a mean absolute deviation of 0.02 kcal/mol, a maximum absolute deviation of 0.05 kcal/mol, and a mean percent

  7. High Statistics Analysis using Anisotropic Clover Lattices: (I) Single Hadron Correlation Functions

    Energy Technology Data Exchange (ETDEWEB)

    Will Detmold,Konstantinos Orginos,Silas R. Beane,Will Detmold,William Detmold,Thomas C. Luu,Konstantinos Orginos,Assumpta Parreno,Martin J. Savage,Aaron Torok,Andre Walker-Loud

    2009-06-01

    We present the results of high-statistics calculations of correlation functions generated with single-baryon interpolating operators on an ensemble of dynamical anisotropic gauge-field configurations generated by the Hadron Spectrum Collaboration using a tadpole-improved clover fermion action and Symanzik-improved gauge action. A total of 292,500 sets of measurements are made using 1194 gauge configurations of size 20^3 x 128 with an anisotropy parameter \\xi= b_s/b_t = 3.5, a spatial lattice spacing of b_s=0.1227\\pm 0.0008 fm, and pion mass of m_\\pi ~ 390 MeV. Ground state baryon masses are extracted with fully quantified uncertainties that are at or below the ~0.2%-level in lattice units. The lowest-lying negative-parity states are also extracted albeit with a somewhat lower level of precision. In the case of the nucleon, this negative-parity state is above the N\\pi threshold and, therefore, the isospin-1/2 \\pi N s-wave scattering phase-shift can be extracted using Luescher's method. The disconnected contributions to this process are included indirectly in the gauge-field configurations and do not require additional calculations. The signal-to-noise ratio in the various correlation functions is explored and is found to degrade exponentially faster than naive expectations on many time-slices. This is due to backward propagating states arising from the anti-periodic boundary conditions imposed on the quark-propagators in the time-direction. We explore how best to distribute computational resources between configuration generation and propagator measurements in order to optimize the extraction of single baryon observables.

  8. High Statistics Analysis using Anisotropic Clover Lattices: (I) Single Hadron Correlation Functions

    Energy Technology Data Exchange (ETDEWEB)

    Beane, S; Detmold, W; Luu, T; Orginos, K; Parreno, A; Savage, M; Torok, A; Walker-Loud, A

    2009-03-23

    We present the results of high-statistics calculations of correlation functions generated with single-baryon interpolating operators on an ensemble of dynamical anisotropic gauge-field configurations generated by the Hadron Spectrum Collaboration using a tadpole-improved clover fermion action and Symanzik-improved gauge action. A total of 292, 500 sets of measurements are made using 1194 gauge configurations of size 20{sup 3} x 128 with an anisotropy parameter {zeta} = b{sub s}/b{sub t} = 3.5, a spatial lattice spacing of b{sub s} = 0.1227 {+-} 0.0008 fm, and pion mass of M{sub {pi}} {approx} 390 MeV. Ground state baryons masses are extracted with fully quantified uncertainties that are at or below the {approx} 0.2%-level in lattice units. The lowest-lying negative-parity states are also extracted albeit with a somewhat lower level of precision. In the case of the nucleon, this negative-parity state is above the N{pi} threshold and, therefore, the isospin-1/2 {pi}N s-wave scattering phase-shift can be extracted using Luescher's method. The disconnected contributions to this process are included indirectly in the gauge-field configurations and do not require additional calculations. The signal-to-noise ratio in the various correlation functions is explored and is found to degrade exponentially faster than naive expectations on many time-slices. This is due to backward propagating states arising from the anti-periodic boundary conditions imposed on the quark-propagators in the time-direction. We explore how best to distribute computational resources between configuration generation and propagator measurements in order to optimize the extraction of single baryon observables.

  9. Depolarized Photon Correlation Spectroscopic Study of the Glass-Forming Liquid Cumene at Very High Pressures

    Science.gov (United States)

    Lyon, Kevin; Ransom, Tim; Oliver, William

    2014-03-01

    In recent years full-spectrum analysis of light-scattering data has been utilized to explore the liquid-glass transition at variable temperatures and ambient pressure. We have developed methods for doing depolarized photon correlation spectroscopy (PCS) in the diamond anvil cell in order to probe directly the structural relaxation time of glass-forming liquids at very high pressures. Here we present results for liquid cumene at 25 C between 1 bar and pressures approaching the room-temperature glass transition at 2.1 GPa. Data along higher-temperature isotherms will also be presented. Methods for minimizing any undesired heterodyne component in the collected light as well as the use of the longitudinal modes of the Brillouin spectrum to aid in the acquisition and spatial filtering of the scattered light will be discussed. Intensity-intensity correlation data were found to be well represented by the KWW equation with a nearly constant stretching parameter of g = 0.66 for 25 C. Furthermore, the relaxation time as a function of pressure is described will using a modified VTF expression: (P)=0exp{DP/(P0-P)}, with values of 0 = 11.9 ps, D = 18.6, and P0 = 3.4 GPa at T = 25 °C. Thus, (P) has been obtained at 25 °C for Cumene over seven decades from about a microsecond to several seconds and is found to be in excellent agreement with previously determined values for the alpha relaxation at lower pressures obtained from Brillouin data [G. Li, et al., Phys. Rev. Lett. 74, 2280 (1995)]. Partially supported by NSF Grant Number: DMR 0552944.

  10. Back-to-back correlations of high-p(T) hadrons in relativistic heavy-ion collisions.

    Science.gov (United States)

    Hirano, Tetsufumi; Nara, Yasushi

    2003-08-22

    We investigate the suppression factor and the azimuthal correlation function for high p(T) hadrons in central Au+Au collisions at sqrt[s(NN)]=200 GeV by using a dynamical model in which hydrodynamics is combined with explicitly traveling jets. We study the effects of parton energy loss in a hot medium, intrinsic k(T) of partons in a nucleus, and p (perpendicular) broadening of jets on the back-to-back correlations of high p(T) hadrons. Parton energy loss is found to be a dominant effect on the reduction of the awayside peaks in the correlation function.

  11. Strongly correlated electrons at high pressure: an approach by inelastic X-Ray scattering; Electrons correles sous haute pression: une approche par diffusion inelastique des rayons X

    Energy Technology Data Exchange (ETDEWEB)

    Rueff, J.P

    2007-06-15

    Inelastic X-ray scattering (IXS) and associated methods has turn out to be a powerful alternative for high-pressure physics. It is an all-photon technique fully compatible with high-pressure environments and applicable to a vast range of materials. Standard focalization of X-ray in the range of 100 microns is typical of the sample size in the pressure cell. Our main aim is to provide an overview of experimental results obtained by IXS under high pressure in 2 classes of materials which have been at the origin of the renewal of condensed matter physics: strongly correlated transition metal oxides and rare-earth compounds. Under pressure, d and f-electron materials show behaviors far more complex that what would be expected from a simplistic band picture of electron delocalization. These spectroscopic studies have revealed unusual phenomena in the electronic degrees of freedom, brought up by the increased density, the changes in the charge-carrier concentration, the over-lapping between orbitals, and hybridization under high pressure conditions. Particularly we discuss about pressure induced magnetic collapse and metal-insulator transitions in 3d compounds and valence fluctuations phenomena in 4f and 5f compounds. Thanks to its superior penetration depth, chemical selectivity and resonant enhancement, resonant inelastic X-ray scattering has appeared extremely well suited to high pressure physics in strongly correlated materials. (A.C.)

  12. High Avidity dsDNA Autoantibodies in Brazilian Women with Systemic Lupus Erythematosus: Correlation with Active Disease and Renal Dysfunction

    Directory of Open Access Journals (Sweden)

    Rodrigo C. Oliveira

    2015-01-01

    Full Text Available We investigated in Brazilian women with SLE the prevalence and levels of high avidity (HA dsDNA antibodies and tested their correlation with lupus activity and biomarkers of renal disease. We also compared these correlations to those observed with total dsDNA antibodies and antibodies against nucleosome (ANuA. Autoantibodies were detected by ELISA, while C3 and C4 levels were determined by nephelometry. Urine protein/creatinine ratio was determined, and lupus activity was measured by SLEDAI-2K. The prevalence of total and HA dsDNA antibodies was similar to but lower than that verified for ANuA. The levels of the three types of antibodies were correlated, but the correlation was more significant between HA dsDNA antibodies and ANuA. High avidity dsDNA antibodies correlated positively with ESR and SLEDAI and inversely with C3 and C4. Similar correlations were observed for ANuA levels, whereas total dsDNA antibodies only correlated with SLEDAI and C3. The levels of HA dsDNA antibodies were higher in patients with proteinuria, but their levels of total dsDNA antibodies and ANuA were unaltered. High avidity dsDNA antibodies can be found in high prevalence in Brazilian women with SLE and are important biomarkers of active disease and kidney dysfunction.

  13. Clustering stocks using partial correlation coefficients

    Science.gov (United States)

    Jung, Sean S.; Chang, Woojin

    2016-11-01

    A partial correlation analysis is performed on the Korean stock market (KOSPI). The difference between Pearson correlation and the partial correlation is analyzed and it is found that when conditioned on the market return, Pearson correlation coefficients are generally greater than those of the partial correlation, which implies that the market return tends to drive up the correlation between stock returns. A clustering analysis is then performed to study the market structure given by the partial correlation analysis and the members of the clusters are compared with the Global Industry Classification Standard (GICS). The initial hypothesis is that the firms in the same GICS sector are clustered together since they are in a similar business and environment. However, the result is inconsistent with the hypothesis and most clusters are a mix of multiple sectors suggesting that the traditional approach of using sectors to determine the proximity between stocks may not be sufficient enough to diversify a portfolio.

  14. Microwave Imaging Sensor Using Compact Metamaterial UWB Antenna with a High Correlation Factor

    Directory of Open Access Journals (Sweden)

    Md. Moinul Islam

    2015-07-01

    Full Text Available The design of a compact metamaterial ultra-wideband (UWB antenna with a goal towards application in microwave imaging systems for detecting unwanted cells in human tissue, such as in cases of breast cancer, heart failure and brain stroke detection is proposed. This proposed UWB antenna is made of four metamaterial unit cells, where each cell is an integration of a modified split ring resonator (SRR, capacitive loaded strip (CLS and wire, to attain a design layout that simultaneously exhibits both a negative magnetic permeability and a negative electrical permittivity. This design results in an astonishing negative refractive index that enables amplification of the radiated power of this reported antenna, and therefore, high antenna performance. A low-cost FR4 substrate material is used to design and print this reported antenna, and has the following characteristics: thickness of 1.6 mm, relative permeability of one, relative permittivity of 4.60 and loss tangent of 0.02. The overall antenna size is 19.36 mm × 27.72 mm × 1.6 mm where the electrical dimension is 0.20 λ × 0.28 λ × 0.016 λ at the 3.05 GHz lower frequency band. Voltage Standing Wave Ratio (VSWR measurements have illustrated that this antenna exhibits an impedance bandwidth from 3.05 GHz to more than 15 GHz for VSWR < 2 with an average gain of 4.38 dBi throughout the operating frequency band. The simulations (both HFSS and computer simulation technology (CST and the measurements are in high agreement. A high correlation factor and the capability of detecting tumour simulants confirm that this reported UWB antenna can be used as an imaging sensor.

  15. Disordered Eating Attitudes and Their Correlates among Iranian High School Girls

    Directory of Open Access Journals (Sweden)

    Mahdiyeh Hamed Behzad

    2011-07-01

    Full Text Available Background: Disordered eating attitudes are contributing factors to the development of eatingdisorders. Adolescent girls are at high risk for eating diseases. In Iran, there is few data onthe subject, especially in Azarian adolescent girls, so we did this study for assessing disorderedeating attitudes and their correlates among Iranian Azarbaijani high school girls.Methods: In a cross-sectional study, 1887 high school girls were selected. Eating AttitudeTest-26 (EAT-26 and socio economical questionnaires were used. The EAT-26 score of 20or higher defined as disordered eating attitudes. Data were analyzed using the Statistical Programfor Social Sciences, by using from descriptive and analytical statistics.Results: Reliability and validity of the translated EAT-26 were 0.80, 0.76, respectively. Instudied subjects, mean (SD of EAT-26 was 11.71(8.48. Totally, 16.7% (C.I with 95%: 15.1-18.3% of students had disordered eating attitudes. About half of the participants were unhappywith their body weight and considered themselves as obese. Mean of EAT-26 washigher in this group. Groups, who intent to weight loss, were smoker, and who had age ofmenarche less than 11 years, also had higher EAT-26 scores. Parent’s literacy or job, birthorder, family size or income and house ownership had not any significant effect on EAT-26score.Conclusions: Persian version of EAT-26 has good reliability and validity for assessing disorderedeating attitudes in Azarian girl adolescents. Prevalence of disordered eating attitudesamong Azarian adolescent girls are in the range of some studies, but are less than Arabiancountries, and some European ones. In adolescent girls, body weight dissatisfaction, smokingand early menarche has important role in eating attitudes.

  16. Emergent high-Tc ferroelectric ordering of strongly correlated and frustrated protons in a heteroepitaxial ice film

    Science.gov (United States)

    Sugimoto, Toshiki; Aiga, Norihiro; Otsuki, Yuji; Watanabe, Kazuya; Matsumoto, Yoshiyasu

    2016-11-01

    Materials containing strong correlation and frustration have the potential to respond to external perturbations in an unusual way. In the case of common water ice, protons in the hydrogen-bond network are strongly correlated and highly frustrated under Pauling's ice rules. At low temperature, the strongly correlated protons lose ergodicity, and little is understood about the cooperative thermodynamic and electric response to external stimuli. Here, using a model platinum substrate, we demonstrate emergent high-Tc ferroelectric proton ordering in a heteroepitaxial ice film. Such proton ordering is thermodynamically stable and has an extremely high critical temperature of ~175 K. We found that anisotropy and protolysis driven by the electrostatistics at the heterointerface are key factors in stimulating this novel exotic ordering in the many-body correlated proton system. The significant increase in Tc due to the heterointerface suggests the ubiquity of ferroelectric ice in nature--specifically, in space and the polar stratosphere.

  17. Components of ongoing EEG with high correlation point to emotionally-laden attention -- a possible marker of engagement?

    Directory of Open Access Journals (Sweden)

    Jacek P Dmochowski

    2012-05-01

    Full Text Available Recent evidence from functional magnetic resonance imaging suggests that cortical hemodynamic responses coincide in different subjects experiencing a common naturalistic stimulus. Here we utilize neural responses in the electroencephalogram (EEG evoked by multiple presentations of short film clips to index brain states marked by high levels of correlation within and across subjects. We formulate a novel signal decomposition method which extracts maximally correlated signal components from multiple EEG records. The resulting components capture correlations down to a one-second time resolution, thus revealing that peak correlations of neural activity across viewings can occur in remarkable correspondence with arousing moments of the film. Moreover, a significant reduction in neural correlation occurs upon a second viewing of the film or when the narrative is disrupted by presenting its scenes scrambled in time. We also probe oscillatory brain activity during periods of heightened correlation, and observe during such times a significant increase in the theta-band for a frontal component and reductions in the alpha and beta frequency bands for parietal and occipital components. Low-resolution EEG tomography of these components suggests that the correlated neural activity is consistent with sources in the cingulate and orbitofrontal cortices. Put together, these results suggest that the observed synchrony reflects attention- and emotion-modulated cortical processing, and that naturalistic brain states such as engagement may be decoded with high temporal resolution by extracting maximally correlated components of neural activity.

  18. Spatial correlation of radar and gauge precipitation data in high temporal resolution

    Directory of Open Access Journals (Sweden)

    J. Brommundt

    2007-01-01

    Full Text Available A multi-sites precipitation time series generator for engineering designs is currently being developed. The objective is to generate several time series' simultaneously with correct inter-station relationships. Therefore, a model to estimate correlation between stations for arbitrary points in a project area is needed, using rain gauge data as well as radar data. Two methods are applied to compare the spatial behaviour of precipitation in both the rain gauge data and the radar data. The first approach is to calculate precipitation intensities from radar reflectivity and use it as gauge data. The results show that the spatial structure in both data sets is similar, but cross correlation varies too much to use radar derived spatial correlation to describe gauge inter-station relationship. Thus, a second approach was tested to account for the differences in the spatial correlation associated to the distribution. Using the indicator time series, cross correlations for different quantiles were calculated from both the rain gauge and radar data. This approach shows that cross correlation varies depending on the chosen quantile. In the lower quantiles, the correlation is very similar in rain gauge and radar data, hence a transfer is possible. This insight is useful to derive cross correlations of rain gauges from radar images. Correlation data for rain gauges thus obtained contains all the information about heterogeneity and anisotropy of the spatial structure of rainfall, which is in the radar data.

  19. Correlation between centrality metrics and their application to the opinion model

    CERN Document Server

    Li, Cong; Van Mieghem, Piet; Stanley, H Eugene; Wang, Huijuan

    2014-01-01

    In recent decades, a number of centrality metrics describing network properties of nodes have been proposed to rank the importance of nodes. In order to understand the correlations between centrality metrics and to approximate a high-complexity centrality metric by a strongly correlated low-complexity metric, we ?first study the correlation between centrality metrics in terms of their Pearson correlation coefficient and their similarity in ranking of nodes. In addition to considering the widely used centrality metrics, we introduce a new centrality measure, the degree mass. The m order degree mass of a node is the sum of the weighted degree of the node and its neighbors no further than m hops away. We find that the B_{n}, the closeness, and the components of x_{1} are strongly correlated with the degree, the 1st-order degree mass and the 2nd-order degree mass, respectively, in both network models and real-world networks. We then theoretically prove that the Pearson correlation coefficient between x_{1} and th...

  20. HIV Prevalence Correlates with High-Risk Sexual Behavior in Ethiopia's Regions

    Science.gov (United States)

    Kenyon, Chris R.; Tsoumanis, Achilleas; Schwartz, Ilan Steven

    2015-01-01

    Background HIV prevalence varies between 0.9 and 6.5% in Ethiopia’s eleven regions. Little has been published examining the reasons for this variation. Methods We evaluated the relationship between HIV prevalence by region and a range of risk factors in the 2005 and 2011 Ethiopian Demographic Health Surveys. Pearson’s correlation was used to assess the relationship between HIV prevalence and each variable. Results There was a strong association between HIV prevalence and three markers of sexual risk: mean lifetime number of partners (men: r = 0.87; P cohabiting partner (men: r = 0.92; P premarital sex. Condom usage and HIV testing were positively associated with HIV prevalence, while the prevalence of circumcision, polygamy, age at sexual debut and male migration were not associated with HIV prevalence. Conclusion Variation in sexual behavior may contribute to the large variations in HIV prevalence by region in Ethiopia. Population-level interventions to reduce risky sexual behavior in high HIV incidence regions should be considered. PMID:26496073

  1. Pion correlations and calorimeter design for high energy heavy ion collisions. Progress report

    Energy Technology Data Exchange (ETDEWEB)

    Wolf, K.L.

    1997-04-01

    Data analysis is in progress for recent experiments performed by the NA44 collaboration with the first running of 160 A GeV {sup 208}Pb-induced reactions at the CERN SPS. Identified singles spectra were taken for pions, kaons, protons, deuterons, antiprotons and antideuterons. Two-pion interferometry measurements were made for semi-central-triggered {sup 208}Pb + Pb collisions. An updated multi-particle spectrometer allows high statistics data sets of identified particles to be collected near mid-rapidity. A second series of experiments will be performed in the fall of 1995 with more emphasis on identical kaon interferometry and on the measurement of rare particle spectra and correlations. Modest instrumentation upgrades by TAMU are designed to increase the trigger function for better impact parameter selection and improved collection efficiency of valid events. An effort to achieve the highest degree of projectile-target stopping is outlined and it is argued that an excitation function on the SPS is needed to better understand reaction mechanisms. Analysis of experimental results is in the final stages at LBL in the EOS collaboration for two-pion interferometry in the 1.2 A GeV Au + Au reaction, taken with full event characterization.

  2. Pion and kaon correlations in high energy heavy-ion collisions

    Energy Technology Data Exchange (ETDEWEB)

    Wolf, K.L.; Wolf, K.L.

    1996-12-31

    Data analysis is in progress for recent experiments performed by the NA44 collaboration with the first running of 160 A GeV {sup 208}Pb-induced reactions at the CERN SPS. Identified singles spectra were taken for pions, kaons, protons, deuterons, antiprotons and antideuterons. Two-pion interferometry measurements were made for semi-central-triggered {sup 208}Pb + Pb collisions. An upgraded multi-particle spectrometer allows high statistics data sets of identified particles to be collected near mid-rapidity. A second series of experiments will be performed in the fall of 1995 with more emphasis on identical kaon interferometry and on the measurement of rare particle spectra and correlations. Modest instrumentation upgrades by TAMU are designed to increase the trigger function for better impact parameter selection and improved collection efficiency of valid events. An effort to achieve the highest degree of projectile-target stopping is outlined and it is argued that an excitation function on the SPS is needed to better understand reaction mechanisms. Analysis of experimental results is in the final stages at LBL in the EOS collaboration for two-pion interferometry in the 1.2 A GeV Au+Au reaction, taken with full event characterization. 35 refs., 15 figs., 5 tabs.

  3. High Statistics Analysis using Anisotropic Clover Lattices: (I) Single Hadron Correlation Functions

    Energy Technology Data Exchange (ETDEWEB)

    Detmold, Will; Detmold, William; Orginos, Konstantinos; R. Beane, Silas; C. Luu, Thomas; Parreno, Assumpta; J. Savage, Martin; Torok, Aaron; Walker-Loud, Andre

    2009-01-01

    We present the results of high-statistics calculations of correlation functions generated with single-baryon interpolating operators on an ensemble of dynamical anisotropic gauge-field configurations generated by the Hadron Spectrum Collaboration using a tadpole-improved clover fermion action and Symanzik-improved gauge action. A total of $\\Nprops$ sets of measurements are made using $\\Ncfgs$ gauge configurations of size $20^3\\times 128$ with an anisotropy parameter $\\xi= b_s/b_t = 3.5$, a spatial lattice spacing of $b_s=0.1227\\pm 0.0008~{\\rm fm}$, and pion mass of $\\mpi\\sim 390~{\\rm MeV}$. Ground state baryons masses are extracted with fully quantified uncertainties that are at or below the $\\sim 0.2\\%$-level in lattice units. The lowest-lying negative-parity states are also extracted albeit with a somewhat lower level of precision. In the case of the nucleon, this negative-parity state is above the $N\\pi$ threshold and, therefore, the isos

  4. A high throughput and sensitive method correlates neuronal disorder genotypes to Drosophila larvae crawling phenotypes.

    Science.gov (United States)

    Jakubowski, Brandon R; Longoria, Rafael A; Shubeita, George T

    2012-01-01

    Drosophila melanogaster is widely used as a model system for development and disease. Due to the homology between Drosophila and human genes, as well as the tractable genetics of the fly, its use as a model for neurologic disorders, in particular, has been rising. Locomotive impairment is a commonly used diagnostic for screening and characterization of these models, yet a fast, sensitive and model-free method to compare behavior is lacking. Here, we present a high throughput method to quantify the crawling behavior of larvae. We use the mean squared displacement as well as the direction autocorrelation of the crawling larvae as descriptors of their motion. By tracking larvae from wild-type strains and models of the Fragile X mental retardation as well as Alzheimer disease, we show these mutants exhibit impaired crawling. We further show that the magnitude of impairment correlates with the severity of the mutation, demonstrating the sensitivity and the dynamic range of the method. Finally, we study larvae with altered expression of the shaggy gene, a homolog of Glycogen Synthase Kinase-3 (GSK-3), which has been implicated in Alzheimer disease. Surprisingly, we find that both increased and decreased expression of dGSK-3 lead to similar larval crawling impairment. These findings have implications for the use of GSK-3 inhibitors recently proposed for Alzheimer treatment.

  5. High phosphorylase activity is correlated with increased potato minituber formation and starch content during extended clinorotation

    Science.gov (United States)

    Nedukha, O. M.; Schnyukova, E. I.; Leach, J. E.

    2003-05-01

    The major purpose of these experiments were to investigate growth of potato storage organs and starch synthesis in minitubers at slow horizontal clinorotation (2 rpm), which partly mimics microgravity, and a secondary goal was to study the activity and localization of phosphorylase (EC 2.4.1.1) in storage parenchyma under these conditions. Miniplants of Solanum tuberosum L. (cv Adreta) were grown in culture for 30 days for both the vertical control and the horizontal clinorotation. During long-term clinorotation, an acceleration of minituber formation, and an increase of amyloplast number and size in storage parenchyma cells, as well as increased starch content, was observed in the minitubers. The differences among cytochemical reaction intensity, activity of phosphorylase, and carbohydrate content in storage parenchyma cells of minitubers grown in a horizontal clinostat were established by electron-cytochemical and biochemical methods. It is shown that high phosphorylase activity is correlated with increased starch content during extended clinorotation. The results demonstrate the increase in carbohydrate metabolism and possible accelerated growth of storage organs under the influence of microgravity, as mimicked by clinorotation; therefore, clinorotation can be used as a basis for future studies on mechanisms of starch synthesis under microgravity.

  6. High expression of FOXR2 in breast cancer correlates with poor prognosis.

    Science.gov (United States)

    Song, Haiping; He, Wenshan; Huang, Xiaoqing; Zhang, Huiqiong; Huang, Tao

    2016-05-01

    Forkhead box protein R2 (FOXR2) is associated with human central nervous system neoplasms. However, the expression level of FOXR2 in breast cancer specimens remains largely unknown. To identify whether FOXR2 can serve as a biomarker for the diagnosis and prognosis of breast cancer, real-time PCR and immunohistochemistry (IHC) staining were utilized to detect the expression of FOXR2. The messenger RNA (mRNA) and protein levels of FOXR2 in breast cancer samples were novelty higher compared to non-tumorous breast tissues. IHC results revealed FOXR2 expression was significantly correlated to classifications tumor size (p = 0.007) and Ki-67 (p = 0.019). The patients with high expression of FOXR2 had a significantly poor prognosis compared to those of low expression (p = 0.003), especially in the patients with tumor size ≥2 cm (p = 0.006) and lymph node metastasis status (p = 0.004). Furthermore, multivariate analysis indicated that FOXR2 expression was an independent prognostic factor for breast cancer patients (p = 0.035). This study first identifies that FOXR2 may be an important molecular marker for diagnosis and prognosis of breast cancer.

  7. Investigations of high-speed optical transmission systems employing Absolute Added Correlative Coding (AACC)

    Science.gov (United States)

    Dong-Nhat, Nguyen; Elsherif, Mohamed A.; Malekmohammadi, Amin

    2016-07-01

    A novel multilevel modulation format based on partial-response signaling called Absolute Added Correlative Coding (AACC) is proposed and numerically demonstrated for high-speed fiber-optic communication systems. A bit error rate (BER) estimation model for the proposed multilevel format has also been developed. The performance of AACC is examined and compared against other prevailing On-Off-Keying and multilevel modulation formats e.g. non-return-to-zero (NRZ), 50% return-to-zero (RZ), 67% carrier-suppressed return-to-zero (CS-RZ), duobinary and four-level pulse-amplitude modulation (4-PAM) in terms of receiver sensitivity, spectral efficiency and dispersion tolerance. Calculated receiver sensitivity at a BER of 10-9 and chromatic dispersion tolerance of the proposed system are ˜-28.3 dBm and ˜336 ps/nm, respectively. The performance of AACC is delineated to be improved by 7.8 dB in terms of receiver sensitivity compared to 4-PAM in back-to-back scenario. The comparison results also show a clear advantage of AACC in achieving longer fiber transmission distance due to the higher dispersion tolerance in optical access networks.

  8. A Numerical Method to Study Highly Correlated Nanostructures: The Logarithmic Discretization Embedded Cluster Approximation

    Science.gov (United States)

    Anda, E.; Chiappe, G.; Busser, C.; Davidovich, M.; Martins, G.; H-Meisner, F.; Dagotto, E.

    2008-03-01

    A numerical algorithm to study transport properties of highly correlated local structures is proposed. The method, dubbed the Logarithmic Discretization Embedded Cluster Approximation (LDECA), consists of diagonalizing a finite cluster containing the many-body terms of the Hamiltonian and embedding it into the rest of the system, combined with Wilson's ideas of a logarithmic discretization of the representation of the Hamiltonian. LDECA's rapid convergence eliminates finite-size effects commonly present in the embedding cluster approximation (ECA) method. The physics associated with both one embedded dot and a string of two dots side-coupled to leads is discussed. In the former case, our results accurately agree with Bethe ansatz (BA) data, while in the latter, the results are framed in the conceptual background of a two-stage Kondo problem. A diagrammatic expansion provides the theoretical foundation for the method. It is argued that LDECA allows for the study of complex problems that are beyond the reach of currently available numerical methods.

  9. 32-channel time-correlated-single-photon-counting system for high-throughput lifetime imaging

    Science.gov (United States)

    Peronio, P.; Labanca, I.; Acconcia, G.; Ruggeri, A.; Lavdas, A. A.; Hicks, A. A.; Pramstaller, P. P.; Ghioni, M.; Rech, I.

    2017-08-01

    Time-Correlated Single Photon Counting (TCSPC) is a very efficient technique for measuring weak and fast optical signals, but it is mainly limited by the relatively "long" measurement time. Multichannel systems have been developed in recent years aiming to overcome this limitation by managing several detectors or TCSPC devices in parallel. Nevertheless, if we look at state-of-the-art systems, there is still a strong trade-off between the parallelism level and performance: the higher the number of channels, the poorer the performance. In 2013, we presented a complete and compact 32 × 1 TCSPC system, composed of an array of 32 single-photon avalanche diodes connected to 32 time-to-amplitude converters, which showed that it was possible to overcome the existing trade-off. In this paper, we present an evolution of the previous work that is conceived for high-throughput fluorescence lifetime imaging microscopy. This application can be addressed by the new system thanks to a centralized logic, fast data management and an interface to a microscope. The new conceived hardware structure is presented, as well as the firmware developed to manage the operation of the module. Finally, preliminary results, obtained from the practical application of the technology, are shown to validate the developed system.

  10. Down-regulation of p73 correlates with high histological grade in Japanese with breast carcinomas

    Institute of Scientific and Technical Information of China (English)

    DU Cai-wen; Izo Kimijima; Toru Otake; Rikiya Abe; Seiichi Takenoshita; ZHANG Guo-jun

    2011-01-01

    Background p73, a homologue of p53, has been located at chromosome 1 p36-33, a region of frequently observed loss of heterozygosity in breast cancers. The objective of the present study was to investigate the function of p73 in Japanese with breast cancers. Methods Sixty Japanese patients with breast cancer were assessed by polymerase chain reaction single strand confirmation polymorphism analysis and direct sequencing to detect the p73 allele. p73 mRNA levels were also determined in 40 out of 60 patients by reverse-transcriptional polymerase chain reaction. Results We analyzed the entire open reading frame of the p73 gene by polymerase chain reaction single strand confirmation polymorphism and sequencing, and failed to identify any mutations of p73 in the encoding regions detected.Loss of heterozygosity of p73 was infrequent and only found in 9% of breast carcinomas. We revealed a few polymorphisms with a frequency of 13%-29%, which had been reported previously. Down-regulation of p73 mRNA expression was observed in tumor tissues in comparison to the normal breast tissues. A significant inverse correlation was found between p73 transcripts and high histological grade, suggesting that down-regulated p73 expression could be related to poor prognosis in those patients. Conclusion Our results suggest that p73 may serve as a tumor suppressor gene and its expression plays a role in tumorigenesis in Japanese patients with breast cancer.

  11. Eelgrass Leaf Surface Microbiomes Are Locally Variable and Highly Correlated with Epibiotic Eukaryotes

    Directory of Open Access Journals (Sweden)

    Mia M. Bengtsson

    2017-07-01

    Full Text Available Eelgrass (Zostera marina is a marine foundation species essential for coastal ecosystem services around the northern hemisphere. Like all macroscopic organisms, it possesses a microbiome (here defined as an associated prokaryotic community which may play critical roles in modulating the interaction of eelgrass with its environment. For example, its leaf surface microbiome could inhibit or attract eukaryotic epibionts which may overgrow the eelgrass leading to reduced primary productivity and subsequent eelgrass meadow decline. We used amplicon sequencing of the 16S and 18S rRNA genes of prokaryotes and eukaryotes to assess the leaf surface microbiome (prokaryotes as well as eukaryotic epibionts in- and outside lagoons on the German Baltic Sea coast. Prokaryote microbiomes varied substantially both between sites inside lagoons and between open coastal and lagoon sites. Water depth, leaf area and biofilm chlorophyll a concentration explained a large amount of variation in both prokaryotic and eukaryotic community composition. The prokaryotic microbiome and eukaryotic epibiont communities were highly correlated, and network analysis revealed disproportionate co-occurrence between a limited number of eukaryotic taxa and several bacterial taxa. This suggests that eelgrass leaf surfaces are home to a mosaic of microbiomes of several epibiotic eukaryotes, in addition to the microbiome of the eelgrass itself. Our findings thereby underline that eukaryotic diversity should be taken into account in order to explain prokaryotic microbiome assembly and dynamics in aquatic environments.

  12. Role of cardiotocography in high risk pregnancy and its correlation with increase cesarean section rate

    Directory of Open Access Journals (Sweden)

    Manisha Gupta

    2016-12-01

    Full Text Available Background: FHR monitoring plays the most important role in management of labouring patient when incidence of fetal hypoxia and progressive asphyxia increases. Now a day’s cardiotocography (CTG become a popular method for monitoring of fetal wellbeing and it is assisting the obstetrician in making the decision on the mode of delivery to improve perinatal outcome. The aim of the study was to assess the effect of cardiotocography on perinatal outcome and its correlation with caesarean section rate. Methods: In this prospective observational study 201 gravid women with high risk pregnancy in first stage of labour were taken. Result was assessed in the form of Apgar score at five minute, NICU admission, perinatal mortality and mode of delivery. Statistical analysis is done by using Chi square test and p<0.05 is considered as statistically significant. Results: Perinatal morbidity in the form of NICU admission is higher in nonreactive group as compare to reactive group (75.7% v/s 22.8%. Cesarean section rate for fetal distress were higher in nonreactive group (87.8% in comparison to reactive group (20.5%. So this study suggest that there is significant difference in mode of delivery with increasing chances of caesarean section in cases belong to non-reactive traces (p<0.001. Conclusions: Admission test is non-invasive and the best screening test to evaluate the fetal health and to predict the perinatal outcome but it also associated with increase caesarean section rate.

  13. Clinical applications of high-speed blood flow measurements with diffuse correlation spectroscopy

    Science.gov (United States)

    Parthasarathy, Ashwin B.; Baker, Wesley B.; Gannon, Kimberly; Mullen, Michael T.; Detre, John A.; Yodh, Arjun G.

    2017-02-01

    Diffuse Correlation Spectroscopy (DCS) is an increasingly popular non-invasive optical technique to clinically measure deep tissue blood flow, albeit at slow measurement rates of 0.5-1 Hz. We recently reported the development of a new `fast' DCS instrument that continuously measures blood flow at 50-100 Hz (simultaneously from 8 channels), using conventional DCS sources/detectors, and optimized software computations. A particularly interesting result was our ability to optically record pulsatile micro-vascular blood flow waveforms, and therein readily identify high frequency features such as the dicrotic notch. Here, we showcase the utility and potential of high-speed measurements of blood flow (and arterial blood pressure) in a few clinical applications. First, we employ the fast-DCS instrumentation to measure cerebral autoregulation (CVAR) dynamics. Cerebral autoregulation refers to the mechanism by which cerebral blood flow (CBF) is maintained during fluctuations in blood pressure; CVAR is impaired in the injured brain. We derive an index of autoregulation by measuring the rates of decrease (and recovery) of blood flow and blood pressure following a sudden, induced change in systemic blood pressure (e.g., bilateral thigh cuff deflation). Our pilot experiments in healthy volunteers show that DCS measured rates of micro-vascular regulation are comparable to conventional large vessel regulatory metrics (e.g., measured with transcranial Doppler ultrasound). Second, we utilized pulsatile blood flow oscillations in cerebral arteries to estimate the critical closing pressure (CrCP), i.e., the arterial blood pressure at which CBF approaches zero. Pilot experiments in healthy subjects show good agreement between CrCP measured with DCS and transcranial Doppler ultrasound.

  14. Correlations of health behaviors and factors with high sensitivity C-reactive protein in diabetic population

    Directory of Open Access Journals (Sweden)

    Jin-hong HOU

    2013-11-01

    Full Text Available Objective To explore the correlations of ideal cardiovascular health behaviors and factors with the level of high sensitivity C-reactive protein (hsCRP in diabetic population. Methods A cross-sectional method was used in present study. Seven thousand eight hundred and sixty-nine workers with diabetes were recruited who participated in the 2006-2007 Kailuan health examination without history of cerebral and myocardial infarction and without data incompleted. All the information was obtained from the unified questionnaire and measurement of blood biochemistry. Multivariate logistic regression analysis was used to analyze the effects of ideal cardiovascular health behaviors and factors on the level of hsCRP. Results The hsCRP concentrations decreased with the increasing numbers of ideal cardiovascular health behaviors and factors, the medians of hsCRP concentrations were 1.16mg/L, 1.11mg/L, 0.90mg/L and 0.76mg/L in 0-1, 2, 3 and 4-6 ideal cardiovascular health groups, respectively (P<0.01. Multivariate logistic regression analysis showed that, after adjustment by age, gender, triglyceride, low density lipoprotein cholesterol (LDL-C and high density lipoprotein cholesterol (HDL-C, the risk of hsCRP level exceeding 3mg/L in the subjects having 3 and 4-6 ideal cardiovascular health behaviors and factors was 0.60 times (95%CI 0.50-0.72 and 0.45 times (95%CI 0.34-0.61, respectively, than those having 0-1 ideal cardiovascular health behaviors and factors. Conclusion The hsCRP concentrations decreased with increasing numbers of ideal cardiovascular health behaviors and factors; the risk of hsCRP exceeding 3mg/L can be reduced by ideal cardiovascular health behaviors and factors. DOI: 10.11855/j.issn.0577-7402.2013.10.013

  15. High precision cross-correlated imaging in few-mode fibers

    Science.gov (United States)

    Muliar, Olena; Usuga Castaneda, Mario A.; Kristensen, Torben; Tanggaard Alkeskjold, Thomas; Rottwitt, Karsten; Lægsgaard, Jesper

    2017-01-01

    The trend of increasing data traffic in conventional communication systems demands utilizing new methods for data transmission, which in combination with traditional techniques, enable overcoming the predicted capacity limit. Mode division multiplexing (MDM), where higher-order modes (HOMs) in a few-mode fiber (FMF) are used as multiple spatial communication channels, comes in this context as a viable approach to enable the optimization of high-capacity links. From this perspective, it becomes highly necessary to possess a diagnostic tool for the precise modal characterization of FMFs. Among existing approaches for modal content analysis, several methods as S2, C2 in time and frequency domain are available. In this contribution we will present an improved time-domain cross-correlated (C2) imaging technique for the experimental evaluation of modal properties in HOM fibers over a broad range of wavelengths. Our modified setup makes it possible to adjust the time resolution of the system according to the needs of the required fiber measurement. We show that by tuning the spectral shape of the source (SuperK EXTREME filtered by SuperK Select), we enhance the time resolution of the system, which allows us to distinguishing differential time delays between HOMs in the picosecond timescale. Broad wavelength scanning in combination with spectral shaping, allows us to estimate the modal behavior of FMF without prior knowledge of the fiber parameters. We performed our demonstration at wavelengths from 850nm to 1100nm which can be easily extended to other wavelengths of interest just by replacing components with the appropriate coating. The method presented here aims to serve as flexible diagnostic tool that can be implemented in MDM systems for judicious evaluation of modal dispersion in FMFs.

  16. Correlates of tackling ability in high-performance rugby league players.

    Science.gov (United States)

    Gabbett, Tim J; Jenkins, David G; Abernethy, Bruce

    2011-01-01

    This study investigated the tackling ability of high-performance rugby league players and determined the relationship between physiological and anthropometric qualities and tackling ability in these athletes. Twenty professional (National Rugby League) and 17 semiprofessional (Queensland Cup) rugby league players underwent a standardized 1-on-1 tackling drill in a 10-m grid. Video footage was taken from the rear, side, and front of the defending player. Tackling proficiency was assessed using standardized technical criteria. In addition, all players underwent measurements of standard anthropometry (height, body mass, and sum of 7 skinfolds), acceleration (10-m sprint), change of direction speed (505 test), and lower body muscular power (vertical jump). Professional players had significantly greater (p ≤ 0.05) tackling proficiency than semiprofessional players (87.5 ± 2.0 vs. 75.0 ± 2.3%). Professional players were significantly (p ≤ 0.05) older, more experienced, leaner, and had greater acceleration than semiprofessional players. The strongest individual correlates of tackling ability were age (r = 0.41, p ≤ 0.05), playing experience (r = 0.70, p ≤ 0.01), skinfold thickness (r = -0.59, p ≤ 0.01), acceleration (r = 0.41, p ≤ 0.05), and lower body muscular power (r = 0.38, p ≤ 0.05). When hierarchical multiple regression analysis was performed to determine which of the variables predicted tackling ability, playing experience and lower body muscular power were the only variables that contributed significantly (r2 = 0.60, p ≤ 0.01) to the predictive model. From a practical perspective, strength and conditioning coaches should emphasize the development of acceleration, lower body muscular power, and lean muscle mass to improve tackling ability in high-performance rugby league players.

  17. Correlation between Grades 4th, 8th, and 11th English Language Arts Scores and High School Graduation

    Science.gov (United States)

    Parese, Errin C.

    2014-01-01

    The focus of this research was on students' low graduation rate in a New York State high school, investigating a possible correlation between students' longitudinal English Language Arts (ELA) exams and their graduation status. In the 2010-11 school year, 25% of the students at the high school of study failed to graduate, a rate which was 5% lower…

  18. Correlation of Managers' Value Systems and Students' Moral Development in High Schools and Pre-University Centers

    Science.gov (United States)

    Alavi, Hamid Reza; Rahimipoor, Tahereh

    2010-01-01

    The goal of this research was to understand the managers' value system, the students' moral development, and their relationship in the high schools and pre-universities of District One in Kerman City. The research method used was descriptive-correlational. The statistical population was composed of high school and pre-university managers and…

  19. Factors that influence disease-specific quality of life or health status in patients with COPD : a systematic review and meta-analysis of Pearson correlations

    NARCIS (Netherlands)

    Tsiligianni, Ioanna; Kocks, Janwillem; Tzanakis, Nikolaos; Siafakas, Nikolaos; van der Molen, Thys

    Background: A major goal in the management of chronic obstructive pulmonary disease (COPD) is to ensure that the burden of the disease for patients with COPD is limited and that patients will have the best possible quality of life. Aims: To explore all the possible factors that could influence

  20. Feasibility of in situ, high-resolution correlation of tracer uptake with histopathology by quantitative autoradiography of biopsy specimens obtained under 18F-FDG PET/CT guidance.

    Science.gov (United States)

    Fanchon, Louise M; Dogan, Snjezana; Moreira, Andre L; Carlin, Sean A; Schmidtlein, C Ross; Yorke, Ellen; Apte, Aditya P; Burger, Irene A; Durack, Jeremy C; Erinjeri, Joseph P; Maybody, Majid; Schöder, Heiko; Siegelbaum, Robert H; Sofocleous, Constantinos T; Deasy, Joseph O; Solomon, Stephen B; Humm, John L; Kirov, Assen S

    2015-04-01

    Core biopsies obtained using PET/CT guidance contain bound radiotracer and therefore provide information about tracer uptake in situ. Our goal was to develop a method for quantitative autoradiography of biopsy specimens (QABS), to use this method to correlate (18)F-FDG tracer uptake in situ with histopathology findings, and to briefly discuss its potential application. Twenty-seven patients referred for a PET/CT-guided biopsy of (18)F-FDG-avid primary or metastatic lesions in different locations consented to participate in this institutional review board-approved study, which complied with the Health Insurance Portability and Accountability Act. Autoradiography of biopsy specimens obtained using 5 types of needles was performed immediately after extraction. The response of autoradiography imaging plates was calibrated using dummy specimens with known activity obtained using 2 core-biopsy needle sizes. The calibration curves were used to quantify the activity along biopsy specimens obtained with these 2 needles and to calculate the standardized uptake value, SUVARG. Autoradiography images were correlated with histopathologic findings and fused with PET/CT images demonstrating the position of the biopsy needle within the lesion. Logistic regression analysis was performed to search for an SUVARG threshold distinguishing benign from malignant tissue in liver biopsy specimens. Pearson correlation between SUVARG of the whole biopsy specimen and average SUVPET over the voxels intersected by the needle in the fused PET/CT image was calculated. Activity concentrations were obtained using autoradiography for 20 specimens extracted with 18- and 20-gauge needles. The probability of finding malignancy in a specimen is greater than 50% (95% confidence) if SUVARG is greater than 7.3. For core specimens with preserved shape and orientation and in the absence of motion, one can achieve autoradiography, CT, and PET image registration with spatial accuracy better than 2 mm. The

  1. Lung parenchyma changes in ankylosing spondylitis: demonstration with high resolution CT and correlation with disease duration

    Energy Technology Data Exchange (ETDEWEB)

    Senocak, Oezlem E-mail: emine.senocak@deu.edu.tr; Manisali, Metin; Oezaksoy, Dinc; Sevinc, Can; Akalin, Elif

    2003-02-01

    Objective: To analyze the spectrum of the lung parenchyma changes in ankylosing spondylitis (AS) with high resolution computed tomography (HRCT) and correlate the findings with disease duration. Material and methods: Twenty patients (18 male, 2 female) with the diagnosis of AS according to New York criteria were included in the study. None of the patients had history of tuberculosis, prolonged inorganic dust exposure and hospitalization for pneumonia. Seven of the patients were smokers, three patients were ex-smokers, and 10 patients were nonsmokers. The patients were assigned to three groups depending on disease duration. Group 1: patients with disease duration {<=}5 years (n: four patients), group 2: patients with disease duration {>=}6 years but {<=}10 years (n: four patients), group 3: patients with disease duration {>=}11 years (n: 12 patients). HRCT and pulmonary function tests (PFT) were performed in all patients. Results: HRCT demonstrated pathology in 17 patients (85%). Two patients in group 1, 4 patients in group 2 and 11 patients in group 3 had pulmonary parenchyma changes. Emphysema (9/20), septal thickening (9/20) and pleural thickening (9/20) were the most common changes followed by nodule (8/20) and subpleural band formation (7/20). Three patients had apical fibrosis (AF). Septal and pleural thickening (both 4/10) were the most common changes when only nonsmokers were considered. Among nine patients with emphysema three were nonsmokers. Conclusion: There is a wide spectrum in pulmonary parenchyma changes in AS. These changes begin in early stages of the disease and increase with disease duration. Although smoking complicates the spectrum of changes in pulmonary parenchyma, they are predominately in the form of interstitial inflammation.

  2. Correlation of Bandgap Reduction with Inversion Response in (Si)GeSn/High-k/Metal Stacks.

    Science.gov (United States)

    Schulte-Braucks, C; Narimani, K; Glass, S; von den Driesch, N; Hartmann, J M; Ikonic, Z; Afanas'ev, V V; Zhao, Q T; Mantl, S; Buca, D

    2017-03-15

    The bandgap tunability of (Si)GeSn group IV semiconductors opens a new era in Si-technology. Depending on the Si/Sn contents, direct and indirect bandgaps in the range of 0.4-0.8 eV can be obtained, offering a broad spectrum of both photonic and low power electronic applications. In this work, we systematically studied capacitance-voltage characteristics of high-k/metal gate stacks formed on GeSn and SiGeSn alloys with Sn-contents ranging from 0 to 14 at. % and Si-contents from 0 to 10 at. % particularly focusing on the minority carrier inversion response. A clear correlation between the Sn-induced shrinkage of the bandgap energy and enhanced minority carrier response was confirmed using temperature and frequency dependent capacitance voltage-measurements, in good agreement with k.p theory predictions and photoluminescence measurements of the analyzed epilayers as reported earlier. The enhanced minority generation rate for higher Sn-contents can be firmly linked to the bandgap reduction in the GeSn epilayer without significant influence of substrate/interface effects. It thus offers a unique possibility to analyze intrinsic defects in (Si)GeSn epilayers. The extracted dominant defect level for minority carrier inversion lies approximately 0.4 eV above the valence band edge in the studied Sn-content range (0-12.5 at. %). This finding is of critical importance since it shows that the presence of Sn by itself does not impair the minority carrier lifetime. Therefore, the continuous improvement of (Si)GeSn material quality should yield longer nonradiative recombination times which are required for the fabrication of efficient light detectors and to obtain room temperature lasing action.

  3. High expression of Sox10 correlates with tumor aggressiveness and poor prognosis in human nasopharyngeal carcinoma

    Directory of Open Access Journals (Sweden)

    Zhao Y

    2016-03-01

    Full Text Available Yu Zhao,1,* Zhi-gang Liu,1,* Jiao Tang,1 Ren-fang Zou,1 Xiao-yan Chen,2 Guan-min Jiang,3 Yan-fang Qiu,1 Hui Wang11Key Laboratory of Translational Radiation Oncology, Department of Radiation Oncology, 2Department of Pathology, 3Department of Clinical Laboratory, Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, People’s Republic of China*These authors contributed equally to this workPurpose: The aim of the study was to detect the expression of Sox10 in human nasopharyngeal carcinoma (NPC and investigate the relationship between its expression and the clinicopathological characteristics of NPC patients.Patients and methods: Tumor specimens (n=105 were retrospectively collected from patients with NPC diagnosed between 2004 and 2005 who presented at Hunan Cancer Hospital. Immunohistochemistry analyses were performed to characterize the expression of Sox10 in NPC. Kaplan–Meier survival and Cox regression analyses were employed to evaluate the prognosis of 105 NPC patients.Results: The results showed that Sox10 was markedly overexpressed in human NPC tissues. Analysis of clinicopathological parameters showed that high Sox10 expression was significantly correlated with the clinical stage (P=0.032, T classification (P=0.034, and lymph node metastasis (P=0.03. Cox regression analyses further showed that Sox10 expression was an independent prognostic factor for overall survival (P=0.005. This is the first time Sox10 has shown its importance in predicting NPC progressiveness and survival outcomes.Conclusion: Sox10 serves as a potential biomarker for NPC patients. It may hopefully become a novel therapeutic target for NPC patients.Keywords: Sox10, NPC, prognosis

  4. Robustness analysis of bimodal networks in the whole range of degree correlation

    CERN Document Server

    Mizutaka, Shogo

    2016-01-01

    We present exact analysis of the physical properties of bimodal networks specified by the two peak degree distribution fully incorporating the degree-degree correlation between node connection. The structure of the correlated bimodal network is uniquely determined by the Pearson coefficient of the degree correlation, keeping its degree distribution fixed. The percolation threshold and the giant component fraction of the correlated bimodal network are analytically calculated in the whole range of the Pearson coefficient from $-1$ to $1$ against two major types of node removal, which are the random failure and the degree-based targeted attack. The Pearson coefficient for next-nearest-neighbor pairs is also calculated, which always takes a positive value even when the correlation between nearest-neighbor pairs is negative. From the results, it is confirmed that the percolation threshold is a monotonically decreasing function of the Pearson coefficient for the degrees of nearest-neighbor pairs increasing from $-1...

  5. Relationship between the TCAP and the Pearson Benchmark Assessment in Elementary Students' Reading and Math Performance in a Northeastern Tennessee School District

    Science.gov (United States)

    Dugger-Roberts, Cherith A.

    2014-01-01

    The purpose of this quantitative study was to determine if there was a relationship between the TCAP test and Pearson Benchmark assessment in elementary students' reading and language arts and math performance in a northeastern Tennessee school district. This study involved 3rd, 4th, 5th, and 6th grade students. The study focused on the following…

  6. Test Review: Wechsler, D. (2014),"Wechsler Intelligence Scale for Children, Fifth Edition: Canadian 322 (WISC-V[superscript CDN])." Toronto, Ontario: Pearson Canada Assessment.

    Science.gov (United States)

    Cormier, Damien C.; Kennedy, Kathleen E.; Aquilina, Alexandra M.

    2016-01-01

    The Wechsler Intelligence Scale for Children, Fifth Edition: Canadian (WISC-V[superscript CDN]; Wechsler, 2014) is published by Pearson Canada Assessment. The WISC-V[superscript CDN] is a norm-referenced, individually administered intelligence battery that provides a comprehensive diagnostic profile of the cognitive strengths and weaknesses of…

  7. Abnormal Axon Reflex-Mediated Sweating Correlates with High State of Anxiety in Atopic Dermatitis

    Directory of Open Access Journals (Sweden)

    Akiko Kijima

    2012-01-01

    Conclusions: Although the number of study subjects was little, abnormal AXR sweating in patients with AD was observed. Correlative analysis suggests possible involvement of continuous anxiety and the immune system in such abnormal sudomotor function.

  8. Long-range rapidity correlations in soft interactions at high energies

    Science.gov (United States)

    Gotsman, E.; Levin, E.; Maor, U.

    2013-12-01

    In this paper we take the next step (following the successful description of inclusive hadron production) in describing the structure of the bias events without the aid of Monte Carlo codes. Two new results are presented: (i) a method for calculating the two particle correlation functions in the BFKL pomeron calculus in zero transverse dimension; and (ii) an estimation of the values of these correlations in a model of soft interactions. Comparison with the multiplicity data at the LHC is given.

  9. Electron localizability indicators ELI and ELIA: the case of highly correlated wavefunctions for the argon atom.

    Science.gov (United States)

    Bezugly, Viktor; Wielgus, Pawel; Wagner, Frank R; Kohout, Miroslav; Grin, Yuri

    2008-06-01

    Electron localizability indicators based on the same-spin electron pair density and the opposite-spin electron pair density are studied for correlated wavefunctions of the argon atom. Different basis sets and reference spaces are used for the multireference configuration interaction method following the complete active space calculations aiming at the understanding of the effect of local electron correlation when approaching the exact wavefunction. The populations of the three atomic shells of Ar atom in real space are calculated for each case.

  10. Correlations between D and D-bar mesons in high energy photoproduction

    Energy Technology Data Exchange (ETDEWEB)

    Gottschalk, Erik E.; Link, J.; Reyes, M.; Yager, P.M.; Anjos, J.; Bediaga, I.; Gobel, C.; Magnin, J.; Massafferri, A.; Miranda, J.M. de; Pepe, I.M.; Reis, A.C. dos; Carrillo, S.; Casimiro, E.; Cuautle, E.; Sanchez-Hernandez, A.; Uribe, C.; Vasquez, F.; Agostino, L.; Cinquini, L.; Cumalat, J.P.; O' Reilly, B.; Ramirez, J.E.; Segoni, I.; Butler, J.N.; Cheung, H.W.K.; Chiodini, G.; Gaines, I.; Garbincius, P.H.; Garren, L.A.; Gottschalk, E.E.; Kasper, P.H.; Kreymer, A.E.; Kutschke, R.; Benussi, L.; Bianco, S.; Fabbri, F.L.; Zallo, A.; Cawlfield, C.; Kim, D.Y.; Park, K.S.; Rahimi, A.; Wiss, J.; Gardner, R.; Kryemadhi, A.; Chang, K.H.; Chung, Y.S.; Kang, J.S.; Ko, B.R.; Kwak, J.W.; Lee, K.B.; Cho, K.; Park, H.; Alimonti, G.; Barberis, S.; Cerutti, A.; Boschini, M.; D' Angelo, P.; DiCorato, M.; Dini, P.; Edera, L.; Erba, S.; Giammarchi, M.; Inzani, P.; Leveraro, F.; Malvezzi, S.; Menasce, D.; Mezzadri, M.; Moroni, L.; Pedrini, D.; Pontoglio, C.; Prelz, F.; Rovere, M.; Sala, S.; Davenport, T.F.; Arena, V.; Boca, G.; Bonomi, G.; Gianini, G.; Liguori, G.; Merlo, M.M.; Pantea, D.; Ratti, S.P.; Vitulo, P.; Hernandez, H.; Lopez, A.M.; Mendez, H.; Mendez, L.; Montiel, E.; Olaya, D.; Paris, A.; Quinones, J.; Rivera, C.; Xiong, W.; Zhang, Y.; Wilson, J.R.; Handler, T.; Mitchell, R.; Engh, D.; Hosack, M.; Johns, W.E.; Nehring, M.; Sheldon, P.D.; Stenson, K.; Vaadering, E.W.; Webster, M.; Sheaff, M

    2003-04-01

    Over 7000 events containing a fully reconstructed D D-bar pair have been extracted from data recorded by the FOCUS photoproduction experiment at Fermilab. Preliminary results from a study of correlations between D and D-bar mesons are presented. Correlations are used to study perturbative QCD predictions and investigate non-perturbative effects. We also present a preliminary result on the production of {psi}(3770)

  11. Universality, Correlations, and Rankings in the Brazilian Universities National Admission Examinations

    CERN Document Server

    da Silva, Roberto; Barbosa, Marcia C

    2015-01-01

    The scores obtained by students that have performed the ENEM exam, the Brazilian High School National Examination used to admit students at the Brazilian universities, is analyzed. The average high school's scores are compared between different disciplines through the Pearson correlation coefficient. The results show a very large correlation between the performance in the different subjects. Even thought the students' scores in the ENEM due to the standardization form a Gaussian, we show that the high schools' scores form a bimodal distribution that can not be used to evaluate and compare performance over time. We also show that this high schools distribution reflects the correlation between school performance and economic level of the students. The ENEM's scores are compared with a Brazilian non standardized exam, the entrance exam at the Universidade Federal do Rio Grande do Sul. The comparison of the performance of the same individuals in both tests is compared showing that the two tests not only select di...

  12. DIAGNOSIS AND IDENTIFICATION OF DYNAMIC CORRELATION FACTORS BETWEEN WEST-PACIFIC SUBTROPICAL HIGH AND EAST ASIA MONSOON SYSTEM INDEXES

    Institute of Scientific and Technical Information of China (English)

    DONG Zhao-jun; ZHANG Ren; YU Dan-dan; CHENG Ming; WAN Lei

    2008-01-01

    Based on the daily reanalysis data ofNCEP / NCAR and by using the method of phase space reconstruction, the point conditional probability density of the subtropical high ridge index are determined and then used, together with their power spectra, to seek the correlation between them and individual monsoon-affecting factors and their power spectra. Through diagnosis, six indexes are discovered that have the most important effects on the subtropical high index. The results of the diagnosis indicate that the technique can identify the factors which are dynamically correlated. It can offer the basis in determining and choosing dynamic conceptual factors.

  13. High Preexisting Serological Antibody Levels Correlate with Diversification of the Influenza Vaccine Response

    Science.gov (United States)

    Andrews, Sarah F.; Kaur, Kaval; Pauli, Noel T.; Huang, Min; Huang, Yunping

    2015-01-01

    ABSTRACT Reactivation of memory B cells allows for a rapid and robust immune response upon challenge with the same antigen. Variant influenza virus strains generated through antigenic shift or drift are encountered multiple times over the lifetime of an individual. One might predict, then, that upon vaccination with the trivalent influenza vaccine across multiple years, the antibody response would become more and more dominant toward strains consistently present in the vaccine at the expense of more divergent strains. However, when we analyzed the vaccine-induced plasmablast, memory, and serological responses to the trivalent influenza vaccine between 2006 and 2013, we found that the B cell response was most robust against more divergent strains. Overall, the antibody response was highest when one or more strains contained in the vaccine varied from year to year. This suggests that in the broader immunological context of viral antigen exposure, the B cell response to variant influenza virus strains is not dictated by the composition of the memory B cell precursor pool. The outcome is instead a diversified B cell response. IMPORTANCE Vaccine strategies are being designed to boost broadly reactive B cells present in the memory repertoire to provide universal protection to the influenza virus. It is important to understand how past exposure to influenza virus strains affects the response to subsequent immunizations. The viral epitopes targeted by B cells responding to the vaccine may be a direct reflection of the B cell memory specificities abundant in the preexisting immune repertoire, or other factors may influence the vaccine response. Here, we demonstrate that high preexisting serological antibody levels to a given influenza virus strain correlate with low production of antibody-secreting cells and memory B cells recognizing that strain upon revaccination. In contrast, introduction of antigenically novel strains generates a robust B cell response. Thus, both the

  14. Probing superfluid properties in strongly correlated Fermi gases with high spatial resolution

    Energy Technology Data Exchange (ETDEWEB)

    Weimer, Wolf

    2014-07-01

    In this thesis an apparatus to study ultracold fermionic {sup 6}Li with tunable interaction strength and dimensionality is presented. The apparatus is applied to investigate the speed of sound v{sub s} and the superfluid critical velocity v{sub c} across the transition from Bose-Einstein condensation (BEC) to Bardeen-Cooper-Schrieffer (BCS) superfluidity. The results set benchmarks for theories describing strongly correlated systems. To measure v{sub c}, an obstacle, that is formed by a tightly focused laser beam, is moved through a superfluid sample with a constant velocity along a line of constant density. For velocities larger than v{sub c} heating of the gas is observed. The critical velocity is mapped out for various different interaction strengths covering the BEC-BCS crossover. According to the Landau criterion and Bogolyubov theory, v{sub c} should be closely related to v{sub s} in a Bose-Einstein condensate. The measurement of v{sub s} is conducted by creating a density modulation in the centre of the cloud and tracking the excited modulation. The velocities v{sub s} and v{sub c} are measured in a similar range of interaction strengths and in similar samples to ensure comparability. The apparatus which provides the ultracold samples is a two chamber design with a magneto-optical trap that is loaded via a Zeeman slower. The subsequent cooling steps are all-optical and finally create an ultracold oblate atom cloud inside a flat vacuum cell. This cell provides optimal optical access and is placed between two high numerical aperture microscope objectives. These objectives are used to probe the samples in-situ on length scales which are comparable to the intrinsic length scales of the gases. Similarly, optical dipole potentials are employed to manipulate the clouds on the same small length scales. The oblate samples are sufficiently flat such that there spatial extent along the microscope axes is smaller than the depth of field of the objectives. With an

  15. Estimation of the simple correlation coefficient.

    Science.gov (United States)

    Shieh, Gwowen

    2010-11-01

    This article investigates some unfamiliar properties of the Pearson product-moment correlation coefficient for the estimation of simple correlation coefficient. Although Pearson's r is biased, except for limited situations, and the minimum variance unbiased estimator has been proposed in the literature, researchers routinely employ the sample correlation coefficient in their practical applications, because of its simplicity and popularity. In order to support such practice, this study examines the mean squared errors of r and several prominent formulas. The results reveal specific situations in which the sample correlation coefficient performs better than the unbiased and nearly unbiased estimators, facilitating recommendation of r as an effect size index for the strength of linear association between two variables. In addition, related issues of estimating the squared simple correlation coefficient are also considered.

  16. Manifestation of proton structure in ridge-like correlations in high-energy proton-proton collisions

    CERN Document Server

    Kubiczek, Patryk

    2015-01-01

    Recently, the CMS collaboration reported a long range in rapidity, near-side ('ridge-like') angular correlations in high-energy proton-proton collisions, so called ridge effect. This surprising observation suggests the presence of a collective flow that resembles the one believed to produce a similar correlation hydrodynamically in heavy-ion collisions. If the hydrodynamic description is valid then the effect is triggered by the initial spatial anisotropy of the colliding matter. Estimating this anisotropy within different models of the proton internal structure in comparison with measured angular correlations in high-energy proton-proton collision data could in principle discriminate between different proton models. Inspired by recent theoretical developments, we propose several phenomenological models of the proton structure. Subsequently, we calculate the anisotropy coefficients of the dense matter formed in proton-proton collisions within the formalism of the Monte Carlo Glauber model. We find that some p...

  17. Unveiling linearly and nonlinearly correlated signals between gravitational wave detectors and environmental monitors

    Science.gov (United States)

    Yuzurihara, Hirotaka; Hayama, Kazuhiro; Mano, Shuhei; Verkindt, Didier; Kanda, Nobuyuki

    2016-08-01

    Noise hunting is a critical requirement for realizing design sensitivity of a detector, and consequently, noise origins and its features have been revealed partially. Among the noise sources to be hunted, sources of nonlinearly correlated noise, such up-conversion noise, are hard to find and can limit the sensitivity of gravitational wave searches with advanced detectors. We propose using a correlation analysis method called maximal information coefficient (MIC) to find both nonlinear and linear correlations. We apply MIC to the scattered light noise correlated between the seismic activity and the strain signal, which limited the sensitivity of the Virgo detector during the first science run. The results show that MIC can find nonlinearly correlated noise more efficiently than the Pearson correlation method. When the data is linearly correlated, the efficiency of the Pearson method and MIC is comparable. On the other hand, when the data is known to be nonlinearly correlated, MIC finds the correlation while the Pearson method fails completely.

  18. Correlations and adsorption mechanisms of aromatic compounds on a high heat temperature treated bamboo biochar.

    Science.gov (United States)

    Yang, Kun; Yang, Jingjing; Jiang, Yuan; Wu, Wenhao; Lin, Daohui

    2016-03-01

    Adsorption of aromatic compounds, including polycyclic aromatic hydrocarbons, nitrobenzenes, phenols, and anilines, on a bamboo biochar produced at 700 °C (Ba700) was investigated with the mechanism discussion by isotherm fitting using the Polanyi-theory based Dubinin-Ashtakhov (DA) model. Correlations of adsorption capacity (Q(0)) of organic compounds with their molecular sizes and melting points, as well as correlations of adsorption affinity (E) with their solvatochromic parameters (i.e., π* and αm), on the biochar, were developed and indicating that adsorption is captured by the pore filling mechanism and derived from the hydrophobic effects of organic compounds and the forming of π-π electron donor-acceptor (EDA) interactions and hydrogen bonding interactions of organic molecules with surface sites of the biochar. The effects of organic molecular sizes and melting points on adsorption capacity are ascribed to the molecular sieving effect and the packing efficiency of the organic molecules in the biochar pores, respectively. These correlations can be used to quantitatively estimate the adsorption of organic compounds on biochars from their commonly physicochemical properties including solvatochromic parameters, melting points and molecular cross-sectional area. The prediction using these correlations is important for assessing the unknown adsorption behaviors of new organic compounds and also helpful to guide the surface modification of biochars and make targeted selection in the environmental applications of biochars as adsorbents.

  19. High-resolution imaging by scanning electron microscopy of semithin sections in correlation with light microscopy.

    Science.gov (United States)

    Koga, Daisuke; Kusumi, Satoshi; Shodo, Ryusuke; Dan, Yukari; Ushiki, Tatsuo

    2015-12-01

    In this study, we introduce scanning electron microscopy (SEM) of semithin resin sections. In this technique, semithin sections were adhered on glass slides, stained with both uranyl acetate and lead citrate, and observed with a backscattered electron detector at a low accelerating voltage. As the specimens are stained in the same manner as conventional transmission electron microscopy (TEM), the contrast of SEM images of semithin sections was similar to TEM images of ultrathin sections. Using this technique, wide areas of semithin sections were also observed by SEM, without the obstruction of grids, which was inevitable for traditional TEM. This study also applied semithin section SEM to correlative light and electron microscopy. Correlative immunofluorescence microscopy and immune-SEM were performed in semithin sections of LR white resin-embedded specimens using a FluoroNanogold-labeled secondary antibody. Because LR white resin is hydrophilic and electron stable, this resin is suitable for immunostaining and SEM observation. Using correlative microscopy, the precise localization of the primary antibody was demonstrated by fluorescence microscopy and SEM. This method has great potential for studies examining the precise localization of molecules, including Golgi- and ER-associated proteins, in correlation with LM and SEM.

  20. Correlations of high transverse momentum pi /sup 0/ pairs produced at the CERN ISR

    CERN Document Server

    Kourkoumelis, C; Fabjan, Christian Wolfgang; Fields, T; Filippas-Tassos, A; Fokitis, E; Goldberg, M; Horwitz, N; Iwata, S; Lissauer, D; Mannelli, I; Moneti, G C; Mouzourakis, P; Nappi, A; Palmer, R B; Rahm, David Charles; Rehak, P; Resvanis, L K; Stumer, I; Willis, W J

    1979-01-01

    Correlations of two pi /sup 0/ mesons with transverse momenta up to 10 GeV/c have been measured utilizing apparatus with large azimuthal acceptance. The data are analysed in the context of constituent scattering models, and also compared with a simple 'background' hypothesis. (11 refs).

  1. ICE-based Custom Full-Mesh Network for the CHIME High Bandwidth Radio Astronomy Correlator

    CERN Document Server

    Bandura, Kevin; Dobbs, Matt; Gilbert, Adam; Ittah, David; Parra, Juan Mena; Smecher, Graeme

    2016-01-01

    New generation radio interferometers encode signals from thousands of antenna feeds across large bandwidth. Channelizing and correlating this data requires networking capabilities that can handle unprecedented data rates with reasonable cost. The Canadian Hydrogen Intensity Mapping Experiment (CHIME) correlator processes 8-bits from N=2048 digitizer inputs across 400~MHz of bandwidth. Measured in $N^2~\\times $ bandwidth, it is the largest radio correlator that has been built. Its digital back-end must exchange and reorganize the 6.6~terabit/s produced by its 128 digitizing and channelizing nodes, and feed it to the 256-node spatial correlator in a way that each node obtains data from all digitizer inputs but across a small fraction of the bandwidth (i.e. `corner-turn'). In order to maximize performance and reliability of the corner-turn system while minimizing cost, a custom networking solution has been implemented. The system makes use of Field Programmable Gate Array (FPGA) transceivers to implement direct,...

  2. Mass transfer in wetted-wall columns: correlations at high Reynolds numbers

    DEFF Research Database (Denmark)

    Nielsen, Christian H.E.; Kiil, Søren; Thomsen, Henrik W.;

    1998-01-01

    The rate of gas-and liquid-phase mass transport in a pilot-scale wetted-wall column with an inner diameter of 3.26 cm and a length of 5 m was investigated. Empirical correlations for the physical liquid-phase mass transfer coefficient (k(L)(O)) and the gas-phase mass transfer coefficient (k...

  3. Correlates to Human Papillomavirus Vaccination Status and Willingness to Vaccinate in Low-Income Philadelphia High School Students

    Science.gov (United States)

    Bass, Sarah B.; Leader, Amy; Shwarz, Michelle; Greener, Judith; Patterson, Freda

    2015-01-01

    Background: Little is known about the correlates of human papillomavirus (HPV) vaccination or willingness to be vaccinated in urban, minority adolescents. Methods: Using responses to the 2013 Youth Risk Behavior Survey in Philadelphia, a random sample of high schools provided weighted data representing 20,941 9th to 12th graders. Stratified by…

  4. Final Technical Report, Grant DE-FG02-91ER45443: Heavy fermions and other highly correlated electron systems

    Energy Technology Data Exchange (ETDEWEB)

    Schlottmann, P.

    1998-10-12

    Properties of highly correlated electrons, such as heavy fermion compounds, metal-insulator transitions, one-dimensional conductors and systems of restricted dimensionality are studied theoretically. The main focus is on Kondo insulators and impurity bands due to Kondo holes, the low-temperature magnetoresistivity of heavy fermion alloys, the n-channel Kondo problem, mesoscopic systems and one-dimensional conductors.

  5. Positive correlation between serum taurine and adiponectin levels in high-fat diet-induced obesity rats.

    Science.gov (United States)

    You, Jeong Soon; Zhao, Xu; Kim, Sung Hoon; Chang, Kyung Ja

    2013-01-01

    The purpose of this study was to investigate the relationship between serum taurine level and serum adiponectin or leptin levels in high-fat diet-induced obesity rats. Five-week-old male Sprague-Dawley rats were randomly divided into three groups for a period of 8 weeks (normal diet, N group; high-fat diet, HF group; high-fat diet + taurine, HFT group). Taurine was supplemented by dissolving in feed water (3% w/v), and the same amount of distilled water was orally administrated to N and HF groups. In serum, adiponectin level was higher in HFT group compared to HF group. The serum taurine level was negatively correlated with serum total cholesterol (TC) level and positively correlated with serum adiponectin level. These results suggest that dietary taurine supplementation has beneficial effects on total cholesterol and adiponectin levels in high-fat diet-induced obesity rats.

  6. Schizophrenia - Insight, Depression: A Correlation Study

    Directory of Open Access Journals (Sweden)

    Prasanth Ampalam

    2012-01-01

    Full Text Available Background: Schizophrenia is one of the severe forms of mental illness which demands enormous personal and economical costs. Recent years have attracted considerable interest in the dual problem of depression in schizophrenia and its relation to insight. Most clinicians believe that poor insight in patients with schizophrenia, though problematic for treatment adherence, may be protective with respect to suicide. The assumption is that patients who do not believe that they are ill are less likely to be suicidal. Alternatively, those patients with schizophrenia who recognize and acknowledge the illness will be more of a suicidal nature. Aim of the Study: The aim of the study is to find out the correlation between insight and depression in schizophrenic population. Materials and Methods: This study is a cross-sectional, single-centred, correlation study done in a total of 60 subjects. Inclusion Criteria - Subjects between 20-60 years, who were diagnosed to have schizophrenia as per International clasification of diseases-10 and who have given written consent to participate in the study. Exclusion Criteria - Subjects who have other diagnosis such as mood disorder, schizoaffective disorder, mental retardation, epilepsy or detectable organic disease and co morbid substance abuse are excluded from the study. Schizophrenics who have acute exacerbation are also excluded. Instruments - For insight assessment, schedule for assessment of insight, a three item rating scale, is used. For depressive symptoms assessment a nine item rating scale, Calgary depression rating scale, is administrated. Results: Insight and depression are strongly correlated in schizophrenic population with a Pearson correlation coefficient of 0.758. The correlation between insight and depression is high in subjects with less duration of illness. Conclusion: Better insight was significantly correlated with lower mood. In addition, it suggests that poor insight may protect against

  7. A high-speed readout scheme for fast optical correlation-based pattern recognition

    Science.gov (United States)

    McDonald, Gregor J.; Lewis, Meirion F.; Wilson, Rebecca

    2004-12-01

    We describe recent developments to a novel form of hybrid electronic/photonic correlator, which exploits component innovations in both electronics and photonics to provide fast, compact and rugged target recognition, applicable to a wide range of security applications. The system benefits from a low power, low volume, optical processing core which has the potential to realise man portable pattern recognition for a wide range of security based imagery and target databases. In the seminal Vander Lugt correlator the input image is Fourier transformed optically and multiplied optically with the conjugate Fourier transform of a reference pattern; the required correlation function is completed by taking the inverse Fourier transform of the product optically. The correlator described here is similar in principle, but performs the initial Fourier transforms and multiplication electronically, with only the final most computationally demanding output Fourier transform being performed optically. In this scheme the Fourier transforms of both the input scene and reference pattern are reduced to a binary phase-only format, where the multiplication process simplifies to a simple Boolean logic XOR function. The output of this XOR gate is displayed on a state-of-the-art Fast Bit Plane Spatial Light Modulator (FBPSLM). A novel readout scheme has been developed which overcomes the previous system output bottleneck and for the first time allows correlation frame readout rates capable of matching the inherently fast nature of the SLM. Readout rates of up to ~1 MHz are now possible, exceeding current SLM capabilities and meeting potential medium term SLM developments promised by SLMs based on novel materials and architectures.

  8. Correlation between the TeV and X-ray emission in high--energy peaked BL Lac objects

    CERN Document Server

    Katarzynski, K; Tavecchio, F; Maraschi, L; Fossati, G; Mastichiadis, A

    2004-01-01

    We discuss the correlation between the evolution of the TeV emission and X-ray radiation observed in high-energy peaked BL Lac objects. We describe such a correlation by a simple power law. In the first part of this work we present correlations obtained for the activity of Mrk~501 observed in 1997 April and for the activity of Mrk~421 observed in 2000 February. We also discuss results of similar correlation obtained for this source by other authors. They report an almost quadratic correlations observed between the evolution of the TeV and X-ray emission. In the second part of this paper we present a phenomenological model which describes the evolution of the synchrotron and inverse Compton emission of a simple spherical homogeneous source. Neglecting the radiative cooling of the particles we derive analytical expressions that describe the evolution. Then we use a numerical code to investigate the impact of radiative cooling on the evolution. The quadratic correlation observed during the decay phase of the fla...

  9. A Survey of the Correlation between Language Anxiety and Senior High School Student’s Oral English Performance

    Institute of Scientific and Technical Information of China (English)

    戴安; 甘田

    2014-01-01

    Language anxiety is a kind of apprehension occurs when student need to perform oral English.Many researchers agree that language anxiety is an important factor in English learning.This thesis is going to test 80 students from Bordertown high school,Hunan Province,to uncover the English learning situation of senior high school students,to survey the correlation between language anxiety and oral English performance,and to give inspiration for senior middle school English teaching.

  10. Quantification of optic disc edema during exposure to high altitude shows no correlation to acute mountain sickness.

    Directory of Open Access Journals (Sweden)

    Gabriel Willmann

    Full Text Available BACKGROUND: The study aimed to quantify changes of the optic nerve head (ONH during exposure to high altitude and to assess a correlation with acute mountain sickness (AMS. This work is related to the Tuebingen High Altitude Ophthalmology (THAO study. METHODOLOGY/PRINCIPAL FINDINGS: A confocal scanning laser ophthalmoscope (cSLO, Heidelberg Retina Tomograph, HRT3® was used to quantify changes at the ONH in 18 healthy participants before, during and after rapid ascent to high altitude (4559 m. Slitlamp biomicroscopy was used for clinical optic disc evaluation; AMS was assessed with Lake Louise (LL and AMS-cerebral (AMS-c scores; oxygen saturation (SpO₂ and heart rate (HR were monitored. These parameters were used to correlate with changes at the ONH. After the first night spent at high altitude, incidence of AMS was 55% and presence of clinical optic disc edema (ODE 79%. Key stereometric parameters of the HRT3® used to describe ODE (mean retinal nerve fiber layer [RNFL] thickness, RNFL cross sectional area, optic disc rim volume and maximum contour elevation changed significantly at high altitude compared to baseline (p<0.05 and were consistent with clinically described ODE. All changes were reversible in all participants after descent. There was no significant correlation between parameters of ODE and AMS, SpO₂ or HR. CONCLUSIONS/SIGNIFICANCE: Exposure to high altitude leads to reversible ODE in the majority of healthy subjects. However, these changes did not correlate with AMS or basic physiologic parameters such as SpO₂ and HR. For the first time, a quantitative approach has been used to assess these changes during acute, non-acclimatized high altitude exposure. In conclusion, ODE presents a reaction of the body to high altitude exposure unrelated to AMS.

  11. Quantification of Optic Disc Edema during Exposure to High Altitude Shows No Correlation to Acute Mountain Sickness

    Science.gov (United States)

    Willmann, Gabriel; Fischer, M. Dominik; Schatz, Andreas; Schommer, Kai; Messias, Andre; Zrenner, Eberhart; Bartz-Schmidt, Karl U.; Gekeler, Florian

    2011-01-01

    Background The study aimed to quantify changes of the optic nerve head (ONH) during exposure to high altitude and to assess a correlation with acute mountain sickness (AMS). This work is related to the Tuebingen High Altitude Ophthalmology (THAO) study. Methodology/Principal Findings A confocal scanning laser ophthalmoscope (cSLO, Heidelberg Retina Tomograph, HRT3®) was used to quantify changes at the ONH in 18 healthy participants before, during and after rapid ascent to high altitude (4559 m). Slitlamp biomicroscopy was used for clinical optic disc evaluation; AMS was assessed with Lake Louise (LL) and AMS-cerebral (AMS-c) scores; oxygen saturation (SpO2) and heart rate (HR) were monitored. These parameters were used to correlate with changes at the ONH. After the first night spent at high altitude, incidence of AMS was 55% and presence of clinical optic disc edema (ODE) 79%. Key stereometric parameters of the HRT3® used to describe ODE (mean retinal nerve fiber layer [RNFL] thickness, RNFL cross sectional area, optic disc rim volume and maximum contour elevation) changed significantly at high altitude compared to baseline (p<0.05) and were consistent with clinically described ODE. All changes were reversible in all participants after descent. There was no significant correlation between parameters of ODE and AMS, SpO2 or HR. Conclusions/Significance Exposure to high altitude leads to reversible ODE in the majority of healthy subjects. However, these changes did not correlate with AMS or basic physiologic parameters such as SpO2 and HR. For the first time, a quantitative approach has been used to assess these changes during acute, non-acclimatized high altitude exposure. In conclusion, ODE presents a reaction of the body to high altitude exposure unrelated to AMS. PMID:22069483

  12. Changes in gut microbiota in rats fed a high fat diet correlate with obesity-associated metabolic parameters.

    Science.gov (United States)

    Lecomte, Virginie; Kaakoush, Nadeem O; Maloney, Christopher A; Raipuria, Mukesh; Huinao, Karina D; Mitchell, Hazel M; Morris, Margaret J

    2015-01-01

    The gut microbiota is emerging as a new factor in the development of obesity. Many studies have described changes in microbiota composition in response to obesity and high fat diet (HFD) at the phylum level. In this study we used 16s RNA high throughput sequencing on faecal samples from rats chronically fed HFD or control chow (n = 10 per group, 16 weeks) to investigate changes in gut microbiota composition at the species level. 53.17% dissimilarity between groups was observed at the species level. Lactobacillus intestinalis dominated the microbiota in rats under the chow diet. However this species was considerably less abundant in rats fed HFD (Pobese phenotype, we correlated their abundance with metabolic parameters associated with obesity. Of the taxa contributing the most to dissimilarity between groups, 10 presented significant correlations with at least one of the tested parameters, three of them correlated positively with all metabolic parameters: Phascolarctobacterium, Proteus mirabilis and Veillonellaceae, all propionate/acetate producers. Lactobacillus intestinalis was the only species whose abundance was negatively correlated with change in body weight and fat mass. This species decreased drastically in response to HFD, favouring propionate/acetate producing bacterial species whose abundance was strongly correlated with adiposity and deterioration of metabolic factors. Our observations suggest that these species may play a key role in the development of obesity in response to a HFD.

  13. Mineralogy of the clay fraction of alfisols in two slope curvatures: IV - spatial correlation with physical properties

    Directory of Open Access Journals (Sweden)

    Livia Arantes Camargo

    2013-04-01

    Full Text Available Although the influence of clay mineralogy on soil physical properties has been widely studied, spatial relationships between these features in Alfisols have rarely been examined. The purpose of this work was to relate the clay minerals and physical properties of an Alfisol of sandstone origin in two slope curvatures. The crystallographic properties such as mean crystallite size (MCS and width at half height (WHH of hematite, goethite, kaolinite and gibbsite; contents of hematite and goethite; aluminium substitution (AS and specific surface area (SSA of hematite and goethite; the goethite/(goethite+hematite and kaolinite/(kaolinite+gibbsite ratios; and the citrate/bicarbonate/dithionite extractable Fe (Fe d were correlated with the soil physical properties through Pearson correlation coefficients and cross-semivariograms. The correlations found between aluminium substitution in goethite and the soil physical properties suggest that the degree of crystallinity of this mineral influences soil properties used as soil quality indicators. Thus, goethite with a high aluminium substitution resulted in large aggregate sizes and a high porosity, and also in a low bulk density and soil penetration resistance. The presence of highly crystalline gibbsite resulted in a high density and micropore content, as well as in smaller aggregates. Interpretation of the cross-semivariogram and classification of landscape compartments in terms of the spatial dependence pattern for the relief-dependent physical and mineralogical properties of the soil proved an effective supplementary method for assessing Pearson correlations between the soil physical and mineralogical properties.

  14. Correlated fluorescence and 3D electron microscopy with high sensitivity and spatial precision

    Science.gov (United States)

    Kukulski, Wanda; Schorb, Martin; Welsch, Sonja; Picco, Andrea

    2011-01-01

    Correlative electron and fluorescence microscopy has the potential to elucidate the ultrastructural details of dynamic and rare cellular events, but has been limited by low precision and sensitivity. Here we present a method for direct mapping of signals originating from ∼20 fluorescent protein molecules to 3D electron tomograms with a precision of less than 100 nm. We demonstrate that this method can be used to identify individual HIV particles bound to mammalian cell surfaces. We also apply the method to image microtubule end structures bound to mal3p in fission yeast, and demonstrate that growing microtubule plus-ends are flared in vivo. We localize Rvs167 to endocytic sites in budding yeast, and show that scission takes place halfway through a 10-s time period during which amphiphysins are bound to the vesicle neck. This new technique opens the door for direct correlation of fluorescence and electron microscopy to visualize cellular processes at the ultrastructural scale. PMID:21200030

  15. Probing Multi-Strange Dibaryon with Proton-Omega Correlation in High-energy Heavy Ion Collisions

    CERN Document Server

    Morita, Kenji; Etminan, Faisal; Hatsuda, Tetsuo

    2016-01-01

    Two-particle intensity correlation between the proton ($p$) and the Omega-baryon ($\\Omega$) in high-energy heavy ion collisions is studied to unravel the possible spin-2 $p\\Omega$ dibaryon recently suggested by lattice QCD simulations. The ratio of correlation functions between small and large collision systems, $C_{\\rm SL}(Q)$, is proposed to be a new measure to extract the strong $p\\Omega$ interaction without much contamination from the Coulomb attraction. Relevance of this quantity to the experimental observables in heavy-ion collisions is also discussed.

  16. Video-gaming among high school students: health correlates, gender differences, and problematic gaming.

    Science.gov (United States)

    Desai, Rani A; Krishnan-Sarin, Suchitra; Cavallo, Dana; Potenza, Marc N

    2010-12-01

    Video game playing may negatively impact youth. However, the existing literature on gaming is inconsistent and often has focused on aggression rather than the health correlates of gaming and the prevalence and correlates of problematic gaming. We anonymously surveyed 4028 adolescents about gaming and reported problems with gaming and other health behaviors. A total of 51.2% of the sample reported gaming (76.3% of boys and 29.2% of girls). There were no negative health correlates of gaming in boys and lower odds of smoking regularly; however, girls who reported gaming were less likely to report depression and more likely to report getting into serious fights and carrying a weapon to school. Among gamers, 4.9% reported problematic gaming, defined as reporting trying to cut back, experiencing an irresistible urge to play, and experiencing a growing tension that could only be relieved by playing. Boys were more likely to report these problems (5.8%) than girls (3.0%). Correlates of problematic gaming included regular cigarette smoking, drug use, depression, and serious fights. Results suggest that gaming is largely normative in boys and not associated with many health factors. In girls, however, gaming seems to be associated with more externalizing behaviors and fewer internalizing symptoms. The prevalence of problematic gaming is low but not insignificant, and problematic gaming may be contained within a larger spectrum of externalizing behaviors. More research is needed to define safe levels of gaming, refine the definition of problematic gaming, and evaluate effective prevention and intervention strategies.

  17. Video game playing in high school students: health correlates, gender differences and problematic gaming

    Science.gov (United States)

    Desai, Rani A.; Krishnan-Sarin, Suchitra; Cavallo, Dana; Potenza, Marc N.

    2013-01-01

    There is concern about the potential for negative impact of video games on youth. However the existing literature on gaming is inconsistent and has often focused on aggression. Health correlates of gaming and the prevalence and correlates of problematic gaming have not been systematically studied. We anonymously surveyed 4,028 adolescents about gaming, reported problems with gaming, and other health behaviors. 51.2% of the sample reported gaming (76.3% of boys and 29.2% of girls). There were no negative health correlates of gaming in boys, and lower odds of smoking regularly; however, girls who reported gaming were less likely to report depression, and more likely to report getting into serious fights and carrying a weapon to school. Among gamers, 4.9% reported problematic gaming, defined as reporting trying to cut back, experiencing an irresistible urge to play, and experiencing a growing tension that could only be relieved by playing. Boys were more likely to report these problems (5.8%) than girls (3.0%). Correlates of problematic gaming included regular cigarette smoking, drug use, depression, and serious fights. Results suggest that gaming is largely normative in boys and not associated with many health factors. In girls, however, gaming appears associated with more externalizing behaviors and fewer internalizing symptoms. The prevalence of problematic gaming is low but not insignificant, and problematic gaming may be contained within a larger spectrum of externalizing behaviors. More research is needed to define safe levels of gaming, refine the definition of problematic gaming, and evaluate effective prevention and intervention strategies. PMID:21078729

  18. Linear Regression in High Dimension and/or for Correlated Inputs

    Science.gov (United States)

    Jacques, J.; Fraix-Burnet, D.

    2014-12-01

    Ordinary least square is the common way to estimate linear regression models. When inputs are correlated or when they are too numerous, regression methods using derived inputs directions or shrinkage methods can be efficient alternatives. Methods using derived inputs directions build new uncorrelated variables as linear combination of the initial inputs, whereas shrinkage methods introduce regularization and variable selection by penalizing the usual least square criterion. Both kinds of methods are presented and illustrated thanks to the R software on an astronomical dataset.

  19. Azimuthal correlations of high-transverse-momentum pi /sup 0/ pairs

    CERN Document Server

    Cobb, J H; Filippas-Tassos, A; Fowler, E C; Goldberg, M; Horwitz, N; Iwata, S; Kourkoumelis, C; Lankford, A J; Mannelli, I; Moneti, G C; Mouzourakis, P; Nakamura, K; Nappi, A; Palmer, R B; Rahm, David Charles; Rehak, R; Resvanis, L K; Struczinski, W; Stumer, I; Willis, W J

    1978-01-01

    The authors have studied correlations between two pi /sup 0/s produced at the CERN intersecting storage rings, utilizing detectors with large azimuthal acceptance. It is found that the previously observed enhancement of two pi /sup 0/s produced at azimuthal difference near 180 degrees can be made to vanish when certain kinematic effects are removed. However, it is observed that aligned configurations above 8 GeV of transverse energy are unexplained by such kinematic effects. (9 refs).

  20. Highly correlated configuration interaction calculations on water with large orbital bases

    Energy Technology Data Exchange (ETDEWEB)

    Almora-Díaz, César X., E-mail: xalmora@fisica.unam.mx [Instituto de Física, Universidad Nacional Autónoma de México, Apdo. Postal 20-364, México 01000, México (Mexico)

    2014-05-14

    A priori selected configuration interaction (SCI) with truncation energy error [C. F. Bunge, J. Chem. Phys. 125, 014107 (2006)] and CI by parts [C. F. Bunge and R. Carbó-Dorca, J. Chem. Phys. 125, 014108 (2006)] are used to approximate the total nonrelativistic electronic ground state energy of water at fixed experimental geometry with CI up to sextuple excitations. Correlation-consistent polarized core-valence basis sets (cc-pCVnZ) up to sextuple zeta and augmented correlation-consistent polarized core-valence basis sets (aug-cc-pCVnZ) up to quintuple zeta quality are employed. Truncation energy errors range between less than 1 μhartree, and 100 μhartree for the largest orbital set. Coupled cluster CCSD and CCSD(T) calculations are also obtained for comparison. Our best upper bound, −76.4343 hartree, obtained by SCI with up to sextuple excitations with a cc-pCV6Z basis recovers more than 98.8% of the correlation energy of the system, and it is only about 3 kcal/mol above the “experimental” value. Despite that the present energy upper bounds are far below all previous ones, comparatively large dispersion errors in the determination of the extrapolated energies to the complete basis set do not allow to determine a reliable estimation of the full CI energy with an accuracy better than 0.6 mhartree (0.4 kcal/mol)

  1. Digital Signal Processing using Stream High Performance Computing: A 512-input Broadband Correlator for Radio Astronomy

    CERN Document Server

    Kocz, J; Barsdell, B R; Price, D; Bernardi, G; Bourke, S; Clark, M A; Craig, J; Dexter, M; Dowell, J; Eftekhari, T; Ellingson, S; Hallinan, G; Hartman, J; Jameson, A; MacMahon, D; Taylor, G; Schinzel, F; Werthimer, D

    2014-01-01

    A "large-N" correlator that makes use of Field Programmable Gate Arrays and Graphics Processing Units has been deployed as the digital signal processing system for the Long Wavelength Array station at Owens Valley Radio Observatory (LWA-OV), to enable the Large Aperture Experiment to Detect the Dark Ages (LEDA). The system samples a ~100MHz baseband and processes signals from 512 antennas (256 dual polarization) over a ~58MHz instantaneous sub-band, achieving 16.8Tops/s and 0.236 Tbit/s throughput in a 9kW envelope and single rack footprint. The output data rate is 260MB/s for 9 second time averaging of cross-power and 1 second averaging of total-power data. At deployment, the LWA-OV correlator was the largest in production in terms of N and is the third largest in terms of complex multiply accumulations, after the Very Large Array and Atacama Large Millimeter Array. The correlator's comparatively fast development time and low cost establish a practical foundation for the scalability of a modular, heterogeneo...

  2. Effects of high-order correlations on personalized recommendations for bipartite networks

    Science.gov (United States)

    Liu, Jian-Guo; Zhou, Tao; Che, Hong-An; Wang, Bing-Hong; Zhang, Yi-Cheng

    2010-02-01

    In this paper, we introduce a modified collaborative filtering (MCF) algorithm, which has remarkably higher accuracy than the standard collaborative filtering. In the MCF, instead of the cosine similarity index, the user-user correlations are obtained by a diffusion process. Furthermore, by considering the second-order correlations, we design an effective algorithm that depresses the influence of mainstream preferences. Simulation results show that the algorithmic accuracy, measured by the average ranking score, is further improved by 20.45% and 33.25% in the optimal cases of MovieLens and Netflix data. More importantly, the optimal value λ depends approximately monotonously on the sparsity of the training set. Given a real system, we could estimate the optimal parameter according to the data sparsity, which makes this algorithm easy to be applied. In addition, two significant criteria of algorithmic performance, diversity and popularity, are also taken into account. Numerical results show that as the sparsity increases, the algorithm considering the second-order correlation can outperform the MCF simultaneously in all three criteria.

  3. COPD in HIV-Infected Patients: CD4 Cell Count Highly Correlated

    Science.gov (United States)

    Guillouet-de-Salvador, Francine; Valerio, Laure; Puglièse, Pascal; Naqvi, Alissa; Durant, Jacques; Demonchy, Elisa; Perbost, Isabelle; Cua, Eric; Marquette, Charles-Hugo; Roger, Pierre-Marie

    2017-01-01

    Background COPD is a frequent and significant cause of respiratory morbidity in HIV-infected patients despite the control of HIV. We aimed to analyze the factors correlated with COPD in this population to evaluate the existence of specific indicators of vulnerability in this population. Methods and Findings 623 HIV-infected outpatients were enrolled during one year. This population was characterised by a dedicated questionnaire and electronic patient records. COPD screening was performed according to recommended spirometric criteria. The prevalence of COPD was 9.0%. Age and smoking were independently correlated with COPD (OR, 1.61 per 10 years increase, P = 0.007; OR, 1.28 per 10 pack-year increase, P = 0.003, respectively). Body mass index (BMI) and CD4 cell-count were independently and negatively correlated with COPD (OR, 0.78, P tobacco-smoking and respiratory complaints with a particular concern toward patients with a profound CD4 cell count defect. PMID:28056048

  4. The correlation between highly sensitive C-reactive protein levels and erectile function among men with late-onset hypogonadism.

    Science.gov (United States)

    Shigehara, Kazuyoshi; Konaka, Hiroyuki; Ijima, Masashi; Nohara, Takahiro; Narimoto, Kazutaka; Izumi, Koji; Kadono, Yoshifumi; Kitagawa, Yasuhide; Mizokami, Atsushi; Namiki, Mikio

    2016-12-01

    We investigated the correlation between highly sensitive C-reactive protein (hs-CRP) levels and erectile function, and assessed the clinical role of hs-CRP levels in men with late-onset hypogonadism (LOH) syndrome. For 77 participants, we assessed Sexual Health Inventory for men (SHIM) score, Aging Male Symptoms (AMS) score and International Prostate Symptom Score (IPSS). We also evaluated free testosterone (FT), hs-CRP, total cholesterol, triglyceride levels, high density lipoprotein cholesterol, hemoglobin A1c, body mass index, waist size and blood pressure. We attempted to identify parameters correlated with SHIM score and to determine the factors affecting cardiovascular risk based on hs-CRP levels. A Spearman rank correlation test revealed that age, AMS score, IPSS and hs-CRP levels were significantly correlated with SHIM score. Age-adjusted analysis revealed that hs-CRP and IPSS were the independent factors affecting SHIM score (r= -0.304 and -0.322, respectively). Seventeen patients belonged to the moderate to high risk group for cardiovascular disease, whereas the remaining 60 belonged to the low risk group. Age, FT value and SHIM score showed significant differences between the two groups. A multivariate regression analysis demonstrated that SHIM score was an independent factor affecting cardiovascular risk (OR: 0.796; 95%CI: 0.637-0.995).

  5. Pareto分布的Pearson-χ2距离%The Study of Pearson-χ2 Distance for Gamma Distribution

    Institute of Scientific and Technical Information of China (English)

    季海波

    2016-01-01

    The Pareto distribution Pa(θ,a) is studied, and the expression of Pearson-χ2 distance between two Pareto distributions was given.For two different parameters, it sets the Pearson-χ2 maximum distance between two Pareto distributions.Moreover, with the same parameter a , it was also discussed..%对Pareto分布Pa(θ,a)进行研究,给出两个Pareto分布之间的Pearson-χ2距离的表达式。在两个参数都不同的情况下,得到了两个Pareto分布之间Pearson-χ2的最大距离。此外,在尺度参数a相同情况下,讨论了两个Pareto分布间的最大距离。

  6. Ajuste da função log-Pearson tipo III a dados de povoamentos equiâneos de eucalipto

    OpenAIRE

    Binoti,Daniel Henrique Breda; Binoti,Mayra Luiza Marques da Silva; Leite,Helio Garcia; Matos,Luiz Marcos Silva; Silva,Antonilmar Araújo Lopes da

    2014-01-01

    Objetivou-se, neste estudo, avaliar a eficiência da função log-Pearson tipo III para a descrição da estrutura diamétrica de povoamentos equiâneos, bem como propor um modelo de distribuição diamétrica utilizando a função. A modelagem realizada pela função log-Pearson tipo III foi comparada com a modelagem realizada com a função Weibull. Para isso, utilizaram-se dados de parcelas permanentes de eucalipto, localizadas na região Centro Oeste do Estado de Minas Gerais. Os modelos de distribuição d...

  7. Estimation of rank correlation for clustered data.

    Science.gov (United States)

    Rosner, Bernard; Glynn, Robert J

    2017-06-30

    It is well known that the sample correlation coefficient (Rxy ) is the maximum likelihood estimator of the Pearson correlation (ρxy ) for independent and identically distributed (i.i.d.) bivariate normal data. However, this is not true for ophthalmologic data where X (e.g., visual acuity) and Y (e.g., visual field) are available for each eye and there is positive intraclass correlation for both X and Y in fellow eyes. In this paper, we provide a regression-based approach for obtaining the maximum likelihood estimator of ρxy for clustered data, which can be implemented using standard mixed effects model software. This method is also extended to allow for estimation of partial correlation by controlling both X and Y for a vector U_ of other covariates. In addition, these methods can be extended to allow for estimation of rank correlation for clustered data by (i) converting ranks of both X and Y to the probit scale, (ii) estimating the Pearson correlation between probit scores for X and Y, and (iii) using the relationship between Pearson and rank correlation for bivariate normally distributed data. The validity of the methods in finite-sized samples is supported by simulation studies. Finally, two examples from ophthalmology and analgesic abuse are used to illustrate the methods. Copyright © 2017 John Wiley & Sons, Ltd. Copyright © 2017 John Wiley & Sons, Ltd.

  8. A new interpretation of the far-infrared - radio correlation and the expected breakdown at high redshift

    CERN Document Server

    Schleicher, Dominik R G

    2013-01-01

    (Abrigded) Observations of galaxies up to z 2 show a tight correlation between far-infrared and radio continuum emission. We explain the far-infrared - radio continuum correlation by relating star formation and magnetic field strength in terms of turbulent magnetic field amplification, where turbulence is injected by supernova explosions from massive stars. We calculate the expected amount of turbulence in galaxies based on their star formation rates, and infer the expected magnetic field strength due to turbulent dynamo amplification. We estimate the timescales for cosmic ray energy losses via synchrotron emission, inverse Compton scattering, ionization and bremsstrahlung emission, probing up to which redshift strong synchrotron emission can be maintained. We find that the correlation between star formation rate and magnetic field strength in the local Universe can be understood as a result of turbulent magnetic field amplification. If the typical gas density in the interstellar medium increases at high z, w...

  9. COMPARISON OF COEFFICIENTS AMONG POLY CHORIC CORRELATION,PEARSON CORRELATION AND RANK CORRELATION OF RANK DATA%等级资料的多项相关、直线相关及秩相关系数的比较

    Institute of Scientific and Technical Information of China (English)

    陈炳为; 许碧云

    2009-01-01

    [目的]探讨具有连续型潜在变量的等级变量间多项相关系数、Pearson相关系数、秩相关系数间的关系.[方法]利用SAS统计软件产生样本数为10 000的双变量正态分布,并将其转换成等级资料,分别求得其秩相关系数、Pearson相关系数及多项相关系数.[结果]存在正态分布潜在变量的等级资料的多项相关系数要比Pearson及秩相关系数更为接近实际的相关水平,特别当相关系数较大时,Pearson相关和秩相关系数与实际的偏差较大.[结论]多项相关系数受分级的影响不大,而Pearson相关和秩相关系数均受到分级的影响.

  10. Sequential change of fibrosing alveolitis on high-resolution CT: correlation with finding at pulmonary function test and bronchoalveolar lavage

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Min Soo; Kim, Yang Hee; Kim, Sae Hun [College of Medicine, Soonchunhyang University, Seoul (Korea, Republic of)] (and others)

    1995-08-15

    To evaluate prospectively relationship between the extent of abnormalities of fibrosing alveolotro on high resolution CT and these of pulmonary function test, and bronchoalveolar lavage. This study included 27 patients with pathologically proved UIP. We prospectively analyzed correlation of the extent of ground glass opacity, consolidation, irregular lines with honeycombing on initial CT scan and quantitative change of ground glass opacity on follow up CT scans with pulmonary function test(PFT) and bronchoalveolar lavage(BAL). On initial CT scan, score of extent of disease significantly correlated with FEV1(r = -0.5148, {rho} = 0.0310) and DLco(r -0.7102, {rho} = 0.0001). Proportion of individual cell in BAL was not correlated with ground glass opacity or extent of disease; lymphocyte({rho} -0.0165, r = 0.9616), eosinophil ({rho} = -0.0077, r = 0.9832), neutrophil ({rho} = -0.1732, r = 0.5903). On follow up CT scan, quantitative change of ground glass opacity correlated with DLco/VA(r = -0.6825, {rho} = 0.0025) and TLC (r = 0.5248, {rho} = 0.0429). The quantitative analysis of extent of disease on HRCT in useful for evaluation of clinical status. Also change of ground glass opacity on follow-up HRCT significantly correlated with improvement of diffusing capacity in fibrosing alveolitis.

  11. High-energy spin-density-wave correlated fluctuations in paramagnetic Cr + 5 at. % V

    Energy Technology Data Exchange (ETDEWEB)

    Werner, S.A. (Missouri Univ., Columbia, MO (United States). Dept. of Physics); Fawcett, E. (Toronto Univ., ON (Canada). Dept. of Physics); Elmiger, M.W.; Shirane, G. (Brookhaven National Lab., Upton, NY (United States))

    1992-01-01

    Measurements of the magnetic fluctuations, termed spin-density-wave (SDW) paramagnons, in the nearly antiferromagnetic alloy Cr + 5 at.%V are extended up in energy to about 80 MeV. These fluctuating spin-spin correlations occur at incommensurate positions, corresponding to the SDW wavevector Q. Their characteristic energy is at least an order of magnitude larger than that of the magnetic fluctuations seen in the paramagnetic phase of pure Cr, but their intensity is more than two orders of magnitude smaller. We find that the dynamic susceptibility decreases by about 50% between temperature T = 10K and 300K.

  12. High-energy spin-density-wave correlated fluctuations in paramagnetic Cr + 5 at. % V

    Energy Technology Data Exchange (ETDEWEB)

    Werner, S.A. [Missouri Univ., Columbia, MO (United States). Dept. of Physics; Fawcett, E. [Toronto Univ., ON (Canada). Dept. of Physics; Elmiger, M.W.; Shirane, G. [Brookhaven National Lab., Upton, NY (United States)

    1992-11-01

    Measurements of the magnetic fluctuations, termed spin-density-wave (SDW) paramagnons, in the nearly antiferromagnetic alloy Cr + 5 at.%V are extended up in energy to about 80 MeV. These fluctuating spin-spin correlations occur at incommensurate positions, corresponding to the SDW wavevector Q. Their characteristic energy is at least an order of magnitude larger than that of the magnetic fluctuations seen in the paramagnetic phase of pure Cr, but their intensity is more than two orders of magnitude smaller. We find that the dynamic susceptibility decreases by about 50% between temperature T = 10K and 300K.

  13. Expression of the Arabidopsis high-affinity hexose transporter STP13 correlates with programmed cell death

    DEFF Research Database (Denmark)

    Nørholm, Morten Helge Hauberg; Nour-Eldin, Hussam H; Brodersen, Peter;

    2006-01-01

    GFP expression only in the vascular tissue in emerging petals under non-stressed conditions. Quantitative PCR and the pSTP13-GFP plants show induction of STP13 in programmed cell death (PCD) obtained by treatments with the fungal toxin fumonisin B1 and the pathogen Pseudomonas syringae. A role for STP......13 in PCD is supported by microarray data from e.g. plants undergoing senescence and a strong correlation between STP13 transcripts and the PCD phenotype in different accelerated cell death (acd11) mutants....

  14. Simple characterizations of comontonocity and countermonotonocity by extremal correlations

    NARCIS (Netherlands)

    Denuit, M.; Dhaene, J.

    2003-01-01

    In this pedagogical note, it is shown how extremal values of classical measures of association like Pearson's correlation coefficient, Kendall's τ, Spearman's ρ and Gini's γ, characterize comonotonicity and countermonotonicity. The link between zero-correlation and mutual independence is also examin

  15. Statistical correlations for thermophysical properties of Supercritical Argon (SCAR) used in cooling of futuristic High Temperature Superconducting (HTS) cables

    Energy Technology Data Exchange (ETDEWEB)

    Kalsia, Mohit [School of Mechanical Engineering, Lovely Professional University, Phagwara, 144 401 (India); Dondapati, Raja Sekhar, E-mail: drsekhar@ieee.org [School of Mechanical Engineering, Lovely Professional University, Phagwara, 144 401 (India); Usurumarti, Preeti Rao [Department of Mechanical Engineering, PVK Institute of Technology, Anantpur, 515 001 (India)

    2017-05-15

    Highlights: • The developed correlations can be integrated into thermohydraulic analysis of HTS cables. • This work also explains the phenomenon of flow with less pumping power and maximum heat transfer in HTS cables. • Pumping power required to circulate the SCAR for cooling of HTS cables would be significantly lower. • For Hg-based high temperature superconductors (T{sub c} > 134 K), SCAR found to be a suitable coolant. - Abstract: High Temperature Superconducting (HTS) cables are emerging as an alternative to conventional cables in efficient power transmission. However, these HTS cables require cooling below the critical temperature of superconductors used to transmit larger currents. With the invention of high temperature superconductors whose critical temperatures are up to 134 K (Hg based), it is a great challenge to identify a suitable coolant which can carry away the heating load on the superconductors. In order to accomplish such challenge, an attempt has been made in the present work to propose supercritical Argon (SCAR) as the alternative to cool the HTS cables. Further, a statistical correlation has been developed for the thermophysical properties such as density, viscosity, specific heat and thermal conductivity of SCAR. In addition, the accuracy of developed correlations is established with the help of few statistical parameters and validated with standard database available in the literature. These temperature dependent accurate correlations are useful in predicting the pressure drop and heat transfer behaviour in HTS cables using numerical or computational techniques. In recent times, with the sophistication of computer technology, solving of various complex transport equations along with the turbulence models became popular and hence the developed correlations would benefit the technological community. It is observed that, a decrease in pressure, density and viscosity are found to be decreasing whereas the thermal conductivity and specific

  16. Statistical correlations for thermophysical properties of Supercritical Argon (SCAR) used in cooling of futuristic High Temperature Superconducting (HTS) cables

    Science.gov (United States)

    Kalsia, Mohit; Dondapati, Raja Sekhar; Usurumarti, Preeti Rao

    2017-05-01

    High Temperature Superconducting (HTS) cables are emerging as an alternative to conventional cables in efficient power transmission. However, these HTS cables require cooling below the critical temperature of superconductors used to transmit larger currents. With the invention of high temperature superconductors whose critical temperatures are up to 134 K (Hg based), it is a great challenge to identify a suitable coolant which can carry away the heating load on the superconductors. In order to accomplish such challenge, an attempt has been made in the present work to propose supercritical Argon (SCAR) as the alternative to cool the HTS cables. Further, a statistical correlation has been developed for the thermophysical properties such as density, viscosity, specific heat and thermal conductivity of SCAR. In addition, the accuracy of developed correlations is established with the help of few statistical parameters and validated with standard database available in the literature. These temperature dependent accurate correlations are useful in predicting the pressure drop and heat transfer behaviour in HTS cables using numerical or computational techniques. In recent times, with the sophistication of computer technology, solving of various complex transport equations along with the turbulence models became popular and hence the developed correlations would benefit the technological community. It is observed that, a decrease in pressure, density and viscosity are found to be decreasing whereas the thermal conductivity and specific heat increase significantly. It can be concluded that higher heat transfer rate and lower pumping power can be achieved with SCAR as coolant in the HTS cables.

  17. Searches for correlation between UHECR events and high-energy gamma-ray Fermi-LAT data

    CERN Document Server

    Alvarez, Ezequiel; Mirabal, Nestor; Zaharijas, Gabrijela

    2016-01-01

    The astrophysical sources responsible for ultra high-energy cosmic rays (UHECRs) continue to be one of the most intriguing mysteries in astrophysics. We present a comprehensive search for correlations between high-energy ($\\gtrapprox 1$ GeV) gamma-ray events from the Fermi Large Area Telescope (LAT) and UHECRs ($\\gtrapprox 60$ EeV) detected by the Telescope Array and the Pierre Auger Observatory. We perform two separate searches. First, we conduct a standard cross-correlation analysis between the arrival directions of 148 UHECRs and 360 gamma-ray sources in the Second Catalog of Hard Fermi-LAT sources (2FHL). Second, we search for a possible correlation between UHECR directions and unresolved Fermi-LAT gamma-ray emission. For the latter, we use three different methods: a stacking technique with both a model-dependent and model-independent background estimate, and a cross-correlation function analysis. We also test for statistically significant excesses in gamma rays from signal regions centered on Cen A and t...

  18. A comparative study of friction factor correlations for high concentrate slurry flow in smooth pipes

    Directory of Open Access Journals (Sweden)

    Assefa K. M.

    2015-03-01

    Full Text Available A number of correlations for friction factor determinations in smooth pipes have been proposed in the past decades. The accuracy and applicability of these friction factor formulas should be examined. Based on this notion the paper is designed to provide a comparative study of friction factor correlations in smooth pipes for all flow regimes of Bingham fluids. Nine models were chosen. The comparisons of the selected equations with the existing experimental results, which are available in the literature, were expressed through MARE, MRE+, MRE-, RMSE, Ѳ, and S. The statistical comparisons were also carried out using MSC and AIC. The analyses show that the Wilson-Thomas (1985 and Morrison (2013 models are best fit models to the experimental data for the Reynolds number up to 40000. Within this range, both models can be used alternately. But beyond this Re value the discrepancy of the Wilson-Thomas model is higher than the Morrison model. In view of the fact that the Morrison model requires fewer calculations and parameters as well as a single equation is used to compute the friction factor for all flow regimes, it is the authors’ advice to use this model for friction factor estimation for the flow of Bingham fluids in smooth pipes as an alternative to the Moody chart and other implicit formulae.

  19. Obesity and Other Correlates of Physical Activity and Sedentary Behaviors among US High School Students

    Directory of Open Access Journals (Sweden)

    Richard Lowry

    2013-01-01

    Full Text Available Understanding correlates of physical activity (PA can help inform and improve programs that promote PA among youth. We analyzed data from the 2010 National Youth Physical Activity and Nutrition Study, a representative sample of US students in grades 9–12. Logistic regression was used to examine associations between PA correlates (obesity, physical education classes, sports team participation, attitude toward PA, adult support for PA, and environmental support for PA and participation in daily PA (DPA, vigorous PA (VPA, muscle-strengthening activity (MSA, viewing television (TV, and using computers or video games (C/VG. A positive attitude toward PA and adult support for PA were both associated with increased PA and decreased sedentary behavior. However, among students who lived in neighborhoods that were not safe for PA, a positive attitude toward PA was not associated with increased DPA or decreased sedentary behavior and was less strongly associated with VPA and MSA. Efforts to increase PA among youth should promote a positive attitude toward PA among youth and encourage adult family members to support their efforts to be active. Policies that promote safe neighborhoods may work synergistically with a positive attitude toward PA to increase participation in PA and decrease sedentary behaviors.

  20. Obesity and Other Correlates of Physical Activity and Sedentary Behaviors among US High School Students

    Science.gov (United States)

    Lowry, Richard; Lee, Sarah M.; Fulton, Janet E.; Demissie, Zewditu; Kann, Laura

    2013-01-01

    Understanding correlates of physical activity (PA) can help inform and improve programs that promote PA among youth. We analyzed data from the 2010 National Youth Physical Activity and Nutrition Study, a representative sample of US students in grades 9–12. Logistic regression was used to examine associations between PA correlates (obesity, physical education classes, sports team participation, attitude toward PA, adult support for PA, and environmental support for PA) and participation in daily PA (DPA), vigorous PA (VPA), muscle-strengthening activity (MSA), viewing television (TV), and using computers or video games (C/VG). A positive attitude toward PA and adult support for PA were both associated with increased PA and decreased sedentary behavior. However, among students who lived in neighborhoods that were not safe for PA, a positive attitude toward PA was not associated with increased DPA or decreased sedentary behavior and was less strongly associated with VPA and MSA. Efforts to increase PA among youth should promote a positive attitude toward PA among youth and encourage adult family members to support their efforts to be active. Policies that promote safe neighborhoods may work synergistically with a positive attitude toward PA to increase participation in PA and decrease sedentary behaviors. PMID:23606950

  1. High clusterin expression correlates with a poor outcome in stage II colorectal cancers.

    LENUS (Irish Health Repository)

    Kevans, David

    2012-02-01

    The role of clusterin in tumor growth and progression remains unclear. Overexpression of cytoplasmic clusterin has been studied in aggressive colon tumors; however, no correlation between clusterin expression and survival in colorectal cancer has been identified to date. We assessed levels of clusterin expression in a group of stage II colorectal cancer patients to assess its utility as a prognostic marker. The study included 251 patients with stage II colorectal cancer. Tissue microarrays were constructed and immunohistochemistry done and correlated with clinical features and long term outcome. Dual immunofluorescence and confocal microscopy were used with terminal deoxynucleotidyl-transferase-mediated dUTP nick-end labeling probes and clusterin antibody to assess the degree of co localization. Percentage epithelial cytoplasmic staining was higher in tumor compared with nonadjacent normal mucosa (P < 0.001). Within the stromal compartment, percentage cytoplamic staining and intensity was lower in tumor tissue compared with normal nonadjacent mucosa (P < or = 0.001). Survival was significantly associated with percentage epithelial cytoplasmic staining (P < 0.001), epithelial cytoplasmic staining intensity (P < 0.001), percentage stromal cytoplasmic staining (P = 0.002), and stromal cytoplasmic staining intensity (P < 0.001). Clusterin levels are associated with poor survival in stage II colorectal cancer.

  2. Cross correlation calculations and neutron scattering analysis for a portable solid state neutron detection system

    Science.gov (United States)

    Saltos, Andrea

    In efforts to perform accurate dosimetry, Oakes et al. [Nucl. Intrum. Mehods. (2013)] introduced a new portable solid state neutron rem meter based on an adaptation of the Bonner sphere and the position sensitive long counter. The system utilizes high thermal efficiency neutron detectors to generate a linear combination of measurement signals that are used to estimate the incident neutron spectra. The inversion problem associated to deduce dose from the counts in individual detector elements is addressed by applying a cross-correlation method which allows estimation of dose with average errors less than 15%. In this work, an evaluation of the performance of this system was extended to take into account new correlation techniques and neutron scattering contribution. To test the effectiveness of correlations, the Distance correlation, Pearson Product-Moment correlation, and their weighted versions were performed between measured spatial detector responses obtained from nine different test spectra, and the spatial response of Library functions generated by MCNPX. Results indicate that there is no advantage of using the Distance Correlation over the Pearson Correlation, and that weighted versions of these correlations do not increase their performance in evaluating dose. Both correlations were proven to work well even at low integrated doses measured for short periods of time. To evaluate the contribution produced by room-return neutrons on the dosimeter response, MCNPX was used to simulate dosimeter responses for five isotropic neutron sources placed inside different sizes of rectangular concrete rooms. Results show that the contribution of scattered neutrons to the response of the dosimeter can be significant, so that for most cases the dose is over predicted with errors as large as 500%. A possible method to correct for the contribution of room-return neutrons is also assessed and can be used as a good initial estimate on how to approach the problem.

  3. Thoracic Idiopathic Scoliosis Severity Is Highly Correlated with 3D Measures of Thoracic Kyphosis.

    Science.gov (United States)

    Sullivan, T Barrett; Reighard, Fredrick G; Osborn, Emily J; Parvaresh, Kevin C; Newton, Peter O

    2017-06-07

    Loss of thoracic kyphosis has been associated with thoracic idiopathic scoliosis. Modern 3-dimensional (3D) imaging systems allow more accurate characterization of the scoliotic deformity than traditional radiographs. In this study, we utilized 3D calculations to characterize the association between increasing scoliosis severity and changes in the sagittal and axial planes. Patients evaluated in a scoliosis clinic and determined to have either a normal spine or idiopathic scoliosis were included in the analysis. All underwent upright, biplanar radiography with 3D reconstructions. Two-dimensional (2D) measurements of the magnitude of the thoracic major curve and the thoracic kyphosis were recorded. Image processing and MATLAB analysis were utilized to produce a 3D calculation of thoracic kyphosis and apical vertebral axial rotation. Regression analysis was performed to determine the correlation of 2D kyphosis, 3D kyphosis, and apical axial rotation with the magnitude of the thoracic major curve. The 442 patients for whom 2D and 3D data were collected had a main thoracic curve magnitude ranging from 1° to 118°. Linear regression analysis of the 2D and 3D T5-T12 kyphosis versus main thoracic curve magnitude yielded significant models (p scoliosis magnitude increased, at a rate of more than half the increase in the main thoracic curve magnitude. Analysis confirmed a surprisingly strong correlation between scoliosis severity and loss of 3D kyphosis that was absent in the 2D analysis. A similarly strong correlation between curve magnitude and apical axial rotation was evident. These findings lend further credence to the concept that scoliosis progresses in the coronal, sagittal, and axial planes simultaneously. The findings of this study suggest that 3D assessment is critical for adequate characterization of the multiplanar deformity of idiopathic scoliosis and deformity in the sagittal plane is linked to deformity in the coronal plane. Increasing severity of coronal

  4. Statistical-noise reduction in correlation analysis of high-energy nuclear collisions with event-mixing

    CERN Document Server

    Ray, R L

    2016-01-01

    The error propagation and statistical-noise reduction method of Reid and Trainor for two-point correlation applications in high-energy collisions is extended to include particle-pair references constructed by mixing two particles from all event-pair combinations within event subsets of arbitrary size. The Reid-Trainor method is also applied to other particle-pair mixing algorithms commonly used in correlation analysis of particle production from high-energy nuclear collisions. The statistical-noise reduction, inherent in the Reid-Trainor event-mixing procedure, is shown to occur for these other event-mixing algorithms as well. Monte Carlo simulation results are presented which verify the predicted degree of noise reduction. In each case the final errors are determined by the bin-wise particle-pair number, rather than by the bin-wise single-particle count.

  5. Advanced Taste Sensors Based on Artificial Lipids with Global Selectivity to Basic Taste Qualities and High Correlation to Sensory Scores

    Directory of Open Access Journals (Sweden)

    Yoshikazu Kobayashi

    2010-04-01

    Full Text Available Effective R&D and strict quality control of a broad range of foods, beverages, and pharmaceutical products require objective taste evaluation. Advanced taste sensors using artificial-lipid membranes have been developed based on concepts of global selectivity and high correlation with human sensory score. These sensors respond similarly to similar basic tastes, which they quantify with high correlations to sensory score. Using these unique properties, these sensors can quantify the basic tastes of saltiness, sourness, bitterness, umami, astringency and richness without multivariate analysis or artificial neural networks. This review describes all aspects of these taste sensors based on artificial lipid, ranging from the response principle and optimal design methods to applications in the food, beverage, and pharmaceutical markets.

  6. Statistical-noise reduction in correlation analysis of high-energy nuclear collisions with event-mixing

    Energy Technology Data Exchange (ETDEWEB)

    Ray, R.L., E-mail: ray@physics.utexas.edu; Bhattarai, P.

    2016-06-11

    The error propagation and statistical-noise reduction method of Reid and Trainor for two-point correlation applications in high-energy collisions is extended to include particle-pair references constructed by mixing two particles from all event-pair combinations within event subsets of arbitrary size. The Reid–Trainor method is also applied to other particle-pair mixing algorithms commonly used in correlation analysis of particle production from high-energy nuclear collisions. The statistical-noise reduction, inherent in the Reid–Trainor event-mixing procedure, is shown to occur for these other event-mixing algorithms as well. Monte Carlo simulation results are presented which verify the predicted degree of noise reduction. In each case the final errors are determined by the bin-wise particle-pair number, rather than by the bin-wise single-particle count.

  7. Implementation of the Two-Point Angular Correlation Function on a High-Performance Reconfigurable Computer

    Directory of Open Access Journals (Sweden)

    Volodymyr V. Kindratenko

    2009-01-01

    Full Text Available We present a parallel implementation of an algorithm for calculating the two-point angular correlation function as applied in the field of computational cosmology. The algorithm has been specifically developed for a reconfigurable computer. Our implementation utilizes a microprocessor and two reconfigurable processors on a dual-MAP SRC-6 system. The two reconfigurable processors are used as two application-specific co-processors. Two independent computational kernels are simultaneously executed on the reconfigurable processors while data pre-fetching from disk and initial data pre-processing are executed on the microprocessor. The overall end-to-end algorithm execution speedup achieved by this implementation is over 90× as compared to a sequential implementation of the algorithm executed on a single 2.8 GHz Intel Xeon microprocessor.

  8. Entanglement versus Stosszahlansatz: disappearance of the thermodynamic arrow in a high-correlation environment.

    Science.gov (United States)

    Partovi, M Hossein

    2008-02-01

    The crucial role of ambient correlations in determining thermodynamic behavior is established. A class of entangled states of two macroscopic systems is constructed such that each component is in a state of thermal equilibrium at a given temperature, and when the two are allowed to interact heat can flow from the colder to the hotter system. A dilute gas model exhibiting this behavior is presented. This reversal of the thermodynamic arrow is a consequence of the entanglement between the two systems, a condition that is opposite to molecular chaos and shown to be unlikely in a low-entropy environment. By contrast, the second law is established by proving Clausius' inequality in a low-entropy environment. These general results strongly support the expectation, first expressed by Boltzmann and subsequently elaborated by others, that the second law is an emergent phenomenon which requires a low-entropy cosmological environment, one that can effectively function as an ideal information sink.

  9. Benchmarking exchange-correlation functionals for hydrogen at high pressures using quantum Monte Carlo

    Energy Technology Data Exchange (ETDEWEB)

    Clay, Raymond C. [Univ. of Illinois, Urbana, IL (United States); Mcminis, Jeremy [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); McMahon, Jeffrey M. [Univ. of Illinois, Urbana, IL (United States); Pierleoni, Carlo [Istituto Nazionale di Fisica Nucleare (INFN), L' aquila (Italy). Lab. Nazionali del Gran Sasso (INFN-LNGS); Ceperley, David M. [Univ. of Illinois, Urbana, IL (United States); Morales, Miguel A. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2014-05-01

    The ab initio phase diagram of dense hydrogen is very sensitive to errors in the treatment of electronic correlation. Recently, it has been shown that the choice of the density functional has a large effect on the predicted location of both the liquid-liquid phase transition and the solid insulator-to-metal transition in dense hydrogen. To identify the most accurate functional for dense hydrogen applications, we systematically benchmark some of the most commonly used functionals using quantum Monte Carlo. By considering several measures of functional accuracy, we conclude that the van der Waals and hybrid functionals significantly outperform local density approximation and Perdew-Burke-Ernzerhof. We support these conclusions by analyzing the impact of functional choice on structural optimization in the molecular solid, and on the location of the liquid-liquid phase transition.

  10. Prediction of broadband ground-motion time histories: Hybrid low/high-frequency method with correlated random source parameters

    Science.gov (United States)

    Liu, P.; Archuleta, R.J.; Hartzell, S.H.

    2006-01-01

    We present a new method for calculating broadband time histories of ground motion based on a hybrid low-frequency/high-frequency approach with correlated source parameters. Using a finite-difference method we calculate low- frequency synthetics (3D velocity structure. We also compute broadband synthetics in a 1D velocity model using a frequency-wavenumber method. The low frequencies from the 3D calculation are combined with the high frequencies from the 1D calculation by using matched filtering at a crossover frequency of 1 Hz. The source description, common to both the 1D and 3D synthetics, is based on correlated random distributions for the slip amplitude, rupture velocity, and rise time on the fault. This source description allows for the specification of source parameters independent of any a priori inversion results. In our broadband modeling we include correlation between slip amplitude, rupture velocity, and rise time, as suggested by dynamic fault modeling. The method of using correlated random source parameters is flexible and can be easily modified to adjust to our changing understanding of earthquake ruptures. A realistic attenuation model is common to both the 3D and 1D calculations that form the low- and high-frequency components of the broadband synthetics. The value of Q is a function of the local shear-wave velocity. To produce more accurate high-frequency amplitudes and durations, the 1D synthetics are corrected with a randomized, frequency-dependent radiation pattern. The 1D synthetics are further corrected for local site and nonlinear soil effects by using a 1D nonlinear propagation code and generic velocity structure appropriate for the site’s National Earthquake Hazards Reduction Program (NEHRP) site classification. The entire procedure is validated by comparison with the 1994 Northridge, California, strong ground motion data set. The bias and error found here for response spectral acceleration are similar to the best results that have been

  11. Standardization of a fluconazole bioassay and correlation of results with those obtained by high-pressure liquid chromatography.

    OpenAIRE

    Rex, J H; Hanson, L H; Amantea, M A; Stevens, D.A.; BENNETT,J.E.

    1991-01-01

    An improved bioassay for fluconazole was developed. This assay is sensitive in the clinically relevant range (2 to 40 micrograms/ml) and analyzes plasma, serum, and cerebrospinal fluid specimens; bioassay results correlate with results obtained by high-pressure liquid chromatography (HPLC). Bioassay and HPLC analyses of spiked plasma, serum, and cerebrospinal fluid samples (run as unknowns) gave good agreement with expected values. Analysis of specimens from patients gave equivalent results b...

  12. Self-injury, suicide ideation, and sexual orientation: differences in causes and correlates among high school students

    OpenAIRE

    Whitney DeCamp; Bakken, Nicholas W.

    2016-01-01

    Abstract: Background: Research has suggested that sexual minority youth are more likely to experience a number of behavioral and health-related risk factors due to their exposure to negative attitudes and beliefs about sexual minorities. Few studies, however, have examined the prevalence of non-suicidal self-injury (NSSI) among sexual minority youth. With self-cutting and suicidal ideation common in middle and high schools, understanding the antecedents and correlates of such behavior may hel...

  13. Biological correlates of blood pressure variability in elderly at high risk of cardiovascular disease.

    Science.gov (United States)

    Poortvliet, Rosalinde K E; Lloyd, Suzanne M; Ford, Ian; Sattar, Naveed; de Craen, Anton J M; Wijsman, Liselotte W; Mooijaart, Simon P; Westendorp, Rudi G J; Jukema, J Wouter; de Ruijter, Wouter; Gussekloo, Jacobijn; Stott, David J

    2015-04-01

    Visit-to-visit variability in blood pressure is an independent predictor of cardiovascular disease. This study investigates biological correlates of intra-individual variability in blood pressure in older persons. Nested observational study within the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER) among 3,794 male and female participants (range 70-82 years) with a history of, or risk factors for cardiovascular disease. Individual visit-to-visit variability in systolic and diastolic blood pressure and pulse pressure (expressed as 1 SD in mm Hg) was assessed using nine measurements over 2 years. Correlates of higher visit-to-visit variability were examined at baseline, including markers of inflammation, endothelial function, renal function and glucose homeostasis. Over the first 2 years, the mean intra-individual variability (1 SD) was 14.4mm Hg for systolic blood pressure, 7.7mm Hg for diastolic blood pressure, and 12.6mm Hg for pulse pressure. After multivariate adjustment a higher level of interleukin-6 at baseline was consistently associated with higher intra-individual variability of blood pressure, including systolic, diastolic, and pulse pressure. Markers of endothelial function (Von Willebrand factor, tissue plasminogen activator), renal function (glomerular filtration rate) and glucose homeostasis (blood glucose, homeostatic model assessment index) were not or to a minor extent associated with blood pressure variability. In an elderly population at risk of cardiovascular disease, inflammation (as evidenced by higher levels of interleukin-6) is associated with higher intra-individual variability in systolic, diastolic, and pulse pressure. © American Journal of Hypertension, Ltd 2014. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  14. Electrophysiological correlates of implicit valenced self-processing in high vs. low self-esteem individuals.

    Science.gov (United States)

    Grundy, John G; Benarroch, Miriam F F; Lebarr, A Nicole; Shedden, Judith M

    2015-01-01

    We provide the first high-temporal resolution account of the self-esteem implicit association test (IAT; Greenwald & Farnham, 2000) to highlight important similarities and differences between the cognitive processes corresponding to implicit valenced self-processing in high vs. low self-esteem individuals. We divided individuals into high and low self-esteem groups based on the Rosenberg self-esteem scale (Rosenberg, 1965) and administered the self-esteem IAT while recording electroencephalographic data. We show that the P2 captured group (high vs. low self-esteem) differences, the N250 and the late parietal positivity (LPP) captured differences corresponding to category pairing (self/positive vs. self/negative pairing), and the N1, P2, and P300-400 components captured interactions between self-esteem groups and whether the self was paired with positive or negative categories in the IAT. Overall, both high and low self-esteem groups were sensitive to the distinction between positive and negative information in relation to the self (me/negative generally displayed larger event-related potential amplitudes than me/positive), but for high self-esteem individuals, this difference was generally larger, earlier, and most pronounced over left-hemisphere electrodes. These electrophysiological differences may reflect differences in attentional resources devoted to teasing apart these two oppositely valenced associations. High self-esteem individuals appear to devote more automatic (early) attentional resources to strengthen the distinction between positively or negatively valenced information in relation to the self.

  15. Heritability of high sugar consumption through drinks and the genetic correlation with substance use.

    Science.gov (United States)

    Treur, Jorien L; Boomsma, Dorret I; Ligthart, Lannie; Willemsen, Gonneke; Vink, Jacqueline M

    2016-10-01

    High sugar consumption contributes to the rising prevalence of obesity. Sugar can have rewarding effects that are similar to, but less strong than, the effects of addictive substances. People who consume large amounts of sugar also tend to use more addictive substances, but it is unclear whether this is due to shared genetic or environmental risk factors. We examined whether there are genetic influences on the consumption of sugar-containing drinks and whether genetic factors can explain the association with substance use. The frequency of consumption of sugar-containing drinks (e.g., cola, soft drinks, and energy drinks) and addictive substances (nicotine, caffeine, alcohol, cannabis, and illicit drugs) was obtained for 8586 twins who were registered at the Netherlands Twin Register (women: 68.7%; mean ± SD age: 33.5 ± 15.3 y). Participants were categorized as high or low sugar consumers (>1 compared with ≤1 SD above daily consumption in grams) and as high or low substance users (≥2 compared with consumption, substance use, and their association were estimated. Genetic factors explained 48% of the variation in high sugar consumption, whereas unique environmental factors explained 52%. For high substance use, these values were 62% and 38%, respectively. There was a moderate phenotypic association between high sugar consumption and high substance use (r = 0.2), which was explained by genetic factors (59%) and unique environmental factors (41%). The positive association between high sugar consumption and high substance use was partly due to unique environmental factors (e.g., social situations). Genetic factors were also of influence, suggesting that neuronal circuits underlying the development of addiction and obesity are related. Further research is needed to identify genes that influence sugar consumption and those that overlap with substance use. © 2016 American Society for Nutrition.

  16. Gene expression correlation analysis predicts involvement of high- and low-confidence risk genes in different stages of prostate carcinogenesis.

    Science.gov (United States)

    Yano, Kojiro

    2010-12-01

    Whole genome association studies have identified many loci associated with the risk of prostate cancer (PC). However, very few of the genes associated with these loci have been related to specific processes of prostate carcinogenesis. Therefore I inferred biological functions associated with these risk genes using gene expression correlation analysis. PC risk genes reported in the literature were classified as having high (Plow (Phigh-confidence genes and other genes in the microarray dataset, whereas correlation between low-confidence genes and other genes in PC showed smaller decrease. Genes involved in developmental processes were significantly correlated with all risk gene categories. Ectoderm development genes, which may be related to squamous metaplasia, and genes enriched in fetal prostate stem cells (PSCs) showed strong association with the high-confidence genes. The association between the PSC genes and the low-confidence genes was weak, but genes related to neural system genes showed strong association with low-confidence genes. The high-confidence risk genes may be associated with an early stage of prostate carcinogenesis, possibly involving PSCs and squamous metaplasia. The low-confidence genes may be involved in a later stage of carcinogenesis. © 2010 Wiley-Liss, Inc.

  17. Correlation of PUV and SUV in the extremities while using PEM as a high-resolution positron emission scanner

    Energy Technology Data Exchange (ETDEWEB)

    Rahim, Sania [The University of Texas MD Anderson Cancer Center, Division of Diagnostic Imaging, Houston, TX (United States); MD Anderson Cancer Center, Houston, TX (United States); Mawlawi, Osama; Taylor, Shree; Millican, Richelle; Swanston, Nancy M.; Rohren, Eric M. [The University of Texas MD Anderson Cancer Center, Division of Diagnostic Imaging, Houston, TX (United States); Fox, Patricia [The University of Texas MD Anderson Cancer Center, Division of Biostatistics, Houston, TX (United States); Brown, J.E. [Yale University Hospital, Department of Radiology, New Haven, CT (United States)

    2014-04-15

    Owing to its unique configuration of two adjustable plate detectors positron emission mammography, or PEM, could theoretically also function as a high-resolution positron emission scanner for the extremities or neck. PEM quantitates its activity via a ''PEM uptake value,'' or PUV, and although its relationship to the standardized uptake value, or SUV, has been demonstrated in the breasts, to our knowledge there are no studies validating PUV in other sites such as the extremities. This was a retrospective chart review of two separate protocols of a total of 15 patients. The patients all had hypermetabolic lesions in the extremities or neck on imaging with PET/CT and were sent after their PET/CT to PEM for further imaging. Owing to the sequential nature of these examinations no additional radiotracer was administered. Spearman's rank order correlation was calculated between the PUVmax obtained from PEM images, and the SUVmax for all. Spearman's rank order correlation for all sites was 0.42, which is not significantly different from 0 (p = 0.13). When neck lesions were excluded from the group, there was a strong and statistically significant correlation between PUVmax and SUVmax, with Spearman's rank correlation of 0.73, and significantly different from 0 (p = 0.0068). The correlation of PUV and SUV in the extremities indicates the potential use of PEM as a semiquantitative, high-resolution positron emission scanner and warrants further investigation, especially in the realms of disease processes that often present in the extremities, such as melanoma, osteomyelitis, and arthritis, as well as playing a role in the imaging of patients with metallic hardware post-limb salvage surgery. (orig.)

  18. Changes in gut microbiota in rats fed a high fat diet correlate with obesity-associated metabolic parameters.

    Directory of Open Access Journals (Sweden)

    Virginie Lecomte

    Full Text Available The gut microbiota is emerging as a new factor in the development of obesity. Many studies have described changes in microbiota composition in response to obesity and high fat diet (HFD at the phylum level. In this study we used 16s RNA high throughput sequencing on faecal samples from rats chronically fed HFD or control chow (n = 10 per group, 16 weeks to investigate changes in gut microbiota composition at the species level. 53.17% dissimilarity between groups was observed at the species level. Lactobacillus intestinalis dominated the microbiota in rats under the chow diet. However this species was considerably less abundant in rats fed HFD (P<0.0001, this being compensated by an increase in abundance of propionate/acetate producing species. To further understand the influence of these species on the development of the obese phenotype, we correlated their abundance with metabolic parameters associated with obesity. Of the taxa contributing the most to dissimilarity between groups, 10 presented significant correlations with at least one of the tested parameters, three of them correlated positively with all metabolic parameters: Phascolarctobacterium, Proteus mirabilis and Veillonellaceae, all propionate/acetate producers. Lactobacillus intestinalis was the only species whose abundance was negatively correlated with change in body weight and fat mass. This species decreased drastically in response to HFD, favouring propionate/acetate producing bacterial species whose abundance was strongly correlated with adiposity and deterioration of metabolic factors. Our observations suggest that these species may play a key role in the development of obesity in response to a HFD.

  19. Correlating hemodynamic magnetic resonance imaging with high-field intracranial vessel wall imaging in stroke.

    Science.gov (United States)

    Langdon, Weston; Donahue, Manus J; van der Kolk, Anja G; Rane, Swati; Strother, Megan K

    2014-06-01

    Vessel wall magnetic resonance imaging at ultra-high field (7 Tesla) can be used to visualize vascular lesions noninvasively and holds potential for improving stroke-risk assessment in patients with ischemic cerebrovascular disease. We present the first multi-modal comparison of such high-field vessel wall imaging with more conventional (i) 3 Tesla hemodynamic magnetic resonance imaging and (ii) digital subtraction angiography in a 69-year-old male with a left temporal ischemic infarct.

  20. Plasma Wind Tunnel Testing of Ultra High Temperature Ceramics: Experiments And Numerical Correlation

    OpenAIRE

    Di Maso, Andrea

    2009-01-01

    The thesis is focused on the aerothermodynamic and oxidation behaviour of ultra-high-temperature Ceramic (UHTC) for aerospace applications. UHTC are very high temperature resistant (>2000K) materials, with good chemical inertness and mechanical properties. These materials could be used for next generation aerospace and hypersonic vehicles. The arc jet plasma wind tunnel available at the Department of Aerospace Engineering of Naples (DIAS) is able to reproduce specific total enthalpies and sta...

  1. Waterpipe use among high school students in Ontario: Demographic and substance use correlates.

    Science.gov (United States)

    Hamilton, Hayley A; Ferrence, Roberta; Boak, Angela; O'Connor, Shawn; Mann, Robert E; Schwartz, Robert; Adlaf, Edward M

    2015-03-12

    To examine waterpipe use and its association with demographic factors, tobacco cigarette smoking, ever use of electronic cigarettes (e-cigarettes) and alcohol use among high school students. Data were derived from the 2013 Ontario Student Drug Use and Health Survey, a school-based survey of 7th to 12th grade students. This province-wide survey was based on a stratified two-stage cluster design. Analyses were based on a subsample of 2,873 high school students and included adjustments for the complex sample design. Overall, 12.5% of high school students (grades 9-12) had used a waterpipe in the previous year. Awareness of waterpipes was high - 68.4% of students reported that they were aware of waterpipes but had not used one in the past year; 19.1% had never heard of waterpipes or hookah. The percentage of high school students reporting waterpipe use in the past year was similar to reports of tobacco cigarette use (12.5% and 11% respectively). Waterpipe use was highly associated with past-year tobacco cigarette and regular alcohol use as well as ever use of e-cigarettes. In multivariate analyses, males and females had similar odds of waterpipe use, and non-White students and those in higher grades had greater odds of use after controlling for other substance use. These findings suggest that waterpipe use among high school students should be of some concern and suggest the need for policy measures to address potential risks associated with use.

  2. Correlation of low levels of nitrite and high levels of fetal hemoglobin in patients with sickle cell disease at baseline

    Directory of Open Access Journals (Sweden)

    Darcielle Bruna Dias Elias

    2012-01-01

    Full Text Available BACKGROUND: Sickle cell disease is a hemoglobinopathy characterized by hemolytic anemia, increased susceptibility to infections and recurrent vaso-occlusive crises that reduces the quality of life of sufferers. OBJECTIVE: To evaluate the correlation of the levels of lactate dehydrogenase, malonaldehyde and nitrite to fetal hemoglobin in patients with sickle cell disease not under treatment with hydroxyurea in outpatients at a university hospital in Fortaleza, Ceará, Brazil. METHODS: Forty-four patients diagnosed with sickle cell disease were enrolled at baseline. Diagnosis was confirmed by evaluating the beta globin gene using polymerase chain reaction-restriction fragment length polymorphism. The concentration of fetal hemoglobin was obtained by high-performance liquid chromatography. Serum levels of nitrite, malonaldehyde and lactate dehydrogenase were measured by biochemical methods. RESULTS: Significantly higher levels of lactate dehydrogenase, nitrite and malonaldehyde were observed in patients with sickle cell disease compared to a control group. The study of the correlation between fetal hemoglobin levels and these variables showed a negative correlation with nitrite levels. No correlation was found between fetal hemoglobin and malonaldehyde or lactate dehydrogenase. When the study population was stratified according to fetal hemoglobin levels, a decrease in the levels of nitrite was observed with higher levels of fetal hemoglobin (p-value = 0.0415. CONCLUSION: The results show that, similar to fetal hemoglobin levels, the concentration of nitrite can predict the clinical course of the disease, but should not be used alone as a modulator of prognosis in patients with sickle cell disease.

  3. Methylglyoxal-Mediated Stress Correlates with High Metabolic Activity and Promotes Tumor Growth in Colorectal Cancer

    Science.gov (United States)

    Chiavarina, Barbara; Nokin, Marie-Julie; Bellier, Justine; Durieux, Florence; Bletard, Noëlla; Sherer, Félicie; Lovinfosse, Pierre; Peulen, Olivier; Verset, Laurine; Dehon, Romain; Demetter, Pieter; Turtoi, Andrei; Uchida, Koji; Goldman, Serge; Hustinx, Roland; Delvenne, Philippe; Castronovo, Vincent; Bellahcène, Akeila

    2017-01-01

    Cancer cells generally rely on aerobic glycolysis as a major source of energy. Methylglyoxal (MG), a dicarbonyl compound that is produced as a side product during glycolysis, is highly reactive and induces the formation of advanced glycation end-products that are implicated in several pathologies including cancer. All mammalian cells have an enzymatic defense against MG composed by glyoxalases GLO1 and GLO2 that converts MG to d-lactate. Colorectal cancer (CRC) is one of the most frequently occurring cancers with high morbidity and mortality. In this study, we used immunohistochemistry to examine the level of MG protein adducts, in a series of 102 CRC human tumors divided into four clinical stages. We consistently detected a high level of MG adducts and low GLO1 activity in high stage tumors compared to low stage ones suggesting a pro-tumor role for dicarbonyl stress. Accordingly, GLO1 depletion in CRC cells promoted tumor growth in vivo that was efficiently reversed using carnosine, a potent MG scavenger. Our study represents the first demonstration that MG adducts accumulation is a consistent feature of high stage CRC tumors. Our data point to MG production and detoxification levels as an important molecular link between exacerbated glycolytic activity and CRC progression. PMID:28117708

  4. High Telomerase Activity Correlates with the Stabilities of Genome and DNA Ploidy in Renal Cell Carcinoma

    Directory of Open Access Journals (Sweden)

    Hideki Izumi

    2002-01-01

    Full Text Available Malignant tumors have telomerase activity, which is thought to play a critical role in tumor growth. However, the relation between telomerase activity and genomic DNA status in tumor cells is poorly understood. In the present study, we examined telomerase activity in 13 clear cell type renal cell carcinomas (CRCCs with similar clinicopathologic features by telomeric repeat amplification protocol assay (TRAP. Based on TRAP assay results, we divided the CRCCs into two groups: a high telomerase activity group and a low/no telomerase activity group. We then analyzed genomic aberration, DNA ploidy, and telomere status in these two groups by comparative genomic hybridization (CGH, laser scanning cytometry (LSC, and telomere-specific fluorescence in situ hybridization (T-FISH, respectively. CGH showed the high telomerase activity group to have fewer genomic changes than the low/no telomerase activity group, which had many genomic aberrations. Moreover, with LSC, DNA diploid cells were found more frequently in the high telomerase activity group than in the low/no telomerase activity group. In addition, T-FISH revealed strong telomere signal intensity in the high telomerase activity group compared with that of the low/no telomerase activity group. These results suggest that telomerase activity is linked to genomic DNA status and that high telomerase activity is associated with genomic stability, DNA ploidy, and telomere length in CRCC.

  5. Endotoxin levels correlate positively with a sedentary lifestyle and negatively with highly trained subjects

    Directory of Open Access Journals (Sweden)

    Oyama Lila M

    2010-08-01

    Full Text Available Abstract Introduction A sedentary lifestyle increases the risk of developing cardiovascular disease, obesity, and diabetes. This phenomenon is supported by recent studies suggesting a chronic, low-grade inflammation status. Endotoxin derived from gut flora may be key to the development of inflammation by stimulating the secretion of inflammatory factors. This study aimed to examine plasma inflammatory markers and endotoxin levels in individuals with a sedentary lifestyle and/or in highly trained subjects at rest. Methods: Fourteen male subjects (sedentary lifestyle n = 7; highly trained subjects n = 7 were recruited. Blood samples were collected after an overnight fast (~12 h. The plasmatic endotoxin, plasminogen activator inhibitor type-1 (PAI-1, monocyte chemotactic protein-1 (MCP1, ICAM/CD54, VCAM/CD106 and lipid profile levels were determined. Results Endotoxinemia was lower in the highly trained subject group relative to the sedentary subjects (p Conclusion These results indicate that a lifestyle associated with high-intensity and high-volume exercise induces favorable changes in chronic low-grade inflammation markers and may reduce the risk for diseases such as obesity, diabetes and cardiovascular diseases.

  6. High-resolution long-reach distributed Brillouin sensing based on combined time-domain and correlation-domain analysis.

    Science.gov (United States)

    Elooz, David; Antman, Yair; Levanon, Nadav; Zadok, Avi

    2014-03-24

    A new scheme for distributed Brillouin sensing of strain and temperature in optical fibers is proposed, analyzed and demonstrated experimentally. The technique combines between time-domain and correlation-domain analysis. Both Brillouin pump and signal waves are repeatedly co-modulated by a relatively short, high-rate phase sequence, which introduces Brillouin interactions in a large number of discrete correlation peaks. In addition, the pump wave is also modulated by a single amplitude pulse, which leads to a temporal separation between the generation of different peaks. The Brillouin amplification of the signal wave at individual peak locations is resolved in the time domain. The technique provides the high spatial resolution and long range of unambiguous measurement offered by correlation-domain Brillouin analysis, together with reduced acquisition time through the simultaneous interrogation of a large number of resolution points. In addition, perfect Golomb codes are used in the phase modulation of the two waves instead of random sequences, in order to reduce noise due to residual, off-peak Brillouin interactions. The principle of the method is supported by extensive numerical simulations. Using the proposed scheme, the Brillouin gain spectrum is mapped experimentally along a 400 m-long fiber under test with a spatial resolution of 2 cm, or 20,000 resolution points, with only 127 scans per choice of frequency offset between pump and signal. Compared with corresponding phase-coded, Brillouin correlation domain analysis schemes with equal range and resolution, the acquisition time is reduced by a factor of over 150. A 5 cm-long hot spot, located towards the output end of the pump wave, is properly identified in the measurements. The method represents a significant advance towards practical high-resolution and long range Brillouin sensing systems.

  7. Prevalence and Correlates of Leprosy in a High-Risk Community Setting in Sri Lanka.

    Science.gov (United States)

    Dabrera, Thushani Marie Elizabeth; Tillekeratne, L Gayani; Fernando, M S Nilanthi; Kasturiaratchi, S T Kaushlya; Østbye, Truls

    2016-10-01

    Leprosy is caused by the Mycobacterium leprae bacillus. Pockets of high endemicity remain in a number of countries including Sri Lanka, in spite of the fact that elimination has been achieved at the national level. In 2012, in a village in the Puttlam district, dermatologists reported an increase in individuals with leprosy. This village had been established in the 1990s for people displaced from Northern Sri Lanka during a civil war. A comprehensive household survey was conducted by district health officials from June to July 2012, and all household members present during the survey period were examined for leprosy lesions. Patients with suspected leprosy were referred to a dermatology clinic for clinical or pathological confirmation. The prevalence of leprosy was high (511 per 10 000 population). Household contact with another patient with leprosy increased the risk of leprosy (odds ratio = 6.69; P leprosy at bay in high-risk communities.

  8. A high PCT level correlates with disease severity in Plasmodium falciparum malaria in children.

    Science.gov (United States)

    Carannante, Novella; Rossi, Marco; Fraganza, Fiorentino; Coppola, Grazia; Chiesa, Daniela; Attanasio, Vittorio; Sbrana, Francesco; Corcione, Antonio; Tascini, Carlo

    2017-01-01

    Most clinicians in developed countries have limited experience in making clinical assessments of malaria disease severity and/or monitoring high-level parasitemia in febrile patients with imported malaria. Hyperparasitemia is a risk factor for severe P. falciparum malaria, and procalcitonin (PCT) has recently been related to the severity of malaria. In developed countries, where not all hospital have skilled personnel to count parasitemia, a rapid test might be useful for the prompt diagnosis of malaria but unfortunately these tests are not able to count the number of parasites. In this context, PCT might have a prognostic value for the assessment of severe malaria, especially in children with cerebral malaria. We describe two children with severe cerebral malaria, who were directly admitted to the ICU with a high level of PCT and extremely high (>25%) parasitemia. Our conclusion is that PCT may also be a measure of severity of P. falciparum malaria in children.

  9. Smoking-promoted oxidative DNA damage response is highly correlated to lung carcinogenesis.

    Science.gov (United States)

    Cao, Chao; Lai, Tianwen; Li, Miao; Zhou, Hongbin; Lv, Dan; Deng, Zaichun; Ying, Songmin; Chen, Zhihua; Li, Wen; Shen, Huahao

    2016-04-05

    Oxidative stress induced by tobacco smoking is one of the main causes of DNA damage and is known to be involved in various cancers. Smoking is the leading cause of lung cancer, while the role of cigarette smoke-induced oxidative DNA damage response during lung carcinogenesis is largely unknown. In this study, we investigated oxidative DNA damage response levels in smoking and nonsmoking patients with lung cancer, and evaluated the potential diagnostic value of 8-OHdG for lung cancer. We observed a higher level of 8-OHdG expression and secretion in airways of lung cancer patients than that of noncancer controls. 8-OHdG expression was associated with the TNM stages. Additionally, cigarette smoke-induced oxidative DNA damage response was observed in bronchial epithelial cells in vitro and in vivo. A statistical significance correlation was found between the levels of 8-OHdG and smoking index. With a cut-off value of 2.86 ng/ml, 8-OHdG showed a sensitivity and specificity of 70.0% and 73.7%, respectively, to identify a patient with lung cancer. These findings not only underscore the importance of smoking in oxidative DNA damage response of lung cancer patients, but also suggest 8-OHdG as a potential diagnostic biomarker for lung cancer.

  10. Thermo-mechanical toner transfer for high-quality digital image correlation speckle patterns

    Science.gov (United States)

    Mazzoleni, Paolo; Zappa, Emanuele; Matta, Fabio; Sutton, Michael A.

    2015-12-01

    The accuracy and spatial resolution of full-field deformation measurements performed through digital image correlation are greatly affected by the frequency content of the speckle pattern, which can be effectively controlled using particles with well-defined and consistent shape, size and spacing. This paper introduces a novel toner-transfer technique to impress a well-defined and repeatable speckle pattern on plane and curved surfaces of metallic and cement composite specimens. The speckle pattern is numerically designed, printed on paper using a standard laser printer, and transferred onto the measurement surface via a thermo-mechanical process. The tuning procedure to compensate for the difference between designed and toner-transferred actual speckle size is presented. Based on this evidence, the applicability of the technique is discussed with respect to surface material, dimensions and geometry. Proof of concept of the proposed toner-transfer technique is then demonstrated for the case of a quenched and partitioned welded steel plate subjected to uniaxial tensile loading, and for an aluminum plate exposed to temperatures up to 70% of the melting point of aluminum and past the melting point of typical printer toner powder.

  11. Devonian Frasnian-Famennian Transitional Milankovitch Cycles and High-Resolution Stratigraphic Correlation

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Four hierarchical cyclothems, superbundlesets, bundlesets,bundles and laminae, have been identified from the Devonian Frasnian-Famennian carbonate strata in Guangxi, South China. Their hierarchical structures, ratio relation ships and sequence in conodont zones are continuous and stable and can be traced across different facies zones and sedi mentary basins. Our data show that hierarchically organized superbundlesets, bundlesets, bundles and laminae correspond to the long eccentricity, eccentricity, obliquity or precession and sub-Milankovitch cycles respectively. Their periods were 400,000, 100,000, 33,333, 16,667 and 8,000-17,000 a, respectively. The ratios of long eccentricity to eccentricity, ec centricity to obliquity, and eccentricity to precession in the Devonian are 1:4, 1:3 and 1:6 respectively. Using these hier archical Milankovitch cyclothems, chronostratigraphical division and correlation can be realized at a resolution of 100 ka or 10 ka at the Frasnian-Famennian transition. The time intervals of the Upper rhenana Zone, linguiformis Zone, and the Lower, Middle and Upper triangularis Zone are 0.6, 0.8, 0.3, 0.3 and 0.3 Ma, respectively. Sea-level changes of the Frasnian-Famennian transition were not coherent and synchronous at the resolution of 100 ka or 10 ka in the basin-slope carbonate sequences of Guangxi, South China.

  12. Real-time data acquisition incorporating high-speed software correlator for single-molecule spectroscopy.

    Science.gov (United States)

    Yang, L-L; Lee, H-Y; Wang, M-K; Lin, X-Y; Hsu, K-H; Chang, Y-R; Fann, W; White, J D

    2009-06-01

    Single-molecule spectroscopy and detection are powerful techniques for the study of single fluorescent particles and their interaction with their environment. We present a low-cost system for simultaneous real-time acquisition, storage of inter-photon arrival times and the calculation and display of the fluorescence time trace, autocorrelation function and distribution of delays histogram for single-molecule experiments. From a hardware perspective, in addition to a multi-core computer, only a standard low-cost counting board is required as processing is software-based. Software is written in a parallel programming environment with time crucial operations coded in ANSI-C. Crucial to system performance is a simple and efficient real-time autocorrelation algorithm (acf) optimized for the count rates (approximately 10(4) cps) encountered in single-molecule experiments. The algorithm's time complexity is independent of temporal resolution, which is maintained at all time delays. The system and algorithm's performance was validated by duplicating the signal from the photon detector and sending it to both the ordinary counter board and a commercial correlator simultaneously. The data acquisition system's robustness under typical single-molecule experimental conditions was tested by observing the diffusion of Rhodamine 6G molecules in deionized water.

  13. Dissecting the high-z interstellar medium through intensity mapping cross-correlations

    CERN Document Server

    Serra, Paolo; Lagache, Guilaine

    2016-01-01

    We explore the detection, with upcoming spectroscopic surveys, of three-dimensional power spectra of emission line fluctuations produced in different phases of the Interstellar Medium (ISM) by ionized carbon, ionized nitrogen and neutral oxygen at redshift z>4. The emission line [CII] from ionized carbon at 157.7 micron, and multiple emission lines from carbon monoxide, are the main targets of planned ground-based surveys, and an important foreground for future space-based surveys like the Primordial Inflation Explorer (PIXIE). However, the oxygen [OI] (145.5 micron) line, and the nitrogen [NII] (121.9 micron and 205.2 micron) lines, might be detected in correlation with [CII] with reasonable signal-to-noise ratio (SNR). These lines are important coolants of both the neutral and the ionized medium, and probe multiple phases of the ISM. We compute predictions of the three-dimensional power spectra for two surveys designed to target the [CII] line, showing that they have the required sensitivity to detect cross...

  14. Correlation of findings in clinical and high resolution ultrasonography examinations of the painful shoulder

    Directory of Open Access Journals (Sweden)

    Raphael Micheroli

    2015-03-01

    Full Text Available Objective: High resolution ultrasonography is a non-painful and non-invasive imaging technique which is useful for the assessment of shoulder pain causes, as clinical examination often does not allow an exact diagnosis. The aim of this study was to compare the fi ndings of clinical examination and high resolution ultrasonography in patients presenting with painful shoulder. Methods: Non-interventional observational study of 100 adult patients suffering from unilateral shoulder pain. Exclusion criteria were shoulder fractures, prior shoulder joint surgery and shoulder injections in the past month. The physicians performing the most common clinical shoulder examinations were blinded to the results of the high resolution ultrasonography and vice versa. Results: In order to detect pathology of the m. supraspinatus tendon, the Hawkins and Kennedy impingement test showed the highest sensitivity (0.86 whereas the Jobe supraspinatus test showed the highest specifi city (0.55. To identify m. subscapularis tendon pathology the Gerber lift off test showed a sensitivity of 1, whereas the belly press test showed the higher specifi city (0.72. The infraspinatus test showed a high sensitivity (0.90 and specifi city (0.74. All AC tests (painful arc IIa, AC joint tendernessb, cross body adduction stress testc showed high specifi cities (a0.96, b0.99, c 0.96. Evaluating the long biceps tendon, the palm up test showed the highest sensitivity (0.47 and the Yergason test the highest specifi city (0.88. Conclusion: Knowledge of sensitivity and specifi city of various clinical tests is important for the interpretation of clinical examination test results. High resolution ultrasonography is needed in most cases to establish a clear diagnosis.

  15. Prediction and correlation of high-pressure gas solubility in polymers with simplified PC-SAFT

    DEFF Research Database (Denmark)

    von Solms, Nicolas; Michelsen, Michael Locht; Kontogeorgis, Georgios

    2005-01-01

    Using simplified PC-SAFT we have modeled gas solubilities at high temperatures and pressures for the gases methane and carbon dioxide in each of the three polymers high-density polyethylene (HDPE), nylon polyamide-11 (PA-11), and poly(vinylidene fluoride) (PVDF). In general the results...... are satisfactory, using in most cases a single, temperature-independent value of the binary interaction parameter. In the cases of methane in HDPE and PVDF, a temperature-dependent binary interaction parameter was required. New pure component polymer parameters for PA-11 and PVDF were obtained using a recently...

  16. Characterization of Impact Damage in Ultra-High Performance Concrete Using Spatially Correlated Nanoindentation/SEM/EDX

    Science.gov (United States)

    Moser, R. D.; Allison, P. G.; Chandler, M. Q.

    2013-12-01

    Little work has been done to study the fundamental material behaviors and failure mechanisms of cement-based materials including ordinary Portland cement concrete and ultra-high performance concretes (UHPCs) under high strain impact and penetration loads at lower length scales. These high strain rate loadings have many possible effects on UHPCs at the microscale and nanoscale, including alterations in the hydration state and bonding present in phases such as calcium silicate hydrate, in addition to fracture and debonding. In this work, the possible chemical and physical changes in UHPCs subjected to high strain rate impact and penetration loads were investigated using a novel technique wherein nanoindentation measurements were spatially correlated with images using scanning electron microscopy and chemical composition using energy dispersive x-ray microanalysis. Results indicate that impact degrades both the elastic modulus and indentation hardness of UHPCs, and in particular hydrated phases, with damage likely occurring due to microfracturing and debonding.

  17. Patterns and Correlates of Drug Use Among Urban High School Students

    Science.gov (United States)

    Mc Killip, Jack; And Others

    1973-01-01

    A drug-use survey was administered in a large metropolitan, middle class high school to test two hypotheses: a. drug users can be divided according to the types of drugs used (tobacco, alcohol, and marijuana vs. opiates, LSD, amphetamines, etc.); and, b. respondents' drug use is significantly related to their peers drug use. Both hypotheses were…

  18. Correlates of Attitudes Favorable to Racial Discrimination Among High School Students.

    Science.gov (United States)

    Chadwick, Bruce A.; And Others

    The behavior-specific attitude "tendency to discriminate" is distinguished from the general tendency toward negative stereotyping (prejudice). Thirteen independent variables are evaluated as predictors of this tendency. Subjects were students in a racially integrated high school in the Pacific Northwest. Among white students, the most significant…

  19. Heritability of high sugar consumption through drinks and the genetic correlation with substance use

    NARCIS (Netherlands)

    Treur, J.L.; Boomsma, D.I.; Ligthart, R.S.L.; Willemsen, G.; Vink, J.M.

    2016-01-01

    Background: High sugar consumption contributes to the rising prevalence of obesity. Sugar can have rewarding effects that are similar to, but less strong than, the effects of addictive substances. People who consume large amounts of sugar also tend to use more addictive substances, but it is unclear

  20. High Pressure X-ray Absorption Studies on Correlated-Electron Systems

    Energy Technology Data Exchange (ETDEWEB)

    Cornelius, Andrew L. [Univ. of Nevada, Las Vegas, NV (United States)

    2016-08-26

    This project used high pressure to alter the electron-electron and electron-lattice interactions in rare earth and actinide compounds. Knowledge of these properties is the starting points for a first-principles understanding of electronic and electronically related macroscopic properties. The research focused on a systematic study of x-ray absorption measurements on rare earth and actinide compounds.

  1. Cytohistological correlation of endocervical gland involvement with high-grade squamous intraepithelial lesions

    Directory of Open Access Journals (Sweden)

    G Kir

    2012-01-01

    Conclusion: Diagnosis of HSIL-EGI may be possible on Pap smears with a high positive predictive value and specificity but low sensitivity, possibly due to cytological sampling limitations. To clarify the results of the present study, more extensive studies with a particular emphasis on the sampling of the endocervical glandular area for cytological evaluation of the cervix are needed.

  2. Heritability of high sugar consumption through drinks and the genetic correlation with substance use

    NARCIS (Netherlands)

    Treur, J.L.; Boomsma, D.I.; Ligthart, R.S.L.; Willemsen, G.; Vink, J.M.

    2016-01-01

    Background: High sugar consumption contributes to the rising prevalence of obesity. Sugar can have rewarding effects that are similar to, but less strong than, the effects of addictive substances. People who consume large amounts of sugar also tend to use more addictive substances, but it is unclear

  3. Cognitive Correlates of Performance in Algorithms in a Computer Science Course for High School

    Science.gov (United States)

    Avancena, Aimee Theresa; Nishihara, Akinori

    2014-01-01

    Computer science for high school faces many challenging issues. One of these is whether the students possess the appropriate cognitive ability for learning the fundamentals of computer science. Online tests were created based on known cognitive factors and fundamental algorithms and were implemented among the second grade students in the…

  4. Neural correlates of heterotopic facilitation induced after high frequency electrical stimulation of nociceptive pathways

    NARCIS (Netherlands)

    Broeke, E.N. van den; Heck, C.H. van; Rijn, C.M. van; Wilder-Smith, O.H.G.

    2011-01-01

    Background High frequency electrical stimulation (HFS) of primary nociceptive afferents in humans induce a heightened sensitivity in the surrounding non-stimulated skin area. Several studies suggest that this heterotopic effect is the result of central (spinal) plasticity. The aim of this study is t

  5. HIGH-SPIN OCTUPOLE CORRELATIONS IN THE N=86, ND-146 AND SM-148 NUCLEI

    NARCIS (Netherlands)

    LIEDER, RM; BACELAR, JC; SINGH, PP; ALBER, D; BALABANSKI, D; GAST, W; GRAWE, H; HEBBINGHAUS, G; JONGMAN, [No Value; MOREK, T; NOORMAN, RF; RZACAURBAN, T; SCHNARE, H; THOMS, M; ZELL, O; NAZAREWICZ, W

    1991-01-01

    High-spin states in Nd-146 and Sm-148 have been populated using the C-13 + Xe-136 and Ne-22 + Te-130 compound nucleus reactions. Alternating parity bands built on the ground state are observed to spin I = (19) and I = (27) in Nd-146 and Sm-148 respectively. Analysis of the data done in terms of the

  6. High serum coenzyme Q10, positively correlated with age, selenium and cholesterol in Inuit of Greenland

    DEFF Research Database (Denmark)

    Pedersen, Henning Sloth; Mortensen, S.A.; Rhode, M.

    1999-01-01

    .001) compared to a Danish population. In a linear multiple regression model the S-CoQ10 level is significantly positively associated with age and S-selenium in males, and S-total cholesterol in females. The high level of CoQ10 in Greenlanders probably reflects diet, since no bioaccumulation takes place...

  7. Social Media Use, Loneliness, and Academic Achievement: A Correlational Study with Urban High School Students

    Science.gov (United States)

    Neto, Roque; Golz, Nancy; Polega, Meaghan

    2015-01-01

    This study explored the association between social media use, loneliness, and academic achievement in high school students and identified the demographic characteristics associated with these three elements. This study also aimed to identify the percentage of variance in loneliness accounted for by social media use and GPA. Participants were 345…

  8. Cognitive Correlates of Performance in Algorithms in a Computer Science Course for High School

    Science.gov (United States)

    Avancena, Aimee Theresa; Nishihara, Akinori

    2014-01-01

    Computer science for high school faces many challenging issues. One of these is whether the students possess the appropriate cognitive ability for learning the fundamentals of computer science. Online tests were created based on known cognitive factors and fundamental algorithms and were implemented among the second grade students in the…

  9. Patterns and Correlates of Drug Use Among Urban High School Students

    Science.gov (United States)

    Mc Killip, Jack; And Others

    1973-01-01

    A drug-use survey was administered in a large metropolitan, middle class high school to test two hypotheses: a. drug users can be divided according to the types of drugs used (tobacco, alcohol, and marijuana vs. opiates, LSD, amphetamines, etc.); and, b. respondents' drug use is significantly related to their peers drug use. Both hypotheses were…

  10. Towards high velocity deformation characterisation of metals and composites using Digital Image Correlation

    DEFF Research Database (Denmark)

    Eriksen, Rasmus Normann Wilken; Berggreen, Christian; Boyd, S.W

    2010-01-01

    testing in the strain rate regime from 1 – 500 ε/s. The range is much lower than that experienced under ballistic, shock or impact loads, nevertheless it is a useful starting point for the application of optical techniques. The present study examines the possibility of using high speed cameras to capture...

  11. Asbestosis and other pulmonary fibrosis in asbestos-exposed workers: high-resolution CT features with pathological correlations

    Energy Technology Data Exchange (ETDEWEB)

    Arakawa, Hiroaki [Dokkyo Medical University, Department of Radiology, Mibu, Tochigi (Japan); Kishimoto, Takumi [Okayama Rosai Hospital, Asbestos Research Center, Okayama (Japan); Ashizawa, Kazuto [Nagasaki University Graduate School of Biomedical Sciences, Department of Clinical Oncology, Nagasaki (Japan); Kato, Katsuya [Kawasaki Medical School, Department of Diagnostic Radiology 2, Okayama (Japan); Okamoto, Kenzo [Hokkaido Chuo Hospital, Department of Pathology, Iwamizawa, Hokkaido (Japan); Honma, Koichi [Dokkyo Medical University, Department of Pathology, Mibu, Tochigi (Japan); Hayashi, Seiji [National Hospital Organization Kinki-Chuo Chest Medical Center, Osaka (Japan); Akira, Masanori [National Hospital Organization Kinki-Chuo Chest Medical Center, Department of Radiology, Osaka (Japan)

    2016-05-15

    The purpose was to identify distinguishing CT features of pathologically diagnosed asbestosis, and correlate diagnostic confidence with asbestos body burden. Thirty-three workers (mean age at CT: 73 years) with clinical diagnoses of asbestosis, who were autopsied (n = 30) or underwent lobectomy (n = 3), were collected. Two radiologists independently scored high-resolution CT images for various CT findings and the likelihood of asbestosis was scored. Two pathologists reviewed the pathology specimens and scored the confidence of their diagnoses. Asbestos body count was correlated with CT and pathology scores. Pathologically, 15 cases were diagnosed as asbestosis and 18 cases with various lung fibroses other than asbestosis. On CT, only the score of the subpleural curvilinear lines was significantly higher in asbestosis (p = 0.03). Accuracy of CT diagnosis of asbestosis with a high confidence ranged from 0.73 to 0.79. Asbestos body count positively correlated with CT likelihood of asbestosis (r = 0.503, p = 0.003), and with the confidence level of pathological diagnosis (r = 0.637, p < 0.001). Subpleural curvilinear lines were the only clue for the diagnosis of asbestosis. However, this was complicated by other lung fibrosis, especially at low asbestos body burden. (orig.)

  12. CORRELATIONS BETWEEN BLOOD PRESSURE AND BODY WEIGHT, SERUM LEPTIN IN HIGH CALORIE DIET-INDUCED OBESE RATS

    Institute of Scientific and Technical Information of China (English)

    Hu Zhi; Ma Aiqun; Yang Chun; Tian Hongyan

    2006-01-01

    Objective To examine the change of body weight (BW) and blood pressure (BP) in obese rats, clarify relationships between BP and BW and other factors. Methods Male Spraque-Dawley rats were fed either with normal diet (ND) or high calorie diet (HC) for 20 weeks. BW and BP of tail artery were observed biweekly and tetraweekly respectively; serum leptin and fasting insulin (FINS) were detected by enzyme-linked immunoadsordent assay (ELISA) and radioimmunoassay (RIA) respectively. Fasting plasma glucose (FPG) and free fatty acid(FFA) were measured by conventional means. Results BW, abdominal fat weight (AFW), ratio of abdominal fat weight to body weight (RF/W), systolic blood pressure (SBP), diastolic blood pressure (DBP), serum levels of leptin and FINS, FPG, FFA increased in the HD group after 20 weeks diet intervention (P<0.05 or P<0.01). SBP was strongly correlated with BW, leptin, FINS and FFA (P<0.05), DBP was correlated with FFA (r=0.47, P<0.05). In addition, leptin was positively correlated with BW, AFW, RF/W, FINS and FFA (P<0.05 or P<0.01). Conclusion In this study of high calorie-diet induced rats, the gain of BW is accompanied by increased BP. The obese rats have hyperleptinemia, hyperinsulinemia, hyperglycemia and dyslipidemia which may have important effects on the development of obesity-related hypertension. RF/W is the key factor in which affect serum leptin level.

  13. Correlative 3D imaging: CLSM and FIB-SEM tomography using high-pressure frozen, freeze-substituted biological samples.

    Science.gov (United States)

    Lucas, Miriam S; Guenthert, Maja; Gasser, Philippe; Lucas, Falk; Wepf, Roger

    2014-01-01

    Correlative light and electron microscopy aims at combining data from different imaging modalities, ideally from the same area of the one sample, in order to achieve a more holistic view of the hierarchical structural organization of cells and tissues. Modern 3D imaging techniques opened up new possibilities to expand morphological studies into the third dimension at the nanometer scale. Here we present an approach to correlate 3D light microscopy data with volume data from focused ion beam-scanning electron microscopy. An adapted sample preparation method based on high-pressure freezing for structure preservation, followed by freeze-substitution for multimodal en bloc imaging, is described. It is based on including fluorescent labeling during freeze-substitution, which enables histological context description of the structure of interest by confocal laser scanning microscopy prior to high-resolution electron microscopy. This information can be employed to relocate the respective structure in the electron microscope. This approach is most suitable for targeted small 3D volume correlation and has the potential to extract statistically relevant data of structural details for systems biology.

  14. SWARM: A Compact High Resolution Correlator and Wideband VLBI Phased Array Upgrade for SMA

    Science.gov (United States)

    Weintroub, Jonathan

    2014-06-01

    A new digital back end (DBE) is being commissioned on Mauna Kea. The “SMA Wideband Astronomical ROACH2 Machine”, or SWARM, processes a 4 GHz usable band in single polarization mode and is flexibly reconfigurable for 2 GHz full Stokes dual polarization. The hardware is based on the open source Reconfigurable Open Architecture Computing Hardware 2 (ROACH2) platform from the Collaboration for Astronomy Signal Processing and Electronics Research (CASPER). A 5 GSps quad-core analog-to-digital converter board uses a commercial chip from e2v installed on a CASPER-standard printed circuit board designed by Homin Jiang’s group at ASIAA. Two ADC channels are provided per ROACH2, each sampling a 2.3 GHz Nyquist band generated by a custom wideband block downconverter (BDC). The ROACH2 logic includes 16k-channel Polyphase Filterbank (F-engine) per input followed by a 10 GbE switch based corner-turn which feeds into correlator-accumulator logic (X-engines) co-located with the F-engines. This arrangement makes very effective use of a small amount of digital hardware (just 8 ROACH2s in 1U rack mount enclosures). The primary challenge now is to meet timing at full speed for a large and very complex FPGA bit code. Design of the VLBI phased sum and recorder interface logic is also in process. Our poster will describe the instrument design, with the focus on the particular challenges of ultra wideband signal processing. Early connected commissioning and science verification data will be presented.

  15. Neurophysiologic Correlates of Ketamine Sedation and Anesthesia: A High-density Electroencephalography Study in Healthy Volunteers.

    Science.gov (United States)

    Vlisides, Phillip E; Bel-Bahar, Tarik; Lee, UnCheol; Li, Duan; Kim, Hyoungkyu; Janke, Ellen; Tarnal, Vijay; Pichurko, Adrian B; McKinney, Amy M; Kunkler, Bryan S; Picton, Paul; Mashour, George A

    2017-07-01

    Previous studies have demonstrated inconsistent neurophysiologic effects of ketamine, although discrepant findings might relate to differences in doses studied, brain regions analyzed, coadministration of other anesthetic medications, and resolution of the electroencephalograph. The objective of this study was to characterize the dose-dependent effects of ketamine on cortical oscillations and functional connectivity. Ten healthy human volunteers were recruited for study participation. The data were recorded using a 128-channel electroencephalograph during baseline consciousness, subanesthetic dosing (0.5 mg/kg over 40 min), anesthetic dosing (1.5 mg/kg bolus), and recovery. No other sedative or anesthetic medications were administered. Spectrograms, topomaps, and functional connectivity (weighted and directed phase lag index) were computed and analyzed. Frontal theta bandwidth power increased most dramatically during ketamine anesthesia (mean power ± SD, 4.25 ± 1.90 dB) compared to the baseline (0.64 ± 0.28 dB), subanesthetic (0.60 ± 0.30 dB), and recovery (0.68 ± 0.41 dB) states; P ketamine anesthesia. Weighted phase lag index demonstrated theta phase locking within anterior regions (0.2349 ± 0.1170, P ketamine anesthesia. Alpha power gradually decreased with subanesthetic ketamine, and anterior-to-posterior directed connectivity was maximally reduced (0.0282 ± 0.0772) during ketamine anesthesia compared to all other states (P Ketamine anesthesia correlates most clearly with distinct changes in the theta bandwidth, including increased power and functional connectivity. Anterior-to-posterior connectivity in the alpha bandwidth becomes maximally depressed with anesthetic ketamine administration, suggesting a dose-dependent effect.

  16. The Correlation Between Metacognition Level with Self-Efficacy of Biology Education College Students

    Science.gov (United States)

    Ridlo, S.; Lutfiya, F.

    2017-04-01

    Self-efficacy is a strong predictor of academic achievement. Self-efficacy refers to the ability of college students to achieve the desired results. The metacognition level can influence college student’s self-efficacy. This study aims to identify college student’s metacognition level and self-efficacy, as well as determine the relationship between self-efficacy and metacognition level for college students of Biology Education 2013, Semarang State University. The ex-post facto quantitative research was conducted on 99 students Academic Year 2015/2016. Saturation sampling technique determined samples. E-D scale collected data for self-efficacy identification. Data for assess the metacognition level collected by Metacognitive Awareness Inventory. Data were analysed quantitatively by Pearson correlation and linear regression. Most college students have the high level of metacognition and average self-efficacy. Pearson correlation coefficient result was 0.367. This result showed that metacognition level and self-efficacy has a weak relationship. Based on linear regression test, self-efficacy influenced by metacognition level up to 13.5%. The results of the study showed that positive and significant relationships exist between metacognition level and self-efficacy. Therefore, if the metacognition level is high, then self-efficacy will also be high (appropriate).

  17. The rate of nonallelic homologous recombination in males is highly variable, correlated between monozygotic twins and independent of age.

    Directory of Open Access Journals (Sweden)

    Jacqueline A L MacArthur

    2014-03-01

    Full Text Available Nonallelic homologous recombination (NAHR between highly similar duplicated sequences generates chromosomal deletions, duplications and inversions, which can cause diverse genetic disorders. Little is known about interindividual variation in NAHR rates and the factors that influence this. We estimated the rate of deletion at the CMT1A-REP NAHR hotspot in sperm DNA from 34 male donors, including 16 monozygotic (MZ co-twins (8 twin pairs aged 24 to 67 years old. The average NAHR rate was 3.5 × 10(-5 with a seven-fold variation across individuals. Despite good statistical power to detect even a subtle correlation, we observed no relationship between age of unrelated individuals and the rate of NAHR in their sperm, likely reflecting the meiotic-specific origin of these events. We then estimated the heritability of deletion rate by calculating the intraclass correlation (ICC within MZ co-twins, revealing a significant correlation between MZ co-twins (ICC = 0.784, p = 0.0039, with MZ co-twins being significantly more correlated than unrelated pairs. We showed that this heritability cannot be explained by variation in PRDM9, a known regulator of NAHR, or variation within the NAHR hotspot itself. We also did not detect any correlation between Body Mass Index (BMI, smoking status or alcohol intake and rate of NAHR. Our results suggest that other, as yet unidentified, genetic or environmental factors play a significant role in the regulation of NAHR and are responsible for the extensive variation in the population for the probability of fathering a child with a genomic disorder resulting from a pathogenic deletion.

  18. High precision Cross-correlated imaging in Few-mode fibers

    DEFF Research Database (Denmark)

    Muliar, Olena; Usuga Castaneda, Mario A.; Kristensen, Torben

    2017-01-01

    ) in a few-mode fiber (FMF) are used as multiple spatial communication channels, comes in this context as a viable approach to enable the optimization of high-capacity links. From this perspective, it becomes highly necessary to possess a diagnostic tool for the precise modal characterization of FMFs. Among...... us to distinguishing differential time delays between HOMs in the picosecond timescale. Broad wavelength scanning in combination with spectral shaping, allows us to estimate the modal behavior of FMF without prior knowledge of the fiber parameters. We performed our demonstration at wavelengths from...... 850nm to 1100nm which can be easily extended to other wavelengths of interest just by replacing components with the appropriate coating. The method presented here aims to serve as flexible diagnostic tool that can be implemented in MDM systems for judicious evaluation of modal dispersion in FMFs...

  19. Correlation of high energy muons with primary composition in extensive air shower

    Science.gov (United States)

    Chou, C.; Higashi, S.; Hiraoka, N.; Ozaki, S.; Sato, T.; Suwada, T.; Takahasi, T.; Umeda, H.

    1985-01-01

    An experimental investigation of high energy muons above 200 GeV in extensive air showers has been made for studying high energy interaction and primary composition of cosmic rays of energies in the range 10 to the 14th power approx. 10 to the 15th power eV. The muon energies are estimated from the burst sizes initiated by the muons in the rock, which are measured by four layers of proportional counters, each of area 5 x 2.6 sq m, placed at 30 m.w.e. deep, Funasaka tunnel vertically below the air shower array. These results are compared with Monte Carlo simulations based on the scaling model and the fireball model for two primary compositions, all proton and mixed.

  20. Correlates of Marijuana Drugged Driving and Openness to Driving While High: Evidence from Colorado and Washington

    Science.gov (United States)

    Davis, Kevin C.; Allen, Jane; Duke, Jennifer; Nonnemaker, James; Bradfield, Brian; Farrelly, Matthew C.; Shafer, Paul; Novak, Scott

    2016-01-01

    Aims A potential unintended consequence of legalizing recreational marijuana is increased marijuana-related driving impairment. Some states where recreational marijuana is legal have begun implementing interventions to mitigate driving under the influence (DUI) of marijuana, including media campaigns to increase knowledge about DUI laws. However, little is known about the associations between knowledge of DUI laws and marijuana DUI behavior. In this study, we provide new data from a survey of marijuana users in Colorado and Washington to examine associations between marijuana drugged driving and two potential behavioral precursors of marijuana DUI. We also explore other factors that may influence marijuana DUI. Methods Data are from an online survey of marijuana users in Colorado and Washington. Respondents who reported any marijuana use in the past 30 days (n = 865) served as the analytic sample. We examined prevalence of two behavioral outcomes: (1) any driving of a motor vehicle while high in the past year and (2) driving a motor vehicle within 1 hour of using marijuana 5 or more times in the past month. Additional outcomes measuring willingness to drive while high were also assessed. Logistic regressions were used to estimate each outcome as a function of two multi-item scales measuring knowledge of the legal consequences of driving high and perceptions that driving while high is not safe. Additional covariates for potential confounders were included in each model. Results Prevalence of past-year driving while under the influence of marijuana was 43.6% among respondents. The prevalence of driving within 1 hour of using marijuana at least 5 times in the past month was 23.9%. Increased perception that driving high is unsafe was associated with lower odds of past-year marijuana DUI (OR = 0.31, P marijuana (OR = 0.26, P marijuana DUI laws was also associated with lower odds of each of these outcomes (OR = 0.63, P marijuana DUI were greater in magnitude for safety

  1. Correlates of Marijuana Drugged Driving and Openness to Driving While High: Evidence from Colorado and Washington.

    Directory of Open Access Journals (Sweden)

    Kevin C Davis

    Full Text Available A potential unintended consequence of legalizing recreational marijuana is increased marijuana-related driving impairment. Some states where recreational marijuana is legal have begun implementing interventions to mitigate driving under the influence (DUI of marijuana, including media campaigns to increase knowledge about DUI laws. However, little is known about the associations between knowledge of DUI laws and marijuana DUI behavior. In this study, we provide new data from a survey of marijuana users in Colorado and Washington to examine associations between marijuana drugged driving and two potential behavioral precursors of marijuana DUI. We also explore other factors that may influence marijuana DUI.Data are from an online survey of marijuana users in Colorado and Washington. Respondents who reported any marijuana use in the past 30 days (n = 865 served as the analytic sample. We examined prevalence of two behavioral outcomes: (1 any driving of a motor vehicle while high in the past year and (2 driving a motor vehicle within 1 hour of using marijuana 5 or more times in the past month. Additional outcomes measuring willingness to drive while high were also assessed. Logistic regressions were used to estimate each outcome as a function of two multi-item scales measuring knowledge of the legal consequences of driving high and perceptions that driving while high is not safe. Additional covariates for potential confounders were included in each model.Prevalence of past-year driving while under the influence of marijuana was 43.6% among respondents. The prevalence of driving within 1 hour of using marijuana at least 5 times in the past month was 23.9%. Increased perception that driving high is unsafe was associated with lower odds of past-year marijuana DUI (OR = 0.31, P < 0.01 and lower past-month odds of driving 5 or more times within 1 hour of using marijuana (OR = 0.26, P < 0.01. Increased knowledge of marijuana DUI laws was also associated

  2. Imaging actinic keratosis by high-definition optical coherence tomography. Histomorphologic correlation

    DEFF Research Database (Denmark)

    Boone, Marc A L M; Norrenberg, Sarah; Jemec, Gregor B E;

    2013-01-01

    transversal and axial directions, enable to visualize individual cells up to a depth of around 570 μm filling the imaging gap between conventional optical coherence tomography and reflectance confocal microscopy. We sought to determine the feasibility of detecting and grading of actinic keratosis...... by this technique using criteria defined for reflectance confocal microscopy compared to histology. In this pilot study, skin lesions of 17 patients with a histologically proven actinic keratosis were imaged by high-definition optical coherence tomography just before excision and images analysed qualitatively...... of photodamage. Using features already suggested by reflectance confocal microscopy, the study implies that high-definition optical coherence tomography facilitates in vivo diagnosis of actinic keratosis and allows the grading of different actinic keratosis lesions for increased clinical utility....

  3. Double ionization of helium by highly-charged-ion impact analyzed within the frozen-correlation approximation

    Energy Technology Data Exchange (ETDEWEB)

    Ciappina, M. F.; Kirchner, T.; Schulz, M. [ICFO-Institut de Ciences Fotoniques, 08860 Castelldefels (Barcelona) (Spain); Department of Physics and Astronomy, York University, 4700 Keele Street, Toronto, Ontario, M3J 1P3 (Canada); Department of Physics and LAMOR, Missouri University of Science and Technology, Rolla, MO 65409 (United States)

    2011-09-15

    We apply the frozen-correlation approximation (FCA) to analyze double ionization of helium by energetic highly charged ions. In this model the double ionization amplitude is represented in terms of single ionization amplitudes, which we evaluate within the continuum distorted wave-eikonal initial state (CDW-EIS) approach. Correlation effects are incorporated in the initial and final states, but are neglected during the time the collision process takes place. We implement the FCA using the Monte Carlo event generator technique, which allows us to generate theoretical event files and to compare theory and experiment using the same analysis tools. The comparison with previous theoretical results and with experimental data demonstrates, on the one hand, the validity of our earlier simple models to account for higher-order mechanisms, and, on the other hand, the robustness of the FCA.

  4. Azimuthal correlations of high-p{sub T} photons and hadrons in Au+Au collisions at STAR

    Energy Technology Data Exchange (ETDEWEB)

    Dietel, T.

    2006-07-01

    The STAR experiment observed a modification of the azimuthal correlations between a trigger particle and associated particles in central Au+Au collisions, where trigger particles with 4 GeVcorrelations between regions of high energy deposition in the electro-magnetic calorimeter as trigger- and charged tracks as associated particles. The data sample had been enriched by online event selection, allowing for the selection of trigger particles with a transverse energy of more than 10 GeV and associated particles with more than 2, 3 or 4 GeV. The trigger particles are a mixture of photon pairs from the decays of neutral pions and single photons, mainly from photon-jet events, with small contributions from other hadron decays and fragmentation photons. (orig.)

  5. Azimuthal correlations of high-p{sub T} photons and hadrons in Au+Au collisions at STAR

    Energy Technology Data Exchange (ETDEWEB)

    Dietel, T.

    2006-07-01

    The STAR experiment observed a modification of the azimuthal correlations between a trigger particle and associated particles in central Au+Au collisions, where trigger particles with 4 GeVcorrelations between regions of high energy deposition in the electro-magnetic calorimeter as trigger- and charged tracks as associated particles. The data sample had been enriched by online event selection, allowing for the selection of trigger particles with a transverse energy of more than 10 GeV and associated particles with more than 2, 3 or 4 GeV. The trigger particles are a mixture of photon pairs from the decays of neutral pions and single photons, mainly from photon-jet events, with small contributions from other hadron decays and fragmentation photons. (orig.)

  6. Simple Cellular Model of Long-Range Multiplicity and $p_t$ Correlations in High-Energy Nuclear Collisions

    CERN Document Server

    Vechernin, V V

    2003-01-01

    A simple cellular model for the description of the long-range multiplicity and $p_t$ correlations in high-energy nuclear collisions originating from the string fusion model is proposed. Three versions of the model: without fusion, with local and with global string fusion are formulated. A Gauss approximation which enables explicit analytical calculations of the correlation functions in some asymptotic cases in the framework of the model is developed. The assumptions of the model and the validity of a Gauss approximation are checked up in the simplest (no fusion) case when the explicit solution of the model can be found. The role of a size of cells is analysed. The modification of the results in the case of non-Poissonian distributions is also discussed.

  7. Correlation of critical temperature with the vibrational spectra of high-temperature superconducters

    Energy Technology Data Exchange (ETDEWEB)

    Bush, A.A.; Dubenko, I.S.; Limonov, M.F.; Markov, IU.F.; Panfilov, A.G. (Moskovskii Institut Radiotekhniki, Elektroniki i Avtomatiki, Moscow (USSR) Fiziko-Tekhnicheskii Institut, Moscow (USSR))

    1989-09-01

    An empirical relation between an increase in Tc and an increase in the frequencies of the vibrational spectra of different high-temperature superconducters of perovskite type is established. Taking this relation into account, a new system (Y{sub 1-x}Sc{sub x})(Ba{sub 1-y}Sr{sub y})2 Cu{sub 3}O(delta) is proposed, in which an increase in Tc is observed at intermediate concentrations. 13 refs.

  8. High Mobility Group Box Protein-1 Correlates with Renal Function in Chronic Kidney Disease (CKD)

    OpenAIRE

    Bruchfeld, Annette; Qureshi, Abdul Rashid; Lindholm, Bengt; Barany, Peter; Yang, Lihong; Stenvinkel, Peter; Tracey, Kevin J.

    2007-01-01

    Chronic kidney disease (CKD) is associated with inflammation and malnutrition and carries a markedly increased risk of cardiovascular disease (CVD). High Mobility Group Box Protein-1 (HMGB-1) is a 30-kDa nuclear and cytosolic protein known as a transcription and growth factor, recently identified as a proinflammatory mediator of tissue injury. Recent data implicates HMGB-1 in endotoxin lethality, rheumatoid arthritis, and atherosclerosis. The aim of this post-hoc, cross-sectional study was to...

  9. Correlation of normal and superconducting properties and unified approach to the description of high Tc oxides

    Science.gov (United States)

    Kresin, V. Z.; Wolf, S. A.

    1991-01-01

    We present a unified approach based on the Fermi liquid picture which allows us to describe the normal as well as the superconducting properties of the doped cuprates. The theory that is presented is for the doped compounds which are metallic. One can distinguish two interrelated, but nevertheless, different directions in the physics of high T(sub c): one involving the problem of carrier doping and the transition to the metallic state, and the second being the description of the metallic state. It is important that this metallic phase undergoes the transition into the superconducting state; as a result, our analysis is directly related to the origin of high T(sub c). We are using a quasi-2D Fermi liquid model to estimate the fundamental parameters of these very interesting materials. We find that this description is able to describe these materials and also that phonons and plasmons play a major role in the mechanism of high T(sub c).

  10. Lateral flow immunoassay for diagnosis of Trypanosoma cruzi infection with high correlation to the radioimmunoprecipitation assay.

    Science.gov (United States)

    Houghton, Raymond L; Stevens, Yvonne Y; Hjerrild, Kathryn; Guderian, Jeff; Okamoto, Masahiko; Kabir, Mazbahul; Reed, Steven G; Leiby, David A; Morrow, W John W; Lorca, Myriam; Raychaudhuri, Syamal

    2009-04-01

    The incidence of blood donors seropositive for Trypanosoma cruzi in North America has increased with population migration and more rigorous surveillance. The United States, considered nonendemic for T. cruzi, could therefore be at risk to exposure to parasite transmission through blood or organ donations. Current tests show variable reactivity, especially with Central American sera. Here we describe the development of a lateral flow immunoassay for the rapid detection of T. cruzi infection that has a strong correlation to the radioimmunoprecipitation assay (RIPA) "gold standard" in the United States. Such a test could have utility in small blood banks for prescreening donors, as well as in cardiac transplantation evaluation. T. cruzi consensus and/or RIPA-positive sera from Central and South America were evaluated in enzyme immunoassays (EIAs). These included commercial panels from Boston Biomedica, Inc. (BBI) (n = 14), and HemaBio (n = 21). Other sources included RIPA-positive sera from the American Red Cross (ARC) (n = 42), as well as from Chile. Sera were tested with the multiepitope recombinant TcF. All but one of the BBI samples were positive and 7 of 21 HemaBio samples and 6 of 42 ARC samples were low positive or negative. This observation indicated the need for additional antigens. To complement TcF reactivity, we tested the sera with peptides 30, 36, SAPA, and 1.1, 1.2, and 1.3 His fragments of 85-kDa trans-sialidase. We identified a promising combination of the tested antigens and constructed a single recombinant protein, ITC6, that enhanced the relative sensitivity in U.S. blood donor sera compared to that of TcF. The data on its evaluation using RIPA-confirmed positive sera in EIA and lateral flow immunoassay studies are presented, along with an additional recombinant protein, ITC8.2, with two additional sequences for peptide 1 and Kmp-11. The latter, when evaluated in a dipstick assay with consensus positive sera, had a sensitivity of 99.2% and a

  11. LINE-1 hypomethylation in cancer is highly variable and inversely correlated with microsatellite instability.

    Directory of Open Access Journals (Sweden)

    Marcos R H Estécio

    Full Text Available BACKGROUND: Alterations in DNA methylation in cancer include global hypomethylation and gene-specific hypermethylation. It is not clear whether these two epigenetic errors are mechanistically linked or occur independently. This study was performed to determine the relationship between DNA hypomethylation, hypermethylation and microsatellite instability in cancer. METHODOLOGY/PRINCIPAL FINDINGS: We examined 61 cancer cell lines and 60 colorectal carcinomas and their adjacent tissues using LINE-1 bisulfite-PCR as a surrogate for global demethylation. Colorectal carcinomas with sporadic microsatellite instability (MSI, most of which are due to a CpG island methylation phenotype (CIMP and associated MLH1 promoter methylation, showed in average no difference in LINE-1 methylation between normal adjacent and cancer tissues. Interestingly, some tumor samples in this group showed increase in LINE-1 methylation. In contrast, MSI-showed a significant decrease in LINE-1 methylation between normal adjacent and cancer tissues (P<0.001. Microarray analysis of repetitive element methylation confirmed this observation and showed a high degree of variability in hypomethylation between samples. Additionally, unsupervised hierarchical clustering identified a group of highly hypomethylated tumors, composed mostly of tumors without microsatellite instability. We extended LINE-1 analysis to cancer cell lines from different tissues and found that 50/61 were hypomethylated compared to peripheral blood lymphocytes and normal colon mucosa. Interestingly, these cancer cell lines also exhibited a large variation in demethylation, which was tissue-specific and thus unlikely to be resultant from a stochastic process. CONCLUSION/SIGNIFICANCE: Global hypomethylation is partially reversed in cancers with microsatellite instability and also shows high variability in cancer, which may reflect alternative progression pathways in cancer.

  12. High blood levels of persistent organic pollutants are statistically correlated with smoking

    DEFF Research Database (Denmark)

    Deutch, Bente; Hansen, Jens C.

    1999-01-01

    Persistent Organic Pollutants (11 pesticides and 14 PCB-congeners), and heavy metals (Cd, Cu, Hg, Pb, Se, and Zn) were determined in 175 pregnant women and 160 newborn infants (umbilical cord blood) from Disko Bay, Greenland, 1994-96. Among these, 135 women filled out questionnaires about drinking......, smoking and intake of traditional Inuit food. Multiple linear regression analyses showed highly significant positive associations between the mothers' smoking status (never, previous, present) and plasma concentrations of all the studied organic pollutants both in maternal blood and umbilical cord blood...

  13. HIGH-RESOLUTION ULTRASONOGRAPHY OF SHOULDER FOR ROTATOR CUFF TEAR: CORRELATION WITH ARTHROSCOPIC FINDINGS

    Directory of Open Access Journals (Sweden)

    Vishnumurthy H. Y

    2016-09-01

    Full Text Available INTRODUCTION Rotator cuff disease is the most common cause of shoulder pain. Ultrasonography being non-invasive, widely available, more cost-effective method and is the first choice in imaging of rotator cuff tears. Arthroscopy of shoulder is considered as the gold standard for diagnosis of rotator cuff tears. Objective of this study was to compare the diagnostic accuracy of high-resolution ultrasonography of shoulder for rotator cuff tears with arthroscopy of shoulder. METHODS Thirty patients clinically suspected to have rotator cuff tear who underwent ultrasonography and arthroscopy of shoulder were included in the study. Duration of study was for two years. All ultrasonography examinations were conducted in ultrasound machine using GE Voluson 730 PRO high frequency (10-12 MHz linear array transducer done by two experienced radiologists. Arthroscopies were done by two experienced shoulder arthroscopic surgeons. RESULTS Age of the patients with rotator cuff tears ranged from 40 to 80 years. 57% were females and 43% were males among the patients who had rotator cuff tears. 71.43% of the rotator cuff tears were found in the dominant arm. 64.28% of patients with rotator cuff tear had given history of fall or trauma to the corresponding shoulder within 6 months prior to presentation. 39.28% of patients who had rotator cuff tears were known diabetics. Supraspinatus tendon was the most commonly affected tendon, followed by infraspinatus and subscapularis tendons. For overall detection of rotator cuff tears, ultrasonography in comparison with the arthroscopy has sensitivity and specificity of 92.85% and 100%. For detection of full thickness rotator cuff tear, its sensitivity and specificity was 94.73% and 100% and for partial thickness rotator cuff tears 76.92% and 100%. Ultrasonography has 100% sensitivity and specificity for detection of supraspinatus full thickness tear. For supraspinatus partial thickness tear, sensitivity and specificity was 88

  14. Internality and externality correlates of potential drivers among high school pupils in Holon (Israel).

    Science.gov (United States)

    Brook, U; Weitzman, A

    1994-01-01

    Car accidents are the leading causes of death and handicap among adolescents and young adults. Thirty-six pupils from the last class in high school (in the age group 17-18 years) have attended lectures with explanations concerning the consequences of car accidents by physicians of rehabilitation centers. They also were taken on a one-day visit to such a center. They have seen and talked with persons who were severely handicapped because of car accidents, and have followed the physical therapists and occupational healing therapists throughout their work day. The pupils completed the Rotter and Montag Internality-Externality Scale questionnaire before and after the meeting and staging with the handicaps, and the results showed an increase of 10.28% in their Internal focus of control. The conclusion is that confrontation of young future drivers with handicaps as a result of car accidents in rehabilitation centers should be a routine and regular habit during the last classes of high school.

  15. Jet quenching and γ-jet correlation in high-energy heavy-ion collisions

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Xin-Nian [Key Laboratory of Quark and Lepton Physics (MOE) and Institute of Particle Physics, Central China Normal University, Wuhan 430079 (China); Nuclear Science Division Mailstop 70R0319, Lawrence Berkeley National Laboratory, Berkeley, CA 94740 (United States); Zhu, Yan [Departamento de Física de Partículas and IGFAE, Universidade de Santiago de Compostela, E-15706 Santiago de Compostela, Galicia (Spain)

    2014-12-15

    Medium modification of γ-tagged jets in high-energy heavy-ion collisions is investigated within a linearized Boltzmann transport model which includes both elastic parton scattering and induced gluon emission. In Pb + Pb collisions at √(s)=2.76 TeV, a γ-tagged jet is seen to lose 15% of its energy at 0–10% central collisions. Simulations also point to a sizable azimuthal angle broadening of γ-tagged jets at the tail of a distribution which should be measurable when experimental errors are significantly reduced. An enhancement at large z{sub jet}=p{sub L}/E{sub jet} in jet fragmentation function at the Large Hadron Collider (LHC) can be attributed to the dominance of leading particles in the reconstructed jet. A γ-tagged jet fragmentation function is shown to be more sensitive to jet quenching, therefore a better probe of the jet transport parameter.

  16. Correlating Molecular Structures with Transport Dynamics in High-Efficiency Small-Molecule Organic Photovoltaics.

    Science.gov (United States)

    Peng, Jiajun; Chen, Yani; Wu, Xiaohan; Zhang, Qian; Kan, Bin; Chen, Xiaoqing; Chen, Yongsheng; Huang, Jia; Liang, Ziqi

    2015-06-24

    Efficient charge transport is a key step toward high efficiency in small-molecule organic photovoltaics. Here we applied time-of-flight and organic field-effect transistor to complementarily study the influences of molecular structure, trap states, and molecular orientation on charge transport of small-molecule DRCN7T (D1) and its analogue DERHD7T (D2). It is revealed that, despite the subtle difference of the chemical structures, D1 exhibits higher charge mobility, the absence of shallow traps, and better photosensitivity than D2. Moreover, charge transport is favored in the out-of-plane structure within D1-based organic solar cells, while D2 prefers in-plane charge transport.

  17. Ab interno sclerostomy with a high-powered argon endolaser. Clinicopathologic correlation.

    Science.gov (United States)

    Jaffe, G J; Mieler, W F; Radius, R L; Kincaid, M C; Massaro, B M; Abrams, G W

    1989-08-01

    A high-powered argon blue-green laser coupled to a 300-microns quartz fiberoptic probe was used to create an ab interno sclerostomy in a patient undergoing enucleation for a blind painful eye. Despite the presence of diffuse rubeosis, 360 degrees peripheral anterior synechiae, and superior conjunctival scarring, it was possible to create a full-thickness defect from the anterior chamber angle to the subconjunctival space without operative complications. Six laser applications were required using 8 W of power per pulse and 0.1-second pulse duration. The eye was enucleated immediately after the laser procedure, prepared for light microscopy, and sectioned serially. Histologic analysis demonstrated a patent fistula approximately 300 microns in diameter with sharp wound margins. Tissue damage was localized to within 150 microns of the sclerostomy. The overlying conjunctiva was intact.

  18. High-resolution computed tomography of cholesteatoma of the middle ear. CT, otological, and surgical correlation

    Energy Technology Data Exchange (ETDEWEB)

    Ishii, Kiyoshi; Fukusumi, Akio; Okudera, Toshio; Kato, Toshihiko; Soda, Toyoji

    1988-08-01

    The high-resolution computed tomography (CT) appearances of 72 consecutive cases (92 ears) of chronic otomastoiditis were reviewed. The cholesteatomas were verified surgically and/or otologically in 35 of these 92 ears. Discussion was made with special emphasis on the differential diagnosis of cholesteatoma of the middle ear from the non-cholesteatoma otitis media. The CT findings suggestive of cholesteatoma were as follows: the definitive findings was of a soft-tissue opacity filling Purssak's space, with a medial displacement of the malleus and the incus; the possible findings were 1) a bony erosion of the wall of the middle ear cavity, 2) a partial or complete disappearance of the malleus and/or the incus, and 3) an opacification of Purssak's space and the superomedial aspect of the external auditory meatus.

  19. High resolution energy-angle correlation measurement of hard x rays from laser-Thomson backscattering.

    Science.gov (United States)

    Jochmann, A; Irman, A; Bussmann, M; Couperus, J P; Cowan, T E; Debus, A D; Kuntzsch, M; Ledingham, K W D; Lehnert, U; Sauerbrey, R; Schlenvoigt, H P; Seipt, D; Stöhlker, Th; Thorn, D B; Trotsenko, S; Wagner, A; Schramm, U

    2013-09-13

    Thomson backscattering of intense laser pulses from relativistic electrons not only allows for the generation of bright x-ray pulses but also for the investigation of the complex particle dynamics at the interaction point. For this purpose a complete spectral characterization of a Thomson source powered by a compact linear electron accelerator is performed with unprecedented angular and energy resolution. A rigorous statistical analysis comparing experimental data to 3D simulations enables, e.g., the extraction of the angular distribution of electrons with 1.5% accuracy and, in total, provides predictive capability for the future high brightness hard x-ray source PHOENIX (photon electron collider for narrow bandwidth intense x rays) and potential gamma-ray sources.

  20. High blood levels of persistent organic pollutants are statistically correlated with smoking

    DEFF Research Database (Denmark)

    Deutch, Bente; Hansen, Jens C.

    1999-01-01

    Persistent Organic Pollutants (11 pesticides and 14 PCB-congeners), and heavy metals (Cd, Cu, Hg, Pb, Se, and Zn) were determined in 175 pregnant women and 160 newborn infants (umbilical cord blood) from Disko Bay, Greenland, 1994-96. Among these, 135 women filled out questionnaires about drinking......, smoking and intake of traditional Inuit food. Multiple linear regression analyses showed highly significant positive associations between the mothers' smoking status (never, previous, present) and plasma concentrations of all the studied organic pollutants both in maternal blood and umbilical cord blood....... Traditional food and not the tobacco is known to be the source of the contaminants. But smoking may influence the enzymatic turnover of toxic substances....

  1. Preparation of highly exfoliated polyester-clay nanocomposites: process-property correlations.

    Science.gov (United States)

    Dalir, Hamid; Farahani, Rouhollah D; Nhim, Vireya; Samson, Benjamin; Lévesque, Martin; Therriault, Daniel

    2012-01-10

    A large number of polyester nanocomposite batches featuring different kinds of nanoclay surface modifiers and up to 6 wt % nanoclay were manufactured using a solvent-based technique. Montmorillonite platelets modified with ammonium ions of different chemical architectures were examined to study the effect of ammonium ions on the extent of surface reactions with long-chain fatty acids. The ammonium montmorillonite was first dispersed and suspended in acetone. This suspension was further esterificated with dotriacontanoic (lacceroic) acid to form high density brushes on the clay surface. This led to achieving higher basal plane spacing of the montmorillonite platelets due to the reduction of electrostatic interactions holding them. The outcome of the surface esterification was analyzed by Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD). The esterificated ammonium-modified clays were then mixed by five different mixing strategies based on the use of a three-roll mill mixer (TRM) and/or ultrasonication (US) to obtain the desired polyester-nanoclay dispersion, intercalation, and exfoliation. The dispersion states of the modified nanoclay in polymer were characterized from XRD, scanning electron microscopy (SEM), and low and high magnification transmission electron microscopy (TEM). Mechanical, thermal, and barrier properties of the resulting composites were experimentally characterized. The Mori-Tanaka method along with an orientation distribution function was used to verify the experimental effective stiffness of the polyester nanocomposite systems. The aspect ratio of nanoclays and their level of intercalation and/or exfoliation after mixing were also confirmed by the comparison of the experimental diffusivity results with those of Fick's diffusion model. Systems having 4 and 6 wt % esterificated ammonium nanoclay and prepared according to a combined TRM/US mixing procedure showed optimal performance with balanced properties and processing

  2. A review of family and environmental correlates of health behaviors in high-risk youth.

    Science.gov (United States)

    Lawman, Hannah G; Wilson, Dawn K

    2012-06-01

    Disparities in the prevalence of obesity in youth place minority and low socioeconomic status youth at increased risk for the development of chronic disease, such as metabolic syndrome and type 2 diabetes. Contributing factors to the increases in obesity include a decline in positive health behaviors, such as making healthy dietary choices, engaging in physical activity, and limiting sedentary behaviors. Family and physical environmental contextual factors related to health behaviors are increasingly the focus of health behavior interventions in line with the bioecological model that encourages a system-focused perspective on understanding health behavior influences. Physical environmental characteristics, such as home and neighborhood characteristics and resources, provide the tangible means to support health behaviors and are important contextual variables to consider that may increase intervention effectiveness. Therefore, the current review seeks to highlight the importance of investigating influences of behavior beyond individual characteristics in understanding factors related to the risk of developing metabolic syndrome and type 2 diabetes in youth at high risk for developing chronic disease. The current study reviews the non-intervention literature on family and physical environmental factors related to health behaviors (i.e., diet, physical activity, and sedentary behavior) in youth who are considered to be at-risk for developing metabolic syndrome and type 2 diabetes. Results on 38 published articles of diet, physical activity, and sedentary behaviors showed support for the role of parenting and physical environmental factors, particularly parental monitoring and neighborhood context, such as social cohesion, as they relate to health behaviors in high-risk youth. Implications and recommendations for future research are discussed.

  3. Baseline correlates of insulin resistance in inner city high-BMI African-American children.

    Science.gov (United States)

    Raman, Aarthi; Fitch, Mark D; Hudes, Mark L; Lustig, Robert H; Murray, Carolyn B; Ikeda, Joanne P; Fleming, Sharon E

    2008-09-01

    To characterize the influence of diet-, physical activity-, and self-esteem-related factors on insulin resistance in 8- 10-year-old African-American (AA) children with BMI greater than the 85th percentile who were screened to participate in a community-based type 2 diabetes mellitus (T2DM) prevention trial. In 165 subjects, fasting glucose- and insulin-derived values for homeostasis model assessment of insulin resistance (HOMA-IR) assessed insulin resistance. Body fatness was calculated following bioelectrical impedance analysis, and fitness was measured using laps from a 20-m shuttle run. Child questionnaires assessed physical activity, dietary habits, and self-esteem. Pubertal staging was assessed using serum levels of sex hormones. Parent questionnaires assessed family demographics, family health, and family food and physical activity habits. Girls had significantly higher percent body fat but similar anthropometric measures compared with boys, whereas boys spent more time in high-intensity activities than girls. Scores for self-perceived behavior were higher for girls than for boys; and girls desired a more slender body. Girls had significantly higher insulin resistance (HOMA-IR), compared with boys (P < 0.01). Adjusting for age, sex, pubertal stage, socioeconomic index (SE index), and family history of diabetes, multivariate regression analysis showed that children with higher waist circumference (WC) (P < 0.001) and lower Harter's scholastic competence (SC) scale (P = 0.044) had higher insulin resistance. WC and selected self-esteem parameters predicted insulin resistance in high-BMI AA children. The risk of T2DM may be reduced in these children by targeting these factors.

  4. Correlation Between Birth Defects and Dietary Nutrition Status in a High Incidence Area of China1

    Institute of Scientific and Technical Information of China (English)

    BAO-YUAN ZHANG; QING-SHAN ZHANG; JIN ZHAO; YU-FU QIN; XIU-FENG YANG; GONG CHEN; JU-FEN LIU; XIN-MING SONG; XIAO-YING ZHENG; TING ZHANG; LIANG-MING LIN; FANG WANG; RUO-LEI XIN; XUE GU; YU-NA HE; DONG-MEI YU; PEI-ZHEN LI

    2008-01-01

    Objective To investigate the association between birth defects and dietary nutrient intake in a high risk area of China.Methods A dietary survey was performed and serum folic acid was measured in women whose pregnancy was affected by neural tube defects(NTDs)or unaffected by any birth defects(BDs)in Zhongyang and Jiaokou Counties in Shanxi Province of China.Results The local average censureption of foods including dark green vegetables,fluits,fat and meat,and nutrient intake(e.g.energy,protein,retinol,riboflavin,vitamin E,and selenium)were lower than the national average level.In women of childbearing age,these regions,the intake of nutrients was much lower than the recommended nutrient intake(9%-77%)The case-centrel dietary nutrition smdv of women whose pregnancy was affected bv BDs(including MTDs and congenital heart defects)demonstrated that,in early pregnancy,adequate nutrition(I.e.eating meat,fresh vegetables,fruit more than once a week)was a protective factor,while eating germinated potatoes was a risk factor.The geometrical mean(p5-p95)of serum folic acid in women with NTD birth defects was 9.6 nmol/L(3.6,23.03),which was significantly lower than that in normal women(14.03 nmol/L). Conclusion Wemen of childbearing age in the two counties of Shanxi Province,Chim,have a marked insufficient intake of some nutrients,especially folic acid,zinc,vitamins A and B12.This nutrient deficiency may be an important risk factor for the high prevalence of birth defects in these regions.Therefore,adequate dietary nutrition in early pregnancy can prevent BDs.

  5. Computing highly correlated positions using mutual information and graph theory for G protein-coupled receptors.

    Directory of Open Access Journals (Sweden)

    Sarosh N Fatakia

    Full Text Available G protein-coupled receptors (GPCRs are a superfamily of seven transmembrane-spanning proteins involved in a wide array of physiological functions and are the most common targets of pharmaceuticals. This study aims to identify a cohort or clique of positions that share high mutual information. Using a multiple sequence alignment of the transmembrane (TM domains, we calculated the mutual information between all inter-TM pairs of aligned positions and ranked the pairs by mutual information. A mutual information graph was constructed with vertices that corresponded to TM positions and edges between vertices were drawn if the mutual information exceeded a threshold of statistical significance. Positions with high degree (i.e. had significant mutual information with a large number of other positions were found to line a well defined inter-TM ligand binding cavity for class A as well as class C GPCRs. Although the natural ligands of class C receptors bind to their extracellular N-terminal domains, the possibility of modulating their activity through ligands that bind to their helical bundle has been reported. Such positions were not found for class B GPCRs, in agreement with the observation that there are not known ligands that bind within their TM helical bundle. All identified key positions formed a clique within the MI graph of interest. For a subset of class A receptors we also considered the alignment of a portion of the second extracellular loop, and found that the two positions adjacent to the conserved Cys that bridges the loop with the TM3 qualified as key positions. Our algorithm may be useful for localizing topologically conserved regions in other protein families.

  6. Preference and intake frequency of high sodium foods and dishes and their correlations with anthropometric measurements among Malaysian subjects.

    Science.gov (United States)

    Choong, Stella Sinn-Yee; Balan, Sumitha Nair; Chua, Leong-Siong; Say, Yee-How

    2012-06-01

    This study investigated the preference and intake frequency of a list of 15 commonly available high sodium Malaysian foods/dishes, discretionary salt use, and their possible association with demographics, blood pressures and anthropometric measurements among 300 Malaysian university students (114 males, 186 females; 259 ethnic Chinese, 41 Indians; 220 lean, 80 overweight). French fries and instant soup noodle were found to be the most preferred and most frequently consumed salty food, respectively, while salted fish was least preferred and least frequently consumed. Males had a significantly higher intake frequency of at least 6 of the salty foods, but the preference of most salty foods was not significantly different between genders. Ethnic Chinese significantly preferred more and took more frequently traditional and conventional Malaysian foods like asam laksa (a Malaysian salty-sour-spicy noodle in fish stock), salted biscuits and salted vegetable, while Indians have more affinity and frequency towards eating salty Western foods. Body Mass Index was significantly negatively correlated with the intake frequency of canned/packet soup and salted fish while waist circumference was significantly positively correlated with the preference of instant noodle. Also, an increased preference of potato chips and intake frequency of salted biscuits seemed to lead to a decreased WHR. Other than these, all the other overweight/obesity indicators did not seem to fully correlate with the salty food preference and intake frequency. Nevertheless, the preference and intake frequency of asam laksa seemed to be significant negative predictors for blood pressures. Finally, increased preference and intake frequency of high sodium shrimp paste (belacan)-based foods like asam laksa and belacan fried rice seemed to discourage discretionary salt use. In conclusion, the preference and intake frequency of the high sodium belacan-based dish asam laksa seems to be a good predictor for ethnic

  7. Severity of sepsisis is correlated with the elevation of serum high-mobility group box 1 in rats

    Institute of Scientific and Technical Information of China (English)

    HOU Li-chao; XIONG Li-ze; QIN Ming-zhe; ZHENG Li-na; LU Yan; WANG Qiang; PENG Dao-rong; YU Xin-ping; XIN Yu-chang; JI Gen-lin

    2009-01-01

    Background Sepsis is a leading cause of death in the intensive care units. The late inflammatory cytokine,high-mobility group box 1 (HMGB1), plays a critical role in sepsis. In the present study, we investigated the association between the serum HMGB1 levels and the severity of organ injury in the lipopolysaccharide-induced sepsis in rats.Methods To produce an animal model of sepsis with different degree of organ injury, animals were treated with three different doses of lipopolysaccharide (4, 8 and 16 mg/kg), and the animals in control group were treated with the same volume of the vehicle (saline). The levels of serum HMGB1 were measured at 0, 2, 4, 8, 16, 24, 32 and 48 hours after lipopolysaccharide (LPS) or vehicle injection, meanwhile the biochemical and histopathological indicators for the severity of organ injury were assessed.Results The level of HMGB1 had a positive, high correlation with the abnormal changes of serum cardiac troponin Ⅰ, alanine aminotransferase, aspartate aminotransferase, creatinine and blood urea nitrogen, as well as the pathologic scores of heart, lung, liver and kidney.Conclusions The level of serum HMGB1 is highly correlated with the severity of sepsis in rats, suggesting that HMGB1 could serve as a valuable adjunct in the diagnosis and management of sepsis.

  8. Evaluation of sperm head shape at high magnification revealed correlation of sperm DNA fragmentation with aberrant head ellipticity and angularity.

    Science.gov (United States)

    Utsuno, Hiroki; Oka, Kenji; Yamamoto, Ayako; Shiozawa, Tanri

    2013-05-01

    To test for an association between DNA fragmentation and head shape at high magnification in fresh motile spermatozoa. Observational study. Academic tertiary care center. A total of 60 men in our assisted reproductive program. Quantifying sperm head shape using elliptic Fourier analysis, and detecting DNA fragmentation by use of a terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay. Correlation between percentage of spermatozoa with abnormal head shape and percentage of DNA fragmentation. Elliptic Fourier analysis decomposed sperm head shapes into four quantitative parameters: ellipticity, anteroposterior (AP) symmetry, lateral symmetry, and angularity. The DNA fragmentation was statistically significantly correlated with abnormal angularity, and moderately with abnormal ellipticity but not with abnormal AP symmetry or lateral symmetry. Forward stepwise multiple logistic regression analysis revealed a statistically significantly higher percentage of DNA fragmentation in spermatozoa with abnormal ellipticity and abnormal angularity than in spermatozoa with normal-shaped head (6.1% and 5.4% vs. 2.8%). Spermatozoa with large nuclear vacuoles also correlated with sperm DNA fragmentation, and had a statistically significantly higher percentage of DNA fragmentation (4.7%). Among the morphologic features of the sperm head, abnormal ellipticity, angularity, and large nuclear vacuoles are associated with DNA fragmentation. Copyright © 2013 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

  9. Quasi-static tensile deformation and fracture behavior of a highly particle-filled composite using digital image correlation method

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    Polymer bonded explosives (PBXs) are highly particle-filled composite materials.This paper experimentally studies the tensile deformation and fracture behavior of a PBX simulation by using the semi-circular bending (SCB) test.The deformation and fracture process of a pre-notched SCB sample with a random speckle pattern is recorded by a charge coupled device camera.The displacement and strain fields on the observed surface during the loading process are obtained by using the digital image correlation method....

  10. First example of a high-level correlated calculation of the indirect spin-spin coupling constants involving tellurium

    DEFF Research Database (Denmark)

    Rusakov, Yury Yu; Krivdin, Leonid B.; Østerstrøm, Freja From;

    2013-01-01

    This paper documents a very first example of a high-level correlated calculation of spin-spin coupling constants involving tellurium taking into account relativistic effects, vibrational corrections and solvent effects for the medium sized organotellurium molecules. The 125Te-1H spin-spin coupling...... of spin-spin coupling constants involving tellurium, was developed. The SOPPA methods show much better performance as compared to 15 those of DFT, if relativistic effects calculated within the ZORA scheme are taken into account. Vibrational and solvent corrections are next to negligible, while...

  11. High energy behavior of a six-point R-current correlator in N=4 supersymmetric Yang-Mills theory

    Energy Technology Data Exchange (ETDEWEB)

    Bartels, Jochen; Hentschinski, Martin; Mischler, Anna-Maria [Hamburg Univ. (Germany). 2. Inst. fuer Theoretische Physik; Ewerz, Carlo [Heidelberg Univ. (Germany). Inst. fuer Theoretische Physik; GSI Helmholtzzentrum fuer Schwerionenforschung, Darmstadt (Germany). ExtreMe Matter Institute EMMI; Bielefeld Univ. (Germany). Fakultaet fuer Physik; European Centre for Theoretical Studies in Nuclear Physics and Related Areas (ECT), Villazzano (Italy)

    2009-12-15

    We study the high energy limit of a six-point R-current correlator in N=4 supersymmetric Yang-Mills theory for finite N{sub c}. We make use of the framework of perturbative resummation of large logarithms of the energy. More specifically, we apply the (extended) generalized leading logarithmic approximation. We find that the same conformally invariant two-to-four gluon vertex occurs as in non-supersymmetric Yang-Mills theory. As a new feature we find a direct coupling of the four-gluon t-channel state to the R-current impact factor. (orig.)

  12. Efficient Identification of Objects Carrying Elements of High-Order Symmetry By Using Correlated Orbital Angular Momentum (OAM States

    Directory of Open Access Journals (Sweden)

    Sergienko Alexander V.

    2014-01-01

    The potential for efficient identification of objects carrying elements of high-order symmetry using correlated orbital angular momentum (OAM states is demonstrated. The enhanced information capacity of this approach allows the recognition of specific spatial symmetry signatures present in objects with the use of fewer resources than in a conventional pixel-by-pixel imaging, representing the first demonstration of compressive sensing using OAM states. This approach demonstrates the capability to quickly evaluate multiple Fourier coefficients directly linked with the symmetry features of the object. The results suggest further application in small-scale biological contexts where symmetry and small numbers of noninvasive measurements are important.

  13. High temperature conductance mapping for correlation of electrical properties with micron-sized chemical and microstructural features

    DEFF Research Database (Denmark)

    Hansen, Karin Vels; Norrman, Kion; Jacobsen, Torben

    2016-01-01

    High temperature AC conductance mapping is a scanning probe technique for resolving local electrical properties in microscopic areas. It is especially suited for detecting poorly conducting phases and for ionically conducting materials such as those used in solid oxide electrochemical cells....... Secondary silicate phases formed at the edge of lanthanum strontium manganite microelectrodes are used as an example for correlation of chemical, microstructural and electrical properties with a spatial resolution of 1–2 µm to demonstrate the technique. The measurements are performed in situ in a controlled...

  14. Protozoan growth rates on secondary-metabolite-producing Pseudomonas spp. correlate with high-level protozoan taxonomy

    DEFF Research Database (Denmark)

    Pedersen, Annette L.; Winding, Anne; Altenburger, Andreas

    2011-01-01

    Different features can protect bacteria against protozoan grazing, for example large size, rapid movement, and production of secondary metabolites. Most papers dealing with these matters focus on bacteria. Here, we describe protozoan features that affect their ability to grow on secondary...... with membrane-bound metabolites. Interestingly, protozoan response seemed to correlate with high-level protozoan taxonomy, and amoeboid taxa tolerated a broader range of Pseudomonas strains than did the non-amoeboid taxa. This stresses the importance of studying both protozoan and bacterial characteristics...

  15. HIGH DYNAMIC RANGE OBSERVATIONS OF SOLAR CORONAL TRANSIENTS AT LOW RADIO FREQUENCIES WITH A SPECTRO-CORRELATOR

    Energy Technology Data Exchange (ETDEWEB)

    Hariharan, K.; Ramesh, R.; Kathiravan, C.; Rajalingam, M. [Indian Institute of Astrophysics, Bangalore-560034 (India); Abhilash, H. N., E-mail: khariharan@iiap.res.in [Poornaprajna College, Udupi-576101 (India)

    2016-02-15

    A new antenna system with a digital spectro-correlator that provides high temporal, spectral, and amplitude resolutions has been commissioned at the Gauribidanur Observatory near Bangalore in India. Presently, it is used for observations of the solar coronal transients in the scarcely explored frequency range ≈30–15 MHz. The details of the antenna system, the associated receiver setup, and the initial observational results are reported. Some of the observed transients exhibited quasi-periodicity in their time profiles at discrete frequencies. Estimates of the associated magnetic field strength (B) indicate that B ≈ 0.06–1 G at a typical frequency such as 19.5 MHz.

  16. Correlation analysis of high precision blood flow imaging in secondary parathyroid function in maintenance hemodialysis patients

    Institute of Scientific and Technical Information of China (English)

    Wen-Ze Du; Le Chen; Xiao-Yun Wu

    2016-01-01

    Objective:To investigate the value of high precision blood flow imaging (Fine-Flow) in secondary parathyroid function (SHPT) in patients with maintenance hemodialysis (MHD). Methods: A total of 95 MHD patients with SHPT in our hospital from January 2015 to June 2016 were selected as the research object. According to the Fine-Flow examination of parathyroid gland, 73 cases were divided into display group, 22 cases were not shown; Display group according to the hyperplasia of parathyroid diameter were divided into 1.5 cm group of 17 cases; display group according to the blood flow into the rich group of 41 cases, not rich group of 32 cases; according to whether calcification were divided into calcification group of 43 cases, non calcified group of 30 cases. CDFI was used for the anterior region of neck transverse and longitudinal scanning, check the thyroid and around the dorsal lobes.The size, echo, lesion number and blood flow were measured, parathyroid hormone (PTH), serum calcium (Ca), phosphorus (P), and calculate the Ca and P product (Ca×P) were measured.Results: PTH and Ca of the display group were significantly higher than that of the non display group, and differences in P and Ca×P were not statistically significant; Parathyroid diameter >1.5 cm PTH levels were significantly higher than the other three groups, diameter 1-1.5 cm group and >1.5 cm group Ca, diameter Ca×P was higher than that in group <5 cm and 0.5-1.0 cm group, difference in P of four groups was not statistical significant; group PTH, P, abundant blood flow Ca×P were not significantly higher than the rich group, difference in P of two groups was no statistical significance; group Ca was significantly higher than that of calcification calcification group, differences in PTH, P, Ca×P of the two groups were not statistically significant.Conclusions:MHD patients with SHPT, parathyroid Fine-Flow display rate is high, and has the characteristic performance. Its operation is simple, non

  17. High-Precision U-Pb Geochronology and Correlation: An example Using the Neoproterozic-Cambrian Transition

    Science.gov (United States)

    Bowring, S. A.; Grotzinger, J. P.; Amthor, J.; Martin, M. E.

    2001-05-01

    The precise, global correlation of Precambrian and Paleozoic sedimentary rocks can be achieved using temporally calibrated chemostratigraphic records. This approach is essential for determining rates and causes of environmental and faunal change, including mass extinctions. For example, The Neoproterozoic is marked by major environmental change, including periods of global glaciation, large fluctuations in the sequestration of carbon and major tectonic reorganization followed by the explosive diversification of animals in the earliest Cambrian. The extreme climatic change associated with these glaciations have been implicated as a possible trigger for the Cambrian explosion. The recognition of thin zircon-bearing air-fall ash in Neoproterozoic and Cambrian rocks has allowed the establishment of a high-precision temporal framework for animal evolution and is helping to untangle the history of glaciations. In some cases analytical uncertainties translate to age uncertainties of less than 1 Ma and when integrated with chemostratigraphy, the potential for global correlations at even higher resolution. Progress in the global correlation of Neoproterozoic strata has been achieved through the use of C and Sr isotope chemostratigraphy although it has been hampered by a lack of precise geochronological and faunal control. For example, the period from ca 800-580 Ma is characterized by at least two and perhaps as many as four glacial events that are interpreted by many to be global glaciations on a "Snowball Earth". A lack of precise chronological constraints on the number and duration of glaciations, multiple large excursions in the carbon isotopic record, and an absence of detailed biostratigraphy have complicated global correlation and hindered our understanding of this important period of Earth history. However, the ongoing integration of chemostratigraphic and geochronological data are improving temporal resolution and detailed correlations. These data are critical for

  18. CORRELATION OF BREAST CANCER AND SERUM HIGH DENSITY LIPOPROTEIN CHOLESTEROL LEVEL: A SINGLE CENTRE STUDY

    Directory of Open Access Journals (Sweden)

    Anjali

    2015-12-01

    Full Text Available Breast cancer is the most common site specific cancer in women. Lots of etiological factors have been suggested regarding its causation. The risk is influenced by obesity, parity, exogenous and endogenous hormones, exposure to chemicals and radiation and many more. Various studies suggest that as HDL-C seems to be cardio protective, it is also protective for breast cancer. Serum HDL-C levels are found to be low in breast cancer patients. We studied this hypothesis in local population of Southern Rajasthan and nearby region to see if low serum HDL-C is associated with increased risk of breast cancer. We studied serum HDL-C level in 50 female patients of breast cancer along with their menopausal status and compared it to their respective controls. We found that breast cancer patients had significantly low level of serum HDL-C and presented in advanced stage of cancer. It supports that low serum HDL-C level is associated with increased risk of breast cancer. So one should think about those dietary and lifestyle measures, which maintain high serum HDL-C level so that it might become preventive measure for breast cancer.

  19. High exposure to Tunga penetrans (Linnaeus, 1758 correlates with intensity of infestation

    Directory of Open Access Journals (Sweden)

    Hermann Feldmeier

    2006-02-01

    Full Text Available Tungiasis is a parasitic skin disease widespread in resource-poor urban and rural communities in Brazil. Inhabitants of an urban slum in Northeast Brazil were examined for the presence of tungiasis lesions and followed-up twice a week for a period of three weeks. Each time the number, stages, and topographic localization of lesions were recorded on a documentation sheet. The infestation rate (number of newly embedded sand fleas per individual and day remained stable during the observation period. The infestation rate was significantly related to the intensity of infestation (total number of lesions present (rho = 0.70, p < 0.0001 and the proportion of viable lesions (rho = 0.28, p < 0.0001. The results indicate that in an endemic area the infestation intensity and the proportion of viable lesions can be used as a proxy to assess the exposure of individuals at risk for tungiasis. Persistently high infestation rates during the transmission season favour the use of prevention measures against invading sand fleas (such as a repellent rather than a drug to kill already embedded parasites.

  20. THE IMPORTANCE OF QUALITY MANAGEMENT SYSTEM OF THE HIGH EDUCATION AND CORRELATION WITH ISO 9000 STANDARDS

    Directory of Open Access Journals (Sweden)

    Darko Petkovic

    2007-03-01

    Full Text Available The modern concept of quality management understands construction and implementation of an internal system of organization, respectively of a system of the quality management (QMS. This means arranging the business system which treats the quality through all aspects of making the business and by which the organization is directed by the demands of its users. This again comes from the definition itself of the quality is defined from "up side", and that it expresses an expert opinion, is the matter of past in all the fields of work and business. The quality must be related to users function, respectively to users satisfaction. From this trends are not exempted neither the higher education organization dedicates an important part to the quality management. Related to that, numerous reports, analyses and discussions, carried out in the framework of actual reform, show that the important changes of existing state are necessary, in view of the organization and advancement of higher education. In the work are assumed the experiences of the international quality standards in higher education institutions, considering the significant specific particularity of our high education reality. The former can help the more efficient adaptation to the demands of the Bologna process.