Functional update of the auxiliary proteins PsbW, PsbY, HCF136, PsbN, TerC and ALB3 in maintenance and assembly of PSII

Directory of Open Access Journals (Sweden)

Magdalena ePlöchinger

2016-04-01

Full Text Available Assembly of Photosystem (PS II in plants has turned out to be a highly complex process which, at least in part, occurs in a sequential order and requires many more auxiliary proteins than subunits present in the complex. Owing to the high evolutionary conservation of the subunit composition and the three-dimensional structure of the PSII complex, most plant factors involved in the biogenesis of PSII originated from cyanobacteria and only rarely evolved de novo. Furthermore, in chloroplasts the initial assembly steps occur in the non-appressed stroma lamellae, whereas the final assembly including the attachment of the major LHCII antenna proteins takes place in the grana regions. The stroma lamellae are also the place where part of PSII repair occurs, which very likely also involves assembly factors. In cyanobacteria initial PSII assembly also occurs in the thylakoid membrane, in so-called thylakoid centres, which are in contact with the plasma membrane. Here, we provide an update on the structures, localisations, topologies, functions, expression and interactions of the low molecular mass PSII subunits PsbY, PsbW and the auxiliary factors HCF136, PsbN, TerC and ALB3, assisting in PSII complex assembly and protein insertion into the thylakoid membrane.

Impairment of interferon regulatory factor-3 activation by hepatitis C virus core protein basic amino acid region 1.

Science.gov (United States)

Inoue, Kazuaki; Tsukiyama-Kohara, Kyoko; Matsuda, Chiho; Yoneyama, Mitsutoshi; Fujita, Takashi; Kuge, Shusuke; Yoshiba, Makoto; Kohara, Michinori

2012-11-30

Interferon regulatory factor-3 (IRF-3), a key transcriptional factor in the type I interferon system, is frequently impaired by hepatitis C virus (HCV), in order to establish persistent infection. However, the exact mechanism by which the virus establishes persistent infection has not been fully understood yet. The present study aimed to investigate the effects of various HCV proteins on IRF-3 activation, and elucidate the underlying mechanisms. To achieve this, full-length HCV and HCV subgenomic constructs corresponding to structural and each of the nonstructural proteins were transiently transfected into HepG2 cells. IFN-β induction, plaque formation, and IRF-3 dimerization were elicited by Newcastle disease virus (NDV) infection. The expressions of IRF-3 homodimer and its monomer, Ser386-phosphorylated IRF-3, and HCV core protein were detected by immunofluorescence and western blotting. IFN-β mRNA expression was quantified by real-time PCR (RT-PCR), and IRF-3 activity was measured by the levels of IRF-3 dimerization and phosphorylation, induced by NDV infection or polyriboinosinic:polyribocytidylic acid [poly(I:C)]. Switching of the expression of the complete HCV genome as well as the core proteins, E1, E2, and NS2, suppressed IFN-β mRNA levels and IRF-3 dimerization, induced by NDV infection. Our study revealed a crucial region of the HCV core protein, basic amino acid region 1 (BR1), to inhibit IRF-3 dimerization as well as its phosphorylation induced by NDV infection and poly (I:C), thus interfering with IRF-3 activation. Therefore, our study suggests that rescue of the IRF-3 pathway impairment may be an effective treatment for HCV infection. Copyright © 2012 Elsevier Inc. All rights reserved.

Sphingosine-1-Phosphate (S1P)-Related Response of Human Conjunctival Fibroblasts After Filtration Surgery for Glaucoma.

Science.gov (United States)

Aoyama-Araki, Yuka; Honjo, Megumi; Uchida, Takatoshi; Yamagishi, Reiko; Kano, Kuniyuki; Aoki, Junken; Aihara, Makoto

2017-04-01

To investigate levels of sphingosine-1-phosphate (S1P) in aqueous fluid samples taken before and after filtration surgery and S1P-induced human conjunctival fibroblast (HCF) responses. Levels of S1P and its related sphingophospholipids in aqueous fluid obtained immediately before and after filtration surgery were determined by liquid chromatography-tandem mass spectrometry. HCFs were used for all in vitro experiments. The expression of five S1P receptor subtypes in HCFs was examined by quantitative real-time PCR. The effect of S1P and receptor-specific antagonists on HCF viability and cell migration was assessed by WST-1 assay and scratch migration assay, respectively. Differentiation to myofibroblasts and extracellular matrix production was evaluated by examining changes in F-actin, α-smooth muscle actin (αSMA), and collagen expression with immunocytochemistry, Western blotting, and collagen accumulation assay, respectively. No significant S1P levels in the aqueous fluid samples were detectable immediately before surgery, but postoperative levels of several lysophospholipids, including S1P, dehydro-S1P, and sphingosine, were significantly increased to bioactive concentrations in aqueous fluid in the blebs (P S1P receptor subtypes was detected in HCFs. Although S1P levels did not influence HCF proliferation, S1P enhanced cell migration, which could be inhibited by the S1P2 antagonist JTE 013. F-actin, αSMA, and collagen expression was significantly increased by S1P stimulation and was reduced by JTE 013. Bioactive S1P concentrations were present in the aqueous fluid at the end of filtration surgery. S1P activated HCFs via S1P2 receptors. These results revealed the potential of S1P2 antagonists in preventing scarring after glaucoma filtration surgery.

Electrochemical behavior of ruthenium-hexacyanoferrate modified glassy carbon electrode and catalytic activity towards ethanol electro oxidation

Energy Technology Data Exchange (ETDEWEB)

Costa, Wendell M.; Marques, Aldalea L.B., E-mail: aldalea.ufma@hotmail.com [Universidade Federal do Maranhao (UFMA), Sao Luis, MA (Brazil). Departamento de Quimica Tecnologica; Cardoso, William S.; Marques, Edmar P.; Bezerra, Cicero W.B. [Universidade Federal do Maranhao (UFMA), Sao Luis, MA (Brazil). Departamento de Qumica; Ferreira, Antonio Ap. P. [Universidade Estadual Paulista Julio de Mesquita Filho (UNESP), Araraquara, SP (Brazil). Instituto de Quimica; Song, Chaojie; Zhang, Jiujun [Energy, Mining and Environment Portfolio, National Research Council of Canada, Vancouver, BC (Canada)

2013-04-15

Ruthenium-based hexacyanoferrate (RuHCF) thin film modified glassy carbon electrode was prepared by drop evaporation method. The RuHCF modified electrode exhibited four redox couples in strong acidic solution (pH 1.5) attributed to Fe(CN){sub 6}{sup 3-} ion and three ruthenium forms (Ru(II), Ru(III) and Ru(IV)), characteristic of ruthenium oxide compounds. The modified electrode displayed excellent electrocatalytic activity towards ethanol oxidation in the potential region where electrochemical processes Ru(III)-O-Ru(IV) and Ru(IV)-O-Ru(VI) occur. Impedance spectroscopy data indicated that the charge transfer resistance decreased with the increase of the applied potential and ethanol concentration, indicating the use of the RuHCF modified electrode as an ethanol sensor. Under optimized conditions, the sensor responded linearly and rapidly to ethanol concentration between 0.03 and 0.4 mol L{sup -1} with a limit of detection of 0.76 mmol L{sup -1}, suggesting an adequate sensitivity in ethanol analyses. (author)

Modulation of human melanoma cell proliferation and apoptosis by hydatid cyst fluid of Echinococcus granulosus

Directory of Open Access Journals (Sweden)

Gao X

2018-03-01

Full Text Available Xiang-Yang Gao,1,* Guang-Hui Zhang,2,* Li Huang3 1Department of Laboratory Medicine, Pu’er People’s Hospital, Pu’er, 2Department of Clinical Laboratory, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 3Department of General Surgery, Shanghai General Hospital, Shanghai, China *These authors contributed equally to this work Objective: The objective of this paper was to assess the effects of hydatid cyst fluid (HCF of Echinococcus granulosus on melanoma A375 cell proliferation and apoptosis.Methods: A375 cells were classified into five groups by in vitro culture: normal group, control group, 10% HCF group, 20% HCF group and 30% HCF group. Trypan blue staining method was employed to detect the toxicity of HCF. Effects of different concentrations of HCF on melanoma A375 cell proliferation at different time points were evaluated using the 3-(4,5-dimethylthiazol-2-yl-2,5-diphenyltetrazolium bromide assay. Flow cytometry and propidium iodide (PI staining were used to detect cell cycle, and Annexin-V/PI double staining method was used to determine A375 cell apoptotic rate. Western blotting was applied to detect the expression of phosphorylated extracellular regulated protein kinases, proliferating cell nuclear antigen (PCNA, cell-cycle-related proteins (cyclin A, cyclin B1, cyclin D1 and cyclin E and apoptosis-related proteins (Bcl-2, Bax and caspase-3.Results: HCF with a high concentration was considered as atoxic to A375 cells. HCF promoted A375 cell proliferation, and the effects got stronger with an increase in concentrations but was retarded after reaching a certain range of concentrations. HCF increased phosphorylation level and expression of extracellular regulated protein kinase, as well as PCNA expression. HCF also promoted the transferring progression of A375 cells from the G0/G1 phase to the S phase to increase the cell number in S phase and increased the expression of cyclin A, cyclin D1 and

From basic concepts to emerging technologies in regional anesthesia.

Science.gov (United States)

Dillane, Derek; Tsui, Ban C H

2010-10-01

The present article details how our understanding of the basic concepts of regional anesthesia has recently evolved. We will appraise current technological advances and question the commensurate nature of the relationship between tradition and innovation. Ultrasound localization has enhanced our understanding of the needle-nerve relationship. Intraneural injection of local anesthetic may occur with greater frequency than previously thought without inevitably leading to neurological complications. The ratio of neural to non-neural tissue varies both between and within nerves and may be an important determinant of neural injury. Ultrasonographic evidence of intraneural injection is subject to observer expertise and the resolution of the ultrasound image. Current ultrasound resolution capability does not reliably permit differentiation between intrafascicular and extrafascicular drug injection. Perineural electrical impedance may be a determinant of current threshold and conceivably distinguish between intraneural and extraneural tissue. Technology that enhances the sonographic image of both procedure needle and target nerve is the focus of current endeavors in ultrasound innovation.There is inconclusive evidence that the use of ultrasound technology has reduced the incidence of local anesthetic toxicity. Lipid emulsion therapy is now an accepted treatment for systemic local anesthetic toxicity. There are new reports on the development of an ultra long-acting local anesthetic agent that would permit lower doses and superannuate catheter-based continuous regional anesthesia techniques. Over the past decade, our understanding of the fundamental concepts of regional anesthesia continues to be challenged by emerging experimental and clinical evidence.

Learning and Motivation in Thailand: A Comparative Regional Study on Basic Education Ninth Graders

Science.gov (United States)

Loima, Jyrki; Vibulphol, Jutarat

2016-01-01

This qualitative research studied regional motivation and learning of the basic education 9th graders in Thailand. Second topic was the school size and its possible effect on motivation. Furthermore, the data gave an opportunity to discuss, whether international research on motivation and learning was valid in Thai classrooms. The informants were…

Wind power installations in Switzerland - Regional planning basics and impact; Windkraftanlagen in der Schweiz - Raumplanerische Grundlagen und Auswirkungen - Grundlagenbericht

Energy Technology Data Exchange (ETDEWEB)

Ott, W.; Kaufmann, Y.; Steiner, P. [Econcept AG, Zuerich (Switzerland); Gilgen, K.; Sartoris, A. [IRAP-HSR, Institut fuer Raumentwicklung an der Hochschule fuer Technik Rapperswil, Rapperswil (Switzerland)

2008-07-01

This report published by the Swiss Federal Office of Energy (SFOE) takes a look at the basics of regional planning and its impact on the construction of wind-energy installations in Switzerland. The authors state that the planning and realisation of wind turbine installations is often time and resource consuming: this document presents and discusses the results obtained in a project that aimed to supply consolidated knowledge on project-relevant basics and their effect with respect to wind-energy installations. Experience gained in Switzerland and in other countries is discussed. This report on the basics of wind-energy planning with its detailed information formed the basis of a checklist described in a further report. In nine chapters, regional planning aspects, environment and landscape-relevant aspects, effects on the national and regional economies and social acceptance factors are discussed. Also, success-factors and possible solutions for the successful realisation of wind-energy projects are looked at.

Dominant region: a basic feature for group motion analysis and its application to teamwork evaluation in soccer games

Science.gov (United States)

Taki, Tsuyoshi; Hasegawa, Jun-ichi

1998-12-01

This paper proposes a basic feature for quantitative measurement and evaluation of group behavior of persons. This feature called 'dominant region' is a kind of sphere of influence for each person in the group. The dominant region is defined as a region in where the person can arrive earlier than any other persons and can be formulated as Voronoi region modified by replacing the distance function with a time function. This time function is calculated based on a computational model of moving ability of the person. As an application of the dominant region, we present a motion analysis system of soccer games. The purpose of this system is to evaluate the teamwork quantitatively based on movement of all the players in the game. From experiments using motion pictures of actual games, it is suggested that the proposed feature is useful for measurement and evaluation of group behavior in team sports. This basic feature may be applied to other team ball games, such as American football, basketball, handball and water polo.

An electrochemical approach: Switching Structures of rare earth metal Praseodymium hexacyanoferrate and its application to sulfite sensor in Red Wine

International Nuclear Information System (INIS)

Devadas, Balamurugan; Sivakumar, Mani; Chen, Shen Ming; Cheemalapati, Srikanth

2015-01-01

Graphical abstract: Nucleation and growth of PrHCF and its application to sulfite oxidation in wine samples. - Highlights: • Electrochemical synthesis of PrHCF. • Switching structures of PrHCF. • Sulfite electrochemical sensor. • Wide linear range and low limit of detection. • Real sample application. - Abstract: Herein, we report a shape-controlled preparation of Praseodymium hexacyanoferrate (PrHCF) using a simple electrochemical technique. The electrochemically fabricated PrHCF modified glassy carbon electrodes (GCE) shows an excellent electrocatalytic activity towards sulfite oxidation. The morphology of PrHCF particles were controlled by carefully changing various synthesis conditions including electrochemical technique (cyclic voltammetry, amperometry and chemical), cations in the supporting electrolyte (K + , Na + , Li + and H + ), deposition cycles, molar ratio of precursors, and applied potential (-.2,0 and 0.2 V). The morphologies of the PrHCF was elucidated using scanning electron microscopy (SEM). The as-synthesized PrHCF was characterized using X-ray diffraction pattern (XRD), Infra-red (IR) and energy dispersive X-ray spectroscopy (EDX). The electrochemical oxidation of sulfite on PrHCF modified GCE was investigated using cyclic voltammetry (CV) and linear sweep voltammetry (LSV). The sensitivity of the as-developed sulfite sensor was determined to be 0.036 μA μM −1 cm −2 . The low limit of detection was determined to be 2.15 μM. The real time application of PrHCF modified GCE was confirmed through the determination of sulfite from red wine and tap water samples

The basic helix-loop-helix region of the transcriptional repressor hairy and enhancer of split 1 is preorganized to bind DNA

NARCIS (Netherlands)

Popovic, Matija; Wienk, Hans; Coglievina, Maristella; Boelens, Rolf; Pongor, Sándor; Pintar, Alessandro

2014-01-01

Hairy and enhancer of split 1, one of the main downstream effectors in Notch signaling, is a transcriptional repressor of the basic helix-loop-helix (bHLH) family. Using nuclear magnetic resonance methods, we have determined the structure and dynamics of a recombinant protein, H1H, which includes an

Facile synthesis of cobalt hexacyanoferrate/graphene nanocomposites for high-performance supercapacitor

International Nuclear Information System (INIS)

Wang, Jian-Gan; Zhang, Zhiyong; Liu, Xingrui; Wei, Bingqing

2017-01-01

Prussian blue and its analogues are promising for energy storage devices owing to the rigid open framework, yet suffer from poor conductivity and relatively low energy density. Herein, we report a facile preparation of cobalt hexacyanoferrate/reduced graphene oxide nanocomposites (CoHCF/rGO) for supercapacitors with enhanced performance. The CoHCF nanoparticles with a size of around 50 nm are adhered onto the rGO nanosheets, which, in turn, not only prevent the agglomeration of the CoHCF nanoparticles but also provide conductive network for fast electron transport. The CoHCF/rGO nanocomposite delivers a maximum specific capacitance of 361 F g"−"1 in Na_2SO_4 aqueous electrolyte. Asymmetric supercapacitor cells are assembled by pairing up an optimized nanocomposite electrode with an activated carbon negative electrode, which exhibits a wide reversible operating voltage of 2.0 V and a high energy density of 39.6 Wh kg"−"1. The enhanced electrochemical performance of CoHCF/rGO benefits from the strong synergistic utilization of CoHCF nanoparticles and rGO nanosheets, rendering the nanocomposites a great promise for high-performance supercapacitors.

29 CFR 1620.1 - Basic applicability of the Equal Pay Act.

Science.gov (United States)

2010-07-01

... 29 Labor 4 2010-07-01 2010-07-01 false Basic applicability of the Equal Pay Act. 1620.1 Section 1620.1 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION THE EQUAL PAY ACT § 1620.1 Basic applicability of the Equal Pay Act. (a) Since the Equal Pay Act, 29 U.S.C...

A map of nuclear matrix attachment regions within the breast cancer loss-of-heterozygosity region on human chromosome 16q22.1

DEFF Research Database (Denmark)

Shaposhnikov, Sergey A.; Akopov, Sergey B.; Chernov, Igor P.

2007-01-01

There is abundant evidence that the DNA in eukaryotic cells is organized into loop domains that represent basic structural and functional units of chromatin packaging. To explore the DNA domain organization of the breast cancer loss-of-heterozygosity region on human chromosome 16q22.1, we have...... in the region are regulated and of how the structural architecture and functional organization of the DNA are related....... identified a significant portion of the scaffold/matrix attachment regions (S/MARs) within this region. Forty independent putative S/MAR elements were assigned within the 16q22.1 locus. More than 90% of these S/MARs are AT rich, with GC contents as low as 27% in 2 cases. Thirty-nine (98%) of the S...

IAEA regional basic professional training on radiation protection

International Nuclear Information System (INIS)

1998-01-01

This book contains the manuscripts of lectures of the Basic Professional Training Course on Radiation Protection which was organized and prepared on the basis of the standard syllabus put together in accordance with the recommendations of the International Basic safety standards for radiation protection against ionizing radiation and for safety of radiation sources (BSS). The course was intended to meet the educational and initial training requirements of personnel working in this field. The course is aimed at workers of a graduate level who are called on to take up position in the radiation protection field and who might someday become trainers in their home countries and institutions. Papers relevant to INIS are indexed separately

26 CFR 1.41-5A - Basic research for taxable years beginning before January 1, 1987.

Science.gov (United States)

2010-04-01

... TREASURY INCOME TAX INCOME TAXES Credits Against Tax § 1.41-5A Basic research for taxable years beginning... property under section 168(c) is transferred to a university for basic research on January 12, 1983, and is first so used by the university on March 1, 1983, then the research in which that property is used is...

Effect of a Brazilian regional basic diet on the prevalence of caries in rats

OpenAIRE

Pinheiro, J.T.; Couto, G.B.L.; Vasconcelos, M.M.V.B.; Melo, M.M.D.C.; Guedes, R.C.A.; Cordeiro, M.A.C.

2002-01-01

The aim of the present study was to determine the effect of a regional basic diet (RBD) on the prevalence of caries in the molar teeth of rats of both sexes aged 23 days. The animals were divided into six groups of 10 rats each receiving the following diets for 30 and 60 days after weaning: RBD, a cariogenic diet, and a commercial diet. The prevalence and penetration of caries in the molar teeth of the rats was then analyzed. The RBD produced caries in 37.5% of the teeth of animals fed 30 day...

Leptin is associated with exaggerated brain reward and emotion responses to food images in adolescent obesity.

Science.gov (United States)

Jastreboff, Ania M; Lacadie, Cheryl; Seo, Dongju; Kubat, Jessica; Van Name, Michelle A; Giannini, Cosimo; Savoye, Mary; Constable, R Todd; Sherwin, Robert S; Caprio, Sonia; Sinha, Rajita

2014-11-01

In the U.S., an astonishing 12.5 million children and adolescents are now obese, predisposing 17% of our nation's youth to metabolic complications of obesity, such as type 2 diabetes (T2D). Adolescent obesity has tripled over the last three decades in the setting of food advertising directed at children. Obese adults exhibit increased brain responses to food images in motivation-reward pathways. These neural alterations may be attributed to obesity-related metabolic changes, which promote food craving and high-calorie food (HCF) consumption. It is not known whether these metabolic changes affect neural responses in the adolescent brain during a crucial period for establishing healthy eating behaviors. Twenty-five obese (BMI 34.4 kg/m2, age 15.7 years) and fifteen lean (BMI 20.96 kg/m2, age 15.5 years) adolescents underwent functional MRI during exposure to HCF, low-calorie food (LCF), and nonfood (NF) visual stimuli 2 h after isocaloric meal consumption. Brain responses to HCF relative to NF cues increased in obese versus lean adolescents in striatal-limbic regions (i.e., putamen/caudate, insula, amygdala) (P < 0.05, family-wise error [FWE]), involved in motivation-reward and emotion processing. Higher endogenous leptin levels correlated with increased neural activation to HCF images in all subjects (P < 0.05, FWE). This significant association between higher circulating leptin and hyperresponsiveness of brain motivation-reward regions to HCF images suggests that dysfunctional leptin signaling may contribute to the risk of overconsumption of these foods, thus further predisposing adolescents to the development of obesity and T2D. © 2014 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered.

Label Review Training: Module 1: Label Basics, Page 29

Science.gov (United States)

This module of the pesticide label review training provides basic information about pesticides, their labeling and regulation, and the core principles of pesticide label review. This page is a quiz on Module 1.

7. International Frumkin Symposium. Basic electrochemistry for science and technology. Abstracts. Part 1

International Nuclear Information System (INIS)

2000-01-01

Modern tendencies of development of electrochemistry as in regions of fundamental investigations so in applied directions are presented. Basic themes of reports presented are: charge transport in condensed media, interface fenomena and electric properties at low soluble substances with electrolyte solutions, structure and properties of charged interfaces, transport in electrochemical systems, problems of bioelectrochemistry [ru

The Analysis of Basic Public Service Supply Regional Equalization in China’s Provinces——Based on the Theil Index Evaluation

Science.gov (United States)

Liao, Zangyi

2017-12-01

Accomplishing the regional equalization of basic public service supply among the provinces in China is an important objective that can promote the people’s livelihood construction. In order to measure the problem which is about the non-equalization of basic public service supply, this paper takes these aspects as the first index, such as the infrastructure construction, basic education services, public employment services, public health service and social security service. At the same time, it cooperates with 16 index as the second index to construct the performance evaluation systems, and then use the Theil index to evaluate the performance in provinces that using the panel data from the year 2000 to 2012.

Gibberellin-regulated gene in the basal region of rice leaf sheath encodes basic helix-loop-helix transcription factor.

Science.gov (United States)

Komatsu, Setsuko; Takasaki, Hironori

2009-07-01

Genes regulated by gibberellin (GA) during leaf sheath elongation in rice seedlings were identified using the transcriptome approach. mRNA from the basal regions of leaf sheaths treated with GA3 was analyzed by high-coverage gene expression profiling. 33,004 peaks were detected, and 30 transcripts showed significant changes in the presence of GA3. Among these, basic helix-loop-helix transcription factor (AK073385) was significantly upregulated. Quantitative PCR analysis confirmed that expression of AK073385 was controlled by GA3 in a time- and dose-dependent manner. Basic helix-loop-helix transcription factor (AK073385) is therefore involved in the regulation of gene expression by GA3.

Relative cost-effectiveness of an extensively hydrolyzed casein formula containing the probiotic Lactobacillus rhamnosus GG in managing infants with cow's milk allergy in Italy

Directory of Open Access Journals (Sweden)

Guest JF

2015-06-01

Full Text Available Julian F Guest,1,2 Monica Panca,1 Olga Ovcinnikova,1 Rita Nocerino3 1CATALYST Health Economics Consultants, Northwood, Middlesex, UK; 2Faculty of Life Sciences and Medicine, King's College, London, UK; 3Department of Translational Medical Science, Pediatric Section, University of Naples 'Federico II', Naples, Italy Objective: To estimate the cost-effectiveness of using an extensively hydrolyzed casein formula (eHCF containing the probiotic Lactobacillus rhamnosus GG, (eHCF + LGG; Nutramigen LGG as first-line management for cow's milk allergy (CMA compared with eHCF alone, soy-based formulae (SBF, hydrolyzed rice formulae (HRF, and amino acid formulae (AAF in Italy, from the perspective of the Italian National Health Service (INHS and parents. Methods: Decision modeling was used to estimate the probability of infants developing tolerance to cow's milk by 18 months, based on an observational study dataset. The model also estimated the cost (at 2012/2013 prices of health care resource use funded by the INHS and formulae paid for by parents over 18 months after starting a formula, as well as the relative cost-effectiveness of each of the formulae. Results: The probability of developing tolerance to cow's milk by 18 months was higher among infants with either IgE-mediated or non-IgE-mediated allergy who were fed eHCF + LGG compared to those fed one of the other formulae. The total health care cost of initially feeding infants with eHCF + LGG was less than that of feeding infants with one of the other formulae. Hence, eHCF + LGG affords the greatest value for money to both the INHS and parents of infants with either IgE-mediated or non-IgE-mediated CMA. Conclusion: Using eHCF + LGG instead of eHCF, SBF, HRF, or an AAF for first-line management of newly diagnosed infants with CMA in Italy affords a cost-effective use of publicly funded resources, and is cost-effective from the parents' perspective, since it improves outcome for less cost. A randomized

Basic investigation for life assessment technology of modified 9CR-1Mo steel

Energy Technology Data Exchange (ETDEWEB)

Okamura, Hiroyuki [Science Univ. of Tokyo (Japan); Ohtani, Ryuichi [Kyoto Univ. (Japan); Fujii, Kazuya [Japan Power Engineering and Inspection Corp., Tokyo (Japan); Kimura, Kazushige; Ishii, Ryuichi; Fujiyama, Kazunari; Hongo, Shigetada; Iseki, Takashi; Uchida, Hiroshi [Toshiba Corp., Kawasaki, Kanagawa (Japan)

1998-11-01

For the basic study of life assessment technologies for aged components made of mod.9Cr-1Mo steel, specimens were artificially deteriorated by aging, creep and fatigue tests at elevated temperatures. And metallurgical and mechanical properties were examined. The change in the precipitates caused the decrease in toughness. The creep damage in base metal corresponded to the decrease in hardness. The fatigue damage in base metal correlated to the maximum length of a crack among micro-cracks initiated during fatigue cycle. In the welded joint, the creep fracture occurred by the formation and growth of voids in the fine grained region of HAZ near base metal. The creep damage was associated with the increase in both number and area fraction of voids. (orig.)

34 CFR 461.1 - What is the Adult Education State-administered Basic Grant Program?

Science.gov (United States)

2010-07-01

... 34 Education 3 2010-07-01 2010-07-01 false What is the Adult Education State-administered Basic...-ADMINISTERED BASIC GRANT PROGRAM General § 461.1 What is the Adult Education State-administered Basic Grant Program? The Adult Education State-administered basic Grant Program (the program) is a cooperative effort...

Proteomic analysis of the herpes simplex virus 1 virion protein 16 transactivator protein in infected cells.

Science.gov (United States)

Suk, Hyung; Knipe, David M

2015-06-01

The herpes simplex virus 1 virion protein 16 (VP16) tegument protein forms a transactivation complex with the cellular proteins host cell factor 1 (HCF-1) and octamer-binding transcription factor 1 (Oct-1) upon entry into the host cell. VP16 has also been shown to interact with a number of virion tegument proteins and viral glycoprotein H to promote viral assembly, but no comprehensive study of the VP16 proteome has been performed at early times postinfection. We therefore performed a proteomic analysis of VP16-interacting proteins at 3 h postinfection. We confirmed the interaction of VP16 with HCF-1 and a large number of cellular Mediator complex proteins, but most surprisingly, we found that the major viral protein associating with VP16 is the infected cell protein 4 (ICP4) immediate-early (IE) transactivator protein. These results raise the potential for a new function for VP16 in associating with the IE ICP4 and playing a role in transactivation of early and late gene expression, in addition to its well-documented function in transactivation of IE gene expression. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Investigation of thermal fatigue behavior of thermal barrier coating systems

International Nuclear Information System (INIS)

Zhu Dongming; Miller, R.A.

1997-01-01

In the present study, the mechanisms of fatigue crack initiation and propagation, and of coating failure under thermal loads that simulate those in diesel engines are investigated. Surface cracks initiate early and grow continuously under thermal low cycle fatigue (LCF) and high cycle fatigue (HCF) stresses. It is found that, in the absence of interfacial oxidation, the failure associated with LCF is closely related to coating sintering and creep at high temperatures. Significant LCF and HCF interactions have been observed in the thermal fatigue tests. The fatigue crack growth rate in the ceramic coating strongly depends on the characteristic HCF cycle number, N* HCF which is defined as the number of HCF cycles per LCF cycle. The crack growth rate is increased from 0.36 μm/LCF cycle for a pure LCF test to 2.8 μm/LCF cycle for a combined LCF and HCF test at N* HCF about 20 000. A surface wedging model has been proposed to account for the HCF crack growth in the coating systems. This mechanism predicts that the HCF damage effect increases with heat flux and thus with increasing surface temperature swing, thermal expansion coefficient and elastic modulus of the ceramic coating, as well as with the HCF interacting depth. Good correlation has been found between the analysis and experimental evidence. (orig.)

Inhibition of intestinal radiocaesium absorption from Chernobyl contaminated whey by hexacyanoferrates(II) in pigs

International Nuclear Information System (INIS)

Dresow, B.; Asmus, J.; Fischer, R.; Nielsen, P.; Heinrich, H.C.

1993-01-01

The inhibition of radiocaesium transfer from Chernobyl contaminated whey powder to the pork and liver of fattening pigs using various dosages of different hexacyanoferrate (II) compounds (HCF) was studied under normal feeding conditions. Increasing amounts of all three hexacyanoferates tested resulted in a dose-dependent reduction in the 134+137 Cs activity concentration in all of the tissues sampled. KFe[Fe(CN) 6 ] and NE 4 Fe(CN) 6 ] were effective to the same extent while Fe 4 [Fe(CN) 6 ] 3 was less effective at dosages of 1-3 g d -1 HCF. Administration of 10 g d -1 HCF resulted in an almost complete inhibition (>99%) of intestinal radiocaesium absorption for all three compounds. (Author)

Basic design parameters for the new PRR-1 stack

International Nuclear Information System (INIS)

Leopando, L.S.

1994-01-01

This report presents the results of work done to establish the basic design parameters of the new stack of the Philippine Research Reactor-1 (PRR-1). The work was undertaken to assure that the radioactive air emissions of the PRR-1, under both accident and normal operating conditions, will comply with modern safety practices. The work was done during June and July 1994. (author). 6 refs., 13 figs., 13 tabs

Management of basic education for ethnic groups in highland and border regions of Thailand

Directory of Open Access Journals (Sweden)

Phathombut Keawsomnuk

2017-05-01

The research findings revealed that the actors for advocacy policy in basic education for ethnic groups consist of: 1 the primary education service area, 2 community, 3 NGOs, 4 scholars, and 5 schools. This study indicated that the provision of basic education policy for ethnic groups must consist of knowledge from communities such as ethnic life styles integrated in the curriculum, and a special education mechanism and process for Thai ethnic groups, including facilitation of ethnic group participation in the abovementioned actors by various means.

Reverse microemulsion synthesis of nickel-cobalt hexacyanoferrate/reduced graphene oxide nanocomposites for high-performance supercapacitors and sodium ion batteries

Science.gov (United States)

Qiu, Xiaoming; Liu, Yongchang; Wang, Luning; Fan, Li-Zhen

2018-03-01

Prussian blue analogues with tunable open channels are of fundamental and technological importance for energy storage systems. Herein, a novel facile synthesis of nickel-cobalt hexacyanoferrate/reduced graphene oxide (denoted as Ni-CoHCF/rGO) nanocomposite is realized by a reverse microemulsion method. The very fine Ni-CoHCF nanoparticles (10-20 nm) are homogeneously anchored on the surface of reduced graphene oxide by electrostatic adsorption and reduced graphene oxide is well-separated by Ni-CoHCF particles. Benefiting from the combined advantages of this structure, the Ni-. It CoHCF/rGO nanocomposite can be used as electrodes for both supercapacitors and sodium ion batteries exhibits excellent pseudocapacitve performance in terms of high specific capacitance of 466 F g-1 at 0.2 A g-1 and 350 F g-1 at 10 A g-1, along with high cycling stabilities. As a cathode material for sodium ion batteries, it also demonstrates a high reversible capacity of 118 mAh g-1 at 0.1 A g-1, good rate capability, and superior cycling stability. These results suggest its potential as an efficient electrode for high-performance energy storage and renewable delivery devices.

Basic Practices Aiding High-Performance Homeland Security Regional Partnerships

National Research Council Canada - National Science Library

Caudle, Sharon

2006-01-01

....1 A national priority under the Goal is the use of geographic regions across the nation to share risk, engage in joint planning, and share resources to develop and sustain risk-based capability levels...

Investigation of bending fatigue-life of aluminum sheets based on rolling direction

Directory of Open Access Journals (Sweden)

Raif Sakin

2018-03-01

Full Text Available High-cycle fatigue (HCF and low-cycle fatigue (LCF fatigue lives of rolled AA1100 and AA1050 aluminum sheets along different directions were evaluated at room temperature. Four types of samples denoted as longitudinal (L and transverse (T to the rolling direction were compared because the samples along the two typical directions show an obvious anisotropy. A cantilever plane-bending and multi-type fatigue testing machine was specially designed for this purpose. Deflection-controlled fatigue tests were conducted under fully reversed loading. The longest fatigue lives in the LCF region were obtained for AA1050 (L while AA1100 (L samples had the longest fatigue lives in the HCF region. Keywords: AA1100, AA1050, Aluminum sheet, Bending fatigue life, Rolling direction

Man's Basic Needs. Resource Units, Grade 1. Providence Social Studies Curriculum Project.

Science.gov (United States)

Providence Public Schools, RI.

GRADES OR AGES: Grade 1. SUBJECT MATTER: Social studies; man's basic needs. ORGANIZATION AND PHYSICAL APPEARANCE: The guide is divided into 11 chapters, five of which outline the basic curriculum subunits. These five chapters are laid out in three columns, one each for topics, activities, and materials. Other chapters are in list form. The guide…

Boron isotope sensitivity to seawater pH change in a species of Neogoniolithon coralline red alga

Science.gov (United States)

Donald, Hannah K.; Ries, Justin B.; Stewart, Joseph A.; Fowell, Sara E.; Foster, Gavin L.

2017-11-01

The increase in atmospheric carbon dioxide (CO2) observed since the industrial revolution has reduced surface ocean pH by ∼0.1 pH units, with further change in the oceanic system predicted in the coming decades. Calcareous organisms can be negatively affected by extreme changes in seawater pH (pHsw) such as this due to the associated changes in the oceanic carbonate system. The boron isotopic composition (δ11B) of biogenic carbonates has been previously used to monitor pH at the calcification site (pHcf) in scleractinian corals, providing mechanistic insights into coral biomineralisation and the impact of variable pHsw on this process. Motivated by these investigations, this study examines the δ11B of the high-Mg calcite skeleton of the coralline red alga Neogoniolithon sp. to constrain pHcf, and investigates how this taxon's pHcf is impacted by ocean acidification. δ11B was measured in multiple algal replicates (n = 4-5) cultured at four different pCO2 scenarios - averaging (±1σ) 409 (±6), 606 (±7), 903 (±12) and 2856 (±54) μatm, corresponding to average pHsw (±1σ) of 8.19 (±0.03), 8.05 (±0.06), 7.91 (±0.03) and 7.49 (±0.02) respectively. Results show that skeletal δ11B is elevated relative to the δ11B of seawater borate at all pHsw treatments by up to 18‰. Although substantial variability in δ11B exists between replicate samples cultured at a given pHsw (smallest range = 2.32‰ at pHsw 8.19, largest range = 6.08‰ at pHsw 7.91), strong correlations are identified between δ11B and pHsw (R2 = 0.72, p < 0.0001, n = 16) and between δ11B and B/Ca (R2 = 0.72, p < 0.0001, n = 16). Assuming that skeletal δ11B reflects pHcf as previously observed for scleractinian corals, the average pHcf across all experiments was 1.20 pH units (0.79 to 1.56) higher than pHsw, with the magnitude of this offset varying parabolically with decreasing pHsw, with a maximum difference between pHsw and pHcf at a pHsw of 7.91. Observed relationships between pHsw and

N-terminal segments modulate the α-helical propensities of the intrinsically disordered basic regions of bZIP proteins.

Science.gov (United States)

Das, Rahul K; Crick, Scott L; Pappu, Rohit V

2012-02-17

Basic region leucine zippers (bZIPs) are modular transcription factors that play key roles in eukaryotic gene regulation. The basic regions of bZIPs (bZIP-bRs) are necessary and sufficient for DNA binding and specificity. Bioinformatic predictions and spectroscopic studies suggest that unbound monomeric bZIP-bRs are uniformly disordered as isolated domains. Here, we test this assumption through a comparative characterization of conformational ensembles for 15 different bZIP-bRs using a combination of atomistic simulations and circular dichroism measurements. We find that bZIP-bRs have quantifiable preferences for α-helical conformations in their unbound monomeric forms. This helicity varies from one bZIP-bR to another despite a significant sequence similarity of the DNA binding motifs (DBMs). Our analysis reveals that intramolecular interactions between DBMs and eight-residue segments directly N-terminal to DBMs are the primary modulators of bZIP-bR helicities. We test the accuracy of this inference by designing chimeras of bZIP-bRs to have either increased or decreased overall helicities. Our results yield quantitative insights regarding the relationship between sequence and the degree of intrinsic disorder within bZIP-bRs, and might have general implications for other intrinsically disordered proteins. Understanding how natural sequence variations lead to modulation of disorder is likely to be important for understanding the evolution of specificity in molecular recognition through intrinsically disordered regions (IDRs). Copyright © 2011 Elsevier Ltd. All rights reserved.

Coral calcifying fluid pH dictates response to ocean acidification.

Science.gov (United States)

Holcomb, M; Venn, A A; Tambutté, E; Tambutté, S; Allemand, D; Trotter, J; McCulloch, M

2014-06-06

Ocean acidification driven by rising levels of CO2 impairs calcification, threatening coral reef growth. Predicting how corals respond to CO2 requires a better understanding of how calcification is controlled. Here we show how spatial variations in the pH of the internal calcifying fluid (pHcf) in coral (Stylophora pistillata) colonies correlates with differential sensitivity of calcification to acidification. Coral apexes had the highest pHcf and experienced the smallest changes in pHcf in response to acidification. Lateral growth was associated with lower pHcf and greater changes with acidification. Calcification showed a pattern similar to pHcf, with lateral growth being more strongly affected by acidification than apical. Regulation of pHcf is therefore spatially variable within a coral and critical to determining the sensitivity of calcification to ocean acidification.

Solar heating. Vol. 1. Basic knowledge of thermal science

Energy Technology Data Exchange (ETDEWEB)

Jauffret, C.

1982-01-01

This document deals with general basic knowledge of thermal sciences: basics of thermodynamics, heat transfer, studies of thermal exchanges in the building industry including ventilation and the effects of the wind, basics and techniques of central heating and refrigeration (technologies, calculations, thermodynamic cycles and refrigerating machines).

Conceptual Approach to Forming the Basic Code of Neo-Industrial Development of a Region

Directory of Open Access Journals (Sweden)

Elena Leonidovna Andreeva

2017-09-01

Full Text Available In the article, the authors propose the conceptual fundamentals of the “code approach” to the regional neo-industrial development. The purpose of the research is to reveal the essence of the transition to a new type of industrial and economic relations through a prism of “genetic codes” of the region. We consider these codes as a system of the “racial memory” of a territory, which determines the specificity and features of neo-industrialization realization. We substantiated the hypothesis about the influence of the “genetic codes” of the region on the effectiveness of the neo-industrialization. We have defined the participants, or else the carriers of the codes in the transformation of regional inheritance for the stimulation of the neoindustrial development of region’s economy. The subject matter of the research is the distinctive features of the functioning of the determinative region’s codes. Their content determines the socio-economic specificity of the region and the features of innovative, informational, value-based and competence-based development of the territory. The determinative codes generate the dynamic codes of the region, which are understood as their derivatives. They have a high probability of occurrence, higher speed of development and distribution, internal forces that make possible the self-development of the region. The scientific contribution is the substantiation of the basic code of the regional neo-industrial development. It represents the evolutionary accumulation of the rapid changes of its innovative, informational, value-based and competence-based codes stimulating the generation and implementation of new ideas regarding to economic entities adapted to the historical and cultural conditions. The article presents the code model of neo-industrial development of the region described by formulas. We applied the system analysis methods, historical and civilization approaches, evolutionary and

Regional and Interregional Cooperation to Strengthen Basic Sciences in Developing Countries : Addis Ababa, 1-4 September 2009

OpenAIRE

2011-01-01

The International Science Programme (ISP) at Uppsala University, Sweden, is devoted to long-term support to institutional capacity building in research and higher education in developing countries, with focus on the basic sciences: physics (since 1961), chemistry (since 1970), and mathematics (since 2002). Both research groups and scientific network activities are supported. Interdisciplinary and applied research is important in solving a number of challenges facing the world today. Problems ...

Wind power installations in Switzerland - Regional planning basics and impact; Eoliennes en Suisse. Bases de planification pour l'amenagement du territoire et effets. Rapport de base

Energy Technology Data Exchange (ETDEWEB)

Ott, W.; Kaufmann, Y.; Steiner, P. [Econcept AG, Zuerich (Switzerland); Gilgen, K.; Sartoris, A. [IRAP-HSR, Institut fuer Raumentwicklung an der Hochschule fuer Technik Rapperswil, Rapperswil (Switzerland)

2008-07-01

This report published by the Swiss Federal Office of Energy (SFOE) takes a look at the basics of regional planning and its impact on the construction of wind-energy installations in Switzerland. The authors state that the planning and realisation of wind turbine installations is often time and resource consuming: this document presents and discusses the results obtained in a project that aimed to supply consolidated knowledge on project-relevant basics and their effect with respect to wind-energy installations. Experience gained in Switzerland and in other countries is discussed. This report on the basics of wind-energy planning with its detailed information formed the basis of a checklist described in a further report. In nine chapters, regional planning aspects, environment and landscape-relevant aspects, effects on the national and regional economies and social acceptance factors are discussed. Also, success-factors and possible solutions for the successful realisation of wind-energy projects are looked at.

Notes on basic materials (1)

International Nuclear Information System (INIS)

Donald, R.

1976-01-01

This lecture was a revision of basic material, intended for students who were mainly postgraduate at the end of their first year in experimental high energy physics. The subject headings include the following: notation and generalities; classification of particles; symmetry arguments; higher symmetries; SU 3 isoscalar factors; predictions from SU 3; charm; relativistic wave equations; Feynman graphical techniques. (U.K.)

The Use of Wetting Agents/Fume Supressants for Minimizing the Atmospheric Emissions from Hard Chromium Electroplating Baths

Science.gov (United States)

2003-08-01

Accreditation (A2LA) for compliance with ISO 9001, Quality Systems - Model for Quality Assurance in Design, Development, Production, Installation and Servicing...All samples handling and testing at Patuxent River laboratory is ISO 9001 compliant. Appendix D, Table 1, 2, and 4 outline the test methods...HCF 0.1 4 3 8583 ± 288 8257/8909 8155/9012 1 TEST (N = 44090 CYCLES) TREATED AS AN OUTLIER. EXTRA HARD CHROME WITH FUME SUPPRESSANT HCF -1 4 4

Regional alternative transportation evaluation report - region 1

Science.gov (United States)

2011-01-21

The U.S. Fish and Wildlife Service (FWS) and the U.S. Department of Transportation (DOT) Volpe Center (Volpe Center) conducted a regional alternative transportation evaluation (RATE) in Region 1, which is comprised of Oregon, Idaho, Washington, and H...

Rotor-generated unsteady aerodynamic interactions in a 1½ stage compressor

Science.gov (United States)

Papalia, John J.

Because High Cycle Fatigue (HCF) remains the predominant surprise failure mode in gas turbine engines, HCF avoidance design systems are utilized to identify possible failures early in the engine development process. A key requirement of these analyses is accurate determination of the aerodynamic forcing function and corresponding airfoil unsteady response. The current study expands the limited experimental database of blade row interactions necessary for calibration of predictive HCF analyses, with transonic axial-flow compressors of particular interest due to the presence of rotor leading edge shocks. The majority of HCF failures in aircraft engines occur at off-design operating conditions. Therefore, experiments focused on rotor-IGV interactions at off-design are conducted in the Purdue Transonic Research Compressor. The rotor-generated IGV unsteady aerodynamics are quantified when the IGV reset angle causes the vane trailing edge to be nearly aligned with the rotor leading edge shocks. A significant vane response to the impulsive static pressure perturbation associated with a shock is evident in the point measurements at 90% span, with details of this complex interaction revealed in the corresponding time-variant vane-to-vane flow field data. Industry wide implementation of Controlled Diffusion Airfoils (CDA) in modern compressors motivated an investigation of upstream propagating CDA rotor-generated forcing functions. Whole field velocity measurements in the reconfigured Purdue Transonic Research Compressor along the design speedline reveal steady loading had a considerable effect on the rotor shock structure. A detached rotor leading edge shock exists at low loading, with an attached leading edge and mid-chord suction surface normal shock present at nominal loading. These CDA forcing functions are 3--4 times smaller than those generated by the baseline NACA 65 rotor at their respective operating points. However, the IGV unsteady aerodynamic response to the CDA

In Situ Synthesis of Mn3 O4 Nanoparticles on Hollow Carbon Nanofiber as High-Performance Lithium-Ion Battery Anode.

Science.gov (United States)

Zhang, Dan; Li, Guangshe; Fan, Jianming; Li, Baoyun; Li, Liping

2018-04-26

The practical applications of Mn 3 O 4 in lithium-ion batteries are greatly hindered by fast capacity decay and poor rate performance as a result of significant volume changes and low electrical conductivity. It is believed that the synthesis of nanoscale Mn 3 O 4 combined with carbonaceous matrix will lead to a better electrochemical performance. Herein, a convenient route for the synthesis of Mn 3 O 4 nanoparticles grown in situ on hollow carbon nanofiber (denoted as HCF/Mn 3 O 4 ) is reported. The small size of Mn 3 O 4 particles combined with HCF can significantly alleviate volume changes and electrical conductivity; the strong chemical interactions between HCF and Mn 3 O 4 would improve the reversibility of the conversion reaction for MnO into Mn 3 O 4 and accelerate charge transfer. These features endow the HCF/Mn 3 O 4 composite with superior cycling stability and rate performance if used as the anode for lithium-ion batteries. The composite delivers a high discharge capacity of 835 mA h g -1 after 100 cycles at 200 mA g -1 , and 652 mA h g -1 after 240 cycles at 1000 mA g -1 . Even at 2000 mA g -1 , it still shows a high capacity of 528 mA h g -1 . The facile synthetic method and outstanding electrochemical performance of the as-prepared HCF/Mn 3 O 4 composite make it a promising candidate for a potential anode material for lithium-ion batteries. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Importance of basic CPR techniques. A study in the Region of Murcia

Directory of Open Access Journals (Sweden)

J. Arturo Abraldes Valeiras

2011-01-01

Full Text Available Annually in Spain many people die from diseases related to heart. Heart attack is the main cause of such deaths. Know and control the basic techniques of basic Cardiopulmonary resuscitation (CPR are essential to help a person away from these features. This study examined 1 the importance of knowing these techniques in the general population, and 2 the perception of the difficulty of understanding and application of techniques. We used a questionnaire designed "ad hoc" as a tool for collecting information. The instrument was subjected to validation and reliability for the study. The questionnaire was completed by 235 volunteers aged between 10 and 65. We performed a descriptive analysis, based on gender and the variables importance of knowledge and learning / apply techniques. Among the most relevant results, we emphasize an interest of society to improve training in this type of knowledge. Training would be ideal in most age groups of people (teens to seniors. Likewise, CPR techniques are easy to understand and execute a lesser extent, relevant perception among people who acknowledge and application these techniques

Basic electrotechnology

CERN Document Server

Ashen, R A

2013-01-01

BASIC Electrotechnology discusses the applications of Beginner's All-purpose Symbolic Instruction Code (BASIC) in engineering, particularly in solving electrotechnology-related problems. The book is comprised of six chapters that cover several topics relevant to BASIC and electrotechnology. Chapter 1 provides an introduction to BASIC, and Chapter 2 talks about the use of complex numbers in a.c. circuit analysis. Chapter 3 covers linear circuit analysis with d.c. and sinusoidal a.c. supplies. The book also discusses the elementary magnetic circuit theory. The theory and performance of two windi

A basic peptide within the juxtamembrane region is required for EGF receptor dimerization.

Science.gov (United States)

Aifa, Sami; Aydin, Jan; Nordvall, Gunnar; Lundström, Ingemar; Svensson, Samuel P S; Hermanson, Ola

2005-01-01

The epidermal growth factor receptor (EGFR) is fundamental for normal cell growth and organ development, but has also been implicated in various pathologies, notably tumors of epithelial origin. We have previously shown that the initial 13 amino acids (P13) within the intracellular juxtamembrane region (R645-R657) are involved in the interaction with calmodulin, thus indicating an important role for this region in EGFR function. Here we show that P13 is required for proper dimerization of the receptor. We expressed either the intracellular domain of EGFR (TKJM) or the intracellular domain lacking P13 (DeltaTKJM) in COS-7 cells that express endogenous EGFR. Only TKJM was immunoprecipitated with an antibody directed against the extracellular part of EGFR, and only TKJM was tyrosine phosphorylated by endogenous EGFR. Using SK-N-MC cells, which do not express endogenous EGFR, that were stably transfected with either wild-type EGFR or recombinant full-length EGFR lacking P13 demonstrated that P13 is required for appropriate receptor dimerization. Furthermore, mutant EGFR lacking P13 failed to be autophosphorylated. P13 is rich in basic amino acids and in silico modeling of the EGFR in conjunction with our results suggests a novel role for the juxtamembrane domain (JM) of EGFR in mediating intracellular dimerization and thus receptor kinase activation and function.

Immunological comparison of basic encephalitogen and histone F2A1

International Nuclear Information System (INIS)

Bustin, M.; Teitelbaum, D.; Webb, C.

1975-01-01

The extent of immunological cross-reaction between basic encephalitogen and histone F2A1 on both the humoral antibody level and on the cellular level has been established. The extent of humoral cross-reaction was tested by direct complement fixation employing both anti-histone F2A1 and antisera to basic encephalitogen, by inhibition of complement fixation, by radioimmunoassay and by passive cutaneous anaphylaxis. The data obtained failed to reveal immunological cross-reaction between the proteins on the humoral antibody level. The extent of cross-reaction at the cellular level was tested by the lymphocyte stimulation technique in rabbits and guinea pigs, by inhibition of lymphocyte stimulation and by delayed hypersensitivity skin reactions. It is concluded that the immunological studies provide limited evidence that the two proteins share antigenic determinants. (orig./GSE) [de

Basic rocks in Finland

International Nuclear Information System (INIS)

Piirainen, T.; Gehoer, S.; Iljina, M.; Kaerki, A.; Paakkola, J.; Vuollo, J.

1992-10-01

Basic igneous rocks, containing less than 52% SiO 2 , constitute an important part of the Finnish Archaean and Proterozoic crust. In the Archaean crust exist two units which contain the majority of the basic rocks. The Arcaean basic rocks are metavolcanics and situated in the Greenstone Belts of Eastern Finland. They are divided into two units. The greenstones of the lower one are tholeiites, komatiites and basaltic komatiites. The upper consists of bimodal series of volcanics and the basic rocks of which are Fe-tholeiites, basaltic komatiites and komatiites. Proterozoic basic rocks are divided into seven groups according to their ages. The Proterozoic igneous activity started by the volominous basic magmatism 2.44 Ga ago. During this stage formed the layered intrusions and related dykes in the Northern Finland. 2.2 Ga old basic rocks are situated at the margins of Karelian formations. 2.1 Ga aged Fe-tholeiitic magmatic activity is widespread in Eastern and Northern Finland. The basic rocks of 1.97 Ga age group are met within the Karelian Schist Belts as obducted ophiolite complexes but they occur also as tholeiitic diabase dykes cutting the Karelian schists and Archean basement. The intrusions and the volcanics of the 1.9 Ga old basic igneous activity are mostly encountered around the Granitoid Complex of Central Finland. Subjotnian, 1.6 Ga aged tholeiitic diabases are situated around the Rapakivi massifs of Southern Finland, and postjotnian, 1.2 Ga diabases in Western Finland where they form dykes cutting Svecofennian rocks

Gamma Radiation -Induced Preparation of Polymeric Composite Resins and their Structure Assignments

International Nuclear Information System (INIS)

El-Zahhar, A.A.; Abdel-Aziz, H.M.; Siyam, T.

2005-01-01

Poly(acrylamide-acrylic acid). ethylenediamine tetra acetic acid disodium salt P(AM-AA). EDTANa2, Poly(acrylamide-acrylic acid)montmorillonite P(AM-AA). montmorillonite, and Poly(acrylamide acrylic acid)-potassium nickel hexacyanoferrate P(AM-AA)-KNiHCF were prepared by gamma radiation- induced template polymerization of (AA) on P(AM) as a template polymer in the presence of EDTANa2, Clay(montmorillonite), KNiHCF and KZnHCF, respectively. The capacity of the prepared P (AM-AA)-EDTANa2 and P (AM-AA)-montmorillonite composites increases with increasing of EDTANa2 and montmorillonite concentration then decreases. While the capacity of P(AM- AA). KNiHCF composites increases with increasing of KNiHCF content. The characteristic properties of prepared polymeric composites resins were studied by using FTIR spectroscopy

Electrochemical Removal of Radioactive Cesium from Nuclear Waste Using the Dendritic Copper Hexacyanoferrate/Carbon Nanotube Hybrids

International Nuclear Information System (INIS)

Zheng, Yuanyuan; Qiao, Junhua; Yuan, Junhua; Shen, Jianfeng; Wang, Ai-jun; Niu, Li

2017-01-01

Highlights: •Copper hexacyanoferrate was uniformly covered on carbon nanotubes. •Cs + ion can be exchanged using this hybrid by controlling the electrode potential. •The maximum of Cs + adsorption capacity is 310 mg·g −1 in 50 μM Cs + solution. •The distribution coefficient of Cs + in this hybrid reaches up to 568 L·g −1 ,. •This hybrid can be regenerated with high stability for Cs + exchange. -- Abstract: A novel electrochemical separation system was developed based on copper hexacyanoferrate/multiwalled carbon nanotube (CuHCF/MWCNT) hybrids for selectively removing cesium from wastewater. These CuHCF/MWCNT hybrids were prepared by co-precipitation strategy. The as-prepared CuHCF nanoparticles were uniformly covered on MWCNTs to form a dendritic core-shell structure. This novel structure can improve CuHCFs conductivity, making CuHCFs more accessible for ion exchange. The uptake and release of alkali ion in CuHCF/MWCNT hybrids can be shifted mutually by switching the applied potentials between the anode and cathode. This ion exchange is a fast and reversible process associated with electron transfer in CuHCFs. The potential response depends on the radius of alkali ion. Using this electrochemical adsorption system (EAS), the maximum adsorption capacity (Q max ) of Cs + ion for CuHCFs/MWCNT hybrids reaches up to 310 mg·g −1 in 50 μM Cs + solution with a distribution coefficient K d of 568 L·g −1 , superior to the Cs + removal performance by the conventional adsorption system (Q max 230 mg·g −1 , Kd 389 L·g −1 ). Besides, CuHCF/MWCNT hybrids can be regenerated electrochemically. In addition to the advantages in Cs + removal performance and electrochemical regenerability, they can maintain considerable stability with uptake capacity retention of 85% after 100 cycles of adsorption and regeneration.

Have Basic Mathematical Skills Grown Obsolete in the Computer Age: Assessing Basic Mathematical Skills and Forecasting Performance in a Business Statistics Course

Science.gov (United States)

Noser, Thomas C.; Tanner, John R.; Shah, Situl

2008-01-01

The purpose of this study was to measure the comprehension of basic mathematical skills of students enrolled in statistics classes at a large regional university, and to determine if the scores earned on a basic math skills test are useful in forecasting student performance in these statistics classes, and to determine if students' basic math…

20 CFR 638.502 - Job Corps basic education program.

Science.gov (United States)

2010-04-01

... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Job Corps basic education program. 638.502... education program. The Job Corps Director shall prescribe or provide for basic education curricula to be... coordination with regional offices, shall review and approve the basic education program at each center. Center...

The basic and ultrabasic dikes from the coast region between the Sao Sebastiao and Ubatuba cities, Sao Paulo State, SP, Brazil

International Nuclear Information System (INIS)

Garda, Gianna Maria

1995-01-01

The coastline between Sao Sebastiao and Ubatuba cities and the shores of Sao Sebastiao, Anchieta and Mar Virado islands (Sao Paulo State, Brazil) are crosscut by several small swarms and isolated dykes trending N55E. The main rock types range from basic to intermediate, but also a conspicuous variety of alkaline lamprophyres occur side by side with the main group. The thickness of the basic to intermediate dykes vary widely, from a few centimeters to several metres, while the lamprophyres are a few tens of centimeters thick. The objective of this thesis is the petrographic, mineralogic, petrochemical and isotopic characterization of the basic and ultrabasic dykes that occur between the Sao Sebastiao and Ubatuba cities (State of Sao Paulo), also including some occurrences from the Sao Sebastiao, Mar Virado and Anchieta islands and from the Bairro Alto region (Folha de Natividade da Serra). The petrogenetic model presented is based in the national and international bibliography. (author)

High cycle fatigue of austenitic stainless steels

International Nuclear Information System (INIS)

Gauthier, J.P.; Lehmann, D.; Picker

1990-01-01

This study concerns the evaluation of material data to be used in LMFBR design codes. High cycle fatigue properties of three austenitic stainless steels are evaluated: type AISI 316 (UKAEA tests), type AISI 316L (CEA tests) and type AISI 304 (Interatom tests). The data on these steels comprised some 550 data points from 14 casts. This data set covered a wide range of testing parameters: temperature from 20-625 0 C, frequency from 1-20 000 Hz, constant amplitude and random fatigue loading, with and without mean stress, etc. However, the testing conditions chosen by the three partners differed considerably because they had been fixed independently and not harmonized prior to the tests. This created considerable difficulties for the evaluations. Experimental procedures and statistical treatments used for the three subsets of data are described and discussed. Results are presented in tables and graphs. Although it is often difficult to single out the influence of each parameter due to the different testing conditions, several interesting conclusions can be drawn: The HCF properties of the three steels are consistent with the 0.2% proof stress, the fatigue limit being larger than the latter at temperatures above 550 0 C. The type 304 steel has lower tensile properties than the two other steels and hence also lower HCF properties. Parameters which clearly have a significant effect of HCF behaviour are mean stress or R-ratio (less in the non-endurance region than in the endurance region), temperature, cast or product. Other parameters have probably a weak or no effect but it is difficult to conclude due to insufficient data: environment, specimen orientation, frequency, specimen geometry

Three dimensional considerations in thermal-hydraulics of helical cruciform fuel rods for LWR power uprates

Energy Technology Data Exchange (ETDEWEB)

Shirvan, Koroush, E-mail: kshirvan@mit.edu; Kazimi, Mujid S.

2014-04-01

Highlights: • We benchmarked the 4 × 4 helical cruciform fuel (HCF) bundle pressure drop experimental data with CFD. • We also benchmarked the 4 × 4 HCF mixing experimental data with CFD. • We derived new friction factors for PWR and BWR designs at PWR and BWR operating conditions from CFD. • We showed the importance of modeling the 3D conduction in HCF in steady state and transient conditions. - Abstract: In order to increase the power density of current and new light water reactor designs, the helical cruciform fuel (HCF) rods have been proposed. The HCF rod is equivalent to a thin cylindrical rod, with 4 fuel containing vanes, wrapped around it. The HCF rods increase the surface area to volume ratio of the fuel and enhance the inter-subchannel mixing due to their helical shape. The rods do not need supporting grids, as they are packed to periodically contact their neighbors along the flow direction, enabling a higher power density in the core. The HCF rods were reported to have the potential to uprate existing PWRs by 45% and BWRs by 20%. In order to quantify the mixing behavior of the HCF rods based on their twist pitch, experiments were previously performed at atmospheric pressures with single phase water in a 4 by 4 HCF and cylindrical rod bundles. In this paper, the experimental results on pressure drop and mixing are benchmarked with computational fluid dynamic (CFD) using steady state the Reynolds average Navier–Stokes (RANS) turbulence model. The sensitivity of the CFD approach to computational domain, mesh size, mesh shape and RANS turbulence models are examined against the experimental conditions. Due to the refined radial velocity profile from the HCF rods twist, the turbulence models showed little sensitivity to the domain. Based on the CFD simulations, the total pressure drops under the PWR and BWR conditions are expected to be about 10% higher than the values previously reported solely from an empirical correlation based on the

Metabolic and cardiac changes in high cholesterol-fructose-fed rats

DEFF Research Database (Denmark)

Axelsen, Lene N; Pedersen, Henrik D; Petersen, Jørgen S

2010-01-01

Introduction: High cholesterol-fructose (HCF) fed rats have previously been described as an animal model of impaired cardiac insulin signaling and decreased contractile performance. In this study, we evaluated the metabolic and cardiac effects of a HCF diet in rats. Methods: Male Sprague-Dawley r......Introduction: High cholesterol-fructose (HCF) fed rats have previously been described as an animal model of impaired cardiac insulin signaling and decreased contractile performance. In this study, we evaluated the metabolic and cardiac effects of a HCF diet in rats. Methods: Male Sprague...

Non-basic amino acids in the ROMK1 channels via an appropriate distance modulate PIP2 regulated pHi-gating.

Science.gov (United States)

Lee, Chien-Hsing; Huang, Po-Tsang; Liou, Horng-Huei; Lin, Mei-Ying; Lou, Kuo-Long; Chen, Chung-Yi

2016-04-22

The ROMK1 (Kir1.1) channel activity is predominantly regulated by intracellular pH (pHi) and phosphatidylinositol 4,5-bisphosphate (PIP2). Although several residues were reported to be involved in the regulation of pHi associated with PIP2 interaction, the detailed molecular mechanism remains unclear. We perform experiments in ROMK1 pHi-gating with electrophysiology combined with mutational and structural analysis. In the present study, non basic residues of C-terminal region (S219, N215, I192, L216 and L220) in ROMK1 channels have been found to mediate channel-PIP2 interaction and pHi gating. Further, our structural results show these residues with an appropriate distance to interact with membrane PIP2. Meanwhile, a cluster of basic residues (R188, R217 and K218), which was previously discovered regarding the interaction with PIP2, exists in this appropriate distance to discriminate the regulation of channel-PIP2 interaction and pHi-gating. This appropriate distance can be observed with high conservation in the Kir channel family. Our results provide insight that an appropriate distance cooperates with the electrostatics interaction of channel-PIP2 to regulate pHi-gating. Copyright © 2016 Elsevier Inc. All rights reserved.

Functional analysis of the C-terminal region of human adenovirus E1A reveals a misidentified nuclear localization signal

International Nuclear Information System (INIS)

Cohen, Michael J.; King, Cason R.; Dikeakos, Jimmy D.; Mymryk, Joe S.

2014-01-01

The immortalizing function of the human adenovirus 5 E1A oncoprotein requires efficient localization to the nucleus. In 1987, a consensus monopartite nuclear localization sequence (NLS) was identified at the C-terminus of E1A. Since that time, various experiments have suggested that other regions of E1A influence nuclear import. In addition, a novel bipartite NLS was recently predicted at the C-terminal region of E1A in silico. In this study, we used immunofluorescence microscopy and co-immunoprecipitation analysis with importin-α to verify that full nuclear localization of E1A requires the well characterized NLS spanning residues 285–289, as well as a second basic patch situated between residues 258 and 263 ( 258 RVGGRRQAVECIEDLLNEPGQPLDLSCKRPRP 289 ). Thus, the originally described NLS located at the C-terminus of E1A is actually a bipartite signal, which had been misidentified in the existing literature as a monopartite signal, altering our understanding of one of the oldest documented NLSs. - Highlights: • Human adenovirus E1A is localized to the nucleus. • The C-terminus of E1A contains a bipartite nuclear localization signal (NLS). • This signal was previously misidentified to be a monopartite NLS. • Key basic amino acid residues within this sequence are highly conserved

Statistics for nuclear engineers and scientists. Part 1. Basic statistical inference

Energy Technology Data Exchange (ETDEWEB)

Beggs, W.J.

1981-02-01

This report is intended for the use of engineers and scientists working in the nuclear industry, especially at the Bettis Atomic Power Laboratory. It serves as the basis for several Bettis in-house statistics courses. The objectives of the report are to introduce the reader to the language and concepts of statistics and to provide a basic set of techniques to apply to problems of the collection and analysis of data. Part 1 covers subjects of basic inference. The subjects include: descriptive statistics; probability; simple inference for normally distributed populations, and for non-normal populations as well; comparison of two populations; the analysis of variance; quality control procedures; and linear regression analysis.

Genome-wide identification of basic helix-loop-helix and NF-1 motifs underlying GR binding sites in male rat hippocampus

DEFF Research Database (Denmark)

Pooley, John R.; Flynn, Ben P.; Grøntved, Lars

2017-01-01

linked to structural and organizational roles, an absence of major tethering partners for GRs, and little or no evidence for binding at negative glucocorticoid response elements. A basic helix-loop-helix motif closely resembling a NeuroD1 or Olig2 binding site was found underlying a subset of GR binding......Glucocorticoids regulate hippocampal function in part by modulating gene expression through the glucocorticoid receptor (GR). GR binding is highly cell type specific, directed to accessible chromatin regions established during tissue differentiation. Distinct classes of GR binding sites...

Electrochemical synthesis of nickel hexacyanoferrate nanoarrays with dots, rods and nanotubes morphology using a porous alumina template

Energy Technology Data Exchange (ETDEWEB)

Sabzi, Reza Emamali [Department of Chemistry, Faculty of Science, Urmia University, Urmia (Iran, Islamic Republic of); Kant, Krishna [University of South Australia, Ian Wark Research Institute, Mawson Lakes Campus, Mawson Lakes, Adelaide, SA 5095 (Australia); Losic, Dusan, E-mail: dusan.losic@unisa.edu.a [University of South Australia, Ian Wark Research Institute, Mawson Lakes Campus, Mawson Lakes, Adelaide, SA 5095 (Australia)

2010-02-01

Transition metal hexacyanoferrate (MeHCF) have attracted extensive attention because of their outstanding properties including, electrocatalysis, molecular magnetism, biosensing and ion-exchange. This paper describes an approach for fabrication of ordered nanoarrays of Ni hexacyanoferrate (NiHCF) structures with different morphologies such as dots, rods and tubes in order to advance their properties and applications. The method is based on the conversion of Ni into NiHCF nanostructures by electrochemical oxidation in the presence of hexacyanoferrate ions, using nanoporous anodic alumina oxide (AAO) as a template. The structure and morphology of formed Ni and NiHCF nanoarrays were confirmed by scanning electron microscopy (SEM), showing agreement with the pore structures of the AAO template. The electrocatalytic activity of NiHCF nanorod array electrodes showed high catalytic properties for the detection of hydrogen peroxide and the potential to be used as a platform for direct biosensing applications. The ion-exchange ability of fabricated NiHCF nanostructures (nanorods and nanotubes) toward alkali cations such as Na{sup +} has been successfully confirmed.

Electrochemical synthesis of nickel hexacyanoferrate nanoarrays with dots, rods and nanotubes morphology using a porous alumina template

International Nuclear Information System (INIS)

Sabzi, Reza Emamali; Kant, Krishna; Losic, Dusan

2010-01-01

Transition metal hexacyanoferrate (MeHCF) have attracted extensive attention because of their outstanding properties including, electrocatalysis, molecular magnetism, biosensing and ion-exchange. This paper describes an approach for fabrication of ordered nanoarrays of Ni hexacyanoferrate (NiHCF) structures with different morphologies such as dots, rods and tubes in order to advance their properties and applications. The method is based on the conversion of Ni into NiHCF nanostructures by electrochemical oxidation in the presence of hexacyanoferrate ions, using nanoporous anodic alumina oxide (AAO) as a template. The structure and morphology of formed Ni and NiHCF nanoarrays were confirmed by scanning electron microscopy (SEM), showing agreement with the pore structures of the AAO template. The electrocatalytic activity of NiHCF nanorod array electrodes showed high catalytic properties for the detection of hydrogen peroxide and the potential to be used as a platform for direct biosensing applications. The ion-exchange ability of fabricated NiHCF nanostructures (nanorods and nanotubes) toward alkali cations such as Na + has been successfully confirmed.

The cost of uncomplicated childhood fevers to Kenyan households: implications for reaching international access targets

Directory of Open Access Journals (Sweden)

Noor Abdisalan M

2006-12-01

Full Text Available Abstract Background Fever is the clinical hallmark of malaria disease. The Roll Back Malaria (RBM movement promotes prompt, effective treatment of childhood fevers as a key component to achieving its optimistic mortality reduction goals by 2010. A neglected concern is how communities will access these new medicines promptly and the costs to poor households when they are located in rural areas distant to health services. Methods We assemble data developed between 2001 and 2002 in Kenya to describe treatment choices made by rural households to treat a child's fever and the related costs to households. Using a cost-of-illness approach, we estimate the expected cost of a childhood fever to Kenyan households in 2002. We develop two scenarios to explore how expected costs to households would change if more children were treated at a health care facility with an effective antimalarial within 48 hours of fever onset. Results 30% of uncomplicated fevers were managed at home with modern medicines, 38% were taken to a health care facility (HCF, and 32% were managed at home without the use of modern medicines. Direct household cash expenditures were estimated at $0.44 per fever, while the total expected cost to households (cash and time of an uncomplicated childhood fever is estimated to be $1.91. An estimated mean of 1.42 days of caretaker time devoted to each fever accounts for the majority of household costs of managing fevers. The aggregate cost to Kenyan households of managing uncomplicated childhood fevers was at least $96 million in 2002, equivalent to 1.00% of the Kenyan GDP. Fewer than 8% of all fevers were treated with an antimalarial drug within 24 hours of fever onset, while 17.5% were treated within 48 hours at a HCF. To achieve an increase from 17.5% to 33% of fevers treated with an antimalarial drug within 48 hours at a HCF (Scenario 1, children already being taken to a HCF would need to be taken earlier. Under this scenario, direct cash

Pediatric brain MRI. Pt. 1. Basic techniques

International Nuclear Information System (INIS)

Ho, Mai-Lan; Campeau, Norbert G.; Welker, Kirk M.; Ngo, Thang D.; Udayasankar, Unni K.

2017-01-01

Pediatric neuroimaging is a complex and specialized field that uses magnetic resonance (MR) imaging as the workhorse for diagnosis. Standard MR techniques used in adult neuroimaging are suboptimal for imaging in pediatrics because there are significant differences in the child's developing brain. These differences include size, myelination and sulcation. MR protocols need to be tailored to the specific indication and reviewed by the supervising radiologist in real time, and the specialized needs of this population require careful consideration of issues such as scan timing, sequence order, sedation, anesthesia and gadolinium administration. In part 1 of this review, we focus on basic protocol development and anatomical characterization. We provide multiple imaging examples optimized for evaluation of supratentorial and infratentorial brain, midline structures, head and neck, and intracranial vasculature. (orig.)

Pediatric brain MRI. Pt. 1. Basic techniques

Energy Technology Data Exchange (ETDEWEB)

Ho, Mai-Lan; Campeau, Norbert G.; Welker, Kirk M. [Mayo Clinic, Department of Radiology, Rochester, MN (United States); Ngo, Thang D. [Nemours Children' s Hospital, Department of Radiology, Orlando, FL (United States); Udayasankar, Unni K. [University of Arizona, Department of Radiology, Tucson, AZ (United States)

2017-05-15

Pediatric neuroimaging is a complex and specialized field that uses magnetic resonance (MR) imaging as the workhorse for diagnosis. Standard MR techniques used in adult neuroimaging are suboptimal for imaging in pediatrics because there are significant differences in the child's developing brain. These differences include size, myelination and sulcation. MR protocols need to be tailored to the specific indication and reviewed by the supervising radiologist in real time, and the specialized needs of this population require careful consideration of issues such as scan timing, sequence order, sedation, anesthesia and gadolinium administration. In part 1 of this review, we focus on basic protocol development and anatomical characterization. We provide multiple imaging examples optimized for evaluation of supratentorial and infratentorial brain, midline structures, head and neck, and intracranial vasculature. (orig.)

Basic Information about Your Drinking Water

Science.gov (United States)

... Offices Regional Offices Labs and Research Centers Ground Water and Drinking Water Contact Us Share Basic Information about Your Drinking Water Infographic: How does your water system work? The ...

Flavanol-rich cocoa consumption enhances exercise-induced executive function improvements in humans.

Science.gov (United States)

Tsukamoto, Hayato; Suga, Tadashi; Ishibashi, Aya; Takenaka, Saki; Tanaka, Daichi; Hirano, Yoshitaka; Hamaoka, Takafumi; Goto, Kazushige; Ebi, Kumiko; Isaka, Tadao; Hashimoto, Takeshi

2018-02-01

Aerobic exercise is known to acutely improve cognitive functions, such as executive function (EF) and memory function (MF). Additionally, consumption of flavanol-rich cocoa has been reported to acutely improve cognitive function. The aim of this study was to determine whether high cocoa flavanol (CF; HCF) consumption would enhance exercise-induced improvement in cognitive function. To test this hypothesis, we examined the combined effects of HCF consumption and moderate-intensity exercise on EF and MF during postexercise recovery. Ten healthy young men received either an HCF (563 mg of CF) or energy-matched low CF (LCF; 38 mg of CF) beverage 70 min before exercise in a single-blind counterbalanced manner. The men then performed moderate-intensity cycling exercise at 60% of peak oxygen uptake for 30 min. The participants performed a color-word Stroop task and face-name matching task to evaluate EF and MF, respectively, during six time periods throughout the experimental session. EF significantly improved immediately after exercise compared with before exercise in both conditions. However, EF was higher after HCF consumption than after LCF consumption during all time periods because HCF consumption improved EF before exercise. In contrast, HCF consumption and moderate-intensity exercise did not improve MF throughout the experiment. The present findings demonstrated that HCF consumption before moderate-intensity exercise could enhance exercise-induced improvement in EF, but not in MF. Therefore, we suggest that the combination of HCF consumption and aerobic exercise may be beneficial for improving EF. Copyright © 2017 Elsevier Inc. All rights reserved.

The T-cell receptor beta chain CDR3 region of BV8S1/BJ1S5 transcripts in type 1 diabetes.

Science.gov (United States)

Naserke, H E; Durinovic-Bellò, I; Seidel, D; Ziegler, A G

1996-01-01

We recently described the T-cell receptor (TCR) beta chain CDR3 motif S-SDRLG-NQPQH (BV8S1-BJ1S5) in an islet-specific T-cell clone (K2.12) from a type 1 diabetic patient (AS). A similar motif (RLGNQ) was also reported in a T-cell clone of non-obese diabetic (NOD) mice by others. In order to determine the frequency of our motif in selected and unselected T-cell populations, we cloned and sequenced the CDR3 region of BV8S1-BJ1S5 transcripts. These transcripts were derived from unstimulated peripheral blood T lymphocytes from two type 1 diabetic patients (AS and FS) and their non-diabetic sibling (WS), as well as from an islet-specific T-cell line of one of the patients. In addition, we compared the structure and composition of the CDR3 region in BV8S1-BJ1S5 transcripts from peripheral blood T cells between the patients and their non-diabetic sibling (>50 sequences each). We found that 30% of the islet-specific T-cell line cDNA clones expressed the entire sequence-motif, whereas it was absent in the clones of unstimulated peripheral blood T cells from both patients and their non-diabetic sibling. The average length of the CDR3 region was shorter in the patients (mean AS 9.9, FS 9.9, versus WS 10.7, p = 0.0037) and the number of inserted nucleotides in N nucleotide addition at the DJ-junction lower (mean AS 3.5, FS 3. 2, versus WS 5.2, P = diabetic sibling. Moreover, the pattern of amino acid usage in the CDR3 region was dissimilar at positions 5 and 6, where polar amino acids predominated in both diabetic siblings. In contrast, basic amino acids are preferentially used at position 5 in the clones of the non-diabetic sibling. These data provide information on the general structure of the TCR(BV8S1-BJ1S5) CDR3 region in type 1 diabetes and may indicate differences in the amino and nucleic acid composition of the TCR beta chain CDR3 region between two type 1 diabetic patients and their non-diabetic sibling.

Insertion and crossing region design

International Nuclear Information System (INIS)

Wienands, U.; Beloshitsky, P.

2001-01-01

This article is the summary of the 5-afternoon tutorial on insertions for circular machines. Roughly half the course (Part 1) was spent discussing interaction regions, We start by recapitulating basic beam optics including building blocks. This provides the tools to analyze the basic structure of interaction regions and explore the parameter space. This simple example is then successively refined and made more realistic. Examples of realized interaction regions for both hadron and electron machines are shown and their salient features and differences explained. A brief discussion of solenoid-decoupling brings Part 1 to a close. In Part 2 we discussed various utility sections. Dispersion suppressors are presented in detail discussing the principles as well as the practical implementation of flexible suppressors using LEP as an example. Injection schemes, both single-turn and multi-turn stacking, are presented in depth. The matching of wiggler and undulator insertions and a discussion of the impact of these devices on beam parameters closes out Part 2

Aegle marmelos Mediated Green Synthesis of Different Nanostructured Metal Hexacyanoferrates: Activity against Photodegradation of Harmful Organic Dyes

Directory of Open Access Journals (Sweden)

Vidhisha Jassal

2016-01-01

Full Text Available Prussian blue analogue potassium metal hexacyanoferrate (KMHCF nanoparticles Fe4[Fe(CN6]3 (FeHCF, K2Cu3[Fe(CN6]2 (KCuHCF, K2Ni[Fe(CN6]·3H2O (KNiHCF, and K2Co[Fe(CN6] (KCoHCF have been synthesized using plant based biosurfactant Aegle marmelos (Bael and water as a green solvent. It must be emphasized here that no harmful reagent or solvent was used throughout the study. Plant extracts are easily biodegradable and therefore do not cause any harm to the environment. Hence, the proposed method of synthesis of various KMHCF nanoparticles followed a green path. The synthesized nanoparticles were characterized by powder X-ray diffraction (PXRD, Field-Emission Scanning Electron Microscopy (FE-SEM, Transmission Electron Microscopy (TEM, and Fourier Transform Infrared Spectroscopy (FT-IR. MHCF nanoparticles were used for the photocatalytic degradation of toxic dyes like Malachite Green (MG, Eriochrome Black T (EBT, Methyl Orange (MO, and Methylene Blue (MB. Under optimized reaction conditions, maximum photocatalytic degradation was achieved in case of KCuHCF nanoparticles mediated degradation process (MG: 96.06%, EBT: 83.03%, MB: 94.72%, and MO: 63.71% followed by KNiHCF (MG: 95%, EBT: 80.32%, MB: 91.35%, and MO: 59.42%, KCoHCF (MG: 91.45%, EBT: 78.84%, MB: 89.28%, and MO: 58.20%.

The form and context of federalism: meanings for health care financing.

Science.gov (United States)

France, George

2008-08-01

This article examines the meaning of federalism for health care financing (HCF) and is based on two considerations. First, federal institutions are embedded in their national context and interact with them. The design and performance of HCF policy will be influenced by contexts, the workings of the federal institutions, and the interactions of these institutions with different elements of the context. This article unravels these influences. Second, there is no unique model of federalism, and so we have to specify the particular form to which we refer. The examination of the influence of federalism and its context on HCF policy is facilitated by using a transnational comparative approach, and this article examines four mature federations: the United States, Australia, Canada, and Germany. The relatively poor performance of the U.S. HCF system seems associated with the fact that it operates in a context markedly less benign than those of the other national HCF systems. Heterogeneity of context appears also to have contributed to important differences between the United States and the other countries in the design of HCF policies. An analysis of how federalism works in practice suggests that, while U.S. federalism may be overall less favorable to the development of well-functioning HCF policies, the inferior performance of these policies is to be principally attributed to context.

Inequality in Housing and Basic Amenities in India

OpenAIRE

Pal, Rama; Aneja, Neil; Nagpal, Dhruv

2015-01-01

The paper analyses inequality in housing conditions for India for two time period 2008-09 and 2012. Housing conditions are important determinants of health status. Access to descent housing and basic amenities is essential to improve health status of people. Given this backdrop, we examine the distribution of housing and basic amenities, namely, drinking water, toilets and electricity, across regions and over time. We also study the determinants of access to these basic amenities. The re...

Functional analysis of the C-terminal region of human adenovirus E1A reveals a misidentified nuclear localization signal

Energy Technology Data Exchange (ETDEWEB)

Cohen, Michael J.; King, Cason R.; Dikeakos, Jimmy D. [Department of Microbiology and Immunology, The University of Western Ontario, A4-833 London Regional Cancer Centre, 800 Commissioners Road E., London, Ontario, N6A 4L6 Canada (Canada); Mymryk, Joe S., E-mail: jmymryk@uwo.ca [Department of Microbiology and Immunology, The University of Western Ontario, A4-833 London Regional Cancer Centre, 800 Commissioners Road E., London, Ontario, N6A 4L6 Canada (Canada); Department of Oncology, The University of Western Ontario, London Regional Cancer Centre, Ontario (Canada)

2014-11-15

The immortalizing function of the human adenovirus 5 E1A oncoprotein requires efficient localization to the nucleus. In 1987, a consensus monopartite nuclear localization sequence (NLS) was identified at the C-terminus of E1A. Since that time, various experiments have suggested that other regions of E1A influence nuclear import. In addition, a novel bipartite NLS was recently predicted at the C-terminal region of E1A in silico. In this study, we used immunofluorescence microscopy and co-immunoprecipitation analysis with importin-α to verify that full nuclear localization of E1A requires the well characterized NLS spanning residues 285–289, as well as a second basic patch situated between residues 258 and 263 ({sup 258}RVGGRRQAVECIEDLLNEPGQPLDLSCKRPRP{sup 289}). Thus, the originally described NLS located at the C-terminus of E1A is actually a bipartite signal, which had been misidentified in the existing literature as a monopartite signal, altering our understanding of one of the oldest documented NLSs. - Highlights: • Human adenovirus E1A is localized to the nucleus. • The C-terminus of E1A contains a bipartite nuclear localization signal (NLS). • This signal was previously misidentified to be a monopartite NLS. • Key basic amino acid residues within this sequence are highly conserved.

12 CFR 900.1 - Basic terms relating to the Finance Board, the Bank System and related entities.

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Basic terms relating to the Finance Board, the... GENERAL DEFINITIONS GENERAL DEFINITIONS APPLYING TO ALL FINANCE BOARD REGULATIONS § 900.1 Basic terms... following basic terms relating to the Finance Board, the Bank System and related entities have the meanings...

Basic life support: evaluation of learning using simulation and immediate feedback devices1.

Science.gov (United States)

Tobase, Lucia; Peres, Heloisa Helena Ciqueto; Tomazini, Edenir Aparecida Sartorelli; Teodoro, Simone Valentim; Ramos, Meire Bruna; Polastri, Thatiane Facholi

2017-10-30

to evaluate students' learning in an online course on basic life support with immediate feedback devices, during a simulation of care during cardiorespiratory arrest. a quasi-experimental study, using a before-and-after design. An online course on basic life support was developed and administered to participants, as an educational intervention. Theoretical learning was evaluated by means of a pre- and post-test and, to verify the practice, simulation with immediate feedback devices was used. there were 62 participants, 87% female, 90% in the first and second year of college, with a mean age of 21.47 (standard deviation 2.39). With a 95% confidence level, the mean scores in the pre-test were 6.4 (standard deviation 1.61), and 9.3 in the post-test (standard deviation 0.82, p basic cardiopulmonary resuscitation, according to the feedback device; 43.7 (standard deviation 26.86) mean duration of the compression cycle by second of 20.5 (standard deviation 9.47); number of compressions 167.2 (standard deviation 57.06); depth of compressions of 48.1 millimeter (standard deviation 10.49); volume of ventilation 742.7 (standard deviation 301.12); flow fraction percentage of 40.3 (standard deviation 10.03). the online course contributed to learning of basic life support. In view of the need for technological innovations in teaching and systematization of cardiopulmonary resuscitation, simulation and feedback devices are resources that favor learning and performance awareness in performing the maneuvers.

Interference Cancellation for Hollow-Core Fiber Reference Cells

DEFF Research Database (Denmark)

Seppä, Jeremias; Merimaa, Mikko; Merimaa, Mikko

2015-01-01

Doppler-free saturated absorption spectroscopy of gases in hollow-core fiber (HCF)-based cells can be used for realizing new compact, robust, and portable frequency standards. In this paper, methods for cancelling interferences resulting from the optical connections between standard fiber and HCF...... and other factors such as varying coupling to HCF modes are investigated. Laser power modulation with simultaneous detection of ac and dc signal is used to separate saturated absorption from interferences. In addition, a technique of two piezoelectric stack actuators stretching the fiber at different...... locations is described. The presented experimental results demonstrate that 99% interference attenuation is readily attainable with the techniques. Frequency comb-referenced measurement of saturated acetylene absorption features near 1.54 μm, with fiber length and power modulation, is presented...

Proteolytic processing of connective tissue growth factor in normal ocular tissues and during corneal wound healing.

Science.gov (United States)

Robinson, Paulette M; Smith, Tyler S; Patel, Dilan; Dave, Meera; Lewin, Alfred S; Pi, Liya; Scott, Edward W; Tuli, Sonal S; Schultz, Gregory S

2012-12-13

Connective tissue growth factor (CTGF) is a fibrogenic cytokine that is up-regulated by TGF-β and mediates most key fibrotic actions of TGF-β, including stimulation of synthesis of extracellular matrix and differentiation of fibroblasts into myofibroblasts. This study addresses the role of proteolytic processing of CTGF in human corneal fibroblasts (HCF) stimulated with TGF-β, normal ocular tissues and wounded corneas. Proteolytic processing of CTGF in HCF cultures, normal animal eyes, and excimer laser wounded rat corneas were examined by Western blot. The identity of a 21-kDa band was determined by tandem mass spectrometry, and possible alternative splice variants of CTGF were assessed by 5' Rapid Amplification of cDNA Ends (RACE). HCF stimulated by TGF-β contained full length 38-kDa CTGF and fragments of 25, 21, 18, and 13 kDa, while conditioned medium contained full length 38- and a 21-kDa fragment of CTGF that contained the middle "hinge" region of CTGF. Fragmentation of recombinant CTGF incubated in HCF extracts was blocked by the aspartate protease inhibitor, pepstatin. Normal mouse, rat, and rabbit whole eyes and rabbit ocular tissues contained abundant amounts of C-terminal 25- and 21-kDa fragments and trace amounts of 38-kDa CTGF, although no alternative transcripts were detected. All forms of CTGF (38, 25, and 21 kDa) were detected during healing of excimer ablated rat corneas, peaking on day 11. Proteolytic processing of 38-kDa CTGF occurs during corneal wound healing, which may have important implications in regulation of corneal scar formation.

Discrete Neural Signatures of Basic Emotions.

Science.gov (United States)

Saarimäki, Heini; Gotsopoulos, Athanasios; Jääskeläinen, Iiro P; Lampinen, Jouko; Vuilleumier, Patrik; Hari, Riitta; Sams, Mikko; Nummenmaa, Lauri

2016-06-01

Categorical models of emotions posit neurally and physiologically distinct human basic emotions. We tested this assumption by using multivariate pattern analysis (MVPA) to classify brain activity patterns of 6 basic emotions (disgust, fear, happiness, sadness, anger, and surprise) in 3 experiments. Emotions were induced with short movies or mental imagery during functional magnetic resonance imaging. MVPA accurately classified emotions induced by both methods, and the classification generalized from one induction condition to another and across individuals. Brain regions contributing most to the classification accuracy included medial and inferior lateral prefrontal cortices, frontal pole, precentral and postcentral gyri, precuneus, and posterior cingulate cortex. Thus, specific neural signatures across these regions hold representations of different emotional states in multimodal fashion, independently of how the emotions are induced. Similarity of subjective experiences between emotions was associated with similarity of neural patterns for the same emotions, suggesting a direct link between activity in these brain regions and the subjective emotional experience. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Comparison of cardiovascular protective effects of tropical seaweeds, Kappaphycus alvarezii, Caulerpa lentillifera, and Sargassum polycystum, on high-cholesterol/high-fat diet in rats.

Science.gov (United States)

Matanjun, Patricia; Mohamed, Suhaila; Muhammad, Kharidah; Mustapha, Noordin Mohamed

2010-08-01

This study was designed to investigate the comparative in vivo cardiovascular protective effects of red, green, and brown tropical seaweeds, namely, Kappaphycus alvarezii (or Eucheuma cottonii), Caulerpa lentillifera, and Sargassum polycystum, in rats fed on high-cholesterol/high-fat (HCF) diets. Male Sprague-Dawley rats (weighing 260-300 g) on the HCF diet had significantly increased body weight, plasma total cholesterol (TC), plasma low-density lipoprotein cholesterol (LDL-C), plasma triglycerides (TG), lipid peroxidation, and erythrocyte glutathione peroxidase (GSH-Px) and superoxide dismutase levels after 16 weeks. Supplementing 5% seaweeds to HCF diet significantly reduced plasma TC (-11.4% to -18.5%), LDL-C (-22% to -49.3%), and TG (-33.7% to -36.1%) levels and significantly increased HDL-C levels (16.3-55%). Among the seaweeds, S. polycystum showed the best anti-obesity and blood GSH-Px properties, K. alvarezii showed the best antihyperlipemic and in vivo antioxidation effects, and C. lentillifera was most effective at reducing plasma TC. All seaweeds significantly reduced body weight gain, erythrocyte GSH-Px, and plasma lipid peroxidation of HCF diet rats towards the values of normal rats.

Selective removal of cesium from aqueous solutions with nickel (II) hexacyanoferrate (III) functionalized agricultural residue-walnut shell.

Science.gov (United States)

Ding, Dahu; Lei, Zhongfang; Yang, Yingnan; Feng, Chuanping; Zhang, Zhenya

2014-04-15

A novel nickel (II) hexacyanoferrate (III) functionalized agricultural residue-walnut shell (Ni(II)HCF(III)-WS) was developed to selectively remove cesium ion (Cs(+)) from aqueous solutions. This paper showed the first integral study on Cs(+) removal behavior and waste reduction analysis by using biomass adsorption material. The results indicated that the removal process was rapid and reached saturation within 2h. As a special characteristic of Ni(II)HCF(III)-WS, acidic condition was preferred for Cs(+) removal, which was useful for extending the application scope of the prepared biomass material in treating acidic radioactive liquid waste. The newly developed Ni(II)HCF(III)-WS could selectively remove Cs(+) though the coexisting ions (Na(+) and K(+) in this study) exhibited negative effects. In addition, approximately 99.8% (in volume) of the liquid waste was reduced by using Ni(II)HCF(III)-WS and furthermore 91.9% (in volume) of the spent biomass material (Cs-Ni(II)HCF(III)-WS) was reduced after incineration (at 500°C for 2h). Due to its relatively high distribution coefficient and significant volume reduction, Ni(II)HCF(III)-WS is expected to be a promising material for Cs(+) removal in practice. Copyright © 2014 Elsevier B.V. All rights reserved.

Basic Cake Decorating Workbook.

Science.gov (United States)

Bogdany, Mel

Included in this student workbook for basic cake decorating are the following: (1) Drawings of steps in a basic way to ice a layer cake, how to make a paper cone, various sizes of flower nails, various sizes and types of tin pastry tubes, and special rose tubes; (2) recipes for basic decorating icings (buttercream, rose paste, and royal icing);…

Basic concepts in oceanography

International Nuclear Information System (INIS)

Small, L.F.

1997-01-01

Basic concepts in oceanography include major wind patterns that drive ocean currents, and the effects that the earth's rotation, positions of land masses, and temperature and salinity have on oceanic circulation and hence global distribution of radioactivity. Special attention is given to coastal and near-coastal processes such as upwelling, tidal effects, and small-scale processes, as radionuclide distributions are currently most associated with coastal regions. (author)

Users guide to REGIONAL-1: a regional assessment model

International Nuclear Information System (INIS)

Davis, W.E.; Eadie, W.J.; Powell, D.C.

1979-09-01

A guide was prepared to allow a user to run the PNL long-range transport model, REGIONAL 1. REGIONAL 1 is a computer model set up to run atmospheric assessments on a regional basis. The model has the capability of being run in three modes for a single time period. The three modes are: (1) no deposition, (2) dry deposition, (3) wet and dry deposition. The guide provides the physical and mathematical basis used in the model for calculating transport, diffusion, and deposition for all three modes. Also the guide includes a program listing with an explanation of the listings and an example in the form of a short-term assessment for 48 hours. The purpose of the example is to allow a person who has past experience with programming and meteorology to operate the assessment model and compare his results with the guide results. This comparison will assure the user that the program is operating in a proper fashion

Spline approximation, Part 1: Basic methodology

Science.gov (United States)

Ezhov, Nikolaj; Neitzel, Frank; Petrovic, Svetozar

2018-04-01

In engineering geodesy point clouds derived from terrestrial laser scanning or from photogrammetric approaches are almost never used as final results. For further processing and analysis a curve or surface approximation with a continuous mathematical function is required. In this paper the approximation of 2D curves by means of splines is treated. Splines offer quite flexible and elegant solutions for interpolation or approximation of "irregularly" distributed data. Depending on the problem they can be expressed as a function or as a set of equations that depend on some parameter. Many different types of splines can be used for spline approximation and all of them have certain advantages and disadvantages depending on the approximation problem. In a series of three articles spline approximation is presented from a geodetic point of view. In this paper (Part 1) the basic methodology of spline approximation is demonstrated using splines constructed from ordinary polynomials and splines constructed from truncated polynomials. In the forthcoming Part 2 the notion of B-spline will be explained in a unique way, namely by using the concept of convex combinations. The numerical stability of all spline approximation approaches as well as the utilization of splines for deformation detection will be investigated on numerical examples in Part 3.

Dynamical evolution of star-forming regions - II. Basic kinematics

Science.gov (United States)

Parker, Richard J.; Wright, Nicholas J.

2016-04-01

We follow the dynamical evolution of young star-forming regions with a wide range of initial conditions and examine how the radial velocity dispersion, σ, evolves over time. We compare this velocity dispersion to the theoretically expected value for the velocity dispersion if a region were in virial equilibrium, σvir and thus assess the virial state (σ/σvir) of these systems. We find that in regions that are initially subvirial, or in global virial equilibrium but subvirial on local scales, the system relaxes to virial equilibrium within several million years, or roughly 25-50 crossing times, according to the measured virial ratio. However, the measured velocity dispersion, σ, appears to be a bad diagnostic of the current virial state of these systems as it suggests that they become supervirial when compared to the velocity dispersion estimated from the virial mass, σvir. We suggest that this discrepancy is caused by the fact that the regions are never fully relaxed, and that the early non-equilibrium evolution is imprinted in the one-dimensional velocity dispersion at these early epochs. If measured early enough (interquartile range (IQR) dispersion, with measures of spatial structure, places stronger constraints on the dynamical history of a region than using the velocity dispersion in isolation.

Electrocatalytic behaviour of hybrid cobalt–manganese hexacyanoferrate film on glassy carbon electrode

International Nuclear Information System (INIS)

Vinu Mohan, A.M.; Rambabu, Gutru; Aswini, K.K.; Biju, V.M.

2014-01-01

A thin film of hybrid cobalt–manganese hexacyanoferrate (CoMnHCF), a redox mediator was electrodeposited on a glassy carbon (GC) electrode and was employed as an amperometric sensor towards L-Tryptophan (L-Trp). The hybrid film was characterized by Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction technique (XRD), scanning electron microscope–energy dispersive X-ray spectroscopy (SEM–EDAX), and electrochemical techniques. The atomic absorption spectroscopic analysis provided the stoichiometry of the hybrid film to be K 1.74-y Co y Mn 0.78 [Fe(CN) 6 ], y ≤ 0.68. The electrochemical impedance study revealed the excellent charge transfer properties of GC/CoMnHCF electrode. The voltammetric investigations demonstrated exceptional electrocatalytic properties of the hybrid film modified electrode when compared to that of bare GC, GC/CoHCF and GC/MnHCF electrodes, towards the L-Trp oxidation. The kinetic parameters such as electron transfer coefficient, the electron transfer rate constant, the diffusion coefficient and the catalytic rate constant for the electrooxidation process of L-Trp were investigated. The amperometric detection of L-Trp employing GC/CoMnHCF electrode possessed a good sensitivity of 10 × 10 −2 A M −1 cm −2 in a wide range of detection (2–200 μM) at a reduced overpotential of 680 mV. In addition, the proposed amperometric method was applied to the detection of L-Trp in commercial milk samples with reproducible results. - Highlights: • A hybrid cobalt–manganese hexacyanoferrate film was prepared. • The hybrid film possesses excellent charge transfer properties. • The hybrid film exhibits excellent electrocatalytic properties towards Tryptophan. • Tryptophan detection is possible from commercial milk samples

Preparation of 18F-FDG by basic hydrolysis on '1-pot' FDG synthesis module

International Nuclear Information System (INIS)

Li Qiming; Jin Rongbing; Fan Xijiang

2007-01-01

'1-pot' equipment is an automatic synthesis module of producing 18 F-FDG by acid hydrolysis process. Simple changes in the chemistry, plumbing, and programming of CPCU enable two back-to-back '1-pot' systems in a unit. The preparation of precursor of 18 F-FDG is the same with origin. The results of experiments showed that by basic hydrolysis procedure, the synthesis time is shorten from 45-50 min to 30-35 min, uncorrected synthesis yield can be increased from 45%-50% to 60%-65%, and the preparing procedure is stable. The quality of 18 F-FDG meets the requirements under USP fludeoxyglucose 18 F injection, radiochemical purity is more than 99% especially by HPLC. With '1-pot' FDG synthesis module Chemical Processing Control Unit (CPCU), 18 F-FDG can be prepared by basic hydrolysis process. (authors)

Oncology. Pt. 1. General part, epidemiology - pathogenesis - basic principles of therapy. 2. upd. ed.

International Nuclear Information System (INIS)

Hiddemann, Wolfgang; Bartram Claus R.

2010-01-01

The book Oncology is aimed to communicate the compiled knowledge on tumor development and cancer: fundamental knowledge base, practice related know-how for diagnostics and therapy. Part 1 includes the following chapters: epidemiology and pathogenesis, basic principles of diagnostics, basic principles of therapy, complication of malign growth, tumors in the gastrointestinal tract, female genital carcinomas, kidney and urinary tract carcinomas, respiratory tract and lung carcinomas, carcinomas in the head - neck area, bone and soft tissue carcinomas, pediatric tumors, hematological neoplasm, other carcinomas. The book can be used as reference for clinical work. [de

Gender Inequality in Basic Education in the Northern Region of Ghana

African Journals Online (AJOL)

with girls' education, availability of household resources, poverty and high ... boys than girls complete schooling, especially at the basic school (Kane, 2004). ... the time of the 2010 population census in Ghana, 36 percent of all males aged .... educated than the female children because of the fact that women marry out of the.

Basic considerations for the safety analysis report of the Greek Research Reactor-1 (GRR-1)

International Nuclear Information System (INIS)

Anoussis, J.N.; Chrysochoides, N.G.; Papastergiou, C.N.

1980-09-01

The basic considerations upon which the new revised Safety Analysis Report (SAR) for the GRR-1 will be based are presented. The format and the content the SAR will follow are given. A number of credible and less credible accidents is briefly analysed on the basis of present knowledge and experience for similar reactors, as well as the experience gained in the last 10 years of the GRR-1 operation at 5 MW. The accident caused by partial blockage of the cooling flow is considered to be the Maximum Credible Accident (MCA) for the GRR-1. The MCA is analysed and its radiological impact to the environment is estimated using conservative assumptions. (T.A.)

catalyzed oxidation of formamidine derivative by hexacyanoferrate(III

Indian Academy of Sciences (India)

triazol-3-yl) formamidine (ATF) by hexacyanoferrate(III) (HCF) was studied spectrophotometrically in aqueous alkalinemedium. Both uncatalyzed and catalyzed reactions showed first order kinetics with respect to [HCF],whereas the reaction ...

Version 1.1 of the international spinal cord injury skin and thermoregulation function basic data set.

Science.gov (United States)

Biering-Sørensen, F; Alexander, M S; van Asbeck, F W A; Donovan, W; Krassioukov, A; Post, M W M

2017-06-01

To describe the changes made to the international spinal cord injury (SCI) skin and thermoregulation function basic data set in version 1.1. International. An international working group reviewed suggested changes to the international SCI skin and thermoregulation function basic data set version 1.0. These changes were discussed and the agreed changes were made. Subsequently, the recommended adjustments were circulated for review to the International Spinal Cord Society (ISCoS) Executive and Scientific Committees, the American Spinal Injury Association (ASIA) Board, around 40 national and international societies, and to interested individuals who had signed up wishing to have the opportunity to review. In addition, the suggested changes were displayed at the ISCoS and ASIA websites for at least a month for possible comments. The recommendation 'largest diameter, including undermining' is changed to: 'Largest undermining', and a description of how to measure this is inserted. The 'smallest opening diameter' is changed to: 'Width' as the maximum dimension perpendicular to the length axis. In the literature, there is a tendency to replace 'grades' or 'stages' with 'categories'; therefore, the word 'category' is used instead of 'grade' or 'stage'. Impracticable measurements have been adjusted and new terminology adopted. All are to be found on ISCoS website: http://www.iscos.org.uk/international-sci-skin-and-thermoregulation-function-data-sets.

Field-aligned current signatures in the near-tail region. 2. Coupling between the region 1 and region 2 systems

International Nuclear Information System (INIS)

Ohtani, S.; Kokubun, S.; Nakamura, R.; Elphic, R.C.; Russell, C.T.; Baker, D.N.

1990-01-01

The development of the substorm-associated current system in the near-tail region is examined in the light of both experiment and theory. First, the March 28, 1979, event is examined intensively by using ground magnetometer data and satellite magnetic field and energetic particle data. The comparison of field-aligned current signatures at geosynchronous altitude and in the near-tail region indicates that the development of the region 1 system is not merely the enhancement in current intensity of the pre-existing system. This finding is consistent with the so-called current wedge model, in which the tail current is converted into a pair of field-aligned currents with the region 1 polarity at substorm onsets. Detailed inspection, however, suggests that the region 2 system is as important as the region 1 system. Statistical properties of the azimuthal magnetic component at synchronous orbit indicate that the deviation during disturbed periods is larger than expected from the enhancement of the region 1 current. These individual and statistical studies suggest that the region 2 system tends to develop in the synchronous region and that the coupling between the region 1 and the region 2 systems is important. The current closure in the magnetosphere is discussed from a viewpoint of the macroscopic behavior of plasma. It is suggested that the dawnside and the duskside region 2 currents are closed in the magnetosphere by the curvature current during the growth phase and by the magnetic gradient current during the expansion phase. The field-aligned currents of the region 1 and the region 2 systems are closed in the ionosphere by the Pedersen current. Consequently, the energy is dissipated as the Joule heating and this energy must be supplied from the magnetosphere. Therefore, the counter part of the Pedersen current, which closes the region 1 and the region 2 currents in magnetosphere, must be the dynamo current

Basic amino acid residues located in the N-terminal region of BEND3 are essential for its nuclear localization

Energy Technology Data Exchange (ETDEWEB)

Shiheido, Hirokazu, E-mail: shiheido@ak.med.kyoto-u.ac.jp; Shimizu, Jun

2015-02-20

BEN domain-containing protein 3 (BEND3) has recently been reported to function as a heterochromatin-associated protein in transcriptional repression in the nucleus. BEND3 should have nuclear localization signals (NLSs) to localize to the nucleus in light of its molecular weight, which is higher than that allowed to pass through nuclear pore complexes. We here analyzed the subcellular localization of deletion/site-directed mutants of human BEND3 by an immunofluorescence assay in an attempt to identify the amino acids essential for its nuclear localization. We found that three basic amino acid residues located in the N-terminal region of BEND3 (BEND3{sub 56–58}, KRK) are essential, suggesting that these residues play a role as a functional NLS. These results provide valuable information for progressing research on BEND3. - Highlights: • BEND3 localizes to the nucleus. • The N-terminal 60 amino acids region of BEND3 contains NLS. • Amino acids located between 56 and 58 of BEND3 (KRK) are part of NLS. • KRK motif is highly conserved among BEND3 homologs.

Quantum electronics basic theory

CERN Document Server

Fain, V M; Sanders, J H

1969-01-01

Quantum Electronics, Volume 1: Basic Theory is a condensed and generalized description of the many research and rapid progress done on the subject. It is translated from the Russian language. The volume describes the basic theory of quantum electronics, and shows how the concepts and equations followed in quantum electronics arise from the basic principles of theoretical physics. The book then briefly discusses the interaction of an electromagnetic field with matter. The text also covers the quantum theory of relaxation process when a quantum system approaches an equilibrium state, and explai

Basic Automotive Mechanics. Florida Vocational Program Guide.

Science.gov (United States)

University of South Florida, Tampa. Dept. of Adult and Vocational Education.

This program guide identifies primary concerns in the organization, operation, and evaluation of a basic automotive mechanics program. It is designed for local school district and community college administrators, instructors, program advisory committees, and regional coordinating councils. The guide begins with the Dictionary of Occupational…

Label Review Training: Module 1: Label Basics, Page 21

Science.gov (United States)

This module of the pesticide label review training provides basic information about pesticides, their labeling and regulation, and the core principles of pesticide label review. Learn about types of labels.

Notch size effects on high cycle fatigue limit stress of Udimet 720

International Nuclear Information System (INIS)

Ren Weiju; Nicholas, Theodore

2003-01-01

Notch size effects on the high cycle fatigue (HCF) limit stress of Ni-base superalloy Udimet 720 were investigated on cylindrical specimens with three notch sizes of the same stress concentration factor K t =2.74. The HCF limit stress corresponding to a life of 10 6 cycles was experimentally determined at a stress ratio of 0.1 and a frequency of 25 Hz at room temperature. The stresses were calculated using finite element analysis (FEA) and the specimens analyzed using scanning electron microscopy (SEM). Test results show that at the same K t value, notch size can slightly affect the HCF limit stress of U720 when notch root plasticity occurs. FEA and SEM results reveal that the notch size effects are influenced by a complicated combination of the stress and plastic strain fields at the notch tip, the nominal stress, and the effects of prior plastic deformation on fatigue crack initiation

Label Review Training: Module 1: Label Basics, Page 22

Science.gov (United States)

This module of the pesticide label review training provides basic information about pesticides, their labeling and regulation, and the core principles of pesticide label review. Learn about what labels require review.

Label Review Training: Module 1: Label Basics, Page 19

Science.gov (United States)

This module of the pesticide label review training provides basic information about pesticides, their labeling and regulation, and the core principles of pesticide label review. This section covers supplemental distributor labeling.

Prediction of the saturated hydraulic conductivity from Brooks and Corey’s water retention parameters

NARCIS (Netherlands)

Nasta, P.; Vrugt, J.A.; Romano, N.

2013-01-01

Prediction of flow through variably saturated porous media requires accurate knowledge of the soil hydraulic properties, namely the water retention function (WRF) and the hydraulic conductivity function (HCF). Unfortunately, direct measurement of the HCF is time consuming and expensive. In this

Label Review Training: Module 1: Label Basics, Page 15

Science.gov (United States)

This module of the pesticide label review training provides basic information about pesticides, their labeling and regulation, and the core principles of pesticide label review. Learn about the consequences of improper labeling.

Label Review Training: Module 1: Label Basics, Page 14

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This module of the pesticide label review training provides basic information about pesticides, their labeling and regulation, and the core principles of pesticide label review. Learn about positive effects from proper labeling.

Label Review Training: Module 1: Label Basics, Page 18

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This module of the pesticide label review training provides basic information about pesticides, their labeling and regulation, and the core principles of pesticide label review. This section discusses the types of labels.

Label Review Training: Module 1: Label Basics, Page 26

Science.gov (United States)

This module of the pesticide label review training provides basic information about pesticides, their labeling and regulation, and the core principles of pesticide label review. Learn about mandatory and advisory label statements.

Impact of advanced and basic carbohydrate counting methods on metabolic control in patients with type 1 diabetes.

Science.gov (United States)

Souto, Débora Lopes; Zajdenverg, Lenita; Rodacki, Melanie; Rosado, Eliane Lopes

2014-03-01

Diets based on carbohydrate counting remain a key strategy for improving glycemic control in patients with type 1 diabetes. However, these diets may promote weight gain because of the flexibility in food choices. The aim of this study was to compare carbohydrate counting methods regarding anthropometric, biochemical, and dietary variables in individuals with type 1 diabetes, as well as to evaluate their knowledge about nutrition. Participants were allocated in basic or advanced groups. After 3 mo of the nutritional counseling, dietary intake, anthropometric variables, lipemia, and glycemic control were compared between groups. A questionnaire regarding carbohydrate counting, sucrose intake, nutritional knowledge, and diabetes and nutrition taboos also was administered. Ten (30%) participants had already used advanced carbohydrate counting before the nutritional counseling and these individuals had a higher body mass index (BMI) (P 1) and waist circumference (WC) (P = 0.01) than others (n = 23; 69.7%). After 3 mo of follow-up, although participants in the advanced group (n = 17; 51.52%) presented higher BMI (P 1) and WC (P = 0.03), those in the basic group (n = 16; 48.48%) showed a higher fat intake (P 1). The majority of participants reported no difficulty in following carbohydrate counting (62.5% and 88% for basic and advanced groups, respectively) and a greater flexibility in terms of food choices (>90% with both methods). Advanced carbohydrate counting did not affect lipemic and glycemic control in individuals with type 1 diabetes, however, it may increase food intake, and consequently the BMI and WC, when compared to basic carbohydrate counting. Furthermore, carbohydrate counting promoted greater food flexibility. Copyright © 2014 Elsevier Inc. All rights reserved.

Label Review Training: Module 1: Label Basics, Page 25

Science.gov (United States)

This module of the pesticide label review training provides basic information about pesticides, their labeling and regulation, and the core principles of pesticide label review: clarity, accuracy, consistency with EPA policy, and enforceability.

Label Review Training: Module 1: Label Basics, Page 24

Science.gov (United States)

This module of the pesticide label review training provides basic information about pesticides, their labeling and regulation, and the core principles of pesticide label review. This page is about which labels require review.

Label Review Training: Module 1: Label Basics, Page 27

Science.gov (United States)

This module of the pesticide label review training provides basic information about pesticides, their labeling and regulation, and the core principles of pesticide label review. See examples of mandatory and advisory label statements.

Label Review Training: Module 1: Label Basics, Page 17

Science.gov (United States)

This module of the pesticide label review training provides basic information about pesticides, their labeling and regulation, and the core principles of pesticide label review. See an overview of the importance of labels.

Label Review Training: Module 1: Label Basics, Page 23

Science.gov (United States)

This module of the pesticide label review training provides basic information about pesticides, their labeling and regulation, and the core principles of pesticide label review. Lists types of labels that do not require review.

Development of Optimized Core Design and Analysis Methods for High Power Density BWRs

Science.gov (United States)

Shirvan, Koroush

temperature was kept the same for the BWR-HD and ABWR which resulted in 4 °K cooler core inlet temperature for the BWR-HD given that its feedwater makes up a larger fraction of total core flow. The stability analysis using the STAB and S3K codes showed satisfactory results for the hot channel, coupled regional out-of-phase and coupled core-wide in-phase modes. A RELAPS model of the ABWR system was constructed and applied to six transients for the BWR-HD and ABWR. The 6MCPRs during all the transients were found to be equal or less for the new design and the core remained covered for both. The lower void coefficient along with smaller core volume proved to be advantages for the simulated transients. Helical Cruciform Fuel (HCF) rods were proposed in prior MIT studies to enhance the fuel surface to volume ratio. In this work, higher fidelity models (e.g. CFD instead of subchannel methods for the hydraulic behaviour) are used to investigate the resolution needed for accurate assessment of the HCF design. For neutronics, conserving the fuel area of cylindrical rods results in a different reactivity level with a lower void coefficient for the HCF design. In single-phase flow, for which experimental results existed, the friction factor is found to be sensitive to HCF geometry and cannot be calculated using current empirical models. A new approach for analysis of flow crisis conditions for HCF rods in the context of Departure from Nucleate Boiling (DNB) and dryout using the two phase interface tracking method was proposed and initial results are presented. It is shown that the twist of the HCF rods promotes detachment of a vapour bubble along the elbows which indicates no possibility for an early DNB for the HCF rods and in fact a potential for a higher DNB heat flux. Under annular flow conditions, it was found that the twist suppressed the liquid film thickness on the HCF rods, at the locations of the highest heat flux, which increases the possibility of reaching early dryout. It

Label Review Training: Module 1: Label Basics, Page 16

Science.gov (United States)

This module of the pesticide label review training provides basic information about pesticides, their labeling and regulation, and the core principles of pesticide label review. Learn about the importance of labels and the role in enforcement.

Measuring regional authority

NARCIS (Netherlands)

Marks, G.W.; Hooghe, E.A.E.B.; Schakel, A.H.

2008-01-01

This article sets out a conceptual basis for measuring regional authority and engages basic measurement issues. Regional authority is disaggregated into two domains (self-rule and shared rule) and these are operationalised in eight dimensions. The article concludes by examining the robustness of

Selective removal of cesium from aqueous solutions with nickel (II) hexacyanoferrate (III) functionalized agricultural residue–walnut shell

International Nuclear Information System (INIS)

Ding, Dahu; Lei, Zhongfang; Yang, Yingnan; Feng, Chuanping; Zhang, Zhenya

2014-01-01

Highlights: • Novel biosorbent for cesium removal was derived from agricultural residue. • It could remove cesium effectively from aqueous solution. • Large size of granules makes it easy to be separated from solutions. • The volume of used biosorbent could be significantly reduced after incineration. • Incinerated biosorbent has a low volume and a low cost final disposal. - Abstract: A novel nickel (II) hexacyanoferrate (III) functionalized agricultural residue-walnut shell (Ni II HCF III -WS) was developed to selectively remove cesium ion (Cs + ) from aqueous solutions. This paper showed the first integral study on Cs + removal behavior and waste reduction analysis by using biomass adsorption material. The results indicated that the removal process was rapid and reached saturation within 2 h. As a special characteristic of Ni II HCF III -WS, acidic condition was preferred for Cs + removal, which was useful for extending the application scope of the prepared biomass material in treating acidic radioactive liquid waste. The newly developed Ni II HCF III -WS could selectively remove Cs + though the coexisting ions (Na + and K + in this study) exhibited negative effects. In addition, approximately 99.8% (in volume) of the liquid waste was reduced by using Ni II HCF III -WS and furthermore 91.9% (in volume) of the spent biomass material (Cs-Ni II HCF III -WS) was reduced after incineration (at 500 °C for 2 h). Due to its relatively high distribution coefficient and significant volume reduction, Ni II HCF III -WS is expected to be a promising material for Cs + removal in practice

Distinct pathways of neural coupling for different basic emotions.

Science.gov (United States)

Tettamanti, Marco; Rognoni, Elena; Cafiero, Riccardo; Costa, Tommaso; Galati, Dario; Perani, Daniela

2012-01-16

Emotions are complex events recruiting distributed cortical and subcortical cerebral structures, where the functional integration dynamics within the involved neural circuits in relation to the nature of the different emotions are still unknown. Using fMRI, we measured the neural responses elicited by films representing basic emotions (fear, disgust, sadness, happiness). The amygdala and the associative cortex were conjointly activated by all basic emotions. Furthermore, distinct arrays of cortical and subcortical brain regions were additionally activated by each emotion, with the exception of sadness. Such findings informed the definition of three effective connectivity models, testing for the functional integration of visual cortex and amygdala, as regions processing all emotions, with domain-specific regions, namely: i) for fear, the frontoparietal system involved in preparing adaptive motor responses; ii) for disgust, the somatosensory system, reflecting protective responses against contaminating stimuli; iii) for happiness: medial prefrontal and temporoparietal cortices involved in understanding joyful interactions. Consistently with these domain-specific models, the results of the effective connectivity analysis indicate that the amygdala is involved in distinct functional integration effects with cortical networks processing sensorimotor, somatosensory, or cognitive aspects of basic emotions. The resulting effective connectivity networks may serve to regulate motor and cognitive behavior based on the quality of the induced emotional experience. Copyright © 2011. Published by Elsevier Inc.

Mössbauer spectroscopic study of cobalt hexacyanoferrate nanoparticles: Effect of hydrogenation

Science.gov (United States)

Kumar, Asheesh; Kanagare, A. B.; Meena, Sher Singh; Banerjee, S.; Kumar, P.; Sudarsan, V.

2018-04-01

This paper reports Mössbauer study of cobalt hexacyanoferrate (CoHCF) before and after hydrogenation. The CoHCF was synthesised by chemical precipitation method. The sample was characterized by using various techniques (XRD, TG, EDX and FTIR). The CoHCF paricles show fcc structure. The hydrogen storage property was measured at different temperature. The COHCF shows maximum 0.93 wt% hydrogen storage capacity at 223K. 57Fe Mössbauer spectroscopic study shows the effect of hydrogenation on the electronic structure in terms of electronic charge distribution and volume expansion. Isomer shift and quadrupole splitting values were found to be increased after hydrogenation.

[Impact of a nutrition education intervention in teachers, preschool and basic school-age children in Valparaiso region in Chile].

Science.gov (United States)

Vio, Fernando; Salinas, Judith; Montenegro, Edith; González, Carmen Gloria; Lera, Lydia

2014-06-01

To assess the impact of a nutrition education program for teachers in the nutritional status, food knowledge and food consumption of their pre basic and basic students, and in the controls. A nutrition education intervention was conducted in pre basic and basic teachers in a school year, with a pre-post evaluation of their students, compared with a control group. Subjects were 817 students (389 men and 428 women) from pre kindergarten to the second grade. The 465 students of the intervened group were distributed in two schools (Liceo 1 = 283; Liceo 2 = 182) and 352 in the control school. The nutrition intervention consisted in 9 interactive workshops for teachers with the utilization of Information and Communication Technologies (ICT). The pre post evaluation consisted in a nutritional status assessment, and a food and nutrition survey with questions related with food knowledge and food consumption, at the beginning and at the end of the school year. There were no significant differences in nutritional status between the beginning and the end of the intervention. In one of the experimental schools (Liceo 2) there was a significant decrease in obesity, in women and in the age-group 7-9 years. In the experimental group there was a significant improvement in food knowledge and a decrease in non-healthy food consumption. In the control group, consumption of non-healthy food was stable, with a decrease in fruits and vegetables consumption. As it was demonstrated in similar studies, a short interactive nutrition education intervention with utilization of ICT in pre basic and basic teachers can produce positive changes in nutritional status of their students, improving food knowledge and healthy food consumption and decreasing non-healthy food consumption, compared with the control group. However, a strategy to incorporate parents in school nutrition education programs is still a pending issue. Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights

Evaluation of Membrane Ultrafiltration and Residual Chlorination as a Decentralized Water Treatment Strategy for Ten Rural Healthcare Facilities in Rwanda

Directory of Open Access Journals (Sweden)

Alexandra Huttinger

2015-10-01

Full Text Available There is a critical need for safe water in healthcare facilities (HCF in low-income countries. HCF rely on water supplies that may require additional on-site treatment, and need sustainable technologies that can deliver sufficient quantities of water. Water treatment systems (WTS that utilize ultrafiltration membranes for water treatment can be a useful technology in low-income countries, but studies have not systematically examined the feasibility of this technology in low-income settings. We monitored 22 months of operation of 10 WTS, including pre-filtration, membrane ultrafiltration, and chlorine residual disinfection that were donated to and operated by rural HCF in Rwanda. The systems were fully operational for 74% of the observation period. The most frequent reasons for interruption were water shortage (8% and failure of the chlorination mechanism (7%. When systems were operational, 98% of water samples collected from the HCF taps met World Health Organization (WHO guidelines for microbiological water quality. Water quality deteriorated during treatment interruptions and when water was stored in containers. Sustained performance of the systems depended primarily on organizational factors: the ability of the HCF technician to perform routine servicing and repairs, and environmental factors: water and power availability and procurement of materials, including chlorine and replacement parts in Rwanda.

Peer review, basic research, and engineering: Defining a role for QA professionals in basic research environments

Energy Technology Data Exchange (ETDEWEB)

Bodnarczuk, M.

1989-02-01

Within the context of doing basic research, this paper seeks to answer four major questions: (1) What is the authority structure of science. (2) What is peer review. (3) Where is the interface between basic physics research and standard engineering. and (4) Given the conclusions to the first three questions, what is the role of the QA professional in a basic research environment like Fermilab. 23 refs.

Supporting of some ferrocyanides on polyacrylonitrile (PAN) binding polymer and their application for cesium treatment

International Nuclear Information System (INIS)

Someda, H.H.; El Zahhar, A.A.; Shehata, M.K.; El-Naggar, H.A.

2001-01-01

Transition metal ferrocyanides were supported on polyacrylonitrile (PAN) as a binding polymer and were used for removal of radiocesium. The sorption capacity were determined for each sorbent and was found to be 1.22 and 0.65 meq/gm for KZnHCF-PAN and KCuHCF-PAN respectively. Different parameters affecting the sorption process were studied as chemical nature of the active solution, presence of competing ions and flow rate of feed solution. The regeneration of the used sorbent was studied using different solutions and also reusing the regenerated sorbent in other cycle up to four cycles (authors)

Structure-based design of ligands for protein basic domains: Application to the HIV-1 Tat protein

Science.gov (United States)

Filikov, Anton V.; James, Thomas L.

1998-05-01

A methodology has been developed for designing ligands to bind a flexible basic protein domain where the structure of the domain is essentially known. It is based on an empirical binding free energy function developed for highly charged complexes and on Monte Carlo simulations in internal coordinates with both the ligand and the receptor being flexible. HIV-1 encodes a transactivating regulatory protein called Tat. Binding of the basic domain of Tat to TAR RNA is required for efficient transcription of the viral genome. The structure of a biologically active peptide containing the Tat basic RNA-binding domain is available from NMR studies. The goal of the current project is to design a ligand which will bind to that basic domain and potentially inhibit the TAR-Tat interaction. The basic domain contains six arginine and two lysine residues. Our strategy was to design a ligand for arginine first and then a superligand for the basic domain by joining arginine ligands with a linker. Several possible arginine ligands were obtained by searching the Available Chemicals Directory with DOCK 3.5 software. Phytic acid, which can potentially bind multiple arginines, was chosen as a building block for the superligand. Calorimetric binding studies of several compounds to methylguanidine and Arg-/Lys-containing peptides were performed. The data were used to develop an empirical binding free energy function for prediction of affinity of the ligands for the Tat basic domain. Modeling of the conformations of the complexes with both the superligand and the basic domain being flexible has been carried out via Biased Probability Monte Carlo (BPMC) simulations in internal coordinates (ICM 2.6 suite of programs). The simulations used parameters to ensure correct folding, i.e., consistent with the experimental NMR structure of a 25-residue Tat peptide, from a random starting conformation. Superligands for the basic domain were designed by joining together two molecules of phytic acid with

Copper hexacyanoferrate functionalized single-walled carbon nano-tubes for selective cesium extraction

International Nuclear Information System (INIS)

Draouil, H.; Alvarez, L.; Bantignies, J.L.; Causse, J.; Cambedouzou, J.; Flaud, V.; Zaibi, M.A.; Oueslati, M.

2017-01-01

Single-walled carbon nano-tubes (SWCNTs) are functionalized with copper hexacyanoferrate (CuHCF) nanoparticles to prepare solid substrates for sorption of cesium ions (Cs + ) from liquid outflows. The high mechanical resistance and large electrical conductivity of SWCNTs are associated with the ability of CuHCF nanoparticles to selectively complex Cs + ions in order to achieve membrane-like buckypapers presenting high loading capacity of cesium. The materials are thoroughly characterized using electron microscopy, Raman scattering, X-ray photoelectron spectroscopy and thermogravimetric analyses. Cs sorption isotherms are plotted after having measured the Cs + concentration by liquid phase ionic chromatography in the solution before and after exposure to the materials. It is found that the total sorption capacity of the material reaches 230 mg.g -1 , and that about one third of the sorbed Cs (80 mg.g -1 ) is selectively complexed in the CuHCF nanoparticles grafted on SWCNTs. The quantification of Cs + ions on different sorption sites is made for the first time, and the high sorption rates open interesting outlooks in the integration of such materials in devices for the controlled sorption and desorption of these ions. (authors)

Constructing Regional advantage

DEFF Research Database (Denmark)

Asheim, Bjørn T.; Boschma, Ron; Cooke, Phil

2011-01-01

This paper presents a regional innovation policy model based on the idea of constructing regional advantage. This policy model brings together concepts like related variety, knowledge bases and policy platforms. Related variety attaches importance to knowledge spillovers across complementary...... economic development within and between regions in action lines appropriate to incorporate the basic principles behind related variety and differentiated knowledge bases....

Children and Their Basic Needs.

Science.gov (United States)

Prince, Debra Lindsey; Howard, Esther M.

2002-01-01

Describes obstacles presented by poverty in the fulfillment of the basic needs of children. Individually addresses Maslow's five basic needs with regard to children reared in poverty: (1) physiological needs; (2) safety needs; (3) belonging and love needs; (4) self-esteem needs; and (5) self-actualization needs. (Author/SD)

A Contribution to Nyquist-Rate ADC Modeling - Detailed Algorithm Description

Directory of Open Access Journals (Sweden)

J. Zidek

2012-04-01

Full Text Available In this article, the innovative ADC modeling algorithm is described. It is well suitable for nyquist-rate ADC error back annotation. This algorithm is the next step of building a support tool for IC design engineers. The inspiration for us was the work [2]. Here, the ADC behavior is divided into HCF (High Code Frequency and LCF (Low Code Frequency separated independent parts. This paper is based on the same concept but the model coefficients are estimated in a different way only from INL data. The HCF order recognition part was newly added as well. Thanks to that the HCF coefficients number is lower in comparison with the original Grimaldi’s work (especially for converters with low ratio between HCF and “random” part of INL. Modeling results are demonstrated on a real data set measured by ASICentrum on chargeredistribution type SAR ADC chip. Results are showed not only by coefficient values but also by the Model Coverage metrics. Model limitations are also discussed.

Basic Tilted Helix Bundle – A new protein fold in human FKBP25/FKBP3 and HectD1

International Nuclear Information System (INIS)

Helander, Sara; Montecchio, Meri; Lemak, Alexander; Farès, Christophe; Almlöf, Jonas; Li, Yanjun; Yee, Adelinda; Arrowsmith, Cheryl H.; Dhe-Paganon, Sirano; Sunnerhagen, Maria

2014-01-01

Highlights: • We describe the structure of a novel fold in FKBP25 and HectD. • The new fold is named the Basic Tilted Helix Bundle (BTHB) domain. • A conserved basic surface patch is presented, suggesting a functional role. - Abstract: In this paper, we describe the structure of a N-terminal domain motif in nuclear-localized FKBP25 1–73 , a member of the FKBP family, together with the structure of a sequence-related subdomain of the E3 ubiquitin ligase HectD1 that we show belongs to the same fold. This motif adopts a compact 5-helix bundle which we name the Basic Tilted Helix Bundle (BTHB) domain. A positively charged surface patch, structurally centered around the tilted helix H4, is present in both FKBP25 and HectD1 and is conserved in both proteins, suggesting a conserved functional role. We provide detailed comparative analysis of the structures of the two proteins and their sequence similarities, and analysis of the interaction of the proposed FKBP25 binding protein YY1. We suggest that the basic motif in BTHB is involved in the observed DNA binding of FKBP25, and that the function of this domain can be affected by regulatory YY1 binding and/or interactions with adjacent domains

Basic Tilted Helix Bundle – A new protein fold in human FKBP25/FKBP3 and HectD1

Energy Technology Data Exchange (ETDEWEB)

Helander, Sara; Montecchio, Meri [Department of Physics, Chemistry and Biology, Division of Chemistry, Linköping University, SE-58183 Linköping (Sweden); Lemak, Alexander [Princess Margaret Cancer Centre and Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 1L7 (Canada); Northeast Structural Genomics Consortium, Toronto, Ontario (Canada); Farès, Christophe [Princess Margaret Cancer Centre and Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 1L7 (Canada); Almlöf, Jonas [Department of Physics, Chemistry and Biology, Division of Chemistry, Linköping University, SE-58183 Linköping (Sweden); Li, Yanjun [Structural Genomics Consortium, University of Toronto, 101 College St, Toronto, Ontario M5G 1L7 (Canada); Yee, Adelinda [Princess Margaret Cancer Centre and Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 1L7 (Canada); Northeast Structural Genomics Consortium, Toronto, Ontario (Canada); Arrowsmith, Cheryl H. [Princess Margaret Cancer Centre and Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 1L7 (Canada); Northeast Structural Genomics Consortium, Toronto, Ontario (Canada); Structural Genomics Consortium, University of Toronto, 101 College St, Toronto, Ontario M5G 1L7 (Canada); Dhe-Paganon, Sirano [Structural Genomics Consortium, University of Toronto, 101 College St, Toronto, Ontario M5G 1L7 (Canada); Sunnerhagen, Maria, E-mail: maria.sunnerhagen@liu.se [Department of Physics, Chemistry and Biology, Division of Chemistry, Linköping University, SE-58183 Linköping (Sweden)

2014-04-25

Highlights: • We describe the structure of a novel fold in FKBP25 and HectD. • The new fold is named the Basic Tilted Helix Bundle (BTHB) domain. • A conserved basic surface patch is presented, suggesting a functional role. - Abstract: In this paper, we describe the structure of a N-terminal domain motif in nuclear-localized FKBP25{sub 1–73}, a member of the FKBP family, together with the structure of a sequence-related subdomain of the E3 ubiquitin ligase HectD1 that we show belongs to the same fold. This motif adopts a compact 5-helix bundle which we name the Basic Tilted Helix Bundle (BTHB) domain. A positively charged surface patch, structurally centered around the tilted helix H4, is present in both FKBP25 and HectD1 and is conserved in both proteins, suggesting a conserved functional role. We provide detailed comparative analysis of the structures of the two proteins and their sequence similarities, and analysis of the interaction of the proposed FKBP25 binding protein YY1. We suggest that the basic motif in BTHB is involved in the observed DNA binding of FKBP25, and that the function of this domain can be affected by regulatory YY1 binding and/or interactions with adjacent domains.

Basic properties of semiconductors

CERN Document Server

Landsberg, PT

2013-01-01

Since Volume 1 was published in 1982, the centres of interest in the basic physics of semiconductors have shifted. Volume 1 was called Band Theory and Transport Properties in the first edition, but the subject has broadened to such an extent that Basic Properties is now a more suitable title. Seven chapters have been rewritten by the original authors. However, twelve chapters are essentially new, with the bulk of this work being devoted to important current topics which give this volume an almost encyclopaedic form. The first three chapters discuss various aspects of modern band theory and the

Conformity Adequacy Review: Region 1

Science.gov (United States)

Resources are for air quality and transportation government and community leaders. Information on the adequacy/inadequacy of state implementation plans (SIPs) in EPA Region 1 (CT, ME, MA, NH, RI, VT) is provided here.

Family food purchases of high- and low-calorie foods in full-service supermarkets and other food retailers by Black women in an urban US setting.

Science.gov (United States)

Chrisinger, Benjamin W; DiSantis, Katherine Isselmann; Hillier, Amy E; Kumanyika, Shiriki K

2018-06-01

Public health interventions to increase supermarket access assume that shopping in supermarkets is associated with healthier food purchases compared to other store types. To test this assumption, we compared purchasing patterns by store-type for certain higher-calorie, less healthy foods (HCF) and lower-calorie, healthier foods (LCF) in a sample of 35 black women household shoppers in Philadelphia, PA. Data analyzed were from 450 food shopping receipts collected by these shoppers over four-week periods in 2012. We compared the likelihood of purchasing the HCF (sugar-sweetened beverages, sweet/salty snacks, and grain-based snacks) and LCF (low-fat dairy, fruits, and vegetables) at full-service supermarkets and six other types of food retailers, using generalized estimating equations. Thirty-seven percent of participants had household incomes at or below the poverty line, and 54% had a BMI >30. Participants shopped primarily at full-service supermarkets (55%) or discount/limited assortment supermarkets (22%), making an average of 11 shopping trips over a 4-week period and spending mean (SD) of $350 ($222). Of full-service supermarket receipts, 64% included at least one HCF item and 58% at least one LCF. Most trips including HCF (58%) and LCF (60%) expenditures were to full-service or discount/limited assortment supermarkets rather than smaller stores. Spending a greater percent of total dollars in full-service supermarkets was associated with spending more on HCF (p = 0.03) but not LCF items (p = 0.26). These findings in black women suggest a need for more attention to supermarket interventions that change retailing practices and/or consumer shopping behaviors related to foods in the HCF categories examined.

Selective removal of cesium from aqueous solutions with nickel (II) hexacyanoferrate (III) functionalized agricultural residue–walnut shell

Energy Technology Data Exchange (ETDEWEB)

Ding, Dahu, E-mail: dingdahu@gmail.com [Graduate School of Life and Environmental Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8572 (Japan); Lei, Zhongfang; Yang, Yingnan [Graduate School of Life and Environmental Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8572 (Japan); Feng, Chuanping [School of Water Resources and Environment, China University of Geosciences (Beijing), Key Laboratory of Groundwater Circulation and Evolution, Ministry of Education, Beijing 100083 (China); Zhang, Zhenya, E-mail: zhang.zhenya.fu@u.tsukuba.ac.jp [Graduate School of Life and Environmental Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8572 (Japan)

2014-04-01

Highlights: • Novel biosorbent for cesium removal was derived from agricultural residue. • It could remove cesium effectively from aqueous solution. • Large size of granules makes it easy to be separated from solutions. • The volume of used biosorbent could be significantly reduced after incineration. • Incinerated biosorbent has a low volume and a low cost final disposal. - Abstract: A novel nickel (II) hexacyanoferrate (III) functionalized agricultural residue-walnut shell (Ni{sup II}HCF{sup III}-WS) was developed to selectively remove cesium ion (Cs{sup +}) from aqueous solutions. This paper showed the first integral study on Cs{sup +} removal behavior and waste reduction analysis by using biomass adsorption material. The results indicated that the removal process was rapid and reached saturation within 2 h. As a special characteristic of Ni{sup II}HCF{sup III}-WS, acidic condition was preferred for Cs{sup +} removal, which was useful for extending the application scope of the prepared biomass material in treating acidic radioactive liquid waste. The newly developed Ni{sup II}HCF{sup III}-WS could selectively remove Cs{sup +} though the coexisting ions (Na{sup +} and K{sup +} in this study) exhibited negative effects. In addition, approximately 99.8% (in volume) of the liquid waste was reduced by using Ni{sup II}HCF{sup III}-WS and furthermore 91.9% (in volume) of the spent biomass material (Cs-Ni{sup II}HCF{sup III}-WS) was reduced after incineration (at 500 °C for 2 h). Due to its relatively high distribution coefficient and significant volume reduction, Ni{sup II}HCF{sup III}-WS is expected to be a promising material for Cs{sup +} removal in practice.

Pre-service teachers' mathematical knowledge for teaching basic ...

African Journals Online (AJOL)

This study measured pre-service teachers' mathematical knowledge for teaching (MKT) basic school mathematics. MKT multiple-choice test was administered to 100 pre-service teachers from two colleges of education (located at Mampong in the Ashanti Region of Ghana) to assess their mathematical knowledge for ...

ATLAS Transition Region Upgrade at Phase-1

CERN Document Server

Song, H; The ATLAS collaboration

2014-01-01

This report presents the L1 Muon trigger transition region (1.0<|ƞ|<1.3) upgrade of ATLAS Detector at phase-1. The high fake trigger rate in the Endcap region 1.0<|ƞ|<2.4 would become a serious problem for the ATLAS L1 Muon trigger system at high luminosity. For the region 1.3<|ƞ|<2.4, covered by the Small Wheel, ATLAS is enhancing the present muon trigger by adding local fake rejection and track angle measurement capabilities. To reduce the rate in the remaining ƞ interval it has been proposed a similar enhancement by adding at the edge of the inner barrel a structure of 3-layers RPCs of a new generation. These RPCs will be based on a thinner gas gap and electrodes with respect to the ATLAS standards, a new high performance Front End, integrating fast TDC capabilities, and a new low profile and light mechanical structure allowing the installation in the tiny space available.This design effectively suppresses fake triggers by making the coincidence with both end-cap and interaction point...

Accessibility Inequality to Basic Education in Amhara Region, Ethiopia

African Journals Online (AJOL)

owner

educational services in Amhara region of Ethiopia in terms of availability and accessibility ... Dept. of Geography Bahir Dar University Bahir Dar, Ethiopia ... and very high students / teacher ratio. .... facilities to train their children (Hanmer et ...

Basic calcium phosphate crystal-induced Egr-1 expression stimulates mitogenesis in human fibroblasts

International Nuclear Information System (INIS)

Zeng, Xiao R.; Sun Yubo; Wenger, Leonor; Cheung, Herman S.

2005-01-01

Previously, we have reported that basic calcium phosphate (BCP) crystals stimulate mitogenesis and synthesis of matrix metalloproteinases in cultured human foreskin and synovial fibroblasts. However, the detailed mechanisms involved are still unclear. In the present study, using RT-PCR and Egr-1 promoter analysis we showed that BCP crystals could stimulate early growth response gene Egr-1 transcription through a PKCα-dependent p44/p42 MAPK pathway. Using a retrovirus gene expression system (Clontech) to overexpress Egr-1 in human fibroblast BJ-1 cells resulted in promotion of mitogenesis measured either by MTT cell proliferation analysis or by direct cell counting. The results demonstrate that Egr-1 may play a key role in mediating BCP crystal-induced synovial fibroblast mitogenesis

Active region structures in the transition region and corona

International Nuclear Information System (INIS)

Webb, D.F.

1981-01-01

Observational aspects of the transition region and coronal structures of the solar active region are reviewed with an emphasis on imaging of the plasma loops which act as tracers of the magnetic flux loops. The study of the basic structure of an active region is discussed in terms of the morphological and thermal classifications of active region loops, including umbral structures, and observational knowledge of the thermal structure of loops is considered in relation to scaling laws, emission measures and the structures of individual loops. The temporal evolution of active region loop structures is reviewed with emphasis on ephemeral regions and the emergence of active regions. Planned future spaceborne observations of active region loop structures in the EUV and soft X-ray regions are also indicated

Hygiene Basics

Science.gov (United States)

... Staying Safe Videos for Educators Search English Español Hygiene Basics KidsHealth / For Teens / Hygiene Basics What's in this article? Oily Hair Sweat ... smell, anyway? Read below for information on some hygiene basics — and learn how to deal with greasy ...

Basic Design Study on 1-MV Electrostatic Accelerator for ion irradiation

International Nuclear Information System (INIS)

Cho, Yongsub; Kim, Kyeryung; Lee, Chanyoung

2014-01-01

The KOMAC (KOrea Multi-purpose Accelerator Complex) has electrostatic ion accelerators whose terminal voltages are less than 100kV. To extend ion beam irradiations with higher energy ions for industrial purposes, an electrostatic accelerator of 1-MV terminal voltage should have been studied. For industrial applications, the most important features of the accelerator are high current and high reliability for high irradiation dose and high through-put with high current and long irradiation time. The basic study on 1-MV electrostatic ion accelerator for industrial applications has been done. The key components are a high voltage power supply, an ion source, and an accelerating column. The feasibility study for fabrication is being performed. Especially the R and D for ion source is required. The 1-MV ion accelerator will be constructed with domestic companies and installed in the beam application research building, which is under construction in the site of KOMAC at Gyeongju

Nickel Hexacyanoferrate Nanoparticles as a Low Cost Cathode Material for Lithium-Ion Batteries

International Nuclear Information System (INIS)

Omarova, Marzhana; Koishybay, Aibolat; Yesibolati, Nulati; Mentbayeva, Almagul; Umirov, Nurzhan; Ismailov, Kairat; Adair, Desmond; Babaa, Moulay-Rachid; Kurmanbayeva, Indira; Bakenov, Zhumabay

2015-01-01

Potassium nickel hexacyanoferrate KNi[Fe(CN) 6 ] (NiHCF) was synthesized by a simple co-precipitation method and investigated as a cathode material for lithium-ion batteries. The X-ray diffraction and transmission electron microscopy studies revealed the formation of pure phase of agglomerated NiHCF nanoparticles of about 20–50 nm in size. The material exhibited stable cycling performance as a cathode in a lithium half-cell within a wide range of current densities, and a working potential around 3.3 V vs. Li + /Li. The lithium ion diffusion coefficient in this system was determined to be in a range of 10 −9 to 10 −8 cm 2 s −1 , which is within the values for the cathode materials for lithium-ion batteries with high rate capability. Considering promising electrochemical performance and attractive lithium-ion diffusion properties of this material along with its economical benefits and simplified preparation, NiHCF could be considered as a very promising cathode for large scale lithium-ion batteries.

The Role of Titanium Surface Microtopography on Adhesion, Proliferation, Transformation, and Matrix Deposition of Corneal Cells.

Science.gov (United States)

Zhou, Chengxin; Lei, Fengyang; Chodosh, James; Paschalis, Eleftherios I

2016-04-01

Titanium (Ti) is an excellent implantable biomaterial that can be further enhanced by surface topography optimization. Despite numerous data from orthopedics and dentistry, the effect of Ti surface topography on ocular cells is still poorly understood. In light of the recent adaptation of Ti in the Boston Keratoprosthesis artificial cornea, we attempted to perform an extended evaluation of the effect of Ti surface topography on corneal cell adhesion, proliferation, cytotoxicity, transformation, and matrix deposition. Different surface topographies were generated on medical grade Ti-6Al-4V-ELI (extra-low interstitial), with linearly increased roughness (polished to grit blasted). Biological response was evaluated in vitro using human corneal limbal epithelial (HCLE) cells, stromal fibroblasts (HCF), and endothelial cells (HCEnC). None of the Ti surface topographies caused cytotoxicity to any of the three corneal cell types. However, rough Ti surface inhibited HCLE and HCF cell adhesion and proliferation, while HCEnC proliferation was unaffected. Long-term experiments with HCF revealed that rough Ti surface with R(a) (the arithmetic average of the profile height from the mean line) ≥ 1.15 μm suppressed HCF focal adhesion kinase phosphorylation, changed fibroblast morphology, and caused less aligned and reduced deposition of collagen matrix as compared to smooth Ti (R(a) ≤ 0.08 μm). In the presence of transforming growth factor β1 (TGFβ1) stimulation, rough Ti inhibited alpha-smooth muscle actin (α-SMA) expression and collagen deposition, leading to decreased myofibroblast transformation and disorganization of the collagen fibrils as compared to smooth Ti. This study suggests that Ti surface topography regulates corneal cell behavior in a tissue-dependent manner that varies across the corneal strata. Contrary to the accepted paradigm, smooth surface topography can enhance cell adhesion and proliferation and increase matrix deposition by corneal cells.

Effect of a Brazilian regional basic diet on the prevalence of caries in rats.

Science.gov (United States)

Pinheiro, J T; Couto, G B L; Vasconcelos, M M V B; Melo, M M D C; Guedes, R C A; Cordeiro, M A C

2002-07-01

The aim of the present study was to determine the effect of a regional basic diet (RBD) on the prevalence of caries in the molar teeth of rats of both sexes aged 23 days. The animals were divided into six groups of 10 rats each receiving the following diets for 30 and 60 days after weaning: RBD, a cariogenic diet, and a commercial diet. The prevalence and penetration of caries in the molar teeth of the rats was then analyzed. The RBD produced caries in 37.5% of the teeth of animals fed 30 days, and in 83.4% of animals fed 60 days, while the cariogenic diet produced caries in 72.5% and 77.5% of the teeth of animals fed 30 and 60 days, respectively. Rats fed the RBD for 30 days had caries in the enamel in 38% of their teeth, 48% had superficial dentin caries, and 7.5% moderate dentin caries. The effect of the RBD did not differ significantly from that of the cariogenic diet in terms of the presence of caries in rats fed 60 days. The penetration depth of the caries produced by the RBD was the same as that produced by the cariogenic diet. Our results show that the RBD has the same cariogenic potential as the cariogenic diet. Since the RBD is the only option for the low-income population, there should be a study of how to compensate for the cariogenicity of this diet.

Effect of a Brazilian regional basic diet on the prevalence of caries in rats

Directory of Open Access Journals (Sweden)

J.T. Pinheiro

2002-07-01

Full Text Available The aim of the present study was to determine the effect of a regional basic diet (RBD on the prevalence of caries in the molar teeth of rats of both sexes aged 23 days. The animals were divided into six groups of 10 rats each receiving the following diets for 30 and 60 days after weaning: RBD, a cariogenic diet, and a commercial diet. The prevalence and penetration of caries in the molar teeth of the rats was then analyzed. The RBD produced caries in 37.5% of the teeth of animals fed 30 days, and in 83.4% of animals fed 60 days, while the cariogenic diet produced caries in 72.5% and 77.5% of the teeth of animals fed 30 and 60 days, respectively. Rats fed the RBD for 30 days had caries in the enamel in 38% of their teeth, 48% had superficial dentin caries, and 7.5% moderate dentin caries. The effect of the RBD did not differ significantly from that of the cariogenic diet in terms of the presence of caries in rats fed 60 days. The penetration depth of the caries produced by the RBD was the same as that produced by the cariogenic diet. Our results show that the RBD has the same cariogenic potential as the cariogenic diet. Since the RBD is the only option for the low-income population, there should be a study of how to compensate for the cariogenicity of this diet.

Basic Physics for Nuclear Medicine. Chapter 1

Energy Technology Data Exchange (ETDEWEB)

Podgorsak, E. B. [Department of Medical Physics, McGill University, Montreal (Canada); Kesner, A. L. [Division of Human Health, International Atomic Energy Agency, Vienna (Austria); Soni, P. S. [Medical Cyclotron Facility, Board of Radiation and Isotope Technology, Bhabha Atomic Research Centre, Mumbai (India)

2014-12-15

The technologies used in nuclear medicine for diagnostic imaging have evolved over the last century, starting with Röntgen’s discovery of X rays and Becquerel’s discovery of natural radioactivity. Each decade has brought innovation in the form of new equipment, techniques, radiopharmaceuticals, advances in radionuclide production and, ultimately, better patient care. All such technologies have been developed and can only be practised safely with a clear understanding of the behaviour and principles of radiation sources and radiation detection. These central concepts of basic radiation physics and nuclear physics are described in this chapter and should provide the requisite knowledge for a more in depth understanding of the modern nuclear medicine technology discussed in subsequent chapters.

Predictive validity of the comprehensive basic science examination mean score for assessment of medical students' performance

Directory of Open Access Journals (Sweden)

Firouz Behboudi

2002-04-01

Full Text Available Background Medical education curriculum improvements can be achieved bye valuating students performance. Medical students have to pass two undergraduate comprehensive examinations, basic science and preinternship, in Iran. Purpose To measure validity of the students' mean score in comprehensive basic science exam (CBSE for predicting their performance in later curriculum phases. Methods This descriptive cross-sectional study was conducted on 95 (38 women and 55 men Guilan medical university students. Their admission to the university was 81% by regional quota and 12% by shaheed and other organizations' share. They first enrolled in 1994 and were able to pass CBS£ at first try. Data on gender, regional quota, and average grades of CBS£, PC, and CPIE were collected by a questionnaire. The calculations were done by SPSS package. Results The correlation coefficient between CBS£ and CPIE mean scores (0.65 was higher than correlation coefficient between CBS£ and PC mean scores (0.49. The predictive validity of CBS£ average grade was significant for students' performance in CPIE; however, the predictive validity of CBSE mean scores for students I pe1jormance in PC was lower. Conclusion he students' mean score in CBSE can be a good denominator for their further admission. We recommend further research to assess the predictive validity for each one of the basic courses. Keywords predictive validity, comprehensive basic exam

Effect of chest compressions only during experimental basic life support on alveolar collapse and recruitment.

Science.gov (United States)

Markstaller, Klaus; Rudolph, Annette; Karmrodt, Jens; Gervais, Hendrik W; Goetz, Rolf; Becher, Anja; David, Matthias; Kempski, Oliver S; Kauczor, Hans-Ulrich; Dick, Wolfgang F; Eberle, Balthasar

2008-10-01

The importance of ventilatory support during cardiac arrest and basic life support is controversial. This experimental study used dynamic computed tomography (CT) to assess the effects of chest compressions only during cardiopulmonary resuscitation (CCO-CPR) on alveolar recruitment and haemodynamic parameters in porcine model of ventricular fibrillation. Twelve anaesthetized pigs (26+/-1 kg) were randomly assigned to one of the following groups: (1) intermittent positive pressure ventilation (IPPV) both during basic life support and advanced cardiac life support, or (2) CCO during basic life support and IPPV during advanced cardiac life support. Measurements were acquired at baseline prior to cardiac arrest, during basic life support, during advanced life support, and after return of spontaneous circulation (ROSC), as follows: dynamic CT series, arterial and central venous pressures, blood gases, and regional organ blood flow. The ventilated and atelectatic lung area was quantified from dynamic CT images. Differences between groups were analyzed using the Kruskal-Wallis test, and a pbasic life support in the CCO-CPR group remained clinically relevant throughout the subsequent advanced cardiac life support period and following ROSC, and was associated with prolonged impaired haemodynamics. No inter-group differences in myocardial and cerebral blood flow were observed. A lack of ventilation during basic life support is associated with excessive atelectasis, arterial hypoxaemia and compromised CPR haemodynamics. Moreover, these detrimental effects remain evident even after restoration of IPPV.

The Arabidopsis GAGA-Binding Factor BASIC PENTACYSTEINE6 Recruits the POLYCOMB-REPRESSIVE COMPLEX1 Component LIKE HETEROCHROMATIN PROTEIN1 to GAGA DNA Motifs.

Science.gov (United States)

Hecker, Andreas; Brand, Luise H; Peter, Sébastien; Simoncello, Nathalie; Kilian, Joachim; Harter, Klaus; Gaudin, Valérie; Wanke, Dierk

2015-07-01

Polycomb-repressive complexes (PRCs) play key roles in development by repressing a large number of genes involved in various functions. Much, however, remains to be discovered about PRC-silencing mechanisms as well as their targeting to specific genomic regions. Besides other mechanisms, GAGA-binding factors in animals can guide PRC members in a sequence-specific manner to Polycomb-responsive DNA elements. Here, we show that the Arabidopsis (Arabidopsis thaliana) GAGA-motif binding factor protein basic pentacysteine6 (BPC6) interacts with like heterochromatin protein1 (LHP1), a PRC1 component, and associates with vernalization2 (VRN2), a PRC2 component, in vivo. By using a modified DNA-protein interaction enzyme-linked immunosorbant assay, we could show that BPC6 was required and sufficient to recruit LHP1 to GAGA motif-containing DNA probes in vitro. We also found that LHP1 interacts with VRN2 and, therefore, can function as a possible scaffold between BPC6 and VRN2. The lhp1-4 bpc4 bpc6 triple mutant displayed a pleiotropic phenotype, extreme dwarfism and early flowering, which disclosed synergistic functions of LHP1 and group II plant BPC members. Transcriptome analyses supported this synergy and suggested a possible function in the concerted repression of homeotic genes, probably through histone H3 lysine-27 trimethylation. Hence, our findings suggest striking similarities between animal and plant GAGA-binding factors in the recruitment of PRC1 and PRC2 components to Polycomb-responsive DNA element-like GAGA motifs, which must have evolved through convergent evolution. © 2015 American Society of Plant Biologists. All Rights Reserved.

China Dimensions Data Collection: China Administrative Regions GIS Data: 1:1M, County Level, 1 July 1990

Data.gov (United States)

National Aeronautics and Space Administration — China Administrative Regions GIS Data: 1:1M, County Level, 1 July 1990 consists of geographic boundary data for the administrative regions of China as of 1 July...

Family food purchases of high- and low-calorie foods in full-service supermarkets and other food retailers by Black women in an urban US setting

Directory of Open Access Journals (Sweden)

Benjamin W. Chrisinger

2018-06-01

Full Text Available Public health interventions to increase supermarket access assume that shopping in supermarkets is associated with healthier food purchases compared to other store types. To test this assumption, we compared purchasing patterns by store-type for certain higher-calorie, less healthy foods (HCF and lower-calorie, healthier foods (LCF in a sample of 35 black women household shoppers in Philadelphia, PA. Data analyzed were from 450 food shopping receipts collected by these shoppers over four-week periods in 2012. We compared the likelihood of purchasing the HCF (sugar-sweetened beverages, sweet/salty snacks, and grain-based snacks and LCF (low-fat dairy, fruits, and vegetables at full-service supermarkets and six other types of food retailers, using generalized estimating equations. Thirty-seven percent of participants had household incomes at or below the poverty line, and 54% had a BMI >30. Participants shopped primarily at full-service supermarkets (55% or discount/limited assortment supermarkets (22%, making an average of 11 shopping trips over a 4-week period and spending mean (SD of $350 ($222. Of full-service supermarket receipts, 64% included at least one HCF item and 58% at least one LCF. Most trips including HCF (58% and LCF (60% expenditures were to full-service or discount/limited assortment supermarkets rather than smaller stores. Spending a greater percent of total dollars in full-service supermarkets was associated with spending more on HCF (p = 0.03 but not LCF items (p = 0.26. These findings in black women suggest a need for more attention to supermarket interventions that change retailing practices and/or consumer shopping behaviors related to foods in the HCF categories examined. Keywords: Obesity, Store choice, Food choice, Food shopping, Supermarkets, African Americans

Ciclo Basico Polivalente (Basic Comprehensive Courses of Study).

Science.gov (United States)

Boletin del Centro Nacional de Documentacion e Informacion Educativa, 1970

1970-01-01

This article discusses the creation of comprehensive secondary schools in Argentina to meet the diversified goals of the population in any given geographical region. The plan described here provides for the creation of several basic-study cycles within one school so that students may pursue courses in commercial, technical, and academic fields.…

Table S1 Basic characteristics of 32 SNPs of neurotransmitter ...

Indian Academy of Sciences (India)

微软用户

Basic characteristics of 32 SNPs in neurotransmitter-related genes. Gene .... rs45435444, rs80837467 and rs80980072, significant differences (P. *** * ... At the same age and environments, skin lesion scores on the ears (P < 0.001), front (P <.

EPA Region 1 Coast Guard Jurisdictional Boundary - Polygons

Science.gov (United States)

Jurisdictional boundary between EPA and Coast Guard for EPA Region I. Created from 1:100000 USGS DLGs with greater detail drawn from 1:24000 commercial street data for Region I.This layer is used to determine which agency will be reponsible in the event of an oil spill.

EPA Region 1 Coast Guard Jurisdictional Boundary - Arcs

Science.gov (United States)

Jurisdictional boundary between EPA and Coast Guard for EPA Region I. Created from 1:100000 USGS DLGs with greater detail drawn from 1:24000 commercial street data for Region I.This layer is used to determine which agency will be reponsible in the event of an oil spill.

Basic Graphical Data Management System (BAGDAMS version 1.0)

International Nuclear Information System (INIS)

Weindorf, J.W.

1979-06-01

BAGDAMS (BAsic Graphical DAta Management System) is a set of FORTRAN callable subroutines which provides mass storage data structuring and manipulation capabilities. Although primarily designed to facilitate the handling of graphical data files (files containing information to be displayed upon graphical hardware devices), BAGDAMS can also be used in many other applications requiring complex mass storage resident data structures. (author)

Investigation of health care waste management in Binzhou District, China

International Nuclear Information System (INIS)

Ruoyan, Gai; Xu Lingzhong; Li Huijuan; Zhou Chengchao; He Jiangjiang; Yoshihisa, Shirayama; Tang Wei; Chushi, Kuroiwa

2010-01-01

In China, national regulations and standards for health care waste management were implemented in 2003. To investigate the current status of health care waste management at different levels of health care facilities (HCF) after the implementation of these regulations, one tertiary hospital, one secondary hospital, and four primary health care centers from Binzhou District were visited and 145 medical staff members and 24 cleaning personnel were interviewed. Generated medical waste totaled 1.22, 0.77, and 1.17 kg/bed/day in tertiary, secondary, and primary HCF, respectively. The amount of medical waste generated in primary health care centers was much higher than that in secondary hospitals, which may be attributed to general waste being mixed with medical waste. This study found that the level of the HCF, responsibility for medical waste management in departments and wards, educational background and training experience can be factors that determine medical staff members' knowledge of health care waste management policy. Regular training programs and sufficient provision of protective measures are urgently needed to improve occupational safety for cleaning personnel. Financing and administrative monitoring by local authorities is needed to improve handling practices and the implementation of off-site centralized disposal in primary health care centers.

32 CFR 37.1240 - Basic research.

Science.gov (United States)

2010-07-01

... 32 National Defense 1 2010-07-01 2010-07-01 false Basic research. 37.1240 Section 37.1240 National... TECHNOLOGY INVESTMENT AGREEMENTS Definitions of Terms Used in This Part § 37.1240 Basic research. Efforts... practical application of that knowledge and understanding. It typically is funded within Research...

5 CFR 551.401 - Basic principles.

Science.gov (United States)

2010-01-01

... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Basic principles. 551.401 Section 551.401 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PAY ADMINISTRATION UNDER THE FAIR LABOR STANDARDS ACT Hours of Work General Provisions § 551.401 Basic principles. (a) All time...

Fiscal 2000 basic survey report for vision formulation. Regional new energy vision for Sabae city, Fukui prefecture; Sabaeshi chiiki shin energy vision. 2000 nendo sakutei kiso chosa hokokusho

Energy Technology Data Exchange (ETDEWEB)

NONE

2001-03-01

Sabae city, Fukui Prefecture, has worked out a regional new energy vision for which the inhabitants, industrialists, and administrators combined their efforts to build a daily life related culture, friendly to environments and peculiar to the locality. The fruits of their activities are summarized in five chapters, which are (1) the basic philosophy, (2) survey of the amounts of new energy in existence, (3) survey of the amount of energy demanded, (4) various surveys conducted with the participation of the citizenry, (5) and summarization of important topics. Discussed in chapter (2) is the basic policy toward reckoning the amounts of new energy in existence, such as photovoltaic energy, solar heat energy, wind energy, hydraulic energy, temperature difference energy, and other energy resources remaining to be utilized. It states that they, when converted into electric power, 2.0 times 10{sup 8} kWh/year will be available and, when converted into heat energy, 2.92 times 10{sup 11} kcal/year will be available, accounting for approximately 30% of the city's energy consumption. When the energy resources are broken down by type, it is found that solar energy, wind energy, and refuse-derived energy are in existence aplenty. (NEDO)

Forecasting global developments in the basic chemical industry for environmental policy analysis

International Nuclear Information System (INIS)

Broeren, M.L.M.; Saygin, D.; Patel, M.K.

2014-01-01

The chemical sector is the largest industrial energy user, but detailed analysis of its energy use developments lags behind other energy-intensive sectors. A cost-driven forecasting model for basic chemicals production is developed, accounting for regional production costs, demand growth and stock turnover. The model determines the global production capacity placement, implementation of energy-efficient Best Practice Technology (BPT) and global carbon dioxide (CO 2 ) emissions for the period 2010–2030. Subsequently, the effects of energy and climate policies on these parameters are quantified. About 60% of new basic chemical production capacity is projected to be placed in non-OECD regions by 2030 due to low energy prices. While global production increases by 80% between 2010 and 2030, the OECD's production capacity share decreases from 40% to 20% and global emissions increase by 50%. Energy pricing and climate policies are found to reduce 2030 CO 2 emissions by 5–15% relative to the baseline developments by increasing BPT implementation. Maximum BPT implementation results in a 25% reduction. Further emission reductions require measures beyond energy-efficient technologies. The model is useful to estimate general trends related to basic chemicals production, but improved data from the chemical sector is required to expand the analysis to additional technologies and chemicals. - Highlights: • We develop a global cost-driven forecasting model for the basic chemical sector. • We study regional production, energy-efficient technology, emissions and policies. • Between 2010 and 2030, 60% of new chemicals capacity is built in non-OECD regions. • Global CO 2 emissions rise by 50%, but climate policies may limit this to 30–40%. • Measures beyond energy efficiency are needed to prevent increasing CO 2 emissions

Basic Services for All in an Urbanizing World: GOLD III

Directory of Open Access Journals (Sweden)

Claire Frost

2014-07-01

Full Text Available Basic Services for All in an Urbanizing World is the third instalment in United Cities and Local Government’s (UCLG flagship series of global reports on local democracy and decentralisation (GOLD III. In the context of rapid urbanisation, climate change and economic uncertainty the report is an impressive attempt to analyse local government’s role in the provision of basic services, the challenges they are facing, and make recommendations to improve local government’s ability to ensure access for all. Published in 2014, the report is well positioned to feed into the current debate on what will follow the UN Millennium Development Goals, and examines the role of local government in the provision of basic services across the world regions.

The D1 parameter for the equatorial F1 region

International Nuclear Information System (INIS)

Adeniyi, J.O.; Radicella, S.M.

2002-01-01

This work is a contribution to the effort at improving the representation of the F1 equatorial ionospheric region in the International Reference Ionosphere (IRI) model. The D1 parameter has been proposed for describing the F1 layer. We have therefore produced a maiden table of D1 parameter for an equatorial station. Diurnal and seasonal effects were considered. (author)

Basic characterization of normal multifocal electroretinogram

International Nuclear Information System (INIS)

Fernandez Cherkasova, Lilia; Rojas Rondon, Irene; Castro Perez, Pedro Daniel; Lopez Felipe, Daniel; Santiesteban Freixas, Rosaralis; Mendoza Santiesteban, Carlos E

2008-01-01

A scientific literature review was made on the novel multifocal electroretinogram technique, the involved cell mechanisms and some of the factors modifying its results together with the form of presentation. The basic characteristics of this electrophysiological record obtained from several regions of the retina of normal subjects is important in order to create at a small scale a comparative database to evaluate pathological eye tracing. All this will greatly help in early less invasive electrodiagnosis of localized retinal lesions. (Author)

The Solomon Sea eddy activity from a 1/36° regional model

Science.gov (United States)

Djath, Bughsin; Babonneix, Antoine; Gourdeau, Lionel; Marin, Frédéric; Verron, Jacques

2013-04-01

In the South West Pacific, the Solomon Sea exhibits the highest levels of eddy kinetic energy but relatively little is known about the eddy activity in this region. This Sea is directly influenced by a monsoonal regime and ENSO variability, and occupies a strategical location as the Western Boundary Currents exiting it are known to feed the warm pool and to be the principal sources of the Equatorial UnderCurrent. During their transit in the Solomon Sea, meso-scale eddies are suspected to notably interact and influence these water masses. The goal of this study is to give an exhaustive description of this eddy activity. A dual approach, based both on altimetric data and high resolution modeling, has then been chosen for this purpose. First, an algorithm is applied on nearly 20 years of 1/3° x 1/3° gridded SLA maps (provided by the AVISO project). This allows eddies to be automatically detected and tracked, thus providing some basic eddy properties. The preliminary results show that two main and distinct types of eddies are detected. Eddies in the north-eastern part shows a variability associated with the mean structure, while those in the southern part are associated with generation/propagation processes. However, the resolution of the AVISO dataset is not very well suited to observe fine structures and to match with the numerous islands bordering the Solomon Sea. For this reason, we will confront these observations with the outputs of a 1/36° resolution realistic model of the Solomon Sea. The high resolution numerical model (1/36°) indeed permits to reproduce very fine scale features, such as eddies and filaments. The model is two-way embedded in a 1/12° regional model which is itself one-way embedded in the DRAKKAR 1/12° global model. The NEMO code is used as well as the AGRIF software for model nestings. Validation is realized by comparison with AVISO observations and available in situ data. In preparing the future wide-swath altimetric SWOT mission that is

Wavelet basics

CERN Document Server

Chan, Y T

1995-01-01

Since the study of wavelets is a relatively new area, much of the research coming from mathematicians, most of the literature uses terminology, concepts and proofs that may, at times, be difficult and intimidating for the engineer. Wavelet Basics has therefore been written as an introductory book for scientists and engineers. The mathematical presentation has been kept simple, the concepts being presented in elaborate detail in a terminology that engineers will find familiar. Difficult ideas are illustrated with examples which will also aid in the development of an intuitive insight. Chapter 1 reviews the basics of signal transformation and discusses the concepts of duals and frames. Chapter 2 introduces the wavelet transform, contrasts it with the short-time Fourier transform and clarifies the names of the different types of wavelet transforms. Chapter 3 links multiresolution analysis, orthonormal wavelets and the design of digital filters. Chapter 4 gives a tour d'horizon of topics of current interest: wave...

Basic research on maxillofacial implants

International Nuclear Information System (INIS)

Matsui, Yoshiro

2001-01-01

Osseointegrated implants have begun to be used not only in general practice in dentistry but also in various clinical situations in the maxillofacial region. The process has yielded three problems: the spread of application, new materials and diagnostic methods, and management for difficult situations. This paper presents basic data and clinical guidelines for new applications, it investigates the characteristics of the materials and the usefulness of a new diagnostic method, and it studies effective techniques for difficult cases. The results obtained are as follows: Investigations into the spreading application. The lateral and superior orbital rim have sufficient bone thickness and width for the implant body to be placed. Osseointegrated implants, especially by the fixed bridge technique, are not recommended in the craniofacial bone and jaws of young children. Implant placement into bone after/before irradiation must be performed in consideration of impaired osteogenesis, the decrease of trabecular bone, and the time interval between implantation and irradiation. Investigations into materials and diagnostic methods. Hydroxyapatite-coated and titanium implants should be selected according to the characteristics of the materials. A dental simulating soft may also be applicable in the craniofacial region. Investigations into the management of difficult cases. Hyperbaric oxygen therapy (HBO), bone morphogenetic protein (BMP), and tissue engineering should be useful for improving the quality and increasing the quantity of bone where implants are placed. Soft tissue around implants placed in the reconstructed area should be replaced with mucosal tissue. The data obtained here should be useful for increasing the efficiency of osseointegrated implants, but further basic research is required in the future. (author)

Basic research on maxillofacial implants

Energy Technology Data Exchange (ETDEWEB)

Matsui, Yoshiro [Showa Univ., Tokyo (Japan). School of Dentistry

2001-11-01

Osseointegrated implants have begun to be used not only in general practice in dentistry but also in various clinical situations in the maxillofacial region. The process has yielded three problems: the spread of application, new materials and diagnostic methods, and management for difficult situations. This paper presents basic data and clinical guidelines for new applications, it investigates the characteristics of the materials and the usefulness of a new diagnostic method, and it studies effective techniques for difficult cases. The results obtained are as follows: Investigations into the spreading application. The lateral and superior orbital rim have sufficient bone thickness and width for the implant body to be placed. Osseointegrated implants, especially by the fixed bridge technique, are not recommended in the craniofacial bone and jaws of young children. Implant placement into bone after/before irradiation must be performed in consideration of impaired osteogenesis, the decrease of trabecular bone, and the time interval between implantation and irradiation. Investigations into materials and diagnostic methods. Hydroxyapatite-coated and titanium implants should be selected according to the characteristics of the materials. A dental simulating soft may also be applicable in the craniofacial region. Investigations into the management of difficult cases. Hyperbaric oxygen therapy (HBO), bone morphogenetic protein (BMP), and tissue engineering should be useful for improving the quality and increasing the quantity of bone where implants are placed. Soft tissue around implants placed in the reconstructed area should be replaced with mucosal tissue. The data obtained here should be useful for increasing the efficiency of osseointegrated implants, but further basic research is required in the future. (author)

Bayesian near-boundary analysis in basic macroeconomic time series models

NARCIS (Netherlands)

M.D. de Pooter (Michiel); F. Ravazzolo (Francesco); R. Segers (René); H.K. van Dijk (Herman)

2008-01-01

textabstractSeveral lessons learnt from a Bayesian analysis of basic macroeconomic time series models are presented for the situation where some model parameters have substantial posterior probability near the boundary of the parameter region. This feature refers to near-instability within dynamic

Stem Cell Basics

Science.gov (United States)

... Tips Info Center Research Topics Federal Policy Glossary Stem Cell Information General Information Clinical Trials Funding Information Current ... Basics » Stem Cell Basics I. Back to top Stem Cell Basics I. Introduction: What are stem cells, and ...

Water masers in NGC7538 region

Science.gov (United States)

Kameya, Osamu

We observed H2O masers towards NGC7538 molecular-cloud core using VERA (VLBI Experiment of Radio Astrometry). This region is in the Perseus arm at a distance of about 2.7 kpc and is famous for its multiple, massive star formation. There are three areas there, N(IRS1-3), E(IRS9), and S(IRS11), each having a strong IR source(s), ultra-compact HII region(s), bipolar outflow, high-density core, and OH/H2O/CH3OH masers. We made differential VLBI observations towards the NGC7538 H2O maser sources at N and S and a reference source, Cepheus A H2O maser, simultaneously. The Cepheus A region is separated by 2 degrees from the NGC7538 region. The positions of H2O masers in N and S regions, distributed around the ultra-compact HII regions, are basically consistent with those found by means of interferometric observations of past 29 years. The masers may come from interface regions between the ultra-compact HII regions and the environments of dense molecular gas.

Basic visual function and cortical thickness patterns in posterior cortical atrophy.

Science.gov (United States)

Lehmann, Manja; Barnes, Josephine; Ridgway, Gerard R; Wattam-Bell, John; Warrington, Elizabeth K; Fox, Nick C; Crutch, Sebastian J

2011-09-01

Posterior cortical atrophy (PCA) is characterized by a progressive decline in higher-visual object and space processing, but the extent to which these deficits are underpinned by basic visual impairments is unknown. This study aimed to assess basic and higher-order visual deficits in 21 PCA patients. Basic visual skills including form detection and discrimination, color discrimination, motion coherence, and point localization were measured, and associations and dissociations between specific basic visual functions and measures of higher-order object and space perception were identified. All participants showed impairment in at least one aspect of basic visual processing. However, a number of dissociations between basic visual skills indicated a heterogeneous pattern of visual impairment among the PCA patients. Furthermore, basic visual impairments were associated with particular higher-order object and space perception deficits, but not with nonvisual parietal tasks, suggesting the specific involvement of visual networks in PCA. Cortical thickness analysis revealed trends toward lower cortical thickness in occipitotemporal (ventral) and occipitoparietal (dorsal) regions in patients with visuoperceptual and visuospatial deficits, respectively. However, there was also a lot of overlap in their patterns of cortical thinning. These findings suggest that different presentations of PCA represent points in a continuum of phenotypical variation.

Basic research for environmental restoration

International Nuclear Information System (INIS)

1990-12-01

The Department of Energy (DOE) is in the midst of a major environmental restoration effort to reduce the health and environmental risks resulting from past waste management and disposal practices at DOE sites. This report describes research needs in environmental restoration and complements a previously published document, DOE/ER-0419, Evaluation of Mid-to-Long Term Basic Research for Environmental Restoration. Basic research needs have been grouped into five major categories patterned after those identified in DOE/ER-0419: (1) environmental transport and transformations; (2) advanced sampling, characterization, and monitoring methods; (3) new remediation technologies; (4) performance assessment; and (5) health and environmental effects. In addition to basic research, this document deals with education and training needs for environmental restoration. 2 figs., 6 tabs

Basic research for environmental restoration

Energy Technology Data Exchange (ETDEWEB)

1990-12-01

The Department of Energy (DOE) is in the midst of a major environmental restoration effort to reduce the health and environmental risks resulting from past waste management and disposal practices at DOE sites. This report describes research needs in environmental restoration and complements a previously published document, DOE/ER-0419, Evaluation of Mid-to-Long Term Basic Research for Environmental Restoration. Basic research needs have been grouped into five major categories patterned after those identified in DOE/ER-0419: (1) environmental transport and transformations; (2) advanced sampling, characterization, and monitoring methods; (3) new remediation technologies; (4) performance assessment; and (5) health and environmental effects. In addition to basic research, this document deals with education and training needs for environmental restoration. 2 figs., 6 tabs.

Basics concepts and clinical applications of oxygen-enhanced MR imaging

International Nuclear Information System (INIS)

Ohno, Yoshiharu; Hatabu, Hiroto

2007-01-01

Oxygen-enhanced MR imaging is a new technique, and its physiological significance has not yet been fully elucidated. This review article covers (1) the theory of oxygen enhancement and its relationship with respiratory physiology; (2) design for oxygen-enhanced MR imaging sequencing; (3) a basic study of oxygen-enhanced MR imaging in animal models and humans; (4) a clinical study of oxygen-enhanced MR imaging; and (5) a comparison of advantages and disadvantages of this technique with those of hyperpolarized noble gas MR ventilation imaging. Oxygen-enhanced MR imaging provides not only the ventilation-related, but also respiration-related information. Oxygen-enhanced MR imaging has the potential to replace nuclear medicine studies for the identification of regional pulmonary function, and many investigators are now attempting to adapt this technique for routine clinical studies. We believe that further basic studies as well as clinical applications of this new technique will define the real significance of oxygen-enhanced MR imaging for the future of pulmonary functional imaging and its usefulness for diagnostic radiology and pulmonary medicine

Basic Skills Assessment

Science.gov (United States)

Yin, Alexander C.; Volkwein, J. Fredericks

2010-01-01

After surveying 1,827 students in their final year at eighty randomly selected two-year and four-year public and private institutions, American Institutes for Research (2006) reported that approximately 30 percent of students in two-year institutions and nearly 20 percent of students in four-year institutions have only basic quantitative…

Basic Properties and Problem Fields of Scientific-Innovation Space of the Region

Directory of Open Access Journals (Sweden)

Alexey Aleksandrovich Rumyantsev

2013-06-01

Full Text Available Increasing scale of the scientific-innovative activity in administrative-territorial units, complicating structure of the regional scientific-innovative complexes and development of inter-regional horizontal and vertical ties expand the space of the scientific and innovation activity research of which primarily involves the development of theoretical and methodological provisions. Basing on the philosophical category «space», the paper describes main properties of the scientific-innovative space of the region and the factors causing them. The author identified problem fields as the direction of possible transformation of scientific-innovative space of the region. The analysis allowed defining some features of the scientific and innovation space and problems of development. The obtained results show the feasibility of study of the scientific-innovative activity in the spatial dimension

The regional seas programme of UNEP

Energy Technology Data Exchange (ETDEWEB)

Bliss-Guest, P.A. (United Nations Environment Programme, Geneva, Switzerland); Keckes, S.

1982-04-01

The 1972 United Nations Conference on the Human Environment (Stockholm) outlined a ''master plan'' for protecting the world's environment which linked environmental assessment, environmental management, and supporting measures, as basic and inseparable elements - also recognizing the advantages of a regional approach in contributing to the solution of global problems. The development of UNEP's Regional Seas Programme, since the Action Plan for the Mediterranean was adopted in 1975, demonstrates that the basic concepts formulated at Stockholm can effectively foster regional cooperation among interested States, and that such cooperation can and does benefit greatly from the support of the United Nations as a whole. The viability of any long-term regional programme lies with the political and financial commitment of the Governments concerned. Within the UNEP Regional Seas Programme this commitment is usually formalized through binding regional legal agreements, and is manifested concretely through an agreed set of activities that are revised periodically by the Governments involved. It is expected that these activities will be adquately supported by financial resources put at the disposal of each of the regional programmes primarily by the Governments concerned.

Level of knowledge among the population of radiation safety basic issues

Directory of Open Access Journals (Sweden)

S. A. Zelencova

2015-01-01

Full Text Available The goal of research was to determine the level of knowledge among the population on issues like sources of ionising radiation, methods of ionising radiation measurement, measures of self-protection in case of threating or actual radioactive pollution in the district, and to study self-estimation by the population of their knowledge of radiation safety issues. Research was carried out using the method of questioning of population groups in three regions close to the places of previous peaceful nuclear explosions (Arkhangelsk, Murmansk and Tyumen regions, and in five Far East regions of the Russian Federation (Kamchatka, Khabarovsk, Primorsky, Magadan and South-Sakhalin regions after radiation accident in Japan at "Fukushima-1" NPP. This research included processing of 243 questionnaires from the regions close to places of previous peaceful nuclear explosions and 216 questionnaires from the Far East regions.The analysis of obtained questioning results enabled to make the following conclusions: the level of knowledge among the population about the basic concepts of radiation safety appeared to be generally low among respondents of all eight territories. Considerable number of respondents in seven groups correctly mentioned the x-ray device as a source of ionising radiation (from 71 to 88 % of answers. In Murmansk region – only 52 % of the answers. Respondents of the same seven groups often correctly answered the question on how to detect ionising radiation (only with devices – from 68 to 98 % in different groups. The smallest number of correct answers to this question (42 % is also noted among respondents from the Murmansk region.Level of knowledge on self-protection measures at threating or actual radioactive pollution of the places of residence appeared a little higher among the Far East region population, who had actual concerns regarding the threat of radioactive pollution at the present time. However, in all eight investigated groups

Basic level category structure emerges gradually across human ventral visual cortex.

Science.gov (United States)

Iordan, Marius Cătălin; Greene, Michelle R; Beck, Diane M; Fei-Fei, Li

2015-07-01

Objects can be simultaneously categorized at multiple levels of specificity ranging from very broad ("natural object") to very distinct ("Mr. Woof"), with a mid-level of generality (basic level: "dog") often providing the most cognitively useful distinction between categories. It is unknown, however, how this hierarchical representation is achieved in the brain. Using multivoxel pattern analyses, we examined how well each taxonomic level (superordinate, basic, and subordinate) of real-world object categories is represented across occipitotemporal cortex. We found that, although in early visual cortex objects are best represented at the subordinate level (an effect mostly driven by low-level feature overlap between objects in the same category), this advantage diminishes compared to the basic level as we move up the visual hierarchy, disappearing in object-selective regions of occipitotemporal cortex. This pattern stems from a combined increase in within-category similarity (category cohesion) and between-category dissimilarity (category distinctiveness) of neural activity patterns at the basic level, relative to both subordinate and superordinate levels, suggesting that successive visual areas may be optimizing basic level representations.

Cloning of human basic A1, a distinct 59-kDa dystrophin-associated protein encoded on chromosome 8q23-24

Energy Technology Data Exchange (ETDEWEB)

Ahn, A.H. [Harvard Medical School, Boston, MA (United States); Yoshida, Mikiharu; Hagiwara, Yasuko; Ozawa, Eijiro [National Institute of Neuroscience, Ogawa Higashi, Kodaira (Japan); Anderson, M.S.; Feener, C.A.; Selig, S. [Howard Hughes Medical Institute at Children`s Hospital, Boston, MA (United States); Kunkel, L.M. [Harvard Medical School, Boston, MA (United States)]|[Howard Hughes Medical Institute at Children`s Hosptial, Boston, MA (United States)

1994-05-10

Duchenne and Becker muscular dystrophies are caused by defects of dystrophin, which forms a part of the membrane cytoskeleton of specialized cells such as muscle. It has been previously shown that the dystrophin-associated protein A1 (59-kDa DAP) is actually a heterogeneous group of phosphorylated proteins consisting of an acidic ({alpha}-A1) and a distinct basic ({beta}-A1) component. Partial peptide sequence of the A1 complex purified from rabbit muscle permitted the design of oligonucleotide probes that were used to isolate a cDNA for one human isoform of A1. This cDNA encodes a basic A1 isoform that is distinct from the recently described syntrophins in Torpedo and mouse and is expressed in many tissues with at least five distinct mRNA species of 5.9, 4.8, 4.3, 3.1, and 1.5 kb. A comparison of the human cDNA sequence with the GenBank expressed sequence tag (EST) data base has identified a relative from human skeletal muscle, EST25263, which is probably a human homologue of the published mouse syntrophin 2. The authors have mapped the human basic component of A1 and EST25263 genes to chromosomes 8q23-24 and 16, respectively.

Basic hydraulics

CERN Document Server

Smith, P D

1982-01-01

BASIC Hydraulics aims to help students both to become proficient in the BASIC programming language by actually using the language in an important field of engineering and to use computing as a means of mastering the subject of hydraulics. The book begins with a summary of the technique of computing in BASIC together with comments and listing of the main commands and statements. Subsequent chapters introduce the fundamental concepts and appropriate governing equations. Topics covered include principles of fluid mechanics; flow in pipes, pipe networks and open channels; hydraulic machinery;

Basic semiconductor physics

CERN Document Server

Hamaguchi, Chihiro

2017-01-01

This book presents a detailed description of basic semiconductor physics. The text covers a wide range of important phenomena in semiconductors, from the simple to the advanced. Four different methods of energy band calculations in the full band region are explained: local empirical pseudopotential, non-local pseudopotential, KP perturbation and tight-binding methods. The effective mass approximation and electron motion in a periodic potential, Boltzmann transport equation and deformation potentials used for analysis of transport properties are discussed. Further, the book examines experiments and theoretical analyses of cyclotron resonance in detail. Optical and transport properties, magneto-transport, two-dimensional electron gas transport (HEMT and MOSFET) and quantum transport are reviewed, while optical transition, electron-phonon interaction and electron mobility are also addressed. Energy and electronic structure of a quantum dot (artificial atom) are explained with the help of Slater determinants. The...

Cone beam computed tomography: basics and applications in dentistry.

Science.gov (United States)

Venkatesh, Elluru; Elluru, Snehal Venkatesh

2017-01-01

The introduction of cone beam computed tomography (CBCT) devices, changed the way oral and maxillofacial radiology is practiced. CBCT was embraced into the dental settings very rapidly due to its compact size, low cost, low ionizing radiation exposure when compared to medical computed tomography. Alike medical CT, 3 dimensional evaluation of the maxillofacial region with minimal distortion is offered by the CBCT. This article provides an overview of basics of CBCT technology and reviews the specific application of CBCT technology to oral and maxillofacial region with few illustrations.

Criticality analyses of regions containing uranium in the earth history

International Nuclear Information System (INIS)

Ravnik, M.

2005-01-01

Investigations of necessary conditions for a self-sustained chain reaction in the Earth inner regions hypothetically containing uranium is presented for the time interval from Earth formation to present time. It is determined that criticality was theoretically possible up to 2.5 Ga before present if uranium concentrated in pure form. In the early geological history (4 Ga before present) the self-sustained criticality could occur even if uranium was diluted up to 1:20 by the average core material or 1:60 by the average mantle material. If other metallic materials of similar density as uranium (e.g., Au, W) or similar atomic weight (e.g., Th) concentrated from the primordial mixture in equal proportion as uranium, criticality was not possible for any period in Earth history provided that the basic material contained no light nuclides (H, C). Criticality in the Earth inner regions could have established only if uranium concentrated from the basic material more effectively than elements of similar density or atomic number. (orig.)

Anesthesia Basics

Science.gov (United States)

... Staying Safe Videos for Educators Search English Español Anesthesia Basics KidsHealth / For Teens / Anesthesia Basics What's in ... español Conceptos básicos sobre la anestesia What Is Anesthesia? No doubt about it, getting an operation can ...

A PBE hybrid functional study of blue-shifting and red-shifting hydrogen bonds in p hydrocarbons

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Boaz Galdino de Oliveira

2009-07-01

Full Text Available This study examines a selected group of p hydrocarbon complexes, represented by C2H4•••HCF3, C2H2•••HCF3, C2H4•••HCF3 and C2H2•••HCF3, from a theoretical point of view. From BPBE/6-311++G(d,p calculations, the geometrical results of these complexes revealed an elongation and shortening of the H—C bond lengths of chloroform (HCCl3 and fluoroform (HCF3, respectively. In terms of the infrared spectrum, the analysis of stretch frequencies revealed that the variations in the H—C modes are essentially recognized as red and blue-shifting modes. For the purposes of understanding the two vibrational phenomena of the p hydrocarbon complexes studied here, PBE/6-311++G(d,p calculations were carried out and partitioning of atomic charges derived from the ChelpG algorithm were also used. A theoretical justification of red- and blue-shift effects was drawn up using charge-transfer analysis, which is manifested in the p bonds of acetylene and ethylene to chloroform (H—CCl3 and fluoroform (H—CF3, respectively. Finally, a further debate regarding the distinct polarizability power of chloroform and fluoroform is presented, concluding that, in comparison with fluoroform, chloroform possesses the requisite features for conventional proton donors and a red-shift is therefore observed in the C2H4•••HCCl3 and C2H2•••HCCl3 complexes.

Function modification of SR-PSOX by point mutations of basic amino acids

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Chen Chunxia

2011-04-01

Full Text Available Abstract Background Atherosclerosis (AS is a common cardiovascular disease. Transformation of macrophages to form foam cells by internalizing modified low density-lipoprotein (LDL via scavenger receptor (SR is a key pathogenic process in the onset of AS. It has been demonstrated that SR-PSOX functions as either a scavenger receptor for uptake of atherogenic lipoproteins and bacteria or a membrane-anchored chemokine for adhesion of macrophages and T-cells to the endothelium. Therefore, SR-PSOX plays an important role in the development of AS. In this study the key basic amino acids in the chemokine domain of SR-PSOX have been identified for its functions. Results A cell model to study the functions of SR-PSOX was successfully established. Based on the cell model, a series of mutants of human SR-PSOX were constructed by replacing the single basic amino acid residue in the non-conservative region of the chemokine domain (arginine 62, arginine 78, histidine 80, arginine 82, histidine 85, lysine 105, lysine 119, histidine 123 with alanine (designated as R62A, R78A, H80A, R82A, H85A, K105A, K119A and H123A, respectively. Functional studies showed that the mutants with H80A, H85A, and K105A significantly increased the activities of oxLDL uptake and bacterial phagocytosis compared with the wild-type SR-PSOX. In addition, we have also found that mutagenesis of either of those amino acids strongly reduced the adhesive activity of SR-PSOX by using a highly non-overlapping set of basic amino acid residues. Conclusion Our study demonstrates that basic amino acid residues in the non-conservative region of the chemokine domain of SR-PSOX are critical for its functions. Mutation of H80, H85, and K105 is responsible for increasing SR-PSOX binding with oxLDL and bacteria. All the basic amino acids in this region are important in the cells adhesion via SR-PSOX. These findings suggest that mutagenesis of the basic amino acids in the chemokine domain of SR-PSOX may

Optimization of paper bridge loading for 2-DE analysis in the basic pH region: application to the mitochondrial subproteome.

Science.gov (United States)

Kane, Lesley A; Yung, Christina K; Agnetti, Giulio; Neverova, Irina; Van Eyk, Jennifer E

2006-11-01

Separation of basic proteins with 2-DE presents technical challenges involving protein precipitation, load limitations, and streaking. Cardiac mitochondria are enriched in basic proteins and difficult to resolve by 2-DE. We investigated two methods, cup and paper bridge, for sample loading of this subproteome into the basic range (pH 6-11) gels. Paper bridge loading consistently produced improved resolution of both analytical and preparative protein loads. A unique benefit of this technique is that proteins retained in the paper bridge after loading basic gels can be reloaded onto lower pH gradients (pH 4-7), allowing valued samples to be analyzed on multiple pH ranges.

An Applied Study on the Decontamination and Decommissioning of Hot Cell Facilities in the United States and Comparison with the Studsvik Facility for Solid and Liquid Waste

International Nuclear Information System (INIS)

Varley, Geoff; Rusch, Chris

2006-07-01

This report presents the plans, processes and results of the decontamination and decommissioning of the Hot Cell Facility in Building 23 at the General Atomics Torrey Pines Mesa Facility (HCF) and compares the program and cost of decommissioning HCF with the Swedish cost estimate for decontamination and decommissioning of the HM hot cell and wastes treatment facility at Studsvik in Sweden. The HCF had three main hot cells and was licensed to: Receive, handle and ship radioactive materials; Remotely handle, examine and store irradiated fuel materials; Extract tritium (engineering scale); Support new reactor production development; Develop, fabricate and inspect UO 2 - BeO fuel materials. The HM facility in Studsvik was constructed to handle and package medium-active solid and liquid wastes, prior to disposal. Central to the facility is a conventional hot cell including three work stations, serviced by master slave manipulators. Other parts of the facility include holding tanks for liquid wastes and slurries, a centrifuge room, as well as an encapsulation station where drummed wastes can be encapsulated in cement, offices, laboratories and workshops and so on, as well as building and cell ventilation systems. Decontamination and decommissioning of the HCF took place during 1993 through 2001. The objective was to obtain regulatory release of the site so that it could be used on an unrestricted basis. Based on data from extensive hazardous and radiological materials characterization, GA evaluated four decommissioning options and selected dismantling as the only option that would satisfy the decommissioning objective. The decontamination and decommissioning scope included the following actions. 1. Remove the legacy waste that consisted of radioactive wastes stored at the HCF consisting of 21,434 kg of irradiated fuel material (IFM) that was owned by the US DoE and store the waste in temporary storage set up at the GA site. 2. Actual Decontamination and Dismantlement

An Applied Study on the Decontamination and Decommissioning of Hot Cell Facilities in the United States and Comparison with the Studsvik Facility for Solid and Liquid Waste

Energy Technology Data Exchange (ETDEWEB)

Varley, Geoff; Rusch, Chris [NAC International, Atlanta, GA (United States)

2006-07-15

This report presents the plans, processes and results of the decontamination and decommissioning of the Hot Cell Facility in Building 23 at the General Atomics Torrey Pines Mesa Facility (HCF) and compares the program and cost of decommissioning HCF with the Swedish cost estimate for decontamination and decommissioning of the HM hot cell and wastes treatment facility at Studsvik in Sweden. The HCF had three main hot cells and was licensed to: Receive, handle and ship radioactive materials; Remotely handle, examine and store irradiated fuel materials; Extract tritium (engineering scale); Support new reactor production development; Develop, fabricate and inspect UO{sub 2} - BeO fuel materials. The HM facility in Studsvik was constructed to handle and package medium-active solid and liquid wastes, prior to disposal. Central to the facility is a conventional hot cell including three work stations, serviced by master slave manipulators. Other parts of the facility include holding tanks for liquid wastes and slurries, a centrifuge room, as well as an encapsulation station where drummed wastes can be encapsulated in cement, offices, laboratories and workshops and so on, as well as building and cell ventilation systems. Decontamination and decommissioning of the HCF took place during 1993 through 2001. The objective was to obtain regulatory release of the site so that it could be used on an unrestricted basis. Based on data from extensive hazardous and radiological materials characterization, GA evaluated four decommissioning options and selected dismantling as the only option that would satisfy the decommissioning objective. The decontamination and decommissioning scope included the following actions. 1. Remove the legacy waste that consisted of radioactive wastes stored at the HCF consisting of 21,434 kg of irradiated fuel material (IFM) that was owned by the US DoE and store the waste in temporary storage set up at the GA site. 2. Actual Decontamination and

Basic math and pre-algebra practice problems for dummies

CERN Document Server

Zegarelli, Mark

2013-01-01

1001 Basic Math & Pre- Algebra Practice Problems For  Dummies   Practice makes perfect-and helps deepen your understanding of basic math and pre-algebra 1001 Basic Math & Pre-Algebra Practice Problems For Dummies, with free access to online practice problems, takes you beyond the instruction and guidance offered in Basic Math & Pre-Algebra For Dummies, giving you 1,001 opportunities to practice solving problems from the major topics in your math course. You begin with some basic arithmetic practice, move on to fractions, decimals, and per

Stereochemistry basic concepts and applications

CERN Document Server

Nógrádi, M

2013-01-01

Stereochemistry: Basic Concepts and Applications is a three-chapter text that introduces the basic principles and concepts of stereochemistry, as well as its application to organic chemistry application.Chapter 1 describes first the stereochemistry of the ground state, specifically the configuration and conformation of organic compounds, as well as the most important methods for its investigation. This chapter also deals with the kinetics of conformational changes and provides an overview of the so-called ""applied stereochemistry"". Chapter 2 focuses on the analysis of the internal motions of

Recombination in the human Pseudoautosomal region PAR1.

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Anjali G Hinch

2014-07-01

Full Text Available The pseudoautosomal region (PAR is a short region of homology between the mammalian X and Y chromosomes, which has undergone rapid evolution. A crossover in the PAR is essential for the proper disjunction of X and Y chromosomes in male meiosis, and PAR deletion results in male sterility. This leads the human PAR with the obligatory crossover, PAR1, to having an exceptionally high male crossover rate, which is 17-fold higher than the genome-wide average. However, the mechanism by which this obligatory crossover occurs remains unknown, as does the fine-scale positioning of crossovers across this region. Recent research in mice has suggested that crossovers in PAR may be mediated independently of the protein PRDM9, which localises virtually all crossovers in the autosomes. To investigate recombination in this region, we construct the most fine-scale genetic map containing directly observed crossovers to date using African-American pedigrees. We leverage recombination rates inferred from the breakdown of linkage disequilibrium in human populations and investigate the signatures of DNA evolution due to recombination. Further, we identify direct PRDM9 binding sites using ChIP-seq in human cells. Using these independent lines of evidence, we show that, in contrast with mouse, PRDM9 does localise peaks of recombination in the human PAR1. We find that recombination is a far more rapid and intense driver of sequence evolution in PAR1 than it is on the autosomes. We also show that PAR1 hotspot activities differ significantly among human populations. Finally, we find evidence that PAR1 hotspot positions have changed between human and chimpanzee, with no evidence of sharing among the hottest hotspots. We anticipate that the genetic maps built and validated in this work will aid research on this vital and fascinating region of the genome.

Cultured human foreskin fibroblasts produce a factor that stimulates their growth with properties similar to basic fibroblast growth factor

International Nuclear Information System (INIS)

Story, M.T.

1989-01-01

To determine if fibroblasts could be a source of fibroblast growth factor (FGF) in tissue, cells were initiated in culture from newborn human foreskin. Fibroblast cell lysates promoted radiolabeled thymidine uptake by cultured quiescent fibroblasts. Seventy-nine percent of the growth-promoting activity of lysates was recovered from heparin-Sepharose. The heparin-binding growth factor reacted on immunoblots with antiserum to human placenta-derived basic FGF and competed with iodinated basic FGF for binding to antiserum to (1-24)bFGF synthetic peptide. To confirm that fibroblasts were the source of the growth factor, cell lysates were prepared from cells incubated with radiolabeled methionine. Heparin affinity purified material was immunoprecipitated with basic FGF antiserum and electrophoresed. Radiolabeled material was detected on gel autoradiographs in the same molecular weight region as authentic iodinated basic FGF. The findings are consistant with the notion that cultured fibroblasts express basic FGF. As these cells also respond to the mitogen, it is possible that the regulation of their growth is under autocrine control. Fibroblasts may be an important source of the growth factor in tissue

A single-walled carbon nanotubes/poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate)/copper hexacyanoferrate hybrid film for high-volumetric performance flexible supercapacitors

Science.gov (United States)

Li, Jianmin; Li, Haizeng; Li, Jiahui; Wu, Guiqing; Shao, Yuanlong; Li, Yaogang; Zhang, Qinghong; Wang, Hongzhi

2018-05-01

Volumetric energy density is generally considered to be detrimental to the actual application of supercapacitors, which has provoked a range of research work on increasing the packing density of electrodes. Herein, we fabricate a free-standing single-walled carbon nanotubes (SWCNTs)/poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS)/copper hexacyanoferrate (CuHCF) nanoparticles (NPs) composite supercapacitor electrode, with a high packing density of 2.67 g cm-3. The pseudocapacitive CuHCF NPs are decorated onto the SWCNTs/PEDOT:PSS networks and filled in interspace to increase both of packing density and specific capacitance. This hybrid electrode exhibits a series of outstanding performances, such as high electric conductivity, ultrahigh areal and volumetric capacitances (969.8 mF cm-2 and 775.2 F cm-3 at scan rate of 5 mV s-1), long cycle life and superior rate capability. The asymmetric supercapacitor built by using the SWCNTs/PEDOT:PSS/CuHCF film as positive electrode and Mo-doped WO3/SWCNTs film as negative electrode, can deliver a high energy density of 30.08 Wh L-1 with a power density of 4.25 kW L-1 based on the total volume of the device. The approach unveiled in this study could provide important insights to improving the volumetric performance of energy storage devices and help to reach the critical targets for high rate and high power density demand applications.

F-Element ion chelation in highly basic media. Annual progress report, October 1, 1996 - July 1, 1997

International Nuclear Information System (INIS)

Paine, R.T.

1997-01-01

'The specific fundamental chemical objectives of this project are to: (1) study the chemical speciation of Sr and Ln ions in basic media formed in aqueous solutions with and without classical chelation agents (e.g., EDTA, polyphosphates, and organic carboxylates); (2) prepare pyridine N-oxide phosphonate and phosphonoacetate chelators of the types 1--3 and characterize their ionization properties by titrimetric techniques; (3) study the interactions of 5--7 with soluble oxide-hydroxide metallate species and higher molecular weight sols, gels and precipitates containing Sr and Ln ions, as time permits, interactions with oxide-hydroxide metallates of U, Th, Ba, Al and Fe will also be studied; (4) study the interactions of newly designed phosphonate ligands with oxide-hydroxide metallate species; (5) transfer the fundamental coordination chemistry revealed here to research groups at LANL and PNNL that will utilize the results to improve tank waste treatment protocols.'

BASIC Programming.

Science.gov (United States)

Jennings, Carol Ann

Designed for use by both secondary- and postsecondary-level business teachers, this curriculum guide consists of 10 units of instructional materials dealing with Beginners All-Purpose Symbol Instruction Code (BASIC) programing. Topics of the individual lessons are numbering BASIC programs and using the PRINT, END, and REM statements; system…

EPA Region 1 No Discharge Zones

Science.gov (United States)

This dataset details No Discharge Zones (NDZ) for New England. Boaters may not discharge waste into these areas. Boundaries were determined mostly by Federal Register Environmental Documents in coordination with Massachusetts Coastal Zone Management (MA CZM) and EPA Region 1 Office of Ecosystem Protection (OEP) staff.

IMPROVING MANAGEMENT QUALITY BASED ON A REGIONAL INNOVATION DEVELOPMENT BY THE EXAMPLE OF THE SAMARA REGION: ESTIMATE INDICATORS

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Robert R. Bakhtiev

2013-01-01

Full Text Available The article considers the basic ways of improving management quality via a regional innovation development based on the correlation analysis. The necessity of formation of qualitative information interaction of parts of a regional innovation system is proved. It allows creating more effective innovation process in the region.

Copyright Law Basics for the Nursing Professional: Part 1: Using the Work of Others.

Science.gov (United States)

LaVelle, Meghan B; LaVelle, Beth Elchek; Port, Kenneth L; Sherlock, Jacob T

2015-01-01

This article covers the basics of Copyright Law as applicable to the use of protected resources and the sharing of information by nurse professionals. It explores frequently cited justifications for copyright violation, including the doctrine of Fair Use and the Technology and Copyright Harmonization Act. It also discusses why those justifications may or may not apply to the nurse professional who teaches in a clinical setting or at a conference.(See CE Video, Supplemental Digital Content 1, http://links.lww.com/JNPD/A2).

The United Nations Basic Space Science Initiative

Science.gov (United States)

Haubold, Hans; Balogh, Werner

2014-05-01

The basic space science initiative was a long-term effort for the development of astronomy and space science through regional and international cooperation in this field on a worldwide basis, particularly in developing nations. Basic space science workshops were co-sponsored and co-organized by ESA, JAXA, and NASA. A series of workshops on basic space science was held from 1991 to 2004 (India 1991, Costa Rica and Colombia 1992, Nigeria 1993, Egypt 1994, Sri Lanka 1995, Germany 1996, Honduras 1997, Jordan 1999, France 2000, Mauritius 2001, Argentina 2002, and China 2004; http://neutrino.aquaphoenix.com/un-esa/) and addressed the status of astronomy in Asia and the Pacific, Latin America and the Caribbean, Africa, and Western Asia. Through the lead of the National Astronomical Observatory Japan, astronomical telescope facilities were inaugurated in seven developing nations and planetariums were established in twenty developing nations based on the donation of respective equipment by Japan.Pursuant to resolutions of the Committee on the Peaceful Uses of Outer Space of the United Nations (COPUOS) and its Scientific and Technical Subcommittee, since 2005, these workshops focused on the preparations for and the follow-ups to the International Heliophysical Year 2007 (UAE 2005, India 2006, Japan 2007, Bulgaria 2008, South Korea 2009; www.unoosa.org/oosa/SAP/bss/ihy2007/index.html). IHY's legacy is the current operation of 16 worldwide instrument arrays with more than 1000 instruments recording data on solar-terrestrial interaction from coronal mass ejections to variations of the total electron content in the ionosphere (http://iswisecretariat.org/). Instruments are provided to hosting institutions by entities of Armenia, Brazil, France, Israel, Japan, Switzerland, and the United States. Starting in 2010, the workshops focused on the International Space Weather Initiative (ISWI) as mandated in a three-year-work plan as part of the deliberations of COPUOS. Workshops on ISWI

Numerical modeling of the groundwater contaminant transport for the Lake Karachai Area: The methodological approach and the basic two- dimensional regional model

International Nuclear Information System (INIS)

Petrov, A.V.; Samsonova, L.M.; Vasil'kova, N.A.; Zinin, A.I.; Zinina, G.A.

1994-06-01

Methodological aspects of the numerical modeling of the groundwater contaminant transport for the Lake Karachay area are discussed. Main features of conditions of the task are the high grade of non-uniformity of the aquifer in the fractured rock massif and the high density of the waste solutions, and also the high volume of the input data: both on the part of parameters of the aquifer (number of pump tests) and on the part of observations of functions of processes (long-time observations by the monitoring well grid). The modeling process for constructing the two dimensional regional model is described, and this model is presented as the basic model for subsequent full three-dimensional modeling in sub-areas of interest. Original powerful mathematical apparatus and computer codes for finite-difference numerical modeling are used

Management of Refractive Errors And Low Vision Among Basic ...

African Journals Online (AJOL)

The study sought to discuss the management of refractive errors and low vision among basic school children in the Atwima district. A sample of 1,177 public basic school children aged between 5-19 years was randomly selected from ten basic schools for examination. Thirteen key informants in the district were purposively ...

China Dimensions Data Collection: China Administrative Regions GIS Data: 1:1M, County Level, 1990

Data.gov (United States)

National Aeronautics and Space Administration — China Administrative Regions GIS Data: 1:1M, County Level, 1990 consists of geographic boundary data for the administrative regions of China as of 31 December 1990....

Understanding water deficit stress-induced changes in the basic metabolism of higher plants - biotechnologically and sustainably improving agriculture and the ecoenvironment in arid regions of the globe.

Science.gov (United States)

Shao, Hong-Bo; Chu, Li-Ye; Jaleel, C Abdul; Manivannan, P; Panneerselvam, R; Shao, Ming-An

2009-01-01

Water is vital for plant growth, development and productivity. Permanent or temporary water deficit stress limits the growth and distribution of natural and artificial vegetation and the performance of cultivated plants (crops) more than any other environmental factor. Productive and sustainable agriculture necessitates growing plants (crops) in arid and semiarid regions with less input of precious resources such as fresh water. For a better understanding and rapid improvement of soil-water stress tolerance in these regions, especially in the water-wind eroded crossing region, it is very important to link physiological and biochemical studies to molecular work in genetically tractable model plants and important native plants, and further extending them to practical ecological restoration and efficient crop production. Although basic studies and practices aimed at improving soil water stress resistance and plant water use efficiency have been carried out for many years, the mechanisms involved at different scales are still not clear. Further understanding and manipulating soil-plant water relationships and soil-water stress tolerance at the scales of ecology, physiology and molecular biology can significantly improve plant productivity and environmental quality. Currently, post-genomics and metabolomics are very important in exploring anti-drought gene resources in various life forms, but modern agriculturally sustainable development must be combined with plant physiological measures in the field, on the basis of which post-genomics and metabolomics have further practical prospects. In this review, we discuss physiological and molecular insights and effects in basic plant metabolism, drought tolerance strategies under drought conditions in higher plants for sustainable agriculture and ecoenvironments in arid and semiarid areas of the world. We conclude that biological measures are the bases for the solutions to the issues relating to the different types of

Myostatin inhibitory region of fish (Paralichthys olivaceus) myostatin-1 propeptide.

Science.gov (United States)

Lee, Sang Beum; Kim, Jeong Hwan; Jin, Deuk-Hee; Jin, Hyung-Joo; Kim, Yong Soo

2016-01-01

Myostatin (MSTN) is a potent negative regulator of skeletal muscle growth, and its activity is suppressed by MSTN propeptide (MSTNpro), the N-terminal part of MSTN precursor cleaved during post-translational MSTN processing. The current study examined which region of flatfish (Paralichthys olivaceus) MSTN-1 propeptide (MSTN1pro) is critical for MSTN inhibition. Six different truncated forms of MSTN1pro containing N-terminal maltose binding protein (MBP) as a fusion partner were expressed in Escherichia coli, and partially purified by an affinity chromatography for MSTN-inhibitory activity examination. Peptides covering different regions of flatfish MSTN1pro were also synthesized for MSTN-inhibitory activity examination. A MBP-fused MSTN1pro region consisting of residues 45-100 had the same MSTN-inhibitory potency as the full sequence flatfish MSTN1pro (residues 23-265), indicating that the region of flatfish MSTN1pro consisting of residues 45-100 is sufficient to maintain the full MSTN-inhibitory capacity. A MBP-fused MSTN1pro region consisting of residues 45-80 (Pro45-80) also showed MSTN-inhibitory activity with a lower potency, and the Pro45-80 demonstrated its MSTN binding capacity in a pull-down assay, indicating that the MSTN-inhibitory capacity of Pro45-80 is due to its binding to MSTN. Flatfish MSTN1pro synthetic peptides covering residues 45-65, 45-70, and 45-80 demonstrated MSTN-inhibitory activities, but not the synthetic peptide covering residues 45-54, indicating that residues 45-65 of flatfish MSTN1pro are essential for MSTN inhibition. In conclusion, current study show that like the mammalian MSTNpro, the MSTN-inhibitory region of flatfish MSTN1pro resides near its N-terminus, and imply that smaller sizes of MSTNpro can be effectively used in various applications designed for MSTN inhibition. Copyright © 2016 Elsevier Inc. All rights reserved.

Effectiveness of transposed inverse sets in faber regions

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J. A. Adepoju

1983-01-01

of a given basic set of polynominals, are investigated in the present paper. A certain inevitable normalizing substitution, is first formulated, to be undergone by the given set to ensure the existence of the transposed inverse in the Faber region. The first main result of the present work (Theorem 2.1, on the one hand, provides a lower bound of the class of functions for which the normalized transposed inverse set is effective in the Faber region. On the other hand, the second main result (Theorem 5.2 asserts the fact that the normalized transposed inverse set of a simple set of polynomials, which is effective in a Faber region, should not necessarily be effective there.

Antioxidant effect of sericin in brain and peripheral tissues of oxidative stress induced hypercholesterolemic rats

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Meetali Deori

2016-09-01

Full Text Available This study evaluated the antioxidant effect of crude sericin extract (CSE from Antheraea assamenisis (Aa in high cholesterol fed rats. Investigation was conducted by administering graded oral dose of 0.25 and 0.5 gm/kg body weight (b.w./day of CSE for a period of 28 days. Experiments were conducted in 30 rats and were divided into five groups: normal control (NC, high cholesterol fed (HCF, HCF + 0.065 gm/kg b.w./day fenofibrate (FF, HCF + sericin 0.25 gm/kg b.w./day (LSD and HCF + sericin 0.5 gm/kg b.w./day (HSD. In brain, heart, liver, serum and kidney homogenates nitric oxide (NO, thiobarbituric acid reactive substances (TBARS, protein carbonyl content (PCC, superoxide dismutase (SOD, reduced glutathione (GSH was measured. LSD treatment prevented the alterations in GSH and PCC levels in hypercholesterolemic (HyC brain tissue homogenates of rats. CSE lowers the serum total cholesterol level in HyC rats by promoting fecal cholesterol (FC excretion. CSE increases FC level by promoting inhibition of cholesterol absorption in intestine. The endogenous antioxidant reduced significantly and the oxidative stress (OS marker TBARS level increases significantly in the peripheral tissue of HCF rats. However, the administration of LSD and HSD exhibited a good antioxidant activity by reducing the TBARS level and increasing the endogenous antioxidant in peripheral tissue. In addition, a histological examination revealed loss of normal liver and kidney architecture in cholesterol fed rats which were retained in sericin treated groups. The findings of this study suggested that CSE improves hypercholesterolemia in rats fed a HyC diet. Clinical relevance of this effect of CSE seems worthy of further studies.

Hydromechanics - basic properties

International Nuclear Information System (INIS)

Lee, Sung Tak; Lee, Je Geun

1987-03-01

This book tells of hydromechanics, which is about basic properties of hydromechanics such as conception, definition, mass, power and weight, and perfect fluid and perfect gas, hydrostatics with summary, basic equation of hydrostatics, relative balance of hydrostatics, and kinematics of hydromechanics, description method of floating, hydromechanics about basic knowledge, equation of moment, energy equation and application of Bernoulli equation, application of momentum theory, inviscid flow and fluid measuring.

Hot Cell Facility modifications at Sandia National Laboratories to support 99Mo production

International Nuclear Information System (INIS)

Vernon, M.; Philbin, J.; Berry, D.

1997-01-01

In September, 1996, following the completion of an extensive Environmental Impact Statement (EIS), a record of decision (ROD) was issued by DOE selecting Sandia as the facility to take on the 99 Mo production mission. 99 Mo is the precursor to 99m Tc which is used in 36,000 medical procedures per day in the US. to meet US 99 Mo medical demands, 20 kCi of 99 Mo must be delivered to the pharmaceutical companies each week. This could be accomplished by the processing of twenty-five targets (total fission product of 15 kCi/target) each week within the SNL Hot Cell Facility (HCF). To accomplish this new mission, significant modifications to the HCF will have to be undertaken. This paper presents a brief history of the HCF, and describes modifications necessary to achieve DOE directives

EPA Region 1 Coast Guard Jurisdictional Boundary - Polygons

Data.gov (United States)

U.S. Environmental Protection Agency — Jurisdictional boundary between EPA and Coast Guard for EPA Region I. Created from 1:100000 USGS DLGs with greater detail drawn from 1:24000 commercial street data...

EPA Region 1 Coast Guard Jurisdictional Boundary - Arcs

Data.gov (United States)

U.S. Environmental Protection Agency — Jurisdictional boundary between EPA and Coast Guard for EPA Region I. Created from 1:100000 USGS DLGs with greater detail drawn from 1:24000 commercial street data...

Epidemiological characteristics of the influenza A(H1N1 2009 pandemic in the Western Pacific Region

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Lisa McCallum

2010-12-01

Full Text Available The first laboratory-confirmed cases of infection with pandemic influenza A(H1N1 2009 in the Western Pacific Region were reported on 28 April 2009. By 11 June 2009, the day the pandemic was declared by the World Health Organization, nine Western Pacific Region countries and areas had reported laboratory-confirmed pandemic influenza A(H1N1 2009 cases. From April 2009 to July 2010, more than 250 000 cases and 1800 deaths from laboratory-confirmed pandemic influenza A(H1N1 2009 were reported from 34 countries and areas in the Region. By age group region-wide, 8.6%, 41.9%, 48.3%, and 1.2% of cases were in the < 5 years, 5–14 years, 15–64 years, and 65+ years age groups, respectively; the overall crude case fatality ratio in the Western Pacific Region was 0.5%. The pandemic demonstrated that region-wide disease reporting was possible. Countries and areas of the Western Pacific Region should take this opportunity to strengthen the systems established during the pandemic to develop routine disease reporting.

Basic molecular spectroscopy

CERN Document Server

Gorry, PA

1985-01-01

BASIC Molecular Spectroscopy discusses the utilization of the Beginner's All-purpose Symbolic Instruction Code (BASIC) programming language in molecular spectroscopy. The book is comprised of five chapters that provide an introduction to molecular spectroscopy through programs written in BASIC. The coverage of the text includes rotational spectra, vibrational spectra, and Raman and electronic spectra. The book will be of great use to students who are currently taking a course in molecular spectroscopy.

Technical papers 1: regional energy accounting; Cahiers techniques 1: bilan energetique regional

Energy Technology Data Exchange (ETDEWEB)

NONE

2002-07-01

The regional energy accounting is an appropriate tool to the elaboration energy conservation programs. It allows to identify the regional stakes and understand the impacts of the energy policies. In this accounting the consumptions are presented by energy products (petroleum products, mineral solid fuels, renewable energies, electric power, natural gas) and by consumption sectors (steel metallurgy, accommodation, ternary industry, agricultural, transport). (A.L.B.)

CATHEDRAL BASIC EDUCATIONAL INSTITUTIONS AS A BASIS FOR FORMING TECHNOLOGY TEACHER COMPETENCE

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В. М. Жураковская

2014-04-01

Full Text Available The article offers a review of the activities of the cathedral basic educational institutions (KBOU - Lyceum Istra, Moscow region, which implements one of the scientific and methodological areas of activity - the introduction of new educational technologies and principles of the organization of the educational process to ensure effective implementation of key provisions of the federal state educational standards basic general education. The paper proposed a structure of didactic games and one of its examples, focused on becoming a high school student individuality.Purchase on Elibrary.ru > Buy now

Introduction to Probability, Part 1 - Basic Concepts. Student Text. Revised Edition.

Science.gov (United States)

Blakeslee, David W.; And Others

This book is designed to introduce the reader to some fundamental ideas about probability. The mathematical theory of probability plays an increasingly important role in science, government, industry, business, and economics. An understanding of the basic concepts of probability is essential for the study of statistical methods that are widely…

Conservation of Repeats at the Mammalian KCNQ1OT1-CDKN1C Region Suggests a Role in Genomic Imprinting

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Marcos De Donato

2017-06-01

Full Text Available KCNQ1OT1 is located in the region with the highest number of genes showing genomic imprinting, but the mechanisms controlling the genes under its influence have not been fully elucidated. Therefore, we conducted a comparative analysis of the KCNQ1/KCNQ1OT1-CDKN1C region to study its conservation across the best assembled eutherian mammalian genomes sequenced to date and analyzed potential elements that may be implicated in the control of genomic imprinting in this region. The genomic features in these regions from human, mouse, cattle, and dog show a higher number of genes and CpG islands (detected using cpgplot from EMBOSS, but lower number of repetitive elements (including short interspersed nuclear elements and long interspersed nuclear elements, compared with their whole chromosomes (detected by RepeatMasker. The KCNQ1OT1-CDKN1C region contains the highest number of conserved noncoding sequences (CNS among mammals, where we found 16 regions containing about 38 different highly conserved repetitive elements (using mVista, such as LINE1 elements: L1M4, L1MB7, HAL1, L1M4a, L1Med, and an LTR element: MLT1H. From these elements, we found 74 CNS showing high sequence identity (>70% between human, cattle, and mouse, from which we identified 13 motifs (using Multiple Em for Motif Elicitation/Motif Alignment and Search Tool with a significant probability of occurrence, 3 of which were the most frequent and were used to find transcription factor–binding sites. We detected several transcription factors (using JASPAR suite from the families SOX, FOX, and GATA. A phylogenetic analysis of these CNS from human, marmoset, mouse, rat, cattle, dog, horse, and elephant shows branches with high levels of support and very similar phylogenetic relationships among these groups, confirming previous reports. Our results suggest that functional DNA elements identified by comparative genomics in a region densely populated with imprinted mammalian genes may be

SPECIALIZED MAPPING OF CRUSTAL FAULT ZONES. PART 1: BASIC THEORETICAL CONCEPTS AND PRINCIPLES

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K. Zh. Seminsky

2014-01-01

Full Text Available Long-term studies of shear zones have included collection of data on fractures showing no indication of displacement which are termed as 'blank' fractures. A method aimed at mapping fault structures and stress fields has been developed on the basis of results of paragenetic analysis of measurements of abundant fractures. The method is termed as 'specialized mapping', firstly, due to its specific structural goal so that to distinguish it from the conventional geological mapping of regions in nature, and, secondly, because of the specific procedure applied to refer to fractures as references to decipher fault-block patterns of natural regions. In Part 1, basic theoretical concepts and principles of specialized mapping are described. Part 2 is being prepared for publication in one of the next issues of the journal; it will cover stages of the proposed method and describe some of the cases of its application.In terms of general organizational principles, specialized mapping is similar to other methods based on structural paragenetic analysis and differs from such methods in types of paragenesises viewed as references to reveal crustal fault zones. Such paragenesises result from stage-by-stage faulting (Fig 2 and Fig. 7 during which stress fields of the 2nd order are regularly changeable within the shear zone. According to combined experimental and natural data, a complete paragenesis of fractures in the shear zone includes a major (1st order fault plane and fractures of other seven types, R, R’, n, n’, t, t’ and T (2nd order (Fig. 4 and Fig 8. At the fracture level, each of them corresponds to a paragenesis including three nearly perpendicular systems of early ruptures (Fig. 1, which are based on two classical patterns of conjugated fractures, one of which is consistent with the position of the fault plane (Fig. 3. Taking into account that strike-slip, reverse and normal faults are similar in terms of mechanics (i.e. they are formed due to

High-Rate and Long-Term Cycle Stability of Li-S Batteries Enabled by Li2S/TiO2-Impregnated Hollow Carbon Nanofiber Cathodes.

Science.gov (United States)

Wang, Xinran; Bi, Xuanxuan; Wang, Shaona; Zhang, Yi; Du, Hao; Lu, Jun

2018-05-16

The high theoretical energy density of lithium-sulfur (Li-S) batteries makes them an alternative battery technology to lithium ion batteries. However, Li-S batteries suffer from low sulfur loading, poor charge transport, and dissolution of lithium polysulfide. In our study, we use the lithiated S, Li 2 S, as the cathode material, coupled with electrospun TiO 2 -impregnated hollow carbon nanofibers (TiO 2 -HCFs), which serve as the conductive agent and protective barrier for Li 2 S in Li-S batteries. TiO 2 -HCFs provide much improved electron/ionic conductivity and serve as a physical barrier, which prevents the dissolution of lithium polysulfides. The Li 2 S/TiO 2 -HCF composite delivers a discharge capacity of 851 mA h g Li 2 S -1 at 0.1C and the bilayer TiO 2 -HCFs/Li 2 S/TiO 2 -HCF composite delivers a high specific capacity of 400 mA h g Li 2 S -1 at 5C.

5 CFR 534.603 - Rates of basic pay.

Science.gov (United States)

2010-01-01

... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Rates of basic pay. 534.603 Section 534.603 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PAY UNDER OTHER SYSTEMS Pay for Administrative Appeals Judge Positions § 534.603 Rates of basic pay. (a) The...

Forecasting global developments in the basic chemical industry for environmental policy analysis

NARCIS (Netherlands)

Broeren, M.L.M.|info:eu-repo/dai/nl/371687438; Saygin, D.; Patel, M.K.

The chemical sector is the largest industrial energy user, but detailed analysis of its energy use developments lags behind other energy-intensive sectors. A cost-driven forecasting model for basic chemicals production is developed, accounting for regional production costs, demand growth and stock

Basic Education in Tanzania: A Slight Touch on the Views of ...

African Journals Online (AJOL)

The objective of this paper is to visualize what basic education is. To provide a focus to the paper, from 1997-2003, 198 primary seven leavers from Nachingwea and Tandahimba districts in the southern regions of Tanzania were sampled. Six simple questions from six conventional primary school subjects (Kiswahili, ...

Interaction between the C-terminal region of human myelin basic protein and calmodulin: analysis of complex formation and solution structure

Directory of Open Access Journals (Sweden)

Hayashi Nobuhiro

2008-02-01

Full Text Available Abstract Background The myelin sheath is a multilamellar membrane structure wrapped around the axon, enabling the saltatory conduction of nerve impulses in vertebrates. Myelin basic protein, one of the most abundant myelin-specific proteins, is an intrinsically disordered protein that has been shown to bind calmodulin. In this study, we focus on a 19-mer synthetic peptide from the predicted calmodulin-binding segment near the C-terminus of human myelin basic protein. Results The interaction of native human myelin basic protein with calmodulin was confirmed by affinity chromatography. The binding of the myelin basic protein peptide to calmodulin was tested with isothermal titration calorimetry (ITC in different temperatures, and Kd was observed to be in the low μM range, as previously observed for full-length myelin basic protein. Surface plasmon resonance showed that the peptide bound to calmodulin, and binding was accompanied by a conformational change; furthermore, gel filtration chromatography indicated a decrease in the hydrodynamic radius of calmodulin in the presence of the peptide. NMR spectroscopy was used to map the binding area to reside mainly within the hydrophobic pocket of the C-terminal lobe of calmodulin. The solution structure obtained by small-angle X-ray scattering indicates binding of the myelin basic protein peptide into the interlobal groove of calmodulin, while calmodulin remains in an extended conformation. Conclusion Taken together, our results give a detailed structural insight into the interaction of calmodulin with a C-terminal segment of a major myelin protein, the myelin basic protein. The used 19-mer peptide interacts mainly with the C-terminal lobe of calmodulin, and a conformational change accompanies binding, suggesting a novel mode of calmodulin-target protein interaction. Calmodulin does not collapse and wrap around the peptide tightly; instead, it remains in an extended conformation in the solution structure

Basics and application of PSpice

International Nuclear Information System (INIS)

Choi, Pyeong; Cho, Yong Beom; Mok, Hyeong Su; Baek, Dong CHeol

2006-03-01

This book is comprised of nineteenth chapters, which introduces basics and application of PSpice. The contents of this book are PSpice?, PSpice introduction, PSpice simulation, DC analysis, parametric analysis, Transient analysis, parametric analysis and measurements, Monte Carlo analysis, changing of device characteristic, ABM application. The elementary laws of circuit, R.L.C. basic circuit, Diode basic cc circuit, Transistor and EET basic circuit, OP-Amp basic circuit, Digital basic circuit, Analog, digital circuit practice, digital circuit application and practice and ABM circuit application and practice.

13 CFR 304.1 - Designation of Economic Development Districts: Regional eligibility.

Science.gov (United States)

2010-01-01

... Development Districts: Regional eligibility. 304.1 Section 304.1 Business Credit and Assistance ECONOMIC DEVELOPMENT ADMINISTRATION, DEPARTMENT OF COMMERCE ECONOMIC DEVELOPMENT DISTRICTS § 304.1 Designation of Economic Development Districts: Regional eligibility. Upon the request of a District Organization (as...

Column study on electrochemical separation of cesium ions from wastewater using copper hexacyanoferrate film

International Nuclear Information System (INIS)

Chen, Rongzhi; Tanaka, Hisashi; Asai, Miyuki; Fukushima, Chikako; Kawamoto, Tohru; Kurihara, Masato; Ishizaki, Manabu; Arisaka, Makoto; Nankawa, Takuya; Watanabe, Masayuki

2013-01-01

We coated the copper hexacyanoferrate (CuHCF) on the gold electrodes, and then performed the Cs removal by electrochemical separation (ES). The prepared CuHCF nanoparticles can be simply and uniformly coated on electrodes by wet process like conventional printing methods, so any sizes or patterns are feasible at low cost, which indicated the potential as a promising sorption electrode of large size in the columns for sequential removal and recycle of Cs from wastewater. (author)

Medical emergencies in the dental surgery. Part 1: Preparation of the office and basic management.

Science.gov (United States)

Malamed, Stanley F

2015-12-01

Medical emergencies can and do happen in the dental surgery. In the 20- to 30-year practice lifetime of the typical dentist, he/she will encounter between five and seven emergency situations. Being prepared in advance of the emergency increases the likelihood of a successful outcome. PURPOSE OF THE PAPER: To prepare members of the dental office staff to be able to promptly recognize and efficiently manage those medical emergency situations that can occur in the dental office environment. Preparation of the dental office to promptly recognize and efficiently manage medical emergencies is predicated on successful implementation of the following four steps: basic life support for ALL members of the dental office staff; creation of a dental office emergency team; activation of emergency medial services (EMS) when indicated; and basic emergency drugs and equipment. The basic emergency algorithm (P->C->A->B->D) is designed for implementation in all emergency situations. Prompt implementation of the basic emergency management protocol can significantly increase the likelihood of a successful result when medical emergencies occur in the dental office environment.

A clinical prediction rule for histological chorioamnionitis in preterm newborns.

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Jasper V Been

Full Text Available BACKGROUND: Histological chorioamnionitis (HC is an intrauterine inflammatory process highly associated with preterm birth and adverse neonatal outcome. HC is often clinically silent and diagnosed postnatally by placental histology. Earlier identification could facilitate treatment individualisation to improve outcome in preterm newborns. AIM: Develop a clinical prediction rule at birth for HC and HC with fetal involvement (HCF in preterm newborns. METHODS: Clinical data and placental pathology were obtained from singleton preterm newborns (gestational age ≤ 32.0 weeks born at Erasmus UMC Rotterdam from 2001 to 2003 (derivation cohort; n = 216 or Máxima MC Veldhoven from 2009 to 2010 (validation cohort; n = 206. HC and HCF prediction rules were developed with preference for high sensitivity using clinical variables available at birth. RESULTS: HC and HCF were present in 39% and 24% in the derivation cohort and in 44% and 22% in the validation cohort, respectively. HC was predicted with 87% accuracy, yielding an area under ROC curve of 0.95 (95%CI = 0.92-0.98, a positive predictive value of 80% (95%CI = 74-84%, and a negative predictive value of 93% (95%CI = 88-96%. Corresponding figures for HCF were: accuracy 83%, area under ROC curve 0.92 (95%CI = 0.88-0.96, positive predictive value 59% (95%CI = 52-62%, and negative predictive value 97% (95%CI = 93-99%. External validation expectedly resulted in some loss of test performance, preferentially affecting positive predictive rather than negative predictive values. CONCLUSION: Using a clinical prediction rule composed of clinical variables available at birth, HC and HCF could be predicted with good test characteristics in preterm newborns. Further studies should evaluate the clinical value of these rules to guide early treatment individualisation.

Basic stress analysis

CERN Document Server

Iremonger, M J

1982-01-01

BASIC Stress Analysis aims to help students to become proficient at BASIC programming by actually using it in an important engineering subject. It also enables the student to use computing as a means of learning stress analysis because writing a program is analogous to teaching-it is necessary to understand the subject matter. The book begins by introducing the BASIC approach and the concept of stress analysis at first- and second-year undergraduate level. Subsequent chapters contain a summary of relevant theory, worked examples containing computer programs, and a set of problems. Topics c

Health Insurance Basics

Science.gov (United States)

... Staying Safe Videos for Educators Search English Español Health Insurance Basics KidsHealth / For Teens / Health Insurance Basics What's ... thought advanced calculus was confusing. What Exactly Is Health Insurance? Health insurance is a plan that people buy ...

Latin America Region: Between Dependence and Autonomy in Regional Processes

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Wendy Vaca Hernández

2017-01-01

Full Text Available The space called Latin America has a particular history marked by centuries of colonialism and coloniality. The latter concept implies that the basic structure of the colonial system has not changed even though formal independence has been achieved. For this reason, the subcontinent has fluctuated between dependence and the quest for autonomy. These successive cycles have manifested themselves both in the internal configurations and in the regional schemes that have been undertaken. This paper analyzes the construction and evolution of the idea of a region: Latin America and the Caribbean. To that end it examines the concepts of region, regionalism, what Latin America and the Caribbean implies, and what are the transformations in these ideas that have emerged from the regional configurations of the Union of South American Nations (UNASUR and the Community of Latin American and Caribbean States (CELAC as plural organisms with broad objectives.

DNA binding specificity of the basic-helix-loop-helix protein MASH-1.

Science.gov (United States)

Meierhan, D; el-Ariss, C; Neuenschwander, M; Sieber, M; Stackhouse, J F; Allemann, R K

1995-09-05

Despite the high degree of sequence similarity in their basic-helix-loop-helix (BHLH) domains, MASH-1 and MyoD are involved in different biological processes. In order to define possible differences between the DNA binding specificities of these two proteins, we investigated the DNA binding properties of MASH-1 by circular dichroism spectroscopy and by electrophoretic mobility shift assays (EMSA). Upon binding to DNA, the BHLH domain of MASH-1 underwent a conformational change from a mainly unfolded to a largely alpha-helical form, and surprisingly, this change was independent of the specific DNA sequence. The same conformational transition could be induced by the addition of 20% 2,2,2-trifluoroethanol. The apparent dissociation constants (KD) of the complexes of full-length MASH-1 with various oligonucleotides were determined from half-saturation points in EMSAs. MASH-1 bound as a dimer to DNA sequences containing an E-box with high affinity KD = 1.4-4.1 x 10(-14) M2). However, the specificity of DNA binding was low. The dissociation constant for the complex between MASH-1 and the highest affinity E-box sequence (KD = 1.4 x 10(-14) M2) was only a factor of 10 smaller than for completely unrelated DNA sequences (KD = approximately 1 x 10(-13) M2). The DNA binding specificity of MASH-1 was not significantly increased by the formation of an heterodimer with the ubiquitous E12 protein. MASH-1 and MyoD displayed similar binding site preferences, suggesting that their different target gene specificities cannot be explained solely by differential DNA binding. An explanation for these findings is provided on the basis of the known crystal structure of the BHLH domain of MyoD.

Buying food on sale: a mixed methods study with shoppers at an urban supermarket, Philadelphia, Pennsylvania, 2010-2012.

Science.gov (United States)

Phipps, Etienne J; Kumanyika, Shiriki K; Stites, Shana D; Singletary, S Brook; Cooblall, Clarissa; DiSantis, Katherine Isselmann

2014-09-04

The obesity epidemic has drawn attention to food marketing practices that may increase the likelihood of caloric overconsumption and weight gain. We explored the associations of discounted prices on supermarket purchases of selected high-calorie foods (HCF) and more healthful, low-calorie foods (LCF) by a demographic group at high risk of obesity. Our mixed methods design used electronic supermarket purchase data from 82 low-income (primarily African American female) shoppers for households with children and qualitative data from focus groups with demographically similar shoppers. In analyses of 6,493 food purchase transactions over 65 weeks, the odds of buying foods on sale versus at full price were higher for grain-based snacks, sweet snacks, and sugar-sweetened beverages (odds ratios: 6.6, 5.9, and 2.6, respectively; all P snacks. The odds of buying foods on sale versus full price were not higher for any of any of the LCF (P ≥ .07). Without controlling for quantities purchased, we found that spending increased as percentage saved from the full price increased for all HCF and for fruits and vegetables (P ≤ .002). Focus group participants emphasized the lure of sale items and took advantage of sales to stock up. Strategies that shift supermarket sales promotions from price reductions for HCF to price reductions for LCF might help prevent obesity by decreasing purchases of HCF.

Microstructure characteristics and temperature-dependent high cycle fatigue behavior of advanced 9% Cr/CrMoV dissimilarly welded joint

International Nuclear Information System (INIS)

Wu, Qingjun; Lu, Fenggui; Cui, Haichao; Ding, Yuming; Liu, Xia; Gao, Yulai

2014-01-01

Advanced 9% Cr and CrMoV steels chosen as candidate materials are first welded by narrow-gap submerged arc welding (NG-SAW) to fabricate the heavy section rotor. The present work focuses on studying the high-cycle fatigue (HCF) behavior of advanced 9% Cr/CrMoV dissimilarly welded joint at different temperatures. Conditional fatigue strength of this dissimilarly welded joint was obtained by HCF tests at room temperature (RT), 400 °C and 470 °C. It was observed that the failure occurred at the side of CrMoV base metal (BM), weld metal (WM) and heat affected zone (HAZ) of CrMoV side over 5×10 7 cycles for the specimens tested at RT, 400 °C and 470 °C. The detailed microstructures of BMs, WMs and HAZs as well as fracture appearance were observed by optical microscopy (OM) and scanning electron microscopy (SEM). Precipitation and aggregation of carbides along the grain boundaries were clearly detected with the increase of temperature, which brought a negative effect on the fatigue properties. It is interesting to note that the inclusion size leading to crack initiation became smaller for the HCF test at higher temperature. Therefore, reduction in the inclusion size in a welded joint helps to improve the HCF performance at high temperature

Microstructure characteristics and temperature-dependent high cycle fatigue behavior of advanced 9% Cr/CrMoV dissimilarly welded joint

Energy Technology Data Exchange (ETDEWEB)

Wu, Qingjun [Shanghai Key Laboratory of Materials Laser Processing and Modification, Shanghai Jiao Tong University, Shanghai 200240 (China); Lu, Fenggui, E-mail: Lfg119@sjtu.edu.cn [Shanghai Key Laboratory of Materials Laser Processing and Modification, Shanghai Jiao Tong University, Shanghai 200240 (China); Shanghai Key Laboratory of Modern Metallurgy and Materials Processing, Shanghai University, Shanghai 200072 (China); Cui, Haichao [Shanghai Key Laboratory of Materials Laser Processing and Modification, Shanghai Jiao Tong University, Shanghai 200240 (China); Ding, Yuming; Liu, Xia [Shanghai Turbine Plant of Shanghai Electric Power Generation Equipment Co. Ltd., Shanghai 200240 (China); Gao, Yulai, E-mail: ylgao@shu.edu.cn [Shanghai Key Laboratory of Modern Metallurgy and Materials Processing, Shanghai University, Shanghai 200072 (China)

2014-10-06

Advanced 9% Cr and CrMoV steels chosen as candidate materials are first welded by narrow-gap submerged arc welding (NG-SAW) to fabricate the heavy section rotor. The present work focuses on studying the high-cycle fatigue (HCF) behavior of advanced 9% Cr/CrMoV dissimilarly welded joint at different temperatures. Conditional fatigue strength of this dissimilarly welded joint was obtained by HCF tests at room temperature (RT), 400 °C and 470 °C. It was observed that the failure occurred at the side of CrMoV base metal (BM), weld metal (WM) and heat affected zone (HAZ) of CrMoV side over 5×10{sup 7} cycles for the specimens tested at RT, 400 °C and 470 °C. The detailed microstructures of BMs, WMs and HAZs as well as fracture appearance were observed by optical microscopy (OM) and scanning electron microscopy (SEM). Precipitation and aggregation of carbides along the grain boundaries were clearly detected with the increase of temperature, which brought a negative effect on the fatigue properties. It is interesting to note that the inclusion size leading to crack initiation became smaller for the HCF test at higher temperature. Therefore, reduction in the inclusion size in a welded joint helps to improve the HCF performance at high temperature.

Modal characteristics and fatigue strength of compressor blades

International Nuclear Information System (INIS)

Kim, Kyung Kook; Lee, Young Shin

2014-01-01

High-cycle fatigue (HCF) has been identified as one of the primary causes of gas turbine engine failure. The modal characteristics and endurance strength of a 5 MW gas turbine engine blade developed by Doosan Heavy Industries and Construction Co., Ltd. in HCF fracture were verified through analysis and tests to determine the reliability of the compressor blade. A compressor blade design procedure that considers HCF life was performed in the following order: airfoil and blade profile design, modal analysis, stress distribution test, stress endurance limit test, and fatigue life verification. This study analyzed the Campbell diagram and estimated resonance risk on the basis of the natural frequency analysis and modal test of the compressor blade to guarantee safe and operational reliability. In addition, the maximum stress point of the compressor blade was determined through stress distribution analysis and test. The bonding point of the strain gage was determined by using fatigue test. Stress endurance limit test was performed based on the results of these tests. This research compared and verified the modal characteristics and endurance strengths of the compressor blades to prevent HCF fracture, which is among the major causes of gas turbine engine damage. A fatigue life design procedure of compressor blades was established. The 5 MW class gas turbine compressor blade is well designed in terms of resonance stability and fatigue endurance limit.

Modal characteristics and fatigue strength of compressor blades

Energy Technology Data Exchange (ETDEWEB)

Kim, Kyung Kook [Doosan Heavy Industries and Construction, Changwon (Korea, Republic of); Lee, Young Shin [Chungnam National University, Daejeon (Korea, Republic of)

2014-04-15

High-cycle fatigue (HCF) has been identified as one of the primary causes of gas turbine engine failure. The modal characteristics and endurance strength of a 5 MW gas turbine engine blade developed by Doosan Heavy Industries and Construction Co., Ltd. in HCF fracture were verified through analysis and tests to determine the reliability of the compressor blade. A compressor blade design procedure that considers HCF life was performed in the following order: airfoil and blade profile design, modal analysis, stress distribution test, stress endurance limit test, and fatigue life verification. This study analyzed the Campbell diagram and estimated resonance risk on the basis of the natural frequency analysis and modal test of the compressor blade to guarantee safe and operational reliability. In addition, the maximum stress point of the compressor blade was determined through stress distribution analysis and test. The bonding point of the strain gage was determined by using fatigue test. Stress endurance limit test was performed based on the results of these tests. This research compared and verified the modal characteristics and endurance strengths of the compressor blades to prevent HCF fracture, which is among the major causes of gas turbine engine damage. A fatigue life design procedure of compressor blades was established. The 5 MW class gas turbine compressor blade is well designed in terms of resonance stability and fatigue endurance limit.

7. International Frumkin Symposium. Basic electrochemistry for science and technology. Abstracts. Part 2

International Nuclear Information System (INIS)

2000-01-01

Modern tendencies of development of electrochemistry as in regions of fundamental investigations so in applied directions are presented. Basic themes of reports presented are: electrocatalysis and electrosynthesis, batteries and supercapacitors, corrosion and electrodeposition, electrolytes and membranes, biosensors and electroanalysis, nanoelectrochemistry [ru

Clusters and Factors Associated with Complementary Basic Education in Tanzania Mainland

Science.gov (United States)

Edwin, Paul; Amina, Msengwa S.; Godwin, Naimani M.

2017-01-01

Complimentary Basic Education in Tanzania (COBET) is a community-based programme initiated in 1999 to provide formal education system opportunity to over aged children or children above school age. The COBET program was analyzed using secondary data collected from 21 regions from 2008 to 2012. Cluster analysis was applied to classify the 21…

Regional politics of energy savings and instruments of its realization

Directory of Open Access Journals (Sweden)

Simkiv Lilya Yevgenivna

2016-02-01

Full Text Available The article deals with theoretical and methodological foundations and applied aspects of the regional policy of energy saving aimed at the efficient use of energy resources in the region, diversification of energy supplies, modernization of energy infrastructure through the introduction of new technologies and protection of regional interests in the energy sector. The basic approaches and methods for the formation of regional policy of energy saving are determined. It allows deepening and expanding of the basic applied researches, and solving of more complex theoretical and applied problems of regional development. It is mentioned, that the development of regional energy saving policy involves the formation of appropriate legal, financial and credit policy; scientific research, economic, organizational and management measures; advertising and marketing support. It is proved, that for the practical implementation of regional policy the complex combination of economic feasibility, social effectiveness and environmental safety is required.

Nonenzymatic glycosylation of bovine myelin basic protein

International Nuclear Information System (INIS)

Hitz, J.B.

1987-01-01

In the CNS myelin sheath the nonenzymatic glycosylation reaction (at the early stage of the Amadori product) occurs only with the myelin basic protein and not with the other myelin proteins. This was observed in isolated bovine myelin by in vitro incubation with [ 14 C]-galactose and [ 14 C]-glucose. The respective in-vitro incorporation rates for purified bovine myelin basic protein with D-galactose, D-glucose and D-mannose were 7.2, 2.4 and 2.4 mmoles/mole myelin basic protein per day at 37 0 C. A more rapid, HPLC method was devised and characterized to specifically analyze for the Amadori product. The HPLC method was correlated to the [ 14 C]-sugar incorporation method for myelin basic protein under a set of standard reaction conditions using [ 14 C]-glucose and [ 14 C]-mannose with HPLC values at 1/6 and 1/5 of the [ 14 C]-sugar incorporation method. A novel myelin basic protein purification step has been developed that yields a relativity proteolytic free preparation that is easy to work with, being totally soluble at a neutral pH. Nine new spots appear for a trypsinized glycosylated MBP in the paper peptide map of which eight correspond to positions of the [ 3 H]-labeled Amadori product in affinity isolated peptides. These studies provide a general characterization of and a structural basis for investigations on nonenzymatically glycosylated MBP as well as identifying MBP as the only nonenzymatically glycosylated protein in the CNS myelin sheath which may accumulate during aging, diabetes, and demyelinating diseases in general

Recent advances in H-phosphonate chemistry. Part 1. H-phosphonate esters: synthesis and basic reactions.

Science.gov (United States)

Sobkowski, Michal; Kraszewski, Adam; Stawinski, Jacek

2015-01-01

This review covers recent progress in the preparation of H-phosphonate mono- and diesters, basic studies on mechanistic and stereochemical aspects of this class of phosphorus compounds, and their fundamental chemistry in terms of transformation of P-H bonds into P-heteroatom bonds. Selected recent applications of H-phosphonate derivatives in basic organic phosphorus chemistry and in the synthesis of biologically important phosphorus compounds are also discussed.

Basic terminology in the field of mine dusts:Q1 noxious to the health of miners

Energy Technology Data Exchange (ETDEWEB)

Piskorska-Kalisz, Z; Gruszka, J

1979-07-01

Forty five basic terms concerning mine dusts and fighting mine dusts are presented. The terms define various kinds of mine dusts (among others, coal dust), dustiness in underground mines, prediction and measurement of dustiness, composition of mine dusts and grain size distribution of mine dusts and fighting coal dust by spraying water mixed with chemical agents (wetting agents). It is noted that the precise definition of the basic terms in Poland is necessary for clarity. The basic terms have been explained in various publications. The last Encylopaedic Dictionary of Mining was published in Poland in 1955. (In Polish)

Basic hypergeometric functions and covariant spaces for even-dimensional representations of Uq[osp(1/2)

International Nuclear Information System (INIS)

Aizawa, N; Chakrabarti, R; Mohammed, S S Naina; Segar, J

2007-01-01

Representations of the quantum superalgebra U q [osp(1/2)] and their relations to the basic hypergeometric functions are investigated. We first establish Clebsch-Gordan decomposition for the superalgebra U q [osp(1/2)] in which the representations having no classical counterparts are incorporated. Formulae for these Clebsch-Gordan coefficients are derived, and is observed that they may be expressed in terms of the Q-Hahn polynomials. We next investigate representations of the quantum supergroup OSp q (1/2) which are not well defined in the classical limit. Employing the universal T-matrix, the representation matrices are obtained explicitly, and found to be related to the little Q-Jacobi polynomials. Characteristically, the relation Q = -q is satisfied in all cases. Using the Clebsch-Gordan coefficients derived here, we construct new noncommutative spaces that are covariant under the coaction of the even-dimensional representations of the quantum supergroup OSp q (1/2)

Local and regional minimum 1D models for earthquake location and data quality assessment in complex tectonic regions: application to Switzerland

International Nuclear Information System (INIS)

Husen, S.; Clinton, J. F.; Kissling, E.

2011-01-01

One-dimensional (1D) velocity models are still widely used for computing earthquake locations at seismological centers or in regions where three-dimensional (3D) velocity models are not available due to the lack of data of sufficiently high quality. The concept of the minimum 1D model with appropriate station corrections provides a framework to compute initial hypocenter locations and seismic velocities for local earthquake tomography. Since a minimum 1D model represents a solution to the coupled hypocenter-velocity problem it also represents a suitable velocity model for earthquake location and data quality assessment, such as evaluating the consistency in assigning pre-defined weighting classes and average picking error. Nevertheless, the use of a simple 1D velocity structure in combination with station delays raises the question of how appropriate the minimum 1D model concept is when applied to complex tectonic regions with significant three-dimensional (3D) variations in seismic velocities. In this study we compute one regional minimum 1D model and three local minimum 1D models for selected subregions of the Swiss Alpine region, which exhibits a strongly varying Moho topography. We compare the regional and local minimum 1D models in terms of earthquake locations and data quality assessment to measure their performance. Our results show that the local minimum 1D models provide more realistic hypocenter locations and better data fits than a single model for the Alpine region. We attribute this to the fact that in a local minimum 1D model local and regional effects of the velocity structure can be better separated. Consequently, in tectonically complex regions, minimum 1D models should be computed in sub-regions defined by similar structure, if they are used for earthquake location and data quality assessment. (authors)

Local and regional minimum 1D models for earthquake location and data quality assessment in complex tectonic regions: application to Switzerland

Energy Technology Data Exchange (ETDEWEB)

Husen, S.; Clinton, J. F. [Swiss Seismological Service, ETH Zuerich, Zuerich (Switzerland); Kissling, E. [Institute of Geophysics, ETH Zuerich, Zuerich (Switzerland)

2011-10-15

One-dimensional (1D) velocity models are still widely used for computing earthquake locations at seismological centers or in regions where three-dimensional (3D) velocity models are not available due to the lack of data of sufficiently high quality. The concept of the minimum 1D model with appropriate station corrections provides a framework to compute initial hypocenter locations and seismic velocities for local earthquake tomography. Since a minimum 1D model represents a solution to the coupled hypocenter-velocity problem it also represents a suitable velocity model for earthquake location and data quality assessment, such as evaluating the consistency in assigning pre-defined weighting classes and average picking error. Nevertheless, the use of a simple 1D velocity structure in combination with station delays raises the question of how appropriate the minimum 1D model concept is when applied to complex tectonic regions with significant three-dimensional (3D) variations in seismic velocities. In this study we compute one regional minimum 1D model and three local minimum 1D models for selected subregions of the Swiss Alpine region, which exhibits a strongly varying Moho topography. We compare the regional and local minimum 1D models in terms of earthquake locations and data quality assessment to measure their performance. Our results show that the local minimum 1D models provide more realistic hypocenter locations and better data fits than a single model for the Alpine region. We attribute this to the fact that in a local minimum 1D model local and regional effects of the velocity structure can be better separated. Consequently, in tectonically complex regions, minimum 1D models should be computed in sub-regions defined by similar structure, if they are used for earthquake location and data quality assessment. (authors)

From basic needs to basic rights.

Science.gov (United States)

Facio, A

1995-06-01

After arriving at an understanding that basic rights refer to all human needs, it is clear that a recognition of the basic needs of female humans must precede the realization of their rights. The old Women in Development (WID) framework only understood women's needs from an androcentric perspective which was limited to practical interests. Instead, women's primary need is to be free from their subordination to men. Such an understanding places all of women's immediate needs in a new light. A human rights approach to development would see women not as beneficiaries but as people entitled to enjoy the benefits of development. Discussion of what equality before the law should mean to women began at the Third World Conference on Women in Nairobi where the issue of violence against women was first linked to development. While debate continues about the distinction between civil and political rights and economic, social, and cultural rights, the realities of women's lives do not permit such a distinction. The concept of the universality of human rights did not become codified until the UN proclaimed the Universal Declaration of Human Rights in 1948. The declaration has been criticized by feminists because the view of human rights it embodies has been too strongly influenced by a liberal Western philosophy which stresses individual rights and because it is ambiguous on the distinction between human rights and the rights of a citizen. The protection of rights afforded by the Declaration, however, should not be viewed as a final achievement but as an ongoing struggle. International conferences have led to an analysis of the human-rights approach to sustainable development which concludes that women continue to face the routine denial of their rights. Each human right must be redefined from the perspective of women's needs, which must also be redefined. Women must forego challenging the concept of the universality of human rights in order to overcome the argument of cultural

Education: The Basics. The Basics

Science.gov (United States)

Wood, Kay

2011-01-01

Everyone knows that education is important, we are confronted daily by discussion of it in the media and by politicians, but how much do we really know about education? "Education: The Basics" is a lively and engaging introduction to education as an academic subject, taking into account both theory and practice. Covering the schooling system, the…

Body Basics Library

Science.gov (United States)

... Body Basics articles explain just how each body system, part, and process works. Use this medical library to find out about basic human anatomy, how ... Teeth Skin, Hair, and Nails Spleen and Lymphatic System ... Visit the Nemours Web site. Note: All information on TeensHealth® is for ...

Western Pond Turtle Observations - Region 1 [ds313

Data.gov (United States)

California Natural Resource Agency — This dataset was developed in an effort to compile Western Pond Turtle (Clemmys marmorata) observations in CDFG Region 1. Steve Burton (CDFG Staff Environmental...

NS maize hybrids in production regions of Serbia

Directory of Open Access Journals (Sweden)

Stojaković Milisav

2010-01-01

Full Text Available Fifteen NS maize hybrids of FAO 300-700 maturity groups were evaluated in strip trials (plot size 1,120 m2 at 30 locations in Serbia. In all locations including all production regions, the most yielding hybrid was NS 6030 with average yield of 10.9 t ha-1. The additive Main Effects and Multiplicative Interaction (AMMI and the sites regression (SREG models were used to study basic structure of G x E interactions and the possible existence of different mega-environments in Serbian maize growing regions in 2009. The results of the 15 hybrids x 10 locations for grain yield in maize showed by biplot technique indicate several specific location-hybrid deviations (the AMMI biplot, and possible existence of at least one mega-environment (the GGE biplot. .

Development of Electrically Switched Ion Exchange Process for Selective Ion Separations

International Nuclear Information System (INIS)

Rassat, Scot D.; Sukamto, Johanes H.; Orth, Rick J.; Lilga, Michael A.; Hallen, Richard T.

1999-01-01

The electrically switched ion exchange (ESIX) process, being developed at Pacific Northwest National Laboratory, provides an alternative separation method to selectively remove ions from process and waste streams. In the ESIX process, in which an electroactive ion exchange film is deposited onto a high surface area electrode, uptake and elution are controlled directly by modulating the electrochemical potential of the film. This paper addresses engineering issues necessary to fully develop ESIX for specific industrial alkali cation separation challenges. The cycling and chemical stability and alkali cation selectivity of nickel hexacyanoferrate (NiHCF) electroactive films were investigated. The selectivity of NiHCF was determined using cyclic voltammetry and a quartz crystal microbalance to quantify ion uptake in the film. Separation factors indicated a high selectivity for cesium and a moderate selectivity for potassium in high sodium content solutions. A NiHCF film with improved redox cycling and chemical stability in a simulated pulp mill process stream, a targeted application for ESIX, was also prepared and tested

Buying Food on Sale: A Mixed Methods Study With Shoppers at an Urban Supermarket, Philadelphia, Pennsylvania, 2010–2012

Science.gov (United States)

Kumanyika, Shiriki K.; Stites, Shana D.; Singletary, S. Brook; Cooblall, Clarissa; DiSantis, Katherine Isselmann

2014-01-01

Introduction The obesity epidemic has drawn attention to food marketing practices that may increase the likelihood of caloric overconsumption and weight gain. We explored the associations of discounted prices on supermarket purchases of selected high-calorie foods (HCF) and more healthful, low-calorie foods (LCF) by a demographic group at high risk of obesity. Methods Our mixed methods design used electronic supermarket purchase data from 82 low-income (primarily African American female) shoppers for households with children and qualitative data from focus groups with demographically similar shoppers. Results In analyses of 6,493 food purchase transactions over 65 weeks, the odds of buying foods on sale versus at full price were higher for grain-based snacks, sweet snacks, and sugar-sweetened beverages (odds ratios: 6.6, 5.9, and 2.6, respectively; all P supermarket sales promotions from price reductions for HCF to price reductions for LCF might help prevent obesity by decreasing purchases of HCF. PMID:25188276

Ultramicrosensors based on transition metal hexacyanoferrates for scanning electrochemical microscopy

Directory of Open Access Journals (Sweden)

Maria A. Komkova

2013-10-01

Full Text Available We report here a way for improving the stability of ultramicroelectrodes (UME based on hexacyanoferrate-modified metals for the detection of hydrogen peroxide. The most stable sensors were obtained by electrochemical deposition of six layers of hexacyanoferrates (HCF, more specifically, an alternating pattern of three layers of Prussian Blue and three layers of Ni–HCF. The microelectrodes modified with mixed layers were continuously monitored in 1 mM hydrogen peroxide and proved to be stable for more than 5 h under these conditions. The mixed layer microelectrodes exhibited a stability which is five times as high as the stability of conventional Prussian Blue-modified UMEs. The sensitivity of the mixed layer sensor was 0.32 A·M−1·cm−2, and the detection limit was 10 µM. The mixed layer-based UMEs were used as sensors in scanning electrochemical microscopy (SECM experiments for imaging of hydrogen peroxide evolution.

Homoisoflavonoids and Chalcones Isolated from Haematoxylum campechianum L., with Spasmolytic Activity

Directory of Open Access Journals (Sweden)

Armando Escobar-Ramos

2017-08-01

Full Text Available Haematoxylum campechianum is a medicinal plant employed as an astringent to purify the blood and to treat stomach problems such as diarrhea and dysentery. A bio-guided chemical fractionation of the methanolic extract obtained from this plant allowed for the isolation of five compounds: two chalcones known as sappanchalcone (1; 3-deoxysappanchalcone (2; three homoisoflavonoids known as hematoxylol A (3; 4-O-methylhematoxylol (4; and, hematoxin (5. The spasmolytic activity was determined in an in vitro model (electrically induced contractions of guinea pig ileum, and allowed to demonstrate that the methanolic extract (EC50 = 62.11 ± 3.23 fractions HcF7 (EC50 = 61.75 ± 3.55 and HcF9 (EC50 = 125.5 ± 10.65 and compounds 1 (EC50 = 16.06 ± 2.15 and 2 (EC50 = 25.37 ± 3.47 of Haematoxylum campechianum present significant relaxing activity as compared to papaverine (EC50 = 20.08 ± 2.0 as a positive control.

Basic electronics

CERN Document Server

Holbrook, Harold D

1971-01-01

Basic Electronics is an elementary text designed for basic instruction in electricity and electronics. It gives emphasis on electronic emission and the vacuum tube and shows transistor circuits in parallel with electron tube circuits. This book also demonstrates how the transistor merely replaces the tube, with proper change of circuit constants as required. Many problems are presented at the end of each chapter. This book is comprised of 17 chapters and opens with an overview of electron theory, followed by a discussion on resistance, inductance, and capacitance, along with their effects on t

Development and validation of a theoretical test in basic laparoscopy

DEFF Research Database (Denmark)

Strandbygaard, Jeanett; Maagaard, Mathilde; Larsen, Christian Rifbjerg

2013-01-01

for first-year residents in obstetrics and gynecology. This study therefore aimed to develop and validate a framework for a theoretical knowledge test, a multiple-choice test, in basic theory related to laparoscopy. METHODS: The content of the multiple-choice test was determined by conducting informal...... conversational interviews with experts in laparoscopy. The subsequent relevance of the test questions was evaluated using the Delphi method involving regional chief physicians. Construct validity was tested by comparing test results from three groups with expected different clinical competence and knowledge.......001). Internal consistency (Cronbach's alpha) was 0.82. There was no evidence of differential item functioning between the three groups tested. CONCLUSIONS: A newly developed knowledge test in basic laparoscopy proved to have content and construct validity. The formula for the development and validation...

Transcriptional analysis of genetic region RvD1 of Mycobacterium bovis

Directory of Open Access Journals (Sweden)

Víctor Manuel Tibatá R.

2004-07-01

Full Text Available Mycobacterium bovis, shares 99.9% of genomic identity with M. tuberculosis, M. africanum and M. microti. Within this 0.1 % of difference, there are two genetic regions characteristics of M. bovis that are deleted in M. tuberculo­sis H37Rv: RvD1 and RvD2. According to bioinformatic analysis, these regions contain Open Reading Frames (ORFs. With the purpose of determining if the RvD1 region transcribes the ORFs predicted by bioinformatics (ORF1, ORF2 and Rv2024; total RNA was extracted from a culture of M. bovis BCG Pasteur, at different time points along the growth curve. The RNA samples were analyzed by Real Time Reverse Transcription - Poly-merase Chain Reaction (RTq-PCR. The findings show that ORF1, ORF2 and Rv2024, were transcribed consti-tutively, something that has not been reported previously. These results are a first step in order to determine the function of M. bovis RvD1 region, its possible role in pathogenesis and its interaction with both cattle and humans. Key words: Mycobacterium bovis, BCG, RNA, Real Time, RT-PCR, RvD1

Do brain lesions in stroke affect basic emotions and attachment?

Science.gov (United States)

Farinelli, Marina; Panksepp, Jaak; Gestieri, Laura; Maffei, Monica; Agati, Raffaele; Cevolani, Daniela; Pedone, Vincenzo; Northoff, Georg

2015-01-01

The aim of the current study was to investigate basic emotions and attachment in a sample of 86 stroke patients. We included a control group of 115 orthopedic patients (matched for age and cognitive status) without brain lesions to control for unspecific general illness effects of a traumatic recent event on basic emotions and attachment. In order to measure basic emotions and attachment style we applied the Affective Neuroscience Personality Scale (ANPS) and the Attachment Style Questionnaire (ASQ). The stroke patients showed significantly different scores in the SEEKING, SADNESS, and ANGER subscales of the ANPS as well as in the Relationship as Secondary Attachment dimension of the ASQ when compared to the control group. These differences show a pattern influenced by lesion location mainly as concerns basic emotions. Anterior, medial, left, and subcortical patients provide scores significantly lower in ANPS-SEEKING than the control group; ANPS-SADNESS scores in anterior, right, medial, and subcortical patients were significantly higher than those of the control group. ANPS-ANGER scores in posterior, right, and lateral patients were significantly higher than those in the control group; finally, the ANPS-FEAR showed slightly lower scores in posterior patients than in the control group. Minor effects on brain lesions were also individuated in the attachment style. Anterior lesion patients showed a significantly higher average score in the ASQ-Need for Approval subscale than the control group. ASQ-Confidence subscale scores differed significantly in stroke patients with lesions in medial brain regions when compared to control subjects. Scores at ANPS and ASQ subscales appear significantly more correlated in stroke patients than in the control group. Such finding of abnormalities, especially concerning basic emotions in stroke brain-lesioned patients, indicates that the effect of brain lesions may enhance the interrelation between basic emotions and attachment with

A reciprocal effects model of the temporal ordering of basic psychological needs and motivation.

Science.gov (United States)

Martinent, Guillaume; Guillet-Descas, Emma; Moiret, Sophie

2015-04-01

Using self-determination theory as the framework, we examined the temporal ordering between satisfaction and thwarting of basic psychological needs and motivation. We accomplished this goal by using a two-wave 7-month partial least squares path modeling approach (PLS-PM) among a sample of 94 adolescent athletes (Mage = 15.96) in an intensive training setting. The PLS-PM results showed significant paths leading: (a) from T1 satisfaction of basic psychological need for competence to T2 identified regulation, (b) from T1 external regulation to T2 thwarting and satisfaction of basic psychological need for competence, and (c) from T1 amotivation to T2 satisfaction of basic psychological need for relatedness. Overall, our results suggest that the relationship between basic psychological need and motivation varied depending on the type of basic need and motivation assessed. Basic psychological need for competence predicted identified regulation over time whereas amotivation and external regulation predicted basic psychological need for relatedness or competence over time.

Novel Basic Mesoporous Catalysts for Friedländer Reaction from 2-Aminoaryl Ketones: Quinolin-2(1H)-ones vs. Quinolines

Czech Academy of Sciences Publication Activity Database

Domínguez-Fernández, F.; López-Sanz, J.; Pérez-Mayoral, E.; Bek, David; Martín-Aranda, R. M.; López-Peinado, A. J.; Čejka, Jiří

2009-01-01

Roč. 1, č. 2 (2009), s. 241-243 ISSN 1867-3880 R&D Projects: GA AV ČR KAN100400701 Institutional research plan: CEZ:AV0Z40400503 Keywords : quinolines * heterogeneous catalysis * basicity Subject RIV: CF - Physical ; Theoretical Chemistry

Advanced Casting Technology

Science.gov (United States)

1982-08-01

Anodic Films for the Protection of Magnesium Alloys". G.R. Kotler, D.L. Hawke and E.N. Agua . Proc. International Magnesium Association, Montreal, May...HCF testing, impellers were bench tested to assess the in situ fatigue capabilities of 250-C28 impeller airfoils. In this testing, the airfoils...64 at 204oC (400oF), 13- T to a> o >-, o r- i—l CD -*—• Cast Wrought TE-2222 Ficure 11. In situ HCF results for Ti-64 Model 250

Venezuela electoral 2012: escenarios y perspectivas

Directory of Open Access Journals (Sweden)

Juan Manuel Trak Vásquez

2014-06-01

Full Text Available El objetivo de estas líneas es reflexionar sobre los posibles escenarios que se pueden dar en Venezuela a partir de las elecciones presidenciales del 7 de octubre, en donde se juega la reelección de Hugo Chávez Frías (HCF. Para ello es necesario hacer un breve recorrido por la historia política reciente de Venezuela, cómo llega HCF al poder y los hitos más importantes que han marcado sus mandatos desde 1998.

Basic Research Firing Facility

Data.gov (United States)

Federal Laboratory Consortium — The Basic Research Firing Facility is an indoor ballistic test facility that has recently transitioned from a customer-based facility to a dedicated basic research...

Characterization of Hepatitis C Virus genotype 3a Hypervariable region 1 in patients achieved rapid virological response to alpha interferon and Ribavirin Combination therapy

Directory of Open Access Journals (Sweden)

Badar Sadaf

2011-05-01

Full Text Available Abstract Background Hepatitis C virus roots a chronic liver disease. Currently approved treatment strategy includes administration of alpha interferon and ribavirin combined therapy for 24-48 weeks. One of the predictor of sustained virological response is an early virological response to treatment characterized as rapid response. Hyper variable region 1 (HVR1 of E2 protein is responsible for viral entry and acts as a target for neutralizing antibodies. Any mutation in this region would effect virus interaction with target cell and viral persistence. Methods Thirty one clones of six pre-treatment samples subjected to combination therapy were investigated. Three of the patients were rapid responders (R1, R2 and R3 and two were breakthrough responders (BT1 and BT2. Envelope 2 gene was amplified, cloned and sequenced. Amino acid substitution, frequency, composition and antigenic properties of HVR 1 of E2 protein were studied. Results In both rapid responders (R.R (14 amino acid sites and breakthrough responders (BT.R (13 amino acid sites half of the amino acid sites were either conserved or resistant to any physiochemical change due to amino acid substitution. It also indicated that average composition of hydrophilic and basic amino acids were comparatively lower in rapid responders than other samples affecting probable interaction of virus with target cells. A central non antigenic region was constant among the breakthrough responders but differed in length significantly among rapid responders reflecting the adaptive nature of HVR1 to the immune response. Conclusions We observed that although HVR1is quite variable region in HCV 3a patients responding differently to treatment it still maintains its physiochemical properties for its proper functioning and viability.

Epidemiological networks and drug resistance of HIV type 1 in Krasnoyarsk region, Russia

NARCIS (Netherlands)

Rumyantseva, Olga A.; Olkhovskiy, Igor A.; Malysheva, Marina A.; Ruzaeva, Ludmila A.; Vasiliev, Alexander V.; Kazennova, Elena V.; Bobkova, Marina R.; Lukashov, Vladimir V.

2009-01-01

To study the molecular epidemiology of HIV-1 in Krasnoyarsk region, Russia, where HIV-1 has spread rapidly since 2000, we obtained pol sequences from individuals living in this region (n = 67) as well as in the geographically closely related Altay region (n = 13). In both regions, subtype A viruses

Stand structure, composition and illegal logging in selectively logged production forests of Myanmar: Comparison of two compartments subject to different cutting frequency

Directory of Open Access Journals (Sweden)

Tual Cin Khai

2016-07-01

Full Text Available Appropriate cutting cycles and annual allowable cuts are crucial to ensure sustainability of tropical selective logging, but there have been limited field data to verify long-term effects of different cutting cycles. This study reveals some evidence of forest degradation in selectively logged production forests of Myanmar, which are subject to inappropriate cutting frequency. We compared stand structure, commercial species composition, and incidence of illegal logging between two compartments with low (LCF; 1 time and high (HCF; 5 times cutting frequency over a recent 18 years. Prior to the latest cutting, LCF had 176 trees ha−1 with an inverted-J shape distribution of diameter at breast height (DBH, including a substantial amount of teak (Tectona grandis and other commercially important species in each DBH class. HCF prior to the latest cut had only 41 trees ha−1 without many commercially important species. At HCF, nearly half the standing trees of various species and size were illegally cut following legal operations; this was for charcoal making in nearby kilns. At LCF, two species, teak and Xylia xylocarpa, were cut illegally and sawn for timber on the spot. More extensive and systematic surveys are needed to generalize the findings of forest degradation and illegal logging. However, our study calls for urgent reconsideration of logging practices with high cutting frequency, which can greatly degrade forests with accompanying illegal logging, and for rehabilitating strongly degraded, bamboo-dominated forests. To reduce illegal logging, it would be important to pay more attention on a MSS regulation stating that logging roads should be destroyed after logging operations.

Functional Analysis of Promoter Region from Eel Cytochrome P450 1A1 Gene in Transgenic Medaka.

Science.gov (United States)

Ogino; Itakura; Kato; Aoki; Sato

1999-07-01

: Transcription of the CYP1A1 genes in mammals and fish is stimulated by polyaromatic hydrocarbons. DNA sequencing analysis revealed that CYP1A1 gene in eel (Anguilla japonica) contains two kinds of putative cis-acting regulatory elements, XRE (xenobiotic-responsive element) and ERE (estrogen-responsive element). XRE is known as the enhancer that is responsible for the inducibility of the genes of CYP1A1 and some other drug-metabolizing enzymes. In the eel CYP1A1 gene, XRE motifs are distributed as follows: five times in the region from -2136 to -1125 bp, XRE(-6) to (-2); once in the proximal basal promoter region, XRE(-1); and once in the first intron, XRE(+1). The region between XRE(-2) and XRE(-1) contains three ERE motifs. To investigate the function of the cis-acting regulatory elements in the eel CYP1A1 gene, recombinant plasmids prepared with its 5' upstream sequence and the structural gene for luciferase were microinjected into fertilized eggs of medaka at the one-cell stage. Hatched fry were treated with 3-methylcholanthrene, and the transcription efficiency was assayed using competitive polymerase chain reaction analysis. Deletion of the region containing the five XREs, XRE(-6) to XRE(-2), and the point mutation of XRE(-1) reduced the inducible expressions by 75% and 56%, respectively, showing apparent dependency of the drug induction on the XREs. Constitutive expression, however, was not significantly affected by deletion or disruption of the XREs. When the region between XRE(-2) and XRE(-1) containing no XREs but three ERE motifs was internally deleted, the inducible expression and the constitutive expression were reduced by 88% and 75%, respectively. Replacement of this region with a partial fragment of eel CYP1A1 complementary DNA, with slight alteration of the distance between the five XREs and XRE(-1), reduced the inducible expression and the constitutive expression by 91% and 60%, respectively. These results strongly suggest that not only XRE but

f-Element Ion Chelation in Highly Basic Media

International Nuclear Information System (INIS)

Paine, R.T.

2000-01-01

A large body of data has been collected over the last fifty years on the chemical behavior of f-element ions. The ions undergo rapid hydrolysis reactions in neutral or basic aqueous solutions that produce poorly understood oxide-hydroxide species; therefore, most of the fundamental f-element solution chemistry has allowed synthetic and separations chemists to rationally design advanced organic chelating ligands useful for highly selective partitioning and separation of f-element ions from complex acidic solution matrices. These ligands and new examples under development allow for the safe use and treatment of solutions containing highly radioactive species. This DOE/EMSP project was undertaken to address the following fundamental objectives: (1) study the chemical speciation of Sr and lanthanide (Ln) ions in basic aqueous media containing classical counter anions found in waste matrices; (2) prepare pyridine N-oxide phosphonates and phosphonic acids that might act as selective chelators for Ln ions in model basic pH waste streams; (3) study the binding of the new chelators toward Ln ions and (4) examine the utility of the chelators as decontamination and dissolution agents under basic solution conditions. The project has been successful in attacking selected aspects of the very difficult problems associated with basic pH solution f-element waste chemistry. In particular, the project has (1) shed additional light on the initial stages of Ln ion sol-gel-precipitate formulation under basic solution conditions; (2) generated new families of pyridine phosphonic acid chelators; (3) characterized the function of the chelators and (4) examined their utility as oxide-hydroxide dissolution agents. These findings have contributed significantly to an improved understanding of the behavior of Ln ions in basic media containing anions found in typical waste sludges as well as to the development of sludge dissolution agents. The new chelating reagents are easily made and could be

Development of the Multilingual Collaboration System for Farmers of Several Counntries (1) : Application of Basic Terminology Translation Dictionary

OpenAIRE

Lee, Kang Oh; Nakaji, Kei; Nada, Yoichi

2004-01-01

In order to share agricultural information through the Internet, the multilingual collaboratioin system of agricultural productioni was developed for farmers of many countries. The basic terminology translationi dictionary was developed by using several open source programs and free software to translate the basic terminology of multilingual collaboration system. The basic terminology translationi dictionaru was composed of about 4200 terms in Japanese, Korean and English including 2700 horti...

Basic radiation oncology

International Nuclear Information System (INIS)

Beyzadeoglu, M. M.; Ebruli, C.

2008-01-01

Basic Radiation Oncology is an all-in-one book. It is an up-to-date bedside oriented book integrating the radiation physics, radiobiology and clinical radiation oncology. It includes the essentials of all aspects of radiation oncology with more than 300 practical illustrations, black and white and color figures. The layout and presentation is very practical and enriched with many pearl boxes. Key studies particularly randomized ones are also included at the end of each clinical chapter. Basic knowledge of all high-tech radiation teletherapy units such as tomotherapy, cyberknife, and proton therapy are also given. The first 2 sections review concepts that are crucial in radiation physics and radiobiology. The remaining 11 chapters describe treatment regimens for main cancer sites and tumor types. Basic Radiation Oncology will greatly help meeting the needs for a practical and bedside oriented oncology book for residents, fellows, and clinicians of Radiation, Medical and Surgical Oncology as well as medical students, physicians and medical physicists interested in Clinical Oncology. English Edition of the book Temel Radyasyon Onkolojisi is being published by Springer Heidelberg this year with updated 2009 AJCC Staging as Basic Radiation Oncology

Basic digital signal processing

CERN Document Server

Lockhart, Gordon B

1985-01-01

Basic Digital Signal Processing describes the principles of digital signal processing and experiments with BASIC programs involving the fast Fourier theorem (FFT). The book reviews the fundamentals of the BASIC program, continuous and discrete time signals including analog signals, Fourier analysis, discrete Fourier transform, signal energy, power. The text also explains digital signal processing involving digital filters, linear time-variant systems, discrete time unit impulse, discrete-time convolution, and the alternative structure for second order infinite impulse response (IIR) sections.

Mitochondrial control region and GSTP1 polymorphism associated ...

African Journals Online (AJOL)

Souvik Ghatak

2016-02-20

Feb 20, 2016 ... were identified in urinary bladder cancer samples in GSTP1 gene. These two heteroplasmic ... also develop into a genetic marker of hereditary urinary blad- der cancer. ..... loop region in human colorectal cancer. Dis Colon ...

[Games as an alternative for teaching basic health concepts].

Science.gov (United States)

Castillo Lizardo, J M; Rodríguez-Morán, M; Guerrero-Romero, F

2001-05-01

To determine, for the teaching of basic health concepts to school-age children, the effectiveness of an educational strategy based on traditional children's games. Intervention study carried out in the city of Durango, Mexico, in June 2000 with 300 children from 9 to 11 years old. The children were randomly divided into two groups. The children in Group A used a modified version of a Mexican popular game called Serpientes y Escaleras (Snakes and Ladders) that included messages on basic health concepts; the children in Group B made up the control group and did not play the modified game. At baseline there were no significant differences between the two groups in terms of age, grade level, or their scores on a knowledge test of basic health concepts. After the educational intervention, the health concepts test scores, out of a maximum possible of 10, were 9.3 +/- 0.8 for Group A and 7.5 +/- 1.1 for Group B (P games that include health and hygiene messages can be an alternative for teaching basic health concepts.

TAIL1: an isthmin-like gene, containing type 1 thrombospondin-repeat and AMOP domain, mapped to ARVD1 critical region.

Science.gov (United States)

Rossi, Valeria; Beffagna, Giorgia; Rampazzo, Alessandra; Bauce, Barbara; Danieli, Gian Antonio

2004-06-23

Isthmins represent a novel family of vertebrate secreted proteins containing one copy of the thrombospondin type 1 repeat (TSR), which in mammals is shared by several proteins with diverse biological functions, including cell adhesion, angiogenesis, and patterning of developing nervous system. We have determined the genomic organization of human TAIL1 (thrombospondin and AMOP containing isthmin-like 1), a novel isthmin-like gene encoding a protein that contains a TSR and a C-terminal AMOP domain (adhesion-associated domain in MUC4 and other proteins), characteristic of extracellular proteins involved in adhesion processes. TAIL1 gene encompasses more than 24.4 kb. Analysis of the DNA sequence surrounding the putative transcriptional start region revealed a TATA-less promoter located in a CpG island. Several consensus binding sites for the transcription factors Sp1 and MZF-1 were identified in this promoter region. In humans, TAIL1 gene is located on chromosome 14q24.3 within ARVD1 (arrhythmogenic right ventricular dysplasia/cardiomyopathy, type 1) critical region; preliminary evidence suggests that it is expressed in several tissues, showing multiple alternative splicing.

38 CFR 3.315 - Basic eligibility determinations; dependents, loans, education.

Science.gov (United States)

2010-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false Basic eligibility determinations; dependents, loans, education. 3.315 Section 3.315 Pensions, Bonuses, and Veterans' Relief... Ratings and Evaluations; Service Connection § 3.315 Basic eligibility determinations; dependents, loans...

From University to Regionality? Knowledge Economy and Regional Development--The Case of Sweden

Science.gov (United States)

From, Jörgen; Olofsson, Anders

2016-01-01

New public management and knowledge economy have become watchwords in the governance of higher education. The university's role has rapidly changed toward regional development. The aim of this article is critically to highlight the basic rationale of this reorganization and to examine what this can mean in a Swedish context. This rationale is…

Vocational Interests and Basic Values.

Science.gov (United States)

Sagiv, Lilach

2002-01-01

Study 1 (n=97) provided evidence of the correlation of Holland's model of vocational interests with Schwartz' theory of basic values. Realistic career interests did not correlate with values. Study 2 (n=545) replicated these findings, showing a better match for individuals who had reached a career decision in counseling than for the undecided.…

Computer Assisted Instruction in Basic.

Science.gov (United States)

1983-09-28

LIBRARY........................16 Program Purpose.........................16 Flowcharts ..........................17 Lessons...17IFlowchart For Main Menu...............19 Flowchart for Lessons One Through Six......................20 CHAPTER Page Tests I1-6 .* 21 Flowchart For...Software support was limited to off-the-shelf packages. All of the computers were purchased with Beginners All Purpose Instruction Code (BASIC), a word

Food Independence of the Region

Directory of Open Access Journals (Sweden)

Vasiliy Vladimirovich Tyutyunik

2016-06-01

Full Text Available The article deals with such basic definitions as food security, food independence and food self- sufficiency of the region. The author shows the ambiguity problem of interpretations of these terms in the Russian legislation, which is especially evident in the transition from the national to the regional level. Using the example of legislative acts of some of the Russian Federation’s subjects the study demonstrates the incorrect use of mentioned terms. In author’s opinion, regional authorities in the Russian Federation must introduce amendments to the legislative documents concerning food security. To be more concrete, the regional authorities should either deny the goal of food independence for a particular region, or specify that the goal of reaching food independence for the region does not mean food self-sufficiency, but just import substitution on the regional level

THEORETICAL AND METHODOLOGICAL APPROACHES TO REGIONAL COMPETITION INVESTIGATION

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A.I. Tatarkin

2006-03-01

Full Text Available The article is dedicated to theoretical-methodological issues of regional economy competitiveness investigation. Economic essence of regional competitiveness is analyzed, its definition is given. The factors that determine relations of competition on medium and macrolevels are proved. The basic differences between world-economical and inter-regional communications are formulated. The specific features of globalization processes as form of competitive struggle are considered.

The Quality of Basic Education as Being of All Human Right

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Beatriz de Lima Fernandes Gottardo

2015-12-01

Full Text Available In this article, we address the question basic education as a right of every human being. To do this, we will use empirical data as well as literature review in the national and international levels. First, the article is talking about an ideal model of quality basic education for all, making general contours of the world stage, to specifically enter the state of education in Brazil. We discuss the text a study of the various existing regulatory provisions in Brazil that deal with the need to ensure quality basic education in an inclusive way that meets the different needs of students in different regions of our country, and thus try to find solutions to the problems we face when trying to bring quality education to all. Finally, we will address issues related to guaranteeing the right to education at the international level, pointing out the legal provisions that guarantee this right and approach the principle of human dignity as a means for the realization of this right.

METHODICAL MODEL FOR TEACHING BASIC SKI TURN

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Danijela Kuna

2013-07-01

Full Text Available With the aim of forming an expert model of the most important operators for basic ski turn teaching in ski schools, an experiment was conducted on a sample of 20 ski experts from different countries (Croatia, Bosnia and Herzegovina and Slovenia. From the group of the most commonly used operators for teaching basic ski turn the experts picked the 6 most important: uphill turn and jumping into snowplough, basic turn with hand sideways, basic turn with clapping, ski poles in front, ski poles on neck, uphill turn with active ski guiding. Afterwards, ranking and selection of the most efficient operators was carried out. Due to the set aim of research, a Chi square test was used, as well as the differences between frequencies of chosen operators, differences between values of the most important operators and differences between experts due to their nationality. Statistically significant differences were noticed between frequencies of chosen operators (c2= 24.61; p=0.01, while differences between values of the most important operators were not obvious (c2= 1.94; p=0.91. Meanwhile, the differences between experts concerning thier nationality were only noticeable in the expert evaluation of ski poles on neck operator (c2=7.83; p=0.02. Results of current research are reflected in obtaining useful information about methodological priciples of learning basic ski turn organization in ski schools.

Basic concept of the nuclear emergency preparedness and response in Japan after the accident of the Fukushima Dai-ichi Nuclear Power Station. The plain explanation for regional officials and emergency workers

International Nuclear Information System (INIS)

Sato, Sohei; Yamamoto, Kazuya

2013-07-01

After the accident of TEPCO's Fukushima Dai-ichi Nuclear Power Station occurred on March 11, 2011, actions for controlling the accident and protective actions for the residents like evacuation were taken. In parallel with this, it has been developed to reform the nuclear regulatory systems and the emergency preparedness and response systems in Japan. Especially the Nuclear Regulation Authority's Nuclear Emergency Preparedness and Response Guidelines were adopted with the introducing the basic concepts and the criteria on the basis of the IAEA's safety standards and differed greatly from the prior guidelines. Thus the arrangement of emergency response systems, resources and the operational procedures will be developed complying with according to the guidelines in municipalities around the nuclear power station sites. This work attempts to provide a plain explanation as possible for the regional officials and emergency workers about the basic concepts of the new guidelines. (author)

Basic principles of diffusion-weighted imaging

International Nuclear Information System (INIS)

Bammer, Roland.

2003-01-01

In diffusion-weighted MRI (DWI), image contrast is determined by the random microscopic motion of water protons. During the last years, DWI has become an important modality in the diagnostic work-up of acute ischemia in the CNS. There are also a few promising reports about the application of DWI to other regions in the human body, such as the vertebral column or the abdomen. This manuscript provides an introduction into the basics of DWI and Diffusion Tensor imaging. The potential of various MR sequences in concert with diffusion preparation are discussed with respect to acquisition speed, spatial resolution, and sensitivity to bulk physiologic motion. More advanced diffusion measurement techniques, such as high angular resolution diffusion imaging, are also addressed

Basic science right, not basic science lite: medical education at a crossroad.

Science.gov (United States)

Fincher, Ruth-Marie E; Wallach, Paul M; Richardson, W Scott

2009-11-01

This perspective is a counterpoint to Dr. Brass' article, Basic biomedical sciences and the future of medical education: implications for internal medicine. The authors review development of the US medical education system as an introduction to a discussion of Dr. Brass' perspectives. The authors agree that sound scientific foundations and skill in critical thinking are important and that effective educational strategies to improve foundational science education should be implemented. Unfortunately, many students do not perceive the relevance of basic science education to clinical practice.The authors cite areas of disagreement. They believe it is unlikely that the importance of basic sciences will be diminished by contemporary directions in medical education and planned modifications of USMLE. Graduates' diminished interest in internal medicine is unlikely from changes in basic science education.Thoughtful changes in education provide the opportunity to improve understanding of fundamental sciences, the process of scientific inquiry, and translation of that knowledge to clinical practice.

The effects of threonine phosphorylation on the stability and dynamics of the central molecular switch region of 18.5-kDa myelin basic protein.

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Kenrick A Vassall

Full Text Available The classic isoforms of myelin basic protein (MBP are essential for the formation and maintenance of myelin in the central nervous system of higher vertebrates. The protein is involved in all facets of the development, compaction, and stabilization of the multilamellar myelin sheath, and also interacts with cytoskeletal and signaling proteins. The predominant 18.5-kDa isoform of MBP is an intrinsically-disordered protein that is a candidate auto-antigen in the human demyelinating disease multiple sclerosis. A highly-conserved central segment within classic MBP consists of a proline-rich region (murine 18.5-kDa sequence -T92-P93-R94-T95-P96-P97-P98-S99- containing a putative SH3-ligand, adjacent to a region that forms an amphipathic α-helix (P82-I90 upon interaction with membranes, or under membrane-mimetic conditions. The T92 and T95 residues within the proline-rich region can be post-translationally modified through phosphorylation by mitogen-activated protein (MAP kinases. Here, we have investigated the structure of the α-helical and proline-rich regions in dilute aqueous buffer, and have evaluated the effects of phosphorylation at T92 and T95 on the stability and dynamics of the α-helical region, by utilizing four 36-residue peptides (S72-S107 with differing phosphorylation status. Nuclear magnetic resonance spectroscopy reveals that both the α-helical as well as the proline-rich regions are disordered in aqueous buffer, whereas they are both structured in a lipid environment (cf., Ahmed et al., Biochemistry 51, 7475-9487, 2012. Thermodynamic analysis of trifluoroethanol-titration curves monitored by circular dichroism spectroscopy reveals that phosphorylation, especially at residue T92, impedes formation of the amphipathic α-helix. This conclusion is supported by molecular dynamics simulations, which further illustrate that phosphorylation reduces the folding reversibility of the α-helix upon temperature perturbation and affect the

Southeastern Regional Environmental Characterization Report. Volume 1. Final report

International Nuclear Information System (INIS)

1985-08-01

This report presents available environmental information pertinent to siting a repository for high-level nuclear waste in crystalline rock in central Maryland; noncoastal Virginia, North Carolina, and South Carolina; and northern Georgia. For each of the States within the Southeastern Region, information is provided on those environmental disqualifying factors and regional screening variables to be used in region-to-area screening. These environmental factors and variables include existing and proposd Federal-protected lands, components of National Forest Lands, proximity to Federal-protected lands, existing State-protected lands, proximity to State-protected lands, population density and distribution, proximity to highly populated areas, or to 1-mile-square areas with 1000 or more persons, national and State forest lands, designated critical habitats for threatened and endangered species, surface water bodies, and wetlands. In addition, supplementary descriptive information providing a general characterization of the region is presented, as is information on environmental parameters that will be of use at later phases of screening. Also included is a discussion of the relationship between the US Department of Energy Siting Guidelines (10 CFR 960) and those environmental disqualifying factors and regional screening variables to be used in the region-to-area screening process

Universal Basic Education and the Provision of Quality Mathematics in Southern Africa

Science.gov (United States)

Kazima, Mercy

2014-01-01

In this paper, I discuss Universal Basic Education (UBE) in relation to the teaching and learning of mathematics in Southern Africa. I present the status of UBE for all countries in the region and then use 3 selected examples: Botswana, Malawi, and Zambia, to illustrate the provision of mathematics in the general framework of UBE in the countries.…

Views of Omani Post-Basic Education Students about Religious and Cultural Tolerance

Science.gov (United States)

Al-Rabaani, Ahmed Hamad

2018-01-01

The study aims to investigate the views of Omani post-basic education students (Grades 10-12) about religious and cultural tolerance. The sample consisted of 1390 male and female students in grades 10, 11 and 12, from four of Oman's seven regions. A questionnaire was used to gather data, which consisted of 27 items divided into five domains. The…

[Courses in basic research methodology a valuable asset for clinicians. Twelve years' experiences in southern Sweden].

Science.gov (United States)

Håkansson, Anders; Lindberg, Eva Pettersson; Henriksson, Karin

2002-03-07

At the Department of Community Medicine at Lund University we have given courses in basic research methodology since 1989. The course has yielded 20 points of university credit, the equivalent of one full-time semester of studies, and it has been run part-time, covering one and a half years. Our aim has been to provide a large number of physicians with basic training in research methods, and to stimulate the engagement of new scientific students from the whole Southern Health Care Region. During the first ten years, 138 general practitioners (20% of the GPs of the region) and 202 specialists completed our courses. Up till now, 19 GPs (14%) and 19 specialists (9%) have begun PhD studies. During the last two years, another 100 physicians from southern Sweden have attended our courses, as well as GPs from Zealand in Denmark. We have been developing our course in basic research methods during a twelve-year period, and it is now well established in our health care region. We feel that we have succeeded in reaching the two goals we had set up: to give a large number of physicians a fundamental knowledge of research methods and to recruit and increase the number of PhD students. We believe that medical research and development must flourish also outside the traditional university settings.

Preparation of 2-acrylamido-2 methyl propane-1-sulfonic acid/bentonite composite by radiation polymerization for adsorption of basic violet dye from aqueous solution

International Nuclear Information System (INIS)

Sokker, H.H.; Younes, M.M.; Abdel-Kareem, M.; Zohdy, K.

2010-01-01

Water uptake and the sorption properties of composite made by radiation polymerization of 2-acrylamido-2- methyl propane -1-sulfonic acid (AMPS) and a clay such as bentonite were investigated as a function of composition (2,6 and 10% w.t %) of bentonite and radiation dose. The prepared composite was characterized by FTIR and SEM. Swelling experiments were performed in water at 25 degree C. The prepared composite was applied for adsorption of basic violet dye at different ph values and the results showed that the prepared composite of composition (10% wt % of bentonite) showed the highest removal percent of basic violet dye at ph=9 compared with other compositions. Also, the adsorption capacity of basic violet at ph 3,7 and 9 were 3.5, 9 and 50 mg/g, respectively. The adsorption process of basic violet follows both Freundlich and Langmuir models and followed pseudo second order kinetic model

Loading of Hip Measured by Hip Contact Forces at Different Speeds of Walking and Running.

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Giarmatzis, Georgios; Jonkers, Ilse; Wesseling, Mariska; Van Rossom, Sam; Verschueren, Sabine

2015-08-01

Exercise plays a pivotal role in maximizing peak bone mass in adulthood and maintaining it through aging, by imposing mechanical loading on the bone that can trigger bone mineralization and growth. The optimal type and intensity of exercise that best enhances bone strength remains, however, poorly characterized, partly because the exact peak loading of the bone produced by the diverse types of exercises is not known. By means of integrated motion capture as an input to dynamic simulations, contact forces acting on the hip of 20 young healthy adults were calculated during walking and running at different speeds. During walking, hip contact forces (HCFs) have a two-peak profile whereby the first peak increases from 4.22 body weight (BW) to 5.41 BW and the second from 4.37 BW to 5.74 BW, by increasing speed from 3 to 6 km/h. During running, there is only one peak HCF that increases from 7.49 BW to 10.01 BW, by increasing speed from 6 to 12 km/h. Speed related profiles of peak HCFs and ground reaction forces (GRFs) reveal a different progression of the two peaks during walking. Speed has a stronger impact on peak HCFs rather than on peak GRFs during walking and running, suggesting an increasing influence of muscle activity on peak HCF with increased speed. Moreover, results show that the first peak of HCF during walking can be predicted best by hip adduction moment, and the second peak of HCF by hip extension moment. During running, peak HCF can be best predicted by hip adduction moment. The present study contributes hereby to a better understanding of musculoskeletal loading during walking and running in a wide range of speeds, offering valuable information to clinicians and scientists exploring bone loading as a possible nonpharmacological osteogenic stimulus. © 2015 American Society for Bone and Mineral Research. © 2015 American Society for Bone and Mineral Research.

Visual Basic 2012 programmer's reference

CERN Document Server

Stephens, Rod

2012-01-01

The comprehensive guide to Visual Basic 2012 Microsoft Visual Basic (VB) is the most popular programming language in the world, with millions of lines of code used in businesses and applications of all types and sizes. In this edition of the bestselling Wrox guide, Visual Basic expert Rod Stephens offers novice and experienced developers a comprehensive tutorial and reference to Visual Basic 2012. This latest edition introduces major changes to the Visual Studio development platform, including support for developing mobile applications that can take advantage of the Windows 8 operating system

Influence of anatomy and basic density on specific cutting force for wood from Corymbia citriodora Hill & Johnson

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Luiz-E. de L. Melo

2015-12-01

Full Text Available Aim of the study: The aim of this study was to evaluate the influence of xylem tissue cell structure, determined through biometry and basic density of the wood from Corymbia citriodora Hill & Johnson on consumption of specific 90º-0º longitudinal cutting force.Area of study: The study area was in the region of the Vale do Rio Doce - Minas Gerais, Brazil.Material and methods: A diametrical board with dimensions of 60 x 18 x 5 cm (length x width x thickness, respectively, with more than 1.3 m from the ground, was removed. In machining trials, a 400 mm diameter circular saw was used, with 24 “WZ” teeth, feed rate of 10 m.min-1, cutting speed of 61 m.s-1, and maximum instantaneous torque of 92.5 N.m. During cutting, test specimens were removed with alternated and parallel 1.5 cm edges in 6 radial positions, which were used for biometric determination of cell structure and basic density.Main results: It was observed that wood basic density, vessel diameter, fiber wall thickness, fiber wall fraction and fiber wall portion were directly proportional to the specific cutting force. In contrast, vessel frequency and fiber lumen diameter proved to be inversely proportional to cutting force.Research highlights: This work provides important values of quantification of influence of xylem tissue cell structure, determined through biometry and physical properties of the wood that may be used to prediction of consumption of specific cutting force.Keywords: wood machining; wood properties; optimization of the process.

INTRODUCTION: DESERTIFICATION AND SECURITY - PERSPECTIVES FOR THE MEDITERRANEAN REGION

Science.gov (United States)

This book focuses on two basic concepts: security and desertification in the Mediterranean Region and their linkages. It emerged from a single meeting of the "Workshop on Desertification in the Mediterranean Region. A Security Issue" held in Valencia, Spain on 2-5 December 2003...

Characteristic expression of HTLV-1 basic zipper factor (HBZ transcripts in HTLV-1 provirus-positive cells

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Yamada Yasuaki

2008-04-01

Full Text Available Abstract Background HTLV-1 causes adult T-cell leukemia (ATL. Although there have been many studies on the oncogenesis of the viral protein Tax, the precise oncogenic mechanism remains to be elucidated. Recently, a new viral factor, HTLV-1 basic Zip factor (HBZ, encoded from the minus strand mRNA was discovered and the current models of Tax-centered ATL cell pathogenesis are in conflict with this discovery. HBZs consisting of non-spliced and spliced isoforms (HBZ-SI are thought to be implicated in viral replication and T-cell proliferation but there is little evidence on the HBZ expression profile on a large scale. Results To investigate the role of HBZ-SI in HTLV-1 provirus-positive cells, the HBZ-SI and Tax mRNA loads in samples with a mixture of infected and non-infected cells were measured and then adjusted by dividing by the HTLV-I proviral load. We show here that the HBZ-SI mRNA level is 4-fold higher than non-spliced HBZ and is expressed by almost all cells harboring HTLV-1 provirus with variable intensity. The proviral-adjusted HBZ-SI and Tax quantification revealed a characteristic imbalanced expression feature of high HBZ and low Tax expression levels in primary ATL cells or high HBZ and very high Tax levels in HTLV-1-related cell lines (cell lines compared with a standard expression profile of low HBZ and low Tax in infected cells. Interestingly, according to the mutual Tax and HBZ expression status, HTLV-1-related cell lines were subcategorized into two groups, an ATL cell type with high HBZ and low Tax levels and another type with high Tax and either high or low HBZ, which was closely related to its cell origin. Conclusion This is the first comprehensive study to evaluate the mutual expression profile of HBZ and Tax in provirus-positive cells, revealing that there are quantitative and relative characteristic features among infected cells, primary ATL cells, and cell lines.

Veneto Region, Italy. Health system review.

Science.gov (United States)

Toniolo, Franco; Mantoan, Domenico; Maresso, Anna

2012-01-01

The Health Systems in Transition (HiT) profiles are country-based reports that provide a detailed description of a health system and of policy initiatives in progress or under development. This HiT is one of the first to be written on a subnational level of government and focuses on the Veneto Region of northern Italy. HiTs examine different approaches to the organization, financing and delivery of health services and the role of the main actors in health systems; describe the institutional framework, process, content and implementation of health and health care policies; and highlight challenges and areas that require more in-depth analysis. The Veneto Region is one of Italy's richest regions and the health of its resident population compares favourably with other regions in Italy. Life expectancy for both men and women, now at 79.1 and 85.2 years, respectively, is slightly higher than the national average, while mortality rates are comparable to national ones. The major causes of death are tumours and cardiovascular diseases. Under Italy's National Health Service, the organization and provision of health care is a regional responsibility and regions must provide a nationally defined (with regional input) basic health benefit package to all of their citizens; extra services may be provided if budgets allow. Health care is mainly financed by earmarked central and regional taxes, with regions receiving their allocated share of resources from the National Health Fund. Historically, health budget deficits have been a major problem in most Italian regions, but since the early 2000s the introduction of efficiency measures and tighter procedures on financial management have contributed to a significant decrease in the Veneto Regions health budget deficit.The health system is governed by the Veneto Region government (Giunta) via the Departments of Health and Social Services, which receive technical support from a single General Management Secretariat. Health care is

Back to the basic sciences: an innovative approach to teaching senior medical students how best to integrate basic science and clinical medicine.

Science.gov (United States)

Spencer, Abby L; Brosenitsch, Teresa; Levine, Arthur S; Kanter, Steven L

2008-07-01

Abraham Flexner persuaded the medical establishment of his time that teaching the sciences, from basic to clinical, should be a critical component of the medical student curriculum, thus giving rise to the "preclinical curriculum." However, students' retention of basic science material after the preclinical years is generally poor. The authors believe that revisiting the basic sciences in the fourth year can enhance understanding of clinical medicine and further students' understanding of how the two fields integrate. With this in mind, a return to the basic sciences during the fourth year of medical school may be highly beneficial. The purpose of this article is to (1) discuss efforts to integrate basic science into the clinical years of medical student education throughout the United States and Canada, and (2) describe the highly developed fourth-year basic science integration program at the University of Pittsburgh School of Medicine. In their critical review of medical school curricula of 126 U.S. and 17 Canadian medical schools, the authors found that only 19% of U.S. medical schools and 24% of Canadian medical schools require basic science courses or experiences during the clinical years, a minor increase compared with 1985. Curricular methods ranged from simple lectures to integrated case studies with hands-on laboratory experience. The authors hope to advance the national discussion about the need to more fully integrate basic science teaching throughout all four years of the medical student curriculum by placing a curricular innovation in the context of similar efforts by other U.S. and Canadian medical schools.

Uptake of acidic and basic sugar derivatives in Lemna gibba G1

International Nuclear Information System (INIS)

Sanz, A.; Ullrich, C.I.

1989-01-01

The uptake of acidic and basic sugar derivatives in Lemna gibba L. was studied. Uronic acids applied to the experimental solution induced a small decrease of the membrane potential. After incubation of the plants in a 0.1 millimolar solution of these substrates, no decrease in the concentration of reducing groups in the external solution was detected. Respiration increased by 31% with 50 millimolar galacturonic acid, whereas no effect was found with the same concentration of glucuronic acid. Glucosamine caused a considerable concentration-dependent membrane depolarization. ( 14 C)glucosamine uptake followed Michaelis-Menten kinetics together with a linear component. Influx of this substrate was inhibited by glucose but the type of competition could not be clearly distinguished. Glucosamine, 50 millimolar, inhibited the respiration rate by 30%. The glucosamine uptake was pH-dependent, with maximum uptake at around pH 7. Lack of enhancement of uptake by low pH as well as the permanent membrane depolarization suggest a uniport mechanism for the charged species of the substrate and an electroneutral diffusion of the uncharged species

Techno-economic assessment of an off-grid PV system for developing regions to provide electricity for basic domestic needs: A 2020–2040 scenario

International Nuclear Information System (INIS)

Zubi, Ghassan; Dufo-López, Rodolfo; Pasaoglu, Guzay; Pardo, Nicolás

2016-01-01

Highlights: • Off-grid PV has a huge potential to provide effective solutions for energy poverty. • Its implementation barrier is economic, but paths to effectively tackle this exist. • The implementation barriers will be reduced by a favourable technological evolution. • Cost reductions to the level of grid-connected power will be eventually achieved. - Abstract: While in the developed countries electrification is paving the way for progress and prosperity, nowadays electricity is still not accessible for about 18% of the world’s population. Lack of power grids is the main reason that prevents millions in remote areas in developing countries from using electricity for the daily basic needs. PV systems provide an effective solution for these regions, but affordability remains an issue. This barrier can be widely overcome on the short term by limiting PV power supply to very high added value applications and by properly exploiting innovations, especially in energy efficiency and cost reductions. Additional to that, the long-term perspectives of off-grid PV are very favourable based on its ongoing technological improvements and cost reductions. This paper studies four off-grid PV cases of which each could cover a combination of basic energy needs regarding light, cooking, food conservation and electronic appliances. Case I considers a system that supplies power for LED lamps and electronic devices. Accordingly, Case II adds a fridge and Case III an electric rice cooker to Case I, while Case IV adds both. The paper elaborates on available technologies and future developments regarding all components in order to assess the long term evolution and potential of these applications, most specifically how their affordability would evolve over time. The modelling and optimization of the four cases are performed using the software iHOGA, which is an efficient tool to provide the lowest cost solution for off-grid PV systems. The use of iHOGA for the four cases and

[Complex regional pain syndrome type 1: negating the myth

NARCIS (Netherlands)

Frolke, J.P.M.; Dongen, R.T.M. van; Meent, H. van de

2015-01-01

Complex regional pain syndrome type 1 (CRPS-1) was identified in the Netherlands more than 30 years ago, but since then the arguments supporting this diagnosis have become weaker. Incidence has decreased, it is often not possible to make a definite diagnosis, the pathophysiology remains unclear and

How to interpret an unenhanced CT Brain scan. Part 1: Basic principles of Computed Tomography and relevant neuroanatomy

Directory of Open Access Journals (Sweden)

Thomas Osborne

2016-08-01

Full Text Available The aim of this article is to: Cover the basics of Computed Tomography (CT Brain imaging. Review relevant CT neuroanatomy. A CT image is produced by firing x-rays at a moving object which is then detected by an array of rotating detectors (Figure 1. The detected x-rays are then converted into a computerised signal which is used to produce a series of cross sectional images.

Setting Up Workplace Basic Skills Training. Guidelines for Practitioners. An ALBSU Special Development Project.

Science.gov (United States)

Rees, Libby

This guide provides information on basic skills needs and programs in the workplace and issues affecting basic skills provision from a British perspective. Section 1 aims to provide a context for workplace basic skills provision. Sections 2-7 provide practical suggestions and advice on the following topics: (1) marketing; (2) contacting employers;…

Axial variation of basic density of Araucaria angustifolia wood in different diameter classes

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Rômulo Trevisan

Full Text Available ABSTRACT: The study of the wood characteristics is of fundamental importance for the correct use of this raw material and, among its properties, the basic density is a major, being reference in the quality of this material. This study aimed to evaluate the axial variation of basic density of the wood of Araucaria angustifolia (Bertoloni O. Kuntze in different diameter classes. For this, three trees were selected in six diameter classes, called class 1 (20-30cm, class 2 (30.1-40cm, class 3 (40.1-50cm, class 4 (50.1-60cm, class 5 (60.1-70cm and class 6 (70.1-80cm. From each individual sampled was withdrawn a disc at 0.1m (base, 25, 50, 75 and 100% of the height of the first live branch and in the diameter at 1.30m from the ground (DBH, which were used for determining basic density. The weighted average basic density was equal to 0.422g cm-3 and, regardless of the diameter class analyzed, this property decreased in the axial direction. Diameter induced variation of basic density, but has not been verified a positive or negative systematic tendency in relation to the sampled interval.

Mineralogical and structural transformations related to alterations in hydrothermal and climatological conditions of basic vulcanic rocks from northern Parana (Ribeirao Preto region, SP, Brazil)

International Nuclear Information System (INIS)

Goncalves, N.M.M.

1987-01-01

Detailed studies of the basic vulcanic rocks of northern Parana basin (Region of Ribeirao Preto, SP) reveled that these rocks were affected by pre-meteoric activity (hydrothermal alteration) before being exposed to the supergene system of alteration linked to the lithosphere/atmosphere interface. Mineralogical and structural transformation are studied. The appearance of sequential crystalline-chemical paragenesis in zones suggest that the hydrothermal activity occurred during two successives processes of alteration: the expulsion of the water from the rock during the later stages of magma cooling and the continous process of dissolution of the rock wall and the ionic diffusion involving the rock sistem of structural voids. The hydro-thermal action was followed by weathering action developing a thin 'front' of superficial alteration. This alteration system, can lead to the formation of three major levels of alteration horizons and superficial accumulations: alterites, glebular and suil surface materials. (C.D.G.) [pt

Northeastern Regional environmental characterization report. Volume 1. Final report

International Nuclear Information System (INIS)

1985-08-01

This report presents available environmental information pertinent to siting a repository for high-level nuclear waste in crystalline rock in Maine, New Hampshire, Vermont, northeastern and southeastern New York, Massachusetts, Rhode Island, Connecticut, northern New Jersey, and eastern Pennsylvania. For each of the States within the Northeastern Region, information is provided on those environmental disqualifying factors and regional screening variables to be used in region-to-area screening. These environmental factors and variables include existing and proposed Federal-protected lands, components of National Forest Lands, proximity to Federal-protected lands, existing State-protected lands, proximity to State-protected lands, population density and distribution, proximity to highly populated areas, or to 1-mile-square areas with 1000 or more persons, National and State forest lands, designated critical habitats for threatened and endangered species, surface water bodies, and wetlands. In addition, supplementary descriptive information providing a general characterization of the region is presented, as is information on environmental parameters that will be of use at later phases of screening. Also included is a discussion of the relationship between the US Department of Energy Siting Guidelines (10 CFR 960) and those environmental disqualifying factors and regional screening variables to be used in the region-to-area screening process

EPA Region 1 - Valley Depth in Meters

Science.gov (United States)

Raster of the Depth in meters of EPA-delimited Valleys in Region 1.Valleys (areas that are lower than their neighbors) were extracted from a Digital Elevation Model (USGS, 30m) by finding the local average elevation, subtracting the actual elevation from the average, and selecting areas where the actual elevation was below the average. The landscape was sampled at seven scales (circles of 1, 2, 4, 7, 11, 16, and 22 km radius) to take into account the diversity of valley shapes and sizes. Areas selected in at least four scales were designated as valleys.

A role for topographic cues in the organization of collagenous matrix by corneal fibroblasts and stem cells.

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Dimitrios Karamichos

Full Text Available Human corneal fibroblasts (HCF and corneal stromal stem cells (CSSC each secrete and organize a thick stroma-like extracellular matrix in response to different substrata, but neither cell type organizes matrix on tissue-culture polystyrene. This study compared cell differentiation and extracellular matrix secreted by these two cell types when they were cultured on identical substrata, polycarbonate Transwell filters. After 4 weeks in culture, both cell types upregulated expression of genes marking differentiated keratocytes (KERA, CHST6, AQP1, B3GNT7. Absolute expression levels of these genes and secretion of keratan sulfate proteoglycans were significantly greater in CSSC than HCF. Both cultures produced extensive extracellular matrix of aligned collagen fibrils types I and V, exhibiting cornea-like lamellar structure. Unlike HCF, CSSC produced little matrix in the presence of serum. Construct thickness and collagen organization was enhanced by TGF-ß3. Scanning electron microscopic examination of the polycarbonate membrane revealed shallow parallel grooves with spacing of 200-300 nm, similar to the topography of aligned nanofiber substratum which we previously showed to induce matrix organization by CSSC. These results demonstrate that both corneal fibroblasts and stromal stem cells respond to a specific pattern of topographical cues by secreting highly organized extracellular matrix typical of corneal stroma. The data also suggest that the potential for matrix secretion and organization may not be directly related to the expression of molecular markers used to identify differentiated keratocytes.

42 CFR 422.352 - Basic requirements.

Science.gov (United States)

2010-10-01

...) MEDICARE PROGRAM MEDICARE ADVANTAGE PROGRAM Provider-Sponsored Organizations § 422.352 Basic requirements... effectively controlled by the provider or, in the case of a group, by one or more of the affiliated providers... provider or the affiliated providers responsible for operating the PSO. Substantial proportion means— (1...

14 CFR 31.85 - Required basic equipment.

Science.gov (United States)

2010-01-01

... following equipment is required: (a) For all balloons: (1) [Reserved] (2) An altimeter. (3) A rate of climb indicator. (b) For hot air balloons: (1) A fuel quantity gauge. If fuel cells are used, means must be... AIRWORTHINESS STANDARDS: MANNED FREE BALLOONS Operating Limitations and Information § 31.85 Required basic...

Conceptual design of the hot cell facility universal docking station at ITER

International Nuclear Information System (INIS)

Dammann, A.; Benchikhoune, M.; Friconneau, J.P.; Ivanov, V.; Lemee, A.; Martins, J.P.; Tamassy, G.

2011-01-01

Between main shutdowns of the ITER machine, in-vessel components and Iter Remote Maintenance System (IRMS) are transferred between the Tokamak complex and the Hot Cell Facility using different types of sealed casks. Transfer Casks have different physical interfaces with the Vacuum Vessel, which need to be the same at the docking stations of the HCF. It means that in-vessel components and IRMS are cleaned in the same cells, which is in fact not convenient. Furthermore, logistic studies showed that the use rate of the cells is very inhomogeneous. In order to have dedicated cell for decontamination of Remote Handling tools, in order to increase the operability efficiency and to removes the hot cell docking operation from the critical path, the concept of a universal docking station has been investigated. Based on an existing design, the work was focused on a review of requirements, the re-design and the integration within the HCF layout. The universal docking station has been proposed and is now integrated in HCF design.

Conceptual design of the hot cell facility universal docking station at ITER

Energy Technology Data Exchange (ETDEWEB)

Dammann, A., E-mail: alexis.dammann@iter.org [ITER Organization, CS 90 046, 13067 St Paul Lez Durance Cedex (France); Benchikhoune, M.; Friconneau, J.P.; Ivanov, V. [ITER Organization, CS 90 046, 13067 St Paul Lez Durance Cedex (France); Lemee, A. [SOGETI High Tech, 180 Rue Rene Descartes, 13851 Aix en Provence (France); Martins, J.P. [ITER Organization, CS 90 046, 13067 St Paul Lez Durance Cedex (France); Tamassy, G. [SOGETI High Tech, 180 Rue Rene Descartes, 13851 Aix en Provence (France)

2011-10-15

Between main shutdowns of the ITER machine, in-vessel components and Iter Remote Maintenance System (IRMS) are transferred between the Tokamak complex and the Hot Cell Facility using different types of sealed casks. Transfer Casks have different physical interfaces with the Vacuum Vessel, which need to be the same at the docking stations of the HCF. It means that in-vessel components and IRMS are cleaned in the same cells, which is in fact not convenient. Furthermore, logistic studies showed that the use rate of the cells is very inhomogeneous. In order to have dedicated cell for decontamination of Remote Handling tools, in order to increase the operability efficiency and to removes the hot cell docking operation from the critical path, the concept of a universal docking station has been investigated. Based on an existing design, the work was focused on a review of requirements, the re-design and the integration within the HCF layout. The universal docking station has been proposed and is now integrated in HCF design.

Weathering products of basic rocks as sorptive materials of natural radionuclides

International Nuclear Information System (INIS)

Omelianenko, B.I.; Niconov, B.S.; Ryzhov, B.I.; Shikina, N.D.

1994-06-01

The principal requirements for employing natural minerals as buffer and backfill material in high-level waste (HLW) repositories are high sorptive properties, low water permeability, relatively high thermal conductivity, and thermostability. The major task of the buffer is to prevent the penetration of radionuclides into groundwater. The authors of this report examined weathered basic rocks from three regions of Russia in consideration as a suitable radioactive waste barrier

Compensation of Emergency Medical Technician (EMT)-Basics and Paramedics.

Science.gov (United States)

Studnek, Jonathan R

2016-12-01

The objective of this paper is to identify factors associated with compensation for Emergency Medical Technician (EMT)-Basics and Paramedics and assess whether these associations have changed over the period 1999-2008. Data obtained from the Longitudinal EMT Attributes and Demographic Study (LEADS) surveys, a mail survey of a random, stratified sample of nationally certified EMT-Basics and Paramedics, were analyzed. For the 1999-2003 period, analyses included all respondents providing Emergency Medical Services (EMS). With the addition of a survey in 2004 about volunteers, it was possible to exclude volunteers from these analyses. Over 60% of EMT-Basics reported being either compensated or noncompensated volunteers in the 2004-2008 period. This was substantially and significantly greater than the proportion of EMT-Paramedic volunteers (Technician (EMT)-Basics and Paramedics. Prehosp Disaster Med. 2016;31(Suppl. 1):s87-s95.

Cross-Regional Differences in Meeting the Challenge of Teacher Salary Increase

Science.gov (United States)

Derkachev, P. V.

2015-01-01

This paper presents an overview of studies on the correlations of teacher pay to regional economics and to regional factors affecting the size of teacher salaries. It describes the basic pay indicators for teachers in the regions: absolute salary, teacher pay level as compared to the average regional salary, and ratio of salary to the cost of a…

The basic features of clay rock in Tamusu area

International Nuclear Information System (INIS)

Liu Xiaodong; Liu Pinghui

2012-01-01

This paper introduces the Tamusu area location, natural and social economic situation, the regional geological background, as well as the upper Gobi formation of clay rocks, and from the geological conditions, economic conditions, social conditions and other aspects of the Tamusu claystone conducted a preliminary evaluation. The results showed that this area can be used as one of the favorable preselected areas for high-level radioactive waste geological disposal repository, basically meets the siting criteria for geological conditions, environmental protection, land use, social influence and waste transport etc. (authors)

Ways to develop the prophylaxis of post-transfusion hemolytic complications

Directory of Open Access Journals (Sweden)

B. B. Bahovadinov

2015-01-01

Full Text Available Post-transfusion hemolytic complications (РНС remain аn urgent рrоblem in medical practice despite the improvement of selecting methods of compatible blood transfusion for patients. The numbеr of РНС remains still high (1 in 6 000 - 29 000 transfusions. Aim: to analyze cases of РНС registered in health care facilities (HCF in the Republic of Tajikistan. Method of investigation. Retrospective analysis of materials of national аnd regional committees оп investigation of РНС cases, histories fro hospital archives. During the period 1989-2014 in health facilities were registered 86 cases of РНС approximately 850 000 doses of red bооd cell transfusions containing blооd components, or 1 in 9418 doses of red blood cell-containing blood components. РНС reasons were: incompatibility of АВО blооd group system - 32 (37,3 %, antigen D of blооd group Rhesus factor system - 34 (39,53 %, according to minor blood group antigens of Rhesus factor and Kell blood group system (С, с, Е, е, К - 16 (18,6 %. In 4 cases (4,6 % the cases of РНС were hemolytic transfusions of erythrocyte-containing bags as а result of improper storage in domestic refrigeration without control of temperature storage. Causes of development 78 out of 86 РНС (90,69 % were HCF doctors' mistakes, 8 (9,31 % - mistakes of health personnel of health facilities departments of blood transfusion аnd regional blооd centers. Reducing the frequency of PHC is impossible without training physicians оn transfusion medicine, introduction of modern methods of phenotyping erythrocyte antigens of recipients and donors оn major transfusion significant blood group antigens the АВО system by direct and cross-over methods, Rhesus (С, с, Е, е, Kell (К of patients requiring multiple transfusions, as well as to girls and women of childbearing age.

Patient perspectives on the promptness and quality of care of road traffic incident victims in Peru: a cross-sectional, active surveillance study

Science.gov (United States)

Miranda, J Jaime

2013-01-01

Background: Road injuries are the second-leading cause of disease and injury in the Andean region of South America. Adequate management of road traffic crash victims is important to prevent and reduce deaths and serious long-term injuries. Objective: To evaluate the promptness of health care services provided to those injured in road traffic incidents (RTIs) and the satisfaction with those services during the pre-hospital and hospital periods. Methods: We conducted a cross-sectional study with active surveillance to recruit participants in emergency departments at eight health care facilities in three Peruvian cities: a large metropolitan city (Lima) and two provincial cities (an urban center in the southern Andes and an urban center in the rainforest region), between August and September 2009. The main outcomes of interest were promptness of care, measured by time between injury and each service offered, as well as patient satisfaction measured by the Service Quality (SERVQUAL) survey. We explored the association between outcomes and city, type of health care facility (HCF), and type of provider. Results: We recruited 644 adults seeking care for RTIs. This active surveillance strategy yielded 34% more events than anticipated, suggesting under-reporting in traditional registries. Median response time between a RTI and any care at a HCF was 33 minutes overall and only 62% of participants received professional care during the initial “golden” hour after the RTI. After adjustment for various factors, there was strong evidence of higher global dissatisfaction levels among those receiving care at public HCFs compared to private ones (odds ratio (OR) 5.05, 95% confidence interval (CI) 1.88-13.54). This difference was not observed when provincial sites were compared to Lima (OR 1.41, 95% CI 0.42-4.70). Conclusions: Response time to RTIs was adequate overall, though a large proportion of RTI victims could have received more prompt care. Overall, dissatisfaction was

Basic design of the beam diagnostic device and proposal of a new electrostatic optical element

Energy Technology Data Exchange (ETDEWEB)

Hanashima, Susumu [Japan Atomic Energy Research Inst., Tokyo (Japan)

2001-02-01

The basic design completed of a beam diagnostic device, which indicates, among others, the phase space regions acceptable by the beams, and density distributions in the phase space as well. The measurement is made using two deflectors and two apertures. (M. Tanaka)

Inflation Basics

International Nuclear Information System (INIS)

Green, Dan

2014-01-01

The last few years have yielded remarkable discoveries in physics. In particle physics it appears that a fundamental scalar field exists. The Higgs boson is measured to have a mass of about 126 GeV and to have spin zero and positive parity. The Higgs field is the first fundamental scalar to be discovered in physics. The Cosmic Microwave Background, CMB, is known to have a uniform temperature to parts per 10 5 , but has well measured fluctuations, which are thought to evolve gravitationally to provide the seeds of the current structure of the Universe. In addition, the Universe appears to contain, at present, an unknown ''dark energy'', which is presently the majority energy density of the Universe, larger than either matter or radiation. This may, indeed, be a fundamental scalar field like the Higgs. ''Big Bang'' (BB) cosmology is a very successful ''standard model'' in cosmology. However, it cannot explain the uniformity of the CMB because the CMB consists of many regions not causally connected in the context of the BB model. In addition, the Universe appears to be spatially flat. However, in BB cosmology the present spatial curvature is not stable, so that the initial conditions for BB cosmology would need to be fantastically fine-tuned in order to successfully predict the presently small value of the observed curvature. These issues for BB cosmology have led to the hypothesis of ''inflation'' which postulates an unknown scalar field, not presumably the Higgs field or the dark energy, which causes an exponential expansion of the Universe at very early times. This attractive hypothesis can account for the problems in BB cosmology of flatness and causal CMB connectivity. In addition, the quantum fluctuations of this postulated field provide a natural explanation of the CMB fluctuations which are the seeds of the structure of galaxies. Researchers are now searching for gravitational

Inflation Basics

Energy Technology Data Exchange (ETDEWEB)

Green, Dan [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States)

2014-03-01

The last few years have yielded remarkable discoveries in physics. In particle physics it appears that a fundamental scalar field exists. The Higgs boson is measured to have a mass of about 126 GeV and to have spin zero and positive parity. The Higgs field is the first fundamental scalar to be discovered in physics. The Cosmic Microwave Background, CMB, is known to have a uniform temperature to parts per 10⁵, but has well measured fluctuations, which are thought to evolve gravitationally to provide the seeds of the current structure of the Universe. In addition, the Universe appears to contain, at present, an unknown “dark energy”, which is presently the majority energy density of the Universe, larger than either matter or radiation. This may, indeed, be a fundamental scalar field like the Higgs. “Big Bang” (BB) cosmology is a very successful “standard model” in cosmology. However, it cannot explain the uniformity of the CMB because the CMB consists of many regions not causally connected in the context of the BB model. In addition, the Universe appears to be spatially flat. However, in BB cosmology the present spatial curvature is not stable, so that the initial conditions for BB cosmology would need to be fantastically fine-tuned in order to successfully predict the presently small value of the observed curvature. These issues for BB cosmology have led to the hypothesis of “inflation” which postulates an unknown scalar field, not presumably the Higgs field or the dark energy, which causes an exponential expansion of the Universe at very early times. This attractive hypothesis can account for the problems in BB cosmology of flatness and causal CMB connectivity. In addition, the quantum fluctuations of this postulated field provide a natural explanation of the CMB fluctuations which are the seeds of the structure of galaxies. Researchers are now searching for gravitational waves imprinted on the CMB. These would be a “smoking gun” for

ESSENCE, STRUCTURE AND FUNCTIONS OF THE REGIONAL FINANCIAL SYSTEM

Directory of Open Access Journals (Sweden)

A. V. Milenkov

2015-01-01

Full Text Available The scientific themes of the article is relevant, as in the domestic and foreign economic literature, the term "financial system" does not comply with the fundamental theory of systems in which the system views revealed as a set of interrelated and interacting elements in accordance with the set to achieve the goal. Each of the elements of multi-level financial system has its own organizational structure, consisting of institutions and organizations within the jurisdiction of the entity government. In the article the author's interpretation of the concepts of "institutional framework," "organizational structure" of the regional financial system, defined the task of the financial system was to create rules and regulations of its operation, set out the basic functions of the institutions and organizations of the regional financial system, analyzes the external communication of the financial system, the implementation of which is one of the basic conditions for the effective functioning of the financial system in the region due to its inclusion in the federal and international financial sector. The contribution of the author in the development of the theme of the article is to specify and clarify the concepts of "the financial system", "institutional and organizational structure of the regional financial system," the development of methodological approaches to the formulation and use of methods of solving the institutional and organizational problems of the financial system in the region, the rationalization of the rules and regulations it current operation and future development, the definition of the composition of the basic functions that are adequate specialization and features of the institutes and organizations of the regional financial system.

Comprehensive basic mathematics

CERN Document Server

Veena, GR

2005-01-01

Salient Features As per II PUC Basic Mathematics syllabus of Karnataka. Provides an introduction to various basic mathematical techniques and the situations where these could be usefully employed. The language is simple and the material is self-explanatory with a large number of illustrations. Assists the reader in gaining proficiency to solve diverse variety of problems. A special capsule containing a gist and list of formulae titled ''REMEMBER! Additional chapterwise arranged question bank and 3 model papers in a separate section---''EXAMINATION CORNER''.

Phactr3/scapinin, a member of protein phosphatase 1 and actin regulator (phactr family, interacts with the plasma membrane via basic and hydrophobic residues in the N-terminus.

Directory of Open Access Journals (Sweden)

Akihiro Itoh

Full Text Available Proteins that belong to the protein phosphatase 1 and actin regulator (phactr family are involved in cell motility and morphogenesis. However, the mechanisms that regulate the actin cytoskeleton are poorly understood. We have previously shown that phactr3, also known as scapinin, localizes to the plasma membrane, including lamellipodia and membrane ruffles. In the present study, experiments using deletion and point mutants showed that the basic and hydrophobic residues in the N-terminus play crucial roles in the localization to the plasma membrane. A BH analysis (http://helixweb.nih.gov/bhsearch is a program developed to identify membrane-binding domains that comprise basic and hydrophobic residues in membrane proteins. We applied this program to phactr3. The results of the BH plot analysis agreed with the experimentally determined region that is responsible for the localization of phactr3 to the plasma membrane. In vitro experiments showed that the N-terminal itself binds to liposomes and acidic phospholipids. In addition, we showed that the interaction with the plasma membrane via the N-terminal membrane-binding sequence is required for phactr3-induced morphological changes in Cos7 cells. The membrane-binding sequence in the N-terminus is highly conserved in all members of the phactr family. Our findings may provide a molecular basis for understanding the mechanisms that allow phactr proteins to regulate cell morphogenesis.

Regionalization of Drought across South Korea Using Multivariate Methods

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Muhammad Azam

2017-12-01

Full Text Available Topographic and hydro-climatic features of South Korea are highly heterogeneous and able to influence the drought phenomena in the region. The complex topographical and hydro-climatic features of South Korea need a statistically accurate method to find homogeneous regions. Regionalization of drought in a bivariate framework has scarcely been applied in South Korea before. Hierarchical Classification on Principal Components (HCPC algorithm together with Principal Component Analysis (PCA method and cluster validation indices were investigated and used for the regionalization of drought across the South Korean region. Statistical homogeneity and discordancy of the region was tested on univariate and bivariate frameworks. HCPC indicate that South Korea should be divided into four regions which are closer to being homogeneous. Univariate and bivariate homogeneity and discordancy tests showed the significant difference in their results due to the inability of univariate homogeneity and discordancy measures to consider the joint behavior of duration and severity. Regionalization of drought for SPI time scale of 1, 3, 6, 12, and 24 months showed significant variation in discordancy and homogeneity of the region with the change in SPI time scale. The results of this study can be used as basic data required to establish a drought mitigation plan on regional scales.

Influence of Casting Defects on S- N Fatigue Behavior of Ni-Al Bronze

Science.gov (United States)

Sarkar, Aritra; Chakrabarti, Abhishek; Nagesha, A.; Saravanan, T.; Arunmuthu, K.; Sandhya, R.; Philip, John; Mathew, M. D.; Jayakumar, T.

2015-02-01

Nickel-aluminum bronze (NAB) alloys have been used extensively in marine applications such as propellers, couplings, pump casings, and pump impellers due to their good mechanical properties such as tensile strength, creep resistance, and corrosion resistance. However, there have been several instances of in-service failure of the alloy due to high cycle fatigue (HCF). The present paper aims at characterizing the casting defects in this alloy through X-ray radiography and X-ray computed tomography into distinct defect groups having particular defect size and location. HCF tests were carried out on each defect group of as-cast NAB at room temperature by varying the mean stress. A significant decrease in the HCF life was observed with an increase in the tensile mean stress, irrespective of the defect size. Further, a considerable drop in the HCF life was observed with an increase in the size of defects and proximity of the defects to the surface. However, the surface proximity indicated by location of the defect in the sample was seen to override the influence of defect size and maximum cyclic stress. This leads to huge scatter in S- N curve. For a detailed quantitative analysis of defect size and location, an empirical model is developed which was able to minimize the scatter to a significant extent. Further, a concept of critical distance is proposed, beyond which the defect would not have a deleterious consequence on the fatigue behavior. Such an approach was found to be suitable for generating S- N curves for cast NAB.

Safety research basic plan of JNC

Energy Technology Data Exchange (ETDEWEB)

NONE

1999-03-01

Japan Nuclear Cycle Development Institute (JNC) formally succeeded to Power Reactor and Nuclear Fuel Development Corporation (PNC) on October, 1 1998. This report describes the basic plan for major program of JNC which consists of two parts: management philosophy of the new institute and the latest revised medium term program. In the first part, the primary mission of JNC is to perform its R and D concentrating on fast breeder reactor and its fuel cycle, and treatment and disposal of high-level radioactive wastes, while at the same time giving special consideration to safety. In the second, individual programs in the new basic plan are discussed in detail. The outline and schedule of each program are also attached in the table form. (H. Itami)

Energy options and regional cooperation on nuclear energy in the Asia-Pacific region

International Nuclear Information System (INIS)

Shin, Jae In

1986-10-01

This paper reviews the extensive forms of Asia-Pacific regional cooperation in nuclear power to develop and provide economical and reliable energy supply for sound economical growths of developing countries in this region, which has seen rapid growth of energy consumption more than anywhere else in recent years. Nuclear power has received keen attention from DCs because it can provide a self-reliable energy supply and promote development of high technology in the associated engineering and manufacturing industries locally. However, due to the particular characteristics in nuclear power technology, a close cooperation is required between the seller(industrialized) and buyer(developing) countries. The Asia-Pacific regional cooperation in nuclear power is a step toward providing mutual benefits to the countries involved in this region, and this paper explores potential ways in formulating basic and systematic approaches and areas of full scope cooperation. (author)

Geoengineering: Basic science and ongoing research efforts in China

Directory of Open Access Journals (Sweden)

Long Cao

2015-09-01

Full Text Available Geoengineering (also called climate engineering, which refers to large-scale intervention in the Earth's climate system to counteract greenhouse gas-induced warming, has been one of the most rapidly growing areas of climate research as a potential option for tackling global warming. Here, we provide an overview of the scientific background and research progress of proposed geoengineering schemes. Geoengineering can be broadly divided into two categories: solar geoengineering (also called solar radiation management, or SRM, which aims to reflect more sunlight to space, and carbon dioxide removal (CDR, which aims to reduce the CO2 content in the atmosphere. First, we review different proposed geoengineering methods involved in the solar radiation management and carbon dioxide removal schemes. Then, we discuss the fundamental science underlying the climate response to the carbon dioxide removal and solar radiation management schemes. We focus on two basic issues: 1 climate response to the reduction in solar irradiance and 2 climate response to the reduction in atmospheric CO2. Next, we introduce an ongoing geoengineering research project in China that is supported by National Key Basic Research Program. This research project, being the first coordinated geoengineering research program in China, will systematically investigate the physical mechanisms, climate impacts, and risk and governance of a few targeted geoengineering schemes. It is expected that this research program will help us gain a deep understanding of the physical science underlying geoengineering schemes and the impacts of geoengineering on global climate, in particular, on the Asia monsoon region.

Safety Training: Basic Safety and Access Courses

CERN Multimedia

Antonella Vignes

2005-01-01

Objective The purpose of the basic safety courses is to increase awareness for everyone working on the CERN site (CERN staff, associates, outside companies, students and apprentices) of the various existing on-site hazards, and how to recognize and avoid them. Safety course changes The current organization for basic safety courses is changing. There will be two main modifications: the organization of the courses and the implementation of a specific new training course for the LHC machine during the LHC tests and hardware commissioning phase. Organizational changes This concerns the existing basic safety training, currently called level1, level2 and level3. Under the new procedure, a video will be projected in registration building 55 and will run every day at 14.00 and 15.00 in English. The duration of the video will be 50 minutes. The course contents will be the same as the slides currently used, plus a video showing real situations. With this new organization, attendees will systematically follow the...

Safety Training: basic safety and access courses

CERN Multimedia

2005-01-01

Objective The purpose of the basic safety courses is to increase awareness for everyone working on the CERN site (CERN staff, associates, outside companies, students and apprentices) of the various hazards existing on site, and how to recognise and avoid them. Safety course changes The current organisation of basic safety courses is changing. There will be two main modifications: the organisation of the courses and the implementation of a specific new training course for the LHC machine during the LHC tests and hardware commissioning phase. Organisational changes This concerns the existing basic safety training, currently called level 1, level 2 and level 3. Under the new procedure, a video will be projected in registration building 55 and will run every day at 14.00 and 15.00 in English. The duration of the video will be 50 minutes. The course contents will be the same as the slides currently used, plus a video showing real situations. With this new organization, participants will systematically follow...

Wind Energy Basics | NREL

Science.gov (United States)

Wind Energy Basics Wind Energy Basics We have been harnessing the wind's energy for hundreds of grinding grain. Today, the windmill's modern equivalent-a wind turbine can use the wind's energy to most energy. At 100 feet (30 meters) or more aboveground, they can take advantage of the faster and

Biomass Energy Basics | NREL

Science.gov (United States)

Biomass Energy Basics Biomass Energy Basics We have used biomass energy, or "bioenergy" keep warm. Wood is still the largest biomass energy resource today, but other sources of biomass can landfills (which are methane, the main component in natural gas) can be used as a biomass energy source. A

Preparation, characterization and electrocatalytic behavior of zinc oxide/zinchexacyanoferrate and ruthenium oxide hexacyanoferrate hybrid film-modified electrodes

Energy Technology Data Exchange (ETDEWEB)

Chu, H.-W.; Thangamuthu, R. [Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, No. 1, Section 3, Chung-Hsiao East Road, Taipei 106, Taiwan (China); Chen, S.-M. [Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, No. 1, Section 3, Chung-Hsiao East Road, Taipei 106, Taiwan (China)], E-mail: smchen78@ms15.hinet.net

2008-02-15

Polynuclear mixed-valent hybrid films of zinc oxide/zinchexacyanoferrate and ruthenium oxide hexacyanoferrate (ZnO/ZnHCF-RuOHCF) have been deposited on electrode surfaces from H{sub 2}SO{sub 4} solution containing Zn(NO{sub 3}){sub 2}, RuCl{sub 3} and K{sub 3}[Fe(CN){sub 6}] by potentiodynamic cycling method. Simultaneous cyclic voltammetry and electrochemical quartz crystal microbalance (EQCM) measurements demonstrate the steady growth of hybrid film. Surface morphology of hybrid film was investigated using scanning electron microscopy (SEM). Energy dispersive spectrometer (EDS) data confirm existence of zinc oxide and ruthenium oxide hexacyanoferrate (RuOHCF) in the hybrid film. The effect of type of monovalent cations on the redox behavior of hybrid film was investigated. In pure supporting electrolyte, electrochemical responses of Ru{sup II/III} redox transition occurring at negative potential region resemble with that of a surface immobilized redox couple. The electrocatalytic activity of ZnO/ZnHCF-RuOHCF hybrid film was investigated towards oxidation of epinephrine, dopamine and L-cysteine, and reduction of S{sub 2}O{sub 8}{sup 2-} and SO{sub 5}{sup 2-} as well as IO{sub 3}{sup -} using cyclic voltammetry and rotating ring disc electrode (RRDE) techniques.

Introduction to Pharmaceutical Biotechnology, Volume 1; Basic techniques and concepts

Science.gov (United States)

Bhatia, Saurabh; Goli, Divakar

2018-05-01

Animal biotechnology is a broad field including polarities of fundamental and applied research, as well as DNA science, covering key topics of DNA studies and its recent applications. In Introduction to Pharmaceutical Biotechnology, DNA isolation procedures followed by molecular markers and screening methods of the genomic library are explained. Interesting areas like isolation, sequencing and synthesis of genes, with the broader coverage on synthesis of genes, are also described. The book begins with an introduction to biotechnology and its main branches, explaining both the basic science and the applications of biotechnology-derived pharmaceuticals, with special emphasis on their clinical use. It then moves on to historical development and scope of biotechnology with an overall review of early applications that scientists employed long before the field was defined.

Rapid Deterioration of Basic Life Support Skills in Dentists With Basic Life Support Healthcare Provider.

Science.gov (United States)

Nogami, Kentaro; Taniguchi, Shogo; Ichiyama, Tomoko

2016-01-01

The aim of this study was to investigate the correlation between basic life support skills in dentists who had completed the American Heart Association's Basic Life Support (BLS) Healthcare Provider qualification and time since course completion. Thirty-six dentists who had completed the 2005 BLS Healthcare Provider course participated in the study. We asked participants to perform 2 cycles of cardiopulmonary resuscitation on a mannequin and evaluated basic life support skills. Dentists who had previously completed the BLS Healthcare Provider course displayed both prolonged reaction times, and the quality of their basic life support skills deteriorated rapidly. There were no correlations between basic life support skills and time since course completion. Our results suggest that basic life support skills deteriorate rapidly for dentists who have completed the BLS Healthcare Provider. Newer guidelines stressing chest compressions over ventilation may help improve performance over time, allowing better cardiopulmonary resuscitation in dental office emergencies. Moreover, it may be effective to provide a more specialized version of the life support course to train the dentists, stressing issues that may be more likely to occur in the dental office.

Basic RNases of wild almond (Prunus webbii): cloning and characterization of six new S-RNase and one "non-S RNase" genes.

Science.gov (United States)

Banović, Bojana; Surbanovski, Nada; Konstantinović, Miroslav; Maksimović, Vesna

2009-03-01

In order to investigate the S-RNase allele structure of a Prunus webbii population from the Montenegrin region of the Balkans, we analyzed 10 Prunus webbii accessions. We detected 10 different S-RNase allelic variants and obtained the nucleotide sequences for six S-RNases. The BLAST analysis showed that these six sequences were new Prunus webbii S-RNase alleles. It also revealed that one of sequenced alleles, S(9)-RNase, coded for an amino acid sequence identical to that for Prunus dulcis S(14)-RNase, except for a single conservative amino acid replacement in the signal peptide region. Another, S(3)-RNase, was shown to differ by only three amino acid residues from Prunus salicina Se-RNase. The allele S(7)-RNase was found to be inactive by stylar protein isoelectric focusing followed by RNase-specific staining, but the reason for the inactivity was not at the coding sequence level. Further, in five of the 10 analyzed accessions, we detected the presence of one active basic RNase (marked PW(1)) that did not amplify with S-RNase-specific DNA primers. However, it was amplified with primers designed from the PA1 RNase nucleotide sequence (basic "non-S RNase" of Prunus avium) and the obtained sequence showed high homology (80%) with the PA1 allele. Although homologs of PA1 "non-S RNases" have been reported in four other Prunus species, this is the first recorded homolog in Prunus webbii. The evolutionary implications of the data are discussed.

Basic Finance

Science.gov (United States)

Vittek, J. F.

1972-01-01

A discussion of the basic measures of corporate financial strength, and the sources of the information is reported. Considered are: balance sheet, income statement, funds and cash flow, and financial ratios.

Settlement Networks in Polish Spatial Development Regional Plans

Science.gov (United States)

Sołtys, Jacek

2017-10-01

In 1999, ten years after the great political changes in Poland, 16 self-governed regions (in Polish: voivodeship) were created. According to Polish law, voivodeship spatial development plans, or regional plans in short, determine basic elements of the settlement network. No detailed regulations indicate the specific elements of the settlement network or what features of these elements should be determined. For this reason, centres as elements of the settlement network are variously named in different regions and take the form of various models. The purposes of the research described in this article are: (1) recognition and systematization of settlement network models determined in regional plans; and (2) assessment of the readability of determination in planning and its usefulness in the practice of regional policy. Six models of settlement networks in regional plans have been identified and classified into types and sub-types. Names of specific levels of centres indicate that they were classified according to two criteria: (1) level of services, which concerns only 5 voivodships; and (2) importance in development, which concerns the 11 other voivodships. The hierarchical model referring to the importance of development is less understandable than the one related to services. In the text of most plans, centres of services and centres of development are treated independently from their names. In some plans the functional types of towns and cities are indicated. In some voivodships, specifications in the plan text are too general and seem to be rather useless in the practice of regional policy. The author suggests that regional plans should determine two kinds of centres: hierarchical service centres and non-hierarchical centres of development. These centres should be further distinguished according to: (1) their role in the activation of surroundings; (2) their level of development and the necessity of action for their development; and (3) the types of actions

Paracantor: A two group, two region reactor code

Energy Technology Data Exchange (ETDEWEB)

Stone, Stuart

1956-07-01

Paracantor I a two energy group, two region, time independent reactor code, which obtains a closed solution for a critical reactor assembly. The code deals with cylindrical reactors of finite length and with a radial reflector of finite thickness. It is programmed for the 1.B.M: Magnetic Drum Data-Processing Machine, Type 650. The limited memory space available does not permit a flux solution to be included in the basic Paracantor code. A supplementary code, Paracantor 11, has been programmed which computes fluxes, .including adjoint fluxes, from the .output of Paracamtor I.

Basics of Desktop Publishing. Second Edition.

Science.gov (United States)

Beeby, Ellen; Crummett, Jerrie

This document contains teacher and student materials for a basic course in desktop publishing. Six units of instruction cover the following: (1) introduction to desktop publishing; (2) desktop publishing systems; (3) software; (4) type selection; (5) document design; and (6) layout. The teacher edition contains some or all of the following…

Solar Energy Basics | NREL

Science.gov (United States)

Solar Energy Basics Solar Energy Basics Solar is the Latin word for sun-a powerful source of energy that can be used to heat, cool, and light our homes and businesses. That's because more energy from the technologies convert sunlight to usable energy for buildings. The most commonly used solar technologies for

Learning Visual Basic NET

CERN Document Server

Liberty, Jesse

2009-01-01

Learning Visual Basic .NET is a complete introduction to VB.NET and object-oriented programming. By using hundreds of examples, this book demonstrates how to develop various kinds of applications--including those that work with databases--and web services. Learning Visual Basic .NET will help you build a solid foundation in .NET.

Regions on plasmid pCU1 required for the killing of Klebsiella pneumoniae.

OpenAIRE

Thatte, V; Gill, S; Iyer, V N

1985-01-01

Plasmid pCU1 was Kik+ (promotes killing of Klebsiella pneumoniae). All Tn5 insertions within the tra region of pCU1 were Kik-. Two other regions, kikA and kikB, were needed. They may be separated on different plasmids, but both must be mobilized into Klebsiella pneumoniae. Establishment of one kik region in K. pneumoniae followed by receipt of the second did not lead to killing. Kik was therefore intracellular and required concerted and transient action of both regions.

Experimental data for insulin-like growth factor-1 (IGF-1) and basic fibroblast growth factor (bFGF) in prevention of radiation myelopathy; Experimentelle Daten zum Einsatz von Insulin-Like Growth Factor-1 (IGF-1) und Basic Fibroblast Growth Factor (bFGF) zur Praevention einer Strahlenmyelopathie

Energy Technology Data Exchange (ETDEWEB)

Nieder, C. [Technische Univ. Muenchen (Germany). Klinik und Poliklinik fuer Strahlentherapie und Radiologische Onkologie; Price, R.E.; Rivera, B. [The Univ. of Texas, M. D. Anderson Cancer Center, Houston, TX (United States). Dept. of Veterinary Medicine and Surgery; Andratschke, N.; Kian Ang, K. [The Univ. of Texas, M. D. Anderson Cancer Center, Houston, TX (United States). Dept. of Experimental Radiation Oncology

2002-03-01

Background: Current models of radiation myelopathy provide a rationale for growth factor-based prevention strategies. Thus, we tested whether insulin-like growth factor-1 (IGF-1) and basic fibroblast growth factor (bFGF) alone or in combination modulate radiation tolerance of the rat cervical spinal cord. Materials and Methods: The cervical spinal cord of 68 adult Fisher F344 rats received a total dose of 30-36 Gy, given as a single fraction of 16 Gy followed by a second radiation dose of 14-20 Gy. Continuous intrathecal infusion of bFGF (44 rats) or saline (24 rats) into the cisterna magna was given concomitantly. A further experiment included 14 additional rats which were treated with subcutaneous injection of IGF-1 parallel to irradiation with a total dose of 34 Gy or 36 Gy. 20 rats received combined treatment, i.e. intrathecal infusion of bFGF plus subcutaneous injection of IGF-1, starting 24 hours before irradiation (total dose 33 Gy or 36 Gy) for a total of 4 days. Animals were followed until myelopathy developed or for a maximum of 12 months. Histopathologic examinations were performed post mortem. Results: Treatment with bFGF alone or IGF-1 alone increased the median time to myelopathy significantly. In the 36-Gy group, after combination treatment a comparable prolongation of latency was seen. Moreover, rats treated with 33 Gy and combined bFGF plus IGF-1 showed a significantly reduced risk of myelopathy, too (p = 0.0015). (orig.) [German] Hintergrund: Aktuelle Modelle zur Pathogenese der Strahlenmyelopathie lassen den praeventiven Einsatz von Wachstumsfaktoren sinnvoll erscheinen. Daher sollte ueberprueft werden, ob Insulin-Like Growth Factor-1 (IGF-1) und Basic Fibroblast Growth Factor (bFGF) als Einzelsubstanzen oder in Kombination die Strahlentoleranz des zervikalen Rueckenmarks von Ratten beeinflussen. Material und Methoden: Das Zervikalmark von 68 erwachsenen Fisher-F344-Ratten wurde mit zwei Einzelfraktionen bis insgesamt 30-36 Gy bestrahlt (16 Gy

Determination of uric acid in the presence of ascorbic acid with hexacyanoferrate lanthanum film modified electrode

International Nuclear Information System (INIS)

Wang Guangfeng; Meng Jian; Liu Hongying; Jiao Shoufeng; Zhang Wei; Chen Daolei; Fang Bin

2008-01-01

A glassy carbon electrode modified with LaHCF was constructed and was characterized by cyclic voltammetry (CV) and electrochemical impedance spectrum (EIS). The resulting LaHCF modified glassy carbon electrode had a good catalytic character on uric acid (UA) and was used to detect uric acid and ascorbic acid (AA) simultaneously. This modified electrode exhibits potent and persistent electron-mediating behavior followed by well-separated oxidation peaks towards UA and AA with activation overpotential. For UA and AA in mixture, one can well separate from the other with a potential large enough to allow the determination of one in presence of the other. The DPV peak currents obtained increased linearly on the UA in the range of 2.0 x 10 -7 to 1.0 x 10 -4 mol/L with the detection limit (signal-to-noise ratio was 3) for UA 1.0 x 10 -7 mol/L. The proposed method showed excellent selectivity and stability, and the determination of UA and AA simultaneously in urine was satisfactory

Finding Basic Writing's Place.

Science.gov (United States)

Sheridan-Rabideau, Mary P.; Brossell, Gordon

1995-01-01

Posits that basic writing serves a vital function by providing writing support for at-risk students and serves the needs of a growing student population that universities accept yet feel needs additional writing instruction. Concludes that the basic writing classroom is the most effective educational support for at-risk students and their writing.…

Identification of the basic structure of a glycolipid from Selenomonas ruminantium as β-glucosaminyl-1,6-glucosamine

International Nuclear Information System (INIS)

Kamio, Yoshiyuki; Kim, Kyo-Chang; Takahashi, Hajime

1972-01-01

Lipid materials extracted by chloroform-methanol from solvent and acid treated cells of Selenomonas ruminantium grown with valerate - 14 C were analyzed by thin-layer chromatography. At least 12 radioactive lipid materials were present in the extract. The major compound, designated as spot A, carried approximately 70% of radioactivity of this fraction. The spot A compound was purified by column and thin-layer chromatography and its chemical structure was studied. The basic structural unit of this material was tentatively identified as β-glucosaminyl-1, 6-glucosamine with O-acyl and amide linked fatty acids. (author)

Measuring student teachers' basic psychological needs

NARCIS (Netherlands)

dr Bob Koster; Dr. Jos Castelijns; Dr. Marjan Vermeulen; dr.ir. Quinta Kools

2012-01-01

In the Self-Determination Theory (SDT) basic psychological needs for relatedness, autonomy and competence are distinguished. Basic psychological need fulfilment is considered to be critical for human development and intrinsic motivation. In the Netherlands, the concept of basic psychological need

Measuring student teachers’ basic psychological needs

NARCIS (Netherlands)

Vermeulen, Marjan; Castelijns, Jos; Koster, Bob; Kools, Quinta

2018-01-01

In the Self–Determination Theory (SDT) basic psychological needs for relatedness, autonomy and competence are distinguished. Basic psychological need fulfilment is considered to be critical for human development and intrinsic motivation. In the Netherlands, the concept of basic psychological need

NMR characterisation of the minimal interacting regions of centrosomal proteins 4.1R and NuMA1: effect of phosphorylation

Directory of Open Access Journals (Sweden)

Bruix Marta

2010-01-01

Full Text Available Abstract Background Some functions of 4.1R in non-erythroid cells are directly related with its distinct sub-cellular localisation during cell cycle phases. During mitosis, 4.1R is implicated in cell cycle progression and spindle pole formation, and co-localizes with NuMA1. However, during interphase 4.1R is located in the nucleus and only partially co-localizes with NuMA1. Results We have characterized by NMR the structural features of the C-terminal domain of 4.1R and those of the minimal region (the last 64 residues involved in the interaction with NuMA1. This subdomain behaves as an intrinsically unfolded protein containing a central region with helical tendency. The specific residues implicated in the interaction with NuMA1 have been mapped by NMR titrations and involve the N-terminal and central helical regions. The segment of NuMA1 that interacts with 4.1R is phosphorylated during mitosis. Interestingly, NMR data indicates that the phosphorylation of NuMA1 interacting peptide provokes a change in the interaction mechanism. In this case, the recognition occurs through the central helical region as well as through the C-terminal region of the subdomain meanwhile the N-terminal region do not interact. Conclusions These changes in the interaction derived from the phosphorylation state of NuMA1 suggest that phosphorylation can act as subtle mechanism of temporal and spatial regulation of the complex 4.1R-NuMA1 and therefore of the processes where both proteins play a role.

Implementation of basic quality control tests for malaria medicines in Amazon Basin countries: results for the 2005-2010 period.

Science.gov (United States)

Pribluda, Victor S; Barojas, Adrian; Añez, Arletta; López, Cecilia G; Figueroa, Ruth; Herrera, Roxana; Nakao, Gladys; Nogueira, Fernando Ha; Pianetti, Gerson A; Povoa, Marinete M; Viana, Giselle Mr; Gomes, Margarete S Mendonça; Escobar, Jose P; Sierra, Olga L Muñoz; Norena, Susana P Rendon; Veloz, Raúl; Bravo, Marcy Silva; Aldás, Martha R; Hindssemple, Alison; Collins, Marilyn; Ceron, Nicolas; Krishnalall, Karanchand; Adhin, Malti; Bretas, Gustavo; Hernandez, Nelly; Mendoza, Marjorie; Smine, Abdelkrim; Chibwe, Kennedy; Lukulay, Patrick; Evans, Lawrence

2012-06-15

Ensuring the quality of malaria medicines is crucial in working toward malaria control and eventual elimination. Unlike other validated tests that can assess all critical quality attributes, which is the standard for determining the quality of medicines, basic tests are significantly less expensive, faster, and require less skilled labour; yet, these tests provide reproducible data and information on several critical quality attributes, such as identity, purity, content, and disintegration. Visual and physical inspection also provides valuable information about the manufacturing and the labelling of medicines, and in many cases this inspection is sufficient to detect counterfeit medicines. The Promoting the Quality of Medicines (PQM) programme has provided technical assistance to Amazon Malaria Initiative (AMI) countries to implement the use of basic tests as a key screening mechanism to assess the quality of malaria medicines available to patients in decentralized regions. Trained personnel from the National Malaria Control Programmes (NMCPs), often in collaboration with country's Official Medicine Control Laboratory (OMCL), developed country- specific protocols that encompassed sampling methods, sample analysis, and data reporting. Sampling sites were selected based on malaria burden, accessibility, and geographical location. Convenience sampling was performed and countries were recommended to store the sampled medicines under conditions that did not compromise their quality. Basic analytical tests, such as disintegration and thin layer chromatography (TLC), were performed utilizing a portable mini-laboratory. Results were originally presented at regional meetings in a non-standardized format that lacked relevant medicines information. However, since 2008 information has been submitted utilizing a template specifically developed by PQM for that purpose. From 2005 to 2010, the quality of 1,663 malaria medicines from seven AMI countries was evaluated, mostly

The Rac1 hypervariable region in targeting and signaling

Science.gov (United States)

Lam, B. Daniel; Hordijk, Peter L.

2013-01-01

Cellular signaling by small GTPases is critically dependent on proper spatio-temporal orchestration of activation and output. In addition to their core G (guanine nucleotide binding)-domain, small GTPases comprise a hypervariable region (HVR) and a lipid anchor that are generally accepted to control subcellullar localization. The HVR encodes in many small GTPases a polybasic region (PBR) that permits charge-mediated association to the inner leaflet of the plasma membrane or to intracellular organelles. Over the past 15–20 years, evidence has accumulated for specific protein–protein interactions, mediated by the HVR, that control both targeting and signaling specificity of small GTPases. Using the RhoGTPase Rac1 as a paradigm we here review a series of protein partners that require the Rac1 HVR for association and that control various aspects of localized Rac1 signaling. Some of these proteins represent Rac1 activators, whereas others mediate Rac1 inactivation and degradation and yet others potentiate Rac1 downstream signaling. Finally, evidence is discussed which shows that the HVR of Rac1 also contributes to effector interactions, co-operating with the N-terminal effector domain. The complexity of localized Rac1 signaling, reviewed here, is most likely exemplary for many other small GTPases as well, representing a challenge to identify and define similar mechanisms controlling the specific signaling induced by small GTPases. PMID:23354415

Relationship among expression of basic-fibroblast growth factor ...

African Journals Online (AJOL)

Relationship among expression of basic-fibroblast growth factor, MTDH/Astrocyte elevated gene-1, adenomatous polyposis coli, matrix metalloproteinase 9,and COX-2 markers with prognostic factors in prostate carcinomas.

Basic set theory

CERN Document Server

Levy, Azriel

2002-01-01

An advanced-level treatment of the basics of set theory, this text offers students a firm foundation, stopping just short of the areas employing model-theoretic methods. Geared toward upper-level undergraduate and graduate students, it consists of two parts: the first covers pure set theory, including the basic motions, order and well-foundedness, cardinal numbers, the ordinals, and the axiom of choice and some of it consequences; the second deals with applications and advanced topics such as point set topology, real spaces, Boolean algebras, and infinite combinatorics and large cardinals. An

Revisiting the Operating Room Basics

Directory of Open Access Journals (Sweden)

Tushar Chakravorty

2015-12-01

Full Text Available Young doctors walking into the operating room are eager to develop their skills to become efficient and knowledgeable professionals in future. But precious little is done to actively develop the basic practical skills of the budding doctors. They remain unaware about the layout of the operating room, the OR etiquette and often do not have sound scientific understanding and importance of meticulous execution of the basic operating room protocols. This article stresses the need to develop the basics of OR protocol and to improve the confidence of the young doctor by strengthening his foundation by showing him that attention to the basics of medical care and empathy for the patient can really make a difference to the outcome of a treatment.

The application of 10CFR830. 120 in a basic research environment

Energy Technology Data Exchange (ETDEWEB)

Bodnarczuk, M.

1991-04-01

In this paper, I describe the process of applying the 10 basic criteria of the proposed 10CFR830.120 to a basic research environment like Fermilab and discuss some of the issues associated with the implementation of such a program. I will also discuss some of the differences and similarities between the 18 basic elements of NQA-1 and the 10 criteria of 10CFR830.120 along with the more philosophical'' issues associated with performance versus process- based approach to quality in basic research.

Changing patterns of basic household consumption in the Inner Mongolian grasslands: a case study of policy-oriented adoptive changes in the use of grasslands

NARCIS (Netherlands)

Du, B.; Zhen, L.; Groot, de R.S.; Goulden, C.E.; Long, X.; Cao, X.; Wu, R.; Sun, C.

2014-01-01

Grassland ecosystems, as the basic natural resources in the Inner Mongolia Autonomous Region, are becoming increasingly sensitive to human intervention, leading to deterioration in fragile ecosystems. The goal of this study was to describe the restoration policy-oriented adoptive changes to basic

Parametric statistical inference basic theory and modern approaches

CERN Document Server

Zacks, Shelemyahu; Tsokos, C P

1981-01-01

Parametric Statistical Inference: Basic Theory and Modern Approaches presents the developments and modern trends in statistical inference to students who do not have advanced mathematical and statistical preparation. The topics discussed in the book are basic and common to many fields of statistical inference and thus serve as a jumping board for in-depth study. The book is organized into eight chapters. Chapter 1 provides an overview of how the theory of statistical inference is presented in subsequent chapters. Chapter 2 briefly discusses statistical distributions and their properties. Chapt

CO J=2-1 observations toward southern HII regions

International Nuclear Information System (INIS)

Martin, R.N.; Ruf, K.; Wilson, T.L.; Zimmermann, P.; Emerson, D.T.

1983-01-01

A spectral line receiver system developed at the Max-Planck-Institut fuer Radioastronomie in Bonn was installed on the ESO 3.6-m and 1-m telescopes in July 1981. The cooled mixer front end gave DSB receiver temperatures of 260-600 K at 230 GHz. The spectrometer was a 256 x 1 MHz filterbank. The authors have observed the CO 2-1 transition towards 42 positions corresponding to the brightest southern HII regions. (Auth.)

Concepcion de la Educacion Basica en Algunos Paises. Series Divulgaciones No. 1 (The Notion of Basic Education in Several Countries. Information Series No. 1).

Science.gov (United States)

Enriquez, Galo, Ed.

This booklet defines and considers basic education and reports on the concept as it is implemented and developed in Argentina, Colombia, Chile, Spain, and Peru. Basic education, as defined here, generally refers to the education of children between the ages of 7 and 16 years. Initial remarks define the issue and discuss general principles. The…

Increased native T1-values at the interventricular insertion regions in precapillary pulmonary hypertension.

Science.gov (United States)

Spruijt, Onno A; Vissers, Loek; Bogaard, Harm-Jan; Hofman, Mark B M; Vonk-Noordegraaf, Anton; Marcus, J Tim

2016-03-01

Cardiac magnetic resonance imaging of the pressure overloaded right ventricle (RV) of precapillary pulmonary hypertension (PH) patients, exhibits late gadolinium enhancement at the interventricular insertion regions, a phenomenon which has been linked to focal fibrosis. Native T1-mapping is an alternative technique to characterize myocardium and has the advantage of not requiring the use of contrast agents. The aim of this study was to characterize the myocardium of idiopathic pulmonary arterial hypertension (IPAH), systemic scleroderma related PH (PAH-Ssc) and chronic thromboembolic PH (CTEPH) patients using native T1-mapping and to see whether native T1-values were related to disease severity. Furthermore, we compared native T1-values between the different precapillary PH categories. Native T1-mapping was performed in 46 IPAH, 14 PAH-SSc and 10 CTEPH patients and 10 control subjects. Native T1-values were assessed using regions of interest at the RV and LV free wall, interventricular septum and interventricular insertion regions. In PH patients, native T1-values of the interventricular insertion regions were significantly higher than the native T1-values of the RV free wall, LV free wall and interventricular septum. Native T1-values at the insertion regions were significantly related to disease severity. Native T1-values were not different between IPAH, PAH-Ssc and CTEPH patients. Native T1-values of the interventricular insertion regions are significantly increased in precapillary PH and are related to disease severity. Native T1-mapping can be developed as an alternative technique for the characterization of the interventricular insertion regions and has the advantage of not requiring the use of contrast agents.

Clinical Correlations as a Tool in Basic Science Medical Education

Directory of Open Access Journals (Sweden)

Brenda J. Klement

2016-01-01

Full Text Available Clinical correlations are tools to assist students in associating basic science concepts with a medical application or disease. There are many forms of clinical correlations and many ways to use them in the classroom. Five types of clinical correlations that may be embedded within basic science courses have been identified and described. (1 Correlated examples consist of superficial clinical information or stories accompanying basic science concepts to make the information more interesting and relevant. (2 Interactive learning and demonstrations provide hands-on experiences or the demonstration of a clinical topic. (3 Specialized workshops have an application-based focus, are more specialized than typical laboratory sessions, and range in complexity from basic to advanced. (4 Small-group activities require groups of students, guided by faculty, to solve simple problems that relate basic science information to clinical topics. (5 Course-centered problem solving is a more advanced correlation activity than the others and focuses on recognition and treatment of clinical problems to promote clinical reasoning skills. Diverse teaching activities are used in basic science medical education, and those that include clinical relevance promote interest, communication, and collaboration, enhance knowledge retention, and help develop clinical reasoning skills.

Patterns Of Fulfillment Basic Needs On Rural Area Based On Palm Oil Plantation Community In Riau Province

Directory of Open Access Journals (Sweden)

Rita Yani Iyan

2017-12-01

Full Text Available The purpose of this study is to determine the distribution pattern stabilization of the availability of basic needs of rural communities based on oil palm commodities in Riau Province. The analytical method used is descriptive analysis. The data obtained is processed and tabulated into the frequency distribution which is then presented in the form of tables graphs and charts to explain the behavior of the variables studied. The results show that the pattern of distribution of basic needs in rural areas based on oil palm commodities in Riau Province is generally taken by land with the road surface conditions are relatively good and can be passed throughout the year. Distribution of basic necessities used in the form of shops grocery stores shopping groups to minimarket and permanent and non permanent markets. The prices of basic commodities are relatively fluctuating and tend to increase but they are still in a stable category. The availability of basic needs sources is seen from the area of land harvest and production decreased while consumption as the population increase. So that the supply of basic needs from outside the region is the road taken to ensure the availability of sufficient stock of basic needs.

Basic principle of cone beam computed tomography

International Nuclear Information System (INIS)

Choi, Yong Suk; Kim, Gyu Tae; Hwang, Eui Hwan

2006-01-01

The use of computed tomography for dental procedures has increased recently. Cone beam computed tomography(CBCT) systems have been designed for imaging hard tissues of the dentomaxillofacial region. CBCT is capable of providing high resolution in images of high diagnostic quality. This technology allows for 3-dimensional representation of the dentomaxillofacial skeleton with minimal distortion, but at lower equipment cost, simpler image acquisition and lower patient dose. Because this technology produces images with isotropic sub-millimeter spatial resolution, it is ideally suited for dedicated dentomaxillofacial imaging. In this paper, we provide a brief overview of cone beam scanning technology and compare it with the fan beam scanning used in conventional CT and the basic principles of currently available CBCT systems

Reference Sources: Little Known to Basic

Science.gov (United States)

RQ, 1970

1970-01-01

This article lists seventy-eight reference sources, and is divided into the following four sections: (1) Useful But Little-Known Reference Tools by John Fetros, (2) The Statesman's Year-Book by James Becker, (3) Single Volume Scientific Encyclopedias by Jack Clarke and (4) Ten Basic Sources of Business and Economic Statistics by James Woy. (MF)

Neural correlates of processing "self-conscious" vs. "basic" emotions.

Science.gov (United States)

Gilead, Michael; Katzir, Maayan; Eyal, Tal; Liberman, Nira

2016-01-29

Self-conscious emotions are prevalent in our daily lives and play an important role in both normal and pathological behavior. Despite their immense significance, the neural substrates that are involved in the processing of such emotions are surprisingly under-studied. In light of this, we conducted an fMRI study in which participants thought of various personal events which elicited feelings of negative and positive self-conscious (i.e., guilt, pride) or basic (i.e., anger, joy) emotions. We performed a conjunction analysis to investigate the neural correlates associated with processing events that are related to self-conscious vs. basic emotions, irrespective of valence. The results show that processing self-conscious emotions resulted in activation within frontal areas associated with self-processing and self-control, namely, the mPFC extending to the dACC, and within the lateral-dorsal prefrontal cortex. Processing basic emotions resulted in activation throughout relatively phylogenetically-ancient regions of the cortex, namely in visual and tactile processing areas and in the insular cortex. Furthermore, self-conscious emotions differentially activated the mPFC such that the negative self-conscious emotion (guilt) was associated with a more dorsal activation, and the positive self-conscious emotion (pride) was associated with a more ventral activation. We discuss how these results shed light on the nature of mental representations and neural systems involved in self-reflective and affective processing. Copyright © 2015 Elsevier Ltd. All rights reserved.

Effects of perceived autonomy support and basic need satisfaction on quality of life in hemodialysis patients.

Science.gov (United States)

Chen, Mei-Fang; Chang, Ray-E; Tsai, Hung-Bin; Hou, Ying-Hui

2018-03-01

Despite a growing understanding of health-related quality of life (HRQOL) and its determinants in hemodialysis (HD) patients, little is known about the effects and interrelationships concerning the perception of autonomy support and basic need satisfaction of HD patients on their HRQOL. Based on self-determination theory (SDT), this study examines whether HD patients' perceived autonomy support from health care practitioners (physicians and nurses) relates to the satisfaction of HD patients' basic needs and in turn influences their HRQOL. A questionnaire was administered to 250 Taiwanese HD patients recruited from multiclinical centers and regional hospitals in northern Taiwan. Structural equation modeling (SEM) analysis was conducted to examine the causal relationships between patient perceptions of autonomy support and HRQOL through basic need satisfaction. The empirical results of SEM indicated that the HD patients' perceived autonomy support increased the satisfaction of their basic needs (autonomy, competency, and relatedness), as expected. The higher degree of basic need satisfaction led to higher HRQOL, as measured by physical and mental component scores. Autonomy support from physicians and nurses contributes to improving HD patients' HRQOL through basic need satisfaction. This indicates that staff caring for patients with severe chronic diseases should offer considerable support for patient autonomy.

38 CFR 3.314 - Basic pension determinations.

Science.gov (United States)

2010-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false Basic pension determinations. 3.314 Section 3.314 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS ADJUDICATION Pension, Compensation, and Dependency and Indemnity Compensation Ratings and Evaluations; Service...

Interactive learning media based on flash for basic electronic engineering development for SMK Negeri 1 Driyorejo - Gresik

Science.gov (United States)

Mandigo Anggana Raras, Gustav

2018-04-01

This research aims to produce a product in the form of flash based interactive learning media on a basic electronic engineering subject that reliable to be used and to know students’ responses about the media. The target of this research is X-TEI 1 class at SMK Negeri 1 Driyorejo – Gresik. The method used in this study is R&D that has been limited into seven stages only (1) potential and problems, (2) data collection, (3) product design, (4) product validation, (5) product revision, (6) field test, and (7) analysis and writing. The obtained result is interactive learning media named MELDASH. Validation process used to produce a valid interactive learning media. The result of media validation state that the interactive learning media has a 90.83% rating. Students’ responses to this interactive learning media is really good with 88.89% rating.

North Central Regional environmental characterization report. Volume 1. Final report

International Nuclear Information System (INIS)

1985-08-01

This report presents available environmental information pertinent to siting a repository for high-level nuclear waste in crystalline rock in Minnesota, Wisconsin, and the Upper Peninsula of Michigan. For each of the states within the North Central Region, information is provided on those environmental disqualifying factors and regional screening variables to be used in region-to-area screening. These environmental factors and variables include existing and proposed Federal-protected lands, proximity to Federal-protected lands, components of national forest lands, existing state-protected lands, proximity to state-protected lands, population density and distribution, proximity to highly populated areas or to 1-mile square areas with 1000 or more persons, national and state forest lands, designated critical habitats for threatened and endangered spcies, surface water bodies, and wetlands. In addition, supplementary descriptive information providing a general characterization of the region is presented, as is information on environmental parameters that will be of use at later phases of screening. Also included is a discussion of the relationship between the US Department of Energy Siting Guidelines (10CFR 960) and those environmental disqualifying factors and regional screening variables to be used in the region-to-area screening process

Ribosomal L1 domain and lysine-rich region are essential for CSIG/ RSL1D1 to regulate proliferation and senescence

Energy Technology Data Exchange (ETDEWEB)

Ma, Liwei; Zhao, Wenting; Zheng, Quanhui; Chen, Tianda; Qi, Ji; Li, Guodong; Tong, Tanjun, E-mail: tztong@bjmu.edu.cn

2016-01-15

The expression change of cellular senescence-associated genes is underlying the genetic foundation of cellular senescence. Using a suppressive subtractive hybridization system, we identified CSIG (cellular senescence-inhibited gene protein; RSL1D1) as a novel senescence-associated gene. CSIG is implicated in various process including cell cycle regulation, apoptosis, and tumor metastasis. We previously showed that CSIG plays an important role in regulating cell proliferation and cellular senescence progression through inhibiting PTEN, however, which domain or region of CSIG contributes to this function? To clarify this question, we investigated the functional importance of ribosomal L1 domain and lysine (Lys) -rich region of CSIG. The data showed that expression of CSIG potently reduced PTEN expression, increased cell proliferation rates, and reduced the senescent phenotype (lower SA-β-gal activity). By contrast, neither the expression of CSIG N- terminal (NT) fragment containing the ribosomal L1 domain nor C-terminal (CT) fragment containing Lys-rich region could significantly altered the levels of PTEN; instead of promoting cell proliferation and delaying cellular senescence, expression of CSIG-NT or CSIG-CT inhibited cell proliferation and accelerated cell senescence (increased SA-β-gal activity) compared to either CSIG over-expressing or control (empty vector transfected) cells. The further immunofluorescence analysis showed that CSIG-CT and CSIG-NT truncated proteins exhibited different subcellular distribution with that of wild-type CSIG. Conclusively, both ribosomal L1 domain and Lys-rich region of CSIG are critical for CSIG to act as a regulator of cell proliferation and cellular senescence. - Highlights: • The ribosomal L1 domain and lysine-rich region of CSIG were expressed. • They are critical for CSIG to regulate proliferation and senescence. • CSIG and its domains exhibit different subcellular distribution.

Ribosomal L1 domain and lysine-rich region are essential for CSIG/ RSL1D1 to regulate proliferation and senescence

International Nuclear Information System (INIS)

Ma, Liwei; Zhao, Wenting; Zheng, Quanhui; Chen, Tianda; Qi, Ji; Li, Guodong; Tong, Tanjun

2016-01-01

The expression change of cellular senescence-associated genes is underlying the genetic foundation of cellular senescence. Using a suppressive subtractive hybridization system, we identified CSIG (cellular senescence-inhibited gene protein; RSL1D1) as a novel senescence-associated gene. CSIG is implicated in various process including cell cycle regulation, apoptosis, and tumor metastasis. We previously showed that CSIG plays an important role in regulating cell proliferation and cellular senescence progression through inhibiting PTEN, however, which domain or region of CSIG contributes to this function? To clarify this question, we investigated the functional importance of ribosomal L1 domain and lysine (Lys) -rich region of CSIG. The data showed that expression of CSIG potently reduced PTEN expression, increased cell proliferation rates, and reduced the senescent phenotype (lower SA-β-gal activity). By contrast, neither the expression of CSIG N- terminal (NT) fragment containing the ribosomal L1 domain nor C-terminal (CT) fragment containing Lys-rich region could significantly altered the levels of PTEN; instead of promoting cell proliferation and delaying cellular senescence, expression of CSIG-NT or CSIG-CT inhibited cell proliferation and accelerated cell senescence (increased SA-β-gal activity) compared to either CSIG over-expressing or control (empty vector transfected) cells. The further immunofluorescence analysis showed that CSIG-CT and CSIG-NT truncated proteins exhibited different subcellular distribution with that of wild-type CSIG. Conclusively, both ribosomal L1 domain and Lys-rich region of CSIG are critical for CSIG to act as a regulator of cell proliferation and cellular senescence. - Highlights: • The ribosomal L1 domain and lysine-rich region of CSIG were expressed. • They are critical for CSIG to regulate proliferation and senescence. • CSIG and its domains exhibit different subcellular distribution.

Nucleolar targeting of proteins by the tandem array of basic amino acid stretches identified in the RNA polymerase I-associated factor PAF49

International Nuclear Information System (INIS)

Ushijima, Ryujiro; Matsuyama, Toshifumi; Nagata, Izumi; Yamamoto, Kazuo

2008-01-01

There is accumulating evidence to indicate that the regulation of subnuclear compartmentalization plays important roles in cellular processes. The RNA polymerase I-associated factor PAF49 has been shown to accumulate in the nucleolus in growing cells, but disperse into the nucleoplasm in growth-arrested cells. Serial deletion analysis revealed that amino acids 199-338 were necessary for the nucleolar localization of PAF49. Combinatorial point mutation analysis indicated that the individual basic amino acid stretches (BS) within the central (BS1-4) and the C-terminal (BS5 and 6) regions may cooperatively confer the nucleolar localization of PAF49. Addition of the basic stretches in tandem to a heterologous protein, such as the interferon regulatory factor-3, translocated the tagged protein into the nucleolus, even in the presence of an intrinsic nuclear export sequence. Thus, tandem array of the basic amino acid stretches identified here functions as a dominant nucleolar targeting sequence

76 FR 5840 - The Basic Aluminum Castings Co., Cleveland, OH; Notice of Revised Determination on Reconsideration

Science.gov (United States)

2011-02-02

... DEPARTMENT OF LABOR Employment and Training Administration [TA-W-73,091] The Basic Aluminum... of America, Region 2B, requested administrative reconsideration of the negative determination... threatened with total or partial separation from employment on date of certification through two years from...

CSO BOLOCAM 1.1 mm CONTINUUM MAPPING OF THE BRAID NEBULA STAR FORMATION REGION IN CYGNUS OB7

International Nuclear Information System (INIS)

Aspin, Colin; Beck, Tracy L.; Davis, Chris J.

2011-01-01

We present a 1.1 mm map of the Braid Nebula star formation region in Cygnus OB7 taken using Bolocam on the Caltech Submillimeter Observatory. Within the 1 deg 2 covered by the map, we have detected 55 cold dust clumps all of which are new detections. A number of these clumps are coincident with IRAS point sources although the majority are not. Some of the previously studied optical/near-IR sources are detected at 1.1 mm. We estimate total dust/gas masses for the 55 clumps together with peak visual extinctions. We conclude that over the whole region, approximately 20% of the clumps are associated with IRAS sources suggesting that these are protostellar objects. The remaining 80% are classed as starless clumps. In addition, both FU Orionis (FUor) like objects in the field, the Braid Star and HH 381 IRS, are associated with strong millimeter emission. This implies that FUor eruptions can occur at very early stages of pre-main-sequence life. Finally, we determine that the cumulative clump mass function for the region is very similar to that found in both the Perseus and ρ Ophiuchus star-forming regions.

Monoclonal Antibodies Directed toward the Hepatitis C Virus Glycoprotein E2 Detect Antigenic Differences Modulated by the N-Terminal Hypervariable Region 1 (HVR1), HVR2, and Intergenotypic Variable Region.

Science.gov (United States)

Alhammad, Yousef; Gu, Jun; Boo, Irene; Harrison, David; McCaffrey, Kathleen; Vietheer, Patricia T; Edwards, Stirling; Quinn, Charles; Coulibaly, Fásseli; Poumbourios, Pantelis; Drummer, Heidi E

2015-12-01

Hepatitis C virus (HCV) envelope glycoproteins E1 and E2 form a heterodimer and mediate receptor interactions and viral fusion. Both E1 and E2 are targets of the neutralizing antibody (NAb) response and are candidates for the production of vaccines that generate humoral immunity. Previous studies demonstrated that N-terminal hypervariable region 1 (HVR1) can modulate the neutralization potential of monoclonal antibodies (MAbs), but no information is available on the influence of HVR2 or the intergenotypic variable region (igVR) on antigenicity. In this study, we examined how the variable regions influence the antigenicity of the receptor binding domain of E2 spanning HCV polyprotein residues 384 to 661 (E2661) using a panel of MAbs raised against E2661 and E2661 lacking HVR1, HVR2, and the igVR (Δ123) and well-characterized MAbs isolated from infected humans. We show for a subset of both neutralizing and nonneutralizing MAbs that all three variable regions decrease the ability of MAbs to bind E2661 and reduce the ability of MAbs to inhibit E2-CD81 interactions. In addition, we describe a new MAb directed toward the region spanning residues 411 to 428 of E2 (MAb24) that demonstrates broad neutralization against all 7 genotypes of HCV. The ability of MAb24 to inhibit E2-CD81 interactions is strongly influenced by the three variable regions. Our data suggest that HVR1, HVR2, and the igVR modulate exposure of epitopes on the core domain of E2 and their ability to prevent E2-CD81 interactions. These studies suggest that the function of HVR2 and the igVR is to modulate antibody recognition of glycoprotein E2 and may contribute to immune evasion. This study reveals conformational and antigenic differences between the Δ123 and intact E2661 glycoproteins and provides new structural and functional data about the three variable regions and their role in occluding neutralizing and nonneutralizing epitopes on the E2 core domain. The variable regions may therefore function to

Proceedings of the 3. Regional Meeting on Radiological and Nuclear Safety. Radiological protection in Latin America and the Caribbean. Vol. 1,2; Actas del 3. Congreso Regional sobre Seguridad Radiologica y Nuclear. Proteccion Radiologica en America Latina y el Caribe. Vol. 1,2

Energy Technology Data Exchange (ETDEWEB)

NONE

1996-08-01

Two volumes contain more than 183 complete papers presented during the Third Regional Meeting on Radiological Protection and Nuclear Safety held on 23-27 October, 1995 in Cusco-Peru. Latin american specialist talk about nuclear safety and radiological protection, radiation natural exposure, biological effect of radiation, radiotherapy and medical radiological safety, radiological safety in industry and research. Also we deal with subjects related to radiological safety of nuclear and radioactive facilities, radioactive waste management, radioactive material transport, environmental radiological monitoring program, radiological emergency and accidents, instruments and dosimetry, basic safety standards of protection against radiation.

Basic Energy Sciences at NREL

International Nuclear Information System (INIS)

Moon, S.

2000-01-01

NREL's Center for Basic Sciences performs fundamental research for DOE's Office of Science. Our mission is to provide fundamental knowledge in the basic sciences and engineering that will underpin new and improved renewable energy technologies

First regional CSM program planned.

Science.gov (United States)

1982-09-01

6 countries in the English-speaking Caribbean (Antigua, Barbados, Dominica, St. Kitts/Nevis, St. Lucia, and St. Vincent) are scheduled to form the 1st regional contraceptive social marketing program. The program will be under the auspices of the Barbados Family Planning Association. By combining resources, contraceptive social marketing should be able to effectively augment family planning activities in smaller countries where individual programs wuld be too costly. The regional program will also determine whether program elements from 1 country in a region are relevant in other countries. The Caribbean region as a whole has experienced a general decline in both crude birth rates and fertility rates during the past 15 years; however, adolescent fertility rates remain high and an average of 46% of the populations of Caribbean countries are under 15 years of age. Although heavy emigration has traditionally curbed population increases, new restrictive immigration laws are expected. Further increases in the working age population will contribute to already high unemployment rates and hinder economic development. The 6 countries selected for the social marketing program are receptive to innovative family planning approaches and have the basic marketing infrastructure required. Community-based distribution programs already in operation in these countries distribute condoms, oral contraceptives, and barrier methods. The success of these programs has plateaued, and there is a need for delivery systems capable of reaching broader segments of the population. The social marketing program will be phased in to ensure local acceptance among national leaders and consumers. The regional program hopes to borrow elements from Jamaica's contraceptive social marketing program to avoid the costs involved in starting a program from scratch. A major innovation will be the use of mass media advertising for contraceptives.

What Selected Basic Schools in Western Zambia are Best At in ...

African Journals Online (AJOL)

Items 1 - 18 ... SIPs for each piloting basic school in our study would significantly contribute to a raised professional ..... Was focused on mutual gains and equality in partnership between the UNZA, basic .... comparative education, audio-visual programmes and so on - all dwelling on the selected ... totality if funds do not allow.

Genetic dissection of growth, wood basic density and gene expression in interspecific backcrosses of Eucalyptus grandis and E. urophylla

Science.gov (United States)

2012-01-01

Background F1 hybrid clones of Eucalyptus grandis and E. urophylla are widely grown for pulp and paper production in tropical and subtropical regions. Volume growth and wood quality are priority objectives in Eucalyptus tree improvement. The molecular basis of quantitative variation and trait expression in eucalypt hybrids, however, remains largely unknown. The recent availability of a draft genome sequence (http://www.phytozome.net) and genome-wide genotyping platforms, combined with high levels of genetic variation and high linkage disequilibrium in hybrid crosses, greatly facilitate the detection of quantitative trait loci (QTLs) as well as underlying candidate genes for growth and wood property traits. In this study, we used Diversity Arrays Technology markers to assess the genetic architecture of volume growth (diameter at breast height, DBH) and wood basic density in four-year-old progeny of an interspecific backcross pedigree of E. grandis and E. urophylla. In addition, we used Illumina RNA-Seq expression profiling in the E. urophylla backcross family to identify cis- and trans-acting polymorphisms (eQTLs) affecting transcript abundance of genes underlying QTLs for wood basic density. Results A total of five QTLs for DBH and 12 for wood basic density were identified in the two backcross families. Individual QTLs for DBH and wood basic density explained 3.1 to 12.2% of phenotypic variation. Candidate genes underlying QTLs for wood basic density on linkage groups 8 and 9 were found to share trans-acting eQTLs located on linkage groups 4 and 10, which in turn coincided with QTLs for wood basic density suggesting that these QTLs represent segregating components of an underlying transcriptional network. Conclusion This is the first demonstration of the use of next-generation expression profiling to quantify transcript abundance in a segregating tree population and identify candidate genes potentially affecting wood property variation. The QTLs identified in this

PERANCANGAN SISTEM PENCATATAN PAJAK REKLAME PADA DINAS PENDAPATAN KOTA PEKANBARU DENGAN METODE VISUAL BASIC

Directory of Open Access Journals (Sweden)

Feri Wongso

2016-10-01

Full Text Available Abstrak: Penelitian ini dilakukan untuk mengetahui sistem Pencatatan  pajak reklame terhadap Pendapatan Asli Daerah dan mengetahui perkembangan realisasi pajak reklame, Pendapatan Asli Daerah dan pengaruh Penerimaan Pajak Reklame terhadap Pendapatan Asli Daerah.Tujuan Penelitian ini adalah untuk: (1 Mengetahui Sistem Pencatatan pajak reklame dalam meningkatkan pendapatan asli daerah pada Dinas Pendapatan (2 Mengetahui kontribusi pencatatan pajak reklame dalam meningkatkan pendapatan asli daerah pada Dinas Pendapatan.Metode yang digunakan adalah metode Penelitian Kepustakaan merupakan metode yang dilakukan dengan cara mempelajari, meneliti, dan menelaah berbagai literatur. Data yang digunakan adalah Realisasi Pajak Reklame dan Realisasi Dinas Pendapatan Kota pekanbaru tahun 2016. Teknik pengumpulan data yang dilakukan adalah penelitian lapangan dengan cara observasi.Hasil dari penelitian ini menunjukkan bahwa pencatatan pajak reklame sebaiknya menggunakan Program Ms. Visual Basic Sehingga pencatatan pajak reklame tidak ada lagi kesalahan dan dapat meningkatkan Pendapatan Asli Daerah. Abstract: This study was conducted to determine the advertisement tax Registration System to Local Revenue and know the progress of realization advertisement tax, regional revenue and the effect of Advertisement Tax Revenue to Local Revenue.The purpose of this study was to: (1 Determine the advertisement tax Recording System in increasing revenue at the Department of Revenue (2 Knowing the contribution of advertisement tax record in increasing revenue at the Department of Revenue.The method used is the literature research method is a method that is done by studying, researching, and studying literature. The data used is the realization of advertisement tax and Actual Revenue Service pekanbaru 2016. The data collection technique is a field research conducted by observation.The results of this study indicate that the recording should use the advertising tax Program

The RSZ BASIC programming language manual

Science.gov (United States)

Stattel, R. J.; Niswander, J. K.; Kochhar, A. K.

1980-01-01

The RSZ BASIC interactive language is described. The RSZ BASIC interpreter is resident in the Telemetry Data Processor, a system dedicated to the processing and displaying of PCM telemetry data. A series of working examples teaches the fundamentals of RSZ BASIC and shows how to construct, edit, and manage storage of programs.

Oncology. Pt. 1. General part, epidemiology - pathogenesis - basic principles of therapy. 2. upd. ed.; Die Onkologie. T. 1. Allgemeiner Teil, Epidemiologie - Pathogenese - Grundprinzipien der Therapie

Energy Technology Data Exchange (ETDEWEB)

Hiddemann, Wolfgang [Muenchen Univ. Klinikum Grosshadern (Germany). Medizinische Klinik und Poliklinik III; Bartram Claus R. (eds.) [Heidelberg Univ. (Germany). Inst. fuer Humangenetik

2010-07-01

The book Oncology is aimed to communicate the compiled knowledge on tumor development and cancer: fundamental knowledge base, practice related know-how for diagnostics and therapy. Part 1 includes the following chapters: epidemiology and pathogenesis, basic principles of diagnostics, basic principles of therapy, complication of malign growth, tumors in the gastrointestinal tract, female genital carcinomas, kidney and urinary tract carcinomas, respiratory tract and lung carcinomas, carcinomas in the head - neck area, bone and soft tissue carcinomas, pediatric tumors, hematological neoplasm, other carcinomas. The book can be used as reference for clinical work. [German] Die gesamte Onkologie - verlaessliches Wissen fuer Ihre Kompetenz. ''Die Onkologie'' stellt sich der Herausforderung, das staendig wachsende Wissen ueber Tumorerkrankungen in seiner Gesamtheit zu vermitteln. Sowohl inhaltlich als auch didaktisch auf hoechsten Niveau: Fundiertes Grundlagenwissen zum umfassenden Nachschlagen Praxisrelevantes Know-how fuer Diagnostik und Therapie Systematischer Aufbau fuer das Verstaendnis der komplexen Zusammenhaenge Die Onkologie - eine Enzyklopaedie der modernen klinischen Tumorlehre. Angesehene Experten aus Klinik, Forschung und Praxis liefern Ihnen in Teil1 klinisches Grundlagenwissen zu den Grundprinzipien der Therapie, Epidemiologie, Aetiologie und Pathogenese, sowie zu Komplikationen des malignen Wachstums. Zum Nachschlagen und Anwenden: finden Sie alle Optionen - auch fuer Ihren schwierigsten Fall. Der uebersichtliche Aufbau und die exzellenten Abbildungen erleichtern Ihnen das schnelle Auffinden und Verstaendnis der gesuchten Informationen. Fuer den Alltag onkologisch taetiger Aerzte ist Die Onkologie ein unentbehrlicher Meilenstein. (orig.)

Interactive computing in BASIC an introduction to interactive computing and a practical course in the BASIC language

CERN Document Server

Sanderson, Peter C

1973-01-01

Interactive Computing in BASIC: An Introduction to Interactive Computing and a Practical Course in the BASIC Language provides a general introduction to the principles of interactive computing and a comprehensive practical guide to the programming language Beginners All-purpose Symbolic Instruction Code (BASIC). The book starts by providing an introduction to computers and discussing the aspects of terminal usage, programming languages, and the stages in writing and testing a program. The text then discusses BASIC with regard to methods in writing simple arithmetical programs, control stateme

Basic Energy Sciences at NREL

Energy Technology Data Exchange (ETDEWEB)

Moon, S.

2000-12-04

NREL's Center for Basic Sciences performs fundamental research for DOE's Office of Science. Our mission is to provide fundamental knowledge in the basic sciences and engineering that will underpin new and improved renewable energy technologies.

Basics of LASIK Eye Surgery

Science.gov (United States)

... Vea esta página en español The Basics of LASIK Eye Surgery Share This Page Facebook Twitter Linked- ... Surgery Surgical Alternatives to LASIK For More Information  LASIK Basics If you wear glasses or contact lenses, ...

The influence of regional deprivation index on personal happiness using multilevel analysis.

Science.gov (United States)

Kim, Kil Hun; Chun, Jin-Ho; Sohn, Hae Sook

2015-01-01

The objective of the present study was to identify the factors that influence the happiness index of community residents, by considering personal and regional aspects, and to use as evidence of efforts for improvement of the happiness index. The study was conducted based on information from 16,270 participants who met the data requirement among those who participated in the 2011 South Gyeongsang Community Health Survey. Of the factors that can influence the happiness index, socioeconomic characteristics, health behavior, morbidity, and healthcare use, social contact, and participation in social activities were classified as personal factors; for regional factors, data from the 2010 census were used to extrapolate the regional deprivation indices at the submunicipal-level (eup, myeon, and dong) in South Gyeongsang Province. The happiness index for each characteristic was compared to that for others via t-test and ANOVA, and multilevel analysis was performed, using four models: a basic model for identification of only random effects, model 1 for identification of personal factors, model 2 for identification of regional factors, and model 3 for simultaneous consideration of both personal and regional factors. The mean happiness index was 63.2 points (64.6 points in males and 62.0 points in females), while the mean deprivation index was -1.58 points. In the multilevel analysis, the regional-level variance ratio of the basic model was 10.8%, confirming interregional differences. At the personal level, higher happiness indices were seen in groups consisting of males with high educational level, high income, high degree of physical activity, sufficient sleep, active social contact, and participation in social activities; whereas lower happiness indices were seen in people who frequently skipped breakfast, had unmet healthcare needs, and had accompanying diseases, as well as those with higher deprivation index. The study confirmed that the happiness index of community

The influence of regional deprivation index on personal happiness using multilevel analysis

Directory of Open Access Journals (Sweden)

Kil Hun Kim

2015-04-01

Full Text Available OBJECTIVES: The objective of the present study was to identify the factors that influence the happiness index of community residents, by considering personal and regional aspects, and to use as evidence of efforts for improvement of the happiness index. METHODS: The study was conducted based on information from 16,270 participants who met the data requirement among those who participated in the 2011 South Gyeongsang Community Health Survey. Of the factors that can influence the happiness index, socioeconomic characteristics, health behavior, morbidity, and healthcare use, social contact, and participation in social activities were classified as personal factors; for regional factors, data from the 2010 census were used to extrapolate the regional deprivation indices at the submunicipal-level (eup, myeon, and dong in South Gyeongsang Province. The happiness index for each characteristic was compared to that for others via t-test and ANOVA, and multilevel analysis was performed, using four models: a basic model for identification of only random effects, model 1 for identification of personal factors, model 2 for identification of regional factors, and model 3 for simultaneous consideration of both personal and regional factors. RESULTS: The mean happiness index was 63.2 points (64.6 points in males and 62.0 points in females, while the mean deprivation index was -1.58 points. In the multilevel analysis, the regional-level variance ratio of the basic model was 10.8%, confirming interregional differences. At the personal level, higher happiness indices were seen in groups consisting of males with high educational level, high income, high degree of physical activity, sufficient sleep, active social contact, and participation in social activities; whereas lower happiness indices were seen in people who frequently skipped breakfast, had unmet healthcare needs, and had accompanying diseases, as well as those with higher deprivation index. CONCLUSIONS

Geophysical Investigations in the Caucasus (1925 - 2012): Initial, Basic and Modern Stages

Science.gov (United States)

Eppelbaum, L. V.

2012-04-01

The Caucasian Mountains occupy an area of about 440,000 km2. A number of important mineral resources are concentrated there. Geophysical data on the geological structure of Caucasus can shed light on the basic principles of evolution of the Earth, the distribution of minerals and seismic activity. However, geophysical surveys under complex conditions are generally riddled by poor accessibility to certain mountainous regions, the unevenness of observation surfaces, as well as by a great variety and frequent changes of tectonic structures and geological bodies with variable physical properties. These factors either restrict geophysical surveys in difficult environments or confine the scope of useful information drawn from the results obtained. This has led to the development of special techniques in geophysical surveys, data processing and interpretation that draws heavily on the experience accumulated in the specific conditions of these mountainous regions. First applied geophysical observations in the Caucasus region - thermal measurements in boreholes - were carried out by Bazevich (1881) in the Absheron Peninsula. At the same time, start of the initial stage is usually referred to as the mid 20-s of the XX century, when the rare, but systematic geophysical observations (mainly gravity and magnetic) were begun in some Caucasian areas. Somewhat later began to apply the resistivity method. Mid 30-s is characterized by the beginning of application of borehole geophysics and seismic prospecting. The marine seismics firstly in the former Soviet Union was tested in the Caspian Sea. In general, the initial stage is characterized by slow, but steady rise (except during World War II) lasted until 1960. A basic stage (1960-1991) is characterized by very intensive employment of geophysical methods (apparently, any possible geophysical methods were tested in this region). At this time the Caucasus region is considered in the former Soviet Union as a geophysical polygon for

Radio observations of the CMa OB1 H II regions

International Nuclear Information System (INIS)

Gaylard, M.J.; Kemball, A.J.

1984-01-01

A sensitive 10 0 x 15 0 13-cm map made of the CMa OB1 H II regions' radio emission shows a strong similarity to Hα emission photographs. Sharpless 296 is shown to consist of a prominent central and western arc completed by a weaker southern loop, and with a faint northern bar. The emission is thermal, superimposed over a predominantly non-thermal background. The H142α recombination line has been detected at eight positions in S296, and in S292 and S297. The average electron temperature in S296 is 6900 +- 1300 K. The UV fluxes from the CMa OB1 stars account for the observed emission measures of the H II regions. The H142α 1sr velocities indicate that the ionized material is in contact with the molecular clouds. (author)

Public libraries in the library regions in the year 2009

Directory of Open Access Journals (Sweden)

Milena Bon

2011-01-01

Full Text Available Purpose: Regional public libraries were initiated in 2003 to connect professional activities of libraries within regional networks and to ensure coordinated library development in a region in cooperation with the Library System Development Centre at the National and University Library performing a coordinating role. The article analyses the performance of public libraries and their integration in regional library networks in order to find out the level of development of conditions of performance of public libraries.Methodology/approach: Statistical data for the year 2009 were the basis for the overview of library activities of ten library regions with regard to applicable legislation and library standards. The level of regional library activities is compared to the socio-economic situation of statistical regions thus representing a new approach to the presentation of Slovenian’s public libraries’ development.Results: Absolute values indicate better development of nine libraries in the central Slovenia region while relative values offer a totally different picture. Four libraries in the region of Nova Gorica prove the highest level of development.Research limitation: Research is limited to the year 2009 and basic statistical analysis.Originality/practical implications: Findings of the analysis are useful for public libraries to plan their development strategy within a region and for financial bodies to provide for adequate financing for library activities in a specific region. The basic condition for successful public library performance is the even and harmonized development of conditions of performance as recommended by library standards.

E-Basics: Online Basic Training in Program Evaluation

Science.gov (United States)

Silliman, Ben

2016-01-01

E-Basics is an online training in program evaluation concepts and skills designed for youth development professionals, especially those working in nonformal science education. Ten hours of online training in seven modules is designed to prepare participants for mentoring and applied practice, mastery, and/or team leadership in program evaluation.…

Interaction region

International Nuclear Information System (INIS)

Anon.

1982-01-01

The Interaction Region Group addressed the basic questions of how to collide the SLC beams, how to maximize and monitor the luminosity, and how to minimize the detector backgrounds at the interaction region. In practice, five subgroups evolved to study these questions. The final focus group provided three alternative designs to acheive the 1 to 2 micron beam spot size required by the SLC, as well as studying other problems including: eta, eta' matching from the collider arcs, the implementation of soft bends near the interaction region, beam emittance growth, and magnet tolerances in the final focus. The beam position monitor group proposed two devices, a strip line monitor, and a beamstrahlung monitor, to bring the beams into collision. The luminosity monitor group reviewed the possible QED processes that would be insensitive to weak interaction (Z 0 ) effects. The beam dumping group proposed locations for kicker and septum magnets in the final focus that would achieve a high dumping efficiency and would meet the desired beam tolerances at the Moller scattering target in the beam dump line. Working with the Polarization Group, the Moller experiment was designed into the beam dump beam line. A beam dump was proposed that would maintain radiation backgrounds (penetrating muons) at acceptible levels. The detector backgrounds group proposed soft-bend and masking configurations to shield the detector from synchrotron radiation from the hard/soft bends and from the final focus quadrupoles and evaluated the effectiveness of these designs for the three final focus optics designs. Backgrounds were also estimated from: large angle synchrotron radiation, local and distant beam-gas interactions, 2-photon interactions, and from neutrons and backscattered photons from the beamstrahlung dump

On acceleration of <1 MeV/n He ions in the corotating compression regions near 1 AU: STEREO observations

Directory of Open Access Journals (Sweden)

R. Bučík

2009-09-01

Full Text Available Observations of multi-MeV corotating interaction region (CIR ions are in general consistent with models of CIR shock acceleration and transport. The presence of suprathermal particles near 1 AU in unshocked compression regions is not adequately explained. Nonetheless, more recent works demonstrate that unshocked compression regions associated with CIRs near 1 AU could energize particles. In the energy range from ~0.1 to ~1 MeV/n we investigate CIR events observed in 2007–2008 by the STEREO A and B spacecraft. We treat the predictions of compression acceleration by comparing the observed ion intensities with the model parameters. These observations show that the ion intensity in CIR events with in-situ reverse shock is well organized by the parameters which characterize the compression region itself, like compression width, solar wind speed gradients and the total pressure. In turn, for CIR events with the absence of the shocks the model predictions are not fulfilled.

The Basic Economics of CD-ROM Pricing.

Science.gov (United States)

Erkkila, John E.

1991-01-01

This explanation of how the basic economic model of pricing applies to the CD-ROM industry considers the supply and demand sides of the market and compares three distinct pricing strategies: (1) pricing to maximize profits; (2) average cost pricing; and (3) marginal cost pricing. (EAM)

Impurity levels and fatigue lives of pseudoelastic NiTi shape memory alloys

International Nuclear Information System (INIS)

Rahim, M.; Frenzel, J.; Frotscher, M.; Pfetzing-Micklich, J.; Steegmüller, R.; Wohlschlögel, M.; Mughrabi, H.; Eggeler, G.

2013-01-01

In the present work we show how different oxygen (O) and carbon (C) levels affect fatigue lives of pseudoelastic NiTi shape memory alloys. We compare three alloys, one with an ultrahigh purity and two which contain the maximum accepted levels of C and O. We use bending rotation fatigue (up to cycle numbers >10 8 ) and scanning electron microscopy (for investigating microstructural details of crack initiation and growth) to study fatigue behavior. High cycle fatigue (HCF) life is governed by the number of cycles required for crack initiation. In the low cycle fatigue (LCF) regime, the high-purity alloy outperforms the materials with higher number densities of carbides and oxides. In the HCF regime, on the other hand, the high-purity and C-containing alloys show higher fatigue lives than the alloy with oxide particles. There is high experimental scatter in the HCF regime where fatigue cracks preferentially nucleate at particle/void assemblies (PVAs) which form during processing. Cyclic crack growth follows the Paris law and does not depend on impurity levels. The results presented in the present work contribute to a better understanding of structural fatigue of pseudoelastic NiTi shape memory alloys

Regional tourist industry in context of principles of regional socioeconomic systems self-regulation

Directory of Open Access Journals (Sweden)

Andrey Gennadyevich Shelomentsev

2011-03-01

Full Text Available This paper deals with basic principles of self-regulation of tourist complexes as regional socio-economic systems on the example of Sverdlovsk region. These include the principles of goal setting and the necessary diversity of economic entropy: in this case, these are important for the tourism industry and the human and natural resource and ecological potential. Is it shown how a tourist complex influences the socio-economic development of regional economic systems. In particular, tourism influences some of migration processes. Tourism development strategy in the Russian Federation at the tourist center level is analyzed. The need to develop such a strategy is due to the transition to market relations and, as a consequence, complexity of governmental regulation. It is substantiated that Sverdlovsk region is a subject to following strategy and might be successful in various sectors of tourism: business and congress and exhibition, urban entertainment, family and shopping tourism, sports, medical and recreational tourism.

Characterization of Cer-1 cis-regulatory region during early Xenopus development.

Science.gov (United States)

Silva, Ana Cristina; Filipe, Mário; Steinbeisser, Herbert; Belo, José António

2011-05-01

Cerberus-related molecules are well-known Wnt, Nodal, and BMP inhibitors that have been implicated in different processes including anterior–posterior patterning and left–right asymmetry. In both mouse and frog, two Cerberus-related genes have been isolated, mCer-1 and mCer-2, and Xcer and Xcoco, respectively. Until now, little is known about the mechanisms involved in their transcriptional regulation. Here, we report a heterologous analysis of the mouse Cerberus-1 gene upstream regulatory regions, responsible for its expression in the visceral endodermal cells. Our analysis showed that the consensus sequences for a TATA, CAAT, or GC boxes were absent but a TGTGG sequence was present at position -172 to -168 bp, relative to the ATG. Using a series of deletion constructs and transient expression in Xenopus embryos, we found that a fragment of 1.4 kb of Cer-1 promoter sequence could reproduce the endogenous expression pattern of Xenopus cerberus. A 0.7-kb mcer-1 upstream region was able to drive reporter expression to the involuting mesendodermal cells, while further deletions abolished reporter gene expression. Our results suggest that although no sequence similarity was found between mouse and Xenopus cerberus cis-regulatory regions, the signaling cascades regulating cerberus expression, during gastrulation, is conserved.

Implementation of multi-regional energy balances for Slovenia

International Nuclear Information System (INIS)

Suvorov, B.; Schechtner, O.; Zelle, K.; Andjelic, M.W.

1994-01-01

The system used for preparing energy balances for Styria and 17 Styrian districts, which was developed by ADIP-GRAZ in accordance with the federal energy balance of Austria, is being applied to Slovenia. Energy balances are a necessary tool for monitoring the impact of measures initiated by the energy policy. Therefore balances are of a basic mutual interest, also in connection with balances of air pollutants that can be calculated from energy balances. The official Slovenian energy balance for the year 1990 is the basis for implementation of regional balances for five chosen regions (Maribor region, Celje region, Ljubljana region, Littoral region, and Upper-Slovenia region). Results are presented according to defined concepts and structures which are closely related to the MEDEE-RS methodology. (Author)

Tyrosinase degradation is prevented when EDEM1 lacks the intrinsically disordered region.

Directory of Open Access Journals (Sweden)

Marioara B Marin

Full Text Available EDEM1 is a mannosidase-like protein that recruits misfolded glycoproteins from the calnexin/calreticulin folding cycle to downstream endoplasmic reticulum associated degradation (ERAD pathway. Here, we investigate the role of EDEM1 in the processing of tyrosinase, a tumour antigen overexpressed in melanoma cells. First, we analyzed and modeled EDEM1 major domains. The homology model raised on the crystal structures of human and Saccharomyces cerevisiae ER class I α1,2-mannosidases reveals that the major mannosidase domain located between aminoacids 121-598 fits with high accuracy. We have further identified an N-terminal region located between aminoacids 40-119, predicted to be intrinsically disordered (ID and susceptible to adopt multiple conformations, hence facilitating protein-protein interactions. To investigate these two domains we have constructed an EDEM1 deletion mutant lacking the ID region and a triple mutant disrupting the glycan-binding domain and analyzed their association with tyrosinase. Tyrosinase is a glycoprotein partly degraded endogenously by ERAD and the ubiquitin proteasomal system. We found that the degradation of wild type and misfolded tyrosinase was enhanced when EDEM1 was overexpressed. Glycosylated and non-glycosylated mutants co-immunoprecipitated with EDEM1 even in the absence of its intact mannosidase-like domain, but not when the ID region was deleted. In contrast, calnexin and SEL 1L associated with the deletion mutant. Our data suggest that the ID region identified in the N-terminal end of EDEM1 is involved in the binding of glycosylated and non-glycosylated misfolded proteins. Accelerating tyrosinase degradation by EDEM1 overexpression may lead to an efficient antigen presentation and enhanced elimination of melanoma cells.

Solar Process Heat Basics | NREL

Science.gov (United States)

Process Heat Basics Solar Process Heat Basics Commercial and industrial buildings may use the same solar technologies-photovoltaics, passive heating, daylighting, and water heating-that are used for residential buildings. These nonresidential buildings can also use solar energy technologies that would be

STRATEGIC MANAGEMENT AND MEASUREMENT OF COMPETITIVENESS OF REGIONS ON EXAMPLE OF COUNTRIES EU

Directory of Open Access Journals (Sweden)

Ladislav ROLÍNEK

2008-07-01

Full Text Available The aim of this paper is to outline the substance of strategic management in relation to regional development with focus on the basic indicators that evaluate regional competitive advantage. Strategic management presents the collection of methods and approaches that are applicable to the regulation of regional development. The basic requirement of this process is to increase competitive advantage of the regions. It is possible to define regional competitive advantage as the ability of regions to generate revenues and keep employment rate at a level corresponding to national and international competition. The level of regional competitiveness is, for example, measurable by GDP per capita index. Besides this indicator, we can also use the evaluation of labour productivity expressed as GDP per employee as well as the ratio of employable population to the total of economically active inhabitants. For these monitored indicators, the Czech Republic doesn’t belong to the best countries. It is on the 19th place among the countries of EU in GDP per capita and it is also not very good in productivity evaluation, expressed by GDP per employee (20th place. On the other hand, the Czech Republic belongs among the countries with quite high employment rate (12th place. An application of the point method shows that the Czech Republic is on 18th place according to an average of selected indicators resulting from the GDP description per resident. It reaches only 70.2% of the level of the leading country, Luxemburg. The results of the article were obtained in the frame of the project MSM 6007665806 a MPSV 1J 016/04-DP2.

Analysis of tissue-specific region in sericin 1 gene promoter of Bombyx mori

Energy Technology Data Exchange (ETDEWEB)

Yan, Liu [College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou 310027 (China); Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031 (China); Lian, Yu [College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou 310027 (China); Zhejiang Province Key Laboratory of Preventive Veterinary Medicine, Institute of Preventive Veterinary Medicine, Zhejiang University, Hangzhou 310029 (China); Xiuyang, Guo [Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031 (China); Tingqing, Guo [Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031 (China); Shengpeng, Wang [Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031 (China); Changde, Lu [Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031 (China)

2006-03-31

The gene encoding sericin 1 (Ser1) of silkworm (Bombyx mori) is specifically expressed in the middle silk gland cells. To identify element involved in this transcription-dependent spatial restriction, truncation of the 5' terminal from the sericin 1 (Ser1) promoter is studied in vivo. A 209 bp DNA sequence upstream of the transcriptional start site (-586 to -378) is found to be responsible for promoting tissue-specific transcription. Analysis of this 209 bp region by overlapping deletion studies showed that a 25 bp region (-500 to -476) suppresses the ectopic expression of the Ser1 promoter. An unknown factor abundant in fat body nuclear extracts is shown to bind to this 25 bp fragment. These results suggest that this 25 bp region and the unknown factor are necessary for determining the tissue-specificity of the Ser1 promoter.

Basic Color Terms in Estonian Sign Language

Science.gov (United States)

Hollman, Liivi; Sutrop, Urmas

2011-01-01

The article is written in the tradition of Brent Berlin and Paul Kay's theory of basic color terms. According to this theory there is a universal inventory of eleven basic color categories from which the basic color terms of any given language are always drawn. The number of basic color terms varies from 2 to 11 and in a language having a fully…

APLIKASI PERPUSTAKAAN PADA SMA N1 KELUMBAYAN BARAT MENGGUNAKAN VISUAL BASIC

Directory of Open Access Journals (Sweden)

Rita Irviani

2017-06-01

Full Text Available The purpose of making the library application was to simplify the data seaching process and make the librarian easier such as borrow and return books and to know the late of returning books at the library. Model of Visual Basic (VB was used in the development of this system. There were some necessary data in making the application such as members,books, borrowers, returning, rack book, and category book. From the data it was expected could be the basis to present the important informasion quicly and accurately. Because the system in saving and manage the data were changed from manual become computerized it was expedted to make the librarian prosess more effective.

f-Element Ion Chelation in Highly Basic Media - Final Report

International Nuclear Information System (INIS)

Paine, R.T.

2000-01-01

A large body of data has been collected over the last fifty years on the chemical behavior of f-element ions. The ions undergo rapid hydrolysis reactions in neutral or basic aqueous solutions that produce poorly understood oxide-hydroxide species; therefore, most of the fundamental f-element solution chemistry has allowed synthetic and separations chemists to rationally design advanced organic chelating ligands useful for highly selective partitioning and separation of f-element ions from complex acidic solution matrices. These ligands and new examples under development allow for the safe use and treatment of solutions containing highly radioactive species. This DOE/EMSP project was undertaken to address the following fundamental objectives: (1) study the chemical speciation of Sr and lanthanide (Ln) ions in basic aqueous media containing classical counter anions found in waste matrices; (2) prepare pyridine N-oxide phosphonates and phosphonic acids that might act as selective chelator s for Ln ions in model basic pH waste streams; (3) study the binding of the new chelators toward Ln ions and (4) examine the utility of the chelators as decontamination and dissolution agents under basic solution conditions. The project has been successful in attacking selected aspects of the very difficult problems associated with basic pH solution f-element waste chemistry. In particular, the project has (1) shed additional light on the initial stages of Ln ion sol-gel-precipitate formulation under basic solution conditions; (2) generated new families of pyridine phosphonic acid chelators; (3) characterized the function of the chelators and (4) examined their utility as oxide-hydroxide dissolution agents. These findings have contributed significantly to an improved understanding of the behavior of Ln ions in basic media containing anions found in typical waste sludges as well as to the development of sludge dissolution agents. The new chelating reagents are easily made and could be

Variability or conservation of hepatitis C virus hypervariable region 1?

Indian Academy of Sciences (India)

The hypervariable region 1 (HVR1) of the E2 protein of hepatitis C virus (HCV) is highly heterogeneous in its primary sequence and is responsible for significant inter- and intra-individual variation of the infecting virus, which may represent an important pathogenetic mechanism leading to immune escape and persistent ...

Body Basics

Science.gov (United States)

... learn more about how the body works, what basic human anatomy is, and what happens when parts of ... consult your doctor. © 1995- The Nemours Foundation. All rights reserved. Images provided by The Nemours Foundation, iStock, Getty Images, Veer, Shutterstock, and Clipart.com.

A basic research on the transient behavior for a metallic fuel FBR

International Nuclear Information System (INIS)

Baba, Mamoru; Hirano, Go; Kawada, Ken-ichi; Niwa, Hajime

1999-03-01

A metallic fuel with novel design has received great deal of interest recently as an option of advanced fuel to be substituted MOX fuel, however, the behavior at the transient has not been studied in many aspects. Therefore, for the purpose to show the basic tendency of the behavior and released energy at CDA (core disruptive accident) for a metallic fuel FBR and to prepare the basic knowledge for consideration of the adoption of the advanced fuel, Tohoku university and Power Reactor and Nuclear Fuel Development Corporation have made a joint research entitled 'A basic research on the transient behavior for a metallic fuel FBR'. The results are the following. (1) Target and Results of analysis: The accident initiator considered is a LOF accident without scram. The LOF analysis was performed for a metallic fuel 600 MWe homogeneous two region core at the beginning of cycle, both for an ordinary metallic fuel core and for a metallic fuel core with ZrH pins. It was necessary mainly to change the constants of input parameters to apply the code for the analysis of a metallic fueled reactor. These changes were made by assuming appropriate models. Basic LOF cases and all blackout case that assumed using electromagnetic pumps were analyzed. The results show that the basic LOF cases for a metallic fuel core and all the cases for a metallic fuel core with ZrH pins could be avoided to become prompt-critical, and mildly transfer to the transition phase. It is shown that the moderator is quite elective to mitigate the accident at the initiation phase. However, it is necessary to analyze the transition phase to know if the re-criticality is totally avoided after the initiation phase. (2) Improvement of CDA initiation phase analysis code: At present, it is difficult for the code to adapt to the large scale material movement in the core at the transient. Therefore, the nuclear calculation model in the code was improved by using the adiabatic space dependent kinetics, and examined

Evolutionary and Expression Analyses of the Apple Basic Leucine Zipper Transcription Factor Family

Science.gov (United States)

Zhao, Jiao; Guo, Rongrong; Guo, Chunlei; Hou, Hongmin; Wang, Xiping; Gao, Hua

2016-01-01

Transcription factors (TFs) play essential roles in the regulatory networks controlling many developmental processes in plants. Members of the basic leucine (Leu) zipper (bZIP) TF family, which is unique to eukaryotes, are involved in regulating diverse processes, including flower and vascular development, seed maturation, stress signaling, and defense responses to pathogens. The bZIP proteins have a characteristic bZIP domain composed of a DNA-binding basic region and a Leu zipper dimerization region. In this study, we identified 112 apple (Malus domestica Borkh) bZIP TF-encoding genes, termed MdbZIP genes. Synteny analysis indicated that segmental and tandem duplication events, as well as whole genome duplication, have contributed to the expansion of the apple bZIP family. The family could be divided into 11 groups based on structural features of the encoded proteins, as well as on the phylogenetic relationship of the apple bZIP proteins to those of the model plant Arabidopsis thaliana (AtbZIP genes). Synteny analysis revealed that several paired MdbZIP genes and AtbZIP gene homologs were located in syntenic genomic regions. Furthermore, expression analyses of group A MdbZIP genes showed distinct expression levels in 10 different organs. Moreover, changes in these expression profiles in response to abiotic stress conditions and various hormone treatments identified MdbZIP genes that were responsive to high salinity and drought, as well as to different phytohormones. PMID:27066030

Evolutionary and Expression Analyses of the Apple Basic Leucine Zipper Transcription Factor Family

Directory of Open Access Journals (Sweden)

Jiao eZhao

2016-03-01

Full Text Available Transcription factors (TFs play essential roles in the regulatory networks controlling many developmental processes in plants. Members of the basic leucine (Leu zipper (bZIP TF family, which is unique to eukaryotes, are involved in regulating diverse processes, including flower and vascular development, seed maturation, stress signaling and defense responses to pathogens. The bZIP proteins have a characteristic bZIP domain composed of a DNA-binding basic region and a Leu zipper dimerization region. In this study, we identified 112 apple (Malus domestica Borkh bZIP TF-encoding genes, termed MdbZIP genes. Synteny analysis indicated that segmental and tandem duplication events, as well as whole genome duplication, have contributed to the expansion of the apple bZIP family. The family could be divided into 11 groups based on structural features of the encoded proteins, as well as on the phylogenetic relationship of the apple bZIP proteins to those of the model plant Arabidopsis thaliana (AtbZIP genes. Synteny analysis revealed that several paired MdbZIP genes and AtbZIP gene homologs were located in syntenic genomic regions. Furthermore, expression analyses of group A MdbZIP genes showed distinct expression levels in ten different organs. Moreover, changes in these expression profiles in response to abiotic stress conditions and various hormone treatments identified MdbZIP genes that were responsive to high salinity and drought, as well as to different phytohormones.

Solar Photovoltaic Technology Basics | NREL

Science.gov (United States)

Photovoltaic Technology Basics Solar Photovoltaic Technology Basics Solar cells, also called found in sand) created an electric charge when exposed to sunlight. Soon solar cells were being used to power space satellites and smaller items like calculators and watches. Photo of a large silicon solar

Radioactivity of food products in the region of the ''Kozloduj'' atomic power station in the pre-exploitation period

International Nuclear Information System (INIS)

Jotov, M.; Petkov, T.; Zlatanova, R.; Boyadzhiev, A.

1976-01-01

The pre-exploitation status of the region of the ''Kozloduj'' atomic power stationand its torch zone, regarding the concentration of the biologically most dangerous artificial isotopes in the basic food products was determined. The tested foods were milk, meat, wheat, fish and grapes produced at the most important and basic production regions in the controled region. The radioactive isotope concentrations in the analyzed food produxts are reported. They will serve as a basis in assessing any eventual additional contamination of the region as a result of the work of the ''Kozloduj'' electric power station. (author)

Development NGOs: Basic Facts

OpenAIRE

Aldashev, Gani; Navarra, Cecilia

2017-01-01

This paper systematizes the results of the empirical literature on development non-governmental organizations (NGOs), drawing both from quantitative and qualitative analyses, and constructs a set of basic facts about these organizations. These basic facts concern the size of the development NGO sector and its evolution, the funding of NGOs, the allocation of NGO aid and projects across beneficiary countries, the relationship of NGOs with beneficiaries, and the phenomenon of globalization of d...

Clinical teachers' tacit knowledge of basic pedagogic principles.

Science.gov (United States)

McLeod, P J; Meagher, T; Steinert, Y; Schuwirth, L; McLeod, A H

2004-02-01

Academic faculty members in medical schools rarely receive formal instruction in basic pedagogic principles; nevertheless many develop into competent teachers. Perhaps they acquire tacit knowledge of these principles with teaching experience. This study was designed to assess clinical teachers' tacit knowledge of basic pedagogic principles and concepts. The authors developed a multiple-choice question (MCQ) exam based on 20 pedagogic principles judged by a panel of education experts to be important for clinical teaching. Three groups of clinician-educators sat the test: (1) clinicians with advanced education training and experience; (2) internal medicine specialists; (3) surgical specialists. All four groups of clinicians-educators passed the test, indicating that they possess a reasonable tacit knowledge of basic pedagogic principles. Those with advanced education training performed much better than members of the other two groups while specialists and residents working in teaching hospitals outperformed specialists from non-teaching hospitals. It is possible that converting this tacit knowledge to explicit knowledge may improve individual teaching effectiveness.

The basic research on the CDA initiation phase for a metallic fuel FBR

International Nuclear Information System (INIS)

Hirano, Go; Hirakawa, Naohiro; Kawada, Ken-ichi; Niwa, Hazime

1998-03-01

A metallic fuel with novel design has received great deal of interest recently as an option of advanced fuel to be substituted MOX fuel, however, the behavior at the transient has not been studied in many aspects. Therefore, for the purpose to show the basic tendency of the behavior and released energy at CDA (core disruptive accident) for a metallic fuel FBR and to prepare the basic knowledge for consideration of the adoption of the advanced fuel, Tohoku University and Power Reactor and Nuclear Fuel Development Corporation have made a joint research entitled. (1) Target and Results of analysis: The accident initiator considered is a LOF accident with ATWS. The LOF analysis was performed for a metallic fuel 600 MWe homogeneous two region core at the beginning of cycle, both for an ordinary metallic fuel core and for a metallic fuel core with ZrH pins. It was necessary mainly to change the constants of input parameters to apply the code for the analysis of a metallic fueled reactor. These changes were made by assuming appropriate models. Basic LOF cases and all blackout case that assumed using electromagnetic pumps were analyzed. The results show that the basic LOF cases for a metallic fuel core and all the cases for a metallic fuel core with ZrH pins could be avoided to become prompt-critical, and mildly transfer to the transient phase. (2) Improvement of CDA initiation phase analysis code: At present, it is difficult for the code to adapt to the large material movement to in the core at the transient. Therefore, the nuclear calculation model in the code was improved by using the adiabatic space dependent kinetics. The results of a sample case, that is a metallic fueled core at the beginning of cycle, show this improvement is appropriate. (3) Conclusion: The behavior at CDA of a metallic fueled core of a fast reactor was analyzed using the CDA initiation phase analysis code and the knowledge of the important characteristics at the CDA initiation phase was obtained

Output formatting in Apple-Soft Basic

International Nuclear Information System (INIS)

Navale, A.S.

1987-01-01

Personal computers are being used extensively in various fields. BASIC is a very popular and widely used language in personal computers. Apple computer is one of the popular machines used for scientific and engineering applications. Presenting output from computers in a neat and easy to read form is very important. Languages like FORTRAN have utility command 'FORMAT' which takes care of the formatting of the output in user-defined form. In some versions of BASIC a PRINT USING facility is available but it is not as powerful as the FORTRAN statement 'FORMAT'. Applesoft basic does not have even this PRINT USING command. Programmers have to write their own program segments to handle output formatting in Applesoft BASIC. Generally, such user written programs are of limited use as they cannot be used easily with other programs. A general purpose and easily transportable subroutine in Applesoft BASIC is presented here for handling output formatting in user-defined structure. The subroutine is nearly as powerful as the FORMAT statement in FORTRAN. It can also be used in other versions of BASIC with very little modifications. 3 tables, 4 refs. (author)

Fuel Cell Vehicle Basics | NREL

Science.gov (United States)

Fuel Cell Vehicle Basics Fuel Cell Vehicle Basics Researchers are developing fuel cells that can be silver four-door sedan being driven on a roadway and containing the words "hydrogen fuel cell electric" across the front and rear doors. This prototype hydrogen fuel cell electric vehicle was

Basic principles of concrete structures

CERN Document Server

Gu, Xianglin; Zhou, Yong

2016-01-01

Based on the latest version of designing codes both for buildings and bridges (GB50010-2010 and JTG D62-2004), this book starts from steel and concrete materials, whose properties are very important to the mechanical behavior of concrete structural members. Step by step, analysis of reinforced and prestressed concrete members under basic loading types (tension, compression, flexure, shearing and torsion) and environmental actions are introduced. The characteristic of the book that distinguishes it from other textbooks on concrete structures is that more emphasis has been laid on the basic theories of reinforced concrete and the application of the basic theories in design of new structures and analysis of existing structures. Examples and problems in each chapter are carefully designed to cover every important knowledge point. As a basic course for undergraduates majoring in civil engineering, this course is different from either the previously learnt mechanics courses or the design courses to be learnt. Compa...

Reflex sympathetic dystrophy/complex regional pain syndrome, type 1

African Journals Online (AJOL)

Enrique

with MRI every 3 months and the bone marrow oedema disappeared after 6 months. Introduction ... SA JOURNAL OF RADIOLOGY • August 2004. Reflex sympathetic dystrophy/complex regional pain syndrome, type 1 ... may be either trauma of external origin or iatrogenic, post surgery. In some patients particularly children ...

A brief simulation intervention increasing basic science and clinical knowledge

Directory of Open Access Journals (Sweden)

Maria L. Sheakley

2016-04-01

Full Text Available Background: The United States Medical Licensing Examination (USMLE is increasing clinical content on the Step 1 exam; thus, inclusion of clinical applications within the basic science curriculum is crucial. Including simulation activities during basic science years bridges the knowledge gap between basic science content and clinical application. Purpose: To evaluate the effects of a one-off, 1-hour cardiovascular simulation intervention on a summative assessment after adjusting for relevant demographic and academic predictors. Methods: This study was a non-randomized study using historical controls to evaluate curricular change. The control group received lecture (n l=515 and the intervention group received lecture plus a simulation exercise (nl+s=1,066. Assessment included summative exam questions (n=4 that were scored as pass/fail (≥75%. USMLE-style assessment questions were identical for both cohorts. Descriptive statistics for variables are presented and odds of passage calculated using logistic regression. Results: Undergraduate grade point ratio, MCAT-BS, MCAT-PS, age, attendance at an academic review program, and gender were significant predictors of summative exam passage. Students receiving the intervention were significantly more likely to pass the summative exam than students receiving lecture only (P=0.0003. Discussion: Simulation plus lecture increases short-term understanding as tested by a written exam. A longitudinal study is needed to assess the effect of a brief simulation intervention on long-term retention of clinical concepts in a basic science curriculum.

Very pre-term infants' behaviour at 1 and 2 years of age and parental stress following basic developmental care

NARCIS (Netherlands)

Pal, S.M. van der; Maguire, C.M.; Bruil, J.; Cessie, S. le; Zwieten, P. van; Veen, S.; Wit, J.M.; Walther, F.J.

2008-01-01

This study explored the effects of basic developmental care on the behaviour of very pre-term infants and parental stress at I and 2 years of corrected age. A randomized controlled trial was done to compare basic Developmental Care (standardized nests and incubator covers) and controls (standard

BASIC Instructional Program: System Documentation.

Science.gov (United States)

Dageforde, Mary L.

This report documents the BASIC Instructional Program (BIP), a "hands-on laboratory" that teaches elementary programming in the BASIC language, as implemented in the MAINSAIL language, a machine-independent revision of SAIL which should facilitate implementation of BIP on other computing systems. Eight instructional modules which make up…

Basic Electromagnetism and Materials

CERN Document Server

Moliton, André

2007-01-01

Basic Electromagnetism and Materials is the product of many years of teaching basic and applied electromagnetism. This textbook can be used to teach electromagnetism to a wide range of undergraduate science majors in physics, electrical engineering or materials science. However, by making lesser demands on mathematical knowledge than competing texts, and by emphasizing electromagnetic properties of materials and their applications, this textbook is uniquely suited to students of materials science. Many competing texts focus on the study of propagation waves either in the microwave or optical domain, whereas Basic Electromagnetism and Materials covers the entire electromagnetic domain and the physical response of materials to these waves. Professor André Moliton is Director of the Unité de Microélectronique, Optoélectronique et Polymères (Université de Limoges, France), which brings together three groups studying the optoelectronics of molecular and polymer layers, micro-optoelectronic systems for teleco...

Instructional Supervisory Practices of Headteachers and Teacher Motivation in Public Basic Schools in Anomabo Education Circuit

Science.gov (United States)

Esia-Donkoh, Kweku; Baffoe, Stella

2018-01-01

The study examined the supervisory practices of headteachers and how these supervisory practices relate with teacher motivation in public basic schools in the Anomabo Education Circuit of the Mfantseman Municipality in the Central Region of Ghana. Quantitative approach of the cross-sectional survey design was adopted. Using purposive and…

BASIC DENSITY AND RETRACTIBILITY OF WOOD CLONES OF THREE Eucalyptus SPECIES

Directory of Open Access Journals (Sweden)

Djeison Cesar Batista

2010-12-01

Full Text Available Among the planted forests that supply the national wood industry, the genus Eucalyptus has become the most important, due to its fast growth, ease of large scale planting and variability of wood use. The generation of new hybrids and clones is a reality in the national practice of silviculture, and there is great interest currently in finding genetic improvements, mainly for higher volumetric gains and resistance in rough conditions of planting, such as pest attacks, periods of drought, low soil fertility, etc. The basic density is one of the most important physical properties of wood because it relates directly to other properties, including the anisotropic shrinkage. Such properties indicate the rational use of a species in a certain wood product. The aim of this work was to determine the basic density and the anisotropic shrinkage of five wood clones for each one of the following species: Eucalyptus saligna, Eucalyptus grandis and Eucalyptus dunnii. Clone 5 of Eucalyptus saligna presented the highest basic density (0.56 g/cm³ and was the most dimensionally instable. Of all the species, there was only a direct relation among basic density, maximum volumetric shrinkage and maximum volumetric shrinkage coefficient in this clone. Considering maximum volumetric shrinkage as the criterion, clone 3 was the most dimensionally stable. Clones 2 and 3 of Eucalyptus grandis presented the least and the highest basic density, respectively, with 0.40 and 0.49 g/cm³. It was not possible to distinguish among clones 1, 3 and 4 in terms of dimensional stability, and considering maximum volumetric shrinkage coefficient as the criterion, clone 5 was the most dimensionally instable. For Eucalyptus saligna and Eucalyptus dunnii it was not possible to distinguish which clone presented the least basic density. Clone 3 of Eucalyptus dunnii presented the highest basic density (0.65 g/cm³ and considering maximum volumetric shrinkage coefficient as the criterion, it

Report on state of the environment of the Trencin region to 2002

International Nuclear Information System (INIS)

Proksa, P.; Rolkova, M.; Adamkovicova, A.; Bebej, J.; Bodova, E.; Bohus, P.; Bracinikova, J.; Gajdos, L.; Goryczkova, A.; Hajnikova, M.; Chocholova; Jancarik, A.; Jecmenova, I.; Kanianska, R.; Kapusta, P.; Knazovicka, J.; Kovalova, A.; Kralik, A.; Lacuska, M.; Novacky, K.; Slamkova, M.; Vaculcikova, B.; Merka, M.

2003-01-01

The report on state of environment of the Trencin region to 2002 is presented. In this report the following parts are reviewed: Basic information about region; Compositions of the environment and their protection; Nature protection and landscape management; Environmental regional classification of the environment; Reasons and consequences of the environment; Risk factors in the environment; Environmental care

Report on state of the environment of the Bratislava region to 2002

International Nuclear Information System (INIS)

Proksa, P.; Rolkova, M.; Tvrdon, M.; Adamkovicova, A.; Bebej, J.; Bodova, E.; Bohus, P.; Bracinikova, J.; Gajdos, L.; Goryczkova, A.; Hajnikova, M.; Hanzel, L.; Chocholova; Jancarik, A.; Jecmenova, I.; Kanianska, R.; Kapusta, P.; Knazovicka, J.; Kovalova, A.; Kralik, A.; Lacuska, M.; Rostannska, Z.; Merka, M.

2003-01-01

he report on state of environment of the Bratislava region to 2002 is presented. In this report the following parts are reviewed: Basic information about region; Compositions of the environment and their protection; Nature protection and landscape management; Environmental regional classification of the environment; Reasons and consequences of the environment; Risk factors in the environment; Environmental care

Report on state of the environment of the Trnava region to 2002

International Nuclear Information System (INIS)

Proksa, P.; Rolkova, M.; Hlavata, K.; Adamkovicova, A.; Bebej, J.; Bodova, E.; Bohus, P.; Bracinikova, J.; Gajdos, L.; Goryczkova, A.; Hajnikova, M.; Halabrinova, K.; Hornanova, T.; Hyrrossova, K.; Chocholova; Jancarik, A.; Jecmenova, I.; Kanianska, R.; Kapusta, P.; Knazovicka, J.; Kovalova, A.; Kralik, A.; Lacuska, M.; Lazorissak, V.; Malik, J.; Psenakova, I.; Sekova, E.; Stevicova, L.; Vagasky, V.

2003-01-01

The report on state of environment of the Nitra region to 2002 is presented. In this report the following parts are reviewed: Basic information about region; Compositions of the environment and their protection; Nature protection and landscape management; Environmental regional classification of the environment; Reasons and consequences of the environment; Risk factors in the environment; Environmental care

Report on state of the environment of the Kosice region to 2002

International Nuclear Information System (INIS)

Proksa, P.; Rolkova, M.; Gehinova, B.; Dzurdzenik, J.; Adamkovicova, A.; Bebej, J.; Bodova, E.; Bodova, E.; Bohus, P.; Bracinikova, J.; Bysicka, L.; Dugasova, J.; Gajdos, L.; Gazarek, G.; Goryczkova, A.; Hajnikova, M.; Chocholova; Jancarik, A.; Jecmenova, I.; Kanianska, R.; Kapusta, P.; Kliment, P.; Knazovicka, J.; Kovalova, A.; Kralik, A.; Lacuska, M.; Matecek, L.; Palgutova, N.; Vagasky, V.; Bysicka, L.; Hajduova, J.; Mierka, M.; Prievoznik, J.

2003-01-01

The report on state of environment of the Kosice region to 2002 is presented. In this report the following parts are reviewed: Basic information about region; Compositions of the environment and their protection; Nature protection and landscape management; Environmental regional classification of the environment; Reasons and consequences of the environment; Risk factors in the environment; Environmental care

Report on state of the environment of the Nitra region to 2002

International Nuclear Information System (INIS)

Proksa, P.; Rolkova, M.; Hlavata, K.; Adamkovicova, A.; Bebej, J.; Bodova, E.; Bohus, P.; Bracinikova, J.; Gajdos, L.; Goryczkova, A.; Hajnikova, M.; Halabrinova, K.; Hornanova, T.; Hyrrossova, K.; Chocholova; Jancarik, A.; Jecmenova, I.; Kanianska, R.; Kapusta, P.; Knazovicka, J.; Kovalova, A.; Kralik, A.; Lacuska, M.; Lazorissak, V.; Malik, J.; Psenakova, I.; Sekova, E.; Stevicova, L.; Vagasky, V.

2003-01-01

The report on state of environment of the Nitra region to 2002 is presented. In this report the following parts are reviewed: Basic information about region; Compositions of the environment and their protection; Nature protection and landscape management; Environmental regional classification of the environment; Reasons and consequences of the environment; Risk factors in the environment; Environmental care

Report on state of the environment of the Zilina region to 2002

International Nuclear Information System (INIS)

Proksa, P.; Rolkova, M.; Adamkovicova, A.; Barciakova, E.; Bebej, J.; Bodova, E.; Bohus, P.; Bracinikova, J.; Gajdos, L.; Goryczkova, A.; Hajnikova, M.; Chocholova; Jecmenova, I.; Kanianska, R.; Kapusta, P.; Knazovicka, J.; Kovalova, A.; Kosecky, J.; Kralik, A.; Lacuska, M.; Matecek, L.; Rihalova, A.; Merka, M.; Prievoznik, J.

2003-01-01

The report on state of environment of the Zilina region to 2002 is presented. In this report the following parts are reviewed: Basic information about region; Compositions of the environment and their protection; Nature protection and landscape management; Environmental regional classification of the environment; Reasons and consequences of the environment; Risk factors in the environment; Environmental care

Report on state of the environment of the Presov region to 2002

International Nuclear Information System (INIS)

Proksa, P.; Rolkova, M.; Gajdos, L.; Adamkovicova, A.; Bebej, J.; Bodova, E.; Bohus, P.; Bracinikova, J.; Durbakova, Z.; Goryczkova, A.; Hajnikova, M.; Hanzel, L.; Chocholova; Jancarik, A.; Jecmenova, I.; Kanianska, R.; Kapusta, P.; Knazovicka, J.; Kovalova, A.; Kralik, A.; Lacuska, M.; Mudronova, M.; Vagasky, V.; Merka, M.