WorldWideScience

Sample records for hazardous cargo transportation

  1. 76 FR 4847 - Hazardous Materials: Safety Requirements for External Product Piping on Cargo Tanks Transporting...

    Science.gov (United States)

    2011-01-27

    ...: Safety Requirements for External Product Piping on Cargo Tanks Transporting Flammable Liquids AGENCY... flammable liquids in unprotected external product piping on DOT specification cargo tank motor vehicles. If... specification cargo tank motor vehicle (CTMV), unless the vehicle is equipped with bottom damage...

  2. 76 FR 14643 - Hazardous Materials: Safety Requirements for External Product Piping on Cargo Tanks Transporting...

    Science.gov (United States)

    2011-03-17

    ...: Safety Requirements for External Product Piping on Cargo Tanks Transporting Flammable Liquids AGENCY... external product piping (wetlines) on a cargo tank motor vehicle (CTMV) unless the CTMV is equipped with... National Tank Truck Carriers, Inc., and the Tank Truck Manufacturers Association requesting an extension...

  3. Groupage Cargo Transportation Model

    Directory of Open Access Journals (Sweden)

    Aleksejevs Ruslans

    2016-03-01

    Full Text Available In this work we consider a specific problem of optimal planning of maritime transportation of multiproduct cargo by ships of one (corporate strategy or several (partially corporate strategy companies: the core of the problem consists of the existence of the network of intermediate seaports (i.e. transitional seaports, where for every ship arrived the cargo handling is done, and which are situated between the starting and the finishing seaports. In this work, there are mathematical models built from scratch in the form of multicriteria optimization problem; then the goal attainment method of Gembicki is used for reducing the built models to a one-criterion problem of linear programming.

  4. Application of oil spill environmental vulnerability analysis to Brazilian road networks for hazardous cargo transportation; Aplicacao do indice de vulnerabilidade rodoviario para transporte de cargas perigosas

    Energy Technology Data Exchange (ETDEWEB)

    Mattos, M. Beatriz da Costa; Silva Junior, Carlos Leandro da; Almeida, Ana Flavia Oliveira de [Ambipetro Consultoria em Meio Ambiente e Petroleo Ltda., Natal, RN (Brazil)

    2008-07-01

    Roads provide the main means of transportation in Brazil. According to data from the Brazilian Department of Infrastructure and Transport, 96.2% of the passenger transportation and 61.8% of the cargo transportation are based on road infrastructure. However, three quarters of the Brazilian roads are in terrible, unsatisfactory or generally inadequate condition. Poor road conditions are responsible for a great number of accidents with severe consequences for the population and the environment. Given the importance of this matter, there is a need to develop an intelligent system for automatic classification of social and environmental sensitivity maps in order to support actions that respond to emergencies and to help in transportation planning, especially considering the heavy movement of hazardous cargoes such as petroleum and its derivates. For this, tools such as Geographic Information System (GIS) allow social-environmental and traffic engineering characterization maps to be analyzed on a unified, geo referenced digital base. This way, administrators can estimate which stretches of the network are more environmentally sensitive and which pose greater risks, and therefore draw inferences on the most socially and environmentally vulnerable. Social and environmental vulnerability data not only help in the classification of the areas which pose the greater risks, but also make it possible to decide on emergency support points, creating a culture of prevention in the area of hazardous cargo transportation. The case study on the state of Rio Grande do Norte provides a measure of the importance of such work. The city of Natal - the state capital - and the Guamare petrochemical facility are interconnected by 180 Km Road, on which more than 100 tanker trucks loaded with diesel and its derivates travel every day. This road is classified as in poor conditions and, according to the Brazilian Roads Police, it is one of the most dangerous. The relevance of this work is to show

  5. Explosion impacts during transport of hazardous cargo: GIS-based characterization of overpressure impacts and delineation of flammable zones for ammonia.

    Science.gov (United States)

    Inanloo, Bahareh; Tansel, Berrin

    2015-06-01

    The aim of this research was to investigate accidental releases of ammonia followed by an en-route incident in an attempt to further predict the consequences of hazardous cargo accidents. The air dispersion model Areal Locations of Hazardous Atmospheres (ALOHA) was employed to track the probable outcomes of a hazardous material release of a tanker truck under different explosion scenarios. The significance of identification of the flammable zones was taken into consideration; in case the flammable vapor causes an explosion. The impacted areas and the severity of the probable destructions were evaluated for an explosion by considering the overpressure waves. ALOHA in conjunction with ArcGIS was used to delineate the flammable and overpressure impact zones for different scenarios. Based on the results, flammable fumes were formed in oval shapes having a chief axis along the wind direction at the time of release. The expansions of the impact areas under the overpressure value which can lead to property damage for 2 and 20 tons releases, under very stable and unstable atmospheric conditions were estimated to be around 1708, 1206; 3742, 3527 feet, respectively, toward the wind direction. A sensitivity analysis was done to assess the significance of wind speed on the impact zones. The insight provided by this study can be utilized by decision makers in transportation of hazardous materials as a guide for possible rerouting, rescheduling, or limiting the quantity of hazardous cargo to reduce the possible impacts after hazardous cargo accidents during transport.

  6. Design of a smart, survivable sensor system for enhancing the safe and secure transportation of hazardous or high-value cargo on railroads

    Energy Technology Data Exchange (ETDEWEB)

    Hogan, J.R.; Rey, D.; Faas, S.E.

    1994-01-01

    An application of smart sensor technology developed by Sandia National Laboratories for use in the safe and secure transportation of high value of hazardous materials is proposed for a railroad application. The Green Box would be capable of surviving most typical railroad accidents. In an accident, the system would send a distress signal notifying authorities of the location and condition of the cargo; permitting them to respond in the most effective manner. The concept proposes a strap-on sensor package, the Green Box, that could be attached to any railroad car or cargo container. Its primary purpose is to minimize the number, severity and consequences of accidents and to reduce losses due to theft. The system would also be capable of recognizing component failure conditions, notifying the operators and logging sensor data for use in directing preventative maintenance. The modular implementation, which facilitates system integration in a number of applications including the Advanced Train Control System (ACTS), is discussed. The methodology for determining the environmental specification for accident survivability is presented. A test plan for evaluating hardware performance in both normal operating and accident conditions is described.

  7. Cargo transport by several motors

    CERN Document Server

    Zhang, Yunxin

    2010-01-01

    In cells, organelles and vesicles are usually transported by cooperation of several motor proteins, including plus-end directed motor kinesin and minus-end directed motor dynein. Many biophysical models have been constructed to understand the mechanism of this motion. However, so far, the basic principle about it remains unclosed. In this paper, based on the recent experimental results and existing theoretical models, a spider-like model is provided. In this model, each motor is regarded as a bead-spring system. The bead can bind to or unbind from the track stochastically, and step forward or backward with fixed step size L and force dependent transition rates. The spring connects the bead to cargo tightly. At any time, the position of cargo is determined by force balance condition. The obvious characteristics of our model are that, the motors interact with each other and they do not share the external load equally. Our results indicate, the stall force of cargo, under which the mean velocity of cargo vanishe...

  8. Motility states in bidirectional cargo transport

    CERN Document Server

    Klein, Sarah; Santen, Ludger

    2015-01-01

    Intracellular cargos which are transported by molecular motors move stochastically along cytoskeleton filaments. In particular for bidirectionally transported cargos it is an open question whether the characteristics of their motion can result from pure stochastic fluctuations or whether some coordination of the motors is needed. The results of a mean-field model of cargo-motors dynamics, which was proposed by M\\"uller et al.[1] suggest the existence of high motility states which would result from a stochastic tug-of-war. Here we analyze a non-mean field extension of their model, that takes explicitly the position of each motor into account. We find that high motility states then disappear. We consider also a mutual motor-motor activation, as an explicit mechanism of motor coordination. We show that the results of the mean-field model are recovered only in case of a strong motor-motor activation in the limit of a high number of motors.

  9. Fluctuation effects in bidirectional cargo transport

    CERN Document Server

    Klein, Sarah; Santen, Ludger

    2014-01-01

    We discuss a theoretical model for bidirectional cargo transport in biological cells, which is driven by teams of molecular motors and subject to thermal fluctuations. The model describes explicitly the directed motion of the molecular motors on the filament. The motor-cargo coupling is implemented via linear springs. By means of extensive Monte Carlo simulations we show that the model describes the experimentally observed regimes of anomalous diffusion, i.e. subdiffusive behavior at short times followed by superdiffusion at intermediate times. The model results indicate that subdiffuse regime is induced by thermal fluctuations while the superdiffusive motion is generated by correlations of the motors' activity. We also tested the efficiency of bidirectional cargo transport in crowded areas by measuring its ability to pass barriers with increased viscosity. Our results show a remarkable gain of efficiency for high viscosities.

  10. 29 CFR 1917.22 - Hazardous cargo 2 (See § 1917.2(p)).

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 7 2010-07-01 2010-07-01 false Hazardous cargo 2 (See § 1917.2(p)). 1917.22 Section 1917.22 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION... § 1917.2(p)). 2 The Department of Transportation and the United States Coast Guard apply...

  11. Stochastic Movement of Multiple Motor Transported Cargo

    Science.gov (United States)

    Ando, David; Gopinathan, Ajay; Xu, Jing

    2015-03-01

    Experimental observations of cargo position during transport by multiple motors are determined by several coupled stochastic processes. During collective transport, each motor can transition between multiple kinetic states, with the state of each motor influencing the states of the others via mechanical coupling through a common cargo. We measured the motion of a micron sized bead as it is transported by two kinesin motors along a single microtubule track, focusing on cargo displacements which are both axial and transverse to the microtubule. We model the effects of inter-motor interference and the state of each motor throughout time, and back out motor properties using a systematic comparison of experimental observations with simulated model traces over a wide parameter space. Our model captures a surface-associated mode of kinesin, which is only accessible via inter-motor interference in groups, in which kinesin diffuses along the microtubule surface and rapidly ``hops'' between protofilaments without dissociating from the microtubule. This enhances local exploration of the microtubule surface, possibly enabling cellular cargos to overcome macromolecular crowding and to navigate obstacles along micro- tubule tracks without sacrificing overall travel distance.

  12. STRATEGIC MANAGEMENT OF TRANSPORT CARGO COMPLEX

    Directory of Open Access Journals (Sweden)

    A. M. Okorokov

    2014-06-01

    Full Text Available Purpose. Making the qualitative administrative decisions defining strategy and tactics of transport cargo complexes development, and also its subsystems, is possible only in the presence of flexible optimization model. This model has to consider multiparametricity and multicriteriality of the given task, uncertainty and vagueness of input information, and also to provide process automation of searching the best parameters of the given production facility. The purpose of the research is to develop procedures for the strategic management of complex with view of the most important factors and their stochastic nature, which will execute the improvement of technical equipment of TCC. Methodology. The problem of strategic management is based on solving the complex of issues of the optimal number of shunting locomotives, optimal processing capability of handling the front and rational capacity of warehouses. The problem is solved on the basis of the proposed optimality criterion – the specific set of profit per unit of capital assets of freight industry. The listed problems are solved using simulation modeling of the freight industry. Findings. The use of developed procedure allows one to improve the technical equipment of the freight stations and complexes. Originality. For the first time it was developed the procedure of strategic management of development. This procedure allows taking into account the probabilistic nature of demand for services of transport freight complexes and technological processes of client services on the complex stations. The proposed procedure can be applied during when planning the investments in the creation of transport freight complexes. Practical value. Use as a basic tool of simulation models of complex cargo operation allows estimating the effectiveness of the capital investments, the level of operating costs, as well as the quality of meeting the demands of potential customers in transportations at the stage of

  13. NWA Cargo Is Granted Additional Cargo Frequencies to China Four all-cargo frequencies per week granted by U.S. Department of Transportation

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    @@ NWA Cargo, the cargo division of Northwest Airlines, will expand its all-cargo freighter service between the United States and China after being awarded four additional frequencies per week by the U.S. Department of Transportation.

  14. Transporting "exceptional cargo" on the CERN sites

    CERN Multimedia

    EN Department

    2012-01-01

    When the Transport Service is managing "exceptional cargo", the driver and the escort are often in charge of an operation involving equipment worth many hundred thousand francs. Equipment that may well be irreplaceable for a facility or an experiment.   The members of the Transport Service who carry out these tasks are very professional and are – needless to say – highly concentrated on the job. They count on your understanding and support in the traffic on site. Their convoys are – for good reasons – moving slowly. Kindly do not overtake, do not cut in in front of them and do not drive too closely. Respect the escort and do not position yourself between the truck and the escort vehicles. The EN department counts on your courtesy on the road.  

  15. Transportation of hazardous goods

    CERN Multimedia

    TS Department

    2008-01-01

    A general reminder: any transportation of hazardous goods by road is subject to the European ADR rules. The goods concerned are essentially the following: Explosive substances and objects; Gases (including aerosols and non-flammable gases such as helium and nitrogen); Flammable substances and liquids (inks, paints, resins, petroleum products, alcohols, acetone, thinners); Toxic substances (acids, thinners); Radioactive substances; Corrosive substances (paints, acids, caustic products, disinfectants, electrical batteries). Any requests for the transport of hazardous goods must be executed in compliance with the instructions given at this URL: http://ts-dep.web.cern.ch/ts-dep/groups/he/HH/adr.pdf Heavy Handling Section TS-HE-HH 73793 - 160364

  16. Basic mechanisms for recognition and transport of synaptic cargos

    Directory of Open Access Journals (Sweden)

    Schlager Max A

    2009-08-01

    Full Text Available Abstract Synaptic cargo trafficking is essential for synapse formation, function and plasticity. In order to transport synaptic cargo, such as synaptic vesicle precursors, mitochondria, neurotransmitter receptors and signaling proteins to their site of action, neurons make use of molecular motor proteins. These motors operate on the microtubule and actin cytoskeleton and are highly regulated so that different cargos can be transported to distinct synaptic specializations at both pre- and post-synaptic sites. How synaptic cargos achieve specificity, directionality and timing of transport is a developing area of investigation. Recent studies demonstrate that the docking of motors to their cargos is a key control point. Moreover, precise spatial and temporal regulation of motor-cargo interactions is important for transport specificity and cargo recruitment. Local signaling pathways – Ca2+ influx, CaMKII signaling and Rab GTPase activity – regulate motor activity and cargo release at synaptic locations. We discuss here how different motors recognize their synaptic cargo and how motor-cargo interactions are regulated by neuronal activity.

  17. Cargo transportation by two species of motor protein.

    Science.gov (United States)

    Zhang, Yunxin

    2013-05-01

    The cargo motion in living cells transported by two species of motor protein with different intrinsic directionalities is discussed in this study. Similarly to single motor movement, the cargo steps forward and backward along a microtubule stochastically. Recent experiments found that cargo transportation by two motor species has a memory; it does not change its direction as frequently as expected, which means that its forward and backward step rates depend on its previous motion trajectory. By assuming that the cargo has only the least possible memory, i.e., its step direction depends only on the direction of its last step, two cases of cargo motion are analyzed in detail in this study: (I) cargo motion under constant external load, and (II) cargo motion in one fixed optical trap. Due to the existence of memory, in the first case, the cargo can keep moving in the same direction for a long distance. In the second case, the cargo will oscillate in the trap. The oscillation period decreases and the oscillation amplitude increases with increasing forward step rate of the motor, but both of them decrease with increasing trap stiffness. The most likely location of the cargo, where the probability of finding the oscillating cargo is maximum, may be the same as or may be different from the trap center, which depends on the step rates of the two motor species. Meanwhile, if the motors are robust, i.e., their forward to backward step rate ratios are high, there may be two such most likely locations, located one on each side of the trap center. The probability of finding the cargo in a given location, the probability of the cargo being in forward or backward motion, and various mean first passage times of the cargo to a given location or a given state are also analyzed.

  18. Cargo transportation by two species of motor protein

    CERN Document Server

    Zhang, Yunxin

    2012-01-01

    The cargo motion in living cells transported by two species of motor protein with different intrinsic directionality is discussed in this study. Similar to single motor movement, cargo steps forward and backward along microtubule stochastically. Recent experiments found that, cargo transportation by two motor species has a memory, it does not change its direction as frequently as expected, which means that its forward and backward step rates depends on its previous motion trajectory. By assuming cargo has only the least memory, i.e. its step direction depends only on the direction of its last step, two cases of cargo motion are detailed analyzed in this study: {\\bf (I)} cargo motion under constant external load; and {\\bf (II)} cargo motion in one fixed optical trap. Due to the existence of memory, for the first case, cargo can keep moving in the same direction for a long distance. For the second case, the cargo will oscillate in the trap. The oscillation period decreases and the oscillation amplitude increase...

  19. Air Cargo Transportation Route Choice Analysis

    Science.gov (United States)

    Obashi, Hiroshi; Kim, Tae-Seung; Oum, Tae Hoon

    2003-01-01

    Using a unique feature of air cargo transshipment data in the Northeast Asian region, this paper identifies the critical factors that determine the transshipment route choice. Taking advantage of the variations in the transport characteristics in each origin-destination airports pair, the paper uses a discrete choice model to describe the transshipping route choice decision made by an agent (i.e., freight forwarder, consolidator, and large shipper). The analysis incorporates two major factors, monetary cost (such as line-haul cost and landing fee) and time cost (i.e., aircraft turnaround time, including loading and unloading time, custom clearance time, and expected scheduled delay), along with other controls. The estimation method considers the presence of unobserved attributes, and corrects for resulting endogeneity by use of appropriate instrumental variables. Estimation results find that transshipment volumes are more sensitive to time cost, and that the reduction in aircraft turnaround time by 1 hour would be worth the increase in airport charges by more than $1000. Simulation exercises measures the impacts of alternative policy scenarios for a Korean airport, which has recently declared their intention to be a future regional hub in the Northeast Asian region. The results suggest that reducing aircraft turnaround time at the airport be an effective strategy, rather than subsidizing to reduce airport charges.

  20. Modern approaches to cargo protection of rail transportation

    Directory of Open Access Journals (Sweden)

    Денис Викторович Ломотько

    2014-12-01

    Full Text Available On the basis of the study we have proposed a number of measures to improve the cargo protection during rail transportation. The economic impact of some of them is estimated. The legal relations of railways and cargo owners in terms of liability for failure to preserve are considered and proposed the management model of insurance risks of failure to preserve in transportation.

  1. Environmental control of microtubule-based bidirectional cargo-transport

    CERN Document Server

    Klein, Sarah; Santen, Ludger

    2014-01-01

    Inside cells, various cargos are transported by teams of molecular motors. Intriguingly, the motors involved generally have opposite pulling directions, and the resulting cargo dynamics is a biased stochastic motion. It is an open question how the cell can control this bias. Here we develop a model which takes explicitly into account the elastic coupling of the cargo with each motor. We show that bias can be simply controlled or even reversed in a counterintuitive manner via a change in the external force exerted on the cargo or a variation of the ATP binding rate to motors. Furthermore, the superdiffusive behavior found at short time scales indicates the emergence of motor cooperation induced by cargo-mediated coupling.

  2. Environmental control of microtubule-based bidirectional cargo transport

    Science.gov (United States)

    Klein, Sarah; Appert-Rolland, Cécile; Santen, Ludger

    2014-07-01

    Inside cells, various cargos are transported by teams of molecular motors. Intriguingly, the motors involved generally have opposite pulling directions, and the resulting cargo dynamics is a biased stochastic motion. It is an open question how the cell can control this bias. Here we develop a model which takes explicitly into account the elastic coupling of the cargo with each motor. We show that bias can be simply controlled or even reversed in a counterintuitive manner via a change in the external force exerted on the cargo or a variation of the environmental properties. Furthermore, the superdiffusive behavior found at short time scales indicates the emergence of motor cooperation induced by cargo-mediated coupling.

  3. Cooperative behavior of molecular motors: Cargo transport and traffic phenomena

    Science.gov (United States)

    Lipowsky, Reinhard; Beeg, Janina; Dimova, Rumiana; Klumpp, Stefan; Müller, Melanie J. I.

    2010-01-01

    All eukaryotic cells including those of our own body contain complex transport systems based on molecular motors which walk along cytoskeletal filaments. These motors are rather small and make discrete mechanical steps with a step size of the order of 10 nm but are able to pull cargo particles over much larger distances, from micrometers up to meters. In vivo, the intracellular cargos include large membrane-bounded organelles, smaller vesicles, a subset of mRNAs, cytoskeletal filaments, and various protein building blocks, which are transported between different cell compartments. This cargo transport is usually performed by teams of motors. If all motors belong to the same molecular species, the cooperative action of the motors leads to uni-directional transport with a strongly increased run length and with a characteristic force dependence of the velocity distributions. If two antagonistic teams of motors pull on the same cargo particle, they perform a stochastic tug-of-war, which is characterized by a subtle force balance between the two motor teams and leads to several distinct patterns of bi-directional transport. So far, all experimental observations on bi-directional transport are consistent with such a tug-of-war. If many motors and/or cargo particles are transported along the filaments, one encounters various traffic phenomena. Depending on their mutual interactions and the compartment geometry, the motors form various spatio-temporal patterns such as traffic jams, and undergo nonequilibrium phase transitions between different patterns of transport.

  4. Anomalous motor mediated cargo transport in microtubule networks

    Science.gov (United States)

    Vandal, Steven; Macveigh-Fierro, Daniel; Shen, Zhiyuan; Lemoi, Kyle; Vidali, Luis; Ross, Jennifer; Tuzel, Erkan

    Cargo transport is an important biological mechanism by which cells locomote, self-organize, and actively transport organelles. This transport is mediated by the cytoskeletal network and molecular motors; however, it is not known how network self-organization and dynamics affect these transport processes. In order to develop a mechanistic understanding of cargo transport, we use a coarse-grained Brownian dynamics model that incorporates the dynamics of these networks, as well as experimentally determined motor properties. We will test these models with two experimental systems: (1) in vitro microtubule networks with kinesin-1 motors, and quantum dot cargos on recreated microtubule networks, and (2) an excellent model organism, the moss Physcomitrella patens, in which chloroplasts are transported via the microtubule network by means of kinesin-like proteins. Phenomenological network characterizations are made, both in vivo and in vitro, and cargo motility is characterized using Mean Squared Displacement (MSD) measurements. Our simulations shed light on the role of network density and motor properties on the observed transport behavior, and improve our understanding of cargo transport in cells.

  5. Bidirectionality From Cargo Thermal Fluctuations in Motor-Mediated Transport

    CERN Document Server

    Miles, Christopher E

    2016-01-01

    Molecular motor proteins serve as an essential component of intracellular transport by generating forces to haul cargoes along cytoskeletal filaments. In some circumstances, two species of motors that are directed oppositely (e.g. kinesin, dynein) can be attached to the same cargo. The resulting net motion is known to be bidirectional, but the mechanism of switching remains unclear. In this work, we propose a mean-field mathematical model of the mechanical interactions of two populations of molecular motors with diffusion of the cargo (thermal fluctuations) as the fundamental noise source. By studying a simplified model, the delayed response of motors to rapid fluctuations in the cargo is quantified, allowing for the reduction of the full model to two "characteristic positions" of each of the motor populations. The system is then found to be "metastable", switching between two distinct directional transport states, or bidirectional motion. The time to switch between these states is then investigated using WKB...

  6. 19 CFR 122.117 - Requirements for transit air cargo transport.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Requirements for transit air cargo transport. 122... Requirements for transit air cargo transport. (a) Transportation—(1) Port to port. Transit air cargo may be... cargo, a receipt shall be given. The receipt shall be made by the airline responsible for transport...

  7. Shared Value Potential of Transporting Cargo via Hyperloop

    Directory of Open Access Journals (Sweden)

    Max Werner

    2016-08-01

    Full Text Available This research estimates the shared value created by constructing a hypothetical Hyperloop to transport cargo along 300 km in Northern Germany. Following Porter-Kramer (2011, we identified and evaluated eight factors that create shared value: travel speed, operating costs, safety, noise pollution, air pollution, climate effect/carbon footprint, separation effect/ property efficiency, and maintenance. Using official data compiled by several German institutes and organizations, we conducted comparative analysis to quantify and compare the abovementioned factors for Hyperloop and over-the-road cargo transport in Germany. Then, we monetized the individual and collective benefits of the shared value created by Hyperloop replacing a significant share of cargo transported by truck. Our findings indicate that the hypothetical Hyperloop project in Northern Germany would create €660 to €900 million of shared value annually. Our research method establishes a framework for assessing future transportation projects like Hyperloop, and our findings can be generalized to industrialized nations beyond Germany.

  8. Coupling of Active Motion and Advection Shapes Intracellular Cargo Transport

    CERN Document Server

    Trong, P Khuc; Goldstein, R E; 10.1103/PhysRevLett.109.028104

    2012-01-01

    Intracellular cargo transport can arise from passive diffusion, active motor-driven transport along cytoskeletal filament networks, and passive advection by fluid flows entrained by such motor/cargo motion. Active and advective transport are thus intrinsically coupled as related, yet different representations of the same underlying network structure. A reaction-advection-diffusion system is used here to show that this coupling affects the transport and localization of a passive tracer in a confined geometry. For sufficiently low diffusion, cargo localization to a target zone is optimized either by low reaction kinetics and decoupling of bound and unbound states, or by a mostly disordered cytoskeletal network with only weak directional bias. These generic results may help to rationalize subtle features of cytoskeletal networks, for example as observed for microtubules in fly oocytes.

  9. Stochastic modeling of cargo transport by teams of molecular motors

    CERN Document Server

    Klein, Sarah; Santen, Ludger

    2014-01-01

    Many different types of cellular cargos are transported bidirectionally along microtubules by teams of molecular motors. The motion of this cargo-motors system has been experimentally characterized in vivo as processive with rather persistent directionality. Different theoretical approaches have been suggested in order to explore the origin of this kind of motion. An effective theoretical approach, introduced by M\\"uller et al., describes the cargo dynamics as a tug-of-war between different kinds of motors. An alternative approach has been suggested recently by Kunwar et al., who considered the coupling between motor and cargo in more detail. Based on this framework we introduce a model considering single motor positions which we propagate in continuous time. Furthermore, we analyze the possible influence of the discrete time update schemes used in previous publications on the system's dynamic.

  10. A consolidation model for cargo-driven intermodal transportation

    NARCIS (Netherlands)

    Behdani, B.; Zuidwijk, R.A.

    2014-01-01

    Accessibility of main sea ports by road has become increasingly difficult due to rapid growth in container throughput. To deal with this challenge, new ways for handling containers and distribution of cargo flows are needed to define and implement. One possibility is going beyond container transport

  11. Logistics in the cell: cargoes and transportation.

    Science.gov (United States)

    Nadezhdina, E S

    2014-09-01

    Eukaryotic cells are large and thus require a vesicular transport system. The system involves the formation of membrane transport containers, their short- and long-distance movements, recognition of destination points, and fusion with other membranes. Understanding the molecular mechanisms of these processes is of theoretical and practical significance. This special issue of Biochemistry (Moscow) collects surveys and experimental articles describing various aspects of vesicular transport.

  12. 33 CFR 401.69 - Hazardous cargo vessels.

    Science.gov (United States)

    2010-07-01

    ... bulk, having a flashpoint below 61 °C, including a tanker that is not gas free where its previous cargo had a flashpoint below 61 °C; (b) A tanker carrying compressed liquefied gases, bulk acids or liquefied chamicals; (1) In excess of 50 tonnes of gases, compressed, liquified or dissolved under pressure...

  13. Transportation of Hazardous Evidentiary Material.

    Energy Technology Data Exchange (ETDEWEB)

    Osborn, Douglas.

    2005-06-01

    This document describes the specimen and transportation containers currently available for use with hazardous and infectious materials. A detailed comparison of advantages, disadvantages, and costs of the different technologies is included. Short- and long-term recommendations are also provided.3 DraftDraftDraftExecutive SummaryThe Federal Bureau of Investigation's Hazardous Materials Response Unit currently has hazardous material transport containers for shipping 1-quart paint cans and small amounts of contaminated forensic evidence, but the containers may not be able to maintain their integrity under accident conditions or for some types of hazardous materials. This report provides guidance and recommendations on the availability of packages for the safe and secure transport of evidence consisting of or contaminated with hazardous chemicals or infectious materials. Only non-bulk containers were considered because these are appropriate for transport on small aircraft. This report will addresses packaging and transportation concerns for Hazardous Classes 3, 4, 5, 6, 8, and 9 materials. If the evidence is known or suspected of belonging to one of these Hazardous Classes, it must be packaged in accordance with the provisions of 49 CFR Part 173. The anthrax scare of several years ago, and less well publicized incidents involving unknown and uncharacterized substances, has required that suspicious substances be sent to appropriate analytical laboratories for analysis and characterization. Transportation of potentially hazardous or infectious material to an appropriate analytical laboratory requires transport containers that maintain both the biological and chemical integrity of the substance in question. As a rule, only relatively small quantities will be available for analysis. Appropriate transportation packaging is needed that will maintain the integrity of the substance, will not allow biological alteration, will not react chemically with the substance being

  14. Vacuolar transport in tobacco leaf epidermis cells involves a single route for soluble cargo and multiple routes for membrane cargo.

    Science.gov (United States)

    Bottanelli, Francesca; Foresti, Ombretta; Hanton, Sally; Denecke, Jürgen

    2011-08-01

    We tested if different classes of vacuolar cargo reach the vacuole via distinct mechanisms by interference at multiple steps along the transport route. We show that nucleotide-free mutants of low molecular weight GTPases, including Rab11, the Rab5 members Rha1 and Ara6, and the tonoplast-resident Rab7, caused induced secretion of both lytic and storage vacuolar cargo. In situ analysis in leaf epidermis cells indicates a sequential action of Rab11, Rab5, and Rab7 GTPases. Compared with Rab5 members, mutant Rab11 mediates an early transport defect interfering with the arrival of cargo at prevacuoles, while mutant Rab7 inhibits the final delivery to the vacuole and increases cargo levels in prevacuoles. In contrast with soluble cargo, membrane cargo may follow different routes. Tonoplast targeting of an α-TIP chimera was impaired by nucleotide-free Rha1, Ara6, and Rab7 similar to soluble cargo. By contrast, the tail-anchored tonoplast SNARE Vam3 shares only the Rab7-mediated vacuolar deposition step. The most marked difference was observed for the calcineurin binding protein CBL6, which was insensitive to all Rab mutants tested. Unlike soluble cargo, α-TIP and Vam3, CBL6 transport to the vacuole was COPII independent. The results indicate that soluble vacuolar proteins follow a single route to vacuoles, while membrane spanning proteins may use at least three different transport mechanisms.

  15. Transportation of Hazardous Materials Emergency Preparedness Hazards Assessment

    Energy Technology Data Exchange (ETDEWEB)

    Blanchard, A.

    2000-02-28

    This report documents the Emergency Preparedness Hazards Assessment (EPHA) for the Transportation of Hazardous Materials (THM) at the Department of Energy (DOE) Savannah River Site (SRS). This hazards assessment is intended to identify and analyze those transportation hazards significant enough to warrant consideration in the SRS Emergency Management Program.

  16. Shared Value Potential of Transporting Cargo via Hyperloop

    OpenAIRE

    Max Werner; Klaus Eissing; Sebastian Langton

    2016-01-01

    This research estimates the shared value created by constructing a hypothetical Hyperloop to transport cargo along 300 km in Northern Germany. Following Porter-Kramer (2011), we identified and evaluated eight factors that create shared value: travel speed, operating costs, safety, noise pollution, air pollution, climate effect/carbon footprint, separation effect/ property efficiency, and maintenance. Using official data compiled by several German institutes and organizations, we conducted com...

  17. Shared value potential of transporting cargo via hyperloop

    OpenAIRE

    Max Werner; Klaus Eissing; Sebastian Langton

    2016-01-01

    This research estimates the shared value created by constructing a hypothetical Hyperloop to transport cargo along 300 km in Northern Germany. Following Porter and Kramer (2011, 2012), we identified and evaluated eight factors that create shared value: travel speed, operating costs, safety, noise pollution, air pollution, climate effect/carbon footprint, separation effect/property efficiency, and maintenance. Using official data compiled by several German institutes and organizations, we cond...

  18. 49 CFR 173.33 - Hazardous materials in cargo tank motor vehicles.

    Science.gov (United States)

    2010-10-01

    ... is marked and used exclusively to transport carbon dioxide, or except when an MC 338 is used to transport argon, carbon dioxide, helium, krypton, neon, nitrogen, and xenon. However, if the cargo tank... that provides the venting capacity prescribed in § 178.345-10(e) of this subchapter. The...

  19. Safety evaluation for packaging transport of LSA-II liquids in MC-312 cargo tanks

    Energy Technology Data Exchange (ETDEWEB)

    Carlstrom, R.F.

    1996-09-11

    This safety evaluation for packaging authorizes the onsite transfer of bulk LSA-II radioactive liquids in the 222-S Laboratory Cargo Tank and Liquid Effluent Treatment Facility Cargo Tanks (which are U.S. Department of Transportation MC-312 specification cargo tanks) from their operating facilities to tank farm facilities.

  20. Safety of Oversize Cargo in Ports and in the Sea Transport

    Directory of Open Access Journals (Sweden)

    Miroslaw Chmielinski

    2017-03-01

    Full Text Available Author of the paper analyzes problems related to the safety of the oversize cargo in ports and in the sea transport. Various modes of transport are used to carry oversized units that often include maritime transport. Transport of oversized cargo includes non-standard large and heavy pieces of cargo, such as electric transformers, reactor vessels, wind turbines, airplane fuselage or nuclear power plant components. The above paper is based on results of research oversized cargo in the Elpo Service Company and Pol-Mare Ltd. forwarding consulting agency.

  1. Co-operative versus independent transport of different cargoes by Kinesin-1.

    Science.gov (United States)

    Hammond, Jennetta W; Griffin, Kelly; Jih, Gloria T; Stuckey, Jeanne; Verhey, Kristen J

    2008-05-01

    Kinesin motors drive the intracellular transport of multiple cargoes along microtubule tracks; yet, how kinesins discriminate among their many potential cargoes is unknown. We tested whether Kinesin-1 cargoes compete, co-operate or are transported independently of each other. We focused on Kinesin-1 cargoes that bind directly to the kinesin light chain (KLC) subunit, namely the c-Jun NH(2)-terminal kinase-interacting proteins (JIPs) 1 and 3, Kidins220/ARMS and PAT1. Overexpression of individual cargo proteins in differentiated CAD cells resulted in mislocalization of the endogenous protein but had no effect on localization of other cargo proteins to neurite tips. Thus, while transport of distinct cargoes is saturable, they do not compete with each other. Interestingly, we found that low expression of JIP1 or JIP3 enhanced the transport of the other JIP to neurite tips. Moreover, JIP1 and JIP3 require each other for transport. Co-operative transport is due to an interaction between JIP1 and JIP3 as well as distinct binding sites on the KLC tetratricopeptide repeat (TPR) bundle: the TPR groove binds to C-terminal residues of JIP1, whereas the TPR surface binds to internal residues in JIP3. Formation of a JIP1/JIP3/KLC complex is necessary for efficient JIP1 or JIP3 transport in neuronal cells. Thus, JIP scaffolding proteins are transported in a co-operative manner, despite the independent transport of other Kinesin-1 cargoes.

  2. Hazardous Material Packaging and Transportation

    Energy Technology Data Exchange (ETDEWEB)

    Hypes, Philip A. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-02-04

    This is a student training course. Some course objectives are to: recognize and use standard international and US customary units to describe activities and exposure rates associated with radioactive material; determine whether a quantity of a single radionuclide meets the definition of a class 7 (radioactive) material; determine, for a given single radionuclide, the shipping quantity activity limits per 49 Code of Federal Regulations (CFR) 173.435; determine the appropriate radioactive material hazard class proper shipping name for a given material; determine when a single radionuclide meets the DOT definition of a hazardous substance; determine the appropriate packaging required for a given radioactive material; identify the markings to be placed on a package of radioactive material; determine the label(s) to apply to a given radioactive material package; identify the entry requirements for radioactive material labels; determine the proper placement for radioactive material label(s); identify the shipping paper entry requirements for radioactive material; select the appropriate placards for a given radioactive material shipment or vehicle load; and identify allowable transport limits and unacceptable transport conditions for radioactive material.

  3. Effect of fuel concentration on cargo transport by a team of Kinesin motors

    Science.gov (United States)

    Takshak, Anjneya; Mishra, Nirvantosh; Kulkarni, Aditi; Kunwar, Ambarish

    2017-02-01

    Eukaryotic cells employ specialized proteins called molecular motors for transporting organelles and vesicles from one location to another in a regulated and directed manner. These molecular motors often work collectively in a team while transporting cargos. Molecular motors use cytoplasmic ATP as fuel, which is hydrolyzed to generate mechanical force. While the effect of ATP concentration on cargo transport by single Kinesin motor function is well understood, it is still unexplored, both theoretically and experimentally, how ATP concentration would affect cargo transport by a team of Kinesin motors. For instance, how does fuel concentration affect the travel distances and travel velocities of cargo? How cooperativity of Kinesin motors engaged on a cargo is affected by ATP concentration? To answer these questions, here we develop mechano-chemical models of cargo transport by a team of Kinesin motors. To develop these models we use experimentally-constrained mechano-chemical model of a single Kinesin motor as well as earlier developed mean-field and stochastic models of load sharing for cargo transport. Thus, our new models for cargo transport by a team of Kinesin motors include fuel concentration explicitly, which was not considered in earlier models. We make several interesting predictions which can be tested experimentally. For instance, the travel distances of cargos are very large at limited ATP concentrations in spite of very small travel velocity. Velocities of cargos driven by multiple Kinesin have a Michaelis-Menten dependence on ATP concentration. Similarly, cooperativity among the engaged Kinesin motors on the cargo shows a Michaelis-Menten type dependence, which attains a maximum value near physiological ATP concentrations. Our new results can be potentially useful in controlling artificial nano-molecular shuttles precisely for targeted delivery in various nano-technological applications.

  4. Stochastic simulations of cargo transport by processive molecular motors.

    Science.gov (United States)

    Korn, Christian B; Klumpp, Stefan; Lipowsky, Reinhard; Schwarz, Ulrich S

    2009-12-28

    We use stochastic computer simulations to study the transport of a spherical cargo particle along a microtubule-like track on a planar substrate by several kinesin-like processive motors. Our newly developed adhesive motor dynamics algorithm combines the numerical integration of a Langevin equation for the motion of a sphere with kinetic rules for the molecular motors. The Langevin part includes diffusive motion, the action of the pulling motors, and hydrodynamic interactions between sphere and wall. The kinetic rules for the motors include binding to and unbinding from the filament as well as active motor steps. We find that the simulated mean transport length increases exponentially with the number of bound motors, in good agreement with earlier results. The number of motors in binding range to the motor track fluctuates in time with a Poissonian distribution, both for springs and cables being used as models for the linker mechanics. Cooperativity in the sense of equal load sharing only occurs for high values for viscosity and attachment time.

  5. Cargo Fire Hazards and Hazard Control for the Offshore Bulk Fuel Systems (OBFS).

    Science.gov (United States)

    1980-06-01

    Unclassified SeCURITY CLASIF ~ICATION all THIS PAGE rth-u.. MS en..dj I. OnSI um tlaVESfe A Af .f Imd S AIC CESSIO No. 11H. 019Cfeil’ CAZ0 FU1al IS. TYPE...regular protein foam could be made prior to detail specification of the foam system equipment. The cargo transfer area (between the machinery area and... protein foam with the proper proportioning orifice installed in the ratio-flow proportioner. National also advises that a proportioning system for AFFF

  6. How molecular motors are arranged on a cargo is important for vesicular transport.

    Science.gov (United States)

    Erickson, Robert P; Jia, Zhiyuan; Gross, Steven P; Yu, Clare C

    2011-05-01

    The spatial organization of the cell depends upon intracellular trafficking of cargos hauled along microtubules and actin filaments by the molecular motor proteins kinesin, dynein, and myosin. Although much is known about how single motors function, there is significant evidence that cargos in vivo are carried by multiple motors. While some aspects of multiple motor function have received attention, how the cargo itself--and motor organization on the cargo--affects transport has not been considered. To address this, we have developed a three-dimensional Monte Carlo simulation of motors transporting a spherical cargo, subject to thermal fluctuations that produce both rotational and translational diffusion. We found that these fluctuations could exert a load on the motor(s), significantly decreasing the mean travel distance and velocity of large cargos, especially at large viscosities. In addition, the presence of the cargo could dramatically help the motor to bind productively to the microtubule: the relatively slow translational and rotational diffusion of moderately sized cargos gave the motors ample opportunity to bind to a microtubule before the motor/cargo ensemble diffuses out of range of that microtubule. For rapidly diffusing cargos, the probability of their binding to a microtubule was high if there were nearby microtubules that they could easily reach by translational diffusion. Our simulations found that one reason why motors may be approximately 100 nm long is to improve their 'on' rates when attached to comparably sized cargos. Finally, our results suggested that to efficiently regulate the number of active motors, motors should be clustered together rather than spread randomly over the surface of the cargo. While our simulation uses the specific parameters for kinesin, these effects result from generic properties of the motors, cargos, and filaments, so they should apply to other motors as well.

  7. How molecular motors are arranged on a cargo is important for vesicular transport.

    Directory of Open Access Journals (Sweden)

    Robert P Erickson

    2011-05-01

    Full Text Available The spatial organization of the cell depends upon intracellular trafficking of cargos hauled along microtubules and actin filaments by the molecular motor proteins kinesin, dynein, and myosin. Although much is known about how single motors function, there is significant evidence that cargos in vivo are carried by multiple motors. While some aspects of multiple motor function have received attention, how the cargo itself--and motor organization on the cargo--affects transport has not been considered. To address this, we have developed a three-dimensional Monte Carlo simulation of motors transporting a spherical cargo, subject to thermal fluctuations that produce both rotational and translational diffusion. We found that these fluctuations could exert a load on the motor(s, significantly decreasing the mean travel distance and velocity of large cargos, especially at large viscosities. In addition, the presence of the cargo could dramatically help the motor to bind productively to the microtubule: the relatively slow translational and rotational diffusion of moderately sized cargos gave the motors ample opportunity to bind to a microtubule before the motor/cargo ensemble diffuses out of range of that microtubule. For rapidly diffusing cargos, the probability of their binding to a microtubule was high if there were nearby microtubules that they could easily reach by translational diffusion. Our simulations found that one reason why motors may be approximately 100 nm long is to improve their 'on' rates when attached to comparably sized cargos. Finally, our results suggested that to efficiently regulate the number of active motors, motors should be clustered together rather than spread randomly over the surface of the cargo. While our simulation uses the specific parameters for kinesin, these effects result from generic properties of the motors, cargos, and filaments, so they should apply to other motors as well.

  8. 75 FR 42364 - Hazardous Materials: Incorporation of Certain Cargo Tank Special Permits Into Regulations

    Science.gov (United States)

    2010-07-21

    .... Congress expressly authorized DOT to issue these variances in the Hazardous Materials Transportation Act of... dissolving into the water as ammonium hydroxide while simultaneously boiling into the atmosphere as gaseous...

  9. Neutron and Photon Transport in Sea-Going Cargo Containers

    Energy Technology Data Exchange (ETDEWEB)

    Pruet, J; Descalle, M; Hall, J; Pohl, B; Prussin, S G

    2005-02-09

    Factors affecting sensing of small quantities of fissionable material in large sea-going cargo containers by neutron interrogation and detection of {beta}-delayed photons are explored. The propagation of variable-energy neutrons in cargos, subsequent fission of hidden nuclear material and production of the {beta}-delayed photons, and the propagation of these photons to an external detector are considered explicitly. Detailed results of Monte Carlo simulations of these stages in representative cargos are presented. Analytical models are developed both as a basis for a quantitative understanding of the interrogation process and as a tool to allow ready extrapolation of the results to cases not specifically considered here.

  10. Cargo Loading Facilities, Published in unknown, Arizona Department of Transportation.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Cargo Loading Facilities dataset as of unknown. Data by this publisher are often provided in State Plane coordinate system; in a Transverse Mercator projection;...

  11. Cargo-towing synthetic nanomachines: towards active transport in microchip devices.

    Science.gov (United States)

    Wang, Joseph

    2012-05-08

    This review article discusses the use of synthetic catalytic nano motors for cargo manipulations and for developing miniaturized lab-on-chip systems based on autonomous transport. The ability of using chemically-powered artificial nanomotors to capture, transport and release therapeutic payloads or nanostructured biomaterials represents one of the next major prospects for nanomotor development. The increased cargo-towing force of such self-propelled nanomotors, along with their precise motion control within microchannel networks, versatility and facile functionalization, pave the way to new integrated functional lab-on-a-chip powered by active transport and perform a series of tasks. Such use of cargo-towing artificial nanomotors has been inspired by on-chip kinesin molecular shuttles. Functionalized nano/microscale motors can thus be used to pick a selected nano/microscale chemical or biological payload target at the right place, transport and deliver them to a target location in a timely manner. Key challenges for using synthetic nanomachines for driving transport processes along microchannel networks are discussed, including loading and unloading of cargo and precise motion control, along with recent examples of related cargo manipulation processes and guided transport in lab-on-a-chip formats. The exciting research area of cargo-carrying catalytic man-made nanomachines is expected to grow rapidly, to lead to new lab-on-a-chip formats and to provide a wide range of future microchip opportunities.

  12. External forces influence the elastic coupling effects during cargo transport by molecular motors.

    Science.gov (United States)

    Berger, Florian; Keller, Corina; Klumpp, Stefan; Lipowsky, Reinhard

    2015-02-01

    Cellular transport is achieved by the cooperative action of molecular motors which are elastically linked to a common cargo. When the motors pull on the cargo at the same time, they experience fluctuating elastic strain forces induced by the stepping of the other motors. These elastic coupling forces can influence the motors' stepping and unbinding behavior and thereby the ability to transport cargos. Based on a generic single motor description, we introduce a framework that explains the response of two identical molecular motors to a constant external force. In particular, we relate the single motor parameters, the coupling strength and the external load force to the dynamics of the motor pair. We derive four distinct transport regimes and determine how the crossover lines between the regimes depend on the load force. Our description of the overall cargo dynamics takes into account relaxational displacements of the cargo caused by the unbinding of one motor. For large forces and weak elastic coupling these back-shifts dominate the displacements. To develop an intuitive understanding about motor cooperativity during cargo transport, we introduce a time scale for load sharing. This time scale allows us to predict how the regulation of single motor parameters influences the cooperativity. As an example, we show that up-regulating the single motor processivity enhances load sharing of the motor pair.

  13. A propagating ATPase gradient drives transport of surface-confined cellular cargo.

    Science.gov (United States)

    Vecchiarelli, Anthony G; Neuman, Keir C; Mizuuchi, Kiyoshi

    2014-04-01

    The faithful segregation of duplicated genetic material into daughter cells is critical to all organisms. In many bacteria, the segregation of chromosomes involves transport of "centromere-like" loci over the main body of the chromosome, the nucleoid, mediated by a two-protein partition system: a nonspecific DNA-binding ATPase, ParA, and an ATPase stimulator, ParB, which binds to the centromere-like loci. These systems have previously been proposed to function through a filament-based mechanism, analogous to actin- or microtubule-based movement. Here, we reconstituted the F-plasmid partition system using a DNA-carpeted flow cell as an artificial nucleoid surface and magnetic beads coated with plasmid partition complexes as surface-confined cargo. This minimal system recapitulated directed cargo motion driven by a surface ATPase gradient that propagated with the cargo. The dynamics are consistent with a diffusion-ratchet model, whereby the cargo dynamically establishes, and interacts with, a concentration gradient of the ATPase. A chemophoresis force ensues as the cargo perpetually chases the ATPase gradient, allowing the cargo to essentially "surf" the nucleoid on a continuously traveling wave of the ATPase. Demonstration of this non-filament-based motility mechanism in a biological context establishes a distinct class of motor system used for the transport and positioning of large cellular cargo.

  14. 46 CFR 151.50-5 - Cargoes having toxic properties.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Cargoes having toxic properties. 151.50-5 Section 151.50... BARGES CARRYING BULK LIQUID HAZARDOUS MATERIAL CARGOES Special Requirements § 151.50-5 Cargoes having... transporting liquids having a Reid vapor pressure exceeding 14 pounds per square inch absolute or vented at...

  15. Cargo transport by cytoplasmic Dynein can center embryonic centrosomes.

    Directory of Open Access Journals (Sweden)

    Rafael A Longoria

    Full Text Available To complete meiosis II in animal cells, the male DNA material needs to meet the female DNA material contained in the female pronucleus at the egg center, but it is not known how the male pronucleus, deposited by the sperm at the periphery of the cell, finds the cell center in large eggs. Pronucleus centering is an active process that appears to involve microtubules and molecular motors. For small and medium-sized cells, the force required to move the centrosome can arise from either microtubule pushing on the cortex, or cortically-attached dynein pulling on microtubules. However, in large cells, such as the fertilized Xenopus laevis embryo, where microtubules are too long to support pushing forces or they do not reach all boundaries before centrosome centering begins, a different force generating mechanism must exist. Here, we present a centrosome positioning model in which the cytosolic drag experienced by cargoes hauled by cytoplasmic dynein on the sperm aster microtubules can move the centrosome towards the cell's center. We find that small, fast cargoes (diameter ∼100 nm, cargo velocity ∼2 µm/s are sufficient to move the centrosome in the geometry of the Xenopus laevis embryo within the experimentally observed length and time scales.

  16. Bidirectional transport of motor-driven cargoes in cell: A random walk with memory

    Science.gov (United States)

    Bhat, Deepak; Gopalakrishnan, Manoj

    2013-02-01

    Motor-driven bidirectional transport inside a cell is an intriguing phenomenon where multiple dyneins and kinesins drag cargoes and deliver them to specific locations. Quite often, both anterograde (plus) and retrograde (minus) directed motors reside simultaneously on the cargo and co-ordinate their activity such that the motion of the cargo looks like spells of plus directed and minus directed segments, with pauses in between. The stochastic tug-of-war model is widely used to analyze this motion, largely studied by computer simulations. Here, we present some analytical results for this model, such as the average durations of plus and minus-run segments and tug-of-war events as well as probabilities of persistence and reversal of directions following a tug-of-war. We show that cargo motion has memory in case of 2 dyneins and 1 kinesin driving together, while it is absent when only a dynein and a kinesin is involved.

  17. Detection of explosives, shielded nuclear materials and other hazardous substances in cargo containers

    Science.gov (United States)

    Kuznetsov, Andrey; Evsenin, Alexey; Vakhtin, Dmitry; Gorshkov, Igor; Osetrov, Oleg; Kalinin, Valery

    2006-05-01

    Nanosecond Neutron Analysis / Associated Particles Technique (NNA/APT) has been used to create devices for detection of explosives, radioactive and heavily shielded nuclear materials in cargo containers. Explosives and other hazardous materials are detected by analyzing secondary high-energy gamma-rays form reactions of fast neutrons with the materials inside the container. Depending on the dimensions of the inspected containers, the detecting system consists of one or several detection modules, each of which contains a small neutron generator with built-in position sensitive detector of associated alpha-particles and several scintillator-based gamma-ray detectors. The same gamma-ray detectors are used to detect unshielded radioactive and nuclear materials. Array of several detectors of fast neutrons is used to detect neutrons from spontaneous and induced fission of nuclear materials. These neutrons can penetrate thick layers of lead shielding, which can be used to conceal gamma-radioactivity from nuclear materials. Coincidence and timing analysis allows one to discriminate between fission neutrons and scattered probing neutrons. Mathematical modeling by MCNP5 code was used to estimate the sensitivity of the device and its optimal configuration. Capability of the device to detect 1 kg of explosive imitator inside container filled with suitcases and other baggage items has been confirmed experimentally. First experiments with heavily shielded nuclear materials have been carried out.

  18. Device for Detection of Explosives, Nuclear and Other Hazardous Materials in Luggage and Cargo Containers

    Science.gov (United States)

    Kuznetsov, Andrey; Evsenin, Alexey; Gorshkov, Igor; Osetrov, Oleg; Vakhtin, Dmitry

    2009-12-01

    Device for detection of explosives, radioactive and heavily shielded nuclear materials in luggage and cargo containers based on Nanosecond Neutron Analysis/Associated Particles Technique (NNA/APT) is under construction. Detection module consists of a small neutron generator with built-in position-sensitive detector of associated alpha-particles, and several scintillator-based gamma-ray detectors. Explosives and other hazardous chemicals are detected by analyzing secondary high-energy gamma-rays from reactions of fast neutrons with materials inside a container. The same gamma-ray detectors are used to detect unshielded radioactive and nuclear materials. An array of several neutron detectors is used to detect fast neutrons from induced fission of nuclear materials. Coincidence and timing analysis allows one to discriminate between fission neutrons and scattered probing neutrons. Mathematical modeling by MCNP5 and MCNP-PoliMi codes was used to estimate the sensitivity of the device and its optimal configuration. Comparison of the features of three gamma detector types—based on BGO, NaI and LaBr3 crystals is presented.

  19. 75 FR 64585 - Bulk Solid Hazardous Materials: Harmonization With the International Maritime Solid Bulk Cargoes...

    Science.gov (United States)

    2010-10-19

    ... nonsubstantive changes, however, to correct grammar, internal paragraph references, and a temperature conversion... means the English version of the ``International Maritime Solid Bulk Cargoes Code'' published by...

  20. Assembly and Transport of Microscopic Cargos via Reconfigurable Photoactivated Magnetic Microdockers.

    Science.gov (United States)

    Martinez-Pedrero, Fernando; Massana-Cid, Helena; Tierno, Pietro

    2017-05-01

    The realization of micromotors able to dock and transport microscopic objects in a fluid medium has direct applications toward the delivery of drugs and chemicals in small channels and pores, and the realization of functional wireless microrobots in lab-on-a-chip technology. A simple and general method to tow microscopic particles in water by using remotely controllable light-activated hematite microdockers is demonstrated. These anisotropic ferromagnetic particles can be synthesized in bulk and present the remarkable ability to be activated by light while independently manipulated via external fields. The photoactivation process induces a phoretic flow capable to attract cargos toward the surface of the propellers, while a rotating magnetic field is used to transport the composite particles to any location of the experimental platform. The method allows the assembling of small colloidal clusters of various sizes, composed by a skeleton of mobile magnetic dockers, which cooperatively keep, transport, and release the microscopic cargos. The possibility to easily reconfigure in situ the location of the docker above the cargo is demonstrated, which enables optimize transport and cargo release operations. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  1. Dynamics modeling and control of large transport aircraft in heavy cargo extraction

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    In this paper,a novel version of six-degree-of-freedom nonlinear model for transport aircraft motion in cargo extraction is developed and validated by the theoretical mechanics and flight mechanics.In this model constraint force and moment reflecting the flight dynamic effects of inner moving cargo are formulated.A methodology for a control law design in this phase is presented,which linearizes the aircraft dynamics making use of piecewise linearization and utilizes robust control technique for interval sys...

  2. FAM21 directs SNX27-retromer cargoes to the plasma membrane by preventing transport to the Golgi apparatus.

    Science.gov (United States)

    Lee, Seongju; Chang, Jaerak; Blackstone, Craig

    2016-03-09

    The endosomal network maintains cellular homeostasis by sorting, recycling and degrading endocytosed cargoes. Retromer organizes the endosomal sorting pathway in conjunction with various sorting nexin (SNX) proteins. The SNX27-retromer complex has recently been identified as a major endosomal hub that regulates endosome-to-plasma membrane recycling by preventing lysosomal entry of cargoes. Here, we show that SNX27 directly interacts with FAM21, which also binds retromer, within the Wiskott-Aldrich syndrome protein and SCAR homologue (WASH) complex. This interaction is required for the precise localization of SNX27 at an endosomal subdomain as well as for recycling of SNX27-retromer cargoes. Furthermore, FAM21 prevents cargo transport to the Golgi apparatus by controlling levels of phosphatidylinositol 4-phosphate, which facilitates cargo dissociation at the Golgi. Together, our results demonstrate that the SNX27-retromer-WASH complex directs cargoes to the plasma membrane by blocking their transport to lysosomes and the Golgi.

  3. Quantitative measurements and modeling of cargo-motor interactions during fast transport in the living axon

    Science.gov (United States)

    Seamster, Pamela E.; Loewenberg, Michael; Pascal, Jennifer; Chauviere, Arnaud; Gonzales, Aaron; Cristini, Vittorio; Bearer, Elaine L.

    2012-10-01

    The kinesins have long been known to drive microtubule-based transport of sub-cellular components, yet the mechanisms of their attachment to cargo remain a mystery. Several different cargo-receptors have been proposed based on their in vitro binding affinities to kinesin-1. Only two of these—phosphatidyl inositol, a negatively charged lipid, and the carboxyl terminus of the amyloid precursor protein (APP-C), a trans-membrane protein—have been reported to mediate motility in living systems. A major question is how these many different cargo, receptors and motors interact to produce the complex choreography of vesicular transport within living cells. Here we describe an experimental assay that identifies cargo-motor receptors by their ability to recruit active motors and drive transport of exogenous cargo towards the synapse in living axons. Cargo is engineered by derivatizing the surface of polystyrene fluorescent nanospheres (100 nm diameter) with charged residues or with synthetic peptides derived from candidate motor receptor proteins, all designed to display a terminal COOH group. After injection into the squid giant axon, particle movements are imaged by laser-scanning confocal time-lapse microscopy. In this report we compare the motility of negatively charged beads with APP-C beads in the presence of glycine-conjugated non-motile beads using new strategies to measure bead movements. The ensuing quantitative analysis of time-lapse digital sequences reveals detailed information about bead movements: instantaneous and maximum velocities, run lengths, pause frequencies and pause durations. These measurements provide parameters for a mathematical model that predicts the spatiotemporal evolution of distribution of the two different types of bead cargo in the axon. The results reveal that negatively charged beads differ from APP-C beads in velocity and dispersion, and predict that at long time points APP-C will achieve greater progress towards the presynaptic

  4. Status of NASA's commercial cargo and crew transportation initiative

    Science.gov (United States)

    Lindenmoyer, Alan; Stone, Dennis

    2010-03-01

    To stimulate the commercial space transportation industry, the National Aeronautics and Space Administration (NASA) is facilitating the demonstration of Commercial Orbital Transportation Services (COTS) to Low Earth Orbit (LEO) by private-sector companies. In 2006, NASA entered into funded agreements with two such companies to share NASA's 500 million investment, Space Exploration Technologies (SpaceX) and Rocketplane Kistler (RpK), each of which proposed to obtain the additional private financing needed to complete its flight demonstrations. In 2007, NASA terminated the agreement with RpK because it failed to meet a series of technical and financial milestones which were necessary to receive the incremental NASA payments. In 2008, NASA conducted another competition for the remaining 170 million of NASA funding and entered into a funded agreement with Orbital Sciences Corporation (OSC). This paper provides an overview of the COTS approach of SpaceX and OSC and the status of their efforts to develop reliable and cost-effective commercial transportation to serve the LEO marketplace.

  5. 49 CFR 180.407 - Requirements for test and inspection of specification cargo tanks.

    Science.gov (United States)

    2010-10-01

    ... appurtenances and structural attachments on the cargo tank including, but not limited to, suspension system...; (vii) Areas near upper coupler (fifth wheel) assembly attachments; (viii) Areas near suspension system... PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION HAZARDOUS...

  6. THE ASSESSMENT MODELS OF AIR POLLUTION DURING TRANSPORTATION OF BULK CARGO

    Directory of Open Access Journals (Sweden)

    M. M. Biliaiev

    2016-10-01

    Full Text Available Purpose. The scientific work is concentrated on development of 3D, 2D numerical models for the prediction of atmospheric pollution during transport of bulk cargo in the railway car. Methodology. To solve this problem numerical models were developed, based on the use of the motion equations of inviscid incompressible fluid and mass transfer, to determine the field of wind velocity near the cars and dispersion of dust in the atmosphere. For the numerical integration of the pollutant transport equation implicit alternating-triangular difference scheme was used. When constructing a difference scheme splitting of the transport equation is carried out that allows us to construct an efficient algorithm for solving a differential problem. Unknown value of the pollutant concentration at every step of splitting is determined by the explicit scheme – the method of point-to-point computation, which provides a simple numerical implementation of splitting equations. For numerical integration of the 3D equation for the velocity potential method of Richardson is applied. For numerical integration of the 2D equation for the velocity potential the method of total approximation is applied. The developed numerical models are the basis of established software package. On the basis of the constructed numerical models a computational experiment to assess the level of air pollution when demolition of coal dust from the gondola car was carried out. Findings. 3D, 2D numerical models that belong to the class «diagnostic models» were developed. These models take into account the main physical factors affecting the process of dust pollution dispersion in the atmosphere during transportation of bulk cargo, but require small costs of the computer time in the practice at the low and medium power machines. These models are used for serial calculations of various situations of scenarios related to issues of environmental protection and pollution intensity diagnostics for

  7. Local synaptic signaling enhances the stochastic transport of motor-driven cargo in neurons

    KAUST Repository

    Newby, Jay

    2010-08-23

    The tug-of-war model of motor-driven cargo transport is formulated as an intermittent trapping process. An immobile trap, representing the cellular machinery that sequesters a motor-driven cargo for eventual use, is located somewhere within a microtubule track. A particle representing a motor-driven cargo that moves randomly with a forward bias is introduced at the beginning of the track. The particle switches randomly between a fast moving phase and a slow moving phase. When in the slow moving phase, the particle can be captured by the trap. To account for the possibility that the particle avoids the trap, an absorbing boundary is placed at the end of the track. Two local signaling mechanisms-intended to improve the chances of capturing the target-are considered by allowing the trap to affect the tug-of-war parameters within a small region around itself. The first is based on a localized adenosine triphosphate (ATP) concentration gradient surrounding a synapse, and the second is based on a concentration of tau-a microtubule-associated protein involved in Alzheimer\\'s disease-coating the microtubule near the synapse. It is shown that both mechanisms can lead to dramatic improvements in the capture probability, with a minimal increase in the mean capture time. The analysis also shows that tau can cause a cargo to undergo random oscillations, which could explain some experimental observations. © 2010 IOP Publishing Ltd.

  8. Feasibility Study of Cargo Airship Transportation Systems Powered by New Green Energy Technologies

    Science.gov (United States)

    Skuza, Jonathan R.; Park, Yeonjoon; Kim, Hyun Jung; Seaman, Shane T.; King, Glen C.; Choi, Sang H.; Song, Kyo D.; Yoon, Hargsoon; Lee, Kunik

    2014-01-01

    The development of transportation systems that use new and sustainable energy technologies is of utmost importance due to the possible future shortfalls that current transportation modes will encounter because of increased volume and costs. The introduction and further research and development of new transportation and energy systems by materials researchers at the National Aeronautics and Space Administration (NASA) Langley Research Center (LaRC) and the Department of Transportation are discussed in this Technical Memorandum. In this preliminary study, airship concepts were assessed for cargo transportation using various green energy technologies capable of 24-hour operation (i.e., night and day). Two prototype airships were successfully constructed and tested at LaRC to demonstrate their feasibility: one with commercially available solar cells for operation during the daytime and one with microwave rectennas (i.e., rectifying antennas) developed in-house for night-time operation. The test results indicate the feasibility of a cargo transportation airship powered by new green energy sources and wireless power technology. Future applications will exploit new green energy sources that use materials and devices recently developed or are in the process of being developed at LaRC. These include quantum well SiGe solar cells; low, mid-, and high temperature thermoelectric modules; and wireless microwave and optical rectenna devices. This study examines the need and development of new energy sources for transportation, including the current status of research, materials, and potential applications.

  9. Opposing microtubule motors control motility, morphology and cargo segregation during ER-to-Golgi transport

    Directory of Open Access Journals (Sweden)

    Anna K. Brown

    2014-04-01

    Full Text Available We recently demonstrated that dynein and kinesin motors drive multiple aspects of endosomal function in mammalian cells. These functions include driving motility, maintaining morphology (notably through providing longitudinal tension to support vesicle fission, and driving cargo sorting. Microtubule motors drive bidirectional motility during traffic between the endoplasmic reticulum (ER and Golgi. Here, we have examined the role of microtubule motors in transport carrier motility, morphology, and domain organization during ER-to-Golgi transport. We show that, consistent with our findings for endosomal dynamics, microtubule motor function during ER-to-Golgi transport of secretory cargo is required for motility, morphology, and cargo sorting within vesicular tubular carriers en route to the Golgi. Our data are consistent with previous findings that defined roles for dynein-1, kinesin-1 (KIF5B and kinesin-2 in this trafficking step. Our high resolution tracking data identify some intriguing aspects. Depletion of kinesin-1 reduces the number of motile structures seen, which is in line with other findings relating to the role of kinesin-1 in ER export. However, those transport carriers that were produced had a much greater run length suggesting that this motor can act as a brake on anterograde motility. Kinesin-2 depletion did not significantly reduce the number of motile transport carriers but did cause a similar increase in run length. These data suggest that kinesins act as negative regulators of ER-to-Golgi transport. Depletion of dynein not only reduced the number of motile carriers formed but also caused tubulation of carriers similar to that seen for sorting nexin-coated early endosomes. Our data indicated that the previously observed anterograde–retrograde polarity of transport carriers in transit to the Golgi from the ER is maintained by microtubule motor function.

  10. Growth drivers of Finnish-Estonian general cargo transports

    Directory of Open Access Journals (Sweden)

    Olli-Pekka Hilmola

    2014-08-01

    Full Text Available Nearly the entire European trade of Finland is being executed through short sea shipping connections to Estonia, Sweden and Germany. Earlier the most important connections were to Sweden and Germany, but during Estonia’s new independence era, volumes to this alternative direction have increased considerably, and are continuously growing (time alone is good proxy for growth. This cannot be said for transport flows to Sweden, and Germany also holds high uncertainty. Based on the findings of this research, it is argued that Estonian connection growth was caused by different factors. One important factor was European Union membership in the year 2004. It should be emphasized that this was step-wise and was realized a decade ago. The main influence is that of the development of bulky trade. As measured in weight, both export and import of Finland with Estonia was found to be significant. However, in monetary terms only Finnish imports from Estonia was statistically significant. Finnish exports in turn to Estonia in value terms have contributed a negative effect (or even being insignificant. As the regression model was expanded, taking into account all three Baltic States and Poland, reliable additional findings couldn’t be drawn. Completed regression analysis shows that the explanation power of GDP based models became much lower after the years 2005‒2006.

  11. Multi-Criteria Optimisation of Liquid Cargo Transport According to Linguistic Approach to the Route Selection Task

    Directory of Open Access Journals (Sweden)

    Guze Sambor

    2017-04-01

    Full Text Available The main aim of the paper is to present the possibility of use of the multi-criteria optimization method Analytical Hierarchy Process (AHP to liquid cargo transportation by sea. Finding the optimal solution is not simple. There are many factors influencing the shipping process. In the case of liquid cargo, the most important thing is the safety of the crew, ship, and environment. Therefore, the Mathematical Theory of Evidence is introduced and used to determine the optimal path in terms of time and safety of transport. Moreover, the details of liquid cargo transport process are described with particular attention to ship to ship operations. Besides, the basic concept of the AHP method, steps of the algorithm are introduced. Finally, the multicriteria optimization of the transport of the liquid cargo from the Persian Gulf to Port of Gdansk is done. It is based on the experts′ opinions.

  12. Cargo Transport by Two Coupled Myosin Va Motors on Actin Filaments and Bundles.

    Science.gov (United States)

    Ali, M Yusuf; Vilfan, Andrej; Trybus, Kathleen M; Warshaw, David M

    2016-11-15

    Myosin Va (myoVa) is a processive, actin-based molecular motor essential for intracellular cargo transport. When a cargo is transported by an ensemble of myoVa motors, each motor faces significant physical barriers and directional challenges created by the complex actin cytoskeleton, a network of actin filaments and actin bundles. The principles that govern the interaction of multiple motors attached to the same cargo are still poorly understood. To understand the mechanical interactions between multiple motors, we developed a simple in vitro model in which two individual myoVa motors labeled with different-colored Qdots are linked via a third Qdot that acts as a cargo. The velocity of this two-motor complex was reduced by 27% as compared to a single motor, whereas run length was increased by only 37%, much less than expected from multimotor transport models. Therefore, at low ATP, which allowed us to identify individual motor steps, we investigated the intermotor dynamics within the two-motor complex. The randomness of stepping leads to a buildup of tension in the linkage between motors-which in turn slows down the leading motor-and increases the frequency of backward steps and the detachment rate. We establish a direct relationship between the velocity reduction and the distribution of intermotor distances. The analysis of run lengths and dwell times for the two-motor complex, which has only one motor engaged with the actin track, reveals that half of the runs are terminated by almost simultaneous detachment of both motors. This finding challenges the assumptions of conventional multimotor models based on consecutive motor detachment. Similar, but even more drastic, results were observed with two-motor complexes on actin bundles, which showed a run length that was even shorter than that of a single motor.

  13. 75 FR 34573 - Bulk Solid Hazardous Materials: Harmonization With the International Maritime Solid Bulk Cargoes...

    Science.gov (United States)

    2010-06-17

    ... Bulk MSDS Material Safety Data Sheet NCB National Cargo Bureau NEPA National Environmental Policy Act... material safety data sheet (MSDS) address some portions of proposed Sec. 148.60. We agree with the comment... in the form of an MSDS. e. One comment observed that, as proposed in the 1994 NPRM, Sec. 148.60(d...

  14. 76 FR 13313 - Hazardous Materials: Cargo Tank Motor Vehicle Loading and Unloading Operations

    Science.gov (United States)

    2011-03-11

    ... cargo transfer hoses on an adjacent tank car resulted in the release of chlorine. Three plant employees... of the explosion propelled a 300-pound tank car dome housing about \\1/3\\ mile away from the tank car... repaired fill hose and began to unload the gas from his 8,000-gallon tanker truck. In less than a...

  15. Model of Optimal Cargo Transport Structure by Full Container Ship on Predefined Sailing Route

    Directory of Open Access Journals (Sweden)

    Serđo Kos

    2004-01-01

    Full Text Available This paper presents the mathematical model for solving theproblem of defining optimal cargo transport structure, occurringwhen, on a predefined sailing route, adequate number ofcontainers of various types, masses and sizes, possibly includingRO!RO cargo, is to be selected, i.e., a "container lot" is to beestablished in loading ports with the aim of gaining maximumship profit and, at the same time, of exploiting useful load andtransport capacity of container ship as much as possible. Theimplementation of the proposed model enables considerableincrease in the efficiency of container ship operations. Themodel was tested using a numerical example with real data.The applied post-optimal analysis examines the influence ofchange in some values of the mathematical model on the resultingoptimal program.

  16. Effect of catch bonding on transport of cellular cargo by dynein motors

    Science.gov (United States)

    Nair, Anil; Chandel, Sameep; Mitra, Mithun K.; Muhuri, Sudipto; Chaudhuri, Abhishek

    2016-09-01

    Recent experiments have demonstrated that dynein motors exhibit catch bonding behavior, in which the unbinding rate of a single dynein decreases with increasing force, for a certain range of force. Motivated by these experiments, we study the effect of catch bonding on unidirectional transport properties of cellular cargo carried by multiple dynein motors. We introduce a threshold force bond deformation (TFBD) model, consistent with the experiments, wherein catch bonding sets in beyond a critical applied load force. We find catch bonding can result in dramatic changes in the transport properties, which are in sharp contrast to kinesin-driven unidirectional transport, where catch bonding is absent. We predict that under certain conditions, the average velocity of the cellular cargo can actually increase as applied load is increased. We characterize the transport properties in terms of a velocity profile plot in the parameter space of the catch bond strength and the stall force of the motor. This plot yields predictions that may be experimentally accessed by suitable modifications of motor transport and binding properties.

  17. HMPT: Hazardous Waste Transportation Live 27928, Test 27929

    Energy Technology Data Exchange (ETDEWEB)

    Simpson, Lewis Edward [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-03-17

    HMPT: Hazardous Waste Transportation (Live 27928, suggested one time and associated Test 27929, required initially and every 36 months) addresses the Department of Transportation (DOT) function-specific training requirements of the hazardous materials packagings and transportation (HMPT) Los Alamos National Laboratory (LANL) lab-wide training. This course addresses the requirements of the DOT that are unique to hazardous waste shipments. Appendix B provides the Title 40 Code of Federal Regulations (CFR) reference material needed for this course.

  18. Microtubule-binding protein doublecortin-like kinase 1 (DCLK1) guides kinesin-3-mediated cargo transport to dendrites.

    Science.gov (United States)

    Lipka, Joanna; Kapitein, Lukas C; Jaworski, Jacek; Hoogenraad, Casper C

    2016-02-01

    In neurons, the polarized distribution of vesicles and other cellular materials is established through molecular motors that steer selective transport between axons and dendrites. It is currently unclear whether interactions between kinesin motors and microtubule-binding proteins can steer polarized transport. By screening all 45 kinesin family members, we systematically addressed which kinesin motors can translocate cargo in living cells and drive polarized transport in hippocampal neurons. While the majority of kinesin motors transport cargo selectively into axons, we identified five members of the kinesin-3 (KIF1) and kinesin-4 (KIF21) subfamily that can also target dendrites. We found that microtubule-binding protein doublecortin-like kinase 1 (DCLK1) labels a subset of dendritic microtubules and is required for KIF1-dependent dense-core vesicles (DCVs) trafficking into dendrites and dendrite development. Our study demonstrates that microtubule-binding proteins can provide local signals for specific kinesin motors to drive polarized cargo transport.

  19. 77 FR 14327 - Bulk Packaging To Allow for Transfer of Hazardous Liquid Cargoes

    Science.gov (United States)

    2012-03-09

    ... FR Federal Register HMR Hazardous Materials Regulations; 49 CFR Parts 171-180 IBC Intermediate Bulk... Materials by Vessel'' (55 FR 37406), the Coast Guard allowed the use of Intermodal (IM) 101 and IM 102... describe the types of IBCs the Coast Guard would allow for the carriage of certain hazardous materials...

  20. Defective nuclear import of Tpr in Progeria reflects the Ran sensitivity of large cargo transport.

    Science.gov (United States)

    Snow, Chelsi J; Dar, Ashraf; Dutta, Anindya; Kehlenbach, Ralph H; Paschal, Bryce M

    2013-05-13

    The RanGTPase acts as a master regulator of nucleocytoplasmic transport by controlling assembly and disassembly of nuclear transport complexes. RanGTP is required in the nucleus to release nuclear localization signal (NLS)-containing cargo from import receptors, and, under steady-state conditions, Ran is highly concentrated in the nucleus. We previously showed the nuclear/cytoplasmic Ran distribution is disrupted in Hutchinson-Gilford Progeria syndrome (HGPS) fibroblasts that express the Progerin form of lamin A, causing a major defect in nuclear import of the protein, translocated promoter region (Tpr). In this paper, we show that Tpr import was mediated by the most abundant import receptor, KPNA2, which binds the bipartite NLS in Tpr with nanomolar affinity. Analyses including NLS swapping revealed Progerin did not cause global inhibition of nuclear import. Rather, Progerin inhibited Tpr import because transport of large protein cargoes was sensitive to changes in the Ran nuclear/cytoplasmic distribution that occurred in HGPS. We propose that defective import of large protein complexes with important roles in nuclear function may contribute to disease-associated phenotypes in Progeria.

  1. Molecular motors transporting cargos in viscoelastic cytosol: how to beat subdiffusion with a power stroke?

    CERN Document Server

    Goychuk, Igor; Metzler, Ralf

    2013-01-01

    Anomalously slow passive diffusion, $\\langle \\delta x^2(t)\\rangle\\simeq t^{\\alpha}$, with $0<\\alpha<1$, of larger tracers such as messenger RNA and endogenous submicron granules in the cytoplasm of living biological cells has been demonstrated in a number of experiments and has been attributed to the viscoelastic physical nature of the cellular cytoplasm. This finding provokes the question to which extent active intracellular transport is affected by this viscoelastic environment: does the subdiffusion of free submicron cargo such as vesicles and organelles always imply anomalously slow transport by molecular motors such as kinesins, that is, directed transport characterized by a sublinear growth of the mean distance, $\\langle x(t)\\rangle\\simeq t^{\\alpha_{\\rm eff}}$, with $0<\\alpha_{\\rm eff}<1$? Here we study a generic model approach combining the commonly accepted two-state Brownian ratchet model of kinesin motors based on the continuous-state diffusion along microtubule driven by a flashing bind...

  2. 33 CFR 401.32 - Cargo booms-deck cargo.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Cargo booms-deck cargo. 401.32... OF TRANSPORTATION SEAWAY REGULATIONS AND RULES Regulations Seaway Navigation § 401.32 Cargo booms—deck cargo. (a) Every vessel shall have cargo booms secured in a manner that affords maximum...

  3. NanoShuttles: Harnessing Motor Proteins to Transport Cargo in Synthetic Environments

    Science.gov (United States)

    Vogel, V.; Hess, H.

    Motors have become a crucial commodity in our daily lives, from transportation to driving conveyor belts that enable the sequential assembly of cars and other industrial machines. For the sequential assembly of building blocks at the nanoscale that would not assemble spontaneously into larger functional systems, however, active transport systems are not yet available. In contrast, cells have evolved sophisticated molecular machinery that drives movement and active transport. Driven by the conversion of chemical into mechanical energy, namely through hydrolysis of the biological fuel ATP, molecular motors enable cells to operate far away from equilibrium by transporting organelles and molecules to designated locations within the cell, often against concentration gradients. Inspired by the biological concept of active transport, major efforts are underway to learn how to build nanoscale transport systems that are driven by molecular motors. Emerging engineering principles are discussed of how to build tracks and junctions to guide such nanoshuttles, how to load them with cargo and control their speed, how to use active transport to assemble mesoscopic structures that would otherwise not assemble spontaneously and what polymeric materials to choose to integrate motors into MEMS and other biohybrid devices. Finally, two applications that exploit the physical properties of microtubules are discussed, surface imaging by a swarm of microtubules and a self-assembled picoNewton force meter to probe receptor-ligand interactions.

  4. 75 FR 9147 - Hazardous Materials: Transportation of Lithium Batteries

    Science.gov (United States)

    2010-03-01

    ...-AE44 Hazardous Materials: Transportation of Lithium Batteries AGENCY: Pipeline and Hazardous Materials... associated with the air transport of lithium cells and batteries. PHMSA and FAA will hold a public meeting on... they will be attending the Lithium Battery Public Meeting and wait to be escorted to the...

  5. Sulina and Danube-Black Sea Channels: Competitors or Allies on Cargo Transport in South-Eastern Europe?

    Directory of Open Access Journals (Sweden)

    Ionica Soare

    2015-10-01

    Full Text Available The two river channels which connect the Black Sea to the inland Romanian area, have constituted since the beginning of their building two very important transport routes for the cargo and passenger traffic (Sulina that have connected Black Sea to the internal ports of Romania, thus representing ”transport highways” of the Romanian economy. The present study tries to present the chronological evolution of these two shipping routes, regarding their importance to the cargo traffic, as well as the financial policy imposed by the administration of these channels. We will present and analyze retrospectively the major elements regarding the administration of these channels, a comparative analysis of the role of these two channels in the river cargo transport, consequently trying to predict a future evolution of these two river communication routes.

  6. Cargo Commercial Orbital Transportation Services Environmental Control and Life Support Integration

    Science.gov (United States)

    Duchesne, Stephanie; Thacker, Karen; Williams, Dave

    2012-01-01

    The International Space Station s (ISS) largest crew and cargo resupply vehicle, the Space Shuttle, retired in 2011. To help augment ISS resupply and return capability, NASA announced a project to promote the development of Commercial Orbital Transportation Services (COTS) for the ISS in January of 2006. By December of 2008, NASA entered into space act agreements with SpaceX and Orbital Sciences Corporation for COTS development and ISS Commercial Resupply Services (CRS). The intent of CRS is to fly multiple resupply missions each year to ISS with SpaceX s Dragon vehicle providing resupply and return capabilities and Orbital Science Corporation s Cygnus vehicle providing resupply capability to ISS. The ISS program launched an integration effort to ensure that these new commercial vehicles met the requirements of the ISS vehicle and ISS program needs. The Environmental Control and Life Support System (ECLSS) requirements cover basic cargo vehicle needs including maintaining atmosphere, providing atmosphere circulation, and fire detection and suppression. The ISS-COTS integration effort brought unique challenges combining NASA s established processes and design knowledge with the commercial companies new initiatives and limited experience with human space flight. This paper will discuss the ISS ECLS COTS integration effort including challenges, successes, and lessons learned.

  7. Transportation training: Focusing on movement of hazardous substances and wastes

    Energy Technology Data Exchange (ETDEWEB)

    Jones, E.; Moreland, W.M.

    1988-01-01

    Over the past 25 years extensive federal legislation involving the handling and transport of hazardous materials/waste has been passed that has resulted in numerous overlapping regulations administered and enforced by different federal agencies. The handling and transport of hazardous materials/waste involves a significant number of workers who are subject to a varying degree of risk should an accident occur during handling or transport. Effective transportation training can help workers address these risks and mitigate them, and at the same time enable ORNL to comply with the federal regulations concerning the transport of hazardous materials/waste. This presentation will outline how the Environmental and Health Protection Division's Technical Resources and Training Program at the Oak Ridge National Laboratory, working with transportation and waste disposal personnel, are developing and implementing a comprehensive transportation safety training program to meet the needs of our workers while satisfying appropriate federal regulations. 8 refs., 5 figs., 3 tabs.

  8. Design of an autonomous teleoperated cargo transporting vehicle for lunar base operations

    Science.gov (United States)

    Holt, James; Lao, Tom; Monali, Nkoy

    1989-01-01

    At the turn of the century NASA plans to begin construction of a lunar base. The base will likely consist of developed areas (i.e., habitation, laboratory, landing and launching sites, power plant) separated from each other due to safety considerations. The Self-Repositioning Track Vehicle (SRTV) was designed to transport cargo between these base facilities. The SRTV operates by using two robotic arms to raise and position segments of track upon which the vehicle travels. The SRTV utilizes the semiautonomous mobility (SAM) method of teleoperation; actuator-controlled interlocking track sections; two robotic arms each with five degrees of freedom; and these materials: titanium for structural members and aluminum for shell members, with the possible use of light-weight, high-strength composites.

  9. 76 FR 5483 - Hazardous Materials: Incorporation of Certain Cargo Tank Special Permits Into Regulations

    Science.gov (United States)

    2011-02-01

    ... products and technologies into the production and transportation stream, thereby providing a mechanism for... continue to be used in anhydrous ammonia service under specified conditions. The decision to consider the... community is particularly strong at developing new technologies and pioneering ways of moving materials...

  10. Novel propulsion of active colloids by self-induced field gradients with potential for cargo transport

    Science.gov (United States)

    Boymelgreen, Alicia; Yossifon, Gilad; Miloh, Touvia

    2016-11-01

    Localized electric field gradients, induced by the dual symmetry-breaking of an asymmetric particle adjacent to a wall are shown to potentially drive particle motion, even in a uniform field. Since the driving gradient is induced by the particle itself, we have termed this propulsion mechanism "self-dielectrophoresis" (sDEP), to distinguish from traditional DEP where the driving non-uniform field is externally fixed and particle direction is restricted. It is also shown that sDEP driven particles are natural cargo carriers, since the localized gradients can also trap and release targets selectively and on demand. This phenomenon is specifically characterized for Gold-Polystyrene Janus spheres, including the establishment of a non-dimensional parameter marking the critical frequency at which sDEP dominates low-frequency ICEP- evidenced by a reversal in particle direction. Additionally we demonstrate that localized gradients can transform the translating Janus particles into an externally controlled, mobile floating electrode with the ability to collect, transport and release a target sample a target 1/50 of its size. It is also shown that calculated control of the frequency enables selective sorting and transport - if the driving frequency is aligned with the positive-DEP (pDEP) response of a specific "target" and negative-DEP (nDEP) of any other contaminants, only the former will be transported with the Janus sphere. ISF,BSF,RBNI.

  11. Unexpected hazard of illegal immigration: Outbreak of viral myocarditis exacerbated by confinement and deprivation in a shipboard cargo container.

    Science.gov (United States)

    Li, Melissa K; Beck, Melinda A; Shi, Qing; Harruff, Richard C

    2004-06-01

    We present a group of 18 illegal immigrant stowaways who arrived in a shipboard cargo container suffering from gastroenteritis, dehydration, and malnutrition and showing evidence of viral myocarditis in 3 of 4 fatalities. Our investigation included an evaluation of the 2-week ocean voyage, analysis of medical records and laboratory results of the survivors, autopsies on the decedents, and viral studies on their heart tissue. Of 3 stowaways who died shipboard, 2 showed lymphocytic myocarditis and 1 could not be evaluated histologically due to decomposition. A fourth stowaway died 4 months after arrival with dilated cardiomyopathy and lymphocytic myocarditis. Reverse-transcriptase polymerase chain reaction and nucleotide sequencing of viral isolates from the decedents' heart tissues demonstrated Coxsackie virus B3 genome. We believe that these cases represent an outbreak of viral myocarditis, exacerbated by acute dehydration and malnutrition, due to confinement within the shipping container. Our evidence indicates that close confinement promoted the spread of the virus, and nutritional deprivation increased the stowaways' vulnerability. Furthermore, our observations support the conclusion, based on experimental studies, that nutritionally induced oxidative stress increased the virulence of the etiologic viral agent. In summary, these cases represent a potential infectious disease hazard of illegal immigration.

  12. Assessment of the risk of transporting plutonium dioxide by cargo aircraft

    Energy Technology Data Exchange (ETDEWEB)

    McSweeney, T.I.; Johnson, J.F.

    1977-06-01

    To enable easy comparison, all the plutonium shipping evaluations have used the same bases. In each, the results have been related to a future time--the early 1980s--when plutonium shipments are expected to be more frequent. The characteristics of the nuclear economy used in this analysis are: A total of 18 metric tons (MT) of plutonium is shipped annually, via the mode being evaluated. 100 kg of plutonium are transported per shipment. For air shipment, a truck and air segment are considered. The average shipping distance per shipment is 1,422 miles with 14 percent of the distance being by truck. Shipping systems and regulations are the same as in 1974. PuO/sub 2/ is shipped in 6M containers. The use of other shipping conditions could result in different risks than reported here. For the purposes of this study, plutonium dioxide was assumed to be carried exclusively in the 15-gal version of the 6M container. Unless otherwise noted, all references to 6M containers in the report refer to this particular size. Based on the shipping assumptions, the likelihood that an aircraft carrying a shipment will be involved in an accident is estimated to be about once in 450 years. For the projected shipping rate in the early 1980s, the likelihood of a release of plutonium as a result of shipment by air is one in 900 years for dioxide powder in the 6M container. The comparison of the truck and air transport modes for the same material showed truck transport to have less risk. At the same time, the air transport of plutonium dioxide was demonstrated to have a lower risk than other commonly accepted societal risks. The major contributor to the overall risk spectra for air transport was a cargo airplane, carrying plutonium dioxide, crashing at high speed into hard rock.

  13. Health risks in international container and bulk cargo transport due to volatile toxic compounds

    DEFF Research Database (Denmark)

    Baur, Xaver; Budnik, Lygia T; Zhao, Zhiwei

    2015-01-01

    on the toxic substance, its chemical reactivity, concentration, the temperature, the contaminated matrix (goods and packing materials), and the packing density in the transport units. Regulations on declaration and handling dangerous goods are mostly not followed. It is obvious that this hazardous situation...... shown to contain volatile toxic substances above the exposure limit values. Possible exposure to these toxic chemicals may occur not only for the applicators but also the receiver by off gassing from products, packing materials or transport units like containers. A number of intoxications, some...... with lethal outcome, occur not only during the fumigation, but also during freight transport (on bulk carriers and other transport vessels), as well as in the logistic lines during loading and unloading. Risk occupations include dock-workers, seafarers, inspectors, as well as the usually uninformed workers...

  14. Septin 9 interacts with kinesin KIF17 and interferes with the mechanism of NMDA receptor cargo binding and transport.

    Science.gov (United States)

    Bai, Xiaobo; Karasmanis, Eva P; Spiliotis, Elias T

    2016-03-15

    Intracellular transport involves the regulation of microtubule motor interactions with cargo, but the underlying mechanisms are not well understood. Septins are membrane- and microtubule-binding proteins that assemble into filamentous, scaffold-like structures. Septins are implicated in microtubule-dependent transport, but their roles are unknown. Here we describe a novel interaction between KIF17, a kinesin 2 family motor, and septin 9 (SEPT9). We show that SEPT9 associates directly with the C-terminal tail of KIF17 and interacts preferentially with the extended cargo-binding conformation of KIF17. In developing rat hippocampal neurons, SEPT9 partially colocalizes and comigrates with KIF17. We show that SEPT9 interacts with the KIF17 tail domain that associates with mLin-10/Mint1, a cargo adaptor/scaffold protein, which underlies the mechanism of KIF17 binding to the NMDA receptor subunit 2B (NR2B). Significantly, SEPT9 interferes with binding of the PDZ1 domain of mLin-10/Mint1 to KIF17 and thereby down-regulates NR2B transport into the dendrites of hippocampal neurons. Measurements of KIF17 motility in live neurons show that SEPT9 does not affect the microtubule-dependent motility of KIF17. These results provide the first evidence of an interaction between septins and a nonmitotic kinesin and suggest that SEPT9 modulates the interactions of KIF17 with membrane cargo.

  15. Pick-up, transport and release of a molecular cargo using a small-molecule robotic arm

    Science.gov (United States)

    Kassem, Salma; Lee, Alan T. L.; Leigh, David A.; Markevicius, Augustinas; Solà, Jordi

    2016-02-01

    Modern-day factory assembly lines often feature robots that pick up, reposition and connect components in a programmed manner. The idea of manipulating molecular fragments in a similar way has to date only been explored using biological building blocks (specifically DNA). Here, we report on a wholly artificial small-molecule robotic arm capable of selectively transporting a molecular cargo in either direction between two spatially distinct, chemically similar, sites on a molecular platform. The arm picks up/releases a 3-mercaptopropanehydrazide cargo by formation/breakage of a disulfide bond, while dynamic hydrazone chemistry controls the cargo binding to the platform. Transport is controlled by selectively inducing conformational and configurational changes within an embedded hydrazone rotary switch that steers the robotic arm. In a three-stage operation, 79-85% of 3-mercaptopropanehydrazide molecules are transported in either (chosen) direction between the two platform sites, without the cargo at any time fully dissociating from the machine nor exchanging with other molecules in the bulk.

  16. Anomalous transport of subdiffusing cargos by single kinesin motors: the role of mechanochemical coupling and anharmonicity of tether

    CERN Document Server

    Goychuk, Igor

    2014-01-01

    Here we generalize our previous model of molecular motors trafficking subdiffusing cargos in viscoelastic cytosol by (i) including mechanochemical coupling between cyclic conformational fluctuations of the motor protein driven by the reaction of ATP hydrolysis and its translational motion within the simplest two-state model of hand-over-hand motion of kinesin, and also (ii) by taking into account the anharmonicity of the tether between the motor and cargo (its maximally possible extension length). It is shown that the major earlier results such as occurrence of normal versus anomalous transport depending on the amplitude of binding potential, cargo size and the motor turnover frequency not only survive in this more realistic model, but the results also look very similar for the correspondingly adjusted parameters. However, this more realistic model displays a substantially larger thermodynamic efficiency due to a bidirectional mechanochemical coupling. For realistic parameters, the maximal thermodynamic effic...

  17. Cargo work for maritime operations

    Energy Technology Data Exchange (ETDEWEB)

    House, D.

    2005-07-01

    Previously published as Kemp & Young's Cargo Work, this new edition has been revised and expanded to reflect unit load containerised systems that are now used in the majority of cargo shipping, while retaining the necessary detail on transporting key classes of cargoes safely, efficiently and profitably. The book covers general principles and the latest international regulations that affect all cargo work, including cargo types and key characteristics of a wide range of cargo classes. It also details Roll On-Roll Off cargo handling, containerisation, equipment and offshore supply. Chapter 4 on bulk cargoes contains a section headed: Coal, characteristics, categories and procedures, precautions.

  18. A hopping mechanism for cargo transport by molecular motors in crowded microtubules

    CERN Document Server

    Goldman, Carla

    2010-01-01

    Most models designed to study the bidirectional movement of cargos as they are driven by molecular motors rely on the idea that motors of different polarities can be coordinated by external agents if arranged into a motor-cargo complex to perform the necessary work [gross04]. Although these models have provided us with important insights into these phenomena, there are still many unanswered questions regarding the mechanisms through which the movement of the complex takes place on crowded microtubules. For example (i) how does cargo-binding affect motor motility? and in connection with that - (ii) how does the presence of other motors (and also other cargos) on the microtubule affect the motility of the motor-cargo complex? We discuss these questions from a different perspective. The movement of a cargo is conceived here as a hopping process resulting from the transference of cargo between neighboring motors. In the light of this, we examine the conditions under which cargo might display bidirectional movemen...

  19. A review of modeling issues and analysis methods for the thermal response of cargoes transported in the Safe Secure Trailer subjected to fire environments

    Energy Technology Data Exchange (ETDEWEB)

    Howell, J.R. [Univ. of Texas, Austin, TX (United States). Dept. of Mechanical Engineering; Larsen, M.E. [Sandia National Labs., Albuquerque, NM (United States). High Consequence Assessment and Technology Dept.

    1998-05-01

    This paper discusses thermal analysis in support of probabilistic risk assessment (PRA) to predict the heating of cargoes shipped in vehicles like the Safe Secure Trailer. Fire environments contribute very significantly to the risk associated with ground transport of special nuclear materials. The tradeoff between thermal model complexity and the affordable number of scenarios used to represent the hazard space is discussed as it impacts PRA. The relevant heat transfer mechanisms are discussed along with the applicability of methods from the literature for analysis of these mechanisms. Many of the subject`s real problems remain too complex for affordable and rigorous analysis. Available models are generally restricted to idealizations that are quickly obviated by real effects. Approximate treatment methods, striving to produce conservative, realistic estimates are also discussed.

  20. ATMOSPHERE PROTECTION IN CASE OF EMERGENCY DURING TRANSPORTATION OF DANGEROUS CARGO

    Directory of Open Access Journals (Sweden)

    O. V. Berlov

    2016-02-01

    Full Text Available Purpose. The paper highlights the development of numerical models for prediction of atmospheric pollution in case of burning of the solid rocket propellant in a railway car, situated near the building on railway territory. These models can be used in predicting the effectiveness of neutralization upon the atmosphere protection for this type of accidents. Methodology.To solve this problem the numerical models based on the use of Navier-Stokes equations, to determine the velocity field of the wind flow near cars and buildings, and contaminants-transfer equations in the atmosphere were developed. For the numerical integration of pollutant transport equation was used implicit «change – triangle» difference scheme. When constructing a difference scheme physical and geometric cleavage of the transfer equation is carried out in four steps. Unknown value of pollutant concentration at each step of cleavage is determined by the explicit scheme – the method of «point-to-point computation». For the numerical integration of the Navier-Stokes equations are used implicit difference schemes. When carrying out computing experiment also takes into account: the velocity profile of wind flow; interaction between the building and the wind flow and flame jet of solid rocket propellant; the presence of a railroad car; inside which there is a source of pollution; instability of pollutant emissions. On the basis of constructed numerical models was performed the computer experiment for assessing the level of air pollution at dangerous cargo rail transportation in case of emergency at railway territory.The application calculations for the timely combustion products neutralization of solid rocket propellant were carried out. Findings. The numerical models that let promptly calculate air contamination in case of emergency during solid rocket propellant transportation, as well as calculate the rational parameters of pollutant neutralization process were developed by

  1. 49 CFR 195.4 - Compatibility necessary for transportation of hazardous liquids or carbon dioxide.

    Science.gov (United States)

    2010-10-01

    ... hazardous liquids or carbon dioxide. 195.4 Section 195.4 Transportation Other Regulations Relating to... necessary for transportation of hazardous liquids or carbon dioxide. No person may transport any hazardous liquid or carbon dioxide unless the hazardous liquid or carbon dioxide is chemically compatible with both...

  2. Transport of hazardous materials in the Amazon area; Transporte de produtos perigosos na regiao Amazonica

    Energy Technology Data Exchange (ETDEWEB)

    Cunha, Wallace de Castro [FURNAS Centrais Eletricas S.A., Rio de Janeiro, RJ (Brazil); Fernandes, Elton; Nassi, Carlos David [Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil). Coordenacao dos Programas de Pos-Graduacao de Engenharia (COPPE)

    2008-07-01

    Amongst several exploratory sources of the subject 'hazardous materials transport', it is distinguished: 'the threat to the environment'. This paper presents an exploratory investigation of this subject line in the Amazon region. In view of the diversity of 'existing hazardous materials' and the raised dimension of the oil transport and its derivatives in this context, this paper focused in these products. Regarding to the geographic region, the approach was given to the State of Amazon, considering the amplitude of this State in the Amazon region and the availability of data. Therefore, this work explores and analyzes macro aspects inherent to the State of Amazon pertinent to the oil transport and its derivatives. In the macro context, it is observed the necessity of a higher control in the transport of hazardous materials in the region. The absence of registered data and the unfamiliarity on the risks related to the transport of hazardous materials by authorities and transporters indicate a relative absence of qualification in the region to deal with the monitoring of the transport of hazardous materials. So far, it is not possible up till now to make any evaluation of the environment threats of accidents with transport of hazardous materials in the Amazon region.(author)

  3. 78 FR 42998 - Hazardous Materials: Improving the Safety of Railroad Transportation of Hazardous Materials

    Science.gov (United States)

    2013-07-18

    ... published on April 11, 2000 (65 FR 19477). Robert C. Lauby, Deputy Associate Administrator for Regulatory..., Washington, DC 20590, (202) 493-6050, Kurt.Eichenlaub@dot.gov ; or Mr. Karl Alexy, Staff Director, Hazardous... Karl.Alexy@dot.gov . SUPPLEMENTARY INFORMATION: The Secretary of Transportation (Secretary)...

  4. Models for microtubule cargo transport coupling the Langevin equation to stochastic stepping motor dynamics: Caring about fluctuations.

    Science.gov (United States)

    Bouzat, Sebastián

    2016-01-01

    One-dimensional models coupling a Langevin equation for the cargo position to stochastic stepping dynamics for the motors constitute a relevant framework for analyzing multiple-motor microtubule transport. In this work we explore the consistence of these models focusing on the effects of the thermal noise. We study how to define consistent stepping and detachment rates for the motors as functions of the local forces acting on them in such a way that the cargo velocity and run-time match previously specified functions of the external load, which are set on the base of experimental results. We show that due to the influence of the thermal fluctuations this is not a trivial problem, even for the single-motor case. As a solution, we propose a motor stepping dynamics which considers memory on the motor force. This model leads to better results for single-motor transport than the approaches previously considered in the literature. Moreover, it gives a much better prediction for the stall force of the two-motor case, highly compatible with the experimental findings. We also analyze the fast fluctuations of the cargo position and the influence of the viscosity, comparing the proposed model to the standard one, and we show how the differences on the single-motor dynamics propagate to the multiple motor situations. Finally, we find that the one-dimensional character of the models impede an appropriate description of the fast fluctuations of the cargo position at small loads. We show how this problem can be solved by considering two-dimensional models.

  5. 46 CFR 151.03-9 - Cargo.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Cargo. 151.03-9 Section 151.03-9 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES BARGES CARRYING BULK LIQUID HAZARDOUS MATERIAL CARGOES Definitions § 151.03-9 Cargo. This term means any liquid, gas or solid having...

  6. Basic Notion and Characteristics of Railway Transportation of Overweight Cargoes%铁路超重货物运输基本概念及特征分析

    Institute of Scientific and Technical Information of China (English)

    李笑红

    2012-01-01

    针对铁路超重货物的认识误区,对超重货物运输中相关概念的内涵及特征、超重产生的原因等进行了分析与探讨,同时也将超重货物与几个易混淆概念进行了比较.%In this paper, we analyzed the notion and characteristics of the overweight cargo transportation and the causes of the overweight cargoes and then compared the several confusing concepts related to overweight cargoes.

  7. Hazardous materials transportation: a risk-analysis-based routing methodology.

    Science.gov (United States)

    Leonelli, P; Bonvicini, S; Spadoni, G

    2000-01-07

    This paper introduces a new methodology based on risk analysis for the selection of the best route for the transport of a hazardous substance. In order to perform this optimisation, the network is considered as a graph composed by nodes and arcs; each arc is assigned a cost per unit vehicle travelling on it and a vehicle capacity. After short discussion about risk measures suitable for linear risk sources, the arc capacities are introduced by comparison between the societal and individual risk measures of each arc with hazardous materials transportation risk criteria; then arc costs are defined in order to take into account both transportation out-of-pocket expenses and risk-related costs. The optimisation problem can thus be formulated as a 'minimum cost flow problem', which consists of determining for a specific hazardous substance the cheapest flow distribution, honouring the arc capacities, from the origin nodes to the destination nodes. The main features of the optimisation procedure, implemented on the computer code OPTIPATH, are presented. Test results about shipments of ammonia are discussed and finally further research developments are proposed.

  8. 49 CFR 176.76 - Transport vehicles, freight containers, and portable tanks containing hazardous materials.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Transport vehicles, freight containers, and... TRANSPORTATION HAZARDOUS MATERIALS REGULATIONS CARRIAGE BY VESSEL General Handling and Stowage § 176.76 Transport... paragraphs (b) through (f) of this section, hazardous materials authorized to be transported by vessel may...

  9. THE INTERNATIONAL MULTIMODAL TRANSPORT OF HAZARDOUS GOODS AND WASTE

    Directory of Open Access Journals (Sweden)

    Giancarlo Carosso

    2012-01-01

    Full Text Available The international multimodal transport of hazardous goods and waste is a sector of remarkable economic importance. This transport activity is connected to several productive sectors and it can have considerable repercussions on the environment and health as well as on the safety of the workers and third parties that study in the same field. A certain part of the transport of hazardous goods and waste is managed by organized criminals who can obtain enormous savings by neglecting the measures necessary to protect the environment and safety. The legitimate economy is thus damaged and, above all, the efforts the International Community has made since the fifties-sixties, concerning the regulation of the complex aspects of this activity, are undermined. Two distinct judicial models exist at an international level concerning hazardous waste and goods: “transboundary movement” and “international transport”. The purpose of these models is to regulate a phenomenon which, although very complex and articulated, requires a homogeneous view. The international multimodal transport judicial model is here examined in 3 subsequent stages: (1 the general aspects and the details along the entire chain, starting from the loading operations, then going on to the transport itself and ending up with the unloading at its final destination; (2 the controls on the respect of international legislation on this topic; (3 a study case is conducted pertaining to the extensive PCB category which, from a judicial point of view, in certain cases can be considered hazardous goods and in other cases hazardous waste. The aim of the study is to supply decision makers with indications that can be used to improve the efficacy and the effectiveness of the regulations at a UN level and of the cascading particular agreements for the various means of transport. The international multimodal transport judicial model suffers from the uncertainties that were already

  10. Scatter in cargo radiography.

    Science.gov (United States)

    Miller, Erin A; Caggiano, Joseph A; Runkle, Robert C; White, Timothy A; Bevill, Aaron M

    2011-03-01

    As a complement to passive detection systems, radiographic inspection of cargo is an increasingly important tool for homeland security because it has the potential to detect highly attenuating objects associated with special nuclear material or surrounding shielding, in addition to screening for items such as drugs or contraband. Radiographic detection of such threat objects relies on high image contrast between regions of different density and atomic number (Z). Threat detection is affected by scatter of the interrogating beam in the cargo, the radiographic system itself, and the surrounding environment, which degrades image contrast. Here, we estimate the extent to which scatter plays a role in radiographic imaging of cargo containers. Stochastic transport simulations were performed to determine the details of the radiography equipment and surrounding environment, which are important in reproducing measured data and to investigate scatter magnitudes for typical cargo. We find that scatter plays a stronger role in cargo radiography than in typical medical imaging scenarios, even for low-density cargo, with scatter-to-primary ratios ranging from 0.14 for very low density cargo, to between 0.20 and 0.40 for typical cargo, and higher yet for dense cargo.

  11. Packaging and transportation manual. Chapter on the packaging and transportation of hazardous and radioactive waste

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-03-01

    The purpose of this chapter is to outline the requirements that Los Alamos National Laboratory employees and contractors must follow when they package and ship hazardous and radioactive waste. This chapter is applied to on-site, intra-Laboratory, and off-site transportation of hazardous and radioactive waste. The chapter contains sections on definitions, responsibilities, written procedures, authorized packaging, quality assurance, documentation for waste shipments, loading and tiedown of waste shipments, on-site routing, packaging and transportation assessment and oversight program, nonconformance reporting, training of personnel, emergency response information, and incident and occurrence reporting. Appendices provide additional detail, references, and guidance on packaging for hazardous and radioactive waste, and guidance for the on-site transport of these wastes.

  12. 46 CFR 153.908 - Cargo viscosity and melting point information; measuring cargo temperature during discharge...

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Cargo viscosity and melting point information; measuring..., LIQUEFIED GAS, OR COMPRESSED GAS HAZARDOUS MATERIALS Operations Documents and Cargo Information § 153.908 Cargo viscosity and melting point information; measuring cargo temperature during discharge:...

  13. Targeting immunoliposomes to transferrin receptors on brain capillary endothelial cells as a mean for cargo transport across the blood-brain barrier

    DEFF Research Database (Denmark)

    Johnsen, Kasper Bendix; Larsen, Annette Burkhart; Bruun, Jonas;

    2016-01-01

    transport further into the CNS. We studied transferrin receptor-targeted (OX26) immunoliposomes containing oxaliplatin with the aim of quantifying the uptake of OX26, liposomes and oxaliplatin in BCECs and the remaining CNS. The uptake of the immunoliposomes and their cargo was studied in 18-dayold rats...... higher both in vitro and in vivo when compared to isotypic IgG-conjugated liposomes. Quantitative analyses after capillary depletion revealed cargo transport from BCECs to the remaining CNS, but not differences could be detected between OX26- conjugated and isotype IgG control liposomes in vivo, whereas...

  14. Interaction of the Human Papillomavirus E6 Oncoprotein with Sorting Nexin 27 Modulates Endocytic Cargo Transport Pathways.

    Directory of Open Access Journals (Sweden)

    Ketaki Ganti

    2016-09-01

    Full Text Available A subset of high-risk Human Papillomaviruses (HPVs are the causative agents of a large number of human cancers, of which cervical is the most common. Two viral oncoproteins, E6 and E7, contribute directly towards the development and maintenance of malignancy. A characteristic feature of the E6 oncoproteins from cancer-causing HPV types is the presence of a PDZ binding motif (PBM at its C-terminus, which confers interaction with cellular proteins harbouring PDZ domains. Here we show that this motif allows E6 interaction with Sorting Nexin 27 (SNX27, an essential component of endosomal recycling pathways. This interaction is highly conserved across E6 proteins from multiple high-risk HPV types and is mediated by a classical PBM-PDZ interaction but unlike many E6 targets, SNX27 is not targeted for degradation by E6. Rather, in HPV-18 positive cell lines the association of SNX27 with components of the retromer complex and the endocytic transport machinery is altered in an E6 PBM-dependent manner. Analysis of a SNX27 cargo, the glucose transporter GLUT1, reveals an E6-dependent maintenance of GLUT1 expression and alteration in its association with components of the endocytic transport machinery. Furthermore, knockdown of E6 in HPV-18 positive cervical cancer cells phenocopies the loss of SNX27, both in terms of GLUT1 expression levels and its vesicular localization, with a concomitant marked reduction in glucose uptake, whilst loss of SNX27 results in slower cell proliferation in low nutrient conditions. These results demonstrate that E6 interaction with SNX27 can alter the recycling of cargo molecules, one consequence of which is modulation of nutrient availability in HPV transformed tumour cells.

  15. Cargo transport by sea and road - Technical and economical environmental factors

    DEFF Research Database (Denmark)

    Kristensen, Hans Otto Holmegaard

    2006-01-01

    This paper presents the background for a method of calculating the energy demand for different ship types using only a relatively few, but important parameters. It is an empirical method, based on a statistical analysis of the main parameters of different ship types in order to establish represen......This paper presents the background for a method of calculating the energy demand for different ship types using only a relatively few, but important parameters. It is an empirical method, based on a statistical analysis of the main parameters of different ship types in order to establish......)). >> By combining the statistical analysis with a subsequent power prediction, it has been possible to develop a method which can calculate the energy consumption as a function of only 3 general parameters, namely the size of the ship (more precisely the capacity), the ship's speed and the average cargo utilization...

  16. 29 CFR 1917.153 - Spray painting (See also § 1917.2, definition of Hazardous cargo, materials, substance, or...

    Science.gov (United States)

    2010-07-01

    ... under construction, major repair or rebuilding of terminal structures, or portable spraying apparatus..., splices or connections. (iv) Portable electric lights shall not be used during spraying operations. Lights... thereafter to exhaust hazardous vapor concentrations. (7) Rotating fan elements shall be nonsparking or...

  17. Air Cargo Security

    Science.gov (United States)

    2007-07-30

    passenger and all-cargo aircraft. The air cargo system consists of a large, complex distribution network linking manufacturers and shippers to freight...free transportation to San Jose, California. His only luggage was a guitar case that concealed hammers, mallets, a knife, and a spear gun. At the...authorities and airplane manufacturers study methods to mitigate the effects of in-flight explosions.76 The FAA has had a active research program in blast

  18. The ArfGAP2/3 Glo3 and ergosterol collaborate in transport of a subset of cargoes

    Directory of Open Access Journals (Sweden)

    Alejandro F. Estrada

    2015-07-01

    Full Text Available Proteins reach the plasma membrane through the secretory pathway in which the trans Golgi network (TGN acts as a sorting station. Transport from the TGN to the plasma membrane is maintained by a number of different pathways that act either directly or via the endosomal system. Here we show that a subset of cargoes depends on the ArfGAP2/3 Glo3 and ergosterol to maintain their proper localization at the plasma membrane. While interfering with neither ArfGAP2/3 activity nor ergosterol biosynthesis individually significantly altered plasma membrane localization of the tryptophan transporter Tat2, the general amino acid permease Gap1 and the v-SNARE Snc1, in a Δglo3 Δerg3 strain those proteins accumulated in internal endosomal structures. Export from the TGN to the plasma membrane and recycling from early endosomes appeared unaffected as the chitin synthase Chs3 that travels along these routes was localized normally. Our data indicate that a subset of proteins can reach the plasma membrane efficiently but after endocytosis becomes trapped in endosomal structures. Our study supports a role for ArfGAP2/3 in recycling from endosomes and in transport to the vacuole/lysosome.

  19. The concept of the development of cargo container transport system within airport

    Directory of Open Access Journals (Sweden)

    Bernd Hentschel

    2012-09-01

    Full Text Available Background: The transport of luggage units between the check-in terminal and airplanes is realized by the use of very simple transport solutions and manual reloading of the luggage. The luggage trolleys are used for the transport purposes, which are hitched to the mover and moved directly to the surroundings of the airplane. The loading and unloading of luggage is performed manually. Regarding actual safety requirements there was a need to create a new transport system, working in a closed cycle and based on the device for automatic loading and unloading of luggage units. Methods: Various potential variants of the device were generated based on results of analytical researches by the use of the morphological schema. The detail evaluation and the optimization of individual variants allow to prepare the concept of the complex method to solve problems of the reliable transport of luggage units within an airport. Results: The closed transport system was created as a result of the innovative project. The main element of this system is a container trolley, which is equipped in five storage layers. By the use of the special mover and gravitational forces, luggage units can be transported and placed inside this trolley as well as being loaded and unloaded. This solution enables to move 200 pieces of luggage in one transport cycle from the check-in terminal to the hatchway of the airplane.

  20. Optimization of city transportation of cargoes with use of system researches in the field of logistics

    Directory of Open Access Journals (Sweden)

    Олександр Павлович Кіркін

    2015-03-01

    Full Text Available In market working conditions, the enterprises need to maintain the competitiveness constantly. It is reached due to increase of standards of customer service and application of the latest technologies of management and production, including logistics. Over time there were following kinds of logistics: transport, warehouse, supply, production, etc. Thus, there is some parallel methodological development in the field of logistics and creation of logistic chains and systems at various stages of life cycle of goods. Thus, for city transportations, except high requirements to ecology and the impacts on the person inherent quick search of administrative decisions on effective customer service for the minimum time is. The warehouse logistics is an intermediate link between economic models by definition of stocks and parties of purchase, and transport operations which these indicators influence. Thus, system researches in the field of warehouse and transport logistic allow to coordinate transport and warehouse operations in uniform indicators, and also to expand methods of transport logistics. Planning and management of transport operations with the solution of problems of the target conflict can be used only for continuous transport sizes. First of all it is connected with impossibility of accumulation of transport works. It is necessary to notice feature of the solution of problems of the target conflict which can carry as the end result, and it can be presented by function, including function of distribution of a random variable. Therefore, the solution of a task can be used in imitating modeling. For transport operations it is necessary to consider two cases: the maximum intensity of service can't be increased and possibility of accumulation of intensity of service at the expense of additional resources

  1. MELTER: A model of the thermal response of cargos transported in the Safe-Secure Trailer subject to fire environments for risk assessment applications

    Energy Technology Data Exchange (ETDEWEB)

    Larsen, M.E.

    1994-08-01

    MELTER is an analysis of cargo responses inside a fire-threatened Safe-Secure Trailer (SST) developed for the Defense Program Transportation Risk Assessment (DPTRA). Many simplifying assumptions are required to make the subject problem tractable. MELTER incorporates modeling which balances the competing requirements of execution speed, generality, completeness of essential physics, and robustness. Input parameters affecting the analysis include those defining the fire scenario, those defining the cargo loaded in the SST, and those defining properties of the SST. For a specified fire, SST, and cargo geometry MELTER predicts the critical fire duration that will lead to a failure. The principal features of the analysis include: (a) Geometric considerations to interpret fire-scenario descriptors in terms of a thermal radiation boundary condition, (b) a simple model of the SST`s wall combining the diffusion model for radiation through optically-thick media with an endothermic reaction front to describe the charring of dimensional, rigid foam in the SST wall, (c) a transient radiation enclosure model, (d) a one-dimensional, spherical idealization of the shipped cargos providing modularity so that cargos of interest can be inserted into the model, and (e) associated numerical methods to integrate coupled, differential equations and find roots.

  2. Defense Transportation: DOD Needs to Take Actions to Improve the Transportation of Hazardous Material Shipments

    Science.gov (United States)

    2014-05-01

    Air Force, the Navy, and the Marine Corps; and DOT’s Pipeline and Hazardous Materials Safety Administration. See appendix I for more information on...is a viable microorganism or its toxin that causes, or may cause, human disease. 31DOD guidance for safeguarding biological select agents and...Defense for Transportation Policy; the Defense Logistics Agency; the Army, the Air Force, the Navy, the Marine Corps; and DOT’s Pipeline and

  3. 76 FR 82163 - Hazardous Materials: Harmonization With the United Nations Recommendations on the Transport of...

    Science.gov (United States)

    2011-12-30

    ... Hazardous Materials: Harmonization With the United Nations Recommendations on the Transport of Dangerous... United Nations Recommendations on the Transport of Dangerous Goods: Model Regulations (UN Model... and from the United States. In this document, PHMSA responds to administrative appeals,...

  4. Modelagem para localização de hubs no transporte de encomendas expressas Modelling for location hubs in the express cargo transport

    Directory of Open Access Journals (Sweden)

    Javier Antonio Timaná Alamo

    2006-12-01

    Full Text Available Na presente pesquisa se propõe um modelo matemático de programação linear com variáveis binárias 0/1, para projetar a configuração de uma rede de distribuição de encomendas expressas, visando minimizar os custos e garantindo um bom nível de serviço. O modelo, que é uma modificação da formulação proposta por O’Kelly, define as posições dos hubs, a alocação deles às demais instalações físicas e a construção de roteiros com apenas uma parada intermediária, o que confere mais agilidade ao atendimento da demanda de transporte de carga. Considera-se a instalação de um único hub maior (Hub Principal, que serve como ponto de transbordo para os fluxos de carga entre as distintas regiões de um território, e um conjunto de terminais regionais (mini-hubs, servindo como ponto de conexão, unicamente, para os fluxos de carga existentes em um determinado raio de cobertura. Foram propostas extensões que incluem uma restrição da capacidade operacional do Hub Principal, para evitar seu congestionamento, e duas diferentes estratégias de induzir o aumento de fluxo de carga manipulado pelos mini-hubs. O modelo proposto e suas extensões foram aplicados ao estudo de um caso real, obtendo-se resultados consistentes e uma redução significativa no custo total da rede de distribuição da empresa analisada.This study proposes a mathematical model of linear programming with binary variables 0/1 to project the configuration of a distribution network for express cargo which aims to minimize costs and guarantee a high level of service. The model, which is a modification of the formulation proposed by O’Kelly, defines the position of the hubs, their allocation regarding the other physical installations, and the building of itineraries with only one intermediate stop, which increases agility in meeting the demand of cargo transport. It assumes the installation of a single, major hub (Main Hub, which serves as the transfer point for

  5. 77 FR 31274 - Hazardous Materials: Harmonization With the United Nations Recommendations on the Transport of...

    Science.gov (United States)

    2012-05-25

    ... 2137-AE83 Hazardous Materials: Harmonization With the United Nations Recommendations on the Transport... Goods Regulations (TDG Regulations), and the United Nations Recommendations on the Transport of... hazardous materials internationally, to, from, and within the United States. In this notice of...

  6. Imaging and Quantitation Techniques for Tracking Cargo along Endosome-to-Golgi Transport Pathways

    Directory of Open Access Journals (Sweden)

    Paul A. Gleeson

    2013-02-01

    Full Text Available Recent improvements in the resolution of light microscopy, coupled with the development of a range of fluorescent-based probes, have provided new approaches to dissecting membrane domains and the regulation of membrane trafficking. Here, we review these advances, as well as highlight developments in quantitative image analysis and novel unbiased analytical approaches to quantitate protein localization. The application of these approaches to endosomal sorting and endosome-to-Golgi transport is discussed.

  7. 46 CFR 153.251 - Independent cargo tanks.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Independent cargo tanks. 153.251 Section 153.251... CARRYING BULK LIQUID, LIQUEFIED GAS, OR COMPRESSED GAS HAZARDOUS MATERIALS Design and Equipment Cargo Tanks § 153.251 Independent cargo tanks. All independent cargo tank must meet § 38.05-10 (a)(1), (b), (d),...

  8. 46 CFR 151.13-5 - Cargo segregation-tanks.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Cargo segregation-tanks. 151.13-5 Section 151.13-5... CARRYING BULK LIQUID HAZARDOUS MATERIAL CARGOES Cargo Segregation § 151.13-5 Cargo segregation—tanks. (a... symbols used in lines 1 and 2, in order, under the tank segregation column of Table 151.05....

  9. 46 CFR 151.45-4 - Cargo-handling.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Cargo-handling. 151.45-4 Section 151.45-4 Shipping COAST... LIQUID HAZARDOUS MATERIAL CARGOES Operations § 151.45-4 Cargo-handling. (a) On a United States tank barge... the persons in charge of cargo handling. (h) Auxiliary steam, air, fuel, or electric current. When...

  10. 46 CFR 151.45-6 - Maximum amount of cargo.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Maximum amount of cargo. 151.45-6 Section 151.45-6 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES BARGES CARRYING BULK LIQUID HAZARDOUS MATERIAL CARGOES Operations § 151.45-6 Maximum amount of cargo. (a)...

  11. Towards monitoring transport of single cargos across individual nuclear pore complexes by time-lapse atomic force microscopy.

    Science.gov (United States)

    Huang, Ning-Ping; Stubenrauch, Mike; Köser, Joachim; Taschner, Nicole; Aebi, Ueli; Stolz, Martin

    2010-08-01

    A new preparation procedure was developed for the stable adsorption of either the cytoplasmic or the nuclear face of native (i.e. in physiological buffer without detergent extraction and in the absence of chemical fixatives) Xenopus oocyte nuclear envelopes (NEs) onto silicon (Si) surfaces. This yields optimal structural preservation of the nuclear pore complexes (NPCs) without compromising their functional properties. The functional viability of thus prepared NPCs was documented by time-lapse atomic force microscopy (AFM) of the reversible calcium-mediated opening (i.e. +Ca(2+)) and closing (i.e. -Ca(2+)) of the iris diaphragm-like distal ring topping the NPCs' nuclear baskets. Moreover, site-specific single colloidal gold particle detection was documented by AFM imaging one and the same NPC before and after immuno-gold labeling the sample with a nucleoporin-specific antibody. With this new preparation protocol at hand, we should eventually be able to follow by time-lapse AFM transport of single gold-conjugated cargos across individual NPCs.

  12. Importance of anisotropy in detachment rates for force production and cargo transport by a team of motor proteins.

    Science.gov (United States)

    Takshak, Anjneya; Kunwar, Ambarish

    2016-05-01

    Many cellular processes are driven by collective forces generated by a team consisting of multiple molecular motor proteins. One aspect that has received less attention is the detachment rate of molecular motors under mechanical force/load. While detachment rate of kinesin motors measured under backward force increases rapidly for forces beyond stall-force; this scenario is just reversed for non-yeast dynein motors where detachment rate from microtubule decreases, exhibiting a catch-bond type behavior. It has been shown recently that yeast dynein responds anisotropically to applied load, i.e. detachment rates are different under forward and backward pulling. Here, we use computational modeling to show that these anisotropic detachment rates might help yeast dynein motors to improve their collective force generation in the absence of catch-bond behavior. We further show that the travel distance of cargos would be longer if detachment rates are anisotropic. Our results suggest that anisotropic detachment rates could be an alternative strategy for motors to improve the transport properties and force production by the team.

  13. Regional, national and international security requirements for the transport of nuclear cargo by sea

    Energy Technology Data Exchange (ETDEWEB)

    Booker, P.A.; Barnwell, I. [Marine Operations, BNFL International Transport and British Nuclear Group Security (United Kingdom)

    2004-07-01

    Since the beginning of the nuclear age in the 1940's, the world has focused on the immense possibilities of nuclear power with both its destructive and productive capabilities. The civil nuclear industry in the UK, as in most nuclear weapons states, grew from the military facilities built in the post war years under the political climate of the Cold War. In the early years of the industry, civil and defence nuclear facilities were inextricably linked both in public perceptions and the regulatory infrastructure under which they operated. The nuclear arms race and the spread of communism overshadowed people's perceptions of there being two separate uses of nuclear material. This was a double edged sword which initially allowed the industry to develop largely unhindered by public concerns but latterly meant the industry could not break away from its roots and to many is still perceived as a dangerous and destructive force. Regulatory frameworks governing all aspects of the industry have developed both nationally and internationally driven by valid public concerns, political agendas and an international consensus that the unregulated use of nuclear material has catastrophic possibilities on an international scale. With the internationalisation of the civil nuclear industry and the costs associated with developing facilities to fully support each stage of the fuel cycle, from enrichment, fuel manufacturing, reprocessing and waste remediation, it became inevitable that a transport infrastructure would develop to make best use of the facilities. Regulations, both national and international are implicit in ensuring the security of nuclear material in transit. Due to the physical size of many of the irradiated fuel packages and implications of the changes to transport safety regulations, international transports of nuclear material, other than within mainland Europe, is predominantly carried out by sea.

  14. Natural hazard impacts on transport systems: analyzing the data base of transport accidents in Russia

    Science.gov (United States)

    Petrova, Elena

    2015-04-01

    We consider a transport accident as any accident that occurs during transportation of people and goods. It comprises of accidents involving air, road, rail, water, and pipeline transport. With over 1.2 million people killed each year, road accidents are one of the world's leading causes of death; another 20-50 million people are injured each year on the world's roads while walking, cycling, or driving. Transport accidents of other types including air, rail, and water transport accidents are not as numerous as road crashes, but the relative risk of each accident is much higher because of the higher number of people killed and injured per accident. Pipeline ruptures cause large damages to the environment. That is why safety and security are of primary concern for any transport system. The transport system of the Russian Federation (RF) is one of the most extensive in the world. It includes 1,283,000 km of public roads, more than 600,000 km of airlines, more than 200,000 km of gas, oil, and product pipelines, 115,000 km of inland waterways, and 87,000 km of railways. The transport system, especially the transport infrastructure of the country is exposed to impacts of various natural hazards and weather extremes such as heavy rains, snowfalls, snowdrifts, floods, earthquakes, volcanic eruptions, landslides, snow avalanches, debris flows, rock falls, fog or icing roads, and other natural factors that additionally trigger many accidents. In June 2014, the Ministry of Transport of the RF has compiled a new version of the Transport Strategy of the RF up to 2030. Among of the key pillars of the Strategy are to increase the safety of the transport system and to reduce negative environmental impacts. Using the data base of technological accidents that was created by the author, the study investigates temporal variations and regional differences of the transport accidents' risk within the Russian federal regions and a contribution of natural factors to occurrences of different

  15. Microbial behaviour and cross contamination between cargoes in containerized transportation of food

    DEFF Research Database (Denmark)

    Abban, Stephen

    involved in foodborne disease outbreaks and their use in the present study have been discussed. Both Gram negative and Gram positive bacteria have been used in various experiments. The history of containerized transportation and its revolutionary role in the world of commerce is also briefly traced...... contamination scenarios involving both biotic and abiotic surfaces alongside the factors affecting the process have been briefly discussed. Cleaning and disinfection scenarios in related food hygiene environments have been looked into in the literature as well. The experimental work was in several phases...... the role of selected wavelengths and the type of surface material on the sensitivity of detecting various food residues on the surfaces. Wavelengths in the 365-445 nm regions consistently illuminated both plant and animal food residue to different extents; the optimal wavelength differed for various...

  16. Measurement of the Logistic Customer Service Level in Commercial Cargo Motor Transport Companies

    Directory of Open Access Journals (Sweden)

    Kadłubek Marta

    2014-11-01

    Full Text Available The term of logistic customer service is defined as the abilities or skills to meet the customer’s requirements and expectations, chiefly in terms of the time and place of deliveries, while using all available forms of logistic activity, including transport, storage, and the management of inventories, information and packages. As each of the logistic activities has an effect on the customer receiving right product or service, in its proper condition, in the correct time and space, and at reasonable costs, so seeking the proper service comes down to managing logistic activities in such a manner, as to achieve the essential level of customer satisfaction at the lowest possible costs.

  17. Microbial behaviour and cross contamination between cargoes in containerized transportation of food

    DEFF Research Database (Denmark)

    Abban, Stephen

    involved in foodborne disease outbreaks and their use in the present study have been discussed. Both Gram negative and Gram positive bacteria have been used in various experiments. The history of containerized transportation and its revolutionary role in the world of commerce is also briefly traced...... the role of selected wavelengths and the type of surface material on the sensitivity of detecting various food residues on the surfaces. Wavelengths in the 365-445 nm regions consistently illuminated both plant and animal food residue to different extents; the optimal wavelength differed for various...... a useful way of choosing the right disinfectant for containers having linings composed of diverse materials. Experiments were also conducted to understand the various (micro)-environmental factors that are critical in the survival and transfer of pathogens under transit conditions. This involved exposure...

  18. 49 CFR 1548.21 - Screening of cargo.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Screening of cargo. 1548.21 Section 1548.21... cargo. An IAC may only screen cargo for transport on a passenger aircraft under §§ 1544.205 and 1546.205 if the IAC is a certified cargo screening facility as provided in part 1549....

  19. Hazardous materials transportation. (Latest citations from the EI Compendex*plus database). Published Search

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-04-01

    The bibliography contains citations concerning the transportation of hazardous chemicals, gases, explosives, and spent nuclear fuel. Liquefied natural gas transportation is emphasized. Tanker ships, containers, and pipelines for these materials are discussed along with truck, rail, air, and submarine transportation. Safety programs and routing information are presented. Hazards specific to arctic shipping are included. (Contains 50-250 citations and includes a subject term index and title list.) (Copyright NERAC, Inc. 1995)

  20. Influence of direct motor-motor interaction in models for cargo transport by a single team of motors

    CERN Document Server

    Bouzat, Sebastian; 10.1088/1478-3975/7/4/046009

    2010-01-01

    We analyze theoretically the effects of excluded-volume interactions between motors on the dynamics of a cargo driven by multiple motors. The model considered shares many commons with other recently proposed in the literature, with the addition of direct interaction between motors and motor back steps. The cargo is assumed to follow a continuum Langevin dynamics, while individual motors evolve following a Monte Carlo algorithm based on experimentally accessible probabilities for discrete forward and backward jumps, and attachment and detachment rates. The links between cargo and motors are considered as non linear springs. By means of numerical simulations we compute the relevant quantities characterizing the dynamical properties of the system, and we compare the results to those for non interacting motors. We find that interactions lead to quite relevant changes in the force-velocity relation for cargo, with a considerable reduction of the stall force, and cause also a notable decrease of the run length. The...

  1. Complexity in human transportation networks: A comparative analysis of worldwide air transportation and global cargo ship movements

    CERN Document Server

    O'Danleyman, Grastivia; Seebens, Hanno; Blasius, Bernd; Brockmann, Dirk

    2011-01-01

    We present a comparative network theoretic analysis of the two largest global transportation networks: The worldwide air-transportation network (WAN) and the global cargoship network (GCSN). We show that both networks exhibit striking statistical similarities despite significant differences in topology and connectivity. Both networks exhibit a discontinuity in node and link betweenness distributions which implies that these networks naturally segragate in two different classes of nodes and links. We introduce a technique based on effective distances, shortest paths and shortest-path trees for strongly weighted symmetric networks and show that in a shortest-path-tree representation the most significant features of both networks can be readily seen. We show that effective shortest-path distance, unlike conventional geographic distance measures, strongly correlates with node centrality measures. Using the new technique we show that network resilience can be investigated more precisely than with contemporary tech...

  2. Criticality analysis for hazardous materials transportation; Classificacao da criticidade das rotas do transporte rodoviario de produtos perigosos da BRASKEM

    Energy Technology Data Exchange (ETDEWEB)

    Oliveira, Katia; Brady, Mariana [Det Norske Veritas (DNV), Rio de Janeiro, RJ (Brazil); Diniz, Americo [BRASKEM S.A., Sao Paulo, SP (Brazil)

    2008-07-01

    The bad conditions of Brazilians roads drive the companies to be more exigent with the transportation of hazardous materials to avoid accidents or materials releases with actions to contain the releases to community and water sources. To minimize this situation, DNV and BRASKEM developed a methodology for risk analysis called Criticality Analysis for Hazardous Materials Transportation. The objective of this methodology is identifying the most critical points of routes to make actions to avoid accidents. (author)

  3. 49 CFR 172.328 - Cargo tanks.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Cargo tanks. 172.328 Section 172.328... SECURITY PLANS Marking § 172.328 Cargo tanks. (a) Providing and affixing identification numbers. Unless a cargo tank is already marked with the identification numbers required by this subpart,...

  4. 76 FR 32867 - Hazardous Materials: Requirements for Storage of Explosives During Transportation

    Science.gov (United States)

    2011-06-07

    ... preemptive effect of Federal hazardous materials transportation law is triggered. The commenter expresses... recommends that PHMSA ask FMCSA to strike 397.5(d)(3) and replace the condition for state and...

  5. The Cargo

    DEFF Research Database (Denmark)

    Birch, Thomas; Charlton, Michael F.; Biggs, Lynn

    2014-01-01

    The Gresham ship was carrying a substantial cargo of different metals when she sank, representing a considerable financial loss. Reports record that some of that material recovered in 1846 included 2700 tin ingots, lead pigs and iron bars (British Archaeological Association, 1847, 361). The excav...

  6. 25 CFR 170.900 - What is the purpose of the provisions relating to transportation of hazardous and nuclear waste?

    Science.gov (United States)

    2010-04-01

    ... transportation of hazardous and nuclear waste? 170.900 Section 170.900 Indians BUREAU OF INDIAN AFFAIRS... and Nuclear Waste Transportation § 170.900 What is the purpose of the provisions relating to transportation of hazardous and nuclear waste? Sections 170.900 through 170.907 on transportation of nuclear...

  7. Circular Chain Ropeway for Cargo Transportation in Mountain Citrus Orchard%山地橘园链式循环货运索道设计

    Institute of Scientific and Technical Information of China (English)

    洪添胜; 苏建; 朱余清; 杨洲; 岳学军; 宋淑然

    2011-01-01

    A circular chain cargo transportation ropeway system was proposed and developed for a simplified and labor-saving method to transport fruit and production materials in mountain citrus orchards. The ropeway system was composed of driving devices, hoisting chain, horizontal chain pulley, steering mechanism, automatic tensioning device, vertical chain pulley, combined chain pulley and cargo hooks. With the in-situ ropeway system installed in Guangdong and Jiangxi provinces, the chain circulation movement including up and down hill, steering and straight operations around the mountain was realized, fruit and production materials could be easily uploaded and downloaded by farmers standing on the ground, thereby the labor-saving and effective mountain citrus orchard cargo transportation was achieved.%为解决山地橘园的果品和农资等轻简化和省力化运送问题,提出了一种链式循环货运索道技术.该索道由驱动装置、起重链索、支架、水平托索机构、转向机构、自动张紧机构、垂直托索机构、组合托索机构和物品挂钩等组成.在广东省龙门县和江西省安远县的山地橘园实地安装此索道,链索实现了上下坡、转弯和直线的循环运行,果农站在地面可随意上载或下卸物品,最高生产率可达6.8t/h,实现了山地橘园物品省力和有效运送的目的.

  8. 78 FR 1101 - Hazardous Materials: Harmonization With the United Nations Recommendations on the Transport of...

    Science.gov (United States)

    2013-01-07

    ... 178 RIN 2137-AE83 Hazardous Materials: Harmonization With the United Nations Recommendations on the... Regulations), and the United Nations Recommendations on the Transport of Dangerous Goods: Model Regulations... a Department of Transportation (DOT) or United Nations (UN) standard packaging. Most...

  9. Investigation of Convective Downburst Hazards to Marine Transportation

    OpenAIRE

    2007-01-01

    Convective downbursts are known to produce potentially hazardous weather conditions. Currently, severity indices are used to estimate the strength of a potential downburst, but this information does not readily translate to the variables affected by downburst events. The effects of downbursts are often associated with aviation because of rapid changes in wind direction and speed, but can also be observed in marine conditions. Three recently observed downburst events have been selected as case...

  10. Individual risk evaluation and interventions for mitigation in the transportation of hazardous goods: a case study

    Directory of Open Access Journals (Sweden)

    Rada Elena Cristina

    2017-01-01

    Full Text Available The transport of hazardous substances is an economic activity essential for goods’ transference chain. However, the risk in transporting hazardous materials is related to the occur of accidents causing environmental damages and public health dangerous consequences. A quite recent Italian example is the Viareggio accident (2010, which involved a train with tank cars containing liquefied petroleum gas (LPG which caused more than thirty deaths. This paper describes the safety state in the Varese district (an area of northern Italy with a very high population density and industrial activities, with the aim at comparing the current situation (considering the risks due to the transportation of hazardous materials on the main motorways and main national roads with a potential scenario that introduces a few mitigating interventions, such as a partial conversion from road haulage to rail transport. This comparison can be accomplished by developing the existing intermodal platforms and implementing new ones in strategic areas.

  11. 77 FR 37961 - Hazardous Materials: Incorporating Rail Special Permits Into the Hazardous Materials Regulations

    Science.gov (United States)

    2012-06-25

    ... From the Federal Register Online via the Government Publishing Office ] Vol. 77 Monday, No. 122 June 25, 2012 Part II Department of Transportation Pipeline and Hazardous Materials Safety... ``conceal the presence of high value cargoes that might be the target of piracy or hijacking...

  12. Deflagration accident risk analysis of Tianjin harbor hazardous materials consolidation and distribution transportation%天津港危化品公路集疏运爆燃事故风险分析

    Institute of Scientific and Technical Information of China (English)

    王仲珏; 王绪亭; 何志

    2015-01-01

    天津港危化品大部分通过疏港公路运输。在运输过程中,由于疏港公路交通流量密集、各种车辆混行,在恶劣天气状况下,可能发生危化品车辆碰撞,导致危化品泄漏,进而发生爆燃,造成大规模的群死群伤事件。通过测算天津港主要疏港公路——海滨大道现有交通流量,模拟主要危化品车辆发生碰撞后的爆炸半径以及可能的人员伤亡损失情况,对天津港危化品公路运输爆燃风险做出定量分析。模拟结果表明,爆燃事件一旦发生,将有至少2人死亡。%In Tianjin port, most hazardous cargos are transported by consolidation and distribution road. It is likely to cause serious personnel dead and injured in a crash involving hazardous cargo truck on consolidation and distribution road due to dense traffic flow, mixture of various vehicles and bad weather condition. The traffic flow of Haibin Road, which is the main consolidation and distribution road of Tianjin harbor, was calculated. The deflagra⁃tion radiuses of main hazardous cargo were also calculated. Transportation risk of hazardous materials was analyzed quantitatively. The simulation results show that at least 2 people will be killed if deflagration happens.

  13. 46 CFR 148.03-7 - During transport.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false During transport. 148.03-7 Section 148.03-7 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) DANGEROUS CARGOES CARRIAGE OF SOLID HAZARDOUS MATERIALS IN BULK Minimum Transportation Requirements § 148.03-7 During transport. During the transport of...

  14. 46 CFR 153.283 - Valving for cargo piping.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Valving for cargo piping. 153.283 Section 153.283... CARRYING BULK LIQUID, LIQUEFIED GAS, OR COMPRESSED GAS HAZARDOUS MATERIALS Design and Equipment Piping Systems and Cargo Handling Equipment § 153.283 Valving for cargo piping. (a) Except as described in...

  15. 46 CFR 151.15-10 - Cargo gauging devices.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Cargo gauging devices. 151.15-10 Section 151.15-10... CARRYING BULK LIQUID HAZARDOUS MATERIAL CARGOES Tanks § 151.15-10 Cargo gauging devices. This section contains definitions and requirements for types of gauging devices specified in Table 151.05. (a)...

  16. 46 CFR 153.972 - Connecting a cargo hose.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Connecting a cargo hose. 153.972 Section 153.972 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES SHIPS CARRYING BULK LIQUID, LIQUEFIED GAS, OR COMPRESSED GAS HAZARDOUS MATERIALS Operations Cargo...

  17. 46 CFR 151.25-2 - Cargo handling space.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Cargo handling space. 151.25-2 Section 151.25-2 Shipping... BULK LIQUID HAZARDOUS MATERIAL CARGOES Environmental Control § 151.25-2 Cargo handling space. Pump rooms, compressor rooms, refrigeration rooms, heating rooms, instrument rooms or other closed...

  18. 49 CFR 1572.201 - Transportation of hazardous materials via commercial motor vehicle from Canada or Mexico to and...

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Transportation of hazardous materials via commercial motor vehicle from Canada or Mexico to and within the United States. 1572.201 Section 1572.201... Land Modes § 1572.201 Transportation of hazardous materials via commercial motor vehicle from Canada...

  19. 75 FR 1302 - Hazardous Materials: Transportation of Lithium Batteries

    Science.gov (United States)

    2010-01-11

    ... battery size and chemistry. The high energy density (i.e., high energy to weight ratio) of lithium... batteries are often used in medical devices, computer memory and as replaceable batteries (AA and AAA size... numbers, types, and sizes of lithium batteries moving in transportation have grown steadily in recent...

  20. 77 FR 21714 - Hazardous Materials: Transportation of Lithium Batteries

    Science.gov (United States)

    2012-04-11

    ... Aviation Organization Technical Instructions on the Transport of Dangerous Goods by Air (ICAO Technical... parts 171-180) with provisions in the ICAO Technical Instructions; other proposals in the NPRM were... the ICAO Technical Instructions. \\1\\ Flammability Assessment of Bulk-Packed, Non rechargeable...

  1. 78 FR 1119 - Hazardous Materials: Transportation of Lithium Batteries

    Science.gov (United States)

    2013-01-07

    ... Civil Aviation Organization Technical Instructions on the Transport of Dangerous Goods by Air (ICAO... and carriers to choose between compliance with the existing HMR, or compliance with the ICAO Technical... the 2013-2014 Edition of the ICAO Technical Instructions will allow each shipper and carrier to...

  2. The possibility of GIS application for the needs of planning transport of hazardous waste

    Directory of Open Access Journals (Sweden)

    Panić Milena

    2010-01-01

    Full Text Available Hazardous waste management system as a separate segment includes the transportation of hazardous waste, which specifically includes transportation from the place of its origin to the place of storage, treatment or final disposal. This function includes all forms of transport, but experience has shown that the most used one is a road traffic, which also carries an extremely high risk of possible occurrence of accident and endangering the local community, material resources and environment. Therefore, it is necessary to establish control over transport option, and the risk too, which is achieved by conducting risk assessments and then selecting the optimal transport routes. In each of these phases GIS has found its major application, enabling operation with different types of data, a simplified procedure of multi-criteria analysis and a clear visual representation of the received results. .

  3. Investigation of Convective Downburst Hazards to Marine Transportation

    CERN Document Server

    Mason, D

    2007-01-01

    Convective downbursts are known to produce potentially hazardous weather conditions. Currently, severity indices are used to estimate the strength of a potential downburst, but this information does not readily translate to the variables affected by downburst events. The effects of downbursts are often associated with aviation because of rapid changes in wind direction and speed, but can also be observed in marine conditions. Three recently observed downburst events have been selected as case studies to evaluate the effects of the downbursts on the marine environment. The information gathered on these events includes wind speed, gusts and direction at the surface, air temperature and pressure, water level, and Wet Microburst Severity Index (WMSI) values. Correlation between the WMSI values, the maximum wind gust, and the change in water level is suggested.

  4. Hazards posed by distal ash transport and sedimentation from extreme volcanic eruptions

    Science.gov (United States)

    Sahagian, D. L.; Proussevitch, A. A.; White, C. M.; Klewicki, J.

    2016-12-01

    Volcanic ash injected into the upper troposphere and lower stratosphere poses a significant hazard to aviation and human security as a result of extreme, explosive eruptions. These have occurred in the recent geologic past, and are expected to occur again, now that modern society and its infrastructure is far more vulnerable than ever before. Atmospheric transport, dispersion, and sedimentation of Ash particles is controlled by fundamentally different processes than control other particles normally transported in the atmosphere due to their complex internal and external morphology. It is thus necessary to elucidate the fundamental processes of particle-fluid interactions in the upper troposphere and lower stratosphere, where most air traffic resides, and thereby enhance the capability of volcanic ash transport models to predict the ash concentration in distal regions that pose aviation and other hazards. Current Volcanic Ash Transport and Dispersion (VATD) models use simplistic stokes settling velocities for larger ash particles, and treat smaller ash particles (that are a large part of the hazard) merely as passive tracers. By incorporating the dynamics of fine ash particle-atmosphere interactions into existing VATD models provides the foundation for a much more accurate assessment framework applied to the hazard posed by specific future extreme eruptions, and thus dramatically reduce both the risk to air traffic and the cost of airport and flight closures, in addition to human health, water quality, agricultural, infrastructure hazards, as well as ice cap albedo and short term climate impacts.

  5. Probability analysis of multiple-tank-car release incidents in railway hazardous materials transportation.

    Science.gov (United States)

    Liu, Xiang; Saat, Mohd Rapik; Barkan, Christopher P L

    2014-07-15

    Railroads play a key role in the transportation of hazardous materials in North America. Rail transport differs from highway transport in several aspects, an important one being that rail transport involves trains in which many railcars carrying hazardous materials travel together. By contrast to truck accidents, it is possible that a train accident may involve multiple hazardous materials cars derailing and releasing contents with consequently greater potential impact on human health, property and the environment. In this paper, a probabilistic model is developed to estimate the probability distribution of the number of tank cars releasing contents in a train derailment. Principal operational characteristics considered include train length, derailment speed, accident cause, position of the first car derailed, number and placement of tank cars in a train and tank car safety design. The effect of train speed, tank car safety design and tank car positions in a train were evaluated regarding the number of cars that release their contents in a derailment. This research provides insights regarding the circumstances affecting multiple-tank-car release incidents and potential strategies to reduce their occurrences. The model can be incorporated into a larger risk management framework to enable better local, regional and national safety management of hazardous materials transportation by rail. Copyright © 2014 Elsevier B.V. All rights reserved.

  6. Probability analysis of multiple-tank-car release incidents in railway hazardous materials transportation

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Xiang, E-mail: liu94@illinois.edu; Saat, Mohd Rapik, E-mail: mohdsaat@illinois.edu; Barkan, Christopher P.L., E-mail: cbarkan@illinois.edu

    2014-07-15

    Railroads play a key role in the transportation of hazardous materials in North America. Rail transport differs from highway transport in several aspects, an important one being that rail transport involves trains in which many railcars carrying hazardous materials travel together. By contrast to truck accidents, it is possible that a train accident may involve multiple hazardous materials cars derailing and releasing contents with consequently greater potential impact on human health, property and the environment. In this paper, a probabilistic model is developed to estimate the probability distribution of the number of tank cars releasing contents in a train derailment. Principal operational characteristics considered include train length, derailment speed, accident cause, position of the first car derailed, number and placement of tank cars in a train and tank car safety design. The effect of train speed, tank car safety design and tank car positions in a train were evaluated regarding the number of cars that release their contents in a derailment. This research provides insights regarding the circumstances affecting multiple-tank-car release incidents and potential strategies to reduce their occurrences. The model can be incorporated into a larger risk management framework to enable better local, regional and national safety management of hazardous materials transportation by rail.

  7. Extending natural hazard impacts: an assessment of landslide disruptions on a national road transportation network

    Science.gov (United States)

    Postance, Benjamin; Hillier, John; Dijkstra, Tom; Dixon, Neil

    2017-01-01

    Disruptions to transportation networks by natural hazard events cause direct losses (e.g. by physical damage) and indirect socio-economic losses via travel delays and decreased transportation efficiency. The severity and spatial distribution of these losses varies according to user travel demands and which links, nodes or infrastructure assets are physically disrupted. Increasing transport network resilience, for example by targeted mitigation strategies, requires the identification of the critical network segments which if disrupted would incur undesirable or unacceptable socio-economic impacts. Here, these impacts are assessed on a national road transportation network by coupling hazard data with a transport network model. This process is illustrated using a case study of landslide hazards on the road network of Scotland. A set of possible landslide-prone road segments is generated using landslide susceptibility data. The results indicate that at least 152 road segments are susceptible to landslides, which could cause indirect economic losses exceeding £35 k for each day of closure. In addition, previous estimates for historic landslide events might be significant underestimates. For example, the estimated losses for the 2007 A83 ‘Rest and Be Thankful’ landslide are £80 k day-1, totalling £1.2 million over a 15 day closure, and are ˜60% greater than previous estimates. The spatial distribution of impact to road users is communicated in terms of ‘extended hazard impact footprints’. These footprints reveal previously unknown exposed communities and unanticipated spatial patterns of severe disruption. Beyond cost-benefit analyses for landslide mitigation efforts, the approach implemented is applicable to other natural hazards (e.g. flooding), combinations of hazards, or even other network disruption events.

  8. Dry bulk cargo shipping - An overlooked threat to the marine environment?

    Science.gov (United States)

    Grote, Matthias; Mazurek, Nicole; Gräbsch, Carolin; Zeilinger, Jana; Le Floch, Stéphane; Wahrendorf, Dierk-Steffen; Höfer, Thomas

    2016-09-15

    Approximately 9.5billiontonnes of goods is transported over the world oceans annually with dry bulk representing the largest cargo group. This paper aims to analyse whether the transport and associated inputs of dry bulks into the sea create a risk for the marine environment. For this purpose, we analyse the international regulatory background concerning environmental protection (MARPOL), estimate quantities and identify inputs of such cargoes into the oceans (accidental and operational), and use available information for hazard assessment. Annually, more than 2.15milliontonnes of dry bulk cargoes are likely to enter the oceans, of which 100,000tonnes are potentially harmful to the marine environment according to the definition included in draft maritime regulation. The assessment of the threat to the marine environment is hampered by a lack of available information on chemical composition, bioavailability and toxicity. Perspectives for amendments of the unsatisfying pollution prevention regulations are discussed.

  9. Model and Method for Multiobjective Time-Dependent Hazardous Material Transportation

    Directory of Open Access Journals (Sweden)

    Zhen Zhou

    2014-01-01

    Full Text Available In most of the hazardous material transportation problems, risk factors are assumed to be constant, which ignores the fact that they can vary with time throughout the day. In this paper, we deal with a novel time-dependent hazardous material transportation problem via lane reservation, in which the dynamic nature of transportation risk in the real-life traffic environment is taken into account. We first develop a multiobjective mixed integer programming (MIP model with two conflicting objectives: minimizing the impact on the normal traffic resulting from lane reservation and minimizing the total transportation risk. We then present a cut-and-solve based ε-constraint method to solve this model. Computational results indicate that our method outperforms the ε-constraint method based on optimization software package CPLEX.

  10. Aviation safety research and transportation/hazard avoidance and elimination

    Science.gov (United States)

    Sonnenschein, C. M.; Dimarzio, C.; Clippinger, D.; Toomey, D.

    1976-01-01

    Data collected by the Scanning Laser Doppler Velocimeter System (SLDVS) was analyzed to determine the feasibility of the SLDVS for monitoring aircraft wake vortices in an airport environment. Data were collected on atmospheric vortices and analyzed. Over 1600 landings were monitored at Kennedy International Airport and by the end of the test period 95 percent of the runs with large aircraft were producing usable results in real time. The transport was determined in real time and post analysis using algorithms which performed centroids on the highest amplitude in the thresholded spectrum. Making use of other parameters of the spectrum, vortex flow fields were studied along with the time histories of peak velocities and amplitudes. The post analysis of the data was accomplished with a CDC-6700 computer using several programs developed for LDV data analysis.

  11. Identification and prioritization of hazardous material transportation strategies using DEA method

    Directory of Open Access Journals (Sweden)

    Saeid Esmaeili

    2012-09-01

    Full Text Available Development of industries needs expansion of public transportation and, consequently, heavy transportation increases hazardous and dangerous transportation too. Therefore, we need to consider some strategies to reduce bad effects of transportation of hazardous materials such as road accidents. Strength, Weakness, Opportunity and Treats (SWOT analysis is an applicable method for designing strategies in this area. However, SWOT analysis does not provide specific strategies and it does not consider the efficiency and performance of each strategy. Applying a hybrid method of analyzing the strategies and their performance evaluation help decision makers select the best strategies based on the current limitations. In this paper, different strategies for hazardous transportation risk reduction are designed and relative efficiencies of all alternatives are compared using DEA method. The proposed model of this paper uses three inputs including implementation costs, operation and maintenance cost and operational and four outputs including accident rate reduction, fuel consumption reduction, employment rate increment and deaths number reduction. The results of the implementation using seven different strategies have yielded two important strategies including continuous improvement of vehicle standards, driving skills, transportation system quality, and loading methods and expansion of petroleum pipe network.

  12. Hazard Assessment on Chlorine Distribution Use of Chemical Transportation Risk Index

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jeong Gon [Hanwha Chemical Ulsan Site, Ulsan (Korea, Republic of); Byun, Hun Soo [Chonnam National University, Yeosu (Korea, Republic of)

    2014-12-15

    Chlorine is one of the most produced and most used non-flammable chemical substances in the world even though its toxicity and high reactivity cause the ozone layer depletion. However, in modern life, it is impossible to live a good life without using Chlorine and its derivatives since they are being used as an typical ingredient in more than 40 percent of the manufactured goods including medicines, detergents, deodorant, fungicides, herbicides, insecticides, and plastic, etc. Even if Chlorine has been handled and distributed in various business (small and medium-sized businesses, water purification plants, distribution company, etc.), there have been few researches about its possible health hazard and transportation risks. Accordingly, the purpose of this paper is to make a detailed assessment of Chlorinerelated risks and to model an index of chemicals transportation risks that is adequate for domestic circumstances. The assessment of possible health hazard and transportation risks was made on 13 kinds of hazardous chemicals, including liquid chlorine. This research may be contributed to standardizing the risk assessment of Chlorine and other hazardous chemicals by using an index of transportation risks.

  13. RESEARCH ABOUT THE USERS´ PERCEPTION OF ACCOUNTING AND TAX BOOKKEEPING MODULES OF AN ERP SYSTEM FOR THE CARGO AND PASSENGERS ROAD TRANSPORTATION SECTOR

    Directory of Open Access Journals (Sweden)

    Ivam Ricardo Peleias

    2009-10-01

    Full Text Available This research evaluated the users´perception of accounting and tax bookkeeping modules of an ERP – Enterprise Resources Planning System for the cargo and passengers road transportation sector. It´s a survey research, which combined empiric investigation, bibliographical review, as well as field research. It was applied a questionnaire containing 20 questions to characterize the sample and 30 assertive ones, answered by 37 users of the system. The collected data were treated by Qualitative Analysis, Descriptive Statistics, Cluster Analysis and Comparative Analysis among the clusters. The results demonstrate how these users perceive the importance and the facilities with the use of the system, as well as grouped such users in 3 opinion clusters (optimistic, realists and pessimistic and indicated points that can be improved in the system.

  14. 49 CFR 178.320 - General requirements applicable to all DOT specification cargo tank motor vehicles.

    Science.gov (United States)

    2010-10-01

    ...) Each cargo tank or cargo tank motor vehicle design type, including its required accident damage... specification cargo tank motor vehicles. 178.320 Section 178.320 Transportation Other Regulations Relating to... Transportation § 178.320 General requirements applicable to all DOT specification cargo tank motor vehicles....

  15. Airborne biological hazards and urban transport infrastructure: current challenges and future directions.

    Science.gov (United States)

    Nasir, Zaheer Ahmad; Campos, Luiza Cintra; Christie, Nicola; Colbeck, Ian

    2016-08-01

    Exposure to airborne biological hazards in an ever expanding urban transport infrastructure and highly diverse mobile population is of growing concern, in terms of both public health and biosecurity. The existing policies and practices on design, construction and operation of these infrastructures may have severe implications for airborne disease transmission, particularly, in the event of a pandemic or intentional release of biological of agents. This paper reviews existing knowledge on airborne disease transmission in different modes of transport, highlights the factors enhancing the vulnerability of transport infrastructures to airborne disease transmission, discusses the potential protection measures and identifies the research gaps in order to build a bioresilient transport infrastructure. The unification of security and public health research, inclusion of public health security concepts at the design and planning phase, and a holistic system approach involving all the stakeholders over the life cycle of transport infrastructure hold the key to mitigate the challenges posed by biological hazards in the twenty-first century transport infrastructure.

  16. 46 CFR 154.534 - Cargo pumps and cargo compressors.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Cargo pumps and cargo compressors. 154.534 Section 154.534 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES... Equipment Cargo and Process Piping Systems § 154.534 Cargo pumps and cargo compressors. Cargo pumps...

  17. 46 CFR 154.1866 - Cargo hose connection: Transferring cargo.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Cargo hose connection: Transferring cargo. 154.1866... CARGOES SAFETY STANDARDS FOR SELF-PROPELLED VESSELS CARRYING BULK LIQUEFIED GASES Operations § 154.1866 Cargo hose connection: Transferring cargo. No person may transfer cargo through a cargo hose...

  18. Characterizing the composition of molecular motors on moving axonal cargo using "cargo mapping" analysis.

    Science.gov (United States)

    Neumann, Sylvia; Campbell, George E; Szpankowski, Lukasz; Goldstein, Lawrence S B; Encalada, Sandra E

    2014-10-30

    Understanding the mechanisms by which molecular motors coordinate their activities to transport vesicular cargoes within neurons requires the quantitative analysis of motor/cargo associations at the single vesicle level. The goal of this protocol is to use quantitative fluorescence microscopy to correlate ("map") the position and directionality of movement of live cargo to the composition and relative amounts of motors associated with the same cargo. "Cargo mapping" consists of live imaging of fluorescently labeled cargoes moving in axons cultured on microfluidic devices, followed by chemical fixation during recording of live movement, and subsequent immunofluorescence (IF) staining of the exact same axonal regions with antibodies against motors. Colocalization between cargoes and their associated motors is assessed by assigning sub-pixel position coordinates to motor and cargo channels, by fitting Gaussian functions to the diffraction-limited point spread functions representing individual fluorescent point sources. Fixed cargo and motor images are subsequently superimposed to plots of cargo movement, to "map" them to their tracked trajectories. The strength of this protocol is the combination of live and IF data to record both the transport of vesicular cargoes in live cells and to determine the motors associated to these exact same vesicles. This technique overcomes previous challenges that use biochemical methods to determine the average motor composition of purified heterogeneous bulk vesicle populations, as these methods do not reveal compositions on single moving cargoes. Furthermore, this protocol can be adapted for the analysis of other transport and/or trafficking pathways in other cell types to correlate the movement of individual intracellular structures with their protein composition. Limitations of this protocol are the relatively low throughput due to low transfection efficiencies of cultured primary neurons and a limited field of view available for

  19. 49 CFR 173.318 - Cryogenic liquids in cargo tanks.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Cryogenic liquids in cargo tanks. 173.318 Section... REQUIREMENTS FOR SHIPMENTS AND PACKAGINGS Gases; Preparation and Packaging § 173.318 Cryogenic liquids in cargo tanks. (a) General requirements. (1) A cargo tank may not be loaded with a cryogenic liquid colder than...

  20. 49 CFR 176.39 - Inspection of cargo.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Inspection of cargo. 176.39 Section 176.39... Requirements § 176.39 Inspection of cargo. (a) Manned vessels. The carrier, its agents, and any person... thereafter, weather permitting, in order to ensure that the cargo is in a safe condition and that no...

  1. NASA Constellation Program (CxP) Key Driving Requirements and Element Descriptions for International Architecture Working Group (IAWG) Functional Teams Human Transportation Cargo Transportation

    Science.gov (United States)

    Martinez, Roland M.

    2009-01-01

    The NASA Constellation uncrewed cargo mission delivers cargo to any designated location on the lunar surface (or other staging point) in a single mission. This capability is used to deliver surface infrastructure needed for lunar outpost construction, to provide periodic logistics resupply to support a continuous human lunar presence, and potentially deliver other assets to various locations.In the nominal mission mode, the Altair lunar lander is launched on Ares V into Low Earth Orbit (LEO), following a short Low Earth Orbit (LEO) loiter period, the Earth Departure Stage (EDS) performs the Trans Lunar Injection (TLI) burn and is then jettisoned. The Altair performs translunar trajectory correction maneuvers as necessary and performs the Lunar Orbit Insertion (LOI) burn. Altair then descends to the surface to land near a designated target, presumably in proximity to an Outpost location or another site of interest for exploration.Alternatively, the EDS and Altair Descent Stage could deliver assets to various staging points within their propulsive capabilities.

  2. Emergency response network design for hazardous materials transportation with uncertain demand

    Directory of Open Access Journals (Sweden)

    Kamran Shahanaghi

    2012-10-01

    Full Text Available Transportation of hazardous materials play an essential role on keeping a friendly environment. Every day, a substantial amount of hazardous materials (hazmats, such as flammable liquids and poisonous gases, need to be transferred prior to consumption or disposal. Such transportation may result in unsuitable events for people and environment. Emergency response network is designed for this reason where specialist responding teams resolve any issue as quickly as possible. This study proposes a new multi-objective model to locate emergency response centers for transporting the hazardous materials. Since many real-world applications are faced with uncertainty in input parameters, the proposed model of this paper also assumes that reference and demand to such centre is subject to uncertainty, where demand is fuzzy random. The resulted problem formulation is modelled as nonlinear non-convex mixed integer programming and we used NSGAII method to solve the resulted problem. The performance of the proposed model is examined with several examples using various probability distribution and they are compared with the performance of other existing method.

  3. Telematics for hazardous goods transportation; Anwendungen fuer den Transport von kritischen Guetern

    Energy Technology Data Exchange (ETDEWEB)

    Stingl, D. [Danzas Logistics GmbH, Hamburg (Germany)

    1999-07-01

    In the course of the integration of the customer Langnese Iglo in autumn 1997 and in view of the already existing general conditions for the implementation of the equlations of the directive on food hygiene (HACCP-concept) as well as the permanently in reasing demand for quality of logistics DANZAS Logistics GmbH, cooperating closely with in deep-frozen goods customer Langnese-Iglo decided to develop a new system of quality assurance for the transportation of deep-frozen goods and apply this system to all its activities. First ideas about standard demands, technical solutions and multi-functional design showed that the project had to be handled in such a flexible way that temperature controlling (for the transportation of deep-frozen goods, temperature-controlled DANZAS-warehouses and all future temperature-controlled transportation) and the monitoring of security-relevant transportation can be integrated in one and the same project. (orig.) [German] Im Zuge der Integration des Kunden Langnese Iglo im Herbst 1997 und unter Beruecksichtigung der bereits vorliegenden Rahmenbedingungen zur Umsetzung der Bestimmungen der Lebensmittelhygieneverordnung (HACCP-Konzept) sowie des staendig wachsenden Qualitaetsanspruches an logistische Dienstleistungen, hat sich die DANZAS Logistics GmbH in enger Zusammenarbeit mit dem TK-Kunden Langnese Iglo entschlossen, ein innovatives System zur Qualitaetssicherung im Tiefkuehltransport zu erarbeiten und flaechendeckend einzusetzen. Die ersten Gedanken bezueglich Standardanforderungen, technischer Loesungsansaetze und multifunktionaler Ausrichtung zeigten, dass dieses Projekt so variabel zu gestalten ist, dass sowohl Temperaturcontrolling (fuer TK-Transporte, fuer die temperaturgefuehrten DANZAS-Laeger und zukuenftig alle temperaturgefuehrten Transporte) als auch die Ueberwachung sicherheitsrelevanter Transporte zu integrieren sind. (orig.)

  4. Evaluation of a self-guided transport vehicle for remote transportation of transuranic and other hazardous waste

    Energy Technology Data Exchange (ETDEWEB)

    Rice, P.M.; Moody, S.J.; Peterson, R. [and others

    1997-04-01

    Between 1952 and 1970, over two million cubic ft of transuranic mixed waste was buried in shallow pits and trenches in the Subsurface Disposal Area at the Idaho National Engineering Laboratory`s Radioactive Waste Management Complex. Commingled with this two million cubic ft of waste is up to 10 million cubic ft of fill soil. The pits and trenches were constructed similarly to municipal landfills with both stacked and random dump waste forms such as barrels and boxes. The main contaminants are micron-sized particles of plutonium and americium oxides, chlorides, and hydroxides. Retrieval, treatment, and disposal is one of the options being considered for the waste. This report describes the results of a field demonstration conducted to evaluate a technology for transporting exhumed transuranic wastes at the Idaho National Engineering and Environmental Laboratory (INEEL) and at other hazardous or radioactive waste sites through the U.S. Department of Energy complex. The full-scale demonstration, conducted at the INEEL Robotics Center in the summer of 1995, evaluated equipment performance and techniques for remote transport of exhumed buried waste. The technology consisted of a Self-Guided Transport Vehicle designed to remotely convey retrieved waste from the retrieval digface and transport it to a receiving/processing area with minimal human intervention. Data were gathered and analyzed to evaluate performance parameters such as precision and accuracy of navigation and transportation rates.

  5. Fuzzy multi-objective chance-constrained programming model for hazardous materials transportation

    Science.gov (United States)

    Du, Jiaoman; Yu, Lean; Li, Xiang

    2016-04-01

    Hazardous materials transportation is an important and hot issue of public safety. Based on the shortest path model, this paper presents a fuzzy multi-objective programming model that minimizes the transportation risk to life, travel time and fuel consumption. First, we present the risk model, travel time model and fuel consumption model. Furthermore, we formulate a chance-constrained programming model within the framework of credibility theory, in which the lengths of arcs in the transportation network are assumed to be fuzzy variables. A hybrid intelligent algorithm integrating fuzzy simulation and genetic algorithm is designed for finding a satisfactory solution. Finally, some numerical examples are given to demonstrate the efficiency of the proposed model and algorithm.

  6. An overview of natural hazard impacts to railways and urban transportation systems

    Science.gov (United States)

    Bíl, Michal; Nezval, Vojtěch; Bílová, Martina; Andrášik, Richard; Kubeček, Jan

    2017-04-01

    We present an overview and two case studies of natural hazard impacts on rail transportation systems in the Czech Republic. Flooding, landsliding, heavy snowfall, windstorms and glaze (black ice) are the most common natural processes which occur in this region. Whereas flooding and landsliding usually cause direct damage to the transportation infrastructure, other hazards predominantly cause indirect losses. Railway and urban tramline networks are almost fully dependent on electricity which is provided by a system of overhead lines (electric lines above the tracks). These lines are extremely susceptible to formation of glaze which blocks conduction of electric current. A December 2014 glaze event caused significant indirect losses in the largest Czech cities and railways due to the above-mentioned process. Details of this event will be provided during the presentation. Windstorms usually cause tree falls which can affect overhead lines and physically block railway tracks. Approximately 30 % of the Czech railway network is closer than 50 m from the nearest forest. This presents significant potential for transport interruption due to falling trees. Complicated legal relations among the owners of the plots of land along railways, the environment (full-grown trees and related habitat), and the railway administrator are behind many traffic interruptions due to falling trees. We have registered 2040 tree falls between 2012 and 2015 on the railway network. A model of the fallen tree hazard was created for the entire Czech railway network. Both above-mentioned case studies provide illustrative examples of the increased fragility of the modern transportation systems which fully rely on electricity. Natural processes with a low destructive power are thereby able to cause network wide service cut-offs.

  7. 49 CFR 178.347 - Specification DOT 407; cargo tank motor vehicle.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Specification DOT 407; cargo tank motor vehicle... SPECIFICATIONS FOR PACKAGINGS Specifications for Containers for Motor Vehicle Transportation § 178.347 Specification DOT 407; cargo tank motor vehicle....

  8. 49 CFR 178.346 - Specification DOT 406; cargo tank motor vehicle.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Specification DOT 406; cargo tank motor vehicle... SPECIFICATIONS FOR PACKAGINGS Specifications for Containers for Motor Vehicle Transportation § 178.346 Specification DOT 406; cargo tank motor vehicle....

  9. 49 CFR 178.348 - Specification DOT 412; cargo tank motor vehicle.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Specification DOT 412; cargo tank motor vehicle... SPECIFICATIONS FOR PACKAGINGS Specifications for Containers for Motor Vehicle Transportation § 178.348 Specification DOT 412; cargo tank motor vehicle....

  10. Cargo recognition and cargo-mediated regulation of unconventional myosins.

    Science.gov (United States)

    Lu, Qing; Li, Jianchao; Zhang, Mingjie

    2014-10-21

    Organized motions are hallmarks of living organisms. Such motions range from collective cell movements during development and muscle contractions at the macroscopic scale all the way down to cellular cargo (e.g., various biomolecules and organelles) transportation and mechanoforce sensing at more microscopic scales. Energy required for these biological motions is almost invariably provided by cellular chemical fuels in the form of nucleotide triphosphate. Biological systems have designed a group of nanoscale engines, known as molecular motors, to convert cellular chemical fuels into mechanical energy. Molecular motors come in various forms including cytoskeleton motors (myosin, kinesin, and dynein), nucleic-acid-based motors, cellular membrane-based rotary motors, and so on. The main focus of this Account is one subfamily of actin filament-based motors called unconventional myosins (other than muscle myosin II, the remaining myosins are collectively referred to as unconventional myosins). In general, myosins can use ATP to fuel two types of mechanomotions: dynamic tethering actin filaments with various cellular compartments or structures and actin filament-based intracellular transport. In contrast to rich knowledge accumulated over many decades on ATP hydrolyzing motor heads and their interactions with actin filaments, how various myosins recognize their specific cargoes and whether and how cargoes can in return regulate functions of motors are less understood. Nonetheless, a series of biochemical and structural investigations in the past few years, including works from our own laboratory, begin to shed lights on these latter questions. Some myosins (e.g., myosin-VI) can function both as cellular transporters and as mechanical tethers. To function as a processive transporter, myosins need to form dimers or multimers. To be a mechanical tether, a monomeric myosin is sufficient. It has been shown for myosin-VI that its cellular cargo proteins can play critical roles

  11. Automating Risk Assessments of Hazardous Material Shipments for Transportation Routes and Mode Selection

    Energy Technology Data Exchange (ETDEWEB)

    Barbara H. Dolphin; William D. RIchins; Stephen R. Novascone

    2010-10-01

    The METEOR project at Idaho National Laboratory (INL) successfully addresses the difficult problem in risk assessment analyses of combining the results from bounding deterministic simulation results with probabilistic (Monte Carlo) risk assessment techniques. This paper describes a software suite designed to perform sensitivity and cost/benefit analyses on selected transportation routes and vehicles to minimize risk associated with the shipment of hazardous materials. METEOR uses Monte Carlo techniques to estimate the probability of an accidental release of a hazardous substance along a proposed transportation route. A METEOR user selects the mode of transportation, origin and destination points, and charts the route using interactive graphics. Inputs to METEOR (many selections built in) include crash rates for the specific aircraft, soil/rock type and population densities over the proposed route, and bounding limits for potential accident types (velocity, temperature, etc.). New vehicle, materials, and location data are added when available. If the risk estimates are unacceptable, the risks associated with alternate transportation modes or routes can be quickly evaluated and compared. Systematic optimizing methods will provide the user with the route and vehicle selection identified with the lowest risk of hazardous material release. The effects of a selected range of potential accidents such as vehicle impact, fire, fuel explosions, excessive containment pressure, flooding, etc. are evaluated primarily using hydrocodes capable of accurately simulating the material response of critical containment components. Bounding conditions that represent credible accidents (i.e; for an impact event, velocity, orientations, and soil conditions) are used as input parameters to the hydrocode models yielding correlation functions relating accident parameters to component damage. The Monte Carlo algorithms use random number generators to make selections at the various decision

  12. Radioactive and hazardous materials transportation: What local officials are telling us

    Energy Technology Data Exchange (ETDEWEB)

    Walker, J. A.; Ruberg, G. E. [Virginia Polytechnic Inst. and State Univ., Blacksburg, VA (USA). Management Systems Labs.; Denny, S. H. [USDOE Assistant Secretary for Defense Programs, Washington, DC (USA). Transportation Management Div.

    1990-01-01

    This paper summarizes the results of a 1989 interactive meeting of US Department of Energy (DOE) representatives with over twenty local government officials from cities and counties around the country. Management Systems Laboratories of Virginia Tech, in coordination with the Energy Task Force Management Corporation (now called the Urban Energy Transportation Corporation), designed and facilitated the meeting with these goals: Share information that local government officials can apply to their own communities; exchange experiences and ideas applicable to other emergency management programs; and identify areas of productive action for DOE and local government to address issues of mutual concern. The highlight of the meeting was a Program Planning Exercise. The participants, playing the roles of federal managers in DOE, developed programs to address the concerns of local governments on the subjects of transportation of hazardous and nuclear materials, and emergency preparedness related to incidents involving shipments of those materials.

  13. OPTIMAL GOODS STOWAGE IN AIR CARGO TERMINALS

    Directory of Open Access Journals (Sweden)

    Gennadiy Yun

    2011-03-01

    Full Text Available Abstract. Lack of system research done by domestic and foreign scientists in the field of optimal cargostraffic distribution problem in Air Cargo Terminal, proves necessity of investigation and optimization of thisprocess. Mathematical models and algorithms of optimal problem solving for air cargos distribution inwarehouses on the basis of established functional dependence between freight flow stowage in warehousesand transport vehicle loading (unloading processes are presented in the article.Keywords:algorithms, dimensions of air cargo terminal, effectiveness of loading-unloading processes,freight flow, models.

  14. OPTIMAL GOODS STOWAGE IN AIR CARGO TERMINALS

    OpenAIRE

    Yun, Gennadiy; Gyrych, Victoria

    2011-01-01

    Abstract. Lack of system research done by domestic and foreign scientists in the field of optimal cargostraffic distribution problem in Air Cargo Terminal, proves necessity of investigation and optimization of thisprocess. Mathematical models and algorithms of optimal problem solving for air cargos distribution inwarehouses on the basis of established functional dependence between freight flow stowage in warehousesand transport vehicle loading (unloading) processes are presented in the articl...

  15. 49 CFR 175.78 - Stowage compatibility of cargo.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Stowage compatibility of cargo. 175.78 Section 175... Loading, Unloading and Handling § 175.78 Stowage compatibility of cargo. (a) For stowage on an aircraft..., Compatibility Group S, explosives are permitted to be transported aboard a passenger aircraft. Only...

  16. Risk Analysis of Marine Steel Cargo Transportation and Safety Management Countermeasures%钢材货物水上运输风险分析及安全管理对策

    Institute of Scientific and Technical Information of China (English)

    马晓雪; 李文华; 张俊; 乔卫亮; 张超

    2012-01-01

    With the focus on the frequent occurrence of accidents of steel cargo carrying ships, the characteristics of steel cargo are summarized and the factors influencing the safety of steel cargo transportation at sea are analyzed. All factors related to the risk are found out from the transport process of steel cargo by using the fishbone diagram method. Nine fatal accidents of carrying steel ships from 2007 to 2011 are counted and their accident occurrence regularity is obtained by a correlation degree calculation. According to the analysis results of the risk factors and accident occurrence regularity, some practical safety management measures are put forth for the main bodies of related responsibilities.%针对当前载运钢材船舶事故多发的态势,总结钢材货物的特点,分析钢材货物水上运输安全的影响因素.采用鱼刺图根据影响因素从钢材货物水上运输流程中找出每个风险因素.同时统计2007-2011的9起载运钢材货物船舶重大事故,并通过相关度计算得出事故发生规律.最后根据风险因素和事故统计分析结果,从相关责任主体方面提出具体的安全管理措施.

  17. Flex Cargo Rail. Developing new service, collection and distribution concepts for the transport of freight by rail.; Flex Cargo Rail. Wege zu neuen Bedien-, Sammel- und Verteilkonzepten im Schienengueterverkehr

    Energy Technology Data Exchange (ETDEWEB)

    Kochsiek, Joachim [Fraunhofer-Institut fuer Materialfluss und Logistik (IML), Dortmund (Germany). Gruppe Multimodale Logistik

    2010-07-01

    FlexCargoRail is a concept for self propelled electric freight wagons. This will enhance rail operations on first and last mile. The concept can be integrated in the existing rail system, so migration is possible without any lost investments. Standard components from industry and rail are used to realise the FCR wagon. Motors, transmissions, control and batteries are available and approved. One of the effects is to enhance service for loading terminals. This can become independent from factory siding operation. From the economic point of view, FCR is realisable. This is shown by target costing. Efficiency of FCR is dependent from high frequent use of FCR rail cars and the use of the possibility to shunt also conventional freight wagons with FCR wagons. Migration should be carried out in logistical networks with frequent operations between plants and sidings with a closed wagon pool. (orig.)

  18. Linking molecular motors to membrane cargo

    NARCIS (Netherlands)

    A.S. Akhmanova (Anna); J.A. Hammer (John)

    2010-01-01

    textabstractThree types of motors, myosins, kinesins, and cytoplasmic dynein, cooperate to transport intracellular membrane organelles. Transport of each cargo is determined by recruitment of specific sets of motors and their regulation. Targeting of motors to membranes often depends on the formatio

  19. Engineering monitoring of rockfall hazards along transportation corridors: using mobile terrestrial LiDAR

    Directory of Open Access Journals (Sweden)

    M. Lato

    2009-06-01

    Full Text Available Geotechnical hazards along linear transportation corridors are challenging to identify and often require constant monitoring. Inspecting corridors using traditional, manual methods requires the engineer to be unnecessarily exposed to the hazard. It also requires closure of the corridor to ensure safety of the worker from passing vehicles. This paper identifies the use of mobile terrestrial LiDAR data as a compliment to traditional field methods. Mobile terrestrial LiDAR is an emerging remote data collection technique capable of generating accurate fully three-dimensional virtual models while driving at speeds up to 100 km/h. Data is collected from a truck that causes no delays to active traffic nor does it impede corridor use. These resultant georeferenced data can be used for geomechanical structural feature identification and kinematic analysis, rockfall path identification and differential monitoring of rock movement or failure over time. Comparisons between mobile terrestrial and static LiDAR data collection and analysis are presented. As well, detailed discussions on workflow procedures for possible implementation are discussed. Future use of mobile terrestrial LiDAR data for corridor analysis will focus on repeated surveys and developing dynamic four-dimensional models, higher resolution data collection. As well, computationally advanced, spatially accurate, geomechanically controlled three-dimensional rockfall simulations should be investigated.

  20. Risk assessment framework of fate and transport models applied to hazardous waste sites

    Energy Technology Data Exchange (ETDEWEB)

    Hwang, S.T.

    1993-06-01

    Risk assessment is an increasingly important part of the decision-making process in the cleanup of hazardous waste sites. Despite guidelines from regulatory agencies and considerable research efforts to reduce uncertainties in risk assessments, there are still many issues unanswered. This paper presents new research results pertaining to fate and transport models, which will be useful in estimating exposure concentrations and will help reduce uncertainties in risk assessment. These developments include an approach for (1) estimating the degree of emissions and concentration levels of volatile pollutants during the use of contaminated water, (2) absorption of organic chemicals in the soil matrix through the skin, and (3) steady state, near-field, contaminant concentrations in the aquifer within a waste boundary.

  1. Selecting the minimum risk route in the transportation of hazardous materials

    Directory of Open Access Journals (Sweden)

    Marijan Žura

    1992-12-01

    Full Text Available The transportation of hazardous materials is a broad and complex topic. Percent and iveight of accidents of vehicles carrying dangerous goods are growing fast. Modern computer based information system for dangerous materials management is becoming more and more important. In this paper I present an interactive software system for minimum risk route selection based on the PC ARC/INFO. The model computes optimal path based on accident probability is computed from traffic accident rates, highway operational speed, traffic volume and technical characteristic of the roadwidth, radius and slope. Dangerous goods are classified into nine classes according to their impact to different sensible environment elements. Those sensible elements are drinking water resourses, natural heritage, forestry, agricultural areas, cultural heritage, urban areas and tourist resorts. Some results of system implementation on Slovenia road network are be presented.

  2. 77 FR 21577 - Agency Information Collection Activities: Cargo Container and Road Vehicle Certification for...

    Science.gov (United States)

    2012-04-10

    ... SECURITY U.S. Customs and Border Protection Agency Information Collection Activities: Cargo Container and... collection requirement concerning the Cargo Container and Road Vehicle for Transport under Customs Seal. This...: Title: Cargo Container and Road Vehicle for Transport under Customs Seal. OMB Number: 1651-0124....

  3. Smart Collision Avoidance and Hazard Routing Mechanism for Intelligent Transport Network

    Science.gov (United States)

    Singh, Gurpreet; Gupta, Pooja; Wahab, Mohd Helmy Abd

    2017-08-01

    The smart vehicular ad-hoc network is the network that consists of vehicles for smooth movement and better management of the vehicular connectivity across the given network. This research paper aims to propose a set of solution for the VANETs consisting of the automatic driven vehicles, also called as the autonomous car. Such vehicular networks are always prone to collision due to the natural or un-natural reasons which must be solved before the large-scale deployment of the autonomous transport systems. The newly designed intelligent transport movement control mechanism is based upon the intelligent data propagation along with the vehicle collision and traffic jam prevention schema [8], which may help the future designs of smart cities to become more robust and less error-prone. In the proposed model, the focus is on designing a new dynamic and robust hazard routing protocol for intelligent vehicular networks for improvement of the overall performance in various aspects. It is expected to improve the overall transmission delay as well as the number of collisions or adversaries across the vehicular network zone.

  4. Niemann-Pick C1 Functions Independently of Niemann-Pick C2 in the Initial Stage of Retrograde Transport of Membrane-impermeable Lysosomal Cargo*

    Science.gov (United States)

    Goldman, Stephen D. B.; Krise, Jeffrey P.

    2010-01-01

    The rare neurodegenerative disease Niemann-Pick Type C (NPC) results from mutations in either NPC1 or NPC2, which are membrane-bound and soluble lysosomal proteins, respectively. Previous studies have shown that mutations in either protein result in biochemically indistinguishable phenotypes, most notably the hyper-accumulation of cholesterol and other cargo in lysosomes. We comparatively evaluated the kinetics of [3H]dextran release from lysosomes of wild type, NPC1, NPC2, and NPC1/NPC2 pseudo-double mutant cells and found significant differences between all cell types examined. Specifically, NPC1 or NPC2 mutant fibroblasts treated with NPC1 or NPC2 siRNA (to create NPC1/NPC2 pseudo-double mutants) secreted dextran less efficiently than did either NPC1 or NPC2 single mutant cell lines, suggesting that the two proteins may work independently of one another in the egress of membrane-impermeable lysosomal cargo. To investigate the basis for these differences, we examined the role of NPC1 and NPC2 in the retrograde fusion of lysosomes with late endosomes to create so-called hybrid organelles, which is believed to be the initial step in the egress of cargo from lysosomes. We show here that cells with mutated NPC1 have significantly reduced rates of late endosome/lysosome fusion relative to wild type cells, whereas cells with mutations in NPC2 have rates that are similar to those observed in wild type cells. Instead of being involved in hybrid organelle formation, we show that NPC2 is required for efficient membrane fission events from nascent hybrid organelles, which is thought to be required for the reformation of lysosomes and the release of lysosomal cargo-containing membrane vesicles. Collectively, these results suggest that NPC1 and NPC2 can function independently of one another in the egress of certain membrane-impermeable lysosomal cargo. PMID:20007703

  5. Niemann-Pick C1 functions independently of Niemann-Pick C2 in the initial stage of retrograde transport of membrane-impermeable lysosomal cargo.

    Science.gov (United States)

    Goldman, Stephen D B; Krise, Jeffrey P

    2010-02-12

    The rare neurodegenerative disease Niemann-Pick Type C (NPC) results from mutations in either NPC1 or NPC2, which are membrane-bound and soluble lysosomal proteins, respectively. Previous studies have shown that mutations in either protein result in biochemically indistinguishable phenotypes, most notably the hyper-accumulation of cholesterol and other cargo in lysosomes. We comparatively evaluated the kinetics of [(3)H]dextran release from lysosomes of wild type, NPC1, NPC2, and NPC1/NPC2 pseudo-double mutant cells and found significant differences between all cell types examined. Specifically, NPC1 or NPC2 mutant fibroblasts treated with NPC1 or NPC2 siRNA (to create NPC1/NPC2 pseudo-double mutants) secreted dextran less efficiently than did either NPC1 or NPC2 single mutant cell lines, suggesting that the two proteins may work independently of one another in the egress of membrane-impermeable lysosomal cargo. To investigate the basis for these differences, we examined the role of NPC1 and NPC2 in the retrograde fusion of lysosomes with late endosomes to create so-called hybrid organelles, which is believed to be the initial step in the egress of cargo from lysosomes. We show here that cells with mutated NPC1 have significantly reduced rates of late endosome/lysosome fusion relative to wild type cells, whereas cells with mutations in NPC2 have rates that are similar to those observed in wild type cells. Instead of being involved in hybrid organelle formation, we show that NPC2 is required for efficient membrane fission events from nascent hybrid organelles, which is thought to be required for the reformation of lysosomes and the release of lysosomal cargo-containing membrane vesicles. Collectively, these results suggest that NPC1 and NPC2 can function independently of one another in the egress of certain membrane-impermeable lysosomal cargo.

  6. Multipurpose Cargo Transfer Bag

    Science.gov (United States)

    Broyan, James; Baccus, Shelley

    2014-01-01

    The Logistics Reduction (LR) project within the Advanced Exploration Systems (AES) program is tasked with reducing logistical mass and repurposing logistical items. Multipurpose Cargo Transfer Bags (MCTB) have been designed such that they can serve the same purpose as a Cargo Transfer Bag, the suitcase-shaped common logistics carrying bag for Shuttle and the International Space Station. After use as a cargo carrier, a regular CTB becomes trash, whereas the MCTB can be unzipped, unsnapped, and unfolded to be reused. Reuse ideas that have been investigated include partitions, crew quarters, solar radiation storm shelters, acoustic blankets, and forward osmosis water processing.

  7. 76 FR 41278 - Cargo Security Risk Reduction; Public Listening Sessions

    Science.gov (United States)

    2011-07-13

    ... SECURITY Coast Guard Cargo Security Risk Reduction; Public Listening Sessions AGENCY: Coast Guard, DHS..., transfer, and storage of Certain Dangerous Cargo (CDC) in bulk within the U.S. Marine Transportation System....Bergan@uscg.mil . SUPPLEMENTARY INFORMATION: Background In September 2009, the Coast Guard held a...

  8. Financial assistance to States and tribes to support emergency preparedness and response and the safe transportation of hazardous shipments

    Energy Technology Data Exchange (ETDEWEB)

    Bradbury, J.A.; Jones, M.L.

    1995-01-01

    This report identifies and summarizes existing sources of financial assistance to States and Indian tribes in preparing and responding to transportation emergencies and ensuring the safe transportation of hazardous shipments through their jurisdictions. The report has been prepared as an information resource for the US Department of Energy`s Office of Environmental Restoration and Waste Management, Office of Transportation, Emergency Management and Analytical Services. The report discusses funding programs administered by the following Federal agencies: Federal Emergency Management Agency; Department of Transportation; the Environmental Protection Agency; and the Department of Energy. Also included is a summary of fees assessed by some States on carriers of hazardous materials and hazardous waste. The discussion of programs is supplemented by an Appendix that provides a series of tables summarizing funding sources and amounts. The report includes several conclusions concerning the level of funding provided to Indian tribes, the relative ranking of funding sources and the variation among States in overall revenues for emergency response and safe transportation.

  9. A mechanism for retromer endosomal coat complex assembly with cargo.

    Science.gov (United States)

    Harrison, Megan S; Hung, Chia-Sui; Liu, Ting-ting; Christiano, Romain; Walther, Tobias C; Burd, Christopher G

    2014-01-07

    Retromer is an evolutionarily conserved protein complex composed of the VPS26, VPS29, and VPS35 proteins that selects and packages cargo proteins into transport carriers that export cargo from the endosome. The mechanisms by which retromer is recruited to the endosome and captures cargo are unknown. We show that membrane recruitment of retromer is mediated by bivalent recognition of an effector of PI3K, SNX3, and the RAB7A GTPase, by the VPS35 retromer subunit. These bivalent interactions prime retromer to capture integral membrane cargo, which enhances membrane association of retromer and initiates cargo sorting. The role of RAB7A is severely impaired by a mutation, K157N, that causes Charcot-Marie-Tooth neuropathy 2B. The results elucidate minimal requirements for retromer assembly on the endosome membrane and reveal how PI3K and RAB signaling are coupled to initiate retromer-mediated cargo export.

  10. Variable neighborhood search to solve the vehicle routing problem for hazardous materials transportation.

    Science.gov (United States)

    Bula, Gustavo Alfredo; Prodhon, Caroline; Gonzalez, Fabio Augusto; Afsar, H Murat; Velasco, Nubia

    2017-02-15

    This work focuses on the Heterogeneous Fleet Vehicle Routing problem (HFVRP) in the context of hazardous materials (HazMat) transportation. The objective is to determine a set of routes that minimizes the total expected routing risk. This is a nonlinear function, and it depends on the vehicle load and the population exposed when an incident occurs. Thus, a piecewise linear approximation is used to estimate it. For solving the problem, a variant of the Variable Neighborhood Search (VNS) algorithm is employed. To improve its performance, a post-optimization procedure is implemented via a Set Partitioning (SP) problem. The SP is solved on a pool of routes obtained from executions of the local search procedure embedded on the VNS. The algorithm is tested on two sets of HFVRP instances based on literature with up to 100 nodes, these instances are modified to include vehicle and arc risk parameters. The results are competitive in terms of computational efficiency and quality attested by a comparison with Mixed Integer Linear Programming (MILP) previously proposed.

  11. Analysis on Topological Properties of Dalian Hazardous Materials Road Transportation Network

    Directory of Open Access Journals (Sweden)

    Pengyun Chong

    2015-01-01

    Full Text Available To analyze the topological properties of hazardous materials road transportation network (HMRTN, this paper proposed two different ways to construct the cyberspace of HMRTN and constructed their complex network models, respectively. One was the physical network model of HMRTN based on the primal approach and the other was the service network model of HMRTN based on neighboring nodes. The two complex network models were built by using the case of Dalian HMRTN. The physical network model contained 154 nodes and 238 edges, and the statistical analysis results showed that (1 the cumulative node degree of physical network was subjected to exponential distribution, showing the network properties of random network and that (2 the HMRTN had small characteristic path length and large network clustering coefficient, which was a typical small-world network. The service network model contained 569 nodes and 1318 edges, and the statistical analysis results showed that (1 the cumulative node degree of service network was subjected to power-law distribution, showing the network properties of scale-free network and that (2 the relationship between nodes strength and their descending order ordinal and the relationship between nodes strength and cumulative nodes strength were both subjected to power-law distribution, also showing the network properties of scale-free network.

  12. Optimized Field Sampling and Monitoring of Airborne Hazardous Transport Plumes; A Geostatistical Simulation Approach

    Energy Technology Data Exchange (ETDEWEB)

    Chen, DI-WEN

    2001-11-21

    Airborne hazardous plumes inadvertently released during nuclear/chemical/biological incidents are mostly of unknown composition and concentration until measurements are taken of post-accident ground concentrations from plume-ground deposition of constituents. Unfortunately, measurements often are days post-incident and rely on hazardous manned air-vehicle measurements. Before this happens, computational plume migration models are the only source of information on the plume characteristics, constituents, concentrations, directions of travel, ground deposition, etc. A mobile ''lighter than air'' (LTA) system is being developed at Oak Ridge National Laboratory that will be part of the first response in emergency conditions. These interactive and remote unmanned air vehicles will carry light-weight detectors and weather instrumentation to measure the conditions during and after plume release. This requires a cooperative computationally organized, GPS-controlled set of LTA's that self-coordinate around the objectives in an emergency situation in restricted time frames. A critical step before an optimum and cost-effective field sampling and monitoring program proceeds is the collection of data that provides statistically significant information, collected in a reliable and expeditious manner. Efficient aerial arrangements of the detectors taking the data (for active airborne release conditions) are necessary for plume identification, computational 3-dimensional reconstruction, and source distribution functions. This report describes the application of stochastic or geostatistical simulations to delineate the plume for guiding subsequent sampling and monitoring designs. A case study is presented of building digital plume images, based on existing ''hard'' experimental data and ''soft'' preliminary transport modeling results of Prairie Grass Trials Site. Markov Bayes Simulation, a coupled Bayesian

  13. 33 CFR 126.27 - General permit for handling dangerous cargo.

    Science.gov (United States)

    2010-07-01

    ...) in bulk, portable tanks, containers, or packagings, at designated waterfront facilities, conditioned... cargo in limited-quantity packaging. (e) Transport units and portable tanks containing dangerous cargo... in the event of an accident. Cargo not required to be segregated, when in break-bulk form, is...

  14. 46 CFR 308.521 - Application for Open Cargo Policy, Form MA-301.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Application for Open Cargo Policy, Form MA-301. 308.521 Section 308.521 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR... for Open Cargo Policy, Form MA-301. The standard form of application for a War Risk Open Cargo...

  15. 49 CFR 180.413 - Repair, modification, stretching, rebarrelling, or mounting of specification cargo tanks.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Repair, modification, stretching, rebarrelling, or... of Cargo Tanks § 180.413 Repair, modification, stretching, rebarrelling, or mounting of specification cargo tanks. (a) General. Any repair, modification, stretching, rebarrelling, or mounting of a cargo...

  16. 19 CFR 192.14 - Electronic information for outward cargo required in advance of departure.

    Science.gov (United States)

    2010-04-01

    ... vessel cargo is to be laden; (ii) For air cargo, including cargo being transported by Air Express.... The AES Commodity Module already captures the requisite export data, so no new data elements for...-ment (low-risk exporter or other exemption) for any export shipment laden that is not subject to...

  17. Controlling the potential hazards of government-sponsored technology. [such as weather modification and the supersonic transports

    Science.gov (United States)

    Wollan, M. J.

    1975-01-01

    The ability was examined of governmental agencies to adequately assess technological programs or projects to which they are committed. The hazards of government-sponsored activities are discussed; these include weather modification, supersonic transport noise, and the value conflicts involved in the fluoridation controversy. These three case studies indicate that the Federal vested interests in the continuation of its technological programs limit its ability to provide adequate technology assessment.

  18. Comparative International Air Cargo Solutions: The Pathway to a Resilient, Adaptable, Balanced and Sustainable Secure Global Air Cargo Supply Chain

    Science.gov (United States)

    2013-12-01

    systems. Dr. Gerald L. Dillinham, the Director of Physical Infrastructure Issues, GAO noted during his testimony that securing the nation’s aviation...9697. Karp , Aaron. “Air Cargo Flattens Out.” Air Transport World 46, no. 1 (2009): 37–39. 74 Kersey, J. W. “The Economics of Air Cargo (Analysis of...Transportation, U.S. Senate. Aviation Security: Progress since September 11, 2001, and the Challenges Ahead. Statement of Gerald L. Dillingham

  19. 75 FR 63192 - Intent To Request Renewal From OMB of One Current Public Collection of Information: Air Cargo...

    Science.gov (United States)

    2010-10-14

    ... qualified to ship cargo on passenger aircraft, also referred to as ``known shippers.'' This information is primarily collected electronically via the Known Shipper Management System (KSMS). Whenever the information... Collection of Information: Air Cargo Security Requirements AGENCY: Transportation Security Administration...

  20. 49 CFR 1548.9 - Acceptance of cargo.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Acceptance of cargo. 1548.9 Section 1548.9..., DEPARTMENT OF HOMELAND SECURITY CIVIL AVIATION SECURITY INDIRECT AIR CARRIER SECURITY § 1548.9 Acceptance of... program. (b) Refusal to transport. Each indirect air carrier must refuse to offer for transport on...

  1. 75 FR 38168 - Hazardous Materials: International Regulations for the Safe Transport of Radioactive Material (TS...

    Science.gov (United States)

    2010-07-01

    ... the Safe Transport of Radioactive Material (TS-R-1); Draft Revision Available for Comment AGENCY... International Atomic Energy Agency's (IAEA) ``Regulations for the Safe Transport of Radioactive Material'' (TS-R... Radioactive Material (TS-R-1), to promote the safe and secure transportation of radioactive material. The...

  2. Who Will Benefit from the Transit Transport of Cargos in Silk Road Economic Belt?%谁将从丝绸之路经济带货物过境运输中获益

    Institute of Scientific and Technical Information of China (English)

    И.Ю.祖延科; 钟建平

    2015-01-01

    近年来,东亚和东南亚国家以过境运输方式出口到欧洲的商品数量逐年增加,过境哈萨克斯坦至欧洲的运输量已经超过过境俄罗斯东西伯利亚和远东至欧洲的运输量总和.当前中国正大力推进"丝绸之路经济带"倡议,寻求对欧运输路线多样化.从现阶段来看,经由俄罗斯东部地区和哈萨克斯坦的运输走廊暂未直接构成竞争,因为服务的对象不同,而且与海运相比,两条运输走廊的货运量微不足道.由于中国是亚洲至欧洲过境运输的主要发货国,在丝绸之路经济带框架内,中亚国家和中国西部省份将首先从跨大陆过境运输中获益,而俄罗斯东部地区和中国东北部省份将受到忽视.后者的目标应该是实现交通运输系统现代化,打造全新的运输体系,完善现有管理模式.%In recent years, east Asian and southeast Asian countries export more and more cargoes to Europe in the method of transit transport, and the transport quantity passing through Kazakhstan to Europe has surpassed the sum total of that passing through Russia East Siberia and that passing through the Far East to Europe. Currently, China is vigorously carrying forward the proposal of "Silk Road Economic Belt", seeking for the diversification in transport paths to Europe. Seeing from the current stage, the transportation corridors through the east area of Russia and Kazakhstan temporarily do not form competition directly, because the service targets are different and the volumes of cargos transported of the two transportation corridors are insignificant compared to the maritime transportation. As China is the major country of dispatch in the transit transport from Asia to Europe, in the framework of Silk Road Economic Belt, the central Asian countries and western provinces in the west of China will first benefit from the cross-continent transit transport, while the east area of Russia and the Northeast China will both be neglected

  3. 14 CFR 121.287 - Carriage of cargo in cargo compartments.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Carriage of cargo in cargo compartments....287 Carriage of cargo in cargo compartments. When cargo is carried in cargo compartments that are..., the cargo must be loaded so as to allow a crewmember to effectively reach all parts of the...

  4. 14 CFR 125.185 - Carriage of cargo in cargo compartments.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Carriage of cargo in cargo compartments... Requirements § 125.185 Carriage of cargo in cargo compartments. When cargo is carried in cargo compartments... during flight, the cargo must be loaded so as to allow a crewmember to effectively reach all parts of...

  5. Cargo-mix optimization in Liner Shipping

    DEFF Research Database (Denmark)

    Christensen, Jonas Mark; Pacino, Dario; Fonseca, Joao Filipe Paiva

    , it is hard tomotivate companies to pay for cleaner transport since transportation is not visible to end customers,and therefore cannot justify a higher cost. Hence, optimization may be one of the few options forlimiting CO2 emission of international trade. A possible direction is to focus on vessels...... composition available in the different portsmight not be suitable for the full utilization of the vessel. The focus of our work is the analysis ofvessels’ cargo-mix, in particular finding what cargo composition is needed for a vessel to maximizeits utilization on a given service. Such a model can have various...... applications ranging from drivingrate prices, improving fleet composition and network design ((Christiansen et al., 2007; Reinhardtand Pisinger, 2012; Brouer et al., 2014))....

  6. Hazard identification and characterization of welfare aspects during transport of farm animals

    NARCIS (Netherlands)

    Reenen, van C.G.; Reimert, H.G.M.; Gerritzen, M.A.; Leenstra, F.R.; Lambooij, E.

    2008-01-01

    Within the EU, free movement of animals from one Member State to another and more uniformity among production animals and production systems has resulted in more long distance transport from farm to farm or from farm to slaughterhouse. Since there is a lot of discussion about transport of farm anima

  7. 75 FR 63 - Hazardous Materials: Revision to Requirements for the Transportation of Batteries and Battery...

    Science.gov (United States)

    2010-01-04

    ... Batteries and Battery-Powered Devices; and Harmonization With the United Nations Recommendations... safe transportation of batteries and battery-powered devices. This final rule corrects several errors... clarifications addressing the safe transportation of batteries and battery-powered devices. This final rule...

  8. 49 CFR 175.75 - Quantity limitations and cargo location.

    Science.gov (United States)

    2010-10-01

    ... CFR 25.857(b) or for a Class C aircraft cargo compartment in 14 CFR 25.857(c). A package bearing a KEEP AWAY FROM HEAT handling marking must be protected from direct sunshine and stored in a cool and ventilated place, away from sources of heat. (c) For each package containing a hazardous material...

  9. Cooperative transport by small teams of molecular motors

    OpenAIRE

    Klumpp, Stefan; Muller, Melanie J. I.; Lipowsky, Reinhard

    2006-01-01

    Molecular motors power directed transport of cargoes within cells. Even if a single motor is sufficient to transport a cargo, motors often cooperate in small teams. We discuss the cooperative cargo transport by several motors theoretically and explore some of its properties. In particular we emphasize how motor teams can drag cargoes through a viscous environment.

  10. 49 CFR 175.702 - Separation distance requirements for packages containing Class 7 (radioactive) materials in cargo...

    Science.gov (United States)

    2010-10-01

    ... containing Class 7 (radioactive) materials in cargo aircraft. 175.702 Section 175.702 Transportation Other... (radioactive) materials in cargo aircraft. (a) No person may carry in a cargo aircraft any package required by... separation distance between the surfaces of the radioactive materials packages, overpacks or...

  11. 49 CFR 176.84 - Other requirements for stowage and segregation for cargo vessels and passenger vessels.

    Science.gov (United States)

    2010-10-01

    ... May be stowed in portable magazine or metal locker. 16 No other cargo may be stowed in the same hold... solids. 101 Stow “separated from” iron oxide. 102 Stow “separated from” all odor absorbing cargoes. 103... must be steel. 15E On deck, cargo transport unit must be leakproof. 17E On deck stowage is...

  12. 75 FR 27273 - Hazardous Materials; Packages Intended for Transport by Aircraft

    Science.gov (United States)

    2010-05-14

    ... search the electronic form of any written communications and comments received into any of our dockets by... transportation. We note that it is highly unlikely that a carrier or other entity without intimate knowledge of a...

  13. BNFL's experience in preparing and implementing radiation protection programmes for the control of exposure to workers involved with the international transport of nuclear cargoes

    Energy Technology Data Exchange (ETDEWEB)

    Billing, D. [Spent Fuel Services, British Nuclear Fuels plc, Warrington, Cheshire (United Kingdom)

    2004-07-01

    BNFL International Transport have successfully developed appropriate Radiation Protection Programmes for their business. The business supports BNFL's worldwide Nuclear Fuel Services with key customer bases in Europe, Japan and the UK, utilising marine, rail and road modal transports. Experience in the business spans over 4 decades. The preparation of RPP's for each aspect of its operations has been made relatively straight forward in that the key elements within the internationally recognised model RPP (by WNTI) were already in place in BNFL's procedures to satisfy current National UK and International Regulations. Arrangements are supported by Management systems which comply with International Standards for Quality Assurance. Exposure to key worker groups continues to be within Category 1 (less than 1mSv/y) of the IAEA Transport Regulations TS-R-1 (ST-1 revised).

  14. Acoustic Multipurpose Cargo Transfer Bag

    Science.gov (United States)

    Baccus, Shelley

    2015-01-01

    The Logistics Reduction (LR) project within the Advanced Exploration Systems (AES) program is tasked with reducing logistical mass and repurposing logistical items. Multipurpose Cargo Transfer Bags (MCTB) are designed to be the same external volume as a regular cargo transfer bag, the common logistics carrier for the International Space Station. After use as a cargo bag, the MCTB can be unzipped and unfolded to be reused. This Acoustic MCTBs transform into acoustic blankets after the initial logistics carrying objective is complete.

  15. Cargo binding activates myosin VIIA motor function in cells.

    Science.gov (United States)

    Sakai, Tsuyoshi; Umeki, Nobuhisa; Ikebe, Reiko; Ikebe, Mitsuo

    2011-04-26

    Myosin VIIA, thought to be involved in human auditory function, is a gene responsible for human Usher syndrome type 1B, which causes hearing and visual loss. Recent studies have suggested that it can move processively if it forms a dimer. Nevertheless, it exists as a monomer in vitro, unlike the well-known two-headed processive myosin Va. Here we studied the molecular mechanism, which is currently unknown, of activating myosin VIIA as a cargo-transporting motor. Human myosin VIIA was present throughout cytosol, but it moved to the tip of filopodia upon the formation of dimer induced by dimer-inducing reagent. The forced dimer of myosin VIIA translocated its cargo molecule, MyRip, to the tip of filopodia, whereas myosin VIIA without the forced dimer-forming module does not translocate to the filopodial tips. These results suggest that dimer formation of myosin VIIA is important for its cargo-transporting activity. On the other hand, myosin VIIA without the forced dimerization module became translocated to the filopodial tips in the presence of cargo complex, i.e., MyRip/Rab27a, and transported its cargo complex to the tip. Coexpression of MyRip promoted the association of myosin VIIA to vesicles and the dimer formation. These results suggest that association of myosin VIIA monomers with membrane via the MyRip/Rab27a complex facilitates the cargo-transporting activity of myosin VIIA, which is achieved by cluster formation on the membrane, where it possibly forms a dimer. Present findings support that MyRip, a cargo molecule, functions as an activator of myosin VIIA transporter function.

  16. The Scenario of Brazilian Amazon Transportation Infrastructure in the Natural Hazards Context

    Directory of Open Access Journals (Sweden)

    Rafael Almeida Flores

    2015-05-01

    Full Text Available The development of a region is related, in part, to its ability to establish relations with other regions and the efficiency with which it operates internally and streamlines their intra relations. The study of the impacts in the availability of transport infrastructure in regional development interests by the influence it has on the location decisions of investment. The network of transport infrastructure in the Brazilian Amazon region is susceptible to interruptions in its functioning by pressures arising from the interaction of coupled human and natural systems, impacting regional development mainly by isolating regions raising concerns about human security of local residents and the economic development to the extent that regional production does not circulates temporarily, eliminating one of the economy dynamics main stages. The susceptibility indicators of transport infrastructure system in the Amazon are unclear and this study presents disruptions causes, frequency, potential risks and impacts in this system functioning.

  17. 46 CFR 154.315 - Cargo pump and cargo compressor rooms.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Cargo pump and cargo compressor rooms. 154.315 Section... CARGOES SAFETY STANDARDS FOR SELF-PROPELLED VESSELS CARRYING BULK LIQUEFIED GASES Design, Construction and Equipment Ship Arrangements § 154.315 Cargo pump and cargo compressor rooms. (a) Cargo pump rooms and...

  18. 46 CFR 154.1826 - Opening of cargo tanks and cargo sampling.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Opening of cargo tanks and cargo sampling. 154.1826... CARGOES SAFETY STANDARDS FOR SELF-PROPELLED VESSELS CARRYING BULK LIQUEFIED GASES Operations § 154.1826 Opening of cargo tanks and cargo sampling. (a) The master shall ensure that each cargo tank opening...

  19. Chapter C. The Loma Prieta, California, Earthquake of October 17, 1989 - Fire, Police, Transportation and Hazardous Materials

    Science.gov (United States)

    Van Anne, Craig; Scawthorn, Charles R.

    1994-01-01

    The papers in this chapter discuss some of the failures and successes that resulted from the societal response by a multitude of agencies to the Loma Prieta earthquake. Some of the lessons learned were old ones relearned. Other lessons were obvious ones which had gone unnoticed. Still, knowledge gained from past earthquakes spawned planning and mitigation efforts which proved to be successful in limiting the aftermath effects of the Loma Prieta event. At least four major areas of response are presented in this chapter: the Oakland Police Department response to the challenge of controlled access to the Cypress freeway collapse area without inhibiting relief and recovery efforts; search and rescue of the freeway collapse and the monumental crisis management problem that accompanied it; the short- and long-term impact on transbay transportation systems to move a large work force from home to business; and the handling of hazardous material releases throughout the Bay Area.

  20. The ISTIMES project: a new integrated system for monitoring critical transport infrastructures interested by natural hazards

    Science.gov (United States)

    Proto, Monica; Massimo, Bavusi; Francesco, Soldovieri

    2010-05-01

    The research project "Integrated System for Transport Infrastructure surveillance and Monitoring by Electromagnetic Sensing" (ISTIMES), was approved in the 7th Framework Programme, in the Joint Call ICT and Security and started on 1st July 2009. The purpose of ISTIMES project is to design, assess and promote an ICT-based system, exploiting distributed and local sensors, for non-destructive electromagnetic monitoring in order to achieve the critical transport infrastructures more reliable and safe. The transportation sector's components are susceptible to the consequences of natural disasters and can also be attractive as terrorist targets. The sector's size, its physically dispersed and decentralized nature, the many public and private entities involved in its operations, the critical importance of cost considerations, and the inherent requirement of convenient accessibility to its services by all users - make the transportation particularly vulnerable to security and safety threats. As well known, the surface transportation system consists of interconnected infrastructures including highways, transit systems, railroads, airports, waterways, pipelines and ports, and the vehicles, aircraft, and vessels that operate along these networks. Thus, interdependencies exist between transportation and nearly every other sector of the economy and the effective operation of this system is essential to the European economic productivity; therefore, transportation sector protection is of paramount importance since threats to it may impact other industries that rely on it. The system exploits an open network architecture that can accommodate a wide range of sensors, static and mobile, and can be easily scaled up to allow the integration of additional sensors and interfacing with other networks. It relies on heterogeneous state-of-the-art electromagnetic sensors, enabling a self-organizing, self-healing, ad-hoc networking of terrestrial sensors, supported by specific satellite

  1. Natural hazards along the oil and gas transport pipelines in Northwest China

    Science.gov (United States)

    Hong, Xie; Yu, Zhao; Yong, Li

    2017-04-01

    The northwest China, including the provincial districts of Xinjiang, Qinghai, and Gansu, is the key area for transporting oil and gas from the west to the east, through where runs the China-Kazakhstan crude oil pipeline linking the Central Asia resources of oil and gas. The area is 283.6 km2and the pipeline is 15 650 km long, suffering severe disasters destroying the operation of oil and gas transport. Major disasters are torrential floods, debris flows, rockfalls, landslides, wind erosion, and ground subsidence, having the following characteristics: 1) most disasters are distributed along the rivers; 2) special strata are effective in controlling some types of disasters; 3) landslides, collapses and debris flows are especially concentrated in steep landforms; 4) the disasters are highly likely to occur under the extreme climate; 5) the disasters are distributed in parallel to the earthquake zones.

  2. Food animal transport: a potential source of community exposures to health hazards from industrial farming (CAFOs).

    Science.gov (United States)

    Rule, Ana M; Evans, Sean L; Silbergeld, Ellen K

    2008-01-01

    Use of antimicrobial feed additives in food animal production is associated with selection for drug resistance in bacterial pathogens, which can then be released into the environment through occupational exposures, high volume ventilation of animal houses, and land application of animal wastes. We tested the hypothesis that current methods of transporting food animals from farms to slaughterhouses may result in pathogen releases and potential exposures of persons in vehicles traveling on the same road. Air and surface samples were taken from cars driving behind poultry trucks for 17 miles. Air conditioners and fans were turned off and windows fully opened. Background and blank samples were used for quality control. Samples were analyzed for susceptible and drug-resistant strains. Results indicate an increase in the number of total aerobic bacteria including both susceptible and drug-resistant enterococci isolated from air and surface samples, and suggest that food animal transport in open crates introduces a novel route of exposure to harmful microorganisms and may disseminate these pathogens into the general environment. These findings support the need for further exposure characterization, and attention to improving methods of food animal transport, especially in highly trafficked regions of high density farming such as the Delmarva Peninsula.

  3. Using Monte Carlo Simulation To Improve Cargo Mass Estimates For International Space Station Commercial Resupply Flights

    Science.gov (United States)

    2016-12-01

    Contract COTS Commercial Orbital Transportation Services CPAF cost plus award fee CRS Commercial Resupply Service CTB cargo transfer bag CTBE cargo...and perform cargo resupply services for ISS. The transition from traditional government-led, Level-Of-Effort (LOE) and Cost Plus Award Feed (CPAF...lower the cost associated with spaceflight. To achieve that cost savings the CRS providers priced their services based on minimal analyses and

  4. 基于期权理论的铁路货运定价模型%Pricing model of railway cargo transport based on option theory

    Institute of Scientific and Technical Information of China (English)

    冯芬玲; 李菲菲

    2012-01-01

    In the course of rail freight pricing introduces the concept of options was introduced, and using the binary tree price, the model was constructed based on maximun return for the railway transport sector and the customer, thereby the risks of the rail transport sector and clients in the case of market price volatility was avoided. The results show that the optimal pricing decisions of the rail transport and clients can obtain the stock market prices and the quantity of options. The stock market prices is positive to the spot market prices, long -term cost while negative to the short - term cost; as the option prices and the option of executive price increases, the quantity of options of freight agent is reduced.%为了规避铁路运输企业和协议客户在市场价格波动情况下所面临的风险,在铁路货运的定价过程中引入期权的概念,利用二叉树模型为期权定价,在此基础上构建了基于铁路运输企业和协议客户收益最大条件下的铁路货运定价模型.研究结果表明:通过铁路运输企业和协议客户的最优定价决策可以求得铁路运输企业制定的协议价格和协议客户的期权购买量;协议价格与现货市场价格正相关,与铁路运输企业的长期准备成本正相关、短期准备成本负相关;随着期权价格和期权执行价格的升高,协议客户在契约市场所购买的期权数量逐渐减少.

  5. Cargo-cult training

    Science.gov (United States)

    Magueijo, João

    2009-12-01

    Richard Feynman, in one of his famous rants, evoked as a metaphor what he called "cargo-cult science". During the Second World War, the indigenous people of the South Pacific became accustomed to US Air Force planes landing on their islands, invariably bringing a profusion of desirable goods and tasty foods. When the war ended, they were distressed by the discontinuation of this popular service. So, they decided to take action. They cleared elongated patches of land to make them look like runways. They lit wood fires where they had seen electric floodlights guiding in the planes. They built a wooden shack and made a man sit inside with two halves of a coconut on each ear and bamboo bars sticking out like antennas: he was the "air controller". And they waited for the planes to return.

  6. Indirect economic impact of landslide hazards by disruption to national road transportation networks; Scotland, United Kingdom.

    Science.gov (United States)

    Postance, Benjamin; Hillier, John; Dijkstra, Tom; Dixon, Neil

    2016-04-01

    The failure of engineered or natural slopes which support or are adjacent to transportation systems often inflicts costly direct physical damage and indirect system disruption. The consequences and severity of indirect impacts vary according to which links, nodes or network facilities are physically disrupted. Moreover, it is often the case that multiple slope failure disruptions are triggered simultaneously following prolonged or intense precipitation events due to a degree of local homogeneity of slope characteristics and materials. This study investigates the application of national commuter statistics and network agent simulation to evaluate indirect impacts of landslide events disrupting the Scottish trunk road transportation network (UK). Previous studies often employ shortest pathway analysis whereas agent simulation has received relatively little attention. British Geological Survey GeoSure landslide susceptibility data is used to select 35 susceptible trunk road segments by means of neighbouring total area at risk. For each of the candidate 35 segments the network and zonal variation in travel time is calculated for a single day of disruption, economic impact is approximated using established governmental and industry transport planning and appraisal values. The results highlight that a number of trunk road segments incur indirect economic losses in the order of tens of thousands of pounds for each day of closure. Calculated losses at the A83 Rest and Be Thankful are 50% greater than previous estimates at £75 thousand per day of closure. Also highlighted are events in which economic impact is relatively minor, yet concentrating on particular communities that can become substantially isolated as a consequence of a single event. The findings of this study are of interest and support wider investigations exploring cost considerations for decision makers and mitigation strategies, in addition to identifying network topological and demand indicators conducive

  7. Reducing Mission Logistics with Multipurpose Cargo Transfer Bags

    Science.gov (United States)

    Baccus, Shelley; Broyan, James Lee, Jr.; Borrego, Melissa

    2016-01-01

    The Logistics Reduction (LR) project within Advanced Exploration Systems (AES) is tasked with reducing logistical mass and repurposing logistical items. Multipurpose Cargo Transfer Bags (MCTB) have been designed such that they can serve the same purpose as a Cargo Transfer Bag (CTB), the common logistics carrying bag for the International Space Station (ISS). After use as a cargo carrier, a regular CTB becomes trash, whereas the MCTB can be unfolded into a flat panel for reuse. Concepts and potential benefits for various MCTB applications will be discussed including partitions, crew quarters, solar radiation storm shelters, acoustic blankets, and forward osmosis water processing. Acoustic MCTBs are currently in use on ISS to reduce the noise generated by the T2 treadmill, which reaches the hazard limit at high speeds. The development of the AMCTB included identification of keep-out zones, acoustic properties, deployment considerations, and structural testing. Features developed for these considerations are applicable to MCTBs for all crew outfitting applications.

  8. Multipurpose Cargo Transfer Bags fro Reducing Exploration Mission Logistics

    Science.gov (United States)

    Baccus, Shelley; Broyan, James Lee, Jr.; Borrego, Melissa

    2016-01-01

    The Logistics Reduction (LR) project within the Advanced Exploration Systems (AES) division is tasked with reducing logistical mass and repurposing logistical items. Multipurpose Cargo Transfer Bags (MCTB) have been designed such that they can serve the same purpose as a Cargo Transfer Bag (CTB), the common logistics carrying bag for the International Space Station (ISS). After use as a cargo carrier, a regular CTB becomes trash, whereas the MCTB can be unfolded into a flat panel for reuse. Concepts and potential benefits for various MCTB applications will be discussed including partitions, crew quarters, solar radiation storm shelters, acoustic blankets, and forward osmosis water processing. Acoustic MCTBs are currently in use on ISS to reduce the noise generated by the T2 treadmill, which reaches the hazard limit at high speeds. The development of the AMCTB included identification of keep out zones, acoustic properties, deployment considerations, and structural testing. Features developed for these considerations are applicable to MCTBs for all crew outfitting applications.

  9. Financial assistance to states and tribes to support emergency preparedness and response and the safe transportation of hazardous shipments: 1996 Update

    Energy Technology Data Exchange (ETDEWEB)

    Bradbury, J.A.; Leyson, J.; Lester, M.K.

    1996-07-01

    This report revises and updates the 1995 report Financial Assistance to States and Tribes to Support Emergency Preparedness and Response and the Safe Transportation of Hazardous Shipments, PNL-10260 (UC-620). The presentation of data and some of the data reported have been changed; these data supersede those presented in the earlier publication. All data have been updated to fiscal year 1995, with the exception of FEMA data that are updated to fiscal year 1994 only. The report identifies and summarizes existing sources of financial assistance to States and Tribes in preparing and responding to transportation emergencies and ensuring the safe transportation of hazardous shipments through their jurisdictions. It is intended for use as an information resource for the U.S. Department of Energy`s Office of Environmental Management (EM), Office of Transportation, Emergency Management, and Analytical Services (EM-76).

  10. Climate Change driven evolution of hazards to Europe's transport infrastructure throughout the twenty-first century

    Science.gov (United States)

    Matulla, Christoph; Hollósi, Brigitta; Andre, Konrad; Gringinger, Julia; Chimani, Barbara; Namyslo, Joachim; Fuchs, Tobias; Auerbach, Markus; Herrmann, Carina; Sladek, Brigitte; Berghold, Heimo; Gschier, Roland; Eichinger-Vill, Eva

    2017-06-01

    Road authorities, freight, and logistic industries face a multitude of challenges in a world changing at an ever growing pace. While globalization, changes in technology, demography, and traffic, for instance, have received much attention over the bygone decades, climate change has not been treated with equal care until recently. However, since it has been recognized that climate change jeopardizes many business areas in transport, freight, and logistics, research programs investigating future threats have been initiated. One of these programs is the Conference of European Directors of Roads' (CEDR) Transnational Research Programme (TRP), which emerged about a decade ago from a cooperation between European National Road Authorities and the EU. This paper presents findings of a CEDR project called CliPDaR, which has been designed to answer questions from road authorities concerning climate-driven future threats to transport infrastructure. Pertaining results are based on two potential future socio-economic pathways of mankind (one strongly economically oriented "A2" and one more balanced scenario "A1B"), which are used to drive global climate models (GCMs) producing global and continental scale climate change projections. In order to achieve climate change projections, which are valid on regional scales, GCM projections are downscaled by regional climate models. Results shown here originate from research questions raised by European Road Authorities. They refer to future occurrence frequencies of severely cold winter seasons in Fennoscandia, to particularly hot summer seasons in the Iberian Peninsula and to changes in extreme weather phenomena triggering landslides and rutting in Central Europe. Future occurrence frequencies of extreme winter and summer conditions are investigated by empirical orthogonal function analyses of GCM projections driven with by A2 and A1B pathways. The analysis of future weather phenomena triggering landslides and rutting events requires

  11. Heat and hazardous contaminant transports in ventilated high-rise industrial halls

    Institute of Scientific and Technical Information of China (English)

    王沨枫; 刘志强; Christoph van Treeck; 王汉青; 唐文武; 寇广孝

    2015-01-01

    Performances and efficiencies of displacement ventilation (DV) and partial ventilation (PV) for industrial halls of different configurations as well as the heat and mass transports within the industrial halls were numerically investigated. Three levels of Rayleigh number(5.8´1010, 1.0´1012 and 2.1´1012) and two values of source contaminant flux (5 mg/s and 50 mg/s) were considered. The inlet Reynolds numbers were 2´104, 5´104, 1.5´105 and 4.5´105 for DV and 5´105, 1´106, 2´106 and 4´106 for PV, respectively. From the results, it is concluded that the above parameters have very complex impacts on the conjugated heat and mass transports. From points of view of acceptable indoor air quality and ventilation efficiency, PV atRe=1´106with side-located sources and 65% of the supply air extracted through floor level outlets is the best choice whenRa=5.8´1010. However, DVs atRe=5´104andRe=1.5´105 with center-located sources and floor-mounted air suppliers are the best choices forRa=1.0´1012 andRa=2.1´1012, respectively. When source contaminant flux reaches 50 mg/s, local extraction as a supplement of general ventilation is recommended. The results can be a first approximation to 3D numerical investigation and preliminary ventilation system design guidelines for high-rise industrial halls.

  12. 农药包装运输的危险性分类与标签%Hazardous Classification and Label on the Package and Transport of Pesticides

    Institute of Scientific and Technical Information of China (English)

    王琛; 张伟; 郭永华; 赵珊红

    2011-01-01

    The pesticide hazards were reviewed and the hazardous classification and label on the pesticide package and transport in the United Nations Recommendations on the transport of dangerous goods model regulations (TDG) was researched. On these bases, an correct classification idea of pesticide samples was proposed. The hazards of pesticide samples were classified and labeled according to the proposed idea and the TDG criterion ultimately.%综述了农药的危险性,研究了联合国(TDG)中对农药包装运输的危险性分类与标签.在此基础上,提出了对农药样品进行正确分类的思路,最终依据提出的思路和TDG的标准对农药样品进行了鉴定分类和标签.

  13. 46 CFR 151.03-30 - Hazardous material.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Hazardous material. 151.03-30 Section 151.03-30 Shipping... BULK LIQUID HAZARDOUS MATERIAL CARGOES Definitions § 151.03-30 Hazardous material. In this part hazardous material means a liquid material or substance that is— (a) Flammable or combustible; (b...

  14. Extensive cargo identification reveals distinct biological roles of the 12 importin pathways

    Science.gov (United States)

    Kimura, Makoto; Morinaka, Yuriko; Imai, Kenichiro; Kose, Shingo; Horton, Paul; Imamoto, Naoko

    2017-01-01

    Vast numbers of proteins are transported into and out of the nuclei by approximately 20 species of importin-β family nucleocytoplasmic transport receptors. However, the significance of the multiple parallel transport pathways that the receptors constitute is poorly understood because only limited numbers of cargo proteins have been reported. Here, we identified cargo proteins specific to the 12 species of human import receptors with a high-throughput method that employs stable isotope labeling with amino acids in cell culture, an in vitro reconstituted transport system, and quantitative mass spectrometry. The identified cargoes illuminated the manner of cargo allocation to the receptors. The redundancies of the receptors vary widely depending on the cargo protein. Cargoes of the same receptor are functionally related to one another, and the predominant protein groups in the cargo cohorts differ among the receptors. Thus, the receptors are linked to distinct biological processes by the nature of their cargoes. DOI: http://dx.doi.org/10.7554/eLife.21184.001 PMID:28117667

  15. 76 FR 4709 - Extension of Agency Information Collection Activity Under OMB Review: Certified Cargo Screening...

    Science.gov (United States)

    2011-01-26

    ... off- airport and includes facilities upstream in the air cargo supply chain, such as shippers, manufacturers, warehousing entities, distributors, third party logistics companies, and Indirect Air Carriers... supply chain to accept, screen, and transport air cargo. The uninterrupted collection of this...

  16. 46 CFR 308.523 - Application for revision of Open Cargo Policy, Form MA-303.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Application for revision of Open Cargo Policy, Form MA-303. 308.523 Section 308.523 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY... Application for revision of Open Cargo Policy, Form MA-303. An application for the revision of an Open...

  17. 46 CFR 308.548 - Standard form of underwriting agency agreement for cargo, Form MA-318.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Standard form of underwriting agency agreement for cargo, Form MA-318. 308.548 Section 308.548 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION... underwriting agency agreement for cargo, Form MA-318. This form, which may be obtained from the American...

  18. 46 CFR 308.545 - Facultative cargo policy, Form MA-316.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Facultative cargo policy, Form MA-316. 308.545 Section 308.545 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK... policy, Form MA-316. The standard form of War Risk Facultative Cargo Policy, Form MA-316, may be...

  19. 46 CFR 308.524 - Application for cancellation of Open Cargo Policy, Form MA-304.

    Science.gov (United States)

    2010-10-01

    ... MA-304. 308.524 Section 308.524 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION... § 308.524 Application for cancellation of Open Cargo Policy, Form MA-304. The standard form of application for cancellation of an Open Cargo Policy Form MA-304 may be obtained from the American War...

  20. GeoClaw-STRICHE: A coupled model for Sediment TRansport In Coastal Hazard Events

    CERN Document Server

    Tang, Hui

    2016-01-01

    GeoClaw-STRICHE is designed for simulating the physical impacts of tsunami as it relates to erosion, transport and deposition. GeoClaw-STRICHE comprises of three components: (1) nonlinear shallow water equations; (2) advection-diffusion equation; (3) an equation for morphology updating. Multiple grain sizes and sediment layers are added into GeoClaw-STRICHE to simulate grain-size distribution and add the capability to develop grain-size trends from bottom to the top of a simulated deposit as well as along the inundation. Unlike previous models based on empirical equations or sediment concentration gradient, the standard Van Leer method is applied to calculate sediment flux. We tested and verified GeoClaw-STRICHE with flume experiment by \\citet{johnson2016experimental} and data from the 2004 Indian Ocean tsunami in Kuala Meurisi as published in \\citet{JGRF:JGRF786}. The comparison with experimental data shows GeoClaw-STRICHE's capability to simulate sediment thickness and grain-size distribution in experimenta...

  1. 46 CFR 64.97 - Cargo hose.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 2 2010-10-01 2010-10-01 false Cargo hose. 64.97 Section 64.97 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING MARINE PORTABLE TANKS AND CARGO HANDLING SYSTEMS Cargo Handling System § 64.97 Cargo hose. Each hose assembly, consisting of couplings and a...

  2. 46 CFR 153.930 - Cargo antidotes.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Cargo antidotes. 153.930 Section 153.930 Shipping COAST... Cargo antidotes. No person may operate a tankship that carries a cargo listed in Table 1 unless the tankship has on board the antidotes described for the cargo in the Medical First Aid Guide for Use...

  3. Proteomics Characterization of Exosome Cargo

    OpenAIRE

    Schey, Kevin L.; Luther, J. Matthew; Rose, Kristie L

    2015-01-01

    Characterization of exosomal cargo is of significant interest because this cargo can provide clues to exosome biogenesis, targeting, and cellular effects and may be a source of biomarkers for disease diagnosis, prognosis and response to treatment. With recent improvements in proteomics technologies, both qualitative and quantitative characterization of exosomal proteins is possible. Here we provide a brief review of exosome proteomics studies and provide detailed protocols for global qualitat...

  4. RUPOK - a web-map application for assessment of impacts of natural hazards on the transportation infrastructure

    Science.gov (United States)

    Bíl, Michal; Kubeček, Jan; Andrášik, Richard; Bílová, Martina; Sedoník, Jiří

    2016-04-01

    We present a web-map application (www.rupok.cz) designed for visualization of losses caused by natural hazards to the transportation infrastructure. This application is an output of a project in which we analyzed direct, indirect and network-wide impacts of major natural disasters which hit the CZ as of 1997. When natural disasters hit a road network the results are often a number of closed road sections. Certain roads may be, however, destroyed, whereas the majority of them are usually only closed and can be reopened after a short period of time. While the computation of direct losses (the cost of remedial works) is fairly simple, the evaluation of indirect and network-wide costs is much more difficult. We created a database of interrupted road and highway sections due to natural processes which includes data since 1997 and which is automatically updated. 6,828 records concerning interrupted communications located on 2,879 road sections are included in the database for the 1997 - 2014 time period. Flooding caused 37 % of the traffic interruptions, followed by fallen trees (22 %), landsliding (5 %) and rockfalls (2 %). The RUPOK webpage contains information on the probabilities of transportation section interruptions due to natural processes as well as the impacts of possible interruptions. The direct losses are depicted as monetary values per road section unit. The values are calculated on the basis of official tables including the prices for construction works. The indirect losses were calculated on the basis of the best alternative route expenses and as traffic intensities affected by a road section interruption.

  5. Bicaudal-D: Switching motors, cargo and direction

    NARCIS (Netherlands)

    G.D. Splinter (Daniël)

    2008-01-01

    textabstractScope of this thesis Transport of vesicles and organelles is an essential cellular process. Proteins like Rab GTPases, specialized adaptor proteins and motor proteins are involved in targeting and movement of cargos to their destination. This thesis describes the function of the mammalia

  6. 76 FR 60755 - Air Cargo Screening; Reopening of Comment Period

    Science.gov (United States)

    2011-09-30

    ...-6, 1549-1] RIN 1652-AA64 Air Cargo Screening; Reopening of Comment Period AGENCY: Transportation Security Administration, DHS. ACTION: Final rule; reopening of comment period. SUMMARY: On August 18, 2011... security threat assessments, and provided a 30-day public comment period that ended on September 19, 2011...

  7. CH-47F Improved Cargo Helicopter (CH-47F)

    Science.gov (United States)

    2015-12-01

    supply chain and industrial base. Nuclear Costs None CH-47F December 2015 SAR March 21, 2016 18:18:21 UNCLASSIFIED 22 Unit Cost Unit Cost Report...mission is transportation of ground forces, Class III/Class V supplies , and other battle critical cargo in support of all future contingencies. The CH

  8. Spatial partitioning of secretory cargo from Golgi resident proteins in live cells

    Directory of Open Access Journals (Sweden)

    White Jamie

    2001-10-01

    Full Text Available Abstract Background To maintain organelle integrity, resident proteins must segregate from itinerant cargo during secretory transport. However, Golgi resident enzymes must have intimate access to secretory cargo in order to carry out glycosylation reactions. The amount of cargo and associated membrane may be significant compared to the amount of Golgi membrane and resident protein, but upon Golgi exit, cargo and resident are efficiently sorted. How this occurs in live cells is not known. Results We observed partitioning of the fluorescent Golgi resident T2-CFP and fluorescent cargo proteins VSVG3-YFP or VSVG3-SP-YFP upon Golgi exit after a synchronous pulse of cargo was released from the ER. Golgi elements remained stable in overall size, shape and relative position as cargo emptied. Cargo segregated from resident rapidly by blebbing into micron-sized domains that contained little or no detectable resident protein and that appeared to be continuous with the parent Golgi element. Post-Golgi transport carriers (TCs exited repeatedly from these domains. Alternatively, entire cargo domains exited Golgi elements, forming large TCs that fused directly with the plasma membrane. However, domain formation did not appear to be an absolute prerequisite for TC exit, since TCs also exited directly from Golgi elements in the absence of large domains. Quantitative cargo-specific photobleaching experiments revealed transfer of cargo between Golgi regions, but no discrete intra-Golgi TCs were observed. Conclusions Our results establish domain formation via rapid lateral partitioning as a general cellular strategy for segregating different transmembrane proteins along the secretory pathway and provide a framework for consideration of molecular mechanisms of secretory transport.

  9. Analysis of Humanitarian Assistance Cargo Transportation

    Science.gov (United States)

    2012-06-01

    are located in Pearl Harbor, Hawaii; Norfolk, Virginia; Mayport, Florida; Singapore; and Yokosuka, Japan. At its core, PH is a Navy program, funded...Thomas, A., & Kopczak, L. (2005). From logistics to supply chain management: The path forward in the humanitarian sector. Fritz Institute, 15, 1

  10. Defense Transportation Regulation Part 2, Cargo Movement.

    Science.gov (United States)

    1998-08-01

    challenge the movement request in accordance with Service challenge criteria. If challenged , the requisitioner must then justify the airlift requirement...complete rounds for Category I fire configuration (e.g., Hamlet, Redeye, Stinger, missiles and rockets. Dragon, LAW, Viper ). Also where launcher tube...WA 5 Libya LY EA 1 Liechtenstein LS EA 1 Luxembourg LU EA 1 Macao MC WA 5 Malaysia MY WA 5 Maldives MV WA 5 Malta MT EA 1 Martinique MB EA 1 Mauritius

  11. Fate and transport processes controlling the migration of hazardous and radioactive materials from the Area 5 Radioactive Waste Management Site (RWMS)

    Energy Technology Data Exchange (ETDEWEB)

    Estrella, R.

    1994-10-01

    Desert vadose zones have been considered as suitable environments for the safe and long-term isolation of hazardous wastes. Low precipitation, high evapotranspiration and thick unsaturated alluvial deposits commonly found in deserts make them attractive as waste disposal sites. The fate and transport of any contaminant in the subsurface is ultimately determined by the operating retention and transformation processes in the system and the end result of the interactions among them. Retention (sorption) and transformation are the two major processes that affect the amount of a contaminant present and available for transport. Retention processes do not affect the total amount of a contaminant in the soil system, but rather decrease or eliminate the amount available for transport at a given point in time. Sorption reactions retard the contaminant migration. Permanent binding of solute by the sorbent is also possible. These processes and their interactions are controlled by the nature of the hazardous waste, the properties of the porous media and the geochemical and environmental conditions (temperature, moisture and vegetation). The present study summarizes the available data and investigates the fate and transport processes that govern the migration of contaminants from the Radioactive Waste Management Site (RWMS) in Area 5 of the Nevada Test Site (NTS). While the site is currently used only for low-level radioactive waste disposal, past practices have included burial of material now considered hazardous. Fundamentals of chemical and biological transformation processes are discussed subsequently, followed by a discussion of relevant results.

  12. 77 FR 24506 - Extension of Agency Information Collection Activity Under OMB Review: Air Cargo Security...

    Science.gov (United States)

    2012-04-24

    ... IACs have qualified to ship cargo on passenger aircraft. This information is primarily collected electronically via the Known Shipper Management System (KSMS). Whenever the information cannot be entered into... SECURITY [Transportation Security Administration Extension of Agency Information Collection Activity Under...

  13. Report on the 2011 and 2012 NASA Ames Research Center (ARC) / Alaska State Cargo Airship Workshops

    Science.gov (United States)

    Hochstettler, Ronald

    2012-01-01

    This presentation will summarize the Cargo Airships for Northern Operations workshop that was held August 24-25, 2011. This workshop co-sponsored by NASA ARC and the Alaska State Department of Transportation was initiated by interest from Alaska Lt. Governor Mead Treadwell for assistance in investigating the potential benefits of proposed cargo airships for the Alaskan economy and societal needs. The workshop provided a brief background on the technology and operational aspects of conventional airships and hybrids followed by presentations on issues affecting cargo airship operations such as weather management, insurance, regulations, crew duty/rest rules, and available support infrastructures. Speakers representing potential cargo airship users from Alaskan State and commercial organizations presented the needs they felt could be met by cargo airship services. Presenters from Canadian private and military interests also detailed applications and missions that cargo airships could provide to remote regions of Canada. Cost drivers of cargo airship operations were also addressed and tools for modeling and analyzing operational factors and costs affecting cargo airship operations were discussed. Four breakout sessions were held which allowed workshop participants to contribute inputs to four topic areas: Business Approaches and Strategies (financing incentives public/private partnerships etc) for Airship Development and Operation, Design, Development, Production Challenges, and Possible Solutions, Regulatory, Certification, Legal, and Insurance Issues, and Operational Issues, Customer Requirements, and Airship Requirements. A follow on to the 2011 cargo airship workshop is being planned for July 31 August 2, 2012. A status update on this second workshop will also be presented.

  14. A systematic approach to pair secretory cargo receptors with their cargo suggests a mechanism for cargo selection by Erv14.

    Science.gov (United States)

    Herzig, Yonatan; Sharpe, Hayley J; Elbaz, Yael; Munro, Sean; Schuldiner, Maya

    2012-01-01

    The endoplasmic reticulum (ER) is the site of synthesis of secreted and membrane proteins. To exit the ER, proteins are packaged into COPII vesicles through direct interaction with the COPII coat or aided by specific cargo receptors. Despite the fundamental role of such cargo receptors in protein traffic, only a few have been identified; their cargo spectrum is unknown and the signals they recognize remain poorly understood. We present here an approach we term "PAIRS" (pairing analysis of cargo receptors), which combines systematic genetic manipulations of yeast with automated microscopy screening, to map the spectrum of cargo for a known receptor or to uncover a novel receptor for a particular cargo. Using PAIRS we followed the fate of ∼150 cargos on the background of mutations in nine putative cargo receptors and identified novel cargo for most of these receptors. Deletion of the Erv14 cargo receptor affected the widest range of cargo. Erv14 substrates have a wide array of functions and structures; however, they are all membrane-spanning proteins of the late secretory pathway or plasma membrane. Proteins residing in these organelles have longer transmembrane domains (TMDs). Detailed examination of one cargo supported the hypothesis that Erv14 dependency reflects the length rather than the sequence of the TMD. The PAIRS approach allowed us to uncover new cargo for known cargo receptors and to obtain an unbiased look at specificity in cargo selection. Obtaining the spectrum of cargo for a cargo receptor allows a novel perspective on its mode of action. The rules that appear to guide Erv14 substrate recognition suggest that sorting of membrane proteins at multiple points in the secretory pathway could depend on the physical properties of TMDs. Such a mechanism would allow diverse proteins to utilize a few receptors without the constraints of evolving location-specific sorting motifs.

  15. 危险品运输方式优化研究%Research on optimization for transportation way of hazardous materials

    Institute of Scientific and Technical Information of China (English)

    郭丰润; 韩文涛; 魏毓

    2013-01-01

    In the given hazardous materials transportation network, many ways may be available to transport the hazardous materials, However, different ways may lead to the difference in the cost of transportation and loss of total social expectations. The selection method of best mode andtransport path to move the goods of danger in a given condition was studied. Through a simulation example, the solving method of the model was presented. The comparison of the different transportation modes showed that a combination of different ways can lower the cost of the transportation as well as the loss of the total social expectations.%在危险品运输过程中,可能存在多种运输方式,采用不同的运输方式运输单位危险品的成本以及社会总期望损失不同.研究了在给定条件下,最佳运输方式和运输路径的选择方法.通过一个仿真例子说明了该模型的求解方法,通过对不同运输方式的对比发现,在一定情况下,采用多种方式交叉组合的运输方式可以降低单位危险品的运输成本以及社会总期望损失.

  16. Strong Interest In China’s Cargo Market——An interview with Jean-Peter Jansen, chairman of the Executive Board of Lufthansa Cargo AG.

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    <正>Lufthansa Cargo AG ranks top among European airlines in the flights bound for China. It has 14 weekly flights for Hong Kong to transport 720 tons of cargo and mails, nine weekly services for Shanghai to carry 450 tons and four weekly flights for Beijing to handle 250 tons.The carrier is showing strong interest in the Chinese market, for 11 per cent of its sales in 2003, 2.16 billion euro came from China.

  17. Opportunity of Constructing a Cargo Terminal – Case Study Brașov International Airport, Romania

    Directory of Open Access Journals (Sweden)

    Gabriel BRĂTUCU

    2017-02-01

    Full Text Available Air transport and especially air cargo transport became ever more important during the last 25 years, with a signifi cant impact upon economic development. Air cargo transport supports regional economic development, provided there is suffi cient local demand for its services. In our study, we have identifi ed signifi cant elements of the impact a cargo terminal at the International Brașov-Ghimbav Airport would have upon local economic development. For this purpose, we have conducted a quantitative market research. We have reached the conclusion that constructing a cargo terminal at the Brașov-Ghimbav Airport is a necessary investment in the current economic context, with an important contribution to the economic development of its surrounding counties. The positive results registered in our study could contribute to improving the economic and fi nancial prospects of Brașov-Ghimbav Airport and attract investors in this project.

  18. Mars Hybrid Propulsion System Trajectory Analysis. Part II; Cargo Missions

    Science.gov (United States)

    Chai, Patrick R.; Merrill, Raymond G.; Qu, Min

    2015-01-01

    NASA's Human Spaceflight Architecture Team is developing a reusable hybrid transportation architecture in which both chemical and electric propulsion systems are used to send crew and cargo to Mars destinations such as Phobos, Deimos, the surface of Mars, and other orbits around Mars. By combining chemical and electrical propulsion into a single spaceship and applying each where it is more effective, the hybrid architecture enables a series of Mars trajectories that are more fuel-efficient than an all chemical architecture without significant increases in flight times. This paper shows the feasibility of the hybrid transportation architecture to pre-deploy cargo to Mars and Phobos in support of the Evolvable Mars Campaign crew missions. The analysis shows that the hybrid propulsion stage is able to deliver all of the current manifested payload to Phobos and Mars through the first three crew missions. The conjunction class trajectory also allows the hybrid propulsion stage to return to Earth in a timely fashion so it can be reused for additional cargo deployment. The 1,100 days total trip time allows the hybrid propulsion stage to deliver cargo to Mars every other Earth-Mars transit opportunity. For the first two Mars surface mission in the Evolvable Mars Campaign, the short trip time allows the hybrid propulsion stage to be reused for three round-trip journeys to Mars, which matches the hybrid propulsion stage's designed lifetime for three round-trip crew missions to the Martian sphere of influence.

  19. 46 CFR 153.907 - Cargo information.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Cargo information. 153.907 Section 153.907 Shipping... Information § 153.907 Cargo information. (a) The master shall ensure that the following information for each... process for the vessel. (b) The master shall make sure that the following information for cargoes...

  20. 46 CFR 154.1858 - Cargo hose.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Cargo hose. 154.1858 Section 154.1858 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES SAFETY STANDARDS FOR SELF-PROPELLED VESSELS CARRYING BULK LIQUEFIED GASES Operations § 154.1858 Cargo hose. The person...

  1. 46 CFR 45.137 - Cargo ports.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 2 2010-10-01 2010-10-01 false Cargo ports. 45.137 Section 45.137 Shipping COAST GUARD....137 Cargo ports. (a) Unless otherwise authorized by the Commandant, the lower edge of any opening for cargo, personnel, machinery access, or similar opening in the side of a ship must be above a line...

  2. 29 CFR 1917.114 - Cargo doors.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 7 2010-07-01 2010-07-01 false Cargo doors. 1917.114 Section 1917.114 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) MARINE TERMINALS Terminal Facilities § 1917.114 Cargo doors. (a) Mechanically operated. (1) Cargo...

  3. 46 CFR 28.885 - Cargo gear.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Cargo gear. 28.885 Section 28.885 Shipping COAST GUARD... Aleutian Trade Act Vessels § 28.885 Cargo gear. (a) The safe working load (SWL) for the assembled gear shall be marked on the heel of each cargo boom, crane, or derrick. These letters and figures are to...

  4. Cargo-shell and cargo-cargo couplings govern the mechanics of artificially loaded virus-derived cages

    Science.gov (United States)

    Llauró, Aida; Luque, Daniel; Edwards, Ethan; Trus, Benes L.; Avera, John; Reguera, David; Douglas, Trevor; Pablo, Pedro J. De; Castón, José R.

    2016-04-01

    Nucleic acids are the natural cargo of viruses and key determinants that affect viral shell stability. In some cases the genome structurally reinforces the shell, whereas in others genome packaging causes internal pressure that can induce destabilization. Although it is possible to pack heterologous cargoes inside virus-derived shells, little is known about the physical determinants of these artificial nanocontainers' stability. Atomic force and three-dimensional cryo-electron microscopy provided mechanical and structural information about the physical mechanisms of viral cage stabilization beyond the mere presence/absence of cargos. We analyzed the effects of cargo-shell and cargo-cargo interactions on shell stability after encapsulating two types of proteinaceous payloads. While bound cargo to the inner capsid surface mechanically reinforced the capsid in a structural manner, unbound cargo diffusing freely within the shell cavity pressurized the cages up to ~30 atm due to steric effects. Strong cargo-cargo coupling reduces the resilience of these nanocompartments in ~20% when bound to the shell. Understanding the stability of artificially loaded nanocages will help to design more robust and durable molecular nanocontainers.Nucleic acids are the natural cargo of viruses and key determinants that affect viral shell stability. In some cases the genome structurally reinforces the shell, whereas in others genome packaging causes internal pressure that can induce destabilization. Although it is possible to pack heterologous cargoes inside virus-derived shells, little is known about the physical determinants of these artificial nanocontainers' stability. Atomic force and three-dimensional cryo-electron microscopy provided mechanical and structural information about the physical mechanisms of viral cage stabilization beyond the mere presence/absence of cargos. We analyzed the effects of cargo-shell and cargo-cargo interactions on shell stability after encapsulating two

  5. 49 CFR 1544.202 - Persons and property onboard an all-cargo aircraft.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Persons and property onboard an all-cargo aircraft. 1544.202 Section 1544.202 Transportation Other Regulations Relating to Transportation (Continued... SECURITY: AIR CARRIERS AND COMMERCIAL OPERATORS Operations § 1544.202 Persons and property onboard an...

  6. Port Security: Container Cargo Control

    Directory of Open Access Journals (Sweden)

    Vladivoj Vlaković

    2006-05-01

    Full Text Available illicittrafficking of threat materials, especially explosives, chemicalsubstances and radioactive or nuclear material. The transportof the threat materials by using sea routes is an advantageto te"orists especially because of the possible use of ship containers.The container is the basis of world trade. It is assumed thatthe world total movement in containers is about 200 millionTEUs ("20-foot equivalent units" per year. The list of materialstransported by containers which should be subject to inspectionwith the aim of reducing the acts of te"orism includes explosives,narcotics, chemical weapons, hazardous chemicalsand radioactive materials.Of special interest is nuclear te"orism. The risk of nuclearte"orism carried out by sub-national groups should be considerednot only in the construction and/or use of nuclear device,but also in possible radioactive contamination of large urbanareas.The system of ship containers control is an essential componentof «smart border» concept. Modem personnel, parcel,vehicle and cargo inspection systems are non-invasive imagingtechniques based on the use of nuclear analytical techniques.The inspection systems use penetrating radiations: hard x-rays(300 keV or more or gamma-rays from radioactive sources(137Cs and 60Co with energies from 600 to 1300 keV that producea high resolution radiograph of the load. Unfortunately,this information is "non-specific" in that it gives no informationon the nature of objects that do not match_ the travel documentsand are not recognized by a visual analysis of the radiographicpicture. Moreover, there are regions of the containerwherex and gamma-ray systems are "blind" due to the high averageatomic number of the objects i"adiated that appear asblack spots in the radiographic image.The systems being developed are based on the use of fast, 14Me V, neutrons with detection of associated a-particle from nuclearreactionbywhichneutrons are produced (d+t>a+n.Jnsuch a way the possibility to

  7. 46 CFR 153.970 - Cargo transfer piping.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Cargo transfer piping. 153.970 Section 153.970 Shipping... § 153.970 Cargo transfer piping. The person in charge of cargo transfer shall ensure that: (a) Cargo is transferred to or from a cargo tank only through the tankship's cargo piping system; (b) Vapor not returned...

  8. Improving the design of higher-capacity railway tank cars for hazardous materials transport: optimizing the trade-off between weight and safety.

    Science.gov (United States)

    Barkan, Christopher P L

    2008-12-15

    As with many aspects of modern industrial society, decision-makers face trade-offs in considering hazardous materials transportation equipment and practices. Tank cars used for transport of hazardous materials can be made more resistant to damage in accidents through use of a thicker steel tank and other protective features. However, the additional weight of these features reduces the car's capacity and thus its efficiency as a transportation vehicle. In this paper the problem of tank car safety versus weight is developed as a multi-attribute decision problem. North American railroads recently developed specifications for higher capacity tank cars for transportation of hazardous materials including enhanced safety design features. A group of tank car safety design features or "risk reduction options" (RROs) were analyzed with regard to their effect on the conditional probability of release in an accident, and their incremental effect on tank car weight. All possible combinations of these RROs were then analyzed in terms of the reduced release probability per unit of weight increase and the Pareto optimal set of options identified. This set included the combinations of RROs that provided the greatest improvement in safety with the least amount of additional weight for any desired level of tank car weight increase. The analysis was conducted for both non-insulated and insulated tank cars and used two objective functions, minimization of conditional probability of release, and minimization of expected quantity lost, given that a car was derailed in an accident. Sensitivity analyses of the effect of tank car size and use of different objective functions were conducted and the optimality results were found to be robust. The results of this analysis were used by the Association of American Railroads Tank Car Committee to develop new specifications for higher capacity non-insulated and insulated, non-pressure tank cars resulting in an estimated 32% and 24% respective

  9. Overview of Crane Control Systems and the Related Problems: Analysis of Container Oscillation Using Different Types of Cargoes

    Directory of Open Access Journals (Sweden)

    Tomas Eglynas

    2016-04-01

    Full Text Available Growing international trading increased cargo transportation in containers, therefore the port cranes have higher loads. Increased cargo flows can influence transportation safety. It is therefore necessary to review the crane systems and determine what factors might influence the volatility of the container and its cargo during transportation. The paper includes consideration and analysis of crane control systems and related problems. The authors consider the reasons of problems, probable damage and solution methods. The paper also provides the analysis of the relationship between different container cargoes and container oscillations occurring during handling operations using a container crane prototype. The analysis of the effect of different cargoes in containers on loading process and the results of occurring oscillations are presented.

  10. 46 CFR 153.957 - Persons in charge of transferring liquid cargo in bulk or cleaning cargo tanks.

    Science.gov (United States)

    2010-10-01

    ... safely transfer liquid cargo in bulk or to safely clean cargo tanks; (2) Each transfer of liquid cargo in... or cleaning cargo tanks. 153.957 Section 153.957 Shipping COAST GUARD, DEPARTMENT OF HOMELAND... transferring liquid cargo in bulk or cleaning cargo tanks. (a) The owner and operator of the vessel, and his...

  11. 49 CFR 178.275 - Specification for UN Portable Tanks intended for the transportation of liquid and solid hazardous...

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Specification for UN Portable Tanks intended for... Portable Tanks § 178.275 Specification for UN Portable Tanks intended for the transportation of liquid and... definitions and requirements that apply to UN portable tanks intended for the transportation of liquid...

  12. 78 FR 24288 - Application of National Air Cargo Group Inc d/b/a National Airlines for Foreign Scheduled Authority

    Science.gov (United States)

    2013-04-24

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION Office of the Secretary Application of National Air Cargo Group Inc d/b/a National Airlines for Foreign... National Air Cargo Group, Inc., d/b/a National Airlines fit, willing, and able to provide foreign scheduled...

  13. Proteomics characterization of exosome cargo.

    Science.gov (United States)

    Schey, Kevin L; Luther, J Matthew; Rose, Kristie L

    2015-10-01

    Characterization of exosomal cargo is of significant interest because this cargo can provide clues to exosome biogenesis, targeting, and cellular effects and may be a source of biomarkers for disease diagnosis, prognosis and response to treatment. With recent improvements in proteomics technologies, both qualitative and quantitative characterization of exosomal proteins is possible. Here we provide a brief review of exosome proteomics studies and provide detailed protocols for global qualitative, global quantitative, and targeted quantitative analysis of exosomal proteins. In addition, we provide an example application of a standard global quantitative analysis followed by validation via a targeted quantitative analysis of urine exosome samples from human patients. Advantages and limitations of each method are discussed as well as future directions for exosome proteomics analysis.

  14. Commercial Firm Training Practices versus Aerial Port Hazardous Cargo Frustration

    Science.gov (United States)

    2007-03-01

    pertinent information can be gained from a situation ( Leedy and Ormrod , 2005). The distinction between using qualitative methods as a means to...naturals settings” and they “study those phenomena in all their complexity.” ( Leedy and Ormrod , 2005) Qualitative research can be further drilled...echoed by Leedy and Ormrod (2005), who suggest that only internal and external validity should be considered when conducting qualitative research. They

  15. Cargo-shell and cargo-cargo couplings govern the mechanics of artificially loaded virus-derived cages.

    Science.gov (United States)

    Llauró, Aida; Luque, Daniel; Edwards, Ethan; Trus, Benes L; Avera, John; Reguera, David; Douglas, Trevor; Pablo, Pedro J de; Castón, José R

    2016-04-28

    Nucleic acids are the natural cargo of viruses and key determinants that affect viral shell stability. In some cases the genome structurally reinforces the shell, whereas in others genome packaging causes internal pressure that can induce destabilization. Although it is possible to pack heterologous cargoes inside virus-derived shells, little is known about the physical determinants of these artificial nanocontainers' stability. Atomic force and three-dimensional cryo-electron microscopy provided mechanical and structural information about the physical mechanisms of viral cage stabilization beyond the mere presence/absence of cargos. We analyzed the effects of cargo-shell and cargo-cargo interactions on shell stability after encapsulating two types of proteinaceous payloads. While bound cargo to the inner capsid surface mechanically reinforced the capsid in a structural manner, unbound cargo diffusing freely within the shell cavity pressurized the cages up to ∼30 atm due to steric effects. Strong cargo-cargo coupling reduces the resilience of these nanocompartments in ∼20% when bound to the shell. Understanding the stability of artificially loaded nanocages will help to design more robust and durable molecular nanocontainers.

  16. Competitiveness of Slovenian Cargo Shipping

    Directory of Open Access Journals (Sweden)

    Milojka Počuča

    2012-10-01

    Full Text Available The paper presents Slovenian cargo shipping, its system oforganisation, ownership, age and value stntcture. It shows theimportance of shipping in the Slovenian overseas trade and itsimpact on the state's balance of payments. The analysis of thecompetitiveness of shipping was made from the viewpoint ofoperation costs and in comparison with the competitiveness ofEU shippers. The paper concludes with a proposal of possiblesystemic solutions which improve the competitiveness of Slovenianshipping.

  17. Molecular motors pulling cargos in the viscoelastic cytosol: how power strokes beat subdiffusion.

    Science.gov (United States)

    Goychuk, Igor; Kharchenko, Vasyl O; Metzler, Ralf

    2014-08-21

    The discovery of anomalous diffusion of larger biopolymers and submicron tracers such as endogenous granules, organelles, or virus capsids in living cells, attributed to the viscoelastic nature of the cytoplasm, provokes the question whether this complex environment equally impacts the active intracellular transport of submicron cargos by molecular motors such as kinesins: does the passive anomalous diffusion of free cargo always imply its anomalously slow active transport by motors, the mean transport distance along microtubule growing sublinearly rather than linearly in time? Here we analyze this question within the widely used two-state Brownian ratchet model of kinesin motors based on the continuous-state diffusion along microtubules driven by a flashing binding potential, where the cargo particle is elastically attached to the motor. Depending on the cargo size, the loading force, the amplitude of the binding potential, the turnover frequency of the molecular motor enzyme, and the linker stiffness we demonstrate that the motor transport may turn out either normal or anomalous, as indeed measured experimentally. We show how a highly efficient normal active transport mediated by motors may emerge despite the passive anomalous diffusion of the cargo, and study the intricate effects of the elastic linker. Under different, well specified conditions the microtubule-based motor transport becomes anomalously slow and thus significantly less efficient.

  18. Transportability

    Science.gov (United States)

    2013-04-25

    friction ) draft gear and remaining buffer cars (if any) equipped with either standard draft gear or cushioned draft gear, with the draft gear...to flight testing. (b) Once rigged, attach the sling set apex to the cargo hook of a mobile or overhead crane and hoist the item from the ground

  19. The internet of things in transport management in South Africa

    CSIR Research Space (South Africa)

    Dlodlo, N

    2015-05-01

    Full Text Available safety management, aviation management, road traffic management, maritime services management, cargo transport management, cross-border transport management and passenger rail management....

  20. 49 CFR 172.331 - Bulk packagings other than portable tanks, cargo tanks, tank cars and multi-unit tank car tanks.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Bulk packagings other than portable tanks, cargo tanks, tank cars and multi-unit tank car tanks. 172.331 Section 172.331 Transportation Other Regulations... packagings other than portable tanks, cargo tanks, tank cars and multi-unit tank car tanks. (a) Each...

  1. 49 CFR 174.63 - Portable tanks, IM portable tanks, IBCs, Large Packagings, cargo tanks, and multi-unit tank car...

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Portable tanks, IM portable tanks, IBCs, Large Packagings, cargo tanks, and multi-unit tank car tanks. 174.63 Section 174.63 Transportation Other....63 Portable tanks, IM portable tanks, IBCs, Large Packagings, cargo tanks, and multi-unit tank...

  2. Compressed Sensing Techniques Applied to Ultrasonic Imaging of Cargo Containers

    Science.gov (United States)

    Álvarez López, Yuri; Martínez Lorenzo, José Ángel

    2017-01-01

    One of the key issues in the fight against the smuggling of goods has been the development of scanners for cargo inspection. X-ray-based radiographic system scanners are the most developed sensing modality. However, they are costly and use bulky sources that emit hazardous, ionizing radiation. Aiming to improve the probability of threat detection, an ultrasonic-based technique, capable of detecting the footprint of metallic containers or compartments concealed within the metallic structure of the inspected cargo, has been proposed. The system consists of an array of acoustic transceivers that is attached to the metallic structure-under-inspection, creating a guided acoustic Lamb wave. Reflections due to discontinuities are detected in the images, provided by an imaging algorithm. Taking into consideration that the majority of those images are sparse, this contribution analyzes the application of Compressed Sensing (CS) techniques in order to reduce the amount of measurements needed, thus achieving faster scanning, without compromising the detection capabilities of the system. A parametric study of the image quality, as a function of the samples needed in spatial and frequency domains, is presented, as well as the dependence on the sampling pattern. For this purpose, realistic cargo inspection scenarios have been simulated. PMID:28098841

  3. Compressed Sensing Techniques Applied to Ultrasonic Imaging of Cargo Containers.

    Science.gov (United States)

    López, Yuri Álvarez; Lorenzo, José Ángel Martínez

    2017-01-15

    One of the key issues in the fight against the smuggling of goods has been the development of scanners for cargo inspection. X-ray-based radiographic system scanners are the most developed sensing modality. However, they are costly and use bulky sources that emit hazardous, ionizing radiation. Aiming to improve the probability of threat detection, an ultrasonic-based technique, capable of detecting the footprint of metallic containers or compartments concealed within the metallic structure of the inspected cargo, has been proposed. The system consists of an array of acoustic transceivers that is attached to the metallic structure-under-inspection, creating a guided acoustic Lamb wave. Reflections due to discontinuities are detected in the images, provided by an imaging algorithm. Taking into consideration that the majority of those images are sparse, this contribution analyzes the application of Compressed Sensing (CS) techniques in order to reduce the amount of measurements needed, thus achieving faster scanning, without compromising the detection capabilities of the system. A parametric study of the image quality, as a function of the samples needed in spatial and frequency domains, is presented, as well as the dependence on the sampling pattern. For this purpose, realistic cargo inspection scenarios have been simulated.

  4. Compressed Sensing Techniques Applied to Ultrasonic Imaging of Cargo Containers

    Directory of Open Access Journals (Sweden)

    Yuri Álvarez López

    2017-01-01

    Full Text Available One of the key issues in the fight against the smuggling of goods has been the development of scanners for cargo inspection. X-ray-based radiographic system scanners are the most developed sensing modality. However, they are costly and use bulky sources that emit hazardous, ionizing radiation. Aiming to improve the probability of threat detection, an ultrasonic-based technique, capable of detecting the footprint of metallic containers or compartments concealed within the metallic structure of the inspected cargo, has been proposed. The system consists of an array of acoustic transceivers that is attached to the metallic structure-under-inspection, creating a guided acoustic Lamb wave. Reflections due to discontinuities are detected in the images, provided by an imaging algorithm. Taking into consideration that the majority of those images are sparse, this contribution analyzes the application of Compressed Sensing (CS techniques in order to reduce the amount of measurements needed, thus achieving faster scanning, without compromising the detection capabilities of the system. A parametric study of the image quality, as a function of the samples needed in spatial and frequency domains, is presented, as well as the dependence on the sampling pattern. For this purpose, realistic cargo inspection scenarios have been simulated.

  5. Summary evaluation of the video, {open_quotes}Transportation of radioactive and hazardous materials: Safety for all concerned{close_quotes}

    Energy Technology Data Exchange (ETDEWEB)

    Monroe, M.C.; Young, C.F.

    1993-07-01

    Outreach materials are often developed and distributed without evaluation of their effectiveness. This report provides a glimpse of the effectiveness of one of the US Department of Energy`s videos on transportation of radioactive and hazardous materials. Data from a survey developed by Modern Talking Picture Service, Inc. are summarized. This survey was sent to recipients of the video at three to six weeks after they had received and viewed the video. The response rate is unknown; hence, the results suggest the range of perspectives on the video, rather than the representativeness of those perspectives. The results are also limited by incomplete responses to the survey. Most respondents were middle school and high school teachers who resided throughout the country. Respondents used the video in nearly all school subjects. Most respondents indicated that the video was fairly good and appreciated the factual information, although some saw it as propaganda. Respondents indicated that they would like additional information on hazardous wastes, nuclear power, and transportation. The test crashes were mentioned as a highlight of the video. Recommendations for revising the video and survey are included.

  6. Communication: Cargo towing by artificial swimmers

    Science.gov (United States)

    Debnath, Debajyoti; Ghosh, Pulak K.; Li, Yunyun; Marchesoni, Fabio; Li, Baowen

    2016-11-01

    An active swimmer can tow a passive cargo by binding it to form a self-propelling dimer. The orientation of the cargo relative to the axis of the active dimer's head is determined by the hydrodynamic interactions associated with the propulsion mechanism of the latter. We show how the tower-cargo angular configuration greatly influences the dimer's diffusivity and, therefore, the efficiency of the active swimmer as a micro-towing motor.

  7. 75 FR 5846 - Deadline for Notification of Intent To Use the Airport Improvement Program (AIP) Primary, Cargo...

    Science.gov (United States)

    2010-02-04

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Deadline for Notification of Intent To Use the Airport Improvement Program (AIP) Primary, Cargo, and Nonprimary Entitlement Funds for Fiscal Year 2010 AGENCY: Federal...

  8. 77 FR 19408 - Deadline for Notification of Intent To Use the Airport Improvement Program (AIP) Primary, Cargo...

    Science.gov (United States)

    2012-03-30

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Deadline for Notification of Intent To Use the Airport Improvement Program (AIP) Primary, Cargo, and Nonprimary Entitlement Funds for Fiscal Year 2012 AGENCY: Federal...

  9. 78 FR 20167 - Deadline for Notification of Intent To Use the Airport Improvement Program (AIP) Primary, Cargo...

    Science.gov (United States)

    2013-04-03

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Deadline for Notification of Intent To Use the Airport Improvement Program (AIP) Primary, Cargo, and Nonprimary Entitlement Funds for Fiscal Year 2013 AGENCY: Federal...

  10. Mechanisms for exporting large-sized cargoes from the endoplasmic reticulum.

    Science.gov (United States)

    Saito, Kota; Katada, Toshiaki

    2015-10-01

    Cargo proteins exported from the endoplasmic reticulum to the Golgi apparatus are typically transported in coat protein complex II (COPII)-coated vesicles of 60-90 nm diameter. Several cargo molecules including collagens and chylomicrons form structures that are too large to be accommodated by these vesicles, but their secretion still requires COPII proteins. Here, we first review recent progress on large cargo secretions derived especially from animal models and human diseases, which indicate the importance of COPII proteins. We then discuss the recent isolation of specialized factors that modulate the process of COPII-dependent cargo formation to facilitate the exit of large-sized cargoes from the endoplasmic reticulum. Based on these findings, we propose a model that describes the importance of the GTPase cycle for secretion of oversized cargoes. Next, we summarize reports that describe the structures of COPII proteins and how these results provide insight into the mechanism of assembly of the large cargo carriers. Finally, we discuss what issues remain to be solved in the future.

  11. Early endosomal escape of a cyclic cell-penetrating peptide allows effective cytosolic cargo delivery.

    Science.gov (United States)

    Qian, Ziqing; LaRochelle, Jonathan R; Jiang, Bisheng; Lian, Wenlong; Hard, Ryan L; Selner, Nicholas G; Luechapanichkul, Rinrada; Barrios, Amy M; Pei, Dehua

    2014-06-24

    Cyclic heptapeptide cyclo(FΦRRRRQ) (cFΦR4, where Φ is l-2-naphthylalanine) was recently found to be efficiently internalized by mammalian cells. In this study, its mechanism of internalization was investigated by perturbing various endocytic events through the introduction of pharmacologic agents and genetic mutations. The results show that cFΦR4 binds directly to membrane phospholipids, is internalized into human cancer cells through endocytosis, and escapes from early endosomes into the cytoplasm. Its cargo capacity was examined with a wide variety of molecules, including small-molecule dyes, linear and cyclic peptides of various charged states, and proteins. Depending on the nature of the cargos, they may be delivered by endocyclic (insertion of cargo into the cFΦR4 ring), exocyclic (attachment of cargo to the Gln side chain), or bicyclic approaches (fusion of cFΦR4 and cyclic cargo rings). The overall delivery efficiency (i.e., delivery of cargo into the cytoplasm and nucleus) of cFΦR4 was 4-12-fold higher than those of nonaarginine, HIV Tat-derived peptide, or penetratin. The higher delivery efficiency, coupled with superior serum stability, minimal toxicity, and synthetic accessibility, renders cFΦR4 a useful transporter for intracellular cargo delivery and a suitable system for investigating the mechanism of endosomal escape.

  12. The Arteries of Global Trade: Industrial Restructuring and Technological Change in the Transatlantic Air Cargo Industry

    Science.gov (United States)

    Schwarz, Guido

    2010-01-01

    Air cargo enjoys a special importance: together with maritime transport it is the backbone of global trade and is indispensable for contemporary globalization. Air transport is the only mode that combines worldwide reach with high speed. Nonetheless there is a dearth of geographic research that analyzes the current restructuring affecting the air…

  13. 46 CFR 154.1834 - Cargo transfer piping.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Cargo transfer piping. 154.1834 Section 154.1834... piping. The person in charge of cargo transfer shall ensure that cargo is transferred to or from a cargo tank only through the cargo piping system....

  14. 46 CFR 153.910 - Cargo piping plan.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Cargo piping plan. 153.910 Section 153.910 Shipping... Information § 153.910 Cargo piping plan. No person may operate a tankship unless the tankship has a cargo piping plan that: (a) Shows all cargo piping on the tankship; (b) Shows all cargo valving, pumps,...

  15. 46 CFR 154.554 - Cargo hose: Bursting pressure.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Cargo hose: Bursting pressure. 154.554 Section 154.554... Hose § 154.554 Cargo hose: Bursting pressure. Cargo hose that may be exposed to the pressure in the cargo tank, the cargo pump discharge, or the vapor compressor discharge must have a bursting pressure of...

  16. Revival of the airship. An outlook for the possibilities to re-introduce the airship for passengers and cargo transport in the Netherlands; Revival van het luchtschip. Een verkenning naar de mogelijkheden van een herinvoering van het luchtschip voor passagiers en vrachtvervoer in Nederland

    Energy Technology Data Exchange (ETDEWEB)

    Peeters, P.M.; Tensen, D.K.; Sleurink, M.; Van Timmeren, A. [Peeters Advies, Haarlem (Netherlands)

    1996-09-01

    The main question in the detailed title study is whether airships can be an alternative for high-speed trains and the short-distance air traffic or will the use be restricted to niche markets. The study is subdivided into three parts: (1) technical characteristics of airships, based on a literature study, interviews with experts in the field, and a calculation scheme to gain insight into the relation between different parameters that determine the characteristics of airships; (2) the spatial fitting in of airships: everything that is necessary to land and to start the airship, also based on a literature study, interviews with experts in the field and a desk study; an (3) the market for airships for transport of passengers or cargo. 49 refs.

  17. Variable Structure Control of Catastrophic Course in Airdropping Heavy Cargo

    Institute of Scientific and Technical Information of China (English)

    Zhang Huiyuan; Shi Zhongke

    2009-01-01

    The mathematical model of a transport aircraft would be subjected to a sudden change when heavy cargo is dropped off in airdropping, which exerts serious influences upon the safety of the aircraft. A variable structure controller is specially designed for handling the airdrop process. The nonlinear system is linearized by input-output feedback linearization using differential geometry theories. On this basis, an inner loop system for velocity and attitude tracking control is designed by using the exponentially approaching rule of the variable structure theory. The whole flight control system is integrated with the outer loop flight altitude control. Digital simulation evidences the applicability of the system to potentially catastrophic course in airdropping heavy cargo and provides robustness against system parameter perturbation.

  18. Implementation of cargo MagLev in the United States

    Energy Technology Data Exchange (ETDEWEB)

    Rose, Chris R [Los Alamos National Laboratory; Peterson, Dean E [Los Alamos National Laboratory; Leung, Eddie M [MAGTEC ENGINEERING

    2008-01-01

    Numerous studies have been completed in the United States, but no commercial MagLev systems have been deployed. Outside the U.S., MagLev continues to attract funding for research, development and implementation. A brief review of recent global developments in MagLev technology is given followed by the status of MagLev in the U.S. The paper compares the cost of existing MagLev systems with other modes of transport, notes that the near-term focus of MagLev development in the U.S. should be for cargo, and suggests that future MagLev systems should be for very high speed cargo. The Los Angeles to Port of Los Angeles corridor is suggested as a first site for implementation. The benefits of MagLev are described along with suggestions on how to obtain funding.

  19. The Influence of Freight Trains on the Air Cargo in Kuwait International Airport

    Directory of Open Access Journals (Sweden)

    Fadala Hassan Alfadala

    2017-03-01

    Full Text Available Surrounded by countries who are moving continually towards economic development and stability, Kuwait has moved to establishing freight trains on the Air Cargo in Kuwait International Airport to meet the ever changing and increasing number of both passenger and cargoes going in and out of the country. As a member of the Gulf Cooperation Council or GCC it is clearly seen that as most of its member countries drive towards a collective effort to connect together by means of railroad networks, Kuwait’s effort to move transportation of cargoes to and from the Kuwait International Airport by linking with the GCC’s project to create railroad networks, the proposed ―Cargo City‖ becomes a major part of the realization of the development of the KIA which shall help with the aim to widen trade within and across GCC countries.

  20. LUCID: A Quantitative Assay of ESCRT-Mediated Cargo Sorting into Multivesicular Bodies.

    Science.gov (United States)

    Nickerson, Daniel P; Merz, Alexey J

    2015-12-01

    Endosomes are transportation nodes, mediating selective transport of soluble and transmembrane cargos to and from the Golgi apparatus, plasma membrane and lysosomes. As endosomes mature to become multivesicular bodies (MVBs), Endosomal Sorting Complexes Required for Transport (ESCRTs) selectively incorporate transmembrane cargos into vesicles that bud into the endosome lumen. Luminal vesicles and their cargoes are targeted for destruction when MVBs fuse with lysosomes. Common assays of endosomal luminal targeting, including fluorescence microscopy and monitoring of proteolytic cargo maturation, possess significant limitations. We present a quantitative assay system called LUCID (LUCiferase reporter of Intraluminal Deposition) that monitors exposure of chimeric luciferase-cargo reporters to cytosol. Luciferase-chimera signal increases when sorting to the endosome lumen is disrupted, and silencing of signal from the chimera depends upon luminal delivery of the reporter rather than proteolytic degradation. The system presents several advantages, including rapidity, microscale operation and a high degree of reproducibility that enables detection of subtle phenotypic differences. Luciferase reporters provide linear signal over an extremely broad dynamic range, allowing analysis of reporter traffic even at anemic levels of expression. Furthermore, LUCID reports transport kinetics when applied to inducible trafficking reporters.

  1. Hazardous Waste: Learn the Basics of Hazardous Waste

    Science.gov (United States)

    ... page on hazardous waste transportation . Top of Page Hazardous Waste Recycling, Treatment, Storage and Disposal To the extent possible, EPA ... Disposal Facilities (TSDFs) provide temporary storage and final treatment or disposal for hazardous wastes. Since they manage large volumes of waste and ...

  2. Hazardous Waste

    Science.gov (United States)

    ... you throw these substances away, they become hazardous waste. Some hazardous wastes come from products in our homes. Our garbage can include such hazardous wastes as old batteries, bug spray cans and paint ...

  3. 46 CFR 154.1810 - Cargo manual.

    Science.gov (United States)

    2010-10-01

    ... vaporization system. (v) Gas main system. (vi) Cargo tank or compressor relief system and blocked liquid or gas relief system. (vii) Inerting system. (viii) Boil-off gas compressor or reliquefaction system. (ix) Gas... SELF-PROPELLED VESSELS CARRYING BULK LIQUEFIED GASES Operations § 154.1810 Cargo manual. (a) No person...

  4. 49 CFR 383.121 - Requirements for hazardous materials endorsement.

    Science.gov (United States)

    2010-10-01

    ... hazardous materials accidents; and (10) Tunnels and railroad crossings. (b) Hazardous materials handling...; (7) Routes; (8) Cargo Tanks; and (9) “Safe Havens.” (c) Operation of emergency equipment including... materials laden motor vehicle; and (4) Use of emergency equipment for tank vehicles. (d) Emergency...

  5. Optimization for Hazardous Material Road Transportation Based on Multi-objective Method%危险品的多目标运输路径优化研究

    Institute of Scientific and Technical Information of China (English)

    刘慧怡

    2013-01-01

    由于危险品运输的特殊性质,在危险品运输路径选择过程中,需要考虑更多的因素,因此提出基于多目标的路径优化模型,通过运输风险、危险平均后果及总后果全面考虑运输中的危险,并将风险、运距及费用目标抽象得到类似广义费用的综合表达形式,使得影响因素影响程度的确定具有更强的灵活性以及适用性;对于综合目标模型采用Dijkstra算法求解,该方法简便易算具有很强操作性,最后用算例验证了方法的科学可行性.%As for hazardous material road transportation,due to its special quality and susceptible to be affected by more factors,this paper propose a model based on multi-objective optimization.By weighting each objective to get a similar generalized cost expression,makes the function of influencing factors more flexibility and applicability; and by applying global optimization algorithm to optimize the path,this method is simple and easy to be calculated,which will provide a more operable model for the optimization problem of hazardous material road transportation.Finally,the feasibility of the method is proved by the given example.

  6. PDE6δ-mediated sorting of INPP5E into the cilium is determined by cargo-carrier affinity.

    Science.gov (United States)

    Fansa, Eyad Kalawy; Kösling, Stefanie Kristine; Zent, Eldar; Wittinghofer, Alfred; Ismail, Shehab

    2016-04-11

    The phosphodiesterase 6 delta subunit (PDE6δ) shuttles several farnesylated cargos between membranes. The cargo sorting mechanism between cilia and other compartments is not understood. Here we show using the inositol polyphosphate 5'-phosphatase E (INPP5E) and the GTP-binding protein (Rheb) that cargo sorting depends on the affinity towards PDE6δ and the specificity of cargo release. High-affinity cargo is exclusively released by the ciliary transport regulator Arl3, while low-affinity cargo is released by Arl3 and its non-ciliary homologue Arl2. Structures of PDE6δ/cargo complexes reveal the molecular basis of the sorting signal which depends on the residues at the -1 and -3 positions relative to farnesylated cysteine. Structure-guided mutation allows the generation of a low-affinity INPP5E mutant which loses exclusive ciliary localization. We postulate that the affinity to PDE6δ and the release by Arl2/3 in addition to a retention signal are the determinants for cargo sorting and enrichment at its destination.

  7. Project CarGO tram at Dresden; Projekt CarGo Tram in Dresden

    Energy Technology Data Exchange (ETDEWEB)

    Mueller-Eberstein, F.; Franke, M. [Dresdner Verkehrsbetriebe AG, Dresden (Germany)

    2000-05-01

    Next year, the Glassen Volkswagen Factory, which is currently under construction, will commence the production of luxury class automobiles. Already buying a car is meant to be a special event; thus the factory is set in a baroque environment, near the famous Semper Opera and Picture Gallery. This arrangement, hitherto without example, will be accompanied by another, equally remarkable project. The factory, which is situated in a central city area being very sensitive in terms of urban development and traffic installations, will be delivered raw materials and parts using a CarGo Tram. Two bi-directionally operated, 60 metres long five-car trains will transport the parts from the railway cargo hub at Dresden Friedrichstadt to the factory in cycles of 40 minutes. There and at the Glassen Factory in Grosser Garten, separate track terminals will be built. In addition to the historic past and the charming scenery of the Elbe metropolis Dresden and its environs, soon also the CarGo Tram and the Glassen Factory will attract guests from all over the world to visit this innovative and culturally important city in the centre of Europe. (orig.) [German] Im Jahr 2001 beginnt die Produktion von Automobilen der Oberklasse in der derzeit noch im Bau befindlichen Glaesernen Manufaktur der Volkswagen Automobil-Manufaktur Dresden GmbH. In einem barocken Umfeld, mit raeumlicher Naehe zur Semperoper und Gemaeldegalerie, soll bereits der Verkauf dieser Fahrzeuge zu einem Erlebnis werden. Dieses bisher einmalige Vorhaben wird von einem zweiten, ebenso einzigartigen Vorhaben begleitet. Die Belieferung der in einem staedtebaulich und verkehrlich sensiblen Innenstadtbereich gelegenen Manufaktur erfolgt mit einer Gueterstrassenbahn. Zwei 60 Meter lange, fuenfteilige Zweirichtungsfahrzeuge werden ab Maerz 2001 etwa im 40-Minutentakt die Anlieferung der Zulieferteile aus dem Gueterverkehrszentrum Dresden-Friedrichstadt uebernehmen. Hier und an der Glaesernen Manufaktur im Grossen Garten werden

  8. Accidents on vessels transporting liquid gases and responder's concerns : the Galerne Project

    Energy Technology Data Exchange (ETDEWEB)

    Cabioc' h, F. [Centre de Documentation, de Recherche et d' Experimentations, Brest (France); De Castelet, D. [Veritas, Paris (France); Penelon, T.; Pagnon, S. [Ineris, Verneuil en Halatte (France); Peuch, A.; Bonnardot, F. [Meteo France, Toulouse (France); Duhart, J. [GdF-Suez, Paris (France); Drevet, D. [French Ministry of Transport, Paris (France). Sea Accident Investigation Bureau; Cerutti, C. [French Navy, Brest (France); Estiez, C. [French Civil Security, Paris (France); Dernat, M. [Total Gaz and New Energy, Paris (France); Hermand, J.C. [Total PetroChemicals, Paris (France)

    2009-07-01

    In 2006, the French Ministry of Research financed the Galerne project to provide responders at sea with relevant information on the hazards posed by liquid gas chemicals on vessels disabled at sea. Thirty-one chemicals are transported as liquids in order to facilitate handling and lower transport costs. Temperature and pressure parameters are manipulated in order to generate the liquefaction of the gases. Members of the Galerne project are producers and handlers of liquefied gases and are experts in atmospheric modelling, ship structure, risk assessment, hazards assessment and operations. Several simulations and experiments were performed in an effort to produce operational information for responders and headquarters. For practical and financial reasons, it was not possible to consider all 31 chemicals described in the IGC code. Only 4 liquid gases were chosen for the Galerne project, notably methane liquefied natural gas (LNG); propane LNG; ammonia; and vinyl chloride monomer (VCM). They were chosen on the basis of their transport characteristics and behaviour. This paper outlined the physical characteristics of the transported products verses their volume in standard conditions; the type of ship dedicated to transporting gases in liquid forms; and various response phases. It also included a brief review of several ship incidents and accidents. It was concluded that as far as the LNG carriers are concerns, a few accidents at sea have occurred in more than 28 years, but no major accidents involving the cargo have been reported. Handling LNG at terminals can lead to serious accidents. Accidents have occurred at sea, but without any accidental spillage of cargo. It was concluded that response teams on-board disabled liquefied gas carriers need to know the main characteristics of the cargo and the potential hazards. 3 tabs., 6 figs.

  9. "Cargo-mooring" as an operating principle for molecular motors.

    Science.gov (United States)

    Lisowski, Bartosz; Kuśmierz, Łukasz; Żabicki, Michał; Bier, Martin

    2015-06-07

    Navigating through an ever-changing and unsteady environment, and utilizing chemical energy, molecular motors transport the cell׳s crucial components, such as organelles and vesicles filled with neurotransmitter. They generate force and pull cargo, as they literally walk along the polymeric tracks, e.g. microtubules. What we suggest in this paper is that the motor protein is not really pulling its load. The load is subject to diffusion and the motor may be doing little else than rectifying the fluctuations, i.e. ratcheting the load׳s diffusion. Below we present a detailed model to show how such ratcheting can quantitatively account for observed data. The consequence of such a mechanism is the dependence of the transport׳s speed and efficacy not only on the motor, but also on the cargo (especially its size) and on the environment (i.e. its viscosity and structure). Current experimental works rarely provide this type of information for in vivo studies. We suggest that even small differences between assays can impact the outcome. Our results agree with those obtained in wet laboratories and provide novel insight in a molecular motor׳s functioning.

  10. 46 CFR 154.500 - Cargo and process piping standards.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Cargo and process piping standards. 154.500 Section 154... Equipment Cargo and Process Piping Systems § 154.500 Cargo and process piping standards. The cargo liquid and vapor piping and process piping systems must meet the requirements in §§ 154.503 through...

  11. 46 CFR 98.30-11 - Cargo pumps.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Cargo pumps. 98.30-11 Section 98.30-11 Shipping COAST..., ARRANGEMENT, AND OTHER PROVISIONS FOR CERTAIN DANGEROUS CARGOES IN BULK Portable Tanks § 98.30-11 Cargo pumps. No person may operate a cargo pump to transfer a product to or from a portable tank unless the...

  12. 46 CFR 105.20-3 - Cargo tanks.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Cargo tanks. 105.20-3 Section 105.20-3 Shipping COAST... VESSELS DISPENSING PETROLEUM PRODUCTS Specific Requirements-Cargo Tanks § 105.20-3 Cargo tanks. (a) Construction and Materials. (1) The cargo tanks must be constructed of iron, steel, copper, nickel...

  13. 46 CFR 153.935a - Storage of cargo samples.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Storage of cargo samples. 153.935a Section 153.935a Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES SHIPS... § 153.935a Storage of cargo samples. (a) The master shall make sure that any cargo samples are stored...

  14. 19 CFR 122.115 - Labeling of cargo.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Labeling of cargo. 122.115 Section 122.115 Customs... AIR COMMERCE REGULATIONS Transit Air Cargo Manifest (TACM) Procedures § 122.115 Labeling of cargo. A warning label, as required by § 18.4(e) of this chapter, shall be attached to all transit air cargo...

  15. 19 CFR 4.38 - Release of cargo.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Release of cargo. 4.38 Section 4.38 Customs Duties... VESSELS IN FOREIGN AND DOMESTIC TRADES Landing and Delivery of Cargo § 4.38 Release of cargo. (a) No... report which lists those shipments which have been authorized for release. This alternative cargo...

  16. 19 CFR 4.33 - Diversion of cargo.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Diversion of cargo. 4.33 Section 4.33 Customs... VESSELS IN FOREIGN AND DOMESTIC TRADES Landing and Delivery of Cargo § 4.33 Diversion of cargo. (a) Unlading at other than original port of destination. A vessel may unlade cargo or baggage at an...

  17. 46 CFR 153.977 - Supervision of cargo transfer.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Supervision of cargo transfer. 153.977 Section 153.977 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES SHIPS... Procedures § 153.977 Supervision of cargo transfer. The person in charge of cargo transfer shall:...

  18. 46 CFR 154.552 - Cargo hose: Compatibility.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Cargo hose: Compatibility. 154.552 Section 154.552 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES SAFETY... Hose § 154.552 Cargo hose: Compatibility. Liquid and vapor cargo hoses must: (a) Not chemically...

  19. 46 CFR 154.412 - Cargo tank corrosion allowance.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Cargo tank corrosion allowance. 154.412 Section 154.412... Containment Systems § 154.412 Cargo tank corrosion allowance. A cargo tank must be designed with a corrosion...) carries a cargo that corrodes the tank material. Note: Corrosion allowance for independent tank type C...

  20. Design of heavy lift cargo aircraft

    Data.gov (United States)

    National Aeronautics and Space Administration — This is the bird of the skies of the future. The heavy lift cargo aircraft which is currently being developed by me has twice the payload capacity of an Antonov...

  1. Transportation

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — The National Flood Hazard Layer (NFHL) data incorporates all Digital Flood Insurance Rate Map(DFIRM) databases published by FEMA, and any Letters Of Map Revision...

  2. Building Programs Seminar of Hazardous Chemicals Transportation Safety Services Platform%危化品运输安全服务平台的建设方案研讨

    Institute of Scientific and Technical Information of China (English)

    谢枭

    2011-01-01

    为了提高危化品运输的安全服务水平,本文提出了危化品运输安全服务系统建设思路,研究了建设集中的大型危化品运输安全服务平台的设计方案,从而为企业和政府监管单位设计和建设大型危化品公路运输安全服务平台提供了参考。%In order to improve the safety of hazardous goods transport services,this paper presents a hazardous material transportation security service system building ideas,study focused on the construction of large-scale hazardous material transportation security services platform design, so as to corporate and government regulatory units design and construction of large-scale road transport of hazardous chemicals to provide a reference platform security services.

  3. Software For Nearly Optimal Packing Of Cargo

    Science.gov (United States)

    Fennel, Theron R.; Daughtrey, Rodney S.; Schwaab, Doug G.

    1994-01-01

    PACKMAN computer program used to find nearly optimal arrangements of cargo items in storage containers, subject to such multiple packing objectives as utilization of volumes of containers, utilization of containers up to limits on weights, and other considerations. Automatic packing algorithm employed attempts to find best positioning of cargo items in container, such that volume and weight capacity of container both utilized to maximum extent possible. Written in Common LISP.

  4. Cargo binding promotes KDEL receptor clustering at the mammalian cell surface.

    Science.gov (United States)

    Becker, Björn; Shaebani, M Reza; Rammo, Domenik; Bubel, Tobias; Santen, Ludger; Schmitt, Manfred J

    2016-06-29

    Transmembrane receptor clustering is a ubiquitous phenomenon in pro- and eukaryotic cells to physically sense receptor/ligand interactions and subsequently translate an exogenous signal into a cellular response. Despite that receptor cluster formation has been described for a wide variety of receptors, ranging from chemotactic receptors in bacteria to growth factor and neurotransmitter receptors in mammalian cells, a mechanistic understanding of the underlying molecular processes is still puzzling. In an attempt to fill this gap we followed a combined experimental and theoretical approach by dissecting and modulating cargo binding, internalization and cellular response mediated by KDEL receptors (KDELRs) at the mammalian cell surface after interaction with a model cargo/ligand. Using a fluorescent variant of ricin toxin A chain as KDELR-ligand (eGFP-RTA(H/KDEL)), we demonstrate that cargo binding induces dose-dependent receptor cluster formation at and subsequent internalization from the membrane which is associated and counteracted by anterograde and microtubule-assisted receptor transport to preferred docking sites at the plasma membrane. By means of analytical arguments and extensive numerical simulations we show that cargo-synchronized receptor transport from and to the membrane is causative for KDELR/cargo cluster formation at the mammalian cell surface.

  5. Characterizing X-ray Attenuation of Containerized Cargo

    Energy Technology Data Exchange (ETDEWEB)

    Birrer, N. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Divin, C. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Glenn, S. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Martz, H. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Wang, G. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2016-08-02

    X-ray inspection systems can be used to detect radiological and nuclear threats in imported cargo. In order to better understand performance of these systems, the attenuation characteristics of imported cargo need to be determined. This project focused on developing image processing algorithms for segmenting cargo and using x-ray attenuation to quantify equivalent steel thickness to determine cargo density. These algorithms were applied to over 450 cargo radiographs. The results are summarized in this report.

  6. 76 FR 5586 - California State Motor Vehicle and Nonroad Engine Pollution Control Standards; Mobile Cargo...

    Science.gov (United States)

    2011-02-01

    ... Equipment). CARB's Mobile Cargo Handling Equipment requirements are designed to use best available control... Alexander at (202) 343-9540, to learn if a hearing will be held or may check the following webpage for an... restricted by statute. EPA's Office of Transportation and Air Quality also maintains a webpage that...

  7. 78 FR 64285 - National Maritime Strategy Symposium: Cargo Opportunities and Sealift Capacity

    Science.gov (United States)

    2013-10-28

    ... Marine Transportation System stakeholders to participate in a discussion intended to develop a robust...'s cargo opportunities and sealift capacity while ensuring future sustainability. Speaker and topic... of global business and employment opportunities for the Nation; and fostering the construction and...

  8. 46 CFR 308.549 - Application for appointment of Cargo Underwriting Agent, Form MA-319.

    Science.gov (United States)

    2010-10-01

    ..., Form MA-319. 308.549 Section 308.549 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION... appointment of Cargo Underwriting Agent, Form MA-319. Any domestic insurance company authorized to do a marine... by submitting to the Maritime Administrator a letter and Form MA-399, which may be obtained from...

  9. Indications of marine bioinvasion from network theory. An analysis of the global cargo ship network

    NARCIS (Netherlands)

    Kölzsch, A.; Blasius, B.

    2011-01-01

    The transport of huge amounts of small aquatic organisms in the ballast tanks and at the hull of large cargo ships leads to ever increasing rates of marine bioinvasion. In this study, we apply a network theoretic approach to examine the introduction of invasive species into new ports by global shipp

  10. Chute System Research in Stone Transportation of Hazardous Rock Cutting%危岩体削方石料转运溜槽系统研究

    Institute of Scientific and Technical Information of China (English)

    谢全敏; 王红彬; 吴勇

    2011-01-01

    溜槽系统是山体开采中一种经济、安全的运输方式,它的优越性已逐渐被人们意识到,但其理论研究十分稀少,特别是溜槽系统的设计无相关理论和规范可参考.为此,研究了岩块在溜槽系统中的运动形式、运动速度和飞跃距离,并在此基础之上,以黄石市板岩山危岩体削方工程为例,探讨了溜槽系统在危岩体削方石料转运中的应用.溜槽系统充分利用了地形高差大的特点,节约了石料运输成本,加快了施工进程,有较好的推广前景和参考价值.%Chute system is a kind of economic and safe mode of transportation in mountain exploitation. Although having realized its advantages, people study rarely about its theories. In particular, there aren't related theories and standards in its designs. For this reason, the article studies about the form, velocity and flying distance of rock moving in chute system. And basing on this, taking Banyan Mountain hazardous rock cutting for example, the article discusses application of chute system. Chute system makes full use of the characteristic of large altitude difference. The fact shows that, it not only saves transportation cost, but also accelerates construction progress. Chute system has better spreading prospect and reference value.

  11. THE ANALYSIS OF WAYS TO IMPROVE ECONOMIC DEVELOPMENT AND TRADE ORGANIZATION OF TRANSPORTATION ON AIR TRANSPORT

    Directory of Open Access Journals (Sweden)

    I. A. Ivanov

    2015-01-01

    Full Text Available In transport system of Russia air transport is one of main types of passenger and cargo transport. Demand for air transportation constantly increases that allows to consider reasonably improvement of transportations on air transport as the priority direction of development in civil aviation. The article considers issues of development of the branch air transport.

  12. Research on probability distribution of port cargo throughput

    Institute of Scientific and Technical Information of China (English)

    SUN Liang; TAN De-rong

    2008-01-01

    In order to more accurately examine developing trends in gross cargo throughput, we have modeled the probability distribution of cargo throughput. Gross cargo throughput is determined by the time spent by cargo ships in the port and the operating efficiency of handling equipment. Gross cargo throughput is the sum of all compound variables determining each aspect of cargo throughput for every cargo ship arriving at the port. Probability distribution was determined using the Wald equation. The results show that the variability of gross cargo throughput primarily depends on the different times required by different cargo ships arriving at the port. This model overcomes the shortcoming of previous models: inability to accurately determine the probability of a specific value of future gross cargo throughput. Our proposed model of cargo throughput depends on the relationship between time required by a cargo ship arriving at the port and the operational capacity of handling equipment at the port. At the same time, key factors affecting gross cargo throughput are analyzed. In order to test the efficiency of the model, the cargo volume of a port in Shandong Province was used as an example. In the case study the actual results matched our theoretical analysis.

  13. Uncertainty Quantification for Cargo Hold Fires

    CERN Document Server

    DeGennaro, Anthony M; Martinelli, Luigi; Rowley, Clarence W

    2015-01-01

    The purpose of this study is twofold -- first, to introduce the application of high-order discontinuous Galerkin methods to buoyancy-driven cargo hold fire simulations, second, to explore statistical variation in the fluid dynamics of a cargo hold fire given parameterized uncertainty in the fire source location and temperature. Cargo hold fires represent a class of problems that require highly-accurate computational methods to simulate faithfully. Hence, we use an in-house discontinuous Galerkin code to treat these flows. Cargo hold fires also exhibit a large amount of uncertainty with respect to the boundary conditions. Thus, the second aim of this paper is to quantify the resulting uncertainty in the flow, using tools from the uncertainty quantification community to ensure that our efforts require a minimal number of simulations. We expect that the results of this study will provide statistical insight into the effects of fire location and temperature on cargo fires, and also assist in the optimization of f...

  14. Optimization of the air cargo supply chain

    Directory of Open Access Journals (Sweden)

    María Pérez Bernal

    2012-10-01

    Full Text Available Purpose: This paper aims to evaluate and optimize the various operations within the air cargo chain. It pursues to improve the efficiency of the air cargo supply chain and to provide more information to the decision-makers to optimize their fields.Design/methodology/approach: The method used is a process simulation modelling software, WITNESS, which provides information to the decision-makers about the most relevant parameters subject to optimization. The input for the simulation is obtained from a qualitative analysis of the air cargo supply chain with the involved agents and from a study of the external trade by air mode, given that their behaviour depend on the location. The case study is focused on a particular location, the Case of Zaragoza Airport (Spain.Findings: This paper demonstrates that efficiency of the air cargo supply chain can increase by leveraging several parameters such as bottlenecks, resources or warehouses.Originality/value: It explores the use of a simulation modeling software originally intended for manufacturing processes and extended to support decision making processes in the area of air cargo.

  15. Solar-electric-propulsion cargo vehicles for split/sprint Mars mission

    Science.gov (United States)

    Callaghan, Christopher E.; Crowe, Michael D.; Swis, Matthew J.; Mickney, Marcus R.; Montgomery, C. Keith; Walters, Robert; Thoden, Scott

    1991-01-01

    In support of the proposed exploration of Mars, an unmanned cargo ferry SEMM1 (Solar Electric Mars Mission) was designed. The vehicle is based on solar electric propulsion, and required to transport a cargo of 61,000 kg. The trajectory is a combination of spirals; first, out from LEO, then around the sun, then spiral down to low Mars orbit. The spacecraft produces 3.03 MWe power using photovoltaic flexible blanket arrays. Ion thrusters using argon as a propellant were selected to drive the ship, providing about 60 Newtons of thrust in low Earth orbit. The configuration is based on two long truss beams to which the 24 individual, self-deployable, solar arrays are attached. The main body module supports the two beams and houses the computers, electrical, and control equipment. The thruster module is attached to the rear of the main body, and the cargo to the front.

  16. 75 FR 14160 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2010-03-24

    ...-Operating Common Carrier and Ocean Freight Forwarder--Ocean Transportation Intermediary pursuant to section...-Vessel-Operating Common Carrier and Ocean Freight Forwarder Transportation Intermediary: Reliable... Freight Forwarder--Ocean Transportation Intermediary: Jeffery Raymond Sewell dba Cargo Unlimited Worldwide...

  17. 49 CFR 171.3 - Hazardous waste.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Hazardous waste. 171.3 Section 171.3... waste. (a) No person may offer for transportation or transport a hazardous waste (as defined in § 171.8... waste for which a manifest is required unless that person: (1) Has marked each motor vehicle used to...

  18. Cargo binding to Atg19 unmasks additional Atg8 binding sites to mediate membrane-cargo apposition during selective autophagy.

    Science.gov (United States)

    Sawa-Makarska, Justyna; Abert, Christine; Romanov, Julia; Zens, Bettina; Ibiricu, Iosune; Martens, Sascha

    2014-05-01

    Autophagy protects cells from harmful substances such as protein aggregates, damaged mitochondria and intracellular pathogens, and has been implicated in a variety of diseases. Selectivity of autophagic processes is mediated by cargo receptors that link cargo to Atg8 family proteins on the developing autophagosomal membrane. To avoid collateral degradation during constitutive autophagic pathways, the autophagic machinery must not only select cargo but also exclude non-cargo material. Here we show that cargo directly activates the cargo receptor Atg19 by exposing multiple Atg8 binding sites. Furthermore, Atg19 mediates tight apposition of the cargo and Atg8-coated membranes in a fully reconstituted system. These properties are essential for the function of Atg19 during selective autophagy in vivo. Our results suggest that cargo receptors contribute to tight membrane bending of the isolation membrane around the cargo.

  19. Characterizing Complexity of Containerized Cargo X-ray Images

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Guangxing [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Martz, Harry [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Glenn, Steven [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Divin, Charles [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Birrer, Nat [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2016-08-19

    X-ray imaging can be used to inspect cargos imported into the United States. In order to better understand the performance of X-ray inspection systems, the X-ray characteristics (density, complexity) of cargo need to be quantified. In this project, an image complexity measure called integrated power spectral density (IPSD) was studied using both DNDO engineered cargos and stream-of-commerce (SOC) cargos. A joint distribution of cargo density and complexity was obtained. A support vector machine was used to classify the SOC cargos into four categories to estimate the relative fractions.

  20. Drive the Car(go)s-New Modalities to Control Cargo Trafficking in Live Cells.

    Science.gov (United States)

    Mondal, Payel; Khamo, John S; Krishnamurthy, Vishnu V; Cai, Qi; Zhang, Kai

    2017-01-01

    Synaptic transmission is a fundamental molecular process underlying learning and memory. Successful synaptic transmission involves coupled interaction between electrical signals (action potentials) and chemical signals (neurotransmitters). Defective synaptic transmission has been reported in a variety of neurological disorders such as Autism and Alzheimer's disease. A large variety of macromolecules and organelles are enriched near functional synapses. Although a portion of macromolecules can be produced locally at the synapse, a large number of synaptic components especially the membrane-bound receptors and peptide neurotransmitters require active transport machinery to reach their sites of action. This spatial relocation is mediated by energy-consuming, motor protein-driven cargo trafficking. Properly regulated cargo trafficking is of fundamental importance to neuronal functions, including synaptic transmission. In this review, we discuss the molecular machinery of cargo trafficking with emphasis on new experimental strategies that enable direct modulation of cargo trafficking in live cells. These strategies promise to provide insights into a quantitative understanding of cargo trafficking, which could lead to new intervention strategies for the treatment of neurological diseases.

  1. Drive the Car(go)s—New Modalities to Control Cargo Trafficking in Live Cells

    Science.gov (United States)

    Mondal, Payel; Khamo, John S.; Krishnamurthy, Vishnu V.; Cai, Qi; Zhang, Kai

    2017-01-01

    Synaptic transmission is a fundamental molecular process underlying learning and memory. Successful synaptic transmission involves coupled interaction between electrical signals (action potentials) and chemical signals (neurotransmitters). Defective synaptic transmission has been reported in a variety of neurological disorders such as Autism and Alzheimer’s disease. A large variety of macromolecules and organelles are enriched near functional synapses. Although a portion of macromolecules can be produced locally at the synapse, a large number of synaptic components especially the membrane-bound receptors and peptide neurotransmitters require active transport machinery to reach their sites of action. This spatial relocation is mediated by energy-consuming, motor protein-driven cargo trafficking. Properly regulated cargo trafficking is of fundamental importance to neuronal functions, including synaptic transmission. In this review, we discuss the molecular machinery of cargo trafficking with emphasis on new experimental strategies that enable direct modulation of cargo trafficking in live cells. These strategies promise to provide insights into a quantitative understanding of cargo trafficking, which could lead to new intervention strategies for the treatment of neurological diseases. PMID:28163671

  2. 实货制条件下货运站装卸能力适应性研究%Study on Adaptability of Cargo Terminal Loading/unloading Capacity under Cargo Registration System

    Institute of Scientific and Technical Information of China (English)

    程堪弟; 殷勇

    2016-01-01

    随着“实货制”货运站装卸作业方式的转变,货运站如何实现白货的装卸、配载是个棘手问题,加上我国铁路现有的货运装卸方法存在一定的不适应性等问题,导致货运站装卸能力严重紧张不足。结合我国货物运输组织改革及主要货运站能力现状,确定影响货运站装卸效率主要因素,进一步提出改进实货制条件下货运站装卸能力适应性的保障措施。%The implementation of the cargo registration system has transformed the activity mode of the cargo terminals and moreover the loading/unloading process of the railway system in China is still misaligned with the cargo registration system, leading to severe shortage of the loading/unloading capacity of the cargo terminals. In this paper, in view of the reform initiative of the cargo transportation organizations in China and the current status of the capacity of the major cargo terminals, we determined the major factors affecting the loading/unloading efficiency of the cargo terminals and then further proposed the measures to improve the adaptability of the cargo terminals with the cargo registration system.

  3. National Security Science and Technology Initiative: Air Cargo Screening

    Energy Technology Data Exchange (ETDEWEB)

    Bingham, Philip R [ORNL; White, Tim [Pacific Northwest National Laboratory (PNNL); Cespedes, Ernesto [Idaho National Laboratory (INL); Bowerman, Biays [Brookhaven National Laboratory (BNL); Bush, John [Battelle

    2010-11-01

    The non-intrusive inspection (NII) of consolidated air cargo carried on commercial passenger aircraft continues to be a technically challenging, high-priority requirement of the Department of Homeland Security's Science and Technology Directorate (DHS S&T), the Transportation Security Agency and the Federal Aviation Administration. The goal of deploying a screening system that can reliably and cost-effectively detect explosive threats in consolidated cargo without adversely affecting the flow of commerce will require significant technical advances that will take years to develop. To address this critical National Security need, the Battelle Memorial Institute (Battelle), under a Cooperative Research and Development Agreement (CRADA) with four of its associated US Department of Energy (DOE) National Laboratories (Oak Ridge, Pacific Northwest, Idaho, and Brookhaven), conducted a research and development initiative focused on identifying, evaluating, and integrating technologies for screening consolidated air cargo for the presence of explosive threats. Battelle invested $8.5M of internal research and development funds during fiscal years 2007 through 2009. The primary results of this effort are described in this document and can be summarized as follows: (1) Completed a gap analysis that identified threat signatures and observables, candidate technologies for detection, their current state of development, and provided recommendations for improvements to meet air cargo screening requirements. (2) Defined a Commodity/Threat/Detection matrix that focuses modeling and experimental efforts, identifies technology gaps and game-changing opportunities, and provides a means of summarizing current and emerging capabilities. (3) Defined key properties (e.g., elemental composition, average density, effective atomic weight) for basic commodity and explosive benchmarks, developed virtual models of the physical distributions (pallets) of three commodity types and three

  4. National Security Science and Technology Initiative: Air Cargo Screening

    Energy Technology Data Exchange (ETDEWEB)

    Bingham, Philip R [ORNL; White, Tim [Pacific Northwest National Laboratory (PNNL); Cespedes, Ernesto [Idaho National Laboratory (INL); Bowerman, Biays [Brookhaven National Laboratory (BNL); Bush, John [Battelle

    2010-11-01

    The non-intrusive inspection (NII) of consolidated air cargo carried on commercial passenger aircraft continues to be a technically challenging, high-priority requirement of the Department of Homeland Security's Science and Technology Directorate (DHS S&T), the Transportation Security Agency and the Federal Aviation Administration. The goal of deploying a screening system that can reliably and cost-effectively detect explosive threats in consolidated cargo without adversely affecting the flow of commerce will require significant technical advances that will take years to develop. To address this critical National Security need, the Battelle Memorial Institute (Battelle), under a Cooperative Research and Development Agreement (CRADA) with four of its associated US Department of Energy (DOE) National Laboratories (Oak Ridge, Pacific Northwest, Idaho, and Brookhaven), conducted a research and development initiative focused on identifying, evaluating, and integrating technologies for screening consolidated air cargo for the presence of explosive threats. Battelle invested $8.5M of internal research and development funds during fiscal years 2007 through 2009. The primary results of this effort are described in this document and can be summarized as follows: (1) Completed a gap analysis that identified threat signatures and observables, candidate technologies for detection, their current state of development, and provided recommendations for improvements to meet air cargo screening requirements. (2) Defined a Commodity/Threat/Detection matrix that focuses modeling and experimental efforts, identifies technology gaps and game-changing opportunities, and provides a means of summarizing current and emerging capabilities. (3) Defined key properties (e.g., elemental composition, average density, effective atomic weight) for basic commodity and explosive benchmarks, developed virtual models of the physical distributions (pallets) of three commodity types and three

  5. Design of an intelligent monitoring microsystem for dangerous/fragile cargo transportation%危险/易损货物运输监测智能微系统设计

    Institute of Scientific and Technical Information of China (English)

    娄文忠; 郭明儒; 祖绍鹏

    2012-01-01

    针对当前物流行业发展需求及现有监测系统的不足,提出了一种新的危险/易损货物运输监测智能微系统.该系统采用信息管理分系统、数据交换分系统和状态监测分系统3层构架,分别实现信息管理、数据传输和状态监测等功能,形成了全程、多态、实时的货物监测网络.系统采用模块化设计,通过独立的微型模块执行感知、处理、传输和存储等功能,并可根据需求进行模块裁剪.系统充分采用MEMS技术成果,实现了小型化、低功耗.试运行结果表明,该系统可以对危险/易损货物的运输实施有效监控,有助于提高物流的安全性和信息化.%An intelligent micro-system system is designed to monitor the transportation of dangerous/ fragile goods. It is necessary to monitor the transportation of special goods such as toxic substances or fireworks, but the correlation systems or devices have some deficiencies in the functional integrity and application scope. A novel monitoring system is designed to solve this problem. The new system consists of information management subsystem, communication subsystem and monitoring subsystem. The information management subsystem includes a server and several clients. It manages the data of the system and provides query functions. The communication subsystem is mainly used to convert the communication protocols. The monitoring subsystem is the key of the whole system which performs the functions of monitoring, data processing and safety assessing. The three parts work together to form a powerful net that could realize real-time monitoring. The monitoring subsystem, which adapts modularization design, can be divided into several function modules such as controlling module, detecting module, communicating module, etc. These modules are connected by internal bus, so the monitoring subsystem is scalable to meet the requirements of different customers. The MEMS technology and achievements

  6. Ammonium Perchlorate Transportation Hazards Testing

    Science.gov (United States)

    1989-04-01

    n1 t- TI T1W- r- T’ T II 0 0L 10 T. J II )0 In L11 n n i) ) C, (71 T-. d n 𔃺 ’ O 4j ’G134j L) ) 0 4j .1-10. 0 Il I-I 60 In 0 InI ni ni nini r , - r...n Q TIT a tf M L) QtQ0 O 4 4 0.14 3 41,31)-1 17 �’tIl 014 l’ 01 i. 0 - a. OC t. L 0I n nI nini n0ni nu n- n-r- rd Ifl 0n - 44 4 0o 3-00- 300- -TI

  7. Boeing and EGAT Unveil World's First Large Cargo Freighter——Evergreen Aviation Technologies transforms Boeing747-400 for 787 Dreamliner cargo

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    @@ Evergreen Aviation Technologies Corporation (EGAT), a subsidiary of the Evergreen Group, and The Boeing Company unveiled the first of three Boeing 747-400 Large Cargo Freighters (LCF) modified to exacting specifications to transport giant-sized Boeing 787 "Dreamliner" assemblages.Boeing selected EGAT to perform the specialized aircraft conversions and work began in 2005. The three-aircraft conversion program will be completed in 2007.

  8. On the possibility of the in-cell molecular motors working as cargo moorings only

    CERN Document Server

    Lisowski, Bartosz

    2012-01-01

    Although active transport is considered the most efficient way of depositing materials in the appropriate compartments within living cells, free diffusion remains the energetically cheapest and most widespread determinant of the in-cell dynamics. Here we investigate the hypothesis of cargoes - vesicles or organelles - being transported by the means of free diffusion, limited spatially by the molecular motors. Routinely navigating through ever-changing and unsteady environment, utilizing chemical energy (e.g. from hydrolyzing ATP), as the result they transport cell's crucial components, such as neurotransmitters and organelles. In our model the motor, which we identify with kinesin-1 walking along the microtubule, tethers the cargo in the same manner as a mooring rope attached to a bollard holds a ship from drifting toward the open sea. We study the model behavior in the context of optical trap single molecule experiments, mimicking their procedures in our simulations and investigate how the mechanical propert...

  9. Functional architecture of the retromer cargo-recognition complex

    Science.gov (United States)

    Hierro, Aitor; Rojas, Adriana L.; Rojas, Raul; Murthy, Namita; Effantin, Grégory; Kajava, Andrey V.; Steven, Alasdair C.; Bonifacino, Juan S.; Hurley, James H.

    2008-01-01

    The retromer complex 1, 2 is required for the sorting of acid hydrolases to lysosomes 3-7, transcytosis of the polymeric Ig receptor 8, Wnt gradient formation 9, 10, iron transporter recycling 11, and processing of the amyloid precursor protein 12. Human retromer consists of two smaller complexes, the cargo recognition Vps26:Vps29:Vps35 heterotrimer, and a membrane-targeting heterodimer or homodimer of SNX1 and/or SNX2 13. The crystal structure of a Vps29:Vps35 subcomplex shows how the metallophosphoesterase-fold subunit Vps29 14, 15 acts as a scaffold for the C-terminal half of Vps35. Vps35 forms a horseshoe-shaped right-handed α-helical solenoid whose concave face completely covers the metal-binding site of Vps29 and whose convex face exposes a series of hydrophobic interhelical grooves. Electron microscopy shows that the intact Vps26:Vps29:Vps35 complex is a stick-shaped, somewhat flexible, structure, ∼ 21 nm long. A hybrid structural model derived from crystal structures, electron microscopy, interaction studies, and bioinformatics shows that the α-solenoid fold extends the full length of Vps35, and that Vps26 is bound at the opposite end from Vps29. This extended structure presents multiple binding sites for the SNX complex and receptor cargo, and appears capable of flexing to conform to curved vesicular membranes. PMID:17891154

  10. 78 FR 68784 - Cargo Securing Manuals

    Science.gov (United States)

    2013-11-15

    ... would authorize recognized classification societies or other approval authorities to review and approve.... The commenter said the NPRM did not adequately assess the economic impact of applying cargo securing... not calculate any regulatory economic impact on them. Seagoing barges in coastwise trade would not be...

  11. Cargo Integration Products for External Release

    Science.gov (United States)

    Sills, Joel W.

    2008-01-01

    This document consists of a listing of integration products by function: Reconfiguration Engineering, Payload Interface Requirements, and Cargo Integration Analysis. The products may be accessed from, the Flight Operation and Integration Office page, i.e. http://sspweb.jsc.nasa.gov/.

  12. 49 CFR 173.242 - Bulk packagings for certain medium hazard liquids and solids, including solids with dual hazards.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Bulk packagings for certain medium hazard liquids and solids, including solids with dual hazards. 173.242 Section 173.242 Transportation Other... medium hazard liquids and solids, including solids with dual hazards. When § 172.101 of this subchapter...

  13. Tracking 800-year-old Shipments: An Archaeological Investigation of the Mado Shipwreck Cargo, Taean, Korea

    Science.gov (United States)

    Kim, Minkoo; Moon, Whan Suk

    2011-12-01

    This paper examines cargo from an 800-year-old shipwreck and discusses its implications in relation to the exchange networks and maritime transportation of the Goryeo period (A.D. 918-1392) in Korea. In 2007, two local fishermen fortuitously discovered porcelain vessels from a Goryeo-period shipwreck off the mid-western coast of the Korean peninsula. Underwater excavation conducted by the National Research Institute of Maritime Cultural Heritage (NRIMCH) revealed that the ship was carrying a myriad of cargoes destined for Gaegyeong, the capital of the Goryeo dynasty. Excavation indicates that the main body of the cargo was porcelain vessels produced in the southern part of the peninsula. Archaeobotanical investigation of the wreck deposits revealed that the ship was carrying crops such as rice ( Oryza sativa L.), broomcorn millet ( Panicum miliaceum L.), foxtail millet ( Setaria italica (L.) P. Beauv.), and buckwheat ( Fagopyrum esculentum Moench) bound for the capital. Among the recovered objects were 73 wooden cargo tags with Chinese letters. These tags, equivalent to the modern day air bill, contained detailed information about the senders, recipients, and shipped goods. These findings indicate that during the Goryeo period maritime transportation played an important role in the interpersonal exchange of products over long distances.

  14. Assembly and Mechanical Properties of the Cargo-Free and Cargo-Loaded Bacterial Nanocompartment Encapsulin.

    Science.gov (United States)

    Snijder, Joost; Kononova, Olga; Barbu, Ioana M; Uetrecht, Charlotte; Rurup, W Frederik; Burnley, Rebecca J; Koay, Melissa S T; Cornelissen, Jeroen J L M; Roos, Wouter H; Barsegov, Valeri; Wuite, Gijs J L; Heck, Albert J R

    2016-08-08

    Prokaryotes mostly lack membranous compartments that are typical of eukaryotic cells, but instead, they have various protein-based organelles. These include bacterial microcompartments like the carboxysome and the virus-like nanocompartment encapsulin. Encapsulins have an adaptable mechanism for enzyme packaging, which makes it an attractive platform to carry a foreign protein cargo. Here we investigate the assembly pathways and mechanical properties of the cargo-free and cargo-loaded nanocompartments, using a combination of native mass spectrometry, atomic force microscopy and multiscale computational molecular modeling. We show that encapsulin dimers assemble into rigid single-enzyme bacterial containers. Moreover, we demonstrate that cargo encapsulation has a mechanical impact on the shell. The structural similarity of encapsulins to virus capsids is reflected in their mechanical properties. With these robust mechanical properties encapsulins provide a suitable platform for the development of nanotechnological applications.

  15. 46 CFR 154.310 - Cargo piping systems.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Cargo piping systems. 154.310 Section 154.310 Shipping... Arrangements § 154.310 Cargo piping systems. Cargo liquid or vapor piping must: (a) Be separated from other piping systems, except where an interconnection to inert gas or purge piping is required by §...

  16. 46 CFR 154.356 - Cargo emergency jettisoning piping.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Cargo emergency jettisoning piping. 154.356 Section 154.356 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES... Equipment Ship Arrangements § 154.356 Cargo emergency jettisoning piping. Emergency jettisoning piping...

  17. 46 CFR 154.1844 - Cargo tanks: Filling limits.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Cargo tanks: Filling limits. 154.1844 Section 154.1844... STANDARDS FOR SELF-PROPELLED VESSELS CARRYING BULK LIQUEFIED GASES Operations § 154.1844 Cargo tanks... cargo tank is not loaded: (1) More than 98 percent liquid full; or (2) In excess of the...

  18. 33 CFR 157.23 - Cargo and ballast system information.

    Science.gov (United States)

    2010-07-01

    ... CARRYING OIL IN BULK Design, Equipment, and Installation § 157.23 Cargo and ballast system information. (a... automatic and manual operation of the cargo and ballast system in the vessel. (b) The format and information... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Cargo and ballast system...

  19. 19 CFR 4.36 - Delayed discharge of cargo.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Delayed discharge of cargo. 4.36 Section 4.36... TREASURY VESSELS IN FOREIGN AND DOMESTIC TRADES Landing and Delivery of Cargo § 4.36 Delayed discharge of cargo. (a) When pursuant to section 457, Tariff Act of 1930, customs officers are placed on a...

  20. 46 CFR 98.25-80 - Cargo hose.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Cargo hose. 98.25-80 Section 98.25-80 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CARGO AND MISCELLANEOUS VESSELS SPECIAL CONSTRUCTION, ARRANGEMENT, AND OTHER PROVISIONS FOR CERTAIN DANGEROUS CARGOES IN BULK Anhydrous Ammonia in Bulk §...

  1. 46 CFR 153.953 - Signals during cargo transfer.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Signals during cargo transfer. 153.953 Section 153.953 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES SHIPS... Procedures § 153.953 Signals during cargo transfer. The master shall ensure that: (a) The tankship displays a...

  2. 46 CFR 153.440 - Cargo temperature sensors.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Cargo temperature sensors. 153.440 Section 153.440 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES SHIPS... Temperature Control Systems § 153.440 Cargo temperature sensors. (a) Except as prescribed in paragraph (c) of...

  3. Interaction of railway and marine transport (Murmansk Transport Hub

    Directory of Open Access Journals (Sweden)

    Sokolov A.A.

    2015-03-01

    Full Text Available The classification of problems of interaction between water (marine and railway transport on the example of the Murmansk Transport Hub has been presented; some prospects for the development of technology for interaction with the logistics of transportation of general cargo in the Murmansk Commercial Seaport, Murmansk Marine Fishing Port, and oil terminals of the Kola Bay have been shown

  4. The complex network of global cargo ship movements

    CERN Document Server

    Kaluza, Pablo; Gastner, Michael T; Blasius, Bernd

    2010-01-01

    Transportation networks play a crucial role in human mobility, the exchange of goods, and the spread of invasive species. With 90% of world trade carried by sea, the global network of merchant ships provides one of the most important modes of transportation. Here we use information about the itineraries of 16,363 cargo ships during the year 2007 to construct a network of links between ports. We show that the network has several features which set it apart from other transportation networks. In particular, most ships can be classified in three categories: bulk dry carriers, container ships and oil tankers. These three categories do not only differ in the ships' physical characteristics, but also in their mobility patterns and networks. Container ships follow regularly repeating paths whereas bulk dry carriers and oil tankers move less predictably between ports. The network of all ship movements possesses a heavy-tailed distribution for the connectivity of ports and for the loads transported on the links with s...

  5. PINS Measurements of Explosive Simulants for Cargo Screening

    Energy Technology Data Exchange (ETDEWEB)

    E.H. Seabury

    2008-06-01

    As part of its efforts to prevent the introduction of explosive threats on commercial flights, the Transportation Security Administration (TSL) is evaluating new explosives detection systems (EDSs) for use in air cargo inspection. The TSL has contracted Battelle to develop a new type of explosives simulant to assist in this development. These are designed to mimic the elemental profile (C, H, N, O, etc.) of explosives as well as their densities. Several “neutron in—gamma out” (n,?) techniques have been considered to quantify the elemental profile in these new simulants and the respective explosives. The method chosen by Battelle is Portable Isotopic Neutron Spectroscopy (PINS), developed by Idaho National Laboratory (INL). Battelle wishes to validate that the simulants behave like the explosive threats with this technology. The results of the validation measurements are presented in this report.

  6. Discharging Part of LNG Liquid Cargo Handling Simulator

    Directory of Open Access Journals (Sweden)

    Zhen-Zhou Yang

    2013-09-01

    Full Text Available With the development of the national economy, it is important to develop LNG (Liquefied Natural Gas liquid cargo handling simulator. In this paper, the discharging part of Liquid Cargo Handling Simulator of LNG Carriers is developed by Visual Basic. The system includes 5 major forms and 3 mathematical models such as cargo pump model, the pressure and temperature model of the LNG vapour in the cargo tank and the liquid level model. The system can complete the unloading task. The system has become a preliminary model of LNG liquid cargo handlings simulator training.

  7. 14 CFR 437.29 - Hazard analysis.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Hazard analysis. 437.29 Section 437.29 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... Documentation § 437.29 Hazard analysis. (a) An applicant must perform a hazard analysis that complies with §...

  8. Aviation System Analysis Capability Air Carrier Investment Model-Cargo

    Science.gov (United States)

    Johnson, Jesse; Santmire, Tara

    1999-01-01

    The purpose of the Aviation System Analysis Capability (ASAC) Air Cargo Investment Model-Cargo (ACIMC), is to examine the economic effects of technology investment on the air cargo market, particularly the market for new cargo aircraft. To do so, we have built an econometrically based model designed to operate like the ACIM. Two main drivers account for virtually all of the demand: the growth rate of the Gross Domestic Product (GDP) and changes in the fare yield (which is a proxy of the price charged or fare). These differences arise from a combination of the nature of air cargo demand and the peculiarities of the air cargo market. The net effect of these two factors are that sales of new cargo aircraft are much less sensitive to either increases in GDP or changes in the costs of labor, capital, fuel, materials, and energy associated with the production of new cargo aircraft than the sales of new passenger aircraft. This in conjunction with the relatively small size of the cargo aircraft market means technology improvements to the cargo aircraft will do relatively very little to spur increased sales of new cargo aircraft.

  9. Scheduling vehicles in automated transportation systems : algorithms and case study

    NARCIS (Netherlands)

    Heijden, van der Matthieu; Ebben, Mark; Gademann, Noud; Harten, van Aart

    2000-01-01

    One of the major planning issues in large scale automated transportation systems is so-called empty vehicle management, the timely supply of vehicles to terminals in order to reduce cargo waiting times. Motivated by a Dutch pilot project on an underground cargo transportation system using Automated

  10. Cargo adaptors: structures illuminate mechanisms regulating vesicle biogenesis.

    Science.gov (United States)

    Paczkowski, Jon E; Richardson, Brian C; Fromme, J Christopher

    2015-07-01

    Cargo adaptors sort transmembrane protein cargos into nascent vesicles by binding directly to their cytosolic domains. Recent studies have revealed previously unappreciated roles for cargo adaptors and regulatory mechanisms governing their function. The adaptor protein (AP)-1 and AP-2 clathrin adaptors switch between open and closed conformations that ensure they function at the right place at the right time. The exomer cargo adaptor has a direct role in remodeling the membrane for vesicle fission. Several different cargo adaptors functioning in distinct trafficking pathways at the Golgi are similarly regulated through bivalent binding to the ADP-ribosylation factor 1 (Arf1) GTPase, potentially enabling regulation by a threshold concentration of Arf1. Taken together, these studies highlight that cargo adaptors do more than just adapt cargos.

  11. The Status and Investigation on Highway Transportation Safety Management of Hazardous Materials%危险品公路运输安全管理现状及探究

    Institute of Scientific and Technical Information of China (English)

    严虎

    2011-01-01

    This paper reveals the severe situation of highway transportation security by the characters of hazardous transport accidents.The problems in domestic road transport safety management were discussed by analyzing the datum of traffic accidents.Some suggestions on road management regulations were put forward based on the research results of road safety and the road management methods in western developed countries.%本文从了解危险品交通事故的特性出发,揭示了严峻的道路运输安全形势。通过事故数据分析,剖析了我国道路交通管理的弊端。结合道路安全领域的研究以及西方发达国家道路管理模式,对我国道路管理制度提出一些建议。

  12. A Review of Cargo Handling Equipment

    Science.gov (United States)

    1971-10-01

    surge, and sway). If, for example, only heave compensation is employed, i.e., one constraint, then the cargo may swing in a pendulous manner and the...pendulous mass as well as lack of heave compensation . One proposed method for overcoming the heave compensation problem is to tie the helicopter to the...deck. Further, any method which does not use the ship as a reference (i.e., not mounted on the ship) must also provide for some type of heave

  13. 基于三维视角的危险品运输风险管理机制研究%Management Mechanism of Transport Risk for Hazardous Materials Based on Three-Dimensional Viewpoints

    Institute of Scientific and Technical Information of China (English)

    孙彦明; 赵鲁华; 周勇

    2015-01-01

    优化危险品运输风险管理机制,能够降低运输风险,同时兼顾企业成本需求,为政府决策提供参考。通过对我国近些年发生的诸多危险品运输事故进行调查研究,分析了危险品运输应急预案和风险应对方面存在的薄弱问题,同时基于系统论的研究方法,构建了三维分析视角的风险分析逻辑架构。基于风险管理的主体、客体及过程三个维度,通过对危险品运输风险因素的全面分析,进行运输风险的危害性分析以及风险事件与诱因之间的关联性评估,最后提出风险危害削减和控制的应对措施:建立全方位的监管责任制度,确保“有人管理”;健全全面的风险信息反馈机制,确保“管理全面”;通过路径优化和HACCP (Hazard Analysis Critical Control Point,危害分析的临界控制点)控制方法,从源头开始,实现危险品运输“全程可控”。研究指出:三维视角下的风险识别、风险评估和风险应对构成一个相互联系、相互作用的系统,形成全面的风险管理机制。%The optimization of risk management mechanism of hazardous materials transportation can reduce the transportation risk and meanwhile take into account the cost of enterprise, which provides ref⁃erences for the government decision.By investigating lots of traffic accidents of transportation for hazard⁃ous materials in recent years, the problems in emergency plan and risk response were analyzed. Based on systematic research method, the logical framework on risk analysis of the three-dimensional perspec⁃tive was built. According to the subject, object and process of risk management, some risk factors of haz⁃ardous materials transportation were comprehensively analyzed. Then, hazard analysis on transportation risk was put forward and relevance between risk events and its causes was evaluated. Finally, measures on reduction and controlling of risks were

  14. 14 CFR 437.55 - Hazard analysis.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Hazard analysis. 437.55 Section 437.55 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING EXPERIMENTAL PERMITS Safety Requirements § 437.55 Hazard analysis. (a) A permittee...

  15. 14 CFR 417.413 - Hazard areas.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Hazard areas. 417.413 Section 417.413 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LAUNCH SAFETY Ground Safety § 417.413 Hazard areas. (a) General. A launch operator...

  16. High Power Nuclear Electric Propulsion (NEP) for Cargo and Propellant Transfer Missions in Cislunar Space

    Science.gov (United States)

    Falck, Robert D.; Borowski, Stanley K.

    2003-01-01

    The performance of Nuclear Electric Propulsion (NEP) in transporting cargo and propellant from Low Earth Orbit (LEO) to the first Earth-Moon Lagrange point (EML1) is examined. The baseline NEP vehicle utilizes a fission reactor system with Brayton power conversion for electric power generation to power multiple liquid hydrogen magnetoplasmadynamic (MPD) thrusters. Vehicle characteristics and performance levels are based on technology availability in a fifteen to twenty year timeframe. Results of numerical trajectory analyses are also provided.

  17. 美军军用危险品空运的特点及启示%Traits of US Army in Military Hazardous Articles Transportation by Aviation and Its Enlightenment

    Institute of Scientific and Technical Information of China (English)

    周柯雯; 聂志强; 海军

    2011-01-01

    军用危险品种类繁多,理化性质复杂,是平战时军事运输的重要品类。通过对美军军用危险品航空运输工作的研究,总结其特点及成功经验,提出做好我军军用危险品空运工作的几点启示。%As the important category of military conveyance in peacetime and wartime,military hazardous articles have a great variety, the physics and chemistry property is complicated. Through the research of military hazardous articles transportation by aviation a

  18. [Environmental, social, and roadway vulnerability in accidents involving transportation of hazardous products: a case study of the BR-101 highway between Osório and Torres in Rio Grande do Sul State, Brazil].

    Science.gov (United States)

    Tinoco, Maria Auxiliadora Cannarozzo; Nodari, Christine Tessele; Pereira, Kimberllyn Rosa da Silva

    2016-09-19

    This study aimed to assess the environmental and social vulnerability and identify critical highway stretches for accidents involving transportation of hazardous products on the BR-101 highway between the cities of Osório and Torres in Rio Grande do Sul State, Brazil. The study's approach consisted of a multiple-criteria analysis combining highway safety analysis and environmental and social vulnerability analysis in the occurrence of accidents with hazardous products, plus cartographic analysis techniques. Thirty-eight kilometers of the highway showed high vulnerability, of which 8 kilometers with critical vulnerability, associated with bridges over rivers, water uptake points, a tunnel, environmental preservation areas, and an urban area. These stretches should be prioritized when developing action plans for accident mitigation and development of public policies for this highway. This proved to be an unprecedented approach when compared to existing studies and a potentially useful tool for decision-making in emergency operations.

  19. Intracellular Delivery of Molecular Cargo Using Cell-Penetrating Peptides and the Combination Strategies

    Directory of Open Access Journals (Sweden)

    Hua Li

    2015-08-01

    Full Text Available Cell-penetrating peptides (CPPs can cross cellular membranes in a non-toxic fashion, improving the intracellular delivery of various molecular cargos such as nanoparticles, small molecules and plasmid DNA. Because CPPs provide a safe, efficient, and non-invasive mode of transport for various cargos into cells, they have been developed as vectors for the delivery of genetic and biologic products in recent years. Most common CPPs are positively charged peptides. While delivering negatively charged molecules (e.g., nucleic acids to target cells, the internalization efficiency of CPPs is reduced and inhibited because the cationic charges on the CPPs are neutralized through the covering of CPPs by cargos on the structure. Even under these circumstances, the CPPs can still be non-covalently complexed with the negatively charged molecules. To address this issue, combination strategies of CPPs with other typical carriers provide a promising and novel delivery system. This review summarizes the latest research work in using CPPs combined with molecular cargos including liposomes, polymers, cationic peptides, nanoparticles, adeno-associated virus (AAV and calcium for the delivery of genetic products, especially for small interfering RNA (siRNA. This combination strategy remedies the reduced internalization efficiency caused by neutralization.

  20. Hazardous Chemicals

    Centers for Disease Control (CDC) Podcasts

    2007-04-10

    Chemicals are a part of our daily lives, providing many products and modern conveniences. With more than three decades of experience, The Centers for Disease Control and Prevention (CDC) has been in the forefront of efforts to protect and assess people's exposure to environmental and hazardous chemicals. This report provides information about hazardous chemicals and useful tips on how to protect you and your family from harmful exposure.  Created: 4/10/2007 by CDC National Center for Environmental Health.   Date Released: 4/13/2007.

  1. ATHLETE: a Cargo and Habitat Transporter for the Moon

    Science.gov (United States)

    Wilcox, Brian H.

    2009-01-01

    As part of the NASA Exploration Technology Development Program, the Jet Propulsion Laboratory is developing a vehicle called ATHLETE: the All-Terrain Hex-Limbed Extra-Terrestrial Explorer. The vehicle concept is based on six wheels at the ends of six multi-degree-of-freedom limbs. Because each limb has enough degrees of freedom for use as a general-purpose leg, the wheels can be locked and used as feet to walk out of excessively soft or other extreme terrain. Since the vehicle has this alternative mode of traversing through (or at least out of) extreme terrain, the wheels and wheel actuators can be sized only for nominal terrain. There are substantial mass savings in the wheels and wheel actuators associated with designing for nominal instead of extreme terrain. These mass savings are comparable-to or larger-than the extra mass associated with the articulated limbs. As a result, the entire mobility system, including wheels and limbs, can be about 25 percent lighter than a conventional mobility chassis for planetary exploration. A side benefit of this approach is that each limb has sufficient degrees-of-freedom for use as a general-purpose manipulator (hence the name "limb" instead of "leg"). Our prototype ATHLETE vehicles have quick-disconnect tool adapters on the limbs that allow tools to be drawn out of a "tool belt" and maneuvered by the limb. A rotating power-take-off from the wheel actuates the tools, so that they can take advantage of the 1-plus-horsepower motor in each wheel to enable drilling, gripping or other power-tool functions.

  2. 76 FR 6178 - Deadline for Notification of Intent to Use the Airport Improvement Program (AIP) Primary, Cargo...

    Science.gov (United States)

    2011-02-03

    ... [Federal Register Volume 76, Number 23 (Thursday, February 3, 2011)] [Notices] [Page 6178] [FR Doc No: 2011-2381] DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Deadline for Notification of Intent to Use the Airport Improvement Program (AIP) Primary, Cargo, and Nonprimary...

  3. Collective motor dynamics in membrane transport in vitro

    NARCIS (Netherlands)

    Shaklee, Paige Marie

    2009-01-01

    Key cellular processes such as cell division, internal cellular organization, membrane compartmentalization and intracellular transport rely on motor proteins. Motor proteins, ATP-based mechanoenzymes, actively transport cargo throughout the cell by walking on cytoskeletal filaments. Motors have bee

  4. APPROACH TO BUILDING A MODEL OF THE FUNCTIONING TRANSPORT PROCESS IN INTERNATIONAL TRAFFIC

    Directory of Open Access Journals (Sweden)

    P. Gorbachev

    2015-12-01

    Full Text Available The mathematical model to determine the profit of trucking companies, which takes into account the probabilistic properties of transport process elements when performing single orders in international cargo transportation is prognosed. The proposed criterion makes it possible to obtain a probabilistic assessment of trip results in both directions and choosing the most effective directions of cargo transportation.

  5. Estimation of the acute inhalation hazards of chemicals based on route-to-route and local endpoint extrapolation: Experience from Bulk Maritime Transport

    NARCIS (Netherlands)

    Höfer, T.; James, D.; Syversen, T.; Bowmer, T.

    2011-01-01

    Data on acute lethal inhalation toxicity from animal studies are commonly required for assessing the hazards to human health of volatile, gaseous and dusty chemicals or their mixtures. The International Maritime Organisation (IMO) made the provision of acute inhalation toxicity data a mandatory

  6. Estimation of the acute inhalation hazards of chemicals based on route-to-route and local endpoint extrapolation: Experience from Bulk Maritime Transport

    NARCIS (Netherlands)

    Höfer, T.; James, D.; Syversen, T.; Bowmer, T.

    2011-01-01

    Data on acute lethal inhalation toxicity from animal studies are commonly required for assessing the hazards to human health of volatile, gaseous and dusty chemicals or their mixtures. The International Maritime Organisation (IMO) made the provision of acute inhalation toxicity data a mandatory requ

  7. Identification of Cargo for Adaptor Protein (AP) Complexes 3 and 4 by Sucrose Gradient Profiling.

    Science.gov (United States)

    Pertl-Obermeyer, Heidi; Wu, Xu Na; Schrodt, Jens; Müdsam, Christina; Obermeyer, Gerhard; Schulze, Waltraud X

    2016-09-01

    Intracellular vesicle trafficking is a fundamental process in eukaryotic cells. It enables cellular polarity and exchange of proteins between subcellular compartments such as the plasma membrane or the vacuole. Adaptor protein complexes participate in the vesicle formation by specific selection of the transported cargo. We investigated the role of the adaptor protein complex 3 (AP-3) and adaptor protein complex 4 (AP-4) in this selection process by screening for AP-3 and AP-4 dependent cargo proteins. Specific cargo proteins are expected to be mis-targeted in knock-out mutants of adaptor protein complex components. Thus, we screened for altered distribution profiles across a density gradient of membrane proteins in wild type versus ap-3β and ap-4β knock-out mutants. In ap-3β mutants, especially proteins with transport functions, such as aquaporins and plasma membrane ATPase, as well as vesicle trafficking proteins showed differential protein distribution profiles across the density gradient. In the ap-4β mutant aquaporins but also proteins from lipid metabolism were differentially distributed. These proteins also showed differential phosphorylation patterns in ap-3β and ap-4β compared with wild type. Other proteins, such as receptor kinases were depleted from the AP-3 mutant membrane system, possibly because of degradation after mis-targeting. In AP-4 mutants, membrane fractions were depleted for cytochrome P450 proteins, cell wall proteins and receptor kinases. Analysis of water transport capacity in wild type and mutant mesophyll cells confirmed aquaporins as cargo proteins of AP-3 and AP-4. The combination of organelle density gradients with proteome analysis turned out as a suitable experimental strategy for large-scale analyses of protein trafficking.

  8. ASH1 mRNP-core factors form stable complexes in absence of cargo RNA at physiological conditions.

    Science.gov (United States)

    Edelmann, Franziska T; Niedner, Annika; Niessing, Dierk

    2015-01-01

    Asymmetric ASH1 mRNA transport during mitosis of budding yeast constitutes one of the best-studied examples of mRNA localization. Recently, 2 studies used in vitro motility assays to prove that motile ASH1 mRNA-transport complexes can be reconstituted entirely from recombinant factors. Both studies, however, differed in their conclusions on whether cargo RNA itself is required for particle assembly and thus activation of directional transport. Here we provide direct evidence that stable complexes do assemble in absence of RNA at physiologic conditions and even at ionic strengths above cellular levels. These results directly confirm the previous notion that the ASH1 transport machinery is not activated by the cargo RNA itself, but rather through protein-protein interactions.

  9. Installation of the Canadian Muon Cargo Inspection System at CRL

    Science.gov (United States)

    2014-04-01

    Installation of the Canadian Muon Cargo Inspection System at CRL Prepared by: Guy Jonkmans Atomic Energy of Canada Limited Chalk River ON...INSTALLATION OF THE CANADIAN MUON CARGO INSPECTION SYSTEM AT CRL 153-30100-REPT-001 Revision 0 2013/02/19 UNRESTRICTED 2013/02/19 ILLIMITÉ 153...30100-REPT-001 2013/02/19 Report, General Installation of the Canadian Muon Cargo Inspection System at CRL Research and Development 153-30100

  10. Column generation approaches to ship scheduling with flexible cargo sizes

    DEFF Research Database (Denmark)

    Brønmo, Geir; Nygreen, Bjørn; Lysgaard, Jens

    2010-01-01

    We present a Dantzig-Wolfe procedure for the ship scheduling problem with flexible cargo sizes. This problem is similar to the well-known pickup and delivery problem with time windows, but the cargo sizes are defined by intervals instead of by fixed values. The flexible cargo sizes have...... consequences for the times used in the ports because both the loading and unloading times depend on the cargo sizes. We found it computationally hard to find exact solutions to the subproblems, so our method does not guarantee to find the optimum over all solutions. To be able to say something about how good...

  11. Path Selection for Road Transport of Hazardous Chemicals with Time Window Constraint%带时间窗约束的道路危险品运输路径选择研究

    Institute of Scientific and Technical Information of China (English)

    夏超

    2014-01-01

    对已有危险品运输模型进行分析,针对当前危险品类物流配送网络的特点,提出了在时间窗约束条件下城市道路网络中的危险品配送模型,该模型以整个网络中事故发生的期望和影响人数最小为目标。设计了目标集成方法和对集成后目标函数求解的扩展标号法来计算该多目标问题的Pareto最优折衷解,最后用实例对算法进行了验证。%Through the analysis of existing transport models for hazardous chemicals, according to the char-acteristics of the current distribution network for hazardous category logistics, this paper puts forward the distri-bution model with time window constraints for hazardous goods in urban road network, with the expectations of the least accident occurrence in the network and the minimum number of people affected as the target. The target integration and label propagation method for solving the integrated objective function is designed to calculate the multi-objective problem of Pareto optimal compromise solution. Finally, the algorithm is verified with a practical example.

  12. 46 CFR 308.517 - Open Cargo Policy, Form MA-300.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Open Cargo Policy, Form MA-300. 308.517 Section 308.517... Risk Cargo Insurance Ii-Open Policy War Risk Cargo Insurance § 308.517 Open Cargo Policy, Form MA-300. The standard form of War Risk Open Cargo, Form MA-300, may be obtained from the American War...

  13. 46 CFR 150.160 - Carrying a cargo as an exception to the compatibility chart.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Carrying a cargo as an exception to the compatibility... BULK DANGEROUS CARGOES COMPATIBILITY OF CARGOES § 150.160 Carrying a cargo as an exception to the compatibility chart. The Operator of a vessel having on board a cargo carried as an exception under §...

  14. Study on Highway Service Area Classification by Safety of Hazardous Chemicals Transportation%基于危化品运输安全的服务区分类

    Institute of Scientific and Technical Information of China (English)

    潘玲; 刘万能; 朱锐

    2014-01-01

    From a security perspective,according to the demand characteristics of hazardous chemical vehicles and the overall functionalities of highway service areas,the principles,influencing factors and its assignment cri-teria of service area classification are determined.The service areas are divided into three categories,namely Category A for hazardous chemical vehicles parking,category B only offering hazardous chemical vehicles water or oil and category C is prohibited for hazardous chemical vehicles driving into.The cluster analysis method is used to divide the pilot service areas into similar class,and the parking saturation level is used for determining the type properties of various types of service areas.%从安全性角度出发,根据危化品运输车辆的需求特性、服务区整体功能性,确定服务区划分的原则、影响因素及其赋值标准,将服务区划分为三大类,分别为 A 类可供危化品车辆停放的服务区,B 类仅提供加油加水的服务区和 C 类禁止危化品车辆驶入的服务区。并运用聚类分析方法将试点服务区划分相似的类,最后通过停车饱和度指标的高低判定各类服务区的类型属性。

  15. Reliability analysis of the bulk cargo loading system including dependent components

    Science.gov (United States)

    Blokus-Roszkowska, Agnieszka

    2016-06-01

    In the paper an innovative approach to the reliability analysis of multistate series-parallel systems assuming their components' dependency is presented. The reliability function of a multistate series system with components dependent according to the local load sharing rule is determined. Linking these results for series systems with results for parallel systems with independent components, we obtain the reliability function of a multistate series-parallel system assuming dependence of components' departures from the reliability states subsets in series subsystem and assuming independence between these subsystems. As a particular case, the reliability function of a multistate series-parallel system composed of dependent components having exponential reliability functions is fixed. Theoretical results are applied practically to the reliability evaluation of a bulk cargo transportation system, which main area is to load bulk cargo on board the ships. The reliability function and other reliability characteristics of the loading system are determined in case its components have exponential reliability functions with interdependent departures rates from the subsets of their reliability states. Finally, the obtained results are compared with results for the bulk cargo transportation system composed of independent components.

  16. ATHLETE: A Cargo-Handling Vehicle for Solar System Exploration

    Science.gov (United States)

    Wilcox, Brian H.

    2011-01-01

    As part of the NASA Exploration Technology Development Program, the Jet Propulsion Laboratory is developing a vehicle called ATHLETE: the All-Terrain Hex-Limbed Extra-Terrestrial Explorer. Each vehicle is based on six wheels at the ends of six multi-degree-of-freedom limbs. Because each limb has enough degrees of freedom for use as a general-purpose leg, the wheels can be locked and used as feet to walk out of excessively soft or other extreme terrain. Since the vehicle has this alternative mode of traversing through or at least out of extreme terrain, the wheels and wheel actuators can be sized for nominal terrain. There are substantial mass savings in the wheel and wheel actuators associated with designing for nominal instead of extreme terrain. These mass savings are comparable-to or larger-than the extra mass associated with the articulated limbs. As a result, the entire mobility system, including wheels and limbs, can be about 25% lighter than a conventional mobility chassis. A side benefit of this approach is that each limb has sufficient degrees-of-freedom to use as a general-purpose manipulator (hence the name "limb" instead of "leg"). Our prototype ATHLETE vehicles have quick-disconnect tool adapters on the limbs that allow tools to be drawn out of a "tool belt" and maneuvered by the limb. A power-take-off from the wheel actuates the tools, so that they can take advantage of the 1+ horsepower motor in each wheel to enable drilling, gripping or other power-tool functions. Architectural studies have indicated that one useful role for ATHLETE in planetary (moon or Mars) exploration is to "walk" cargo off the payload deck of a lander and transport it across the surface. Recent architectural approaches are focused on the concept that the lander descent stage will use liquid hydrogen as a propellant. This is the highest performance chemical fuel, but it requires very large tanks. A natural geometry for the lander is to have a single throttleable rocket engine on

  17. Fire safety of LPG in marine transportation

    Energy Technology Data Exchange (ETDEWEB)

    Martinsen, W.E.; Johnson, D.W.; Welker, J.R.

    1980-08-01

    This report contains an analytical examination of cargo spill and fire hazard potential associated with the marine handling of liquefied petroleum gas (LPG) as cargo. Principal emphasis was on cargo transfer operations for ships unloading at receiving terminals, and barges loading or unloading at a terminal. Major safety systems, including emergency shutdown systems, hazard detection systems, and fire extinguishment and control systems were included in the analysis. Spill probabilities were obtained from fault tree analyses utilizing composite LPG tank ship and barge designs. Failure rates for hardware in the analyses were generally taken from historical data on similar generic classes of hardware, there being very little historical data on the specific items involved. Potential consequences of cargo spills of various sizes are discussed and compared to actual LPG vapor cloud incidents. The usefulness of hazard mitigation systems (particularly dry chemical fire extinguishers and water spray systems) in controlling the hazards posed by LPG spills and spill fires is also discussed. The analysis estimates the probability of fatality for a terminal operator is about 10/sup -6/ to 10/sup -5/ per cargo transfer operation. The probability of fatality for the general public is substantially less.

  18. Avaliação de transportadoras de materiais perigosos utilizando o método electre tri The eletre tri method applied to the evaluation of companies transporting hazardous materials

    Directory of Open Access Journals (Sweden)

    Helder Gomes Costa

    2004-08-01

    Full Text Available Neste trabalho apresenta-se uma metodologia para a classificação e escolha de prestadores de serviço para transporte de materiais perigosos, fundamentado na metodologia de Auxílio Multicritério à Decisão - AMD. A metodologia aqui proposta apresenta características que permitem considerar a subjetividade inerente ao processo de avaliação de desempenho dos Prestadores de Serviço, diferenciando-se, assim, de outros métodos de seleção de fornecedores de serviços de transportes. As particularidades da metodologia proposta, principalmente em relação à sua aplicabilidade, foram verificadas num caso em uma empresa distribuidora de combustíveis, com rede de postos em todo o Brasil.This article proposes a method for the classification and selection of hazardous materials transporters based on Multicriteria Decision Making (MCDM concepts. This approach involves characteristics that allow the subjectivity inherent to the process of evaluating the performance of Service Companies to be considered, thus differentiating it from other transport services supplier selection methods. The particularities of the proposed methodology, particularly insofar as its applicability is concerned, were assessed by means of a case study involving a fuel distribution company which owns gas stations throughout the country.

  19. Mathematical model with spatially uniform regulation explains long-range bidirectional transport of early endosomes in fungal hyphae.

    Science.gov (United States)

    Gou, Jia; Edelstein-Keshet, Leah; Allard, Jun

    2014-08-15

    In many cellular contexts, cargo is transported bidirectionally along microtubule bundles by dynein and kinesin-family motors. Upstream factors influence how individual cargoes are locally regulated, as well as how long-range transport is regulated at the whole-cell scale. Although the details of local, single-cargo bidirectional switching have been extensively studied, it remains to be elucidated how this results in cell-scale spatial organization. Here we develop a mathematical model of early endosome transport in Ustilago maydis. We demonstrate that spatiotemporally uniform regulation, with constant transition rates, results in cargo dynamics that is consistent with experimental data, including data from motor mutants. We find that microtubule arrays can be symmetric in plus-end distribution but asymmetric in binding-site distribution in a manner that affects cargo dynamics and that cargo can travel past microtubule ends in microtubule bundles. Our model makes several testable predictions, including secondary features of dynein and cargo distributions.

  20. 46 CFR 98.25-55 - Cargo piping.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Cargo piping. 98.25-55 Section 98.25-55 Shipping COAST... Cargo piping. (a) Piping shall be of seamless steel meeting the requirements of § 56.60-1 of subchapter F (Marine Engineering) of this chapter. The piping shall be of not less than Schedule 40...

  1. 46 CFR 30.10-5 - Cargo-TB/ALL.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Cargo-TB/ALL. 30.10-5 Section 30.10-5 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS GENERAL PROVISIONS Definitions § 30.10-5 Cargo—TB/ALL. The term cargo means combustible liquid, flammable liquid, or liquefied flammable gas unless...

  2. 29 CFR 1917.14 - Stacking of cargo and pallets.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 7 2010-07-01 2010-07-01 false Stacking of cargo and pallets. 1917.14 Section 1917.14 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION... pallets. Cargo, pallets and other material stored in tiers shall be stacked in such a manner as to provide...

  3. 49 CFR 180.405 - Qualification of cargo tanks.

    Science.gov (United States)

    2010-10-01

    ... protection or other appropriate accident damage protection device. (v) A cargo tank may be constructed of.... (l) MC 300, MC 301, MC 302, MC 303, MC 305, MC 306 cargo tank—Rear accident damage protection. (1... accident damage protection device to protect the tank and piping in the event of a rear-end collision...

  4. 75 FR 35318 - Cargo Insurance for Property Loss or Damage

    Science.gov (United States)

    2010-06-22

    ... cargo insurance with FMCSA is essential to prevent fraud. The commenter stated that many instances of insurance fraud have been thwarted by having an independent government source for checking carrier insurance... Federal Motor Carrier Safety Administration 49 CFR Parts 365 and 387 RIN 2126-AB21 Cargo Insurance for...

  5. Information tecnology and its impact on port cargo distribution businness

    OpenAIRE

    Trampus, Francesca

    2002-01-01

    The IT revolution has dynamised the port cargo business: up-to-date software is needed to optimize operations such as vessel loading, yard planning, equipment flow, gate handling, administration and invoicing and it is also essential for vessel tracking, electronic declaration of cargo and passengers and as a communication platform to all port users.

  6. 46 CFR 151.20-10 - Cargo system instrumentation.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Cargo system instrumentation. 151.20-10 Section 151.20-10 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES... instrumentation. (a) Each tank operated at other than ambient temperature shall be provided with at least...

  7. 46 CFR 154.195 - Aluminum cargo tank: Steel enclosure.

    Science.gov (United States)

    2010-10-01

    ... published in “Rules for Building and Classing Steel Vessels”, 1981. (c) The steel cover for the aluminum... 46 Shipping 5 2010-10-01 2010-10-01 false Aluminum cargo tank: Steel enclosure. 154.195 Section... CARGOES SAFETY STANDARDS FOR SELF-PROPELLED VESSELS CARRYING BULK LIQUEFIED GASES Design, Construction...

  8. 46 CFR 154.548 - Cargo piping: Flow capacity.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Cargo piping: Flow capacity. 154.548 Section 154.548... and Process Piping Systems § 154.548 Cargo piping: Flow capacity. Piping with an excess flow valve must have a vapor or liquid flow capacity that is greater than the rated closing flow under § 154.546....

  9. 46 CFR 154.1850 - Entering cargo handling spaces.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Entering cargo handling spaces. 154.1850 Section 154... cargo handling spaces. (a) The master shall ensure that the ventilation system under § 154.1200 is in... handling equipment. (b) The master shall ensure that a warning sign listing the requirement for use of the...

  10. Study on GIS-based visual management system of urban hazardous materials transportation%基于GIS的城区危险品运输可视化管控系统研究

    Institute of Scientific and Technical Information of China (English)

    王洪德; 孟祥妹

    2012-01-01

    通过对城区危险品运输管理现状的分析,针对城区危险品道路运输监管过程中存在的沟通信息不畅、权责不明等实际情况,融合城区公共安全联动机制的系统设计理念,基于GIS技术开发了由路径分析选择、应急救援管理、危险货物管理、危险源管理、车辆管理、信息显示及查询、地理信息和系统总控等模块构成的城区道路危险品运输可视化管控系统.首先,基于需求分析及开发目的,给出了系统总体结构框架,阐述了各模块的实施过程及效果;然后,建立了由空间数据与属性数据构成的GIS数据库,并将运输风险最小、费用最低作为路径优化的选线标准;最后,基于角改进的Dijsktra算法,实现系统路径的分析与选择.%The present paper attempts to study and solve the problems of information gaps and the liabilities in processing the urban hazardous material transportation supervision based on the analysis of the urban hazardous material transportation management and control situation and the urban public security interactive communication system design. For this purpose, we have developed a GIS-based visual management and control system consisting of eight parts, that is, the route analysis and choice, the emergency rescue management, the hazardous material management, the major hazard installations, the vehicle management, the information enquiry and delivery, the geographical information management, and the control module of the information control system. According to our system, while in operation , the general information control system, first of all, turns on and enacts all the implementation procedures, bringing all the modules into operation. Secondly, we have established a database of GIS, which includes the space data and the attributive data choice device so as to take measures to minimize the transportation risk and reduce transportation cost to the least, in so doing to display the

  11. RISK MANAGEMENT AS TRANSPORTATION SAFETY PROVISION INSTRUMENT IN RUSSIA

    Directory of Open Access Journals (Sweden)

    V. A. Nikolayev

    2012-01-01

    Full Text Available Safety of transportation in Russia is subject to a variety of threats. Discussed in the article are characteristics of major threats to transportation security. State transportation policy directions that make it possible to ensure the security of cargo and passenger transportation are shown. A listof activities and innovative risk management tools that provide for improved safety of railway transportation is proposed.

  12. 46 CFR 150.130 - Loading a cargo on vessels carrying cargoes with which it is incompatible.

    Science.gov (United States)

    2010-10-01

    ... it is incompatible. 150.130 Section 150.130 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY... carrying cargoes with which it is incompatible. Except as described in § 150.160, the person in charge of a... any cargo in table I with which it is incompatible by two barriers such as formed by a: (1)...

  13. 22 CFR 228.21 - Ocean transportation.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Ocean transportation. 228.21 Section 228.21... for USAID Financing § 228.21 Ocean transportation. (a) The Cargo Preference Act of 1954, Section 901(b... transportation services is determined by the flag registry of the vessel. (1) When the authorized source...

  14. Electrostatic hazards

    CERN Document Server

    Luttgens, Günter; Luttgens, Gnter; Luttgens, G Nter

    1997-01-01

    In the US, UK and Europe there is in excess of one notifiable dust or electrostatic explosion every day of the year. This clearly makes the hazards associated with the handling of materials subject to either cause or react to electrostatic discharge of vital importance to anyone associated with their handling or industrial bulk use. This book provides a comprehensive guide to the dangers of static electricity and how to avoid them. It will prove invaluable to safety managers and professionals, as well as all personnel involved in the activities concerned, in the chemical, agricultural, pharmaceutical and petrochemical process industries. The book makes extended use of case studies to illustrate the principles being expounded, thereby making it far more open, accessible and attractive to the practitioner in industry than the highly theoretical texts which are also available. The authors have many years' experience in the area behind them, including the professional teaching of the content provided here. Günte...

  15. Scheduling vehicles in automated transportation systems Algorithms and case study: Algorithms and case study

    NARCIS (Netherlands)

    Heijden, van der Matthieu; Ebben, Mark; Gademann, Noud; Harten, van Aart

    2002-01-01

    One of the major planning issues in large scale automated transportation systems is so-called empty vehicle management, the timely supply of vehicles to terminals in order to reduce cargo waiting times. Motivated by a Dutch pilot project on an underground cargo transportation system using Automated

  16. 77 FR 24885 - Hazardous Materials; Miscellaneous Amendments (RRR)

    Science.gov (United States)

    2012-04-26

    ... Dicarbonic Acid Diazide.'' Revise the Sec. 172.101 HMT to remove the entry for ``Zinc ethyl, see Diethylzinc... containers fitted into wheeled racks. Revise the requirements for cargo air transport of alcoholic beverages... Instructions (TI). Clarify the exceptions in Sec. 173.159a for non-spillable batteries secured to skids...

  17. 14 CFR 101.7 - Hazardous operations.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Hazardous operations. 101.7 Section 101.7 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR TRAFFIC... § 101.7 Hazardous operations. (a) No person may operate any moored balloon, kite, amateur rocket,...

  18. 14 CFR 103.9 - Hazardous operations.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Hazardous operations. 103.9 Section 103.9 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR TRAFFIC AND GENERAL OPERATING RULES ULTRALIGHT VEHICLES Operating Rules § 103.9 Hazardous operations. (a)...

  19. Biological Activities of Extracellular Vesicles and Their Cargos from Bovine and Human Milk in Humans and Implications for Infants.

    Science.gov (United States)

    Zempleni, Janos; Aguilar-Lozano, Ana; Sadri, Mahrou; Sukreet, Sonal; Manca, Sonia; Wu, Di; Zhou, Fang; Mutai, Ezra

    2017-01-01

    Extracellular vesicles (EVs) in milk harbor a variety of compounds, including lipids, proteins, noncoding RNAs, and mRNAs. Among the various classes of EVs, exosomes are of particular interest, because cargo sorting in exosomes is a regulated, nonrandom process and exosomes play essential roles in cell-to-cell communication. Encapsulation in exosomes confers protection against enzymatic and nonenzymatic degradation of cargos and provides a pathway for cellular uptake of cargos by endocytosis of exosomes. Compelling evidence suggests that exosomes in bovine milk are transported by intestinal cells, vascular endothelial cells, and macrophages in human and rodent cell cultures, and bovine-milk exosomes are delivered to peripheral tissues in mice. Evidence also suggests that cargos in bovine-milk exosomes, in particular RNAs, are delivered to circulating immune cells in humans. Some microRNAs and mRNAs in bovine-milk exosomes may regulate the expression of human genes and be translated into protein, respectively. Some exosome cargos are quantitatively minor in the diet compared with endogenous synthesis. However, noncanonical pathways have been identified through which low concentrations of dietary microRNAs may alter gene expression, such as the accumulation of exosomes in the immune cell microenvironment and the binding of microRNAs to Toll-like receptors. Phenotypes observed in infant-feeding studies include higher Mental Developmental Index, Psychomotor Development Index, and Preschool Language Scale-3 scores in breastfed infants than in those fed various formulas. In mice, supplementation with plant-derived MIR-2911 improved the antiviral response compared with controls. Porcine-milk exosomes promote the proliferation of intestinal cells in mice. This article discusses the above-mentioned advances in research concerning milk exosomes and their cargos in human nutrition. Implications for infant nutrition are emphasized, where permitted, but data in infants are

  20. Simulation Analysis on Hazardous Materials Transportation Network Survivability Under Terrorist Attack%恐怖袭击下危险品运输网络抗毁性仿真分析

    Institute of Scientific and Technical Information of China (English)

    种鹏云; 帅斌

    2013-01-01

    Single node’s failure may cause cascading failure after hazardous materials transportation network is attacked by terrorist. Aiming at this problem, a model of cascading failure invulnerability for hazardous materials transportation network is established. Under the condition of the terrorist attack, it defines three kinds of node status which are“normal”,“failure”and“pause”, and from the perspective of“result”and“process”, the invulnerability indicators and their calculations are proposed. Then, it takes a quantificational research through different node degrees, different capacity coefficients and different planning modes by establishing simulation scene. The results show that the model is scientific and effective.%危险品运输网络在遭受恐怖袭击后单个节点的失效可能会引发网络级联失效现象。为解决该问题,构建一个危险品运输网络级联失效抗毁性模型。根据恐怖袭击条件,定义“正常”、“失效”和“暂停状态”3种节点状态,从“结果性”和“过程性”2个视角出发,提出网络抗毁性的评价测度。通过建立仿真场景,在不同节点的度、不同容量系数和不同规划方式下对危险品运输网络级联失效特性进行定量研究,结果证明了该级联失效抗毁性模型的科学有效性。

  1. Air cargo market outlook and impact via the NASA CLASS project. [Cargo/Logistics Airlift Systems Study

    Science.gov (United States)

    Winston, M. M.; Conner, D. W.

    1980-01-01

    An overview is given of the Cargo/Logistics Airlift Systems Study (CLASS) project which was a 10 man-year effort carried out by two contractor teams, aimed at defining factors impacting future system growth and obtaining market requirements and design guidelines for future air freighters. Growth projection was estimated by two approaches: one, an optimal systems approach with a more efficient and cost effective system considered as being available in 1990; and the other, an evolutionary approach with an econometric behavior model used to predict long term evolution from the present system. Both approaches predict significant growth in demand for international air freighter services and less growth for U.S. domestic services. Economic analysis of air freighter fleet options indicate very strong market appeal of derivative widebody transports in 1990 with little incentive to develop all new dedicated air freighters utilizing the 1990's technology until sometime beyond the year 2000. Advanced air freighters would be economically attractive for a wide range of payload sizes (to 500 metric tons), however, if a government would share in the RD and T costs by virtue of its needs for a slightly modified version of a civil air freighter design (a.g. military airlifter).

  2. NASA Hazard Analysis Process

    Science.gov (United States)

    Deckert, George

    2010-01-01

    This viewgraph presentation reviews The NASA Hazard Analysis process. The contents include: 1) Significant Incidents and Close Calls in Human Spaceflight; 2) Subsystem Safety Engineering Through the Project Life Cycle; 3) The Risk Informed Design Process; 4) Types of NASA Hazard Analysis; 5) Preliminary Hazard Analysis (PHA); 6) Hazard Analysis Process; 7) Identify Hazardous Conditions; 8) Consider All Interfaces; 9) Work a Preliminary Hazard List; 10) NASA Generic Hazards List; and 11) Final Thoughts

  3. Radioactive material air transportation; Transporte aereo de material radioativo

    Energy Technology Data Exchange (ETDEWEB)

    Pader y Terry, Claudio Cosme [Varig Logistica (VARIGLOG), Sao Paulo, SP (Brazil)

    2002-07-01

    As function of the high aggregated value, safety regulations and the useful life time, the air transportation has been used more regularly because is fast, reliable, and by giving great security to the cargo. Based on the International Atomic Energy Agency (IAEA), the IATA (International Air Transportation Association) has reproduced in his dangerous goods manual (Dangerous Goods Regulations - DGR IATA), the regulation for the radioactive material air transportation. Those documents support this presentation.

  4. 77 FR 30542 - Air Cargo Screening Fees

    Science.gov (United States)

    2012-05-23

    ... Security Identification Display Area (SIDA) IDs. Another commenter requested that if TSA intends to limit... obtain SIDA IDs were not included in the fee models for this rulemaking because STAs for holders of SIDA... appreciated TSA's recognition that the STAs performed under the SIDA, Commercial Driver's License-Hazardous...

  5. Biotic and abiotic studies on the biological fate, transport and ecotoxicity of toxic and hazardous waste in the Mississippi River basin

    Energy Technology Data Exchange (ETDEWEB)

    Abdelghani, A.; Pramar, Y.; Mandal, T.

    1996-05-02

    This project assesses the levels of xenobiotics in Devils Swamp and studies their biological fate, transport, ecotoxicity, and potential toxicity to man. This article reports on the following studies: assessment of the acute toxicity of individual xenobiotics and toxicity of organic compounds hexachlorobutadience (HCB) and hexachlorobenzene (HCBD) on juvenile crayfish; determination of the biotic influence of temperature, salinity, pH, oxidation-reduction potential, and sediment composition on the migration of xenobiotics; development of a pharmacokinetics model for xenobiotic absorption and storage, distribution and excretion by fish and crayfish.

  6. 46 CFR 153.436 - Heat transfer fluids: compatibility with cargo.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Heat transfer fluids: compatibility with cargo. 153.436... Equipment Cargo Temperature Control Systems § 153.436 Heat transfer fluids: compatibility with cargo. A heat transfer fluid separated from the cargo by only one wall (for example, the heat transfer fluid in a...

  7. 46 CFR 32.50-30 - Cargo hose-TB/ALL.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Cargo hose-TB/ALL. 32.50-30 Section 32.50-30 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS SPECIAL EQUIPMENT, MACHINERY, AND HULL REQUIREMENTS Pumps, Piping, and Hose for Cargo Handling § 32.50-30 Cargo hose—TB/ALL. Cargo hose carried on...

  8. Determinan Pilihan Pelanggan Terhadap Layanan Cargo Pada PT. Garuda Indonesia Cabang Makassar

    OpenAIRE

    RESPATI., TRIADHI

    2012-01-01

    2012 Penelitian ini bertujuan untuk menganalisis perbedaan pilihan pelanggan terhadap layanan cargo dan memperoleh faktor perbedaan dalam keputusan pilihan pelanggan terhadap layanan cargo. Sedangkan metode analisis yang digunakan adalah analisis deskriptif, analisis kuantitatif dan uji hipotesis. Berdasarkan hasil analisis perbedaan pilihan pelanggan layanan cargo dari masing-masing perusahaan cargo (GIA, Lion Air, Sriwijaya Air dan PT. Wings Air) ternyata ada perbedaan yang signifikan...

  9. Aggregating Secondary Source Data for Air Cargo Prescreening Project

    Data.gov (United States)

    National Aeronautics and Space Administration — We propose to improve the effectiveness of air cargo prescreening by enabling background knowledge about companies and products to be used for threat assessment. The...

  10. Cargo/Weapons Elevator Land Based Engineering Site

    Data.gov (United States)

    Federal Laboratory Consortium — The Cargo and Weapons Facility consists of a suite of full scale and component test facilities contiguously located in building 77H. The site was constructed in 1987...

  11. ATV Cargo Integration Safety Certification Process

    Science.gov (United States)

    Garbellini, L.; Heimann, T. J.

    2005-12-01

    A large number of manned modules are being progressively launched to the International Space Station (ISS) and integrated on-orbit, required to be operated and maintained over long on-orbit stay time, supported by periodical servicing and supply.The European Space Agency (ESA), together with its several industrial aerospace contractors such as Alcatel Alenia Space, is deeply involved in development of space systems hardware, in planning and execution of mission operations, logistics and supply to ISS of consumables, payloads, scientific experiments, orbital replacement units up to station modules and infrastructures, as needed by the ISS utilization cycles. In this frame safety plays a significant role to assure that the safety of the systems is preserved throughout the ISS exploitation phase. This paper summarizes methods and requirements for the safety certification process being implemented to dry cargo integration and accommodation in Jules Verne, the 1st flight of the Automated Transfer Vehicle (ATV), one of the major ESA contributions to the utilization of ISS.

  12. SIMULATIONS FOR ACTIVE INTERROGATION OF HEU IN CARGO CONTAINERS

    Energy Technology Data Exchange (ETDEWEB)

    LEE, SANG Y. [Los Alamos National Laboratory; BEDDINGFIELD, DAVID H. [Los Alamos National Laboratory; PARK, JAEYOUNG [Los Alamos National Laboratory

    2007-01-22

    We describe the results of a Monte Carlo simulation 10 investigate the feasibility of using a pulsed deuterium-tritium (D-T) neutron technique for active interrogation of special nuclear material in cargo containers. Time distributions of fission neutrons from highly enriched uranium induced by a pulsed D-T neutron source were calculated for cargo containers with different hydrogen contents. A simple detector system with polyethylene and cadmium was modeled to calculate the two-group neutron flux at the detector.

  13. Design and Inspection of Liquid Cargo Piping of Chemical Tanker

    Institute of Scientific and Technical Information of China (English)

    Ying Sheng; Jiang Chengsong

    2012-01-01

    There is a great variety of liquid chemicals, and many shipowners are not clear about the cargos their ships will carry at the early stage of the design and construction of chemical tankers. In addition, because of the inclination to choose low cost construction material due to cost concern, the sources of cargos that ships can carry are greatly limited and the operation efficiency will be influenced. What should we do to avoid such situations?

  14. Reducing Aerodynamic Drag on Empty Open Cargo Vehicles

    Science.gov (United States)

    Ross, James C.; Storms, Bruce L.; Dzoan, Dan

    2009-01-01

    Some simple structural modifications have been demonstrated to be effective in reducing aerodynamic drag on vehicles that have empty open cargo bays. The basic idea is to break up the airflow in a large open cargo bay by inserting panels to divide the bay into a series of smaller bays. In the case of a coal car, this involves inserting a small number (typically between two and four) of vertical full-depth or partial-depth panels.

  15. Vibration and acoustic environments for payload/cargo integration

    Science.gov (United States)

    Hill, R. E.; Coody, M. C.

    1983-01-01

    Shuttle orbiter launch vibration and acoustic environments for cargo bay/payload interfaces are predicted. Data acquired during Shuttle flight tests are compared with the preflight estimates. Vibration response data for payload attachment locations are presented, along with acoustic data in the form of noise-level spectra measured at various locations in the cargo bay and space averages of the noise levels. It is shown that the payload-bay vibration and acoustic environments are generally less severe than predicted.

  16. Relationships between Cargo, Cell Penetrating Peptides and Cell Type for Uptake of Non-Covalent Complexes into Live Cells

    Directory of Open Access Journals (Sweden)

    Andrea-Anneliese Keller

    2013-02-01

    Full Text Available Modulating signaling pathways for research and therapy requires either suppression or expression of selected genes or internalization of proteins such as enzymes, antibodies, nucleotide binding proteins or substrates including nucleoside phosphates and enzyme inhibitors. Peptides, proteins and nucleotides are transported by fusing or conjugating them to cell penetrating peptides or by formation of non-covalent complexes. The latter is often preferred because of easy handling, uptake efficiency and auto-release of cargo into the live cell. In our studies complexes are formed with labeled or readily detectable cargoes for qualitative and quantitative estimation of their internalization. Properties and behavior of adhesion and suspension vertebrate cells as well as the protozoa Leishmania tarentolae are investigated with respect to proteolytic activity, uptake efficiency, intracellular localization and cytotoxicity. Our results show that peptide stability to membrane-bound, secreted or intracellular proteases varies between different CPPs and that the suitability of individual CPPs for a particular cargo in complex formation by non-covalent interactions requires detailed studies. Cells vary in their sensitivity to increasing concentrations of CPPs. Thus, most cells can be efficiently transduced with peptides, proteins and nucleotides with intracellular concentrations in the low micromole range. For each cargo, cell type and CPP the optimal conditions must be determined separately.

  17. Phototriggered cargo release from virus-like assemblies.

    Science.gov (United States)

    Brasch, Melanie; Voets, Ilja K; Koay, Melissa S T; Cornelissen, Jeroen J L M

    2013-01-01

    There has been tremendous progress towards the development of responsive polymers that are programmed to respond to an external stimulus such as light, pH and temperature. The unique combination of molecular packaging followed by slow, controlled release of molecular cargo is of particular importance for self-healing materials and the controlled release of drugs. While much focus and progress remains centred around synthetic carriers, viruses and virus-like particles can be considered ideal cargo carriers as they are intrinsically designed to package, protect and deliver nucleic acid cargo to host cells. Here, we report the encapsulation of a stimuli-responsive self-immolative polymer within virus-like assemblies of Cowpea Chlorotic Mottle Virus. Upon photo-irradiation, the self-immolative polymer undergoes a head-to-tail depolymerization into its monomeric subunits, resulting in the slow release of the molecular cargo. We propose that the liberated monomers are small enough to diffuse through the pores of the virus capsid shell and offer an alternative strategy for the controlled loading and unloading of the molecular cargo using viruses as cargo carriers.

  18. COMPUTERS HAZARDS

    Directory of Open Access Journals (Sweden)

    Andrzej Augustynek

    2007-01-01

    Full Text Available In June 2006, over 12.6 million Polish users of the Web registered. On the average, each of them spent 21 hours and 37 minutes monthly browsing the Web. That is why the problems of the psychological aspects of computer utilization have become an urgent research subject. The results of research into the development of Polish information society carried out in AGH University of Science and Technology, under the leadership of Leslaw H. Haber, in the period from 2000 until present time, indicate the emergence dynamic changes in the ways of computer utilization and their circumstances. One of the interesting regularities has been the inverse proportional relation between the level of computer skills and the frequency of the Web utilization.It has been found that in 2005, compared to 2000, the following changes occurred:- A significant drop in the number of students who never used computers and the Web;- Remarkable increase in computer knowledge and skills (particularly pronounced in the case of first years student- Decreasing gap in computer skills between students of the first and the third year; between male and female students;- Declining popularity of computer games.It has been demonstrated also that the hazard of computer screen addiction was the highest in he case of unemployed youth outside school system. As much as 12% of this group of young people were addicted to computer. A lot of leisure time that these youths enjoyed inducted them to excessive utilization of the Web. Polish housewives are another population group in risk of addiction to the Web. The duration of long Web charts carried out by younger and younger youths has been another matter of concern. Since the phenomenon of computer addiction is relatively new, no specific therapy methods has been developed. In general, the applied therapy in relation to computer addition syndrome is similar to the techniques applied in the cases of alcohol or gambling addiction. Individual and group

  19. Logistics worldwide for the whole nuclear cycle. Nuclear Cargo + Service GmbH; Weltweite Logistik im gesamten Nuklear-Kreislauf. Nuclear Cargo + Service GmbH

    Energy Technology Data Exchange (ETDEWEB)

    Geiger, Horst; Schymke, Klaus [Nuclear Cargo + Service GmbH, Hanau (Germany)

    2011-03-15

    Nuclear Cargo + Service GmbH (NCS) offers logistics worldwide for the whole nuclear cycle to fuel manufacturers, reactor operators, and waste management companies. Transport equipment and interim stores are part of the company's facilities. The firm's Front End unit conducts transnational transports of yellow cake, uranium hexafluoride, and enriched uranium and uranium from reprocessing. In the Back End unit, the company performs worldwide transports of spent fuel elements of research reactors. Another key area of activity is shipment of radioactive waste ranging from low-level waste to HAW (highly active waste generating heat). In its Component Disposal area, NCS offers a variety of transport services up to and including large components, e.g. reactor pressure vessels, both on the road and by rail and ship. NCS operates storage halls of its own for storing radioactive materials including radioactive waste. The technical equipment of NCS comprises a large pool of road and rail transport vehicles as well as a great number of vessels for radioactive materials. (orig.)

  20. 49 CFR 171.16 - Detailed hazardous materials incident reports.

    Science.gov (United States)

    2010-10-01

    ... at the reporting person's principal place of business. If the written or electronic Hazardous... Safety Administration, Department of Transportation, Washington, DC 20590-0001, or an electronic... incident involving transportation by aircraft, submit a written or electronic copy of the...

  1. Hazards and hazard combinations relevant for the safety of nuclear power plants

    Science.gov (United States)

    Decker, Kurt; Brinkman, Hans; Raimond, Emmanuel

    2017-04-01

    The potential of the contemporaneous impact of different, yet causally related, hazardous events and event cascades on nuclear power plants is a major contributor to the overall risk of nuclear installations. In the aftermath of the Fukushima accident, which was caused by a combination of severe ground shaking by an earthquake, an earthquake-triggered tsunami and the disruption of the plants from the electrical grid by a seismically induced landslide, hazard combinations and hazard cascades moved into the focus of nuclear safety research. We therefore developed an exhaustive list of external hazards and hazard combinations which pose potential threats to nuclear installations in the framework of the European project ASAMPSAE (Advanced Safety Assessment: Extended PSA). The project gathers 31 partners from Europe, North Amerika and Japan. The list comprises of exhaustive lists of natural hazards, external man-made hazards, and a cross-correlation matrix of these hazards. The hazard list is regarded comprehensive by including all types of hazards that were previously cited in documents by IAEA, the Western European Nuclear Regulators Association (WENRA), and others. 73 natural hazards and 24 man-made external hazards are included. Natural hazards are grouped into seismotectonic hazards, flooding and hydrological hazards, extreme values of meteorological phenomena, rare meteorological phenomena, biological hazards / infestation, geological hazards, and forest fire / wild fire. The list of external man-made hazards includes industry accidents, military accidents, transportation accidents, pipeline accidents and other man-made external events. The large number of different hazards results in the extremely large number of 5.151 theoretically possible hazard combinations (not considering hazard cascades). In principle all of these combinations are possible to occur by random coincidence except for 82 hazard combinations that - depending on the time scale - are mutually

  2. Evidence of nose-to-brain delivery of nanoemulsions: cargoes but not vehicles.

    Science.gov (United States)

    Ahmad, Ejaj; Feng, Yunhai; Qi, Jianping; Fan, Wufa; Ma, Yuhua; He, Haisheng; Xia, Fei; Dong, Xiaochun; Zhao, Weili; Lu, Yi; Wu, Wei

    2017-01-19

    The nose-to-brain pathway has been proven to be a shortcut for direct drug delivery to the brain. However, whether and to what extent nanoparticles can be delivered through this passage is still awaiting validation with evidence. In this study, nose-to-brain transportation of nanoparticles is tracked via fluorescence bioimaging strategies using nanoemulsions (NEs) as model carriers. Identification of NEs in biological tissues is based on the on → off signal switching of a new type of environment-responsive embedded dyes, P2 and P4, and two conventional probes, DiR and coumarin-6 (C6), are embedded to represent the cargoes. Evidence for the translocation of NEs was collected either via live imaging or ex vivo histological examination in rats after nasal administration. Results suggest that NEs with a particle size of about 100 nm, either naked or coated with chitosan, have longer retention duration in nostrils and slower mucociliary clearance than larger ones. P2 signals, representing integral NEs, can be found in mucosa and trigeminal nerves for all size groups, whereas only weak P2 signals are detected in the olfactory bulb for chitosan-coated NEs of 100 nm. Confocal microscopy further confirms the translocation of integral 100 nm NEs in nasal mucosa and along the trigeminal nerve in decremental intensity. Weak signals of the P4 probe, also representing integral NEs, can be detected in the olfactory bulb but few in the brain. NEs as large as 900 nm cannot be transported to the olfactory bulb. However, the DiR or C6 signals that represent the cargoes can be found in significant amounts along the nose-to-brain pathway and finally reach the brain. Evidence shows that integral NEs can be delivered to the olfactory bulb, but few to the brain, whereas the cargoes can be released and permeated into the brain in greater amounts.

  3. 49 CFR 659.31 - Hazard management process.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 7 2010-10-01 2010-10-01 false Hazard management process. 659.31 Section 659.31... Agency § 659.31 Hazard management process. (a) The oversight agency must require the rail transit agency..., operational changes, or other changes within the rail transit environment. (b) The hazard management...

  4. 49 CFR 172.555 - POISON INHALATION HAZARD placard.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false POISON INHALATION HAZARD placard. 172.555 Section... REQUIREMENTS, AND SECURITY PLANS Placarding § 172.555 POISON INHALATION HAZARD placard. (a) Except for size and color, the POISON INHALATION HAZARD placard must be as follows: ER22JY97.025 (b) In addition...

  5. 49 CFR 172.429 - POISON INHALATION HAZARD label.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false POISON INHALATION HAZARD label. 172.429 Section... REQUIREMENTS, AND SECURITY PLANS Labeling § 172.429 POISON INHALATION HAZARD label. (a) Except for size and color, the POISON INHALATION HAZARD label must be as follows: ER22JY97.023 (b) In addition to...

  6. [Robbers on board: exposure to violence, insecurity, and other health hazards among mass transportation workers and passengers in Salvador, Bahia, Brazil].

    Science.gov (United States)

    Paes-Machado, Eduardo; Levenstein, Charles

    2002-01-01

    This paper examines the impact of violent crime on working conditions, health, and security for bus drivers and ticket takers in the mass transportation system in Salvador, Bahia, Brazil. The research included 195 interviews with workers, labor union officials, passengers, management, and police. In the last ten years there have been 20,572 robberies in a fleet of 2,400 buses operated by 10,151 workers, with 67 deaths and more than US$500,000 in company losses. Perpetrators are typically poor, unemployed youths, the majority of whom first offenders, seeking easy money primarily for leisure pursuits. The average "take" from such robberies is minimal. The authors observed a pattern of bus robberies as a psychological power game which, for bus workers, apart from physical injuries and fatalities, generates fear, identity conflicts, tense relations with passengers, and labor conflicts involving the recovery of stolen fares and worker and passenger security issues. The article also outlines and evaluates the efficiency of security measures including the use of lethal force by police.

  7. Failure of cargo aileron’s actuator

    Directory of Open Access Journals (Sweden)

    G. Zucca

    2014-10-01

    Full Text Available During a ferry flight, in a standard operation condition and at cruising level, a military cargo experienced a double hydraulic system failure due to a structural damage of the dual booster actuator. The booster actuator is the main component in mechanism of aileron’s deflection. The crew was able to arrange an emergency landing thanks to the spare oil onboard: load specialists refilled the hydraulic reservoirs. Due to safety concerns and in order to prevent the possibility of other similar incidents, a technical investigation took place. The study aimed to carry out the analysis of root causes of the actuator failure. The Booster actuator is composed mainly by the piston rod and its aluminum external case (AA7049. The assembly has two bronze caps on both ends. These are fixed in position by means of two retainers. At one end of the actuator case is placed a trunnion: a cylindrical protrusion used as a pivoting point on the aircraft. The fracture was located at one end of the case, on the trunnion side, in correspondence to the cap and over the retainer. One of the two fracture surfaces was found separated to the case and with the cap entangled inside. The fracture surfaces of the external case indicated fatigue crack growth followed by ductile separation. The failure analysis was performed by means of optical, metallographic, digital and electronic microscopy. The collected evidences showed a multiple initiation fracture mechanism. Moreover, 3D scanner reconstruction and numerical simulation demonstrated that dimensional non conformances and thermal loads caused an abnormal stress concentration. Stress concentration was located along the case assy outer surface where the fatigue crack originated. The progressive rupture mechanism grew under cyclical axial load due to the normal operations. Recommendations were issued in order to improve dimensional controls and assembly procedures during production and overhaul activities.

  8. Maritime transport operation in conditions of globalization

    Directory of Open Access Journals (Sweden)

    Tomasz Nowosielski

    2011-06-01

    Full Text Available The contemporary world economy is subject to dynamic integration processes that cause the most open countries in the free import and export goods. Intensive trade relations requires intercontinental free access to well-functioning transport systems. In the case of trade with distant partners, especially on other continents, an important criterion for the organization of cargo handling is a long range. Technological development of means of transport has meant that transport services have become a cheap and highly accessible to passengers and cargo.

  9. Dual Transport Process for Targeted Delivery in Porous Media

    Science.gov (United States)

    Deng, W.; Fan, J.

    2015-12-01

    The targeted delivery in porous media is a promising technology to encapsulate the solute (i.e., the cargo) in colloid-like microcapsules (i.e., the carriers), transport the microcapsules in the targeted location in porous media, and then release the solute. While extensive literatures and applications about the drug delivery in human and animal bodies exist, the targeted delivery using similar delivery carriers in subsurface porous media is not well understood. The dual transport process study is an explorative study for the targeted delivery in porous media. While the colloid transport is dominated by the advection process and the solute transport is dominated by the advection-dispersion, the dual transport process is the process with the first step of carrier transport, which is dominated by advection, and then after the release of cargo, the transport of cargo is dominated by advection-dispersion. By applying the random walk particle tracking (RWPT) approach, we investigate how the carriers transport in porous media and how the cargo release mechanisms affect the cargo distribution for the targeted delivery in various patterns of porous media. The RWPT numerical model will be verified against the experimental results of dual transport process in packed-disk 2D micromodels. The understanding of the mechanism of dual transport process is crucial to achieve the potential applications of targeted delivery in improved oil and gas recovery, CO2 sequestration, environmental remediation, and soil biomediation.

  10. Crystallization of Saccharomyces cerevisiae aminopeptidase 1, the major cargo protein of the Cvt pathway

    Energy Technology Data Exchange (ETDEWEB)

    Adachi, Wakana; Suzuki, Nobuo N.; Fujioka, Yuko [Department of Structural Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University, N-12, W-6, Kita-ku, Sapporo 060-0812 (Japan); Suzuki, Kuninori; Ohsumi, Yoshinori [Division of Molecular Cell Biology, National Institute for Basic Biology, 38 Nishigonaka, Myodaiji, Okazaki 444-8585 (Japan); Inagaki, Fuyuhiko, E-mail: finagaki@pharm.hokudai.ac.jp [Department of Structural Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University, N-12, W-6, Kita-ku, Sapporo 060-0812 (Japan)

    2007-03-01

    Aminopeptidase 1, a cargo protein in the cytosol-to-vacuole targeting (Cvt) pathway, was expressed, purified and crystallized in two crystal forms. The vacuole hydrolase aminopeptidase 1 (Ape1) is a cargo protein transported to the vacuole by the cytosol-to-vacuole targeting (Cvt) pathway during conditions of growth and by autophagy during conditions of starvation. After transport to the vacuole, Ape1 is processed into mature Ape1 (mApe1). mApe1 has been expressed, purified and crystallized in two crystal forms. Form I belongs to space group P2{sub 1}, with unit-cell parameters a = 120.6, b = 219.5, c = 133.1 Å, β = 116.5°. Form II belongs to space group R3, with unit-cell parameters a = 141.2, c = 349.4 Å. Diffraction data were collected from these crystals to a resolution of 2.5 Å for form I and 1.83 Å for form II. Self-rotation functions and the volume-to-weight ratio values suggest that forms I and II contain 12 and four mApe1 molecules per asymmetric unit, respectively, and that mApe1 exists as a tetrahedral dodecamer in both crystal forms.

  11. Spectroscopic neutron radiography for a cargo scanning system

    Energy Technology Data Exchange (ETDEWEB)

    Rahon, Jill [Department of Nuclear Science and Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139 (United States); Danagoulian, Areg, E-mail: aregjan@mit.edu [Department of Nuclear Science and Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139 (United States); MacDonald, Thomas D. [Department of Nuclear Science and Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139 (United States); Hartwig, Zachary S. [Plasma Science and Fusion Center, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139 (United States); Lanza, Richard C. [Department of Nuclear Science and Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139 (United States)

    2016-06-01

    Detection of cross-border smuggling of illicit materials and contraband is a challenge that requires rapid, low-dose, and efficient radiographic technology. The work we describe here is derived from a technique which uses monoenergetic gamma rays from low energy nuclear reactions, such as {sup 11}B(d,nγ){sup 12}C, to perform radiographic analysis of shipping containers. Transmission ratios of multiple monoenergetic gamma lines resulting from several gamma producing nuclear reactions can be employed to detect materials of high atomic number (Z), the details of which will be described in a separate paper. Inherent in this particular nuclear reaction is the production of fast neutrons which could enable neutron radiography and further characterization of the effective-Z of the cargo, especially within the range of lower Z. Previous research efforts focused on the use of total neutron counts in combination with X-ray radiography to characterize the hydrogenous content of the cargo. We present a technique of performing transmitted neutron spectral analysis to reconstruct the effective Z and potentially the density of the cargo. This is made possible by the large differences in the energy dependence of neutron scattering cross-sections between hydrogenous materials and those of higher Z. These dependencies result in harder transmission spectra for hydrogenous cargoes than those of non-hydrogenous cargoes. Such observed differences can then be used to classify the cargo based on its hydrogenous content. The studies presented in this paper demonstrate that such techniques are feasible and can provide a contribution to cargo security, especially when used in concert with gamma radiography.

  12. Spectroscopic neutron radiography for a cargo scanning system

    Science.gov (United States)

    Rahon, Jill; Danagoulian, Areg; MacDonald, Thomas D.; Hartwig, Zachary S.; Lanza, Richard C.

    2016-06-01

    Detection of cross-border smuggling of illicit materials and contraband is a challenge that requires rapid, low-dose, and efficient radiographic technology. The work we describe here is derived from a technique which uses monoenergetic gamma rays from low energy nuclear reactions, such as 11B(d,nγ)12C, to perform radiographic analysis of shipping containers. Transmission ratios of multiple monoenergetic gamma lines resulting from several gamma producing nuclear reactions can be employed to detect materials of high atomic number (Z), the details of which will be described in a separate paper. Inherent in this particular nuclear reaction is the production of fast neutrons which could enable neutron radiography and further characterization of the effective-Z of the cargo, especially within the range of lower Z. Previous research efforts focused on the use of total neutron counts in combination with X-ray radiography to characterize the hydrogenous content of the cargo. We present a technique of performing transmitted neutron spectral analysis to reconstruct the effective Z and potentially the density of the cargo. This is made possible by the large differences in the energy dependence of neutron scattering cross-sections between hydrogenous materials and those of higher Z. These dependencies result in harder transmission spectra for hydrogenous cargoes than those of non-hydrogenous cargoes. Such observed differences can then be used to classify the cargo based on its hydrogenous content. The studies presented in this paper demonstrate that such techniques are feasible and can provide a contribution to cargo security, especially when used in concert with gamma radiography.

  13. 78 FR 54775 - Bulk Packaging To Allow for Transfer of Hazardous Liquid Cargoes

    Science.gov (United States)

    2013-09-06

    ... tank or IBC to pump, 10 minutes. Set-up or break-down pump-manifold configuration, 15 minutes. Connect.... Discussion of Comments and Changes A. IBC Standards B. Manifolds C. General Comments D. Clerical Edits V... divided into these three categories: IBC standards, manifolds, and general comments on the rule. A. IBC...

  14. Environmental Assessment Construction of a New Hazardous Cargo Pad Davis-Monthan AFB

    Science.gov (United States)

    2002-11-07

    agency for certain projects. Details of the preparation of this EA are mandated by the Council of Enviromental Quality (CEQ) in the series of...National Ambient Air Quality Standards. Vehicles, aircraft, and other urban sources of pollution locally impact the air quality at all the...alternative locations. Typical air pollutants in the flightline area are carbon monoxide and nitrogen oxides from fuel combustion, and volatile organic

  15. Fire safety of LPG in marine transportation. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Martinsen, W.E.; Johnson, D.W.; Welker, J.R.

    1980-06-01

    This report contains an analytical examination of cargo spill and fire hazard potential associated with the marine handling of liquefied petroleum gas (LPG) as cargo. Principal emphasis was on cargo transfer operations for ships unloading at receiving terminals, and barges loading or unloading at a terminal. Major safety systems, including emergency shutdown systems, hazard detection systems, and fire extinguishment and control systems were included in the analysis. Spill probabilities were obtained from fault tree analyses utilizing composite LPG tank ship and barge designs. Failure rates for hardware in the analyses were generally taken from historical data on similar generic classes of hardware, there being very little historical data on the specific items involved. Potential consequences of cargo spills of various sizes are discussed and compared to actual LPG vapor cloud incidents. The usefulness of hazard mitigation systems (particularly dry chemical fire extinguishers and water spray systems) in controlling the hazards posed by LPG spills and spill fires is also discussed. The analysis estimates the probability of fatality for a terminal operator is about 10/sup -6/ to 10/sup -5/ per cargo transfer operation. The probability of fatality for the general public is substantially less.

  16. Fire safety of LPG in marine transportation. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Martinsen, W.E.; Johnson, D.W.; Welker, J.R.

    1980-06-01

    This report contains an analytical examination of cargo spill and fire hazard potential associated with the marine handling of liquefied petroleum gas (LPG) as cargo. Principal emphasis was on cargo transfer operations for ships unloading at receiving terminals, and barges loading or unloading at a terminal. Major safety systems, including emergency shutdown systems, hazard detection systems, and fire extinguishment and control systems were included in the analysis. Spill probabilities were obtained from fault tree analyses utilizing composite LPG tank ship and barge designs. Failure rates for hardware in the analyses were generally taken from historical data on similar generic classes of hardware, there being very little historical data on the specific items involved. Potential consequences of cargo spills of various sizes are discussed and compared to actual LPG vapor cloud incidents. The usefulness of hazard mitigation systems (particularly dry chemical fire extinguishers and water spray systems) in controlling the hazards posed by LPG spills and spill fires is also discussed. The analysis estimates the probability of fatality for a terminal operator is about 10/sup -6/ to 10/sup -5/ per cargo transfer operation. The probability of fatality for the general public is substantially less.

  17. 米其林:贴近市场,兼容并包%Michelin Launch Special Tyre Product for Cargo Truck

    Institute of Scientific and Technical Information of China (English)

    王作函

    2016-01-01

    Michelin publicly announced on Aug. 31, 2016 in Shenyang that 12R22.5 X GUARD E9 Z, a new tyre product for cargo-truck, was ofifcially launched in the world market. The company believed that this new product is tailor-made for China market in response to the strong request from Chinese customers, and is properly applied to cargo-trucks for various road-condition, which offer the safest and cost-effective solutions to transport lfeet and truck drivers as well.

  18. 14 CFR 417.223 - Flight hazard area analysis.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Flight hazard area analysis. 417.223 Section 417.223 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LAUNCH SAFETY Flight Safety Analysis § 417.223 Flight hazard...

  19. 49 CFR 172.205 - Hazardous waste manifest.

    Science.gov (United States)

    2010-10-01

    ... SECURITY PLANS Shipping Papers § 172.205 Hazardous waste manifest. (a) No person may offer, transport... waste in the United States; and (iv) Retain one copy of the manifest and rail shipping paper in... 49 Transportation 2 2010-10-01 2010-10-01 false Hazardous waste manifest. 172.205 Section 172.205...

  20. REEPs are membrane shaping adapter proteins that modulate specific g protein-coupled receptor trafficking by affecting ER cargo capacity.

    Science.gov (United States)

    Björk, Susann; Hurt, Carl M; Ho, Vincent K; Angelotti, Timothy

    2013-01-01

    Receptor expression enhancing proteins (REEPs) were identified by their ability to enhance cell surface expression of a subset of G protein-coupled receptors (GPCRs), specifically GPCRs that have proven difficult to express in heterologous cell systems. Further analysis revealed that they belong to the Yip (Ypt-interacting protein) family and that some REEP subtypes affect ER structure. Yip family comparisons have established other potential roles for REEPs, including regulation of ER-Golgi transport and processing/neuronal localization of cargo proteins. However, these other potential REEP functions and the mechanism by which they selectively enhance GPCR cell surface expression have not been clarified. By utilizing several REEP family members (REEP1, REEP2, and REEP6) and model GPCRs (α2A and α2C adrenergic receptors), we examined REEP regulation of GPCR plasma membrane expression, intracellular processing, and trafficking. Using a combination of immunolocalization and biochemical methods, we demonstrated that this REEP subset is localized primarily to ER, but not plasma membranes. Single cell analysis demonstrated that these REEPs do not specifically enhance surface expression of all GPCRs, but affect ER cargo capacity of specific GPCRs and thus their surface expression. REEP co-expression with α2 adrenergic receptors (ARs) revealed that this REEP subset interacts with and alter glycosidic processing of α2C, but not α2A ARs, demonstrating selective interaction with cargo proteins. Specifically, these REEPs enhanced expression of and interacted with minimally/non-glycosylated forms of α2C ARs. Most importantly, expression of a mutant REEP1 allele (hereditary spastic paraplegia SPG31) lacking the carboxyl terminus led to loss of this interaction. Thus specific REEP isoforms have additional intracellular functions besides altering ER structure, such as enhancing ER cargo capacity, regulating ER-Golgi processing, and interacting with select cargo proteins

  1. Stokes Efficiency of Molecular Motor-Cargo Systems

    Directory of Open Access Journals (Sweden)

    Hongyun Wang

    2008-01-01

    Full Text Available A molecular motor utilizes chemical free energy to generate a unidirectional motion through the viscous fluid. In many experimental settings and biological settings, a molecular motor is elastically linked to a cargo. The stochastic motion of a molecular motor-cargo system is governed by a set of Langevin equations, each corresponding to an individual chemical occupancy state. The change of chemical occupancy state is modeled by a continuous time discrete space Markov process. The probability density of a motor-cargo system is governed by a two-dimensional Fokker-Planck equation. The operation of a molecular motor is dominated by high viscous friction and large thermal fluctuations from surrounding fluid. The instantaneous velocity of a molecular motor is highly stochastic: the past velocity is quickly damped by the viscous friction and the new velocity is quickly excited by bombardments of surrounding fluid molecules. Thus, the theory for macroscopic motors should not be applied directly to molecular motors without close examination. In particular, a molecular motor behaves differently working against a viscous drag than working against a conservative force. The Stokes efficiency was introduced to measure how efficiently a motor uses chemical free energy to drive against viscous drag. For a motor without cargo, it was proved that the Stokes efficiency is bounded by 100% [H. Wang and G. Oster, (2002]. Here, we present a proof for the general motor-cargo system.

  2. Optimisation of key performance measures in air cargo demand management

    Directory of Open Access Journals (Sweden)

    Alexander May

    2014-03-01

    Full Text Available This article sought to facilitate the optimisation of key performance measures utilised for demand management in air cargo operations. The focus was on the Revenue Management team at Virgin Atlantic Cargo and a fuzzy group decision-making method was used. Utilising intelligent fuzzy multi-criteria methods, the authors generated a ranking order of ten key outcome-based performance indicators for Virgin Atlantic air cargo Revenue Management. The result of this industry-driven study showed that for Air Cargo Revenue Management, ‘Network Optimisation’ represents a critical outcome-based performance indicator. This collaborative study contributes to existing logistics management literature, especially in the area of Revenue Management, and it seeks to enhance Revenue Management practice. It also provides a platform for Air Cargo operators seeking to improve reliability values for their key performance indicators as a means of enhancing operational monitoring power.

  3. Transportation safety training

    Energy Technology Data Exchange (ETDEWEB)

    Jones, E.

    1990-01-01

    Over the past 25 years extensive federal legislation involving the handling and transport of hazardous materials/waste has been passed that has resulted in numerous overlapping regulations administered and enforced by different federal agencies. The handling and transport of hazardous materials/waste involves a significant number of workers who are subject to a varying degree of risk should an accident occur during handling or transport. Effective transportation training can help workers address these risks and mitigate them, and at the same time enable ORNL to comply with the federal regulations concerning the transport of hazardous materials/waste. This presentation will outline how the Environmental and Health Protection Division's Technical Resources and Training Section at the Oak Ridge National Laboratory, working with transportation and waste disposal personnel, have developed and implemented a comprehensive transportation safety training program to meet the needs of our workers while satisfying appropriate federal regulations. 8 refs., 3 tabs.

  4. Working out of generalized dynamic model of cargo fixation with cargo pads jointly with flexible and thrust elements under the action spatial force system

    Directory of Open Access Journals (Sweden)

    Khabibulla TURANOV

    2011-01-01

    Full Text Available The article gives an account of the results of working out a generalized dynamic model of fixation of cargo with pads jointly with flexible and thrust elements. Working out a generalized dynamic model of cargo fixation is rather a complicated problem not in the sense of solving differential equations systems but in the sense of presenting them as a complex mechanical system “cargo – pads – flexible elements – thrust bars”. Generalized dynamic model of cargo with pads observed that this model represents technology of joint work of flexible and thrust fastening means of cargo on rolling stock. In particular, on the basis of this model there can be obtained the technology models of joint work of flexible and elastic fastening means of cargo without pads of fastening flexible elements of cargo with pads without thrust bars and also flexible fastening elements of cargo without pads and thrust bars at asymmetrical and/or symmetrical allocation of cargo in the wagon. A specific feature (novelty feature of the proposed dynamic model is inclusion into the model of both cargo pads and thrust bars which are nailed to the wagon floor close to the butt and lateral sides of cargo.

  5. Simulation of assembling cargo-hold spaceship pallets

    Science.gov (United States)

    Du, Ruizhao; Wang, Pengfei; Wu, Qianru; Jing, Chenchen

    2017-06-01

    The pallet is the load-carrying body between cargo and cargo-hold cabin. Due to the narrow space of cargo-hold cabin, it is difficult for workers to operate. During the installation process of the pallet, it can easily collide with cabin. Based on the installation technology of the pallet, the assembly process of pallet is simulated and analyzed in this paper. The main installation process includes the lifting of pallet, the process of pallet entering the cabin and the assembling of separating device. In the simulation, the practicability of tooling, the standing position of operators, visibility and accessibility of operations are analyzed to determine the risk points in the installation process of pallet. According to the simulation results, feasibility of pallet installation is verified, space requirements for installation are given, and position requirements and posture requirements of workers in the operation process can also be achieved.

  6. Optimizing an undulating magnetic microswimmer for cargo towing

    Science.gov (United States)

    Gutman, Emiliya; Or, Yizhar

    2016-06-01

    One of the promising capabilities of magnetic microswimmers is towing a cargo, which can be used for targeted drug delivery or performing tissue biopsy. A key question is what should be the optimal size ratio between the cargo and the swimmer's flexible tail. This question is addressed here for the simplest theoretical model of a magnetic microswimmer undergoing planar undulations—a spherical load connected by a torsion spring to a rigid slender link. The swimmer's dynamic is formulated and leading-order expressions for its motion are obtained explicitly under small-amplitude approximation. Optimal combinations of magnetic actuation frequency, torsion stiffness, and tail length for maximizing displacement, average speed, or energetic efficiency are obtained. The theoretical results are compared with reported experiments in several types of cargo-towing magnetic microswimmers.

  7. Intentional cargo disruption by nefarious means: Examining threats, systemic vulnerabilities and securitisation measures in complex global supply chains.

    Science.gov (United States)

    McGreevy, Conor; Harrop, Wayne

    2015-01-01

    Global trade and commerce requires products to be securely contained and transferred in a timely way across great distances and between national boundaries. Throughout the process, cargo and containers are stored, handled and checked by a range of authorities and authorised agents. Intermodal transportation involves the use of container ships, planes, railway systems, land bridges, road networks and barges. This paper examines the the nefarious nature of intentional disruption and nefarious risks associated with the movement of cargo and container freight. The paper explores main threats, vulnerabilities and security measures relevant to significant intermodal transit risk issues such as theft, piracy, terrorism, contamination, counterfeiting and product tampering. Three risk and vulnerability models are examined and basic standards and regulations that are relevant to safe and secure transit of container goods across international supply networks are outlined.

  8. Analysis of Arf1 GTPase-dependent membrane binding and remodeling using the exomer secretory vesicle cargo adaptor

    Science.gov (United States)

    Paczkowski, Jon E.; Fromme, J. Christopher

    2016-01-01

    Summary Protein-protein and protein-membrane interactions play a critical role in shaping biological membranes through direct physical contact with the membrane surface. This is particularly evident in many steps of membrane trafficking, in which proteins deform the membrane and induce fission to form transport carriers. The small GTPase Arf1 and related proteins have the ability to remodel membranes by insertion of an amphipathic helix into the membrane. Arf1 and the exomer cargo adaptor coordinate cargo sorting into subset of secretory vesicle carriers in the model organism Saccharomyces cerevisiae. Here, we detail the assays we used to explore the cooperative action of Arf1 and exomer to bind and remodel membranes. We expect these methods are broadly applicable to other small GTPase/effector systems where investigation of membrane binding and remodeling is of interest. PMID:27632000

  9. Combining Radiography and Passive Measurements for Radiological Threat Localization in Cargo

    Energy Technology Data Exchange (ETDEWEB)

    Miller, Erin A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); White, Timothy A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Jarman, Kenneth D. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Kouzes, Richard T. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Kulisek, Jonathan A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Robinson, Sean M. [Pacific Northwest National Lab. (PNNL), Seattle, WA (United States); Wittman, Richard A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2015-10-01

    Detecting shielded special nuclear material (SNM) in a cargo container is a difficult problem, since shielding reduces the amount of radiation escaping the container. Radiography provides information that is complementary to that provided by passive gamma-ray detection systems: while not directly sensitive to radiological materials, radiography can reveal highly shielded regions that may mask a passive radiological signal. Combining these measurements has the potential to improve SNM detection, either through improved sensitivity or by providing a solution to the inverse problem to estimate source properties (strength and location). We present a data-fusion method that uses a radiograph to provide an estimate of the radiation-transport environment for gamma rays from potential sources. This approach makes quantitative use of radiographic images without relying on image interpretation, and results in a probabilistic description of likely source locations and strengths. We present results for this method for a modeled test case of a cargo container passing through a plastic-scintillator-based radiation portal monitor and a transmission-radiography system. We find that a radiograph-based inversion scheme allows for localization of a low-noise source placed randomly within the test container to within 40 cm, compared to 70 cm for triangulation alone, while strength estimation accuracy is improved by a factor of six. Improvements are seen in regions of both high and low shielding, but are most pronounced in highly shielded regions. The approach proposed here combines transmission and emission data in a manner that has not been explored in the cargo-screening literature, advancing the ability to accurately describe a hidden source based on currently-available instrumentation.

  10. A matheuristic for the Cargo Mix Problem with Block Stowage

    DEFF Research Database (Denmark)

    Christensen, Jonas Mark; Pacino, Dario

    2017-01-01

    The cargo-mix problem aims at selecting the amount of containers of a given type to load on a vessel. In this article we present an extended definition that includes the analysis of a circular route with draft restrictions, limitations on expected cargo and the use of a block stowage strategy. A ....... A compact formulation of the problem based on the state-of-the-art heuristic decomposition is shown not to be able to solve the extended problem, thus a matheuristic approach is presented that can achieve high quality results in a matter of seconds....

  11. Solving the Liner Shipping Fleet Repositioning Problem with Cargo Flows

    DEFF Research Database (Denmark)

    Tierney, Kevin; Askelsdottir, Björg; Jensen, Rune Møller;

    2015-01-01

    to reposition vessels as cheaply as possible without disrupting cargo flows. The LSFRP is characterized by chains of interacting activities with a multicommodity flow over paths defined by the activities chosen. Despite its industrial importance, the LSFRP has received little attention in the literature. We...... introduce a novel mathematical model and a simulated annealing algorithm for the LSFRP with cargo flows that makes use of a carefully constructed graph; we evaluate these approaches using real-world data from our industrial collaborator. Additionally, we compare the performance of our approach against...

  12. Column generation approaches to ship scheduling with flexible cargo sizes

    DEFF Research Database (Denmark)

    Brønmo, Geir; Nygreen, Bjørn; Lysgaard, Jens

    cargo sizes to the column generation framework is not straightforward, and we handle the flexible cargo sizes heuristically when solving the subproblems. This leads to convergence issues in the branch-and-price search tree, and the optimal solution cannot be guaranteed. Hence we have introduced a method...... that generates an upper bound on the optimal objective. We have compared our method with an a priori column generation approach, and our computational experiments on real world cases show that the Dantzig-Wolfe approach is faster than the a priori generation of columns, and we are able to deal with larger...

  13. Hazard perception in emergency medical service responders.

    Science.gov (United States)

    Johnston, K A; Scialfa, C T

    2016-10-01

    The perception of on-road hazards is critically important to emergency medical services (EMS) professionals, the patients they transport and the general public. This study compared hazard perception in EMS and civilian drivers of similar age and personal driving experience. Twenty-nine EMS professionals and 24 non-professional drivers were given a dynamic hazard perception test (HPT). The EMS group demonstrated an advantage in HPT that was independent of simple reaction time, another indication of the validity of the test. These results are also consistent with the view that professional driving experience results in changes in the ability to identify and respond to on-road hazards. Directions for future research include the development of a profession-specific hazard perception tool for both assessment and training purposes.

  14. Life Science on the International Space Station Using the Next Generation of Cargo Vehicles

    Science.gov (United States)

    Robinson, J. A.; Phillion, J. P.; Hart, A. T.; Comella, J.; Edeen, M.; Ruttley, T. M.

    2011-01-01

    With the retirement of the Space Shuttle and the transition of the International Space Station (ISS) from assembly to full laboratory capabilities, the opportunity to perform life science research in space has increased dramatically, while the operational considerations associated with transportation of the experiments has changed dramatically. US researchers have allocations on the European Automated Transfer Vehicle (ATV) and Japanese H-II Transfer Vehicle (HTV). In addition, the International Space Station (ISS) Cargo Resupply Services (CRS) contract will provide consumables and payloads to and from the ISS via the unmanned SpaceX (offers launch and return capabilities) and Orbital (offers only launch capabilities) resupply vehicles. Early requirements drove the capabilities of the vehicle providers; however, many other engineering considerations affect the actual design and operations plans. To better enable the use of the International Space Station as a National Laboratory, ground and on-orbit facility development can augment the vehicle capabilities to better support needs for cell biology, animal research, and conditioned sample return. NASA Life scientists with experience launching research on the space shuttle can find the trades between the capabilities of the many different vehicles to be confusing. In this presentation we will summarize vehicle and associated ground processing capabilities as well as key concepts of operations for different types of life sciences research being launched in the cargo vehicles. We will provide the latest status of vehicle capabilities and support hardware and facilities development being made to enable the broadest implementation of life sciences research on the ISS.

  15. Indications of marine bioinvasion from network theory. An analysis of the global cargo ship network

    Science.gov (United States)

    Kölzsch, A.; Blasius, B.

    2011-12-01

    The transport of huge amounts of small aquatic organisms in the ballast tanks and at the hull of large cargo ships leads to ever increasing rates of marine bioinvasion. In this study, we apply a network theoretic approach to examine the introduction of invasive species into new ports by global shipping. This is the first stage of the invasion process where it is still possible to intervene with regulating measures. We compile a selection of widely used and newly developed network properties and apply these to analyse the structure and spread characteristics of the directed and weighted global cargo ship network (GCSN). Our results reveal that the GCSN is highly efficient, shows small world characteristics and is positive assortative, indicating that quick spread of invasive organisms between ports is likely. The GCSN shows strong community structure and contains two large communities, the Atlantic and Pacific trading groups. Ports that appear as connector hubs and are of high centralities are the Suez and Panama Canal, Singapore and Shanghai. Furthermore, from robustness analyses and the network's percolation behaviour, we evaluate differences of onboard and in-port ballast water treatment, set them into context with previous studies and advise bioinvasion management strategies.

  16. Hazard Analysis Database Report

    CERN Document Server

    Grams, W H

    2000-01-01

    The Hazard Analysis Database was developed in conjunction with the hazard analysis activities conducted in accordance with DOE-STD-3009-94, Preparation Guide for U S . Department of Energy Nonreactor Nuclear Facility Safety Analysis Reports, for HNF-SD-WM-SAR-067, Tank Farms Final Safety Analysis Report (FSAR). The FSAR is part of the approved Authorization Basis (AB) for the River Protection Project (RPP). This document describes, identifies, and defines the contents and structure of the Tank Farms FSAR Hazard Analysis Database and documents the configuration control changes made to the database. The Hazard Analysis Database contains the collection of information generated during the initial hazard evaluations and the subsequent hazard and accident analysis activities. The Hazard Analysis Database supports the preparation of Chapters 3 ,4 , and 5 of the Tank Farms FSAR and the Unreviewed Safety Question (USQ) process and consists of two major, interrelated data sets: (1) Hazard Analysis Database: Data from t...

  17. Modeling lahar behavior and hazards

    Science.gov (United States)

    Manville, Vernon; Major, Jon J.; Fagents, Sarah A.

    2013-01-01

    Lahars are highly mobile mixtures of water and sediment of volcanic origin that are capable of traveling tens to > 100 km at speeds exceeding tens of km hr-1. Such flows are among the most serious ground-based hazards at many volcanoes because of their sudden onset, rapid advance rates, long runout distances, high energy, ability to transport large volumes of material, and tendency to flow along existing river channels where populations and infrastructure are commonly concentrated. They can grow in volume and peak discharge through erosion and incorporation of external sediment and/or water, inundate broad areas, and leave deposits many meters thick. Furthermore, lahars can recur for many years to decades after an initial volcanic eruption, as fresh pyroclastic material is eroded and redeposited during rainfall events, resulting in a spatially and temporally evolving hazard. Improving understanding of the behavior of these complex, gravitationally driven, multi-phase flows is key to mitigating the threat to communities at lahar-prone volcanoes. However, their complexity and evolving nature pose significant challenges to developing the models of flow behavior required for delineating their hazards and hazard zones.

  18. 46 CFR 30.10-5a - Cargo area-TB/ALL.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Cargo area-TB/ALL. 30.10-5a Section 30.10-5a Shipping... Cargo area—TB/ALL. The term cargo area means that part of a vessel that includes the cargo tanks and..., all intervening space within, between, below, or outboard of these tanks or holds, and the deck area...

  19. Evaluation of Liquid Dynamic Loads in Slack LNG Cargo Tanks

    Science.gov (United States)

    1980-05-01

    Absirect This report provides an evaluacion of dynimi,c sloshing loads in slack LNG cargo tanks. A comprehensive review of vcrid4ide scale model sloshing...Cycles at Transducer Location 1 for a 25% Full Tank .......................................... 69 IV-7 Integrated Nondimensional Pressure Values for...Location 14 for a 75% Full Tank ......................................................... 70 IV 12 Integrated Nondimensional Pressure Values for 200

  20. Shift designs for freight handling personnel at air cargo terminals

    DEFF Research Database (Denmark)

    Rong, Aiying; Grunow, Martin

    2009-01-01

    This paper presents an integrated mixed integer linear programming (MILP) model for determining manpower requirements and related personnel shift designs for the build-up and break-down of the unit load devices (ULDs) at the air cargo terminal to minimize manpower costs. To utilize the manpower...