Malaria haplotype frequency estimation.
Wigger, Leonore; Vogt, Julia E; Roth, Volker
2013-09-20
We present a Bayesian approach for estimating the relative frequencies of multi-single nucleotide polymorphism (SNP) haplotypes in populations of the malaria parasite Plasmodium falciparum by using microarray SNP data from human blood samples. Each sample comes from a malaria patient and contains one or several parasite clones that may genetically differ. Samples containing multiple parasite clones with different genetic markers pose a special challenge. The situation is comparable with a polyploid organism. The data from each blood sample indicates whether the parasites in the blood carry a mutant or a wildtype allele at various selected genomic positions. If both mutant and wildtype alleles are detected at a given position in a multiply infected sample, the data indicates the presence of both alleles, but the ratio is unknown. Thus, the data only partially reveals which specific combinations of genetic markers (i.e. haplotypes across the examined SNPs) occur in distinct parasite clones. In addition, SNP data may contain errors at non-negligible rates. We use a multinomial mixture model with partially missing observations to represent this data and a Markov chain Monte Carlo method to estimate the haplotype frequencies in a population. Our approach addresses both challenges, multiple infections and data errors.
Maximum-likelihood estimation of haplotype frequencies in nuclear families.
Becker, Tim; Knapp, Michael
2004-07-01
The importance of haplotype analysis in the context of association fine mapping of disease genes has grown steadily over the last years. Since experimental methods to determine haplotypes on a large scale are not available, phase has to be inferred statistically. For individual genotype data, several reconstruction techniques and many implementations of the expectation-maximization (EM) algorithm for haplotype frequency estimation exist. Recent research work has shown that incorporating available genotype information of related individuals largely increases the precision of haplotype frequency estimates. We, therefore, implemented a highly flexible program written in C, called FAMHAP, which calculates maximum likelihood estimates (MLEs) of haplotype frequencies from general nuclear families with an arbitrary number of children via the EM-algorithm for up to 20 SNPs. For more loci, we have implemented a locus-iterative mode of the EM-algorithm, which gives reliable approximations of the MLEs for up to 63 SNP loci, or less when multi-allelic markers are incorporated into the analysis. Missing genotypes can be handled as well. The program is able to distinguish cases (haplotypes transmitted to the first affected child of a family) from pseudo-controls (non-transmitted haplotypes with respect to the child). We tested the performance of FAMHAP and the accuracy of the obtained haplotype frequencies on a variety of simulated data sets. The implementation proved to work well when many markers were considered and no significant differences between the estimates obtained with the usual EM-algorithm and those obtained in its locus-iterative mode were observed. We conclude from the simulations that the accuracy of haplotype frequency estimation and reconstruction in nuclear families is very reliable in general and robust against missing genotypes.
The discrete Laplace exponential family and estimation of Y-STR haplotype frequencies
Andersen, Mikkel Meyer; Eriksen, Poul Svante; Morling, Niels
2013-01-01
Estimating haplotype frequencies is important in e.g. forensic genetics, where the frequencies are needed to calculate the likelihood ratio for the evidential weight of a DNA profile found at a crime scene. Estimation is naturally based on a population model, motivating the investigation...... of the Fisher-Wright model of evolution for haploid lineage DNA markers. An exponential family (a class of probability distributions that is well understood in probability theory such that inference is easily made by using existing software) called the 'discrete Laplace distribution' is described. We illustrate...
Xu Ke
2007-06-01
Full Text Available Abstract Background Tests for association between a haplotype and disease are commonly performed using a likelihood ratio test for heterogeneity between case and control haplotype frequencies. Using data from a study of association between heroin dependence and the DRD2 gene, we obtained estimated haplotype frequencies and the associated likelihood ratio statistic using two different computer programs, MLOCUS and GENECOUNTING. We also carried out permutation testing to assess the empirical significance of the results obtained. Results Both programs yielded similar, though not identical, estimates for the haplotype frequencies. MLOCUS produced a p value of 1.8*10-15 and GENECOUNTING produced a p value of 5.4*10-4. Permutation testing produced a p value 2.8*10-4. Conclusion The fact that very large differences occur between the likelihood ratio statistics from the two programs may reflect the fact that the haplotype frequencies for the combined group are not constrained to be equal to the weighted averages of the frequencies for the cases and controls, as they would be if they were directly observed rather than being estimated. Minor differences in haplotype frequency estimates can result in very large differences in the likelihood ratio statistic and associated p value.
Fast and accurate haplotype frequency estimation for large haplotype vectors from pooled DNA data
Iliadis Alexandros
2012-10-01
Full Text Available Abstract Background Typically, the first phase of a genome wide association study (GWAS includes genotyping across hundreds of individuals and validation of the most significant SNPs. Allelotyping of pooled genomic DNA is a common approach to reduce the overall cost of the study. Knowledge of haplotype structure can provide additional information to single locus analyses. Several methods have been proposed for estimating haplotype frequencies in a population from pooled DNA data. Results We introduce a technique for haplotype frequency estimation in a population from pooled DNA samples focusing on datasets containing a small number of individuals per pool (2 or 3 individuals and a large number of markers. We compare our method with the publicly available state-of-the-art algorithms HIPPO and HAPLOPOOL on datasets of varying number of pools and marker sizes. We demonstrate that our algorithm provides improvements in terms of accuracy and computational time over competing methods for large number of markers while demonstrating comparable performance for smaller marker sizes. Our method is implemented in the "Tree-Based Deterministic Sampling Pool" (TDSPool package which is available for download at http://www.ee.columbia.edu/~anastas/tdspool. Conclusions Using a tree-based determinstic sampling technique we present an algorithm for haplotype frequency estimation from pooled data. Our method demonstrates superior performance in datasets with large number of markers and could be the method of choice for haplotype frequency estimation in such datasets.
Day Ian NM
2007-11-01
Full Text Available Abstract Background The frequency of a haplotype comprising one allele at each of two loci can be expressed as a cubic equation (the 'Hill equation', the solution of which gives that frequency. Most haplotype and linkage disequilibrium analysis programs use iteration-based algorithms which substitute an estimate of haplotype frequency into the equation, producing a new estimate which is repeatedly fed back into the equation until the values converge to a maximum likelihood estimate (expectation-maximisation. Results We present a program, "CubeX", which calculates the biologically possible exact solution(s and provides estimated haplotype frequencies, D', r2 and χ2 values for each. CubeX provides a "complete" analysis of haplotype frequencies and linkage disequilibrium for a pair of biallelic markers under situations where sampling variation and genotyping errors distort sample Hardy-Weinberg equilibrium, potentially causing more than one biologically possible solution. We also present an analysis of simulations and real data using the algebraically exact solution, which indicates that under perfect sample Hardy-Weinberg equilibrium there is only one biologically possible solution, but that under other conditions there may be more. Conclusion Our analyses demonstrate that lower allele frequencies, lower sample numbers, population stratification and a possible |D'| value of 1 are particularly susceptible to distortion of sample Hardy-Weinberg equilibrium, which has significant implications for calculation of linkage disequilibrium in small sample sizes (eg HapMap and rarer alleles (eg paucimorphisms, q
The discrete Laplace exponential family and estimation of Y-STR haplotype frequencies
Andersen, Mikkel Meyer; Eriksen, Poul Svante; Morling, Niels
2013-01-01
Estimating haplotype frequencies is important in e.g. forensic genetics, where the frequencies are needed to calculate the likelihood ratio for the evidential weight of a DNA profile found at a crime scene. Estimation is naturally based on a population model, motivating the investigation of the F...... on a normal computer. This method was implemented in the freely available open source software R that is supported on Linux, MacOS and MS Windows....
Greyling Barend J
2010-04-01
Full Text Available Abstract Background The Y-chromosomal diversity in the African buffalo (Syncerus caffer population of Kruger National Park (KNP is characterized by rainfall-driven haplotype frequency shifts between year cohorts. Stable Y-chromosomal polymorphism is difficult to reconcile with haplotype frequency variations without assuming frequency-dependent selection or specific interactions in the population dynamics of X- and Y-chromosomal genes, since otherwise the fittest haplotype would inevitably sweep to fixation. Stable Y-chromosomal polymorphism due one of these factors only seems possible when there are Y-chromosomal distorters of an equal sex ratio, which act by negatively affecting X-gametes, or Y-chromosomal suppressors of a female-biased sex ratio. These sex-ratio (SR genes modify (suppress gamete transmission in their own favour at a fitness cost, allowing for stable polymorphism. Results Here we show temporal correlations between Y-chromosomal haplotype frequencies and foetal sex ratios in the KNP buffalo population, suggesting SR genes. Frequencies varied by a factor of five; too high to be alternatively explained by Y-chromosomal effects on pregnancy loss. Sex ratios were male-biased during wet and female-biased during dry periods (male proportion: 0.47-0.53, seasonally and annually. Both wet and dry periods were associated with a specific haplotype indicating a SR distorter and SR suppressor, respectively. Conclusions The distinctive properties suggested for explaining Y-chromosomal polymorphism in African buffalo may not be restricted to this species alone. SR genes may play a broader and largely overlooked role in mammalian sex-ratio variation.
Existence of General Competitive Equilibria: A Variational Approach
G. Anello
2016-01-01
Full Text Available We study the existence of general competitive equilibria in economies with agents and goods in a finite number. We show that there exists a Walras competitive equilibrium in all ownership private economies such that, for all consumers, initial endowments do not contain free goods and utility functions are locally Lipschitz quasiconcave. The proof of the existence of competitive equilibria is based on variational methods by applying a theoretical existence result for Generalized Quasi Variational Inequalities.
Ding, Xiangdong; Zhang, Qin; Flury, Christine; Simianer, Henner
2006-01-01
Recent literature has suggested that haplotype inference through close relatives, especially from nuclear families can be an alternative strategy in determining the linkage phase. In this paper, haplotype reconstruction and estimation of haplotype frequencies via expectation maximization (EM) algorithm including nuclear families with only one parent available is proposed. Parent and his (her) child are treated as parent-child pair with one shared haplotype. This reduces the number of potential haplotype pairs for both parent and child separately, resulting in a higher accuracy of the estimation. In a series of simulations, the comparisons of PHASE, GENEHUNTER, EM-based approach for complete nuclear families and our approach are carried out. In all situations, EM-based approach for trio data is comparable but slightly worse error rate than PHASE, our approach is slightly better and much faster than PHASE for incomplete trios, the performance of GENEHUNTER is very bad in simple nuclear family settings and dramatically decreased with the number of markers being increased. On the other hand, the comparison result of different sampling designs demonstrates that sampling trios is the most efficient design to estimate haplotype frequencies in populations under same genotyping cost.
Rh phenotype, allele and haplotype frequencies among 51,857 blood donors in North India.
Makroo, Raj; Gupta, Richa; Bhatia, Aakanksha; Rosamma, Nakamatathil L
2014-01-01
This study was performed to provide information on the frequencies of Rh antigens, alleles, phenotypes, and haplotypes from our region in India and to compare them with those from other races. This observational study was conducted on blood donors from March 2009 to August 2011 using a fully automated system for Rh typing of blood cells. The data were collected and calculations done to determine the antigen, phenotypes, allele and haplotype frequencies. The chi square test was used for comparisons between the results of our study and those of other studies. A total of 51,857 donors were included in this study. The most common Rh antigen found was "e". DCCee was the most prevalent phenotype in our study with the phenotype distribution being significantly different between our study and other studies from different regions of the world. We have determined the prevalence of Rh antigens and Rh phenotypes in the North Indian blood donor population and derived the allele and haplotype frequencies in the same population. The Rh blood group distribution in this population was different from that in other populations.
Variational symmetries as the existence of ignorable coordinates
del Castillo, G F Torres
2016-01-01
It is shown that given a Lagrangian for a system with a finite number of degrees of freedom, the existence of a variational symmetry is equivalent to the existence of coordinates in the extended configuration space such that one of the coordinates is ignorable.
Hooft, van W.F.; Prins, H.H.T.; Getz, W.M.; Jolles, A.E.; Wieren, van S.E.; Greyling, B.J.; Helden, P.D.; Bastos, A.D.S.
2010-01-01
Background - The Y-chromosomal diversity in the African buffalo (Syncerus caffer) population of Kruger National Park (KNP) is characterized by rainfall-driven haplotype frequency shifts between year cohorts. Stable Y-chromosomal polymorphism is difficult to reconcile with haplotype frequency variati
Existence theorems of solution to variational inequality problems
无
2001-01-01
This paper introduces a new concept of exceptional family forvariational inequality problems with a general convex constrained set. By using this new concept, the authors establish a general sufficient condition for the existence of a solution to the problem. This condition is weaker than many known solution conditions and it is also necessary for pseudomonotone variational inequalities. Sufficient solution conditions for a class of nonlinear complementarity problems with P0 mappings are also obtained.
On existence and uniqueness of solutions for variational data assimilation
Bröcker, Jochen
2017-04-01
Data assimilation is a term from the geosciences and refers to methods for estimating orbits of dynamical models from observations. Variational techniques for data assimilation estimate these orbits by minimising an appropriate cost functional which takes the error with respect to the observations but also deviations of the orbits from the model equations into account. Such techniques are very important in practice. In this contribution, the problem of existence and uniqueness of solutions to variational data assimilation is investigated. Under mild hypotheses a solution to this problem exists. The problem of uniqueness is investigated as well, and several results (which all have analogues in optimal control) are established in the present context. The value function is introduced as the cost of an optimal trajectory starting from a given initial condition. The necessary conditions in combination with an envelope theorem can be used to demonstrate that the solution is unique if and only if the value function is differentiable at the given initial condition. This occurs for all initial conditions except maybe on a set of Lebesgue measure zero. Several examples are studied which demonstrate that non-uniqueness of solutions cannot be ruled out altogether though, which has important consequences in practice. References: J. Bröcker, "Existence and Uniqueness For Four Dimensional Variational Data Assimilation in Discrete Time.", SIAM Journal of Applied Dynamical Systems (accepted).
MalHaploFreq: A computer programme for estimating malaria haplotype frequencies from blood samples
Smith Thomas A
2008-07-01
Full Text Available Abstract Background Molecular markers, particularly those associated with drug resistance, are important surveillance tools that can inform policy choice. People infected with falciparum malaria often contain several genetically-distinct clones of the parasite; genotyping the patients' blood reveals whether or not the marker is present (i.e. its prevalence, but does not reveal its frequency. For example a person with four malaria clones may contain both mutant and wildtype forms of a marker but it is not possible to distinguish the relative frequencies of the mutant and wildtypes i.e. 1:3, 2:2 or 3:1. Methods An appropriate method for obtaining frequencies from prevalence data is by Maximum Likelihood analysis. A computer programme has been developed that allows the frequency of markers, and haplotypes defined by up to three codons, to be estimated from blood phenotype data. Results The programme has been fully documented [see Additional File 1] and provided with a user-friendly interface suitable for large scale analyses. It returns accurate frequencies and 95% confidence intervals from simulated dataset sets and has been extensively tested on field data sets. Additional File 1 User manual for MalHaploFreq. Click here for file Conclusion The programme is included [see Additional File 2] and/or may be freely downloaded from 1. It can then be used to extract molecular marker and haplotype frequencies from their prevalence in human blood samples. This should enhance the use of frequency data to inform antimalarial drug policy choice. Additional File 2 executable programme compiled for use on DOS or windows Click here for file
Zachary, A A; Bias, W B; Johnson, A; Rose, S M; Leffell, M S
2001-10-01
HLA typing was performed on 977 African Americans residing throughout most of the United States. Class I and class II antigens and class II alleles were defined for all individuals and class I alleles were determined for a subset of individuals. The occurrence of 854 of the individuals in family groups permitted direct counting of allele and haplotype frequencies. The data were analyzed for antigen, allele, and haplotype frequencies; recombination frequencies; segregation distortion; distribution of haplotype frequencies; linkage disequilibria; and geographic distribution of DR antigens. Tables of the antigen, allele, the most common two and three point haplotypes, and 88 extended haplotypes that include class I and class II alleles are presented. Notable findings include a lower than expected frequency of recombination between the B and DR loci (theta= 0.0013), lower than expected frequency of inheritance (44.5% vs 54.5%) of the DRB1*1503; DQB1*0602 haplotype, lower than anticipated linkage disequilibrium values for DR; DQ haplotypes, and a skewed geographic distribution of DR antigens.
Existence theorems of solution to variational inequality problems
ZHANG; Liping
2001-01-01
［1］Harker, P. T., Pang, J. S., Finite-dimensional variational inequality and nonlinear complementarity problems: A survey of theory, algorithm, and applications, Mathematical Programming, 1990, 48(2): 161.［2］Eaves, B. C., The linear complementarity problem, Management Science, 1971, 17(3): 612.［3］Eaves, B. C., On the basic theorem of complementarity problem, Math. Programming, 1971, 1(1): 68.［4］Karamardian, S., Generalized complementarity problem, J. Optim. Theory Appl., 1971, 8(1): 161.［5］Kojima, M., A unification of the existence theorems of the nonlinear complementarity problem, Math. Programming, 1975, 9(2): 257.［6］Moré, J. J., Classes of functions and feasibility conditions in nonlinear complementarity problems, Math. Programming, 1974, 6(2): 327.［7］Moré, J. J., Coercivity conditions in nonlinear complementarity problems, SIAM Rev., 1974, 16(1): 1.［8］Smith, T. E., A solution condition for complementarity problems, with an application to spatial price equilibrium, Appl. Math. Computation, 1984, 15(1): 61.［9］Isac, G., Bulavaski, V., Kalashnikov, V., Exceptional families, topological degree and complementarity problems, J. Global Optim., 1997, 10(2): 207.［10］Zhao, Y. B., Han, J. Y., Qi, H. D., Exceptional families and existence theorems for variational inequality problems, J. Optim. Theory Appl., 1999, 101(2): 475.［11］Zhao, Y. B., Han, J. Y., Exceptional family of elements for a variational inequality problem and its applications, Journal of Global Optimization, 1999, 14(2): 313.［12］Zhao, Y. B., Exceptional families and finite dimensional variational inequalities over polyhedral convex sets, Appl. Math. Computation, 1997, 87(1): 111.［13］Lloyd, N. Q., Degree Theory, Cambridge: Cambridge University Press, 1978, 6—54.［14］Ortega, J. M., Rheinholdt, W. C., Iterative Solution of Nonlinear Equations in Several Variables, New York: Academic Press, 1970, 30—45.［15］Isac, G., Obuchowska, W. T., Functions
Park, H; Lee, Y-J; Song, E Y; Park, M H
2016-10-01
The human leucocyte antigen (HLA) system is the most polymorphic genetic system in humans, and HLA matching is crucial in organ transplantation, especially in hematopoietic stem cell transplantation. We investigated HLA-A, HLA-B and HLA-DRB1 allele and haplotype frequencies at allelic level in 10 918 Koreans from bone marrow donor registry in Korea. Intermediate resolution HLA typing was performed using Luminex technology (Wakunaga, Japan), and additional allelic level typing was performed using PCR-single-strand conformation polymorphism method and/or sequence-based typing (Abbott Molecular, USA). Allele and haplotype frequencies were calculated by direct counting and maximum likelihood methods, respectively. A total of 39 HLA-A, 66 HLA-B and 47 HLA-DRB1 alleles were identified. High-frequency alleles found at a frequency of ≥5% were 6 HLA-A (A*02:01, *02:06, *11:01, *24:02, *31:01 and *33:03), 6 HLA-B (B*15:01, *35:01, *44:03, *51:01, 54:01 and *58:01) and 8 HLA-DRB1 (DRB1*01:01, *04:05, *04:06, *07:01, *08:03, *09:01, *13:02 and *15:01) alleles. At each locus, A*02, B*15 and DRB1*14 generic groups were most diverse at allelic level, consisting of 9, 12 and 11 different alleles, respectively. A total of 366, 197 and 21 different HLA-A-B-DRB1 haplotypes were estimated with frequencies of ≥0.05%, ≥0.1% and ≥0.5%, respectively. The five most common haplotypes with frequencies of ≥2.0% were A*33:03-B*44:03-DRB1*13:02 (4.97%), A*33:03-B*58:01-DRB1*13:02, A*33:03-B*44:03-DRB1*07:01, A*24:02-B*07:02-DRB1*01:01 and A*24:02-B*52:01-DRB1*15:02. Among 34 serologic HLA-A-B-DR haplotypes with frequencies of ≥0.5%, 17 haplotypes revealed allele-level diversity and majority of the allelic variation was arising from A2, A26, B61, B62, DR4 and DR14 specificities. Haplotype diversity obtained in this study is the most comprehensive data thus far reported in Koreans, and the information will be useful for unrelated stem cell transplantation as well as for disease
Yazmin Rocío Árias-Murillo
2010-12-01
Full Text Available Introduction: The high polymorphism of the HLA system allows its typification to be used as valuable tool in establishing association to various illnesses, immune and genetic profiles; it also provides a guide to identifying compatibility among donors and receptors of organs transplants.Objective: To establish HLA-A, HLA-B, and HLA.DRB1 allele, genotype and haplotype frequencies among patients treated at Clinica Colsanitas SA.Methods: 561 patients coming from different regions in Colombia, who were attended in 8 centers of the clinical laboratory of the Clinica Colsanitas in different cities of the country from January 2004 to August 2008, were included in this study. All were HLA-A,-B, and -DRB1 typified via SSP PCR. Allele, genotype and haplotype frequencies were estimated with STATA Software Version 9.0 and the GENEPOP genetic analysis package.Results: 19, 28, and 15 different alleles were identified for loci HLA-A,-B and -DRB1, respectively. Alleles found most frequently were A*24 (26.2%, A*02 (26%, B*35(22.7%, and DRB1*04 (24%. The most frequent genotypes were A*02,24 (14.2%, B*07,35 (5.5%, DRB1*01,04, and DRB1*04,04 (6.9%; while most the frequent haplotypes were HLA A*24, B*35 (9.2%, A*24, DRB1*04 (8.1%; B*35, DRB1*04 (7.8%, A*2 DRB1*04 (7.4%.Conclusion: The results obtained provide a useful reference framework for the population studied, allowing compatibility probability calculations to be performed for organ transplants.
Yamín Rocío Arias-Murillo
2011-01-01
Full Text Available Introduction: The high polymorphism of the HLA system allows its typification to be used as valuable tool in establishing association to various illnesses, immune and genetic profiles; it also provides a guide to identifying compatibility among donors and receptors of organs transplants. Objective: To establish HLA-A, HLA-B, and HLA.DRB1 allele, genotype and haplotype frequencies among patients treated at Clinica Colsanitas SA. Methods: 561 patients coming from different regions in Colombia, who were attended in 8 centers of the clinical laboratory of the Clinica Colsanitas in different cities of the country from January 2004 to August 2008, were included in this study. All were HLA-A,-B, and -DRB1 typified via SSP PCR. Allele, genotype and haplotype frequencies were estimated with STATA Software Version 9.0 and the GENEPOP genetic analysis package. Results: 19, 28, and 15 different alleles were identified for loci HLA-A,-B and -DRB1, respectively. Alleles found most frequently were A*24 (26.2%, A*02 (26%, B*35(22.7%, and DRB1*04 (24%. The most frequent genotypes were A*02,24 (14.2%, B*07,35 (5.5%, DRB1*01,04, and DRB1*04,04 (6.9%; while most the frequent haplotypes were HLA A*24, B*35 (9.2%, A*24, DRB1*04 (8.1%; B*35, DRB1*04 (7.8%, A*2 DRB1*04 (7.4%. Conclusion: The results obtained provide a useful reference framework for the population studied, allowing compatibility probability calculations to be performed for organ transplants.
Moore Stephen
2011-06-01
and fertility traits in Holstein cattle. We conclude that high-resolution genome scans of selection signatures can be used to identify genomic regions contributing to within- and inter-breed phenotypic variation.
Marlene Silva Bardi; Luciana Ribeiro Jarduli; Adylson Justino Jorge; Rossana Batista Oliveira Godoy Camargo; Fernando Pagotto Carneiro; Jair Roberto Gelinski; Roseclei Assunção Feliciano Silva; Edson Lopes Lavado
2012-01-01
BACKGROUND: Knowledge of allele and haplotype frequencies of the human leukocyte antigen (HLA) system is important in the search for unrelated bone marrow donors. The Brazilian population is very heterogeneous and the HLA system is highly informative of populations because of the high level of polymorphisms. AIM: The aim of this study was to characterize the immunogenetic profile of ethnic groups (Caucasians, Afro-Brazilians and Asians) in the north of Parana State. METHODS: A study was carri...
Papassavas, E C; Spyropoulou-Vlachou, M; Papassavas, A C; Schipper, R F; Doxiadis, I N; Stavropoulos-Giokas, C
2000-06-01
In the present study, DNA typing for HLA-A, C, B, DRB1, DRB3, DRB4, DRB5, DQA1, DQB1, and DPB1 was performed for 246 healthy, unrelated Greek volunteers of 20-59 years of age. Phenotype, genotype frequencies, Hardy-Weinberg equilibrium fit, and 3-locus haplotype frequencies for HLA-A, C, B, HLA-A, B, DRB1, HLA-DRB1, DQA1, DQB1, and HLA-DRB1, DQB1, DPB1 were calculated. Furthermore, linkage disequilibrium, deltas, relative deltas and p-values for significance of the deltas were defined. The population studied is in Hardy-Weinberg equilibrium, and many MHC haplotypes are in linkage disequilibrium. The most frequent specificities were HLA-A*02 (phenotype frequency = 44.3%) followed by HLA-A*24 (27.2%), HLA-B*51 (28.5%), HLA-B*18 (26.8%) and HLA-B*35 (26.4%) and HLA-Cw*04 (30.1%) and HLA-Cw*12 (26.8%). The most frequent MHC class II alleles were HLA-DRB1*1104 (34.1%), HLA-DQB1*0301 (54.5%) and HLA-DPB1*0401 with a phenotype frequency of 59.8%. The most prominent HLA-A, C, B haplotypes were HLA-A*24, Cw*04, B*35, and HLA-A*02, Cw*04, B*35, each of them observed in 21/246 individuals. The most frequent HLA-A, B, DRB1 haplotype was HLA-A*02, B*18, DRB1*1104 seen in 20/246 individuals, while the haplotype HLA-DRB1*1104, DQB1*0301, DPB1*0401 was found in 49/246 individuals. Finally, the haplotype DRB1*1104, DQA1*0501, DQB1*0301 was observed in 83/246 individuals. These results can be used for the estimation of the probability of finding a suitable haplotypically identical related or unrelated stem cell donor for patients of Greek ancestry. In addition, they can be used for HLA and disease association studies, genetic distance studies in the Balkan and Mediterranean area, paternity cases, and matching probability calculations for the optimal allocation of kidneys in Greece.
Gao Da-peng; Feng Shi-qiang
2014-01-01
In this paper, we introduce and study a class of generalized vector quasi-variational-like inequality problems, which includes generalized nonlinear vector vari-ational inequality problems, generalized vector variational inequality problems and generalized vector variational-like inequality problems as special cases. We use the maximal element theorem with an escaping sequence to prove the existence results of a solution for generalized vector quasi-variational-like inequalities without any mono-tonicity conditions in the setting of locally convex topological vector space.
曾六川
2003-01-01
A new class of general multivalued mixed implicit quasi-variational inequalities in a real Hilbert space was introduced, which includes the known class of generalized mixed implicit quasi-variational inequalities as a special case, introduced and studied by Ding Xieping. The auxiliary variational principle technique was applied to solve this class of general multivalued mixed implicit quasi-variational inequalities. Firstly, a new auxiliary variational inequality with a proper convex, lower semicontinuous, binary functional was defined and a suitable functional was chosen so that its unique minimum point is equivalent to the solution of such an auxiliary variational inequality. Secondly, this auxiliary variational inequality was utilized to construct a new iterative algorithm for computing approximate solutions to general multivalued mixed implicit quasi-variational inequalities. Here, the equivalence guarantees that the algorithm can generate a sequence of approximate solutions.Finally, the existence of solutions and convergence of approximate solutions for general multivalued mixed implicit quasi-variational inequalities are proved. Moreover, the new convergerce criteria for the algorithm were provided. Therefore, the results give an affirmative anwer to the open question raised by M . A. Noor , and extend and improve the earlier and recent results for various variational inequalities and complementarity problems including the corresponding results for mixed variational inequalities, mixed quasi-variational inequalities and quasi-complementarity problems involving the single-valued and set-valued mappings in the recent literature.
ZENG Luchuan
2004-01-01
The purpose of this paper is to introduce and study a new class of generalized strongly mixed implicit quasi-variational inequalities in Hilbert spaces, which includes the known class of generalized mixed implicit quasi-variational inequalities as a special case.By applying the auxiliary variational principle technique, the existence of solutions for this class of quasi-variational inequalities is proved. Moreover, a new iterative algorithm for computing approximate solutions is constructed and the convergence criteria for this iterative algorithm are also established.
Existence and Algorithm for Solving the System of Mixed Variational Inequalities in Banach Spaces
Siwaporn Saewan
2012-01-01
Full Text Available The purpose of this paper is to study the existence and convergence analysis of the solutions of the system of mixed variational inequalities in Banach spaces by using the generalized f projection operator. The results presented in this paper improve and extend important recent results of Zhang et al. (2011 and Wu and Huang (2007 and some recent results.
Existence and decay of solutions of some nonlinear parabolic variational inequalities
Mitsuhiro Nakao
1980-01-01
Full Text Available This paper discusses the existence and decay of solutions u(t of the variational inequality of parabolic type: ≧0for ∀v∈Lp([0,∞;V(p≧2 with v(t∈K a.e. in [0,∞, where K is a closed convex set of a separable uniformly convex Banach space V, A is a nonlinear monotone operator from V to V* and B is a nonlinear operator from Banach space W to W*. V and W are related as V⊂W⊂H for a Hilbert space H. No monotonicity assumption is made on B.
Marlene Silva Bardi
2012-01-01
Full Text Available BACKGROUND: Knowledge of allele and haplotype frequencies of the human leukocyte antigen (HLA system is important in the search for unrelated bone marrow donors. The Brazilian population is very heterogeneous and the HLA system is highly informative of populations because of the high level of polymorphisms. AIM: The aim of this study was to characterize the immunogenetic profile of ethnic groups (Caucasians, Afro-Brazilians and Asians in the north of Parana State. METHODS: A study was carried out of 3978 voluntary bone marrow donors registered in the Brazilian National Bone Marrow Donor Registry and typed for the HLA-A, B and DRB1 (low resolution loci. The alleles were characterized by the polymerase chain reaction sequence-specific oligonucleotides method using the LabType SSO kit (One Lambda, CA, USA. The ARLEQUIN v.3.11 computer program was used to calculate allele and haplotype frequencies. Results: The most common alleles found in Caucasians were HLA-A*02, 24, 01; HLA-B*35, 44, 51; DRB1*11, 13, 07; for Afro-Brazilians they were HLA-A*02, 03, 30; HLA-B*35, 15, 44; DRB1*13, 11, 03; and for Asians they were: HLA-A*24, 02, 26; HLA-B*40, 51, 52; DRB1*04, 15, 09. The most common haplotype combinations were: HLA-A*01, B*08, DRB1*03 and HLA-A*29, B*44, DRB1*07 for Caucasians; HLA-A*29, B*44, DRB1*07 and HLA-A*01, B*08 and DRB1*03 for Afro-Brazilians; and HLA-A*24, B*52, DRB1*15 and HLA-A*24, B*40 and DRB1*09 for Asians. CONCLUSIONS: There is a need to target and expand bone marrow donor campaigns in the north of Parana State. The data of this study may be used as a reference by the Instituto Nacional de Cancer/Brazilian National Bone Marrow Donor Registry to evaluate the immunogenetic profile of populations in specific regions and in the selection of bone marrow donors.
Bardi, Marlene Silva; Jarduli, Luciana Ribeiro; Jorge, Adylson Justino; Camargo, Rossana Batista Oliveira Godoy; Carneiro, Fernando Pagotto; Gelinski, Jair Roberto; Silva, Roseclei Assunção Feliciano; Lavado, Edson Lopes
2012-01-01
Knowledge of allele and haplotype frequencies of the human leukocyte antigen (HLA) system is important in the search for unrelated bone marrow donors. The Brazilian population is very heterogeneous and the HLA system is highly informative of populations because of the high level of polymorphisms. The aim of this study was to characterize the immunogenetic profile of ethnic groups (Caucasians, Afro-Brazilians and Asians) in the north of Parana State. A study was carried out of 3978 voluntary bone marrow donors registered in the Brazilian National Bone Marrow Donor Registry and typed for the HLA-A, B and DRB1 (low resolution) loci. The alleles were characterized by the polymerase chain reaction sequence-specific oligonucleotides method using the LabType SSO kit (One Lambda, CA, USA). The ARLEQUIN v.3.11 computer program was used to calculate allele and haplotype frequencies The most common alleles found in Caucasians were HLA-A*02, 24, 01; HLA-B*35, 44, 51; DRB1*11, 13, 07; for Afro-Brazilians they were HLA-A*02, 03, 30; HLA-B*35, 15, 44; DRB1*13, 11, 03; and for Asians they were: HLA-A*24, 02, 26; HLA-B*40, 51, 52; DRB1*04, 15, 09. The most common haplotype combinations were: HLA-A*01, B*08, DRB1*03 and HLA-A*29, B*44, DRB1*07 for Caucasians; HLA-A*29, B*44, DRB1*07 and HLA-A*01, B*08 and DRB1*03 for Afro-Brazilians; and HLA-A*24, B*52, DRB1*15 and HLA-A*24, B*40 and DRB1*09 for Asians. There is a need to target and expand bone marrow donor campaigns in the north of Parana State. The data of this study may be used as a reference by the Instituto Nacional de Cancer/Brazilian National Bone Marrow Donor Registry to evaluate the immunogenetic profile of populations in specific regions and in the selection of bone marrow donors.
Henryon, Mark; Jokumsen, Alfred; Berg, Peer
2002-01-01
The objective of this study was to test that additive genetic (co)variation for survival, growth rate, feed conversion efficiency, and resistance to viral haemorrhagic septicaemia (VHS) exists within a farmed population of rainbow trout. Thirty sires and 30 dams were mated by a partly factorial...... the predicted breeding values for VHS resistance and the predicted breeding values for the body weights, body length, and feed conversion efficiencies. These results demonstrate that additive genetic (co)variation for growth rate, feed conversion efficiency, and VHS resistance does exist within the farmed...
Marwan Amin Kutbi
2013-01-01
Full Text Available We introduce two new concepts of weakly relaxed η-α monotone mappings and weakly relaxed η-α semimonotone mappings. Using the KKM technique, the existence of solutions for variational-like problems with weakly relaxed η-α monotone mapping in reflexive Banach spaces is established. Also, we obtain the existence of solution for variational-like problems with weakly relaxed η-α semimonotone mappings in arbitrary Banach spaces by using the Kakutani-Fan-Glicksberg fixed-point theorem.
Discovery and genotyping of existing and induced DNA sequence variation in potato
Uitdewilligen, J.G.A.M.L.
2012-01-01
In this thesis natural and induced DNA sequence diversity in potato (Solanum tuberosum) for use in marker-trait analysis and potato breeding is assessed. The study addresses the challenges of reliable, high-throughput identification and genotyping of sequence variants in existing tetraploid potato c
Yonghan Choi
2014-01-01
Full Text Available An adjoint sensitivity-based data assimilation (ASDA method is proposed and applied to a heavy rainfall case over the Korean Peninsula. The heavy rainfall case, which occurred on 26 July 2006, caused torrential rainfall over the central part of the Korean Peninsula. The mesoscale convective system (MCS related to the heavy rainfall was classified as training line/adjoining stratiform (TL/AS-type for the earlier period, and back building (BB-type for the later period. In the ASDA method, an adjoint model is run backwards with forecast-error gradient as input, and the adjoint sensitivity of the forecast error to the initial condition is scaled by an optimal scaling factor. The optimal scaling factor is determined by minimising the observational cost function of the four-dimensional variational (4D-Var method, and the scaled sensitivity is added to the original first guess. Finally, the observations at the analysis time are assimilated using a 3D-Var method with the improved first guess. The simulated rainfall distribution is shifted northeastward compared to the observations when no radar data are assimilated or when radar data are assimilated using the 3D-Var method. The rainfall forecasts are improved when radar data are assimilated using the 4D-Var or ASDA method. Simulated atmospheric fields such as horizontal winds, temperature, and water vapour mixing ratio are also improved via the 4D-Var or ASDA method. Due to the improvement in the analysis, subsequent forecasts appropriately simulate the observed features of the TL/AS- and BB-type MCSs and the corresponding heavy rainfall. The computational cost associated with the ASDA method is significantly lower than that of the 4D-Var method.
Wound classification in pediatric general surgery: significant variation exists among providers.
Snyder, Rebecca A; Johnson, Lisa; Tice, Jamie; Wingo, Tammy; Williams, Dana; Wang, Li; Blakely, Martin L
2013-11-01
Risk-adjusted rates of surgical site infections (SSI) are used as a quality metric to facilitate improvement within a hospital system and allow comparison across institutions. The NSQIP-Pediatric, among others, uses surgical wound classification as a variable in models designed to predict risk-adjusted postoperative morbidity, including SSI rates. The purpose of this study was to measure the level of agreement in wound classification assignment among 3 providers: surgeons, operating room (OR) nurses, and NSQIP surgical clinical reviewers (SCR). An analysis was performed of pediatric general surgery operations from 2010 to 2011. Wound classification was assigned at the time of operation by the OR nurse and surgeon, and by the NSQIP SCR postoperatively, according to NSQIP methodology. Disagreement was defined as any discrepancy in classification among the 3 providers, and the level of agreement was determined using the kappa statistic. For the 374 procedures reviewed, there was an overall disagreement of 48% among all providers, kappa 0.48 (95% CI 0.43 to 0.53). When comparing wound classification by surgeon and NSQIP SCR, 23% of cases were in disagreement, kappa 0.74 (95% CI 0.68 to 0.78). Disagreement between OR nurse and either surgeon or NSQIP SCR was higher: 38%, kappa 0.45 (95% CI 0.38 to 0.53) and 40%, kappa 0.44 (95% CI 0.37 to 0.51). Fundoplication, appendectomy, and cholecystectomy demonstrated the highest overall disagreement (73%, 71%, and 60%, respectively). There is significant variation in assigning surgical wound classification among health care providers. For future SSI comparative analyses, it will be critical to improve uniformity and understanding of wound class assignment among providers and institutions. Copyright © 2013 American College of Surgeons. Published by Elsevier Inc. All rights reserved.
Spatial variation of five co-existing siluriformes in an atlantic rain forest drainage
Rosana Mazzoni
2009-02-01
Full Text Available Five species of Siluriformes were registered in the Ubatiba system. Pimelodella lateristriga was the dominant one, followed by Hypostomus gr. punctatus, Rineloricaria sp., Callichthys callichthys and Rhamdia sp. Simple correlation analysis between species density and habitat parameters indicated that hydrology explained density patterns of four species. Pimelodella densities were negatively correlated with pools, Callichthys and Hypostomus densities were positively correlated with runs and Rhamdia densities were positively correlated with riffles; Rineloricaria densities did not respond to any hydrological parameter. Substrata were an important factor to all species, but specific preferences were observed. Marginal vegetation was positively correlated only to Pimelodella densities. Sorensen dissimilarity analysis indicated that site groups, based on both species composition and habitat parameters, were very similar and corroborated the correlation analysis suggesting that Siluriformes composition should be explained by many habitat parameters. Analysis of co-variation of species densities at each sampling occasion showed to be statistically similar in at least all (100% analysed cases indicating that Siluriformes composition was strongly persistent in time.Cinco espécies de Siluriformes foram registradas no sistema fluvial do rio Ubatiba, Pimelodella lateristriga foi a espécie dominante seguida de Hypostomus gr. punctatus, Rineloricaria sp., Callichthys callichthys e Rhamdia sp. Análises de correlação simples entre as densidades das espécies e as variáveis de hábitat indicaram que a hidrologia explicou os padrões de densidade de quatro espécies; as densidades de Pimelodella foram negativamente correlacionadas com a presença de poças, as densidades de Callichthys e Hypostomus foram positivamente correlacionadas com os rápidos e as densidades de Rhamdia foram positivamente correlacionadas com as corredeiras; as densidades de
Wang, F; He, J; Chen, S; Qin, F; Dai, B; Zhang, W; Zhu, F M; Lv, H J
2014-02-01
Umbilical cord blood (UCB) is a widely accepted source of progenitor cells, and now, many cord blood banks were established. Here, we analysed the HLA-A, HLA-B and HLA-DRB1 allele and haplotype frequencies, HLA matching possibilities for searching potential donors and outcome of UCB transplantations in Zhejiang cord blood bank of China. A total of 6384 UCB units were characterized for 17 HLA-A, 30 HLA-B and 13 HLA-DRB1 alleles at the first field resolution level. Additionally, B*14, B*15 and B*40 were typed to the second field level. A total of 1372 distinct A-B-DRB1 haplotypes were identified. The frequencies of 7 haplotypes were more than 1%, and 439 haplotypes were blood bank of Zhejiang province. These data can help to select potential UCB donors for transplantation and used to assess the scale of new cord blood banking endeavours.
Wang Jun
2009-03-01
Full Text Available Abstract Background A small region of about 70 kb on human chromosome 19q13.3 encompasses 4 genes of which 3, ERCC1, ERCC2, and PPP1R13L (aka RAI are related to DNA repair and cell survival, and one, CD3EAP, aka ASE1, may be related to cell proliferation. The whole region seems related to the cellular response to external damaging agents and markers in it are associated with risk of several cancers. Methods We downloaded the genotypes of all markers typed in the 19q13.3 region in the HapMap populations of European, Asian and African descent and inferred haplotypes. We combined the European HapMap individuals with a Danish breast cancer case-control data set and inferred the association between HapMap haplotypes and disease risk. Results We found that the susceptibility haplotype in our European sample had increased from 2 to 50 percent very recently in the European population, and to almost the same extent in the Asian population. The cause of this increase is unknown. The maximal proportion of overall genetic variation due to differences between groups for Europeans versus Africans and Europeans versus Asians (the Fst value closely matched the putative location of the susceptibility variant as judged from haplotype-based association mapping. Conclusion The combined observation that a common haplotype causing an increased risk of cancer in Europeans and a high differentiation between human populations is highly unusual and suggests a causal relationship with a recent increase in Europeans caused either by genetic drift overruling selection against the susceptibility variant or a positive selection for the same haplotype. The data does not allow us to distinguish between these two scenarios. The analysis suggests that the region is not involved in cancer risk in Africans and that the susceptibility variants may be more finely mapped in Asian populations.
何琼; 刘长晖; 王慧君; 刘超
2011-01-01
[Objective]To develop the method typing SNPs of mitochondrial DNA with fluorescence labeling and apply to the forensic science practice.[Methods]Eighteen SNPs selected from mtDNA (16 SNPs in the coding region and 2 SNPs in the control region) were studied the rules of of primers’ design multiplex system and multiplex sequencing system then carried out capillary electrophoresis.[Results]The 18-plex mitochondrial DNA SNPs minisequencing reaction was developed and the data of SNP haplotype frequency in Guangdong Han population was obtained.[Conclusion]The multiplex amplication of mitochondrial DNA SNPs was established and showed that the system has a favorable prospective in the forensic science.%[目的]利用荧光标记--单碱基延伸技术建立线粒体DNA SNPs高通量检测体系并应用于法医学检案.[方法]从线粒体DNA上选择18个SNPs(16个位于编码区和2个控制区)位点,自行设计PCR引物和单碱基延伸引物并结合毛细管电泳,实现对线粒体多个SNPs位点的高通量检测.[结果]建立了18个线粒体DNA SNPs复合检测体系,并调查这18个SNPs位点在广东地区汉族人群的单倍型频率.[结论]所建立的线粒体SNPs复合检测体系,在法医学应用中具有良好的应用前景.
Karlovitz, L. A.; Atluri, S. N.; Xue, W.-M.
1985-01-01
The extensions of Reissner's two-field (stress and displacement) principle to the cases wherein the displacement field is discontinuous and/or the stress field results in unreciprocated tractions, at a finite number of surfaces ('interelement boundaries') in a domain (as, for instance, when the domain is discretized into finite elements), is considered. The conditions for the existence, uniqueness, and stability of mixed-hybrid finite element solutions based on such discontinuous fields, are summarized. The reduction of these global conditions to local ('element') level, and the attendant conditions on the ranks of element matrices, are discussed. Two examples of stable, invariant, least-order elements - a four-node square planar element and an eight-node cubic element - are discussed in detail.
Izmaylov, D M; Obukhova, L K
2003-05-01
Survival of Drosophila melanogaster was estimated in 128 successive generations for 5 years. The resultant 116 samples (58 for females and 58 for males) containing series of individual values of life span (LS; 50-90 values in each series) were analyzed. Each of 58 pairs of samples belonged to a definite generation in a continuous succession where every next generation was an offspring of the preceding one. In total, 10180 Drosophila flies (5100 females and 5080 males) were studied. The mean life span (MLS) was found to be considerably heterogeneous in the series of generations: in many pairs of consecutive generations, MLSs significantly differed within two errors of the mean (Psuccessive generations of D. melanogaster. Highly significant (Psuccessive generations of the same population, with the proportions of individuals with low and high LSs remaining about the same irrespective of the MLS. It was demonstrated with the use of mathematical simulation that the MLS changes in successive generations may be regarded as an oscillatory process and described as a sum of several (three to five) harmonic components. The calculated determination coefficients were high (93.51 and 88.93% for females and males, respectively). This indicates that the mathematical model used for simulation adequately described the observed variations in MLS. The results are discussed in terms of population gerontology and the problem of geroprotector effectiveness.
Hamilton City Board of Education (Ontario).
Suggestions for studying the topic of variation of individuals and objects (balls) to help develop elementary school students' measurement, comparison, classification, evaluation, and data collection and recording skills are made. General suggestions of variables that can be investigated are made for the study of human variation. Twelve specific…
Ryan, A W; Thornton, J M; Brophy, K; Daly, J S; McLoughlin, R M; O'Morain, C; Abuzakouk, M; Kennedy, N P; Stevens, F M; Feighery, C; Kelleher, D; McManus, R
2005-02-01
Genetic predisposition to coeliac disease (CD) is determined primarily by alleles at the HLA-DQB locus, and evidence exists implicating other major histocompatibility complex-linked genes (6p21) and the CTLA4 locus on chromosome 2q33. In addition, extensive family studies have provided strong, reproducible evidence for a susceptibility locus on chromosome 5q (CELIAC2). However, the gene responsible has not been identified. We have assayed genetic variation at the IL4, IL5, IL9, IL13, IL17B and NR3C1 (GR) loci, all of which are present on chromosome 5q and have potential or demonstrated involvement in autoimmune and/or inflammatory disease, in a sample of 409 CD cases and 355 controls. Thirteen single nucleotide polymorphisms were chosen on the basis of functional relevance, prior disease association and, where possible, prior knowledge of the haplotype variation present in European populations. There were no statistically significant allele or haplotype frequency differences between cases and controls. Therefore, these results provide no evidence that these loci are associated with CD in this sample population.
Genetic Variation of Host Populations of Liriomyza sativae Blanchard
WANG Li-ping; DU Yu-zhou; HE Ya-ting; ZHENG Fu-shan; LU Zi-qiang
2008-01-01
In this study, partial sequences of the mitochondrial cytochrome oxidase subunit Ⅰ (mtDNA-COI) gene and the ribosomal internal transcribed spacer 1 (rDNA-ITS1) gene, isolated from five artificial populations of Liriomyza sativae (Diptera:Agromyzidae), were sequenced and compared, to analyze their genetic variation. Analysis of the mtDNA-CO1 gene showed that a low genetic variation was detected among the five populations and only five variable sites were found in the nucleotide sequences. Most of the observed variations that occurred within the populations were because of nucleotide transitions, whereas, the interpopulation variation was because of the differences in haplotype frequencies occurring among the host populations. Analysis of the rDNA-ITS1 gene revealed a small diversity in the five host populations. The trend of genetic differentiation in the host populations was consistent with the preference of L. sativae to the plant hosts.
Wu, Tsung-Jung; Shamsaddini, Amirhossein; Pan, Yang; Smith, Krista; Crichton, Daniel J; Simonyan, Vahan; Mazumder, Raja
2014-01-01
Years of sequence feature curation by UniProtKB/Swiss-Prot, PIR-PSD, NCBI-CDD, RefSeq and other database biocurators has led to a rich repository of information on functional sites of genes and proteins. This information along with variation-related annotation can be used to scan human short sequence reads from next-generation sequencing (NGS) pipelines for presence of non-synonymous single-nucleotide variations (nsSNVs) that affect functional sites. This and similar workflows are becoming more important because thousands of NGS data sets are being made available through projects such as The Cancer Genome Atlas (TCGA), and researchers want to evaluate their biomarkers in genomic data. BioMuta, an integrated sequence feature database, provides a framework for automated and manual curation and integration of cancer-related sequence features so that they can be used in NGS analysis pipelines. Sequence feature information in BioMuta is collected from the Catalogue of Somatic Mutations in Cancer (COSMIC), ClinVar, UniProtKB and through biocuration of information available from publications. Additionally, nsSNVs identified through automated analysis of NGS data from TCGA are also included in the database. Because of the petabytes of data and information present in NGS primary repositories, a platform HIVE (High-performance Integrated Virtual Environment) for storing, analyzing, computing and curating NGS data and associated metadata has been developed. Using HIVE, 31 979 nsSNVs were identified in TCGA-derived NGS data from breast cancer patients. All variations identified through this process are stored in a Curated Short Read archive, and the nsSNVs from the tumor samples are included in BioMuta. Currently, BioMuta has 26 cancer types with 13 896 small-scale and 308 986 large-scale study-derived variations. Integration of variation data allows identifications of novel or common nsSNVs that can be prioritized in validation studies. Database URL: BioMuta: http
Li Xiao-Jing
2008-01-01
This paper studies a time delay equation for sea-air oscillator model. The existence and asymptotic estimates of periodic solutions of corresponding problem are obtained by employing the technique of upper and lower solution, and by using the continuation theorem of coincidence degree theory.
Rukmini Dey
2001-11-01
Given a smooth function < 0 we prove a result by Berger, Kazhdan and others that in every conformal class there exists a metric which attains this function as its Gaussian curvature for a compact Riemann surface of genus > 1. We do so by minimizing an appropriate functional using elementary analysis. In particular for a negative constant, this provides an elementary proof of the uniformization theorem for compact Riemann surfaces of genus > 1.
Haplotypes frequencies of CYP2B6 in Malaysia
N Musa
2012-01-01
Full Text Available Background: Drugs with complex pharmacology are used in the management of drug use disorder (DUD and HIV/AIDS in Malaysia and in parts of South-East Asia. Their multiethnic populations suggest complexity due to the genetic polymorphism, such as CYP2B6 that metabolizes methadone and anti-retroviral. Aims: Our aim was to explore the genetic polymorphism of CYP2B6 among Malays, Chinese, Indians, and opiate-dependent individuals in Malaysia. Settings and Design: The study utilized DNA from our previous studies on CYPs and new recruitments from opiate-dependent individuals. Materials and Methods: For the new recruitment, after obtaining consent and baseline demography, 5 ml blood was obtained from patients attending methadone maintenance therapy (MMT Clinics. Genomic DNA was extracted using standard methods. 10 nucleotide changes associated with CYP2B6FNx0110, CYP2B6FNx012, CYP2B6FNx0117, CYP2B6FNx0111, CYP2B6FNx018, CYP2B6FNx0114, CYP2B6FNx019, CYP2B6FNx014, CYP2B6FNx016, CYP2B6FNx0127, and CYP2B6FNx0120 were determined using multiplex nested allele-specific PCR. Statistical Analysis: Descriptive statistics were used to summarize demographic data. Differences in allele frequencies between populations were tested using Chi-squared test and were corrected using the Bonferroni test. Results: CYP2B6 polymorphism in Malaysia is variable with trends that suggest an ethnic difference. Reduced activity CYP2B6FNx016 occurred in 13% to 26% among Malays, Chinese, Indians and opiate-dependent individuals. Another ′reduced activity′, CYP2B6FNx012 allele, was found at much lower percentages in the groups. Conclusions: The relative commonness of reduced-activity CYP2B6 alleles in our study called for attention in terms of dosage requirements for MMT and ARV in Malaysia. It also implored follow-up association studies to determine its relevance and consequences in personalized medicine for drug use disorder and HIV/AIDS.
Haplotypes frequencies of CYP2B6 in Malaysia.
Musa, N; Zulkafli, M I; Talib, N; Mohamad, N; Fauzi, H; Ismail, R
2012-01-01
Drugs with complex pharmacology are used in the management of drug use disorder (DUD) and HIV/AIDS in Malaysia and in parts of South-East Asia. Their multiethnic populations suggest complexity due to the genetic polymorphism, such as CYP2B6 that metabolizes methadone and anti-retroviral. Our aim was to explore the genetic polymorphism of CYP2B6 among Malays, Chinese, Indians, and opiate-dependent individuals in Malaysia. The study utilized DNA from our previous studies on CYPs and new recruitments from opiate-dependent individuals. For the new recruitment, after obtaining consent and baseline demography, 5 ml blood was obtained from patients attending methadone maintenance therapy (MMT) Clinics. Genomic DNA was extracted using standard methods. 10 nucleotide changes associated with CYP2B6*10, CYP2B6*2, CYP2B6*17, CYP2B6*11, CYP2B6*8, CYP2B6*14, CYP2B6*9, CYP2B6*4, CYP2B6*6, CYP2B6*27, and CYP2B6*20 were determined using multiplex nested allele-specific PCR. Descriptive statistics were used to summarize demographic data. Differences in allele frequencies between populations were tested using Chi-squared test and were corrected using the Bonferroni test. CYP2B6 polymorphism in Malaysia is variable with trends that suggest an ethnic difference. Reduced activity CYP2B6*6 occurred in 13% to 26% among Malays, Chinese, Indians and opiate-dependent individuals. Another 'reduced activity', CYP2B6*2 allele, was found at much lower percentages in the groups. The relative commonness of reduced-activity CYP2B6 alleles in our study called for attention in terms of dosage requirements for MMT and ARV in Malaysia. It also implored follow-up association studies to determine its relevance and consequences in personalized medicine for drug use disorder and HIV/AIDS.
赵凯平; 王红
2011-01-01
Objective To provide scientific basis of single nucleotide polymorphism (SNPs) determination for ROR2 gene related etiologic studies in Han Chinese in Beijing (CHB) and Utah residents with Northern and Western European ancestry from the CEPH collection (CEU) populations. Methods SNPs in the ROR2 gene of CHB and CEU were analyzed and compared for minor allele frequencies (MAF), hap-lotype blocks and haplotype frequencies by Haploview program. SNPs were screened for eligibility with the quality control criteria of genotyping call rate>80% , HWE test P>0. 01, gender difference P>0. 05 and MAF>0. 01. Tag SNPs were determined with the criteria of r2 ≥0. 8 and LOD≥3 for pairwised eligible SNPs. Common Tag SNPs in the populations of CHB and CEU were either directly analyzed by Haploview program or calculated by SPSS13. 0 for those highly related independent tag SNPs. Results Among 396 genotyped SNPs in CHB and CEU, 102 (25. 8%) were monotonic and common in both populations. The proportions of common eligible SNPs were 78. 3% (206/263) and 75. 2% (206/274) for the populations of CHB and CEU, respectively. Most common eligible SNPs had common minor alleles (189/206, 91. 7%) and of which, 39. 2% had MAF ratio difference<20%. Among 18 and 14 haplotype blocks identified in 206 common eligible SNPs for CHB and CEU, one haplotype block each was independent, three haplotype blocks were common and the remaining 14 haplotype blocks in CHB were overlapped with the 10 haplotype blocks in CEU. A total of 31 common tag SNPs were determined for the populations of CHB (40.3%, 31/77) and CEU (44.9%, 31/69). Conclusion SNPs in ROR2 gene had common and unique features in terms of allele, MAF, haplotype blocks and haplotype frequencies for CHB and CEU populations.%目的 分析比较北京汉族(CHB)和西北欧洲后裔人群(CEU) ROR2基因单核苷酸多态性(SNPs)和单体域的特征,为两人群病因学研究SNPs的确定和分析提供依据.方法
Burnett, Scott E; Stojanowski, Christopher M; Mahakkanukrauh, Pasuk
2015-03-01
Carpal bone bipartition is a developmental variant resulting in the division of a normally singular carpal into two distinct segments. Cases involving the scaphoid are best known, though many other carpals can be affected, including the trapezoid. Six new examples of bipartite trapezoids, identified in African and Asian anatomical and archeological samples, are reported here and compared with the eight previously known. While the site of bipartition is consistent, the resulting segments exhibit variability in their articulations with neighboring carpals. Five of the six affected trapezoids were identified in African or African-derived samples, yielding a significantly higher frequency (0.323%) of bipartite trapezoid than seen in anatomical or archeological series of European origin. Bilateral bipartite trapezoids in archeological remains from the Mid Holocene site of Gobero (Niger) are potentially the oldest bipartite carpals yet identified in humans. Their discovery may indicate that trapezoid bipartition is a condition that has been present in African populations since prehistoric times, though more data are needed. Because bipartite carpals may be symptomatic and can occur as part of syndromes, the significant population variation in frequency identified here has potential utility in both anatomical and clinical contexts. However, a comparison of the morphological appearance of bipartite trapezoids with the suggested criteria for bipartite scaphoid diagnosis indicates that these criteria are not equally applicable to other carpals. Fortunately, due to the rarity of fracture, identification of the bipartite trapezoid and separating it from pathological conditions is considerably easier than diagnosing a bipartite scaphoid.
王红; 赵凯平
2011-01-01
Objective:To provide basis for single nucleotide polymorphisms (SNPs) determination and analysis for R0R2 genes related etiologic studies in Chinese Hans in Beijing (CHB) and Yoruban in Iba-dan in Nigeria ( YRI) populations. Methods: SNPs in R0R2 gene were analyzed and compared for minor allele frequencies (MAFs) , haplotype frequencies, linkage disequilibrium patterns, and tag SNPs using CHB and YRI data from HapMap by Haploview 4. 2 program. SNPs were screened for eligibility using quality control criteria of genotyping call rate ＞80% , Hardy-Weinberg equilibrium test P ＞0.01, gender difference P＞0. 05 and MAF ＞0. 01. Tag SNPs were determined under the criteria for r2≥0. 8 and logarithm of the odds radio ≥3 in pairwise eligible SNPs and compared between the CHB and YRI samples. Common Tag SNPs for CHB and YRI were reported by Haploview program directly or identified a-mong SNPs which were higly related to Haploview program directly reported tag SNPs by SPSS 13. 0. Results: Among the 404 and 403 SNPs genotyped in ROR2 genes in the CHB and YRI samples released by HapMap project, there were five SNPs located at exon 6 or 9 where changes of alleles for rs 1076112 and rs 10820900 caused missense mutation. Among the 394 SNPs genotyped in both the populations, a total number of 101 (25. 6% ) SNPs were monotonic among which 66 (65. 3% ) SNPs were common in both CHB and YRI. The rs 1135150 and rs2230577 which were monotonic in YRI and eligible in CHB located at exon 9. Nine ungenotyped SNPs in CHB were all eligible in YRI, and 6 out of 10 ungenotyped SNPs in YRI were eligible in CHB. The proportion of common SNPs (214) were 81.4% and 73. 3% in eligible CHB (263) and YRI (292) SNPs where 177 (82. 7% ) had the same minor alleles and 30 SNPs also had MAF difference ratios＜20% that represented 11.4% and 10.3% of the total number of eligible SNPs in CHB and YRI respectively. Among the 18 and 26 haplotype blocks formed in 214 common eligible SNPs, two independent
李宝麟; 王佳
2013-01-01
The Henstock-Kurzweil integral includes the Newton,Riemann and Lebesgue integrals.The existence theorem of bounded variation solutions for a general class of impulsive retarded function differential equations is established by using the Henstock-Kurzweil integral and the Shauder fixed-point theorem.This generalizes the existence theorem from the Lebesgue setting to the Henstock-Kurzweil setting.%Henstock-Kurzweil积分一般包括牛顿、黎曼和勒贝格积分.借助Henstock-Kurzweil积分和Schauder 不动点定理建立了一类滞后脉冲微分方程有界变差解存在性定理并加以证明,所得结果将存在性定理从Lebesgue 积分意义下推广到Henstock-Kurzweil积分意义下.
陈季林
2008-01-01
对如下的阻尼振动问题:{ü(t) +g(t) (u) (t) = ▽F(t,u(t) ),a.e.t∈[0,T],u(0) -u(T) = (u) (0) - (u) (T) =0.此处,T＞0,g∈L1(0,T,;R),G(t)=∫1 0 g(s)ds,G(T)=0,F:[0,T]×RN→R,给出其变分原理,并得到2个周期解的存在性定理.%In the present paper, we research the following damped vibration problemu{ü(t) +g(t) (u) (t) = ▽F(t,u(t) ),a.e.t∈[0,T],u(0) -u(T) = (u) (0) - (u) (T) =0 where T＞0,g∈L1(0,T,;R),G(t)=∫1 0 g(s)ds,G(T)=0,F:[0,T]×RN→R. The variational principle is given, and two existence theorems of periodic solutions are obtained.
Osinov, A G; Miuge, N S
2008-12-01
Analysis of a 551-bp segment of the mitochondrial DNA control region in 23 individuals from nine populations of Dolly Varden from Sakhalin and three individuals from the Shikaribetsu Lake (Hokkaido) revealed the presence of seven haplotypes of southern form, along with one haplotype of northern form of Dolly Varden. All seven haplotypes of southern Dolly Varden were earlier described in the populations from Hokkaido. Nested analysis of molecular variance (AMOVA) based on the haplotype frequencies, performed using literature data, suggested that, during the glacial epoch, there were three regional population groups of Dolly Varden (from eastern and western coasts of Sakhalin, and from Southern Primorye). Population groups from Sakhalin and Primorye were clearly separated. The differences between two Sakhalin population groups in the mtDNA haplotype frequencies were not statistically significant. However, relative to the earlier obtained data on microsatellite loci, these differences were statistically significant. For the populations of Sakhalin Dolly Varden, the data on mitochondrial and microsatellite DNA variation supplement each other.
Existence and non-existence results for the SU(3) singular Toda system on compact surfaces
Battaglia, Luca; Malchiodi, Andrea
2015-01-01
We consider the SU(3) Toda system on a compact surface. We give both existence and non-existence results under some conditions on the parameters. Existence results are obtained using variational methods, which involve a geometric inequality of new type; non-existence results are obtained using blow-up analysis and localized Pohozaev identities.
Requirements for existing buildings
Thomsen, Kirsten Engelund; Wittchen, Kim Bjarne
2012-01-01
This report collects energy performance requirements for existing buildings in European member states by June 2012.......This report collects energy performance requirements for existing buildings in European member states by June 2012....
Requirements for existing buildings
Thomsen, Kirsten Engelund; Wittchen, Kim Bjarne
2012-01-01
This report collects energy performance requirements for existing buildings in European member states by June 2012.......This report collects energy performance requirements for existing buildings in European member states by June 2012....
Tachi, Susumu; Arai, Hirohiko; Maeda, Taro
1989-01-01
Tele-existence is an advanced type of teleoperation system that enables a human operator at the controls to perform remote manipulation tasks dexterously with the feeling that he or she exists in the remote anthropomorphic robot in the remote environment. The concept of a tele-existence is presented, the principle of the tele-existence display method is explained, some of the prototype systems are described, and its space application is discussed.
Genetic variations of miR-541 exist in type 1 diabetes children%微小核糖核酸miR-541在1型糖尿病中的遗传变异研究
韩蓓; 石星; 孙雯; 彭泉; 高文涛
2010-01-01
目的 对1型糖尿病(T1DM)儿童微小RNA miR-541基因进行筛查,以了解T1DM儿童该基因变异情况.方法 选择2006年1月至2009年8月在南京医科大学附属南京儿童医院内分泌科确诊的T1DM患儿69例和46名健康对照儿,用PCR扩增结合直接测序方法,对miR-541基因-1084～+167区域的遗传变异进行筛选;用限制性片段长度多态性(RFLP)方法对筛选出的特定变异位点检测,并用RNA二级结构分析软件RNAfold分析.结果 发现1个单核苷酸多态性(SNP)数据库报道的SNP(rs12893725),以及新发现3个未报道的基因变异,其中-284杂合C→T、-569杂合G→A为SNP在健康对照和糖尿病儿童均存在,其发生率、发病年龄和发病时糖化血红蛋白在患者和对照组中无显著差异.因-404杂合G→T基因变异仅在3例糖尿病患者发现,随后采用RFLP对该位点变异在另外105名健康对照者进行筛查,发现健康对照者和T1DM儿童的-404杂合D→T基因变异发生率分别为1/(46+105)和3/69,是一种少见SNP,RNAfold分析发现-404G→T基因变异显著影响miR-541前体二级结构,可能导致其处理和表达差异.结论 发现miR-541基因在T1DM存在遗传变异,其中-404杂合G→T是可能的糖尿病相关变异.%Objective To screen whether microRNA miR-541 has T1DM associated genetic variation. Methods From January 2006 to August 2009,sixty-nine type 1 diabetes children (T1DM group) and 46 healthy volunteers (control group) were selected in Nanjing Children Hospital of Nanjing Medical University. PCR amplification and direct sequencing were used to screen genetic variations within -1084 ~ + 167 region of pre-miR-541 gene. RFLP and RNA fold were used for the candidate genetic variation. Results One SNP database reported SNP (rs 12893725 ) and three unreported genetic variation were found. Two of them ( - 284 heterogeneous C→T and - 569 heterogeneous G→A) were found in both diabetes patients and healthy volunteers, there
Akers, David
1990-10-01
A status report is presented on the existence of quarks carrying the Dirac unit of magnetic charge g = (137/2) e. The Paschen-Back effect in dyonium is discussed. From the dyonium model, Akers predicted the existence of a new η meson at 1814 MeV with I G(JPC) = 0+(0-+). Experimental evidence now confirms the existence of the meson resonance.
Reutilizing Existing Library Space.
Davis, Marlys Cresap
1987-01-01
This discussion of the reutilization of existing library space reviews the decision process and considerations for implementation. Two case studies of small public libraries which reassigned space to better use are provided, including floor plans. (1 reference) (MES)
Heinrich, Stuart
2012-01-01
Despite the success of physics in formulating mathematical theories that can predict the outcome of experiments, we have made remarkably little progress towards answering some of the most basic questions about our existence, such as: why does the universe exist? Why is the universe apparently fine-tuned to be able to support life? Why are the laws of physics so elegant? Why do we have three dimensions of space and one of time? How is it that the universe can be non-local and non-causal at the quantum scale, and why is there quantum randomness? In this paper, it is shown that all of these questions are answered if existence is relative, and moreover, it seems that we are logically bound to accept it.
This elusive objective existence
Mohrhoff, U
2004-01-01
Zurek's existential interpretation of quantum mechanics suffers from three classical prejudices, including the belief that space and time are intrinsically and infinitely differentiated. They compel him to relativize the concept of objective existence in two ways. The elimination of these prejudices makes it possible to recognize the quantum formalism's ontological implications - the relative and contingent reality of spatiotemporal distinctions and the extrinsic and finite spatiotemporal differentiation of the physical world - which in turn makes it possible to arrive at an unqualified objective existence. Contrary to a widespread misconception, viewing the quantum formalism as being fundamentally a probability algorithm does not imply that quantum mechanics is concerned with states of knowledge rather than states of Nature. On the contrary, it makes possible a complete and strongly objective description of the physical world that requires no reference to observers. What objectively exists, in a sense that r...
Relativity, Dimensionality, and Existence
Petkov, Vesselin
A 100 years have passed since the advent of special relativity and 2008 will mark another important to all relativists anniversary - 100 years since Minkowski gave his talk "Space and Time" on September 21, 1908 in which he proposed the unifi- cation of space and time into an inseparable entity - space-time. Although special relativity has been an enormously successful physical theory no progress has been made in clarifying the question of existence of the objects represented by two of its basic concepts - space-time and world lines (or worldtubes in the case of extended bodies). The major reason for this failure appears to be the physicists' tradition to call such questions of existence philosophical. This tradition, however, is not quite consistent. In Newtonian mechanics physicists believe that they describe real objects whenever they talk about particles - one of the basic concepts of Newtonian physics. The situation is the same in quantum physics - no one questions the existence of electrons, protons, etc. Then why should the question of existence of worldtubes (representing particles in relativity) be regarded as a philosophical question?
1985-01-01
envisionment ) produced by GIZMO . ? In the envisionment , I s indicates the set of quantity—conditioned individuals that exists during a situa- tion... envisionment step by step . In START, the initial state, GIZMO deduces that heat flow occurs, since there is assumed to be a temperature difference between the...stov e GIZMO implements the basic operations of qualitative process theory, including an envisioner for makin g predictions and a program for
Hermeneutics as Embodied Existence
Marja Schuster RN, PhD
2013-02-01
Full Text Available This article explores the possibilities and limits of a hermeneutic way of being in the world, more specifically being a researcher as a part of human, embodied existence. Understanding existence as embodied highlights the subjectivity of a researcher. For a hermeneutic researcher this subjectivity is both a precondition for interpretation and something that might endanger the scientific endeavour. In this article, I examine the possibilities of combining Hans-Georg Gadamer's empathetic hermeneutics with Paul Ricoeur's critical hermeneutics as a means of both recognizing and, to some extent, controlling my subjectivity in the research process. With Gabriel Marcel I also argue for hermeneutics as an embodied experience. This is exemplified by my study with a focus on the existential dimensions of the nursing profession. The first part of the article introduces Marcel and his philosophical anthropology concerning our bodily existence as essential for shared lives with others. In the second part, this understanding of self and others is further developed by means of the hermeneutics of Gadamer and Ricoeur. In the third part, I present a way of applying hermeneutics in procedures for interviews, transcription, and analysis of data.
Existing chemicals: international activities.
Purchase, J F
1989-01-01
The standards of care used in the protection of the health and safety of people exposed to chemicals has increased dramatically in the last decade. Standards imposed by regulation and those adopted by industry have required a greater level of knowledge about the hazards of chemicals. In the E.E.C., the 6th amendment of the dangerous substances directive imposed the requirement that al new chemicals should be tested according to prescribed programme before introduction on to the market. The development of a European inventory of existing chemicals was an integral part of the 6th amendment. It has now become clear that increased standards of care referred to above must be applied to the chemicals on the inventory list. There is, however, a considerable amount of activity already under way in various international agencies. The OECD Chemicals Programme has been involved in considering the problem of existing chemicals for some time, and is producing a priority list and action programme. The International Programme on Chemical Safety produces international chemical safety cards, health and safety guides and environmental health criteria documents. The international register of potentially toxic compounds (part of UNEP) has prepared chemical data profiles on 990 compounds. The International Agency for Research on Cancer prepared monographs on the carcinogenic risk of chemicals to man. So far 42 volumes have been prepared covering about 900 substances. IARC and IPCS also prepare periodic reports on ongoing research on carcinogenicity or toxicity (respectively) of chemicals. The chemical industry through ECETOC (the European Chemical Industry Ecology and Toxicology Centre) has mounted a major initiative on existing chemicals. Comprehensive reviews of the toxicity of selected chemicals are published (Joint Assessment of Commodity Chemicals). In its technical report no. 30 ECETOC lists reviews and evaluations by major national and international organisations, which provides
Abbott, Timothy G; Charlton, David; Demaine, Erik D; Demaine, Martin L; Kominers, Scott D
2007-01-01
We prove that any finite collection of polygons of equal area has a common hinged dissection. That is, for any such collection of polygons there exists a chain of polygons hinged at vertices that can be folded in the plane continuously without self-intersection to form any polygon in the collection. This result settles the open problem about the existence of hinged dissections between pairs of polygons that goes back implicitly to 1864 and has been studied extensively in the past ten years. Our result generalizes and indeed builds upon the result from 1814 that polygons have common dissections (without hinges). We also extend our common dissection result to edge-hinged dissections of solid 3D polyhedra that have a common (unhinged) dissection, as determined by Dehn's 1900 solution to Hilbert's Third Problem. Our proofs are constructive, giving explicit algorithms in all cases. For a constant number of planar polygons, both the number of pieces and running time required by our construction are pseudopolynomial...
Unilateral contact problems variational methods and existence theorems
Eck, Christof; Krbec, Miroslav
2005-01-01
The mathematical analysis of contact problems, with or without friction, is an area where progress depends heavily on the integration of pure and applied mathematics. This book presents the state of the art in the mathematical analysis of unilateral contact problems with friction, along with a major part of the analysis of dynamic contact problems without friction. Much of this monograph emerged from the authors'' research activities over the past 10 years and deals with an approach proven fruitful in many situations. Starting from thin estimates of possible solutions, this approach is based on an approximation of the problem and the proof of a moderate partial regularity of the solution to the approximate problem. This in turn makes use of the shift (or translation) technique - an important yet often overlooked tool for contact problems and other nonlinear problems with limited regularity. The authors pay careful attention to quantification and precise results to get optimal bounds in sufficient conditions f...
HLA class II allele and haplotype frequencies in Ethiopian Amhara and Oromo populations.
Fort, M; de Stefano, G F; Cambon-Thomsen, A; Giraldo-Alvarez, P; Dugoujon, J M; Ohayon, E; Scano, G; Abbal, M
1998-04-01
HLA class II alleles were identified in 181 healthy unrelated Ethiopian children of both sexes and in 350 European controls from the South of France. The Ethiopian individuals belonged to the two major ethnic groups of the country: Oromo (N=83) and Amhara (N=98). In both panels, genetic polymorphism of HLA class II alleles was analysed for the first time by molecular typing of DRB1, DQA1 and DQB1 loci. Allelic and phenotypic frequencies were compared with those of European controls and other African populations. Construction of HLA class II three-locus haplotypes was also performed. The study revealed some differences between the two groups. Characteristic features of Central and North African populations appeared on the Ethiopian HLA genotypes. Surprisingly, DRB1*11 presented one of the lowest gene frequencies in both Ethiopian ethnic groups in contrast to Europeans and West Africans. Furthermore, this decrease was more marked than those observed using serological techniques in other geographically close East African countries. Oromo and Amhara only showed minor differences in spite of their different origins and histories. One significant difference consisted of a lower DRB1*01 gene frequency in Oromo as reported in most West African people. Some new or rare haplotypes were also observed in the Oromo group. Our results underline the distinctive features of the Ethiopian populations among the few HLA genotyping data available for East African groups and emphasise the major interest of such investigations in this region of Africa.
Genetic relationships among native americans based on beta-globin gene cluster haplotype frequencies
Rita de Cassia Mousinho-Ribeiro
2003-01-01
Full Text Available The distribution of b-globin gene haplotypes was studied in 209 Amerindians from eight tribes of the Brazilian Amazon: Asurini from Xingú, Awá-Guajá, Parakanã, Urubú-Kaapór, Zoé, Kayapó (Xikrin from the Bacajá village, Katuena, and Tiriyó. Nine different haplotypes were found, two of which (n. 11 and 13 had not been previously identified in Brazilian indigenous populations. Haplotype 2 (+ - - - - was the most common in all groups studied, with frequencies varying from 70% to 100%, followed by haplotype 6 (- + + - +, with frequencies between 7% and 18%. The frequency distribution of the b-globin gene haplotypes in the eighteen Brazilian Amerindian populations studied to date is characterized by a reduced number of haplotypes (average of 3.5 and low levels of heterozygosity and intrapopulational differentiation, with a single clearly predominant haplotype in most tribes (haplotype 2. The Parakanã, Urubú-Kaapór, Tiriyó and Xavante tribes constitute exceptions, presenting at least four haplotypes with relatively high frequencies. The closest genetic relationships were observed between the Brazilian and the Colombian Amerindians (Wayuu, Kamsa and Inga, and, to a lesser extent, with the Huichol of Mexico. North-American Amerindians are more differentiated and clearly separated from all other tribes, except the Xavante, from Brazil, and the Mapuche, from Argentina. A restricted pool of ancestral haplotypes may explain the low diversity observed among most present-day Brazilian and Colombian Amerindian groups, while interethnic admixture could be the most important factor to explain the high number of haplotypes and high levels of diversity observed in some South-American and most North-American tribes.
Haplotype frequencies at the DRD2 locus in populations of the East European Plain
Mikulich Alexey I
2009-09-01
Full Text Available Abstract Background It was demonstrated previously that the three-locus RFLP haplotype, TaqI B-TaqI D-TaqI A (B-D-A, at the DRD2 locus constitutes a powerful genetic marker and probably reflects the most ancient dispersal of anatomically modern humans. Results We investigated TaqI B, BclI, MboI, TaqI D, and TaqI A RFLPs in 17 contemporary populations of the East European Plain and Siberia. Most of these populations belong to the Indo-European or Uralic language families. We identified three common haplotypes, which occurred in more than 90% of chromosomes investigated. The frequencies of the haplotypes differed according to linguistic and geographical affiliation. Conclusion Populations in the northwestern (Byelorussians from Mjadel', northern (Russians from Mezen' and Oshevensk, and eastern (Russians from Puchezh parts of the East European Plain had relatively high frequencies of haplotype B2-D2-A2, which may reflect admixture with Uralic-speaking populations that inhabited all of these regions in the Early Middle Ages.
Allelic and haplotype frequencies of the p53 polymorphisms in brain tumor patients.
Biros, E; Kalina, I; Kohút, A; Bogyiová, E; Salagovic, J; Sulla, I
2002-01-01
The polymorphisms of the tumor suppressor gene p53 in exon 4 (p53 BstUI) and in intron 6 (p53 MspI) have been suggested to be associated with the genetically determined susceptibility in diverse types of human cancer. In our hospital-based case-control study, we examined the allele and genotype incidence of these polymorphisms as well as their haplotype combinations in 60 brain tumor patients (27 males and 33 females) and 183 controls without malignancies. The genotype characteristics were determined by the PCR-based RFLP method using DNA extracted from peripheral blood. In this study we show that the p53 BstUI and the p53 MspI polymorphisms are not associated with increased risk of brain tumors. Thus, we conclude that the p53 BstUI and the p53 MspI polymorphic sites within the tumor suppressor gene p53 do not represent genetic determinants of susceptibility to brain tumors.
Lebesgue Sets Immeasurable Existence
Diana Marginean Petrovai
2012-12-01
Full Text Available It is well known that the notion of measure and integral were released early enough in close connection with practical problems of measuring of geometric ﬁgures. Notion of measure was outlined in the early 20th century through H. Lebesgue’s research, founder of the modern theory of measure and integral. It was developed concurrently a technique of integration of functions. Gradually it was formed a speciﬁc area todaycalled the measure and integral theory. Essential contributions to building this theory was made by a large number of mathematicians: C. Carathodory, J. Radon, O. Nikodym, S. Bochner, J. Pettis, P. Halmos and many others. In the following we present several abstract sets, classes of sets. There exists the sets which are not Lebesgue measurable and the sets which are Lebesgue measurable but are not Borel measurable. Hence B ⊂ L ⊂ P(X.
Wagner, Serge
2016-01-01
Physics textbooks present Minkowski space as an almost pure mathematical construct, without any explicit restriction on a domain where it is applicable in physics. Meanwhile, its physical meaning cannot but follow the same premises as those which underlies the special relativity theory: motion of free point particles and propagation of electromagnetic waves. However, the common formalism of coordinate transformations between any two inertial frames appears too ponderous to infer the existence of Minkowski space. For this reason, the time dilation and retardation, the contraction of the length along and the spatial invariance across the direction of relative motion of two frames are presented in a coordinate-free manner. This results in the transformation between two frames in the form of relationships between the time moments and the components of the position vector of a given event, along and across the directions of the frames' motion. The obtained transformation rules for the components of the position ve...
Physiology of biological variation
Schouten, R.E.
2004-01-01
In agricultural products, variation exists in quality attributes between batches. Examples of this biological variation are well known and the general response is trying to suppress it as much as possible; to create uniformity using pre- andpostharvestmethods. This thesis
Hamilton, W. B.; Anderson, D. L.; Foulger, G. R.; Winterer, E. L.
conjectures are made ever more complex and implausible to encompass contrary data, and have no predictive value. The inescapable conclusion is that deep-mantle thermal plumes not only are unneces- sary but that they do not exist.
Existence results for anisotropic discrete boundary value problems
Avci Avci
2016-06-01
Full Text Available In this article, we prove the existence of nontrivial weak solutions for a class of discrete boundary value problems. The main tools used here are the variational principle and critical point theory.
Meta-Analysis of Mitochondrial DNA Variation in the Iberian Peninsula
Barral-Arca, Ruth; Pischedda, Sara; Gómez-Carballa, Alberto; Pastoriza, Ana; Mosquera-Miguel, Ana; López-Soto, Manuel; Martinón-Torres, Federico; Álvarez-Iglesias, Vanesa; Salas, Antonio
2016-01-01
The Iberian Peninsula has been the focus of attention of numerous studies dealing with mitochondrial DNA (mtDNA) variation, most of them targeting the control region segment. In the present study we sequenced the control region of 3,024 Spanish individuals from areas where available data were still limited. We also compiled mtDNA haplotypes from the literature involving 4,588 sequences and 28 population groups or small regions. We meta-analyzed all these data in order to shed further light on patterns of geographic variation, taking advantage of the large sample size and geographic coverage, in contrast with the atomized sampling strategy of previous work. The results indicate that the main mtDNA haplogroups show primarily clinal geographic patterns across the Iberian geography, roughly along a North-South axis. Haplogroup HV0 (where haplogroup U is nested) is more prevalent in the Franco Cantabrian region, in good agreement with previous findings that identified this area as a climate refuge during the Last Glacial Maximum (LGM), prior to a subsequent demographic re-expansion towards Central Europe and the Mediterranean. Typical sub-Saharan and North African lineages are slightly more prevalent in South Iberia, although at low frequencies; this pattern has been shaped mainly by the transatlantic slave trade and the Arab invasion of the Iberian Peninsula. The results also indicate that summary statistics that aim to measure molecular variation, or AMOVA, have limited sensitivity to detect population substructure, in contrast to patterns revealed by phylogeographic analysis. Overall, the results suggest that mtDNA variation in Iberia is substantially stratified. These patterns might be relevant in biomedical studies given that stratification is a common cause of false positives in case-control mtDNA association studies, and should be also considered when weighting the DNA evidence in forensic casework, which is strongly dependent on haplotype frequencies. PMID
Kierkegaardovo pojetí existence
Janatová, Kristýna
2016-01-01
The topic of the bachelor thesis is "Kierkegaard's conception of existence". There are both the life of the Danish philosopher Søren Kierkegaard and his philosophy discussed. The issue of human existence is analysed with its main three stages which are focused on aesthetics, ethics and religion. These stages of existence are at first described and afterwards compared with each other. The aesthetic represents the first stage of life and the religious stage is considered to be the highest aim o...
Variation of Fundamental Constants
Flambaum, V. V.
2006-11-01
Theories unifying gravity with other interactions suggest temporal and spatial variation of the fundamental ``constants'' in expanding Universe. The spatial variation can explain a fine tuning of the fundamental constants which allows humans (and any life) to appear. We appeared in the area of the Universe where the values of the fundamental constants are consistent with our existence. We present a review of recent works devoted to the variation of the fine structure constant α, strong interaction and fundamental masses. There are some hints for the variation in quasar absorption spectra. Big Bang nucleosynthesis, and Oklo natural nuclear reactor data. A very promising method to search for the variation of the fundamental constants consists in comparison of different atomic clocks. Huge enhancement of the variation effects happens in transition between accidentally degenerate atomic and molecular energy levels. A new idea is to build a ``nuclear'' clock based on the ultraviolet transition between very low excited state and ground state in Thorium nucleus. This may allow to improve sensitivity to the variation up to 10 orders of magnitude! Huge enhancement of the variation effects is also possible in cold atomic and molecular collisions near Feshbach resonance.
THE EXISTENCE OF CONNECTING ORBITS
无
2011-01-01
In this paper,using the notion of an isolating block and Conley's attractor theory,an existence criterion of trajectories connecting a pair of invariant sets of ordinary differential equations is given.
Goldsworthy, S; Francis, J; Boness, D; Fleischer, R
2000-01-01
The Juan Fernandez fur seal (Arctocephalus philippii was allegedly extremely abundant, numbering as many as 4 million prior to sealing which continued from the late 17th to the late 19th century. By the end of the sealing era the species was thought to be extinct until they were rediscovered at Alejandro Selkirk Island in 1965. Historic records would suggest that the species underwent a substantial population bottleneck as a result of commercial sealing, and from population genetic theory we predicted that the genetic variability in the species would be low. We compared the mtDNA control region sequence from 28 Juan Fernandez fur seals from two islands in the Juan Fernandez Archipelago (Chile). Contrary to expectation, we found that variation in the Juan Fernandez fur seals is not greatly reduced in comparison to other pinniped taxa, especially given the apparent severity of the bottleneck they underwent. We also determined minor, but significantly different haplotype frequencies among the populations on the two islands (Alejandro Selkirk and Robinson Crusoe Islands), but no difference in their levels of variability. Such differences may have arisen stochastically via a recent founder event from Alejandro Selkirk to Robinson Crusoe Island or subsequent genetic drift.
SYSTEM OF GENERALIZED VECTOR VARIATIONAL INEQUALITIES
Fang Yaping; Huang Nanjing
2005-01-01
In this paper, the authors introduce and study system of generalized vector variational inequalities. Under suitable conditions, the existence of solutions for system of generalized vector variational inequalities is presented by Kakutani-Fan-Glicksberg fixed point theorem.
Wladimir Antônio da Costa Garcia
2006-06-01
Full Text Available Temas como aquilo que há; o ser na sua singularidade (independentemente dos seus atributos ou das contingências; a relação entre escolha, necessidade e acaso; a relação entre possibilidade e impossibilidade (ou mesmo possíveis impossibilidades; e, por fim, neste ensaio, a relação entre caos e sistemas de ordem, sempre estiveram presentes, tanto na criação lírica como na reflexão filosófica. Logo, a existência não é privilégio do existencialismo. A noção de existência forma-se a partir daqueles temas: ela é secundária em relação aos pensamentos que a determinam. Trata-se, portanto, de uma “longa história, esta do sentido da existência” (DELEUZE, 1985. Desde o pensamento que se forma de uma culpa, desde o ressentimento e da vingança em torno da injustiça permanente do devir (quando a existência torna-se modificada pelos predicados, ou seja, niilista, à negação do todo e à absolvição da existência pela sua inocência (isto é, a afirmação do devir, o eterno retorno do ser do devir, etc., a noção de existência se desdobra. Sendo assim, o título deste trabalho, ao suspender aqueles sentidos estabelecidos, busca capturar a existência desde a potencialidade de suas relações com as configurações do poético.
Existing Steel Railway Bridges Evaluation
Vičan, Josef; Gocál, Jozef; Odrobiňák, Jaroslav; Koteš, Peter
2016-12-01
The article describes general principles and basis of evaluation of existing railway bridges based on the concept of load-carrying capacity determination. Compared to the design of a new bridge, the modified reliability level for existing bridges evaluation should be considered due to implementation of the additional data related to bridge condition and behaviour obtained from regular inspections. Based on those data respecting the bridge remaining lifetime, a modification of partial safety factors for actions and materials could be respected in the bridge evaluation process. A great attention is also paid to the specific problems of determination of load-caring capacity of steel railway bridges in service. Recommendation for global analysis and methodology for existing steel bridge superstructure load-carrying capacity determination are described too.
Williams, R C; McAuley, J E
1992-01-01
The genetic distribution of the HLA class I loci is presented for 619 "full blooded" Pima and Tohono O'odham Native Americans (Pimans) in the Gila River Indian Community. Variation in the Pimans is highly restricted. There are only three polymorphic alleles at the HLA-A locus, *A2, *A24, and *A31, and only 10 alleles with a frequency greater than 0.01 at HLA-B where *Bw48 (0.187), *B35 (0.173), and the new epitope *BN21 (0.143) have the highest frequencies. Two and three locus disequilibria values and haplotype frequencies are presented. Ten three-locus haplotypes account for more than 50% of the class I variation, with *A24 *BN21 *Cw3 (0.085) having the highest frequency. Gm allotypes demonstrate that little admixture from non-Indian populations has entered the Community since the 17th century when Europeans first came to this area. As a consequence many alleles commonly found in Europeans and European Americans are efficient markers for Caucasian admixture, while the "private" Indian alleles, *BN21 and *Bw48, can be used to measure Native American admixture in Caucasian populations. It is suggested that this distribution in "full blooded" Pimans approximates that of the Paleo-Indian migrants who first entered the Americas between 20,000 and 40,000 years ago.
Cooper, J D; Vitalis, R; Waser, P M; Gopurenko, D; Hellgren, E C; Gabor, T M; DeWoody, J A
2010-01-01
Recent advances in the statistical analysis of microsatellite data permit calculation of sex-specific dispersal rates through sex- and age-specific comparisons of genetic variation. This approach, developed for the analysis of data derived from co-dominant autosomal markers, should be applicable to a sex-specific marker such as mitochondrial DNA. To test this premise, we amplified a 449 bp control region DNA sequence from the mitochondrial genome of the collared peccary (Pecari tajacu), and estimated intra-class correlations among herds sampled from three Texas populations. Analyses on data partitioned by breeding group showed a clear signal of male-biased dispersal; sex-specific fixation indices associated with genetic variation among social groups within populations yielded values for females (F(GP)=0.91), which were significantly larger than values for males (F(GP)=0.24; P=0.0015). The same general pattern emerged when the analyses were conducted on age classes (albeit nonsignificantly), as well as categories of individuals that were predicted a posteriori to be dispersers (adult males) and philopatric (adult females and all immatures). By extending a previously published methodology based on biparentally inherited markers to matrilineally inherited haploid data, we calculated sex-specific rates of contemporary dispersal among social groups within populations (m(male symbol)=0.37). These results support the idea that mitochondrial DNA haplotype frequency data can be used to estimate sex-specific instantaneous dispersal rates in a social species.
[Does Stendhal's syndrome exist really?].
Valtueña Borque, Oscar
2009-01-01
The author, Medical Doctor and Master in Art History, dicusses the real existence of the so called by the Florentine MD Magherini Stendhal syndrome, first time published in 1980 to put out the sickness that some tourists in their Florentia visit suffered, because the big beauty they founded in the city, as the French writter Stendahl suffered two centuries ago.
Kobayashi, Sofie; Berge, Maria; Grout, Brian William Wilson
2017-01-01
This study contributes towards a better understanding of learning dynamics in doctoral supervision by analysing how learning opportunities are created in the interaction between supervisors and PhD students, using the notion of experiencing variation as a key to learning. Empirically, we have based...... were discussed, created more complex patterns of variation. Both PhD students and supervisors can learn from this. Understanding of this mechanism that creates learning opportunities can help supervisors develop their competences in supervisory pedagogy....
The EXIST Mission Concept Study
Fishman, Gerald J.; Grindlay, J.; Hong, J.
2008-01-01
EXIST is a mission designed to find and study black holes (BHs) over a wide range of environments and masses, including: 1) BHs accreting from binary companions or dense molecular clouds throughout our Galaxy and the Local Group, 2) supermassive black holes (SMBHs) lying dormant in galaxies that reveal their existence by disrupting passing stars, and 3) SMBHs that are hidden from our view at lower energies due to obscuration by the gas that they accrete. 4) the birth of stellar mass BHs which is accompanied by long cosmic gamma-ray bursts (GRBs) which are seen several times a day and may be associated with the earliest stars to form in the Universe. EXIST will provide an order of magnitude increase in sensitivity and angular resolution as well as greater spectral resolution and bandwidth compared with earlier hard X-ray survey telescopes. With an onboard optical-infra red (IR) telescope, EXIST will measure the spectra and redshifts of GRBs and their utility as cosmological probes of the highest z universe and epoch of reionization. The mission would retain its primary goal of being the Black Hole Finder Probe in the Beyond Einstein Program. However, the new design for EXIST proposed to be studied here represents a significant advance from its previous incarnation as presented to BEPAC. The mission is now less than half the total mass, would be launched on the smallest EELV available (Atlas V-401) for a Medium Class mission, and most importantly includes a two-telescope complement that is ideally suited for the study of both obscured and very distant BHs. EXIST retains its very wide field hard X-ray imaging High Energy Telescope (HET) as the primary instrument, now with improved angular and spectral resolution, and in a more compact payload that allows occasional rapid slews for immediate optical/IR imaging and spectra of GRBs and AGN as well as enhanced hard X-ray spectra and timing with pointed observations. The mission would conduct a 2 year full sky survey in
Cluster pre-existence probability
Rajeswari, N.S.; Vijayaraghavan, K.R.; Balasubramaniam, M. [Bharathiar University, Department of Physics, Coimbatore (India)
2011-10-15
Pre-existence probability of the fragments for the complete binary spectrum of different systems such as {sup 56}Ni, {sup 116}Ba, {sup 226}Ra and {sup 256}Fm are calculated, from the overlapping part of the interaction potential using the WKB approximation. The role of reduced mass as well as the classical hydrodynamical mass in the WKB method is analysed. Within WKB, even for negative Q -value systems, the pre-existence probability is calculated. The calculations reveal rich structural information. The calculated results are compared with the values of preformed cluster model of Gupta and collaborators. The mass asymmetry motion is shown here for the first time as a part of relative separation motion. (orig.)
Existence of undiscovered Uranian satellites
Boice, D.C.
1986-04-01
Structure in the Uranian ring system as observed in recent occultations may contain indirect evidence for the existence of undiscovered satellites. Using the Alfven and Arrhenius (1975, 1976) scenario for the formation of planetary systems, the orbital radii of up to nine hypothetical satellites interior to Miranda are computed. These calculations should provide interesting comparisons when the results from the Voyager 2 encounter with Uranus are made public. 15 refs., 1 fig., 1 tab.
Periodic insolation variations on Mars.
Murray, B C; Ward, W R; Yeung, S C
1973-05-11
Previously unrecognized insolation variations on Mars are a consequence of periodic variations in eccentricity, first established by the theory of Brouwer and Van Woerkom (1950). Such annual insolation variations, characterized by both 95,000-year and 2,000,000-year periodicities, may actually be recorded in newly discovered layered deposits in the polar regions of Mars. An additional north-south variation in seasonal insolation, but not average annual insolation, exists with 51,000-year and 2,000,000-year periodicities.
Saddle scars Existence and applications
Mendes, R V
1998-01-01
A quantum scar is a wave function which displays an high intensity in the region of a classical unstable periodic orbit. Saddle scars are states related to the unstable harmonic motions along the stable manifold of a saddle point of the potential. Using a semiclassical method it is shown that, independently of the overall structure of the potential, the local dynamics of the saddle point is sufficient to insure the general existence of this type of scars and their factorized structure is obtained. Potentially useful situations are identified, where these states appear (directly or in disguise) and might be used for quantum control purposes.
Moiseiwitsch, B L
2004-01-01
This graduate-level text's primary objective is to demonstrate the expression of the equations of the various branches of mathematical physics in the succinct and elegant form of variational principles (and thereby illuminate their interrelationship). Its related intentions are to show how variational principles may be employed to determine the discrete eigenvalues for stationary state problems and to illustrate how to find the values of quantities (such as the phase shifts) that arise in the theory of scattering. Chapter-by-chapter treatment consists of analytical dynamics; optics, wave mecha
Existence and non-existence of solutions for a p(x-biharmonic problem
Ghasem A. Afrouzi
2015-06-01
Full Text Available In this article, we study the following problem with Navier boundary conditions $$\\displaylines{ \\Delta (|\\Delta u|^{p(x-2}\\Delta u+|u|^{p(x-2}u =\\lambda |u|^{q(x-2}u +\\mu|u|^{\\gamma(x-2}u\\quad \\text{in } \\Omega,\\cr u=\\Delta u=0 \\quad \\text{on } \\partial\\Omega. }$$ where $\\Omega$ is a bounded domain in $\\mathbb{R}^{N}$ with smooth boundary $\\partial \\Omega$, $N\\geq1$. $p(x,q(x$ and $\\gamma(x$ are continuous functions on $\\overline{\\Omega}$, $\\lambda$ and $\\mu$ are parameters. Using variational methods, we establish some existence and non-existence results of solutions for this problem.
Turbulence: does energy cascade exist?
Josserand, Christophe; Lehner, Thierry; Pomeau, Yves
2016-01-01
To answer the question whether a cascade of energy exists or not in turbulence, we propose a set of correlation functions able to test if there is an irreversible transfert of energy, step by step, from large to small structures. These tests are applied to real Eulerian data of a turbulent velocity flow, taken in the wind grid tunnel of Modane, and also to a prototype model equation for wave turbulence. First we demonstrate the irreversible character of the flow by using multi-time correlation function at a given point of space. Moreover the unexpected behavior of the test function leads us to connect irreversibility and finite time singularities (intermittency). Secondly we show that turbulent cascade exists, and is a dynamical process, by using a test function depending on time and frequency. The cascade shows up only in the inertial domain where the kinetic energy is transferred more rapidly (on average) from the wavenumber $k_{1}$ to $k_{2}$ than from $k_{1}$ to $k'_{2}$ larger than $k_{2}$.
Uniqueness and existence for bounded boundary value problems
Ehme, J.; Lanz, A.
2006-01-01
The existence and uniqueness of solutions for the boundary value problems with general linear point evaluation boundary conditions is established. We assume that f is bounded and that there is uniqueness on a homogeneous problem and on the linear variational problems. (c) 2005 Elsevier Inc. All righ
Straightening: existence, uniqueness and stability.
Destrade, M; Ogden, R W; Sgura, I; Vergori, L
2014-04-08
One of the least studied universal deformations of incompressible nonlinear elasticity, namely the straightening of a sector of a circular cylinder into a rectangular block, is revisited here and, in particular, issues of existence and stability are addressed. Particular attention is paid to the system of forces required to sustain the large static deformation, including by the application of end couples. The influence of geometric parameters and constitutive models on the appearance of wrinkles on the compressed face of the block is also studied. Different numerical methods for solving the incremental stability problem are compared and it is found that the impedance matrix method, based on the resolution of a matrix Riccati differential equation, is the more precise.
Straightening: existence, uniqueness and stability
Destrade, M.; Ogden, R. W.; Sgura, I.; Vergori, L.
2014-01-01
One of the least studied universal deformations of incompressible nonlinear elasticity, namely the straightening of a sector of a circular cylinder into a rectangular block, is revisited here and, in particular, issues of existence and stability are addressed. Particular attention is paid to the system of forces required to sustain the large static deformation, including by the application of end couples. The influence of geometric parameters and constitutive models on the appearance of wrinkles on the compressed face of the block is also studied. Different numerical methods for solving the incremental stability problem are compared and it is found that the impedance matrix method, based on the resolution of a matrix Riccati differential equation, is the more precise. PMID:24711723
Local Existence of Spinor Potentials
Andersson, F
1999-01-01
We present a new, simple proof of existence for the Lanczos spinor potential in 3+1 dimensions that introduces a potential $T_{ABCD}= T_{(ABC)D}$ of the Lanczos potential together with several generalizations to other index configurations and metric signatures. The potential $T_{ABCD}$ can also be used to express, in a concise way, the gauge freedom left in the Lanczos potential after the differential gauge has been specified. We consider Einstein spacetimes and prove that in those spacetimes any symmetric (3,1)-spinor possesses a symmetric potential $H_{ABA'B'}$. Potentials of this type have earlier occurred in some special cases investigated e.g., by Torres del Castillo, Bergqvist and ourselves.
Does the polystomatic gland exist?
Imai, M; Shibata, T; Moriguchi, K; Kinbara, M
1989-03-01
According to the P.N.A., the N.A.J. and some scholars, the sublingual gland has the ductus sublingualis major and ductus sublinguales minores. This means that the gland is a polystomatic gland. We intended to determine whether the so-called polystomatic gland exists or not. 1. According to the P.N.A., the N.A.J. and some scholars, the gl. sublingualis has the ductus sublingualis major and ductus sublinguales minores. This means the gland is a polystomatic gland. However, the formation of one gland with plural excretory ducts is embryologically impossible, in other words, the polystomatic gland does not exist. 2. Many scholars described that the gl. sublingualis was composed of the gl. sublingualis major and g11. sublinguales minores. However, they are completely different kinds of glands. Accordingly, we suggest the terms for these glands: the g1. sublingualis and its ductus sublingualis ("major" is useless), the g11. sublinguales minores and their ductus sublinguales minores. 3. The N.A.V.J. and some scholars use the term g1. sublingualis polystomatica or parvicanalaris. However, this is a group of a number of independent glands each of which has its own excretory duct. Such a gland should not be regarded as a single gland. We suggest that the term g11. sublinguales minores and their excretory ducts should be replaced with the term the ductus sublinguales minores. 4. The g1. lingualis anterior, g1. retromolaris and g1. lacrimalis are not single glands but a group of several independent glands each of which has its own excretory duct. Accordingly, they should be termed the g11. linguales anteriores, g11. retromolares and g11. lacrimales such as the g11. labiales, g11. buccales and g11. palatinae.
Nagoshi, R. N.; Silvie, Pierre; Meagher, R.L.
2007-01-01
Fall armyworm, Spodoptera frugiperda (J.E. Smith) (Lepidoptera: Noctuidae), is a major economic pest throughout the Western Hemisphere. Populations can be subdivided into two morphologically identical but genetically distinct strains (corn-strain and rice-strain) that differ in their host plant preferences. These strains can be distinguished by using polymorphisms in the mitochondrial cytochrome oxidase I gene. Additional sequence analysis of this locus identified two sites that were highly p...
Nagoshi, Rod N; Silvie, Pierre; Meagher, Robert L
2007-06-01
Fall armyworm, Spodoptera frugiperda (J.E. Smith) (Lepidoptera: Noctuidae), is a major economic pest throughout the Western Hemisphere. Populations can be subdivided into two morphologically identical but genetically distinct strains (corn-strain and rice-strain) that differ in their host plant preferences. These strains can be distinguished by using polymorphisms in the mitochondrial cytochrome oxidase 1 gene. Additional sequence analysis of this locus identified two sites that were highly polymorphic in the corn-strain population and that produced four different haplotype subgroups. Comparisons of the frequency distribution of these haplotypes found no seasonal or plant host specificities, but they did demonstrate that the Brazil corn-strain population is different from corn-strain fall armyworm found in Florida. The development of a rapid means of distinguishing fall armyworm populations originating from Brazil versus Florida provides an opportunity for investigating and comparing the genetic complexity and long-range movements of this important agricultural pest.
Diversity Outbred Mice at 21: Maintaining Allelic Variation in the Face of Selection
Elissa J. Chesler
2016-12-01
Full Text Available Multi-parent populations (MPPs capture and maintain the genetic diversity from multiple inbred founder strains to provide a resource for high-resolution genetic mapping through the accumulation of recombination events over many generations. Breeding designs that maintain a large effective population size with randomized assignment of breeders at each generation can minimize the impact of selection, inbreeding, and genetic drift on allele frequencies. Small deviations from expected allele frequencies will have little effect on the power and precision of genetic analysis, but a major distortion could result in reduced power and loss of important functional alleles. We detected strong transmission ratio distortion in the Diversity Outbred (DO mouse population on chromosome 2, caused by meiotic drive favoring transmission of the WSB/EiJ allele at the R2d2 locus. The distorted region harbors thousands of polymorphisms derived from the seven non-WSB founder strains and many of these would be lost if the sweep was allowed to continue. To ensure the utility of the DO population to study genetic variation on chromosome 2, we performed an artificial selection against WSB/EiJ alleles at the R2d2 locus. Here, we report that we have purged the WSB/EiJ allele from the drive locus while preserving WSB/EiJ alleles in the flanking regions. We observed minimal disruption to allele frequencies across the rest of the autosomal genome. However, there was a shift in haplotype frequencies of the mitochondrial genome and an increase in the rate of an unusual sex chromosome aneuploidy. The DO population has been restored to genome-wide utility for genetic analysis, but our experience underscores that vigilant monitoring of similar genetic resource populations is needed to ensure their long-term utility.
Williams, R C; McAuley, J E
1992-01-01
A genetic distribution for the HLA class II loci is described for 349 "full-blooded" Pima and Tohono O'odham Indians (Pimans) in the Gila River Indian Community. A high frequency epitope in the *DRw52 family was defined by reactions with 31 alloantisera, which we have designated *DR3X6. It segregates as a codominant allele at HLA-DR with alleles *DR2, *DR4, and *DRw8, and has the highest frequency yet reported for an HLA-DR specificity, 0.735. It forms a common haplotype with *DRw52 and *DQw3 that is a valuable marker for genetic admixture and anthropological studies. Phenotype and allele frequencies, and haplotype frequencies for two and three loci, are presented. Variation at these loci is highly restricted, the mean heterozygosity for HLA-DR and HLA-DQ being 0.361. The Pimans represent a contemporary model for the Paleo-Indians who first entered North America 20,000 to 40,000 years ago.
Existe sujeito em Michel Maffesoli?
Marli Appel da Silva
2010-06-01
Full Text Available Este ensaio discute a concepção de sujeito na abordagem teórica de Michel Maffesoli. As ideias desse autor estão em voga em alguns meios acadêmicos no Brasil e são difundidas por algumas mídias de grande circulação nacional. Entretanto, ao longo de suas obras, os pressupostos que definem quem é o sujeito maffesoliano se encontram pouco clarificados. Portanto, para alcançar o objetivo a que se propõe, este ensaio desenvolve uma análise da epistemologia e da ontologia maffesoliana com a finalidade de compreender as origens dos pressupostos desse autor, ou seja, as teorias e os autores em que Maffesoli se baseou para desenvolver uma visão de sujeito. Com essa compreensão, pretende-se responder à questão: existe sujeito na abordagem teórica de Maffesoli.
Does Metabolically Healthy Obesity Exist?
Muñoz-Garach, Araceli; Cornejo-Pareja, Isabel; Tinahones, Francisco J.
2016-01-01
The relationship between obesity and other metabolic diseases have been deeply studied. However, there are clinical inconsistencies, exceptions to the paradigm of “more fat means more metabolic disease”, and the subjects in this condition are referred to as metabolically healthy obese (MHO).They have long-standing obesity and morbid obesity but can be considered healthy despite their high degree of obesity. We describe the variable definitions of MHO, the underlying mechanisms that can explain the existence of this phenotype caused by greater adipose tissue inflammation or the different capacity for adipose tissue expansion and functionality apart from other unknown mechanisms. We analyze whether these subjects improve after an intervention (traditional lifestyle recommendations or bariatric surgery) or if they stay healthy as the years pass. MHO is common among the obese population and constitutes a unique subset of characteristics that reduce metabolic and cardiovascular risk factors despite the presence of excessive fat mass. The protective factors that grant a healthier profile to individuals with MHO are being elucidated. PMID:27258304
FROG - Fingerprinting Genomic Variation Ontology.
E Abinaya
Full Text Available Genetic variations play a crucial role in differential phenotypic outcomes. Given the complexity in establishing this correlation and the enormous data available today, it is imperative to design machine-readable, efficient methods to store, label, search and analyze this data. A semantic approach, FROG: "FingeRprinting Ontology of Genomic variations" is implemented to label variation data, based on its location, function and interactions. FROG has six levels to describe the variation annotation, namely, chromosome, DNA, RNA, protein, variations and interactions. Each level is a conceptual aggregation of logically connected attributes each of which comprises of various properties for the variant. For example, in chromosome level, one of the attributes is location of variation and which has two properties, allosomes or autosomes. Another attribute is variation kind which has four properties, namely, indel, deletion, insertion, substitution. Likewise, there are 48 attributes and 278 properties to capture the variation annotation across six levels. Each property is then assigned a bit score which in turn leads to generation of a binary fingerprint based on the combination of these properties (mostly taken from existing variation ontologies. FROG is a novel and unique method designed for the purpose of labeling the entire variation data generated till date for efficient storage, search and analysis. A web-based platform is designed as a test case for users to navigate sample datasets and generate fingerprints. The platform is available at http://ab-openlab.csir.res.in/frog.
Langford, Dale J; Paul, Steven M; West, Claudia M; Dunn, Laura B; Levine, Jon D; Kober, Kord M; Dodd, Marylin J; Miaskowski, Christine; Aouizerat, Bradley E
2015-03-01
Persistent pain after breast cancer surgery is a common clinical problem. Given the role of potassium channels in modulating neuronal excitability, coupled with recently published genetic associations with preoperative breast pain, we hypothesized that variations in potassium channel genes will be associated with persistent postsurgical breast pain. In this study, associations between 10 potassium channel genes and persistent breast pain were evaluated. Using growth mixture modeling (GMM), 4 distinct latent classes of patients, who were assessed before and monthly for 6 months after breast cancer surgery, were identified previously (ie, No Pain, Mild Pain, Moderate Pain, Severe Pain). Genotyping was done using a custom array. Using logistic regression analyses, significant differences in a number of genotype or haplotype frequencies were found between: Mild Pain vs No Pain and Severe Pain vs No Pain classes. Seven single-nucleotide polymorphisms (SNPs) across 5 genes (ie, potassium voltage-gated channel, subfamily A, member 1 [KCNA1], potassium voltage-gated channel, subfamily D, member 2 [KCND2], potassium inwardly rectifying channel, subfamily J, members 3 and 6 (KCNJ3 and KCNJ6), potassium channel, subfamily K, member 9 [KCNK9]) were associated with membership in the Mild Pain class. In addition, 3 SNPs and 1 haplotype across 4 genes (ie, KCND2, KCNJ3, KCNJ6, KCNK9) were associated with membership in the Severe Pain class. These findings suggest that variations in potassium channel genes are associated with both mild and severe persistent breast pain after breast cancer surgery. Although findings from this study warrant replication, they provide intriguing preliminary information on potential therapeutic targets.
Economic evaluations of personalized medicine: existing challenges and current developments
Shabaruddin FH
2015-06-01
Full Text Available Fatiha H Shabaruddin,1 Nigel D Fleeman,2 Katherine Payne3 1Department of Pharmacy, University of Malaya, Kuala Lumpur, Malaysia; 2Liverpool Reviews and Implementation Group (LRiG, University of Liverpool, Liverpool, UK; 3Institute of Population Health, The University of Manchester, Manchester, UK Abstract: Personalized medicine, with the aim of safely, effectively, and cost-effectively targeting treatment to a prespecified patient population, has always been a long-time goal within health care. It is often argued that personalizing treatment will inevitably improve clinical outcomes for patients and help achieve more effective use of health care resources. Demand is increasing for demonstrable evidence of clinical and cost-effectiveness to support the use of personalized medicine in health care. This paper begins with an overview of the existing challenges in conducting economic evaluations of genetics- and genomics-targeted technologies, as an example of personalized medicine. Our paper illustrates the complexity of the challenges faced by these technologies by highlighting the variations in the issues faced by diagnostic tests for somatic variations, generally referring to genetic variation in a tumor, and germline variations, generally referring to inherited genetic variation in enzymes involved in drug metabolic pathways. These tests are typically aimed at stratifying patient populations into subgroups on the basis of clinical effectiveness (response or safety (avoidance of adverse events. The paper summarizes the data requirements for economic evaluations of genetics and genomics-based technologies while outlining that the main challenges relating to data requirements revolve around the availability and quality of existing data. We conclude by discussing current developments aimed to address the challenges of assessing the cost-effectiveness of genetics and genomics-based technologies, which revolve around two central issues that are
Global existence for a singular Gierer-Meinhardt system
Chen, Shaohua; Salmaniw, Yurij; Xu, Runzhang
2017-02-01
This paper is concerned with existence results for a singular Gierer-Meinhardt system subject to zero Dirichlet boundary conditions, which originally arose in studies of pattern-formation in biology. The mathematical difficulties are that the system becomes singular near the boundary and it lacks a variational structure. We use a functional method to obtain both upper and lower bounds for the perturbed system and then use Sobolev embedding theorem to prove the existence of a pair of positive solutions under suitable conditions. This method is first used in a singular parabolic system and is completely different than the traditional methods of sub and super solutions.
The Basic Existence Theorem of Riemann-Stieltjes Integral
Nakasho Kazuhisa
2016-12-01
Full Text Available In this article, the basic existence theorem of Riemann-Stieltjes integral is formalized. This theorem states that if f is a continuous function and ρ is a function of bounded variation in a closed interval of real line, f is Riemann-Stieltjes integrable with respect to ρ. In the first section, basic properties of real finite sequences are formalized as preliminaries. In the second section, we formalized the existence theorem of the Riemann-Stieltjes integral. These formalizations are based on [15], [12], [10], and [11].
10 CFR 4.127 - Existing facilities.
2010-01-01
... 10 Energy 1 2010-01-01 2010-01-01 false Existing facilities. 4.127 Section 4.127 Energy NUCLEAR... 1973, as Amended Discriminatory Practices § 4.127 Existing facilities. (a) Accessibility. A recipient... make each of its existing facilities or every part of an existing facility accessible to and usable by...
28 CFR 41.57 - Existing facilities.
2010-07-01
... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Existing facilities. 41.57 Section 41.57... Practices Program Accessibility § 41.57 Existing facilities. (a) A recipient shall operate each program or... existing facilities or every part of an existing facility accessible to and usable by handicapped...
Variational and quasi-variational inequalities in mechanics
Kravchuk, Alexander S
2007-01-01
The essential aim of the present book is to consider a wide set of problems arising in the mathematical modelling of mechanical systems under unilateral constraints. In these investigations elastic and non-elastic deformations, friction and adhesion phenomena are taken into account. All the necessary mathematical tools are given: local boundary value problem formulations, construction of variational equations and inequalities, and the transition to minimization problems, existence and uniqueness theorems, and variational transformations (Friedrichs and Young-Fenchel-Moreau) to dual and saddle-point search problems. Important new results concern contact problems with friction. The Coulomb friction law and some others are considered, in which relative sliding velocities appear. The corresponding quasi-variational inequality is constructed, as well as the appropriate iterative method for its solution. Outlines of the variational approach to non-stationary and dissipative systems and to the construction of the go...
Urban building recognition during significant temporal variations
Nguyen, Phuong Giang; Andersen, Hans Jørgen
2008-01-01
In literature, existing researches on building recognition mainly concentrate on scales, rotations, and viewpoints variance. In urban environment, large temporal variations of weather and lighting conditions should also be considered as major challenges for robust recognition. For instances...
Synchronous Lagrangian variational principles in General Relativity
Cremaschini, Claudio
2016-01-01
The problem of formulating synchronous variational principles in the context of General Relativity is discussed. Based on the analogy with classical relativistic particle dynamics, the existence of variational principles is pointed out in relativistic classical field theory which are either asynchronous or synchronous. The historical Einstein-Hilbert and Palatini variational formulations are found to belong to the first category. Nevertheless, it is shown that an alternative route exists which permits one to cast these principles in terms of equivalent synchronous Lagrangian variational formulations. The advantage is twofold. First, synchronous approaches allow one to overcome the lack of gauge symmetry of the asynchronous principles. Second, the property of manifest covariance of the theory is also restored at all levels, including the symbolic Euler-Lagrange equations, with the variational Lagrangian density being now identified with a $4-$scalar. As an application, a joint synchronous variational principle...
A Note on Existence and Stability of Solutions for Semilinear Dirichlet Problems
Marek Galewski
2011-05-01
We provide existence and stability results for a fourth-order semilinear Dirichlet problem in the case when both the coefficients of the differential operator and the nonlinear term depend on the numerical parameter. We use a dual variational method.
10 CFR 611.206 - Existing facilities.
2010-01-01
... 10 Energy 4 2010-01-01 2010-01-01 false Existing facilities. 611.206 Section 611.206 Energy... PROGRAM Facility/Funding Awards § 611.206 Existing facilities. The Secretary shall, in making awards to those manufacturers that have existing facilities, give priority to those facilities that are oldest or...
45 CFR 1170.32 - Existing facilities.
2010-10-01
... 45 Public Welfare 3 2010-10-01 2010-10-01 false Existing facilities. 1170.32 Section 1170.32... ASSISTED PROGRAMS OR ACTIVITIES Accessibility § 1170.32 Existing facilities. (a) Accessibility. A recipient... require a recipient to make each of its existing facilities or every part of a facility accessible to and...
45 CFR 1151.22 - Existing facilities.
2010-10-01
... 45 Public Welfare 3 2010-10-01 2010-10-01 false Existing facilities. 1151.22 Section 1151.22... Prohibited Accessibility § 1151.22 Existing facilities. (a) A recipient shall operate each program or... make each of its existing facilities or every part of a facility accessible to and usable by...
14 CFR 1251.301 - Existing facilities.
2010-01-01
... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Existing facilities. 1251.301 Section 1251... HANDICAP Accessibility § 1251.301 Existing facilities. (a) Accessibility. A recipient shall operate each... existing facilities or every part of a facility accessible to and usable by handicapped persons. (b...
45 CFR 605.22 - Existing facilities.
2010-10-01
... 45 Public Welfare 3 2010-10-01 2010-10-01 false Existing facilities. 605.22 Section 605.22 Public... Accessibility § 605.22 Existing facilities. (a) Accessibility. A recipient shall operate each program or... existing facilities or every part of a facility accessible to and usable by qualified handicapped persons...
34 CFR 104.22 - Existing facilities.
2010-07-01
... 34 Education 1 2010-07-01 2010-07-01 false Existing facilities. 104.22 Section 104.22 Education... Accessibility § 104.22 Existing facilities. (a) Accessibility. A recipient shall operate its program or activity.... This paragraph does not require a recipient to make each of its existing facilities or every part of a...
28 CFR 42.521 - Existing facilities.
2010-07-01
... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Existing facilities. 42.521 Section 42...-Implementation of Section 504 of the Rehabilitation Act of 1973 Accessibility § 42.521 Existing facilities. (a... section does not require a recipient to make each of its existing facilities or every part of a...
45 CFR 1232.14 - Existing facilities.
2010-10-01
... 45 Public Welfare 4 2010-10-01 2010-10-01 false Existing facilities. 1232.14 Section 1232.14... ASSISTANCE Accessibility § 1232.14 Existing facilities. (a) A recipient shall operate each program or... existing facilities or every part of a facility accessible to and usable by handicapped persons. (b)...
28 CFR 35.150 - Existing facilities.
2010-07-01
... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Existing facilities. 35.150 Section 35... STATE AND LOCAL GOVERNMENT SERVICES Program Accessibility § 35.150 Existing facilities. (a) General. A... paragraph does not— (1) Necessarily require a public entity to make each of its existing...
Research on Inequalities Exists in the Workplace
布乃鹏; 樊晶晶; 刘淑华
2013-01-01
The is ue of inequalities exists in the workplace has been widely debated in our community recently. And then this essay wil argue inequalities exist in the workplace, in terms of ethnic, gender, and disability. This es ay would of er four perspectives about the view inequalities exist in the workplace and discuss the response from the state, employers and unions.
Existence conditions for unknown input functional observers
Fernando, T.; MacDougall, S.; Sreeram, V.; Trinh, H.
2013-01-01
This article presents necessary and sufficient conditions for the existence and design of an unknown input Functional observer. The existence of the observer can be verified by computing a nullspace of a known matrix and testing some matrix rank conditions. The existence of the observer does not require the satisfaction of the observer matching condition (i.e. Equation (16) in Hou and Muller 1992, 'Design of Observers for Linear Systems with Unknown Inputs', IEEE Transactions on Automatic Control, 37, 871-875), is not limited to estimating scalar functionals and allows for arbitrary pole placement. The proposed observer always exists when a state observer exists for the unknown input system, and furthermore, the proposed observer can exist even in some instances when an unknown input state observer does not exist.
Gu, Xia; Shen, Yan; Fu, Ling; Zuo, Hong-Yun; Yasen, Halida; He, Ping; Guo, Xin-Hong; Shi, Yu-wei; Yusufu, Muhabaiti
2014-01-01
Polymorphisms of inflammation-related genes have been found to be associated with non-Hodgkin lymphoma (NHL) or some of its subtypes, but only a few relevant data have been reported in China. In this study, the Snapshot method was used to assess genetic variation; a total of 14 single nucleotide polymorphisms (SNPs) for 6 inflammatory factors in 157 NHL cases (64 Uygur ethnic subjects, 93 Han Chinese) and 435 controls (231 Uygur and 204 Han Chinese) were studied from the Xinjiang province of China. Haplotype distribution was estimated using PHASE 2.3 software. Statistical differences in the genotype and haplotype frequencies between case and control groups were also considered and estimated. For the Han population, the geneotype distributions for TNF- αrs1800629, TNF-αrs1800630, IL-6 rs1800795, IL-6 rs1800797, NF-KB1 rs1585215 and TLR-4 rs4986790 showed significant differences between the case and control groups (p<0.05). The TNF-α gene frequencies of ACG and CCA haplotypes in the cases were higher than in the controls (OR=2.45, 95% CI: 1.55-3.89, p=0.0002, OR=2.53, 95% CI: 1.10-5.80, p=0.029, respectively), and the same findings were detected for TNF-β gene CA haplotype (OR=1.87, 95% CI: 1.21-2.90, p=0.0054). However, for the Uygur population, no such significant differences were detected within the gene-type distribution of the 14 SNPs. The TNF-α gene frequency of the CCA haplotype between the two groups (OR=1.98, 95% CI: 1.11-3.51, p=0.021) revealed a statistically significant difference. Our results showed that polymorphic variations of inflammation-related genes could be important to the NHL etiology of the Han population, and that these may only have limited influence on the Uygur population.
Homotopy Method for Variational Inequalities
无
2001-01-01
@@Solving a finite-dimensional variational inequality is to find a vector x* ∈ X Rn such that where X is a nonempty, closed and convex subset of Rn and F is a mapping from Rn to itself,denoted by VI(X, F). The variational inequality problem (VIP) has had many successful practical applications in the last three decades. It has been used to formulate and investigate equilibrium models arising in economics, transportation, regional science and operations research. So far, a large number of existence conditions have been developed in the literature. Harker and Pang[1] gave excellent surveys of theories, methods and applications of VIPs.
Asymptotic Existence of Nearly Kirkman Systems
沈灏; 储文松
1994-01-01
It is proved in this paper that,for any given positive integer k≥2,there exists a constant v0=v0(k) such that for v≥v0,the necessary condition v=0 (mod k(k-)) for the existence of a nearly Kirkman system NKS (2,k,v) is also sufficient.Thus we have completely determined the asymptotic existence of NKS.
Quantum theory is classical mechanics with non-local existence
Hegseth, John
2009-01-01
I propose a new and direct connection between classical mechanics and quantum mechanics where I derive the quantum mechanical propagator from a variational principle. This variational principle is Hamilton's modified principle generalized to allow many paths due to the non-local existence of particles in phase space. This principle allows a physical system to evolve non-locally in phase space while still allowing a representation that uses many classical paths. Whereas a point in phase space represents a classical system's state, I represent the state of a non-local system by a mixed trajectory. This formulation naturally leads to the transactional interpretation for resolving the paradoxes of the measurement problem. This principle also suggests a more flexible framework for formulating theories based on invariant actions and provides a single conceptual framework for discussing many areas of science.
Do Phantom Cuntz-Krieger Algebras Exist?
Arklint, Sara E.
2013-01-01
If phantom Cuntz-Krieger algebras do not exist, then purely infinite Cuntz-Krieger algebras can be characterized by outer properties. In this survey paper, a summary of the known results on non-existence of phantom Cuntz-Krieger algebras is given......If phantom Cuntz-Krieger algebras do not exist, then purely infinite Cuntz-Krieger algebras can be characterized by outer properties. In this survey paper, a summary of the known results on non-existence of phantom Cuntz-Krieger algebras is given...
God exists with probability 1/(H+1)
Hoey, Jesse
2012-01-01
This note will address the issue of the existence of God from a game theoretic perspective. We will show that, under certain assumptions, man cannot simultaneously be (i) rational and (ii) believe that an infinitely powerful God exists. Game theory and decision theory have long been used to address this thorny question.
Existence Regions of Shock Wave Triple Configurations
Bulat, Pavel V.; Chernyshev, Mikhail V.
2016-01-01
The aim of the research is to create the classification for shock wave triple configurations and their existence regions of various types: type 1, type 2, type 3. Analytical solutions for limit Mach numbers and passing shock intensity that define existence region of every type of triple configuration have been acquired. The ratios that conjugate…
On the existence of consistent price systems
Bayraktar, Erhan; Pakkanen, Mikko S.; Sayit, Hasanjan
2014-01-01
We formulate a sufficient condition for the existence of a consistent price system (CPS), which is weaker than the conditional full support condition (CFS). We use the new condition to show the existence of CPSs for certain processes that fail to have the CFS property. In particular this condition...
Chong Qing CHENG
2011-01-01
Given an integrable Hamiltonian ho with n-degrees of freedom and a Diophantine frequency w, then, arbitrarily close to ho in the Cr topology with r ＜ 2n, there exists an analytical Hamiltonian h∈ with no KAM torus of rotation vector w. In contrast with it, KAM tori exist if perturbations are small in Cr topology with r ＞ 2n.
Structural reliability of existing city bridges
Hellebrandt, L.; Steenbergen, R.; Vrouwenvelder, T.; Blom, K.
2015-01-01
Full probabilistic reliability analysis may be valuable for assessing existing structures. Measures for increasing the safety level are quite costly for existing structures and may be unnecessary when such a decision is grounded on a conservative analysis for determining the structural reliability.
10 CFR 1040.72 - Existing facilities.
2010-01-01
... 10 Energy 4 2010-01-01 2010-01-01 false Existing facilities. 1040.72 Section 1040.72 Energy... § 1040.72 Existing facilities. (a) Accessibility. A recipient shall operate any program or activity to... facilities or every part of a facility accessible to and useable by handicapped persons. (b) Methods. A...
On determining if a specular point exists
Rusch, W; Sørensen, O
1979-01-01
A technique is presented whereby the existence of a specular point on a convex surface of revolution can be determined without actually finding it. Only the evaluation of two simple algebraic expressions is involved. Should a specular point be found not to exist, a search procedure has been thereby...
Some existence and sufficient conditions of optimality
Assefi, T.
1976-01-01
The role of the existence and sufficiency conditions in the field of optimal control was briefly described. The existence theorems are discussed for general nonlinear systems. However, the sufficiency conditions pertain to "nearly" linear systems with integral convex costs. Moreover, a brief discussion of linear systems with multiple-cost functions is presented.
43 CFR 17.217 - Existing facilities.
2010-10-01
... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Existing facilities. 17.217 Section 17.217... facilities. (a) Accessibility. A recipient shall operate each program or activity so that when each part is... not require a recipient to make each of its existing facilities or every part of a facility...
Existence test for asynchronous interval iterations
Madsen, Kaj; Caprani, O.; Stauning, Ole
1997-01-01
In the search for regions that contain fixed points ofa real function of several variables, tests based on interval calculationscan be used to establish existence ornon-existence of fixed points in regions that are examined in the course ofthe search. The search can e.g. be performed...... as a synchronous (sequential) interval iteration:In each iteration step all components of the iterate are calculatedbased on the previous iterate. In this case it is straight forward to base simple interval existence and non-existencetests on the calculations done in each step of the iteration. The search can also...... be performed as an asynchronous (parallel) iteration: Only a few components are changed in each stepand this calculation is in general based on components from differentprevious iterates. For the asynchronous iteration it turns out thatsimple tests of existence and non-existence can be based...
Shang Yanying; Tang Chunlei
2007-01-01
This paper concerns the existence and multiplicity of solutions for some semilinear elliptic equations with critical Sobolev exponent,Hardy term and the sublinear nonlinearity at origin.By using Ekeland's variational principle,we conclude the existence of nontrivial solution for this problem,the Clark's critical point theorem is used to prove the existence of infinitely many solutions for this problem with odd nonlinearity.
Wykrzyknik - istnienie - zmiana (Exclamation - Existence - Change
Maciej Karpiński
2011-06-01
Full Text Available It, what exists, so to say, demands for the addressee – the thing exists in the face of (for something (or somebody. In other words, the existence is the relation. The competitive conception of the existence outside the relation (existence isolated leads to the contradiction. The existential proposition ‘Some A exists’, understoodliterally, is the pleonasm. It tends to treat the existential proposition as the conventional figure, expressing the simple act of an A affirmation (the exclamation ‘A!’. The existence’s relation should not be narrowed down only to the relation of perception(esse est percipi. It is needed to be understood widely, as every relation, in which something influences on whatever (that is, some change occurs. This influence (change can take place both inside or outside the consciousness. The existing thing, the influence exerted by it, and the change, occurred as the result of this influence, are identical. Thanks to it, we can eliminate difficulties connected withfinding ‘the point of contact’ between modules of the existence’s relation (that is, ‘the place’ where existing thing and its addressee are connected. The existence, as the relation of influence-change, is modal and gradual (as regards both intensity and extensiveness: the thing, in different aspects, can exist more or less. Theoretically, discussed relation can be symmetrical or antisymmetrical. The concept of error should be redefined. The error concerning the existence (resp. the nonexistence of specified thing, must not mean the incompatibility between this thing and the perception (widely: between this thing and the change causedby this thing in its addressee. The existence is the unity of the thing-perception (resp. the thing-influence-change. That is why the incompatibility can occur only between the state of thing-perception (resp. the thing-influence-change and the related state of duty. The conception of the existence as the relation
Existence theorems for ordinary differential equations
Murray, Francis J
2007-01-01
Theorems stating the existence of an object-such as the solution to a problem or equation-are known as existence theorems. This text examines fundamental and general existence theorems, along with the Picard iterants, and applies them to properties of solutions and linear differential equations.The authors assume a basic knowledge of real function theory, and for certain specialized results, of elementary functions of a complex variable. They do not consider the elementary methods for solving certain special differential equations, nor advanced specialized topics; within these restrictions, th
Physical Relativism as an Interpretation of Existence
Heinrich, Stuart
2013-01-01
Despite the success of modern physics in formulating mathematical theories that can predict the outcome of quantum-scale experiments, the physical interpretations of these theories remain controversial. In this manuscript, we propose a new interpretation of existence that we call physical relativism. Under physical relativism, the difference between mathematical existence and physical existence is clarified, and Wheeler's `it from bit' viewpoint can be objectively evaluated. In addition, physical relativism provides a simple answer to the question of why the universe exists at all, and permits us to derive the maximally biophilic principle, a generalization of the anthropic principle that ascribes high prior likelihood to the observation of a universe with simple physical laws supporting the overall concepts of time, space and the emergent evolution of life.
US Forest Service LANDFIRE Existing Vegetation
US Forest Service, Department of Agriculture — LANDFIRE Existing Vegetation is mapped using predictive landscape models based on extensive field-referenced data, satellite imagery and biophysical gradient layers...
LANDFIRE (90m) Existing Vegetation Type
U.S. Geological Survey, Department of the Interior — This map depicts the distribution of existing vegetation types contained in the LANDFIRE dataset. All 30-meter EVT grids were resampled to 90-meter grids and merged...
Pre-Existing Condition Insurance Plan Data
U.S. Department of Health & Human Services — The Affordable Care Act created the new Pre-Existing Condition Insurance Plan (PCIP) program to make health insurance available to Americans denied coverage by...
Do labour supply and demand curves exist?
Fleetwood, S.
2014-01-01
The objective of this paper is to show that circumstantial and empirical evidence for the existence of labour supply and demand curves is at best inconclusive and at worst casts doubt on their existence. Because virtually all orthodox models of labour markets, simple and complex, are built upon the foundation stones of labour supply and demand curves, these models lack empirically supported foundations. Orthodox labour economists must, therefore, either provide stronger evidence or stop using...
Constraint for the Existence of Ellipsoidal Vesicles
XIE Yu-Zhang
2000-01-01
Under the spontaneous curvature model of lipid bilayers, the constraints for the existence of equilibrium axisym metric oblate and prolate ellipsoidal vesicles are obtained from the general shape equation. They degenerate either to the constraint for the existence of a spherical vesicle or to that of a circular cylindrical vesicle given by Ou-Yang and Helfrich [Phys. Rev. Lett. 59 (1987) 2486; 60(1988)120; Phys. Rev. A 39 (1989) 5280].
Functional interpretation and the existence property
Jørgensen, Klaus Frovin
2004-01-01
It is shown that functional interpretation can be used to show the existence property of intuitionistic number theory. On the basis of truth variants a comparison is then made between realisability and functional interpretation showing a structural difference between the two.......It is shown that functional interpretation can be used to show the existence property of intuitionistic number theory. On the basis of truth variants a comparison is then made between realisability and functional interpretation showing a structural difference between the two....
Hidden Regular Variation: Detection and Estimation
Mitra, Abhimanyu
2010-01-01
Hidden regular variation defines a subfamily of distributions satisfying multivariate regular variation on $\\mathbb{E} = [0, \\infty]^d \\backslash \\{(0,0, ..., 0) \\} $ and models another regular variation on the sub-cone $\\mathbb{E}^{(2)} = \\mathbb{E} \\backslash \\cup_{i=1}^d \\mathbb{L}_i$, where $\\mathbb{L}_i$ is the $i$-th axis. We extend the concept of hidden regular variation to sub-cones of $\\mathbb{E}^{(2)}$ as well. We suggest a procedure of detecting the presence of hidden regular variation, and if it exists, propose a method of estimating the limit measure exploiting its semi-parametric structure. We exhibit examples where hidden regular variation yields better estimates of probabilities of risk sets.
Elsgolc, L E; Stark, M
1961-01-01
Calculus of Variations aims to provide an understanding of the basic notions and standard methods of the calculus of variations, including the direct methods of solution of the variational problems. The wide variety of applications of variational methods to different fields of mechanics and technology has made it essential for engineers to learn the fundamentals of the calculus of variations. The book begins with a discussion of the method of variation in problems with fixed boundaries. Subsequent chapters cover variational problems with movable boundaries and some other problems; sufficiency
Zhengxuan Jiang
Full Text Available PURPOSE: The aim of this study is to examine whether or not hepatocyte growth factor (HGF genetic variations are associated with susceptibility to primary angle-closure glaucoma (PACG in the Han Chinese population. METHODS: Three single-nucleotide polymorphisms (SNPs-rs5745718, rs17427817, and rs3735520-in the HGF gene were genotyped in 238 adult patients with PACG and 287 age-, sex-, and ethnically matched healthy controls by using a polymerase chain reaction restriction fragment length polymorphism assay. Data was analyzed by χ(2 analysis. RESULTS: The three tested analyzed polymorphisms in the HGF gene were in Hardy-Weinberg equilibrium, in all the subjects. The frequencies of the genotype and allele of rs5745718 and rs1742817 in the HGF gene were significantly different between the PACG patients and the controls. On one hand, the frequencies of the CC genotype and C allele of rs5745718 were significantly decreased in PACG patients compared with controls (Pc = 1.40×10(-3; Pc = 3.21×10(-4, respectively; however, on the other hand, significantly decreased frequencies of the GG genotype and the G allele of rs17427817 were observed in PACG patients compared with the controls (Pc = 0.006,; Pc = 6.06×10(-4, respectively. A comparison of the distributions of the genotypes and alleles of rs3735520 showed no statistically significant differences between the PACG patients and the controls (pc>0.05. The haplotype analysis results showed that the CGC haplotype frequency was significantly decreased in the patients with PACG compared with the controls (pc<0.001. No difference was detected between the patients and the controls with regard to the other haplotypes. CONCLUSIONS: Our study suggests that rs5745718 and rs17427817 are associated with a decreased risk of PACG in the Chinese Han population. The CGC haplotype was demonstrated to possibly play a protective role against PACG in this population.
A New Perturbed Algorithm for Generalized Quasi-Variational Inclusions
徐海丽; 郭兴明
2003-01-01
In this paper, a perturbed iterative method for solving a general class of quasi-variational inclusions was studied. The existence and convergence of solution were proved. Furthermore, a new iterative method for solving a general class of quasi-variational inclusions was proposed. The continuity of the perturbed solution was also proved for a parametric variational inclusion problem. Several special cases were discussed.
Ricardo Pérez-Enriquez
2011-09-01
Full Text Available In Mexico and elsewhere in the Caribbean, the queen conch Strombus gigas is an endangered species. Understanding the genetic connectivity of their populations will support management strategies for long term conservation of the species. Genetic diversity and population differentiation was assessed from samples collected at Banco Chinchorro and Isla Cozumel in the Mexican Caribbean and at Arrecife Alacranes in the Gulf of Mexico. Samples were obtained from the commercial capture at Banco Chinchorro (n=50 and Isla Cozumel (n=40 on March 2004. On November 2004, a non-invasive method for the Arrecife Alacranes sampling was applied, taking the hemolymph of live animals (n=65 and releasing them to the wild. The mitochondrial DNA variation at two genes (COI and Cyt-b was analyzed. Genetic diversity at the three locations ranged between 0.55-0.65 in COI and 0.87-0.94 in Cyt-b, showing no bottleneck evidences. A non-significant fixation index (F ST=0.019, p=0.161 and a Maximum Parsimony Network tree that did not show particular clades associated with any of the geographical locations, suggested a lack of statistically significant genetic differentiation among populations. Nevertheless, the cline patterns observed in both genetic diversity and haplotypic frequencies from Banco Chinchorro through Arrecife Alacranes, and the larger genetic distance between these locations from those between Isla Cozumel, Banco Chinchorro and Arrecife Alacranes, suggest the possibility of a pattern of isolation-by distance. The role of the main current systems over the potential genetic differences in S. gigas populations along the Mexican Caribbean, and the conservation management of S. gigas at these locations as discrete units is discussed. Rev. Biol. Trop. 59 (3: 1115-1126. Epub 2011 September 01.
Variational Splines and Paley--Wiener Spaces on Combinatorial Graphs
Pesenson, Isaac
2011-01-01
Notions of interpolating variational splines and Paley-Wiener spaces are introduced on a combinatorial graph G. Both of these definitions explore existence of a combinatorial Laplace operator onG. The existence and uniqueness of interpolating variational splines on a graph is shown. As an application of variational splines, the paper presents a reconstruction algorithm of Paley-Wiener functions on graphs from their uniqueness sets.
Variational Splines and Paley--Wiener Spaces on Combinatorial Graphs
Pesenson, Isaac
2011-01-01
Notions of interpolating variational splines and Paley-Wiener spaces are introduced on a combinatorial graph G. Both of these definitions explore existence of a combinatorial Laplace operator onG. The existence and uniqueness of interpolating variational splines on a graph is shown. As an application of variational splines, the paper presents a reconstruction algorithm of Paley-Wiener functions on graphs from their uniqueness sets.
A study of variational inequalities for set-valued mappings
Tarafdar Enayet
1999-01-01
Full Text Available In this paper, Ky Fan's KKM mapping principle is used to establish the existence of solutions for simultaneous variational inequalities. By applying our earlier results together with Fan–Glicksberg fixed point theorem, we prove some existence results for implicit variational inequalities and implicit quasi-variational inequalities for set-valued mappings which are either monotone or upper semi-continuous.
CZT imaging detectors for ProtoEXIST
Hong, J; Chammas, N; Copete, A; Baker, R G; Barthelmy, S D; Gehrels, N; Cook, W R; Burnham, J A; Harrison, F A; Collins, J; Craig, W W
2006-01-01
We describe the detector development for a balloon-borne wide-field hard X-ray (20 - 600 keV) telescope, ProtoEXIST. ProtoEXIST is a pathfinder for both technology and science of the proposed implementation of the Black Hole Finder Probe, Energetic X-ray Imaging Survey telescope (EXIST). The principal technology challenge is the development of large area, close-tiled modules of imaging CZT detectors (1000 cm2 for ProtoEXIST1). We review the updates of the detector design and package concept for ProtoEXIST1 and report the current development status of the CZT detectors, using calibration results of our basic detector unit - 2 x 2 x 0.5 cm CZT crystals with 2.5 mm pixels (8 x 8 array). The current prototype (Rev1) of our detector crystal unit (DCU) shows ~4.5 keV electronics noise (FWHM), and the radiation measurements show the energy resolution (FWHM) of the units is 4.7 keV (7.9%) at 59.5 keV, 5.6 keV (4.6%) at 122 keV, and 7.6 keV (2.1%) at 356 keV. The new (Rev2) DCU with revised design is expected to impro...
Objetos intencionais e existência objetiva
Jairo José da Silva
1991-12-01
Full Text Available Neste artigo quero apontar para a possibilidade de uma ontologia da matemática que, mesmo mantendo alguns pontos em comum com o platonismo e com o construtivismo, desliga-se destes em outros pontos essenciais. Por objeto matemático entendo o foco referencial do discurso matemático, ou seja, aquilo sobre o qual a matemática fala. Entendo que a existência destes objetos é meramente intencional, presuntiva, mas, simultaneamente, objetiva, no sentido de ser uma existência comunalizada, compartilhada por todos aqueles engajados no fazer matemático. A existência objetiva das entidades matemáticas não está, entretanto, garantida de uma vez por todas, mas apenas enquanto o discurso matemático for consistente. Este é o espírito do critério de existência objetiva enunciado que, acredito, deve sustentar uma ontologia matemática sem o pressuposto da existência independente de um domínio de objetos matemáticos, sem o empobrecimento que lhe impõem as diferentes versões construtivistas e sem a aniquilação que lhe infringe o formalismo sem objetos.
Existing bridge evaluation using deficiency point method
Vičan Josef
2016-01-01
Full Text Available In the transforming EU countries, transportation infrastructure has a prominent position in advancing industry and society. Recent developments show, that attention should be moved from the design of new structures towards the repair and reconstruction of existing ones to ensure and increase their satisfactory structural reliability and durability. The problem is very urgent because many construction projects, especially transport infrastructure, in most European countries are more than 50-60 years old and require rehabilitations based on objective evaluations. Therefore, the paper presents methodology of existing bridge evaluation based on reliability concept using Deficiency Point Method. The methodology was prepared from the viewpoint to determine the priority order for existing bridge rehabilitation.
On the existence of shortest directed networks
Swanepoel, Konrad J
2008-01-01
A directed network connecting a set A to a set B is a digraph containing an a-b path for each a in A and b in B. Vertices in the directed network not in A or B are called Steiner points. We show that in a finitely compact metric space in which geodesics exist, any two finite sets A and B are connected by a shortest directed network. We also bound the number of Steiner points by a function of the sizes of A and B. Previously, such an existence result was known only for the Euclidean plane [M. Alfaro, Pacific J. Math. 167 (1995) 201-214]. The main difficulty is that, unlike the undirected case (Steiner minimal trees), the underlying graphs need not be acyclic. Existence in the undirected case was first shown by E. J. Cockayne [Canad. Math. Bull. 10 (1967) 431-450].
Existence and Uniqueness in Shape from Shading
邓雁萍; 李价谷
1997-01-01
For the image of a smooth surface object fully contained within the field of view and illuminated in and arbitrary direction,this paper discusses the existence and uniqueness o the conditions for solving a shape-from-shading problem under the conditions that the Fourier series expansion of the image intensity contains only zero and first order terms in a polar coordinate system.Three theorems are established,one for the existence and two for the uniqueness of z-axis symmetric shape from shading.
Existence of a persistent background of turbulence
Vanzandt, T. E.
1983-01-01
A plausible scenario for the existence of a persistent back-ground of turbulence in the free atmosphere is described. The MST radar technique is the only existing technique that can be used to describe the morphology of occurrence of turbulence as a function of altitude, wind speed, shear, weather conditions, geographical location, etc. This technique was used also to assess the degree of universality of shape and amplitude of the buoyancy wave spectrum and the relation between the buoyancy wave spectrum and turbulence.
EXISTENCE OF OPTIMAL STRONG PARTIALLY BALANCED DESIGNS
Du Beiliang
2007-01-01
A strong partially balanced design SPBD(v, b, k; λ,0) whose b is the maximum number of blocks in all SPBD(v, b, k; λ, 0), as an optimal strong partially balanced design, briefly OSPBD(v, k, λ) is studied. In investigation of authentication codes it has been found that the strong partially balanced design can be used to construct authentication codes. This note investigates the existence of optimal strong partially balanced design OSPBD(v, k, 1) for k = 3and 4, and shows that there exists an OSPBD(v, k, 1) for any v ≥ k.
Does the Kuleshov Effect really Exist?
Barratt, Daniel; Cabak Rédei, Anna
2013-01-01
with a doll, a dead woman in a coffin, and a bowl of soup; the viewers of the three sequences were reported to have perceived Mozhukin’s face as expressing happiness, sadness, and hunger/thoughtfulness respectively. It is not clear, however, whether or not the socalled “Kuleshov effect” really exists...
Proof that chronic lyme disease exists.
Cameron, Daniel J
2010-01-01
The evidence continues to mount that Chronic Lyme Disease (CLD) exists and must be addressed by the medical community if solutions are to be found. Four National Institutes of Health (NIH) trials validated the existence and severity of CLD. Despite the evidence, there are physicians who continue to deny the existence and severity of CLD, which can hinder efforts to find a solution. Recognizing CLD could facilitate efforts to avoid diagnostic delays of two years and durations of illness of 4.7 to 9 years described in the NIH trials. The risk to society of emerging antibiotic-resistant organisms should be weighed against the societal risks associated with failing to treat an emerging population saddled with CLD. The mixed long-term outcome in children could also be examined. Once we accept the evidence that CLD exists, the medical community should be able to find solutions. Medical professionals should be encouraged to examine whether: (1) innovative treatments for early LD might prevent CLD, (2) early diagnosis of CLD might result in better treatment outcomes, and (3) more effective treatment regimens can be developed for CLD patients who have had prolonged illness and an associated poor quality of life.
Proof That Chronic Lyme Disease Exists
Daniel J. Cameron
2010-01-01
Full Text Available The evidence continues to mount that Chronic Lyme Disease (CLD exists and must be addressed by the medical community if solutions are to be found. Four National Institutes of Health (NIH trials validated the existence and severity of CLD. Despite the evidence, there are physicians who continue to deny the existence and severity of CLD, which can hinder efforts to find a solution. Recognizing CLD could facilitate efforts to avoid diagnostic delays of two years and durations of illness of 4.7 to 9 years described in the NIH trials. The risk to society of emerging antibiotic-resistant organisms should be weighed against the societal risks associated with failing to treat an emerging population saddled with CLD. The mixed long-term outcome in children could also be examined. Once we accept the evidence that CLD exists, the medical community should be able to find solutions. Medical professionals should be encouraged to examine whether: (1 innovative treatments for early LD might prevent CLD, (2 early diagnosis of CLD might result in better treatment outcomes, and (3 more effective treatment regimens can be developed for CLD patients who have had prolonged illness and an associated poor quality of life.
EXISTENCE TIME FOR THE SEMILINEAR SCHROEDINGER EQUATION
WeiMingjun
2003-01-01
Based on the methods introduced by Klainerman and Ponce.and Cohn.a lower bounded estimate of the existence time for a kind of semilinear Schroedinger equation is obtained in this paper.The implemantation of this method depends on the Lp-Lq estimate and the energy estimate.
THE EXISTENCE THEOREM OF OPTIMAL GROWTH MODEL
Gong Liutang; Peng Xianze
2005-01-01
This paper proves a general existence theorem of optimal growth theory. This theorem is neither restricted to the case of a constant technology progress, nor stated in terms of mathematical conditions which have no direct economic interpretation and moreover, are difficult to apply.
Modeling Truth Existence in Truth Discovery.
Zhi, Shi; Zhao, Bo; Tong, Wenzhu; Gao, Jing; Yu, Dian; Ji, Heng; Han, Jiawei
2015-08-01
When integrating information from multiple sources, it is common to encounter conflicting answers to the same question. Truth discovery is to infer the most accurate and complete integrated answers from conflicting sources. In some cases, there exist questions for which the true answers are excluded from the candidate answers provided by all sources. Without any prior knowledge, these questions, named no-truth questions, are difficult to be distinguished from the questions that have true answers, named has-truth questions. In particular, these no-truth questions degrade the precision of the answer integration system. We address such a challenge by introducing source quality, which is made up of three fine-grained measures: silent rate, false spoken rate and true spoken rate. By incorporating these three measures, we propose a probabilistic graphical model, which simultaneously infers truth as well as source quality without any a priori training involving ground truth answers. Moreover, since inferring this graphical model requires parameter tuning of the prior of truth, we propose an initialization scheme based upon a quantity named truth existence score, which synthesizes two indicators, namely, participation rate and consistency rate. Compared with existing methods, our method can effectively filter out no-truth questions, which results in more accurate source quality estimation. Consequently, our method provides more accurate and complete answers to both has-truth and no-truth questions. Experiments on three real-world datasets illustrate the notable advantage of our method over existing state-of-the-art truth discovery methods.
Repurposing Existing Material for Performance Support.
Harvey, Francis A.; Nelson, Adam
1995-01-01
Presents an overview of performance support systems (PSS), describes their role in promoting productivity in agile organizations, and discusses issues related to developing effective performance support using existing orientation, training, or procedural manuals. Topics include strategic principles of agility, and adding value when incorporating…
36 CFR 9.33 - Existing operations.
2010-07-01
... MINERALS MANAGEMENT Non-Federal Oil and Gas Rights § 9.33 Existing operations. (a) Any person conducting... (within thirty (30) days of January 8, 1979), notifies the Superintendent in writing of the nature and... reasons for the suspension and of his right to appeal the suspension under § 9.48. ...
Foucault, Counselling and the Aesthetics of Existence
Peters, Michael A.
2005-01-01
Michel Foucault was drawn late in life to study the "arts of the self" in Greco-Roman culture as a basis, following Nietzsche, for what he called an "aesthetics of existence." By this, he meant a set of creative and experimental processes and techniques by which an individual turns him- or herself into a work of art. For Nietzsche, it was above…
Foucault, Counselling and the Aesthetics of Existence
Peters, Michael A.
2005-01-01
Michel Foucault was drawn late in life to study the "arts of the self" in Greco-Roman culture as a basis, following Nietzsche, for what he called an "aesthetics of existence." By this, he meant a set of creative and experimental processes and techniques by which an individual turns him- or herself into a work of art. For Nietzsche, it was above…
Psychology's struggle for existence: Second edition, 1913.
Wundt, Wilhelm; Lamiell, James T
2013-08-01
Presents an English translation of Wilhelm Wundt's Psychology's struggle for existence: Second edition, 1913, by James T. Lamiell in August, 2012. In his essay, Wundt advised against the impending divorce of psychology from philosophy. (PsycINFO Database Record (c) 2013 APA, all rights reserved).
Vocation as the Quest for Authentic Existence.
Homan, Kenneth B.
1986-01-01
Examines the concept of vocation and demonstrates that vocation is the organizing, existential principle of the concept of work. Presents a critical examination of Green's (1968) delineation of job and work and asserts that vocation as the quest for authentic existence is the unifying concept that gives grounding to Green's notion of work. (NB)
Reliability Analysis of Existing Vertical Wall Breakwaters
Burcharth, H. F.; Sørensen, John Dalsgaard
1998-01-01
Vertical wall breakwaters are used under quite different conditions where failure of the breakwater or a part of it will have very different consequences. Further a number of existing vertical wall breakwaters have been subjected to significant wave loads which have caused partial failures...
Existence and Stability of Solutions for Implicit Multivalued Vector Equilibrium Problems
Li Qiuying
2011-01-01
Full Text Available A class of implicit multivalued vector equilibrium problems is studied. By using the generalized Fan-Browder fixed point theorem, some existence results of solutions for the implicit multivalued vector equilibrium problems are obtained under some suitable assumptions. Moreover, a stability result of solutions for the implicit multivalued vector equilibrium problems is derived. These results extend and unify some recent results for implicit vector equilibrium problems, multivalued vector variational inequality problems, and vector variational inequality problems.
Functions of bounded variation
Lind, Martin
2006-01-01
The paper begins with a short survey of monotone functions. The functions of bounded variation are introduced and some basic properties of these functions are given. Finally the jump function of a function of bounded variation is defined.
Janssen, B.; van Kranenburg, P.
2014-01-01
Variation in music can be caused by different phenomena: conscious, creative manipulation of musical ideas; but also unconscious variation during music recall. It is the latter phenomenon that we wish to study: variation which occurs in oral transmission, in which a melody is taught without the help
Janssen, B.; van Kranenburg, P.
2014-01-01
Variation in music can be caused by different phenomena: conscious, creative manipulation of musical ideas; but also unconscious variation during music recall. It is the latter phenomenon that we wish to study: variation which occurs in oral transmission, in which a melody is taught without the help
Overview of Existing Wind Energy Ordinances
Oteri, F.
2008-12-01
Due to increased energy demand in the United States, rural communities with limited or no experience with wind energy now have the opportunity to become involved in this industry. Communities with good wind resources may be approached by entities with plans to develop the resource. Although these opportunities can create new revenue in the form of construction jobs and land lease payments, they also create a new responsibility on the part of local governments to ensure that ordinances will be established to aid the development of safe facilities that will be embraced by the community. The purpose of this report is to educate and engage state and local governments, as well as policymakers, about existing large wind energy ordinances. These groups will have a collection of examples to utilize when they attempt to draft a new large wind energy ordinance in a town or county without existing ordinances.
Existence of Multiagent Equilibria with Limited Agents
Bowling, M; 10.1613/jair.1332
2011-01-01
Multiagent learning is a necessary yet challenging problem as multiagent systems become more prevalent and environments become more dynamic. Much of the groundbreaking work in this area draws on notable results from game theory, in particular, the concept of Nash equilibria. Learners that directly learn an equilibrium obviously rely on their existence. Learners that instead seek to play optimally with respect to the other players also depend upon equilibria since equilibria are fixed points for learning. From another perspective, agents with limitations are real and common. These may be undesired physical limitations as well as self-imposed rational limitations, such as abstraction and approximation techniques, used to make learning tractable. This article explores the interactions of these two important concepts: equilibria and limitations in learning. We introduce the question of whether equilibria continue to exist when agents have limitations. We look at the general effects limitations can have on agent b...
Gambling on the existence of other universes
Sangalli, Arturo
2016-01-01
Speculations and theories about the existence of other worlds have a long history. In recent times, the arguments have shifted away from their typical philosophical and theological character to supposedly become more objective thanks to their scientific underpinnings. A prime example of this is the current parallel universes or multiverse theory, which has the support of a number of famous cosmologists. In this article, we contend that the claim for the existence of those parallel universes, as presented in Max Tegmark's book "Our Mathematical Universe", rests crucially on some questionable probability arguments involving infinity. As a result, a doubt is cast over the multiverse hypothesis: Is it more credible than the counterarguments based on philosophical and metaphysical considerations?
LOVE’S SYMPHONY: MULTIPLICITY OF EXISTENCE
CHRISTINE McNEILL-MATTESON
2016-05-01
Full Text Available Love, although universal in thought, is explicitly complex and articulately multi-defined in almost every idea and expression. Love written is timeless from the molecules we possess within us, to the cosmos we study and explore. We can only exist and continue to exist in harmony with creation. Harmony reaches far beyond galaxies and universes, flowing backinto the most separate of the smallest molecules. Within all common denominators of harmony there is love: the very catalyst of harmony itself. This paper will look at harmony from a poetic point of view and examine how it is expressed always in the context of the mystery of sentience and conscience from human biology to the divine cosmos
On the existence of MSA coordinates
Hernández-Pastora, J L
2009-01-01
The static solutions of the axially symmetric vacuum Einstein equations with a finite number of Relativistic Multipole Moments are described by means of a function that can be written in the same analytic form as the Newtonian gravitational multipole potential. A family of so-called MSA (Multipole-Symmetry Adapted) coordinates are introduced and calculated at any multipole order to perform the transformation of the Weyl solutions. In analogy with a previous result obtained in Newtonian gravity, the existence of a symmetry of a certain system of differential equations leading to the determination of that kind of multipole solutions in General Relativity is explored. The relationship between the existence of this kind of coordinate and the symmetries mentioned is proved for some cases, and the characterization of the MSA system of coordinates by means of this relationship is discussed.
Co-existence of agricultural production systems.
Jank, Bernhard; Rath, Johannes; Gaugitsch, Helmut
2006-05-01
Strategies and best practices for the co-existence of GM and non-GM crops need to be developed and implemented with the participation of farmers and other stakeholders. According to the principle of 'subsidiarity', decisions should be made by the lowest authority possible. When applying this concept to the case of GM crops, the affected society should determine their use and management in a regional decision-making process. Public participation is better accomplished at a lower level, and democratic deficits in decision-making on GMOs are better resolved, enabling farmers to manage or avoid GM crops. Ultimately, voluntary GMO-free zones might be a tool for sustainable co-existence and GM-free production and GMO-free zones might create a specific image for marketing regional products and services, such as tourism.
Implementation of ventilation in existing schools
Hviid, Christian Anker; Petersen, Steffen
Present paper analyses the best-practice solutions for classrooms’ ventilation that fit the objective of quick and inexpensive implementation. The paper decomposes the relations between ventilation and building into manageable elements and analyzes them. The analyses are performed qualitatively......; they evaluate both scientific and practical implementation The analyses lead to a list of criteria associated with the implementation of ventilation in existing schools. Generic retrofitting scenarios which prioritize energy savings, indoor climate and building/facade integration are assembled and illustrated...
Existence results for a class of nonlocal problems involving p-Laplacian
Zhang Jihui
2011-01-01
Full Text Available Abstract This paper is concerned with the existence of solutions to a class of p-Kirchhoff type equations with Neumann boundary data as follows: - M ∫ Ω ∇ u p d x p - 1 Δ p u = f ( x , u , in Ω ; ∂ u ∂ υ = 0 , on ∂ Ω . By means of a direct variational approach, we establish conditions ensuring the existence and multiplicity of solutions for the problem.
Existence results for a class of nonlocal problems involving p-Laplacian
Zhang Jihui; Yang Yang
2011-01-01
Abstract This paper is concerned with the existence of solutions to a class of p-Kirchhoff type equations with Neumann boundary data as follows: - M ∫ Ω ∇ u p d x p - 1 Δ p u = f ( x , u ) , in Ω ; ∂ u ∂ υ = 0 , on ∂ Ω . By means of a direct variational approach, we establish conditions ensuring the existence and multiplicity of solutions for the problem.
Eifler, Tobias; Boorla, Srinivasa Murthy; Howard, Thomas J.
2016-01-01
a lack of objective variation data in design. As a result, variation analyses and tolerancing activities rely on numerous assumptions made to fill the gaps of missing or incomplete data. To overcome this hidden subjectivity, a schema for a consistent and standardised description of manufacturing......The need to mitigate the effects of manufacturing variation already in design is nowadays commonly acknowledged and has led to a wide use of predictive modeling techniques, tolerancing approaches, etc. in industry. The trustworthiness of corresponding variation analyses is, however, not ensured...... variation is suggested. It extends existing ISO GPS annotation by information about influences on the manufacturability of a chosen design solution and in this way enables the systematic acquisition of variation data meaningful for design practice....
Valdarsky, Irit Hameiri
2015-10-01
This paper attempts to distil out a particular quality of psychic (non)existence, which I call here 'void existence', from the quality predominantly explored in the psychoanalytic discourse on primitive mental states, which I call 'annihilation existence'. Achieving this phenomenological differentiation may make it easier to identify and work through extreme states in the analytic situation, when the patient is under the dominance of 'void existence'. I suggest that it is, as it were, a one-dimensional existence, in an infinite contour-less void, lacking any substantial internal object, lacking any substantial sense of psychic and/or somatic occurrences, and lacking any live representation of this very state of being. Hence, it lacks distress and anxiety, as well as calmness and peace. One might say that it is the inorganic within the organic; a quality of non-alive-ness within life. 'Annihilation existence' is existence in a two- or three-dimensional hollowed world, with flat and/or partial representations of self and object, which attracts acute distress and annihilation anxiety. It is a sort of existence on the brink of non-life, on the brink of the void; where a sense of catastrophic danger is brought on by the never-ending potentiality of the annihilation's realization. Both these psychic qualities can be encapsulated within neurotic and personality disorders, and the dominance of each can serve as defence against the dominance of the other. The theoretical discussion is supported by excerpts from an analysis.
Sustainability in the existing building stock
Elle, Morten; Nielsen, Susanne Balslev; Hoffmann, Birgitte
2005-01-01
management is a concept relevant to others than large companies. Managing the flows of energy and other resources is a part of facilities management, and an increased professionalism could lead to the reduction of the use of energy and water and the generation of waste and wastewater. This is, however...... sustainable building. In other words: the question is if it sensible to talk about a ‘sustainable building’ without taking the activities in the building into account? In many contexts, maintenance of the existing building stock is not a hot political topic. Facilities management can, however, be a vehicle...
Existing cometary data and future needs
Rahe, J.
1981-10-01
To assist scientists studying comets and their interaction with the interplanetary medium, compilations of existing cometary observations and data plans for additional publication are reported. The works cited include updates and/or supplements to: (1) the Catalogue of Cometary Orbits, (2) Physical Characteristics of Comets, (3) the Atlas of Representative Cometary Spectra, (4) the Atlas Cometas-Viento Solar, (5) the Isophotometrischer Atlas der Kometen, and (6) the Atlas of Cometary Forms. An Atlas of Cometary Spectra and an Atlas of Comet Halley 1910 (II) photographs and spectra are in preparation.
Energy Savings Measure Packages: Existing Homes
Casey, S.; Booten, C.
2011-11-01
This document presents the most cost effective Energy Savings Measure Packages (ESMP) for existing mixed-fuel and all electric homes to achieve 15% and 30% savings for each BetterBuildings grantee location across the US. These packages are optimized for minimum cost to homeowners for given source energy savings given the local climate and prevalent building characteristics (i.e. foundation types). Maximum cost savings are typically found between 30% and 50% energy savings over the reference home. The dollar value of the maximum annual savings varies significantly by location but typically amounts to $300 - $700/year.
Leibniz on the existence of atoms
Ricardo Mena
Full Text Available ABSTRACT In this paper I present and evaluate Leibniz’s two main arguments against the existence of atoms. In this context atoms are extended particles that are absolutely hard, homogeneous, indivisible, and indestructible by natural means. As we shall see, Leibniz’s arguments are flawed in a very instructive way. The first argument is in tension with the claim that God created the best possible world. The second argument overgeneralizes in an undesirable way. However, as I shall discuss in the last section of the paper, even if the arguments are somehow defective, at least the first one contributes valuable insights to contemporary metaphysics.
Does the Kuleshov Effect really Exist?
Barratt, Daniel; Cabak Rédei, Anna
2013-01-01
movements were recorded throughout the experiment using a remote eye-tracker (SMI iView X RED). A preliminary analysis of the results suggests that some sort of Kuleshov effect does in fact exist. For the different emotional conditions, the participants tended to choose the appropriate emotion more......, sadness, and hunger/neutral conditions with equivalent stimuli. For each film sequence, the participant was asked: to rate the valence of the depicted person’s emotion; to rate how aroused the person appeared to be; and to identify the type of emotion that the person was feeling. The participant’s eye...
Energy Savings Measure Packages. Existing Homes
Casey, Sean [National Renewable Energy Lab. (NREL), Golden, CO (United States); Booten, Chuck [National Renewable Energy Lab. (NREL), Golden, CO (United States)
2011-11-01
This document presents the most cost effective Energy Savings Measure Packages (ESMP) for existing mixed-fuel and all electric homes to achieve 15% and 30% savings for each BetterBuildings grantee location across the United States. These packages are optimized for minimum cost to homeowners for source energy savings given the local climate and prevalent building characteristics (i.e. foundation types). Maximum cost savings are typically found between 30% and 50% energy savings over the reference home; this typically amounts to $300 - $700/year.
EXIST Mission Design Concept and Technology Program
Grindlay, J E; Gehrels, N; Harrison, F A; Hong, J
2002-01-01
The Energetic X-ray Imaging Survey Telescope (EXIST) is a proposed very large area coded aperture telescope array, incorporating 8m^2 of pixellated Cd-Zn-Te (CZT) detectors, to conduct a full-sky imaging and temporal hard x-ray (10-600 keV) survey each 95min orbit. With a sensitivity (5sigma, 1yr) of ~0.05mCrab (10-150 keV), it will extend the ROSAT soft x-ray (0.5-2.5keV) and proposed ROSITA medium x-ray (2-10 keV) surveys into the hard x-ray band and enable identification and study of sources ~10-20X fainter than with the ~15-100keV survey planned for the upcoming Swift mission. At ~100-600 keV, the ~1mCrab sensitivity is 300X that achieved in the only previous (HEAO-A4, non-imaging) all-sky survey. EXIST will address a broad range of key science objectives: from obscured AGN and surveys for black holes on all scales, which constrain the accretion history of the universe, to the highest sensitivity and resolution studies of gamma-ray bursts it will conduct as the Next Generation Gamma-Ray Burst mission. We ...
Grindlay, J E
2004-01-01
The Energetic X-ray Timing Survey Telescope (EXIST) mission concept is under study as the Black Hole Finder Probe (BHFP), one of the three Einstein Probe missions in the Beyond Einstein Program in the current NASA Strategic Plan. EXIST would conduct an all-sky imaging hard X-ray ($\\sim$10-600 keV) survey with unprecedented sensitivity: about 5 $\\times 10^{-13}$ cgs over any factor of 2 bandwidth, or comparable to that achieved at soft X-rays in the ROSAT survey. The proposed angular resolution of 5arcmin, temporal resolution of 10microsec, energy resolution of 1-4 keV over the broad band, and duty cycle of 0.2-0.5 for continuous coverage of any source provide an unprecedented phase space for timing and spectral studies of black holes --from stellar to supermassive, as well as neutron stars and accreting white dwarfs. The large sky coverage allows intrinsically rare events to be studied. One particularly exciting example is the possible detection of tidal disruption of stars near quiescent AGN. Super flares fr...
Overview of EXIST mission science and implementation
Grindlay, J; Bloom, J; Coppi, P; Soderberg, A; Hong, J; Allen, B; Barthelmy, S; Tagliaferri, G; Moseley, H; Kutyrev, A; Fabbiano, G; Fishman, G; Ramsey, B; Della Ceca, R; Natalucci, L; Ubertini, P
2010-01-01
The Energetic X-ray Imaging Survey Telescope (EXIST) is designed to i) use the birth of stellar mass black holes, as revealed by cosmic Gamma-Ray Bursts (GRBs), as probes of the very first stars and galaxies to exist in the Universe. Both their extreme luminosity (~104 times larger than the most luminous quasars) and their hard X-ray detectability over the full sky with wide-field imaging make them ideal "back-lights" to measure cosmic structure with X-ray, optical and near-IR (nIR) spectra over many sight lines to high redshift. The full-sky imaging detection and rapid followup narrow-field imaging and spectroscopy allow two additional primary science objectives: ii) novel surveys of supermassive black holes (SMBHs) accreting as very luminous but rare quasars, which can trace the birth and growth of the first SMBHs as well as quiescent SMBHs (non-accreting) which reveal their presence by X-ray flares from the tidal disruption of passing field stars; and iii) a multiwavelength Time Domain Astrophysics (TDA) s...
Existence of frozen-in coordinate systems
Chertkov, A. D.
1995-01-01
The 'frozen-in' coordinate systems were first introduced in the works on 'reconnection' and 'magnetic barrier' theories (see review by M.l.Pudovkin and V.S.Semenov, Space Sci. Rev. 41,1 1985). The idea was to utilize the mathematical apparatus developed for 'general relativity' theory to simplify obtaining solutions to the ideal MHD equations set. Magnetic field (B), plasma velocity (v), and their vector product were used as coordinate vectors. But there exist no stationary solutions of ideal MHD set that satisfies the required boundary conditions at infinity (A.D.Chertkov, Solar Wind Seven Conf.,Pergamon Press,1992,165) having non-zero vector product of v and B where v and B originate from the same sphere. The existence of a solution is the hidden mine of the mentioned theories. The solution is constructed in the coordinate system, which is unknown and indeterminate before obtaining this solution. A substitution of the final solution must be done directly into the initial MHD set in order to check the method. One can demonstrate that 'solutions' of Petschek's problem, obtained by 'frozen-in' coordinate systems, does not satisfy just the 'frozen-in' equation, i.e. induction equation. It stems from the fact that Petschek's 're-connection' model, treated as a boundary problem, is over determined. This problem was incorrectly formulated.
Surveying the Extreme Sky with EXIST
Grindlay, Jonathan E
2010-01-01
The recent hard X-ray surveys performed by INTEGRAL and Swift have started to reveal the demographics of compact sources including Super-Massive Black Holes hosted in AGNs and have proven invaluable in tracking explosive events as the death of massive stars revealed by Gamma-Ray Bursts up to cosmological distances. Whereas the observations have contributed significantly to our understanding of the sources populations in the Local Universe, it has also become evident that revealing the processes that drive the birth and evolution of the first massive stars and galaxies would have required a further big step in both sensitivity and capability to study transient phenomena since their very beginning and covering different wavebands simultaneously. Therefore, after its decennial history as a proposed hard X-ray survey mission, EXIST has now turned into a new, more advanced concept with three instruments on board covering the IR/optical and X-ray/soft gamma-ray bands. The EXIST new design (Grindlay 2009a) is theref...
Existence families, functional calculi and evolution equations
deLaubenfels, Ralph
1994-01-01
This book presents an operator-theoretic approach to ill-posed evolution equations. It presents the basic theory, and the more surprising examples, of generalizations of strongly continuous semigroups known as 'existent families' and 'regularized semigroups'. These families of operators may be used either to produce all initial data for which a solution in the original space exists, or to construct a maximal subspace on which the problem is well-posed. Regularized semigroups are also used to construct functional, or operational, calculi for unbounded operators. The book takes an intuitive and constructive approach by emphasizing the interaction between functional calculus constructions and evolution equations. One thinks of a semigroup generated by A as etA and thinks of a regularized semigroup generated by A as etA g(A), producing solutions of the abstract Cauchy problem for initial data in the image of g(A). Material that is scattered throughout numerous papers is brought together and presented in a fresh, ...
SENSITIVITY ANALYSIS FOR PARAMETERIZED VARIATIONAL INEQUALITY PROBLEMS
Li Fei
2004-01-01
This paper presents sensitivity analysis for parameterized variational inequality problems (VIP). Under appropriate assumption, it is shown that the perturbed solution to parameterized VIP is existent, unique, continuous and differentiable with respect to perturbation parameter. In the case of differentiability, we derive the equations forcalculating the derivative of solution variables with respect to the perturbation parameters.
Explaining Variation in Child Labor Statistics
Dillon, Andrew; Bardasi, Elena; Beegle, Kathleen; Serneels, Pieter
2010-01-01
Child labor statistics are critical for assessing the extent and nature of child labor activities in developing countries. In practice, widespread variation exists in how child labor is measured. Questionnaire modules vary across countries and within countries over time along several dimensions, including respondent type and the structure of the questionnaire. Little is known about the eff...
Dirichlet Form of Product of Variational Fractals
刘源
2003-01-01
Much effort has gone into constructing Dirichlet forms to define Laplacians on self-similar sets. However, the results have only been successful on p.c.f. (post critical finite) fractals. We prove the existence of a Dirichlet form on a class of non-p.c.f. sets that are the product of variational fractals.
Partial differential equations and calculus of variations
Leis, Rolf
1988-01-01
This volume contains 18 invited papers by members and guests of the former Sonderforschungsbereich in Bonn (SFB 72) who, over the years, collaborated on the research group "Solution of PDE's and Calculus of Variations". The emphasis is on existence and regularity results, on special equations of mathematical physics and on scattering theory.
Hannah MOULE; Kirilee CHAPLIN; Rebecca D BRAY; Kimberly A MILLER; Michael B THOMPSON; David G CHAPPLE
2015-01-01
Invasive species are considered one of the greatest threats to native ecosystems, second only to habitat loss and frag-mentation. Despite this, the temporal dynamics of invasions are poorly understood, with most studies focusing on a single time point, providing us with only a snapshot of the biology and genetics of the invader. We investigated the invasion of Lord Howe Island by the delicate skinkLampropholis delicata and assessed the introduction history and genetic structure of this species over a 5-year period. Using genetic data taken from 2007, and again in 2011/12, we examined changes in the population genetic struc-ture (whether new haplotypes had been introduced to the island, and shifts in haplotype frequencies) of the species on the island between these two time points. No new haplotypes were introduced to the island between 2007 and 2011/12; however, significant shifts in haplotype frequencies across the island were detected. We conclude that the delicate skink is expanding its range into the southern regions of the island and that the haplotype frequencies on Lord Howe Island are still in a state of highly dynamic flux. Our study highlights the importance of considering invasions as dynamic and studying them in such a way that enable us to better manage their impacts [Current Zoology 61 (3): 456–464, 2015].
Variation of fundamental constants
Flambaum, V V
2006-01-01
We present a review of recent works devoted to the variation of the fine structure constant alpha, strong interaction and fundamental masses. There are some hints for the variation in quasar absorption spectra, Big Bang nucleosynthesis, and Oklo natural nuclear reactor data. A very promising method to search for the variation of the fundamental constants consists in comparison of different atomic clocks. Huge enhancement of the variation effects happens in transition between accidentally degenerate atomic and molecular energy levels. A new idea is to build a ``nuclear'' clock based on the ultraviolet transition between very low excited state and ground state in Thorium nucleus. This may allow to improve sensitivity to the variation up to 10 orders of magnitude! Huge enhancement of the variation effects is also possible in cold atomic and molecular collisions near Feschbach resonance.
Alain Mignot
2005-09-01
Full Text Available This paper shows the existence of a solution of the quasi-static unilateral contact problem with nonlocal friction law for nonlinear elastic materials. We set up a variational incremental problem which admits a solution, when the friction coefficient is small enough, and then by passing to the limit with respect to time we obtain a solution.
Sharp Criterion of Global Existence for Nonlinear Schr(o)dinger Equation with a Harmonic Potential
Ji SHU; Jian ZHANG
2009-01-01
This paper discusses nonlinear Schr(o)dinger equation with a harmonic potential. By constructing a different cross-constrained variational problem and the so-called invariant sets, we derive a new threshold for blow-up and global existence of solutions.
Existence of three solutions for impulsive nonlinear fractional boundary value problems
Shapour Heidarkhani
2017-01-01
Full Text Available In this work we present new criteria on the existence of three solutions for a class of impulsive nonlinear fractional boundary-value problems depending on two parameters. We use variational methods for smooth functionals defined on reflexive Banach spaces in order to achieve our results.
Gelfand, I M
2000-01-01
Based on a series of lectures given by I. M. Gelfand at Moscow State University, this book actually goes considerably beyond the material presented in the lectures. The aim is to give a treatment of the elements of the calculus of variations in a form both easily understandable and sufficiently modern. Considerable attention is devoted to physical applications of variational methods, e.g., canonical equations, variational principles of mechanics, and conservation laws.The reader who merely wishes to become familiar with the most basic concepts and methods of the calculus of variations need on
On the existence of stationary Ricci solitons
Figueras, Pau
2016-01-01
Previously the DeTurck 'trick' has been used to render the stationary Einstein's equation a well posed elliptic system that may be solved numerically by geometric flow or directly. Whilst in the static case for pure gravity with zero or negative cosmological constant there is a simple proof that solving the modified "harmonic" Einstein's equation leads to a solution of the original Einstein system - i.e. not a Ricci soliton - in the stationary case this argument no longer works. Here we provide a new argument that extends the static result to the case of stationary spacetimes that possess a "$t$-$\\phi$" reflection symmetry. Defining a "soliton charge" from the asymptotic behaviour of the solution, we show that this quantity is always non-positive. Provided asymptotic conditions are chosen such that this charge vanishes, then stationary solitons cannot exist.
Existence of six-$\\alpha$ linear structure
Iwata, Yoritaka; Itagaki, Naoyuki; Maruhn, Joachim A; Otsuka, Takaharu
2014-01-01
The stable existence of a six-$\\alpha$ linear structure in highly excited states of $^{24}$Mg is studied based on a systematic Cranked Hartree-Fock calculation with various Skyrme-type interactions. Its stability is examined by allowing the transition of the cluster structure to the shell-model like structure. Especially, the six-$\\alpha$ linear state is exposed to two major instabilities: the bending motion, which is the main path for the transition to low-lying states, and the spin-orbit interaction, which is the driving force to break the $\\alpha$ clusters and enhance the independent motion of the nucleons. The linear structure with large angular momentum is obtained as a meta-stable stationary state.
Welfare Economics: A Story of Existence
Khalid Iqbal
2017-06-01
Full Text Available The purpose of this study is to explore that, despite severe challenges, welfare economics still exists. This descriptive study is conducted through some specific time line developments in this field. Economists are divided over the veracity and survival of the welfare economics. Welfare economics emphasizes on the optimum resource and goods allocation with the objective of better living standard, materialistic gains, social welfare and ethical decisions. It origins back to the political economics and utilitarianism. Adam Smith, Irving Fisher and Pareto contributed significantly towards it. During 1930 to 1940, American and British approaches were developed. Many economists tried to explore the relationship between level of income and happiness. Amartya Sen gave the comparative approach and Tinbergen pioneered the theory of equity. Contemporarily the futuristic restoration of welfare economics is on trial and hopes are alive. This study may be useful to understand the transitional and survival process of welfare economics.
On the existence of Levi Foliations
RENATA N. OSTWALD
2001-03-01
Full Text Available Let L be a real 3 dimensional analytic variety. For each regular point p L there exists a unique complex line l p on the space tangent to L at p. When the field of complex line p l p is completely integrable, we say that L is Levi variety. More generally; let L M be a real subvariety in an holomorphic complex variety M. If there exists a real 2 dimensional integrable distribution on L which is invariant by the holomorphic structure J induced by M, we say that L is a Levi variety. We shall prove: Theorem. Let be a Levi foliation and let be the induced holomorphic foliation. Then, admits a Liouvillian first integral. In other words, if is a 3 dimensional analytic foliation such that the induced complex distribution defines an holomorphic foliation ; that is, if is a Levi foliation; then admits a Liouvillian first integral--a function which can be constructed by the composition of rational functions, exponentiation, integration, and algebraic functions (Singer 1992. For example, if f is an holomorphic function and if theta is real a 1-form on ; then the pull-back of theta by f defines a Levi foliation : f*theta = 0 which is tangent to the holomorphic foliation : df = 0. This problem was proposed by D. Cerveau in a meeting (see Fernandez 1997.Seja L Ì uma variedade real de dimensão 3. Para todo ponto regular p Î L existe uma única reta complexa l p no espaço tangente à L em p. Quando o campo de linhas complexas p l p é completamente integrável, dizemos que L é uma variedade de Levi. Mais geralmente, seja L Ì M uma subvariedade real em uma variedade analítica complexa. Se existe uma distribuição real integrável de dimensão 2 em L que é invariante pela estrutura holomorfa J induzida pela variedade complexa M, dizemos que L é uma variedade de Levi. Vamos provar: Teorema. Seja uma folheação de Levi e seja a folheação holomorfa induzida. Então tem integral primeira Liouvilliana. Em outras palavras, se é uma folheação real de
Sustainability in the existing building stock
Jensen, Jesper Ole
2005-01-01
This paper explores the role of Facilities Management in the relation to sustainable development in the existing building stock. Facilities management is a concept still developing as the management of buildings are becoming more and more professional. Many recognize today that facilities...... management is a concept relevant to others than large companies. Managing the flows of energy and other resources is a part of facilities management, and an increased professionalism could lead to the reduction of the use of energy and water and the generation of waste and wastewater. This is, however......, QRWfacilities management’s most important contribution to sustainable development in the built environment. Space management is an essential tool in facilities management – and it could be considered a powerful tool in sustainable development; remembering that the building not being built is perhaps the most...
Testing Metadata Existence of Web Map Services
Jan Růžička
2011-05-01
Full Text Available For a general user is quite common to use data sources available on WWW. Almost all GIS software allow to use data sources available via Web Map Service (ISO/OGC standard interface. The opportunity to use different sources and combine them brings a lot of problems that were discussed many times on conferences or journal papers. One of the problem is based on non existence of metadata for published sources. The question was: were the discussions effective? The article is partly based on comparison of situation for metadata between years 2007 and 2010. Second part of the article is focused only on 2010 year situation. The paper is created in a context of research of intelligent map systems, that can be used for an automatic or a semi-automatic map creation or a map evaluation.
The enhancement of existing DES Maplet interface
Abdullah, Nur Lina; Mutalip, Rasidah Abdull; Abdullah, Kamilah
2014-07-01
This study pertains to the process of Data Encryption Standard, DES. DES consists of encryption and decryption processes linked with mathematical elements such as algebra and number theory. Preliminary, studies revealed that most of mathematics students face a problem in understanding the complicated process of DES. In modern learning methods, learning environment becomes more interesting with the use of computer and a variety of mathematical software packages. Several mathematical softwares such as Maple, Mathematica, Mathlab and Sage were developed in order to fulfill the specific calculation requirements. Correspondingly, motivated from that, this study incorporated with Maple to enhance the existing DES Maplet interface to be more interactive and user-friendly compared to the original version.
Do Bare Rocks Exist on the Moon?
Allen, Carlton; Bandfield, Joshua; Greenhagen, Benjamin; Hayne, Paul; Leader, Frank; Paige, David
2017-01-01
Astronaut surface observations and close-up images at the Apollo and Chang'e 1 landing sites confirm that at least some lunar rocks have no discernable dust cover. However, ALSEP (Apollo Lunar Surface Experiments Package) measurements as well as astronaut and LADEE (Lunar Atmosphere and Dust Environment Explorer) orbital observations and laboratory experiments possibly suggest that a fine fraction of dust is levitated and moves across and above the lunar surface. Over millions of years such dust might be expected to coat all exposed rock surfaces. This study uses thermal modeling, combined with Diviner (a Lunar Reconnaissance Orbiter experiment) orbital lunar eclipse temperature data, to further document the existence of bare rocks on the lunar surface.
Lost interest for existing compounds: New boosts.
Friedhoff, Lawrence T; Dailey, James
2015-07-01
Development of new drugs is typically thought of as a bottom-up endeavor where basic science identifies a target, various strategies are used to generate drugs that stimulate or inhibit the target, the drugs are first tested for safety and efficacy in animals and finally efficacy and safety are evaluated in a well defined clinical development process. However, this is not the only way that new drug products are developed. Many new products come from re-initiating development of discontinued drugs, finding new uses for existing drugs, creating a new product by obtaining marketing approval in expanded territories, obtaining approvals for new formulations or a single isomer of a previously approved racemic drug, converting products from prescription to over-the- counter use or converting folk medicines or vitamins to modern pharmaceuticals. Based on this long and successful history of contributions to modern therapeutics, these alternative sources of new products should not be neglected.
Normokalemic periodic paralysis revisited: does it exist?
Chinnery, Patrick F; Walls, Timothy J; Hanna, Michael G; Bates, David; Fawcett, Peter R W
2002-08-01
Normokalemic periodic paralysis (normoKPP) is well established in the literature, but there are doubts as to whether it exists as a discrete entity. Retrospective clinical and molecular analysis has confirmed suspicions that most normoKPP families actually have a variant of hyperkalemic periodic paralysis (hyperKPP) due to a mutation of the muscle-specific sodium channel gene (SCN4A). However, the original normoKPP family described by Poskanzer and Kerr (Poskanzer DC, Kerr DNS. A third type of periodic paralysis, with normokalemia and favourable response to sodium chloride. Am J Med 1961;31:328-342) has remained unchallenged. We identified the Met1592Val mutation of SCN4A in an affected descendent of this original normoKPP family. This is the final piece in the puzzle: normoKPP is actually a variant of hyperKPP and is not a distinct disorder.
Compilation of Existing Neutron Screen Technology
N. Chrysanthopoulou
2014-01-01
Full Text Available The presence of fast neutron spectra in new reactors is expected to induce a strong impact on the contained materials, including structural materials, nuclear fuels, neutron reflecting materials, and tritium breeding materials. Therefore, introduction of these reactors into operation will require extensive testing of their components, which must be performed under neutronic conditions representative of those expected to prevail inside the reactor cores when in operation. Due to limited availability of fast reactors, testing of future reactor materials will mostly take place in water cooled material test reactors (MTRs by tailoring the neutron spectrum via neutron screens. The latter rely on the utilization of materials capable of absorbing neutrons at specific energy. A large but fragmented experience is available on that topic. In this work a comprehensive compilation of the existing neutron screen technology is attempted, focusing on neutron screens developed in order to locally enhance the fast over thermal neutron flux ratio in a reactor core.
[The depression epidemic does not exist].
van der Feltz-Cornelis, Christina M
2009-01-01
There has been much discussion in the media about the question of the existence of a depression epidemic. This leads on to the questions of whether the social and economic approaches are adequate, and what the alternatives are. The concept of the disease 'depression' can be defined using a medical model, or from a patient's or a societal perspective. From a medical perspective, indeed a depression epidemic has ensued from the increased prosperity and the associated decompression of the mortality rate. Society responded with preventative measures and policies aimed at improving functioning in the workplace. However, patients with a major depressive disorder (MDD) who are eligible for treatment are often not motivated to take it up, or are undertreated. Research is necessary in order to explore what patients think about the identification and treatment of depression. The confusion regarding the concept of depression found in the media, needs to be cleared.
Sustainability in the existing building stock
Elle, Morten; Nielsen, Susanne Balslev; Hoffmann, Birgitte
2005-01-01
This paper explores the role of Facilities Management in the relation to sustainable development in the existing building stock. Facilities management is a concept still developing as the management of buildings are becoming more and more professional. Many recognize today that facilities...... management is a concept relevant to others than large companies. Managing the flows of energy and other resources is a part of facilities management, and an increased professionalism could lead to the reduction of the use of energy and water and the generation of waste and wastewater. This is, however......, QRWfacilities management’s most important contribution to sustainable development in the built environment. Space management is an essential tool in facilities management – and it could be considered a powerful tool in sustainable development; remembering that the building not being built is perhaps the most...
The existence of a bug chasing subculture.
Moskowitz, David A; Roloff, Michael E
2007-01-01
This study attempted to authenticate the existence of a controversial subculture of gay men, the 'bug chasers', whose main attribute is an active desire to voluntarily contract the human immunodeficiency virus (HIV), and examine the tenacity with which this subculture actually searches for seroconversion. Using a quasi-randomized survey of personal profiles, bug chasers were compared against barebackers, a culture of gay men that practice intentional unprotected anal intercourse. Bug chasers were authenticated as an observable subculture of barebackers where most reported apathy to the serostatus of their partner or an active want of a serodiscordant partner, and a preference towards practicing unprotected anal intercourse. As anticipated, two subgroups with varying tenacities were found within the sample of bug chasers. Apathetic chasers were found only to be in search of partners with sero-ambiguous status. Ardent chasers were found only to be in search of certifiably serodiscordant partners.
On the Existence of Spacetime Structure
Curiel, E
2015-01-01
I examine the debate between substantivalists and relationalists about the ontological character of spacetime and conclude it is not well posed. I argue that the so-called Hole Argument does not bear on the debate, because it provides no clear criterion to distinguish the positions. I propose two such precise criteria and construct separate arguments based on each to yield contrary conclusions, one supportive of something like relationalism and the other of something like substantivalism. The lesson is that one must fix an investigative context in order to make such criteria precise, but different investigative contexts yield inconsistent results. I examine questions of existence about spacetime structures other than the spacetime manifold itself to argue that it is more fruitful to focus on pragmatic issues of physicality, a notion that lends itself to several different explications, all of philosophical interest, none privileged a priori over any of the others. I conclude by suggesting an extension of the l...
Co-existence in multispecies biofilm communities
Røder, Henriette Lyng
each other and in understanding the key mechanisms and interactions involved. In the introduction of this thesis the most important concepts of multi-species interactions and biofilm development are explained. After this the topic changes to the various ways of examining community interactions...... of member species increases. After this, various approaches taken by different studies when investigating multispecies communities are discussed, and different techniques for studying multispecies biofilm are described. In manuscript 2, a diverse group of bacteria was co-isolated from a meat processing...... the community. The increased biofilm biomass produced by the new wrinkled variant of X. retroflexus lead to a more positive or neutral co-existence with P. amylolyticus compared to the wild type X. retroflexus. Manuscript 6 investigated how a multispecies biofilm was affected from grazing by the heterotrophic...
Does filial piety exist under Chinese communism?
Chow, N
1991-01-01
China has been known for centuries for its traditions of respecting the old. While this tradition has been weakened in the modern era, it still remains as the most important value underlying the practice of supporting the old in present-day China. This article looks into the meaning of filial piety, or xiao, and examines how it has been observed both in the old and modern times. It argues that though the Chinese communists have found filial piety ideologically repulsive, they have nevertheless tolerated it and even used it as the basis for a welfare network to support the elderly in the villages. However, in order to be truthful to their socialist ideology, they have also provided for urban workers the most sophisticated state-financed retirement benefits. Two different kinds of systems to support the elderly hence exist in China. The tensions resulting from this dichotomous situation are examined.
Does the Kuleshov Effect Really Exist?
Barratt, Daniel; Rédei, Anna Cabak; Innes-Ker, Åse
2016-01-01
of the target person in terms of valence, arousal, and category. The participants’ eye movements were recorded throughout. The results suggest that some sort of Kuleshov effect does in fact exist. For each emotional condition, the participants tended to choose the appropriate category more frequently than...... to replicate Kuleshov’s original experiment using an improved experimental design. In a behavioral and eye tracking study, 36 participants were each presented with 24 film sequences of neutral faces across six emotional conditions. For each film sequence, the participants were asked to evaluate the emotion...... the alternative options, while the answers to the valence and arousal questions also went in the expected directions. The eye tracking data showed how the participants attended to different regions of the target person’s face (in light of the intermediate context), but did not reveal the expected differences...
The pastor as model for peaceful existence
Terence Cooke
2011-06-01
Full Text Available Many people are disillusioned in the democratic South Africa. That is because they went out from the assumption that with the dawn of democracy, violence would disappear. Unfortunately this did not happen. As with most things in life it is not an either � or, but a both � and scenario. In fact, violence is part of the democratic system. Real peace between men and powers can only be the peace of God, the peace which alone heals all disorder. The peace of the world is at best peaceful coexistence, not peace.In South Africa we have a negotiated agreement to peaceful coexistence, and sometimes, for example, after the miracle of the 1994 election and the euphoria of the World Cups of 1995, 2007 and 2010, we may even think we have achieved real peace. It is indeed in these times of euphoria that the people of South Africa may be tempted to lower our aim and settle for second best thinking that we have arrived.Model is used not in the sense of the pastor being an example of a peaceful existence to be followed. It is rather used in the sense that a pastor in his or her professional capacity has the knowledge of the meaning of the term �peaceful existence� and also the hermeneutic competency to apply that knowledge in concrete situations. This opens the exiting possibility that pastors can become travel companions on the road to real peace.The different aspects of being a pastor, office bearer, professional and person, each contribute to the pastor being a model for peace. It must be emphasised that the different aspects always work together as a unity and the strength of the pastor as a model for a peaceful existence is in the simultaneous application of these aspects in the context in which the pastor lives.
KEEPERS OF INFORMATION OF ITS EXISTENCE REASONS
Y. M. Amirbegov
2015-01-01
Full Text Available The main subject of our research is all that is in our minds its concrete expression as objective forms of being, designated by the concept "matter", and on a range of factors of collation: curvature, polarity, tonality, length, height, width, frequency-order – by concept "form". Our goal - to find out why and how unstablemortal world, where “everything flows and everything changes”, stores information about these forms of being our knowledge of them. Researching the subject of our interest by dialectical method of reasoning, we concluded that the information about the forms of being saved by our knowledge because the elements of the molecular structures of our tissue cells - keepers of information of its existence reasons, as well as our tissue cells interspersed in generations, similar repeating the ontogeny of their predecessors, which preserves the structure of our brain tissue and preserving our knowledge. Following the intended purpose, we find that the principle of formation of matter forms in the causal stages of movement is one, whereas the quantitative and qualitative differences between the forms of becoming being are inexhaustible. Forms and patterns of life are mixed, some of which are centralized by unity (nucleus, others - no. Centralized structure (photon, atom, solar system, human tissue cell, man except complex of collation factors differ from decentralized (non-nuclear structures (stone, metal, clay, etc. that interspersed in generations, reproducing his likeness. About why the centralized by unity keepers of information of its existence reasons generated and generate their likeness, and what saves information about the forms of being of our knowledge, and will be discussed in this article.
Energy consumptions in existing buildings; Les consommations d'energie des batiments existants
Nuss, St. [Ecole Nationale Superieure des Arts et Industries de Strasbourg, 78 - Saint-Remy-Les-Chevreuse (France)]|[Costic, 78 - Sainte Remy les Chevreuses (France)
2002-05-01
This document presents a sectoral analysis of the energy consumptions in existing French buildings: 1) - residential sector: social buildings, private dwellings; 2) - tertiary sector: office buildings, hotels, commercial buildings, school buildings, hospitals; 3) - industry; 4) - general status. (J.S.)
THE EXISTENCE AND THE NON-EXISTENCE OF GLOBAL SOLUTIONS OF A FREE BOUNDARY PROBLEM
Yin Rong; Yu Wanghui
2004-01-01
We study a free boundary problem of parabolic equations with a pos-itive parameter τ included in the coefficient of the derivative with respect to the timevariable t. This problem arises from some reaction-diffusion system. We prove that, ifτ is large enough, the solution exists for 0 ＜ t ＜ +∞; while, if τ is small enough, thesolution exists only in finite time.
Seed source variation and conservation of Pinus wallichiana in India
Manisha Thapliyal; Ombir Singh; Babita Sah; Nawa Bahar
2013-01-01
.... Considerable variation in morphological and anatomical characteristics of needles, cones and seeds in natural stands exists across the natural distribution of the species, especially in mesic and xeric habitats...
Variational Approach to Impulsive Problems: A Survey of Recent Results
Fang-fang Liao
2014-01-01
Full Text Available We present a survey on the existence of nontrivial solutions to impulsive differential equations by using variational methods, including solutions to boundary value problems, periodic solutions, and homoclinic solutions.
Fuzzy Generalized Variational Like Inequality problems in Topological Vector Spaces
M. K. Ahmad
2013-01-01
Full Text Available This paper is devoted to the existence of solutions for generalized variational like inequalities with fuzzy mappings in topological vector spaces by using a particular form of the generalized KKM-Theorem.
ECOLOGICAL CONDITIONS OF EXISTENCE OF MYCOBACTERIA POPULATIONS
R. A. Nuratinov
2014-01-01
Full Text Available Abstract. Aim. Adaptation possibilities of mycobacteria in the conditions of existence in the external environment and habitats of animals and man are studied. Adaptation mechanisms, which have pathogenic mycobacteria, allow them to survive long and circulate in the environment, which leads to special sanitary and epidemiological value of pathogens of tuberculosis. Location. Russia, Dagestan.Results. Mycobacterium tuberculosis has a high resistance to influence of cold, heat, chemical and physical factors, moisture and light. They carry high and low temperatures, while more than a year pathogenic properties, and even more in the dark and without sunlight. It should be noted that the stability of pathogenic species of mycobacteria in the external environment is relatively lower than that of saprophytes, capable of quickly adapting to the external environment. Raonin’s groups have more widespread in environment, in water, soil, air, plants, and habitats of animals, products of plant and animal origin and their often isolated from clinical samples.Main conclusions. Environmental conditions define the intensity of habitats of any species of mycobacteria in certain landscapes and their circulation in macroorganism. The impact of the various elements of the environment both in the macro- and microorganisms is a response that was the basis for the development of the doctrine about “limiting factors”. This concept applies not only to the necessary for mycobacteria chemical elements, but also to all the other environmental factors (temperature, humidity, aeration conditions etc. Minimum and maximum intensity factors determine the limits of endurance species. Beyond these limits, due to sharply expressed extreme conditions and is portable microorganism existence of species is not possible. The most favorable for the species optimum intensity of environmental factors, usually occupied a middle position. This provision is significantly
Ladder Variational Autoencoder
Sønderby, Casper Kaae; Raiko, Tapani; Maaløe, Lars
2016-01-01
Variational autoencoders are powerful models for unsupervised learning. However deep models with several layers of dependent stochastic variables are difficult to train which limits the improvements obtained using these highly expressive models. We propose a new inference model, the Ladder Variat...
Genetic variation in variability
Mulder, Herman; Gienapp, Phillip; Visser, Marcel E.
2016-01-01
Variation in traits is essential for natural selection to operate and genetic and environmental effects can contribute to this phenotypic variation. From domesticated populations, we know that families can differ in their level of within-family variance, which leads to the intriguing situation th
Alves, Claudianor O.; Miyagaki, Olímpio H.
2017-08-01
In this paper, we establish some results concerning the existence, regularity, and concentration phenomenon of nontrivial solitary waves for a class of generalized variable coefficient Kadomtsev-Petviashvili equation. Variational methods are used to get an existence result, as well as, to study the concentration phenomenon, while the regularity is more delicate because we are leading with functions in an anisotropic Sobolev space.
An evolutionary ecologist's view of how to study the persistence of genetic variation in personality
Dingemanse, Niels J.
2007-01-01
Personality is commonly regarded to involve either 'correlations among behavioural traits' or 'consistent individual differences in behaviour across contexts'. Any evolutionary explanation for the existence of genetic variation in personality must therefore not only address why genetic variation in
ProtoEXIST: advanced prototype CZT coded aperture telescopes for EXIST
Allen, Branden; Hong, Jaesub; Grindlay, Josh; Barthelmy, Scott D.; Baker, Robert G.; Gehrels, Neil A.; Garson, Trey; Krawczynski, Henric S.; Cook, Walter R.; Harrison, Fiona A.; Apple, Jeffrey A.; Ramsey, Brian D.
2010-07-01
ProtoEXIST1 is a pathfinder for the EXIST-HET, a coded aperture hard X-ray telescope with a 4.5 m2 CZT detector plane a 90x70 degree field of view to be flown as the primary instrument on the EXIST mission and is intended to monitor the full sky every 3 h in an effort to locate GRBs and other high energy transients. ProtoEXIST1 consists of a 256 cm2 tiled CZT detector plane containing 4096 pixels composed of an 8x8 array of individual 1.95 cm x 1.95 cm x 0.5 cm CZT detector modules each with a 8 x 8 pixilated anode configured as a coded aperture telescope with a fully coded 10° x 10° field of view employing passive side shielding and an active CsI anti-coincidence rear shield, recently completed its maiden flight out of Ft. Sumner, NM on the 9th of October 2009. During the duration of its 6 hour flight on-board calibration of the detector plane was carried out utilizing a single tagged 198.8 nCi Am-241 source along with the simultaneous measurement of the background spectrum and an observation of Cygnus X-1. Here we recount the events of the flight and report on the detector performance in a near space environment. We also briefly discuss ProtoEXIST2: the next stage of detector development which employs the NuSTAR ASIC enabling finer (32×32) anode pixilation. When completed ProtoEXIST2 will consist of a 256 cm2 tiled array and be flown simultaneously with the ProtoEXIST1 telescope.
Total variation regularization with bounded linear variations
Makovetskii, Artyom; Voronin, Sergei; Kober, Vitaly
2016-09-01
One of the most known techniques for signal denoising is based on total variation regularization (TV regularization). A better understanding of TV regularization is necessary to provide a stronger mathematical justification for using TV minimization in signal processing. In this work, we deal with an intermediate case between one- and two-dimensional cases; that is, a discrete function to be processed is two-dimensional radially symmetric piecewise constant. For this case, the exact solution to the problem can be obtained as follows: first, calculate the average values over rings of the noisy function; second, calculate the shift values and their directions using closed formulae depending on a regularization parameter and structure of rings. Despite the TV regularization is effective for noise removal; it often destroys fine details and thin structures of images. In order to overcome this drawback, we use the TV regularization for signal denoising subject to linear signal variations are bounded.
Does occupational health nursing exist in India?
Rajnarayan R Tiwari
2014-01-01
Full Text Available Background: Occupational health services are important to develop healthy and productive work forces, which should be delivered through occupational health team. Occupational health nurse (OHN is an important member of this team and is required to apply nursing principles in conserving the health of workers in occupational settings. Purpose: This article attempts to map the occupational health nursing courses in India and design competencies and curriculum for such a course. Materials and Methods: Information through the Internet, printed journals, and perspectives of the key stakeholders were the principal sources of data. Discussion: In India, there is a need to initiate a course on occupational health nursing to provide occupational health services for the organized and unorganized sector workforce. A certificate course for occupational health nursing for 3-4 months duration offered through contact session mode can be an opportune beginning. However, to cater employed nurses an online course can be another effective alternative. The theoretical part should essentially include modules on occupational diseases, industrial hygiene, and occupational health legislation, whereas the modules on practical aspects can include visits to industries. Taking into account the existing norms of Indian Factories Act for hazardous units of organized sector an estimated 1,34,640 OHNs are required. Conclusion: There is a need-supply gap in the number of occupational health nursing manpower in India, which can be attributed to the absence of any course to train such manpower.
Existence dimension of media-educational space
B. V. Bratanich
2014-03-01
Full Text Available The world media culture is the everyday existential context of selfidentity. Entry into the media culture turns and practice, and by the adequate development of the problem field of human existence. Education as a way to selfdetermine human ways and purposes of entry into the modern media culture in the field of communication and interaction with other people, mediated by electronic media. In the presence of global media space fundamental information plays a crucial role in socialization, is formed at the intersection of the education system and the electronic media, which gives grounds to determine exactly mediaeducational community primary medium of socialization in the age of online media. Media education environment creates more favorable conditions to educational activities has become a way of selfidentity, as it results of creative activity of the subject taken by others as taking it himself, his personality. Its major advantage as space being is to provide the maximum activity of the individual in determining the trajectory of development. A common basis for resolving the risks socialization and being the person in the media education area are the values and goals of selfdevelopment, formulated within postmodern education.
Seismic evaluation methods for existing buildings
Hsieh, B.J.
1995-07-01
Recent US Department of Energy natural phenomena hazards mitigation directives require the earthquake reassessment of existing hazardous facilities and general use structures. This applies also to structures located in accordance with the Uniform Building Code in Seismic Zone 0 where usually no consideration is given to seismic design, but where DOE specifies seismic hazard levels. An economical approach for performing such a seismic evaluation, which relies heavily on the use of preexistent structural analysis results is outlined below. Specifically, three different methods are used to estimate the seismic capacity of a building, which is a unit of a building complex located on a site considered low risk to earthquakes. For structures originally not seismically designed, which may not have or be able to prove sufficient capacity to meet new arbitrarily high seismic design requirement and which are located on low-seismicity sites, it may be very cost effective to perform detailed site-specific seismic hazard studies in order to establish the true seismic threat. This is particularly beneficial, to sites with many buildings and facilities to be seismically evaluated.
Do cement nanoparticles exist in space ?
Bilalbegovic, G; Mohacek-Grosev, V
2014-01-01
The calcium-silicate-hydrate is used to model properties of cement on Earth. We study cementitious nanoparticles and propose these structures as components of cosmic dust grains. Quantum density functional theory methods are applied for the calculation of infrared spectra of Ca4Si4O14H4, Ca6Si3O13H2, and Ca12Si6O26H4 clusters. We find bands distributed over the near, mid and far-infrared region. A specific calcium-silicate-hydrate spectral feature at 14 microns, together with the bands at 10 and 18 microns which exist for other silicates as well, could be used for a detection of cosmic cement. We compare calculated bands with the 14 microns features in the spectra of HD 45677, HD 44179, and IRC+10420 which were observed by Infrared Space Observatory and classified as remaining. High abundance of oxygen atoms in cementitious nanoparticles could partially explain observed depletion of this element from the interstellar medium into dust grains.
Expert system interaction with existing analysis codes
Ransom, V.H.; Fink, R.K.; Bertch, W.J.; Callow, R.A.
1986-01-01
Coupling expert systems with existing engineering analysis codes is a promising area in the field of artificial intelligence. The added intelligence can provide for easier and less costly use of the code and also reduce the potential for code misuse. This paper will discuss the methods available to allow interaction between an expert system and a large analysis code running on a mainframe. Concluding remarks will identify potential areas of expert system application with specific areas that are being considered in a current research program. The difficulty of interaction between an analysis code and an expert system is due to the incompatibility between the FORTRAN environment used for the analysis code and the AI environment used for the expert system. Three methods, excluding file transfer techniques, are discussed to help overcome this incompatibility. The first method is linking the FORTRAN routines to the LISP environment on the same computer. Various LISP dialects available on mainframes and their interlanguage communication capabilities are discussed. The second method involves network interaction between a LISP machine and a mainframe computer. Comparisons between the linking method and networking are noted. The third method involves the use of an expert system tool that is campatible with a FORTRAN environment. Several available tools are discussed. With the interaction methods identified, several potential application areas are considered. Selection of the specific areas that will be developed for the pilot project and applied to a thermal-hydraulic energy analysis code are noted.
Modernization of existing VVER-1000 surveillance programs
Kochkin, V.; Erak, D.; Makhotin, D. [NRC ' Kurchatov Inst.' , 1 Kurchatov Square, Moscow 123182 (Russian Federation)
2011-07-01
According to generally accepted world practice, evaluation of the reactor pressure vessel (RPV) material behavior during operation is carried out using tests of surveillance specimens. The main objective of the surveillance program consists in insurance of safe RPV operation during the design lifetime and lifetime-extension period. At present, the approaches of pressure vessels residual life validation based on the test results of their surveillance specimens have been developed and introduced in Russia and are under consideration in other countries where vodo-vodyanoi energetichesky reactors- (VVER-) 1000 are in operation. In this case, it is necessary to ensure leading irradiation of surveillance specimens (as compared to the pressure vessel wall) and to provide uniformly irradiated specimen groups for mechanical testing. Standard surveillance program of VVER-1000 has several significant shortcomings and does not meet these requirements. Taking into account program of lifetime extension of VVER-1000 operating in Russia, it is necessary to carry out upgrading of the VVER-1000 surveillance program. This paper studies the conditions of a surveillance specimen's irradiation and upgrading of existing sets to provide monitoring and prognosis of RPV material properties for extension of the reactor's lifetime up to 60 years or more. (authors)
Moses, Julianne I.; Nash, Douglas B.
1991-01-01
Laboratory investigations have been conducted on the effects of variations in sulfur sample histories on their solid-state transformation rate and the corresponding spectral variation of freshly frozen sulfur. The temporal variations in question may be due to differences in the amount and type of metastable allotropes present in the sulfur after solidification, as well as to the physics of the phase-transformation process itself. The results obtained are pertinent to the physical behavior and spectral variation of such freshly solidified sulfur as may exist on the Jupiter moon Io; this would initially solidify into a glassy solid or monoclinic crystalline lattice, then approach ambient dayside temperatures. Laboratory results imply that the monoclinic or polymeric allotropes can in these circumstances be maintained, and will take years to convert to the stable orthorhombic crystalline form.
Sara Sheikholeslami
2014-02-01
Full Text Available Medullary thyroid carcinoma (MTC occurs in both sporadic (75% and hereditary (25% forms. The missense mutations of the REarranged during Transfection (RET proto-oncogene in MTC development have been well demonstrated. The aim of this study was to investigate frequency of G691S/S904S haplotype in MTC patients and their relatives.In this research 293 participants were studied, including 181 patients (102 female, 79 male and 112 their relatives (58 female, 54 male. Genomic DNA was extracted from peripheral blood leucocytes using the standard Salting Out/Proteinase K method. Nucleotide change detection was performed using PCR and direct DNA sequencing methods.According to DNA sequencing results, 159 individuals (104 patients, 55 relatives had both G691S (rs1799939 missense mutation in exon11 and S904S (rs1800863 synonymous mutation in exon 15 of RET proto-oncogene. The allele frequency of G691S/S904S haplotype was 21.15% in patients and 10.75% in their relatives.The obtained data showed the frequency of G691S/S904S RET gene haplotype among Iranian MTC patients and their relatives. The G691S and S904S nucleotide changes were in complete linkage disequilibrium, so the results were grouped together and referred to as G691S/S904S haplotype. Further analysis is need to demonstrate the association between this haplotype and MTC development.
Schierup, M.H.; Mailund, T.; Li, H.
2009-01-01
Background: A small region of about 70 kb on human chromosome 19q13.3 encompasses 4 genes of which 3, ERCC1, ERCC2, and PPP1R13L (aka RAI) are related to DNA repair and cell survival, and one, CD3EAP, aka ASE1, may be related to cell proliferation. The whole region seems related to the cellular r...
Schierup, M.H.; Mailund, T.; Li, H.
2009-01-01
Background: A small region of about 70 kb on human chromosome 19q13.3 encompasses 4 genes of which 3, ERCC1, ERCC2, and PPP1R13L (aka RAI) are related to DNA repair and cell survival, and one, CD3EAP, aka ASE1, may be related to cell proliferation. The whole region seems related to the cellular r...
Zivanovic, D; Bojic, S; Medenica, L; Andric, Z; Popadic, D
2016-05-01
The etiology of pemphigus vulgaris (PV) is multifactorial and includes genetic, environmental, hormonal, and immunological factors. Inheritance of certain Human class II leukocyte antigen (HLA) alleles is by far the best-established predisposing factor for the development of PV. Class II HLA alleles vary among racial/ethnic backgrounds. We have determined an association between HLA class II alleles and PV among the Serbian population. A total of 72 patients with confirmed diagnosis of PV were genotyped for HLA class II alleles. HLA frequencies were compared with unrelated healthy bone marrow donors. The statistical significance of differences between patients and controls was evaluated using Fisher's exact test. The DRB1*04 and DRB1*14 allelic groups were associated with PV (P adj = 4.45 × 10(-13) and 4.06 × 10(-19) respectively), while HLA-DRB1*11 was negatively associated with PV (P adj = 0.0067) suggesting a protective role. DRB1*04:02, DRB1*14:04, DQB1*03:02 and DQB1*05:03 alleles were shown to be strongly associated with PV (P adj = 1.63 × 10(-12), 5.20 × 10(-7), 1.28 × 10(-6), and 4.44 × 10(-5), respectively). The frequency of HLA DRB1*04-DQB1*03 and HLA DRB1*14-DQB1*05 haplotypes in PV patients was significantly higher than in controls (31.3% vs 8.8%, P adj =7.66 × 10(-8) and 30.6% vs 6.3%, P adj = 3.22 × 10(-10), respectively). At high-resolution level, statistical significance was observed in HLA-DRB1*04:02-DQB1*03:02 and HLA-DRB1*14:04-DQB1*05:03 haplotypes (P adj = 5.55 × 10(-12), and P adj = 3.91 × 10(-6), respectively). Our findings suggest that HLA-DRB1*04:02, DRB1*14:04, HLA-DQB1* 03:02 and DQB1*05:03 alleles and HLA-DRB1*04:02-DQB1*03:02 and HLA-DRB1*14:04-DQB1*05:03 haplotypes are genetic markers for susceptibility for PV, while DRB1*11 allelic group appears protective in Serbian population.
Ellis, Lisa L.; Huang, Wen; Quinn, Andrew M.; Ahuja, Astha; Alfrejd, Ben; Gomez, Francisco E.; Hjelmen, Carl E.; Moore, Kristi L.; Mackay, Trudy F. C.; Johnston, J. Spencer; Tarone, Aaron M.
2014-01-01
We determined female genome sizes using flow cytometry for 211 Drosophila melanogaster sequenced inbred strains from the Drosophila Genetic Reference Panel, and found significant conspecific and intrapopulation variation in genome size. We also compared several life history traits for 25 lines with large and 25 lines with small genomes in three thermal environments, and found that genome size as well as genome size by temperature interactions significantly correlated with survival to pupation and adulthood, time to pupation, female pupal mass, and female eclosion rates. Genome size accounted for up to 23% of the variation in developmental phenotypes, but the contribution of genome size to variation in life history traits was plastic and varied according to the thermal environment. Expression data implicate differences in metabolism that correspond to genome size variation. These results indicate that significant genome size variation exists within D. melanogaster and this variation may impact the evolutionary ecology of the species. Genome size variation accounts for a significant portion of life history variation in an environmentally dependent manner, suggesting that potential fitness effects associated with genome size variation also depend on environmental conditions. PMID:25057905
Lisa L Ellis
2014-07-01
Full Text Available We determined female genome sizes using flow cytometry for 211 Drosophila melanogaster sequenced inbred strains from the Drosophila Genetic Reference Panel, and found significant conspecific and intrapopulation variation in genome size. We also compared several life history traits for 25 lines with large and 25 lines with small genomes in three thermal environments, and found that genome size as well as genome size by temperature interactions significantly correlated with survival to pupation and adulthood, time to pupation, female pupal mass, and female eclosion rates. Genome size accounted for up to 23% of the variation in developmental phenotypes, but the contribution of genome size to variation in life history traits was plastic and varied according to the thermal environment. Expression data implicate differences in metabolism that correspond to genome size variation. These results indicate that significant genome size variation exists within D. melanogaster and this variation may impact the evolutionary ecology of the species. Genome size variation accounts for a significant portion of life history variation in an environmentally dependent manner, suggesting that potential fitness effects associated with genome size variation also depend on environmental conditions.
Sharing information among existing data sources
Ashley, W. R., III
1999-01-01
The sharing of information between law enforcement agencies is a premise for the success of all jurisdictions. A wealth of information resides in both the databases and infrastructures of local, state, and regional agencies. However, this information is often not available to the law enforcement professionals who require it. When the information is, available, individual investigators must not only know that it exists, but where it resides, and how to retrieve it. In many cases, these types of cross-jurisdictional communications are limited to personal relationships that result from telephone calls, faxes, and in some cases, e-mail. As criminal elements become more sophisticated and distributed, law enforcement agencies must begin to develop infrastructures and common sharing mechanisms that address a constantly evolving criminal threat. Historically, criminals have taken advantage of the lack of communication between law enforcement agencies. Examples of this are evident in the search for stolen property and monetary dealings. Pawned property, cash transactions, and failure to supply child support are three common cross- jurisdictional crimes that could be better enforced by strengthening the lines of communication. Criminal behavior demonstrates that it is easier to profit from their actions by dealing in separate jurisdictions. For example, stolen property is sold outside of the jurisdiction of its origin. In most cases, simply traveling a short distance to the adjoining county or municipality is sufficient to ensure that apprehension of the criminal or seizure of the stolen property is highly unlikely. In addition to the traditional burglar, fugitives often sell or pawn property to finance their continued evasion from the law. Sharing of information in a rapid manner would increase the ability of law enforcement personnel to track and capture fugitives, as well as criminals. In an example to combat this threat, the State of Florida recently acted on the need to
Why does allergic contact dermatitis exist?
McFadden, J P; Puangpet, P; Basketter, D A; Dearman, R J; Kimber, I
2013-04-01
The skin immune system's propensity to produce allergic contact dermatitis (ACD) to harmless chemicals, while otherwise being an efficient defence system, represents a dermatological paradox. We postulate that a major role in signalling in ACD is played by Toll-like receptor (TLR)2 and TLR4, and arises from their activation by extracellular danger-associated molecular patterns (DAMPs). Ligand activation of TLR4/2 results in the expression of interleukins (ILs) IL-1β, IL-6, IL-12, IL-18 and IL-23, tumour necrosis factor-α and interferon-α. These cytokines promote acquisition of sensitization, and facilitate elicitation of contact allergy via multiple mechanisms, including the recruitment of CD4+ Th1 and Th17 cells. As Th1 cells secrete large amounts of DAMPs, a DAMP immune circuit (positive-feedback loop) is created. This is an important driver of skin sensitization and skin inflammation. Pathogenic extracellular bacteria, but not commensal bacteria, produce pathogen-associated molecular pattern molecules, which stimulate the expression of Th1- and Th17-promoting cytokines via TLR2 and TLR4. This also induces an immune circuit. The ability of the skin immune system to activate host defence mechanisms and to distinguish between pathogenic bacteria and commensals provides an explanation for why skin sensitization and ACD develop, as they are processes that rely on the same biological pathways. These pathways may also shed light on the pathogenesis of chronic pustular inflammatory dermatoses (e.g. acne vulgaris). The existence of safety signals from commensal bacteria, which prevent initiation of these pathways, may provide opportunities for novel therapeutic approaches to the treatment of inflammatory skin diseases.
David Barker: the revolution that anticipates existence
Italo Farnetani
2014-01-01
Full Text Available David Barker is the man who “anticipated" the existence of babies by focusing attention on the importance of the fetus and what takes place during intrauterine life. Barker was one of the physicians who in the last decades brought about the greatest changes in medicine, changes so important as to represent a veritable revolution in medical thought. According to Barker's studies, the embryo obviously has a genetic complement coming from the mother and father, but from the very first stages of development it begins to undergo the influence of the outside environment, just as occurs for adults whose biological, psychological and pathological aspects are influenced by the environment to a not well-established percentage between genetic complement and epigenetics. Much of our future lives as adults is decided in our mothers' wombs. If Barker's discovery was revolutionary from the cultural standpoint, it was even more so from the strictly medical one. Barker's research method was rigid from the methodological standpoint, but innovative and speculative in its working hypotheses, with a humanistic slant. Barker's idea has another practical corollary: it is evident that the role of obstetricians, perinatologists and neonatologists is more and more relevant in medicine and future prevention. Unquestionably, besides the enormous merits of his clinical research, among the benefits that Barker has contributed there is that of having helped us to see things from new points of view. Not only is the neonate (and even more so the fetus not an adult of reduced proportions, but perhaps the neonate is the "father" of the adult person.
Illness as a condition of our existence in the world: on illness and pathic existence.
Martinsen, Elin Håkonsen; Solbakk, Jan Helge
2012-06-01
This paper seeks to find different ways of addressing illness as an experience essential to the understanding of being a human being. As a conceptual point of departure, we suggest the notion of 'pathic existence' as developed by the German physician and philosopher Viktor von Weizsäcker (1886-1957). Through an analysis of his conceptualisation of the pathic and of pathic categories, we demonstrate how this auxiliary typology may be of help in unveiling different modes of ill-being, or Kranksein. Furthermore, we show how illness plays a paradigmatic role in this type of existence. We discuss how von Weizsäcker's claim of illness as "a way of being human" indicates how such a view of the illness existence both differs from and touches upon other streams of thought within the philosophy of medicine and medical ethics. Finally, we highlight some of the normative implications emerging from this perspective of relevance in today's medicine.
MtDNA T4216C variation in multiple sclerosis
Andalib, Sasan; Emamhadi, Mohammadreza; Yousefzadeh-Chabok, Shahrokh
2016-01-01
MtDNA T4216C variation has frequently been investigated in Multiple Sclerosis (MS) patients; nonetheless, controversy has existed about the evidence of association of this variation with susceptibility to MS. The present systematic review and meta-analysis converge the results of the preceding...
A variational approach to homogeneous scalar fields in General Relativity
Giambo', R; Magli, G
2006-01-01
A result of existence of homogeneous scalar field solutions between prescribed configurations is given, using a modified version of Euler--Maupertuis least action variational principle. Solutions are obtained as limit of approximating variational problems, solved using techniques introduced by Rabinowitz.
The variation of the electromagnetic coupling and quintessence
Bento, M C
2008-01-01
The properties of quintessence are examined through the study of the variation of the electromagnetic coupling. We consider two simple quintessence models with a modified exponential potential and study the parameter space constraints derived from the existing observational bounds on the variation of the fine structure constant and the most recent Wilkinson Microwave Anisotropy Probe observations.
Practice guidelines, did they reduce medical practice variation?
Jong, J.D. de; Westert, G.P.; Schellevis, F.
2003-01-01
Background: A persistent finding in health services research is that medical practice varies widely between small areas. When clinical variables and patient characteristics are taken into account, residual variation still remains. The existence of this variation is often interpreted as a sign of ove
Inverse Coefficient Problems for Nonlinear Elliptic Variational Inequalities
Run-sheng Yang; Yun-hua Ou
2011-01-01
This paper is devoted to a class of inverse coefficient problems for nonlinear elliptic variational inequalities. The unknown coefficient of elliptic variational inequalities depends on the gradient of the solution and belongs to a set of admissible coefficients. It is shown that the nonlinear elliptic variational inequalities is unique solvable for the given class of coefficients. The existence of quasisolutions of the inverse problems is obtained.
GENERALIZED VECTOR VARIATIONAL-TYPE INEQUALITIES IN FC-SPACES
FANG Min; DING Xie-ping
2006-01-01
A class of generalized vector variational-type inequality problems (GVVTIP) are studied in FC-spaces, which includes the most of vector equilibrium problems, vector variational inequality problems, generalized vector equilibrium problems and generalized vector variational inequality problem as special cases. By using F-KKM theorem,some new existence results for GVVTIP are established in noncompact FC-space. As consequences, some recent known results in literature are obtained under much weaker assumption.
Marin-Garcia Pablo
2010-05-01
Full Text Available Abstract Background The maturing field of genomics is rapidly increasing the number of sequenced genomes and producing more information from those previously sequenced. Much of this additional information is variation data derived from sampling multiple individuals of a given species with the goal of discovering new variants and characterising the population frequencies of the variants that are already known. These data have immense value for many studies, including those designed to understand evolution and connect genotype to phenotype. Maximising the utility of the data requires that it be stored in an accessible manner that facilitates the integration of variation data with other genome resources such as gene annotation and comparative genomics. Description The Ensembl project provides comprehensive and integrated variation resources for a wide variety of chordate genomes. This paper provides a detailed description of the sources of data and the methods for creating the Ensembl variation databases. It also explores the utility of the information by explaining the range of query options available, from using interactive web displays, to online data mining tools and connecting directly to the data servers programmatically. It gives a good overview of the variation resources and future plans for expanding the variation data within Ensembl. Conclusions Variation data is an important key to understanding the functional and phenotypic differences between individuals. The development of new sequencing and genotyping technologies is greatly increasing the amount of variation data known for almost all genomes. The Ensembl variation resources are integrated into the Ensembl genome browser and provide a comprehensive way to access this data in the context of a widely used genome bioinformatics system. All Ensembl data is freely available at http://www.ensembl.org and from the public MySQL database server at ensembldb.ensembl.org.
International symposium on seismic evaluation of existing nuclear facilities
Orbovic, N.; Bouchon, M. [Institut de Radioprotection et de Surete Nucleaire, IRSN, 92 - Fontenay aux Roses (France); Vendel, J.; Gelain, T. [IRSN/DPEA/SERAC, 91 - Gif sur Yvette (France)
2003-10-01
revealed a strong influence of the slab plates and a torsion in the structure. Also, masonry in-fills can significantly alter the seismic behavior of the building. The building is being subjected to a very large retrofit program submitted for approval to IRSN and the Nuclear Safety Authority. The acceptance criteria used to define deficiencies and to retrofit the building were design criteria. Evaluation of existing nuclear facility structures must be conducted with the appropriate level of conservatism. Therefore, even though modern performance-based evaluation procedures for conventional structures are available, they must be rigorously examined before they are used to evaluate nuclear facility structures. This paper presents selected results of an evaluation of various nonlinear static and dynamic demand analysis and FEMA-356 capacity measures on a test-bed nuclear facility reinforced concrete frame structure built in 1960's. It is shown that these modern procedures can be used. Furthermore, they revealed deficiencies of the test-bed structure that could not be easily found using the conventional linear-and-elastic evaluation methods. Nevertheless, more work is needed to calibrate these new procedures for the risk reduction levels required for nuclear facilities before they can be used in nuclear facility design and evaluation practice. The test program consisted of mechanical testy performed on reinforced concrete walls subjected to alternating shear loads. The aim of the program was to define crack geometry (length, width, and spacing). Tests were carried out on 3 low-rise reinforced concrete walls with varying percentages of rebars. Each wall was subjected to a sequence of three increasing loads. One of the three walls was loaded to failure. The main results of the program were measurements of displacement as a function of horizontal force (displacements, variations in diagonal lengths), cracking states during the loading cycle, and deformation of rebars. The
Variational Transition State Theory
Truhlar, Donald G. [Univ. of Minnesota, Minneapolis, MN (United States)
2016-09-29
This is the final report on a project involving the development and applications of variational transition state theory. This project involved the development of variational transition state theory for gas-phase reactions, including optimized multidimensional tunneling contributions and the application of this theory to gas-phase reactions with a special emphasis on developing reaction rate theory in directions that are important for applications to combustion. The development of variational transition state theory with optimized multidimensional tunneling as a useful computational tool for combustion kinetics involved eight objectives.
Lind, Ida; Grøn, Peter
1996-01-01
Vertical porosity variations in chalk are generally assumed to result from either a vaguely defined combination of primary sedimentary and diagenetic processes or solely to diagenetic processes. In this study, image analysis of backscatter electron images of polished samples and geochemical...... microprobe mapping were applied to measure the porosity variation in a limited number of chalk samples. Microscope data indicate that in all cases the chalk has been subjected to diagenetic processes, but our data suggest that the variations in porosity originate in primary sedimentary differences....
A precariedade humana e a existência estilizada Human precariousness and stylized existence
Rita Paiva
2013-04-01
Full Text Available Este artigo tematiza o desamparo vivenciado pela consciência ante a ausência de bases sólidas para seus anseios de felicidade e para suas representações simbólicas. Com esse propósito, toma como objeto de reflexão um dos ensaios filosóficos de Albert Camus, O mito de Sísifo, equacionando a possibilidade de uma ética que estilize a vida, sem que se minimize a dolorosa precariedade da existência humana. Posteriormente, em diálogo com alguns textos de M. Foucault, a reflexão procura estabelecer os vínculos possíveis entre a ética camusiana e a ética como uma estética da existência, tal como pensada entre os gregos antigos.This article discusses the helplessness experienced by the consciousness vis-à-vis the absence of solid bases for its longings for happiness and for its symbolic representations. For this purpose, the object of reflection of the article is one of Albert Camus' philosophical essays, The Myth of Sisyphus, and we inquire into the possibility of an ethics that stylizes life without minimizing the painful precariousness of human existence. Making reference to certain texts by Foucault, we attempt to establish possible connections between Camus' ethics and an ethics of the aesthetics of existence as found in the thinkers of ancient Greece.
ProtoEXIST: Advanced Prototype CZT Coded Aperture Telescopes for EXIST
Allen, Branden; Grindlay, Josh; Barthelmy, Scott D; Baker, Robert G; Gehrels, Neil A; Garson, Trey; Krawwczynski, Henric S; Cook, Walter R; Harrison, Fiona A; Apple, Jeffery A; Ramsey, Brian D; 10.1117/12.857940
2010-01-01
{\\it ProtoEXIST1} is a pathfinder for the {\\it EXIST-HET}, a coded aperture hard X-ray telescope with a 4.5 m$^2$ CZT detector plane a 90$\\times$70 degree field of view to be flown as the primary instrument on the {\\it EXIST} mission and is intended to monitor the full sky every 3 h in an effort to locate GRBs and other high energy transients. {\\it ProtoEXIST1} consists of a 256 cm$^2$ tiled CZT detector plane containing 4096 pixels composed of an 8$\\times$8 array of individual 1.95 cm $\\times$ 1.95 cm $\\times$ 0.5 cm CZT detector modules each with a 8 $\\times$ 8 pixilated anode configured as a coded aperture telescope with a fully coded $10^\\circ\\times10^\\circ$ field of view employing passive side shielding and an active CsI anti-coincidence rear shield, recently completed its maiden flight out of Ft. Sumner, NM on the 9th of October 2009. During the duration of its 6 hour flight on-board calibration of the detector plane was carried out utilizing a single tagged 198.8 nCi Am-241 source along with the simult...
On the total variation dictionary model.
Zeng, Tieyong; Ng, Michael K
2010-03-01
The goal of this paper is to provide a theoretical study of a total variation (TV) dictionary model. Based on the properties of convex analysis and bounded variation functions, the existence of solutions of the TV dictionary model is proved. We then show that the dual form of the model can be given by the minimization of the sum of the l(1) -norm of the dual solution and the Bregman distance between the curvature of the primal solution and the subdifferential of TV norm of the dual solution. This theoretical result suggests that the dictionary must represent sparsely the curvatures of solution image in order to obtain a better denoising performance.
Saturn chorus latitudinal variations
Menietti, J. D; Hospodarsky, G. B; Shprits, Y. Y; Gurnett, D. A
2014-01-01
The variation of propagation properties of whistler mode chorus as a function of latitude is not well known at Saturn but is important for the calculation of pitch angle diffusion and nonlinear growth of chorus...
Das-Smaal, E.A.; Swart, de J.H.
1984-01-01
Two aspects of variation within categories, relating to different models of categorization, were investigated - frequency of dimensional values and typicality differences within values. The influence of range of typicality experienced during learning and of informational value of feedback was also
Variational principles in physics
Basdevant, Jean-Louis
2007-01-01
Optimization under constraints is an essential part of everyday life. Indeed, we routinely solve problems by striking a balance between contradictory interests, individual desires and material contingencies. This notion of equilibrium was dear to thinkers of the enlightenment, as illustrated by Montesquieu’s famous formulation: "In all magistracies, the greatness of the power must be compensated by the brevity of the duration." Astonishingly, natural laws are guided by a similar principle. Variational principles have proven to be surprisingly fertile. For example, Fermat used variational methods to demonstrate that light follows the fastest route from one point to another, an idea which came to be known as Fermat’s principle, a cornerstone of geometrical optics. Variational Principles in Physics explains variational principles and charts their use throughout modern physics. The heart of the book is devoted to the analytical mechanics of Lagrange and Hamilton, the basic tools of any physicist. Prof. Basdev...
The Schwinger Variational Method
Huo, Winifred M.
1995-01-01
Variational methods have proven invaluable in theoretical physics and chemistry, both for bound state problems and for the study of collision phenomena. For collisional problems they can be grouped into two types: those based on the Schroedinger equation and those based on the Lippmann-Schwinger equation. The application of the Schwinger variational (SV) method to e-molecule collisions and photoionization has been reviewed previously. The present chapter discusses the implementation of the SV method as applied to e-molecule collisions.
Generalized quasi variational inequalities
Noor, M.A. [King Saud Univ., Riyadh (Saudi Arabia)
1996-12-31
In this paper, we establish the equivalence between the generalized quasi variational inequalities and the generalized implicit Wiener-Hopf equations using essentially the projection technique. This equivalence is used to suggest and analyze a number of new iterative algorithms for solving generalized quasi variational inequalities and the related complementarity problems. The convergence criteria is also considered. The results proved in this paper represent a significant improvement and refinement of the previously known results.
Ding Rui; Jiang Meiqun; Peng Daping
2005-01-01
The boundary element approximation of the parabolic variational inequalities of the second kind is discussed. First, the parabolic variational inequalities of the second kind can be reduced to an elliptic variational inequality by using semidiscretization and implicit method in time; then the existence and uniqueness for the solution of nonlinear non-differentiable mixed variational inequality is discussed. Its corresponding mixed boundary variational inequality and the existence and uniqueness of its solution are yielded. This provides the theoretical basis for using boundary element method to solve the mixed variational inequality.
Variational approach and deformed derivatives
Weberszpil, J.; Helayël-Neto, J. A.
2016-05-01
Recently, we have demonstrated that there exists a possible relationship between q-deformed algebras in two different contexts of Statistical Mechanics, namely, the Tsallis' framework and the Kaniadakis' scenario, with a local form of fractional-derivative operators for fractal media, the so-called Hausdorff derivatives, mapped into a continuous medium with a fractal measure. Here, in this paper, we present an extension of the traditional calculus of variations for systems containing deformed-derivatives embedded into the Lagrangian and the Lagrangian densities for classical and field systems. The results extend the classical Euler-Lagrange equations and the Hamiltonian formalism. The resulting dynamical equations seem to be compatible with those found in the literature, specially with mass-dependent and with nonlinear equations for systems in classical and quantum mechanics. Examples are presented to illustrate applications of the formulation. Also, the conserved Noether current is worked out.
Variational Approach and Deformed Derivatives
Weberszpil, José
2015-01-01
Recently, we have demonstrated that there exists a possible relationship between q-deformed algebras in two different contexts of Statistical Mechanics, namely, the Tsallis' framework and the Kaniadakis' scenario, with a local form of fractional-derivative operators for fractal media, the so-called Hausdorff derivatives, mapped into a continuous medium with a fractal measure. Here, in this paper, we present an extension of the traditional calculus of variations for systems containing deformed-derivatives embedded into the Lagrangian and the Lagrangian densities for classical and field systems. The results extend the classical Euler-Lagrange equations and the Hamiltonian formalism. The resulting dynamical equations seem to be compatible with those found in the literature, specially with mass-dependent and with nonlinear equations for systems in classical and quantum mechanics. Examples are presented to illustrate applications of the formulation. Also, the conserved Nether current, are worked out.
A K Gupta; R G Shandil
2011-11-01
We utilize the reformulated equations of the classical theory, as derived by Banerjee et al.(J. Math. Anal. Appl. 175 (1993) 458), to establish mathematically, the existence of hydrodynamic instability in single diffusive bottom heavy systems, when considered in the more general framework of the boundary conditions of the type specified by Beavers and Joseph (J. Fluid Mech. 30 (1967) 197), in the parameter regime $T_0_2>1$, where $T_0$ and 2 being some properly chosen mean temperature and coefficient of specific heat (at constant volume) variation due to temperature variation respectively.
Variation in Metaphor Variation in Metaphor
Zóltan Kövecses
2010-05-01
Full Text Available
Cognitive linguists have so far paid a great deal of attention to the emarkable universality of many conceptual metaphors. However, their theories fail to account for the equally impressive diversity of metaphorical conceptualization both across and within cultures. The present paper is an attempt to lay down the foundations of a theory of metaphor that is capable of simultaneously accounting for both universality and variation in metaphor.
Cognitive linguists have so far paid a great deal of attention to the emarkable universality of many conceptual metaphors. However, their theories fail to account for the equally impressive diversity of metaphorical conceptualization both across and within cultures. The present paper is an attempt to lay down the foundations of a theory of metaphor that is capable of simultaneously accounting for both universality and variation in metaphor.
Auxiliary principle and fuzzy variational-like inequalities
Zeng LC
2005-01-01
Full Text Available The purpose of this paper is to introduce the concept of fuzzy variational-like inequalities and to study the existence problem and the iterative approximation problem for solutions of certain kinds of fuzzy variational-like inequalities in Hilbert spaces. By using the general auxiliary principle technique, Ky Fan's KKM theorem, Nadler's fixed point theorem, and some new analytic techniques, some existence theorems and some iterative approximation schemes for solving this kind of fuzzy variational-like inequalities are established. The results presented in this paper are new and they generalize, improve, and unify a number of recent results.
Eifler, Tobias; Boorla, Srinivasa Murthy; Howard, Thomas J.
2016-01-01
by the availability of sophisticated methods and tools alone, but does evidently also depend on the accuracy of the input information used. As existing approaches for the description of manufacturing variation focus however, almost exclusively, on monitoring and controlling production processes, there is frequently...
Variational integrators for nonvariational partial differential equations
Kraus, Michael; Maj, Omar
2015-08-01
Variational integrators for Lagrangian dynamical systems provide a systematic way to derive geometric numerical methods. These methods preserve a discrete multisymplectic form as well as momenta associated to symmetries of the Lagrangian via Noether's theorem. An inevitable prerequisite for the derivation of variational integrators is the existence of a variational formulation for the considered problem. Even though for a large class of systems this requirement is fulfilled, there are many interesting examples which do not belong to this class, e.g., equations of advection-diffusion type frequently encountered in fluid dynamics or plasma physics. On the other hand, it is always possible to embed an arbitrary dynamical system into a larger Lagrangian system using the method of formal (or adjoint) Lagrangians. We investigate the application of the variational integrator method to formal Lagrangians, and thereby extend the application domain of variational integrators to include potentially all dynamical systems. The theory is supported by physically relevant examples, such as the advection equation and the vorticity equation, and numerically verified. Remarkably, the integrator for the vorticity equation combines Arakawa's discretisation of the Poisson brackets with a symplectic time stepping scheme in a fully covariant way such that the discrete energy is exactly preserved. In the presentation of the results, we try to make the geometric framework of variational integrators accessible to non specialists.
Existence and non-existence results for a nonlinear heat equation
Canan Celik
2007-02-01
Full Text Available In this study, we consider the nonlinear heat equation $$displaylines{ u_{t}(x,t = Delta u(x,t + u(x,t^p quad hbox{in } Omega imes (0,T,cr Bu(x,t = 0 quad hbox{on } partialOmega imes (0,T,cr u(x,0 = u_0(x quad hbox{in } Omega,}$$ with Dirichlet and mixed boundary conditions, where $Omega subset mathbb{R}^n$ is a smooth bounded domain and $p = 1+ 2 /n$ is the critical exponent. For an initial condition $u_0 in L^1$, we prove the non-existence of local solution in $L^1$ for the mixed boundary condition. Our proof is based on comparison principle for Dirichlet and mixed boundary value problems. We also establish the global existence in $L^{1+epsilon}$ to the Dirichlet problem, for any fixed $epsilon > 0$ with $|u_0|_{1+epsilon}$ sufficiently small.
On the existence of guided acoustic waves at rectangular anisotropic edges.
Pupyrev, Pavel D; Lomonosov, Alexey M; Nikodijevic, Aleksandar; Mayer, Andreas P
2016-09-01
The existence of acoustic waves with displacements localized at the tip of an isotropic elastic wedge was rigorously proven by Kamotskii, Zavorokhin and Nazarov. This proof, which is based on a variational approach, is extended to rectangular anisotropic wedges. For two high-symmetry configurations of rectangular edges in elastic media with tetragonal symmetry, a criterion is derived that allows identifying the boundary between the regions of existence for wedge modes of even and odd symmetry in regions of parameter space, where even- and odd-symmetry modes do not exist simultaneously. Furthermore, rectangular edges with non-equivalent surfaces are analyzed, and it is shown that at rectangular edges of cubic elastic media with one (110) surface and one (001) surface, a tip-localized guided wave always exists, apart from special cases that are characterized.
40 CFR 405.64 - Pretreatment standards for existing sources.
2010-07-01
...) EFFLUENT GUIDELINES AND STANDARDS DAIRY PRODUCTS PROCESSING POINT SOURCE CATEGORY Natural and Processed Cheese Subcategory § 405.64 Pretreatment standards for existing sources. Any existing source subject...
Black Hole Caught Zapping Galaxy into Existence?
2009-11-01
, construction and operation of powerful ground-based observing facilities enabling astronomers to make important scientific discoveries. ESO also plays a leading role in promoting and organising cooperation in astronomical research. ESO operates three unique world-class observing sites in Chile: La Silla, Paranal and Chajnantor. At Paranal, ESO operates the Very Large Telescope, the world's most advanced visible-light astronomical observatory. ESO is the European partner of a revolutionary astronomical telescope ALMA, the largest astronomical project in existence. ESO is currently planning a 42-metre European Extremely Large optical/near-infrared Telescope, the E-ELT, which will become "the world's biggest eye on the sky".
Structural variations in pig genomes
Paudel, Y.
2015-01-01
Abstract Paudel, Y. (2015). Structural variations in pig genomes. PhD thesis, Wageningen University, the Netherlands Structural variations are chromosomal rearrangements such as insertions-deletions (INDELs), duplications, inversions, translocations, and copy number variations (CNVs
Łukaszewicz, Grzegorz
2012-01-01
We consider a two-dimensional nonstationary Navier-Stokes shear flow with a subdifferential boundary condition on a part of the boundary of the flow domain, namely, with a boundary driving subject to the Tresca law. There exists a unique global in time solution of the considered problem which is governed by a variational inequality. Our aim is to prove the existence of a global attractor of a finite fractional dimension and of an exponential attractor for the associated semigroup. We use the method of $l$-trajectories. This research is motivated by a problem from lubrication theory.
Existence of Young measure solutions of a class of singular diffusion equations
无
2002-01-01
The first initial-boundary value problem of a class of singular diffusion equations with the flux sublinear growth and the potential without convexity is investigated. Such equations may be strongly degenerate, singular and forward-backward. Inspired by the idea in a recent work of Demoulini, we first discuss the regular case by introducing the Young measure solutions and prove the existence of such solutions. Consequently, we approximate the extreme case by the method of regularization. By means of some uniform estimates and some techniques, the existence of Young measure solutions with bounded variation is established.
Zhang Zhijiun
2008-01-01
By Karamata regular variation theory and constructing comparison functions, the author shows the existence and global optimal asymptotic behaviour of solutions for a semilinear elliptic problem △u = k(x)g(u),u>0, x∈Ω, u|(e)Ω = +∞, where Ω is a bounded domain with smooth boundary in RN; g ∈ C1[0,∞), g(0) = g'(0) = 0, and there exists p > 1, such that lims→∞ g(sξ)/g(s)=ξp, (A)ξ > 0, and k∈Cαloc(Ω) is non-negative non-trivial in Ω which may be singular on the boundary.
Variations in government contract in Malaysia
Jaspal Singh Nachatar
2010-12-01
Full Text Available The complexity of construction works means that it is hardly possible to complete a project without changes to the plans or the construction process itself. There can only be a minority of contracts of any size in which the subject matter when completed is identical in every respect with what was contemplated at the outset. As such, variations are inevitable in even the best-planned contracts. This study is attempted to examine the ways a variation was formed in law and project, in finding out whether the Standard Form of Contract used in Malaysia particularly the government Public Works Department (PWD form has been utilized to the best level in variation cases. Additionally, this study examined the benefits of variations to parties in contract and also provides suggestions and assumptions in an effort to contribute solutions to issues and problem detected. The research methodology used in this study was an extensive review of relevant literature, case study, empirical questionnaires and structured interviews and general observations based on experience and surroundings. The academic study approach incorporated stages such as initial understanding, data and information gathering, analysis of data, findings and conclusion and general suggestions in the study. The major findings of this study, among others, revealed that the existences of variations are common in projects. The main cause of variations was due to client request because of inadequate project objectives for the designer to develop comprehensive design. Besides, the analysis pointed out that the government form of contract the Public Works Department (PWD 203/203A can help in overcoming projects with variation because of the clear defined procedure. This study also found that proper planning and coordination at tender stage can minimize the risk of ‘unwanted’ variations. In conclusion, this study recommended that future research should be done in design and build based contract
Process Variations and Probabilistic Integrated Circuit Design
Haase, Joachim
2012-01-01
Uncertainty in key parameters within a chip and between different chips in the deep sub micron era plays a more and more important role. As a result, manufacturing process spreads need to be considered during the design process. Quantitative methodology is needed to ensure faultless functionality, despite existing process variations within given bounds, during product development. This book presents the technological, physical, and mathematical fundamentals for a design paradigm shift, from a deterministic process to a probability-orientated design process for microelectronic circuits. Readers will learn to evaluate the different sources of variations in the design flow in order to establish different design variants, while applying appropriate methods and tools to evaluate and optimize their design. Trains IC designers to recognize problems caused by parameter variations during manufacturing and to choose the best methods available to mitigate these issues during the design process; Offers both qual...
Discrete Variational Optimal Control
Jimenez, Fernando; de Diego, David Martin
2012-01-01
This paper develops numerical methods for optimal control of mechanical systems in the Lagrangian setting. It extends the theory of discrete mechanics to enable the solutions of optimal control problems through the discretization of variational principles. The key point is to solve the optimal control problem as a variational integrator of a specially constructed higher-dimensional system. The developed framework applies to systems on tangent bundles, Lie groups, underactuated and nonholonomic systems with symmetries, and can approximate either smooth or discontinuous control inputs. The resulting methods inherit the preservation properties of variational integrators and result in numerically robust and easily implementable algorithms. Several theoretical and a practical examples, e.g. the control of an underwater vehicle, will illustrate the application of the proposed approach.
Discrete Variational Optimal Control
Jiménez, Fernando; Kobilarov, Marin; Martín de Diego, David
2013-06-01
This paper develops numerical methods for optimal control of mechanical systems in the Lagrangian setting. It extends the theory of discrete mechanics to enable the solutions of optimal control problems through the discretization of variational principles. The key point is to solve the optimal control problem as a variational integrator of a specially constructed higher dimensional system. The developed framework applies to systems on tangent bundles, Lie groups, and underactuated and nonholonomic systems with symmetries, and can approximate either smooth or discontinuous control inputs. The resulting methods inherit the preservation properties of variational integrators and result in numerically robust and easily implementable algorithms. Several theoretical examples and a practical one, the control of an underwater vehicle, illustrate the application of the proposed approach.
Variation and Synthetic Speech
Miller, C; Massey, N; Miller, Corey; Karaali, Orhan; Massey, Noel
1997-01-01
We describe the approach to linguistic variation taken by the Motorola speech synthesizer. A pan-dialectal pronunciation dictionary is described, which serves as the training data for a neural network based letter-to-sound converter. Subsequent to dictionary retrieval or letter-to-sound generation, pronunciations are submitted a neural network based postlexical module. The postlexical module has been trained on aligned dictionary pronunciations and hand-labeled narrow phonetic transcriptions. This architecture permits the learning of individual postlexical variation, and can be retrained for each speaker whose voice is being modeled for synthesis. Learning variation in this way can result in greater naturalness for the synthetic speech that is produced by the system.
Variational electrodynamics of Atoms
De Luca, Jayme
2013-01-01
We study extrema with velocity discontinuities for the variational electromagnetic two-body problem. Along $C^2$ segments, these broken extrema satisfy the Euler-Lagrange equations of the variational principle, which are neutral differential delay equations with state-dependent deviating arguments. At points where accelerations are not defined and velocities are discontinuous, broken extrema satisfy Weierstrass-Erdmann corner conditions that energies and momenta are continuous. Here we construct periodic broken extrema near the $C^{\\infty}$ two-body circular orbits, using piecewise-defined $C^2$ solutions of the neutral differential delay equations along regular segments and a variational approximation for the boundary-layer segments. Broken periodic extrema with an integer number of corner points bifurcate from a discrete set of circular orbits, with scales defined by the Weierstrass-Erdmann corner conditions. We consider the three cases of hydrogen, muonium and positronium atoms. In each case the broken ext...
Khandige, Surabhi; Møller-Jensen, Jakob
2016-01-01
Surface fimbriae of pathogenic Escherichia coli facilitate sensing, adhesion and even invasion of host epithelial cells. While it is known that the pathogen has the potential to express a plethora of fimbrial variants susceptible to rapid phase ON/OFF variation, it is an open question if the fimb......Surface fimbriae of pathogenic Escherichia coli facilitate sensing, adhesion and even invasion of host epithelial cells. While it is known that the pathogen has the potential to express a plethora of fimbrial variants susceptible to rapid phase ON/OFF variation, it is an open question...... if the fimbrial diversity seen at the population level is the product of random stochasticity or a concerted effort based on active communication. Here we discuss the possibility of a mechanism alternative to a stochastic fimbrial phase variation model affecting the dynamics of a heterogeneous population....
20 CFR 718.202 - Determining the existence of pneumoconiosis.
2010-04-01
... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Determining the existence of pneumoconiosis... existence of pneumoconiosis. (a) A finding of the existence of pneumoconiosis may be made as follows: (1) A... the existence of pneumoconiosis. Except as otherwise provided in this section, where two or more...
Game arguments in some existence theorems of Friedberg numberings
Imamura, Takuma
2015-01-01
We provide game-theoretic proofs of some well-known existence theorems of Friedberg numberings, including (1) the existence of two incomparable Friedberg numberings; (2) the existence of a uniformly c.e. sequence of pairwise incomparable Friedberg numberings; (3) the existence of a uniformly c.e. independent sequence of Friedberg numberings.
Splines and variational methods
Prenter, P M
2008-01-01
One of the clearest available introductions to variational methods, this text requires only a minimal background in calculus and linear algebra. Its self-contained treatment explains the application of theoretic notions to the kinds of physical problems that engineers regularly encounter. The text's first half concerns approximation theoretic notions, exploring the theory and computation of one- and two-dimensional polynomial and other spline functions. Later chapters examine variational methods in the solution of operator equations, focusing on boundary value problems in one and two dimension
Seasonal Variation in Epidemiology
Marrero, Osvaldo
2013-01-01
Seasonality analyses are important in medical research. If the incidence of a disease shows a seasonal pattern, then an environmental factor must be considered in its etiology. We discuss a method for the simultaneous analysis of seasonal variation in multiple groups. The nuts and bolts are explained using simple trigonometry, an elementary…
Variational transition state theory
Truhlar, D.G. [Univ. of Minnesota, Minneapolis (United States)
1993-12-01
This research program involves the development of variational transition state theory (VTST) and semiclassical tunneling methods for the calculation of gas-phase reaction rates and selected applications. The applications are selected for their fundamental interest and/or their relevance to combustion.
Appell, Jürgen; Merentes Díaz, Nelson José
2013-01-01
This monographis a self-contained exposition of the definition and properties of functionsof bounded variation and their various generalizations; the analytical properties of nonlinear composition operators in spaces of such functions; applications to Fourier analysis, nonlinear integral equations, and boundary value problems. The book is written for non-specialists. Every chapter closes with a list of exercises and open problems.
Progress in variational methods
2008-01-01
@@ The International Conference on Variational Methods (ICVAM) was held from May 20th to 26th in 2007 at the Chern Institute of Mathematics, Nankai University, Tianjin, China. Twenty eight invited speakers from ten countries and areas worldwide gave their lectures at the conference.
Variation and Linguistic Theory.
Bailey, Charles-James N.
This volume presents principles and models for describing language variation, and introduces a time-based, dynamic framework for linguistic description. The book first summarizes some of the problems of grammatical description encountered from Saussure through the present and then outlines possibilities for new descriptions of language which take…
A Probabilistic Approach to Second Order Variational Inequalities with Bilateral Constraints
Mrinal K Ghosh; K S Mallikarjuna Rao
2003-11-01
We study a class of second order variational inequalities with bilateral constraints. Under certain conditions we show the existence of a unique viscosity solution of these variational inequalities and give a stochastic representation to this solution. As an application, we study a stochastic game with stopping times and show the existence of a saddle point equilibrium.
Genetic analysis of environmental variation
Hill, W.G.; Mulder, H.A.
2010-01-01
Environmental variation (VE) in a quantitative trait – variation in phenotype that cannot be explained by genetic variation or identifiable genetic differences – can be regarded as being under some degree of genetic control. Such variation may be either between repeated expressions of the same trait
Genetic analysis of environmental variation
Hill, W.G.; Mulder, H.A.
2010-01-01
Environmental variation (VE) in a quantitative trait – variation in phenotype that cannot be explained by genetic variation or identifiable genetic differences – can be regarded as being under some degree of genetic control. Such variation may be either between repeated expressions of the same trait
International symposium on seismic evaluation of existing nuclear facilities
Orbovic, N.; Bouchon, M. [Institut de Radioprotection et de Surete Nucleaire, IRSN, 92 - Fontenay aux Roses (France); Vendel, J.; Gelain, T. [IRSN/DPEA/SERAC, 91 - Gif sur Yvette (France)
2003-10-01
revealed a strong influence of the slab plates and a torsion in the structure. Also, masonry in-fills can significantly alter the seismic behavior of the building. The building is being subjected to a very large retrofit program submitted for approval to IRSN and the Nuclear Safety Authority. The acceptance criteria used to define deficiencies and to retrofit the building were design criteria. Evaluation of existing nuclear facility structures must be conducted with the appropriate level of conservatism. Therefore, even though modern performance-based evaluation procedures for conventional structures are available, they must be rigorously examined before they are used to evaluate nuclear facility structures. This paper presents selected results of an evaluation of various nonlinear static and dynamic demand analysis and FEMA-356 capacity measures on a test-bed nuclear facility reinforced concrete frame structure built in 1960's. It is shown that these modern procedures can be used. Furthermore, they revealed deficiencies of the test-bed structure that could not be easily found using the conventional linear-and-elastic evaluation methods. Nevertheless, more work is needed to calibrate these new procedures for the risk reduction levels required for nuclear facilities before they can be used in nuclear facility design and evaluation practice. The test program consisted of mechanical testy performed on reinforced concrete walls subjected to alternating shear loads. The aim of the program was to define crack geometry (length, width, and spacing). Tests were carried out on 3 low-rise reinforced concrete walls with varying percentages of rebars. Each wall was subjected to a sequence of three increasing loads. One of the three walls was loaded to failure. The main results of the program were measurements of displacement as a function of horizontal force (displacements, variations in diagonal lengths), cracking states during the loading cycle, and deformation of rebars. The
Morphological Variation in the Adult Hard Palate and Posterior Pharyngeal Wall
Lammert, Adam; Proctor, Michael; Narayanan, Shrikanth
2013-01-01
Purpose: Adult human vocal tracts display considerable morphological variation across individuals, but the nature and extent of this variation has not been extensively studied for many vocal tract structures. There exists a need to analyze morphological variation and, even more basically, to develop a methodology for morphological analysis of the…
On functions of bounded variation
Aistleitner, Christoph; Pausinger, Florian; Svane, Anne Marie; Tichy, Robert F.
2015-01-01
The recently introduced concept of $\\mathcal{D}$-variation unifies previous concepts of variation of multivariate functions. In this paper, we give an affirmative answer to the open question from Pausinger \\& Svane (J. Complexity, 2014) whether every function of bounded Hardy--Krause variation is Borel measurable and has bounded $\\mathcal{D}$-variation. Moreover, we show that the space of functions of bounded $\\mathcal{D}$-variation can be turned into a commutative Banach algebra.
Rosenblatt, Heather
2011-01-01
Through Borel summation methods, we analyze two different variations of the Navier-Stokes equation --the Boussinesq equation and the magnetic Benard equation. This method has previously been applied to the Navier-Stokes equation. We prove that an equivalent system of integral equations in each case has a unique solution, which is exponentially bounded for p in R^{+}, p being the Laplace dual variable of 1/t. This implies the local existence of a classical solution in a complex t-region that includes a real positive time (t)-axis segment. In this formalism, global existence of PDE solutions becomes a problem of asymptotics in the dual variable. Further, it is shown that within the time interval of existence, for analytic initial data and forcing, the solution remains analytic and has the same analyticity strip width. Under these conditions, the solution is Borel summable, implying that the formal series in time is Gevrey-1 asymptotic for small t.
Human immune system variation.
Brodin, Petter; Davis, Mark M
2017-01-01
The human immune system is highly variable between individuals but relatively stable over time within a given person. Recent conceptual and technological advances have enabled systems immunology analyses, which reveal the composition of immune cells and proteins in populations of healthy individuals. The range of variation and some specific influences that shape an individual's immune system is now becoming clearer. Human immune systems vary as a consequence of heritable and non-heritable influences, but symbiotic and pathogenic microbes and other non-heritable influences explain most of this variation. Understanding when and how such influences shape the human immune system is key for defining metrics of immunological health and understanding the risk of immune-mediated and infectious diseases.
Existence and uniqueness of positive eigenfunctions for certain eigenvalue systems
Xue, Ru-Ying; Yang, Yi-Min
2004-01-01
The existence and uniqueness of eigenvalues and positive eigenfunctions for some quasilinear elliptic systems are considered. Some necessary and sufficient conditions which guarantee the existence and uniqueness of eigenvalues and positive eigenfunctions are given.
40 CFR 417.64 - Pretreatment standards for existing sources.
2010-07-01
...) EFFLUENT GUIDELINES AND STANDARDS SOAP AND DETERGENT MANUFACTURING POINT SOURCE CATEGORY Manufacture of Soap Flakes and Powders Subcategory § 417.64 Pretreatment standards for existing sources. Any existing...
33 CFR 329.10 - Existence of obstructions.
2010-07-01
... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Existence of obstructions. 329.10... DEFENSE DEFINITION OF NAVIGABLE WATERS OF THE UNITED STATES § 329.10 Existence of obstructions. A stream may be navigable despite the existence of falls, rapids, sand bars, bridges, portages,...
A NOTE ON THE EXISTENCE OF SINGULAR INTEGRALS
无
2001-01-01
In this note the existence of a singular integral operator T acting on Lipα(Rn)spaces is studied. Suppose f∈Lipα(Rn)(0＜α＜1). If Tf (xo) exists for a single point xo∈Rn, then Tf(x)exists everywhere for x∈Rn and Tf∈Lipα(Rn).
12 CFR 543.14 - Continuity of existence.
2010-01-01
... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Continuity of existence. 543.14 Section 543.14... ASSOCIATIONS-INCORPORATION, ORGANIZATION, AND CONVERSION Conversion § 543.14 Continuity of existence. The corporate existence of an association converting under this part shall continue in its successor....
Optimization of existing heat-integrated refinery distillation systems
Gadalla, M.; Jobson, M.; Smith, R.
2003-01-01
Existing refinery distillation systems are highly energy-intensive, and have complex column configurations that interact strongly with the associated heat exchanger network. An optimization approach is developed for existing refinery distillation processes. The optimization framework includes shortcut models developed for the simulation of the existing distillation column, and a retrofit shortcut model for the heat exchanger network. The existing distillation process is optimized by changing key operating parameters, while simultaneously accounting for hydraulic limitations and the design and the performance of the existing heat exchanger network. A case study shows that a reduction in energy consumption and operating costs of over 25% can be achieved. (Author)
无
2010-01-01
By different fixed point theorems in cones, sufficient conditions for the existence and multiple existence of positive solutions to a class of second-order multi-point boundary value problem for dynamic equation on time scales are obtained.
ON THE SINGULAR VARIATIONAL PROBLEMS
谭经刚; 杨健夫
2004-01-01
The authors deal with the singular variational problem S(a,b,λ0):=infu∈E,u(≡／)0 ∫RN(||X|-a(△)u|m+∫|x|-(a+1)m|u|m)dx/(∫RN||X|-bU|P dx)m/p as well as (S)=(S)(a,b,λ1,λ2):=u,ν,E∈,u(u,ν)(≡／)(1,1) ∫RN J(u,ν)dx/(∫RN|x|-bp|u|α|ν|βdx)m/p, whereJ(u, v) = ||x|- au|m + λ1|x|- (a+1)m|u|m + ||x|- av|m + λ2|x|- (a+1)m|v|m,N ≥ m+ 1 ＞ 2, 0 ≤ a ＜ N-m/m, a ≤ b ＜ a+ 1 and p = p(a,b) = α+β =Nm/N-m+m(b-a), α, β≥ 1, E = D1,mα(RN). The aim of this paper is to show the existence of minimizer for S(a, b, A0) and S(a, b, λ1, λ2).
Solvability of Extended General Strongly Mixed Variational Inequalities
Balwant Singh Thakur
2013-10-01
Full Text Available In this paper, a new class of extended general strongly mixed variational inequalities is introduced and studied in Hilbert spaces. An existence theorem of solution is established and using resolvent operator technique, a new iterative algorithm for solving the extended general strongly mixed variational inequality is suggested. A convergence result for the iterative sequence generated by the new algorithm is also established.
A Variational Approach to Particles in Lipid Membranes
Elliott, Charles M.; Gräser, Carsten; Hobbs, Graham; Kornhuber, Ralf; Wolf, Maren-Wanda
2016-11-01
A variety of models for the membrane-mediated interaction of particles in lipid membranes, mostly well-established in theoretical physics, is reviewed from a mathematical perspective. We provide mathematically consistent formulations in a variational framework, relate apparently different modelling approaches in terms of successive approximation, and investigate existence and uniqueness. Numerical computations illustrate that the new variational formulations are directly accessible to effective numerical methods.
Patient health causes substantial portion of geographic variation in Medicare costs.
Collado, Megan
2013-10-01
Key findings. (1) Substantial geographic variation exists in Medicare costs, but to determine the source and extent of this variation requires proper accounting for population health differences. (2) While physician practice patterns likely affect Medicare geographic cost variations, population health explains at least 75 to 85 percent of the variations—more than previously estimated. (3) Policy strategies should consider the magnitude of the impact of beneficiary health status on Medicare costs in order to address geographic variation.
An improved variational method
ZENG Zhuo-Quan; SHEN Peng-Nian; DING Yi-Bing
2009-01-01
In order to improve the unitarity of the S-matrix, an improved variational formulism is derived by proposing new generating functionals and adopting proper asymptotic boundary conditions for trial relative wave functions. The formulas with the weighted line-column balance for the single-channel and multi-channel scatterings, where the non-central interaction is implicitly considered, are presented. A numerical check is performed with a soluble model in a four coupled channel scattering problem. The result shows that the high accuracy and the unitarity of the S-matrix are reached.
I-Wen Sun
2012-06-01
Full Text Available Elderly patients are vulnerable to the adverse neurological effects of antipsychotics, particularly Parkinsonian symptoms and tardive dyskinesia. This vulnerability in the elderly becomes complex and unpredictable when aripiprazole is prescribed to replace other second-generation or first-generation antipsychotics. This report describes a 69-year-old female schizophrenic patient, who received aripiprazole after using a few antipsychotics, including the first- and second-generation ones. The tardive dyskinesia developed 6 weeks after switching to aripiprazole but subsided 4 weeks later when stopping the concurrent amantadine and decreasing the dosage of trihexyphenidyl. However, Parkinsonian symptoms developed insidiously thereafter, which remitted after the dosage of trihexyphenidyl was increased again. The possible mechanisms of the alternated adverse neurological events after a switch to aripiprazole in the chronic elderly psychosis are discussed.
Safavi, Kyan C.; Dharmarajan, Kumar; Kim, Nancy; Strait, Kelly M.; Li, Shu-Xia; Chen, Serene I.; Lagu, Tara; Krumholz, Harlan M.
2013-01-01
Background Despite increasing attention on reducing relatively costly hospital practices while maintaining the quality of care, few studies have examined how hospitals use the intensive care unit (ICU), a high-cost setting, for patients admitted with heart failure (HF). We characterized hospital patterns of ICU admission for patients with HF and determined their association with the use of ICU-level therapies and patient outcomes. Methods and Results We identified 166,224 HF discharges from 341 hospitals in the 2009–10 Premier Perspective® database. We excluded hospitals with transfers. We defined ICU as including medical ICU, coronary ICU, and surgical ICU. We calculated the percent of patients admitted directly to an ICU. We compared hospitals in the top-quartile (high ICU admission) with the remaining quartiles. The median percentage of ICU admission was 10% (Interquartile Range 6% to 16%; range 0% to 88%). In top-quartile hospitals, treatments requiring an ICU were used less often: percentage of ICU days receiving mechanical ventilation (6% top quartile versus 15% others), non-invasive positive pressure ventilation (8% versus 19%), vasopressors and/or inotropes (9% versus 16%), vasodilators (6% versus 12%), and any of these interventions (26% versus 51%). Overall HF in-hospital risk standardized mortality was similar (3.4% versus 3.5%; P = 0.2). Conclusions ICU admission rates for HF varied markedly across hospitals and lacked association with in-hospital risk-standardized mortality. Greater ICU use correlated with fewer patients receiving ICU interventions. Judicious ICU use could reduce resource consumption without diminishing patient outcomes. PMID:23355624
Murphy, Andrew
2012-01-01
peer-reviewed Background: There is a paucity of research profiling the anthropometric measures and physical performance indicators of hurling athletes. Such profiles are essential to optimising the physical preparation structures of hurling athletes. Methods: A battery of tests profiling the anthropometric measures and physical performance indicators of 95 hurling athletes from three different levels of participation, senior elite (n1=34), senior sub- elite (n2=28) & junior elite (n3=33...
无
2000-01-01
The exact monotone twist map of infinite cylinders in the Birkhoff region of instability is studied. A variational method based on Aubry-Mather theory is used to discover infinitely many non-Birkhoff periodic orbits of fixed rotation number sufficiently close to some irrational number for which the angular invariant circle does not exist.
Taking Stock of Regulatory Variation.
Maurano, Matthew T; Stamatoyannopoulos, John A
2015-07-29
Three recent studies measure individual variation in regulatory DNA accessibility. What do they tell us about the prospects of assessing variation in single cells and across populations? Copyright © 2015 Elsevier Inc. All rights reserved.
Fádorò Jacob Oludare
2014-07-01
Full Text Available Language contact among Akokoid, Yoruboid and Edoid has resulted in extensive borrowing from Yoruboid and Edoid to Akokoid. Thus, the speech forms subsumed under Akokoid exhibit lexical items which are similar to Yoruboid and Edoid. To the best of our knowledge, no other scholarly work has addressed the concept ‘lexical variation in these speech forms, hence, the need for this present effort. Twenty lexical items were carefully selected for analysis in this paper. Data were elicited from 34 informants who are competent speakers of Akokoid. Apart from the linguistic data, these informants, including traditional rulers, supplied us with historical facts about the migration patterns of the progenitors of Akokoid. The historical facts coupled with the linguistic data helped us to arrive at the conclusion that some of the words used in contemporary Akokoid found their way into Akokoid as a result of the contact between Akokoid and their neighbours, Yoruboid and Edoid.Keywords: Akokoid, Language Contact, Lexical Variation, Yoruboid, Edoid
Multifunctions of bounded variation
Vinter, R. B.
2016-02-01
Consider control systems described by a differential equation with a control term or, more generally, by a differential inclusion with velocity set F (t , x). Certain properties of state trajectories can be derived when it is assumed that F (t , x) is merely measurable w.r.t. the time variable t. But sometimes a refined analysis requires the imposition of stronger hypotheses regarding the time dependence. Stronger forms of necessary conditions for minimizing state trajectories can be derived, for example, when F (t , x) is Lipschitz continuous w.r.t. time. It has recently become apparent that significant addition properties of state trajectories can still be derived, when the Lipschitz continuity hypothesis is replaced by the weaker requirement that F (t , x) has bounded variation w.r.t. time. This paper introduces a new concept of multifunctions F (t , x) that have bounded variation w.r.t. time near a given state trajectory, of special relevance to control. We provide an application to sensitivity analysis.
Chertkov, Michael [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Ahn, Sungsoo [Korea Advanced Inst. Science and Technology (KAIST), Daejeon (Korea, Republic of); Shin, Jinwoo [Korea Advanced Inst. Science and Technology (KAIST), Daejeon (Korea, Republic of)
2017-05-25
Computing partition function is the most important statistical inference task arising in applications of Graphical Models (GM). Since it is computationally intractable, approximate methods have been used to resolve the issue in practice, where meanfield (MF) and belief propagation (BP) are arguably the most popular and successful approaches of a variational type. In this paper, we propose two new variational schemes, coined Gauged-MF (G-MF) and Gauged-BP (G-BP), improving MF and BP, respectively. Both provide lower bounds for the partition function by utilizing the so-called gauge transformation which modifies factors of GM while keeping the partition function invariant. Moreover, we prove that both G-MF and G-BP are exact for GMs with a single loop of a special structure, even though the bare MF and BP perform badly in this case. Our extensive experiments, on complete GMs of relatively small size and on large GM (up-to 300 variables) confirm that the newly proposed algorithms outperform and generalize MF and BP.
Urban building recognition during significant temporal variations
Nguyen, Phuong Giang; Andersen, Hans Jørgen
2008-01-01
In literature, existing researches on building recognition mainly concentrate on scales, rotations, and viewpoints variance. In urban environment, large temporal variations of weather and lighting conditions should also be considered as major challenges for robust recognition. For instances......, there are differences between images captured during daytime and nighttime, especially significant changes in building appearances between seasons because of the differences in light setting. To date, these large temporal variation issues have not been fully investigated. In this paper, we therefore focus...... on constructing a system that deals with the temporal difference factors in recognizing urban buildings. In order to build such a system, two main criteria are raised, namely the efficiency of the recognition algorithm and the speed for interactive search purpose. For recognition purpose, we exploit the MOPS...
Variational Theory for Chandrasekharaiah Thermopizoelectricity
JiHuanHE
1999-01-01
Via the semi-inverse method of establishing generalized variational principle for physical problems,a classical variational model(non Gurtin-type and not involving convolutions) for Chandrasekharaiah thermopiezoelectricity is established directly from the governing equations.The present theory aims at providing a more complete theoretical basis for the variational-based finite element applications and variational-based meshless method(element-free method).
Plastic variational principle based on the least work consumption principle
唐松花; 罗迎社; 周筑宝; 王智超
2008-01-01
Plastic variational principles are foundation to solve the boundary-value problems of plastic mechanics with the variational method(or energy method) and finite element method.The most convenient way of establishing different kinds of variational principles is to set up the extreme principle related to the studied problem.Based on a general new extreme principle-the Least work consumption principle,the variational principles of the rigid-plastic and rigid-viscoplastic material were derived.In comparison with existing methods,the method in this paper is more clear and direct,and the physical meaning is clear-cut.This method can offer a new way for establishing other kinds of variational principles.
School variation in asthma: compositional or contextual?
Tracy K Richmond
Full Text Available BACKGROUND: Childhood asthma prevalence and morbidity have been shown to vary by neighborhood. Less is known about between-school variation in asthma prevalence and whether it exists beyond what one might expect due to students at higher risk of asthma clustering within different schools. Our objective was to determine whether between-school variation in asthma prevalence exists and if so, if it is related to the differential distribution of individual risk factors for and correlates of asthma or to contextual influences of schools. METHODS: Cross-sectional analysis of 16,640 teens in grades 7-12 in Wave 1 (data collected in 1994-5 of the National Longitudinal Study of Adolescent Health. Outcome was current diagnosis of asthma as reported by respondents' parents. Two-level random effects models were used to assess the contribution of schools to the variance in asthma prevalence before and after controlling for individual attributes. RESULTS: The highest quartile schools had mean asthma prevalence of 21.9% compared to the lowest quartile schools with mean asthma prevalence of 7.1%. In our null model, the school contributed significantly to the variance in asthma (sigma(u0(2 = 0.27, CI: 0.20, 0.35. Controlling for individual, school and neighborhood attributes reduced the between-school variance modestly (sigma(u0(2 = 0.19 CI: 0.13-0.29. CONCLUSION: Significant between-school variation in current asthma prevalence exists even after controlling for the individual, school and neighborhood factors. This provides evidence for school level contextual influences on asthma. Further research is needed to determine potential mechanisms through which schools may influence asthma outcomes.
Existence of Almost Resolvable Directed 7-Cycle Systems
无
2005-01-01
Let ARDkCS(v) denote an almost resolvable directed k-cycle system of order v. It is clear that a necessary condition for the existence of an ARDkCS(v) is v≡1(mod k). For k= 3,4,5 and 6, the existence of an ARDkCS(v) had been completely solved. This paper shows that there exists an ARD7CS(v) if and only if v≡1(mod 7) and v≥8.
Existence and uniqueness theorem for ODE: an overview
Poria, Swarup; Dhiman, Aman
2016-01-01
The study of existence and uniqueness of solutions became important due to the lack of general formula for solving nonlinear ordinary differential equations (ODEs). Compact form of existence and uniqueness theory appeared nearly 200 years after the development of the theory of differential equation. In the article, we shall discuss briefly the differences between linear and nonlinear first order ODE in context of existence and uniqueness of solutions. Special emphasis is given on the Lipschit...
Existence, uniqueness and stability of solutions of generalized Tikhonov-Phillips functionals
Mazzieri, Gisela L; Temperini, Karina G
2011-01-01
The Tikhonov-Phillips method is widely used for regularizing ill-posed inverse problems mainly due to the simplicity of its formulation as an optimization problem. The use of different penalizers in the functionals associated to the corresponding optimization problems has originated a variety other methods which can be considered as "variants" of the traditional Tikhonov-Phillips method of order zero. Such is the case for instance of the Tikhonov-Phillips method of order one, the total variation regularization method, etc. In this article we find sufficient conditions on the penalizers in generalized Tikhonov-Phillips functionals which guarantee existence and uniqueness and stability of the minimizers. The particular cases in which the penalizers are given by the bounded variation norm, by powers of seminorms and by linear combinations of powers of seminorms associated to closed operators, are studied. Several examples are presented and a few results on image restoration are shown.
Plummer, Sally; Tower, Clare; Alonso, Pedro; Morgan, Linda; Baker, Phil; Broughton-Pipkin, Fiona; Kalsheker, Noor
2004-07-01
Angiotensin II (AII) acts as a growth factor in local systems, mediating diverse effects such as cellular proliferation and apoptosis. These effects are controlled through two main receptor subtypes: AGTR1 and AGTR2. We studied the haplotype frequencies of both receptor genes in women with preeclamptic pregnancies and normotensive pregnant women. We also looked for any association between AGTR1 genotype at sites in the 5' flanking region and binding of AII to platelets, which express AGTR1, in 58 normotensive pregnant women. There were nine common haplotypes of AGTR1, with no significant difference in haplotype frequency between the two groups of women. Platelet AII binding in normotensive pregnant women was associated with the genotype at g.5245C>T in the 5' flanking region of AGTR1 (GenBank AF245699.1), with CC homozygotes at g.5245 having the lowest levels, and g.5245 TT homozygotes having the highest levels (P=0.05). Two novel polymorphisms were identified in AGTR2 (GenBank AY324607.1) at nucleotides g.1701T>C and g.2184A>T. Variation of AGTR2 could be explained by the existence of four common haplotypes. There was evidence for a significant increase in the frequency of the haplotype TAATGC at nucleotides g.1701, g.2041, g.2184, g.4673, g.4679, and g.4975, respectively (P=0.004), in women with preeclampsia. Copyright 2004 Wiley-Liss, Inc.
Expandable External Payload Carrier for Existing Launch Vehicles Project
National Aeronautics and Space Administration — Numerous existing launch vehicles have excess performance that is not being optimized. By taking advantage of excess, unused, performance, additional NASA...
Total-variation regularization with bound constraints
Chartrand, Rick [Los Alamos National Laboratory; Wohlberg, Brendt [Los Alamos National Laboratory
2009-01-01
We present a new algorithm for bound-constrained total-variation (TV) regularization that in comparison with its predecessors is simple, fast, and flexible. We use a splitting approach to decouple TV minimization from enforcing the constraints. Consequently, existing TV solvers can be employed with minimal alteration. This also makes the approach straightforward to generalize to any situation where TV can be applied. We consider deblurring of images with Gaussian or salt-and-pepper noise, as well as Abel inversion of radiographs with Poisson noise. We incorporate previous iterative reweighting algorithms to solve the TV portion.
The inverse variational problem in classical mechanics
Lopuszánski, Jan T
1999-01-01
This book provides a concise description of the current status of a fascinating scientific problem - the inverse variational problem in classical mechanics. The essence of this problem is as follows: one is given a set of equations of motion describing a certain classical mechanical system, and the question to be answered is: Do these equations of motion correspond to some Lagrange function as its Euler-Lagrange equations? In general, not for every system of equations of motion does a Lagrange function exist; it can, however, happen that one may modify the given equations of motion in such a w
Vacuum Potential and its Asymptotic Variation
Dahal, Pravin
2016-09-01
The possible form of existence of dark energy is explained and the relation for its asymptotic variation is given. This has two huge implications in the understanding of the Universe. The first is that the theory predicts that the Universe should be in negative pressure state in the very early period as required for inflation and spontaneous symmetry breaking. The second is that the theory gives the reasonable answer to the astrophysical evidence of dark energy dominating the Universe. The author is presenting his research in the nature of dark energy. Some of the work is submitted for publication in the journal and is currently under review.
Spatial Variations of Fundamental Constants
Barrow, John D; Barrow, John D.; Toole, Chris O'
1999-01-01
We show that observational limits on the possible time variation of constants of Nature are significantly affected by allowing for both space and time variation. Bekenstein's generalisation of Maxwell's equations to allow for cosmological variation of $alpha$ is investigated in a universe containing spherically symmetric inhomogeneities. The time variation of $alpha$ is determined by the local matter density and hence limits obtained in high-density geophysical enviroments are far more constraining than those obtained at high redshift. This new feature is expected to be a property of a wide class of theories for the variation of constants.
Variations on tremor parameters
Boose, A.; Jentgens, Ch.; Spieker, S.; Dichgans, J.
1995-03-01
This paper describes our analysis procedure for long-term tremor EMG recordings, as well as three examples of applications. The description of the method focuses on how characteristics of the tremor (e.g. frequency, intensity, agonist-antagonist interaction) can be defined and calculated based on surface EMG data. The resulting quantitative characteristics are called ``tremor parameters.'' We discuss sinusoidally modulated, band-limited white noise as a model for pathological tremor-EMG, and show how the basic parameters can be extracted from this class of signals. The method is then applied to (1) estimate tremor severity in clinical studies, (2) quantify agonist-antagonist interaction, and (3) investigate the variations of the tremor parameters using simple methods from time-series analysis.
Experimental evidence of the existence of a nonstationary coherent crystal state in bismuth
Misochko, O. V.
2014-02-01
The excitation of a bismuth (Bi) crystal by intense ultrashort laser pulses at liquid-helium temperature leads to consistent motion of atoms and variations in the electron density. At various time instants over an interval reaching several dosen picoseconds, atoms in the Bi lattice exhibit sequential pairing in the real and reciprocal spaces. This behavior may correspond to the formation of a coherent crystal—a special state of matter that combines the properties of a solid and quantum fluid. Experimental data showing evidence of the possible existence of this unusual state are presented and analyzed.
Delle Monache, M. L.; Goatin, P.
2014-12-01
We consider a strongly coupled PDE-ODE system that describes the influence of a slow and large vehicle on road traffic. The model consists of a scalar conservation law accounting for the main traffic evolution, while the trajectory of the slower vehicle is given by an ODE depending on the downstream traffic density. The moving constraint is expressed by an inequality on the flux, which models the bottleneck created in the road by the presence of the slower vehicle. We prove the existence of solutions to the Cauchy problem for initial data of bounded variation.
Denize Cristina Kaminski Ferreira
2011-12-01
Full Text Available The present article has as objective to analyze the relation between education and work throughout the history of the humanity, for in such a way, the starting point is the conceptualization of the related categories, as well as the exposition of its variations and relation in the different ways of material production of the existence human being (primitive community, slavery society, feudal system and capitalism, aiming at to apprehend the multiple influences that both exert between itself, in order to make possible a bigger understanding of the historical and social evolution of the man
Ioku, Norisuke, E-mail: ioku@ehime-u.ac.jp [Ehime University, Graduate School of Science Engineering (Japan); Ruf, Bernhard; Terraneo, Elide [Università degli Studi di Milano, Dipartimento di Matematica “F. Enriques” (Italy)
2015-12-15
We consider a semilinear heat equation with exponential nonlinearity in ℝ{sup 2}. We prove that local solutions do not exist for certain data in the Orlicz space exp L{sup 2}(ℝ{sup 2}), even though a small data global existence result holds in the same space exp L{sup 2}(ℝ{sup 2}). Moreover, some suitable subclass of exp L{sup 2}(ℝ{sup 2}) for local existence and uniqueness is proposed.
40 CFR 417.74 - Pretreatment standards for existing sources.
2010-07-01
...) EFFLUENT GUIDELINES AND STANDARDS SOAP AND DETERGENT MANUFACTURING POINT SOURCE CATEGORY Manufacture of Bar Soaps Subcategory § 417.74 Pretreatment standards for existing sources. Any existing source subject to this subpart that introduces process wastewater pollutants into a publicly owned treatment works must...
40 CFR 417.84 - Pretreatment standards for existing sources.
2010-07-01
...) EFFLUENT GUIDELINES AND STANDARDS SOAP AND DETERGENT MANUFACTURING POINT SOURCE CATEGORY Manufacture of Liquid Soaps Subcategory § 417.84 Pretreatment standards for existing sources. Any existing source... works must comply with 40 CFR part 403. In addition, the following pretreatment standard establishes the...
Existence of a Unique Zero of Nonlinear Systems
Bao, Paul; Anton, François; Rokne, Jon
2007-01-01
Existence statements for zeros of nonlinear equations are established via the interval Newton method generalizing previous theorems requiring regularity of the inclusion for the Jacobian.......Existence statements for zeros of nonlinear equations are established via the interval Newton method generalizing previous theorems requiring regularity of the inclusion for the Jacobian....
28 CFR 0.32 - Applicability of existing departmental regulations.
2010-07-01
... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Applicability of existing departmental regulations. 0.32 Section 0.32 Judicial Administration DEPARTMENT OF JUSTICE ORGANIZATION OF THE DEPARTMENT OF JUSTICE Community Relations Service § 0.32 Applicability of existing departmental...
AN EXISTENCE THEOREM FOR MAXIMAL ELEMENTS AND ITS APPLICATIONS
Hou Jicheng; He Wei
2007-01-01
An existence theorem of maximal elements for an L*-majorized correspondence de-fined on a non-paracompact H-space is established. As applications of the result, an equilibrium existence theorem for a non-paracompact generalized game in H-spaces with infinitely many players and with L*-majorized correspondences is given.
Existence and Uniqueness of Solution to ODEs: Lipschitz Continuity
Swarup Poria; Aman Dhiman
2017-05-01
The study of existence and uniqueness of solution of ordinarydifferential equation (ODE) became important due to the lack ofgeneral formula for solving nonlinear ODEs. In this article, weshall discuss briefly about the existence and uniqueness of solutionof a first order ODE. A special emphasis is given on theLipschitz continuous functions in the discussion.
Existence and bifurcation of integral manifolds with applications
HAN; Mao'an; CHEN; Xianfeng
2005-01-01
In this paper a bifurcation theorem on the existence of integral manifolds is obtained by using contracting principle. As an application, sufficient conditions for a higher dimensional system to have an integral manifold are given. Especially the existence and uniqueness of a 3-dimensional invariant torus appearing in a 4-dimensional autonomous system with singularity of codimension two are proved.
5 CFR 2412.4 - Existence of records requests.
2010-01-01
... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Existence of records requests. 2412.4 Section 2412.4 Administrative Personnel FEDERAL LABOR RELATIONS AUTHORITY, GENERAL COUNSEL OF THE FEDERAL... Existence of records requests. (a) An individual who desires to know if a system of records maintained...
A Dilemma That Underlies an Existence Proof in Geometry
Samper, Carmen; Perry, Patricia; Camargo, Leonor; Sáenz-Ludlow, Adalira; Molina, Óscar
2016-01-01
Proving an existence theorem is less intuitive than proving other theorems. This article presents a semiotic analysis of significant fragments of classroom meaning-making which took place during the class-session in which the existence of the midpoint of a line-segment was proven. The purpose of the analysis is twofold. First follow the evolution…
32 CFR 324.9 - Notification of record's existence.
2010-07-01
... 32 National Defense 2 2010-07-01 2010-07-01 false Notification of record's existence. 324.9 Section 324.9 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE... record's existence. All DFAS Privacy Act Officers shall establish procedures for notifying an...
Existence of solutions for a nonlinear degenerate elliptic system
Nguyen Minh
2004-07-01
Full Text Available In this paper, we study the existence of solutions for degenerate elliptic systems. We use the sub-super solution method, and the existence of classical and weak solutions. Some sub-supersolutions are constructed explicitly, when the nonlinearities have critical or supercritical growth.
Neural Network for Optimization of Existing Control Systems
Madsen, Per Printz
1995-01-01
The purpose of this paper is to develop methods to use Neural Network based Controllers (NNC) as an optimization tool for existing control systems.......The purpose of this paper is to develop methods to use Neural Network based Controllers (NNC) as an optimization tool for existing control systems....
The Existence Problem for Steiner Networks in Strictly Convex Domains
Freire, Alexandre
2011-05-01
We consider the existence problem for `Steiner networks' (trivalent graphs with 2 π/3 angles at each junction) in strictly convex domains, with `Neumann' boundary conditions. For each of the three possible combinatorial possibilities, sufficient conditions on the domain are derived for existence. In addition, in each case explicit examples of nonexistence are given.
The solution of location problems with certain existing facility structures
Juel, Henrik; Love, Robert F.
1983-01-01
It is known that in the Euclidean distance case, the optimal minisum location of a new facility in relation to four existing facilities is at the intersection of the two lines joining two pairs of the facilities. The authors extend this concept to minisum problems having any even number of existing...... facilities and characterized by generalized distance norms...
Developing Methodologies for Evaluating the Earthquake Safety of Existing Buildings.
Bresler, B.; And Others
This report contains four papers written during an investigation of methods for evaluating the safety of existing school buildings under Research Applied to National Needs (RANN) grants. In "Evaluation of Earthquake Safety of Existing Buildings," by B. Bresler, preliminary ideas on the evaluation of the earthquake safety of existing…
Safety assessment of existing highway bridges and viaducts
Maljaars, J.; Steenbergen, R.; Abspoel, L.; Kolstein, M.H.
2012-01-01
The assessment of the structural safety of existing br idges and viaducts becomes increasingly important in many countries owing to an increase in traffic loads. Most existing standards, however, are developed for the design of new structures. For this reason, an assessment method for determining th
A Method for Analyzing System Reliability of Existing Jacket Platforms
HE Yong; GONG Shun-feng; JIN Wei-liang
2008-01-01
Owing to the ageing of the existing structures worldwide and the lack of codes for the continued safety management of structures during their lifetime, it is very necessary to develop a tool to evaluate their system reliability over a time interval. In this paper, a method is proposed to analyze system reliability of existing jacket platforms. The influences of dint, crack and corrosion are considered. The mechanics characteristics of the existing jacket platforms to extreme loads are analyzed by use of the nonlinear mechanical analysis. The nonlinear interaction of pile-soil-structure is taken into consideration in the analysis. By use of FEM method and Monte Carlo simulation, the system reliability of the existing jacket platform can be obtained. The method has been illustrated through application to BZ28-1 three jacket platforms which have operated for sixteen years. Advantages of the proposed method for analyzing the system reliability of the existing jacket platform is also highlighted.
Kierkegaard e a existência possível
Roberto S. Kahlmeyer-Mertens
2013-05-01
Full Text Available Resumo: A relação entre a existência e a possibilidade, objeto deste artigo, merece especial atenção quando se trata de Kierkegaard. Isso porque, estes dois conceitos ocupam papéis primordiais na filosofia do autor, constituindo, justamente, o ponto a partir do qual o pensador se distancia criticamente da tradição filosófica. Caracterizar sumariamente os conceitos de existência e possibilidade na filosofia de Kierkegaard, bem como ambientar o filósofo em sua época como um pensador da existência, para além do rótulo de “existencialista”, são nossos presentes objetivos. Palavras-chave: Kierkegaard, filosofia da existência, existência, possibilidade
Existence of positive solutions to a Laplace equation with nonlinear boundary condition
Kim, C.-G.; Liang, Z.-P.; Shi, J.-P.
2015-12-01
The positive solutions of a Laplace equation with a superlinear nonlinear boundary condition on a bounded domain are studied. For higher-dimensional domains, it is shown that non-constant positive solutions bifurcate from a branch of trivial solutions at a sequence of bifurcation points, and under additional conditions on nonlinearity, the existence of a non-constant positive solution for any sufficiently large parameter value is proved by using variational approach. It is also proved that for one-dimensional domain, there is only one bifurcation point, all non-constant positive solutions lie on the bifurcating curve, and for large parameter values, there exist at least two non-constant positive solutions. For a special case, there are exactly two non-constant positive solutions.
On the existence of maximizing measures for irreducible countable Markov shifts: a dynamical proof
Bissacot, Rodrigo
2011-01-01
We prove that if $\\Sigma_{\\mathbf A}(\\mathbb N)$ is an irreducible Markov shift space over $\\mathbb N$ and $f:\\Sigma_{\\mathbf A}(\\mathbb N) \\rightarrow \\mathbb R$ is coercive with bounded variation then there exists a maxi-mizing probability measure for $f$, whose support lies on a Markov subshift over a finite alphabet. Furthermore, the support of any maximizing measure is contained in this same compact subshift. To the best of our knowledge, this is the first proof of the existence of maximizing measures beyond the finitely primitive case on the non-compact setting. It's also noteworthy that our technique works in the case of the full shift over positive real sequences.
On the existence of classical solutions for stationary extended mean field games
Gomes, Diogo A.
2014-04-01
In this paper we consider extended stationary mean-field games, that is mean-field games which depend on the velocity field of the players. We prove various a-priori estimates which generalize the results for quasi-variational mean-field games in Gomes et al. (2012). In addition we use adjoint method techniques to obtain higher regularity bounds. Then we establish the existence of smooth solutions under fairly general conditions by applying the continuity method. When applied to standard stationary mean-field games as in Lasry and Lions (2006), Gomes and Sanchez-Morgado (2011) or Gomes et al. (2012) this paper yields various new estimates and regularity properties not available previously. We discuss additionally several examples where the existence of classical solutions can be proved. © 2013 Elsevier Ltd. All rights reserved.
Existence of solutions to fractional boundary-value problems with a parameter
Ya-Ning Li
2013-06-01
Full Text Available This article concerns the existence of solutions to the fractional boundary-value problem $$displaylines{ -frac{d}{dt} ig(frac{1}{2} {}_0D_t^{-eta}+ frac{1}{2}{}_tD_{T}^{-eta}igu'(t=lambda u(t+abla F(t,u(t,quad hbox{a.e. } tin[0,T], cr u(0=0,quad u(T=0. }$$ First for the eigenvalue problem associated with it, we prove that there is a sequence of positive and increasing real eigenvalues; a characterization of the first eigenvalue is also given. Then under different assumptions on the nonlinearity F(t,u, we show the existence of weak solutions of the problem when $lambda$ lies in various intervals. Our main tools are variational methods and critical point theorems.
Geometric constrained variational calculus. II: The second variation (Part I)
Massa, Enrico; Bruno, Danilo; Luria, Gianvittorio; Pagani, Enrico
2016-10-01
Within the geometrical framework developed in [Geometric constrained variational calculus. I: Piecewise smooth extremals, Int. J. Geom. Methods Mod. Phys. 12 (2015) 1550061], the problem of minimality for constrained calculus of variations is analyzed among the class of differentiable curves. A fully covariant representation of the second variation of the action functional, based on a suitable gauge transformation of the Lagrangian, is explicitly worked out. Both necessary and sufficient conditions for minimality are proved, and reinterpreted in terms of Jacobi fields.
Cordier, S.
1995-05-01
In this work a 1-D model of electrons and ions plasma is considered. Electrons are supposed to be in Maxwell-Boltzmann thermodynamic equilibrium while ions are described with an isothermal flow model of charged particles submitted to a self-consistent electric field. A collision term between neutral particles and ions simulates the presence of neutral particles. This work demonstrates the existence of low entropy solutions for this simple model with arbitrary initial conditions. Most of the paper is devoted to the demonstration of this theorem and follows the successive steps: construction of a numerical scheme, recall of the classical properties of Riemann problem solutions using Glimm method, uniform estimations for the whole variation norm, and finally, convergence of the constructed solutions towards a low entropy solution for the non-linear Euler/Poisson system. Domains of application for this type of model are listed in the conclusion. (J.S.). 18 refs.
Partition Equilibrium Always Exists in Resource Selection Games
Anshelevich, Elliot; Caskurlu, Bugra; Hate, Ameya
We consider the existence of Partition Equilibrium in Resource Selection Games. Super-strong equilibrium, where no subset of players has an incentive to change their strategies collectively, does not always exist in such games. We show, however, that partition equilibrium (introduced in [4] to model coalitions arising in a social context) always exists in general resource selection games, as well as how to compute it efficiently. In a partition equilibrium, the set of players has a fixed partition into coalitions, and the only deviations considered are by coalitions that are sets in this partition. Our algorithm to compute a partition equilibrium in any resource selection game (i.e., load balancing game) settles the open question from [4] about existence of partition equilibrium in general resource selection games. Moreover, we show how to always find a partition equilibrium which is also a Nash equilibrium. This implies that in resource selection games, we do not need to sacrifice the stability of individual players when forming solutions stable against coalitional deviations. In addition, while super-strong equilibrium may not exist in resource selection games, we show that its existence can be decided efficiently, and how to find one if it exists.
O. Gorgulu
2015-02-01
Full Text Available Converting existing Reinforced Concrete (RC frames into RC infill walls is one of the most efficient seismic strengthening technique due to its simplicity in application providing high rigidity, stability and strength in structures. On the other hand, this method affects the seismic behavior of existing RC structure in terms of the energy dissipation capacity or in other words, ductility reduction factor, Rμ. This research is an attempt to investigate the RC infill wall ratio effect on ductility reduction factor in terms of the seismic rehabilitation of the typical RC school buildings. For this purpose, nonlinear static pushover analyses are conducted for existing 3 and 5 story RC school buildings which were rehabilitated with different RC infill wall ratio. Numerical analyses are carried out by using the fiber element based modeling approach in the software, Perform-3D. Based on these analytical results, correlation between the ductility reduction factor and the RC infill wall ratio is obtained for the seismic rehabilitation of the RC school buildings. In addition, two mathematical expressions for the variation of the ductility reduction factor with RC infill wall ratios are proposed in terms of the preliminary seismic rehabilitation assessment of the existing RC school buildings.
Variational approach to various nonlinear problems in geometry and physics
2008-01-01
In this survey, we will summarize the existence results of nonlinear partial differential equations which arises from geometry or physics by using variational method. We use the method to study Kazdan-Warner problem, Chern-Simons-Higgs model, Toda systems, and the prescribed Q-curvature problem in 4-dimension.
Organizational Training across Cultures: Variations in Practices and Attitudes
Hassi, Abderrahman; Storti, Giovanna
2011-01-01
Purpose: The purpose of this paper is to provide a synthesis based on a review of the existing literature with respect to the variations in training practices and attitudes across national cultures. Design/methodology/approach: A content analysis technique was adopted with a comparative cross-cultural management perspective as a backdrop to…
Variational multi-valued velocity field estimation for transparent sequences
Ramirez-Manzanares, Alonso; Rivera, Mariano; Kornprobst, Pierre;
2011-01-01
Motion estimation in sequences with transparencies is an important problem in robotics and medical imaging applications. In this work we propose a variational approach for estimating multi-valued velocity fields in transparent sequences. Starting from existing local motion estimators, we derive a...
Morphological variation of Nile tilapia populations from major water ...
ACSS
1Aquaculture Research and Development Center, Kajjansi, Box 530, ... important to establish the existing strains in a manner that is phenotypically discernible where ... morphological variation among the different populations of Nile tilapia and the fish could be grouped ..... Evolutionary history of Nile perch Lates sp. inferred.
Biometric variation in Spadella cephaloptera on the Canary Islands (Chaetognatha)
Broerse, Alexandra T.C.
1993-01-01
Specimens of Spadella cephaloptera from Tenerife, Gran Canaria and Gomera (Canary Islands) were compared biometrically in regards to morphometric and meristic characters. Variation exists among the populations on the islands as well as between the islands. The populations on Gomera seem more distinc
Towards Modelling Variation in Music as Foundation for Similarity
Volk, A.; de Haas, W.B.; van Kranenburg, P.; Cambouropoulos, E.; Tsougras, C.; Mavromatis, P.; Pastiadis, K.
2012-01-01
This paper investigates the concept of variation in music from the perspective of music similarity. Music similarity is a central concept in Music Information Retrieval (MIR), however there exists no comprehensive approach to music similarity yet. As a consequence, MIR faces the challenge on how to
A Framework for Describing Variations in State Early Intervention Systems.
Spiker, Donna; Hebbeler, Kathleen; Wagner, Mary; Cameto, Renee; McKenna, Patti
2000-01-01
Information about the early intervention service systems in 20 states was gathered and organized into dimensions of a framework for describing early intervention systems at the state and local levels. Results indicate considerable variation exists on eligibility criteria, agencies involved in early intervention, and models of intake and service…
Sun Fuqin; Wang Mingxin
2004-01-01
In this paper, we study the non-negative solutions to a degenerate parabolic system with nonlinear boundary conditions in the multi-dimensional case.By the upper and lower solutions method, we give the conditions on the existence and non-existence of global solutions.
Mothers depart. Variations 2009
Agnieszka Czyżak
2011-01-01
Full Text Available This article proposes some considerations on a particular variation of the elegiac mood represented by and manifested in lyrical farewells of departing mothers. A review of the variants commences with an analysis of a particularly important work by Tadeusz Różewicz written at the beginning of this century — Matka odchodzi. The book was, at the time, a particular reference point for the following poetic volumes in which the theme of the death of the poet’s mother was paramount and significant. The article also focuses on volumes of poems, written by poets that belonged to different generations but shared the same date of publication, i.e. the year 2009. Both clear similarities and marked differences in the actual commitment in carrying out the theme and in creating the profiles of mothers that have passed away are to be found in the works of Piotr Sommer (Dni i noce, Jan Polkowski (Cantus and Eugeniusz Tkaczyszyn-Dycki (Piosenka o zależnościach i uzależnieniach.
Criteria for Existence of Surface Plasmon Polaritons at Lossy Interfaces
Sang-Nourpour, Nafiseh; Kheradmand, R; Rezaei, M; Sanders, Barry C
2016-01-01
We determine bounds for the square of the complex propagation coefficient for fields at planar lossy interfaces, and we employ these bounds to determine rigorous criteria for electromagnetic susceptibilities that lead to existence of surface plasmon polaritons. Ascertaining existence or nonexistence of surface plasmon polaritons is important to check the viability of a given study or application. As an application we show that surface plasmon polaritons cannot exist for double-negative refractive index region with arbitrary values of permittivity and permeability and we employ our criteria to show that certain prior predictions of surface plasmon polaritons are not in fact correct.
Environmental impacts of increased hydroelectric development at existing dams
Railsback, S. F. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Cada, G. F. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Petrich, C. H. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Sale, M. J. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Shaakir-Ali, J. A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Watts, J. A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Webb, J. W. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
1991-04-01
This report describes the environmental impacts of a proposed U.S. Department of Energy (DOE) initiative to promote the development of hydropower resources at existing dams. Hydropower development at existing dams has, in general, fewer impacts than development of additional fossil-fueled resources or hydropower at new dams, although potential cumulative impacts of developing multiple hydropower projects have not been explicitly addressed. Environmental review of project impacts and mitigation needs can ensure that additional hydropower development at existing dams can provide a renewable resource with fewer impacts than alternative resources.
A coupled chemotaxis-fluid model: Global existence
Liu, Jian-Guo
2011-09-01
We consider a model arising from biology, consisting of chemotaxis equations coupled to viscous incompressible fluid equations through transport and external forcing. Global existence of solutions to the Cauchy problem is investigated under certain conditions. Precisely, for the chemotaxis-Navier- Stokes system in two space dimensions, we obtain global existence for large data. In three space dimensions, we prove global existence of weak solutions for the chemotaxis-Stokes system with nonlinear diffusion for the cell density.© 2011 Elsevier Masson SAS. All rights reserved.
EXISTENCE OF 0-1 UNIVERSAL MINIMAL TOTAL DOMINATING FUNCTIONS
FANG Qizhi
2004-01-01
In this paper, we study the existence of 0-1 universal minimal total dominating functions in a graph. We establish a formulation of linear inequalities to characterize universal minimal total dominating functions and show that for a kind of graphs whose adjacent matrices are balanced, the existence of universal minimal total dominating functions coincides with that of 0-1 ones. It is also proved that for general graphs, the problem of testing the existence of 0-1 universal minimal total dominating functions is NP-hard.
Sidereal variations deep underground in Tasmania
Humble, J. E.; Fenton, A. G.; Fenton, K. B.
1985-01-01
Data from the deep underground vertically directed muon telescopes at Poatina, Tasmania, have been used since 1972 for a number of investigations, including the daily intensity variations, atmospheric influences, and checking for possible effects due to the interplanetary magnetic field. These telescopes have a total sensitive area of only 3 square meters, with the result that the counting rate is low (about 1680 events per hour) and the statistical errors on the results are rather large. Consequently, it was decided several years ago to construct larger detectors for this station. The first of these telescopes has been in operation for two complete years, and the results from it are presented. Results from the new, more stable equipment at Poatina appear to confirm the existence of a first harmonic in the daily variations in sidereal time reported earlier, and are consistent with small or non-existent first harmonics in solar and anti-sidereal time. All the second harmonics appear to be small, if not zero at these energies.
Spectral-collocation variational integrators
Li, Yiqun; Wu, Boying; Leok, Melvin
2017-03-01
Spectral methods are a popular choice for constructing numerical approximations for smooth problems, as they can achieve geometric rates of convergence and have a relatively small memory footprint. In this paper, we introduce a general framework to convert a spectral-collocation method into a shooting-based variational integrator for Hamiltonian systems. We also compare the proposed spectral-collocation variational integrators to spectral-collocation methods and Galerkin spectral variational integrators in terms of their ability to reproduce accurate trajectories in configuration and phase space, their ability to conserve momentum and energy, as well as the relative computational efficiency of these methods when applied to some classical Hamiltonian systems. In particular, we note that spectrally-accurate variational integrators, such as the Galerkin spectral variational integrators and the spectral-collocation variational integrators, combine the computational efficiency of spectral methods together with the geometric structure-preserving and long-time structural stability properties of symplectic integrators.
Demography and ecology drive variation in cooperation across human populations.
Lamba, Shakti; Mace, Ruth
2011-08-30
Recent studies argue that cross-cultural variation in human cooperation supports cultural group selection models of the evolution of large-scale cooperation. However, these studies confound cultural and environmental differences between populations by predominantly sampling one population per society. Here, we test the hypothesis that behavioral variation between populations is driven by environmental differences in demography and ecology. We use a public goods game played with money and a naturalistic measure of behavior involving the distribution of salt, an essential and locally valued resource, to demonstrate significant variation in levels of cooperation across 16 discrete populations of the same small-scale society, the Pahari Korwa of central India. Variation between these populations of the same cultural group is comparable to that found between different cultural groups in previous studies. Demographic factors partly explain this variation; age and a measure of social network size are associated with contributions in the public goods game, while population size and the number of adult sisters residing in the population are associated with decisions regarding salt. That behavioral variation is at least partly contingent on environmental differences between populations questions the existence of stable norms of cooperation. Hence, our findings call for reinterpretation of cross-cultural data on cooperation. Although cultural group selection could theoretically explain the evolution of large-scale cooperation, our results make clear that existing cross-cultural data cannot be taken as empirical support for this hypothesis.
Robust design principles for reducing variation in functional performance
Christensen, Martin Ebro; Howard, Thomas J.
2016-01-01
This paper identifies, describes and classifies a comprehensive collection of variation reduction principles (VRP) that can be used to increase the robustness of a product and reduce its variation in functional performance. Performance variation has a negative effect on the reliability and percei......This paper identifies, describes and classifies a comprehensive collection of variation reduction principles (VRP) that can be used to increase the robustness of a product and reduce its variation in functional performance. Performance variation has a negative effect on the reliability...... and perceived quality of a product and efforts should be made to minimise it. The design principles are identified by a systematic decomposition of the Taguchi Transfer Function in combination with the use of existing literature and the authors’ experience. The paper presents 15 principles and describes...... their advantages and disadvantages along with example cases. Subsequently, the principles are classified based on their applicability in the various development and production stages. The VRP are to be added to existing robust design methodologies, helping the designer to think beyond robust design tool and method...
Robust design principles for reducing variation in functional performance
Christensen, Martin Ebro; Howard, Thomas J.
2016-01-01
This paper identifies, describes and classifies a comprehensive collection of variation reduction principles (VRP) that can be used to increase the robustness of a product and reduce its variation in functional performance. Performance variation has a negative effect on the reliability and percei......This paper identifies, describes and classifies a comprehensive collection of variation reduction principles (VRP) that can be used to increase the robustness of a product and reduce its variation in functional performance. Performance variation has a negative effect on the reliability...... and perceived quality of a product and efforts should be made to minimise it. The design principles are identified by a systematic decomposition of the Taguchi Transfer Function in combination with the use of existing literature and the authors’ experience. The paper presents 15 principles and describes...... their advantages and disadvantages along with example cases. Subsequently, the principles are classified based on their applicability in the various development and production stages. The VRP are to be added to existing robust design methodologies, helping the designer to think beyond robust design tool and method...
The Split Variational Inequality Problem
Censor, Yair; Reich, Simeon
2010-01-01
We propose a new variational problem which we call the Split Variational Inequality Problem (SVIP). It entails finding a solution of one Variational Inequality Problem (VIP), the image of which under a given bounded linear transformation is a solution of another VIP. We construct iterative algorithms that solve such problems, under reasonable conditions, in Hilbert space and then discuss special cases, some of which are new even in Euclidean space.
Diurnal variation of mountain waves
R. M. Worthington
2006-11-01
Full Text Available Mountain waves could be modified as the boundary layer varies between stable and convective. However case studies show mountain waves day and night, and above e.g. convective rolls with precipitation lines over mountains. VHF radar measurements of vertical wind (1990–2006 confirm a seasonal variation of mountain-wave amplitude, yet there is little diurnal variation of amplitude. Mountain-wave azimuth shows possible diurnal variation compared to wind rotation across the boundary layer.
Ground Vehicle Navigation Using Magnetic Field Variation
Shockley, Jeremiah A.
The Earth's magnetic field has been the bedrock of navigation for centuries. The latest research highlights the uniqueness of magnetic field measurements based on position due to large scale variations as well as localized perturbations. These observable changes in the Earth's magnetic field as a function of position provide distinct information which can be used for navigation. This dissertation describes ground vehicle navigation exploiting variation in Earth's magnetic field using a self-contained navigation system consisting of only a magnetometer and magnetic field maps. In order to achieve navigation, effective calibration enables repeatable magnetic field measurements from different vehicles and facilitates mapping of the observable magnetic field as a function of position. A new modified ellipsoid calibration technique for strapdown magnetometers in large vehicles is described, as well as analysis of position measurement generation comparing a multitude of measurement compositions using existing and newly developed likelihood techniques. Finally, navigation solutions are presented using both a position measurement and direct incorporation of the magnetometer measurements via a particle filter to demonstrate road navigation in three different environments. Emphatically, the results affirm that navigation using magnetic field variation in ground vehicles is viable and achieves adequate performance for road level navigation.
78 FR 15743 - Proposed Extension of Existing Collection; Comment Request
2013-03-12
... to the Division of Coal Mine Workers' Compensation (DCMWC) each policy and endorsement issued... of Workers' Compensation Programs Proposed Extension of Existing Collection; Comment Request ACTION... respondents can be properly assessed. Currently, the Office of Workers' Compensation Programs is...
Report on the Pre-existing Condition Insurance Plan Program
U.S. Department of Health & Human Services — Before the Affordable Care Act, Americans with pre-existing conditions who did not receive health coverage through their employers had few affordable options to get...
Existence for a class of discrete hyperbolic problems
Luca Rodica
2006-01-01
Full Text Available We investigate the existence and uniqueness of solutions to a class of discrete hyperbolic systems with some nonlinear extreme conditions and initial data, in a real Hilbert space.
Uniqueness and existence results for ordinary differential equations
Cid, J. Angel; Heikkila, Seppo; Pouso, Rodrigo Lopez
2006-04-01
We establish some uniqueness and existence results for first-order ordinary differential equations with constant-signed discontinuous nonlinear parts. Several examples are given to illustrate the applicability of our work.
Local Existence of Smooth Solutions to the FENE Dumbbell Model
Ge YANG
2012-01-01
The author proves the local existence of smooth solutions to the finite extensible nonlinear elasticity (FENE) dumbbell model of polymeric flows in some weighted spaces if the non-dimensional parameter b ＞ 2.
Monthly Pre-Existing Condition Insurance Plan Enrollment
U.S. Department of Health & Human Services — The Affordable Care Act created the new Pre-Existing Condition Insurance Plan (PCIP) program to make health insurance available to Americans denied coverage by...
Facilities Improvement for Sustainability of Existing Public Office ...
Sultan
2Faculty of Technology Management and Business, Universiti Tun Hussein Onn ... The features were classified into Spatial Plan, Structure and Facilities, ..... audio and emergency buttons that call into the ..... Existing School Buildings: A Case.
A scientist finally proves existence of elusive axion
2006-01-01
"Using a visual target/detector, a University of Buffalo researcher has revealed the existence of the axion, a tiny particle with no charge, a very low mass and a lifetime much shorter than a nanosecond." (1,5 page)
77 FR 6823 - Proposed Extension of Existing Collection; Comment Request
2012-02-09
...: Extension. Agency: Office of Workers' Compensation Programs. Title: Statement of Recovery Forms. OMB Number... of Workers' Compensation Programs Proposed Extension of Existing Collection; Comment Request ACTION... respondents can be properly assessed. Currently, the Office of Workers' Compensation Programs is...
77 FR 40645 - Proposed Extension of Existing Collection; Comment Request
2012-07-10
...: Office of Workers' Compensation Programs. Title: Overpayment Recovery Questionnaire. ] OMB Number: 1240... of Workers' Compensation Programs Proposed Extension of Existing Collection; Comment Request ACTION... respondents can be properly assessed. Currently, the Office of Workers' Compensation Programs is...
Problem of mathematical deduction of the existence of black holes
Yuan-Shun Chin
1990-01-01
Full Text Available The mathematical proof of existence of Black Hole is based on the assumption of mass being independent of speed. Considering the effect of special relativity of the dependence of mass with speed there is no Black hole.
EXISTENCE OF POSITIVE SOLUTION TO A p-LAPLACIAN SYSTEM
无
2009-01-01
A p-Laplacian system with Dirichlet boundary conditions is investigated. By the fibering method introduced by Pohozaev,we discuss the existence of positive weak solutions to the system under some proper conditions.
On the existence of high index topologically minimal surfaces
Bachman, David
2009-01-01
The topological index of a surface was previously introduced by the first author as the topological analogue of the index of an unstable minimal surface. Here we show that surfaces of arbitrarily high topological index exist.
EXISTENCE OF GENERALIZED WEAKLYSOLUTIONS OF DIFFERENTIAL EQUATIONS IN PRODUCT SPACES
范进军
2004-01-01
In this paper, by using Lyapunov function and weak noncompactness conditions, we give an existence theorem of generalized weakly solutions of Cauchy problem of differential equations in product spaces.
Contesting the existence of male speech stereotypes within the ...
Contesting the existence of male speech stereotypes within the communicative context of nursing: a case of Bonda mission ... speech stereotypes to the communicative context of nursing. ... EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT
A Comparison of Existing Optimisation Techniques with the ...
... Existing Optimisation Techniques with the Univariate Marginal Distribution Algorithm ... graph colouring, neural networks, genetic algorithms and tabu search. ... optimization techniques and we show how the proposed algorithm performs in ...
Existence and Uniqueness of Solutions to Random Impulsive Differential Systems
Shu-jin Wu; Xiao-lin Guo; Song-qing Lin
2006-01-01
The existence and uniqueness in mean square of solutions to certain random impulsive differential systems is discussed in this paper. Cauchy-Schwarz inequality, Lipschtiz condition and techniques in stochastic analysis are employed in achieve the desired results.
Existence of solutions to fractional Hamiltonian systems with combined nonlinearities
Ziheng Zhang
2016-01-01
Full Text Available This article concerns the existence of solutions for the fractional Hamiltonian system $$\\displaylines{ - _tD^{\\alpha}_{\\infty}\\big(_{-\\infty}D^{\\alpha}_{t}u(t\\big -L(tu(t+\
Existence of solutions for elliptic systems with critical Sobolev exponent
Pablo Amster
2002-06-01
Full Text Available We establish conditions for existence and for nonexistence of nontrivial solutions to an elliptic system of partial differential equations. This system is of gradient type and has a nonlinearity with critical growth.
The existence of policies, practices and perceptions regarding ...
Interviews were conducted with 7 nursing managers regarding the existence and content of a hospital visitors' policy, 12 oper- .... but only by people >12 years of age in .... doctor felt children should only be allowed to visit the terminally ill.
Existence of Weak Solutions for a Nonlinear Elliptic System
Gilbert RobertP
2009-01-01
Full Text Available We investigate the existence of weak solutions to the following Dirichlet boundary value problem, which occurs when modeling an injection molding process with a partial slip condition on the boundary. We have in ; in ; , and on .
An existence theorem for Volterra integrodifferential equations with infinite delay
Ferenc Izsak
2003-01-01
Full Text Available Using Schauder's fixed point theorem, we prove an existence theorem for Volterra integrodifferential equations with infinite delay. As an appplication, we consider an $n$ species Lotka-Volterra competitive system.
Stability and Existence of Multidimensional Subsonic Phase Transitions
Ya-Guang Wang; Zhouping Xin
2003-01-01
The purpose of this paper is to prove the uniform stability of multidimensional subsonic phase transitions satisfying the viscosity-capillarity criterion in a van der Waals fluid, and further to establish the local existence of phase transition solutions.
design analysis of an existing acha (digitaria exilis) dehulling machine
PUBLICATIONS1
The performance of the existing dehulling machine was first evaluated to determine the required modification. Im- ... cation of a high movement and flow of proper- ... This was carried out at the ..... basic load rating or dynamic carrying capacity.
Possible existence of wormholes in the central regions of halos
Rahaman, Farook, E-mail: rahaman@iucaa.ernet.in [Department of Mathematics, Jadavpur University, Kolkata 700032, West Bengal (India); Salucci, P., E-mail: salucci@sissa.it [SISSA, International School for Advanced Studies, Via Bonomea 265, 34136, Trieste (Italy); INFN, Sezione di Trieste, Via Valerio 2, 34127, Trieste (Italy); Kuhfittig, P.K.F., E-mail: kuhfitti@msoe.edu [Department of Mathematics, Milwaukee School of Engineering, Milwaukee, WI 53202-3109 (United States); Ray, Saibal, E-mail: saibal@iucaa.ernet.in [Department of Physics, Government College of Engineering and Ceramic Technology, Kolkata 700010, West Bengal (India); Rahaman, Mosiur, E-mail: mosiurju@gmail.com [Department of Mathematics, Meghnad Saha Institute of Technology, Kolkata 700150 (India)
2014-11-15
An earlier study (Rahaman, et al., 2014 and Kuhfittig, 2014) has demonstrated the possible existence of wormholes in the outer regions of the galactic halo, based on the Navarro–Frenk–White (NFW) density profile. This paper uses the Universal Rotation Curve (URC) dark matter model to obtain analogous results for the central parts of the halo. This result is an important compliment to the earlier result, thereby confirming the possible existence of wormholes in most of the spiral galaxies. - Highlights: • Earlier we showed possible existence of wormholes in the outer regions of halo. • We obtain here analogous results for the central parts of the galactic halo. • Our result is an important compliment to the earlier result. • This confirms possible existence of wormholes in most of the spiral galaxies.
Existence of Solution for Fractional Differential Problem with a Parameter
Shi Ai-ling; Zhang Shu-qin
2014-01-01
We apply the method of lower and upper solutions combined with mono-tone iterations to fractional differential problem with a parameter. The existence of minimal and maximal solutions is proved for the fractional differential problem with a parameter.
Branding in children: a barbaric practice still exists in India.
Patra, Pratap Kumar
2016-01-01
Branding is an inhuman traditional practice most commonly employed to treat various disorders in neonates and children in certain community in India. Though stringent law exists to prevent such harmful practices, cases of branding is not uncommon in current era.
Explorations in Regional Variation: A Variational Pragmatic Perspective
Barron, Anne
2015-01-01
The present article introduces the Special Issue entitled "A Variational Pragmatic Approach to Regional Variation in Language," a collection of papers which celebrates the work of Klaus P. Schneider (Rheinische Friedrich-Wilhelms-Universität Bonn, Germany) on the occasion of his 60th birthday.
The theorem on existence of singular solutions to nonlinear equations
Prusinska А.
2005-01-01
Full Text Available The aim of this paper is to present some applications of pregularity theory to investigations of nonlinear multivalued mappings. The main result addresses to the problem of existence of solutions to nonlinear equations in the degenerate case when the linear part is singular at the considered initial point. We formulate conditions for existence of solutions of equation F(x = 0 when first p - 1 derivatives of F are singular.
How Do We Know Protons, Electrons, and Quarks Really Exist?
Robertson, Bill
2005-01-01
Scientific explanations often make use of things that cannot be seen or felt, such as protons, electrons, and quarks. Do these things really exist? If so, how do is it known that they exist? Imagine being enclosed in a completely dark room with no light at all and not being able to see a thing. Being chained to a chair somewhere in the room, and…
Existence of a principal eigenvalue for the Tricomi problem
Daniela Lupo
2000-10-01
Full Text Available The existence of a principal eigenvalue is established for the Tricomi problem in normal domains; that is, the existence of a positive eigenvalue of minimum modulus with an associated positive eigenfunction. The argument here uses prior results of the authors on the generalized solvability in weighted Sobolev spaces and associated maximum/minimum principles cite{[LP2]} coupled with known results of Krein-Rutman type.
New Challenge to the Existing Fuelling Technique for ITER
DENGBaiquan; PENGLilin
2003-01-01
A new challenge to the existing pellet fuelling technique for the International Thermonuclear Experimental Reactor (ITER) has been discussed by computing ablation rate using Kuteev lentil model with considering the kinetic effects. Numerical integral results show the existing pellet injection technique will be difficult to meet the deep fuelling requirement for the reactor relevant plasma of ITER. As high as a pressure of 254 MPa should be applied to the pellet accelerator of 2-meters long single stage pneumatic gun,
Existence of solitary waves in dipolar quantum gases
Antonelli, Paolo
2011-02-01
We study a nonlinear Schrdinger equation arising in the mean field description of dipolar quantum gases. Under the assumption of sufficiently strong dipolar interactions, the existence of standing waves, and hence solitons, is proved together with some of their properties. This gives a rigorous argument for the possible existence of solitary waves in BoseEinstein condensates, which originate solely due to the dipolar interaction between the particles. © 2010 Elsevier B.V. All rights reserved.
Existence of solutions to quasilinear Schrodinger equations with indefinite potential
Zupei Shen
2015-04-01
Full Text Available In this article, we study the existence and multiplicity of solutions of the quasilinear Schrodinger equation $$ -u''+V(xu-(|u| ^2''u=f(u $$ on $\\mathbb{R}$, where the potential $V$ allows sign changing and the nonlinearity satisfies conditions weaker than the classical Ambrosetti-Rabinowitz condition. By a local linking theorem and the fountain theorem, we obtain the existence and multiplicity of solutions for the equation.
The Existence of Homoclinic Solutions for Second Order Hamiltonian System
Jie Gao
2011-10-01
Full Text Available The research of homoclinic orbits for Hamiltonian system is a classical problem, it has valuable applications in celestial mechanics, plasma physis, and biological engineering. For example, homoclinic orbits rupture can yield chaos lead to more complex dynamics behaviour. This paper studies the existence of homoclinic solutions for a class of second order Hamiltonian system, we will prove this system exists at least one nontrivial homoclinic solution.
Existence and properties of the Navier-Stokes equations
Zhirkin, Alexey V.
2016-01-01
A proof of existence, uniqueness and smoothness of the Navier-Stokes equations is an actual problem, which solution is important for different branches of science. The subject of this study is obtaining the smooth and unique solutions of the three-dimension Stokes-Navier equations for the initial and boundary value problem. The analysis shows that there exist no viscous solutions of the Navier-Stokes equations in three dimensions. The reason is the insufficient capability of the divergence-fr...
Newspaper and internet display advertising - co-existence or substitution?
Lindstädt, Nadine; Budzinski, Oliver
2012-01-01
Newspapers have been experiencing declining circulation figures and diminishing advertising revenues for several years – both effects might pose a threat to the continuing existence of (print) newspapers. In an earlier paper, Lindstädt & Budzinski (2011) argued from a theoretical viewpoint that industry-specific patterns exist that determine substitution or complementation effects between internet and newspaper advertising. It was argued that retail advertising, in particular, may offer a nic...
Existence and Uniqueness of Fixed Point in Partially Ordered Sets
Juan J. NIETO; Rosana RODR(I)GUEZ-L(O)PEZ
2007-01-01
We prove some fixed point theorems in partially ordered sets, providing an extension of theBanach contractive mapping theorem. Having studied previously the nondecreasing case, we considerin this paper nonincreasing mappings as well as non monotone mappings. We also present someapplications to first-order ordinary differential equations with periodic boundary conditions, provingthe existence of a unique solution admitting the existence of a lower solution.
On the existence and multiplicity of extensions in dialectical argumentation
2002-01-01
In the present paper, the existence and multiplicity problems of extensions are addressed. The focus is on extension of the stable type. The main result of the paper is an elegant characterization of the existence and multiplicity of extensions in terms of the notion of dialectical justification, a close cousin of the notion of admissibility. The characterization is given in the context of the particular logic for dialectical argumentation DEFLOG. The results are of direct relevance for sever...
Existence of Traveling Waves for the Generalized F-KPP Equation.
Kollár, Richard; Novak, Sebastian
2017-03-01
Variation in genotypes may be responsible for differences in dispersal rates, directional biases, and growth rates of individuals. These traits may favor certain genotypes and enhance their spatiotemporal spreading into areas occupied by the less advantageous genotypes. We study how these factors influence the speed of spreading in the case of two competing genotypes under the assumption that spatial variation of the total population is small compared to the spatial variation of the frequencies of the genotypes in the population. In that case, the dynamics of the frequency of one of the genotypes is approximately described by a generalized Fisher-Kolmogorov-Petrovskii-Piskunov (F-KPP) equation. This generalized F-KPP equation with (nonlinear) frequency-dependent diffusion and advection terms admits traveling wave solutions that characterize the invasion of the dominant genotype. Our existence results generalize the classical theory for traveling waves for the F-KPP with constant coefficients. Moreover, in the particular case of the quadratic (monostable) nonlinear growth-decay rate in the generalized F-KPP we study in detail the influence of the variance in diffusion and mean displacement rates of the two genotypes on the minimal wave propagation speed.
Variational principles of second, first and intermediate kinds for non-holonomic mechanics
朱如曾
1999-01-01
The differential variational principles of second kind for non-holonomic mechanics are given, from which a number of integral variational principles of second kind are set up. From the latter, the general relation of δq’-δq and the general form of integral variational principles of the first kind and intermediate kinds are derived. Thus not only all previous relations of δq-δq and integral variational principles are unified but also the existance of the variational principles of intermediate kinds are pointed out.
Vankan, Emy; Schoorel, Ellen N. C.; van Kuijk, Sander M. J.; Mol, Ben-Willem J.; Nijhuis, Jan G.; Aardenburg, Robert; Alink, Marleen; de Boer, Karin; Delemarre, Friso M. C.; Dirksen, Carmen D.; Van Dooren, Ivo M. A.; Franssen, Maureen T. M.; Kaplan, Mesrure; Kleiverda, Gunilla; Kuppens, Simone M. I.; Kwee, Anneke; Langenveld, Josje; Lim, Frans T. H.; Melman, Sonja; Sikkema, Marko J.; Smits, Luc J.; Visser, Harry; Woiski, Mallory; Scheepers, Hubertina C.; Hermens, Rosella P. M. G.
IntroductionLarge practice variation exists in mode of delivery after cesarean section, suggesting variation in implementation of contemporary guidelines. We aim to evaluate this practice variation and to what extent this can be explained by risk factors at patient level. Material and methodsThis
Vankan, E.; Schoorel, E.N.; Kuijk, S.M. van; Mol, B.J.; Nijhuis, J.G.; Aardenburg, R.; Alink, M.; Boer, K. de; Delemarre, F.M.; Dirksen, C.D.; Dooren, I.M. van; Franssen, M.T.; Kaplan, M.; Kleiverda, G.; Kuppens, S.M.; Kwee, A.; Langenveld, J.; Lim, F.T.; Melman, S.; Sikkema, M.J.; Smits, L.J; Visser, H.; Woiski, M.D.; Scheepers, H.C.; Hermens, R.P.M.G.
2017-01-01
INTRODUCTION: Large practice variation exists in mode of delivery after cesarean section, suggesting variation in implementation of contemporary guidelines. We aim to evaluate this practice variation and to what extent this can be explained by risk factors at patient level. MATERIAL AND METHODS:
Variation of the critical percolation threshold in the Achlioptas processes
Giazitzidis, Paraskevas; Argyrakis, Panos
2014-01-01
We investigate variations of the well-known Achlioptas percolation problem, which uses the method of probing sites when building up a lattice system, or probing links when building a network, ultimately resulting in the delay of the appearance of the critical behavior. In the first variation we use two-dimensional lattices, and we apply reverse rules of the Achlioptas model, thus resulting in a speed-up rather than delay of criticality. In a second variation we apply an attractive (and repulsive) rule when building up the lattice, so that newly added sites are either attracted or repelled by the already existing clusters. All these variations result in different values of the percolation threshold, which are herewith reported. Finally, we find that all new models belong to the same universality class as classical percolation.
The nature of solar brightness variations
Shapiro, A. I.; Solanki, S. K.; Krivova, N. A.; Cameron, R. H.; Yeo, K. L.; Schmutz, W. K.
2017-09-01
Determining the sources of solar brightness variations1,2, often referred to as solar noise3, is important because solar noise limits the detection of solar oscillations3, is one of the drivers of the Earth's climate system4,5 and is a prototype of stellar variability6,7—an important limiting factor for the detection of extrasolar planets. Here, we model the magnetic contribution to solar brightness variability using high-cadence8,9 observations from the Solar Dynamics Observatory (SDO) and the Spectral And Total Irradiance REconstruction (SATIRE)10,11 model. The brightness variations caused by the constantly evolving cellular granulation pattern on the solar surface were computed with the Max Planck Institute for Solar System Research (MPS)/University of Chicago Radiative Magnetohydrodynamics (MURaM)12 code. We found that the surface magnetic field and granulation can together precisely explain solar noise (that is, solar variability excluding oscillations) on timescales from minutes to decades, accounting for all timescales that have so far been resolved or covered by irradiance measurements. We demonstrate that no other sources of variability are required to explain the data. Recent measurements of Sun-like stars by the COnvection ROtation and planetary Transits (CoRoT)13 and Kepler14 missions uncovered brightness variations similar to that of the Sun, but with a much wider variety of patterns15. Our finding that solar brightness variations can be replicated in detail with just two well-known sources will greatly simplify future modelling of existing CoRoT and Kepler as well as anticipated Transiting Exoplanet Survey Satellite16 and PLAnetary Transits and Oscillations of stars (PLATO)17 data.
On the minimizers of calculus of variations problems in Hilbert spaces
Gomes, Diogo A.
2014-01-19
The objective of this paper is to discuss existence, uniqueness and regularity issues of minimizers of one dimensional calculus of variations problem in Hilbert spaces. © 2014 Springer-Verlag Berlin Heidelberg.
无
2001-01-01
This paper gives a Fan,s type minimax theorem, a nearst point theorem and two existence theorems of solutions for a kind of generalized quasi-variational inequalities in H-spaces without any linear structure.
Variational Bounds for Creeping Composites
Procházka, Petr
2010-05-01
In the paper time dependent variational bounds are derived based on Extended Hashin-Shtrikman variational principles. Direct calculation leads to explicit formulas to be presented in the text. For various mechanical properties easy coding in Excel, say, can be used and verification of accuracy for numerical procedures is available using the derived formulas.
Robust Understanding of Statistical Variation
Peters, Susan A.
2011-01-01
This paper presents a framework that captures the complexity of reasoning about variation in ways that are indicative of robust understanding and describes reasoning as a blend of design, data-centric, and modeling perspectives. Robust understanding is indicated by integrated reasoning about variation within each perspective and across…
Exploiting Natural Variation in Arabidopsis
Molenaar, J.A.; Keurentjes, J.J.B.
2014-01-01
Natural variation for many traits is present within the species Arabidopsis thaliana . This chapter describes the use of natural variation to elucidate genes underlying the regulation of quantitative traits. It deals with the development and use of mapping populations, the detection and handling of
Exploiting natural variation in Arabidopsis
J.A. Molenaar; J.J.B. Keurentjes
2014-01-01
Natural variation for many traits is present within the species Arabidopsis thaliana. This chapter describes the use of natural variation to elucidate genes underlying the regulation of quantitative traits. It deals with the development and use of mapping populations, the detection and handling of g
Hong, JaeSub; Allen, B.; Grindlay, J.; Barthelmy, S.; Baker, R.; Gehrels, N.; Cook, W.; Kaye, S.; Harrison, F.
2010-03-01
We describe our development of ProtoEXIST2, the advanced CZT imaging detector and wide field telescope prototype for the High Energy Telescope (HET) on the proposed Energetic X-ray Imaging Survey Telescope (EXIST) mission. EXIST is a multi-wavelength Medium class mission which would explore the early Universe using high redshift Gamma-ray Bursts and survey black holes on all scales. ProtoEXIST2 will demonstrate the feasibility of a large scale imaging module (256 cm2) with a close-tiled array of fine pixel (0.6 mm) CZT with a balloon flight test in 2010 or 2011. This second generation close-tiled CZT imager follows ProtoEXIST1, which had a recent successful balloon flight (see Allen et al in this meeting) using the same area CZT detector module (256 cm2) but with larger pixel size (2.5mm). For signal readout and event processing, we use the Direct-Bond (DB) ASIC, developed for the NuSTAR mission to be used in a close-tiled 2 x 2 array of 2x2 cm2 CZT detectors, each with 32x32 pixels. The DB-ASIC is attractive for a large scale implementation of tiled imaging CZT detectors given its low noise and power consumption (70uW/pixel). We are developing readout for the DB-ASIC that incorporates our back-end FPGA readout architecture developed for ProtoEXIST1 in order to accomplish the 256 cm2 detector module area with totally vertical integration (i.e. no auxialliary boards to the sides of the module. This is required to tile large numbers of modules into the very large total area (4.5m^2) proposed for the HET on EXIST. We review the design of the EXIST/HET and its optimum shielding in light of our ProtoEXIST1 balloon flight and our plan for future development of ProtoEXIST3, a final EXIST/HET detector module that would incorporate a still lower power version of the DB ASIC.
Kehr, Flavius; Wentzel, Daniel; Kowatsch, Tobias; Fleisch, Elgar
2015-01-01
As a potential explanation to measured inconsistencies between stated privacy concerns and actual disclosing behavior, denoted as the "privacy paradox", scholars have proposed a systematic distinction between situational privacy considerations and pre-existing, superordinate factors that shape the decisive situation without being directly connected to the situation itself. Deploying an experimental approach, we explored the dynamics of two types of such pre-existing factors, namely (1) pre-ex...
Exploring language variation across Europe
Hovy, Dirk; Johannsen, Anders Trærup
2016-01-01
Language varies not only between countries, but also along regional and sociodemographic lines. This variation is one of the driving factors behind language change. However, investigating language variation is a complex undertaking: the more factors we want to consider, the more data we need...... training in both variational linguistics and computational methods, a combination that is still not common. We take a first step here to alleviate the problem by providing an interface to explore large-scale language variation along several socio-demographic factors without programming knowledge. It makes...... use of large amounts of data and provides statistical analyses, maps, and interactive features that enable scholars to explore language variation in a data-driven way....
Comparing variation across European countries
Thygesen, Lau C; Baixauli-Pérez, Cristobal; Librero-López, Julián
2015-01-01
BACKGROUND: In geographical studies, population distribution is a key issue. An unequal distribution across units of analysis might entail extra-variation and produce misleading conclusions on healthcare performance variations. This article aims at assessing the impact of building more homogeneous...... units of analysis in the estimation of systematic variation in three countries. METHODS: Hospital discharges for six conditions (congestive heart failure, short-term complications of diabetes, hip fracture, knee replacement, prostatectomy in prostate cancer and percutaneous coronary intervention...... of variation such as Extremal Quotient, Interquartile Interval ratio, Systematic Component of Variation and Empirical Bayes statistic. RESULTS: Ward's method reduced the number of areas, allowing a more homogeneous population distribution, yet 20% of the areas in Portugal exhibited less than 100 000...
Fonetisk variation som social praksis
Maegaard, Marie
2010-01-01
VARIATION I KØBENHAVNSK Sproglig variation kan betragtes på mange måder og ud fra mange forskellige perspektiver alt afhængig af erkendelsesinteresse og fagligt ståsted. I denne artikel vil jeg redegøre for et praksisperspektiv på sproglig variation, og jeg vil give eksempler på analyser af...... fonetisk variation blandt københavnske unge set som social praksis. Fonetisk variation i københavnsk er i de fleste kvantitative sociolingvistiske undersøgelser studeret med udgangspunkt i makrosociale kategorier baseret på alder, køn eller socialklasse (eks. Brink & Lund 1975, Jørgensen 1980, Gregersen...
K. N. Murty
2000-01-01
Full Text Available This paper presents a criterion for the existence and uniqueness of solutions to two and multipoint boundary value problems associated with an nth order nonlinear Lyapunov system. A variation of parameters formula is developed and used as a tool to obtain existence and uniqueness. We discuss solution of the second order problem by the ADI method and develop a fixed point method to find the general solution of the nth order Lyapunov system. The results of Barnett (SIAM J. Appl. Anal. 24(1, 1973 are a particular case.
Genetic variation study of 12 X chromosomal STR in central Thailand population.
Vongpaisarnsin, Kornkiat; Boonlert, Achara; Rasmeepaisarn, Kawin; Dangkao, Piyawan
2016-11-01
Genetic data from 12 short tandem repeats (STR) on the X chromosome are currently used in forensics studies to resolve issues related to complex kinship or when data is missing or ambiguous. In this study, we genotyped these 12 X chromosome STR in DNA collected from individuals from central Thailand (n = 391, 282 men and 109 women) and used this information to calculate allele and haplotype frequencies as well as forensic parameters for kinship calculations. Polymorphism information contents of the loci were range from 0.5283-0.9247, and powers of discrimination in females and males were 0.7666-0.9905 and 0.6085-0.9291, respectively. A diallelic pattern was observed at the locus DXS7132. Moreover, a comparison of genetic distance revealed a close relationship within Asian countries. Our results indicate that the X chromosomal short tandem repeat (X-STR) multiplex system provides highly informative genetic data and could be advantageous in forensic studies.
Some Variations on Total Variation-Based Image Smoothing
2009-03-01
influential paper, Rudin, Osher, and Fatemi [23] suggested using the bounded variation seminorm to smooth images. The functional proposed in their work has...unit square I = [0, 1]2, where the bounded variation seminorm is defined as |f |BV(I) := ∫ I |Df(x)| dx := sup {∫ I f ∇ · p ∣∣∣ p : I → R2,(1) p ∈ C1(I...approximation to the ROF functional. In Section 3, we propose a new formulation of an upwind finite-difference approximation to the bounded variation seminorm
Existence of solutions to nonlinear Hammerstein integral equations and applications
Li, Fuyi; Li, Yuhua; Liang, Zhanping
2006-11-01
In this paper, we study the existence and multiplicity of solutions of the operator equation Kfu=u in the real Hilbert space L2(G). Under certain conditions on the linear operator K, we establish the conditions on f which are able to guarantee that the operator equation has at least one solution, a unique solution, and infinitely many solutions, respectively. The monotone operator principle and the critical point theory are employed to discuss this problem, respectively. In argument, quadratic root operator K1/2 and its properties play an important role. As an application, we investigate the existence and multiplicity of solutions to fourth-order boundary value problems for ordinary differential equations with two parameters, and give some new existence results of solutions.
Existing sustainable renovation concepts for single-family houses
Tommerup, Henrik M.; Vanhoutteghem, Lies; Svendsen, Svend
2010-01-01
with individual solutions, traditional warehouses ”do-it-yourself-shops” and some actors marketing single products. To speed up the implementation of sustainable renovation of single-family houses there is a great need for full-service packages. Existing technical renovation concepts, typically focusing......In the Nordic Innovation Centre Project, SuccessFamilies, the main objective is to change the business environment in order to speed up the implementation of sustainable renovation of single-family houses – proposing new service concepts that will combine both the technical solutions, financing...... services as well as other promoting issues to overcome the behavioural, organizational, legal and social barriers that exist in sustainable renovation. A starting point for such a change has been to get an overview of the existing sustainable renovation concepts, i.e. full-service concepts and technical...
Proving Light Quanta Exist in an Undergraduate Laboratory
Neel, M. S.; Thorn, J. J.; Davies, R. E.; Beck, M.
2003-05-01
While well known experiments involving phenomena such as the photoelectric effect and Compton scattering strongly suggest the existence of photons, they do not prove the existence of light quanta. For example, it is possible to explain both of the aforementioned effects using a semiclassical treatment in which the electromagnetic field is not quantized, and is instead treated as a classical wave. To prove the existence of light quanta one must perform an experiment whose results cannot be explained using classical waves. Here we have performed an experiment that cannot be explained with a classical wave theory, and which demonstrates the localization of light quanta. Namely, we prove that a single photon can only go one way when it leaves a beamsplitter. (P. Grangier, G. Roger and A. Aspect, Europhys. Lett. 1, 173 (1986).) The experimental apparatus is appropriate for an undergraduate teaching laboratory.
Existence of bounded positive solutions of a nonlinear differential system
Sabrine Gontara
2012-04-01
Full Text Available In this article, we study the existence and nonexistence of solutions for the system $$displaylines{ frac{1}{A}(Au''=pu^{alpha }v^{s}quad hbox{on }(0,infty , cr frac{1}{B}(Bu''=qu^{r}v^{eta }quad hbox{on }(0,infty , cr Au'(0=0,quad u(infty =a>0, cr Bv'(0=0,quad v(infty =b>0, }$$ where $alpha ,eta geq 1$, $s,rgeq 0$, p,q are two nonnegative functions on $(0,infty $ and A, B satisfy appropriate conditions. Using potential theory tools, we show the existence of a positive continuous solution. This allows us to prove the existence of entire positive radial solutions for some elliptic systems.
Estimation of marginal costs at existing waste treatment facilities
Martinez Sanchez, Veronica; Hulgaard, Tore; Hindsgaul, Claus
2016-01-01
This investigation aims at providing an improved basis for assessing economic consequences of alternative Solid Waste Management (SWM) strategies for existing waste facilities. A bottom-up methodology was developed to determine marginal costs in existing facilities due to changes in the SWM system...... (CHP) and another with only power generation (Power), affected by diversion strategies of five waste fractions (fibres, plastic, metals, organics and glass), named "target fractions". The study assumed three possible responses to waste diversion in the WtE facilities: (i) biomass was added to maintain......, based on the determination of average costs in such waste facilities as function of key facility and waste compositional parameters. The applicability of the method was demonstrated through a case study including two existing Waste-to-Energy (WtE) facilities, one with co-generation of heat and power...
The Faddeev knots as stable solitons:Existence theorems
LIN; Fanghua; YANG; Yisong
2004-01-01
The problem of existence of knot-like solitons as the energy-minimizing configurations in the Faddeev model, topologically characterized by an Hopf invariant, Q, is considered. It is proved that, in the full space situation, there exists an infinite set S of integers so that for any m ∈ S, the Faddeev energy, E, has a minimizer among the class Q = m; in the bounded domain situation, the same existence theorem holds when S is the set of all integers. One of the important technical results is that E and Q satisfy the sublinear inequality E ≤ C|Q|3/4, where C ＞0 is a universal constant, which explains why knotted (clustered soliton) configurations are preferred over widely separated unknotted (multisoliton) configurations when |Q| is sufficiently large.
The existence of a sticking region in free weight squats.
van den Tillaar, Roland; Andersen, Vidar; Saeterbakken, Atle Hole
2014-09-29
The aim of this study was to investigate the existence of the sticking region in two legged free weight squats. Fifteen resistance-training males (age 24 ± 4 years, body mass 82 ± 11 kg, body height 179 ± 6 cm) with 6 ± 3 years of resistance-training experience performed 6-RM in free weight squats. The last repetition was analyzed for the existence of a sticking region. Only in 10 out of 15 participants a sticking region was observed. The observed sticking region was much shorter than in the bench press. Furthermore, rectus femoris decreased the EMG activity in contrast to increased EMG activity in biceps femoris around the sticking and surrounding region. No significant change in EMG activity was found for the lateral and medial vastus muscles. It is suggested that a combination of these muscle activity changes could be one of the causes of the existence of the sticking region in free weight squats.
Existence domains of dust-acoustic solitons and supersolitons
Maharaj, S. K. [South African National Space Agency (SANSA) Space Science, PO Box 32, Hermanus 7200 (South Africa); Bharuthram, R. [University of the Western Cape, Robert Sobukwe Road, Bellville 7535 (South Africa); Singh, S. V.; Lakhina, G. S. [Indian Institute of Geomagnetism, New Panvel, Navi Mumbai 410218 (India)
2013-08-15
Using the Sagdeev potential method, the existence of large amplitude dust-acoustic solitons and supersolitons is investigated in a plasma comprising cold negative dust, adiabatic positive dust, Boltzmann electrons, and non-thermal ions. This model supports the existence of positive potential supersolitons in a certain region in parameter space in addition to regular solitons having negative and positive potentials. The lower Mach number limit for supersolitons coincides with the occurrence of double layers whereas the upper limit is imposed by the constraint that the adiabatic positive dust number density must remain real valued. The upper Mach number limits for negative potential (positive potential) solitons coincide with limiting values of the negative (positive) potential for which the negative (positive) dust number density is real valued. Alternatively, the existence of positive potential solitons can terminate when positive potential double layers occur.
Colorectal cancer screening: a global overview of existing programmes.
Schreuders, Eline H; Ruco, Arlinda; Rabeneck, Linda; Schoen, Robert E; Sung, Joseph J Y; Young, Graeme P; Kuipers, Ernst J
2015-10-01
Colorectal cancer (CRC) ranks third among the most commonly diagnosed cancers worldwide, with wide geographical variation in incidence and mortality across the world. Despite proof that screening can decrease CRC incidence and mortality, CRC screening is only offered to a small proportion of the target population worldwide. Throughout the world there are widespread differences in CRC screening implementation status and strategy. Differences can be attributed to geographical variation in CRC incidence, economic resources, healthcare structure and infrastructure to support screening such as the ability to identify the target population at risk and cancer registry availability. This review highlights issues to consider when implementing a CRC screening programme and gives a worldwide overview of CRC burden and the current status of screening programmes, with focus on international differences.
FMDP reactor alternative summary report. Volume 1 - existing LWR alternative
Greene, S.R.; Bevard, B.B. [and others
1996-10-07
Significant quantities of weapons-usable fissile materials [primarily plutonium and highly enriched uranium (HEU)] are becoming surplus to national defense needs in both the United States and Russia. These stocks of fissile materials pose significant dangers to national and international security. The dangers exist not only in the potential proliferation of nuclear weapons but also in the potential for environmental, safety, and health (ES&H) consequences if surplus fissile materials are not properly managed. This document summarizes the results of analysis concerned with existing light water reactor plutonium disposition alternatives.
Existence and Stability of Gauged Non-Topological Solitons
Lee, Chul H.; Yoon, Seung Un
Classical non-topological soliton configurations are considered in a theory with a local U(1) symmetry. Their existence, stability against dispersion into free particles are studied numerically. As in the case of Friedberg, Lee, and Sirlin with a global U(1) symmetry, also in this case there are two critical charges; Qc for the existence and Qs for the stability of the non-topological soliton configurations. Our numerical results show that the magnitudes of both Qc and Qs increase as the magnitude of the gauge coupling constant e is increased with the other parameters kept at fixed values.
On the existence of localized excitations in nonlinear hamiltonian lattices
Flach, S
1994-01-01
We consider time-periodic nonlinear localized excitations (NLEs) on one-dimensional translationally invariant Hamiltonian lattices with arbitrary finite interaction range and arbitrary finite number of degrees of freedom per unit cell. We analyse a mapping of the Fourier coefficients of the NLE solution. NLEs correspond to homoclinic points in the phase space of this map. Using dimensionality properties of separatrix manifolds of the mapping we show the persistence of NLE solutions under perturbations of the system, provided NLEs exist for the given system. For a class of nonintegrable Fermi-Pasta-Ulam chains we rigorously prove the existence of NLE solutions.
Existing PON Infrastructure Supported Hybrid Fiber-Wireless Sensor Networks
Yu, Xianbin; Zhao, Ying; Deng, Lei;
2012-01-01
We propose a hybrid fiber wireless sensor network based on the existing PON infrastructure. The feasibility of remote sensing and PON convergence is experimentally proven by transmitting direct-sequence spread-spectrum wireless sensing and 2.5Gbps GPON signals.......We propose a hybrid fiber wireless sensor network based on the existing PON infrastructure. The feasibility of remote sensing and PON convergence is experimentally proven by transmitting direct-sequence spread-spectrum wireless sensing and 2.5Gbps GPON signals....
On the Existence of Feller Semigroups with Discontinuous Coefficients
Kazuaki TAIRA
2006-01-01
This paper is devoted to the functional analytic approach to the problem of the existence of Markov processes in probability theory. More precisely, we construct Feller semigroups with Dirichlet conditions for second-order, uniformly elliptic integro-differential operators with discontinuous coefficients. In other words, we prove that there exists a Feller semigroup corresponding to such a diffusion phenomenon that a Markovian particle moves both by jumps and continuously in the state space until it dies at the time when it reaches the boundary.
Existence of homoclinic connections in continuous piecewise linear systems.
Carmona, Victoriano; Fernández-Sánchez, Fernando; García-Medina, Elisabeth; Teruel, Antonio E
2010-03-01
Numerical methods are often used to put in evidence the existence of global connections in differential systems. The principal reason is that the corresponding analytical proofs are usually very complicated. In this work we give an analytical proof of the existence of a pair of homoclinic connections in a continuous piecewise linear system, which can be considered to be a version of the widely studied Michelson system. Although the computations developed in this proof are specific to the system, the techniques can be extended to other piecewise linear systems.
The Existence of Strongly-MDS Convolutional Codes
Hutchinson, Ryan
2008-01-01
It is known that maximum distance separable and maximum distance profile convolutional codes exist over large enough finite fields of any characteristic for all parameters $(n,k,\\delta)$. It has been conjectured that the same is true for convolutional codes that are strongly maximum distance separable. Using methods from linear systems theory, we resolve this conjecture by showing that, over a large enough finite field of any characteristic, codes which are simultaneously maximum distance profile and strongly maximum distance separable exist for all parameters $(n,k,\\delta)$.
Myotoxicity of telbivudine in pre-existing muscle damage
Ay Leyla
2010-11-01
Full Text Available Abstract Objectives It is unknown if telbivudine causes muscle damage only in patients with pre-existing muscle pathology. Case report A 27 yo male of African origin received telbivudine for hepatitis B during 3 months. Three weeks after initiation of the drug he developed myalgia, and tiredness. Creatine-kinase increased from 278 U/l (n, Conclusions Telbivudine appears to cause accelerated muscle toxicity if given to patients who already have muscle damage. Patients under telbivudine should be closely monitored for muscular side effects and those with pre-existing muscle damage should not receive the drug.
Existing and Expected Service Quality of Grameenphone Users in Bangladesh
Azmat Ullah
2015-12-01
Full Text Available The Grameenphone (GP is a market leader in the telecommunication industry in Bangladesh. This study investigates the existing and expected service quality of Grameenphone users in Bangladesh. The Study reveals that there are significant gap between existing and expected perceived service network, 3G, customer care, physical facilities, billing cost, information service, mobile banking and GP offers. The study concludes that customer satisfaction is a dynamic phenomenon. Maintaining desired level of customer satisfaction requires corporate proactive responsiveness in accessing, building & retaining satisfied customers for sustainable competitive advantages in the marketplace.
Existence and uniqueness of positive solutions of semilinear elliptic equations
2007-01-01
This paper is devoted to the study of existence,uniqueness and non-degeneracy of positive solutions of semi-linear elliptic equations.A necessary and sufficient condition for the existence of positive solutions to problems is given.We prove that if the uniqueness and non-degeneracy results are valid for positive solutions of a class of semi-linear elliptic equations,then they are still valid when one perturbs the differential operator a little bit.As consequences,some uniqueness results of positive solutions under the domain perturbation are also obtained.
Existence and uniqueness of positive solutions of semilinear elliptic equations
Qiu-yi DAI; Yu-xia FU; Yong-geng GU
2007-01-01
This paper is devoted to the study of existence, uniqueness and non-degeneracy of positive solutions of semi-linear elliptic equations. A necessary and sufficient condition for the existence of positive solutions to problems is given. We prove that if the uniqueness and non-degeneracy results are valid for positive solutions of a class of semi-linear elliptic equations, then they are still valid when one perturbs the differential operator a little bit. As consequences, some uniqueness results of positive solutions under the domain perturbation are also obtained.
A derivability criterion based on the existence of adjunctions
Rodriguez-Gonzalez, Beatriz
2012-01-01
In this paper we introduce a derivability criterion of functors based on the existence of adjunctions rather than on the existence of resolutions. It constitutes a converse of Quillen-Maltsiniotis derived adjunction theorem. We present two applications of our derivability criterion. On the one hand, we prove that the two notions for homotopy colimits corresponding to Grothendieck derivators and Quillen model categories are equivalent. On the other hand, we deduce that the internal hom for derived Morita theory constructed by B. To\\"en is indeed the right derived functor of the internal hom of dg-categories.
Genome Variation Within Triticale in Comparison to its Wheat and Rye Progenitors
Genome variation in the intergeneric wheat-rye hybrid triticale (X Triticosecale Wittmack) has been a puzzle to scientists and plant breeders since the first triticale was synthesized. The existence of unexplained genetic variation in triticale as compared to the parents has been a hindrance to bre...
Personality matters: individual variation in reactions of naive bird predators to aposematic prey
Exnerová, A.; Hotova Svadova, K.; Fucikova, E.; Drent, P.; Stys, P.
2010-01-01
Variation in reactions to aposematic prey is common among conspecific individuals of bird predators. It may result from different individual experience but it also exists among naive birds. This variation may possibly be explained by the effect of personality—a complex of correlated, heritable
Personality matters: individual variation in reactions of naive bird predators to aposematic prey
Exnerová, A.; Hotova Svadova, K.; Fucikova, E.; Drent, P.; Stys, P.
2010-01-01
Variation in reactions to aposematic prey is common among conspecific individuals of bird predators. It may result from different individual experience but it also exists among naive birds. This variation may possibly be explained by the effect of personality—a complex of correlated, heritable behav
Test Format and the Variation of Gender Achievement Gaps within the United States
Reardon, Sean; Fahle, Erin; Kalogrides, Demetra; Podolsky, Anne; Zarate, Rosalia
2016-01-01
Prior research demonstrates the existence of gender achievement gaps and the variation in the magnitude of these gaps across states. This paper characterizes the extent to which the variation of gender achievement gaps on standardized tests across the United States can be explained by differing state accountability test formats. A comprehensive…
Energy Conservation in Existing Housing Sites. A Comparative Case Analysis in the Netherlands
Hoppe, T.; Bressers, H.; Lulofs, K.
2009-10-15
The housing sector in the Netherlands is responsible for a significant fraction of primary energy use and CO2 emissions. Great energy conservation opportunities are to be found in the existing housing stock, especially in large renovation projects on existing sites. Energy conservation savings of up to 90% are technically feasible. Despite this, there is little empirical evidence available about processes that influence the achievement of energy conservation goals in such locations. Moreover, no systematic, bottom-up research on the matter is available. This paper attempts to answer questions about the factors - size, direction and significance - that explain variation in the degree of energy conservation. Four main propositions were tested, comprising the following variables: actor characteristics, policy instruments, inter organizational collaboration and context. The study used a comparative research design. Data were collected from eleven existing housing sites where renovation projects had been executed, involving 70 personal interviews, a survey, and the collection of project documents. A mixed methods approach was applied for data analysis. The results show that interorganizational, collaborative efforts, policy instruments and the presence of wealthy housing associations have a positive influence on energy conservation outcomes. The mean energy conservation was slightly less than 40%, and outcomes varied between 26.5% and 69.8%. Strikingly, planning does not have a beneficial influence and the actual outcome is lower than predicted. The results are useful for national and local government policy makers, as they clearly argue that ambitious policy goals should be tempered.
Queen Size Variation in the Ponerine Ant Ponera coarctata (Hymenoptera: Formicidae
J. Liebig
1995-01-01
Full Text Available Queens of Ponera coarctata show a pronounced variation in size as measured by ommatidia number and Weber's alitrunk length. Isometric size variation and the normal distribution of size categories indicate that, despite these differences, only one queen morph exists. Queen size varies less within colonies than between colonies, and thus appears to be colony specific. Ovary length apparently varies with queen size. Similar size variations as in queens also occured in males, but not in workers.